id	sid	tid	token	lemma	pos
cord-018834-4ligp4ak	1	1	key	key	JJ
cord-018834-4ligp4ak	1	2	:	:	:
cord-018834-4ligp4ak	1	3	cord-018834	cord-018834	NNS
cord-018834-4ligp4ak	1	4	-	-	HYPH
cord-018834-4ligp4ak	1	5	4ligp4ak	4ligp4ak	CD
cord-018834-4ligp4ak	2	1	authors	author	NNS
cord-018834-4ligp4ak	2	2	:	:	:
cord-018834-4ligp4ak	2	3	Farag	Farag	NNP
cord-018834-4ligp4ak	2	4	,	,	,
cord-018834-4ligp4ak	2	5	Ehab	Ehab	NNP
cord-018834-4ligp4ak	2	6	;	;	:
cord-018834-4ligp4ak	2	7	Ebrahim	Ebrahim	NNP
cord-018834-4ligp4ak	2	8	,	,	,
cord-018834-4ligp4ak	3	1	Zeyd	Zeyd	NNP
cord-018834-4ligp4ak	3	2	Y.	Y.	NNP
cord-018834-4ligp4ak	3	3	title	title	NN
cord-018834-4ligp4ak	3	4	:	:	:
cord-018834-4ligp4ak	4	1	The	the	DT
cord-018834-4ligp4ak	4	2	Perioperative	Perioperative	NNP
cord-018834-4ligp4ak	4	3	Use	Use	NNP
cord-018834-4ligp4ak	4	4	of	of	IN
cord-018834-4ligp4ak	4	5	Albumin	albumin	NN
cord-018834-4ligp4ak	4	6	date	date	NN
cord-018834-4ligp4ak	4	7	:	:	:
cord-018834-4ligp4ak	4	8	2016	2016	CD
cord-018834-4ligp4ak	4	9	-	-	HYPH
cord-018834-4ligp4ak	4	10	06	06	CD
cord-018834-4ligp4ak	4	11	-	-	SYM
cord-018834-4ligp4ak	4	12	23	23	CD
cord-018834-4ligp4ak	4	13	journal	journal	NN
cord-018834-4ligp4ak	4	14	:	:	:
cord-018834-4ligp4ak	5	1	Perioperative	Perioperative	NNP
cord-018834-4ligp4ak	5	2	Fluid	Fluid	NNP
cord-018834-4ligp4ak	5	3	Management	Management	NNP
cord-018834-4ligp4ak	5	4	DOI	doi	NN
cord-018834-4ligp4ak	5	5	:	:	:
cord-018834-4ligp4ak	6	1	10.1007/978	10.1007/978	LS
cord-018834-4ligp4ak	6	2	-	-	SYM
cord-018834-4ligp4ak	6	3	3	3	CD
cord-018834-4ligp4ak	6	4	-	-	HYPH
cord-018834-4ligp4ak	6	5	319	319	CD
cord-018834-4ligp4ak	6	6	-	-	HYPH
cord-018834-4ligp4ak	6	7	39141	39141	CD
cord-018834-4ligp4ak	6	8	-	-	HYPH
cord-018834-4ligp4ak	6	9	0_9	0_9	CD
cord-018834-4ligp4ak	6	10	sha	sha	NNP
cord-018834-4ligp4ak	6	11	:	:	:
cord-018834-4ligp4ak	6	12	b847d808761705ef2550dc3bb6edeffe67da8731	b847d808761705ef2550dc3bb6edeffe67da8731	NNP
cord-018834-4ligp4ak	6	13	doc_id	doc_id	NNP
cord-018834-4ligp4ak	6	14	:	:	:
cord-018834-4ligp4ak	6	15	18834	18834	CD
cord-018834-4ligp4ak	6	16	cord_uid	cord_uid	NNS
cord-018834-4ligp4ak	6	17	:	:	:
cord-018834-4ligp4ak	6	18	4ligp4ak	4ligp4ak	CD
cord-018834-4ligp4ak	7	1	Human	human	JJ
cord-018834-4ligp4ak	7	2	serum	serum	NN
cord-018834-4ligp4ak	7	3	albumin	albumin	NN
cord-018834-4ligp4ak	7	4	(	(	-LRB-
cord-018834-4ligp4ak	7	5	HSA	HSA	NNP
cord-018834-4ligp4ak	7	6	)	)	-RRB-
cord-018834-4ligp4ak	7	7	is	be	VBZ
cord-018834-4ligp4ak	7	8	the	the	DT
cord-018834-4ligp4ak	7	9	predominant	predominant	JJ
cord-018834-4ligp4ak	7	10	product	product	NN
cord-018834-4ligp4ak	7	11	of	of	IN
cord-018834-4ligp4ak	7	12	hepatic	hepatic	JJ
cord-018834-4ligp4ak	7	13	protein	protein	NN
cord-018834-4ligp4ak	7	14	synthesis	synthesis	NN
cord-018834-4ligp4ak	7	15	and	and	CC
cord-018834-4ligp4ak	7	16	one	one	CD
cord-018834-4ligp4ak	7	17	of	of	IN
cord-018834-4ligp4ak	7	18	the	the	DT
cord-018834-4ligp4ak	7	19	more	more	RBR
cord-018834-4ligp4ak	7	20	abundant	abundant	JJ
cord-018834-4ligp4ak	7	21	plasma	plasma	NN
cord-018834-4ligp4ak	7	22	proteins	protein	NNS
cord-018834-4ligp4ak	7	23	.	.	.
cord-018834-4ligp4ak	8	1	HSA	HSA	NNP
cord-018834-4ligp4ak	8	2	is	be	VBZ
cord-018834-4ligp4ak	8	3	a	a	DT
cord-018834-4ligp4ak	8	4	monomeric	monomeric	JJ
cord-018834-4ligp4ak	8	5	multidomain	multidomain	NN
cord-018834-4ligp4ak	8	6	macromolecule	macromolecule	NN
cord-018834-4ligp4ak	8	7	,	,	,
cord-018834-4ligp4ak	8	8	representing	represent	VBG
cord-018834-4ligp4ak	8	9	the	the	DT
cord-018834-4ligp4ak	8	10	main	main	JJ
cord-018834-4ligp4ak	8	11	determinant	determinant	NN
cord-018834-4ligp4ak	8	12	of	of	IN
cord-018834-4ligp4ak	8	13	plasma	plasma	NN
cord-018834-4ligp4ak	8	14	oncotic	oncotic	JJ
cord-018834-4ligp4ak	8	15	pressure	pressure	NN
cord-018834-4ligp4ak	8	16	and	and	CC
cord-018834-4ligp4ak	8	17	the	the	DT
cord-018834-4ligp4ak	8	18	main	main	JJ
cord-018834-4ligp4ak	8	19	modulator	modulator	NN
cord-018834-4ligp4ak	8	20	of	of	IN
cord-018834-4ligp4ak	8	21	fluid	fluid	JJ
cord-018834-4ligp4ak	8	22	distribution	distribution	NN
cord-018834-4ligp4ak	8	23	between	between	IN
cord-018834-4ligp4ak	8	24	body	body	NN
cord-018834-4ligp4ak	8	25	compartments	compartment	NNS
cord-018834-4ligp4ak	8	26	.	.	.
cord-018834-4ligp4ak	9	1	HSA	HSA	NNP
cord-018834-4ligp4ak	9	2	displays	display	VBZ
cord-018834-4ligp4ak	9	3	an	an	DT
cord-018834-4ligp4ak	9	4	essential	essential	JJ
cord-018834-4ligp4ak	9	5	role	role	NN
cord-018834-4ligp4ak	9	6	in	in	IN
cord-018834-4ligp4ak	9	7	maintaining	maintain	VBG
cord-018834-4ligp4ak	9	8	the	the	DT
cord-018834-4ligp4ak	9	9	integrity	integrity	NN
cord-018834-4ligp4ak	9	10	of	of	IN
cord-018834-4ligp4ak	9	11	the	the	DT
cord-018834-4ligp4ak	9	12	vascular	vascular	JJ
cord-018834-4ligp4ak	9	13	barrier	barrier	NN
cord-018834-4ligp4ak	9	14	.	.	.
cord-018834-4ligp4ak	10	1	HSA	HSA	NNP
cord-018834-4ligp4ak	10	2	is	be	VBZ
cord-018834-4ligp4ak	10	3	the	the	DT
cord-018834-4ligp4ak	10	4	most	most	RBS
cord-018834-4ligp4ak	10	5	important	important	JJ
cord-018834-4ligp4ak	10	6	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	10	7	capacity	capacity	NN
cord-018834-4ligp4ak	10	8	of	of	IN
cord-018834-4ligp4ak	10	9	human	human	JJ
cord-018834-4ligp4ak	10	10	plasma	plasma	NN
cord-018834-4ligp4ak	10	11	,	,	,
cord-018834-4ligp4ak	10	12	in	in	IN
cord-018834-4ligp4ak	10	13	addition	addition	NN
cord-018834-4ligp4ak	10	14	to	to	IN
cord-018834-4ligp4ak	10	15	its	-PRON-	PRP$
cord-018834-4ligp4ak	10	16	ability	ability	NN
cord-018834-4ligp4ak	10	17	to	to	TO
cord-018834-4ligp4ak	10	18	protect	protect	VB
cord-018834-4ligp4ak	10	19	the	the	DT
cord-018834-4ligp4ak	10	20	body	body	NN
cord-018834-4ligp4ak	10	21	from	from	IN
cord-018834-4ligp4ak	10	22	the	the	DT
cord-018834-4ligp4ak	10	23	harmful	harmful	JJ
cord-018834-4ligp4ak	10	24	effects	effect	NNS
cord-018834-4ligp4ak	10	25	of	of	IN
cord-018834-4ligp4ak	10	26	heavy	heavy	JJ
cord-018834-4ligp4ak	10	27	metals	metal	NNS
cord-018834-4ligp4ak	10	28	such	such	JJ
cord-018834-4ligp4ak	10	29	as	as	IN
cord-018834-4ligp4ak	10	30	iron	iron	NN
cord-018834-4ligp4ak	10	31	and	and	CC
cord-018834-4ligp4ak	10	32	copper	copper	NN
cord-018834-4ligp4ak	10	33	and	and	CC
cord-018834-4ligp4ak	10	34	reduce	reduce	VB
cord-018834-4ligp4ak	10	35	their	-PRON-	PRP$
cord-018834-4ligp4ak	10	36	ability	ability	NN
cord-018834-4ligp4ak	10	37	to	to	TO
cord-018834-4ligp4ak	10	38	produce	produce	VB
cord-018834-4ligp4ak	10	39	reactive	reactive	JJ
cord-018834-4ligp4ak	10	40	oxygen	oxygen	NN
cord-018834-4ligp4ak	10	41	radicals	radical	NNS
cord-018834-4ligp4ak	10	42	.	.	.
cord-018834-4ligp4ak	11	1	HSA	HSA	NNP
cord-018834-4ligp4ak	11	2	is	be	VBZ
cord-018834-4ligp4ak	11	3	the	the	DT
cord-018834-4ligp4ak	11	4	main	main	JJ
cord-018834-4ligp4ak	11	5	depot	depot	NN
cord-018834-4ligp4ak	11	6	for	for	IN
cord-018834-4ligp4ak	11	7	nitric	nitric	NN
cord-018834-4ligp4ak	11	8	oxide	oxide	NN
cord-018834-4ligp4ak	11	9	(	(	-LRB-
cord-018834-4ligp4ak	11	10	NO	no	DT
cord-018834-4ligp4ak	11	11	)	)	-RRB-
cord-018834-4ligp4ak	11	12	transport	transport	NN
cord-018834-4ligp4ak	11	13	in	in	IN
cord-018834-4ligp4ak	11	14	the	the	DT
cord-018834-4ligp4ak	11	15	blood	blood	NN
cord-018834-4ligp4ak	11	16	.	.	.
cord-018834-4ligp4ak	12	1	HSA	HSA	NNP
cord-018834-4ligp4ak	12	2	represents	represent	VBZ
cord-018834-4ligp4ak	12	3	the	the	DT
cord-018834-4ligp4ak	12	4	main	main	JJ
cord-018834-4ligp4ak	12	5	carrier	carrier	NN
cord-018834-4ligp4ak	12	6	for	for	IN
cord-018834-4ligp4ak	12	7	fatty	fatty	JJ
cord-018834-4ligp4ak	12	8	acids	acid	NNS
cord-018834-4ligp4ak	12	9	,	,	,
cord-018834-4ligp4ak	12	10	affects	affect	VBZ
cord-018834-4ligp4ak	12	11	pharmacokinetics	pharmacokinetic	NNS
cord-018834-4ligp4ak	12	12	of	of	IN
cord-018834-4ligp4ak	12	13	many	many	JJ
cord-018834-4ligp4ak	12	14	drugs	drug	NNS
cord-018834-4ligp4ak	12	15	,	,	,
cord-018834-4ligp4ak	12	16	and	and	CC
cord-018834-4ligp4ak	12	17	provides	provide	VBZ
cord-018834-4ligp4ak	12	18	the	the	DT
cord-018834-4ligp4ak	12	19	metabolic	metabolic	JJ
cord-018834-4ligp4ak	12	20	modification	modification	NN
cord-018834-4ligp4ak	12	21	of	of	IN
cord-018834-4ligp4ak	12	22	some	some	DT
cord-018834-4ligp4ak	12	23	drugs	drug	NNS
cord-018834-4ligp4ak	12	24	and	and	CC
cord-018834-4ligp4ak	12	25	displays	display	VBZ
cord-018834-4ligp4ak	12	26	pseudo	pseudo	JJ
cord-018834-4ligp4ak	12	27	-	-	JJ
cord-018834-4ligp4ak	12	28	enzymatic	enzymatic	JJ
cord-018834-4ligp4ak	12	29	properties	property	NNS
cord-018834-4ligp4ak	12	30	.	.	.
cord-018834-4ligp4ak	13	1	HSA	HSA	NNP
cord-018834-4ligp4ak	13	2	has	have	VBZ
cord-018834-4ligp4ak	13	3	been	be	VBN
cord-018834-4ligp4ak	13	4	widely	widely	RB
cord-018834-4ligp4ak	13	5	used	use	VBN
cord-018834-4ligp4ak	13	6	successfully	successfully	RB
cord-018834-4ligp4ak	13	7	for	for	IN
cord-018834-4ligp4ak	13	8	more	more	JJR
cord-018834-4ligp4ak	13	9	than	than	IN
cord-018834-4ligp4ak	13	10	50	50	CD
cord-018834-4ligp4ak	13	11	years	year	NNS
cord-018834-4ligp4ak	13	12	in	in	IN
cord-018834-4ligp4ak	13	13	many	many	JJ
cord-018834-4ligp4ak	13	14	settings	setting	NNS
cord-018834-4ligp4ak	13	15	of	of	IN
cord-018834-4ligp4ak	13	16	perioperative	perioperative	JJ
cord-018834-4ligp4ak	13	17	medicine	medicine	NN
cord-018834-4ligp4ak	13	18	including	include	VBG
cord-018834-4ligp4ak	13	19	hypovolemia	hypovolemia	NN
cord-018834-4ligp4ak	13	20	,	,	,
cord-018834-4ligp4ak	13	21	shock	shock	NN
cord-018834-4ligp4ak	13	22	,	,	,
cord-018834-4ligp4ak	13	23	burns	burn	NNS
cord-018834-4ligp4ak	13	24	,	,	,
cord-018834-4ligp4ak	13	25	surgical	surgical	JJ
cord-018834-4ligp4ak	13	26	blood	blood	NN
cord-018834-4ligp4ak	13	27	loss	loss	NN
cord-018834-4ligp4ak	13	28	,	,	,
cord-018834-4ligp4ak	13	29	sepsis	sepsis	NN
cord-018834-4ligp4ak	13	30	,	,	,
cord-018834-4ligp4ak	13	31	and	and	CC
cord-018834-4ligp4ak	13	32	acute	acute	JJ
cord-018834-4ligp4ak	13	33	respiratory	respiratory	JJ
cord-018834-4ligp4ak	13	34	distress	distress	NN
cord-018834-4ligp4ak	13	35	syndrome	syndrome	NN
cord-018834-4ligp4ak	13	36	(	(	-LRB-
cord-018834-4ligp4ak	13	37	ARDS	ARDS	NNP
cord-018834-4ligp4ak	13	38	)	)	-RRB-
cord-018834-4ligp4ak	13	39	.	.	.
cord-018834-4ligp4ak	14	1	Recently	recently	RB
cord-018834-4ligp4ak	14	2	,	,	,
cord-018834-4ligp4ak	14	3	the	the	DT
cord-018834-4ligp4ak	14	4	use	use	NN
cord-018834-4ligp4ak	14	5	of	of	IN
cord-018834-4ligp4ak	14	6	HSA	HSA	NNP
cord-018834-4ligp4ak	14	7	has	have	VBZ
cord-018834-4ligp4ak	14	8	shown	show	VBN
cord-018834-4ligp4ak	14	9	a	a	DT
cord-018834-4ligp4ak	14	10	promising	promising	JJ
cord-018834-4ligp4ak	14	11	neuroprotective	neuroprotective	JJ
cord-018834-4ligp4ak	14	12	effect	effect	NN
cord-018834-4ligp4ak	14	13	in	in	IN
cord-018834-4ligp4ak	14	14	patients	patient	NNS
cord-018834-4ligp4ak	14	15	with	with	IN
cord-018834-4ligp4ak	14	16	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	14	17	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	14	18	.	.	.
cord-018834-4ligp4ak	15	1	The	the	DT
cord-018834-4ligp4ak	15	2	most	most	RBS
cord-018834-4ligp4ak	15	3	recent	recent	JJ
cord-018834-4ligp4ak	15	4	evidence	evidence	NN
cord-018834-4ligp4ak	15	5	-	-	HYPH
cord-018834-4ligp4ak	15	6	based	base	VBN
cord-018834-4ligp4ak	15	7	functions	function	NNS
cord-018834-4ligp4ak	15	8	and	and	CC
cord-018834-4ligp4ak	15	9	uses	use	NNS
cord-018834-4ligp4ak	15	10	of	of	IN
cord-018834-4ligp4ak	15	11	HSA	HSA	NNP
cord-018834-4ligp4ak	15	12	in	in	IN
cord-018834-4ligp4ak	15	13	the	the	DT
cord-018834-4ligp4ak	15	14	perioperative	perioperative	JJ
cord-018834-4ligp4ak	15	15	period	period	NN
cord-018834-4ligp4ak	15	16	are	be	VBP
cord-018834-4ligp4ak	15	17	reviewed	review	VBN
cord-018834-4ligp4ak	15	18	in	in	IN
cord-018834-4ligp4ak	15	19	this	this	DT
cord-018834-4ligp4ak	15	20	chapter	chapter	NN
cord-018834-4ligp4ak	15	21	.	.	.
cord-018834-4ligp4ak	16	1	Human	human	JJ
cord-018834-4ligp4ak	16	2	serum	serum	NN
cord-018834-4ligp4ak	16	3	albumin	albumin	NN
cord-018834-4ligp4ak	16	4	(	(	-LRB-
cord-018834-4ligp4ak	16	5	HSA	HSA	NNP
cord-018834-4ligp4ak	16	6	)	)	-RRB-
cord-018834-4ligp4ak	16	7	is	be	VBZ
cord-018834-4ligp4ak	16	8	the	the	DT
cord-018834-4ligp4ak	16	9	most	most	RBS
cord-018834-4ligp4ak	16	10	abundant	abundant	JJ
cord-018834-4ligp4ak	16	11	protein	protein	NN
cord-018834-4ligp4ak	16	12	in	in	IN
cord-018834-4ligp4ak	16	13	the	the	DT
cord-018834-4ligp4ak	16	14	human	human	JJ
cord-018834-4ligp4ak	16	15	plasma	plasma	NN
cord-018834-4ligp4ak	16	16	(	(	-LRB-
cord-018834-4ligp4ak	16	17	40	40	CD
cord-018834-4ligp4ak	16	18	-	-	SYM
cord-018834-4ligp4ak	16	19	50	50	CD
cord-018834-4ligp4ak	16	20	g	g	NN
cord-018834-4ligp4ak	16	21	/	/	SYM
cord-018834-4ligp4ak	16	22	L	L	NNP
cord-018834-4ligp4ak	16	23	)	)	-RRB-
cord-018834-4ligp4ak	16	24	.	.	.
cord-018834-4ligp4ak	17	1	HSA	HSA	NNP
cord-018834-4ligp4ak	17	2	has	have	VBZ
cord-018834-4ligp4ak	17	3	many	many	JJ
cord-018834-4ligp4ak	17	4	functions	function	NNS
cord-018834-4ligp4ak	17	5	;	;	:
cord-018834-4ligp4ak	17	6	it	-PRON-	PRP
cord-018834-4ligp4ak	17	7	is	be	VBZ
cord-018834-4ligp4ak	17	8	the	the	DT
cord-018834-4ligp4ak	17	9	main	main	JJ
cord-018834-4ligp4ak	17	10	regulator	regulator	NN
cord-018834-4ligp4ak	17	11	of	of	IN
cord-018834-4ligp4ak	17	12	the	the	DT
cord-018834-4ligp4ak	17	13	vascular	vascular	JJ
cord-018834-4ligp4ak	17	14	barrier	barrier	NN
cord-018834-4ligp4ak	17	15	,	,	,
cord-018834-4ligp4ak	17	16	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	17	17	in	in	IN
cord-018834-4ligp4ak	17	18	the	the	DT
cord-018834-4ligp4ak	17	19	plasma	plasma	NN
cord-018834-4ligp4ak	17	20	,	,	,
cord-018834-4ligp4ak	17	21	and	and	CC
cord-018834-4ligp4ak	17	22	transporter	transporter	NN
cord-018834-4ligp4ak	17	23	of	of	IN
cord-018834-4ligp4ak	17	24	nitric	nitric	NN
cord-018834-4ligp4ak	17	25	oxide	oxide	NN
cord-018834-4ligp4ak	17	26	(	(	-LRB-
cord-018834-4ligp4ak	17	27	NO	no	UH
cord-018834-4ligp4ak	17	28	)	)	-RRB-
cord-018834-4ligp4ak	17	29	and	and	CC
cord-018834-4ligp4ak	17	30	fatty	fatty	JJ
cord-018834-4ligp4ak	17	31	acids	acid	NNS
cord-018834-4ligp4ak	17	32	and	and	CC
cord-018834-4ligp4ak	17	33	drugs	drug	NNS
cord-018834-4ligp4ak	17	34	.	.	.
cord-018834-4ligp4ak	18	1	HSA	HSA	NNP
cord-018834-4ligp4ak	18	2	infusions	infusion	NNS
cord-018834-4ligp4ak	18	3	have	have	VBP
cord-018834-4ligp4ak	18	4	been	be	VBN
cord-018834-4ligp4ak	18	5	used	use	VBN
cord-018834-4ligp4ak	18	6	successfully	successfully	RB
cord-018834-4ligp4ak	18	7	for	for	IN
cord-018834-4ligp4ak	18	8	more	more	JJR
cord-018834-4ligp4ak	18	9	than	than	IN
cord-018834-4ligp4ak	18	10	50	50	CD
cord-018834-4ligp4ak	18	11	years	year	NNS
cord-018834-4ligp4ak	18	12	since	since	IN
cord-018834-4ligp4ak	18	13	World	World	NNP
cord-018834-4ligp4ak	18	14	War	War	NNP
cord-018834-4ligp4ak	18	15	II	II	NNP
cord-018834-4ligp4ak	18	16	in	in	IN
cord-018834-4ligp4ak	18	17	many	many	JJ
cord-018834-4ligp4ak	18	18	perioperative	perioperative	JJ
cord-018834-4ligp4ak	18	19	settings	setting	NNS
cord-018834-4ligp4ak	18	20	such	such	JJ
cord-018834-4ligp4ak	18	21	as	as	IN
cord-018834-4ligp4ak	18	22	shock	shock	NN
cord-018834-4ligp4ak	18	23	,	,	,
cord-018834-4ligp4ak	18	24	volume	volume	NN
cord-018834-4ligp4ak	18	25	expansion	expansion	NN
cord-018834-4ligp4ak	18	26	,	,	,
cord-018834-4ligp4ak	18	27	burns	burn	NNS
cord-018834-4ligp4ak	18	28	,	,	,
cord-018834-4ligp4ak	18	29	cardiopulmonary	cardiopulmonary	JJ
cord-018834-4ligp4ak	18	30	bypass	bypass	NN
cord-018834-4ligp4ak	18	31	,	,	,
cord-018834-4ligp4ak	18	32	acute	acute	JJ
cord-018834-4ligp4ak	18	33	liver	liver	NN
cord-018834-4ligp4ak	18	34	failure	failure	NN
cord-018834-4ligp4ak	18	35	,	,	,
cord-018834-4ligp4ak	18	36	sepsis	sepsis	NN
cord-018834-4ligp4ak	18	37	,	,	,
cord-018834-4ligp4ak	18	38	and	and	CC
cord-018834-4ligp4ak	18	39	many	many	JJ
cord-018834-4ligp4ak	18	40	more	more	JJR
cord-018834-4ligp4ak	18	41	.	.	.
cord-018834-4ligp4ak	19	1	Recently	recently	RB
cord-018834-4ligp4ak	19	2	,	,	,
cord-018834-4ligp4ak	19	3	its	-PRON-	PRP$
cord-018834-4ligp4ak	19	4	use	use	NN
cord-018834-4ligp4ak	19	5	has	have	VBZ
cord-018834-4ligp4ak	19	6	been	be	VBN
cord-018834-4ligp4ak	19	7	questioned	question	VBN
cord-018834-4ligp4ak	19	8	following	follow	VBG
cord-018834-4ligp4ak	19	9	a	a	DT
cord-018834-4ligp4ak	19	10	widely	widely	RB
cord-018834-4ligp4ak	19	11	publicized	publicize	VBN
cord-018834-4ligp4ak	19	12	meta	meta	NN
cord-018834-4ligp4ak	19	13	-	-	HYPH
cord-018834-4ligp4ak	19	14	analysis	analysis	NN
cord-018834-4ligp4ak	19	15	in	in	IN
cord-018834-4ligp4ak	19	16	1998	1998	CD
cord-018834-4ligp4ak	19	17	that	that	WDT
cord-018834-4ligp4ak	19	18	reported	report	VBD
cord-018834-4ligp4ak	19	19	increased	increase	VBN
cord-018834-4ligp4ak	19	20	mortality	mortality	NN
cord-018834-4ligp4ak	19	21	in	in	IN
cord-018834-4ligp4ak	19	22	patients	patient	NNS
cord-018834-4ligp4ak	19	23	who	who	WP
cord-018834-4ligp4ak	19	24	received	receive	VBD
cord-018834-4ligp4ak	19	25	albumin	albumin	NN
cord-018834-4ligp4ak	19	26	solutions	solution	NNS
cord-018834-4ligp4ak	19	27	;	;	:
cord-018834-4ligp4ak	19	28	the	the	DT
cord-018834-4ligp4ak	19	29	role	role	NN
cord-018834-4ligp4ak	19	30	of	of	IN
cord-018834-4ligp4ak	19	31	albumin	albumin	NN
cord-018834-4ligp4ak	19	32	administration	administration	NN
cord-018834-4ligp4ak	19	33	in	in	IN
cord-018834-4ligp4ak	19	34	critically	critically	RB
cord-018834-4ligp4ak	19	35	ill	ill	JJ
cord-018834-4ligp4ak	19	36	patients	patient	NNS
cord-018834-4ligp4ak	19	37	became	become	VBD
cord-018834-4ligp4ak	19	38	highly	highly	RB
cord-018834-4ligp4ak	19	39	controversial	controversial	JJ
cord-018834-4ligp4ak	19	40	.	.	.
cord-018834-4ligp4ak	20	1	However	however	RB
cord-018834-4ligp4ak	20	2	,	,	,
cord-018834-4ligp4ak	20	3	the	the	DT
cord-018834-4ligp4ak	20	4	results	result	NNS
cord-018834-4ligp4ak	20	5	of	of	IN
cord-018834-4ligp4ak	20	6	this	this	DT
cord-018834-4ligp4ak	20	7	meta	meta	JJ
cord-018834-4ligp4ak	20	8	-	-	HYPH
cord-018834-4ligp4ak	20	9	analysis	analysis	NN
cord-018834-4ligp4ak	20	10	have	have	VBP
cord-018834-4ligp4ak	20	11	been	be	VBN
cord-018834-4ligp4ak	20	12	challenged	challenge	VBN
cord-018834-4ligp4ak	20	13	by	by	IN
cord-018834-4ligp4ak	20	14	several	several	JJ
cord-018834-4ligp4ak	20	15	metaanalyses	metaanalyse	NNS
cord-018834-4ligp4ak	20	16	,	,	,
cord-018834-4ligp4ak	20	17	randomized	randomize	VBN
cord-018834-4ligp4ak	20	18	controlled	control	VBN
cord-018834-4ligp4ak	20	19	trials	trial	NNS
cord-018834-4ligp4ak	20	20	that	that	WDT
cord-018834-4ligp4ak	20	21	not	not	RB
cord-018834-4ligp4ak	20	22	only	only	RB
cord-018834-4ligp4ak	20	23	proved	prove	VBD
cord-018834-4ligp4ak	20	24	the	the	DT
cord-018834-4ligp4ak	20	25	safety	safety	NN
cord-018834-4ligp4ak	20	26	of	of	IN
cord-018834-4ligp4ak	20	27	HSA	HSA	NNP
cord-018834-4ligp4ak	20	28	but	but	CC
cord-018834-4ligp4ak	20	29	its	-PRON-	PRP$
cord-018834-4ligp4ak	20	30	benefi	benefi	NNP
cord-018834-4ligp4ak	20	31	t	t	NN
cord-018834-4ligp4ak	20	32	especially	especially	RB
cord-018834-4ligp4ak	20	33	in	in	IN
cord-018834-4ligp4ak	20	34	patients	patient	NNS
cord-018834-4ligp4ak	20	35	with	with	IN
cord-018834-4ligp4ak	20	36	sepsis	sepsis	NN
cord-018834-4ligp4ak	20	37	,	,	,
cord-018834-4ligp4ak	20	38	liver	liver	NN
cord-018834-4ligp4ak	20	39	failure	failure	NN
cord-018834-4ligp4ak	20	40	,	,	,
cord-018834-4ligp4ak	20	41	hypoalbuminemia	hypoalbuminemia	NN
cord-018834-4ligp4ak	20	42	,	,	,
cord-018834-4ligp4ak	20	43	and	and	CC
cord-018834-4ligp4ak	20	44	burns	burn	NNS
cord-018834-4ligp4ak	20	45	[	[	-LRB-
cord-018834-4ligp4ak	20	46	1	1	CD
cord-018834-4ligp4ak	20	47	-4	-4	CD
cord-018834-4ligp4ak	20	48	]	]	-RRB-
cord-018834-4ligp4ak	20	49	.	.	.
cord-018834-4ligp4ak	21	1	The	the	DT
cord-018834-4ligp4ak	21	2	most	most	RBS
cord-018834-4ligp4ak	21	3	recent	recent	JJ
cord-018834-4ligp4ak	21	4	evidence	evidence	NN
cord-018834-4ligp4ak	21	5	-	-	HYPH
cord-018834-4ligp4ak	21	6	based	base	VBN
cord-018834-4ligp4ak	21	7	functions	function	NNS
cord-018834-4ligp4ak	21	8	and	and	CC
cord-018834-4ligp4ak	21	9	uses	use	NNS
cord-018834-4ligp4ak	21	10	of	of	IN
cord-018834-4ligp4ak	21	11	HSA	HSA	NNP
cord-018834-4ligp4ak	21	12	in	in	IN
cord-018834-4ligp4ak	21	13	the	the	DT
cord-018834-4ligp4ak	21	14	perioperative	perioperative	JJ
cord-018834-4ligp4ak	21	15	settings	setting	NNS
cord-018834-4ligp4ak	21	16	are	be	VBP
cord-018834-4ligp4ak	21	17	reviewed	review	VBN
cord-018834-4ligp4ak	21	18	in	in	IN
cord-018834-4ligp4ak	21	19	this	this	DT
cord-018834-4ligp4ak	21	20	chapter	chapter	NN
cord-018834-4ligp4ak	21	21	.	.	.
cord-018834-4ligp4ak	22	1	Human	human	JJ
cord-018834-4ligp4ak	22	2	serum	serum	NN
cord-018834-4ligp4ak	22	3	albumin	albumin	NN
cord-018834-4ligp4ak	22	4	(	(	-LRB-
cord-018834-4ligp4ak	22	5	HSA	HSA	NNP
cord-018834-4ligp4ak	22	6	)	)	-RRB-
cord-018834-4ligp4ak	22	7	is	be	VBZ
cord-018834-4ligp4ak	22	8	a	a	DT
cord-018834-4ligp4ak	22	9	non	non	JJ
cord-018834-4ligp4ak	22	10	-	-	JJ
cord-018834-4ligp4ak	22	11	glycosylated	glycosylated	JJ
cord-018834-4ligp4ak	22	12	,	,	,
cord-018834-4ligp4ak	22	13	negatively	negatively	RB
cord-018834-4ligp4ak	22	14	charged	charge	VBN
cord-018834-4ligp4ak	22	15	plasma	plasma	NN
cord-018834-4ligp4ak	22	16	protein	protein	NN
cord-018834-4ligp4ak	22	17	.	.	.
cord-018834-4ligp4ak	23	1	HSA	HSA	NNP
cord-018834-4ligp4ak	23	2	is	be	VBZ
cord-018834-4ligp4ak	23	3	a	a	DT
cord-018834-4ligp4ak	23	4	single	single	JJ
cord-018834-4ligp4ak	23	5	polypeptide	polypeptide	NN
cord-018834-4ligp4ak	23	6	chain	chain	NN
cord-018834-4ligp4ak	23	7	of	of	IN
cord-018834-4ligp4ak	23	8	585	585	CD
cord-018834-4ligp4ak	23	9	amino	amino	JJ
cord-018834-4ligp4ak	23	10	acids	acid	NNS
cord-018834-4ligp4ak	23	11	and	and	CC
cord-018834-4ligp4ak	23	12	has	have	VBZ
cord-018834-4ligp4ak	23	13	a	a	DT
cord-018834-4ligp4ak	23	14	molecular	molecular	JJ
cord-018834-4ligp4ak	23	15	mass	mass	NN
cord-018834-4ligp4ak	23	16	of	of	IN
cord-018834-4ligp4ak	23	17	66.5	66.5	CD
cord-018834-4ligp4ak	23	18	KDa	KDa	NNS
cord-018834-4ligp4ak	23	19	.	.	.
cord-018834-4ligp4ak	24	1	HSA	HSA	NNP
cord-018834-4ligp4ak	24	2	consists	consist	VBZ
cord-018834-4ligp4ak	24	3	of	of	IN
cord-018834-4ligp4ak	24	4	α(alpha)-helix	α(alpha)-helix	NNP
cord-018834-4ligp4ak	24	5	but	but	CC
cord-018834-4ligp4ak	24	6	no	no	DT
cord-018834-4ligp4ak	24	7	β(beta)-sheet	β(beta)-sheet	NNP
cord-018834-4ligp4ak	24	8	,	,	,
cord-018834-4ligp4ak	24	9	and	and	CC
cord-018834-4ligp4ak	24	10	it	-PRON-	PRP
cord-018834-4ligp4ak	24	11	consists	consist	VBZ
cord-018834-4ligp4ak	24	12	of	of	IN
cord-018834-4ligp4ak	24	13	three	three	CD
cord-018834-4ligp4ak	24	14	homologous	homologous	JJ
cord-018834-4ligp4ak	24	15	domains	domain	NNS
cord-018834-4ligp4ak	24	16	(	(	-LRB-
cord-018834-4ligp4ak	24	17	I	I	NNP
cord-018834-4ligp4ak	24	18	-	-	HYPH
cord-018834-4ligp4ak	24	19	III	III	NNP
cord-018834-4ligp4ak	24	20	)	)	-RRB-
cord-018834-4ligp4ak	24	21	that	that	WDT
cord-018834-4ligp4ak	24	22	assemble	assemble	VBP
cord-018834-4ligp4ak	24	23	to	to	TO
cord-018834-4ligp4ak	24	24	form	form	VB
cord-018834-4ligp4ak	24	25	a	a	DT
cord-018834-4ligp4ak	24	26	heartshaped	heartshaped	NN
cord-018834-4ligp4ak	24	27	molecule	molecule	NN
cord-018834-4ligp4ak	24	28	.	.	.
cord-018834-4ligp4ak	25	1	Each	each	DT
cord-018834-4ligp4ak	25	2	domain	domain	NN
cord-018834-4ligp4ak	25	3	is	be	VBZ
cord-018834-4ligp4ak	25	4	composed	compose	VBN
cord-018834-4ligp4ak	25	5	of	of	IN
cord-018834-4ligp4ak	25	6	two	two	CD
cord-018834-4ligp4ak	25	7	subdomains	subdomain	NNS
cord-018834-4ligp4ak	25	8	(	(	-LRB-
cord-018834-4ligp4ak	25	9	A	A	NNP
cord-018834-4ligp4ak	25	10	&	&	CC
cord-018834-4ligp4ak	25	11	B	B	NNP
cord-018834-4ligp4ak	25	12	)	)	-RRB-
cord-018834-4ligp4ak	25	13	with	with	IN
cord-018834-4ligp4ak	25	14	distinct	distinct	JJ
cord-018834-4ligp4ak	25	15	helical	helical	JJ
cord-018834-4ligp4ak	25	16	folding	folding	NN
cord-018834-4ligp4ak	25	17	patterns	pattern	NNS
cord-018834-4ligp4ak	25	18	connected	connect	VBN
cord-018834-4ligp4ak	25	19	by	by	IN
cord-018834-4ligp4ak	25	20	fl	fl	JJ
cord-018834-4ligp4ak	25	21	exible	exible	JJ
cord-018834-4ligp4ak	25	22	loops	loop	NNS
cord-018834-4ligp4ak	25	23	.	.	.
cord-018834-4ligp4ak	26	1	The	the	DT
cord-018834-4ligp4ak	26	2	center	center	NN
cord-018834-4ligp4ak	26	3	of	of	IN
cord-018834-4ligp4ak	26	4	the	the	DT
cord-018834-4ligp4ak	26	5	molecule	molecule	NN
cord-018834-4ligp4ak	26	6	is	be	VBZ
cord-018834-4ligp4ak	26	7	made	make	VBN
cord-018834-4ligp4ak	26	8	up	up	RP
cord-018834-4ligp4ak	26	9	of	of	IN
cord-018834-4ligp4ak	26	10	hydrophobic	hydrophobic	JJ
cord-018834-4ligp4ak	26	11	radicals	radical	NNS
cord-018834-4ligp4ak	26	12	,	,	,
cord-018834-4ligp4ak	26	13	which	which	WDT
cord-018834-4ligp4ak	26	14	are	be	VBP
cord-018834-4ligp4ak	26	15	binding	bind	VBG
cord-018834-4ligp4ak	26	16	sites	site	NNS
cord-018834-4ligp4ak	26	17	for	for	IN
cord-018834-4ligp4ak	26	18	many	many	JJ
cord-018834-4ligp4ak	26	19	ligands	ligand	NNS
cord-018834-4ligp4ak	26	20	,	,	,
cord-018834-4ligp4ak	26	21	while	while	IN
cord-018834-4ligp4ak	26	22	the	the	DT
cord-018834-4ligp4ak	26	23	outer	outer	JJ
cord-018834-4ligp4ak	26	24	part	part	NN
cord-018834-4ligp4ak	26	25	of	of	IN
cord-018834-4ligp4ak	26	26	the	the	DT
cord-018834-4ligp4ak	26	27	molecule	molecule	NN
cord-018834-4ligp4ak	26	28	is	be	VBZ
cord-018834-4ligp4ak	26	29	composed	compose	VBN
cord-018834-4ligp4ak	26	30	of	of	IN
cord-018834-4ligp4ak	26	31	hydrophilic	hydrophilic	JJ
cord-018834-4ligp4ak	26	32	ligands	ligand	NNS
cord-018834-4ligp4ak	26	33	(	(	-LRB-
cord-018834-4ligp4ak	26	34	Fig	Fig	NNP
cord-018834-4ligp4ak	26	35	.	.	.
cord-018834-4ligp4ak	26	36	9	9	CD
cord-018834-4ligp4ak	26	37	.1	.1	CD
cord-018834-4ligp4ak	26	38	)	)	-RRB-
cord-018834-4ligp4ak	27	1	[	[	-LRB-
cord-018834-4ligp4ak	27	2	5	5	CD
cord-018834-4ligp4ak	27	3	]	]	-RRB-
cord-018834-4ligp4ak	27	4	.	.	.
cord-018834-4ligp4ak	28	1	HSA	HSA	NNP
cord-018834-4ligp4ak	28	2	is	be	VBZ
cord-018834-4ligp4ak	28	3	a	a	DT
cord-018834-4ligp4ak	28	4	member	member	NN
cord-018834-4ligp4ak	28	5	of	of	IN
cord-018834-4ligp4ak	28	6	the	the	DT
cord-018834-4ligp4ak	28	7	albumin	albumin	NN
cord-018834-4ligp4ak	28	8	superfamily	superfamily	NN
cord-018834-4ligp4ak	28	9	,	,	,
cord-018834-4ligp4ak	28	10	which	which	WDT
cord-018834-4ligp4ak	28	11	also	also	RB
cord-018834-4ligp4ak	28	12	includes	include	VBZ
cord-018834-4ligp4ak	28	13	α(alpha)fetoprotein	α(alpha)fetoprotein	NNP
cord-018834-4ligp4ak	28	14	,	,	,
cord-018834-4ligp4ak	28	15	vitamin	vitamin	NN
cord-018834-4ligp4ak	28	16	D	d	NN
cord-018834-4ligp4ak	28	17	-	-	HYPH
cord-018834-4ligp4ak	28	18	binding	bind	VBG
cord-018834-4ligp4ak	28	19	protein	protein	NN
cord-018834-4ligp4ak	28	20	,	,	,
cord-018834-4ligp4ak	28	21	and	and	CC
cord-018834-4ligp4ak	28	22	afamin	afamin	NNP
cord-018834-4ligp4ak	28	23	(	(	-LRB-
cord-018834-4ligp4ak	28	24	α[alpha]albumin	α[alpha]albumin	NN
cord-018834-4ligp4ak	28	25	)	)	-RRB-
cord-018834-4ligp4ak	28	26	.	.	.
cord-018834-4ligp4ak	29	1	HSA	HSA	NNP
cord-018834-4ligp4ak	29	2	synthesis	synthesis	NN
cord-018834-4ligp4ak	29	3	is	be	VBZ
cord-018834-4ligp4ak	29	4	governed	govern	VBN
cord-018834-4ligp4ak	29	5	by	by	IN
cord-018834-4ligp4ak	29	6	a	a	DT
cord-018834-4ligp4ak	29	7	single	single	JJ
cord-018834-4ligp4ak	29	8	copy	copy	NN
cord-018834-4ligp4ak	29	9	gene	gene	NN
cord-018834-4ligp4ak	29	10	lying	lie	VBG
cord-018834-4ligp4ak	29	11	on	on	IN
cord-018834-4ligp4ak	29	12	the	the	DT
cord-018834-4ligp4ak	29	13	long	long	JJ
cord-018834-4ligp4ak	29	14	arm	arm	NN
cord-018834-4ligp4ak	29	15	of	of	IN
cord-018834-4ligp4ak	29	16	chromosome	chromosome	NN
cord-018834-4ligp4ak	29	17	4	4	CD
cord-018834-4ligp4ak	29	18	,	,	,
cord-018834-4ligp4ak	29	19	near	near	IN
cord-018834-4ligp4ak	29	20	the	the	DT
cord-018834-4ligp4ak	29	21	centromere	centromere	NN
cord-018834-4ligp4ak	29	22	for	for	IN
cord-018834-4ligp4ak	29	23	the	the	DT
cord-018834-4ligp4ak	29	24	long	long	JJ
cord-018834-4ligp4ak	29	25	arm	arm	NN
cord-018834-4ligp4ak	29	26	,	,	,
cord-018834-4ligp4ak	29	27	at	at	IN
cord-018834-4ligp4ak	29	28	position	position	NN
cord-018834-4ligp4ak	29	29	4q11	4q11	CD
cord-018834-4ligp4ak	29	30	-	-	SYM
cord-018834-4ligp4ak	29	31	13	13	CD
cord-018834-4ligp4ak	29	32	.	.	.
cord-018834-4ligp4ak	30	1	The	the	DT
cord-018834-4ligp4ak	30	2	mRNA	mrna	NN
cord-018834-4ligp4ak	30	3	for	for	IN
cord-018834-4ligp4ak	30	4	HSA	HSA	NNP
cord-018834-4ligp4ak	30	5	encodes	encode	VBZ
cord-018834-4ligp4ak	30	6	a	a	DT
cord-018834-4ligp4ak	30	7	precursor	precursor	NN
cord-018834-4ligp4ak	30	8	protein	protein	NN
cord-018834-4ligp4ak	30	9	(	(	-LRB-
cord-018834-4ligp4ak	30	10	preproalbumin	preproalbumin	NNP
cord-018834-4ligp4ak	30	11	)	)	-RRB-
cord-018834-4ligp4ak	30	12	of	of	IN
cord-018834-4ligp4ak	30	13	609	609	CD
cord-018834-4ligp4ak	30	14	amino	amino	NN
cord-018834-4ligp4ak	30	15	acid	acid	NN
cord-018834-4ligp4ak	30	16	residues	residue	NNS
cord-018834-4ligp4ak	30	17	.	.	.
cord-018834-4ligp4ak	31	1	Cleavage	cleavage	NN
cord-018834-4ligp4ak	31	2	of	of	IN
cord-018834-4ligp4ak	31	3	the	the	DT
cord-018834-4ligp4ak	31	4	single	single	JJ
cord-018834-4ligp4ak	31	5	peptide	peptide	NN
cord-018834-4ligp4ak	31	6	of	of	IN
cord-018834-4ligp4ak	31	7	18	18	CD
cord-018834-4ligp4ak	31	8	residues	residue	NNS
cord-018834-4ligp4ak	31	9	and	and	CC
cord-018834-4ligp4ak	31	10	the	the	DT
cord-018834-4ligp4ak	31	11	propeptide	propeptide	NN
cord-018834-4ligp4ak	31	12	(	(	-LRB-
cord-018834-4ligp4ak	31	13	proalbumin	proalbumin	NNP
cord-018834-4ligp4ak	31	14	)	)	-RRB-
cord-018834-4ligp4ak	31	15	of	of	IN
cord-018834-4ligp4ak	31	16	six	six	CD
cord-018834-4ligp4ak	31	17	residues	residue	NNS
cord-018834-4ligp4ak	31	18	yields	yield	VBZ
cord-018834-4ligp4ak	31	19	the	the	DT
cord-018834-4ligp4ak	31	20	mature	mature	JJ
cord-018834-4ligp4ak	31	21	protein	protein	NN
cord-018834-4ligp4ak	31	22	of	of	IN
cord-018834-4ligp4ak	31	23	585	585	CD
cord-018834-4ligp4ak	31	24	residues	residue	NNS
cord-018834-4ligp4ak	31	25	[	[	-LRB-
cord-018834-4ligp4ak	31	26	6	6	CD
cord-018834-4ligp4ak	31	27	]	]	-RRB-
cord-018834-4ligp4ak	31	28	.	.	.
cord-018834-4ligp4ak	32	1	HSA	HSA	NNP
cord-018834-4ligp4ak	32	2	plays	play	VBZ
cord-018834-4ligp4ak	32	3	an	an	DT
cord-018834-4ligp4ak	32	4	integral	integral	JJ
cord-018834-4ligp4ak	32	5	role	role	NN
cord-018834-4ligp4ak	32	6	in	in	IN
cord-018834-4ligp4ak	32	7	maintaining	maintain	VBG
cord-018834-4ligp4ak	32	8	the	the	DT
cord-018834-4ligp4ak	32	9	integrity	integrity	NN
cord-018834-4ligp4ak	32	10	of	of	IN
cord-018834-4ligp4ak	32	11	the	the	DT
cord-018834-4ligp4ak	32	12	vascular	vascular	JJ
cord-018834-4ligp4ak	32	13	barrier	barrier	NN
cord-018834-4ligp4ak	32	14	.	.	.
cord-018834-4ligp4ak	33	1	HSA	HSA	NNP
cord-018834-4ligp4ak	33	2	enhances	enhance	VBZ
cord-018834-4ligp4ak	33	3	the	the	DT
cord-018834-4ligp4ak	33	4	integrity	integrity	NN
cord-018834-4ligp4ak	33	5	by	by	IN
cord-018834-4ligp4ak	33	6	electrostatic	electrostatic	JJ
cord-018834-4ligp4ak	33	7	binding	binding	NN
cord-018834-4ligp4ak	33	8	to	to	IN
cord-018834-4ligp4ak	33	9	the	the	DT
cord-018834-4ligp4ak	33	10	negatively	negatively	RB
cord-018834-4ligp4ak	33	11	charged	charge	VBN
cord-018834-4ligp4ak	33	12	heparin	heparin	NN
cord-018834-4ligp4ak	33	13	sulfate	sulfate	NN
cord-018834-4ligp4ak	33	14	side	side	NN
cord-018834-4ligp4ak	33	15	chains	chain	NNS
cord-018834-4ligp4ak	33	16	of	of	IN
cord-018834-4ligp4ak	33	17	core	core	NN
cord-018834-4ligp4ak	33	18	glycoproteins	glycoprotein	NNS
cord-018834-4ligp4ak	33	19	such	such	JJ
cord-018834-4ligp4ak	33	20	as	as	IN
cord-018834-4ligp4ak	33	21	syndecan-1	syndecan-1	NNP
cord-018834-4ligp4ak	33	22	and	and	CC
cord-018834-4ligp4ak	33	23	glypican-1	glypican-1	NNP
cord-018834-4ligp4ak	33	24	of	of	IN
cord-018834-4ligp4ak	33	25	the	the	DT
cord-018834-4ligp4ak	33	26	endothelial	endothelial	JJ
cord-018834-4ligp4ak	33	27	glycocalyx	glycocalyx	NN
cord-018834-4ligp4ak	33	28	via	via	IN
cord-018834-4ligp4ak	33	29	its	-PRON-	PRP$
cord-018834-4ligp4ak	33	30	positively	positively	RB
cord-018834-4ligp4ak	33	31	charged	charge	VBN
cord-018834-4ligp4ak	33	32	arginine	arginine	NN
cord-018834-4ligp4ak	33	33	residues	residue	NNS
cord-018834-4ligp4ak	33	34	and	and	CC
cord-018834-4ligp4ak	33	35	enhances	enhance	VBZ
cord-018834-4ligp4ak	33	36	the	the	DT
cord-018834-4ligp4ak	33	37	availability	availability	NN
cord-018834-4ligp4ak	33	38	of	of	IN
cord-018834-4ligp4ak	33	39	sphingosine-1-phosphate	sphingosine-1-phosphate	NNP
cord-018834-4ligp4ak	33	40	(	(	-LRB-
cord-018834-4ligp4ak	33	41	S1P	s1p	NN
cord-018834-4ligp4ak	33	42	)	)	-RRB-
cord-018834-4ligp4ak	33	43	produced	produce	VBN
cord-018834-4ligp4ak	33	44	by	by	IN
cord-018834-4ligp4ak	33	45	red	red	JJ
cord-018834-4ligp4ak	33	46	blood	blood	NN
cord-018834-4ligp4ak	33	47	cells	cell	NNS
cord-018834-4ligp4ak	33	48	(	(	-LRB-
cord-018834-4ligp4ak	33	49	RBCs	rbc	NNS
cord-018834-4ligp4ak	33	50	)	)	-RRB-
cord-018834-4ligp4ak	33	51	.	.	.
cord-018834-4ligp4ak	34	1	Extracellular	Extracellular	NNP
cord-018834-4ligp4ak	34	2	sphingosine	sphingosine	NN
cord-018834-4ligp4ak	34	3	is	be	VBZ
cord-018834-4ligp4ak	34	4	taken	take	VBN
cord-018834-4ligp4ak	34	5	up	up	RP
cord-018834-4ligp4ak	34	6	and	and	CC
cord-018834-4ligp4ak	34	7	phosphorylated	phosphorylate	VBN
cord-018834-4ligp4ak	34	8	by	by	IN
cord-018834-4ligp4ak	34	9	RBCs	rbc	NNS
cord-018834-4ligp4ak	34	10	sphingosine	sphingosine	NNP
cord-018834-4ligp4ak	34	11	kinases	kinase	NNS
cord-018834-4ligp4ak	34	12	(	(	-LRB-
cord-018834-4ligp4ak	34	13	SK	SK	NNP
cord-018834-4ligp4ak	34	14	)	)	-RRB-
cord-018834-4ligp4ak	34	15	into	into	IN
cord-018834-4ligp4ak	34	16	S1P	s1p	NN
cord-018834-4ligp4ak	34	17	that	that	WDT
cord-018834-4ligp4ak	34	18	is	be	VBZ
cord-018834-4ligp4ak	34	19	stored	store	VBN
cord-018834-4ligp4ak	34	20	in	in	IN
cord-018834-4ligp4ak	34	21	the	the	DT
cord-018834-4ligp4ak	34	22	cell	cell	NN
cord-018834-4ligp4ak	34	23	membrane	membrane	NN
cord-018834-4ligp4ak	34	24	of	of	IN
cord-018834-4ligp4ak	34	25	RBC	RBC	NNP
cord-018834-4ligp4ak	34	26	.	.	.
cord-018834-4ligp4ak	35	1	S1P	S1P	NNP
cord-018834-4ligp4ak	35	2	is	be	VBZ
cord-018834-4ligp4ak	35	3	extracted	extract	VBN
cord-018834-4ligp4ak	35	4	from	from	IN
cord-018834-4ligp4ak	35	5	the	the	DT
cord-018834-4ligp4ak	35	6	RBC	RBC	NNP
cord-018834-4ligp4ak	35	7	membrane	membrane	NN
cord-018834-4ligp4ak	35	8	by	by	IN
cord-018834-4ligp4ak	35	9	Apo	Apo	NNP
cord-018834-4ligp4ak	35	10	lipoprotein	lipoprotein	NN
cord-018834-4ligp4ak	35	11	M	M	NNP
cord-018834-4ligp4ak	35	12	(	(	-LRB-
cord-018834-4ligp4ak	35	13	ApoM	ApoM	NNP
cord-018834-4ligp4ak	35	14	)	)	-RRB-
cord-018834-4ligp4ak	35	15	of	of	IN
cord-018834-4ligp4ak	35	16	high	high	JJ
cord-018834-4ligp4ak	35	17	-	-	HYPH
cord-018834-4ligp4ak	35	18	density	density	NN
cord-018834-4ligp4ak	35	19	lipoprotein	lipoprotein	NN
cord-018834-4ligp4ak	35	20	(	(	-LRB-
cord-018834-4ligp4ak	35	21	HDL	HDL	NNP
cord-018834-4ligp4ak	35	22	)	)	-RRB-
cord-018834-4ligp4ak	36	1	(	(	-LRB-
cord-018834-4ligp4ak	36	2	Apo	Apo	NNP
cord-018834-4ligp4ak	36	3	lipoprotein	lipoprotein	NN
cord-018834-4ligp4ak	36	4	M	M	NNP
cord-018834-4ligp4ak	36	5	is	be	VBZ
cord-018834-4ligp4ak	36	6	the	the	DT
cord-018834-4ligp4ak	36	7	principal	principal	JJ
cord-018834-4ligp4ak	36	8	partner	partner	NN
cord-018834-4ligp4ak	36	9	of	of	IN
cord-018834-4ligp4ak	36	10	S1P	s1p	CD
cord-018834-4ligp4ak	36	11	in	in	IN
cord-018834-4ligp4ak	36	12	HDL	HDL	NNP
cord-018834-4ligp4ak	36	13	)	)	-RRB-
cord-018834-4ligp4ak	36	14	and	and	CC
cord-018834-4ligp4ak	36	15	HSA	HSA	NNP
cord-018834-4ligp4ak	36	16	,	,	,
cord-018834-4ligp4ak	36	17	and	and	CC
cord-018834-4ligp4ak	36	18	this	this	DT
cord-018834-4ligp4ak	36	19	ensures	ensure	VBZ
cord-018834-4ligp4ak	36	20	a	a	DT
cord-018834-4ligp4ak	36	21	constant	constant	JJ
cord-018834-4ligp4ak	36	22	supply	supply	NN
cord-018834-4ligp4ak	36	23	of	of	IN
cord-018834-4ligp4ak	36	24	receptor	receptor	NN
cord-018834-4ligp4ak	36	25	-	-	HYPH
cord-018834-4ligp4ak	36	26	available	available	JJ
cord-018834-4ligp4ak	36	27	S1P	s1p	NN
cord-018834-4ligp4ak	36	28	for	for	IN
cord-018834-4ligp4ak	36	29	cellular	cellular	JJ
cord-018834-4ligp4ak	36	30	signaling	signaling	NN
cord-018834-4ligp4ak	36	31	purposes	purpose	NNS
cord-018834-4ligp4ak	36	32	.	.	.
cord-018834-4ligp4ak	37	1	In	in	IN
cord-018834-4ligp4ak	37	2	contrast	contrast	NN
cord-018834-4ligp4ak	37	3	to	to	IN
cord-018834-4ligp4ak	37	4	the	the	DT
cord-018834-4ligp4ak	37	5	bond	bond	NN
cord-018834-4ligp4ak	37	6	formed	form	VBN
cord-018834-4ligp4ak	37	7	between	between	IN
cord-018834-4ligp4ak	37	8	S1P	s1p	NN
cord-018834-4ligp4ak	37	9	and	and	CC
cord-018834-4ligp4ak	37	10	HDL	HDL	NNP
cord-018834-4ligp4ak	37	11	,	,	,
cord-018834-4ligp4ak	37	12	HSA	HSA	NNP
cord-018834-4ligp4ak	37	13	facilitates	facilitate	VBZ
cord-018834-4ligp4ak	37	14	the	the	DT
cord-018834-4ligp4ak	37	15	solubility	solubility	NN
cord-018834-4ligp4ak	37	16	of	of	IN
cord-018834-4ligp4ak	37	17	S1P	s1p	CD
cord-018834-4ligp4ak	37	18	in	in	IN
cord-018834-4ligp4ak	37	19	the	the	DT
cord-018834-4ligp4ak	37	20	aqueous	aqueous	JJ
cord-018834-4ligp4ak	37	21	solution	solution	NN
cord-018834-4ligp4ak	37	22	but	but	CC
cord-018834-4ligp4ak	37	23	not	not	RB
cord-018834-4ligp4ak	37	24	in	in	IN
cord-018834-4ligp4ak	37	25	physical	physical	JJ
cord-018834-4ligp4ak	37	26	bond	bond	NN
cord-018834-4ligp4ak	37	27	to	to	IN
cord-018834-4ligp4ak	37	28	HSA	HSA	NNP
cord-018834-4ligp4ak	37	29	.	.	.
cord-018834-4ligp4ak	38	1	This	this	DT
cord-018834-4ligp4ak	38	2	unbound	unbound	JJ
cord-018834-4ligp4ak	38	3	S1P	s1p	NN
cord-018834-4ligp4ak	38	4	is	be	VBZ
cord-018834-4ligp4ak	38	5	the	the	DT
cord-018834-4ligp4ak	38	6	active	active	JJ
cord-018834-4ligp4ak	38	7	form	form	NN
cord-018834-4ligp4ak	38	8	of	of	IN
cord-018834-4ligp4ak	38	9	S1P.	S1P.	NNP
cord-018834-4ligp4ak	39	1	It	-PRON-	PRP
cord-018834-4ligp4ak	39	2	is	be	VBZ
cord-018834-4ligp4ak	39	3	worth	worth	JJ
cord-018834-4ligp4ak	39	4	mentioning	mention	VBG
cord-018834-4ligp4ak	39	5	that	that	IN
cord-018834-4ligp4ak	39	6	one	one	CD
cord-018834-4ligp4ak	39	7	S1P	s1p	NN
cord-018834-4ligp4ak	39	8	molecule	molecule	NN
cord-018834-4ligp4ak	39	9	is	be	VBZ
cord-018834-4ligp4ak	39	10	extracted	extract	VBN
cord-018834-4ligp4ak	39	11	by	by	IN
cord-018834-4ligp4ak	39	12	500	500	CD
cord-018834-4ligp4ak	39	13	serum	serum	NN
cord-018834-4ligp4ak	39	14	albumin	albumin	NN
cord-018834-4ligp4ak	39	15	molecules	molecule	NNS
cord-018834-4ligp4ak	39	16	,	,	,
cord-018834-4ligp4ak	39	17	indicating	indicate	VBG
cord-018834-4ligp4ak	39	18	that	that	IN
cord-018834-4ligp4ak	39	19	HSA	HSA	NNP
cord-018834-4ligp4ak	39	20	does	do	VBZ
cord-018834-4ligp4ak	39	21	not	not	RB
cord-018834-4ligp4ak	39	22	physically	physically	RB
cord-018834-4ligp4ak	39	23	bind	bind	VB
cord-018834-4ligp4ak	39	24	S1P	s1p	CD
cord-018834-4ligp4ak	39	25	[	[	-LRB-
cord-018834-4ligp4ak	39	26	7	7	CD
cord-018834-4ligp4ak	39	27	-9	-9	ADD
cord-018834-4ligp4ak	39	28	]	]	-RRB-
cord-018834-4ligp4ak	39	29	.	.	.
cord-018834-4ligp4ak	40	1	S1P	S1P	NNP
cord-018834-4ligp4ak	40	2	activates	activate	VBZ
cord-018834-4ligp4ak	40	3	the	the	DT
cord-018834-4ligp4ak	40	4	G	G	NNP
cord-018834-4ligp4ak	40	5	protein	protein	NN
cord-018834-4ligp4ak	40	6	-	-	HYPH
cord-018834-4ligp4ak	40	7	coupled	couple	VBN
cord-018834-4ligp4ak	40	8	S1P1	S1P1	NNP
cord-018834-4ligp4ak	40	9	receptor	receptor	NN
cord-018834-4ligp4ak	40	10	,	,	,
cord-018834-4ligp4ak	40	11	which	which	WDT
cord-018834-4ligp4ak	40	12	rapidly	rapidly	RB
cord-018834-4ligp4ak	40	13	activates	activate	VBZ
cord-018834-4ligp4ak	40	14	the	the	DT
cord-018834-4ligp4ak	40	15	Rho	Rho	NNP
cord-018834-4ligp4ak	40	16	family	family	NN
cord-018834-4ligp4ak	40	17	small	small	JJ
cord-018834-4ligp4ak	40	18	GTPase	GTPase	NNP
cord-018834-4ligp4ak	40	19	Rac1	Rac1	NNP
cord-018834-4ligp4ak	40	20	in	in	IN
cord-018834-4ligp4ak	40	21	the	the	DT
cord-018834-4ligp4ak	40	22	endothelial	endothelial	JJ
cord-018834-4ligp4ak	40	23	cells	cell	NNS
cord-018834-4ligp4ak	40	24	,	,	,
cord-018834-4ligp4ak	40	25	leading	lead	VBG
cord-018834-4ligp4ak	40	26	to	to	IN
cord-018834-4ligp4ak	40	27	peripheral	peripheral	JJ
cord-018834-4ligp4ak	40	28	localization	localization	NN
cord-018834-4ligp4ak	40	29	of	of	IN
cord-018834-4ligp4ak	40	30	cytoskeletal	cytoskeletal	JJ
cord-018834-4ligp4ak	40	31	effectors	effector	NNS
cord-018834-4ligp4ak	40	32	(	(	-LRB-
cord-018834-4ligp4ak	40	33	cortactin	cortactin	NNP
cord-018834-4ligp4ak	40	34	and	and	CC
cord-018834-4ligp4ak	40	35	nonmuscle	nonmuscle	NNP
cord-018834-4ligp4ak	40	36	myosin	myosin	NNP
cord-018834-4ligp4ak	40	37	light	light	NNP
cord-018834-4ligp4ak	40	38	chain	chain	NN
cord-018834-4ligp4ak	40	39	kinase	kinase	NN
cord-018834-4ligp4ak	40	40	)	)	-RRB-
cord-018834-4ligp4ak	40	41	.	.	.
cord-018834-4ligp4ak	41	1	This	this	DT
cord-018834-4ligp4ak	41	2	localization	localization	NN
cord-018834-4ligp4ak	41	3	promotes	promote	VBZ
cord-018834-4ligp4ak	41	4	adherents	adherent	NNS
cord-018834-4ligp4ak	41	5	'	'	POS
cord-018834-4ligp4ak	41	6	junction	junction	NN
cord-018834-4ligp4ak	41	7	(	(	-LRB-
cord-018834-4ligp4ak	41	8	including	include	VBG
cord-018834-4ligp4ak	41	9	vascular	vascular	JJ
cord-018834-4ligp4ak	41	10	endothelial	endothelial	JJ
cord-018834-4ligp4ak	41	11	-	-	HYPH
cord-018834-4ligp4ak	41	12	cadherin	cadherin	NN
cord-018834-4ligp4ak	41	13	and	and	CC
cord-018834-4ligp4ak	41	14	associated	associate	VBD
cord-018834-4ligp4ak	41	15	catenins	catenins	NNP
cord-018834-4ligp4ak	41	16	)	)	-RRB-
cord-018834-4ligp4ak	41	17	and	and	CC
cord-018834-4ligp4ak	41	18	tight	tight	JJ
cord-018834-4ligp4ak	41	19	junction	junction	NN
cord-018834-4ligp4ak	41	20	(	(	-LRB-
cord-018834-4ligp4ak	41	21	occluding	occlude	VBG
cord-018834-4ligp4ak	41	22	,	,	,
cord-018834-4ligp4ak	41	23	zonula	zonula	NNP
cord-018834-4ligp4ak	41	24	occludens	occluden	VBD
cord-018834-4ligp4ak	41	25	proteins	protein	NNS
cord-018834-4ligp4ak	41	26	and	and	CC
cord-018834-4ligp4ak	41	27	claudins	claudin	NNS
cord-018834-4ligp4ak	41	28	)	)	-RRB-
cord-018834-4ligp4ak	41	29	formation	formation	NN
cord-018834-4ligp4ak	41	30	.	.	.
cord-018834-4ligp4ak	42	1	Therefore	therefore	RB
cord-018834-4ligp4ak	42	2	,	,	,
cord-018834-4ligp4ak	42	3	S1P	s1p	NN
cord-018834-4ligp4ak	42	4	improves	improve	VBZ
cord-018834-4ligp4ak	42	5	the	the	DT
cord-018834-4ligp4ak	42	6	vascular	vascular	JJ
cord-018834-4ligp4ak	42	7	barrier	barrier	NN
cord-018834-4ligp4ak	42	8	and	and	CC
cord-018834-4ligp4ak	42	9	stabilizes	stabilize	VBZ
cord-018834-4ligp4ak	42	10	the	the	DT
cord-018834-4ligp4ak	42	11	endothelial	endothelial	JJ
cord-018834-4ligp4ak	42	12	glycocalyx	glycocalyx	NN
cord-018834-4ligp4ak	42	13	.	.	.
cord-018834-4ligp4ak	43	1	S1P	S1P	NNP
cord-018834-4ligp4ak	43	2	has	have	VBZ
cord-018834-4ligp4ak	43	3	been	be	VBN
cord-018834-4ligp4ak	43	4	found	find	VBN
cord-018834-4ligp4ak	43	5	to	to	TO
cord-018834-4ligp4ak	43	6	reduce	reduce	VB
cord-018834-4ligp4ak	43	7	matrix	matrix	NN
cord-018834-4ligp4ak	43	8	metalloproteinase	metalloproteinase	NN
cord-018834-4ligp4ak	43	9	activation	activation	NN
cord-018834-4ligp4ak	43	10	,	,	,
cord-018834-4ligp4ak	43	11	thereby	thereby	RB
cord-018834-4ligp4ak	43	12	attenuating	attenuate	VBG
cord-018834-4ligp4ak	43	13	the	the	DT
cord-018834-4ligp4ak	43	14	loss	loss	NN
cord-018834-4ligp4ak	43	15	of	of	IN
cord-018834-4ligp4ak	43	16	endothelial	endothelial	JJ
cord-018834-4ligp4ak	43	17	cell	cell	NN
cord-018834-4ligp4ak	43	18	surface	surface	NN
cord-018834-4ligp4ak	43	19	glycocalyx	glycocalyx	NNP
cord-018834-4ligp4ak	43	20	components	component	NNS
cord-018834-4ligp4ak	43	21	.	.	.
cord-018834-4ligp4ak	44	1	Both	both	DT
cord-018834-4ligp4ak	44	2	actions	action	NNS
cord-018834-4ligp4ak	44	3	appear	appear	VBP
cord-018834-4ligp4ak	44	4	to	to	TO
cord-018834-4ligp4ak	44	5	involve	involve	VB
cord-018834-4ligp4ak	44	6	signaling	signal	VBG
cord-018834-4ligp4ak	44	7	via	via	IN
cord-018834-4ligp4ak	44	8	the	the	DT
cord-018834-4ligp4ak	44	9	S1P	s1p	NN
cord-018834-4ligp4ak	44	10	receptor	receptor	NN
cord-018834-4ligp4ak	44	11	[	[	-LRB-
cord-018834-4ligp4ak	44	12	10	10	CD
cord-018834-4ligp4ak	44	13	]	]	-RRB-
cord-018834-4ligp4ak	44	14	.	.	.
cord-018834-4ligp4ak	45	1	Oxidative	oxidative	JJ
cord-018834-4ligp4ak	45	2	stress	stress	NN
cord-018834-4ligp4ak	45	3	is	be	VBZ
cord-018834-4ligp4ak	45	4	defi	defi	NNP
cord-018834-4ligp4ak	45	5	ned	ned	NNP
cord-018834-4ligp4ak	45	6	as	as	IN
cord-018834-4ligp4ak	45	7	a	a	DT
cord-018834-4ligp4ak	45	8	disturbance	disturbance	NN
cord-018834-4ligp4ak	45	9	in	in	IN
cord-018834-4ligp4ak	45	10	pro	pro	JJ
cord-018834-4ligp4ak	45	11	-	-	JJ
cord-018834-4ligp4ak	45	12	oxidant	oxidant	JJ
cord-018834-4ligp4ak	45	13	and	and	CC
cord-018834-4ligp4ak	45	14	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	45	15	balance	balance	NN
cord-018834-4ligp4ak	45	16	leading	lead	VBG
cord-018834-4ligp4ak	45	17	to	to	IN
cord-018834-4ligp4ak	45	18	damage	damage	NN
cord-018834-4ligp4ak	45	19	of	of	IN
cord-018834-4ligp4ak	45	20	lipids	lipid	NNS
cord-018834-4ligp4ak	45	21	,	,	,
cord-018834-4ligp4ak	45	22	proteins	protein	NNS
cord-018834-4ligp4ak	45	23	,	,	,
cord-018834-4ligp4ak	45	24	and	and	CC
cord-018834-4ligp4ak	45	25	nucleic	nucleic	JJ
cord-018834-4ligp4ak	45	26	acids	acid	NNS
cord-018834-4ligp4ak	45	27	.	.	.
cord-018834-4ligp4ak	46	1	According	accord	VBG
cord-018834-4ligp4ak	46	2	to	to	IN
cord-018834-4ligp4ak	46	3	Halliwell	Halliwell	NNP
cord-018834-4ligp4ak	46	4	and	and	CC
cord-018834-4ligp4ak	46	5	Whiteman	Whiteman	NNP
cord-018834-4ligp4ak	46	6	,	,	,
cord-018834-4ligp4ak	46	7	an	an	DT
cord-018834-4ligp4ak	46	8	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	46	9	is	be	VBZ
cord-018834-4ligp4ak	46	10	a	a	DT
cord-018834-4ligp4ak	46	11	substance	substance	NN
cord-018834-4ligp4ak	46	12	that	that	WDT
cord-018834-4ligp4ak	46	13	,	,	,
cord-018834-4ligp4ak	46	14	when	when	WRB
cord-018834-4ligp4ak	46	15	present	present	JJ
cord-018834-4ligp4ak	46	16	at	at	IN
cord-018834-4ligp4ak	46	17	low	low	JJ
cord-018834-4ligp4ak	46	18	concentrations	concentration	NNS
cord-018834-4ligp4ak	46	19	compared	compare	VBN
cord-018834-4ligp4ak	46	20	with	with	IN
cord-018834-4ligp4ak	46	21	those	those	DT
cord-018834-4ligp4ak	46	22	of	of	IN
cord-018834-4ligp4ak	46	23	an	an	DT
cord-018834-4ligp4ak	46	24	oxidizable	oxidizable	JJ
cord-018834-4ligp4ak	46	25	substrate	substrate	NN
cord-018834-4ligp4ak	46	26	,	,	,
cord-018834-4ligp4ak	46	27	signifi	signifi	NNP
cord-018834-4ligp4ak	46	28	cantly	cantly	NN
cord-018834-4ligp4ak	46	29	delays	delay	NNS
cord-018834-4ligp4ak	46	30	or	or	CC
cord-018834-4ligp4ak	46	31	prevents	prevent	VBZ
cord-018834-4ligp4ak	46	32	oxidation	oxidation	NN
cord-018834-4ligp4ak	46	33	of	of	IN
cord-018834-4ligp4ak	46	34	that	that	DT
cord-018834-4ligp4ak	46	35	substrate	substrate	NN
cord-018834-4ligp4ak	46	36	[	[	-LRB-
cord-018834-4ligp4ak	46	37	11	11	CD
cord-018834-4ligp4ak	46	38	]	]	-RRB-
cord-018834-4ligp4ak	46	39	.	.	.
cord-018834-4ligp4ak	47	1	Human	human	JJ
cord-018834-4ligp4ak	47	2	serum	serum	NN
cord-018834-4ligp4ak	47	3	albumin	albumin	NN
cord-018834-4ligp4ak	47	4	represents	represent	VBZ
cord-018834-4ligp4ak	47	5	a	a	DT
cord-018834-4ligp4ak	47	6	major	major	JJ
cord-018834-4ligp4ak	47	7	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	47	8	agent	agent	NN
cord-018834-4ligp4ak	47	9	in	in	IN
cord-018834-4ligp4ak	47	10	human	human	JJ
cord-018834-4ligp4ak	47	11	plasma	plasma	NN
cord-018834-4ligp4ak	47	12	.	.	.
cord-018834-4ligp4ak	48	1	The	the	DT
cord-018834-4ligp4ak	48	2	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	48	3	activity	activity	NN
cord-018834-4ligp4ak	48	4	of	of	IN
cord-018834-4ligp4ak	48	5	HAS	have	VBZ
cord-018834-4ligp4ak	48	6	results	result	NNS
cord-018834-4ligp4ak	48	7	from	from	IN
cord-018834-4ligp4ak	48	8	the	the	DT
cord-018834-4ligp4ak	48	9	redox	redox	JJ
cord-018834-4ligp4ak	48	10	properties	property	NNS
cord-018834-4ligp4ak	48	11	of	of	IN
cord-018834-4ligp4ak	48	12	the	the	DT
cord-018834-4ligp4ak	48	13	Cysteine	Cysteine	NNP
cord-018834-4ligp4ak	48	14	34	34	CD
cord-018834-4ligp4ak	48	15	(	(	-LRB-
cord-018834-4ligp4ak	48	16	Cys	Cys	NNP
cord-018834-4ligp4ak	48	17	34	34	CD
cord-018834-4ligp4ak	48	18	)	)	-RRB-
cord-018834-4ligp4ak	48	19	and	and	CC
cord-018834-4ligp4ak	48	20	from	from	IN
cord-018834-4ligp4ak	48	21	metal	metal	NN
cord-018834-4ligp4ak	48	22	-	-	HYPH
cord-018834-4ligp4ak	48	23	binding	bind	VBG
cord-018834-4ligp4ak	48	24	abilities	ability	NNS
cord-018834-4ligp4ak	48	25	.	.	.
cord-018834-4ligp4ak	49	1	Among	among	IN
cord-018834-4ligp4ak	49	2	the	the	DT
cord-018834-4ligp4ak	49	3	metal	metal	NN
cord-018834-4ligp4ak	49	4	ligands	ligand	NNS
cord-018834-4ligp4ak	49	5	,	,	,
cord-018834-4ligp4ak	49	6	copper	copper	NN
cord-018834-4ligp4ak	49	7	(	(	-LRB-
cord-018834-4ligp4ak	49	8	Cu	cu	NN
cord-018834-4ligp4ak	49	9	)	)	-RRB-
cord-018834-4ligp4ak	49	10	and	and	CC
cord-018834-4ligp4ak	49	11	iron	iron	NN
cord-018834-4ligp4ak	49	12	(	(	-LRB-
cord-018834-4ligp4ak	49	13	Fe	Fe	NNP
cord-018834-4ligp4ak	49	14	)	)	-RRB-
cord-018834-4ligp4ak	49	15	are	be	VBP
cord-018834-4ligp4ak	49	16	very	very	RB
cord-018834-4ligp4ak	49	17	important	important	JJ
cord-018834-4ligp4ak	49	18	,	,	,
cord-018834-4ligp4ak	49	19	as	as	IN
cord-018834-4ligp4ak	49	20	they	-PRON-	PRP
cord-018834-4ligp4ak	49	21	are	be	VBP
cord-018834-4ligp4ak	49	22	able	able	JJ
cord-018834-4ligp4ak	49	23	to	to	TO
cord-018834-4ligp4ak	49	24	generate	generate	VB
cord-018834-4ligp4ak	49	25	reactive	reactive	JJ
cord-018834-4ligp4ak	49	26	oxygen	oxygen	NN
cord-018834-4ligp4ak	49	27	species	specie	NNS
cord-018834-4ligp4ak	49	28	(	(	-LRB-
cord-018834-4ligp4ak	49	29	ROS	ROS	NNP
cord-018834-4ligp4ak	49	30	)	)	-RRB-
cord-018834-4ligp4ak	49	31	after	after	IN
cord-018834-4ligp4ak	49	32	a	a	DT
cord-018834-4ligp4ak	49	33	reaction	reaction	NN
cord-018834-4ligp4ak	49	34	with	with	IN
cord-018834-4ligp4ak	49	35	oxygen	oxygen	NN
cord-018834-4ligp4ak	49	36	.	.	.
cord-018834-4ligp4ak	50	1	Free	Free	NNP
cord-018834-4ligp4ak	50	2	Cu	Cu	NNP
cord-018834-4ligp4ak	50	3	(	(	-LRB-
cord-018834-4ligp4ak	50	4	I	i	NN
cord-018834-4ligp4ak	50	5	)	)	-RRB-
cord-018834-4ligp4ak	50	6	and	and	CC
cord-018834-4ligp4ak	50	7	Fe	Fe	NNP
cord-018834-4ligp4ak	50	8	(	(	-LRB-
cord-018834-4ligp4ak	50	9	II	II	NNP
cord-018834-4ligp4ak	50	10	)	)	-RRB-
cord-018834-4ligp4ak	50	11	ions	ion	NNS
cord-018834-4ligp4ak	50	12	can	can	MD
cord-018834-4ligp4ak	50	13	react	react	VB
cord-018834-4ligp4ak	50	14	with	with	IN
cord-018834-4ligp4ak	50	15	H	h	NN
cord-018834-4ligp4ak	50	16	2	2	CD
cord-018834-4ligp4ak	50	17	O	o	NN
cord-018834-4ligp4ak	50	18	2	2	CD
cord-018834-4ligp4ak	50	19	leading	lead	VBG
cord-018834-4ligp4ak	50	20	to	to	IN
cord-018834-4ligp4ak	50	21	the	the	DT
cord-018834-4ligp4ak	50	22	formation	formation	NN
cord-018834-4ligp4ak	50	23	of	of	IN
cord-018834-4ligp4ak	50	24	the	the	DT
cord-018834-4ligp4ak	50	25	deleterious	deleterious	JJ
cord-018834-4ligp4ak	50	26	hydroxyl	hydroxyl	NN
cord-018834-4ligp4ak	50	27	radical	radical	JJ
cord-018834-4ligp4ak	50	28	via	via	IN
cord-018834-4ligp4ak	50	29	the	the	DT
cord-018834-4ligp4ak	50	30	Fenton	Fenton	NNP
cord-018834-4ligp4ak	50	31	reaction	reaction	NN
cord-018834-4ligp4ak	50	32	.	.	.
cord-018834-4ligp4ak	51	1	Cu(I	Cu(I	NNP
cord-018834-4ligp4ak	51	2	)	)	-RRB-
cord-018834-4ligp4ak	51	3	and	and	CC
cord-018834-4ligp4ak	51	4	Fe(II	fe(ii	NN
cord-018834-4ligp4ak	51	5	)	)	-RRB-
cord-018834-4ligp4ak	52	1	binding	bind	VBG
cord-018834-4ligp4ak	52	2	to	to	IN
cord-018834-4ligp4ak	52	3	HSA	HSA	NNP
cord-018834-4ligp4ak	52	4	promotes	promote	VBZ
cord-018834-4ligp4ak	52	5	their	-PRON-	PRP$
cord-018834-4ligp4ak	52	6	oxidation	oxidation	NN
cord-018834-4ligp4ak	52	7	to	to	IN
cord-018834-4ligp4ak	52	8	Cu(II	cu(ii	NN
cord-018834-4ligp4ak	52	9	)	)	-RRB-
cord-018834-4ligp4ak	52	10	and	and	CC
cord-018834-4ligp4ak	52	11	Fe	Fe	NNP
cord-018834-4ligp4ak	52	12	(	(	-LRB-
cord-018834-4ligp4ak	52	13	III	III	NNP
cord-018834-4ligp4ak	52	14	)	)	-RRB-
cord-018834-4ligp4ak	52	15	,	,	,
cord-018834-4ligp4ak	52	16	thereby	thereby	RB
cord-018834-4ligp4ak	52	17	limiting	limit	VBG
cord-018834-4ligp4ak	52	18	their	-PRON-	PRP$
cord-018834-4ligp4ak	52	19	ability	ability	NN
cord-018834-4ligp4ak	52	20	to	to	TO
cord-018834-4ligp4ak	52	21	participate	participate	VB
cord-018834-4ligp4ak	52	22	in	in	IN
cord-018834-4ligp4ak	52	23	Fenton	Fenton	NNP
cord-018834-4ligp4ak	52	24	reaction	reaction	NN
cord-018834-4ligp4ak	52	25	.	.	.
cord-018834-4ligp4ak	53	1	Copper	copper	NN
cord-018834-4ligp4ak	53	2	ions	ion	NNS
cord-018834-4ligp4ak	53	3	bind	bind	VBP
cord-018834-4ligp4ak	53	4	to	to	IN
cord-018834-4ligp4ak	53	5	HSA	HSA	NNP
cord-018834-4ligp4ak	53	6	with	with	IN
cord-018834-4ligp4ak	53	7	high	high	JJ
cord-018834-4ligp4ak	53	8	affi	affi	NNP
cord-018834-4ligp4ak	53	9	nity	nity	NN
cord-018834-4ligp4ak	53	10	at	at	IN
cord-018834-4ligp4ak	53	11	the	the	DT
cord-018834-4ligp4ak	53	12	N	n	CD
cord-018834-4ligp4ak	53	13	-	-	HYPH
cord-018834-4ligp4ak	53	14	terminal	terminal	NN
cord-018834-4ligp4ak	53	15	tripeptide	tripeptide	NN
cord-018834-4ligp4ak	54	1	Asp-	Asp-	NNP
cord-018834-4ligp4ak	55	1	Ala	Ala	NNP
cord-018834-4ligp4ak	55	2	-	-	:
cord-018834-4ligp4ak	55	3	His	His	NNP
cord-018834-4ligp4ak	55	4	.	.	.
cord-018834-4ligp4ak	56	1	The	the	DT
cord-018834-4ligp4ak	56	2	fi	fi	NN
cord-018834-4ligp4ak	56	3	rst	rst	NN
cord-018834-4ligp4ak	56	4	four	four	CD
cord-018834-4ligp4ak	56	5	amino	amino	NN
cord-018834-4ligp4ak	56	6	acids	acid	NNS
cord-018834-4ligp4ak	56	7	of	of	IN
cord-018834-4ligp4ak	56	8	the	the	DT
cord-018834-4ligp4ak	56	9	N	n	CD
cord-018834-4ligp4ak	56	10	-	-	HYPH
cord-018834-4ligp4ak	56	11	terminus	terminus	NN
cord-018834-4ligp4ak	56	12	of	of	IN
cord-018834-4ligp4ak	56	13	HSA	HSA	NNP
cord-018834-4ligp4ak	56	14	,	,	,
cord-018834-4ligp4ak	56	15	Asp	Asp	NNP
cord-018834-4ligp4ak	56	16	-	-	HYPH
cord-018834-4ligp4ak	56	17	Ala	Ala	NNP
cord-018834-4ligp4ak	56	18	-	-	HYPH
cord-018834-4ligp4ak	56	19	His	His	NNP
cord-018834-4ligp4ak	56	20	-	-	HYPH
cord-018834-4ligp4ak	56	21	Lys	Lys	NNP
cord-018834-4ligp4ak	56	22	(	(	-LRB-
cord-018834-4ligp4ak	56	23	DAHK	DAHK	NNP
cord-018834-4ligp4ak	56	24	)	)	-RRB-
cord-018834-4ligp4ak	56	25	,	,	,
cord-018834-4ligp4ak	56	26	form	form	VB
cord-018834-4ligp4ak	56	27	a	a	DT
cord-018834-4ligp4ak	56	28	tight	tight	JJ
cord-018834-4ligp4ak	56	29	binding	binding	NN
cord-018834-4ligp4ak	56	30	site	site	NN
cord-018834-4ligp4ak	56	31	for	for	IN
cord-018834-4ligp4ak	56	32	Cu(II	cu(ii	NN
cord-018834-4ligp4ak	56	33	)	)	-RRB-
cord-018834-4ligp4ak	56	34	ions	ion	NNS
cord-018834-4ligp4ak	56	35	.	.	.
cord-018834-4ligp4ak	57	1	DAHK	DAHK	NNP
cord-018834-4ligp4ak	57	2	/	/	SYM
cord-018834-4ligp4ak	57	3	Cu	Cu	NNP
cord-018834-4ligp4ak	57	4	has	have	VBZ
cord-018834-4ligp4ak	57	5	a	a	DT
cord-018834-4ligp4ak	57	6	superoxide	superoxide	NN
cord-018834-4ligp4ak	57	7	dismutase	dismutase	NN
cord-018834-4ligp4ak	57	8	activity	activity	NN
cord-018834-4ligp4ak	57	9	,	,	,
cord-018834-4ligp4ak	57	10	which	which	WDT
cord-018834-4ligp4ak	57	11	thereby	thereby	RB
cord-018834-4ligp4ak	57	12	reduces	reduce	VBZ
cord-018834-4ligp4ak	57	13	the	the	DT
cord-018834-4ligp4ak	57	14	ROS	ROS	NNP
cord-018834-4ligp4ak	57	15	generation	generation	NN
cord-018834-4ligp4ak	57	16	.	.	.
cord-018834-4ligp4ak	58	1	By	by	IN
cord-018834-4ligp4ak	58	2	trapping	trap	VBG
cord-018834-4ligp4ak	58	3	Cu(II	Cu(II	NNP
cord-018834-4ligp4ak	58	4	)	)	-RRB-
cord-018834-4ligp4ak	58	5	,	,	,
cord-018834-4ligp4ak	58	6	HSA	HSA	NNP
cord-018834-4ligp4ak	58	7	prevents	prevent	VBZ
cord-018834-4ligp4ak	58	8	low	low	JJ
cord-018834-4ligp4ak	58	9	-	-	HYPH
cord-018834-4ligp4ak	58	10	density	density	NN
cord-018834-4ligp4ak	58	11	lipoprotein	lipoprotein	NN
cord-018834-4ligp4ak	58	12	(	(	-LRB-
cord-018834-4ligp4ak	58	13	LDL	LDL	NNP
cord-018834-4ligp4ak	58	14	)	)	-RRB-
cord-018834-4ligp4ak	58	15	lipid	lipid	NN
cord-018834-4ligp4ak	58	16	peroxidation	peroxidation	NN
cord-018834-4ligp4ak	58	17	.	.	.
cord-018834-4ligp4ak	59	1	Moreover	moreover	RB
cord-018834-4ligp4ak	59	2	,	,	,
cord-018834-4ligp4ak	59	3	HSA	HSA	NNP
cord-018834-4ligp4ak	59	4	and	and	CC
cord-018834-4ligp4ak	59	5	the	the	DT
cord-018834-4ligp4ak	59	6	tetrapeptide	tetrapeptide	NN
cord-018834-4ligp4ak	59	7	(	(	-LRB-
cord-018834-4ligp4ak	59	8	DAHK	DAHK	NNP
cord-018834-4ligp4ak	59	9	)	)	-RRB-
cord-018834-4ligp4ak	59	10	were	be	VBD
cord-018834-4ligp4ak	59	11	shown	show	VBN
cord-018834-4ligp4ak	59	12	to	to	TO
cord-018834-4ligp4ak	59	13	prevent	prevent	VB
cord-018834-4ligp4ak	59	14	neuronal	neuronal	JJ
cord-018834-4ligp4ak	59	15	death	death	NN
cord-018834-4ligp4ak	59	16	in	in	IN
cord-018834-4ligp4ak	59	17	murine	murine	JJ
cord-018834-4ligp4ak	59	18	cell	cell	NN
cord-018834-4ligp4ak	59	19	cultures	culture	NNS
cord-018834-4ligp4ak	59	20	exposed	expose	VBN
cord-018834-4ligp4ak	59	21	to	to	IN
cord-018834-4ligp4ak	59	22	oxidative	oxidative	JJ
cord-018834-4ligp4ak	59	23	stress	stress	NN
cord-018834-4ligp4ak	59	24	generated	generate	VBN
cord-018834-4ligp4ak	59	25	by	by	IN
cord-018834-4ligp4ak	59	26	H	h	NN
cord-018834-4ligp4ak	59	27	2	2	CD
cord-018834-4ligp4ak	59	28	O	o	NN
cord-018834-4ligp4ak	59	29	2	2	CD
cord-018834-4ligp4ak	59	30	/Cu(I)/ascorbic	/cu(i)/ascorbic	JJ
cord-018834-4ligp4ak	59	31	acid	acid	NN
cord-018834-4ligp4ak	59	32	reagent	reagent	NN
cord-018834-4ligp4ak	59	33	[	[	-LRB-
cord-018834-4ligp4ak	59	34	12	12	CD
cord-018834-4ligp4ak	59	35	]	]	-RRB-
cord-018834-4ligp4ak	59	36	.	.	.
cord-018834-4ligp4ak	60	1	Therefore	therefore	RB
cord-018834-4ligp4ak	60	2	,	,	,
cord-018834-4ligp4ak	60	3	the	the	DT
cord-018834-4ligp4ak	60	4	binding	binding	NN
cord-018834-4ligp4ak	60	5	of	of	IN
cord-018834-4ligp4ak	60	6	Cu	Cu	NNP
cord-018834-4ligp4ak	60	7	ions	ion	NNS
cord-018834-4ligp4ak	60	8	with	with	IN
cord-018834-4ligp4ak	60	9	albumin	albumin	NN
cord-018834-4ligp4ak	60	10	is	be	VBZ
cord-018834-4ligp4ak	60	11	considered	consider	VBN
cord-018834-4ligp4ak	60	12	one	one	CD
cord-018834-4ligp4ak	60	13	of	of	IN
cord-018834-4ligp4ak	60	14	the	the	DT
cord-018834-4ligp4ak	60	15	most	most	RBS
cord-018834-4ligp4ak	60	16	important	important	JJ
cord-018834-4ligp4ak	60	17	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	60	18	functions	function	NNS
cord-018834-4ligp4ak	60	19	of	of	IN
cord-018834-4ligp4ak	60	20	albumin	albumin	NN
cord-018834-4ligp4ak	60	21	as	as	IN
cord-018834-4ligp4ak	60	22	Cu	Cu	NNP
cord-018834-4ligp4ak	60	23	can	can	MD
cord-018834-4ligp4ak	60	24	react	react	VB
cord-018834-4ligp4ak	60	25	with	with	IN
cord-018834-4ligp4ak	60	26	H	h	NN
cord-018834-4ligp4ak	60	27	2	2	CD
cord-018834-4ligp4ak	60	28	O	o	NN
cord-018834-4ligp4ak	60	29	2	2	CD
cord-018834-4ligp4ak	60	30	to	to	IN
cord-018834-4ligp4ak	60	31	hydroxyl	hydroxyl	NN
cord-018834-4ligp4ak	60	32	radicals	radical	NNS
cord-018834-4ligp4ak	60	33	60	60	CD
cord-018834-4ligp4ak	60	34	times	time	NNS
cord-018834-4ligp4ak	60	35	faster	fast	RBR
cord-018834-4ligp4ak	60	36	than	than	IN
cord-018834-4ligp4ak	60	37	Fe	Fe	NNP
cord-018834-4ligp4ak	60	38	.	.	.
cord-018834-4ligp4ak	61	1	HSA	HSA	NNP
cord-018834-4ligp4ak	61	2	is	be	VBZ
cord-018834-4ligp4ak	61	3	important	important	JJ
cord-018834-4ligp4ak	61	4	for	for	IN
cord-018834-4ligp4ak	61	5	heme	heme	NN
cord-018834-4ligp4ak	61	6	-	-	HYPH
cord-018834-4ligp4ak	61	7	Fe	fe	NN
cord-018834-4ligp4ak	61	8	scavenging	scavenging	NN
cord-018834-4ligp4ak	61	9	,	,	,
cord-018834-4ligp4ak	61	10	providing	provide	VBG
cord-018834-4ligp4ak	61	11	protection	protection	NN
cord-018834-4ligp4ak	61	12	against	against	IN
cord-018834-4ligp4ak	61	13	free	free	JJ
cord-018834-4ligp4ak	61	14	heme	heme	NNP
cord-018834-4ligp4ak	61	15	-	-	HYPH
cord-018834-4ligp4ak	61	16	Fe	fe	JJ
cord-018834-4ligp4ak	61	17	oxidative	oxidative	JJ
cord-018834-4ligp4ak	61	18	damage	damage	NN
cord-018834-4ligp4ak	61	19	.	.	.
cord-018834-4ligp4ak	62	1	During	during	IN
cord-018834-4ligp4ak	62	2	the	the	DT
cord-018834-4ligp4ak	62	3	fi	fi	NN
cord-018834-4ligp4ak	62	4	rst	rst	NN
cord-018834-4ligp4ak	62	5	seconds	second	NNS
cord-018834-4ligp4ak	62	6	after	after	IN
cord-018834-4ligp4ak	62	7	heme	heme	NN
cord-018834-4ligp4ak	62	8	-	-	HYPH
cord-018834-4ligp4ak	62	9	Fe	fe	JJ
cord-018834-4ligp4ak	62	10	appearance	appearance	NN
cord-018834-4ligp4ak	62	11	in	in	IN
cord-018834-4ligp4ak	62	12	plasma	plasma	NN
cord-018834-4ligp4ak	62	13	,	,	,
cord-018834-4ligp4ak	62	14	more	more	JJR
cord-018834-4ligp4ak	62	15	than	than	IN
cord-018834-4ligp4ak	62	16	80	80	CD
cord-018834-4ligp4ak	62	17	%	%	NN
cord-018834-4ligp4ak	62	18	of	of	IN
cord-018834-4ligp4ak	62	19	this	this	DT
cord-018834-4ligp4ak	62	20	powerful	powerful	JJ
cord-018834-4ligp4ak	62	21	oxidizer	oxidizer	NN
cord-018834-4ligp4ak	62	22	binds	bind	VBZ
cord-018834-4ligp4ak	62	23	to	to	IN
cord-018834-4ligp4ak	62	24	HDL	HDL	NNP
cord-018834-4ligp4ak	62	25	and	and	CC
cord-018834-4ligp4ak	62	26	LDL	LDL	NNP
cord-018834-4ligp4ak	62	27	,	,	,
cord-018834-4ligp4ak	62	28	and	and	CC
cord-018834-4ligp4ak	62	29	only	only	RB
cord-018834-4ligp4ak	62	30	the	the	DT
cord-018834-4ligp4ak	62	31	remaining	remain	VBG
cord-018834-4ligp4ak	62	32	20	20	CD
cord-018834-4ligp4ak	62	33	%	%	NN
cord-018834-4ligp4ak	62	34	binds	bind	VBZ
cord-018834-4ligp4ak	62	35	to	to	IN
cord-018834-4ligp4ak	62	36	HSA	HSA	NNP
cord-018834-4ligp4ak	62	37	and	and	CC
cord-018834-4ligp4ak	62	38	hemopexin	hemopexin	NNP
cord-018834-4ligp4ak	62	39	(	(	-LRB-
cord-018834-4ligp4ak	62	40	HPX	HPX	NNP
cord-018834-4ligp4ak	62	41	)	)	-RRB-
cord-018834-4ligp4ak	62	42	.	.	.
cord-018834-4ligp4ak	63	1	Then	then	RB
cord-018834-4ligp4ak	63	2	,	,	,
cord-018834-4ligp4ak	63	3	HSA	HSA	NNP
cord-018834-4ligp4ak	63	4	and	and	CC
cord-018834-4ligp4ak	63	5	HPX	HPX	NNP
cord-018834-4ligp4ak	63	6	remove	remove	VB
cord-018834-4ligp4ak	63	7	most	most	JJS
cord-018834-4ligp4ak	63	8	of	of	IN
cord-018834-4ligp4ak	63	9	the	the	DT
cord-018834-4ligp4ak	63	10	heme	heme	NN
cord-018834-4ligp4ak	63	11	-	-	HYPH
cord-018834-4ligp4ak	63	12	Fe	Fe	NNP
cord-018834-4ligp4ak	63	13	from	from	IN
cord-018834-4ligp4ak	63	14	HDL	HDL	NNP
cord-018834-4ligp4ak	63	15	and	and	CC
cord-018834-4ligp4ak	63	16	LDL	LDL	NNP
cord-018834-4ligp4ak	63	17	.	.	.
cord-018834-4ligp4ak	64	1	Afterward	afterward	RB
cord-018834-4ligp4ak	64	2	,	,	,
cord-018834-4ligp4ak	64	3	heme	heme	NN
cord-018834-4ligp4ak	64	4	-	-	HYPH
cord-018834-4ligp4ak	64	5	Fe	fe	NN
cord-018834-4ligp4ak	64	6	transits	transit	NNS
cord-018834-4ligp4ak	64	7	from	from	IN
cord-018834-4ligp4ak	64	8	HSA	HSA	NNP
cord-018834-4ligp4ak	64	9	to	to	IN
cord-018834-4ligp4ak	64	10	HPX	HPX	NNP
cord-018834-4ligp4ak	64	11	,	,	,
cord-018834-4ligp4ak	64	12	which	which	WDT
cord-018834-4ligp4ak	64	13	releases	release	VBZ
cord-018834-4ligp4ak	64	14	it	-PRON-	PRP
cord-018834-4ligp4ak	64	15	into	into	IN
cord-018834-4ligp4ak	64	16	hepatic	hepatic	JJ
cord-018834-4ligp4ak	64	17	parenchymal	parenchymal	NN
cord-018834-4ligp4ak	64	18	cells	cell	NNS
cord-018834-4ligp4ak	64	19	after	after	IN
cord-018834-4ligp4ak	64	20	internalization	internalization	NN
cord-018834-4ligp4ak	64	21	of	of	IN
cord-018834-4ligp4ak	64	22	the	the	DT
cord-018834-4ligp4ak	64	23	HPX	HPX	NNP
cord-018834-4ligp4ak	64	24	-	-	HYPH
cord-018834-4ligp4ak	64	25	heme	heme	NNP
cord-018834-4ligp4ak	64	26	-	-	HYPH
cord-018834-4ligp4ak	64	27	Fe	fe	NN
cord-018834-4ligp4ak	64	28	complex	complex	NN
cord-018834-4ligp4ak	64	29	by	by	IN
cord-018834-4ligp4ak	64	30	CD91	CD91	NNP
cord-018834-4ligp4ak	64	31	receptor	receptor	NN
cord-018834-4ligp4ak	64	32	-	-	HYPH
cord-018834-4ligp4ak	64	33	mediated	mediate	VBN
cord-018834-4ligp4ak	64	34	endocytosis	endocytosis	NN
cord-018834-4ligp4ak	64	35	.	.	.
cord-018834-4ligp4ak	65	1	It	-PRON-	PRP
cord-018834-4ligp4ak	65	2	should	should	MD
cord-018834-4ligp4ak	65	3	be	be	VB
cord-018834-4ligp4ak	65	4	mentioned	mention	VBN
cord-018834-4ligp4ak	65	5	that	that	IN
cord-018834-4ligp4ak	65	6	kinetics	kinetic	NNS
cord-018834-4ligp4ak	65	7	of	of	IN
cord-018834-4ligp4ak	65	8	heme	heme	NN
cord-018834-4ligp4ak	65	9	-	-	HYPH
cord-018834-4ligp4ak	65	10	Fe	fe	NN
cord-018834-4ligp4ak	65	11	transfer	transfer	NN
cord-018834-4ligp4ak	65	12	from	from	IN
cord-018834-4ligp4ak	65	13	HDL	HDL	NNP
cord-018834-4ligp4ak	65	14	and	and	CC
cord-018834-4ligp4ak	65	15	LDL	LDL	NNP
cord-018834-4ligp4ak	65	16	to	to	IN
cord-018834-4ligp4ak	65	17	HSA	HSA	NNP
cord-018834-4ligp4ak	65	18	and	and	CC
cord-018834-4ligp4ak	65	19	HPX	HPX	NNP
cord-018834-4ligp4ak	65	20	is	be	VBZ
cord-018834-4ligp4ak	65	21	faster	fast	JJR
cord-018834-4ligp4ak	65	22	than	than	IN
cord-018834-4ligp4ak	65	23	the	the	DT
cord-018834-4ligp4ak	65	24	heme	heme	NN
cord-018834-4ligp4ak	65	25	-	-	HYPH
cord-018834-4ligp4ak	65	26	Fe	fe	NN
cord-018834-4ligp4ak	65	27	-	-	HYPH
cord-018834-4ligp4ak	65	28	induced	induce	VBN
cord-018834-4ligp4ak	65	29	lipoprotein	lipoprotein	NN
cord-018834-4ligp4ak	65	30	oxidation	oxidation	NN
cord-018834-4ligp4ak	65	31	[	[	-LRB-
cord-018834-4ligp4ak	65	32	13	13	CD
cord-018834-4ligp4ak	65	33	,	,	,
cord-018834-4ligp4ak	65	34	14	14	CD
cord-018834-4ligp4ak	65	35	]	]	-RRB-
cord-018834-4ligp4ak	65	36	.	.	.
cord-018834-4ligp4ak	66	1	Albumin	albumin	NN
cord-018834-4ligp4ak	66	2	-	-	HYPH
cord-018834-4ligp4ak	66	3	bound	bind	VBN
cord-018834-4ligp4ak	66	4	bilirubin	bilirubin	NN
cord-018834-4ligp4ak	66	5	confers	confer	VBZ
cord-018834-4ligp4ak	66	6	an	an	DT
cord-018834-4ligp4ak	66	7	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	66	8	effect	effect	NN
cord-018834-4ligp4ak	66	9	by	by	IN
cord-018834-4ligp4ak	66	10	inhibiting	inhibit	VBG
cord-018834-4ligp4ak	66	11	lipid	lipid	NN
cord-018834-4ligp4ak	66	12	peroxidation	peroxidation	NN
cord-018834-4ligp4ak	66	13	.	.	.
cord-018834-4ligp4ak	67	1	Bilirubin	bilirubin	NN
cord-018834-4ligp4ak	67	2	bound	bind	VBN
cord-018834-4ligp4ak	67	3	to	to	IN
cord-018834-4ligp4ak	67	4	albumin	albumin	NN
cord-018834-4ligp4ak	67	5	was	be	VBD
cord-018834-4ligp4ak	67	6	shown	show	VBN
cord-018834-4ligp4ak	67	7	to	to	TO
cord-018834-4ligp4ak	67	8	protect	protect	VB
cord-018834-4ligp4ak	67	9	α(alpha)-tocopherol	α(alpha)-tocopherol	NNP
cord-018834-4ligp4ak	67	10	from	from	IN
cord-018834-4ligp4ak	67	11	damage	damage	NN
cord-018834-4ligp4ak	67	12	mediated	mediate	VBN
cord-018834-4ligp4ak	67	13	by	by	IN
cord-018834-4ligp4ak	67	14	peroxyl	peroxyl	NN
cord-018834-4ligp4ak	67	15	radicals	radical	NNS
cord-018834-4ligp4ak	67	16	and	and	CC
cord-018834-4ligp4ak	67	17	to	to	TO
cord-018834-4ligp4ak	67	18	prolong	prolong	VB
cord-018834-4ligp4ak	67	19	the	the	DT
cord-018834-4ligp4ak	67	20	survival	survival	NN
cord-018834-4ligp4ak	67	21	of	of	IN
cord-018834-4ligp4ak	67	22	human	human	JJ
cord-018834-4ligp4ak	67	23	ven	ven	NNP
cord-018834-4ligp4ak	67	24	-	-	HYPH
cord-018834-4ligp4ak	67	25	tricular	tricular	NNP
cord-018834-4ligp4ak	67	26	myocytes	myocyte	NNS
cord-018834-4ligp4ak	67	27	against	against	IN
cord-018834-4ligp4ak	67	28	in	in	IN
cord-018834-4ligp4ak	67	29	situ	situ	NN
cord-018834-4ligp4ak	67	30	-	-	HYPH
cord-018834-4ligp4ak	67	31	generated	generate	VBN
cord-018834-4ligp4ak	67	32	oxidative	oxidative	JJ
cord-018834-4ligp4ak	67	33	stress	stress	NN
cord-018834-4ligp4ak	67	34	[	[	-LRB-
cord-018834-4ligp4ak	67	35	15	15	CD
cord-018834-4ligp4ak	67	36	,	,	,
cord-018834-4ligp4ak	67	37	16	16	CD
cord-018834-4ligp4ak	67	38	]	]	-RRB-
cord-018834-4ligp4ak	67	39	.	.	.
cord-018834-4ligp4ak	68	1	Cholesterol	cholesterol	NN
cord-018834-4ligp4ak	68	2	undergoes	undergo	VBZ
cord-018834-4ligp4ak	68	3	oxidation	oxidation	NN
cord-018834-4ligp4ak	68	4	in	in	IN
cord-018834-4ligp4ak	68	5	vitro	vitro	FW
cord-018834-4ligp4ak	68	6	and	and	CC
cord-018834-4ligp4ak	68	7	in	in	IN
cord-018834-4ligp4ak	68	8	vivo	vivo	NN
cord-018834-4ligp4ak	68	9	,	,	,
cord-018834-4ligp4ak	68	10	forming	form	VBG
cord-018834-4ligp4ak	68	11	biologically	biologically	RB
cord-018834-4ligp4ak	68	12	active	active	JJ
cord-018834-4ligp4ak	68	13	derivatives	derivative	NNS
cord-018834-4ligp4ak	68	14	known	know	VBN
cord-018834-4ligp4ak	68	15	as	as	IN
cord-018834-4ligp4ak	68	16	oxysterols	oxysterol	NNS
cord-018834-4ligp4ak	68	17	.	.	.
cord-018834-4ligp4ak	69	1	Oxysterols	oxysterol	NNS
cord-018834-4ligp4ak	69	2	bind	bind	VBP
cord-018834-4ligp4ak	69	3	to	to	IN
cord-018834-4ligp4ak	69	4	albumin	albumin	NN
cord-018834-4ligp4ak	69	5	with	with	IN
cord-018834-4ligp4ak	69	6	high	high	JJ
cord-018834-4ligp4ak	69	7	affi	affi	NNP
cord-018834-4ligp4ak	69	8	nity	nity	NN
cord-018834-4ligp4ak	69	9	.	.	.
cord-018834-4ligp4ak	70	1	Oxysterols	oxysterol	NNS
cord-018834-4ligp4ak	70	2	carried	carry	VBN
cord-018834-4ligp4ak	70	3	by	by	IN
cord-018834-4ligp4ak	70	4	albumin	albumin	NN
cord-018834-4ligp4ak	70	5	are	be	VBP
cord-018834-4ligp4ak	70	6	less	less	RBR
cord-018834-4ligp4ak	70	7	rapidly	rapidly	RB
cord-018834-4ligp4ak	70	8	released	release	VBN
cord-018834-4ligp4ak	70	9	to	to	IN
cord-018834-4ligp4ak	70	10	cells	cell	NNS
cord-018834-4ligp4ak	70	11	than	than	IN
cord-018834-4ligp4ak	70	12	cholesterol	cholesterol	NN
cord-018834-4ligp4ak	70	13	.	.	.
cord-018834-4ligp4ak	71	1	By	by	IN
cord-018834-4ligp4ak	71	2	this	this	DT
cord-018834-4ligp4ak	71	3	,	,	,
cord-018834-4ligp4ak	71	4	albumin	albumin	NN
cord-018834-4ligp4ak	71	5	could	could	MD
cord-018834-4ligp4ak	71	6	limit	limit	VB
cord-018834-4ligp4ak	71	7	detrimental	detrimental	JJ
cord-018834-4ligp4ak	71	8	effects	effect	NNS
cord-018834-4ligp4ak	71	9	of	of	IN
cord-018834-4ligp4ak	71	10	oxysterols	oxysterol	NNS
cord-018834-4ligp4ak	71	11	on	on	IN
cord-018834-4ligp4ak	71	12	cells	cell	NNS
cord-018834-4ligp4ak	71	13	.	.	.
cord-018834-4ligp4ak	72	1	Furthermore	furthermore	RB
cord-018834-4ligp4ak	72	2	,	,	,
cord-018834-4ligp4ak	72	3	binding	bind	VBG
cord-018834-4ligp4ak	72	4	homocysteine	homocysteine	NN
cord-018834-4ligp4ak	72	5	by	by	IN
cord-018834-4ligp4ak	72	6	HSA	HSA	NNP
cord-018834-4ligp4ak	72	7	protects	protect	VBZ
cord-018834-4ligp4ak	72	8	from	from	IN
cord-018834-4ligp4ak	72	9	atherosclerosis	atherosclerosis	NN
cord-018834-4ligp4ak	72	10	as	as	IN
cord-018834-4ligp4ak	72	11	elevated	elevated	JJ
cord-018834-4ligp4ak	72	12	plasma	plasma	NN
cord-018834-4ligp4ak	72	13	homocysteine	homocysteine	NN
cord-018834-4ligp4ak	72	14	is	be	VBZ
cord-018834-4ligp4ak	72	15	a	a	DT
cord-018834-4ligp4ak	72	16	well	well	RB
cord-018834-4ligp4ak	72	17	-	-	HYPH
cord-018834-4ligp4ak	72	18	known	know	VBN
cord-018834-4ligp4ak	72	19	risk	risk	NN
cord-018834-4ligp4ak	72	20	factor	factor	NN
cord-018834-4ligp4ak	72	21	for	for	IN
cord-018834-4ligp4ak	72	22	atherosclerosis	atherosclerosis	NN
cord-018834-4ligp4ak	72	23	(	(	-LRB-
cord-018834-4ligp4ak	72	24	Figs	fig	NNS
cord-018834-4ligp4ak	72	25	.	.	.
cord-018834-4ligp4ak	73	1	9.2	9.2	CD
cord-018834-4ligp4ak	73	2	and	and	CC
cord-018834-4ligp4ak	73	3	9.3	9.3	CD
cord-018834-4ligp4ak	73	4	)	)	-RRB-
cord-018834-4ligp4ak	73	5	[	[	-LRB-
cord-018834-4ligp4ak	73	6	17	17	CD
cord-018834-4ligp4ak	73	7	]	]	-RRB-
cord-018834-4ligp4ak	73	8	.	.	.
cord-018834-4ligp4ak	74	1	Physiologically	physiologically	RB
cord-018834-4ligp4ak	74	2	,	,	,
cord-018834-4ligp4ak	74	3	HAS	have	VBZ
cord-018834-4ligp4ak	74	4	exists	exist	VBZ
cord-018834-4ligp4ak	74	5	predominately	predominately	RB
cord-018834-4ligp4ak	74	6	in	in	IN
cord-018834-4ligp4ak	74	7	a	a	DT
cord-018834-4ligp4ak	74	8	reduced	reduce	VBN
cord-018834-4ligp4ak	74	9	form	form	NN
cord-018834-4ligp4ak	74	10	(	(	-LRB-
cord-018834-4ligp4ak	74	11	i.e.	i.e.	FW
cord-018834-4ligp4ak	74	12	,	,	,
cord-018834-4ligp4ak	74	13	with	with	IN
cord-018834-4ligp4ak	74	14	free	free	JJ
cord-018834-4ligp4ak	74	15	thiol	thiol	NN
cord-018834-4ligp4ak	74	16	,	,	,
cord-018834-4ligp4ak	74	17	HSA	HSA	NNP
cord-018834-4ligp4ak	74	18	-	-	HYPH
cord-018834-4ligp4ak	74	19	SH	SH	NNP
cord-018834-4ligp4ak	74	20	)	)	-RRB-
cord-018834-4ligp4ak	74	21	and	and	CC
cord-018834-4ligp4ak	74	22	is	be	VBZ
cord-018834-4ligp4ak	74	23	known	know	VBN
cord-018834-4ligp4ak	74	24	as	as	IN
cord-018834-4ligp4ak	74	25	mercapto	mercapto	VBN
cord-018834-4ligp4ak	74	26	-	-	HYPH
cord-018834-4ligp4ak	74	27	albumin	albumin	NN
cord-018834-4ligp4ak	74	28	.	.	.
cord-018834-4ligp4ak	75	1	However	however	RB
cord-018834-4ligp4ak	75	2	,	,	,
cord-018834-4ligp4ak	75	3	a	a	DT
cord-018834-4ligp4ak	75	4	small	small	JJ
cord-018834-4ligp4ak	75	5	but	but	CC
cord-018834-4ligp4ak	75	6	significant	significant	JJ
cord-018834-4ligp4ak	75	7	proportion	proportion	NN
cord-018834-4ligp4ak	75	8	of	of	IN
cord-018834-4ligp4ak	75	9	albumin	albumin	NN
cord-018834-4ligp4ak	75	10	pool	pool	NN
cord-018834-4ligp4ak	75	11	exists	exist	VBZ
cord-018834-4ligp4ak	75	12	as	as	IN
cord-018834-4ligp4ak	75	13	mixed	mixed	JJ
cord-018834-4ligp4ak	75	14	disulfi	disulfi	NN
cord-018834-4ligp4ak	75	15	des	des	FW
cord-018834-4ligp4ak	75	16	(	(	-LRB-
cord-018834-4ligp4ak	75	17	HSA	HSA	NNP
cord-018834-4ligp4ak	75	18	-	-	HYPH
cord-018834-4ligp4ak	75	19	S	S	NNP
cord-018834-4ligp4ak	75	20	-	-	HYPH
cord-018834-4ligp4ak	75	21	S	S	NNP
cord-018834-4ligp4ak	75	22	-	-	HYPH
cord-018834-4ligp4ak	75	23	R	R	NNP
cord-018834-4ligp4ak	75	24	)	)	-RRB-
cord-018834-4ligp4ak	75	25	;	;	:
cord-018834-4ligp4ak	75	26	where	where	WRB
cord-018834-4ligp4ak	75	27	R	r	NN
cord-018834-4ligp4ak	75	28	represents	represent	VBZ
cord-018834-4ligp4ak	75	29	low	low	JJ
cord-018834-4ligp4ak	75	30	-	-	HYPH
cord-018834-4ligp4ak	75	31	molecular	molecular	JJ
cord-018834-4ligp4ak	75	32	-	-	HYPH
cord-018834-4ligp4ak	75	33	weight	weight	NN
cord-018834-4ligp4ak	75	34	,	,	,
cord-018834-4ligp4ak	75	35	thiol	thiol	NN
cord-018834-4ligp4ak	75	36	-	-	HYPH
cord-018834-4ligp4ak	75	37	containing	contain	VBG
cord-018834-4ligp4ak	75	38	substances	substance	NNS
cord-018834-4ligp4ak	75	39	in	in	IN
cord-018834-4ligp4ak	75	40	plasma	plasma	NN
cord-018834-4ligp4ak	75	41	-chiefl	-chiefl	:
cord-018834-4ligp4ak	75	42	y	y	NNP
cord-018834-4ligp4ak	75	43	cysteine	cysteine	NN
cord-018834-4ligp4ak	75	44	and	and	CC
cord-018834-4ligp4ak	75	45	glutathione	glutathione	NN
cord-018834-4ligp4ak	76	1	[	[	-LRB-
cord-018834-4ligp4ak	76	2	18	18	CD
cord-018834-4ligp4ak	76	3	]	]	-RRB-
cord-018834-4ligp4ak	76	4	.	.	.
cord-018834-4ligp4ak	77	1	Mixed	mixed	JJ
cord-018834-4ligp4ak	77	2	disulfi	disulfi	NN
cord-018834-4ligp4ak	77	3	de	de	IN
cord-018834-4ligp4ak	77	4	formation	formation	NN
cord-018834-4ligp4ak	77	5	increases	increase	NNS
cord-018834-4ligp4ak	77	6	as	as	IN
cord-018834-4ligp4ak	77	7	part	part	NN
cord-018834-4ligp4ak	77	8	of	of	IN
cord-018834-4ligp4ak	77	9	the	the	DT
cord-018834-4ligp4ak	77	10	aging	age	VBG
cord-018834-4ligp4ak	77	11	process	process	NN
cord-018834-4ligp4ak	77	12	and	and	CC
cord-018834-4ligp4ak	78	1	during	during	IN
cord-018834-4ligp4ak	78	2	disease	disease	NN
cord-018834-4ligp4ak	78	3	processes	process	NNS
cord-018834-4ligp4ak	78	4	characterized	characterize	VBN
cord-018834-4ligp4ak	78	5	by	by	IN
cord-018834-4ligp4ak	78	6	oxidative	oxidative	JJ
cord-018834-4ligp4ak	78	7	stress	stress	NN
cord-018834-4ligp4ak	78	8	that	that	WDT
cord-018834-4ligp4ak	78	9	enhances	enhance	VBZ
cord-018834-4ligp4ak	78	10	endothelial	endothelial	JJ
cord-018834-4ligp4ak	78	11	cell	cell	NN
cord-018834-4ligp4ak	78	12	damage	damage	NN
cord-018834-4ligp4ak	78	13	through	through	IN
cord-018834-4ligp4ak	78	14	oxidative	oxidative	JJ
cord-018834-4ligp4ak	78	15	stress	stress	NN
cord-018834-4ligp4ak	78	16	and	and	CC
cord-018834-4ligp4ak	78	17	increase	increase	NN
cord-018834-4ligp4ak	78	18	in	in	IN
cord-018834-4ligp4ak	78	19	apoptosis	apoptosis	NN
cord-018834-4ligp4ak	78	20	levels	level	NNS
cord-018834-4ligp4ak	78	21	.	.	.
cord-018834-4ligp4ak	79	1	Cysteine	cysteine	NN
cord-018834-4ligp4ak	79	2	34	34	CD
cord-018834-4ligp4ak	79	3	(	(	-LRB-
cord-018834-4ligp4ak	79	4	Cys	Cys	NNP
cord-018834-4ligp4ak	79	5	34	34	CD
cord-018834-4ligp4ak	79	6	)	)	-RRB-
cord-018834-4ligp4ak	79	7	represents	represent	VBZ
cord-018834-4ligp4ak	79	8	the	the	DT
cord-018834-4ligp4ak	79	9	largest	large	JJS
cord-018834-4ligp4ak	79	10	fraction	fraction	NN
cord-018834-4ligp4ak	79	11	of	of	IN
cord-018834-4ligp4ak	79	12	free	free	JJ
cord-018834-4ligp4ak	79	13	thiol	thiol	NN
cord-018834-4ligp4ak	79	14	in	in	IN
cord-018834-4ligp4ak	79	15	human	human	JJ
cord-018834-4ligp4ak	79	16	plasma	plasma	NN
cord-018834-4ligp4ak	79	17	,	,	,
cord-018834-4ligp4ak	79	18	HAS	have	VBZ
cord-018834-4ligp4ak	79	19	being	be	VBG
cord-018834-4ligp4ak	79	20	the	the	DT
cord-018834-4ligp4ak	79	21	most	most	RBS
cord-018834-4ligp4ak	79	22	abundant	abundant	JJ
cord-018834-4ligp4ak	79	23	protein	protein	NN
cord-018834-4ligp4ak	79	24	in	in	IN
cord-018834-4ligp4ak	79	25	plasma	plasma	NN
cord-018834-4ligp4ak	79	26	.	.	.
cord-018834-4ligp4ak	80	1	Cys34	Cys34	NNP
cord-018834-4ligp4ak	80	2	is	be	VBZ
cord-018834-4ligp4ak	80	3	located	locate	VBN
cord-018834-4ligp4ak	80	4	at	at	IN
cord-018834-4ligp4ak	80	5	the	the	DT
cord-018834-4ligp4ak	80	6	surface	surface	NN
cord-018834-4ligp4ak	80	7	of	of	IN
cord-018834-4ligp4ak	80	8	HAS	have	VBZ
cord-018834-4ligp4ak	80	9	,	,	,
cord-018834-4ligp4ak	80	10	close	close	RB
cord-018834-4ligp4ak	80	11	to	to	IN
cord-018834-4ligp4ak	80	12	Aspartate	Aspartate	NNP
cord-018834-4ligp4ak	80	13	38	38	CD
cord-018834-4ligp4ak	80	14	(	(	-LRB-
cord-018834-4ligp4ak	80	15	Asp38	Asp38	NNP
cord-018834-4ligp4ak	80	16	)	)	-RRB-
cord-018834-4ligp4ak	80	17	,	,	,
cord-018834-4ligp4ak	80	18	Histidine	Histidine	NNP
cord-018834-4ligp4ak	80	19	39	39	CD
cord-018834-4ligp4ak	80	20	(	(	-LRB-
cord-018834-4ligp4ak	80	21	His39	His39	NNP
cord-018834-4ligp4ak	80	22	)	)	-RRB-
cord-018834-4ligp4ak	80	23	,	,	,
cord-018834-4ligp4ak	80	24	and	and	CC
cord-018834-4ligp4ak	80	25	Tyrosine	tyrosine	NN
cord-018834-4ligp4ak	80	26	84	84	CD
cord-018834-4ligp4ak	80	27	(	(	-LRB-
cord-018834-4ligp4ak	80	28	Tyr	Tyr	NNP
cord-018834-4ligp4ak	80	29	84	84	CD
cord-018834-4ligp4ak	80	30	)	)	-RRB-
cord-018834-4ligp4ak	80	31	.	.	.
cord-018834-4ligp4ak	81	1	These	these	DT
cord-018834-4ligp4ak	81	2	three	three	CD
cord-018834-4ligp4ak	81	3	residues	residue	NNS
cord-018834-4ligp4ak	81	4	affect	affect	VBP
cord-018834-4ligp4ak	81	5	the	the	DT
cord-018834-4ligp4ak	81	6	ionization	ionization	NN
cord-018834-4ligp4ak	81	7	state	state	NN
cord-018834-4ligp4ak	81	8	of	of	IN
cord-018834-4ligp4ak	81	9	Cys34	Cys34	NNP
cord-018834-4ligp4ak	81	10	,	,	,
cord-018834-4ligp4ak	81	11	thus	thus	RB
cord-018834-4ligp4ak	81	12	modulating	modulate	VBG
cord-018834-4ligp4ak	81	13	its	-PRON-	PRP$
cord-018834-4ligp4ak	81	14	reactivity	reactivity	NN
cord-018834-4ligp4ak	81	15	[	[	-LRB-
cord-018834-4ligp4ak	81	16	13	13	CD
cord-018834-4ligp4ak	81	17	]	]	-RRB-
cord-018834-4ligp4ak	81	18	.	.	.
cord-018834-4ligp4ak	82	1	In	in	IN
cord-018834-4ligp4ak	82	2	healthy	healthy	JJ
cord-018834-4ligp4ak	82	3	adults	adult	NNS
cord-018834-4ligp4ak	82	4	,	,	,
cord-018834-4ligp4ak	82	5	about	about	RB
cord-018834-4ligp4ak	82	6	70	70	CD
cord-018834-4ligp4ak	82	7	-	-	SYM
cord-018834-4ligp4ak	82	8	80	80	CD
cord-018834-4ligp4ak	82	9	%	%	NN
cord-018834-4ligp4ak	82	10	of	of	IN
cord-018834-4ligp4ak	82	11	the	the	DT
cord-018834-4ligp4ak	82	12	Cys34	Cys34	NNP
cord-018834-4ligp4ak	82	13	in	in	IN
cord-018834-4ligp4ak	82	14	albumin	albumin	NN
cord-018834-4ligp4ak	82	15	contains	contain	VBZ
cord-018834-4ligp4ak	82	16	a	a	DT
cord-018834-4ligp4ak	82	17	free	free	JJ
cord-018834-4ligp4ak	82	18	sulfhydryl	sulfhydryl	NN
cord-018834-4ligp4ak	82	19	group	group	NN
cord-018834-4ligp4ak	82	20	,	,	,
cord-018834-4ligp4ak	82	21	whereas	whereas	IN
cord-018834-4ligp4ak	82	22	about	about	RB
cord-018834-4ligp4ak	82	23	25	25	CD
cord-018834-4ligp4ak	82	24	-	-	SYM
cord-018834-4ligp4ak	82	25	30	30	CD
cord-018834-4ligp4ak	82	26	%	%	NN
cord-018834-4ligp4ak	82	27	of	of	IN
cord-018834-4ligp4ak	82	28	the	the	DT
cord-018834-4ligp4ak	82	29	HSA	HSA	NNP
cord-018834-4ligp4ak	82	30	molecules	molecule	NNS
cord-018834-4ligp4ak	82	31	have	have	VBP
cord-018834-4ligp4ak	82	32	Cys34	Cys34	NNP
cord-018834-4ligp4ak	82	33	forming	form	VBG
cord-018834-4ligp4ak	82	34	a	a	DT
cord-018834-4ligp4ak	82	35	mixed	mixed	JJ
cord-018834-4ligp4ak	82	36	disulfi	disulfi	NN
cord-018834-4ligp4ak	82	37	de	de	FW
cord-018834-4ligp4ak	82	38	with	with	IN
cord-018834-4ligp4ak	82	39	either	either	CC
cord-018834-4ligp4ak	82	40	cysteine	cysteine	NN
cord-018834-4ligp4ak	82	41	or	or	CC
cord-018834-4ligp4ak	82	42	homocysteine	homocysteine	NN
cord-018834-4ligp4ak	82	43	or	or	CC
cord-018834-4ligp4ak	82	44	glutathione	glutathione	NN
cord-018834-4ligp4ak	82	45	,	,	,
cord-018834-4ligp4ak	82	46	thus	thus	RB
cord-018834-4ligp4ak	82	47	affecting	affect	VBG
cord-018834-4ligp4ak	82	48	the	the	DT
cord-018834-4ligp4ak	82	49	Cys34	Cys34	NNP
cord-018834-4ligp4ak	82	50	redox	redox	NN
cord-018834-4ligp4ak	82	51	potential	potential	NN
cord-018834-4ligp4ak	82	52	.	.	.
cord-018834-4ligp4ak	83	1	Oxidation	oxidation	NN
cord-018834-4ligp4ak	83	2	of	of	IN
cord-018834-4ligp4ak	83	3	Cys34	Cys34	NNP
cord-018834-4ligp4ak	83	4	leads	lead	VBZ
cord-018834-4ligp4ak	83	5	to	to	IN
cord-018834-4ligp4ak	83	6	the	the	DT
cord-018834-4ligp4ak	83	7	formation	formation	NN
cord-018834-4ligp4ak	83	8	of	of	IN
cord-018834-4ligp4ak	83	9	sulfenic	sulfenic	NNP
cord-018834-4ligp4ak	83	10	acid	acid	NNP
cord-018834-4ligp4ak	83	11	(	(	-LRB-
cord-018834-4ligp4ak	83	12	RSOH	RSOH	NNP
cord-018834-4ligp4ak	83	13	)	)	-RRB-
cord-018834-4ligp4ak	83	14	,	,	,
cord-018834-4ligp4ak	83	15	which	which	WDT
cord-018834-4ligp4ak	83	16	is	be	VBZ
cord-018834-4ligp4ak	83	17	further	further	RB
cord-018834-4ligp4ak	83	18	oxidized	oxidize	VBN
cord-018834-4ligp4ak	83	19	to	to	IN
cord-018834-4ligp4ak	83	20	sulfi	sulfi	NNP
cord-018834-4ligp4ak	83	21	nic	nic	NNP
cord-018834-4ligp4ak	83	22	(	(	-LRB-
cord-018834-4ligp4ak	83	23	RSO	RSO	NNP
cord-018834-4ligp4ak	83	24	2	2	CD
cord-018834-4ligp4ak	83	25	H	H	NNP
cord-018834-4ligp4ak	83	26	)	)	-RRB-
cord-018834-4ligp4ak	83	27	or	or	CC
cord-018834-4ligp4ak	83	28	sulfonic	sulfonic	JJ
cord-018834-4ligp4ak	83	29	acid	acid	NN
cord-018834-4ligp4ak	83	30	form	form	NN
cord-018834-4ligp4ak	83	31	(	(	-LRB-
cord-018834-4ligp4ak	83	32	RSO	RSO	NNP
cord-018834-4ligp4ak	83	33	3	3	CD
cord-018834-4ligp4ak	83	34	H	H	NNP
cord-018834-4ligp4ak	83	35	)	)	-RRB-
cord-018834-4ligp4ak	83	36	.	.	.
cord-018834-4ligp4ak	84	1	Sulfenic	sulfenic	JJ
cord-018834-4ligp4ak	84	2	acid	acid	NN
cord-018834-4ligp4ak	84	3	constitutes	constitute	VBZ
cord-018834-4ligp4ak	84	4	a	a	DT
cord-018834-4ligp4ak	84	5	central	central	JJ
cord-018834-4ligp4ak	84	6	intermediate	intermediate	NN
cord-018834-4ligp4ak	84	7	in	in	IN
cord-018834-4ligp4ak	84	8	both	both	CC
cord-018834-4ligp4ak	84	9	the	the	DT
cord-018834-4ligp4ak	84	10	reversible	reversible	JJ
cord-018834-4ligp4ak	84	11	and	and	CC
cord-018834-4ligp4ak	84	12	irreversible	irreversible	JJ
cord-018834-4ligp4ak	84	13	redox	redox	JJ
cord-018834-4ligp4ak	84	14	modulation	modulation	NN
cord-018834-4ligp4ak	84	15	by	by	IN
cord-018834-4ligp4ak	84	16	reactive	reactive	JJ
cord-018834-4ligp4ak	84	17	species	specie	NNS
cord-018834-4ligp4ak	84	18	.	.	.
cord-018834-4ligp4ak	85	1	Reactive	reactive	JJ
cord-018834-4ligp4ak	85	2	nitrogen	nitrogen	NN
cord-018834-4ligp4ak	85	3	species	specie	NNS
cord-018834-4ligp4ak	85	4	(	(	-LRB-
cord-018834-4ligp4ak	85	5	RNS	RNS	NNP
cord-018834-4ligp4ak	85	6	)	)	-RRB-
cord-018834-4ligp4ak	85	7	constitute	constitute	VBP
cord-018834-4ligp4ak	85	8	nitrogen	nitrogen	NN
cord-018834-4ligp4ak	85	9	-	-	HYPH
cord-018834-4ligp4ak	85	10	centered	center	VBN
cord-018834-4ligp4ak	85	11	species	specie	NNS
cord-018834-4ligp4ak	85	12	analogous	analogous	JJ
cord-018834-4ligp4ak	85	13	to	to	IN
cord-018834-4ligp4ak	85	14	ROS	ROS	NNP
cord-018834-4ligp4ak	85	15	.	.	.
cord-018834-4ligp4ak	86	1	RNS	RNS	NNP
cord-018834-4ligp4ak	86	2	such	such	JJ
cord-018834-4ligp4ak	86	3	as	as	IN
cord-018834-4ligp4ak	86	4	nitric	nitric	JJ
cord-018834-4ligp4ak	86	5	acid	acid	NN
cord-018834-4ligp4ak	86	6	(	(	-LRB-
cord-018834-4ligp4ak	86	7	NO	no	UH
cord-018834-4ligp4ak	86	8	)	)	-RRB-
cord-018834-4ligp4ak	86	9	contribute	contribute	VB
cord-018834-4ligp4ak	86	10	to	to	IN
cord-018834-4ligp4ak	86	11	various	various	JJ
cord-018834-4ligp4ak	86	12	biological	biological	JJ
cord-018834-4ligp4ak	86	13	processes	process	NNS
cord-018834-4ligp4ak	86	14	.	.	.
cord-018834-4ligp4ak	87	1	HSA	HSA	NNP
cord-018834-4ligp4ak	87	2	acts	act	VBZ
cord-018834-4ligp4ak	87	3	as	as	IN
cord-018834-4ligp4ak	87	4	a	a	DT
cord-018834-4ligp4ak	87	5	NO	NO	NNP
cord-018834-4ligp4ak	87	6	depot	depot	NN
cord-018834-4ligp4ak	87	7	and	and	CC
cord-018834-4ligp4ak	87	8	a	a	DT
cord-018834-4ligp4ak	87	9	NO	no	DT
cord-018834-4ligp4ak	87	10	transducer	transducer	NN
cord-018834-4ligp4ak	87	11	.	.	.
cord-018834-4ligp4ak	88	1	Moreover	moreover	RB
cord-018834-4ligp4ak	88	2	,	,	,
cord-018834-4ligp4ak	88	3	82	82	CD
cord-018834-4ligp4ak	88	4	%	%	NN
cord-018834-4ligp4ak	88	5	of	of	IN
cord-018834-4ligp4ak	88	6	NO	no	DT
cord-018834-4ligp4ak	88	7	in	in	IN
cord-018834-4ligp4ak	88	8	blood	blood	NN
cord-018834-4ligp4ak	88	9	(	(	-LRB-
cord-018834-4ligp4ak	88	10	~7	~7	NFP
cord-018834-4ligp4ak	88	11	μ[mu	μ[mu	XX
cord-018834-4ligp4ak	88	12	]	]	-RRB-
cord-018834-4ligp4ak	88	13	M	M	NNP
cord-018834-4ligp4ak	88	14	)	)	-RRB-
cord-018834-4ligp4ak	88	15	is	be	VBZ
cord-018834-4ligp4ak	88	16	transported	transport	VBN
cord-018834-4ligp4ak	88	17	as	as	IN
cord-018834-4ligp4ak	88	18	an	an	DT
cord-018834-4ligp4ak	88	19	S	S	NNP
cord-018834-4ligp4ak	88	20	-	-	HYPH
cord-018834-4ligp4ak	88	21	nitrosothiol	nitrosothiol	NN
cord-018834-4ligp4ak	88	22	bound	bind	VBN
cord-018834-4ligp4ak	88	23	at	at	IN
cord-018834-4ligp4ak	88	24	the	the	DT
cord-018834-4ligp4ak	88	25	HSA	HSA	NNP
cord-018834-4ligp4ak	88	26	residue	residue	NN
cord-018834-4ligp4ak	88	27	Cys34	Cys34	NNP
cord-018834-4ligp4ak	88	28	.	.	.
cord-018834-4ligp4ak	89	1	S	s	NN
cord-018834-4ligp4ak	89	2	-	-	HYPH
cord-018834-4ligp4ak	89	3	nitrosylated	nitrosylate	VBN
cord-018834-4ligp4ak	89	4	HSA	HSA	NNP
cord-018834-4ligp4ak	89	5	may	may	MD
cord-018834-4ligp4ak	89	6	represent	represent	VB
cord-018834-4ligp4ak	89	7	a	a	DT
cord-018834-4ligp4ak	89	8	circulating	circulate	VBG
cord-018834-4ligp4ak	89	9	endogenous	endogenous	JJ
cord-018834-4ligp4ak	89	10	reservoir	reservoir	NN
cord-018834-4ligp4ak	89	11	of	of	IN
cord-018834-4ligp4ak	89	12	NO	no	NN
cord-018834-4ligp4ak	89	13	and	and	CC
cord-018834-4ligp4ak	89	14	may	may	MD
cord-018834-4ligp4ak	89	15	act	act	VB
cord-018834-4ligp4ak	89	16	as	as	IN
cord-018834-4ligp4ak	89	17	an	an	DT
cord-018834-4ligp4ak	89	18	NO	no	DT
cord-018834-4ligp4ak	89	19	donor	donor	NN
cord-018834-4ligp4ak	89	20	.	.	.
cord-018834-4ligp4ak	90	1	S	s	NN
cord-018834-4ligp4ak	90	2	-	-	HYPH
cord-018834-4ligp4ak	90	3	nitrosylated	nitrosylate	VBN
cord-018834-4ligp4ak	90	4	HSA	HSA	NNP
cord-018834-4ligp4ak	90	5	acts	act	VBZ
cord-018834-4ligp4ak	90	6	primarily	primarily	RB
cord-018834-4ligp4ak	90	7	as	as	IN
cord-018834-4ligp4ak	90	8	a	a	DT
cord-018834-4ligp4ak	90	9	vasodilator	vasodilator	NN
cord-018834-4ligp4ak	90	10	in	in	IN
cord-018834-4ligp4ak	90	11	vivo	vivo	NN
cord-018834-4ligp4ak	90	12	and	and	CC
cord-018834-4ligp4ak	90	13	represents	represent	VBZ
cord-018834-4ligp4ak	90	14	a	a	DT
cord-018834-4ligp4ak	90	15	stable	stable	JJ
cord-018834-4ligp4ak	90	16	reservoir	reservoir	NN
cord-018834-4ligp4ak	90	17	of	of	IN
cord-018834-4ligp4ak	90	18	NO	no	DT
cord-018834-4ligp4ak	90	19	that	that	WDT
cord-018834-4ligp4ak	90	20	can	can	MD
cord-018834-4ligp4ak	90	21	be	be	VB
cord-018834-4ligp4ak	90	22	released	release	VBN
cord-018834-4ligp4ak	90	23	when	when	WRB
cord-018834-4ligp4ak	90	24	the	the	DT
cord-018834-4ligp4ak	90	25	concentrations	concentration	NNS
cord-018834-4ligp4ak	90	26	of	of	IN
cord-018834-4ligp4ak	90	27	lowmolecular	lowmolecular	JJ
cord-018834-4ligp4ak	90	28	-	-	HYPH
cord-018834-4ligp4ak	90	29	weight	weight	NN
cord-018834-4ligp4ak	90	30	thiols	thiol	NNS
cord-018834-4ligp4ak	90	31	are	be	VBP
cord-018834-4ligp4ak	90	32	elevated	elevate	VBN
cord-018834-4ligp4ak	90	33	[	[	-LRB-
cord-018834-4ligp4ak	90	34	19	19	CD
cord-018834-4ligp4ak	90	35	]	]	-RRB-
cord-018834-4ligp4ak	90	36	.	.	.
cord-018834-4ligp4ak	91	1	S	s	NN
cord-018834-4ligp4ak	91	2	-	-	HYPH
cord-018834-4ligp4ak	91	3	nitrosylated	nitrosylate	VBN
cord-018834-4ligp4ak	91	4	HSA	HSA	NNP
cord-018834-4ligp4ak	91	5	has	have	VBZ
cord-018834-4ligp4ak	91	6	been	be	VBN
cord-018834-4ligp4ak	91	7	shown	show	VBN
cord-018834-4ligp4ak	91	8	to	to	TO
cord-018834-4ligp4ak	91	9	reduce	reduce	VB
cord-018834-4ligp4ak	91	10	either	either	CC
cord-018834-4ligp4ak	91	11	ischemia	ischemia	NN
cord-018834-4ligp4ak	91	12	or	or	CC
cord-018834-4ligp4ak	91	13	reperfusion	reperfusion	NN
cord-018834-4ligp4ak	91	14	injury	injury	NN
cord-018834-4ligp4ak	91	15	in	in	IN
cord-018834-4ligp4ak	91	16	pig	pig	NN
cord-018834-4ligp4ak	91	17	and	and	CC
cord-018834-4ligp4ak	91	18	rabbit	rabbit	NN
cord-018834-4ligp4ak	91	19	hearts	heart	NNS
cord-018834-4ligp4ak	91	20	after	after	IN
cord-018834-4ligp4ak	91	21	unprotected	unprotected	JJ
cord-018834-4ligp4ak	91	22	warm	warm	JJ
cord-018834-4ligp4ak	91	23	ischemia	ischemia	NN
cord-018834-4ligp4ak	91	24	through	through	IN
cord-018834-4ligp4ak	91	25	long	long	RB
cord-018834-4ligp4ak	91	26	-	-	HYPH
cord-018834-4ligp4ak	91	27	lasting	last	VBG
cord-018834-4ligp4ak	91	28	release	release	NN
cord-018834-4ligp4ak	91	29	of	of	IN
cord-018834-4ligp4ak	91	30	NO	no	DT
cord-018834-4ligp4ak	91	31	[	[	-LRB-
cord-018834-4ligp4ak	91	32	13	13	CD
cord-018834-4ligp4ak	91	33	]	]	-RRB-
cord-018834-4ligp4ak	91	34	.	.	.
cord-018834-4ligp4ak	92	1	Other	other	JJ
cord-018834-4ligp4ak	92	2	RNS	RNS	NNP
cord-018834-4ligp4ak	92	3	,	,	,
cord-018834-4ligp4ak	92	4	such	such	JJ
cord-018834-4ligp4ak	92	5	as	as	IN
cord-018834-4ligp4ak	92	6	peroxynitrite	peroxynitrite	NN
cord-018834-4ligp4ak	92	7	(	(	-LRB-
cord-018834-4ligp4ak	92	8	ONOO	ONOO	NNP
cord-018834-4ligp4ak	92	9	−	−	NNP
cord-018834-4ligp4ak	92	10	)	)	-RRB-
cord-018834-4ligp4ak	92	11	,	,	,
cord-018834-4ligp4ak	92	12	constitute	constitute	VBP
cord-018834-4ligp4ak	92	13	powerful	powerful	JJ
cord-018834-4ligp4ak	92	14	oxidants	oxidant	NNS
cord-018834-4ligp4ak	92	15	and	and	CC
cord-018834-4ligp4ak	92	16	nitrating	nitrating	NN
cord-018834-4ligp4ak	92	17	species	specie	NNS
cord-018834-4ligp4ak	92	18	[	[	-LRB-
cord-018834-4ligp4ak	92	19	20	20	CD
cord-018834-4ligp4ak	92	20	]	]	-RRB-
cord-018834-4ligp4ak	92	21	.	.	.
cord-018834-4ligp4ak	93	1	The	the	DT
cord-018834-4ligp4ak	93	2	-SH	-SH	NNS
cord-018834-4ligp4ak	93	3	group	group	NN
cord-018834-4ligp4ak	93	4	of	of	IN
cord-018834-4ligp4ak	93	5	albumin	albumin	NN
cord-018834-4ligp4ak	93	6	represents	represent	VBZ
cord-018834-4ligp4ak	93	7	an	an	DT
cord-018834-4ligp4ak	93	8	important	important	JJ
cord-018834-4ligp4ak	93	9	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	93	10	against	against	IN
cord-018834-4ligp4ak	93	11	peroxynitrite	peroxynitrite	NN
cord-018834-4ligp4ak	93	12	as	as	IN
cord-018834-4ligp4ak	93	13	the	the	DT
cord-018834-4ligp4ak	93	14	thiol	thiol	NN
cord-018834-4ligp4ak	93	15	group	group	NN
cord-018834-4ligp4ak	93	16	was	be	VBD
cord-018834-4ligp4ak	93	17	oxidized	oxidize	VBN
cord-018834-4ligp4ak	93	18	to	to	IN
cord-018834-4ligp4ak	93	19	a	a	DT
cord-018834-4ligp4ak	93	20	sulfenic	sulfenic	JJ
cord-018834-4ligp4ak	93	21	acid	acid	NN
cord-018834-4ligp4ak	93	22	(	(	-LRB-
cord-018834-4ligp4ak	93	23	HSA	HSA	NNP
cord-018834-4ligp4ak	93	24	-	-	HYPH
cord-018834-4ligp4ak	93	25	SOH	SOH	NNP
cord-018834-4ligp4ak	93	26	)	)	-RRB-
cord-018834-4ligp4ak	93	27	.	.	.
cord-018834-4ligp4ak	94	1	Subsequently	subsequently	RB
cord-018834-4ligp4ak	94	2	,	,	,
cord-018834-4ligp4ak	94	3	HSA	HSA	NNP
cord-018834-4ligp4ak	94	4	-	-	HYPH
cord-018834-4ligp4ak	94	5	SOH	SOH	NNP
cord-018834-4ligp4ak	94	6	can	can	MD
cord-018834-4ligp4ak	94	7	be	be	VB
cord-018834-4ligp4ak	94	8	converted	convert	VBN
cord-018834-4ligp4ak	94	9	to	to	IN
cord-018834-4ligp4ak	94	10	a	a	DT
cord-018834-4ligp4ak	94	11	disulfi	disulfi	NN
cord-018834-4ligp4ak	94	12	de	de	NN
cord-018834-4ligp4ak	94	13	and	and	CC
cord-018834-4ligp4ak	94	14	then	then	RB
cord-018834-4ligp4ak	94	15	back	back	RB
cord-018834-4ligp4ak	94	16	to	to	IN
cord-018834-4ligp4ak	94	17	mercapto	mercapto	JJ
cord-018834-4ligp4ak	94	18	-	-	HYPH
cord-018834-4ligp4ak	94	19	albumin	albumin	NN
cord-018834-4ligp4ak	94	20	(	(	-LRB-
cord-018834-4ligp4ak	94	21	HSA	HSA	NNP
cord-018834-4ligp4ak	94	22	-	-	HYPH
cord-018834-4ligp4ak	94	23	SH	SH	NNP
cord-018834-4ligp4ak	94	24	)	)	-RRB-
cord-018834-4ligp4ak	94	25	.	.	.
cord-018834-4ligp4ak	95	1	HSA	HSA	NNP
cord-018834-4ligp4ak	95	2	administration	administration	NN
cord-018834-4ligp4ak	95	3	favorably	favorably	RB
cord-018834-4ligp4ak	95	4	infl	infl	NNP
cord-018834-4ligp4ak	95	5	uences	uences	NNP
cord-018834-4ligp4ak	95	6	plasma	plasma	NN
cord-018834-4ligp4ak	95	7	thiol	thiol	NN
cord-018834-4ligp4ak	95	8	-	-	HYPH
cord-018834-4ligp4ak	95	9	dependent	dependent	JJ
cord-018834-4ligp4ak	95	10	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	95	11	status	status	NN
cord-018834-4ligp4ak	95	12	,	,	,
cord-018834-4ligp4ak	95	13	as	as	RB
cord-018834-4ligp4ak	95	14	well	well	RB
cord-018834-4ligp4ak	95	15	as	as	IN
cord-018834-4ligp4ak	95	16	levels	level	NNS
cord-018834-4ligp4ak	95	17	of	of	IN
cord-018834-4ligp4ak	95	18	protein	protein	NN
cord-018834-4ligp4ak	95	19	oxidative	oxidative	JJ
cord-018834-4ligp4ak	95	20	damage	damage	NN
cord-018834-4ligp4ak	95	21	in	in	IN
cord-018834-4ligp4ak	95	22	patients	patient	NNS
cord-018834-4ligp4ak	95	23	with	with	IN
cord-018834-4ligp4ak	95	24	sepsis	sepsis	NN
cord-018834-4ligp4ak	95	25	and	and	CC
cord-018834-4ligp4ak	95	26	acute	acute	JJ
cord-018834-4ligp4ak	95	27	respiratory	respiratory	JJ
cord-018834-4ligp4ak	95	28	distress	distress	NN
cord-018834-4ligp4ak	95	29	syndrome	syndrome	NN
cord-018834-4ligp4ak	95	30	(	(	-LRB-
cord-018834-4ligp4ak	95	31	ARDS	ARDS	NNP
cord-018834-4ligp4ak	95	32	)	)	-RRB-
cord-018834-4ligp4ak	96	1	[	[	-LRB-
cord-018834-4ligp4ak	96	2	21	21	CD
cord-018834-4ligp4ak	96	3	,	,	,
cord-018834-4ligp4ak	96	4	22	22	CD
cord-018834-4ligp4ak	96	5	]	]	-RRB-
cord-018834-4ligp4ak	96	6	.	.	.
cord-018834-4ligp4ak	97	1	Moreover	moreover	RB
cord-018834-4ligp4ak	97	2	,	,	,
cord-018834-4ligp4ak	97	3	HSA	HSA	NNP
cord-018834-4ligp4ak	97	4	is	be	VBZ
cord-018834-4ligp4ak	97	5	able	able	JJ
cord-018834-4ligp4ak	97	6	to	to	TO
cord-018834-4ligp4ak	97	7	scavenge	scavenge	VB
cord-018834-4ligp4ak	97	8	strongly	strongly	RB
cord-018834-4ligp4ak	97	9	oxidant	oxidant	JJ
cord-018834-4ligp4ak	97	10	compounds	compound	NNS
cord-018834-4ligp4ak	97	11	such	such	JJ
cord-018834-4ligp4ak	97	12	as	as	IN
cord-018834-4ligp4ak	97	13	hypochlorous	hypochlorous	JJ
cord-018834-4ligp4ak	97	14	acid	acid	NN
cord-018834-4ligp4ak	97	15	(	(	-LRB-
cord-018834-4ligp4ak	97	16	HOCI	HOCI	NNP
cord-018834-4ligp4ak	97	17	)	)	-RRB-
cord-018834-4ligp4ak	97	18	and	and	CC
cord-018834-4ligp4ak	97	19	hypothiocyanous	hypothiocyanous	JJ
cord-018834-4ligp4ak	97	20	acid	acid	NN
cord-018834-4ligp4ak	97	21	.	.	.
cord-018834-4ligp4ak	98	1	Cys34	Cys34	NNP
cord-018834-4ligp4ak	98	2	is	be	VBZ
cord-018834-4ligp4ak	98	3	oxidized	oxidize	VBN
cord-018834-4ligp4ak	98	4	preferentially	preferentially	RB
cord-018834-4ligp4ak	98	5	by	by	IN
cord-018834-4ligp4ak	98	6	hypochlorous	hypochlorous	JJ
cord-018834-4ligp4ak	98	7	and	and	CC
cord-018834-4ligp4ak	98	8	hypothiocyanous	hypothiocyanous	JJ
cord-018834-4ligp4ak	98	9	acid	acid	NN
cord-018834-4ligp4ak	98	10	with	with	IN
cord-018834-4ligp4ak	98	11	the	the	DT
cord-018834-4ligp4ak	98	12	corresponding	corresponding	JJ
cord-018834-4ligp4ak	98	13	sulfenyl	sulfenyl	NN
cord-018834-4ligp4ak	98	14	derivative	derivative	JJ
cord-018834-4ligp4ak	98	15	.	.	.
cord-018834-4ligp4ak	99	1	HSA	HSA	NNP
cord-018834-4ligp4ak	99	2	is	be	VBZ
cord-018834-4ligp4ak	99	3	able	able	JJ
cord-018834-4ligp4ak	99	4	to	to	TO
cord-018834-4ligp4ak	99	5	scavenge	scavenge	VB
cord-018834-4ligp4ak	99	6	HOCI	HOCI	NNP
cord-018834-4ligp4ak	99	7	,	,	,
cord-018834-4ligp4ak	99	8	preventing	prevent	VBG
cord-018834-4ligp4ak	99	9	alteration	alteration	NN
cord-018834-4ligp4ak	99	10	of	of	IN
cord-018834-4ligp4ak	99	11	its	-PRON-	PRP$
cord-018834-4ligp4ak	99	12	preferential	preferential	JJ
cord-018834-4ligp4ak	99	13	biological	biological	JJ
cord-018834-4ligp4ak	99	14	target	target	NN
cord-018834-4ligp4ak	99	15	α(alpha	α(alpha	''
cord-018834-4ligp4ak	99	16	)	)	-RRB-
cord-018834-4ligp4ak	99	17	1	1	CD
cord-018834-4ligp4ak	99	18	-antiprotease	-antiprotease	CD
cord-018834-4ligp4ak	99	19	[	[	-LRB-
cord-018834-4ligp4ak	99	20	23	23	CD
cord-018834-4ligp4ak	99	21	]	]	-RRB-
cord-018834-4ligp4ak	99	22	.	.	.
cord-018834-4ligp4ak	100	1	Interestingly	interestingly	RB
cord-018834-4ligp4ak	100	2	,	,	,
cord-018834-4ligp4ak	100	3	West	West	NNP
cord-018834-4ligp4ak	100	4	Nile	Nile	NNP
cord-018834-4ligp4ak	100	5	virus	virus	NN
cord-018834-4ligp4ak	100	6	is	be	VBZ
cord-018834-4ligp4ak	100	7	neutralized	neutralize	VBN
cord-018834-4ligp4ak	100	8	by	by	IN
cord-018834-4ligp4ak	100	9	hypochlorous	hypochlorous	JJ
cord-018834-4ligp4ak	100	10	acid	acid	NN
cord-018834-4ligp4ak	100	11	-	-	HYPH
cord-018834-4ligp4ak	100	12	modifi	modifi	NN
cord-018834-4ligp4ak	100	13	ed	ed	NN
cord-018834-4ligp4ak	100	14	HSA	HSA	NNP
cord-018834-4ligp4ak	100	15	that	that	WDT
cord-018834-4ligp4ak	100	16	binds	bind	VBZ
cord-018834-4ligp4ak	100	17	to	to	IN
cord-018834-4ligp4ak	100	18	domain	domain	NN
cord-018834-4ligp4ak	100	19	III	iii	CD
cord-018834-4ligp4ak	100	20	of	of	IN
cord-018834-4ligp4ak	100	21	the	the	DT
cord-018834-4ligp4ak	100	22	viral	viral	JJ
cord-018834-4ligp4ak	100	23	envelope	envelope	NN
cord-018834-4ligp4ak	100	24	protein	protein	NN
cord-018834-4ligp4ak	100	25	E	e	NN
cord-018834-4ligp4ak	100	26	[	[	-LRB-
cord-018834-4ligp4ak	100	27	24	24	CD
cord-018834-4ligp4ak	100	28	]	]	-RRB-
cord-018834-4ligp4ak	100	29	.	.	.
cord-018834-4ligp4ak	101	1	During	during	IN
cord-018834-4ligp4ak	101	2	its	-PRON-	PRP$
cord-018834-4ligp4ak	101	3	long	long	JJ
cord-018834-4ligp4ak	101	4	life	life	NN
cord-018834-4ligp4ak	101	5	(	(	-LRB-
cord-018834-4ligp4ak	101	6	~3	~3	CD
cord-018834-4ligp4ak	101	7	weeks	week	NNS
cord-018834-4ligp4ak	101	8	)	)	-RRB-
cord-018834-4ligp4ak	101	9	,	,	,
cord-018834-4ligp4ak	101	10	an	an	DT
cord-018834-4ligp4ak	101	11	HSA	HSA	NNP
cord-018834-4ligp4ak	101	12	molecule	molecule	NN
cord-018834-4ligp4ak	101	13	makes	make	VBZ
cord-018834-4ligp4ak	101	14	15,000	15,000	CD
cord-018834-4ligp4ak	101	15	passes	pass	NNS
cord-018834-4ligp4ak	101	16	through	through	IN
cord-018834-4ligp4ak	101	17	the	the	DT
cord-018834-4ligp4ak	101	18	circulation	circulation	NN
cord-018834-4ligp4ak	101	19	,	,	,
cord-018834-4ligp4ak	101	20	incurring	incur	VBG
cord-018834-4ligp4ak	101	21	some	some	DT
cord-018834-4ligp4ak	101	22	damages	damage	NNS
cord-018834-4ligp4ak	101	23	that	that	WDT
cord-018834-4ligp4ak	101	24	affect	affect	VBP
cord-018834-4ligp4ak	101	25	its	-PRON-	PRP$
cord-018834-4ligp4ak	101	26	ligand	ligand	NN
cord-018834-4ligp4ak	101	27	-	-	HYPH
cord-018834-4ligp4ak	101	28	binding	bind	VBG
cord-018834-4ligp4ak	101	29	and	and	CC
cord-018834-4ligp4ak	101	30	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	101	31	properties	property	NNS
cord-018834-4ligp4ak	101	32	.	.	.
cord-018834-4ligp4ak	102	1	Diabetes	diabetes	NN
cord-018834-4ligp4ak	102	2	mellitus	mellitus	NN
cord-018834-4ligp4ak	102	3	is	be	VBZ
cord-018834-4ligp4ak	102	4	one	one	CD
cord-018834-4ligp4ak	102	5	of	of	IN
cord-018834-4ligp4ak	102	6	the	the	DT
cord-018834-4ligp4ak	102	7	main	main	JJ
cord-018834-4ligp4ak	102	8	pathological	pathological	JJ
cord-018834-4ligp4ak	102	9	conditions	condition	NNS
cord-018834-4ligp4ak	102	10	that	that	WDT
cord-018834-4ligp4ak	102	11	impairs	impair	VBZ
cord-018834-4ligp4ak	102	12	the	the	DT
cord-018834-4ligp4ak	102	13	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	102	14	functions	function	NNS
cord-018834-4ligp4ak	102	15	of	of	IN
cord-018834-4ligp4ak	102	16	albumin	albumin	NN
cord-018834-4ligp4ak	102	17	.	.	.
cord-018834-4ligp4ak	103	1	In	in	IN
cord-018834-4ligp4ak	103	2	this	this	DT
cord-018834-4ligp4ak	103	3	disease	disease	NN
cord-018834-4ligp4ak	103	4	,	,	,
cord-018834-4ligp4ak	103	5	albumin	albumin	NN
cord-018834-4ligp4ak	103	6	undergoes	undergo	VBZ
cord-018834-4ligp4ak	103	7	increased	increase	VBN
cord-018834-4ligp4ak	103	8	glycation	glycation	NN
cord-018834-4ligp4ak	103	9	.	.	.
cord-018834-4ligp4ak	104	1	The	the	DT
cord-018834-4ligp4ak	104	2	level	level	NN
cord-018834-4ligp4ak	104	3	of	of	IN
cord-018834-4ligp4ak	104	4	glycated	glycated	JJ
cord-018834-4ligp4ak	104	5	HSA	HSA	NNP
cord-018834-4ligp4ak	104	6	in	in	IN
cord-018834-4ligp4ak	104	7	normal	normal	JJ
cord-018834-4ligp4ak	104	8	humans	human	NNS
cord-018834-4ligp4ak	104	9	is	be	VBZ
cord-018834-4ligp4ak	104	10	about	about	RB
cord-018834-4ligp4ak	104	11	10	10	CD
cord-018834-4ligp4ak	104	12	%	%	NN
cord-018834-4ligp4ak	104	13	,	,	,
cord-018834-4ligp4ak	104	14	and	and	CC
cord-018834-4ligp4ak	104	15	increased	increase	VBD
cord-018834-4ligp4ak	104	16	to	to	IN
cord-018834-4ligp4ak	104	17	20	20	CD
cord-018834-4ligp4ak	104	18	-	-	SYM
cord-018834-4ligp4ak	104	19	30	30	CD
cord-018834-4ligp4ak	104	20	%	%	NN
cord-018834-4ligp4ak	104	21	in	in	IN
cord-018834-4ligp4ak	104	22	hyperglycemic	hyperglycemic	JJ
cord-018834-4ligp4ak	104	23	patients	patient	NNS
cord-018834-4ligp4ak	104	24	.	.	.
cord-018834-4ligp4ak	105	1	Glycation	glycation	NN
cord-018834-4ligp4ak	105	2	corresponds	correspond	VBZ
cord-018834-4ligp4ak	105	3	to	to	IN
cord-018834-4ligp4ak	105	4	the	the	DT
cord-018834-4ligp4ak	105	5	nonenzymatic	nonenzymatic	JJ
cord-018834-4ligp4ak	105	6	attachment	attachment	NN
cord-018834-4ligp4ak	105	7	of	of	IN
cord-018834-4ligp4ak	105	8	glucose	glucose	NN
cord-018834-4ligp4ak	105	9	molecule	molecule	NN
cord-018834-4ligp4ak	105	10	to	to	IN
cord-018834-4ligp4ak	105	11	a	a	DT
cord-018834-4ligp4ak	105	12	free	free	JJ
cord-018834-4ligp4ak	105	13	amine	amine	NN
cord-018834-4ligp4ak	105	14	residue	residue	NN
cord-018834-4ligp4ak	105	15	.	.	.
cord-018834-4ligp4ak	106	1	HSA	HSA	NNP
cord-018834-4ligp4ak	106	2	glycation	glycation	NN
cord-018834-4ligp4ak	106	3	is	be	VBZ
cord-018834-4ligp4ak	106	4	associated	associate	VBN
cord-018834-4ligp4ak	106	5	with	with	IN
cord-018834-4ligp4ak	106	6	oxidation	oxidation	NN
cord-018834-4ligp4ak	106	7	of	of	IN
cord-018834-4ligp4ak	106	8	His	-PRON-	PRP$
cord-018834-4ligp4ak	106	9	and	and	CC
cord-018834-4ligp4ak	106	10	Trp	trp	NN
cord-018834-4ligp4ak	106	11	residues	residue	NNS
cord-018834-4ligp4ak	106	12	,	,	,
cord-018834-4ligp4ak	106	13	main	main	JJ
cord-018834-4ligp4ak	106	14	chain	chain	NN
cord-018834-4ligp4ak	106	15	fragmentation	fragmentation	NN
cord-018834-4ligp4ak	106	16	,	,	,
cord-018834-4ligp4ak	106	17	and	and	CC
cord-018834-4ligp4ak	106	18	loss	loss	NN
cord-018834-4ligp4ak	106	19	of	of	IN
cord-018834-4ligp4ak	106	20	both	both	DT
cord-018834-4ligp4ak	106	21	secondary	secondary	JJ
cord-018834-4ligp4ak	106	22	and	and	CC
cord-018834-4ligp4ak	106	23	tertiary	tertiary	JJ
cord-018834-4ligp4ak	106	24	structure	structure	NN
cord-018834-4ligp4ak	106	25	.	.	.
cord-018834-4ligp4ak	107	1	Both	both	DT
cord-018834-4ligp4ak	107	2	the	the	DT
cord-018834-4ligp4ak	107	3	use	use	NN
cord-018834-4ligp4ak	107	4	of	of	IN
cord-018834-4ligp4ak	107	5	diclofenac	diclofenac	NNP
cord-018834-4ligp4ak	107	6	,	,	,
cord-018834-4ligp4ak	107	7	a	a	DT
cord-018834-4ligp4ak	107	8	nonsteroidal	nonsteroidal	JJ
cord-018834-4ligp4ak	107	9	anti	anti	JJ
cord-018834-4ligp4ak	107	10	-	-	JJ
cord-018834-4ligp4ak	107	11	infl	infl	JJ
cord-018834-4ligp4ak	107	12	ammatory	ammatory	NNP
cord-018834-4ligp4ak	107	13	drug	drug	NNP
cord-018834-4ligp4ak	107	14	(	(	-LRB-
cord-018834-4ligp4ak	107	15	NSAID	NSAID	NNP
cord-018834-4ligp4ak	107	16	)	)	-RRB-
cord-018834-4ligp4ak	107	17	and	and	CC
cord-018834-4ligp4ak	107	18	aspirin	aspirin	NN
cord-018834-4ligp4ak	107	19	reduces	reduce	VBZ
cord-018834-4ligp4ak	107	20	the	the	DT
cord-018834-4ligp4ak	107	21	levels	level	NNS
cord-018834-4ligp4ak	107	22	of	of	IN
cord-018834-4ligp4ak	107	23	advanced	advanced	JJ
cord-018834-4ligp4ak	107	24	glycation	glycation	NN
cord-018834-4ligp4ak	107	25	[	[	-LRB-
cord-018834-4ligp4ak	107	26	25	25	CD
cord-018834-4ligp4ak	107	27	]	]	-RRB-
cord-018834-4ligp4ak	107	28	.	.	.
cord-018834-4ligp4ak	108	1	The	the	DT
cord-018834-4ligp4ak	108	2	glycation	glycation	NN
cord-018834-4ligp4ak	108	3	of	of	IN
cord-018834-4ligp4ak	108	4	HSA	HSA	NNP
cord-018834-4ligp4ak	108	5	impairs	impair	VBZ
cord-018834-4ligp4ak	108	6	its	-PRON-	PRP$
cord-018834-4ligp4ak	108	7	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	108	8	activity	activity	NN
cord-018834-4ligp4ak	108	9	and	and	CC
cord-018834-4ligp4ak	108	10	its	-PRON-	PRP$
cord-018834-4ligp4ak	108	11	copper	copper	NN
cord-018834-4ligp4ak	108	12	-	-	HYPH
cord-018834-4ligp4ak	108	13	binding	bind	VBG
cord-018834-4ligp4ak	108	14	ability	ability	NN
cord-018834-4ligp4ak	108	15	.	.	.
cord-018834-4ligp4ak	109	1	Glycation	Glycation	NNP
cord-018834-4ligp4ak	109	2	of	of	IN
cord-018834-4ligp4ak	109	3	HSA	HSA	NNP
cord-018834-4ligp4ak	109	4	induced	induce	VBD
cord-018834-4ligp4ak	109	5	a	a	DT
cord-018834-4ligp4ak	109	6	marked	marked	JJ
cord-018834-4ligp4ak	109	7	loss	loss	NN
cord-018834-4ligp4ak	109	8	of	of	IN
cord-018834-4ligp4ak	109	9	its	-PRON-	PRP$
cord-018834-4ligp4ak	109	10	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	109	11	activity	activity	NN
cord-018834-4ligp4ak	109	12	to	to	IN
cord-018834-4ligp4ak	109	13	copper	copper	NN
cord-018834-4ligp4ak	109	14	-	-	HYPH
cord-018834-4ligp4ak	109	15	mediated	mediate	VBN
cord-018834-4ligp4ak	109	16	oxidation	oxidation	NN
cord-018834-4ligp4ak	109	17	of	of	IN
cord-018834-4ligp4ak	109	18	LDL	ldl	NN
cord-018834-4ligp4ak	109	19	,	,	,
cord-018834-4ligp4ak	109	20	probably	probably	RB
cord-018834-4ligp4ak	109	21	by	by	IN
cord-018834-4ligp4ak	109	22	the	the	DT
cord-018834-4ligp4ak	109	23	generation	generation	NN
cord-018834-4ligp4ak	109	24	of	of	IN
cord-018834-4ligp4ak	109	25	superoxide	superoxide	NN
cord-018834-4ligp4ak	109	26	.	.	.
cord-018834-4ligp4ak	110	1	Moreover	moreover	RB
cord-018834-4ligp4ak	110	2	,	,	,
cord-018834-4ligp4ak	110	3	the	the	DT
cord-018834-4ligp4ak	110	4	Fe(III)-binding	fe(iii)-binde	VBG
cord-018834-4ligp4ak	110	5	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	110	6	capacity	capacity	NN
cord-018834-4ligp4ak	110	7	of	of	IN
cord-018834-4ligp4ak	110	8	HSA	HSA	NNP
cord-018834-4ligp4ak	110	9	is	be	VBZ
cord-018834-4ligp4ak	110	10	markedly	markedly	RB
cord-018834-4ligp4ak	110	11	reduced	reduce	VBN
cord-018834-4ligp4ak	110	12	in	in	IN
cord-018834-4ligp4ak	110	13	diabetic	diabetic	JJ
cord-018834-4ligp4ak	110	14	patients	patient	NNS
cord-018834-4ligp4ak	110	15	.	.	.
cord-018834-4ligp4ak	111	1	Finally	finally	RB
cord-018834-4ligp4ak	111	2	,	,	,
cord-018834-4ligp4ak	111	3	the	the	DT
cord-018834-4ligp4ak	111	4	HSA	HSA	NNP
cord-018834-4ligp4ak	111	5	transport	transport	NN
cord-018834-4ligp4ak	111	6	of	of	IN
cord-018834-4ligp4ak	111	7	tryptophan	tryptophan	NN
cord-018834-4ligp4ak	111	8	(	(	-LRB-
cord-018834-4ligp4ak	111	9	Trp	Trp	NNP
cord-018834-4ligp4ak	111	10	)	)	-RRB-
cord-018834-4ligp4ak	111	11	,	,	,
cord-018834-4ligp4ak	111	12	which	which	WDT
cord-018834-4ligp4ak	111	13	is	be	VBZ
cord-018834-4ligp4ak	111	14	the	the	DT
cord-018834-4ligp4ak	111	15	largest	large	JJS
cord-018834-4ligp4ak	111	16	and	and	CC
cord-018834-4ligp4ak	111	17	essential	essential	JJ
cord-018834-4ligp4ak	111	18	amino	amino	NN
cord-018834-4ligp4ak	111	19	acid	acid	NN
cord-018834-4ligp4ak	111	20	,	,	,
cord-018834-4ligp4ak	111	21	is	be	VBZ
cord-018834-4ligp4ak	111	22	reduced	reduce	VBN
cord-018834-4ligp4ak	111	23	after	after	IN
cord-018834-4ligp4ak	111	24	its	-PRON-	PRP$
cord-018834-4ligp4ak	111	25	glycation	glycation	NN
cord-018834-4ligp4ak	111	26	.	.	.
cord-018834-4ligp4ak	112	1	HSA	HSA	NNP
cord-018834-4ligp4ak	112	2	glycation	glycation	NN
cord-018834-4ligp4ak	112	3	alters	alter	VBZ
cord-018834-4ligp4ak	112	4	the	the	DT
cord-018834-4ligp4ak	112	5	binding	binding	NN
cord-018834-4ligp4ak	112	6	of	of	IN
cord-018834-4ligp4ak	112	7	endogenous	endogenous	JJ
cord-018834-4ligp4ak	112	8	and	and	CC
cord-018834-4ligp4ak	112	9	exogenous	exogenous	JJ
cord-018834-4ligp4ak	112	10	ligands	ligand	NNS
cord-018834-4ligp4ak	112	11	;	;	:
cord-018834-4ligp4ak	112	12	in	in	IN
cord-018834-4ligp4ak	112	13	particular	particular	JJ
cord-018834-4ligp4ak	112	14	,	,	,
cord-018834-4ligp4ak	112	15	glycation	glycation	NN
cord-018834-4ligp4ak	112	16	of	of	IN
cord-018834-4ligp4ak	112	17	Lys	Lys	NNP
cord-018834-4ligp4ak	112	18	199	199	CD
cord-018834-4ligp4ak	112	19	enhances	enhance	VBZ
cord-018834-4ligp4ak	112	20	warfarin	warfarin	NN
cord-018834-4ligp4ak	112	21	binding	binding	NN
cord-018834-4ligp4ak	112	22	,	,	,
cord-018834-4ligp4ak	112	23	but	but	CC
cord-018834-4ligp4ak	112	24	decreases	decrease	VBZ
cord-018834-4ligp4ak	112	25	bilirubin	bilirubin	NN
cord-018834-4ligp4ak	112	26	affi	affi	NNP
cord-018834-4ligp4ak	112	27	nity	nity	NNP
cord-018834-4ligp4ak	112	28	[	[	-LRB-
cord-018834-4ligp4ak	112	29	13	13	CD
cord-018834-4ligp4ak	112	30	]	]	-RRB-
cord-018834-4ligp4ak	112	31	.	.	.
cord-018834-4ligp4ak	113	1	Several	several	JJ
cord-018834-4ligp4ak	113	2	receptors	receptor	NNS
cord-018834-4ligp4ak	113	3	for	for	IN
cord-018834-4ligp4ak	113	4	advanced	advanced	JJ
cord-018834-4ligp4ak	113	5	glycation	glycation	NN
cord-018834-4ligp4ak	113	6	end	end	NN
cord-018834-4ligp4ak	113	7	products	product	NNS
cord-018834-4ligp4ak	113	8	initiate	initiate	VBP
cord-018834-4ligp4ak	113	9	intracellular	intracellular	JJ
cord-018834-4ligp4ak	113	10	signaling	signaling	NN
cord-018834-4ligp4ak	113	11	and	and	CC
cord-018834-4ligp4ak	113	12	enhance	enhance	VB
cord-018834-4ligp4ak	113	13	ROS	ROS	NNP
cord-018834-4ligp4ak	113	14	formation	formation	NN
cord-018834-4ligp4ak	113	15	in	in	IN
cord-018834-4ligp4ak	113	16	the	the	DT
cord-018834-4ligp4ak	113	17	cells	cell	NNS
cord-018834-4ligp4ak	113	18	through	through	IN
cord-018834-4ligp4ak	113	19	recognition	recognition	NN
cord-018834-4ligp4ak	113	20	and	and	CC
cord-018834-4ligp4ak	113	21	binding	binding	NN
cord-018834-4ligp4ak	113	22	of	of	IN
cord-018834-4ligp4ak	113	23	glycated	glycated	JJ
cord-018834-4ligp4ak	113	24	(	(	-LRB-
cord-018834-4ligp4ak	113	25	macro	macro	NN
cord-018834-4ligp4ak	113	26	)	)	-RRB-
cord-018834-4ligp4ak	113	27	molecules	molecule	NNS
cord-018834-4ligp4ak	113	28	including	include	VBG
cord-018834-4ligp4ak	113	29	HSA	HSA	NNP
cord-018834-4ligp4ak	113	30	.	.	.
cord-018834-4ligp4ak	114	1	Moreover	moreover	RB
cord-018834-4ligp4ak	114	2	,	,	,
cord-018834-4ligp4ak	114	3	hypochlorous	hypochlorous	JJ
cord-018834-4ligp4ak	114	4	acid	acid	NN
cord-018834-4ligp4ak	114	5	-	-	HYPH
cord-018834-4ligp4ak	114	6	mediated	mediate	VBN
cord-018834-4ligp4ak	114	7	carbonylation	carbonylation	NN
cord-018834-4ligp4ak	114	8	of	of	IN
cord-018834-4ligp4ak	114	9	Lys	Lys	NNP
cord-018834-4ligp4ak	114	10	residues	residue	NNS
cord-018834-4ligp4ak	114	11	of	of	IN
cord-018834-4ligp4ak	114	12	glycated	glycated	JJ
cord-018834-4ligp4ak	114	13	HSA	HSA	NNP
cord-018834-4ligp4ak	114	14	represents	represent	VBZ
cord-018834-4ligp4ak	114	15	a	a	DT
cord-018834-4ligp4ak	114	16	major	major	JJ
cord-018834-4ligp4ak	114	17	antigenic	antigenic	JJ
cord-018834-4ligp4ak	114	18	advanced	advanced	JJ
cord-018834-4ligp4ak	114	19	glycation	glycation	NN
cord-018834-4ligp4ak	114	20	end	end	NN
cord-018834-4ligp4ak	114	21	product	product	NN
cord-018834-4ligp4ak	114	22	in	in	IN
cord-018834-4ligp4ak	114	23	hyperglycemia	hyperglycemia	NN
cord-018834-4ligp4ak	114	24	and	and	CC
cord-018834-4ligp4ak	114	25	in	in	IN
cord-018834-4ligp4ak	114	26	infl	infl	NN
cord-018834-4ligp4ak	114	27	ammation	ammation	NNP
cord-018834-4ligp4ak	114	28	[	[	-LRB-
cord-018834-4ligp4ak	114	29	26	26	CD
cord-018834-4ligp4ak	114	30	]	]	-RRB-
cord-018834-4ligp4ak	114	31	.	.	.
cord-018834-4ligp4ak	115	1	Glycated	glycated	JJ
cord-018834-4ligp4ak	115	2	albumin	albumin	NN
cord-018834-4ligp4ak	115	3	was	be	VBD
cord-018834-4ligp4ak	115	4	shown	show	VBN
cord-018834-4ligp4ak	115	5	to	to	TO
cord-018834-4ligp4ak	115	6	impair	impair	VB
cord-018834-4ligp4ak	115	7	vascular	vascular	JJ
cord-018834-4ligp4ak	115	8	endothelial	endothelial	JJ
cord-018834-4ligp4ak	115	9	NO	no	DT
cord-018834-4ligp4ak	115	10	synthase	synthase	NN
cord-018834-4ligp4ak	115	11	activity	activity	NN
cord-018834-4ligp4ak	115	12	in	in	IN
cord-018834-4ligp4ak	115	13	vivo	vivo	NN
cord-018834-4ligp4ak	115	14	in	in	IN
cord-018834-4ligp4ak	115	15	aortas	aorta	NNS
cord-018834-4ligp4ak	115	16	of	of	IN
cord-018834-4ligp4ak	115	17	rabbits	rabbit	NNS
cord-018834-4ligp4ak	115	18	[	[	-LRB-
cord-018834-4ligp4ak	115	19	27	27	CD
cord-018834-4ligp4ak	115	20	]	]	-RRB-
cord-018834-4ligp4ak	115	21	.	.	.
cord-018834-4ligp4ak	116	1	Glycated	Glycated	NNP
cord-018834-4ligp4ak	116	2	HSA	HSA	NNP
cord-018834-4ligp4ak	116	3	displays	display	VBZ
cord-018834-4ligp4ak	116	4	a	a	DT
cord-018834-4ligp4ak	116	5	toxic	toxic	JJ
cord-018834-4ligp4ak	116	6	effect	effect	NN
cord-018834-4ligp4ak	116	7	on	on	IN
cord-018834-4ligp4ak	116	8	microglial	microglial	JJ
cord-018834-4ligp4ak	116	9	cells	cell	NNS
cord-018834-4ligp4ak	116	10	associated	associate	VBN
cord-018834-4ligp4ak	116	11	with	with	IN
cord-018834-4ligp4ak	116	12	impairments	impairment	NNS
cord-018834-4ligp4ak	116	13	in	in	IN
cord-018834-4ligp4ak	116	14	cellular	cellular	JJ
cord-018834-4ligp4ak	116	15	proteolytic	proteolytic	JJ
cord-018834-4ligp4ak	116	16	systems	system	NNS
cord-018834-4ligp4ak	116	17	,	,	,
cord-018834-4ligp4ak	116	18	possibly	possibly	RB
cord-018834-4ligp4ak	116	19	refl	refl	VB
cord-018834-4ligp4ak	116	20	ecting	ecte	VBG
cord-018834-4ligp4ak	116	21	the	the	DT
cord-018834-4ligp4ak	116	22	role	role	NN
cord-018834-4ligp4ak	116	23	of	of	IN
cord-018834-4ligp4ak	116	24	advanced	advanced	JJ
cord-018834-4ligp4ak	116	25	glycation	glycation	NN
cord-018834-4ligp4ak	116	26	end	end	NN
cord-018834-4ligp4ak	116	27	products	product	NNS
cord-018834-4ligp4ak	116	28	in	in	IN
cord-018834-4ligp4ak	116	29	neurodegenation	neurodegenation	NN
cord-018834-4ligp4ak	116	30	.	.	.
cord-018834-4ligp4ak	117	1	HSA	HSA	NNP
cord-018834-4ligp4ak	117	2	may	may	MD
cord-018834-4ligp4ak	117	3	protect	protect	VB
cord-018834-4ligp4ak	117	4	other	other	JJ
cord-018834-4ligp4ak	117	5	proteins	protein	NNS
cord-018834-4ligp4ak	117	6	including	include	VBG
cord-018834-4ligp4ak	117	7	hemoglobin	hemoglobin	NN
cord-018834-4ligp4ak	117	8	,	,	,
cord-018834-4ligp4ak	117	9	insulin	insulin	NN
cord-018834-4ligp4ak	117	10	,	,	,
cord-018834-4ligp4ak	117	11	and	and	CC
cord-018834-4ligp4ak	117	12	immunoglobin	immunoglobin	NNP
cord-018834-4ligp4ak	117	13	from	from	IN
cord-018834-4ligp4ak	117	14	glycation	glycation	NN
cord-018834-4ligp4ak	117	15	in	in	IN
cord-018834-4ligp4ak	117	16	the	the	DT
cord-018834-4ligp4ak	117	17	early	early	JJ
cord-018834-4ligp4ak	117	18	stages	stage	NNS
cord-018834-4ligp4ak	117	19	of	of	IN
cord-018834-4ligp4ak	117	20	diabetes	diabete	NNS
cord-018834-4ligp4ak	117	21	due	due	IN
cord-018834-4ligp4ak	117	22	to	to	IN
cord-018834-4ligp4ak	117	23	its	-PRON-	PRP$
cord-018834-4ligp4ak	117	24	long	long	JJ
cord-018834-4ligp4ak	117	25	half	half	JJ
cord-018834-4ligp4ak	117	26	-	-	HYPH
cord-018834-4ligp4ak	117	27	life	life	NN
cord-018834-4ligp4ak	117	28	and	and	CC
cord-018834-4ligp4ak	117	29	its	-PRON-	PRP$
cord-018834-4ligp4ak	117	30	high	high	JJ
cord-018834-4ligp4ak	117	31	concentrations	concentration	NNS
cord-018834-4ligp4ak	117	32	compared	compare	VBN
cord-018834-4ligp4ak	117	33	to	to	IN
cord-018834-4ligp4ak	117	34	other	other	JJ
cord-018834-4ligp4ak	117	35	proteins	protein	NNS
cord-018834-4ligp4ak	117	36	[	[	-LRB-
cord-018834-4ligp4ak	117	37	28	28	CD
cord-018834-4ligp4ak	117	38	]	]	-RRB-
cord-018834-4ligp4ak	117	39	.	.	.
cord-018834-4ligp4ak	118	1	The	the	DT
cord-018834-4ligp4ak	118	2	irreversible	irreversible	JJ
cord-018834-4ligp4ak	118	3	damages	damage	NNS
cord-018834-4ligp4ak	118	4	associated	associate	VBN
cord-018834-4ligp4ak	118	5	with	with	IN
cord-018834-4ligp4ak	118	6	diabetes	diabetes	NN
cord-018834-4ligp4ak	118	7	such	such	JJ
cord-018834-4ligp4ak	118	8	as	as	IN
cord-018834-4ligp4ak	118	9	retinopathy	retinopathy	NN
cord-018834-4ligp4ak	118	10	,	,	,
cord-018834-4ligp4ak	118	11	nephropathy	nephropathy	NN
cord-018834-4ligp4ak	118	12	,	,	,
cord-018834-4ligp4ak	118	13	neuropathy	neuropathy	NN
cord-018834-4ligp4ak	118	14	,	,	,
cord-018834-4ligp4ak	118	15	and	and	CC
cord-018834-4ligp4ak	118	16	coronary	coronary	JJ
cord-018834-4ligp4ak	118	17	artery	artery	NN
cord-018834-4ligp4ak	118	18	disease	disease	NN
cord-018834-4ligp4ak	118	19	could	could	MD
cord-018834-4ligp4ak	118	20	be	be	VB
cord-018834-4ligp4ak	118	21	attributed	attribute	VBN
cord-018834-4ligp4ak	118	22	to	to	IN
cord-018834-4ligp4ak	118	23	reduced	reduce	VBN
cord-018834-4ligp4ak	118	24	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	118	25	properties	property	NNS
cord-018834-4ligp4ak	118	26	of	of	IN
cord-018834-4ligp4ak	118	27	glycated	glycated	JJ
cord-018834-4ligp4ak	118	28	HSA	HSA	NNP
cord-018834-4ligp4ak	118	29	.	.	.
cord-018834-4ligp4ak	119	1	Alterations	alteration	NNS
cord-018834-4ligp4ak	119	2	in	in	IN
cord-018834-4ligp4ak	119	3	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	119	4	properties	property	NNS
cord-018834-4ligp4ak	119	5	of	of	IN
cord-018834-4ligp4ak	119	6	HSA	HSA	NNP
cord-018834-4ligp4ak	119	7	were	be	VBD
cord-018834-4ligp4ak	119	8	very	very	RB
cord-018834-4ligp4ak	119	9	recently	recently	RB
cord-018834-4ligp4ak	119	10	identifi	identifi	VBN
cord-018834-4ligp4ak	119	11	ed	ed	NN
cord-018834-4ligp4ak	119	12	in	in	IN
cord-018834-4ligp4ak	119	13	vivo	vivo	NN
cord-018834-4ligp4ak	119	14	in	in	IN
cord-018834-4ligp4ak	119	15	patients	patient	NNS
cord-018834-4ligp4ak	119	16	with	with	IN
cord-018834-4ligp4ak	119	17	obstructive	obstructive	JJ
cord-018834-4ligp4ak	119	18	sleep	sleep	NN
cord-018834-4ligp4ak	119	19	apnea	apnea	NN
cord-018834-4ligp4ak	119	20	syndrome	syndrome	NN
cord-018834-4ligp4ak	119	21	.	.	.
cord-018834-4ligp4ak	120	1	This	this	DT
cord-018834-4ligp4ak	120	2	refl	refl	FW
cord-018834-4ligp4ak	120	3	ects	ect	VBZ
cord-018834-4ligp4ak	120	4	the	the	DT
cord-018834-4ligp4ak	120	5	impaired	impaired	JJ
cord-018834-4ligp4ak	120	6	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	120	7	HSA	HSA	NNP
cord-018834-4ligp4ak	120	8	activity	activity	NN
cord-018834-4ligp4ak	120	9	,	,	,
cord-018834-4ligp4ak	120	10	which	which	WDT
cord-018834-4ligp4ak	120	11	is	be	VBZ
cord-018834-4ligp4ak	120	12	associated	associate	VBN
cord-018834-4ligp4ak	120	13	with	with	IN
cord-018834-4ligp4ak	120	14	the	the	DT
cord-018834-4ligp4ak	120	15	enhanced	enhance	VBN
cord-018834-4ligp4ak	120	16	glycation	glycation	NN
cord-018834-4ligp4ak	120	17	level	level	NN
cord-018834-4ligp4ak	120	18	of	of	IN
cord-018834-4ligp4ak	120	19	HSA	HSA	NNP
cord-018834-4ligp4ak	120	20	in	in	IN
cord-018834-4ligp4ak	120	21	patients	patient	NNS
cord-018834-4ligp4ak	120	22	with	with	IN
cord-018834-4ligp4ak	120	23	obstructive	obstructive	JJ
cord-018834-4ligp4ak	120	24	sleep	sleep	NN
cord-018834-4ligp4ak	120	25	apnea	apnea	NN
cord-018834-4ligp4ak	120	26	syndrome	syndrome	NN
cord-018834-4ligp4ak	120	27	.	.	.
cord-018834-4ligp4ak	121	1	That	that	DT
cord-018834-4ligp4ak	121	2	might	may	MD
cord-018834-4ligp4ak	121	3	have	have	VB
cord-018834-4ligp4ak	121	4	increased	increase	VBN
cord-018834-4ligp4ak	121	5	the	the	DT
cord-018834-4ligp4ak	121	6	perioperative	perioperative	JJ
cord-018834-4ligp4ak	121	7	risks	risk	NNS
cord-018834-4ligp4ak	121	8	in	in	IN
cord-018834-4ligp4ak	121	9	those	those	DT
cord-018834-4ligp4ak	121	10	patients	patient	NNS
cord-018834-4ligp4ak	121	11	[	[	-LRB-
cord-018834-4ligp4ak	121	12	29	29	CD
cord-018834-4ligp4ak	121	13	]	]	-RRB-
cord-018834-4ligp4ak	121	14	.	.	.
cord-018834-4ligp4ak	122	1	HSA	HSA	NNP
cord-018834-4ligp4ak	122	2	has	have	VBZ
cord-018834-4ligp4ak	122	3	anticoagulant	anticoagulant	JJ
cord-018834-4ligp4ak	122	4	and	and	CC
cord-018834-4ligp4ak	122	5	antithrombotic	antithrombotic	JJ
cord-018834-4ligp4ak	122	6	functions	function	NNS
cord-018834-4ligp4ak	122	7	.	.	.
cord-018834-4ligp4ak	123	1	These	these	DT
cord-018834-4ligp4ak	123	2	functions	function	NNS
cord-018834-4ligp4ak	123	3	may	may	MD
cord-018834-4ligp4ak	123	4	in	in	IN
cord-018834-4ligp4ak	123	5	part	part	NN
cord-018834-4ligp4ak	123	6	be	be	VB
cord-018834-4ligp4ak	123	7	mediated	mediate	VBN
cord-018834-4ligp4ak	123	8	by	by	IN
cord-018834-4ligp4ak	123	9	the	the	DT
cord-018834-4ligp4ak	123	10	HSA	HSA	NNP
cord-018834-4ligp4ak	123	11	capacity	capacity	NN
cord-018834-4ligp4ak	123	12	to	to	TO
cord-018834-4ligp4ak	123	13	bind	bind	VB
cord-018834-4ligp4ak	123	14	NO	no	DT
cord-018834-4ligp4ak	123	15	forming	form	VBG
cord-018834-4ligp4ak	123	16	S	s	NN
cord-018834-4ligp4ak	123	17	-	-	HYPH
cord-018834-4ligp4ak	123	18	nitrosothiols	nitrosothiol	NNS
cord-018834-4ligp4ak	123	19	,	,	,
cord-018834-4ligp4ak	123	20	thereby	thereby	RB
cord-018834-4ligp4ak	123	21	inhibiting	inhibit	VBG
cord-018834-4ligp4ak	123	22	the	the	DT
cord-018834-4ligp4ak	123	23	rapid	rapid	JJ
cord-018834-4ligp4ak	123	24	inactivation	inactivation	NN
cord-018834-4ligp4ak	123	25	of	of	IN
cord-018834-4ligp4ak	123	26	NO	no	NN
cord-018834-4ligp4ak	123	27	and	and	CC
cord-018834-4ligp4ak	123	28	allowing	allow	VBG
cord-018834-4ligp4ak	123	29	prolongation	prolongation	NN
cord-018834-4ligp4ak	123	30	of	of	IN
cord-018834-4ligp4ak	123	31	its	-PRON-	PRP$
cord-018834-4ligp4ak	123	32	antiaggregatory	antiaggregatory	NN
cord-018834-4ligp4ak	123	33	effects	effect	NNS
cord-018834-4ligp4ak	123	34	on	on	IN
cord-018834-4ligp4ak	123	35	platelets	platelet	NNS
cord-018834-4ligp4ak	123	36	[	[	-LRB-
cord-018834-4ligp4ak	123	37	30	30	CD
cord-018834-4ligp4ak	123	38	]	]	-RRB-
cord-018834-4ligp4ak	123	39	.	.	.
cord-018834-4ligp4ak	124	1	Therefore	therefore	RB
cord-018834-4ligp4ak	124	2	,	,	,
cord-018834-4ligp4ak	124	3	the	the	DT
cord-018834-4ligp4ak	124	4	use	use	NN
cord-018834-4ligp4ak	124	5	of	of	IN
cord-018834-4ligp4ak	124	6	HSA	HSA	NNP
cord-018834-4ligp4ak	124	7	might	may	MD
cord-018834-4ligp4ak	124	8	be	be	VB
cord-018834-4ligp4ak	124	9	very	very	RB
cord-018834-4ligp4ak	124	10	benefi	benefi	JJ
cord-018834-4ligp4ak	124	11	cial	cial	NN
cord-018834-4ligp4ak	124	12	in	in	IN
cord-018834-4ligp4ak	124	13	cases	case	NNS
cord-018834-4ligp4ak	124	14	with	with	IN
cord-018834-4ligp4ak	124	15	hypercoagulable	hypercoagulable	JJ
cord-018834-4ligp4ak	124	16	conditions	condition	NNS
cord-018834-4ligp4ak	124	17	such	such	JJ
cord-018834-4ligp4ak	124	18	as	as	IN
cord-018834-4ligp4ak	124	19	during	during	IN
cord-018834-4ligp4ak	124	20	the	the	DT
cord-018834-4ligp4ak	124	21	perioperative	perioperative	JJ
cord-018834-4ligp4ak	124	22	period	period	NN
cord-018834-4ligp4ak	124	23	.	.	.
cord-018834-4ligp4ak	125	1	The	the	DT
cord-018834-4ligp4ak	125	2	interaction	interaction	NN
cord-018834-4ligp4ak	125	3	between	between	IN
cord-018834-4ligp4ak	125	4	HSA	HSA	NNP
cord-018834-4ligp4ak	125	5	and	and	CC
cord-018834-4ligp4ak	125	6	another	another	DT
cord-018834-4ligp4ak	125	7	molecule	molecule	NN
cord-018834-4ligp4ak	125	8	results	result	NNS
cord-018834-4ligp4ak	125	9	in	in	IN
cord-018834-4ligp4ak	125	10	enzymatic	enzymatic	JJ
cord-018834-4ligp4ak	125	11	activity	activity	NN
cord-018834-4ligp4ak	125	12	.	.	.
cord-018834-4ligp4ak	126	1	This	this	DT
cord-018834-4ligp4ak	126	2	property	property	NN
cord-018834-4ligp4ak	126	3	of	of	IN
cord-018834-4ligp4ak	126	4	HSA	HSA	NNP
cord-018834-4ligp4ak	126	5	is	be	VBZ
cord-018834-4ligp4ak	126	6	called	call	VBN
cord-018834-4ligp4ak	126	7	an	an	DT
cord-018834-4ligp4ak	126	8	enzyme	enzyme	NN
cord-018834-4ligp4ak	126	9	-	-	HYPH
cord-018834-4ligp4ak	126	10	like	like	JJ
cord-018834-4ligp4ak	126	11	or	or	CC
cord-018834-4ligp4ak	126	12	a	a	DT
cord-018834-4ligp4ak	126	13	pseudo	pseudo	JJ
cord-018834-4ligp4ak	126	14	-	-	JJ
cord-018834-4ligp4ak	126	15	enzymatic	enzymatic	JJ
cord-018834-4ligp4ak	126	16	activity	activity	NN
cord-018834-4ligp4ak	126	17	.	.	.
cord-018834-4ligp4ak	127	1	The	the	DT
cord-018834-4ligp4ak	127	2	esterase	esterase	NN
cord-018834-4ligp4ak	127	3	activity	activity	NN
cord-018834-4ligp4ak	127	4	involving	involve	VBG
cord-018834-4ligp4ak	127	5	lysine	lysine	NN
cord-018834-4ligp4ak	127	6	(	(	-LRB-
cord-018834-4ligp4ak	127	7	Lys	Lys	NNP
cord-018834-4ligp4ak	127	8	)	)	-RRB-
cord-018834-4ligp4ak	127	9	199	199	CD
cord-018834-4ligp4ak	127	10	is	be	VBZ
cord-018834-4ligp4ak	127	11	able	able	JJ
cord-018834-4ligp4ak	127	12	to	to	TO
cord-018834-4ligp4ak	127	13	split	split	VB
cord-018834-4ligp4ak	127	14	acetylsalicylic	acetylsalicylic	JJ
cord-018834-4ligp4ak	127	15	acid	acid	NN
cord-018834-4ligp4ak	127	16	(	(	-LRB-
cord-018834-4ligp4ak	127	17	aspirin	aspirin	NN
cord-018834-4ligp4ak	127	18	)	)	-RRB-
cord-018834-4ligp4ak	127	19	into	into	IN
cord-018834-4ligp4ak	127	20	salicylic	salicylic	JJ
cord-018834-4ligp4ak	127	21	acid	acid	NN
cord-018834-4ligp4ak	127	22	,	,	,
cord-018834-4ligp4ak	127	23	which	which	WDT
cord-018834-4ligp4ak	127	24	is	be	VBZ
cord-018834-4ligp4ak	127	25	released	release	VBN
cord-018834-4ligp4ak	127	26	and	and	CC
cord-018834-4ligp4ak	127	27	the	the	DT
cord-018834-4ligp4ak	127	28	acetyl	acetyl	NN
cord-018834-4ligp4ak	127	29	group	group	NN
cord-018834-4ligp4ak	127	30	is	be	VBZ
cord-018834-4ligp4ak	127	31	transferred	transfer	VBN
cord-018834-4ligp4ak	127	32	to	to	IN
cord-018834-4ligp4ak	127	33	especially	especially	RB
cord-018834-4ligp4ak	127	34	Lys	Lys	NNP
cord-018834-4ligp4ak	127	35	199	199	CD
cord-018834-4ligp4ak	127	36	.	.	.
cord-018834-4ligp4ak	128	1	Therefore	therefore	RB
cord-018834-4ligp4ak	128	2	,	,	,
cord-018834-4ligp4ak	128	3	aspirin	aspirin	NN
cord-018834-4ligp4ak	128	4	but	but	CC
cord-018834-4ligp4ak	128	5	not	not	RB
cord-018834-4ligp4ak	128	6	other	other	JJ
cord-018834-4ligp4ak	128	7	salicylates	salicylate	NNS
cord-018834-4ligp4ak	128	8	induce	induce	VBP
cord-018834-4ligp4ak	128	9	the	the	DT
cord-018834-4ligp4ak	128	10	aspirin	aspirin	NN
cord-018834-4ligp4ak	128	11	resistance	resistance	NN
cord-018834-4ligp4ak	128	12	syndrome	syndrome	NN
cord-018834-4ligp4ak	128	13	,	,	,
cord-018834-4ligp4ak	128	14	as	as	IN
cord-018834-4ligp4ak	128	15	the	the	DT
cord-018834-4ligp4ak	128	16	acetylation	acetylation	NN
cord-018834-4ligp4ak	128	17	of	of	IN
cord-018834-4ligp4ak	128	18	albumin	albumin	NN
cord-018834-4ligp4ak	128	19	molecule	molecule	NN
cord-018834-4ligp4ak	128	20	can	can	MD
cord-018834-4ligp4ak	128	21	be	be	VB
cord-018834-4ligp4ak	128	22	allergic	allergic	JJ
cord-018834-4ligp4ak	128	23	.	.	.
cord-018834-4ligp4ak	129	1	Asthma	asthma	NN
cord-018834-4ligp4ak	129	2	,	,	,
cord-018834-4ligp4ak	129	3	rhinitis	rhinitis	NN
cord-018834-4ligp4ak	129	4	,	,	,
cord-018834-4ligp4ak	129	5	and	and	CC
cord-018834-4ligp4ak	129	6	nasal	nasal	NN
cord-018834-4ligp4ak	129	7	polyps	polyp	NNS
cord-018834-4ligp4ak	129	8	characterize	characterize	VBP
cord-018834-4ligp4ak	129	9	aspirin	aspirin	NN
cord-018834-4ligp4ak	129	10	resistance	resistance	NN
cord-018834-4ligp4ak	129	11	syndrome	syndrome	NN
cord-018834-4ligp4ak	129	12	.	.	.
cord-018834-4ligp4ak	130	1	Moreover	moreover	RB
cord-018834-4ligp4ak	130	2	,	,	,
cord-018834-4ligp4ak	130	3	Lys	Lys	NNP
cord-018834-4ligp4ak	130	4	199	199	CD
cord-018834-4ligp4ak	130	5	and	and	CC
cord-018834-4ligp4ak	130	6	penicillins	penicillin	NNS
cord-018834-4ligp4ak	130	7	can	can	MD
cord-018834-4ligp4ak	130	8	covalently	covalently	RB
cord-018834-4ligp4ak	130	9	bind	bind	VB
cord-018834-4ligp4ak	130	10	via	via	IN
cord-018834-4ligp4ak	130	11	an	an	DT
cord-018834-4ligp4ak	130	12	aminolysis	aminolysis	NN
cord-018834-4ligp4ak	130	13	,	,	,
cord-018834-4ligp4ak	130	14	generating	generate	VBG
cord-018834-4ligp4ak	130	15	a	a	DT
cord-018834-4ligp4ak	130	16	penicilloylcontaining	penicilloylcontaining	NN
cord-018834-4ligp4ak	130	17	peptide	peptide	NN
cord-018834-4ligp4ak	130	18	.	.	.
cord-018834-4ligp4ak	131	1	The	the	DT
cord-018834-4ligp4ak	131	2	covalent	covalent	JJ
cord-018834-4ligp4ak	131	3	labeling	labeling	NN
cord-018834-4ligp4ak	131	4	of	of	IN
cord-018834-4ligp4ak	131	5	Lys	Lys	NNP
cord-018834-4ligp4ak	131	6	199	199	CD
cord-018834-4ligp4ak	131	7	can	can	MD
cord-018834-4ligp4ak	131	8	have	have	VB
cord-018834-4ligp4ak	131	9	clinical	clinical	JJ
cord-018834-4ligp4ak	131	10	consequences	consequence	NNS
cord-018834-4ligp4ak	131	11	.	.	.
cord-018834-4ligp4ak	132	1	The	the	DT
cord-018834-4ligp4ak	132	2	penicilloyl	penicilloyl	JJ
cord-018834-4ligp4ak	132	3	-	-	HYPH
cord-018834-4ligp4ak	132	4	HSA	HSA	NNP
cord-018834-4ligp4ak	132	5	complex	complex	NN
cord-018834-4ligp4ak	132	6	has	have	VBZ
cord-018834-4ligp4ak	132	7	no	no	DT
cord-018834-4ligp4ak	132	8	antibacterial	antibacterial	JJ
cord-018834-4ligp4ak	132	9	activity	activity	NN
cord-018834-4ligp4ak	132	10	;	;	:
cord-018834-4ligp4ak	132	11	however	however	RB
cord-018834-4ligp4ak	132	12	,	,	,
cord-018834-4ligp4ak	132	13	it	-PRON-	PRP
cord-018834-4ligp4ak	132	14	represents	represent	VBZ
cord-018834-4ligp4ak	132	15	the	the	DT
cord-018834-4ligp4ak	132	16	major	major	JJ
cord-018834-4ligp4ak	132	17	antigenic	antigenic	JJ
cord-018834-4ligp4ak	132	18	determinant	determinant	NN
cord-018834-4ligp4ak	132	19	of	of	IN
cord-018834-4ligp4ak	132	20	penicillin	penicillin	NN
cord-018834-4ligp4ak	132	21	allergy	allergy	NN
cord-018834-4ligp4ak	132	22	.	.	.
cord-018834-4ligp4ak	133	1	HSA	HSA	NNP
cord-018834-4ligp4ak	133	2	acts	act	VBZ
cord-018834-4ligp4ak	133	3	as	as	IN
cord-018834-4ligp4ak	133	4	a	a	DT
cord-018834-4ligp4ak	133	5	phosphotriesterase	phosphotriesterase	NN
cord-018834-4ligp4ak	133	6	activity	activity	NN
cord-018834-4ligp4ak	133	7	,	,	,
cord-018834-4ligp4ak	133	8	which	which	WDT
cord-018834-4ligp4ak	133	9	thereby	thereby	RB
cord-018834-4ligp4ak	133	10	inactivates	inactivate	VBZ
cord-018834-4ligp4ak	133	11	organophosphorus	organophosphorus	JJ
cord-018834-4ligp4ak	133	12	compounds	compound	NNS
cord-018834-4ligp4ak	133	13	.	.	.
cord-018834-4ligp4ak	134	1	HSA	HSA	NNP
cord-018834-4ligp4ak	134	2	can	can	MD
cord-018834-4ligp4ak	134	3	catalyze	catalyze	VB
cord-018834-4ligp4ak	134	4	RNA	RNA	NNP
cord-018834-4ligp4ak	134	5	phosphodiester	phosphodiester	NN
cord-018834-4ligp4ak	134	6	bond	bond	NN
cord-018834-4ligp4ak	134	7	cleavage	cleavage	NN
cord-018834-4ligp4ak	134	8	;	;	:
cord-018834-4ligp4ak	134	9	therefore	therefore	RB
cord-018834-4ligp4ak	134	10	,	,	,
cord-018834-4ligp4ak	134	11	it	-PRON-	PRP
cord-018834-4ligp4ak	134	12	participates	participate	VBZ
cord-018834-4ligp4ak	134	13	in	in	IN
cord-018834-4ligp4ak	134	14	the	the	DT
cord-018834-4ligp4ak	134	15	degradation	degradation	NN
cord-018834-4ligp4ak	134	16	of	of	IN
cord-018834-4ligp4ak	134	17	endogenous	endogenous	JJ
cord-018834-4ligp4ak	134	18	extracellular	extracellular	JJ
cord-018834-4ligp4ak	134	19	RNA	RNA	NNP
cord-018834-4ligp4ak	134	20	and	and	CC
cord-018834-4ligp4ak	134	21	of	of	IN
cord-018834-4ligp4ak	134	22	circulating	circulate	VBG
cord-018834-4ligp4ak	134	23	pathogenic	pathogenic	JJ
cord-018834-4ligp4ak	134	24	nucleic	nucleic	JJ
cord-018834-4ligp4ak	134	25	acids	acid	NNS
cord-018834-4ligp4ak	134	26	.	.	.
cord-018834-4ligp4ak	135	1	HSA	HSA	NNP
cord-018834-4ligp4ak	135	2	possesses	possess	VBZ
cord-018834-4ligp4ak	135	3	enolase	enolase	JJ
cord-018834-4ligp4ak	135	4	activity	activity	NN
cord-018834-4ligp4ak	135	5	toward	toward	IN
cord-018834-4ligp4ak	135	6	dihydrotestosterone	dihydrotestosterone	NN
cord-018834-4ligp4ak	135	7	,	,	,
cord-018834-4ligp4ak	135	8	converting	convert	VBG
cord-018834-4ligp4ak	135	9	it	-PRON-	PRP
cord-018834-4ligp4ak	135	10	from	from	IN
cord-018834-4ligp4ak	135	11	the	the	DT
cord-018834-4ligp4ak	135	12	3-keto	3-keto	CD
cord-018834-4ligp4ak	135	13	to	to	IN
cord-018834-4ligp4ak	135	14	the	the	DT
cord-018834-4ligp4ak	135	15	3-enol	3-enol	CD
cord-018834-4ligp4ak	135	16	form	form	NN
cord-018834-4ligp4ak	135	17	.	.	.
cord-018834-4ligp4ak	136	1	In	in	IN
cord-018834-4ligp4ak	136	2	addition	addition	NN
cord-018834-4ligp4ak	136	3	,	,	,
cord-018834-4ligp4ak	136	4	HSA	HSA	NNP
cord-018834-4ligp4ak	136	5	facilitates	facilitate	VBZ
cord-018834-4ligp4ak	136	6	the	the	DT
cord-018834-4ligp4ak	136	7	isomerization	isomerization	NN
cord-018834-4ligp4ak	136	8	and	and	CC
cord-018834-4ligp4ak	136	9	the	the	DT
cord-018834-4ligp4ak	136	10	stereoselective	stereoselective	JJ
cord-018834-4ligp4ak	136	11	hydrolysis	hydrolysis	NN
cord-018834-4ligp4ak	136	12	of	of	IN
cord-018834-4ligp4ak	136	13	glucuronide	glucuronide	NN
cord-018834-4ligp4ak	136	14	conjugates	conjugate	NNS
cord-018834-4ligp4ak	136	15	and	and	CC
cord-018834-4ligp4ak	136	16	the	the	DT
cord-018834-4ligp4ak	136	17	removal	removal	NN
cord-018834-4ligp4ak	136	18	of	of	IN
cord-018834-4ligp4ak	136	19	glucuronide	glucuronide	NNP
cord-018834-4ligp4ak	136	20	conjugates	conjugate	NNS
cord-018834-4ligp4ak	136	21	,	,	,
cord-018834-4ligp4ak	136	22	thereby	thereby	RB
cord-018834-4ligp4ak	136	23	reducing	reduce	VBG
cord-018834-4ligp4ak	136	24	their	-PRON-	PRP$
cord-018834-4ligp4ak	136	25	plasma	plasma	NN
cord-018834-4ligp4ak	136	26	levels	level	NNS
cord-018834-4ligp4ak	136	27	by	by	IN
cord-018834-4ligp4ak	136	28	reversible	reversible	JJ
cord-018834-4ligp4ak	136	29	and/or	and/or	CC
cord-018834-4ligp4ak	136	30	irreversible	irreversible	JJ
cord-018834-4ligp4ak	136	31	binding	binding	NN
cord-018834-4ligp4ak	136	32	.	.	.
cord-018834-4ligp4ak	137	1	Finally	finally	RB
cord-018834-4ligp4ak	137	2	,	,	,
cord-018834-4ligp4ak	137	3	HSA	HSA	NNP
cord-018834-4ligp4ak	137	4	seems	seem	VBZ
cord-018834-4ligp4ak	137	5	to	to	TO
cord-018834-4ligp4ak	137	6	have	have	VB
cord-018834-4ligp4ak	137	7	a	a	DT
cord-018834-4ligp4ak	137	8	signifi	signifi	NN
cord-018834-4ligp4ak	138	1	ca	can	MD
cord-018834-4ligp4ak	138	2	nt	not	RB
cord-018834-4ligp4ak	138	3	role	role	VB
cord-018834-4ligp4ak	138	4	in	in	IN
cord-018834-4ligp4ak	138	5	both	both	CC
cord-018834-4ligp4ak	138	6	the	the	DT
cord-018834-4ligp4ak	138	7	biosynthesis	biosynthesis	NN
cord-018834-4ligp4ak	138	8	and	and	CC
cord-018834-4ligp4ak	138	9	the	the	DT
cord-018834-4ligp4ak	138	10	elimination	elimination	NN
cord-018834-4ligp4ak	138	11	the	the	DT
cord-018834-4ligp4ak	138	12	prostaglandins	prostaglandin	NNS
cord-018834-4ligp4ak	138	13	.	.	.
cord-018834-4ligp4ak	139	1	HSA	HSA	NNP
cord-018834-4ligp4ak	139	2	has	have	VBZ
cord-018834-4ligp4ak	139	3	no	no	DT
cord-018834-4ligp4ak	139	4	enzymatic	enzymatic	JJ
cord-018834-4ligp4ak	139	5	effects	effect	NNS
cord-018834-4ligp4ak	139	6	on	on	IN
cord-018834-4ligp4ak	139	7	leukotrienes	leukotriene	NNS
cord-018834-4ligp4ak	139	8	or	or	CC
cord-018834-4ligp4ak	139	9	thromboxanes	thromboxane	NNS
cord-018834-4ligp4ak	139	10	.	.	.
cord-018834-4ligp4ak	140	1	However	however	RB
cord-018834-4ligp4ak	140	2	,	,	,
cord-018834-4ligp4ak	140	3	it	-PRON-	PRP
cord-018834-4ligp4ak	140	4	binds	bind	VBZ
cord-018834-4ligp4ak	140	5	and	and	CC
cord-018834-4ligp4ak	140	6	thereby	thereby	RB
cord-018834-4ligp4ak	140	7	stabilizes	stabilize	VBZ
cord-018834-4ligp4ak	140	8	thromboxane	thromboxane	NN
cord-018834-4ligp4ak	140	9	A	a	DT
cord-018834-4ligp4ak	140	10	2	2	CD
cord-018834-4ligp4ak	140	11	.	.	.
cord-018834-4ligp4ak	141	1	Binding	binding	NN
cord-018834-4ligp4ak	141	2	could	could	MD
cord-018834-4ligp4ak	141	3	play	play	VB
cord-018834-4ligp4ak	141	4	a	a	DT
cord-018834-4ligp4ak	141	5	major	major	JJ
cord-018834-4ligp4ak	141	6	role	role	NN
cord-018834-4ligp4ak	141	7	for	for	IN
cord-018834-4ligp4ak	141	8	the	the	DT
cord-018834-4ligp4ak	141	9	inactivation	inactivation	NN
cord-018834-4ligp4ak	141	10	of	of	IN
cord-018834-4ligp4ak	141	11	these	these	DT
cord-018834-4ligp4ak	141	12	potent	potent	JJ
cord-018834-4ligp4ak	141	13	compounds	compound	NNS
cord-018834-4ligp4ak	141	14	,	,	,
cord-018834-4ligp4ak	141	15	diminishing	diminish	VBG
cord-018834-4ligp4ak	141	16	the	the	DT
cord-018834-4ligp4ak	141	17	biological	biological	JJ
cord-018834-4ligp4ak	141	18	activities	activity	NNS
cord-018834-4ligp4ak	141	19	of	of	IN
cord-018834-4ligp4ak	141	20	substances	substance	NNS
cord-018834-4ligp4ak	141	21	that	that	WDT
cord-018834-4ligp4ak	141	22	may	may	MD
cord-018834-4ligp4ak	141	23	be	be	VB
cord-018834-4ligp4ak	141	24	harmful	harmful	JJ
cord-018834-4ligp4ak	141	25	for	for	IN
cord-018834-4ligp4ak	141	26	the	the	DT
cord-018834-4ligp4ak	141	27	body	body	NN
cord-018834-4ligp4ak	141	28	if	if	IN
cord-018834-4ligp4ak	141	29	present	present	JJ
cord-018834-4ligp4ak	141	30	in	in	IN
cord-018834-4ligp4ak	141	31	too	too	RB
cord-018834-4ligp4ak	141	32	large	large	JJ
cord-018834-4ligp4ak	141	33	amounts	amount	NNS
cord-018834-4ligp4ak	141	34	[	[	-LRB-
cord-018834-4ligp4ak	141	35	6	6	CD
cord-018834-4ligp4ak	141	36	,	,	,
cord-018834-4ligp4ak	141	37	13	13	CD
cord-018834-4ligp4ak	141	38	]	]	-RRB-
cord-018834-4ligp4ak	141	39	.	.	.
cord-018834-4ligp4ak	142	1	Hypoalbuminemia	Hypoalbuminemia	NNP
cord-018834-4ligp4ak	142	2	is	be	VBZ
cord-018834-4ligp4ak	142	3	generally	generally	RB
cord-018834-4ligp4ak	142	4	defi	defi	NNP
cord-018834-4ligp4ak	142	5	ned	ned	NNP
cord-018834-4ligp4ak	142	6	as	as	IN
cord-018834-4ligp4ak	142	7	serum	serum	NN
cord-018834-4ligp4ak	142	8	albumin	albumin	NN
cord-018834-4ligp4ak	142	9	concentration	concentration	NN
cord-018834-4ligp4ak	142	10	≤30	≤30	.
cord-018834-4ligp4ak	143	1	g	g	NNP
cord-018834-4ligp4ak	143	2	/	/	SYM
cord-018834-4ligp4ak	143	3	L	L	NNP
cord-018834-4ligp4ak	143	4	and	and	CC
cord-018834-4ligp4ak	143	5	is	be	VBZ
cord-018834-4ligp4ak	143	6	usually	usually	RB
cord-018834-4ligp4ak	143	7	very	very	RB
cord-018834-4ligp4ak	143	8	common	common	JJ
cord-018834-4ligp4ak	143	9	in	in	IN
cord-018834-4ligp4ak	143	10	critically	critically	RB
cord-018834-4ligp4ak	143	11	ill	ill	JJ
cord-018834-4ligp4ak	143	12	patients	patient	NNS
cord-018834-4ligp4ak	143	13	.	.	.
cord-018834-4ligp4ak	144	1	The	the	DT
cord-018834-4ligp4ak	144	2	albuminemia	albuminemia	NN
cord-018834-4ligp4ak	144	3	could	could	MD
cord-018834-4ligp4ak	144	4	result	result	VB
cord-018834-4ligp4ak	144	5	from	from	IN
cord-018834-4ligp4ak	144	6	increased	increase	VBN
cord-018834-4ligp4ak	144	7	loss	loss	NN
cord-018834-4ligp4ak	144	8	of	of	IN
cord-018834-4ligp4ak	144	9	HSA	HSA	NNP
cord-018834-4ligp4ak	144	10	into	into	IN
cord-018834-4ligp4ak	144	11	the	the	DT
cord-018834-4ligp4ak	144	12	gastrointestinal	gastrointestinal	JJ
cord-018834-4ligp4ak	144	13	tract	tract	NN
cord-018834-4ligp4ak	144	14	,	,	,
cord-018834-4ligp4ak	144	15	increased	increase	VBN
cord-018834-4ligp4ak	144	16	capillary	capillary	JJ
cord-018834-4ligp4ak	144	17	permeability	permeability	NN
cord-018834-4ligp4ak	144	18	leading	lead	VBG
cord-018834-4ligp4ak	144	19	to	to	IN
cord-018834-4ligp4ak	144	20	redistribution	redistribution	NN
cord-018834-4ligp4ak	144	21	from	from	IN
cord-018834-4ligp4ak	144	22	the	the	DT
cord-018834-4ligp4ak	144	23	intravascular	intravascular	NN
cord-018834-4ligp4ak	144	24	to	to	IN
cord-018834-4ligp4ak	144	25	the	the	DT
cord-018834-4ligp4ak	144	26	interstitial	interstitial	JJ
cord-018834-4ligp4ak	144	27	space	space	NN
cord-018834-4ligp4ak	144	28	,	,	,
cord-018834-4ligp4ak	144	29	and	and	CC
cord-018834-4ligp4ak	144	30	reduced	reduce	VBN
cord-018834-4ligp4ak	144	31	hepatic	hepatic	JJ
cord-018834-4ligp4ak	144	32	synthesis	synthesis	NN
cord-018834-4ligp4ak	144	33	of	of	IN
cord-018834-4ligp4ak	144	34	HSA	HSA	NNP
cord-018834-4ligp4ak	144	35	caused	cause	VBN
cord-018834-4ligp4ak	144	36	by	by	IN
cord-018834-4ligp4ak	144	37	cytokines	cytokine	NNS
cord-018834-4ligp4ak	144	38	and	and	CC
cord-018834-4ligp4ak	144	39	stress	stress	NN
cord-018834-4ligp4ak	144	40	of	of	IN
cord-018834-4ligp4ak	144	41	critical	critical	JJ
cord-018834-4ligp4ak	144	42	illness	illness	NN
cord-018834-4ligp4ak	144	43	.	.	.
cord-018834-4ligp4ak	145	1	Hypoalbuminemia	Hypoalbuminemia	NNP
cord-018834-4ligp4ak	145	2	is	be	VBZ
cord-018834-4ligp4ak	145	3	considered	consider	VBN
cord-018834-4ligp4ak	145	4	an	an	DT
cord-018834-4ligp4ak	145	5	independent	independent	JJ
cord-018834-4ligp4ak	145	6	risk	risk	NN
cord-018834-4ligp4ak	145	7	factor	factor	NN
cord-018834-4ligp4ak	145	8	for	for	IN
cord-018834-4ligp4ak	145	9	worse	bad	JJR
cord-018834-4ligp4ak	145	10	outcomes	outcome	NNS
cord-018834-4ligp4ak	145	11	in	in	IN
cord-018834-4ligp4ak	145	12	critically	critically	RB
cord-018834-4ligp4ak	145	13	ill	ill	JJ
cord-018834-4ligp4ak	145	14	patients	patient	NNS
cord-018834-4ligp4ak	145	15	.	.	.
cord-018834-4ligp4ak	146	1	HSA	HSA	NNP
cord-018834-4ligp4ak	146	2	levels	level	NNS
cord-018834-4ligp4ak	147	1	<	<	XX
cord-018834-4ligp4ak	147	2	20	20	CD
cord-018834-4ligp4ak	147	3	g	g	NN
cord-018834-4ligp4ak	147	4	/	/	SYM
cord-018834-4ligp4ak	147	5	L	L	NNP
cord-018834-4ligp4ak	147	6	were	be	VBD
cord-018834-4ligp4ak	147	7	associated	associate	VBN
cord-018834-4ligp4ak	147	8	with	with	IN
cord-018834-4ligp4ak	147	9	higher	high	JJR
cord-018834-4ligp4ak	147	10	mortality	mortality	NN
cord-018834-4ligp4ak	147	11	risk	risk	NN
cord-018834-4ligp4ak	147	12	in	in	IN
cord-018834-4ligp4ak	147	13	burn	burn	NN
cord-018834-4ligp4ak	147	14	patients	patient	NNS
cord-018834-4ligp4ak	147	15	with	with	IN
cord-018834-4ligp4ak	147	16	84	84	CD
cord-018834-4ligp4ak	147	17	%	%	NN
cord-018834-4ligp4ak	147	18	sensitivity	sensitivity	NN
cord-018834-4ligp4ak	147	19	and	and	CC
cord-018834-4ligp4ak	147	20	83	83	CD
cord-018834-4ligp4ak	147	21	%	%	NN
cord-018834-4ligp4ak	147	22	specifi	specifi	NN
cord-018834-4ligp4ak	147	23	city	city	NN
cord-018834-4ligp4ak	147	24	[	[	-LRB-
cord-018834-4ligp4ak	147	25	31	31	CD
cord-018834-4ligp4ak	147	26	]	]	-RRB-
cord-018834-4ligp4ak	147	27	.	.	.
cord-018834-4ligp4ak	148	1	In	in	IN
cord-018834-4ligp4ak	148	2	surgical	surgical	JJ
cord-018834-4ligp4ak	148	3	septic	septic	JJ
cord-018834-4ligp4ak	148	4	patients	patient	NNS
cord-018834-4ligp4ak	148	5	,	,	,
cord-018834-4ligp4ak	148	6	every	every	DT
cord-018834-4ligp4ak	148	7	1	1	CD
cord-018834-4ligp4ak	148	8	g	g	NN
cord-018834-4ligp4ak	148	9	/	/	SYM
cord-018834-4ligp4ak	148	10	L	L	NNP
cord-018834-4ligp4ak	148	11	decrease	decrease	NN
cord-018834-4ligp4ak	148	12	in	in	IN
cord-018834-4ligp4ak	148	13	albumin	albumin	NN
cord-018834-4ligp4ak	148	14	below	below	IN
cord-018834-4ligp4ak	148	15	23	23	CD
cord-018834-4ligp4ak	148	16	g	g	NNP
cord-018834-4ligp4ak	148	17	/	/	SYM
cord-018834-4ligp4ak	148	18	L	L	NNP
cord-018834-4ligp4ak	148	19	was	be	VBD
cord-018834-4ligp4ak	148	20	associated	associate	VBN
cord-018834-4ligp4ak	148	21	with	with	IN
cord-018834-4ligp4ak	148	22	a	a	DT
cord-018834-4ligp4ak	148	23	19.4	19.4	CD
cord-018834-4ligp4ak	148	24	%	%	NN
cord-018834-4ligp4ak	148	25	increase	increase	NN
cord-018834-4ligp4ak	148	26	in	in	IN
cord-018834-4ligp4ak	148	27	hospital	hospital	NN
cord-018834-4ligp4ak	148	28	mortality	mortality	NN
cord-018834-4ligp4ak	148	29	and	and	CC
cord-018834-4ligp4ak	148	30	28.7	28.7	CD
cord-018834-4ligp4ak	148	31	%	%	NN
cord-018834-4ligp4ak	148	32	increase	increase	NN
cord-018834-4ligp4ak	148	33	in	in	IN
cord-018834-4ligp4ak	148	34	the	the	DT
cord-018834-4ligp4ak	148	35	incidence	incidence	NN
cord-018834-4ligp4ak	148	36	of	of	IN
cord-018834-4ligp4ak	148	37	multiple	multiple	JJ
cord-018834-4ligp4ak	148	38	organ	organ	NN
cord-018834-4ligp4ak	148	39	failure	failure	NN
cord-018834-4ligp4ak	148	40	[	[	-LRB-
cord-018834-4ligp4ak	148	41	32	32	CD
cord-018834-4ligp4ak	148	42	]	]	-RRB-
cord-018834-4ligp4ak	148	43	.	.	.
cord-018834-4ligp4ak	149	1	Moreover	moreover	RB
cord-018834-4ligp4ak	149	2	,	,	,
cord-018834-4ligp4ak	149	3	in	in	IN
cord-018834-4ligp4ak	149	4	a	a	DT
cord-018834-4ligp4ak	149	5	meta	meta	JJ
cord-018834-4ligp4ak	149	6	-	-	HYPH
cord-018834-4ligp4ak	149	7	analysis	analysis	NN
cord-018834-4ligp4ak	149	8	of	of	IN
cord-018834-4ligp4ak	149	9	90	90	CD
cord-018834-4ligp4ak	149	10	cohort	cohort	NN
cord-018834-4ligp4ak	149	11	studies	study	NNS
cord-018834-4ligp4ak	149	12	that	that	WDT
cord-018834-4ligp4ak	149	13	evaluated	evaluate	VBD
cord-018834-4ligp4ak	149	14	hypoalbuminemia	hypoalbuminemia	NN
cord-018834-4ligp4ak	149	15	as	as	IN
cord-018834-4ligp4ak	149	16	a	a	DT
cord-018834-4ligp4ak	149	17	prognostic	prognostic	JJ
cord-018834-4ligp4ak	149	18	biomarker	biomarker	NN
cord-018834-4ligp4ak	149	19	in	in	IN
cord-018834-4ligp4ak	149	20	acutely	acutely	RB
cord-018834-4ligp4ak	149	21	ill	ill	JJ
cord-018834-4ligp4ak	149	22	patients	patient	NNS
cord-018834-4ligp4ak	149	23	,	,	,
cord-018834-4ligp4ak	149	24	each	each	DT
cord-018834-4ligp4ak	149	25	10	10	CD
cord-018834-4ligp4ak	149	26	g	g	NN
cord-018834-4ligp4ak	149	27	/	/	SYM
cord-018834-4ligp4ak	149	28	L	l	NN
cord-018834-4ligp4ak	149	29	in	in	IN
cord-018834-4ligp4ak	149	30	serum	serum	NN
cord-018834-4ligp4ak	149	31	albumin	albumin	NN
cord-018834-4ligp4ak	149	32	was	be	VBD
cord-018834-4ligp4ak	149	33	associated	associate	VBN
cord-018834-4ligp4ak	149	34	with	with	IN
cord-018834-4ligp4ak	149	35	a	a	DT
cord-018834-4ligp4ak	149	36	137	137	CD
cord-018834-4ligp4ak	149	37	%	%	NN
cord-018834-4ligp4ak	149	38	increase	increase	NN
cord-018834-4ligp4ak	149	39	in	in	IN
cord-018834-4ligp4ak	149	40	morbidity	morbidity	NN
cord-018834-4ligp4ak	149	41	,	,	,
cord-018834-4ligp4ak	149	42	and	and	CC
cord-018834-4ligp4ak	149	43	a	a	DT
cord-018834-4ligp4ak	149	44	71	71	CD
cord-018834-4ligp4ak	149	45	%	%	NN
cord-018834-4ligp4ak	149	46	increase	increase	NN
cord-018834-4ligp4ak	149	47	in	in	IN
cord-018834-4ligp4ak	149	48	length	length	NN
cord-018834-4ligp4ak	149	49	of	of	IN
cord-018834-4ligp4ak	149	50	hospital	hospital	NN
cord-018834-4ligp4ak	149	51	stay	stay	NN
cord-018834-4ligp4ak	149	52	[	[	-LRB-
cord-018834-4ligp4ak	149	53	33	33	CD
cord-018834-4ligp4ak	149	54	]	]	-RRB-
cord-018834-4ligp4ak	149	55	.	.	.
cord-018834-4ligp4ak	150	1	Preoperative	Preoperative	NNP
cord-018834-4ligp4ak	150	2	low	low	JJ
cord-018834-4ligp4ak	150	3	serum	serum	NN
cord-018834-4ligp4ak	150	4	albumin	albumin	NN
cord-018834-4ligp4ak	150	5	(	(	-LRB-
cord-018834-4ligp4ak	150	6	<	<	NNP
cord-018834-4ligp4ak	150	7	4.0	4.0	CD
cord-018834-4ligp4ak	150	8	g	g	NN
cord-018834-4ligp4ak	150	9	/	/	SYM
cord-018834-4ligp4ak	150	10	dl	dl	NN
cord-018834-4ligp4ak	150	11	)	)	-RRB-
cord-018834-4ligp4ak	150	12	was	be	VBD
cord-018834-4ligp4ak	150	13	shown	show	VBN
cord-018834-4ligp4ak	150	14	to	to	TO
cord-018834-4ligp4ak	150	15	be	be	VB
cord-018834-4ligp4ak	150	16	an	an	DT
cord-018834-4ligp4ak	150	17	independent	independent	JJ
cord-018834-4ligp4ak	150	18	risk	risk	NN
cord-018834-4ligp4ak	150	19	factor	factor	NN
cord-018834-4ligp4ak	150	20	for	for	IN
cord-018834-4ligp4ak	150	21	acute	acute	JJ
cord-018834-4ligp4ak	150	22	kidney	kidney	NN
cord-018834-4ligp4ak	150	23	injury	injury	NN
cord-018834-4ligp4ak	150	24	(	(	-LRB-
cord-018834-4ligp4ak	150	25	AKI	AKI	NNP
cord-018834-4ligp4ak	150	26	)	)	-RRB-
cord-018834-4ligp4ak	150	27	following	follow	VBG
cord-018834-4ligp4ak	150	28	off	off	IN
cord-018834-4ligp4ak	150	29	-	-	HYPH
cord-018834-4ligp4ak	150	30	pump	pump	NN
cord-018834-4ligp4ak	150	31	coronary	coronary	JJ
cord-018834-4ligp4ak	150	32	artery	artery	NN
cord-018834-4ligp4ak	150	33	bypass	bypass	NN
cord-018834-4ligp4ak	150	34	surgery	surgery	NN
cord-018834-4ligp4ak	150	35	(	(	-LRB-
cord-018834-4ligp4ak	150	36	OPCAB	OPCAB	NNP
cord-018834-4ligp4ak	150	37	)	)	-RRB-
cord-018834-4ligp4ak	150	38	.	.	.
cord-018834-4ligp4ak	151	1	AKI	AKI	NNP
cord-018834-4ligp4ak	151	2	was	be	VBD
cord-018834-4ligp4ak	151	3	associated	associate	VBN
cord-018834-4ligp4ak	151	4	with	with	IN
cord-018834-4ligp4ak	151	5	prolonged	prolonged	JJ
cord-018834-4ligp4ak	151	6	stay	stay	NN
cord-018834-4ligp4ak	151	7	in	in	IN
cord-018834-4ligp4ak	151	8	the	the	DT
cord-018834-4ligp4ak	151	9	intensive	intensive	JJ
cord-018834-4ligp4ak	151	10	care	care	NN
cord-018834-4ligp4ak	151	11	unit	unit	NN
cord-018834-4ligp4ak	151	12	(	(	-LRB-
cord-018834-4ligp4ak	151	13	ICU	ICU	NNP
cord-018834-4ligp4ak	151	14	)	)	-RRB-
cord-018834-4ligp4ak	151	15	and	and	CC
cord-018834-4ligp4ak	151	16	hospital	hospital	NN
cord-018834-4ligp4ak	151	17	and	and	CC
cord-018834-4ligp4ak	151	18	a	a	DT
cord-018834-4ligp4ak	151	19	high	high	JJ
cord-018834-4ligp4ak	151	20	mortality	mortality	NN
cord-018834-4ligp4ak	151	21	rate	rate	NN
cord-018834-4ligp4ak	151	22	[	[	-LRB-
cord-018834-4ligp4ak	151	23	34	34	CD
cord-018834-4ligp4ak	151	24	]	]	-RRB-
cord-018834-4ligp4ak	151	25	.	.	.
cord-018834-4ligp4ak	152	1	HSA	HSA	NNP
cord-018834-4ligp4ak	152	2	circulates	circulate	VBZ
cord-018834-4ligp4ak	152	3	from	from	IN
cord-018834-4ligp4ak	152	4	the	the	DT
cord-018834-4ligp4ak	152	5	blood	blood	NN
cord-018834-4ligp4ak	152	6	across	across	IN
cord-018834-4ligp4ak	152	7	the	the	DT
cord-018834-4ligp4ak	152	8	capillary	capillary	JJ
cord-018834-4ligp4ak	152	9	wall	wall	NN
cord-018834-4ligp4ak	152	10	into	into	IN
cord-018834-4ligp4ak	152	11	the	the	DT
cord-018834-4ligp4ak	152	12	interstitial	interstitial	JJ
cord-018834-4ligp4ak	152	13	compartments	compartment	NNS
cord-018834-4ligp4ak	152	14	,	,	,
cord-018834-4ligp4ak	152	15	including	include	VBG
cord-018834-4ligp4ak	152	16	cerebrospinal	cerebrospinal	JJ
cord-018834-4ligp4ak	152	17	fl	fl	NNP
cord-018834-4ligp4ak	152	18	uid	uid	NN
cord-018834-4ligp4ak	152	19	,	,	,
cord-018834-4ligp4ak	152	20	and	and	CC
cord-018834-4ligp4ak	152	21	returns	return	VBZ
cord-018834-4ligp4ak	152	22	to	to	IN
cord-018834-4ligp4ak	152	23	the	the	DT
cord-018834-4ligp4ak	152	24	blood	blood	NN
cord-018834-4ligp4ak	152	25	through	through	IN
cord-018834-4ligp4ak	152	26	the	the	DT
cord-018834-4ligp4ak	152	27	lymphatic	lymphatic	JJ
cord-018834-4ligp4ak	152	28	system	system	NN
cord-018834-4ligp4ak	152	29	with	with	IN
cord-018834-4ligp4ak	152	30	a	a	DT
cord-018834-4ligp4ak	152	31	circulation	circulation	NN
cord-018834-4ligp4ak	152	32	half	half	JJ
cord-018834-4ligp4ak	152	33	-	-	HYPH
cord-018834-4ligp4ak	152	34	life	life	NN
cord-018834-4ligp4ak	152	35	of	of	IN
cord-018834-4ligp4ak	152	36	approximately	approximately	RB
cord-018834-4ligp4ak	152	37	16	16	CD
cord-018834-4ligp4ak	152	38	h.	h.	NN
cord-018834-4ligp4ak	153	1	The	the	DT
cord-018834-4ligp4ak	153	2	movement	movement	NN
cord-018834-4ligp4ak	153	3	of	of	IN
cord-018834-4ligp4ak	153	4	HSA	HSA	NNP
cord-018834-4ligp4ak	153	5	across	across	IN
cord-018834-4ligp4ak	153	6	the	the	DT
cord-018834-4ligp4ak	153	7	capillary	capillary	JJ
cord-018834-4ligp4ak	153	8	wall	wall	NN
cord-018834-4ligp4ak	153	9	is	be	VBZ
cord-018834-4ligp4ak	153	10	defi	defi	NNP
cord-018834-4ligp4ak	153	11	ned	ned	NNP
cord-018834-4ligp4ak	153	12	as	as	IN
cord-018834-4ligp4ak	153	13	the	the	DT
cord-018834-4ligp4ak	153	14	transcapillary	transcapillary	JJ
cord-018834-4ligp4ak	153	15	escape	escape	NN
cord-018834-4ligp4ak	153	16	rate	rate	NN
cord-018834-4ligp4ak	153	17	(	(	-LRB-
cord-018834-4ligp4ak	153	18	5	5	CD
cord-018834-4ligp4ak	153	19	%	%	NN
cord-018834-4ligp4ak	153	20	per	per	IN
cord-018834-4ligp4ak	153	21	hour	hour	NN
cord-018834-4ligp4ak	153	22	)	)	-RRB-
cord-018834-4ligp4ak	153	23	,	,	,
cord-018834-4ligp4ak	153	24	which	which	WDT
cord-018834-4ligp4ak	153	25	indicates	indicate	VBZ
cord-018834-4ligp4ak	153	26	the	the	DT
cord-018834-4ligp4ak	153	27	percentage	percentage	NN
cord-018834-4ligp4ak	153	28	of	of	IN
cord-018834-4ligp4ak	153	29	intravascular	intravascular	JJ
cord-018834-4ligp4ak	153	30	HSA	HSA	NNP
cord-018834-4ligp4ak	153	31	leaving	leave	VBG
cord-018834-4ligp4ak	153	32	the	the	DT
cord-018834-4ligp4ak	153	33	intravascular	intravascular	JJ
cord-018834-4ligp4ak	153	34	compartment	compartment	NN
cord-018834-4ligp4ak	153	35	per	per	IN
cord-018834-4ligp4ak	153	36	hour	hour	NN
cord-018834-4ligp4ak	153	37	[	[	-LRB-
cord-018834-4ligp4ak	153	38	13	13	CD
cord-018834-4ligp4ak	153	39	]	]	-RRB-
cord-018834-4ligp4ak	153	40	.	.	.
cord-018834-4ligp4ak	154	1	In	in	IN
cord-018834-4ligp4ak	154	2	its	-PRON-	PRP$
cord-018834-4ligp4ak	154	3	long	long	JJ
cord-018834-4ligp4ak	154	4	half	half	JJ
cord-018834-4ligp4ak	154	5	-	-	HYPH
cord-018834-4ligp4ak	154	6	life	life	NN
cord-018834-4ligp4ak	154	7	of	of	IN
cord-018834-4ligp4ak	154	8	~2	~2	NNP
cord-018834-4ligp4ak	154	9	-	-	SYM
cord-018834-4ligp4ak	154	10	3	3	CD
cord-018834-4ligp4ak	154	11	weeks	week	NNS
cord-018834-4ligp4ak	154	12	,	,	,
cord-018834-4ligp4ak	154	13	1	1	CD
cord-018834-4ligp4ak	154	14	HSA	HSA	NNP
cord-018834-4ligp4ak	154	15	molecule	molecule	NN
cord-018834-4ligp4ak	154	16	could	could	MD
cord-018834-4ligp4ak	154	17	make	make	VB
cord-018834-4ligp4ak	154	18	about	about	IN
cord-018834-4ligp4ak	154	19	15,000	15,000	CD
cord-018834-4ligp4ak	154	20	passes	pass	NNS
cord-018834-4ligp4ak	154	21	through	through	IN
cord-018834-4ligp4ak	154	22	the	the	DT
cord-018834-4ligp4ak	154	23	circulation	circulation	NN
cord-018834-4ligp4ak	154	24	.	.	.
cord-018834-4ligp4ak	155	1	HSA	HSA	NNP
cord-018834-4ligp4ak	155	2	is	be	VBZ
cord-018834-4ligp4ak	155	3	mainly	mainly	RB
cord-018834-4ligp4ak	155	4	synthesized	synthesize	VBN
cord-018834-4ligp4ak	155	5	in	in	IN
cord-018834-4ligp4ak	155	6	the	the	DT
cord-018834-4ligp4ak	155	7	liver	liver	NN
cord-018834-4ligp4ak	155	8	.	.	.
cord-018834-4ligp4ak	156	1	In	in	IN
cord-018834-4ligp4ak	156	2	healthy	healthy	JJ
cord-018834-4ligp4ak	156	3	young	young	JJ
cord-018834-4ligp4ak	156	4	adults	adult	NNS
cord-018834-4ligp4ak	156	5	,	,	,
cord-018834-4ligp4ak	156	6	about	about	RB
cord-018834-4ligp4ak	156	7	12	12	CD
cord-018834-4ligp4ak	156	8	-	-	SYM
cord-018834-4ligp4ak	156	9	25	25	CD
cord-018834-4ligp4ak	156	10	g	g	NN
cord-018834-4ligp4ak	156	11	of	of	IN
cord-018834-4ligp4ak	156	12	HSA	HSA	NNP
cord-018834-4ligp4ak	156	13	per	per	IN
cord-018834-4ligp4ak	156	14	day	day	NN
cord-018834-4ligp4ak	156	15	is	be	VBZ
cord-018834-4ligp4ak	156	16	synthesized	synthesize	VBN
cord-018834-4ligp4ak	156	17	in	in	IN
cord-018834-4ligp4ak	156	18	polysomes	polysome	NNS
cord-018834-4ligp4ak	156	19	bound	bind	VBN
cord-018834-4ligp4ak	156	20	to	to	TO
cord-018834-4ligp4ak	156	21	endoplasmic	endoplasmic	VB
cord-018834-4ligp4ak	156	22	reticulum	reticulum	NN
cord-018834-4ligp4ak	156	23	of	of	IN
cord-018834-4ligp4ak	156	24	hepatocytes	hepatocyte	NNS
cord-018834-4ligp4ak	156	25	.	.	.
cord-018834-4ligp4ak	157	1	HSA	HSA	NNP
cord-018834-4ligp4ak	157	2	is	be	VBZ
cord-018834-4ligp4ak	157	3	not	not	RB
cord-018834-4ligp4ak	157	4	stored	store	VBN
cord-018834-4ligp4ak	157	5	hepatically	hepatically	RB
cord-018834-4ligp4ak	157	6	and	and	CC
cord-018834-4ligp4ak	157	7	there	there	EX
cord-018834-4ligp4ak	157	8	is	be	VBZ
cord-018834-4ligp4ak	157	9	therefore	therefore	RB
cord-018834-4ligp4ak	157	10	no	no	DT
cord-018834-4ligp4ak	157	11	reserve	reserve	NN
cord-018834-4ligp4ak	157	12	for	for	IN
cord-018834-4ligp4ak	157	13	release	release	NN
cord-018834-4ligp4ak	157	14	on	on	IN
cord-018834-4ligp4ak	157	15	demand	demand	NN
cord-018834-4ligp4ak	157	16	[	[	-LRB-
cord-018834-4ligp4ak	157	17	30	30	CD
cord-018834-4ligp4ak	157	18	]	]	-RRB-
cord-018834-4ligp4ak	157	19	.	.	.
cord-018834-4ligp4ak	158	1	Under	under	IN
cord-018834-4ligp4ak	158	2	physiological	physiological	JJ
cord-018834-4ligp4ak	158	3	circumstances	circumstance	NNS
cord-018834-4ligp4ak	158	4	,	,	,
cord-018834-4ligp4ak	158	5	only	only	RB
cord-018834-4ligp4ak	158	6	20	20	CD
cord-018834-4ligp4ak	158	7	-	-	SYM
cord-018834-4ligp4ak	158	8	30	30	CD
cord-018834-4ligp4ak	158	9	%	%	NN
cord-018834-4ligp4ak	158	10	of	of	IN
cord-018834-4ligp4ak	158	11	hepatocytes	hepatocyte	NNS
cord-018834-4ligp4ak	158	12	produce	produce	VBP
cord-018834-4ligp4ak	158	13	HSA	HSA	NNP
cord-018834-4ligp4ak	158	14	and	and	CC
cord-018834-4ligp4ak	158	15	its	-PRON-	PRP$
cord-018834-4ligp4ak	158	16	synthesis	synthesis	NN
cord-018834-4ligp4ak	158	17	can	can	MD
cord-018834-4ligp4ak	158	18	be	be	VB
cord-018834-4ligp4ak	158	19	increased	increase	VBN
cord-018834-4ligp4ak	158	20	up	up	IN
cord-018834-4ligp4ak	158	21	to	to	IN
cord-018834-4ligp4ak	158	22	200	200	CD
cord-018834-4ligp4ak	158	23	-	-	SYM
cord-018834-4ligp4ak	158	24	300	300	CD
cord-018834-4ligp4ak	158	25	%	%	NN
cord-018834-4ligp4ak	158	26	on	on	IN
cord-018834-4ligp4ak	158	27	demand	demand	NN
cord-018834-4ligp4ak	158	28	.	.	.
cord-018834-4ligp4ak	159	1	HSA	HSA	NNP
cord-018834-4ligp4ak	159	2	synthesis	synthesis	NN
cord-018834-4ligp4ak	159	3	is	be	VBZ
cord-018834-4ligp4ak	159	4	regulated	regulate	VBN
cord-018834-4ligp4ak	159	5	by	by	IN
cord-018834-4ligp4ak	159	6	colloid	colloid	NN
cord-018834-4ligp4ak	159	7	osmotic	osmotic	JJ
cord-018834-4ligp4ak	159	8	pressure	pressure	NN
cord-018834-4ligp4ak	159	9	and	and	CC
cord-018834-4ligp4ak	159	10	the	the	DT
cord-018834-4ligp4ak	159	11	osmolality	osmolality	NN
cord-018834-4ligp4ak	159	12	of	of	IN
cord-018834-4ligp4ak	159	13	the	the	DT
cord-018834-4ligp4ak	159	14	interstitial	interstitial	JJ
cord-018834-4ligp4ak	159	15	liquid	liquid	NN
cord-018834-4ligp4ak	159	16	around	around	IN
cord-018834-4ligp4ak	159	17	the	the	DT
cord-018834-4ligp4ak	159	18	hepatocytes	hepatocyte	NNS
cord-018834-4ligp4ak	159	19	.	.	.
cord-018834-4ligp4ak	160	1	Insulin	insulin	NN
cord-018834-4ligp4ak	160	2	plays	play	VBZ
cord-018834-4ligp4ak	160	3	an	an	DT
cord-018834-4ligp4ak	160	4	important	important	JJ
cord-018834-4ligp4ak	160	5	role	role	NN
cord-018834-4ligp4ak	160	6	in	in	IN
cord-018834-4ligp4ak	160	7	stimulating	stimulate	VBG
cord-018834-4ligp4ak	160	8	HSA	HSA	NNP
cord-018834-4ligp4ak	160	9	synthesis	synthesis	NN
cord-018834-4ligp4ak	160	10	;	;	:
cord-018834-4ligp4ak	160	11	therefore	therefore	RB
cord-018834-4ligp4ak	160	12	,	,	,
cord-018834-4ligp4ak	160	13	diabetic	diabetic	JJ
cord-018834-4ligp4ak	160	14	patients	patient	NNS
cord-018834-4ligp4ak	160	15	could	could	MD
cord-018834-4ligp4ak	160	16	suffer	suffer	VB
cord-018834-4ligp4ak	160	17	hypoalbuminemia	hypoalbuminemia	NN
cord-018834-4ligp4ak	160	18	.	.	.
cord-018834-4ligp4ak	161	1	Estrogens	estrogen	NNS
cord-018834-4ligp4ak	161	2	do	do	VBP
cord-018834-4ligp4ak	161	3	not	not	RB
cord-018834-4ligp4ak	161	4	affect	affect	VB
cord-018834-4ligp4ak	161	5	HSA	HSA	NNP
cord-018834-4ligp4ak	161	6	transcription	transcription	NN
cord-018834-4ligp4ak	161	7	,	,	,
cord-018834-4ligp4ak	161	8	but	but	CC
cord-018834-4ligp4ak	161	9	act	act	VB
cord-018834-4ligp4ak	161	10	by	by	IN
cord-018834-4ligp4ak	161	11	modifying	modify	VBG
cord-018834-4ligp4ak	161	12	the	the	DT
cord-018834-4ligp4ak	161	13	stability	stability	NN
cord-018834-4ligp4ak	161	14	of	of	IN
cord-018834-4ligp4ak	161	15	the	the	DT
cord-018834-4ligp4ak	161	16	HSA	HSA	NNP
cord-018834-4ligp4ak	161	17	mRNA	mRNA	NNP
cord-018834-4ligp4ak	161	18	.	.	.
cord-018834-4ligp4ak	162	1	HSA	HSA	NNP
cord-018834-4ligp4ak	162	2	synthesis	synthesis	NN
cord-018834-4ligp4ak	162	3	can	can	MD
cord-018834-4ligp4ak	162	4	be	be	VB
cord-018834-4ligp4ak	162	5	enhanced	enhance	VBN
cord-018834-4ligp4ak	162	6	by	by	IN
cord-018834-4ligp4ak	162	7	corticosteroids	corticosteroid	NNS
cord-018834-4ligp4ak	162	8	,	,	,
cord-018834-4ligp4ak	162	9	insulin	insulin	NN
cord-018834-4ligp4ak	162	10	,	,	,
cord-018834-4ligp4ak	162	11	and	and	CC
cord-018834-4ligp4ak	162	12	amino	amino	JJ
cord-018834-4ligp4ak	162	13	acids	acid	NNS
cord-018834-4ligp4ak	162	14	administration	administration	NN
cord-018834-4ligp4ak	162	15	.	.	.
cord-018834-4ligp4ak	163	1	HSA	HSA	NNP
cord-018834-4ligp4ak	163	2	synthesis	synthesis	NN
cord-018834-4ligp4ak	163	3	can	can	MD
cord-018834-4ligp4ak	163	4	be	be	VB
cord-018834-4ligp4ak	163	5	rate	rate	NN
cord-018834-4ligp4ak	163	6	-	-	HYPH
cord-018834-4ligp4ak	163	7	limited	limit	VBN
cord-018834-4ligp4ak	163	8	by	by	IN
cord-018834-4ligp4ak	163	9	amino	amino	NN
cord-018834-4ligp4ak	163	10	acid	acid	NN
cord-018834-4ligp4ak	163	11	defi	defi	NNP
cord-018834-4ligp4ak	163	12	ciencies	ciencie	NNS
cord-018834-4ligp4ak	163	13	,	,	,
cord-018834-4ligp4ak	163	14	but	but	CC
cord-018834-4ligp4ak	163	15	these	these	DT
cord-018834-4ligp4ak	163	16	are	be	VBP
cord-018834-4ligp4ak	163	17	rarely	rarely	RB
cord-018834-4ligp4ak	163	18	seen	see	VBN
cord-018834-4ligp4ak	163	19	clinically	clinically	RB
cord-018834-4ligp4ak	163	20	,	,	,
cord-018834-4ligp4ak	163	21	except	except	IN
cord-018834-4ligp4ak	163	22	in	in	IN
cord-018834-4ligp4ak	163	23	states	state	NNS
cord-018834-4ligp4ak	163	24	of	of	IN
cord-018834-4ligp4ak	163	25	extreme	extreme	JJ
cord-018834-4ligp4ak	163	26	starvation	starvation	NN
cord-018834-4ligp4ak	163	27	and	and	CC
cord-018834-4ligp4ak	163	28	malnutrition	malnutrition	NN
cord-018834-4ligp4ak	163	29	[	[	-LRB-
cord-018834-4ligp4ak	163	30	30	30	CD
cord-018834-4ligp4ak	163	31	]	]	-RRB-
cord-018834-4ligp4ak	163	32	.	.	.
cord-018834-4ligp4ak	164	1	In	in	IN
cord-018834-4ligp4ak	164	2	acutephase	acutephase	NN
cord-018834-4ligp4ak	164	3	reactions	reaction	NNS
cord-018834-4ligp4ak	164	4	,	,	,
cord-018834-4ligp4ak	164	5	such	such	JJ
cord-018834-4ligp4ak	164	6	as	as	IN
cord-018834-4ligp4ak	164	7	in	in	IN
cord-018834-4ligp4ak	164	8	trauma	trauma	NN
cord-018834-4ligp4ak	164	9	and	and	CC
cord-018834-4ligp4ak	164	10	the	the	DT
cord-018834-4ligp4ak	164	11	perioperative	perioperative	JJ
cord-018834-4ligp4ak	164	12	period	period	NN
cord-018834-4ligp4ak	164	13	,	,	,
cord-018834-4ligp4ak	164	14	the	the	DT
cord-018834-4ligp4ak	164	15	synthesis	synthesis	NN
cord-018834-4ligp4ak	164	16	of	of	IN
cord-018834-4ligp4ak	164	17	HSA	HSA	NNP
cord-018834-4ligp4ak	164	18	is	be	VBZ
cord-018834-4ligp4ak	164	19	depressed	depress	VBN
cord-018834-4ligp4ak	164	20	by	by	IN
cord-018834-4ligp4ak	164	21	hepatic	hepatic	JJ
cord-018834-4ligp4ak	164	22	cytokines	cytokine	NNS
cord-018834-4ligp4ak	164	23	such	such	JJ
cord-018834-4ligp4ak	164	24	as	as	IN
cord-018834-4ligp4ak	164	25	interleukin-6	interleukin-6	NNP
cord-018834-4ligp4ak	164	26	and	and	CC
cord-018834-4ligp4ak	164	27	tumor	tumor	NN
cord-018834-4ligp4ak	164	28	necrosis	necrosis	NN
cord-018834-4ligp4ak	164	29	factor	factor	NN
cord-018834-4ligp4ak	164	30	-	-	HYPH
cord-018834-4ligp4ak	164	31	α(alpha	α(alpha	NN
cord-018834-4ligp4ak	164	32	)	)	-RRB-
cord-018834-4ligp4ak	164	33	.	.	.
cord-018834-4ligp4ak	165	1	Immunoglobulin	immunoglobulin	NN
cord-018834-4ligp4ak	165	2	G	G	NNP
cord-018834-4ligp4ak	165	3	(	(	-LRB-
cord-018834-4ligp4ak	165	4	IgG	IgG	NNP
cord-018834-4ligp4ak	165	5	)	)	-RRB-
cord-018834-4ligp4ak	165	6	and	and	CC
cord-018834-4ligp4ak	165	7	albumin	albumin	NN
cord-018834-4ligp4ak	165	8	,	,	,
cord-018834-4ligp4ak	165	9	despite	despite	IN
cord-018834-4ligp4ak	165	10	their	-PRON-	PRP$
cord-018834-4ligp4ak	165	11	disparate	disparate	JJ
cord-018834-4ligp4ak	165	12	forms	form	NNS
cord-018834-4ligp4ak	165	13	and	and	CC
cord-018834-4ligp4ak	165	14	functions	function	NNS
cord-018834-4ligp4ak	165	15	,	,	,
cord-018834-4ligp4ak	165	16	have	have	VBP
cord-018834-4ligp4ak	165	17	long	long	RB
cord-018834-4ligp4ak	165	18	been	be	VBN
cord-018834-4ligp4ak	165	19	known	know	VBN
cord-018834-4ligp4ak	165	20	to	to	TO
cord-018834-4ligp4ak	165	21	share	share	VB
cord-018834-4ligp4ak	165	22	two	two	CD
cord-018834-4ligp4ak	165	23	unique	unique	JJ
cord-018834-4ligp4ak	165	24	characteristics	characteristic	NNS
cord-018834-4ligp4ak	165	25	,	,	,
cord-018834-4ligp4ak	165	26	namely	namely	RB
cord-018834-4ligp4ak	165	27	,	,	,
cord-018834-4ligp4ak	165	28	their	-PRON-	PRP$
cord-018834-4ligp4ak	165	29	lengthy	lengthy	JJ
cord-018834-4ligp4ak	165	30	life	life	NN
cord-018834-4ligp4ak	165	31	spans	span	NNS
cord-018834-4ligp4ak	165	32	and	and	CC
cord-018834-4ligp4ak	165	33	inverse	inverse	JJ
cord-018834-4ligp4ak	165	34	relationship	relationship	NN
cord-018834-4ligp4ak	165	35	between	between	IN
cord-018834-4ligp4ak	165	36	their	-PRON-	PRP$
cord-018834-4ligp4ak	165	37	serum	serum	NN
cord-018834-4ligp4ak	165	38	concentrations	concentration	NNS
cord-018834-4ligp4ak	165	39	and	and	CC
cord-018834-4ligp4ak	165	40	half	half	RB
cord-018834-4ligp4ak	165	41	-	-	HYPH
cord-018834-4ligp4ak	165	42	lives	life	NNS
cord-018834-4ligp4ak	165	43	.	.	.
cord-018834-4ligp4ak	166	1	The	the	DT
cord-018834-4ligp4ak	166	2	long	long	JJ
cord-018834-4ligp4ak	166	3	half	half	RB
cord-018834-4ligp4ak	166	4	-	-	HYPH
cord-018834-4ligp4ak	166	5	lives	life	NNS
cord-018834-4ligp4ak	166	6	are	be	VBP
cord-018834-4ligp4ak	166	7	attributed	attribute	VBN
cord-018834-4ligp4ak	166	8	to	to	IN
cord-018834-4ligp4ak	166	9	the	the	DT
cord-018834-4ligp4ak	166	10	effi	effi	NNP
cord-018834-4ligp4ak	166	11	cient	cient	NNP
cord-018834-4ligp4ak	166	12	receptor	receptor	NN
cord-018834-4ligp4ak	166	13	-	-	HYPH
cord-018834-4ligp4ak	166	14	mediated	mediate	VBN
cord-018834-4ligp4ak	166	15	recycling	recycling	NN
cord-018834-4ligp4ak	166	16	pathway	pathway	NN
cord-018834-4ligp4ak	166	17	involving	involve	VBG
cord-018834-4ligp4ak	166	18	the	the	DT
cord-018834-4ligp4ak	166	19	neonatal	neonatal	JJ
cord-018834-4ligp4ak	166	20	Fc	Fc	NNP
cord-018834-4ligp4ak	166	21	receptor	receptor	NN
cord-018834-4ligp4ak	166	22	(	(	-LRB-
cord-018834-4ligp4ak	166	23	FcRn	FcRn	NNP
cord-018834-4ligp4ak	166	24	)	)	-RRB-
cord-018834-4ligp4ak	166	25	.	.	.
cord-018834-4ligp4ak	167	1	FcRn	FcRn	NNP
cord-018834-4ligp4ak	167	2	is	be	VBZ
cord-018834-4ligp4ak	167	3	a	a	DT
cord-018834-4ligp4ak	167	4	heterodimer	heterodimer	NN
cord-018834-4ligp4ak	167	5	of	of	IN
cord-018834-4ligp4ak	167	6	a	a	DT
cord-018834-4ligp4ak	167	7	nonclassical	nonclassical	JJ
cord-018834-4ligp4ak	167	8	major	major	JJ
cord-018834-4ligp4ak	167	9	histocompatibility	histocompatibility	NN
cord-018834-4ligp4ak	167	10	class	class	NN
cord-018834-4ligp4ak	167	11	I	i	NN
cord-018834-4ligp4ak	167	12	(	(	-LRB-
cord-018834-4ligp4ak	167	13	MHC	MHC	NNP
cord-018834-4ligp4ak	167	14	I	I	NNP
cord-018834-4ligp4ak	167	15	)	)	-RRB-
cord-018834-4ligp4ak	167	16	α(alpha)-chain	α(alpha)-chain	NNP
cord-018834-4ligp4ak	167	17	and	and	CC
cord-018834-4ligp4ak	167	18	β(beta	β(beta	$
cord-018834-4ligp4ak	167	19	)	)	-RRB-
cord-018834-4ligp4ak	167	20	2	2	CD
cord-018834-4ligp4ak	167	21	microglobulin	microglobulin	NN
cord-018834-4ligp4ak	167	22	(	(	-LRB-
cord-018834-4ligp4ak	167	23	β[beta	β[beta	NNP
cord-018834-4ligp4ak	167	24	]	]	-RRB-
cord-018834-4ligp4ak	167	25	2	2	CD
cord-018834-4ligp4ak	167	26	m	m	CD
cord-018834-4ligp4ak	167	27	)	)	-RRB-
cord-018834-4ligp4ak	167	28	that	that	WDT
cord-018834-4ligp4ak	167	29	binds	bind	VBZ
cord-018834-4ligp4ak	167	30	the	the	DT
cord-018834-4ligp4ak	167	31	two	two	CD
cord-018834-4ligp4ak	167	32	abundant	abundant	JJ
cord-018834-4ligp4ak	167	33	serum	serum	NN
cord-018834-4ligp4ak	167	34	proteins	protein	NNS
cord-018834-4ligp4ak	167	35	IgG	igg	NN
cord-018834-4ligp4ak	167	36	and	and	CC
cord-018834-4ligp4ak	167	37	albumin	albumin	NN
cord-018834-4ligp4ak	167	38	in	in	IN
cord-018834-4ligp4ak	167	39	the	the	DT
cord-018834-4ligp4ak	167	40	body	body	NN
cord-018834-4ligp4ak	167	41	.	.	.
cord-018834-4ligp4ak	168	1	FcRn	FcRn	NNP
cord-018834-4ligp4ak	168	2	binds	bind	VBZ
cord-018834-4ligp4ak	168	3	both	both	CC
cord-018834-4ligp4ak	168	4	IgG	igg	NN
cord-018834-4ligp4ak	168	5	and	and	CC
cord-018834-4ligp4ak	168	6	albumin	albumin	NN
cord-018834-4ligp4ak	168	7	simultaneously	simultaneously	RB
cord-018834-4ligp4ak	168	8	on	on	IN
cord-018834-4ligp4ak	168	9	the	the	DT
cord-018834-4ligp4ak	168	10	opposite	opposite	JJ
cord-018834-4ligp4ak	168	11	sides	side	NNS
cord-018834-4ligp4ak	168	12	of	of	IN
cord-018834-4ligp4ak	168	13	the	the	DT
cord-018834-4ligp4ak	168	14	receptor	receptor	NN
cord-018834-4ligp4ak	168	15	,	,	,
cord-018834-4ligp4ak	168	16	where	where	WRB
cord-018834-4ligp4ak	168	17	the	the	DT
cord-018834-4ligp4ak	168	18	net	net	JJ
cord-018834-4ligp4ak	168	19	transport	transport	NN
cord-018834-4ligp4ak	168	20	can	can	MD
cord-018834-4ligp4ak	168	21	be	be	VB
cord-018834-4ligp4ak	168	22	basolateral	basolateral	JJ
cord-018834-4ligp4ak	168	23	to	to	IN
cord-018834-4ligp4ak	168	24	apical	apical	JJ
cord-018834-4ligp4ak	168	25	,	,	,
cord-018834-4ligp4ak	168	26	apical	apical	JJ
cord-018834-4ligp4ak	168	27	to	to	IN
cord-018834-4ligp4ak	168	28	basolateral	basolateral	JJ
cord-018834-4ligp4ak	168	29	,	,	,
cord-018834-4ligp4ak	168	30	or	or	CC
cord-018834-4ligp4ak	168	31	apical	apical	JJ
cord-018834-4ligp4ak	168	32	to	to	IN
cord-018834-4ligp4ak	168	33	apical	apical	JJ
cord-018834-4ligp4ak	168	34	(	(	-LRB-
cord-018834-4ligp4ak	168	35	endothelial	endothelial	JJ
cord-018834-4ligp4ak	168	36	cells	cell	NNS
cord-018834-4ligp4ak	168	37	)	)	-RRB-
cord-018834-4ligp4ak	168	38	.	.	.
cord-018834-4ligp4ak	169	1	FcRn	FcRn	NNP
cord-018834-4ligp4ak	169	2	interacts	interact	VBZ
cord-018834-4ligp4ak	169	3	with	with	IN
cord-018834-4ligp4ak	169	4	IgG	igg	NN
cord-018834-4ligp4ak	169	5	and	and	CC
cord-018834-4ligp4ak	169	6	albumin	albumin	NN
cord-018834-4ligp4ak	169	7	in	in	IN
cord-018834-4ligp4ak	169	8	a	a	DT
cord-018834-4ligp4ak	169	9	strictly	strictly	RB
cord-018834-4ligp4ak	169	10	pH	ph	JJ
cord-018834-4ligp4ak	169	11	-	-	HYPH
cord-018834-4ligp4ak	169	12	dependent	dependent	JJ
cord-018834-4ligp4ak	169	13	manner	manner	NN
cord-018834-4ligp4ak	169	14	;	;	:
cord-018834-4ligp4ak	169	15	therefore	therefore	RB
cord-018834-4ligp4ak	169	16	,	,	,
cord-018834-4ligp4ak	169	17	it	-PRON-	PRP
cord-018834-4ligp4ak	169	18	binds	bind	VBZ
cord-018834-4ligp4ak	169	19	them	-PRON-	PRP
cord-018834-4ligp4ak	169	20	at	at	IN
cord-018834-4ligp4ak	169	21	acidic	acidic	JJ
cord-018834-4ligp4ak	169	22	pH	ph	NN
cord-018834-4ligp4ak	169	23	and	and	CC
cord-018834-4ligp4ak	169	24	not	not	RB
cord-018834-4ligp4ak	169	25	at	at	IN
cord-018834-4ligp4ak	169	26	physiological	physiological	JJ
cord-018834-4ligp4ak	169	27	pH.	ph.	NN
cord-018834-4ligp4ak	169	28	Pinocytosed	Pinocytosed	NNP
cord-018834-4ligp4ak	169	29	IgG	igg	NN
cord-018834-4ligp4ak	169	30	and	and	CC
cord-018834-4ligp4ak	169	31	albumin	albumin	NN
cord-018834-4ligp4ak	169	32	bound	bind	VBN
cord-018834-4ligp4ak	169	33	by	by	IN
cord-018834-4ligp4ak	169	34	the	the	DT
cord-018834-4ligp4ak	169	35	receptor	receptor	NN
cord-018834-4ligp4ak	169	36	within	within	IN
cord-018834-4ligp4ak	169	37	acidifi	acidifi	NNP
cord-018834-4ligp4ak	169	38	ed	ed	NN
cord-018834-4ligp4ak	169	39	endosomes	endosome	NNS
cord-018834-4ligp4ak	169	40	are	be	VBP
cord-018834-4ligp4ak	169	41	transported	transport	VBN
cord-018834-4ligp4ak	169	42	back	back	RB
cord-018834-4ligp4ak	169	43	to	to	IN
cord-018834-4ligp4ak	169	44	the	the	DT
cord-018834-4ligp4ak	169	45	cell	cell	NN
cord-018834-4ligp4ak	169	46	surface	surface	NN
cord-018834-4ligp4ak	169	47	where	where	WRB
cord-018834-4ligp4ak	169	48	physiological	physiological	JJ
cord-018834-4ligp4ak	169	49	pH	ph	NN
cord-018834-4ligp4ak	169	50	of	of	IN
cord-018834-4ligp4ak	169	51	the	the	DT
cord-018834-4ligp4ak	169	52	blood	blood	NN
cord-018834-4ligp4ak	169	53	triggers	trigger	NNS
cord-018834-4ligp4ak	169	54	release	release	NN
cord-018834-4ligp4ak	169	55	of	of	IN
cord-018834-4ligp4ak	169	56	the	the	DT
cord-018834-4ligp4ak	169	57	ligands	ligand	NNS
cord-018834-4ligp4ak	169	58	into	into	IN
cord-018834-4ligp4ak	169	59	the	the	DT
cord-018834-4ligp4ak	169	60	blood	blood	NN
cord-018834-4ligp4ak	169	61	circulation	circulation	NN
cord-018834-4ligp4ak	169	62	.	.	.
cord-018834-4ligp4ak	170	1	The	the	DT
cord-018834-4ligp4ak	170	2	intracellular	intracellular	JJ
cord-018834-4ligp4ak	170	3	nonbound	nonbound	NN
cord-018834-4ligp4ak	170	4	fractions	fraction	NNS
cord-018834-4ligp4ak	170	5	are	be	VBP
cord-018834-4ligp4ak	170	6	targeted	target	VBN
cord-018834-4ligp4ak	170	7	for	for	IN
cord-018834-4ligp4ak	170	8	lysosomal	lysosomal	JJ
cord-018834-4ligp4ak	170	9	degradation	degradation	NN
cord-018834-4ligp4ak	170	10	.	.	.
cord-018834-4ligp4ak	171	1	FcRn	FcRn	NNP
cord-018834-4ligp4ak	171	2	is	be	VBZ
cord-018834-4ligp4ak	171	3	also	also	RB
cord-018834-4ligp4ak	171	4	largely	largely	RB
cord-018834-4ligp4ak	171	5	responsible	responsible	JJ
cord-018834-4ligp4ak	171	6	for	for	IN
cord-018834-4ligp4ak	171	7	transporting	transport	VBG
cord-018834-4ligp4ak	171	8	the	the	DT
cord-018834-4ligp4ak	171	9	IgG	igg	NN
cord-018834-4ligp4ak	171	10	across	across	IN
cord-018834-4ligp4ak	171	11	the	the	DT
cord-018834-4ligp4ak	171	12	placenta	placenta	NN
cord-018834-4ligp4ak	171	13	whereby	whereby	WRB
cord-018834-4ligp4ak	171	14	the	the	DT
cord-018834-4ligp4ak	171	15	IgG	igg	NN
cord-018834-4ligp4ak	171	16	concentration	concentration	NN
cord-018834-4ligp4ak	171	17	in	in	IN
cord-018834-4ligp4ak	171	18	newborns	newborn	NNS
cord-018834-4ligp4ak	171	19	at	at	IN
cord-018834-4ligp4ak	171	20	term	term	NN
cord-018834-4ligp4ak	171	21	normally	normally	RB
cord-018834-4ligp4ak	171	22	exceeds	exceed	VBZ
cord-018834-4ligp4ak	171	23	that	that	DT
cord-018834-4ligp4ak	171	24	of	of	IN
cord-018834-4ligp4ak	171	25	the	the	DT
cord-018834-4ligp4ak	171	26	mother	mother	NN
cord-018834-4ligp4ak	171	27	.	.	.
cord-018834-4ligp4ak	172	1	Animals	animal	NNS
cord-018834-4ligp4ak	172	2	defi	defi	IN
cord-018834-4ligp4ak	172	3	cient	cient	NN
cord-018834-4ligp4ak	172	4	in	in	IN
cord-018834-4ligp4ak	172	5	FcRn	FcRn	NNP
cord-018834-4ligp4ak	172	6	catabolize	catabolize	VB
cord-018834-4ligp4ak	172	7	IgG	igg	NN
cord-018834-4ligp4ak	172	8	and	and	CC
cord-018834-4ligp4ak	172	9	albumin	albumin	NN
cord-018834-4ligp4ak	172	10	more	more	RBR
cord-018834-4ligp4ak	172	11	rapidly	rapidly	RB
cord-018834-4ligp4ak	172	12	than	than	IN
cord-018834-4ligp4ak	172	13	normal	normal	JJ
cord-018834-4ligp4ak	172	14	animals	animal	NNS
cord-018834-4ligp4ak	172	15	and	and	CC
cord-018834-4ligp4ak	172	16	manifest	manifest	VB
cord-018834-4ligp4ak	172	17	low	low	JJ
cord-018834-4ligp4ak	172	18	plasma	plasma	NN
cord-018834-4ligp4ak	172	19	concentrations	concentration	NNS
cord-018834-4ligp4ak	172	20	of	of	IN
cord-018834-4ligp4ak	172	21	both	both	DT
cord-018834-4ligp4ak	172	22	molecules	molecule	NNS
cord-018834-4ligp4ak	172	23	.	.	.
cord-018834-4ligp4ak	173	1	Familial	familial	JJ
cord-018834-4ligp4ak	173	2	hypercatabolic	hypercatabolic	NN
cord-018834-4ligp4ak	173	3	hyoproteinemia	hyoproteinemia	NN
cord-018834-4ligp4ak	173	4	,	,	,
cord-018834-4ligp4ak	173	5	where	where	WRB
cord-018834-4ligp4ak	173	6	defi	defi	NNP
cord-018834-4ligp4ak	173	7	ciency	ciency	NNP
cord-018834-4ligp4ak	173	8	of	of	IN
cord-018834-4ligp4ak	173	9	FcRn	FcRn	NNP
cord-018834-4ligp4ak	173	10	is	be	VBZ
cord-018834-4ligp4ak	173	11	due	due	JJ
cord-018834-4ligp4ak	173	12	to	to	IN
cord-018834-4ligp4ak	173	13	mutation	mutation	NN
cord-018834-4ligp4ak	173	14	in	in	IN
cord-018834-4ligp4ak	173	15	β	β	NN
cord-018834-4ligp4ak	173	16	(	(	-LRB-
cord-018834-4ligp4ak	173	17	beta	beta	NN
cord-018834-4ligp4ak	173	18	)	)	-RRB-
cord-018834-4ligp4ak	173	19	2	2	CD
cord-018834-4ligp4ak	173	20	m	m	NN
cord-018834-4ligp4ak	173	21	results	result	NNS
cord-018834-4ligp4ak	173	22	in	in	IN
cord-018834-4ligp4ak	173	23	hypercatabolism	hypercatabolism	NN
cord-018834-4ligp4ak	173	24	and	and	CC
cord-018834-4ligp4ak	173	25	low	low	JJ
cord-018834-4ligp4ak	173	26	plasma	plasma	NN
cord-018834-4ligp4ak	173	27	concentrations	concentration	NNS
cord-018834-4ligp4ak	173	28	of	of	IN
cord-018834-4ligp4ak	173	29	both	both	DT
cord-018834-4ligp4ak	173	30	albumin	albumin	NN
cord-018834-4ligp4ak	174	1	and	and	CC
cord-018834-4ligp4ak	174	2	IgG.	IgG.	NNP
cord-018834-4ligp4ak	174	3	However	however	RB
cord-018834-4ligp4ak	174	4	,	,	,
cord-018834-4ligp4ak	174	5	patients	patient	NNS
cord-018834-4ligp4ak	174	6	with	with	IN
cord-018834-4ligp4ak	174	7	myotonic	myotonic	JJ
cord-018834-4ligp4ak	174	8	dystrophy	dystrophy	NN
cord-018834-4ligp4ak	174	9	(	(	-LRB-
cord-018834-4ligp4ak	174	10	DM	DM	NNP
cord-018834-4ligp4ak	174	11	)	)	-RRB-
cord-018834-4ligp4ak	174	12	exhibit	exhibit	NN
cord-018834-4ligp4ak	174	13	plasma	plasma	NN
cord-018834-4ligp4ak	174	14	defi	defi	NN
cord-018834-4ligp4ak	174	15	ciency	ciency	NN
cord-018834-4ligp4ak	174	16	only	only	RB
cord-018834-4ligp4ak	174	17	in	in	IN
cord-018834-4ligp4ak	174	18	IgG	IgG	NNP
cord-018834-4ligp4ak	175	1	but	but	CC
cord-018834-4ligp4ak	175	2	not	not	RB
cord-018834-4ligp4ak	175	3	albumin	albumin	NN
cord-018834-4ligp4ak	175	4	caused	cause	VBN
cord-018834-4ligp4ak	175	5	by	by	IN
cord-018834-4ligp4ak	175	6	reduced	reduce	VBN
cord-018834-4ligp4ak	175	7	affi	affi	NNP
cord-018834-4ligp4ak	175	8	nity	nity	NN
cord-018834-4ligp4ak	175	9	of	of	IN
cord-018834-4ligp4ak	175	10	FcRn	FcRn	NNP
cord-018834-4ligp4ak	175	11	to	to	IN
cord-018834-4ligp4ak	175	12	IgG	IgG	NNP
cord-018834-4ligp4ak	175	13	[	[	-LRB-
cord-018834-4ligp4ak	175	14	35	35	CD
cord-018834-4ligp4ak	175	15	-37	-37	NNP
cord-018834-4ligp4ak	175	16	]	]	-RRB-
cord-018834-4ligp4ak	175	17	.	.	.
cord-018834-4ligp4ak	176	1	The	the	DT
cord-018834-4ligp4ak	176	2	catabolism	catabolism	NN
cord-018834-4ligp4ak	176	3	of	of	IN
cord-018834-4ligp4ak	176	4	HSA	HSA	NNP
cord-018834-4ligp4ak	176	5	takes	take	VBZ
cord-018834-4ligp4ak	176	6	place	place	NN
cord-018834-4ligp4ak	176	7	in	in	IN
cord-018834-4ligp4ak	176	8	several	several	JJ
cord-018834-4ligp4ak	176	9	organs	organ	NNS
cord-018834-4ligp4ak	176	10	at	at	IN
cord-018834-4ligp4ak	176	11	a	a	DT
cord-018834-4ligp4ak	176	12	rate	rate	NN
cord-018834-4ligp4ak	176	13	of	of	IN
cord-018834-4ligp4ak	176	14	about	about	IN
cord-018834-4ligp4ak	176	15	14	14	CD
cord-018834-4ligp4ak	176	16	g	g	NN
cord-018834-4ligp4ak	176	17	per	per	IN
cord-018834-4ligp4ak	176	18	day	day	NN
cord-018834-4ligp4ak	176	19	in	in	IN
cord-018834-4ligp4ak	176	20	a	a	DT
cord-018834-4ligp4ak	176	21	70	70	CD
cord-018834-4ligp4ak	176	22	kg	kg	NN
cord-018834-4ligp4ak	176	23	healthy	healthy	JJ
cord-018834-4ligp4ak	176	24	adult	adult	NN
cord-018834-4ligp4ak	176	25	,	,	,
cord-018834-4ligp4ak	176	26	or	or	CC
cord-018834-4ligp4ak	176	27	4	4	CD
cord-018834-4ligp4ak	176	28	%	%	NN
cord-018834-4ligp4ak	176	29	of	of	IN
cord-018834-4ligp4ak	176	30	whole	whole	JJ
cord-018834-4ligp4ak	176	31	body	body	NN
cord-018834-4ligp4ak	176	32	protein	protein	NN
cord-018834-4ligp4ak	176	33	turnover	turnover	NN
cord-018834-4ligp4ak	176	34	.	.	.
cord-018834-4ligp4ak	177	1	The	the	DT
cord-018834-4ligp4ak	177	2	rate	rate	NN
cord-018834-4ligp4ak	177	3	of	of	IN
cord-018834-4ligp4ak	177	4	HAS	have	VBZ
cord-018834-4ligp4ak	177	5	catabolism	catabolism	NN
cord-018834-4ligp4ak	177	6	is	be	VBZ
cord-018834-4ligp4ak	177	7	increased	increase	VBN
cord-018834-4ligp4ak	177	8	by	by	IN
cord-018834-4ligp4ak	177	9	protein	protein	NN
cord-018834-4ligp4ak	177	10	and	and	CC
cord-018834-4ligp4ak	177	11	caloric	caloric	JJ
cord-018834-4ligp4ak	177	12	deprivation	deprivation	NN
cord-018834-4ligp4ak	177	13	as	as	IN
cord-018834-4ligp4ak	177	14	HSA	HSA	NNP
cord-018834-4ligp4ak	177	15	is	be	VBZ
cord-018834-4ligp4ak	177	16	used	use	VBN
cord-018834-4ligp4ak	177	17	as	as	IN
cord-018834-4ligp4ak	177	18	a	a	DT
cord-018834-4ligp4ak	177	19	source	source	NN
cord-018834-4ligp4ak	177	20	of	of	IN
cord-018834-4ligp4ak	177	21	energy	energy	NN
cord-018834-4ligp4ak	177	22	.	.	.
cord-018834-4ligp4ak	178	1	The	the	DT
cord-018834-4ligp4ak	178	2	mechanism	mechanism	NN
cord-018834-4ligp4ak	178	3	of	of	IN
cord-018834-4ligp4ak	178	4	HSA	HSA	NNP
cord-018834-4ligp4ak	178	5	breakdown	breakdown	NN
cord-018834-4ligp4ak	178	6	involves	involve	VBZ
cord-018834-4ligp4ak	178	7	protein	protein	NN
cord-018834-4ligp4ak	178	8	uptake	uptake	NN
cord-018834-4ligp4ak	178	9	into	into	IN
cord-018834-4ligp4ak	178	10	endocytotic	endocytotic	JJ
cord-018834-4ligp4ak	178	11	vesicles	vesicle	NNS
cord-018834-4ligp4ak	178	12	,	,	,
cord-018834-4ligp4ak	178	13	which	which	WDT
cord-018834-4ligp4ak	178	14	fuse	fuse	VBP
cord-018834-4ligp4ak	178	15	with	with	IN
cord-018834-4ligp4ak	178	16	lysosomes	lysosome	NNS
cord-018834-4ligp4ak	178	17	of	of	IN
cord-018834-4ligp4ak	178	18	endothelial	endothelial	JJ
cord-018834-4ligp4ak	178	19	cells	cell	NNS
cord-018834-4ligp4ak	178	20	.	.	.
cord-018834-4ligp4ak	179	1	Circulating	circulate	VBG
cord-018834-4ligp4ak	179	2	HSA	HSA	NNP
cord-018834-4ligp4ak	179	3	is	be	VBZ
cord-018834-4ligp4ak	179	4	also	also	RB
cord-018834-4ligp4ak	179	5	lost	lose	VBN
cord-018834-4ligp4ak	179	6	into	into	IN
cord-018834-4ligp4ak	179	7	the	the	DT
cord-018834-4ligp4ak	179	8	intestinal	intestinal	JJ
cord-018834-4ligp4ak	179	9	tract	tract	NN
cord-018834-4ligp4ak	179	10	(	(	-LRB-
cord-018834-4ligp4ak	179	11	about	about	RB
cord-018834-4ligp4ak	179	12	1	1	CD
cord-018834-4ligp4ak	179	13	g	g	NN
cord-018834-4ligp4ak	179	14	each	each	DT
cord-018834-4ligp4ak	179	15	day	day	NN
cord-018834-4ligp4ak	179	16	)	)	-RRB-
cord-018834-4ligp4ak	179	17	,	,	,
cord-018834-4ligp4ak	179	18	where	where	WRB
cord-018834-4ligp4ak	179	19	digestion	digestion	NN
cord-018834-4ligp4ak	179	20	releases	release	VBZ
cord-018834-4ligp4ak	179	21	amino	amino	NN
cord-018834-4ligp4ak	179	22	acids	acid	NNS
cord-018834-4ligp4ak	179	23	and	and	CC
cord-018834-4ligp4ak	179	24	peptides	peptide	NNS
cord-018834-4ligp4ak	179	25	that	that	WDT
cord-018834-4ligp4ak	179	26	are	be	VBP
cord-018834-4ligp4ak	179	27	reabsorbed	reabsorb	VBN
cord-018834-4ligp4ak	179	28	.	.	.
cord-018834-4ligp4ak	180	1	There	there	EX
cord-018834-4ligp4ak	180	2	is	be	VBZ
cord-018834-4ligp4ak	180	3	minimal	minimal	JJ
cord-018834-4ligp4ak	180	4	urinary	urinary	JJ
cord-018834-4ligp4ak	180	5	loss	loss	NN
cord-018834-4ligp4ak	180	6	of	of	IN
cord-018834-4ligp4ak	180	7	HSA	HSA	NNP
cord-018834-4ligp4ak	180	8	in	in	IN
cord-018834-4ligp4ak	180	9	healthy	healthy	JJ
cord-018834-4ligp4ak	180	10	subjects	subject	NNS
cord-018834-4ligp4ak	180	11	.	.	.
cord-018834-4ligp4ak	181	1	It	-PRON-	PRP
cord-018834-4ligp4ak	181	2	is	be	VBZ
cord-018834-4ligp4ak	181	3	worth	worth	JJ
cord-018834-4ligp4ak	181	4	mentioning	mention	VBG
cord-018834-4ligp4ak	181	5	that	that	DT
cord-018834-4ligp4ak	181	6	of	of	IN
cord-018834-4ligp4ak	181	7	the	the	DT
cord-018834-4ligp4ak	181	8	70	70	CD
cord-018834-4ligp4ak	181	9	kg	kg	NNS
cord-018834-4ligp4ak	181	10	of	of	IN
cord-018834-4ligp4ak	181	11	HSA	HSA	NNP
cord-018834-4ligp4ak	181	12	that	that	WDT
cord-018834-4ligp4ak	181	13	passes	pass	VBZ
cord-018834-4ligp4ak	181	14	through	through	IN
cord-018834-4ligp4ak	181	15	the	the	DT
cord-018834-4ligp4ak	181	16	kidneys	kidney	NNS
cord-018834-4ligp4ak	181	17	each	each	DT
cord-018834-4ligp4ak	181	18	day	day	NN
cord-018834-4ligp4ak	181	19	,	,	,
cord-018834-4ligp4ak	181	20	only	only	RB
cord-018834-4ligp4ak	181	21	a	a	DT
cord-018834-4ligp4ak	181	22	few	few	JJ
cord-018834-4ligp4ak	181	23	milligrams	milligram	NNS
cord-018834-4ligp4ak	181	24	are	be	VBP
cord-018834-4ligp4ak	181	25	secreted	secrete	VBN
cord-018834-4ligp4ak	181	26	from	from	IN
cord-018834-4ligp4ak	181	27	kidney	kidney	NN
cord-018834-4ligp4ak	181	28	tubules	tubule	NNS
cord-018834-4ligp4ak	181	29	[	[	-LRB-
cord-018834-4ligp4ak	181	30	13	13	CD
cord-018834-4ligp4ak	181	31	]	]	-RRB-
cord-018834-4ligp4ak	181	32	.	.	.
cord-018834-4ligp4ak	182	1	The	the	DT
cord-018834-4ligp4ak	182	2	use	use	NN
cord-018834-4ligp4ak	182	3	of	of	IN
cord-018834-4ligp4ak	182	4	human	human	JJ
cord-018834-4ligp4ak	182	5	albumin	albumin	NN
cord-018834-4ligp4ak	182	6	in	in	IN
cord-018834-4ligp4ak	182	7	critically	critically	RB
cord-018834-4ligp4ak	182	8	ill	ill	JJ
cord-018834-4ligp4ak	182	9	and	and	CC
cord-018834-4ligp4ak	182	10	septic	septic	JJ
cord-018834-4ligp4ak	182	11	patients	patient	NNS
cord-018834-4ligp4ak	182	12	has	have	VBZ
cord-018834-4ligp4ak	182	13	been	be	VBN
cord-018834-4ligp4ak	182	14	through	through	IN
cord-018834-4ligp4ak	182	15	much	much	JJ
cord-018834-4ligp4ak	182	16	controversy	controversy	NN
cord-018834-4ligp4ak	182	17	in	in	IN
cord-018834-4ligp4ak	182	18	the	the	DT
cord-018834-4ligp4ak	182	19	last	last	JJ
cord-018834-4ligp4ak	182	20	two	two	CD
cord-018834-4ligp4ak	182	21	decades	decade	NNS
cord-018834-4ligp4ak	182	22	.	.	.
cord-018834-4ligp4ak	183	1	In	in	IN
cord-018834-4ligp4ak	183	2	1998	1998	CD
cord-018834-4ligp4ak	183	3	,	,	,
cord-018834-4ligp4ak	183	4	a	a	DT
cord-018834-4ligp4ak	183	5	Cochrane	Cochrane	NNP
cord-018834-4ligp4ak	183	6	meta	meta	NNP
cord-018834-4ligp4ak	183	7	-	-	HYPH
cord-018834-4ligp4ak	183	8	analysis	analysis	NN
cord-018834-4ligp4ak	183	9	for	for	IN
cord-018834-4ligp4ak	183	10	albumin	albumin	NN
cord-018834-4ligp4ak	183	11	administration	administration	NN
cord-018834-4ligp4ak	183	12	in	in	IN
cord-018834-4ligp4ak	183	13	critically	critically	RB
cord-018834-4ligp4ak	183	14	ill	ill	JJ
cord-018834-4ligp4ak	183	15	patients	patient	NNS
cord-018834-4ligp4ak	183	16	was	be	VBD
cord-018834-4ligp4ak	183	17	published	publish	VBN
cord-018834-4ligp4ak	183	18	in	in	IN
cord-018834-4ligp4ak	183	19	the	the	DT
cord-018834-4ligp4ak	183	20	British	British	NNP
cord-018834-4ligp4ak	183	21	Medical	Medical	NNP
cord-018834-4ligp4ak	183	22	Journal	Journal	NNP
cord-018834-4ligp4ak	183	23	[	[	-LRB-
cord-018834-4ligp4ak	183	24	38	38	CD
cord-018834-4ligp4ak	183	25	]	]	-RRB-
cord-018834-4ligp4ak	183	26	.	.	.
cord-018834-4ligp4ak	184	1	The	the	DT
cord-018834-4ligp4ak	184	2	average	average	JJ
cord-018834-4ligp4ak	184	3	sample	sample	NN
cord-018834-4ligp4ak	184	4	size	size	NN
cord-018834-4ligp4ak	184	5	of	of	IN
cord-018834-4ligp4ak	184	6	the	the	DT
cord-018834-4ligp4ak	184	7	selected	select	VBN
cord-018834-4ligp4ak	184	8	32	32	CD
cord-018834-4ligp4ak	184	9	studies	study	NNS
cord-018834-4ligp4ak	184	10	in	in	IN
cord-018834-4ligp4ak	184	11	this	this	DT
cord-018834-4ligp4ak	184	12	meta	meta	NNP
cord-018834-4ligp4ak	184	13	-	-	HYPH
cord-018834-4ligp4ak	184	14	analysis	analysis	NN
cord-018834-4ligp4ak	184	15	was	be	VBD
cord-018834-4ligp4ak	184	16	just	just	RB
cord-018834-4ligp4ak	184	17	46	46	CD
cord-018834-4ligp4ak	184	18	patients	patient	NNS
cord-018834-4ligp4ak	184	19	.	.	.
cord-018834-4ligp4ak	185	1	The	the	DT
cord-018834-4ligp4ak	185	2	results	result	NNS
cord-018834-4ligp4ak	185	3	of	of	IN
cord-018834-4ligp4ak	185	4	this	this	DT
cord-018834-4ligp4ak	185	5	meta	meta	NNP
cord-018834-4ligp4ak	185	6	-	-	HYPH
cord-018834-4ligp4ak	185	7	analysis	analysis	NN
cord-018834-4ligp4ak	185	8	showed	show	VBD
cord-018834-4ligp4ak	185	9	increased	increased	JJ
cord-018834-4ligp4ak	185	10	mortality	mortality	NN
cord-018834-4ligp4ak	185	11	of	of	IN
cord-018834-4ligp4ak	185	12	almost	almost	RB
cord-018834-4ligp4ak	185	13	70	70	CD
cord-018834-4ligp4ak	185	14	%	%	NN
cord-018834-4ligp4ak	185	15	in	in	IN
cord-018834-4ligp4ak	185	16	patients	patient	NNS
cord-018834-4ligp4ak	185	17	given	give	VBN
cord-018834-4ligp4ak	185	18	albumin	albumin	NN
cord-018834-4ligp4ak	185	19	.	.	.
cord-018834-4ligp4ak	186	1	The	the	DT
cord-018834-4ligp4ak	186	2	results	result	NNS
cord-018834-4ligp4ak	186	3	of	of	IN
cord-018834-4ligp4ak	186	4	this	this	DT
cord-018834-4ligp4ak	186	5	Cochrane	Cochrane	NNP
cord-018834-4ligp4ak	186	6	report	report	NN
cord-018834-4ligp4ak	186	7	changed	change	VBD
cord-018834-4ligp4ak	186	8	the	the	DT
cord-018834-4ligp4ak	186	9	practice	practice	NN
cord-018834-4ligp4ak	186	10	rapidly	rapidly	RB
cord-018834-4ligp4ak	186	11	around	around	IN
cord-018834-4ligp4ak	186	12	the	the	DT
cord-018834-4ligp4ak	186	13	world	world	NN
cord-018834-4ligp4ak	186	14	with	with	IN
cord-018834-4ligp4ak	186	15	dramatic	dramatic	JJ
cord-018834-4ligp4ak	186	16	reduction	reduction	NN
cord-018834-4ligp4ak	186	17	in	in	IN
cord-018834-4ligp4ak	186	18	albumin	albumin	NN
cord-018834-4ligp4ak	186	19	use	use	NN
cord-018834-4ligp4ak	186	20	especially	especially	RB
cord-018834-4ligp4ak	186	21	in	in	IN
cord-018834-4ligp4ak	186	22	Europe	Europe	NNP
cord-018834-4ligp4ak	186	23	.	.	.
cord-018834-4ligp4ak	187	1	The	the	DT
cord-018834-4ligp4ak	187	2	validity	validity	NN
cord-018834-4ligp4ak	187	3	of	of	IN
cord-018834-4ligp4ak	187	4	this	this	DT
cord-018834-4ligp4ak	187	5	meta	meta	NNP
cord-018834-4ligp4ak	187	6	-	-	HYPH
cord-018834-4ligp4ak	187	7	analysis	analysis	NN
cord-018834-4ligp4ak	187	8	has	have	VBZ
cord-018834-4ligp4ak	187	9	been	be	VBN
cord-018834-4ligp4ak	187	10	disputed	dispute	VBN
cord-018834-4ligp4ak	187	11	for	for	IN
cord-018834-4ligp4ak	187	12	several	several	JJ
cord-018834-4ligp4ak	187	13	methodological	methodological	JJ
cord-018834-4ligp4ak	187	14	reasons	reason	NNS
cord-018834-4ligp4ak	187	15	,	,	,
cord-018834-4ligp4ak	187	16	such	such	JJ
cord-018834-4ligp4ak	187	17	as	as	IN
cord-018834-4ligp4ak	187	18	omission	omission	NN
cord-018834-4ligp4ak	187	19	of	of	IN
cord-018834-4ligp4ak	187	20	relevant	relevant	JJ
cord-018834-4ligp4ak	187	21	trials	trial	NNS
cord-018834-4ligp4ak	187	22	,	,	,
cord-018834-4ligp4ak	187	23	small	small	JJ
cord-018834-4ligp4ak	187	24	trials	trial	NNS
cord-018834-4ligp4ak	187	25	bias	bias	NN
cord-018834-4ligp4ak	187	26	,	,	,
cord-018834-4ligp4ak	187	27	and	and	CC
cord-018834-4ligp4ak	187	28	combination	combination	NN
cord-018834-4ligp4ak	187	29	of	of	IN
cord-018834-4ligp4ak	187	30	heterogeneous	heterogeneous	JJ
cord-018834-4ligp4ak	187	31	trials	trial	NNS
cord-018834-4ligp4ak	187	32	,	,	,
cord-018834-4ligp4ak	187	33	which	which	WDT
cord-018834-4ligp4ak	187	34	included	include	VBD
cord-018834-4ligp4ak	187	35	adults	adult	NNS
cord-018834-4ligp4ak	187	36	and	and	CC
cord-018834-4ligp4ak	187	37	high	high	JJ
cord-018834-4ligp4ak	187	38	-	-	HYPH
cord-018834-4ligp4ak	187	39	risk	risk	NN
cord-018834-4ligp4ak	187	40	neonates	neonate	NNS
cord-018834-4ligp4ak	187	41	,	,	,
cord-018834-4ligp4ak	187	42	inadequate	inadequate	JJ
cord-018834-4ligp4ak	187	43	assessment	assessment	NN
cord-018834-4ligp4ak	187	44	of	of	IN
cord-018834-4ligp4ak	187	45	the	the	DT
cord-018834-4ligp4ak	187	46	effect	effect	NN
cord-018834-4ligp4ak	187	47	of	of	IN
cord-018834-4ligp4ak	187	48	methodological	methodological	JJ
cord-018834-4ligp4ak	187	49	quality	quality	NN
cord-018834-4ligp4ak	187	50	on	on	IN
cord-018834-4ligp4ak	187	51	outcome	outcome	NN
cord-018834-4ligp4ak	187	52	,	,	,
cord-018834-4ligp4ak	187	53	and	and	CC
cord-018834-4ligp4ak	187	54	the	the	DT
cord-018834-4ligp4ak	187	55	absence	absence	NN
cord-018834-4ligp4ak	187	56	of	of	IN
cord-018834-4ligp4ak	187	57	a	a	DT
cord-018834-4ligp4ak	187	58	plausible	plausible	JJ
cord-018834-4ligp4ak	187	59	mechanism	mechanism	NN
cord-018834-4ligp4ak	187	60	to	to	TO
cord-018834-4ligp4ak	187	61	explain	explain	VB
cord-018834-4ligp4ak	187	62	albumin	albumin	NN
cord-018834-4ligp4ak	187	63	-	-	HYPH
cord-018834-4ligp4ak	187	64	associated	associate	VBN
cord-018834-4ligp4ak	187	65	excess	excess	JJ
cord-018834-4ligp4ak	187	66	mortality	mortality	NN
cord-018834-4ligp4ak	187	67	[	[	-LRB-
cord-018834-4ligp4ak	187	68	39	39	CD
cord-018834-4ligp4ak	187	69	,	,	,
cord-018834-4ligp4ak	187	70	40	40	CD
cord-018834-4ligp4ak	187	71	]	]	-RRB-
cord-018834-4ligp4ak	187	72	.	.	.
cord-018834-4ligp4ak	188	1	Moreover	moreover	RB
cord-018834-4ligp4ak	188	2	,	,	,
cord-018834-4ligp4ak	188	3	the	the	DT
cord-018834-4ligp4ak	188	4	meta	meta	NNP
cord-018834-4ligp4ak	188	5	-	-	HYPH
cord-018834-4ligp4ak	188	6	analysis	analysis	NN
cord-018834-4ligp4ak	188	7	did	do	VBD
cord-018834-4ligp4ak	188	8	not	not	RB
cord-018834-4ligp4ak	188	9	include	include	VB
cord-018834-4ligp4ak	188	10	burns	burn	NNS
cord-018834-4ligp4ak	188	11	trials	trial	NNS
cord-018834-4ligp4ak	188	12	in	in	IN
cord-018834-4ligp4ak	188	13	which	which	WDT
cord-018834-4ligp4ak	188	14	the	the	DT
cord-018834-4ligp4ak	188	15	mortality	mortality	NN
cord-018834-4ligp4ak	188	16	rate	rate	NN
cord-018834-4ligp4ak	188	17	was	be	VBD
cord-018834-4ligp4ak	188	18	lower	low	JJR
cord-018834-4ligp4ak	188	19	in	in	IN
cord-018834-4ligp4ak	188	20	albumin	albumin	NN
cord-018834-4ligp4ak	188	21	[	[	-LRB-
cord-018834-4ligp4ak	188	22	41	41	CD
cord-018834-4ligp4ak	188	23	]	]	-RRB-
cord-018834-4ligp4ak	188	24	.	.	.
cord-018834-4ligp4ak	189	1	Finally	finally	RB
cord-018834-4ligp4ak	189	2	,	,	,
cord-018834-4ligp4ak	189	3	the	the	DT
cord-018834-4ligp4ak	189	4	crossover	crossover	NN
cord-018834-4ligp4ak	189	5	pattern	pattern	NN
cord-018834-4ligp4ak	189	6	in	in	IN
cord-018834-4ligp4ak	189	7	which	which	WDT
cord-018834-4ligp4ak	189	8	the	the	DT
cord-018834-4ligp4ak	189	9	most	most	RBS
cord-018834-4ligp4ak	189	10	seriously	seriously	RB
cord-018834-4ligp4ak	189	11	ill	ill	JJ
cord-018834-4ligp4ak	189	12	patients	patient	NNS
cord-018834-4ligp4ak	189	13	in	in	IN
cord-018834-4ligp4ak	189	14	the	the	DT
cord-018834-4ligp4ak	189	15	control	control	NN
cord-018834-4ligp4ak	189	16	group	group	NN
cord-018834-4ligp4ak	189	17	were	be	VBD
cord-018834-4ligp4ak	189	18	switched	switch	VBN
cord-018834-4ligp4ak	189	19	to	to	IN
cord-018834-4ligp4ak	189	20	albumin	albumin	NN
cord-018834-4ligp4ak	189	21	as	as	IN
cord-018834-4ligp4ak	189	22	a	a	DT
cord-018834-4ligp4ak	189	23	rescue	rescue	NN
cord-018834-4ligp4ak	189	24	measure	measure	NN
cord-018834-4ligp4ak	189	25	,	,	,
cord-018834-4ligp4ak	189	26	therefore	therefore	RB
cord-018834-4ligp4ak	189	27	,	,	,
cord-018834-4ligp4ak	189	28	would	would	MD
cord-018834-4ligp4ak	189	29	bias	bias	VB
cord-018834-4ligp4ak	189	30	the	the	DT
cord-018834-4ligp4ak	189	31	pooled	pool	VBN
cord-018834-4ligp4ak	189	32	estimates	estimate	NNS
cord-018834-4ligp4ak	189	33	of	of	IN
cord-018834-4ligp4ak	189	34	relative	relative	JJ
cord-018834-4ligp4ak	189	35	risk	risk	NN
cord-018834-4ligp4ak	189	36	in	in	IN
cord-018834-4ligp4ak	189	37	favor	favor	NN
cord-018834-4ligp4ak	189	38	of	of	IN
cord-018834-4ligp4ak	189	39	the	the	DT
cord-018834-4ligp4ak	189	40	control	control	NN
cord-018834-4ligp4ak	189	41	group	group	NN
cord-018834-4ligp4ak	189	42	[	[	-LRB-
cord-018834-4ligp4ak	189	43	40	40	CD
cord-018834-4ligp4ak	189	44	]	]	-RRB-
cord-018834-4ligp4ak	189	45	.	.	.
cord-018834-4ligp4ak	190	1	Only	only	RB
cord-018834-4ligp4ak	190	2	a	a	DT
cord-018834-4ligp4ak	190	3	few	few	JJ
cord-018834-4ligp4ak	190	4	years	year	NNS
cord-018834-4ligp4ak	190	5	later	later	RB
cord-018834-4ligp4ak	190	6	,	,	,
cord-018834-4ligp4ak	190	7	this	this	DT
cord-018834-4ligp4ak	190	8	meta	meta	NNP
cord-018834-4ligp4ak	190	9	-	-	HYPH
cord-018834-4ligp4ak	190	10	analysis	analysis	NN
cord-018834-4ligp4ak	190	11	was	be	VBD
cord-018834-4ligp4ak	190	12	followed	follow	VBN
cord-018834-4ligp4ak	190	13	by	by	IN
cord-018834-4ligp4ak	190	14	an	an	DT
cord-018834-4ligp4ak	190	15	updated	update	VBN
cord-018834-4ligp4ak	190	16	meta	meta	NN
cord-018834-4ligp4ak	190	17	-	-	HYPH
cord-018834-4ligp4ak	190	18	analysis	analysis	NNP
cord-018834-4ligp4ak	190	19	,	,	,
cord-018834-4ligp4ak	190	20	in	in	IN
cord-018834-4ligp4ak	190	21	which	which	WDT
cord-018834-4ligp4ak	190	22	55	55	CD
cord-018834-4ligp4ak	190	23	trials	trial	NNS
cord-018834-4ligp4ak	190	24	involving	involve	VBG
cord-018834-4ligp4ak	190	25	3,504	3,504	CD
cord-018834-4ligp4ak	190	26	randomly	randomly	RB
cord-018834-4ligp4ak	190	27	assigned	assign	VBN
cord-018834-4ligp4ak	190	28	patients	patient	NNS
cord-018834-4ligp4ak	190	29	had	have	VBD
cord-018834-4ligp4ak	190	30	been	be	VBN
cord-018834-4ligp4ak	190	31	included	include	VBN
cord-018834-4ligp4ak	190	32	and	and	CC
cord-018834-4ligp4ak	190	33	525	525	CD
cord-018834-4ligp4ak	190	34	deaths	death	NNS
cord-018834-4ligp4ak	190	35	occurred	occur	VBD
cord-018834-4ligp4ak	190	36	[	[	-LRB-
cord-018834-4ligp4ak	190	37	40	40	CD
cord-018834-4ligp4ak	190	38	]	]	-RRB-
cord-018834-4ligp4ak	190	39	.	.	.
cord-018834-4ligp4ak	191	1	Pooled	pool	VBN
cord-018834-4ligp4ak	191	2	relative	relative	JJ
cord-018834-4ligp4ak	191	3	risk	risk	NN
cord-018834-4ligp4ak	191	4	estimates	estimate	NNS
cord-018834-4ligp4ak	191	5	among	among	IN
cord-018834-4ligp4ak	191	6	trials	trial	NNS
cord-018834-4ligp4ak	191	7	with	with	IN
cord-018834-4ligp4ak	191	8	blinding	blind	VBG
cord-018834-4ligp4ak	191	9	and	and	CC
cord-018834-4ligp4ak	191	10	those	those	DT
cord-018834-4ligp4ak	191	11	with	with	IN
cord-018834-4ligp4ak	191	12	100	100	CD
cord-018834-4ligp4ak	191	13	or	or	CC
cord-018834-4ligp4ak	191	14	more	more	JJR
cord-018834-4ligp4ak	191	15	patients	patient	NNS
cord-018834-4ligp4ak	191	16	were	be	VBD
cord-018834-4ligp4ak	191	17	0.73	0.73	CD
cord-018834-4ligp4ak	191	18	(	(	-LRB-
cord-018834-4ligp4ak	191	19	CI	CI	NNP
cord-018834-4ligp4ak	191	20	,	,	,
cord-018834-4ligp4ak	191	21	0.48	0.48	CD
cord-018834-4ligp4ak	191	22	-	-	HYPH
cord-018834-4ligp4ak	191	23	1.12	1.12	CD
cord-018834-4ligp4ak	191	24	)	)	-RRB-
cord-018834-4ligp4ak	191	25	and	and	CC
cord-018834-4ligp4ak	191	26	0.94	0.94	CD
cord-018834-4ligp4ak	192	1	(	(	-LRB-
cord-018834-4ligp4ak	192	2	CI	CI	NNP
cord-018834-4ligp4ak	192	3	0.77	0.77	CD
cord-018834-4ligp4ak	192	4	-	-	SYM
cord-018834-4ligp4ak	192	5	1.14	1.14	CD
cord-018834-4ligp4ak	192	6	)	)	-RRB-
cord-018834-4ligp4ak	192	7	,	,	,
cord-018834-4ligp4ak	192	8	respectively	respectively	RB
cord-018834-4ligp4ak	192	9	.	.	.
cord-018834-4ligp4ak	193	1	The	the	DT
cord-018834-4ligp4ak	193	2	relative	relative	JJ
cord-018834-4ligp4ak	193	3	risk	risk	NN
cord-018834-4ligp4ak	193	4	was	be	VBD
cord-018834-4ligp4ak	193	5	also	also	RB
cord-018834-4ligp4ak	193	6	consistently	consistently	RB
cord-018834-4ligp4ak	193	7	less	less	JJR
cord-018834-4ligp4ak	193	8	than	than	IN
cord-018834-4ligp4ak	193	9	1.0	1.0	CD
cord-018834-4ligp4ak	193	10	for	for	IN
cord-018834-4ligp4ak	193	11	trials	trial	NNS
cord-018834-4ligp4ak	193	12	that	that	WDT
cord-018834-4ligp4ak	193	13	had	have	VBD
cord-018834-4ligp4ak	193	14	two	two	CD
cord-018834-4ligp4ak	193	15	or	or	CC
cord-018834-4ligp4ak	193	16	more	more	JJR
cord-018834-4ligp4ak	193	17	of	of	IN
cord-018834-4ligp4ak	193	18	the	the	DT
cord-018834-4ligp4ak	193	19	four	four	CD
cord-018834-4ligp4ak	193	20	attributes	attribute	NNS
cord-018834-4ligp4ak	193	21	indicating	indicate	VBG
cord-018834-4ligp4ak	193	22	higher	high	JJR
cord-018834-4ligp4ak	193	23	methodological	methodological	JJ
cord-018834-4ligp4ak	193	24	quality	quality	NN
cord-018834-4ligp4ak	193	25	such	such	JJ
cord-018834-4ligp4ak	193	26	as	as	IN
cord-018834-4ligp4ak	193	27	blinding	blind	VBG
cord-018834-4ligp4ak	193	28	,	,	,
cord-018834-4ligp4ak	193	29	mortality	mortality	NN
cord-018834-4ligp4ak	193	30	as	as	IN
cord-018834-4ligp4ak	193	31	an	an	DT
cord-018834-4ligp4ak	193	32	endpoint	endpoint	NN
cord-018834-4ligp4ak	193	33	,	,	,
cord-018834-4ligp4ak	193	34	no	no	DT
cord-018834-4ligp4ak	193	35	crossover	crossover	NN
cord-018834-4ligp4ak	193	36	,	,	,
cord-018834-4ligp4ak	193	37	and	and	CC
cord-018834-4ligp4ak	193	38	100	100	CD
cord-018834-4ligp4ak	193	39	or	or	CC
cord-018834-4ligp4ak	193	40	more	more	JJR
cord-018834-4ligp4ak	193	41	patients	patient	NNS
cord-018834-4ligp4ak	193	42	.	.	.
cord-018834-4ligp4ak	194	1	These	these	DT
cord-018834-4ligp4ak	194	2	observations	observation	NNS
cord-018834-4ligp4ak	194	3	suggest	suggest	VBP
cord-018834-4ligp4ak	194	4	that	that	IN
cord-018834-4ligp4ak	194	5	albumin	albumin	NN
cord-018834-4ligp4ak	194	6	therapy	therapy	NN
cord-018834-4ligp4ak	194	7	reduces	reduce	VBZ
cord-018834-4ligp4ak	194	8	mortality	mortality	NN
cord-018834-4ligp4ak	194	9	.	.	.
cord-018834-4ligp4ak	195	1	Overall	overall	RB
cord-018834-4ligp4ak	195	2	,	,	,
cord-018834-4ligp4ak	195	3	the	the	DT
cord-018834-4ligp4ak	195	4	results	result	NNS
cord-018834-4ligp4ak	195	5	of	of	IN
cord-018834-4ligp4ak	195	6	this	this	DT
cord-018834-4ligp4ak	195	7	meta	meta	NNP
cord-018834-4ligp4ak	195	8	-	-	HYPH
cord-018834-4ligp4ak	195	9	analysis	analysis	NN
cord-018834-4ligp4ak	195	10	supported	support	VBD
cord-018834-4ligp4ak	195	11	the	the	DT
cord-018834-4ligp4ak	195	12	safety	safety	NN
cord-018834-4ligp4ak	195	13	of	of	IN
cord-018834-4ligp4ak	195	14	albumin	albumin	NN
cord-018834-4ligp4ak	195	15	use	use	NN
cord-018834-4ligp4ak	195	16	in	in	IN
cord-018834-4ligp4ak	195	17	critically	critically	RB
cord-018834-4ligp4ak	195	18	ill	ill	JJ
cord-018834-4ligp4ak	195	19	patients	patient	NNS
cord-018834-4ligp4ak	195	20	.	.	.
cord-018834-4ligp4ak	196	1	In	in	IN
cord-018834-4ligp4ak	196	2	2004	2004	CD
cord-018834-4ligp4ak	196	3	,	,	,
cord-018834-4ligp4ak	196	4	the	the	DT
cord-018834-4ligp4ak	196	5	results	result	NNS
cord-018834-4ligp4ak	196	6	of	of	IN
cord-018834-4ligp4ak	196	7	the	the	DT
cord-018834-4ligp4ak	196	8	Saline	Saline	NNP
cord-018834-4ligp4ak	196	9	versus	versus	IN
cord-018834-4ligp4ak	196	10	Albumin	Albumin	NNP
cord-018834-4ligp4ak	196	11	Fluid	Fluid	NNP
cord-018834-4ligp4ak	196	12	Evaluation	Evaluation	NNP
cord-018834-4ligp4ak	196	13	(	(	-LRB-
cord-018834-4ligp4ak	196	14	SAFE	SAFE	NNP
cord-018834-4ligp4ak	196	15	)	)	-RRB-
cord-018834-4ligp4ak	196	16	randomized	randomized	JJ
cord-018834-4ligp4ak	196	17	control	control	NN
cord-018834-4ligp4ak	196	18	trial	trial	NN
cord-018834-4ligp4ak	196	19	(	(	-LRB-
cord-018834-4ligp4ak	196	20	RCT	RCT	NNP
cord-018834-4ligp4ak	196	21	)	)	-RRB-
cord-018834-4ligp4ak	196	22	in	in	IN
cord-018834-4ligp4ak	196	23	7,000	7,000	CD
cord-018834-4ligp4ak	196	24	critically	critically	RB
cord-018834-4ligp4ak	196	25	ill	ill	JJ
cord-018834-4ligp4ak	196	26	patients	patient	NNS
cord-018834-4ligp4ak	196	27	were	be	VBD
cord-018834-4ligp4ak	196	28	published	publish	VBN
cord-018834-4ligp4ak	196	29	,	,	,
cord-018834-4ligp4ak	196	30	showing	show	VBG
cord-018834-4ligp4ak	196	31	that	that	IN
cord-018834-4ligp4ak	196	32	a	a	DT
cord-018834-4ligp4ak	196	33	4	4	CD
cord-018834-4ligp4ak	196	34	%	%	NN
cord-018834-4ligp4ak	196	35	albumin	albumin	NN
cord-018834-4ligp4ak	196	36	solution	solution	NN
cord-018834-4ligp4ak	196	37	was	be	VBD
cord-018834-4ligp4ak	196	38	as	as	RB
cord-018834-4ligp4ak	196	39	safe	safe	JJ
cord-018834-4ligp4ak	196	40	as	as	IN
cord-018834-4ligp4ak	196	41	normal	normal	JJ
cord-018834-4ligp4ak	196	42	saline	saline	NN
cord-018834-4ligp4ak	196	43	as	as	IN
cord-018834-4ligp4ak	196	44	resuscitative	resuscitative	JJ
cord-018834-4ligp4ak	196	45	fl	fl	NNP
cord-018834-4ligp4ak	196	46	uid	uid	NN
cord-018834-4ligp4ak	196	47	in	in	IN
cord-018834-4ligp4ak	196	48	critically	critically	RB
cord-018834-4ligp4ak	196	49	ill	ill	JJ
cord-018834-4ligp4ak	196	50	patients	patient	NNS
cord-018834-4ligp4ak	196	51	[	[	-LRB-
cord-018834-4ligp4ak	196	52	42	42	CD
cord-018834-4ligp4ak	196	53	]	]	-RRB-
cord-018834-4ligp4ak	196	54	.	.	.
cord-018834-4ligp4ak	197	1	Furthermore	furthermore	RB
cord-018834-4ligp4ak	197	2	,	,	,
cord-018834-4ligp4ak	197	3	the	the	DT
cord-018834-4ligp4ak	197	4	subgroup	subgroup	NN
cord-018834-4ligp4ak	197	5	analysis	analysis	NN
cord-018834-4ligp4ak	197	6	of	of	IN
cord-018834-4ligp4ak	197	7	the	the	DT
cord-018834-4ligp4ak	197	8	SAFE	safe	JJ
cord-018834-4ligp4ak	197	9	study	study	NN
cord-018834-4ligp4ak	197	10	showed	show	VBD
cord-018834-4ligp4ak	197	11	benefi	benefi	NNP
cord-018834-4ligp4ak	197	12	t	t	NN
cord-018834-4ligp4ak	197	13	of	of	IN
cord-018834-4ligp4ak	197	14	using	use	VBG
cord-018834-4ligp4ak	197	15	albumin	albumin	NN
cord-018834-4ligp4ak	197	16	in	in	IN
cord-018834-4ligp4ak	197	17	patients	patient	NNS
cord-018834-4ligp4ak	197	18	with	with	IN
cord-018834-4ligp4ak	197	19	severe	severe	JJ
cord-018834-4ligp4ak	197	20	sepsis	sepsis	NN
cord-018834-4ligp4ak	197	21	,	,	,
cord-018834-4ligp4ak	197	22	with	with	IN
cord-018834-4ligp4ak	197	23	an	an	DT
cord-018834-4ligp4ak	197	24	adjusted	adjust	VBN
cord-018834-4ligp4ak	197	25	odds	odd	NNS
cord-018834-4ligp4ak	197	26	ratio	ratio	NN
cord-018834-4ligp4ak	197	27	(	(	-LRB-
cord-018834-4ligp4ak	197	28	OR	or	CC
cord-018834-4ligp4ak	197	29	)	)	-RRB-
cord-018834-4ligp4ak	197	30	for	for	IN
cord-018834-4ligp4ak	197	31	death	death	NN
cord-018834-4ligp4ak	197	32	of	of	IN
cord-018834-4ligp4ak	197	33	0.71	0.71	CD
cord-018834-4ligp4ak	197	34	(	(	-LRB-
cord-018834-4ligp4ak	197	35	95	95	CD
cord-018834-4ligp4ak	197	36	%	%	NN
cord-018834-4ligp4ak	197	37	CI	CI	NNP
cord-018834-4ligp4ak	197	38	,	,	,
cord-018834-4ligp4ak	197	39	0.52	0.52	CD
cord-018834-4ligp4ak	197	40	-	-	SYM
cord-018834-4ligp4ak	197	41	0.97	0.97	CD
cord-018834-4ligp4ak	197	42	;	;	:
cord-018834-4ligp4ak	197	43	P	p	NN
cord-018834-4ligp4ak	197	44	=	=	SYM
cord-018834-4ligp4ak	197	45	0.03	0.03	CD
cord-018834-4ligp4ak	197	46	)	)	-RRB-
cord-018834-4ligp4ak	197	47	for	for	IN
cord-018834-4ligp4ak	197	48	albumin	albumin	NN
cord-018834-4ligp4ak	197	49	compared	compare	VBN
cord-018834-4ligp4ak	197	50	with	with	IN
cord-018834-4ligp4ak	197	51	saline	saline	NN
cord-018834-4ligp4ak	197	52	.	.	.
cord-018834-4ligp4ak	198	1	Therefore	therefore	RB
cord-018834-4ligp4ak	198	2	,	,	,
cord-018834-4ligp4ak	198	3	the	the	DT
cord-018834-4ligp4ak	198	4	authors	author	NNS
cord-018834-4ligp4ak	198	5	concluded	conclude	VBD
cord-018834-4ligp4ak	198	6	that	that	IN
cord-018834-4ligp4ak	198	7	administration	administration	NN
cord-018834-4ligp4ak	198	8	of	of	IN
cord-018834-4ligp4ak	198	9	albumin	albumin	NN
cord-018834-4ligp4ak	198	10	compared	compare	VBN
cord-018834-4ligp4ak	198	11	to	to	IN
cord-018834-4ligp4ak	198	12	saline	saline	NN
cord-018834-4ligp4ak	198	13	did	do	VBD
cord-018834-4ligp4ak	198	14	not	not	RB
cord-018834-4ligp4ak	198	15	impair	impair	VB
cord-018834-4ligp4ak	198	16	renal	renal	JJ
cord-018834-4ligp4ak	198	17	function	function	NN
cord-018834-4ligp4ak	198	18	or	or	CC
cord-018834-4ligp4ak	198	19	organ	organ	NN
cord-018834-4ligp4ak	198	20	function	function	NN
cord-018834-4ligp4ak	198	21	and	and	CC
cord-018834-4ligp4ak	198	22	may	may	MD
cord-018834-4ligp4ak	198	23	have	have	VB
cord-018834-4ligp4ak	198	24	decreased	decrease	VBN
cord-018834-4ligp4ak	198	25	the	the	DT
cord-018834-4ligp4ak	198	26	risk	risk	NN
cord-018834-4ligp4ak	198	27	of	of	IN
cord-018834-4ligp4ak	198	28	death	death	NN
cord-018834-4ligp4ak	198	29	in	in	IN
cord-018834-4ligp4ak	198	30	patients	patient	NNS
cord-018834-4ligp4ak	198	31	with	with	IN
cord-018834-4ligp4ak	198	32	severe	severe	JJ
cord-018834-4ligp4ak	198	33	sepsis	sepsis	NN
cord-018834-4ligp4ak	198	34	[	[	-LRB-
cord-018834-4ligp4ak	198	35	1	1	CD
cord-018834-4ligp4ak	198	36	]	]	-RRB-
cord-018834-4ligp4ak	198	37	.	.	.
cord-018834-4ligp4ak	199	1	Moreover	moreover	RB
cord-018834-4ligp4ak	199	2	,	,	,
cord-018834-4ligp4ak	199	3	Guidet	Guidet	NNP
cord-018834-4ligp4ak	199	4	and	and	CC
cord-018834-4ligp4ak	199	5	colleagues	colleague	NNS
cord-018834-4ligp4ak	199	6	assessed	assess	VBD
cord-018834-4ligp4ak	199	7	the	the	DT
cord-018834-4ligp4ak	199	8	cost	cost	NN
cord-018834-4ligp4ak	199	9	-	-	HYPH
cord-018834-4ligp4ak	199	10	effectiveness	effectiveness	NN
cord-018834-4ligp4ak	199	11	of	of	IN
cord-018834-4ligp4ak	199	12	albumin	albumin	NN
cord-018834-4ligp4ak	199	13	,	,	,
cord-018834-4ligp4ak	199	14	as	as	IN
cord-018834-4ligp4ak	199	15	given	give	VBN
cord-018834-4ligp4ak	199	16	in	in	IN
cord-018834-4ligp4ak	199	17	the	the	DT
cord-018834-4ligp4ak	199	18	SAFE	safe	JJ
cord-018834-4ligp4ak	199	19	study	study	NN
cord-018834-4ligp4ak	199	20	on	on	IN
cord-018834-4ligp4ak	199	21	patients	patient	NNS
cord-018834-4ligp4ak	199	22	with	with	IN
cord-018834-4ligp4ak	199	23	severe	severe	JJ
cord-018834-4ligp4ak	199	24	sepsis	sepsis	NN
cord-018834-4ligp4ak	199	25	and	and	CC
cord-018834-4ligp4ak	199	26	septic	septic	JJ
cord-018834-4ligp4ak	199	27	shock	shock	NN
cord-018834-4ligp4ak	199	28	,	,	,
cord-018834-4ligp4ak	199	29	who	who	WP
cord-018834-4ligp4ak	199	30	were	be	VBD
cord-018834-4ligp4ak	199	31	admitted	admit	VBN
cord-018834-4ligp4ak	199	32	to	to	IN
cord-018834-4ligp4ak	199	33	1	1	CD
cord-018834-4ligp4ak	199	34	of	of	IN
cord-018834-4ligp4ak	199	35	35	35	CD
cord-018834-4ligp4ak	199	36	French	french	JJ
cord-018834-4ligp4ak	199	37	ICUs	icu	NNS
cord-018834-4ligp4ak	199	38	.	.	.
cord-018834-4ligp4ak	200	1	Based	base	VBN
cord-018834-4ligp4ak	200	2	on	on	IN
cord-018834-4ligp4ak	200	3	a	a	DT
cord-018834-4ligp4ak	200	4	presumed	presume	VBN
cord-018834-4ligp4ak	200	5	4.6	4.6	CD
cord-018834-4ligp4ak	200	6	%	%	NN
cord-018834-4ligp4ak	200	7	reduction	reduction	NN
cord-018834-4ligp4ak	200	8	in	in	IN
cord-018834-4ligp4ak	200	9	mortality	mortality	NN
cord-018834-4ligp4ak	200	10	associated	associate	VBN
cord-018834-4ligp4ak	200	11	with	with	IN
cord-018834-4ligp4ak	200	12	albumin	albumin	NN
cord-018834-4ligp4ak	200	13	therapy	therapy	NN
cord-018834-4ligp4ak	200	14	as	as	IN
cord-018834-4ligp4ak	200	15	shown	show	VBN
cord-018834-4ligp4ak	200	16	in	in	IN
cord-018834-4ligp4ak	200	17	the	the	DT
cord-018834-4ligp4ak	200	18	SAFE	safe	JJ
cord-018834-4ligp4ak	200	19	trial	trial	NN
cord-018834-4ligp4ak	200	20	,	,	,
cord-018834-4ligp4ak	200	21	513	513	CD
cord-018834-4ligp4ak	200	22	lives	life	NNS
cord-018834-4ligp4ak	200	23	were	be	VBD
cord-018834-4ligp4ak	200	24	saved	save	VBN
cord-018834-4ligp4ak	200	25	among	among	IN
cord-018834-4ligp4ak	200	26	the	the	DT
cord-018834-4ligp4ak	200	27	11,137	11,137	CD
cord-018834-4ligp4ak	200	28	patients	patient	NNS
cord-018834-4ligp4ak	200	29	included	include	VBN
cord-018834-4ligp4ak	200	30	,	,	,
cord-018834-4ligp4ak	200	31	with	with	IN
cord-018834-4ligp4ak	200	32	an	an	DT
cord-018834-4ligp4ak	200	33	estimated	estimate	VBN
cord-018834-4ligp4ak	200	34	life	life	NN
cord-018834-4ligp4ak	200	35	expectancy	expectancy	NN
cord-018834-4ligp4ak	200	36	for	for	IN
cord-018834-4ligp4ak	200	37	each	each	DT
cord-018834-4ligp4ak	200	38	life	life	NN
cord-018834-4ligp4ak	200	39	saved	save	VBN
cord-018834-4ligp4ak	200	40	of	of	IN
cord-018834-4ligp4ak	200	41	9.8	9.8	CD
cord-018834-4ligp4ak	200	42	years	year	NNS
cord-018834-4ligp4ak	200	43	.	.	.
cord-018834-4ligp4ak	201	1	Therefore	therefore	RB
cord-018834-4ligp4ak	201	2	,	,	,
cord-018834-4ligp4ak	201	3	the	the	DT
cord-018834-4ligp4ak	201	4	authors	author	NNS
cord-018834-4ligp4ak	201	5	suggested	suggest	VBD
cord-018834-4ligp4ak	201	6	that	that	IN
cord-018834-4ligp4ak	201	7	albumin	albumin	NN
cord-018834-4ligp4ak	201	8	administration	administration	NN
cord-018834-4ligp4ak	201	9	was	be	VBD
cord-018834-4ligp4ak	201	10	a	a	DT
cord-018834-4ligp4ak	201	11	cost	cost	NN
cord-018834-4ligp4ak	201	12	-	-	HYPH
cord-018834-4ligp4ak	201	13	effective	effective	JJ
cord-018834-4ligp4ak	201	14	intervention	intervention	NN
cord-018834-4ligp4ak	201	15	in	in	IN
cord-018834-4ligp4ak	201	16	patients	patient	NNS
cord-018834-4ligp4ak	201	17	with	with	IN
cord-018834-4ligp4ak	201	18	severe	severe	JJ
cord-018834-4ligp4ak	201	19	sepsis	sepsis	NN
cord-018834-4ligp4ak	201	20	or	or	CC
cord-018834-4ligp4ak	201	21	septic	septic	JJ
cord-018834-4ligp4ak	201	22	shock	shock	NN
cord-018834-4ligp4ak	201	23	[	[	-LRB-
cord-018834-4ligp4ak	201	24	4	4	CD
cord-018834-4ligp4ak	201	25	]	]	-RRB-
cord-018834-4ligp4ak	201	26	.	.	.
cord-018834-4ligp4ak	202	1	In	in	IN
cord-018834-4ligp4ak	202	2	a	a	DT
cord-018834-4ligp4ak	202	3	subsequent	subsequent	JJ
cord-018834-4ligp4ak	202	4	meta	meta	JJ
cord-018834-4ligp4ak	202	5	-	-	HYPH
cord-018834-4ligp4ak	202	6	analysis	analysis	NN
cord-018834-4ligp4ak	202	7	that	that	WDT
cord-018834-4ligp4ak	202	8	included	include	VBD
cord-018834-4ligp4ak	202	9	17	17	CD
cord-018834-4ligp4ak	202	10	studies	study	NNS
cord-018834-4ligp4ak	202	11	with	with	IN
cord-018834-4ligp4ak	202	12	randomized	randomized	JJ
cord-018834-4ligp4ak	202	13	1,977	1,977	CD
cord-018834-4ligp4ak	202	14	participants	participant	NNS
cord-018834-4ligp4ak	202	15	,	,	,
cord-018834-4ligp4ak	202	16	there	there	EX
cord-018834-4ligp4ak	202	17	were	be	VBD
cord-018834-4ligp4ak	202	18	eight	eight	CD
cord-018834-4ligp4ak	202	19	studies	study	NNS
cord-018834-4ligp4ak	202	20	that	that	WDT
cord-018834-4ligp4ak	202	21	included	include	VBD
cord-018834-4ligp4ak	202	22	only	only	RB
cord-018834-4ligp4ak	202	23	patients	patient	NNS
cord-018834-4ligp4ak	202	24	with	with	IN
cord-018834-4ligp4ak	202	25	sepsis	sepsis	NN
cord-018834-4ligp4ak	202	26	and	and	CC
cord-018834-4ligp4ak	202	27	where	where	WRB
cord-018834-4ligp4ak	202	28	patients	patient	NNS
cord-018834-4ligp4ak	202	29	were	be	VBD
cord-018834-4ligp4ak	202	30	a	a	DT
cord-018834-4ligp4ak	202	31	subgroup	subgroup	NN
cord-018834-4ligp4ak	202	32	of	of	IN
cord-018834-4ligp4ak	202	33	the	the	DT
cord-018834-4ligp4ak	202	34	study	study	NN
cord-018834-4ligp4ak	202	35	population	population	NN
cord-018834-4ligp4ak	202	36	.	.	.
cord-018834-4ligp4ak	203	1	The	the	DT
cord-018834-4ligp4ak	203	2	use	use	NN
cord-018834-4ligp4ak	203	3	of	of	IN
cord-018834-4ligp4ak	203	4	albumin	albumin	NN
cord-018834-4ligp4ak	203	5	for	for	IN
cord-018834-4ligp4ak	203	6	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	203	7	of	of	IN
cord-018834-4ligp4ak	203	8	patients	patient	NNS
cord-018834-4ligp4ak	203	9	with	with	IN
cord-018834-4ligp4ak	203	10	sepsis	sepsis	NN
cord-018834-4ligp4ak	203	11	was	be	VBD
cord-018834-4ligp4ak	203	12	associated	associate	VBN
cord-018834-4ligp4ak	203	13	with	with	IN
cord-018834-4ligp4ak	203	14	a	a	DT
cord-018834-4ligp4ak	203	15	reduced	reduce	VBN
cord-018834-4ligp4ak	203	16	mortality	mortality	NN
cord-018834-4ligp4ak	203	17	,	,	,
cord-018834-4ligp4ak	203	18	with	with	IN
cord-018834-4ligp4ak	203	19	the	the	DT
cord-018834-4ligp4ak	203	20	odds	odd	NNS
cord-018834-4ligp4ak	203	21	ratio	ratio	NN
cord-018834-4ligp4ak	203	22	of	of	IN
cord-018834-4ligp4ak	203	23	0.82	0.82	CD
cord-018834-4ligp4ak	203	24	%	%	NN
cord-018834-4ligp4ak	203	25	(	(	-LRB-
cord-018834-4ligp4ak	203	26	CI	CI	NNP
cord-018834-4ligp4ak	203	27	95	95	CD
cord-018834-4ligp4ak	203	28	%	%	NN
cord-018834-4ligp4ak	203	29	0.67	0.67	CD
cord-018834-4ligp4ak	203	30	-	-	SYM
cord-018834-4ligp4ak	203	31	1.0	1.0	CD
cord-018834-4ligp4ak	203	32	,	,	,
cord-018834-4ligp4ak	203	33	P	p	NN
cord-018834-4ligp4ak	203	34	=	=	SYM
cord-018834-4ligp4ak	203	35	.047	.047	NFP
cord-018834-4ligp4ak	203	36	)	)	-RRB-
cord-018834-4ligp4ak	203	37	[	[	-LRB-
cord-018834-4ligp4ak	203	38	1	1	CD
cord-018834-4ligp4ak	203	39	]	]	-RRB-
cord-018834-4ligp4ak	203	40	.	.	.
cord-018834-4ligp4ak	204	1	Caironi	Caironi	NNP
cord-018834-4ligp4ak	204	2	and	and	CC
cord-018834-4ligp4ak	204	3	colleagues	colleague	NNS
cord-018834-4ligp4ak	204	4	randomized	randomize	VBD
cord-018834-4ligp4ak	204	5	1,818	1,818	CD
cord-018834-4ligp4ak	204	6	patients	patient	NNS
cord-018834-4ligp4ak	204	7	with	with	IN
cord-018834-4ligp4ak	204	8	severe	severe	JJ
cord-018834-4ligp4ak	204	9	sepsis	sepsis	NN
cord-018834-4ligp4ak	204	10	in	in	IN
cord-018834-4ligp4ak	204	11	100	100	CD
cord-018834-4ligp4ak	204	12	ICUs	icu	NNS
cord-018834-4ligp4ak	204	13	to	to	TO
cord-018834-4ligp4ak	204	14	receive	receive	VB
cord-018834-4ligp4ak	204	15	either	either	CC
cord-018834-4ligp4ak	204	16	20	20	CD
cord-018834-4ligp4ak	204	17	%	%	NN
cord-018834-4ligp4ak	204	18	albumin	albumin	NN
cord-018834-4ligp4ak	204	19	and	and	CC
cord-018834-4ligp4ak	204	20	crystalloid	crystalloid	NN
cord-018834-4ligp4ak	204	21	solution	solution	NN
cord-018834-4ligp4ak	204	22	or	or	CC
cord-018834-4ligp4ak	204	23	crystalloid	crystalloid	NN
cord-018834-4ligp4ak	204	24	solution	solution	NN
cord-018834-4ligp4ak	204	25	alone	alone	RB
cord-018834-4ligp4ak	204	26	.	.	.
cord-018834-4ligp4ak	205	1	During	during	IN
cord-018834-4ligp4ak	205	2	the	the	DT
cord-018834-4ligp4ak	205	3	fi	fi	NNP
cord-018834-4ligp4ak	205	4	rst	rst	NNP
cord-018834-4ligp4ak	205	5	7	7	CD
cord-018834-4ligp4ak	205	6	days	day	NNS
cord-018834-4ligp4ak	205	7	,	,	,
cord-018834-4ligp4ak	205	8	patients	patient	NNS
cord-018834-4ligp4ak	205	9	in	in	IN
cord-018834-4ligp4ak	205	10	the	the	DT
cord-018834-4ligp4ak	205	11	albumin	albumin	NN
cord-018834-4ligp4ak	205	12	group	group	NN
cord-018834-4ligp4ak	205	13	had	have	VBD
cord-018834-4ligp4ak	205	14	a	a	DT
cord-018834-4ligp4ak	205	15	higher	high	JJR
cord-018834-4ligp4ak	205	16	mean	mean	JJ
cord-018834-4ligp4ak	205	17	arterial	arterial	JJ
cord-018834-4ligp4ak	205	18	pressure	pressure	NN
cord-018834-4ligp4ak	205	19	and	and	CC
cord-018834-4ligp4ak	205	20	lower	low	JJR
cord-018834-4ligp4ak	205	21	net	net	JJ
cord-018834-4ligp4ak	205	22	fl	fl	NNP
cord-018834-4ligp4ak	205	23	uid	uid	NN
cord-018834-4ligp4ak	205	24	balance	balance	NN
cord-018834-4ligp4ak	205	25	(	(	-LRB-
cord-018834-4ligp4ak	205	26	P	p	NN
cord-018834-4ligp4ak	205	27	<	<	XX
cord-018834-4ligp4ak	205	28	0.001	0.001	CD
cord-018834-4ligp4ak	205	29	)	)	-RRB-
cord-018834-4ligp4ak	205	30	.	.	.
cord-018834-4ligp4ak	206	1	At	at	IN
cord-018834-4ligp4ak	206	2	28	28	CD
cord-018834-4ligp4ak	206	3	days	day	NNS
cord-018834-4ligp4ak	206	4	the	the	DT
cord-018834-4ligp4ak	206	5	mortality	mortality	NN
cord-018834-4ligp4ak	206	6	rate	rate	NN
cord-018834-4ligp4ak	206	7	was	be	VBD
cord-018834-4ligp4ak	206	8	31.8	31.8	CD
cord-018834-4ligp4ak	206	9	%	%	NN
cord-018834-4ligp4ak	206	10	in	in	IN
cord-018834-4ligp4ak	206	11	the	the	DT
cord-018834-4ligp4ak	206	12	albumin	albumin	NN
cord-018834-4ligp4ak	206	13	group	group	NN
cord-018834-4ligp4ak	206	14	and	and	CC
cord-018834-4ligp4ak	206	15	32.0	32.0	CD
cord-018834-4ligp4ak	206	16	%	%	NN
cord-018834-4ligp4ak	206	17	in	in	IN
cord-018834-4ligp4ak	206	18	the	the	DT
cord-018834-4ligp4ak	206	19	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	206	20	group	group	NN
cord-018834-4ligp4ak	206	21	.	.	.
cord-018834-4ligp4ak	207	1	At	at	IN
cord-018834-4ligp4ak	207	2	90	90	CD
cord-018834-4ligp4ak	207	3	days	day	NNS
cord-018834-4ligp4ak	207	4	the	the	DT
cord-018834-4ligp4ak	207	5	mortality	mortality	NN
cord-018834-4ligp4ak	207	6	rate	rate	NN
cord-018834-4ligp4ak	207	7	was	be	VBD
cord-018834-4ligp4ak	207	8	41.1	41.1	CD
cord-018834-4ligp4ak	207	9	%	%	NN
cord-018834-4ligp4ak	207	10	in	in	IN
cord-018834-4ligp4ak	207	11	the	the	DT
cord-018834-4ligp4ak	207	12	albumin	albumin	NN
cord-018834-4ligp4ak	207	13	group	group	NN
cord-018834-4ligp4ak	207	14	and	and	CC
cord-018834-4ligp4ak	207	15	43.6	43.6	CD
cord-018834-4ligp4ak	207	16	%	%	NN
cord-018834-4ligp4ak	207	17	in	in	IN
cord-018834-4ligp4ak	207	18	the	the	DT
cord-018834-4ligp4ak	207	19	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	207	20	group	group	NN
cord-018834-4ligp4ak	207	21	.	.	.
cord-018834-4ligp4ak	208	1	However	however	RB
cord-018834-4ligp4ak	208	2	,	,	,
cord-018834-4ligp4ak	208	3	there	there	EX
cord-018834-4ligp4ak	208	4	was	be	VBD
cord-018834-4ligp4ak	208	5	improved	improve	VBN
cord-018834-4ligp4ak	208	6	survival	survival	NN
cord-018834-4ligp4ak	208	7	associated	associate	VBN
cord-018834-4ligp4ak	208	8	with	with	IN
cord-018834-4ligp4ak	208	9	albumin	albumin	NN
cord-018834-4ligp4ak	208	10	in	in	IN
cord-018834-4ligp4ak	208	11	patients	patient	NNS
cord-018834-4ligp4ak	208	12	with	with	IN
cord-018834-4ligp4ak	208	13	septic	septic	JJ
cord-018834-4ligp4ak	208	14	shock	shock	NN
cord-018834-4ligp4ak	208	15	(	(	-LRB-
cord-018834-4ligp4ak	208	16	1,121	1,121	CD
cord-018834-4ligp4ak	208	17	patients	patient	NNS
cord-018834-4ligp4ak	208	18	;	;	:
cord-018834-4ligp4ak	208	19	90-day	90-day	CD
cord-018834-4ligp4ak	208	20	mortality	mortality	NN
cord-018834-4ligp4ak	208	21	,	,	,
cord-018834-4ligp4ak	208	22	43.6	43.6	CD
cord-018834-4ligp4ak	208	23	%	%	NN
cord-018834-4ligp4ak	208	24	in	in	IN
cord-018834-4ligp4ak	208	25	the	the	DT
cord-018834-4ligp4ak	208	26	albumin	albumin	NN
cord-018834-4ligp4ak	208	27	group	group	NN
cord-018834-4ligp4ak	208	28	vs.	vs.	IN
cord-018834-4ligp4ak	208	29	49.9	49.9	CD
cord-018834-4ligp4ak	208	30	%	%	NN
cord-018834-4ligp4ak	208	31	in	in	IN
cord-018834-4ligp4ak	208	32	the	the	DT
cord-018834-4ligp4ak	208	33	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	208	34	group	group	NN
cord-018834-4ligp4ak	208	35	;	;	:
cord-018834-4ligp4ak	208	36	relative	relative	JJ
cord-018834-4ligp4ak	208	37	risk	risk	NN
cord-018834-4ligp4ak	208	38	0.87	0.87	CD
cord-018834-4ligp4ak	208	39	;	;	:
cord-018834-4ligp4ak	208	40	95	95	CD
cord-018834-4ligp4ak	208	41	%	%	NN
cord-018834-4ligp4ak	208	42	CI	CI	NNP
cord-018834-4ligp4ak	208	43	,	,	,
cord-018834-4ligp4ak	208	44	0.77	0.77	CD
cord-018834-4ligp4ak	208	45	-	-	SYM
cord-018834-4ligp4ak	208	46	0.99	0.99	CD
cord-018834-4ligp4ak	208	47	;	;	:
cord-018834-4ligp4ak	208	48	P	p	NN
cord-018834-4ligp4ak	208	49	=	=	SYM
cord-018834-4ligp4ak	208	50	0.03	0.03	CD
cord-018834-4ligp4ak	208	51	)	)	-RRB-
cord-018834-4ligp4ak	208	52	[	[	-LRB-
cord-018834-4ligp4ak	208	53	43	43	CD
cord-018834-4ligp4ak	208	54	]	]	-RRB-
cord-018834-4ligp4ak	208	55	.	.	.
cord-018834-4ligp4ak	209	1	The	the	DT
cord-018834-4ligp4ak	209	2	results	result	NNS
cord-018834-4ligp4ak	209	3	of	of	IN
cord-018834-4ligp4ak	209	4	a	a	DT
cord-018834-4ligp4ak	209	5	recent	recent	JJ
cord-018834-4ligp4ak	209	6	meta	meta	JJ
cord-018834-4ligp4ak	209	7	-	-	HYPH
cord-018834-4ligp4ak	209	8	analysis	analysis	NN
cord-018834-4ligp4ak	209	9	,	,	,
cord-018834-4ligp4ak	209	10	which	which	WDT
cord-018834-4ligp4ak	209	11	included	include	VBD
cord-018834-4ligp4ak	209	12	14	14	CD
cord-018834-4ligp4ak	209	13	studies	study	NNS
cord-018834-4ligp4ak	209	14	(	(	-LRB-
cord-018834-4ligp4ak	209	15	18,916	18,916	CD
cord-018834-4ligp4ak	209	16	patients	patient	NNS
cord-018834-4ligp4ak	209	17	with	with	IN
cord-018834-4ligp4ak	209	18	sepsis	sepsis	NN
cord-018834-4ligp4ak	209	19	)	)	-RRB-
cord-018834-4ligp4ak	209	20	,	,	,
cord-018834-4ligp4ak	209	21	showed	show	VBD
cord-018834-4ligp4ak	209	22	that	that	IN
cord-018834-4ligp4ak	209	23	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	209	24	with	with	IN
cord-018834-4ligp4ak	209	25	balanced	balanced	JJ
cord-018834-4ligp4ak	209	26	crystalloids	crystalloid	NNS
cord-018834-4ligp4ak	209	27	or	or	CC
cord-018834-4ligp4ak	209	28	albumin	albumin	NN
cord-018834-4ligp4ak	209	29	in	in	IN
cord-018834-4ligp4ak	209	30	patients	patient	NNS
cord-018834-4ligp4ak	209	31	with	with	IN
cord-018834-4ligp4ak	209	32	sepsis	sepsis	NN
cord-018834-4ligp4ak	209	33	seems	seem	VBZ
cord-018834-4ligp4ak	209	34	to	to	TO
cord-018834-4ligp4ak	209	35	be	be	VB
cord-018834-4ligp4ak	209	36	associated	associate	VBN
cord-018834-4ligp4ak	209	37	with	with	IN
cord-018834-4ligp4ak	209	38	reduced	reduce	VBN
cord-018834-4ligp4ak	209	39	mortality	mortality	NN
cord-018834-4ligp4ak	209	40	[	[	-LRB-
cord-018834-4ligp4ak	209	41	44	44	CD
cord-018834-4ligp4ak	209	42	]	]	-RRB-
cord-018834-4ligp4ak	209	43	.	.	.
cord-018834-4ligp4ak	210	1	Furthermore	furthermore	RB
cord-018834-4ligp4ak	210	2	,	,	,
cord-018834-4ligp4ak	210	3	the	the	DT
cord-018834-4ligp4ak	210	4	improved	improve	VBN
cord-018834-4ligp4ak	210	5	survival	survival	NN
cord-018834-4ligp4ak	210	6	associated	associate	VBN
cord-018834-4ligp4ak	210	7	with	with	IN
cord-018834-4ligp4ak	210	8	albumin	albumin	NN
cord-018834-4ligp4ak	210	9	in	in	IN
cord-018834-4ligp4ak	210	10	patients	patient	NNS
cord-018834-4ligp4ak	210	11	with	with	IN
cord-018834-4ligp4ak	210	12	septic	septic	JJ
cord-018834-4ligp4ak	210	13	shock	shock	NN
cord-018834-4ligp4ak	210	14	was	be	VBD
cord-018834-4ligp4ak	210	15	confi	confi	NNP
cord-018834-4ligp4ak	210	16	rmed	rme	VBN
cord-018834-4ligp4ak	210	17	in	in	IN
cord-018834-4ligp4ak	210	18	a	a	DT
cord-018834-4ligp4ak	210	19	recent	recent	JJ
cord-018834-4ligp4ak	210	20	metaanalysis	metaanalysis	NN
cord-018834-4ligp4ak	210	21	.	.	.
cord-018834-4ligp4ak	211	1	In	in	IN
cord-018834-4ligp4ak	211	2	this	this	DT
cord-018834-4ligp4ak	211	3	meta	meta	JJ
cord-018834-4ligp4ak	211	4	-	-	HYPH
cord-018834-4ligp4ak	211	5	analysis	analysis	NN
cord-018834-4ligp4ak	211	6	,	,	,
cord-018834-4ligp4ak	211	7	3,658	3,658	CD
cord-018834-4ligp4ak	211	8	with	with	IN
cord-018834-4ligp4ak	211	9	severe	severe	JJ
cord-018834-4ligp4ak	211	10	sepsis	sepsis	NN
cord-018834-4ligp4ak	211	11	and	and	CC
cord-018834-4ligp4ak	211	12	2,180	2,180	CD
cord-018834-4ligp4ak	211	13	with	with	IN
cord-018834-4ligp4ak	211	14	septic	septic	JJ
cord-018834-4ligp4ak	211	15	shock	shock	NN
cord-018834-4ligp4ak	211	16	patients	patient	NNS
cord-018834-4ligp4ak	211	17	were	be	VBD
cord-018834-4ligp4ak	211	18	included	include	VBN
cord-018834-4ligp4ak	211	19	in	in	IN
cord-018834-4ligp4ak	211	20	the	the	DT
cord-018834-4ligp4ak	211	21	analysis	analysis	NN
cord-018834-4ligp4ak	211	22	[	[	-LRB-
cord-018834-4ligp4ak	211	23	45	45	CD
cord-018834-4ligp4ak	211	24	]	]	-RRB-
cord-018834-4ligp4ak	211	25	.	.	.
cord-018834-4ligp4ak	212	1	Compared	compare	VBN
cord-018834-4ligp4ak	212	2	with	with	IN
cord-018834-4ligp4ak	212	3	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	212	4	,	,	,
cord-018834-4ligp4ak	212	5	a	a	DT
cord-018834-4ligp4ak	212	6	trend	trend	NN
cord-018834-4ligp4ak	212	7	toward	toward	IN
cord-018834-4ligp4ak	212	8	reduced	reduce	VBN
cord-018834-4ligp4ak	212	9	90-day	90-day	CD
cord-018834-4ligp4ak	212	10	mortality	mortality	NN
cord-018834-4ligp4ak	212	11	was	be	VBD
cord-018834-4ligp4ak	212	12	observed	observe	VBN
cord-018834-4ligp4ak	212	13	in	in	IN
cord-018834-4ligp4ak	212	14	severe	severe	JJ
cord-018834-4ligp4ak	212	15	sepsis	sepsis	NN
cord-018834-4ligp4ak	212	16	patients	patient	NNS
cord-018834-4ligp4ak	212	17	resuscitated	resuscitate	VBD
cord-018834-4ligp4ak	212	18	with	with	IN
cord-018834-4ligp4ak	212	19	albumin	albumin	NN
cord-018834-4ligp4ak	212	20	(	(	-LRB-
cord-018834-4ligp4ak	212	21	OR	or	CC
cord-018834-4ligp4ak	212	22	0.88	0.88	CD
cord-018834-4ligp4ak	212	23	;	;	:
cord-018834-4ligp4ak	212	24	95	95	CD
cord-018834-4ligp4ak	212	25	%	%	NN
cord-018834-4ligp4ak	212	26	CI	ci	NN
cord-018834-4ligp4ak	212	27	,	,	,
cord-018834-4ligp4ak	212	28	0.76	0.76	CD
cord-018834-4ligp4ak	212	29	-	-	HYPH
cord-018834-4ligp4ak	212	30	1.01	1.01	CD
cord-018834-4ligp4ak	212	31	;	;	:
cord-018834-4ligp4ak	212	32	P	p	NN
cord-018834-4ligp4ak	212	33	=	=	SYM
cord-018834-4ligp4ak	212	34	0.08	0.08	CD
cord-018834-4ligp4ak	212	35	)	)	-RRB-
cord-018834-4ligp4ak	212	36	.	.	.
cord-018834-4ligp4ak	213	1	However	however	RB
cord-018834-4ligp4ak	213	2	,	,	,
cord-018834-4ligp4ak	213	3	in	in	IN
cord-018834-4ligp4ak	213	4	septic	septic	JJ
cord-018834-4ligp4ak	213	5	shock	shock	NN
cord-018834-4ligp4ak	213	6	patients	patient	VBZ
cord-018834-4ligp4ak	213	7	the	the	DT
cord-018834-4ligp4ak	213	8	use	use	NN
cord-018834-4ligp4ak	213	9	of	of	IN
cord-018834-4ligp4ak	213	10	albumin	albumin	NN
cord-018834-4ligp4ak	213	11	for	for	IN
cord-018834-4ligp4ak	213	12	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	213	13	signifi	signifi	NNP
cord-018834-4ligp4ak	213	14	cantly	cantly	NNP
cord-018834-4ligp4ak	213	15	decreased	decrease	VBD
cord-018834-4ligp4ak	213	16	90-day	90-day	CD
cord-018834-4ligp4ak	213	17	mortality	mortality	NN
cord-018834-4ligp4ak	213	18	(	(	-LRB-
cord-018834-4ligp4ak	213	19	OR	or	CC
cord-018834-4ligp4ak	213	20	0.81	0.81	CD
cord-018834-4ligp4ak	213	21	;	;	:
cord-018834-4ligp4ak	213	22	95	95	CD
cord-018834-4ligp4ak	213	23	%	%	NN
cord-018834-4ligp4ak	213	24	CI	CI	NNP
cord-018834-4ligp4ak	213	25	,	,	,
cord-018834-4ligp4ak	213	26	0.67	0.67	CD
cord-018834-4ligp4ak	213	27	-	-	SYM
cord-018834-4ligp4ak	213	28	0.97	0.97	CD
cord-018834-4ligp4ak	213	29	;	;	:
cord-018834-4ligp4ak	213	30	P	p	NN
cord-018834-4ligp4ak	213	31	=	=	SYM
cord-018834-4ligp4ak	213	32	0.03	0.03	CD
cord-018834-4ligp4ak	213	33	)	)	-RRB-
cord-018834-4ligp4ak	213	34	[	[	-LRB-
cord-018834-4ligp4ak	213	35	45	45	CD
cord-018834-4ligp4ak	213	36	]	]	-RRB-
cord-018834-4ligp4ak	213	37	.	.	.
cord-018834-4ligp4ak	214	1	Albumin	albumin	NN
cord-018834-4ligp4ak	214	2	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	214	3	in	in	IN
cord-018834-4ligp4ak	214	4	sepsis	sepsis	NN
cord-018834-4ligp4ak	214	5	has	have	VBZ
cord-018834-4ligp4ak	214	6	a	a	DT
cord-018834-4ligp4ak	214	7	unique	unique	JJ
cord-018834-4ligp4ak	214	8	feature	feature	NN
cord-018834-4ligp4ak	214	9	compared	compare	VBN
cord-018834-4ligp4ak	214	10	to	to	IN
cord-018834-4ligp4ak	214	11	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	214	12	as	as	IN
cord-018834-4ligp4ak	214	13	its	-PRON-	PRP$
cord-018834-4ligp4ak	214	14	effectiveness	effectiveness	NN
cord-018834-4ligp4ak	214	15	as	as	IN
cord-018834-4ligp4ak	214	16	a	a	DT
cord-018834-4ligp4ak	214	17	plasma	plasma	NN
cord-018834-4ligp4ak	214	18	-	-	HYPH
cord-018834-4ligp4ak	214	19	volume	volume	NN
cord-018834-4ligp4ak	214	20	expander	expander	NN
cord-018834-4ligp4ak	214	21	does	do	VBZ
cord-018834-4ligp4ak	214	22	not	not	RB
cord-018834-4ligp4ak	214	23	change	change	VB
cord-018834-4ligp4ak	214	24	in	in	IN
cord-018834-4ligp4ak	214	25	pathophysiological	pathophysiological	JJ
cord-018834-4ligp4ak	214	26	conditions	condition	NNS
cord-018834-4ligp4ak	214	27	associated	associate	VBN
cord-018834-4ligp4ak	214	28	with	with	IN
cord-018834-4ligp4ak	214	29	increased	increase	VBN
cord-018834-4ligp4ak	214	30	microvascular	microvascular	JJ
cord-018834-4ligp4ak	214	31	permeability	permeability	NN
cord-018834-4ligp4ak	214	32	as	as	IN
cord-018834-4ligp4ak	214	33	sepsis	sepsis	NN
cord-018834-4ligp4ak	214	34	.	.	.
cord-018834-4ligp4ak	215	1	In	in	IN
cord-018834-4ligp4ak	215	2	addition	addition	NN
cord-018834-4ligp4ak	215	3	,	,	,
cord-018834-4ligp4ak	215	4	in	in	IN
cord-018834-4ligp4ak	215	5	severe	severe	JJ
cord-018834-4ligp4ak	215	6	sepsis	sepsis	NN
cord-018834-4ligp4ak	215	7	the	the	DT
cord-018834-4ligp4ak	215	8	ratio	ratio	NN
cord-018834-4ligp4ak	215	9	of	of	IN
cord-018834-4ligp4ak	215	10	albumin	albumin	NN
cord-018834-4ligp4ak	215	11	to	to	IN
cord-018834-4ligp4ak	215	12	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	215	13	for	for	IN
cord-018834-4ligp4ak	215	14	equal	equal	JJ
cord-018834-4ligp4ak	215	15	plasma	plasma	NN
cord-018834-4ligp4ak	215	16	volume	volume	NN
cord-018834-4ligp4ak	215	17	expansion	expansion	NN
cord-018834-4ligp4ak	215	18	is	be	VBZ
cord-018834-4ligp4ak	215	19	approximately	approximately	RB
cord-018834-4ligp4ak	215	20	1	1	CD
cord-018834-4ligp4ak	215	21	-	-	SYM
cord-018834-4ligp4ak	215	22	4.5	4.5	CD
cord-018834-4ligp4ak	215	23	[	[	-LRB-
cord-018834-4ligp4ak	215	24	46	46	CD
cord-018834-4ligp4ak	215	25	]	]	-RRB-
cord-018834-4ligp4ak	215	26	.	.	.
cord-018834-4ligp4ak	216	1	The	the	DT
cord-018834-4ligp4ak	216	2	use	use	NN
cord-018834-4ligp4ak	216	3	of	of	IN
cord-018834-4ligp4ak	216	4	intravenous	intravenous	JJ
cord-018834-4ligp4ak	216	5	albumin	albumin	NN
cord-018834-4ligp4ak	216	6	in	in	IN
cord-018834-4ligp4ak	216	7	addition	addition	NN
cord-018834-4ligp4ak	216	8	to	to	IN
cord-018834-4ligp4ak	216	9	antibiotics	antibiotic	NNS
cord-018834-4ligp4ak	216	10	in	in	IN
cord-018834-4ligp4ak	216	11	patients	patient	NNS
cord-018834-4ligp4ak	216	12	with	with	IN
cord-018834-4ligp4ak	216	13	cirrhosis	cirrhosis	NN
cord-018834-4ligp4ak	216	14	and	and	CC
cord-018834-4ligp4ak	216	15	spontaneous	spontaneous	JJ
cord-018834-4ligp4ak	216	16	bacterial	bacterial	JJ
cord-018834-4ligp4ak	216	17	peritonitis	peritonitis	NN
cord-018834-4ligp4ak	216	18	reduced	reduce	VBD
cord-018834-4ligp4ak	216	19	the	the	DT
cord-018834-4ligp4ak	216	20	incidence	incidence	NN
cord-018834-4ligp4ak	216	21	of	of	IN
cord-018834-4ligp4ak	216	22	renal	renal	JJ
cord-018834-4ligp4ak	216	23	impairment	impairment	NN
cord-018834-4ligp4ak	216	24	,	,	,
cord-018834-4ligp4ak	216	25	death	death	NN
cord-018834-4ligp4ak	216	26	,	,	,
cord-018834-4ligp4ak	216	27	and	and	CC
cord-018834-4ligp4ak	216	28	paracentesis	paracentesis	NN
cord-018834-4ligp4ak	216	29	-	-	HYPH
cord-018834-4ligp4ak	216	30	induced	induce	VBN
cord-018834-4ligp4ak	216	31	circulatory	circulatory	JJ
cord-018834-4ligp4ak	216	32	collapse	collapse	NN
cord-018834-4ligp4ak	216	33	in	in	IN
cord-018834-4ligp4ak	216	34	comparison	comparison	NN
cord-018834-4ligp4ak	216	35	with	with	IN
cord-018834-4ligp4ak	216	36	treatment	treatment	NN
cord-018834-4ligp4ak	216	37	with	with	IN
cord-018834-4ligp4ak	216	38	an	an	DT
cord-018834-4ligp4ak	216	39	antibiotic	antibiotic	NN
cord-018834-4ligp4ak	216	40	alone	alone	RB
cord-018834-4ligp4ak	216	41	[	[	-LRB-
cord-018834-4ligp4ak	216	42	47	47	CD
cord-018834-4ligp4ak	216	43	,	,	,
cord-018834-4ligp4ak	216	44	48	48	CD
cord-018834-4ligp4ak	216	45	]	]	-RRB-
cord-018834-4ligp4ak	216	46	.	.	.
cord-018834-4ligp4ak	217	1	In	in	IN
cord-018834-4ligp4ak	217	2	patients	patient	NNS
cord-018834-4ligp4ak	217	3	with	with	IN
cord-018834-4ligp4ak	217	4	acute	acute	JJ
cord-018834-4ligp4ak	217	5	respiratory	respiratory	JJ
cord-018834-4ligp4ak	217	6	distress	distress	NN
cord-018834-4ligp4ak	217	7	syndrome	syndrome	NN
cord-018834-4ligp4ak	217	8	,	,	,
cord-018834-4ligp4ak	217	9	the	the	DT
cord-018834-4ligp4ak	217	10	use	use	NN
cord-018834-4ligp4ak	217	11	of	of	IN
cord-018834-4ligp4ak	217	12	albumin	albumin	NN
cord-018834-4ligp4ak	217	13	improved	improve	VBN
cord-018834-4ligp4ak	217	14	oxygenation	oxygenation	NN
cord-018834-4ligp4ak	217	15	but	but	CC
cord-018834-4ligp4ak	217	16	did	do	VBD
cord-018834-4ligp4ak	217	17	not	not	RB
cord-018834-4ligp4ak	217	18	affect	affect	VB
cord-018834-4ligp4ak	217	19	mortality	mortality	NN
cord-018834-4ligp4ak	217	20	[	[	-LRB-
cord-018834-4ligp4ak	217	21	49	49	CD
cord-018834-4ligp4ak	217	22	]	]	-RRB-
cord-018834-4ligp4ak	217	23	.	.	.
cord-018834-4ligp4ak	218	1	The	the	DT
cord-018834-4ligp4ak	218	2	only	only	JJ
cord-018834-4ligp4ak	218	3	exception	exception	NN
cord-018834-4ligp4ak	218	4	for	for	IN
cord-018834-4ligp4ak	218	5	the	the	DT
cord-018834-4ligp4ak	218	6	benefi	benefi	NNP
cord-018834-4ligp4ak	218	7	t	t	NN
cord-018834-4ligp4ak	218	8	of	of	IN
cord-018834-4ligp4ak	218	9	using	use	VBG
cord-018834-4ligp4ak	218	10	albumin	albumin	NN
cord-018834-4ligp4ak	218	11	in	in	IN
cord-018834-4ligp4ak	218	12	patients	patient	NNS
cord-018834-4ligp4ak	218	13	with	with	IN
cord-018834-4ligp4ak	218	14	sepsis	sepsis	NN
cord-018834-4ligp4ak	218	15	was	be	VBD
cord-018834-4ligp4ak	218	16	shown	show	VBN
cord-018834-4ligp4ak	218	17	in	in	IN
cord-018834-4ligp4ak	218	18	the	the	DT
cord-018834-4ligp4ak	218	19	Fluid	Fluid	NNP
cord-018834-4ligp4ak	218	20	Expansion	Expansion	NNP
cord-018834-4ligp4ak	218	21	as	as	IN
cord-018834-4ligp4ak	218	22	Supportive	supportive	JJ
cord-018834-4ligp4ak	218	23	Therapy	Therapy	NNP
cord-018834-4ligp4ak	218	24	(	(	-LRB-
cord-018834-4ligp4ak	218	25	FEAST	FEAST	NNP
cord-018834-4ligp4ak	218	26	)	)	-RRB-
cord-018834-4ligp4ak	218	27	trial	trial	NN
cord-018834-4ligp4ak	218	28	as	as	IN
cord-018834-4ligp4ak	218	29	evidenced	evidence	VBN
cord-018834-4ligp4ak	218	30	in	in	IN
cord-018834-4ligp4ak	218	31	increasing	increase	VBG
cord-018834-4ligp4ak	218	32	mortality	mortality	NN
cord-018834-4ligp4ak	218	33	with	with	IN
cord-018834-4ligp4ak	218	34	the	the	DT
cord-018834-4ligp4ak	218	35	use	use	NN
cord-018834-4ligp4ak	218	36	of	of	IN
cord-018834-4ligp4ak	218	37	albumin	albumin	NN
cord-018834-4ligp4ak	218	38	and	and	CC
cord-018834-4ligp4ak	218	39	saline	saline	NN
cord-018834-4ligp4ak	218	40	boluses	bolus	NNS
cord-018834-4ligp4ak	218	41	compared	compare	VBN
cord-018834-4ligp4ak	218	42	to	to	IN
cord-018834-4ligp4ak	218	43	no	no	DT
cord-018834-4ligp4ak	218	44	bolus	bolus	NN
cord-018834-4ligp4ak	218	45	(	(	-LRB-
cord-018834-4ligp4ak	218	46	control	control	NNP
cord-018834-4ligp4ak	218	47	group	group	NN
cord-018834-4ligp4ak	218	48	)	)	-RRB-
cord-018834-4ligp4ak	218	49	in	in	IN
cord-018834-4ligp4ak	218	50	pediatric	pediatric	JJ
cord-018834-4ligp4ak	218	51	patients	patient	NNS
cord-018834-4ligp4ak	218	52	infected	infect	VBN
cord-018834-4ligp4ak	218	53	with	with	IN
cord-018834-4ligp4ak	218	54	malaria	malaria	NN
cord-018834-4ligp4ak	218	55	in	in	IN
cord-018834-4ligp4ak	218	56	eastern	eastern	JJ
cord-018834-4ligp4ak	218	57	African	african	JJ
cord-018834-4ligp4ak	218	58	countries	country	NNS
cord-018834-4ligp4ak	218	59	.	.	.
cord-018834-4ligp4ak	219	1	The	the	DT
cord-018834-4ligp4ak	219	2	bolus	bolus	NN
cord-018834-4ligp4ak	219	3	-	-	HYPH
cord-018834-4ligp4ak	219	4	therapy	therapy	NN
cord-018834-4ligp4ak	219	5	-	-	HYPH
cord-018834-4ligp4ak	219	6	induced	induce	VBN
cord-018834-4ligp4ak	219	7	hypervolemia	hypervolemia	NN
cord-018834-4ligp4ak	219	8	by	by	IN
cord-018834-4ligp4ak	219	9	albumin	albumin	NN
cord-018834-4ligp4ak	219	10	and	and	CC
cord-018834-4ligp4ak	219	11	saline	saline	NN
cord-018834-4ligp4ak	219	12	boluses	bolus	NNS
cord-018834-4ligp4ak	219	13	in	in	IN
cord-018834-4ligp4ak	219	14	those	those	DT
cord-018834-4ligp4ak	219	15	patients	patient	NNS
cord-018834-4ligp4ak	219	16	could	could	MD
cord-018834-4ligp4ak	219	17	explain	explain	VB
cord-018834-4ligp4ak	219	18	the	the	DT
cord-018834-4ligp4ak	219	19	increased	increase	VBN
cord-018834-4ligp4ak	219	20	mortality	mortality	NN
cord-018834-4ligp4ak	219	21	in	in	IN
cord-018834-4ligp4ak	219	22	this	this	DT
cord-018834-4ligp4ak	219	23	study	study	NN
cord-018834-4ligp4ak	219	24	compared	compare	VBN
cord-018834-4ligp4ak	219	25	to	to	TO
cord-018834-4ligp4ak	219	26	control	control	VB
cord-018834-4ligp4ak	219	27	group	group	NN
cord-018834-4ligp4ak	219	28	[	[	-LRB-
cord-018834-4ligp4ak	219	29	50	50	CD
cord-018834-4ligp4ak	219	30	]	]	-RRB-
cord-018834-4ligp4ak	219	31	.	.	.
cord-018834-4ligp4ak	220	1	Human	human	JJ
cord-018834-4ligp4ak	220	2	serum	serum	NN
cord-018834-4ligp4ak	220	3	albumin	albumin	NN
cord-018834-4ligp4ak	220	4	is	be	VBZ
cord-018834-4ligp4ak	220	5	a	a	DT
cord-018834-4ligp4ak	220	6	unique	unique	JJ
cord-018834-4ligp4ak	220	7	pleiotropic	pleiotropic	JJ
cord-018834-4ligp4ak	220	8	protein	protein	NN
cord-018834-4ligp4ak	220	9	with	with	IN
cord-018834-4ligp4ak	220	10	neuroprotective	neuroprotective	JJ
cord-018834-4ligp4ak	220	11	properties	property	NNS
cord-018834-4ligp4ak	220	12	.	.	.
cord-018834-4ligp4ak	221	1	Rats	rat	NNS
cord-018834-4ligp4ak	221	2	received	receive	VBD
cord-018834-4ligp4ak	221	3	2-h	2-h	CD
cord-018834-4ligp4ak	221	4	middle	middle	JJ
cord-018834-4ligp4ak	221	5	cerebral	cerebral	JJ
cord-018834-4ligp4ak	221	6	artery	artery	NN
cord-018834-4ligp4ak	221	7	occlusion	occlusion	NN
cord-018834-4ligp4ak	221	8	(	(	-LRB-
cord-018834-4ligp4ak	221	9	MCAO	MCAO	NNP
cord-018834-4ligp4ak	221	10	)	)	-RRB-
cord-018834-4ligp4ak	221	11	and	and	CC
cord-018834-4ligp4ak	221	12	were	be	VBD
cord-018834-4ligp4ak	221	13	treated	treat	VBN
cord-018834-4ligp4ak	221	14	with	with	IN
cord-018834-4ligp4ak	221	15	human	human	JJ
cord-018834-4ligp4ak	221	16	albumin	albumin	NN
cord-018834-4ligp4ak	221	17	or	or	CC
cord-018834-4ligp4ak	221	18	saline	saline	NN
cord-018834-4ligp4ak	221	19	after	after	IN
cord-018834-4ligp4ak	221	20	30	30	CD
cord-018834-4ligp4ak	221	21	min	min	NN
cord-018834-4ligp4ak	221	22	of	of	IN
cord-018834-4ligp4ak	221	23	recirculation	recirculation	NN
cord-018834-4ligp4ak	221	24	.	.	.
cord-018834-4ligp4ak	222	1	The	the	DT
cord-018834-4ligp4ak	222	2	cortical	cortical	JJ
cord-018834-4ligp4ak	222	3	blood	blood	NN
cord-018834-4ligp4ak	222	4	vessels	vessel	NNS
cord-018834-4ligp4ak	222	5	were	be	VBD
cord-018834-4ligp4ak	222	6	examined	examine	VBN
cord-018834-4ligp4ak	222	7	afterward	afterward	RB
cord-018834-4ligp4ak	222	8	by	by	IN
cord-018834-4ligp4ak	222	9	laser	laser	NN
cord-018834-4ligp4ak	222	10	-	-	HYPH
cord-018834-4ligp4ak	222	11	Doppler	doppler	NN
cord-018834-4ligp4ak	222	12	perfusion	perfusion	NN
cord-018834-4ligp4ak	222	13	imaging	imaging	NN
cord-018834-4ligp4ak	222	14	(	(	-LRB-
cord-018834-4ligp4ak	222	15	LDPI	LDPI	NNP
cord-018834-4ligp4ak	222	16	)	)	-RRB-
cord-018834-4ligp4ak	222	17	.	.	.
cord-018834-4ligp4ak	223	1	Albumin	albumin	NN
cord-018834-4ligp4ak	223	2	therapy	therapy	NN
cord-018834-4ligp4ak	223	3	resulted	result	VBD
cord-018834-4ligp4ak	223	4	in	in	IN
cord-018834-4ligp4ak	223	5	signifi	signifi	NNP
cord-018834-4ligp4ak	223	6	ca	can	MD
cord-018834-4ligp4ak	223	7	nt	not	RB
cord-018834-4ligp4ak	223	8	increases	increase	NNS
cord-018834-4ligp4ak	223	9	in	in	IN
cord-018834-4ligp4ak	223	10	arteriolar	arteriolar	JJ
cord-018834-4ligp4ak	223	11	diameter	diameter	NN
cord-018834-4ligp4ak	223	12	,	,	,
cord-018834-4ligp4ak	223	13	and	and	CC
cord-018834-4ligp4ak	223	14	reversing	reverse	VBG
cord-018834-4ligp4ak	223	15	stagnation	stagnation	NN
cord-018834-4ligp4ak	223	16	,	,	,
cord-018834-4ligp4ak	223	17	thrombosis	thrombosis	NN
cord-018834-4ligp4ak	223	18	,	,	,
cord-018834-4ligp4ak	223	19	and	and	CC
cord-018834-4ligp4ak	223	20	corpuscular	corpuscular	JJ
cord-018834-4ligp4ak	223	21	adherence	adherence	NN
cord-018834-4ligp4ak	223	22	within	within	IN
cord-018834-4ligp4ak	223	23	cortical	cortical	JJ
cord-018834-4ligp4ak	223	24	venules	venule	NNS
cord-018834-4ligp4ak	223	25	in	in	IN
cord-018834-4ligp4ak	223	26	the	the	DT
cord-018834-4ligp4ak	223	27	reperfusion	reperfusion	NN
cord-018834-4ligp4ak	223	28	phase	phase	NN
cord-018834-4ligp4ak	223	29	after	after	IN
cord-018834-4ligp4ak	223	30	focal	focal	JJ
cord-018834-4ligp4ak	223	31	ischemia	ischemia	NN
cord-018834-4ligp4ak	223	32	[	[	-LRB-
cord-018834-4ligp4ak	223	33	51	51	CD
cord-018834-4ligp4ak	223	34	]	]	-RRB-
cord-018834-4ligp4ak	223	35	.	.	.
cord-018834-4ligp4ak	224	1	In	in	IN
cord-018834-4ligp4ak	224	2	a	a	DT
cord-018834-4ligp4ak	224	3	rat	rat	NN
cord-018834-4ligp4ak	224	4	model	model	NN
cord-018834-4ligp4ak	224	5	of	of	IN
cord-018834-4ligp4ak	224	6	acute	acute	JJ
cord-018834-4ligp4ak	224	7	ischemic	ischemic	JJ
cord-018834-4ligp4ak	224	8	stroke	stroke	NN
cord-018834-4ligp4ak	224	9	induced	induce	VBN
cord-018834-4ligp4ak	224	10	by	by	IN
cord-018834-4ligp4ak	224	11	MCAO	MCAO	NNP
cord-018834-4ligp4ak	224	12	,	,	,
cord-018834-4ligp4ak	224	13	rats	rat	NNS
cord-018834-4ligp4ak	224	14	received	receive	VBD
cord-018834-4ligp4ak	224	15	1.25	1.25	CD
cord-018834-4ligp4ak	224	16	g	g	NN
cord-018834-4ligp4ak	224	17	/	/	SYM
cord-018834-4ligp4ak	224	18	kg	kg	CC
cord-018834-4ligp4ak	224	19	intravenously	intravenously	RB
cord-018834-4ligp4ak	224	20	at	at	IN
cord-018834-4ligp4ak	224	21	2	2	CD
cord-018834-4ligp4ak	224	22	,	,	,
cord-018834-4ligp4ak	224	23	3	3	CD
cord-018834-4ligp4ak	224	24	,	,	,
cord-018834-4ligp4ak	224	25	4	4	CD
cord-018834-4ligp4ak	224	26	,	,	,
cord-018834-4ligp4ak	224	27	or	or	CC
cord-018834-4ligp4ak	224	28	5	5	CD
cord-018834-4ligp4ak	224	29	h	h	NN
cord-018834-4ligp4ak	224	30	after	after	IN
cord-018834-4ligp4ak	224	31	onset	onset	NN
cord-018834-4ligp4ak	224	32	of	of	IN
cord-018834-4ligp4ak	224	33	MCAO	MCAO	NNP
cord-018834-4ligp4ak	224	34	.	.	.
cord-018834-4ligp4ak	225	1	Albumin	albumin	NN
cord-018834-4ligp4ak	225	2	therapy	therapy	NN
cord-018834-4ligp4ak	225	3	markedly	markedly	RB
cord-018834-4ligp4ak	225	4	improved	improve	VBD
cord-018834-4ligp4ak	225	5	neurological	neurological	JJ
cord-018834-4ligp4ak	225	6	function	function	NN
cord-018834-4ligp4ak	225	7	,	,	,
cord-018834-4ligp4ak	225	8	and	and	CC
cord-018834-4ligp4ak	225	9	reduced	reduced	JJ
cord-018834-4ligp4ak	225	10	infarction	infarction	NN
cord-018834-4ligp4ak	225	11	volume	volume	NN
cord-018834-4ligp4ak	225	12	and	and	CC
cord-018834-4ligp4ak	225	13	brain	brain	NN
cord-018834-4ligp4ak	225	14	swelling	swell	VBG
cord-018834-4ligp4ak	225	15	[	[	-LRB-
cord-018834-4ligp4ak	225	16	51	51	CD
cord-018834-4ligp4ak	225	17	]	]	-RRB-
cord-018834-4ligp4ak	225	18	.	.	.
cord-018834-4ligp4ak	226	1	The	the	DT
cord-018834-4ligp4ak	226	2	neuroprotective	neuroprotective	JJ
cord-018834-4ligp4ak	226	3	effects	effect	NNS
cord-018834-4ligp4ak	226	4	of	of	IN
cord-018834-4ligp4ak	226	5	albumin	albumin	NN
cord-018834-4ligp4ak	226	6	have	have	VBP
cord-018834-4ligp4ak	226	7	been	be	VBN
cord-018834-4ligp4ak	226	8	confi	confi	VBN
cord-018834-4ligp4ak	226	9	rmed	rme	VBN
cord-018834-4ligp4ak	226	10	in	in	IN
cord-018834-4ligp4ak	226	11	a	a	DT
cord-018834-4ligp4ak	226	12	study	study	NN
cord-018834-4ligp4ak	226	13	with	with	IN
cord-018834-4ligp4ak	226	14	permanent	permanent	JJ
cord-018834-4ligp4ak	226	15	MCAO	MCAO	NNS
cord-018834-4ligp4ak	226	16	in	in	IN
cord-018834-4ligp4ak	226	17	rats	rat	NNS
cord-018834-4ligp4ak	226	18	,	,	,
cord-018834-4ligp4ak	226	19	where	where	WRB
cord-018834-4ligp4ak	226	20	albumin	albumin	NN
cord-018834-4ligp4ak	226	21	treatment	treatment	NN
cord-018834-4ligp4ak	226	22	led	lead	VBD
cord-018834-4ligp4ak	226	23	to	to	IN
cord-018834-4ligp4ak	226	24	48	48	CD
cord-018834-4ligp4ak	226	25	%	%	NN
cord-018834-4ligp4ak	226	26	increases	increase	NNS
cord-018834-4ligp4ak	226	27	in	in	IN
cord-018834-4ligp4ak	226	28	cortical	cortical	JJ
cord-018834-4ligp4ak	226	29	perfusion	perfusion	NN
cord-018834-4ligp4ak	226	30	(	(	-LRB-
cord-018834-4ligp4ak	226	31	P	p	NN
cord-018834-4ligp4ak	226	32	<	<	XX
cord-018834-4ligp4ak	226	33	0.002	0.002	CD
cord-018834-4ligp4ak	226	34	)	)	-RRB-
cord-018834-4ligp4ak	226	35	,	,	,
cord-018834-4ligp4ak	226	36	but	but	CC
cord-018834-4ligp4ak	226	37	saline	saline	NN
cord-018834-4ligp4ak	226	38	in	in	IN
cord-018834-4ligp4ak	226	39	the	the	DT
cord-018834-4ligp4ak	226	40	control	control	NN
cord-018834-4ligp4ak	226	41	group	group	NN
cord-018834-4ligp4ak	226	42	caused	cause	VBD
cord-018834-4ligp4ak	226	43	no	no	DT
cord-018834-4ligp4ak	226	44	change	change	NN
cord-018834-4ligp4ak	226	45	[	[	-LRB-
cord-018834-4ligp4ak	226	46	51	51	CD
cord-018834-4ligp4ak	226	47	]	]	-RRB-
cord-018834-4ligp4ak	226	48	.	.	.
cord-018834-4ligp4ak	227	1	Moreover	moreover	RB
cord-018834-4ligp4ak	227	2	,	,	,
cord-018834-4ligp4ak	227	3	functional	functional	JJ
cord-018834-4ligp4ak	227	4	magnetic	magnetic	JJ
cord-018834-4ligp4ak	227	5	resonance	resonance	NN
cord-018834-4ligp4ak	227	6	imaging	imaging	NN
cord-018834-4ligp4ak	227	7	(	(	-LRB-
cord-018834-4ligp4ak	227	8	fMRI	fMRI	NNP
cord-018834-4ligp4ak	227	9	)	)	-RRB-
cord-018834-4ligp4ak	227	10	was	be	VBD
cord-018834-4ligp4ak	227	11	used	use	VBN
cord-018834-4ligp4ak	227	12	to	to	TO
cord-018834-4ligp4ak	227	13	assess	assess	VB
cord-018834-4ligp4ak	227	14	the	the	DT
cord-018834-4ligp4ak	227	15	albumin	albumin	NN
cord-018834-4ligp4ak	227	16	treatment	treatment	NN
cord-018834-4ligp4ak	227	17	during	during	IN
cord-018834-4ligp4ak	227	18	stroke	stroke	NN
cord-018834-4ligp4ak	227	19	recovery	recovery	NN
cord-018834-4ligp4ak	227	20	in	in	IN
cord-018834-4ligp4ak	227	21	rats	rat	NNS
cord-018834-4ligp4ak	227	22	.	.	.
cord-018834-4ligp4ak	228	1	Albumin	albumin	NN
cord-018834-4ligp4ak	228	2	treatment	treatment	NN
cord-018834-4ligp4ak	228	3	was	be	VBD
cord-018834-4ligp4ak	228	4	associated	associate	VBN
cord-018834-4ligp4ak	228	5	with	with	IN
cord-018834-4ligp4ak	228	6	restoration	restoration	NN
cord-018834-4ligp4ak	228	7	of	of	IN
cord-018834-4ligp4ak	228	8	fMRI	fmri	NN
cord-018834-4ligp4ak	228	9	response	response	NN
cord-018834-4ligp4ak	228	10	magnitudes	magnitude	NNS
cord-018834-4ligp4ak	228	11	and	and	CC
cord-018834-4ligp4ak	228	12	temporal	temporal	JJ
cord-018834-4ligp4ak	228	13	profi	profi	FW
cord-018834-4ligp4ak	228	14	les	les	NNP
cord-018834-4ligp4ak	228	15	[	[	-LRB-
cord-018834-4ligp4ak	228	16	52	52	CD
cord-018834-4ligp4ak	228	17	]	]	-RRB-
cord-018834-4ligp4ak	228	18	.	.	.
cord-018834-4ligp4ak	229	1	Rats	rat	NNS
cord-018834-4ligp4ak	229	2	underwent	undergo	VBD
cord-018834-4ligp4ak	229	3	subarachnoid	subarachnoid	JJ
cord-018834-4ligp4ak	229	4	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	229	5	by	by	IN
cord-018834-4ligp4ak	229	6	endovascular	endovascular	JJ
cord-018834-4ligp4ak	229	7	perforation	perforation	NN
cord-018834-4ligp4ak	229	8	.	.	.
cord-018834-4ligp4ak	230	1	Albumin	albumin	NN
cord-018834-4ligp4ak	230	2	of	of	IN
cord-018834-4ligp4ak	230	3	either	either	DT
cord-018834-4ligp4ak	230	4	0.63	0.63	CD
cord-018834-4ligp4ak	230	5	or	or	CC
cord-018834-4ligp4ak	230	6	1.25	1.25	CD
cord-018834-4ligp4ak	230	7	g	g	NN
cord-018834-4ligp4ak	230	8	/	/	SYM
cord-018834-4ligp4ak	230	9	kg	kg	NNP
cord-018834-4ligp4ak	230	10	was	be	VBD
cord-018834-4ligp4ak	230	11	injected	inject	VBN
cord-018834-4ligp4ak	230	12	immediately	immediately	RB
cord-018834-4ligp4ak	230	13	after	after	IN
cord-018834-4ligp4ak	230	14	the	the	DT
cord-018834-4ligp4ak	230	15	surgery	surgery	NN
cord-018834-4ligp4ak	230	16	.	.	.
cord-018834-4ligp4ak	231	1	Albumin	albumin	NN
cord-018834-4ligp4ak	231	2	at	at	IN
cord-018834-4ligp4ak	231	3	lowto	lowto	NN
cord-018834-4ligp4ak	231	4	-	-	HYPH
cord-018834-4ligp4ak	231	5	moderate	moderate	JJ
cord-018834-4ligp4ak	231	6	doses	dose	NNS
cord-018834-4ligp4ak	231	7	markedly	markedly	RB
cord-018834-4ligp4ak	231	8	improves	improve	VBZ
cord-018834-4ligp4ak	231	9	long	long	JJ
cord-018834-4ligp4ak	231	10	-	-	HYPH
cord-018834-4ligp4ak	231	11	term	term	NN
cord-018834-4ligp4ak	231	12	neurobehavioral	neurobehavioral	JJ
cord-018834-4ligp4ak	231	13	sequelae	sequela	NNS
cord-018834-4ligp4ak	231	14	after	after	IN
cord-018834-4ligp4ak	231	15	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	231	16	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	231	17	[	[	-LRB-
cord-018834-4ligp4ak	231	18	53	53	CD
cord-018834-4ligp4ak	231	19	]	]	-RRB-
cord-018834-4ligp4ak	231	20	.	.	.
cord-018834-4ligp4ak	232	1	There	there	EX
cord-018834-4ligp4ak	232	2	are	be	VBP
cord-018834-4ligp4ak	232	3	only	only	RB
cord-018834-4ligp4ak	232	4	two	two	CD
cord-018834-4ligp4ak	232	5	large	large	JJ
cord-018834-4ligp4ak	232	6	published	publish	VBN
cord-018834-4ligp4ak	232	7	trials	trial	NNS
cord-018834-4ligp4ak	232	8	for	for	IN
cord-018834-4ligp4ak	232	9	the	the	DT
cord-018834-4ligp4ak	232	10	use	use	NN
cord-018834-4ligp4ak	232	11	of	of	IN
cord-018834-4ligp4ak	232	12	albumin	albumin	NN
cord-018834-4ligp4ak	232	13	after	after	IN
cord-018834-4ligp4ak	232	14	acute	acute	JJ
cord-018834-4ligp4ak	232	15	ischemic	ischemic	JJ
cord-018834-4ligp4ak	232	16	stroke	stroke	NN
cord-018834-4ligp4ak	232	17	and	and	CC
cord-018834-4ligp4ak	232	18	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	232	19	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	232	20	(	(	-LRB-
cord-018834-4ligp4ak	232	21	SAH	SAH	NNP
cord-018834-4ligp4ak	232	22	)	)	-RRB-
cord-018834-4ligp4ak	232	23	.	.	.
cord-018834-4ligp4ak	233	1	In	in	IN
cord-018834-4ligp4ak	233	2	a	a	DT
cord-018834-4ligp4ak	233	3	randomized	randomized	JJ
cord-018834-4ligp4ak	233	4	,	,	,
cord-018834-4ligp4ak	233	5	double	double	JJ
cord-018834-4ligp4ak	233	6	-	-	HYPH
cord-018834-4ligp4ak	233	7	blind	blind	JJ
cord-018834-4ligp4ak	233	8	,	,	,
cord-018834-4ligp4ak	233	9	parallel	parallel	JJ
cord-018834-4ligp4ak	233	10	-	-	HYPH
cord-018834-4ligp4ak	233	11	group	group	NN
cord-018834-4ligp4ak	233	12	multicenter	multicenter	JJ
cord-018834-4ligp4ak	233	13	trial	trial	NN
cord-018834-4ligp4ak	233	14	in	in	IN
cord-018834-4ligp4ak	233	15	patients	patient	NNS
cord-018834-4ligp4ak	233	16	with	with	IN
cord-018834-4ligp4ak	233	17	acute	acute	JJ
cord-018834-4ligp4ak	233	18	ischemic	ischemic	JJ
cord-018834-4ligp4ak	233	19	stroke	stroke	NN
cord-018834-4ligp4ak	233	20	with	with	IN
cord-018834-4ligp4ak	233	21	a	a	DT
cord-018834-4ligp4ak	233	22	baseline	baseline	JJ
cord-018834-4ligp4ak	233	23	National	National	NNP
cord-018834-4ligp4ak	233	24	Institutes	Institutes	NNPS
cord-018834-4ligp4ak	233	25	of	of	IN
cord-018834-4ligp4ak	233	26	Health	Health	NNP
cord-018834-4ligp4ak	233	27	Stroke	Stroke	NNP
cord-018834-4ligp4ak	233	28	Scale	Scale	NNP
cord-018834-4ligp4ak	233	29	(	(	-LRB-
cord-018834-4ligp4ak	233	30	NIHSS	NIHSS	NNP
cord-018834-4ligp4ak	233	31	)	)	-RRB-
cord-018834-4ligp4ak	233	32	,	,	,
cord-018834-4ligp4ak	233	33	422	422	CD
cord-018834-4ligp4ak	233	34	patients	patient	NNS
cord-018834-4ligp4ak	233	35	were	be	VBD
cord-018834-4ligp4ak	233	36	randomly	randomly	RB
cord-018834-4ligp4ak	233	37	assigned	assign	VBN
cord-018834-4ligp4ak	233	38	to	to	TO
cord-018834-4ligp4ak	233	39	receive	receive	VB
cord-018834-4ligp4ak	233	40	25	25	CD
cord-018834-4ligp4ak	233	41	%	%	NN
cord-018834-4ligp4ak	233	42	albumin	albumin	NN
cord-018834-4ligp4ak	233	43	(	(	-LRB-
cord-018834-4ligp4ak	233	44	2	2	CD
cord-018834-4ligp4ak	233	45	g	g	NN
cord-018834-4ligp4ak	233	46	[	[	-LRB-
cord-018834-4ligp4ak	233	47	8	8	CD
cord-018834-4ligp4ak	233	48	ml	ml	NN
cord-018834-4ligp4ak	233	49	]	]	-RRB-
cord-018834-4ligp4ak	233	50	per	per	IN
cord-018834-4ligp4ak	233	51	kg	kg	NN
cord-018834-4ligp4ak	233	52	;	;	:
cord-018834-4ligp4ak	233	53	maximum	maximum	VB
cord-018834-4ligp4ak	233	54	750	750	CD
cord-018834-4ligp4ak	233	55	ml	ml	NN
cord-018834-4ligp4ak	233	56	)	)	-RRB-
cord-018834-4ligp4ak	233	57	and	and	CC
cord-018834-4ligp4ak	233	58	419	419	CD
cord-018834-4ligp4ak	233	59	to	to	TO
cord-018834-4ligp4ak	233	60	receive	receive	VB
cord-018834-4ligp4ak	233	61	an	an	DT
cord-018834-4ligp4ak	233	62	equivalent	equivalent	JJ
cord-018834-4ligp4ak	233	63	volume	volume	NN
cord-018834-4ligp4ak	233	64	of	of	IN
cord-018834-4ligp4ak	233	65	isotonic	isotonic	JJ
cord-018834-4ligp4ak	233	66	saline	saline	NN
cord-018834-4ligp4ak	233	67	.	.	.
cord-018834-4ligp4ak	234	1	The	the	DT
cord-018834-4ligp4ak	234	2	primary	primary	JJ
cord-018834-4ligp4ak	234	3	outcome	outcome	NN
cord-018834-4ligp4ak	234	4	was	be	VBD
cord-018834-4ligp4ak	234	5	favorable	favorable	JJ
cord-018834-4ligp4ak	234	6	,	,	,
cord-018834-4ligp4ak	234	7	defi	defi	NNP
cord-018834-4ligp4ak	234	8	ned	ned	NNP
cord-018834-4ligp4ak	234	9	as	as	IN
cord-018834-4ligp4ak	234	10	either	either	CC
cord-018834-4ligp4ak	234	11	a	a	DT
cord-018834-4ligp4ak	234	12	modifi	modifi	NN
cord-018834-4ligp4ak	234	13	ed	ed	NNP
cord-018834-4ligp4ak	234	14	Rankin	Rankin	NNP
cord-018834-4ligp4ak	234	15	scale	scale	NN
cord-018834-4ligp4ak	234	16	score	score	NN
cord-018834-4ligp4ak	234	17	of	of	IN
cord-018834-4ligp4ak	234	18	0	0	CD
cord-018834-4ligp4ak	234	19	or	or	CC
cord-018834-4ligp4ak	234	20	1	1	CD
cord-018834-4ligp4ak	234	21	,	,	,
cord-018834-4ligp4ak	234	22	or	or	CC
cord-018834-4ligp4ak	234	23	an	an	DT
cord-018834-4ligp4ak	234	24	NIHSS	NIHSS	NNP
cord-018834-4ligp4ak	234	25	score	score	NN
cord-018834-4ligp4ak	234	26	of	of	IN
cord-018834-4ligp4ak	234	27	0	0	CD
cord-018834-4ligp4ak	234	28	or	or	CC
cord-018834-4ligp4ak	234	29	1	1	CD
cord-018834-4ligp4ak	234	30	,	,	,
cord-018834-4ligp4ak	234	31	or	or	CC
cord-018834-4ligp4ak	234	32	both	both	DT
cord-018834-4ligp4ak	234	33	,	,	,
cord-018834-4ligp4ak	234	34	at	at	IN
cord-018834-4ligp4ak	234	35	90	90	CD
cord-018834-4ligp4ak	234	36	days	day	NNS
cord-018834-4ligp4ak	234	37	.	.	.
cord-018834-4ligp4ak	235	1	The	the	DT
cord-018834-4ligp4ak	235	2	rate	rate	NN
cord-018834-4ligp4ak	235	3	of	of	IN
cord-018834-4ligp4ak	235	4	favorable	favorable	JJ
cord-018834-4ligp4ak	235	5	outcome	outcome	NN
cord-018834-4ligp4ak	235	6	did	do	VBD
cord-018834-4ligp4ak	235	7	not	not	RB
cord-018834-4ligp4ak	235	8	differ	differ	VB
cord-018834-4ligp4ak	235	9	between	between	IN
cord-018834-4ligp4ak	235	10	the	the	DT
cord-018834-4ligp4ak	235	11	groups	group	NNS
cord-018834-4ligp4ak	235	12	.	.	.
cord-018834-4ligp4ak	236	1	However	however	RB
cord-018834-4ligp4ak	236	2	,	,	,
cord-018834-4ligp4ak	236	3	the	the	DT
cord-018834-4ligp4ak	236	4	patients	patient	NNS
cord-018834-4ligp4ak	236	5	in	in	IN
cord-018834-4ligp4ak	236	6	the	the	DT
cord-018834-4ligp4ak	236	7	albumin	albumin	NN
cord-018834-4ligp4ak	236	8	group	group	NN
cord-018834-4ligp4ak	236	9	had	have	VBD
cord-018834-4ligp4ak	236	10	more	more	RBR
cord-018834-4ligp4ak	236	11	mild	mild	JJ
cord-018834-4ligp4ak	236	12	-	-	HYPH
cord-018834-4ligp4ak	236	13	to	to	IN
cord-018834-4ligp4ak	236	14	-	-	HYPH
cord-018834-4ligp4ak	236	15	moderate	moderate	JJ
cord-018834-4ligp4ak	236	16	pulmonary	pulmonary	JJ
cord-018834-4ligp4ak	236	17	edema	edema	NN
cord-018834-4ligp4ak	236	18	and	and	CC
cord-018834-4ligp4ak	236	19	symptomatic	symptomatic	JJ
cord-018834-4ligp4ak	236	20	intracranial	intracranial	JJ
cord-018834-4ligp4ak	236	21	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	236	22	[	[	-LRB-
cord-018834-4ligp4ak	236	23	54	54	CD
cord-018834-4ligp4ak	236	24	]	]	-RRB-
cord-018834-4ligp4ak	236	25	.	.	.
cord-018834-4ligp4ak	237	1	The	the	DT
cord-018834-4ligp4ak	237	2	reason	reason	NN
cord-018834-4ligp4ak	237	3	for	for	IN
cord-018834-4ligp4ak	237	4	the	the	DT
cord-018834-4ligp4ak	237	5	negative	negative	JJ
cord-018834-4ligp4ak	237	6	outcome	outcome	NN
cord-018834-4ligp4ak	237	7	of	of	IN
cord-018834-4ligp4ak	237	8	this	this	DT
cord-018834-4ligp4ak	237	9	well	well	RB
cord-018834-4ligp4ak	237	10	-	-	HYPH
cord-018834-4ligp4ak	237	11	designed	design	VBN
cord-018834-4ligp4ak	237	12	study	study	NN
cord-018834-4ligp4ak	237	13	was	be	VBD
cord-018834-4ligp4ak	237	14	the	the	DT
cord-018834-4ligp4ak	237	15	high	high	JJ
cord-018834-4ligp4ak	237	16	dose	dose	NN
cord-018834-4ligp4ak	237	17	of	of	IN
cord-018834-4ligp4ak	237	18	albumin	albumin	NN
cord-018834-4ligp4ak	237	19	given	give	VBN
cord-018834-4ligp4ak	237	20	as	as	IN
cord-018834-4ligp4ak	237	21	a	a	DT
cord-018834-4ligp4ak	237	22	single	single	JJ
cord-018834-4ligp4ak	237	23	bolus	bolus	NN
cord-018834-4ligp4ak	237	24	,	,	,
cord-018834-4ligp4ak	237	25	which	which	WDT
cord-018834-4ligp4ak	237	26	might	may	MD
cord-018834-4ligp4ak	237	27	have	have	VB
cord-018834-4ligp4ak	237	28	induced	induce	VBN
cord-018834-4ligp4ak	237	29	those	those	DT
cord-018834-4ligp4ak	237	30	unfavorable	unfavorable	JJ
cord-018834-4ligp4ak	237	31	effects	effect	NNS
cord-018834-4ligp4ak	237	32	and	and	CC
cord-018834-4ligp4ak	237	33	obscured	obscure	VBD
cord-018834-4ligp4ak	237	34	the	the	DT
cord-018834-4ligp4ak	237	35	neuroprotective	neuroprotective	JJ
cord-018834-4ligp4ak	237	36	effect	effect	NN
cord-018834-4ligp4ak	237	37	of	of	IN
cord-018834-4ligp4ak	237	38	albumin	albumin	NN
cord-018834-4ligp4ak	237	39	.	.	.
cord-018834-4ligp4ak	238	1	Albumin	albumin	NN
cord-018834-4ligp4ak	238	2	in	in	IN
cord-018834-4ligp4ak	238	3	the	the	DT
cord-018834-4ligp4ak	238	4	dose	dose	NN
cord-018834-4ligp4ak	238	5	of	of	IN
cord-018834-4ligp4ak	238	6	1.25	1.25	CD
cord-018834-4ligp4ak	238	7	g	g	NN
cord-018834-4ligp4ak	238	8	/	/	SYM
cord-018834-4ligp4ak	238	9	kg	kg	NN
cord-018834-4ligp4ak	238	10	/	/	SYM
cord-018834-4ligp4ak	238	11	day/7	day/7	NN
cord-018834-4ligp4ak	238	12	days	day	NNS
cord-018834-4ligp4ak	238	13	was	be	VBD
cord-018834-4ligp4ak	238	14	tolerated	tolerate	VBN
cord-018834-4ligp4ak	238	15	by	by	IN
cord-018834-4ligp4ak	238	16	the	the	DT
cord-018834-4ligp4ak	238	17	patients	patient	NNS
cord-018834-4ligp4ak	238	18	with	with	IN
cord-018834-4ligp4ak	238	19	SAH	SAH	NNP
cord-018834-4ligp4ak	238	20	without	without	IN
cord-018834-4ligp4ak	238	21	major	major	JJ
cord-018834-4ligp4ak	238	22	complications	complication	NNS
cord-018834-4ligp4ak	238	23	and	and	CC
cord-018834-4ligp4ak	238	24	may	may	MD
cord-018834-4ligp4ak	238	25	be	be	VB
cord-018834-4ligp4ak	238	26	neuroprotective	neuroprotective	JJ
cord-018834-4ligp4ak	238	27	.	.	.
cord-018834-4ligp4ak	239	1	Albumin	albumin	NN
cord-018834-4ligp4ak	239	2	in	in	IN
cord-018834-4ligp4ak	239	3	the	the	DT
cord-018834-4ligp4ak	239	4	dose	dose	NN
cord-018834-4ligp4ak	239	5	of	of	IN
cord-018834-4ligp4ak	239	6	1.25	1.25	CD
cord-018834-4ligp4ak	239	7	g	g	NN
cord-018834-4ligp4ak	239	8	/	/	SYM
cord-018834-4ligp4ak	239	9	kg	kg	NN
cord-018834-4ligp4ak	239	10	/	/	SYM
cord-018834-4ligp4ak	239	11	day/7	day/7	NN
cord-018834-4ligp4ak	239	12	days	day	NNS
cord-018834-4ligp4ak	239	13	had	have	VBD
cord-018834-4ligp4ak	239	14	lower	low	JJR
cord-018834-4ligp4ak	239	15	rates	rate	NNS
cord-018834-4ligp4ak	239	16	of	of	IN
cord-018834-4ligp4ak	239	17	cerebral	cerebral	JJ
cord-018834-4ligp4ak	239	18	vasospasm	vasospasm	NN
cord-018834-4ligp4ak	239	19	measured	measure	VBN
cord-018834-4ligp4ak	239	20	by	by	IN
cord-018834-4ligp4ak	239	21	transcranial	transcranial	JJ
cord-018834-4ligp4ak	239	22	Doppler	Doppler	NNP
cord-018834-4ligp4ak	239	23	(	(	-LRB-
cord-018834-4ligp4ak	239	24	TCD	TCD	NNP
cord-018834-4ligp4ak	239	25	)	)	-RRB-
cord-018834-4ligp4ak	239	26	,	,	,
cord-018834-4ligp4ak	239	27	delayed	delay	VBN
cord-018834-4ligp4ak	239	28	cerebral	cerebral	JJ
cord-018834-4ligp4ak	239	29	ischemia	ischemia	NN
cord-018834-4ligp4ak	239	30	(	(	-LRB-
cord-018834-4ligp4ak	239	31	DCI	DCI	NNP
cord-018834-4ligp4ak	239	32	)	)	-RRB-
cord-018834-4ligp4ak	239	33	,	,	,
cord-018834-4ligp4ak	239	34	and	and	CC
cord-018834-4ligp4ak	239	35	cerebral	cerebral	JJ
cord-018834-4ligp4ak	239	36	infarctions	infarction	NNS
cord-018834-4ligp4ak	239	37	.	.	.
cord-018834-4ligp4ak	240	1	The	the	DT
cord-018834-4ligp4ak	240	2	main	main	JJ
cord-018834-4ligp4ak	240	3	physiological	physiological	JJ
cord-018834-4ligp4ak	240	4	effects	effect	NNS
cord-018834-4ligp4ak	240	5	of	of	IN
cord-018834-4ligp4ak	240	6	albumin	albumin	NN
cord-018834-4ligp4ak	240	7	treatment	treatment	NN
cord-018834-4ligp4ak	240	8	were	be	VBD
cord-018834-4ligp4ak	240	9	elevation	elevation	NN
cord-018834-4ligp4ak	240	10	of	of	IN
cord-018834-4ligp4ak	240	11	the	the	DT
cord-018834-4ligp4ak	240	12	serum	serum	NN
cord-018834-4ligp4ak	240	13	albumin	albumin	NN
cord-018834-4ligp4ak	240	14	concentration	concentration	NN
cord-018834-4ligp4ak	240	15	and	and	CC
cord-018834-4ligp4ak	240	16	mean	mean	VB
cord-018834-4ligp4ak	240	17	arterial	arterial	JJ
cord-018834-4ligp4ak	240	18	blood	blood	NN
cord-018834-4ligp4ak	240	19	pressure	pressure	NN
cord-018834-4ligp4ak	240	20	.	.	.
cord-018834-4ligp4ak	241	1	In	in	IN
cord-018834-4ligp4ak	241	2	addition	addition	NN
cord-018834-4ligp4ak	241	3	,	,	,
cord-018834-4ligp4ak	241	4	serum	serum	NN
cord-018834-4ligp4ak	241	5	albumin	albumin	NN
cord-018834-4ligp4ak	241	6	remained	remain	VBD
cord-018834-4ligp4ak	241	7	elevated	elevated	JJ
cord-018834-4ligp4ak	241	8	7	7	CD
cord-018834-4ligp4ak	241	9	days	day	NNS
cord-018834-4ligp4ak	241	10	after	after	IN
cord-018834-4ligp4ak	241	11	treatment	treatment	NN
cord-018834-4ligp4ak	241	12	,	,	,
cord-018834-4ligp4ak	241	13	which	which	WDT
cord-018834-4ligp4ak	241	14	might	may	MD
cord-018834-4ligp4ak	241	15	be	be	VB
cord-018834-4ligp4ak	241	16	benefi	benefi	NNP
cord-018834-4ligp4ak	241	17	cial	cial	NN
cord-018834-4ligp4ak	241	18	throughout	throughout	IN
cord-018834-4ligp4ak	241	19	the	the	DT
cord-018834-4ligp4ak	241	20	critical	critical	JJ
cord-018834-4ligp4ak	241	21	period	period	NN
cord-018834-4ligp4ak	241	22	of	of	IN
cord-018834-4ligp4ak	241	23	DCI	DCI	NNP
cord-018834-4ligp4ak	241	24	[	[	-LRB-
cord-018834-4ligp4ak	241	25	55	55	CD
cord-018834-4ligp4ak	241	26	,	,	,
cord-018834-4ligp4ak	241	27	56	56	CD
cord-018834-4ligp4ak	241	28	]	]	-RRB-
cord-018834-4ligp4ak	241	29	.	.	.
cord-018834-4ligp4ak	242	1	The	the	DT
cord-018834-4ligp4ak	242	2	mechanisms	mechanism	NNS
cord-018834-4ligp4ak	242	3	of	of	IN
cord-018834-4ligp4ak	242	4	the	the	DT
cord-018834-4ligp4ak	242	5	neuroprotective	neuroprotective	JJ
cord-018834-4ligp4ak	242	6	effects	effect	NNS
cord-018834-4ligp4ak	242	7	of	of	IN
cord-018834-4ligp4ak	242	8	albumin	albumin	NN
cord-018834-4ligp4ak	242	9	could	could	MD
cord-018834-4ligp4ak	242	10	be	be	VB
cord-018834-4ligp4ak	242	11	explained	explain	VBN
cord-018834-4ligp4ak	242	12	by	by	IN
cord-018834-4ligp4ak	242	13	its	-PRON-	PRP$
cord-018834-4ligp4ak	242	14	ability	ability	NN
cord-018834-4ligp4ak	242	15	to	to	TO
cord-018834-4ligp4ak	242	16	attenuate	attenuate	VB
cord-018834-4ligp4ak	242	17	brain	brain	NN
cord-018834-4ligp4ak	242	18	edema	edema	NN
cord-018834-4ligp4ak	242	19	and	and	CC
cord-018834-4ligp4ak	242	20	inhibit	inhibit	VB
cord-018834-4ligp4ak	242	21	the	the	DT
cord-018834-4ligp4ak	242	22	endothelia	endothelia	NNP
cord-018834-4ligp4ak	242	23	cell	cell	NN
cord-018834-4ligp4ak	242	24	apoptosis	apoptosis	NN
cord-018834-4ligp4ak	242	25	[	[	-LRB-
cord-018834-4ligp4ak	242	26	57	57	CD
cord-018834-4ligp4ak	242	27	,	,	,
cord-018834-4ligp4ak	242	28	58	58	CD
cord-018834-4ligp4ak	242	29	]	]	-RRB-
cord-018834-4ligp4ak	242	30	.	.	.
cord-018834-4ligp4ak	243	1	Albumin	albumin	NN
cord-018834-4ligp4ak	243	2	administration	administration	NN
cord-018834-4ligp4ak	243	3	may	may	MD
cord-018834-4ligp4ak	243	4	improve	improve	VB
cord-018834-4ligp4ak	243	5	microcirculatory	microcirculatory	NNP
cord-018834-4ligp4ak	243	6	blood	blood	NN
cord-018834-4ligp4ak	243	7	fl	fl	NNP
cord-018834-4ligp4ak	243	8	ow	ow	UH
cord-018834-4ligp4ak	243	9	,	,	,
cord-018834-4ligp4ak	243	10	increase	increase	VB
cord-018834-4ligp4ak	243	11	organ	organ	NN
cord-018834-4ligp4ak	243	12	perfusion	perfusion	NN
cord-018834-4ligp4ak	243	13	,	,	,
cord-018834-4ligp4ak	243	14	decrease	decrease	VB
cord-018834-4ligp4ak	243	15	leukocyte	leukocyte	NN
cord-018834-4ligp4ak	243	16	rolling	rolling	NN
cord-018834-4ligp4ak	243	17	and	and	CC
cord-018834-4ligp4ak	243	18	adherence	adherence	NN
cord-018834-4ligp4ak	243	19	,	,	,
cord-018834-4ligp4ak	243	20	and	and	CC
cord-018834-4ligp4ak	243	21	reduce	reduce	VB
cord-018834-4ligp4ak	243	22	the	the	DT
cord-018834-4ligp4ak	243	23	infl	infl	NNP
cord-018834-4ligp4ak	243	24	ammatory	ammatory	NNP
cord-018834-4ligp4ak	243	25	response	response	NN
cord-018834-4ligp4ak	243	26	[	[	-LRB-
cord-018834-4ligp4ak	243	27	59	59	CD
cord-018834-4ligp4ak	243	28	]	]	-RRB-
cord-018834-4ligp4ak	243	29	.	.	.
cord-018834-4ligp4ak	244	1	Albumin	albumin	NN
cord-018834-4ligp4ak	244	2	preserves	preserve	VBZ
cord-018834-4ligp4ak	244	3	the	the	DT
cord-018834-4ligp4ak	244	4	blood	blood	NN
cord-018834-4ligp4ak	244	5	brain	brain	NN
cord-018834-4ligp4ak	244	6	barrier	barrier	NN
cord-018834-4ligp4ak	244	7	(	(	-LRB-
cord-018834-4ligp4ak	244	8	BBB	BBB	NNP
cord-018834-4ligp4ak	244	9	)	)	-RRB-
cord-018834-4ligp4ak	244	10	by	by	IN
cord-018834-4ligp4ak	244	11	abolishing	abolish	VBG
cord-018834-4ligp4ak	244	12	the	the	DT
cord-018834-4ligp4ak	244	13	hyperactivation	hyperactivation	NN
cord-018834-4ligp4ak	244	14	of	of	IN
cord-018834-4ligp4ak	244	15	metalloproteinases	metalloproteinase	NNS
cord-018834-4ligp4ak	244	16	−2	−2	NNP
cord-018834-4ligp4ak	244	17	and	and	CC
cord-018834-4ligp4ak	245	1	−9	−9	NNP
cord-018834-4ligp4ak	245	2	(	(	-LRB-
cord-018834-4ligp4ak	245	3	MMP-2/9	MMP-2/9	NNP
cord-018834-4ligp4ak	245	4	)	)	-RRB-
cord-018834-4ligp4ak	245	5	following	follow	VBG
cord-018834-4ligp4ak	245	6	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	245	7	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	245	8	,	,	,
cord-018834-4ligp4ak	245	9	suggesting	suggest	VBG
cord-018834-4ligp4ak	245	10	MMP-2	MMP-2	NNP
cord-018834-4ligp4ak	245	11	and	and	CC
cord-018834-4ligp4ak	245	12	MMP-9	MMP-9	NNP
cord-018834-4ligp4ak	245	13	are	be	VBP
cord-018834-4ligp4ak	245	14	key	key	JJ
cord-018834-4ligp4ak	245	15	mediators	mediator	NNS
cord-018834-4ligp4ak	245	16	for	for	IN
cord-018834-4ligp4ak	245	17	the	the	DT
cord-018834-4ligp4ak	245	18	albumin	albumin	NN
cord-018834-4ligp4ak	245	19	-	-	HYPH
cord-018834-4ligp4ak	245	20	induced	induce	VBN
cord-018834-4ligp4ak	245	21	neurovascular	neurovascular	JJ
cord-018834-4ligp4ak	245	22	protection	protection	NN
cord-018834-4ligp4ak	245	23	[	[	-LRB-
cord-018834-4ligp4ak	245	24	53	53	CD
cord-018834-4ligp4ak	245	25	]	]	-RRB-
cord-018834-4ligp4ak	245	26	.	.	.
cord-018834-4ligp4ak	246	1	Moreover	moreover	RB
cord-018834-4ligp4ak	246	2	,	,	,
cord-018834-4ligp4ak	246	3	albumin	albumin	NN
cord-018834-4ligp4ak	246	4	is	be	VBZ
cord-018834-4ligp4ak	246	5	considered	consider	VBN
cord-018834-4ligp4ak	246	6	the	the	DT
cord-018834-4ligp4ak	246	7	major	major	JJ
cord-018834-4ligp4ak	246	8	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	246	9	agent	agent	NN
cord-018834-4ligp4ak	246	10	in	in	IN
cord-018834-4ligp4ak	246	11	the	the	DT
cord-018834-4ligp4ak	246	12	body	body	NN
cord-018834-4ligp4ak	246	13	.	.	.
cord-018834-4ligp4ak	247	1	Albumin	albumin	NN
cord-018834-4ligp4ak	247	2	functions	function	NNS
cord-018834-4ligp4ak	247	3	as	as	IN
cord-018834-4ligp4ak	247	4	an	an	DT
cord-018834-4ligp4ak	247	5	endogenous	endogenous	JJ
cord-018834-4ligp4ak	247	6	nitric	nitric	NN
cord-018834-4ligp4ak	247	7	oxide	oxide	NN
cord-018834-4ligp4ak	247	8	(	(	-LRB-
cord-018834-4ligp4ak	247	9	NO	no	UH
cord-018834-4ligp4ak	247	10	)	)	-RRB-
cord-018834-4ligp4ak	247	11	reservoir	reservoir	NN
cord-018834-4ligp4ak	247	12	via	via	IN
cord-018834-4ligp4ak	247	13	binding	binding	NN
cord-018834-4ligp4ak	247	14	of	of	IN
cord-018834-4ligp4ak	247	15	its	-PRON-	PRP$
cord-018834-4ligp4ak	247	16	sulfhydryl	sulfhydryl	NN
cord-018834-4ligp4ak	247	17	moiety	moiety	NN
cord-018834-4ligp4ak	247	18	of	of	IN
cord-018834-4ligp4ak	247	19	cysteine	cysteine	NN
cord-018834-4ligp4ak	247	20	34	34	CD
cord-018834-4ligp4ak	247	21	residue	residue	NN
cord-018834-4ligp4ak	247	22	with	with	IN
cord-018834-4ligp4ak	247	23	NO	no	NN
cord-018834-4ligp4ak	247	24	to	to	TO
cord-018834-4ligp4ak	247	25	form	form	VB
cord-018834-4ligp4ak	247	26	S	S	NNP
cord-018834-4ligp4ak	247	27	-	-	HYPH
cord-018834-4ligp4ak	247	28	nitrosothiols	nitrosothiols	NNP
cord-018834-4ligp4ak	247	29	(	(	-LRB-
cord-018834-4ligp4ak	247	30	RSNO	RSNO	NNP
cord-018834-4ligp4ak	247	31	)	)	-RRB-
cord-018834-4ligp4ak	247	32	.	.	.
cord-018834-4ligp4ak	248	1	It	-PRON-	PRP
cord-018834-4ligp4ak	248	2	is	be	VBZ
cord-018834-4ligp4ak	248	3	worth	worth	JJ
cord-018834-4ligp4ak	248	4	mentioning	mention	VBG
cord-018834-4ligp4ak	248	5	that	that	IN
cord-018834-4ligp4ak	248	6	82	82	CD
cord-018834-4ligp4ak	248	7	%	%	NN
cord-018834-4ligp4ak	248	8	of	of	IN
cord-018834-4ligp4ak	248	9	NO	no	DT
cord-018834-4ligp4ak	248	10	in	in	IN
cord-018834-4ligp4ak	248	11	blood	blood	NN
cord-018834-4ligp4ak	248	12	is	be	VBZ
cord-018834-4ligp4ak	248	13	preserved	preserve	VBN
cord-018834-4ligp4ak	248	14	in	in	IN
cord-018834-4ligp4ak	248	15	stable	stable	JJ
cord-018834-4ligp4ak	248	16	form	form	NN
cord-018834-4ligp4ak	248	17	as	as	IN
cord-018834-4ligp4ak	248	18	RSNO	RSNO	NNP
cord-018834-4ligp4ak	248	19	[	[	-LRB-
cord-018834-4ligp4ak	248	20	13	13	CD
cord-018834-4ligp4ak	248	21	]	]	-RRB-
cord-018834-4ligp4ak	248	22	.	.	.
cord-018834-4ligp4ak	249	1	Therefore	therefore	RB
cord-018834-4ligp4ak	249	2	,	,	,
cord-018834-4ligp4ak	249	3	albumin	albumin	NN
cord-018834-4ligp4ak	249	4	is	be	VBZ
cord-018834-4ligp4ak	249	5	able	able	JJ
cord-018834-4ligp4ak	249	6	to	to	TO
cord-018834-4ligp4ak	249	7	neutralize	neutralize	VB
cord-018834-4ligp4ak	249	8	the	the	DT
cord-018834-4ligp4ak	249	9	excessive	excessive	JJ
cord-018834-4ligp4ak	249	10	circulating	circulating	NN
cord-018834-4ligp4ak	250	1	NO	no	RB
cord-018834-4ligp4ak	250	2	so	so	IN
cord-018834-4ligp4ak	250	3	as	as	IN
cord-018834-4ligp4ak	250	4	to	to	TO
cord-018834-4ligp4ak	250	5	prevent	prevent	VB
cord-018834-4ligp4ak	250	6	the	the	DT
cord-018834-4ligp4ak	250	7	nitro	nitro	NN
cord-018834-4ligp4ak	250	8	-	-	HYPH
cord-018834-4ligp4ak	250	9	oxidative	oxidative	JJ
cord-018834-4ligp4ak	250	10	stress	stress	NN
cord-018834-4ligp4ak	250	11	and	and	CC
cord-018834-4ligp4ak	250	12	,	,	,
cord-018834-4ligp4ak	250	13	on	on	IN
cord-018834-4ligp4ak	250	14	the	the	DT
cord-018834-4ligp4ak	250	15	other	other	JJ
cord-018834-4ligp4ak	250	16	hand	hand	NN
cord-018834-4ligp4ak	250	17	,	,	,
cord-018834-4ligp4ak	250	18	to	to	TO
cord-018834-4ligp4ak	250	19	continue	continue	VB
cord-018834-4ligp4ak	250	20	to	to	TO
cord-018834-4ligp4ak	250	21	release	release	VB
cord-018834-4ligp4ak	250	22	NO	no	RB
cord-018834-4ligp4ak	250	23	when	when	WRB
cord-018834-4ligp4ak	250	24	the	the	DT
cord-018834-4ligp4ak	250	25	concentrations	concentration	NNS
cord-018834-4ligp4ak	250	26	of	of	IN
cord-018834-4ligp4ak	250	27	lowmolecular	lowmolecular	JJ
cord-018834-4ligp4ak	250	28	thiols	thiol	NNS
cord-018834-4ligp4ak	250	29	are	be	VBP
cord-018834-4ligp4ak	250	30	elevated	elevated	JJ
cord-018834-4ligp4ak	250	31	.	.	.
cord-018834-4ligp4ak	251	1	Thereby	thereby	RB
cord-018834-4ligp4ak	251	2	,	,	,
cord-018834-4ligp4ak	251	3	albumin	albumin	NN
cord-018834-4ligp4ak	251	4	via	via	IN
cord-018834-4ligp4ak	251	5	RSNO	RSNO	NNP
cord-018834-4ligp4ak	251	6	-	-	HYPH
cord-018834-4ligp4ak	251	7	adducted	adduct	VBN
cord-018834-4ligp4ak	251	8	NO	no	NN
cord-018834-4ligp4ak	251	9	can	can	MD
cord-018834-4ligp4ak	251	10	relax	relax	VB
cord-018834-4ligp4ak	251	11	blood	blood	NN
cord-018834-4ligp4ak	251	12	vessels	vessel	NNS
cord-018834-4ligp4ak	251	13	,	,	,
cord-018834-4ligp4ak	251	14	inhibit	inhibit	VBP
cord-018834-4ligp4ak	251	15	platelet	platelet	NN
cord-018834-4ligp4ak	251	16	aggregation	aggregation	NN
cord-018834-4ligp4ak	251	17	,	,	,
cord-018834-4ligp4ak	251	18	and	and	CC
cord-018834-4ligp4ak	251	19	increase	increase	VB
cord-018834-4ligp4ak	251	20	aortic	aortic	JJ
cord-018834-4ligp4ak	251	21	blood	blood	NN
cord-018834-4ligp4ak	252	1	fl	fl	NNP
cord-018834-4ligp4ak	253	1	ow	ow	UH
cord-018834-4ligp4ak	253	2	[	[	-LRB-
cord-018834-4ligp4ak	253	3	53	53	CD
cord-018834-4ligp4ak	253	4	]	]	-RRB-
cord-018834-4ligp4ak	253	5	.	.	.
cord-018834-4ligp4ak	254	1	In	in	IN
cord-018834-4ligp4ak	254	2	the	the	DT
cord-018834-4ligp4ak	254	3	SAFE	safe	JJ
cord-018834-4ligp4ak	254	4	trial	trial	NN
cord-018834-4ligp4ak	254	5	,	,	,
cord-018834-4ligp4ak	254	6	patients	patient	NNS
cord-018834-4ligp4ak	254	7	with	with	IN
cord-018834-4ligp4ak	254	8	traumatic	traumatic	JJ
cord-018834-4ligp4ak	254	9	brain	brain	NN
cord-018834-4ligp4ak	254	10	injury	injury	NN
cord-018834-4ligp4ak	254	11	(	(	-LRB-
cord-018834-4ligp4ak	254	12	TBI	TBI	NNP
cord-018834-4ligp4ak	254	13	)	)	-RRB-
cord-018834-4ligp4ak	254	14	treated	treat	VBN
cord-018834-4ligp4ak	254	15	with	with	IN
cord-018834-4ligp4ak	254	16	albumin	albumin	NN
cord-018834-4ligp4ak	254	17	had	have	VBD
cord-018834-4ligp4ak	254	18	worse	bad	JJR
cord-018834-4ligp4ak	254	19	outcomes	outcome	NNS
cord-018834-4ligp4ak	254	20	than	than	IN
cord-018834-4ligp4ak	254	21	saline	saline	NN
cord-018834-4ligp4ak	254	22	,	,	,
cord-018834-4ligp4ak	254	23	most	most	RBS
cord-018834-4ligp4ak	254	24	probably	probably	RB
cord-018834-4ligp4ak	254	25	because	because	IN
cord-018834-4ligp4ak	254	26	the	the	DT
cord-018834-4ligp4ak	254	27	hypo	hypo	NN
cord-018834-4ligp4ak	254	28	-	-	HYPH
cord-018834-4ligp4ak	254	29	osmolar	osmolar	JJ
cord-018834-4ligp4ak	254	30	(	(	-LRB-
cord-018834-4ligp4ak	254	31	4	4	CD
cord-018834-4ligp4ak	254	32	%	%	NN
cord-018834-4ligp4ak	254	33	)	)	-RRB-
cord-018834-4ligp4ak	254	34	albumin	albumin	NN
cord-018834-4ligp4ak	254	35	solution	solution	NN
cord-018834-4ligp4ak	254	36	with	with	IN
cord-018834-4ligp4ak	254	37	mean	mean	JJ
cord-018834-4ligp4ak	254	38	measured	measure	VBN
cord-018834-4ligp4ak	254	39	osmolarity	osmolarity	NN
cord-018834-4ligp4ak	254	40	of	of	IN
cord-018834-4ligp4ak	254	41	266	266	CD
cord-018834-4ligp4ak	254	42	(	(	-LRB-
cord-018834-4ligp4ak	254	43	266	266	CD
cord-018834-4ligp4ak	254	44	-	-	SYM
cord-018834-4ligp4ak	254	45	267	267	CD
cord-018834-4ligp4ak	254	46	)	)	-RRB-
cord-018834-4ligp4ak	254	47	mOsm	mOsm	NNP
cord-018834-4ligp4ak	254	48	/	/	SYM
cord-018834-4ligp4ak	254	49	kg	kg	NN
cord-018834-4ligp4ak	254	50	H	h	NN
cord-018834-4ligp4ak	254	51	2	2	CD
cord-018834-4ligp4ak	254	52	O	o	NN
cord-018834-4ligp4ak	254	53	used	use	VBN
cord-018834-4ligp4ak	254	54	in	in	IN
cord-018834-4ligp4ak	254	55	the	the	DT
cord-018834-4ligp4ak	254	56	study	study	NN
cord-018834-4ligp4ak	254	57	induced	induce	VBN
cord-018834-4ligp4ak	254	58	increases	increase	NNS
cord-018834-4ligp4ak	254	59	in	in	IN
cord-018834-4ligp4ak	254	60	intracranial	intracranial	JJ
cord-018834-4ligp4ak	254	61	pressure	pressure	NN
cord-018834-4ligp4ak	254	62	but	but	CC
cord-018834-4ligp4ak	254	63	not	not	RB
cord-018834-4ligp4ak	254	64	the	the	DT
cord-018834-4ligp4ak	254	65	use	use	NN
cord-018834-4ligp4ak	254	66	of	of	IN
cord-018834-4ligp4ak	254	67	albumin	albumin	NN
cord-018834-4ligp4ak	254	68	per	per	FW
cord-018834-4ligp4ak	254	69	se	se	FW
cord-018834-4ligp4ak	254	70	[	[	-LRB-
cord-018834-4ligp4ak	254	71	60	60	CD
cord-018834-4ligp4ak	254	72	,	,	,
cord-018834-4ligp4ak	254	73	61	61	CD
cord-018834-4ligp4ak	254	74	]	]	-RRB-
cord-018834-4ligp4ak	254	75	.	.	.
cord-018834-4ligp4ak	255	1	However	however	RB
cord-018834-4ligp4ak	255	2	,	,	,
cord-018834-4ligp4ak	255	3	the	the	DT
cord-018834-4ligp4ak	255	4	use	use	NN
cord-018834-4ligp4ak	255	5	of	of	IN
cord-018834-4ligp4ak	255	6	4	4	CD
cord-018834-4ligp4ak	255	7	and	and	CC
cord-018834-4ligp4ak	255	8	20	20	CD
cord-018834-4ligp4ak	255	9	%	%	NN
cord-018834-4ligp4ak	255	10	solutions	solution	NNS
cord-018834-4ligp4ak	255	11	in	in	IN
cord-018834-4ligp4ak	255	12	93	93	CD
cord-018834-4ligp4ak	255	13	patients	patient	NNS
cord-018834-4ligp4ak	255	14	with	with	IN
cord-018834-4ligp4ak	255	15	severe	severe	JJ
cord-018834-4ligp4ak	255	16	TBI	TBI	NNP
cord-018834-4ligp4ak	255	17	and	and	CC
cord-018834-4ligp4ak	255	18	Glasgow	Glasgow	NNP
cord-018834-4ligp4ak	255	19	Coma	Coma	NNP
cord-018834-4ligp4ak	255	20	Score	Score	NNP
cord-018834-4ligp4ak	255	21	≤	≤	NNP
cord-018834-4ligp4ak	255	22	8	8	CD
cord-018834-4ligp4ak	255	23	in	in	IN
cord-018834-4ligp4ak	255	24	addition	addition	NN
cord-018834-4ligp4ak	255	25	to	to	IN
cord-018834-4ligp4ak	255	26	a	a	DT
cord-018834-4ligp4ak	255	27	neutral	neutral	JJ
cord-018834-4ligp4ak	255	28	or	or	CC
cord-018834-4ligp4ak	255	29	to	to	IN
cord-018834-4ligp4ak	255	30	a	a	DT
cord-018834-4ligp4ak	255	31	slightly	slightly	RB
cord-018834-4ligp4ak	255	32	negative	negative	JJ
cord-018834-4ligp4ak	255	33	fl	fl	NNP
cord-018834-4ligp4ak	255	34	uid	uid	NN
cord-018834-4ligp4ak	255	35	balance	balance	NN
cord-018834-4ligp4ak	255	36	was	be	VBD
cord-018834-4ligp4ak	255	37	associated	associate	VBN
cord-018834-4ligp4ak	255	38	with	with	IN
cord-018834-4ligp4ak	255	39	low	low	JJ
cord-018834-4ligp4ak	255	40	mortality	mortality	NN
cord-018834-4ligp4ak	255	41	in	in	IN
cord-018834-4ligp4ak	255	42	those	those	DT
cord-018834-4ligp4ak	255	43	patients	patient	NNS
cord-018834-4ligp4ak	255	44	[	[	-LRB-
cord-018834-4ligp4ak	255	45	62	62	CD
cord-018834-4ligp4ak	255	46	]	]	-RRB-
cord-018834-4ligp4ak	255	47	.	.	.
cord-018834-4ligp4ak	256	1	Therefore	therefore	RB
cord-018834-4ligp4ak	256	2	,	,	,
cord-018834-4ligp4ak	256	3	the	the	DT
cord-018834-4ligp4ak	256	4	correct	correct	JJ
cord-018834-4ligp4ak	256	5	conclusion	conclusion	NN
cord-018834-4ligp4ak	256	6	should	should	MD
cord-018834-4ligp4ak	256	7	be	be	VB
cord-018834-4ligp4ak	256	8	hypo	hypo	JJ
cord-018834-4ligp4ak	256	9	-	-	HYPH
cord-018834-4ligp4ak	256	10	osmolar	osmolar	JJ
cord-018834-4ligp4ak	256	11	solutions	solution	NNS
cord-018834-4ligp4ak	256	12	should	should	MD
cord-018834-4ligp4ak	256	13	not	not	RB
cord-018834-4ligp4ak	256	14	be	be	VB
cord-018834-4ligp4ak	256	15	used	use	VBN
cord-018834-4ligp4ak	256	16	in	in	IN
cord-018834-4ligp4ak	256	17	patients	patient	NNS
cord-018834-4ligp4ak	256	18	with	with	IN
cord-018834-4ligp4ak	256	19	TBI	TBI	NNP
cord-018834-4ligp4ak	256	20	[	[	-LRB-
cord-018834-4ligp4ak	256	21	63	63	CD
cord-018834-4ligp4ak	256	22	]	]	-RRB-
cord-018834-4ligp4ak	256	23	.	.	.
cord-018834-4ligp4ak	257	1	The	the	DT
cord-018834-4ligp4ak	257	2	activation	activation	NN
cord-018834-4ligp4ak	257	3	of	of	IN
cord-018834-4ligp4ak	257	4	systemic	systemic	JJ
cord-018834-4ligp4ak	257	5	infl	infl	NN
cord-018834-4ligp4ak	257	6	ammatory	ammatory	NN
cord-018834-4ligp4ak	257	7	and	and	CC
cord-018834-4ligp4ak	257	8	hemostatic	hemostatic	JJ
cord-018834-4ligp4ak	257	9	systems	system	NNS
cord-018834-4ligp4ak	257	10	that	that	WDT
cord-018834-4ligp4ak	257	11	takes	take	VBZ
cord-018834-4ligp4ak	257	12	place	place	NN
cord-018834-4ligp4ak	257	13	during	during	IN
cord-018834-4ligp4ak	257	14	cardiopulmonary	cardiopulmonary	JJ
cord-018834-4ligp4ak	257	15	bypass	bypass	NN
cord-018834-4ligp4ak	257	16	(	(	-LRB-
cord-018834-4ligp4ak	257	17	CPB	CPB	NNP
cord-018834-4ligp4ak	257	18	)	)	-RRB-
cord-018834-4ligp4ak	257	19	results	result	VBZ
cord-018834-4ligp4ak	257	20	in	in	IN
cord-018834-4ligp4ak	257	21	fi	fi	NNP
cord-018834-4ligp4ak	257	22	brin	brin	NNP
cord-018834-4ligp4ak	257	23	formation	formation	NN
cord-018834-4ligp4ak	257	24	,	,	,
cord-018834-4ligp4ak	257	25	platelet	platelet	NN
cord-018834-4ligp4ak	257	26	activation	activation	NN
cord-018834-4ligp4ak	257	27	/	/	SYM
cord-018834-4ligp4ak	257	28	consumption	consumption	NN
cord-018834-4ligp4ak	257	29	,	,	,
cord-018834-4ligp4ak	257	30	and	and	CC
cord-018834-4ligp4ak	257	31	endothelial	endothelial	JJ
cord-018834-4ligp4ak	257	32	damage	damage	NN
cord-018834-4ligp4ak	257	33	.	.	.
cord-018834-4ligp4ak	258	1	However	however	RB
cord-018834-4ligp4ak	258	2	,	,	,
cord-018834-4ligp4ak	258	3	the	the	DT
cord-018834-4ligp4ak	258	4	use	use	NN
cord-018834-4ligp4ak	258	5	of	of	IN
cord-018834-4ligp4ak	258	6	5	5	CD
cord-018834-4ligp4ak	258	7	%	%	NN
cord-018834-4ligp4ak	258	8	albumin	albumin	NN
cord-018834-4ligp4ak	258	9	in	in	IN
cord-018834-4ligp4ak	258	10	priming	prime	VBG
cord-018834-4ligp4ak	258	11	the	the	DT
cord-018834-4ligp4ak	258	12	CPB	CPB	NNP
cord-018834-4ligp4ak	258	13	machine	machine	NN
cord-018834-4ligp4ak	258	14	has	have	VBZ
cord-018834-4ligp4ak	258	15	many	many	JJ
cord-018834-4ligp4ak	258	16	advantages	advantage	NNS
cord-018834-4ligp4ak	258	17	,	,	,
cord-018834-4ligp4ak	258	18	such	such	JJ
cord-018834-4ligp4ak	258	19	as	as	IN
cord-018834-4ligp4ak	258	20	preservation	preservation	NN
cord-018834-4ligp4ak	258	21	of	of	IN
cord-018834-4ligp4ak	258	22	oncotic	oncotic	JJ
cord-018834-4ligp4ak	258	23	pressure	pressure	NN
cord-018834-4ligp4ak	258	24	,	,	,
cord-018834-4ligp4ak	258	25	preventing	prevent	VBG
cord-018834-4ligp4ak	258	26	fi	fi	NNP
cord-018834-4ligp4ak	258	27	brinogen	brinogen	NNP
cord-018834-4ligp4ak	258	28	and	and	CC
cord-018834-4ligp4ak	258	29	platelet	platelet	NN
cord-018834-4ligp4ak	258	30	adhesion	adhesion	NN
cord-018834-4ligp4ak	258	31	,	,	,
cord-018834-4ligp4ak	258	32	and	and	CC
cord-018834-4ligp4ak	258	33	endothelial	endothelial	JJ
cord-018834-4ligp4ak	258	34	glycocalyx	glycocalyx	NNP
cord-018834-4ligp4ak	258	35	protection	protection	NN
cord-018834-4ligp4ak	258	36	.	.	.
cord-018834-4ligp4ak	259	1	In	in	IN
cord-018834-4ligp4ak	259	2	addition	addition	NN
cord-018834-4ligp4ak	259	3	,	,	,
cord-018834-4ligp4ak	259	4	it	-PRON-	PRP
cord-018834-4ligp4ak	259	5	maintains	maintain	VBZ
cord-018834-4ligp4ak	259	6	the	the	DT
cord-018834-4ligp4ak	259	7	vascular	vascular	JJ
cord-018834-4ligp4ak	259	8	barrier	barrier	NN
cord-018834-4ligp4ak	259	9	competency	competency	NN
cord-018834-4ligp4ak	259	10	,	,	,
cord-018834-4ligp4ak	259	11	prevents	prevent	VBZ
cord-018834-4ligp4ak	259	12	interstitial	interstitial	JJ
cord-018834-4ligp4ak	259	13	edema	edema	NN
cord-018834-4ligp4ak	259	14	,	,	,
cord-018834-4ligp4ak	259	15	and	and	CC
cord-018834-4ligp4ak	259	16	keeps	keep	VBZ
cord-018834-4ligp4ak	259	17	the	the	DT
cord-018834-4ligp4ak	259	18	integrity	integrity	NN
cord-018834-4ligp4ak	259	19	of	of	IN
cord-018834-4ligp4ak	259	20	the	the	DT
cord-018834-4ligp4ak	259	21	microcirculation	microcirculation	NN
cord-018834-4ligp4ak	259	22	[	[	-LRB-
cord-018834-4ligp4ak	259	23	64	64	CD
cord-018834-4ligp4ak	259	24	]	]	-RRB-
cord-018834-4ligp4ak	259	25	.	.	.
cord-018834-4ligp4ak	260	1	Oliver	Oliver	NNP
cord-018834-4ligp4ak	260	2	et	et	NNP
cord-018834-4ligp4ak	260	3	al	al	NNP
cord-018834-4ligp4ak	260	4	.	.	.
cord-018834-4ligp4ak	261	1	compared	compare	VBN
cord-018834-4ligp4ak	261	2	5	5	CD
cord-018834-4ligp4ak	261	3	%	%	NN
cord-018834-4ligp4ak	261	4	albumin	albumin	NN
cord-018834-4ligp4ak	261	5	priming	prime	VBG
cord-018834-4ligp4ak	261	6	with	with	IN
cord-018834-4ligp4ak	261	7	fresh	fresh	JJ
cord-018834-4ligp4ak	261	8	frozen	frozen	JJ
cord-018834-4ligp4ak	261	9	plasma	plasma	NN
cord-018834-4ligp4ak	261	10	(	(	-LRB-
cord-018834-4ligp4ak	261	11	FFP)based	ffp)base	VBN
cord-018834-4ligp4ak	261	12	priming	prime	VBG
cord-018834-4ligp4ak	261	13	in	in	IN
cord-018834-4ligp4ak	261	14	pediatric	pediatric	JJ
cord-018834-4ligp4ak	261	15	patients	patient	NNS
cord-018834-4ligp4ak	261	16	[	[	-LRB-
cord-018834-4ligp4ak	261	17	65	65	CD
cord-018834-4ligp4ak	261	18	]	]	-RRB-
cord-018834-4ligp4ak	261	19	.	.	.
cord-018834-4ligp4ak	262	1	Patients	patient	NNS
cord-018834-4ligp4ak	262	2	in	in	IN
cord-018834-4ligp4ak	262	3	the	the	DT
cord-018834-4ligp4ak	262	4	5	5	CD
cord-018834-4ligp4ak	262	5	%	%	NN
cord-018834-4ligp4ak	262	6	albumin	albumin	NN
cord-018834-4ligp4ak	262	7	group	group	NN
cord-018834-4ligp4ak	262	8	had	have	VBD
cord-018834-4ligp4ak	262	9	signifi	signifi	NNP
cord-018834-4ligp4ak	262	10	cantly	cantly	RB
cord-018834-4ligp4ak	262	11	lower	low	JJR
cord-018834-4ligp4ak	262	12	administration	administration	NN
cord-018834-4ligp4ak	262	13	of	of	IN
cord-018834-4ligp4ak	262	14	blood	blood	NN
cord-018834-4ligp4ak	262	15	products	product	NNS
cord-018834-4ligp4ak	262	16	.	.	.
cord-018834-4ligp4ak	263	1	It	-PRON-	PRP
cord-018834-4ligp4ak	263	2	was	be	VBD
cord-018834-4ligp4ak	263	3	shown	show	VBN
cord-018834-4ligp4ak	263	4	that	that	IN
cord-018834-4ligp4ak	263	5	using	use	VBG
cord-018834-4ligp4ak	263	6	albumin	albumin	NN
cord-018834-4ligp4ak	263	7	for	for	IN
cord-018834-4ligp4ak	263	8	the	the	DT
cord-018834-4ligp4ak	263	9	priming	priming	NN
cord-018834-4ligp4ak	263	10	volume	volume	NN
cord-018834-4ligp4ak	263	11	,	,	,
cord-018834-4ligp4ak	263	12	a	a	DT
cord-018834-4ligp4ak	263	13	dilution	dilution	NN
cord-018834-4ligp4ak	263	14	of	of	IN
cord-018834-4ligp4ak	263	15	coagulation	coagulation	NN
cord-018834-4ligp4ak	263	16	factors	factor	NNS
cord-018834-4ligp4ak	263	17	is	be	VBZ
cord-018834-4ligp4ak	263	18	accepted	accept	VBN
cord-018834-4ligp4ak	263	19	during	during	IN
cord-018834-4ligp4ak	263	20	CPB	CPB	NNP
cord-018834-4ligp4ak	263	21	.	.	.
cord-018834-4ligp4ak	264	1	This	this	DT
cord-018834-4ligp4ak	264	2	will	will	MD
cord-018834-4ligp4ak	264	3	lead	lead	VB
cord-018834-4ligp4ak	264	4	to	to	IN
cord-018834-4ligp4ak	264	5	less	less	RBR
cord-018834-4ligp4ak	264	6	thrombin	thrombin	JJ
cord-018834-4ligp4ak	264	7	generation	generation	NN
cord-018834-4ligp4ak	264	8	and	and	CC
cord-018834-4ligp4ak	264	9	consumption	consumption	NN
cord-018834-4ligp4ak	264	10	of	of	IN
cord-018834-4ligp4ak	264	11	coagulation	coagulation	NN
cord-018834-4ligp4ak	264	12	factors	factor	NNS
cord-018834-4ligp4ak	264	13	and	and	CC
cord-018834-4ligp4ak	264	14	the	the	DT
cord-018834-4ligp4ak	264	15	FFP	FFP	NNP
cord-018834-4ligp4ak	264	16	will	will	MD
cord-018834-4ligp4ak	264	17	be	be	VB
cord-018834-4ligp4ak	264	18	supplemented	supplement	VBN
cord-018834-4ligp4ak	264	19	after	after	IN
cord-018834-4ligp4ak	264	20	protamine	protamine	NNP
cord-018834-4ligp4ak	264	21	administration	administration	NNP
cord-018834-4ligp4ak	264	22	.	.	.
cord-018834-4ligp4ak	265	1	However	however	RB
cord-018834-4ligp4ak	265	2	,	,	,
cord-018834-4ligp4ak	265	3	the	the	DT
cord-018834-4ligp4ak	265	4	use	use	NN
cord-018834-4ligp4ak	265	5	of	of	IN
cord-018834-4ligp4ak	265	6	FFP	FFP	NNP
cord-018834-4ligp4ak	265	7	as	as	IN
cord-018834-4ligp4ak	265	8	a	a	DT
cord-018834-4ligp4ak	265	9	priming	priming	NN
cord-018834-4ligp4ak	265	10	solution	solution	NN
cord-018834-4ligp4ak	265	11	will	will	MD
cord-018834-4ligp4ak	265	12	result	result	VB
cord-018834-4ligp4ak	265	13	in	in	IN
cord-018834-4ligp4ak	265	14	enhancing	enhance	VBG
cord-018834-4ligp4ak	265	15	the	the	DT
cord-018834-4ligp4ak	265	16	thrombin	thrombin	JJ
cord-018834-4ligp4ak	265	17	formation	formation	NN
cord-018834-4ligp4ak	265	18	during	during	IN
cord-018834-4ligp4ak	265	19	CPB	CPB	NNP
cord-018834-4ligp4ak	265	20	,	,	,
cord-018834-4ligp4ak	265	21	thereby	thereby	RB
cord-018834-4ligp4ak	265	22	more	more	JJR
cord-018834-4ligp4ak	265	23	heparin	heparin	NN
cord-018834-4ligp4ak	265	24	is	be	VBZ
cord-018834-4ligp4ak	265	25	needed	need	VBN
cord-018834-4ligp4ak	265	26	and	and	CC
cord-018834-4ligp4ak	265	27	more	more	JJR
cord-018834-4ligp4ak	265	28	consumption	consumption	NN
cord-018834-4ligp4ak	265	29	of	of	IN
cord-018834-4ligp4ak	265	30	coagulation	coagulation	NN
cord-018834-4ligp4ak	265	31	factors	factor	NNS
cord-018834-4ligp4ak	265	32	is	be	VBZ
cord-018834-4ligp4ak	265	33	triggered	trigger	VBN
cord-018834-4ligp4ak	265	34	.	.	.
cord-018834-4ligp4ak	266	1	The	the	DT
cord-018834-4ligp4ak	266	2	use	use	NN
cord-018834-4ligp4ak	266	3	of	of	IN
cord-018834-4ligp4ak	266	4	albumin	albumin	NN
cord-018834-4ligp4ak	266	5	in	in	IN
cord-018834-4ligp4ak	266	6	priming	prime	VBG
cord-018834-4ligp4ak	266	7	the	the	DT
cord-018834-4ligp4ak	266	8	adult	adult	NN
cord-018834-4ligp4ak	266	9	CPB	CPB	NNP
cord-018834-4ligp4ak	266	10	may	may	MD
cord-018834-4ligp4ak	266	11	compete	compete	VB
cord-018834-4ligp4ak	266	12	with	with	IN
cord-018834-4ligp4ak	266	13	fi	fi	NNP
cord-018834-4ligp4ak	266	14	brinogen	brinogen	NNP
cord-018834-4ligp4ak	266	15	in	in	IN
cord-018834-4ligp4ak	266	16	the	the	DT
cord-018834-4ligp4ak	266	17	formation	formation	NN
cord-018834-4ligp4ak	266	18	of	of	IN
cord-018834-4ligp4ak	266	19	the	the	DT
cord-018834-4ligp4ak	266	20	protein	protein	NN
cord-018834-4ligp4ak	266	21	layer	layer	NN
cord-018834-4ligp4ak	266	22	coating	coat	VBG
cord-018834-4ligp4ak	266	23	the	the	DT
cord-018834-4ligp4ak	266	24	circuit	circuit	NN
cord-018834-4ligp4ak	266	25	and	and	CC
cord-018834-4ligp4ak	266	26	the	the	DT
cord-018834-4ligp4ak	266	27	oxygenator	oxygenator	NN
cord-018834-4ligp4ak	266	28	,	,	,
cord-018834-4ligp4ak	266	29	and	and	CC
cord-018834-4ligp4ak	266	30	the	the	DT
cord-018834-4ligp4ak	266	31	preadsorption	preadsorption	NN
cord-018834-4ligp4ak	266	32	of	of	IN
cord-018834-4ligp4ak	266	33	albumin	albumin	NN
cord-018834-4ligp4ak	266	34	prevents	prevent	VBZ
cord-018834-4ligp4ak	266	35	fi	fi	NNP
cord-018834-4ligp4ak	266	36	brinogen	brinogen	NNP
cord-018834-4ligp4ak	266	37	adsorption	adsorption	NN
cord-018834-4ligp4ak	266	38	and	and	CC
cord-018834-4ligp4ak	266	39	platelet	platelet	NN
cord-018834-4ligp4ak	266	40	adhesion	adhesion	NN
cord-018834-4ligp4ak	266	41	.	.	.
cord-018834-4ligp4ak	267	1	Russell	Russell	NNP
cord-018834-4ligp4ak	267	2	et	et	NNP
cord-018834-4ligp4ak	267	3	al	al	NNP
cord-018834-4ligp4ak	267	4	.	.	NNP
cord-018834-4ligp4ak	267	5	have	have	VBP
cord-018834-4ligp4ak	267	6	shown	show	VBN
cord-018834-4ligp4ak	267	7	in	in	IN
cord-018834-4ligp4ak	267	8	their	-PRON-	PRP$
cord-018834-4ligp4ak	267	9	meta	meta	JJ
cord-018834-4ligp4ak	267	10	-	-	HYPH
cord-018834-4ligp4ak	267	11	analysis	analysis	NN
cord-018834-4ligp4ak	267	12	that	that	WDT
cord-018834-4ligp4ak	267	13	albumin	albumin	NN
cord-018834-4ligp4ak	267	14	compared	compare	VBN
cord-018834-4ligp4ak	267	15	with	with	IN
cord-018834-4ligp4ak	267	16	crystalloids	crystalloid	NNS
cord-018834-4ligp4ak	267	17	as	as	IN
cord-018834-4ligp4ak	267	18	a	a	DT
cord-018834-4ligp4ak	267	19	priming	priming	NN
cord-018834-4ligp4ak	267	20	solution	solution	NN
cord-018834-4ligp4ak	267	21	exerts	exert	VBZ
cord-018834-4ligp4ak	267	22	a	a	DT
cord-018834-4ligp4ak	267	23	number	number	NN
cord-018834-4ligp4ak	267	24	of	of	IN
cord-018834-4ligp4ak	267	25	benefi	benefi	JJ
cord-018834-4ligp4ak	267	26	cial	cial	JJ
cord-018834-4ligp4ak	267	27	effects	effect	NNS
cord-018834-4ligp4ak	267	28	,	,	,
cord-018834-4ligp4ak	267	29	including	include	VBG
cord-018834-4ligp4ak	267	30	platelet	platelet	NN
cord-018834-4ligp4ak	267	31	count	count	NN
cord-018834-4ligp4ak	267	32	and	and	CC
cord-018834-4ligp4ak	267	33	colloid	colloid	NN
cord-018834-4ligp4ak	267	34	osmotic	osmotic	JJ
cord-018834-4ligp4ak	267	35	preservation	preservation	NN
cord-018834-4ligp4ak	267	36	[	[	-LRB-
cord-018834-4ligp4ak	267	37	66	66	CD
cord-018834-4ligp4ak	267	38	]	]	-RRB-
cord-018834-4ligp4ak	267	39	.	.	.
cord-018834-4ligp4ak	268	1	The	the	DT
cord-018834-4ligp4ak	268	2	use	use	NN
cord-018834-4ligp4ak	268	3	of	of	IN
cord-018834-4ligp4ak	268	4	albumin	albumin	NN
cord-018834-4ligp4ak	268	5	in	in	IN
cord-018834-4ligp4ak	268	6	the	the	DT
cord-018834-4ligp4ak	268	7	postoperative	postoperative	JJ
cord-018834-4ligp4ak	268	8	period	period	NN
cord-018834-4ligp4ak	268	9	after	after	IN
cord-018834-4ligp4ak	268	10	cardiac	cardiac	JJ
cord-018834-4ligp4ak	268	11	surgery	surgery	NN
cord-018834-4ligp4ak	268	12	has	have	VBZ
cord-018834-4ligp4ak	268	13	resulted	result	VBN
cord-018834-4ligp4ak	268	14	in	in	IN
cord-018834-4ligp4ak	268	15	the	the	DT
cord-018834-4ligp4ak	268	16	preservation	preservation	NN
cord-018834-4ligp4ak	268	17	in	in	IN
cord-018834-4ligp4ak	268	18	clot	clot	NN
cord-018834-4ligp4ak	268	19	formation	formation	NN
cord-018834-4ligp4ak	268	20	time	time	NN
cord-018834-4ligp4ak	268	21	and	and	CC
cord-018834-4ligp4ak	268	22	maximum	maximum	JJ
cord-018834-4ligp4ak	268	23	clot	clot	NN
cord-018834-4ligp4ak	268	24	fi	fi	NN
cord-018834-4ligp4ak	268	25	rmness	rmness	NN
cord-018834-4ligp4ak	268	26	.	.	.
cord-018834-4ligp4ak	269	1	However	however	RB
cord-018834-4ligp4ak	269	2	,	,	,
cord-018834-4ligp4ak	269	3	the	the	DT
cord-018834-4ligp4ak	269	4	use	use	NN
cord-018834-4ligp4ak	269	5	of	of	IN
cord-018834-4ligp4ak	269	6	low	low	JJ
cord-018834-4ligp4ak	269	7	molar	molar	JJ
cord-018834-4ligp4ak	269	8	hydroxyethyl	hydroxyethyl	NN
cord-018834-4ligp4ak	269	9	starch	starch	NN
cord-018834-4ligp4ak	269	10	solutions	solution	NNS
cord-018834-4ligp4ak	269	11	(	(	-LRB-
cord-018834-4ligp4ak	269	12	HES	HES	NNP
cord-018834-4ligp4ak	269	13	)	)	-RRB-
cord-018834-4ligp4ak	269	14	(	(	-LRB-
cord-018834-4ligp4ak	269	15	6	6	CD
cord-018834-4ligp4ak	269	16	%	%	NN
cord-018834-4ligp4ak	269	17	200/0.5	200/0.5	CD
cord-018834-4ligp4ak	269	18	or	or	CC
cord-018834-4ligp4ak	269	19	130/0.4	130/0.4	CD
cord-018834-4ligp4ak	269	20	)	)	-RRB-
cord-018834-4ligp4ak	269	21	resulted	result	VBD
cord-018834-4ligp4ak	269	22	in	in	IN
cord-018834-4ligp4ak	269	23	prolongation	prolongation	NN
cord-018834-4ligp4ak	269	24	in	in	IN
cord-018834-4ligp4ak	269	25	clot	clot	NN
cord-018834-4ligp4ak	269	26	formation	formation	NN
cord-018834-4ligp4ak	269	27	time	time	NN
cord-018834-4ligp4ak	269	28	and	and	CC
cord-018834-4ligp4ak	269	29	reduction	reduction	NN
cord-018834-4ligp4ak	269	30	in	in	IN
cord-018834-4ligp4ak	269	31	maximum	maximum	JJ
cord-018834-4ligp4ak	269	32	clot	clot	NN
cord-018834-4ligp4ak	269	33	fi	fi	NN
cord-018834-4ligp4ak	269	34	rmness	rmness	NN
cord-018834-4ligp4ak	269	35	[	[	-LRB-
cord-018834-4ligp4ak	269	36	67	67	CD
cord-018834-4ligp4ak	269	37	]	]	-RRB-
cord-018834-4ligp4ak	269	38	.	.	.
cord-018834-4ligp4ak	270	1	Moreover	moreover	RB
cord-018834-4ligp4ak	270	2	,	,	,
cord-018834-4ligp4ak	270	3	the	the	DT
cord-018834-4ligp4ak	270	4	use	use	NN
cord-018834-4ligp4ak	270	5	of	of	IN
cord-018834-4ligp4ak	270	6	old	old	JJ
cord-018834-4ligp4ak	270	7	high	high	JJ
cord-018834-4ligp4ak	270	8	-	-	HYPH
cord-018834-4ligp4ak	270	9	molar	molar	NN
cord-018834-4ligp4ak	270	10	HES	hes	NN
cord-018834-4ligp4ak	270	11	and	and	CC
cord-018834-4ligp4ak	270	12	gelatin	gelatin	NN
cord-018834-4ligp4ak	270	13	solutions	solution	NNS
cord-018834-4ligp4ak	270	14	correlated	correlate	VBN
cord-018834-4ligp4ak	270	15	with	with	IN
cord-018834-4ligp4ak	270	16	the	the	DT
cord-018834-4ligp4ak	270	17	amount	amount	NN
cord-018834-4ligp4ak	270	18	of	of	IN
cord-018834-4ligp4ak	270	19	postoperative	postoperative	JJ
cord-018834-4ligp4ak	270	20	bleeding	bleeding	NN
cord-018834-4ligp4ak	270	21	after	after	IN
cord-018834-4ligp4ak	270	22	cardiac	cardiac	JJ
cord-018834-4ligp4ak	270	23	surgery	surgery	NN
cord-018834-4ligp4ak	270	24	,	,	,
cord-018834-4ligp4ak	270	25	but	but	CC
cord-018834-4ligp4ak	270	26	the	the	DT
cord-018834-4ligp4ak	270	27	use	use	NN
cord-018834-4ligp4ak	270	28	of	of	IN
cord-018834-4ligp4ak	270	29	4	4	CD
cord-018834-4ligp4ak	270	30	%	%	NN
cord-018834-4ligp4ak	270	31	albumin	albumin	NN
cord-018834-4ligp4ak	270	32	solution	solution	NN
cord-018834-4ligp4ak	270	33	did	do	VBD
cord-018834-4ligp4ak	270	34	not	not	RB
cord-018834-4ligp4ak	270	35	[	[	-LRB-
cord-018834-4ligp4ak	270	36	68	68	CD
cord-018834-4ligp4ak	270	37	]	]	-RRB-
cord-018834-4ligp4ak	270	38	.	.	.
cord-018834-4ligp4ak	271	1	The	the	DT
cord-018834-4ligp4ak	271	2	same	same	JJ
cord-018834-4ligp4ak	271	3	results	result	NNS
cord-018834-4ligp4ak	271	4	have	have	VBP
cord-018834-4ligp4ak	271	5	been	be	VBN
cord-018834-4ligp4ak	271	6	confi	confi	VBN
cord-018834-4ligp4ak	271	7	rmed	rme	VBN
cord-018834-4ligp4ak	271	8	in	in	IN
cord-018834-4ligp4ak	271	9	a	a	DT
cord-018834-4ligp4ak	271	10	metaanalysis	metaanalysis	NN
cord-018834-4ligp4ak	271	11	comparing	compare	VBG
cord-018834-4ligp4ak	271	12	the	the	DT
cord-018834-4ligp4ak	271	13	use	use	NN
cord-018834-4ligp4ak	271	14	of	of	IN
cord-018834-4ligp4ak	271	15	HES	HES	NNP
cord-018834-4ligp4ak	271	16	solutions	solution	NNS
cord-018834-4ligp4ak	271	17	with	with	IN
cord-018834-4ligp4ak	271	18	albumin	albumin	NN
cord-018834-4ligp4ak	271	19	.	.	.
cord-018834-4ligp4ak	272	1	Hemodynamics	hemodynamic	NNS
cord-018834-4ligp4ak	272	2	were	be	VBD
cord-018834-4ligp4ak	272	3	similar	similar	JJ
cord-018834-4ligp4ak	272	4	in	in	IN
cord-018834-4ligp4ak	272	5	both	both	DT
cord-018834-4ligp4ak	272	6	groups	group	NNS
cord-018834-4ligp4ak	272	7	,	,	,
cord-018834-4ligp4ak	272	8	but	but	CC
cord-018834-4ligp4ak	272	9	the	the	DT
cord-018834-4ligp4ak	272	10	use	use	NN
cord-018834-4ligp4ak	272	11	of	of	IN
cord-018834-4ligp4ak	272	12	albumin	albumin	NN
cord-018834-4ligp4ak	272	13	decreased	decrease	VBD
cord-018834-4ligp4ak	272	14	blood	blood	NN
cord-018834-4ligp4ak	272	15	loss	loss	NN
cord-018834-4ligp4ak	272	16	,	,	,
cord-018834-4ligp4ak	272	17	the	the	DT
cord-018834-4ligp4ak	272	18	amount	amount	NN
cord-018834-4ligp4ak	272	19	of	of	IN
cord-018834-4ligp4ak	272	20	blood	blood	NN
cord-018834-4ligp4ak	272	21	products	product	NNS
cord-018834-4ligp4ak	272	22	transfusions	transfusion	NNS
cord-018834-4ligp4ak	272	23	,	,	,
cord-018834-4ligp4ak	272	24	and	and	CC
cord-018834-4ligp4ak	272	25	the	the	DT
cord-018834-4ligp4ak	272	26	need	need	NN
cord-018834-4ligp4ak	272	27	for	for	IN
cord-018834-4ligp4ak	272	28	reoperation	reoperation	NN
cord-018834-4ligp4ak	272	29	postoperatively	postoperatively	RB
cord-018834-4ligp4ak	272	30	[	[	-LRB-
cord-018834-4ligp4ak	272	31	69	69	CD
cord-018834-4ligp4ak	272	32	]	]	-RRB-
cord-018834-4ligp4ak	272	33	.	.	.
cord-018834-4ligp4ak	273	1	The	the	DT
cord-018834-4ligp4ak	273	2	presence	presence	NN
cord-018834-4ligp4ak	273	3	of	of	IN
cord-018834-4ligp4ak	273	4	hypoalbuminemia	hypoalbuminemia	NNP
cord-018834-4ligp4ak	273	5	(	(	-LRB-
cord-018834-4ligp4ak	273	6	cutoff	cutoff	NNP
cord-018834-4ligp4ak	273	7	18	18	CD
cord-018834-4ligp4ak	273	8	g	g	NNP
cord-018834-4ligp4ak	273	9	/	/	SYM
cord-018834-4ligp4ak	273	10	L	L	NNP
cord-018834-4ligp4ak	273	11	)	)	-RRB-
cord-018834-4ligp4ak	273	12	after	after	IN
cord-018834-4ligp4ak	273	13	cardiac	cardiac	JJ
cord-018834-4ligp4ak	273	14	surgery	surgery	NN
cord-018834-4ligp4ak	273	15	was	be	VBD
cord-018834-4ligp4ak	273	16	found	find	VBN
cord-018834-4ligp4ak	273	17	to	to	TO
cord-018834-4ligp4ak	273	18	be	be	VB
cord-018834-4ligp4ak	273	19	a	a	DT
cord-018834-4ligp4ak	273	20	better	well	JJR
cord-018834-4ligp4ak	273	21	predictor	predictor	NN
cord-018834-4ligp4ak	273	22	for	for	IN
cord-018834-4ligp4ak	273	23	mortality	mortality	NN
cord-018834-4ligp4ak	273	24	after	after	IN
cord-018834-4ligp4ak	273	25	cardiac	cardiac	JJ
cord-018834-4ligp4ak	273	26	surgery	surgery	NN
cord-018834-4ligp4ak	274	1	-even	-even	:
cord-018834-4ligp4ak	274	2	better	well	RBR
cord-018834-4ligp4ak	274	3	than	than	IN
cord-018834-4ligp4ak	274	4	EUROscore	euroscore	VB
cord-018834-4ligp4ak	274	5	[	[	-LRB-
cord-018834-4ligp4ak	274	6	70	70	CD
cord-018834-4ligp4ak	274	7	]	]	-RRB-
cord-018834-4ligp4ak	274	8	.	.	.
cord-018834-4ligp4ak	275	1	In	in	IN
cord-018834-4ligp4ak	275	2	a	a	DT
cord-018834-4ligp4ak	275	3	recently	recently	RB
cord-018834-4ligp4ak	275	4	published	publish	VBN
cord-018834-4ligp4ak	275	5	prospective	prospective	JJ
cord-018834-4ligp4ak	275	6	,	,	,
cord-018834-4ligp4ak	275	7	randomized	randomized	JJ
cord-018834-4ligp4ak	275	8	,	,	,
cord-018834-4ligp4ak	275	9	double	double	JJ
cord-018834-4ligp4ak	275	10	-	-	HYPH
cord-018834-4ligp4ak	275	11	blind	blind	JJ
cord-018834-4ligp4ak	275	12	,	,	,
cord-018834-4ligp4ak	275	13	placebocontrolled	placebocontrolled	JJ
cord-018834-4ligp4ak	275	14	trial	trial	NN
cord-018834-4ligp4ak	275	15	,	,	,
cord-018834-4ligp4ak	275	16	the	the	DT
cord-018834-4ligp4ak	275	17	preemptive	preemptive	JJ
cord-018834-4ligp4ak	275	18	correction	correction	NN
cord-018834-4ligp4ak	275	19	of	of	IN
cord-018834-4ligp4ak	275	20	a	a	DT
cord-018834-4ligp4ak	275	21	low	low	JJ
cord-018834-4ligp4ak	275	22	preoperative	preoperative	JJ
cord-018834-4ligp4ak	275	23	albumin	albumin	NN
cord-018834-4ligp4ak	275	24	level	level	NN
cord-018834-4ligp4ak	275	25	by	by	IN
cord-018834-4ligp4ak	275	26	administering	administer	VBG
cord-018834-4ligp4ak	275	27	HSA	HSA	NNP
cord-018834-4ligp4ak	275	28	in	in	IN
cord-018834-4ligp4ak	275	29	patients	patient	NNS
cord-018834-4ligp4ak	275	30	undergoing	undergo	VBG
cord-018834-4ligp4ak	275	31	off	off	IN
cord-018834-4ligp4ak	275	32	-	-	HYPH
cord-018834-4ligp4ak	275	33	pump	pump	NN
cord-018834-4ligp4ak	275	34	coronary	coronary	JJ
cord-018834-4ligp4ak	275	35	artery	artery	NN
cord-018834-4ligp4ak	275	36	bypass	bypass	NN
cord-018834-4ligp4ak	275	37	(	(	-LRB-
cord-018834-4ligp4ak	275	38	OPCAB	OPCAB	NNP
cord-018834-4ligp4ak	275	39	)	)	-RRB-
cord-018834-4ligp4ak	276	1	is	be	VBZ
cord-018834-4ligp4ak	276	2	associated	associate	VBN
cord-018834-4ligp4ak	276	3	signifi	signifi	NNP
cord-018834-4ligp4ak	276	4	ca	can	MD
cord-018834-4ligp4ak	276	5	nt	not	RB
cord-018834-4ligp4ak	276	6	reduction	reduction	VB
cord-018834-4ligp4ak	276	7	in	in	IN
cord-018834-4ligp4ak	276	8	the	the	DT
cord-018834-4ligp4ak	276	9	incidence	incidence	NN
cord-018834-4ligp4ak	276	10	of	of	IN
cord-018834-4ligp4ak	276	11	AKI	AKI	NNP
cord-018834-4ligp4ak	276	12	,	,	,
cord-018834-4ligp4ak	276	13	from	from	IN
cord-018834-4ligp4ak	276	14	26	26	CD
cord-018834-4ligp4ak	276	15	%	%	NN
cord-018834-4ligp4ak	276	16	in	in	IN
cord-018834-4ligp4ak	276	17	the	the	DT
cord-018834-4ligp4ak	276	18	control	control	NN
cord-018834-4ligp4ak	276	19	group	group	NN
cord-018834-4ligp4ak	276	20	to	to	IN
cord-018834-4ligp4ak	276	21	13.7	13.7	CD
cord-018834-4ligp4ak	276	22	%	%	NN
cord-018834-4ligp4ak	276	23	in	in	IN
cord-018834-4ligp4ak	276	24	the	the	DT
cord-018834-4ligp4ak	276	25	albumin	albumin	NN
cord-018834-4ligp4ak	276	26	group	group	NN
cord-018834-4ligp4ak	276	27	.	.	.
cord-018834-4ligp4ak	277	1	The	the	DT
cord-018834-4ligp4ak	277	2	editorial	editorial	NN
cord-018834-4ligp4ak	277	3	that	that	WDT
cord-018834-4ligp4ak	277	4	accompanied	accompany	VBD
cord-018834-4ligp4ak	277	5	the	the	DT
cord-018834-4ligp4ak	277	6	study	study	NN
cord-018834-4ligp4ak	277	7	has	have	VBZ
cord-018834-4ligp4ak	277	8	suggested	suggest	VBN
cord-018834-4ligp4ak	277	9	that	that	IN
cord-018834-4ligp4ak	277	10	restoring	restore	VBG
cord-018834-4ligp4ak	277	11	the	the	DT
cord-018834-4ligp4ak	277	12	target	target	NN
cord-018834-4ligp4ak	277	13	level	level	NN
cord-018834-4ligp4ak	277	14	is	be	VBZ
cord-018834-4ligp4ak	277	15	associated	associate	VBN
cord-018834-4ligp4ak	277	16	with	with	IN
cord-018834-4ligp4ak	277	17	reduction	reduction	NN
cord-018834-4ligp4ak	277	18	in	in	IN
cord-018834-4ligp4ak	277	19	AKI	AKI	NNP
cord-018834-4ligp4ak	277	20	in	in	IN
cord-018834-4ligp4ak	277	21	amplitude	amplitude	NN
cord-018834-4ligp4ak	277	22	greater	great	JJR
cord-018834-4ligp4ak	277	23	than	than	IN
cord-018834-4ligp4ak	277	24	that	that	DT
cord-018834-4ligp4ak	277	25	of	of	IN
cord-018834-4ligp4ak	277	26	any	any	DT
cord-018834-4ligp4ak	277	27	known	know	VBN
cord-018834-4ligp4ak	277	28	intervention	intervention	NN
cord-018834-4ligp4ak	277	29	in	in	IN
cord-018834-4ligp4ak	277	30	patients	patient	NNS
cord-018834-4ligp4ak	277	31	undergoing	undergo	VBG
cord-018834-4ligp4ak	277	32	OPCAB	OPCAB	NNP
cord-018834-4ligp4ak	277	33	[	[	-LRB-
cord-018834-4ligp4ak	277	34	71	71	CD
cord-018834-4ligp4ak	277	35	,	,	,
cord-018834-4ligp4ak	277	36	72	72	CD
cord-018834-4ligp4ak	277	37	]	]	-RRB-
cord-018834-4ligp4ak	277	38	.	.	.
cord-018834-4ligp4ak	278	1	Edwin	Edwin	NNP
cord-018834-4ligp4ak	278	2	Cohn	Cohn	NNP
cord-018834-4ligp4ak	278	3	's	's	POS
cord-018834-4ligp4ak	278	4	development	development	NN
cord-018834-4ligp4ak	278	5	of	of	IN
cord-018834-4ligp4ak	278	6	stable	stable	JJ
cord-018834-4ligp4ak	278	7	albumin	albumin	NN
cord-018834-4ligp4ak	278	8	solution	solution	NN
cord-018834-4ligp4ak	278	9	during	during	IN
cord-018834-4ligp4ak	278	10	World	World	NNP
cord-018834-4ligp4ak	278	11	War	War	NNP
cord-018834-4ligp4ak	278	12	II	II	NNP
cord-018834-4ligp4ak	278	13	was	be	VBD
cord-018834-4ligp4ak	278	14	based	base	VBN
cord-018834-4ligp4ak	278	15	on	on	IN
cord-018834-4ligp4ak	278	16	a	a	DT
cord-018834-4ligp4ak	278	17	fractionation	fractionation	NN
cord-018834-4ligp4ak	278	18	scheme	scheme	NN
cord-018834-4ligp4ak	278	19	,	,	,
cord-018834-4ligp4ak	278	20	which	which	WDT
cord-018834-4ligp4ak	278	21	was	be	VBD
cord-018834-4ligp4ak	278	22	rapidly	rapidly	RB
cord-018834-4ligp4ak	278	23	adopted	adopt	VBN
cord-018834-4ligp4ak	278	24	by	by	IN
cord-018834-4ligp4ak	278	25	a	a	DT
cord-018834-4ligp4ak	278	26	number	number	NN
cord-018834-4ligp4ak	278	27	of	of	IN
cord-018834-4ligp4ak	278	28	pharmaceutical	pharmaceutical	JJ
cord-018834-4ligp4ak	278	29	companies	company	NNS
cord-018834-4ligp4ak	278	30	.	.	.
cord-018834-4ligp4ak	279	1	The	the	DT
cord-018834-4ligp4ak	279	2	pasteurization	pasteurization	NN
cord-018834-4ligp4ak	279	3	technique	technique	NN
cord-018834-4ligp4ak	279	4	used	use	VBN
cord-018834-4ligp4ak	279	5	in	in	IN
cord-018834-4ligp4ak	279	6	albumin	albumin	NN
cord-018834-4ligp4ak	279	7	solutions	solution	NNS
cord-018834-4ligp4ak	279	8	production	production	NN
cord-018834-4ligp4ak	279	9	is	be	VBZ
cord-018834-4ligp4ak	279	10	very	very	RB
cord-018834-4ligp4ak	279	11	effective	effective	JJ
cord-018834-4ligp4ak	279	12	in	in	IN
cord-018834-4ligp4ak	279	13	eliminating	eliminate	VBG
cord-018834-4ligp4ak	279	14	the	the	DT
cord-018834-4ligp4ak	279	15	risk	risk	NN
cord-018834-4ligp4ak	279	16	for	for	IN
cord-018834-4ligp4ak	279	17	viral	viral	JJ
cord-018834-4ligp4ak	279	18	and	and	CC
cord-018834-4ligp4ak	279	19	bacterial	bacterial	JJ
cord-018834-4ligp4ak	279	20	infections	infection	NNS
cord-018834-4ligp4ak	279	21	.	.	.
cord-018834-4ligp4ak	280	1	Moreover	moreover	RB
cord-018834-4ligp4ak	280	2	,	,	,
cord-018834-4ligp4ak	280	3	the	the	DT
cord-018834-4ligp4ak	280	4	recent	recent	JJ
cord-018834-4ligp4ak	280	5	introduction	introduction	NN
cord-018834-4ligp4ak	280	6	of	of	IN
cord-018834-4ligp4ak	280	7	ion	ion	NN
cord-018834-4ligp4ak	280	8	exchange	exchange	NN
cord-018834-4ligp4ak	280	9	chromatography	chromatography	NN
cord-018834-4ligp4ak	280	10	in	in	IN
cord-018834-4ligp4ak	280	11	the	the	DT
cord-018834-4ligp4ak	280	12	production	production	NN
cord-018834-4ligp4ak	280	13	of	of	IN
cord-018834-4ligp4ak	280	14	albumin	albumin	NN
cord-018834-4ligp4ak	280	15	is	be	VBZ
cord-018834-4ligp4ak	280	16	very	very	RB
cord-018834-4ligp4ak	280	17	effective	effective	JJ
cord-018834-4ligp4ak	280	18	in	in	IN
cord-018834-4ligp4ak	280	19	reducing	reduce	VBG
cord-018834-4ligp4ak	280	20	the	the	DT
cord-018834-4ligp4ak	280	21	risk	risk	NN
cord-018834-4ligp4ak	280	22	of	of	IN
cord-018834-4ligp4ak	280	23	prion	prion	NN
cord-018834-4ligp4ak	280	24	disease	disease	NN
cord-018834-4ligp4ak	280	25	transmission	transmission	NN
cord-018834-4ligp4ak	280	26	by	by	IN
cord-018834-4ligp4ak	280	27	albumin	albumin	NN
cord-018834-4ligp4ak	280	28	solutions	solution	NNS
cord-018834-4ligp4ak	280	29	[	[	-LRB-
cord-018834-4ligp4ak	280	30	73	73	CD
cord-018834-4ligp4ak	280	31	]	]	-RRB-
cord-018834-4ligp4ak	280	32	.	.	.
cord-018834-4ligp4ak	281	1	The	the	DT
cord-018834-4ligp4ak	281	2	use	use	NN
cord-018834-4ligp4ak	281	3	of	of	IN
cord-018834-4ligp4ak	281	4	albumin	albumin	NN
cord-018834-4ligp4ak	281	5	is	be	VBZ
cord-018834-4ligp4ak	281	6	considered	consider	VBN
cord-018834-4ligp4ak	281	7	safe	safe	JJ
cord-018834-4ligp4ak	281	8	practice	practice	NN
cord-018834-4ligp4ak	281	9	;	;	:
cord-018834-4ligp4ak	281	10	in	in	IN
cord-018834-4ligp4ak	281	11	a	a	DT
cord-018834-4ligp4ak	281	12	study	study	NN
cord-018834-4ligp4ak	281	13	evaluating	evaluate	VBG
cord-018834-4ligp4ak	281	14	adverse	adverse	JJ
cord-018834-4ligp4ak	281	15	event	event	NN
cord-018834-4ligp4ak	281	16	reporting	report	VBG
cord-018834-4ligp4ak	281	17	between	between	IN
cord-018834-4ligp4ak	281	18	1998	1998	CD
cord-018834-4ligp4ak	281	19	and	and	CC
cord-018834-4ligp4ak	281	20	2000	2000	CD
cord-018834-4ligp4ak	281	21	,	,	,
cord-018834-4ligp4ak	281	22	the	the	DT
cord-018834-4ligp4ak	281	23	incidence	incidence	NN
cord-018834-4ligp4ak	281	24	of	of	IN
cord-018834-4ligp4ak	281	25	all	all	DT
cord-018834-4ligp4ak	281	26	reported	report	VBN
cord-018834-4ligp4ak	281	27	serious	serious	JJ
cord-018834-4ligp4ak	281	28	nonfatal	nonfatal	JJ
cord-018834-4ligp4ak	281	29	and	and	CC
cord-018834-4ligp4ak	281	30	fatal	fatal	JJ
cord-018834-4ligp4ak	281	31	adverse	adverse	JJ
cord-018834-4ligp4ak	281	32	events	event	NNS
cord-018834-4ligp4ak	281	33	was	be	VBD
cord-018834-4ligp4ak	281	34	just	just	RB
cord-018834-4ligp4ak	281	35	fi	fi	NNP
cord-018834-4ligp4ak	281	36	ve	ve	FW
cord-018834-4ligp4ak	281	37	per	per	IN
cord-018834-4ligp4ak	281	38	million	million	CD
cord-018834-4ligp4ak	281	39	doses	dose	NNS
cord-018834-4ligp4ak	281	40	,	,	,
cord-018834-4ligp4ak	281	41	and	and	CC
cord-018834-4ligp4ak	281	42	no	no	DT
cord-018834-4ligp4ak	281	43	patient	patient	JJ
cord-018834-4ligp4ak	281	44	death	death	NN
cord-018834-4ligp4ak	281	45	was	be	VBD
cord-018834-4ligp4ak	281	46	classifi	classifi	NNP
cord-018834-4ligp4ak	281	47	ed	ed	NNP
cord-018834-4ligp4ak	281	48	as	as	RB
cord-018834-4ligp4ak	281	49	probably	probably	RB
cord-018834-4ligp4ak	281	50	related	relate	VBN
cord-018834-4ligp4ak	281	51	to	to	IN
cord-018834-4ligp4ak	281	52	albumin	albumin	NN
cord-018834-4ligp4ak	281	53	administration	administration	NN
cord-018834-4ligp4ak	281	54	[	[	-LRB-
cord-018834-4ligp4ak	281	55	74	74	CD
cord-018834-4ligp4ak	281	56	]	]	-RRB-
cord-018834-4ligp4ak	281	57	.	.	.
cord-018834-4ligp4ak	282	1	Currently	currently	RB
cord-018834-4ligp4ak	282	2	available	available	JJ
cord-018834-4ligp4ak	282	3	human	human	JJ
cord-018834-4ligp4ak	282	4	albumin	albumin	NN
cord-018834-4ligp4ak	282	5	solutions	solution	NNS
cord-018834-4ligp4ak	282	6	may	may	MD
cord-018834-4ligp4ak	282	7	differ	differ	VB
cord-018834-4ligp4ak	282	8	in	in	IN
cord-018834-4ligp4ak	282	9	protein	protein	NN
cord-018834-4ligp4ak	282	10	content	content	NN
cord-018834-4ligp4ak	282	11	and	and	CC
cord-018834-4ligp4ak	282	12	composition	composition	NN
cord-018834-4ligp4ak	282	13	,	,	,
cord-018834-4ligp4ak	282	14	binding	bind	VBG
cord-018834-4ligp4ak	282	15	capacity	capacity	NN
cord-018834-4ligp4ak	282	16	,	,	,
cord-018834-4ligp4ak	282	17	metal	metal	NN
cord-018834-4ligp4ak	282	18	ion	ion	NN
cord-018834-4ligp4ak	282	19	content	content	NN
cord-018834-4ligp4ak	282	20	,	,	,
cord-018834-4ligp4ak	282	21	antioxidants	antioxidant	NNS
cord-018834-4ligp4ak	282	22	prosperities	prosperity	NNS
cord-018834-4ligp4ak	282	23	,	,	,
cord-018834-4ligp4ak	282	24	and	and	CC
cord-018834-4ligp4ak	282	25	capacity	capacity	NN
cord-018834-4ligp4ak	282	26	to	to	TO
cord-018834-4ligp4ak	282	27	bind	bind	VB
cord-018834-4ligp4ak	282	28	drugs	drug	NNS
cord-018834-4ligp4ak	282	29	[	[	-LRB-
cord-018834-4ligp4ak	282	30	75	75	CD
cord-018834-4ligp4ak	282	31	]	]	-RRB-
cord-018834-4ligp4ak	282	32	.	.	.
cord-018834-4ligp4ak	283	1	It	-PRON-	PRP
cord-018834-4ligp4ak	283	2	is	be	VBZ
cord-018834-4ligp4ak	283	3	noteworthy	noteworthy	JJ
cord-018834-4ligp4ak	283	4	to	to	TO
cord-018834-4ligp4ak	283	5	mention	mention	VB
cord-018834-4ligp4ak	283	6	that	that	IN
cord-018834-4ligp4ak	283	7	cysteine	cysteine	NN
cord-018834-4ligp4ak	283	8	34	34	CD
cord-018834-4ligp4ak	283	9	-the	-the	NFP
cord-018834-4ligp4ak	283	10	most	most	RBS
cord-018834-4ligp4ak	283	11	important	important	JJ
cord-018834-4ligp4ak	283	12	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	283	13	residue	residue	NN
cord-018834-4ligp4ak	283	14	in	in	IN
cord-018834-4ligp4ak	283	15	HSA	HSA	NNP
cord-018834-4ligp4ak	283	16	-is	-is	:
cord-018834-4ligp4ak	283	17	oxidized	oxidize	VBN
cord-018834-4ligp4ak	283	18	in	in	IN
cord-018834-4ligp4ak	283	19	23	23	CD
cord-018834-4ligp4ak	283	20	%	%	NN
cord-018834-4ligp4ak	283	21	of	of	IN
cord-018834-4ligp4ak	283	22	healthy	healthy	JJ
cord-018834-4ligp4ak	283	23	human	human	JJ
cord-018834-4ligp4ak	283	24	volunteers	volunteer	NNS
cord-018834-4ligp4ak	283	25	versus	versus	IN
cord-018834-4ligp4ak	283	26	54	54	CD
cord-018834-4ligp4ak	283	27	-	-	SYM
cord-018834-4ligp4ak	283	28	60	60	CD
cord-018834-4ligp4ak	283	29	%	%	NN
cord-018834-4ligp4ak	283	30	in	in	IN
cord-018834-4ligp4ak	283	31	commercial	commercial	JJ
cord-018834-4ligp4ak	283	32	preparations	preparation	NNS
cord-018834-4ligp4ak	283	33	[	[	-LRB-
cord-018834-4ligp4ak	283	34	76	76	CD
cord-018834-4ligp4ak	283	35	]	]	-RRB-
cord-018834-4ligp4ak	283	36	,	,	,
cord-018834-4ligp4ak	283	37	which	which	WDT
cord-018834-4ligp4ak	283	38	may	may	MD
cord-018834-4ligp4ak	283	39	infl	infl	VB
cord-018834-4ligp4ak	283	40	uence	uence	VB
cord-018834-4ligp4ak	283	41	the	the	DT
cord-018834-4ligp4ak	283	42	properties	property	NNS
cord-018834-4ligp4ak	283	43	and	and	CC
cord-018834-4ligp4ak	283	44	hence	hence	RB
cord-018834-4ligp4ak	283	45	the	the	DT
cord-018834-4ligp4ak	283	46	clinical	clinical	JJ
cord-018834-4ligp4ak	283	47	impact	impact	NN
cord-018834-4ligp4ak	283	48	of	of	IN
cord-018834-4ligp4ak	283	49	albumin	albumin	NN
cord-018834-4ligp4ak	283	50	solutions	solution	NNS
cord-018834-4ligp4ak	283	51	[	[	-LRB-
cord-018834-4ligp4ak	283	52	77	77	CD
cord-018834-4ligp4ak	283	53	]	]	-RRB-
cord-018834-4ligp4ak	283	54	.	.	.
cord-018834-4ligp4ak	284	1	Albumin	albumin	NN
cord-018834-4ligp4ak	284	2	solutions	solution	NNS
cord-018834-4ligp4ak	284	3	are	be	VBP
cord-018834-4ligp4ak	284	4	available	available	JJ
cord-018834-4ligp4ak	284	5	in	in	IN
cord-018834-4ligp4ak	284	6	a	a	DT
cord-018834-4ligp4ak	284	7	variety	variety	NN
cord-018834-4ligp4ak	284	8	of	of	IN
cord-018834-4ligp4ak	284	9	concentrations	concentration	NNS
cord-018834-4ligp4ak	284	10	,	,	,
cord-018834-4ligp4ak	284	11	mainly	mainly	RB
cord-018834-4ligp4ak	284	12	20	20	CD
cord-018834-4ligp4ak	284	13	-	-	SYM
cord-018834-4ligp4ak	284	14	25	25	CD
cord-018834-4ligp4ak	284	15	%	%	NN
cord-018834-4ligp4ak	284	16	or	or	CC
cord-018834-4ligp4ak	284	17	4	4	CD
cord-018834-4ligp4ak	284	18	-	-	SYM
cord-018834-4ligp4ak	284	19	5	5	CD
cord-018834-4ligp4ak	284	20	%	%	NN
cord-018834-4ligp4ak	284	21	.	.	.
cord-018834-4ligp4ak	285	1	Iso	iso	NN
cord-018834-4ligp4ak	285	2	-	-	HYPH
cord-018834-4ligp4ak	285	3	oncotic	oncotic	JJ
cord-018834-4ligp4ak	285	4	preparations	preparation	NNS
cord-018834-4ligp4ak	285	5	of	of	IN
cord-018834-4ligp4ak	285	6	HSA	HSA	NNP
cord-018834-4ligp4ak	285	7	are	be	VBP
cord-018834-4ligp4ak	285	8	more	more	RBR
cord-018834-4ligp4ak	285	9	effective	effective	JJ
cord-018834-4ligp4ak	285	10	than	than	IN
cord-018834-4ligp4ak	285	11	crystalloids	crystalloids	NNP
cord-018834-4ligp4ak	285	12	solutions	solution	NNS
cord-018834-4ligp4ak	285	13	in	in	IN
cord-018834-4ligp4ak	285	14	maintaining	maintain	VBG
cord-018834-4ligp4ak	285	15	the	the	DT
cord-018834-4ligp4ak	285	16	intravascular	intravascular	JJ
cord-018834-4ligp4ak	285	17	volume	volume	NN
cord-018834-4ligp4ak	285	18	(	(	-LRB-
cord-018834-4ligp4ak	285	19	>	>	NFP
cord-018834-4ligp4ak	285	20	80	80	CD
cord-018834-4ligp4ak	285	21	%	%	NN
cord-018834-4ligp4ak	285	22	vs.	vs.	IN
cord-018834-4ligp4ak	285	23	<	<	XX
cord-018834-4ligp4ak	285	24	20	20	CD
cord-018834-4ligp4ak	285	25	%	%	NN
cord-018834-4ligp4ak	285	26	)	)	-RRB-
cord-018834-4ligp4ak	286	1	[	[	-LRB-
cord-018834-4ligp4ak	286	2	78	78	CD
cord-018834-4ligp4ak	286	3	]	]	-RRB-
cord-018834-4ligp4ak	286	4	.	.	.
cord-018834-4ligp4ak	287	1	Hypertonic	Hypertonic	NNP
cord-018834-4ligp4ak	287	2	albumin	albumin	NN
cord-018834-4ligp4ak	287	3	(	(	-LRB-
cord-018834-4ligp4ak	287	4	20	20	CD
cord-018834-4ligp4ak	287	5	-	-	SYM
cord-018834-4ligp4ak	287	6	25	25	CD
cord-018834-4ligp4ak	287	7	%	%	NN
cord-018834-4ligp4ak	287	8	)	)	-RRB-
cord-018834-4ligp4ak	287	9	is	be	VBZ
cord-018834-4ligp4ak	287	10	used	use	VBN
cord-018834-4ligp4ak	287	11	in	in	IN
cord-018834-4ligp4ak	287	12	patients	patient	NNS
cord-018834-4ligp4ak	287	13	with	with	IN
cord-018834-4ligp4ak	287	14	edema	edema	NN
cord-018834-4ligp4ak	287	15	as	as	IN
cord-018834-4ligp4ak	287	16	it	-PRON-	PRP
cord-018834-4ligp4ak	287	17	avoids	avoid	VBZ
cord-018834-4ligp4ak	287	18	excessive	excessive	JJ
cord-018834-4ligp4ak	287	19	sodium	sodium	NN
cord-018834-4ligp4ak	287	20	and	and	CC
cord-018834-4ligp4ak	287	21	chloride	chloride	NN
cord-018834-4ligp4ak	287	22	loads	load	NNS
cord-018834-4ligp4ak	287	23	[	[	-LRB-
cord-018834-4ligp4ak	287	24	75	75	CD
cord-018834-4ligp4ak	287	25	]	]	-RRB-
cord-018834-4ligp4ak	287	26	.	.	.
cord-018834-4ligp4ak	288	1	Nevertheless	nevertheless	RB
cord-018834-4ligp4ak	288	2	,	,	,
cord-018834-4ligp4ak	288	3	hypotonic	hypotonic	JJ
cord-018834-4ligp4ak	288	4	4	4	CD
cord-018834-4ligp4ak	288	5	%	%	NN
cord-018834-4ligp4ak	288	6	solutions	solution	NNS
cord-018834-4ligp4ak	288	7	should	should	MD
cord-018834-4ligp4ak	288	8	not	not	RB
cord-018834-4ligp4ak	288	9	be	be	VB
cord-018834-4ligp4ak	288	10	used	use	VBN
cord-018834-4ligp4ak	288	11	in	in	IN
cord-018834-4ligp4ak	288	12	patients	patient	NNS
cord-018834-4ligp4ak	288	13	with	with	IN
cord-018834-4ligp4ak	288	14	traumatic	traumatic	JJ
cord-018834-4ligp4ak	288	15	brain	brain	NN
cord-018834-4ligp4ak	288	16	injuries	injury	NNS
cord-018834-4ligp4ak	288	17	.	.	.
cord-018834-4ligp4ak	289	1	The	the	DT
cord-018834-4ligp4ak	289	2	excessive	excessive	JJ
cord-018834-4ligp4ak	289	3	need	need	NN
cord-018834-4ligp4ak	289	4	for	for	IN
cord-018834-4ligp4ak	289	5	the	the	DT
cord-018834-4ligp4ak	289	6	HSA	HSA	NNP
cord-018834-4ligp4ak	289	7	solutions	solution	NNS
cord-018834-4ligp4ak	289	8	has	have	VBZ
cord-018834-4ligp4ak	289	9	encouraged	encourage	VBN
cord-018834-4ligp4ak	289	10	its	-PRON-	PRP$
cord-018834-4ligp4ak	289	11	production	production	NN
cord-018834-4ligp4ak	289	12	using	use	VBG
cord-018834-4ligp4ak	289	13	recombinant	recombinant	JJ
cord-018834-4ligp4ak	289	14	DNA	dna	NN
cord-018834-4ligp4ak	289	15	technology	technology	NN
cord-018834-4ligp4ak	289	16	in	in	IN
cord-018834-4ligp4ak	289	17	both	both	DT
cord-018834-4ligp4ak	289	18	prokaryotic	prokaryotic	JJ
cord-018834-4ligp4ak	289	19	and	and	CC
cord-018834-4ligp4ak	289	20	eukaryotic	eukaryotic	JJ
cord-018834-4ligp4ak	289	21	hosts	host	NNS
cord-018834-4ligp4ak	289	22	.	.	.
cord-018834-4ligp4ak	290	1	HSA	HSA	NNP
cord-018834-4ligp4ak	290	2	molecule	molecule	NN
cord-018834-4ligp4ak	290	3	structure	structure	NN
cord-018834-4ligp4ak	290	4	is	be	VBZ
cord-018834-4ligp4ak	290	5	quite	quite	RB
cord-018834-4ligp4ak	290	6	complicated	complicated	JJ
cord-018834-4ligp4ak	290	7	;	;	:
cord-018834-4ligp4ak	290	8	with	with	IN
cord-018834-4ligp4ak	290	9	35	35	CD
cord-018834-4ligp4ak	290	10	cysteine	cysteine	NN
cord-018834-4ligp4ak	290	11	residues	residue	NNS
cord-018834-4ligp4ak	290	12	,	,	,
cord-018834-4ligp4ak	290	13	34	34	CD
cord-018834-4ligp4ak	290	14	of	of	IN
cord-018834-4ligp4ak	290	15	them	-PRON-	PRP
cord-018834-4ligp4ak	290	16	form	form	VBP
cord-018834-4ligp4ak	290	17	disulfi	disulfi	NNP
cord-018834-4ligp4ak	290	18	de	de	NNP
cord-018834-4ligp4ak	290	19	bonds	bond	NNS
cord-018834-4ligp4ak	290	20	.	.	.
cord-018834-4ligp4ak	291	1	Such	such	JJ
cord-018834-4ligp4ak	291	2	complicated	complicated	JJ
cord-018834-4ligp4ak	291	3	structure	structure	NN
cord-018834-4ligp4ak	291	4	in	in	IN
cord-018834-4ligp4ak	291	5	this	this	DT
cord-018834-4ligp4ak	291	6	large	large	JJ
cord-018834-4ligp4ak	291	7	recombinant	recombinant	JJ
cord-018834-4ligp4ak	291	8	protein	protein	NN
cord-018834-4ligp4ak	291	9	could	could	MD
cord-018834-4ligp4ak	291	10	be	be	VB
cord-018834-4ligp4ak	291	11	a	a	DT
cord-018834-4ligp4ak	291	12	burden	burden	NN
cord-018834-4ligp4ak	291	13	in	in	IN
cord-018834-4ligp4ak	291	14	both	both	DT
cord-018834-4ligp4ak	291	15	protein	protein	NN
cord-018834-4ligp4ak	291	16	synthesis	synthesis	NN
cord-018834-4ligp4ak	291	17	and	and	CC
cord-018834-4ligp4ak	291	18	folding	folding	NN
cord-018834-4ligp4ak	291	19	system	system	NN
cord-018834-4ligp4ak	291	20	,	,	,
cord-018834-4ligp4ak	291	21	which	which	WDT
cord-018834-4ligp4ak	291	22	could	could	MD
cord-018834-4ligp4ak	291	23	result	result	VB
cord-018834-4ligp4ak	291	24	in	in	IN
cord-018834-4ligp4ak	291	25	the	the	DT
cord-018834-4ligp4ak	291	26	low	low	JJ
cord-018834-4ligp4ak	291	27	expression	expression	NN
cord-018834-4ligp4ak	291	28	or	or	CC
cord-018834-4ligp4ak	291	29	incorrect	incorrect	JJ
cord-018834-4ligp4ak	291	30	folding	folding	NN
cord-018834-4ligp4ak	291	31	of	of	IN
cord-018834-4ligp4ak	291	32	recombinant	recombinant	JJ
cord-018834-4ligp4ak	291	33	HSA	HSA	NNP
cord-018834-4ligp4ak	291	34	(	(	-LRB-
cord-018834-4ligp4ak	291	35	rHSA	rhsa	NN
cord-018834-4ligp4ak	291	36	)	)	-RRB-
cord-018834-4ligp4ak	291	37	.	.	.
cord-018834-4ligp4ak	292	1	Recently	recently	RB
cord-018834-4ligp4ak	292	2	,	,	,
cord-018834-4ligp4ak	292	3	transgenic	transgenic	JJ
cord-018834-4ligp4ak	292	4	rice	rice	NN
cord-018834-4ligp4ak	292	5	Oryza	oryza	NN
cord-018834-4ligp4ak	292	6	sativa	sativa	NN
cord-018834-4ligp4ak	292	7	has	have	VBZ
cord-018834-4ligp4ak	292	8	been	be	VBN
cord-018834-4ligp4ak	292	9	used	use	VBN
cord-018834-4ligp4ak	292	10	successfully	successfully	RB
cord-018834-4ligp4ak	292	11	as	as	IN
cord-018834-4ligp4ak	292	12	a	a	DT
cord-018834-4ligp4ak	292	13	novel	novel	JJ
cord-018834-4ligp4ak	292	14	bioreactor	bioreactor	NN
cord-018834-4ligp4ak	292	15	to	to	TO
cord-018834-4ligp4ak	292	16	produce	produce	VB
cord-018834-4ligp4ak	292	17	suffi	suffi	NNP
cord-018834-4ligp4ak	292	18	cient	cient	JJ
cord-018834-4ligp4ak	292	19	quantities	quantity	NNS
cord-018834-4ligp4ak	292	20	of	of	IN
cord-018834-4ligp4ak	292	21	safe	safe	JJ
cord-018834-4ligp4ak	292	22	rHSA	rhsa	NN
cord-018834-4ligp4ak	292	23	.	.	.
cord-018834-4ligp4ak	293	1	However	however	RB
cord-018834-4ligp4ak	293	2	,	,	,
cord-018834-4ligp4ak	293	3	to	to	TO
cord-018834-4ligp4ak	293	4	establish	establish	VB
cord-018834-4ligp4ak	293	5	appropriate	appropriate	JJ
cord-018834-4ligp4ak	293	6	impurity	impurity	NN
cord-018834-4ligp4ak	293	7	removal	removal	NN
cord-018834-4ligp4ak	293	8	and	and	CC
cord-018834-4ligp4ak	293	9	detection	detection	NN
cord-018834-4ligp4ak	293	10	methods	method	NNS
cord-018834-4ligp4ak	293	11	in	in	IN
cord-018834-4ligp4ak	293	12	rHSA	rhsa	JJ
cord-018834-4ligp4ak	293	13	manufacturing	manufacturing	NN
cord-018834-4ligp4ak	293	14	remains	remain	VBZ
cord-018834-4ligp4ak	293	15	a	a	DT
cord-018834-4ligp4ak	293	16	challenge	challenge	NN
cord-018834-4ligp4ak	293	17	(	(	-LRB-
cord-018834-4ligp4ak	293	18	Fig	fig	NN
cord-018834-4ligp4ak	293	19	.	.	.
cord-018834-4ligp4ak	293	20	9.4	9.4	CD
cord-018834-4ligp4ak	293	21	)	)	-RRB-
cord-018834-4ligp4ak	294	1	[	[	-LRB-
cord-018834-4ligp4ak	294	2	79	79	CD
cord-018834-4ligp4ak	294	3	,	,	,
cord-018834-4ligp4ak	294	4	80	80	CD
cord-018834-4ligp4ak	294	5	]	]	-RRB-
cord-018834-4ligp4ak	294	6	.	.	.
cord-018834-4ligp4ak	295	1	HSA	HSA	NNP
cord-018834-4ligp4ak	295	2	has	have	VBZ
cord-018834-4ligp4ak	295	3	many	many	JJ
cord-018834-4ligp4ak	295	4	physiological	physiological	JJ
cord-018834-4ligp4ak	295	5	and	and	CC
cord-018834-4ligp4ak	295	6	biochemical	biochemical	JJ
cord-018834-4ligp4ak	295	7	properties	property	NNS
cord-018834-4ligp4ak	295	8	that	that	WDT
cord-018834-4ligp4ak	295	9	render	render	VBP
cord-018834-4ligp4ak	295	10	its	-PRON-	PRP$
cord-018834-4ligp4ak	295	11	use	use	NN
cord-018834-4ligp4ak	295	12	relevant	relevant	JJ
cord-018834-4ligp4ak	295	13	to	to	IN
cord-018834-4ligp4ak	295	14	many	many	JJ
cord-018834-4ligp4ak	295	15	aspects	aspect	NNS
cord-018834-4ligp4ak	295	16	of	of	IN
cord-018834-4ligp4ak	295	17	the	the	DT
cord-018834-4ligp4ak	295	18	disordered	disordered	JJ
cord-018834-4ligp4ak	295	19	vascular	vascular	JJ
cord-018834-4ligp4ak	295	20	and	and	CC
cord-018834-4ligp4ak	295	21	cellular	cellular	JJ
cord-018834-4ligp4ak	295	22	functions	function	NNS
cord-018834-4ligp4ak	295	23	.	.	.
cord-018834-4ligp4ak	296	1	HSA	HSA	NNP
cord-018834-4ligp4ak	296	2	has	have	VBZ
cord-018834-4ligp4ak	296	3	not	not	RB
cord-018834-4ligp4ak	296	4	yet	yet	RB
cord-018834-4ligp4ak	296	5	showed	show	VBN
cord-018834-4ligp4ak	296	6	all	all	PDT
cord-018834-4ligp4ak	296	7	its	-PRON-	PRP$
cord-018834-4ligp4ak	296	8	secrets	secret	NNS
cord-018834-4ligp4ak	296	9	,	,	,
cord-018834-4ligp4ak	296	10	and	and	CC
cord-018834-4ligp4ak	296	11	its	-PRON-	PRP$
cord-018834-4ligp4ak	296	12	benefi	benefi	JJ
cord-018834-4ligp4ak	296	13	ts	ts	NN
cord-018834-4ligp4ak	296	14	can	can	MD
cord-018834-4ligp4ak	296	15	only	only	RB
cord-018834-4ligp4ak	296	16	be	be	VB
cord-018834-4ligp4ak	296	17	realized	realize	VBN
cord-018834-4ligp4ak	296	18	by	by	IN
cord-018834-4ligp4ak	296	19	conducting	conduct	VBG
cord-018834-4ligp4ak	296	20	clinical	clinical	JJ
cord-018834-4ligp4ak	296	21	trials	trial	NNS
cord-018834-4ligp4ak	296	22	appropriately	appropriately	RB
cord-018834-4ligp4ak	296	23	powered	power	VBN
cord-018834-4ligp4ak	296	24	to	to	TO
cord-018834-4ligp4ak	296	25	relevant	relevant	JJ
cord-018834-4ligp4ak	296	26	clinical	clinical	JJ
cord-018834-4ligp4ak	296	27	endpoints	endpoint	NNS
cord-018834-4ligp4ak	296	28	.	.	.
cord-018834-4ligp4ak	296	29	 	 	_SP
cord-018834-4ligp4ak	297	1	The	the	DT
cord-018834-4ligp4ak	297	2	role	role	NN
cord-018834-4ligp4ak	297	3	of	of	IN
cord-018834-4ligp4ak	297	4	albumin	albumin	NN
cord-018834-4ligp4ak	297	5	as	as	IN
cord-018834-4ligp4ak	297	6	a	a	DT
cord-018834-4ligp4ak	297	7	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	297	8	fl	fl	NNP
cord-018834-4ligp4ak	297	9	uid	uid	NN
cord-018834-4ligp4ak	297	10	for	for	IN
cord-018834-4ligp4ak	297	11	patients	patient	NNS
cord-018834-4ligp4ak	297	12	with	with	IN
cord-018834-4ligp4ak	297	13	sepsis	sepsis	NN
cord-018834-4ligp4ak	297	14	:	:	:
cord-018834-4ligp4ak	297	15	a	a	DT
cord-018834-4ligp4ak	297	16	systematic	systematic	JJ
cord-018834-4ligp4ak	297	17	review	review	NN
cord-018834-4ligp4ak	297	18	and	and	CC
cord-018834-4ligp4ak	297	19	meta	meta	NNP
cord-018834-4ligp4ak	297	20	-	-	HYPH
cord-018834-4ligp4ak	297	21	analysis	analysis	NN
cord-018834-4ligp4ak	297	22	Biologically	biologically	RB
cord-018834-4ligp4ak	297	23	active	active	JJ
cord-018834-4ligp4ak	297	24	peptides	peptide	NNS
cord-018834-4ligp4ak	297	25	from	from	IN
cord-018834-4ligp4ak	297	26	bothrops	bothrops	NNP
cord-018834-4ligp4ak	297	27	jararacussu	jararacussu	NNP
cord-018834-4ligp4ak	297	28	venom	venom	NN
cord-018834-4ligp4ak	297	29	Albumin	albumin	NN
cord-018834-4ligp4ak	297	30	for	for	IN
cord-018834-4ligp4ak	297	31	bacterial	bacterial	JJ
cord-018834-4ligp4ak	297	32	infections	infection	NNS
cord-018834-4ligp4ak	297	33	other	other	JJ
cord-018834-4ligp4ak	297	34	than	than	IN
cord-018834-4ligp4ak	297	35	spontaneous	spontaneous	JJ
cord-018834-4ligp4ak	297	36	bacterial	bacterial	JJ
cord-018834-4ligp4ak	297	37	peritonitis	peritonitis	NN
cord-018834-4ligp4ak	297	38	in	in	IN
cord-018834-4ligp4ak	297	39	cirrhosis	cirrhosis	NN
cord-018834-4ligp4ak	297	40	.	.	.
cord-018834-4ligp4ak	298	1	A	a	DT
cord-018834-4ligp4ak	298	2	randomized	randomized	JJ
cord-018834-4ligp4ak	298	3	,	,	,
cord-018834-4ligp4ak	298	4	controlled	control	VBN
cord-018834-4ligp4ak	298	5	study	study	NN
cord-018834-4ligp4ak	299	1	The	the	DT
cord-018834-4ligp4ak	299	2	COASST	COASST	NNP
cord-018834-4ligp4ak	299	3	study	study	NN
cord-018834-4ligp4ak	299	4	:	:	:
cord-018834-4ligp4ak	299	5	cost	cost	NN
cord-018834-4ligp4ak	299	6	-	-	HYPH
cord-018834-4ligp4ak	299	7	effectiveness	effectiveness	NN
cord-018834-4ligp4ak	299	8	of	of	IN
cord-018834-4ligp4ak	299	9	albumin	albumin	NN
cord-018834-4ligp4ak	299	10	in	in	IN
cord-018834-4ligp4ak	299	11	severe	severe	JJ
cord-018834-4ligp4ak	299	12	sepsis	sepsis	NN
cord-018834-4ligp4ak	299	13	and	and	CC
cord-018834-4ligp4ak	299	14	septic	septic	JJ
cord-018834-4ligp4ak	299	15	shock	shock	NN
cord-018834-4ligp4ak	299	16	Albumin	albumin	NN
cord-018834-4ligp4ak	299	17	usage	usage	NN
cord-018834-4ligp4ak	299	18	in	in	IN
cord-018834-4ligp4ak	299	19	clinical	clinical	JJ
cord-018834-4ligp4ak	299	20	medicine	medicine	NN
cord-018834-4ligp4ak	299	21	:	:	:
cord-018834-4ligp4ak	299	22	tradition	tradition	NN
cord-018834-4ligp4ak	299	23	or	or	CC
cord-018834-4ligp4ak	299	24	therapeutic	therapeutic	JJ
cord-018834-4ligp4ak	299	25	Human	human	JJ
cord-018834-4ligp4ak	299	26	serum	serum	NN
cord-018834-4ligp4ak	299	27	albumin	albumin	NN
cord-018834-4ligp4ak	299	28	isoforms	isoform	NNS
cord-018834-4ligp4ak	299	29	:	:	:
cord-018834-4ligp4ak	299	30	genetic	genetic	JJ
cord-018834-4ligp4ak	299	31	and	and	CC
cord-018834-4ligp4ak	299	32	molecular	molecular	JJ
cord-018834-4ligp4ak	299	33	aspects	aspect	NNS
cord-018834-4ligp4ak	299	34	and	and	CC
cord-018834-4ligp4ak	299	35	functional	functional	JJ
cord-018834-4ligp4ak	299	36	consequences	consequence	NNS
cord-018834-4ligp4ak	300	1	Erythrocytes	erythrocyte	NNS
cord-018834-4ligp4ak	300	2	serve	serve	VBP
cord-018834-4ligp4ak	300	3	as	as	IN
cord-018834-4ligp4ak	300	4	a	a	DT
cord-018834-4ligp4ak	300	5	reservoir	reservoir	NN
cord-018834-4ligp4ak	300	6	for	for	IN
cord-018834-4ligp4ak	300	7	cellular	cellular	JJ
cord-018834-4ligp4ak	300	8	and	and	CC
cord-018834-4ligp4ak	300	9	extracellular	extracellular	JJ
cord-018834-4ligp4ak	300	10	sphingosine	sphingosine	NN
cord-018834-4ligp4ak	300	11	1-phosphate	1-phosphate	CD
cord-018834-4ligp4ak	301	1	The	the	DT
cord-018834-4ligp4ak	301	2	effects	effect	NNS
cord-018834-4ligp4ak	301	3	of	of	IN
cord-018834-4ligp4ak	301	4	native	native	JJ
cord-018834-4ligp4ak	301	5	and	and	CC
cord-018834-4ligp4ak	301	6	modifi	modifi	JJ
cord-018834-4ligp4ak	301	7	ed	ed	NN
cord-018834-4ligp4ak	301	8	bovine	bovine	JJ
cord-018834-4ligp4ak	301	9	serum	serum	NN
cord-018834-4ligp4ak	301	10	albumin	albumin	NN
cord-018834-4ligp4ak	301	11	on	on	IN
cord-018834-4ligp4ak	301	12	the	the	DT
cord-018834-4ligp4ak	301	13	permeability	permeability	NN
cord-018834-4ligp4ak	301	14	of	of	IN
cord-018834-4ligp4ak	301	15	frog	frog	NN
cord-018834-4ligp4ak	301	16	mesenteric	mesenteric	JJ
cord-018834-4ligp4ak	301	17	capillaries	capillary	NNS
cord-018834-4ligp4ak	301	18	Sphingosine	Sphingosine	NNP
cord-018834-4ligp4ak	301	19	1-phosphate	1-phosphate	CD
cord-018834-4ligp4ak	301	20	in	in	IN
cord-018834-4ligp4ak	301	21	blood	blood	NN
cord-018834-4ligp4ak	301	22	:	:	:
cord-018834-4ligp4ak	301	23	function	function	NN
cord-018834-4ligp4ak	301	24	,	,	,
cord-018834-4ligp4ak	301	25	metabolism	metabolism	NN
cord-018834-4ligp4ak	301	26	,	,	,
cord-018834-4ligp4ak	301	27	and	and	CC
cord-018834-4ligp4ak	301	28	fate	fate	NN
cord-018834-4ligp4ak	301	29	Sphingosine-1-phosphate	sphingosine-1-phosphate	RB
cord-018834-4ligp4ak	302	1	protects	protect	VBZ
cord-018834-4ligp4ak	302	2	endothelial	endothelial	JJ
cord-018834-4ligp4ak	302	3	glycocalyx	glycocalyx	NN
cord-018834-4ligp4ak	302	4	by	by	IN
cord-018834-4ligp4ak	302	5	inhibiting	inhibit	VBG
cord-018834-4ligp4ak	302	6	syndecan-1	syndecan-1	NNP
cord-018834-4ligp4ak	302	7	shedding	shed	VBG
cord-018834-4ligp4ak	302	8	Measuring	measure	VBG
cord-018834-4ligp4ak	302	9	reactive	reactive	JJ
cord-018834-4ligp4ak	302	10	species	specie	NNS
cord-018834-4ligp4ak	302	11	and	and	CC
cord-018834-4ligp4ak	302	12	oxidative	oxidative	JJ
cord-018834-4ligp4ak	302	13	damage	damage	NN
cord-018834-4ligp4ak	302	14	in	in	IN
cord-018834-4ligp4ak	302	15	vivo	vivo	NN
cord-018834-4ligp4ak	302	16	and	and	CC
cord-018834-4ligp4ak	302	17	in	in	IN
cord-018834-4ligp4ak	302	18	cell	cell	NN
cord-018834-4ligp4ak	302	19	culture	culture	NN
cord-018834-4ligp4ak	303	1	:	:	:
cord-018834-4ligp4ak	303	2	how	how	WRB
cord-018834-4ligp4ak	303	3	should	should	MD
cord-018834-4ligp4ak	303	4	you	-PRON-	PRP
cord-018834-4ligp4ak	303	5	do	do	VB
cord-018834-4ligp4ak	303	6	it	-PRON-	PRP
cord-018834-4ligp4ak	303	7	and	and	CC
cord-018834-4ligp4ak	303	8	what	what	WP
cord-018834-4ligp4ak	303	9	do	do	VBP
cord-018834-4ligp4ak	303	10	the	the	DT
cord-018834-4ligp4ak	303	11	results	result	NNS
cord-018834-4ligp4ak	303	12	mean	mean	VB
cord-018834-4ligp4ak	303	13	?	?	.
cord-018834-4ligp4ak	304	1	Human	human	JJ
cord-018834-4ligp4ak	304	2	serum	serum	NN
cord-018834-4ligp4ak	304	3	albumin	albumin	NN
cord-018834-4ligp4ak	304	4	and	and	CC
cord-018834-4ligp4ak	304	5	its	-PRON-	PRP$
cord-018834-4ligp4ak	304	6	n	n	JJ
cord-018834-4ligp4ak	304	7	-	-	HYPH
cord-018834-4ligp4ak	304	8	terminal	terminal	NN
cord-018834-4ligp4ak	304	9	tetrapeptide	tetrapeptide	NN
cord-018834-4ligp4ak	304	10	(	(	-LRB-
cord-018834-4ligp4ak	304	11	dahk	dahk	NNP
cord-018834-4ligp4ak	304	12	)	)	-RRB-
cord-018834-4ligp4ak	304	13	block	block	NN
cord-018834-4ligp4ak	304	14	oxidant	oxidant	NN
cord-018834-4ligp4ak	304	15	-	-	HYPH
cord-018834-4ligp4ak	304	16	induced	induce	VBN
cord-018834-4ligp4ak	304	17	neuronal	neuronal	JJ
cord-018834-4ligp4ak	304	18	death	death	NN
cord-018834-4ligp4ak	304	19	Human	Human	NNP
cord-018834-4ligp4ak	304	20	serum	serum	NN
cord-018834-4ligp4ak	304	21	albumin	albumin	NN
cord-018834-4ligp4ak	304	22	:	:	:
cord-018834-4ligp4ak	304	23	from	from	IN
cord-018834-4ligp4ak	304	24	bench	bench	NN
cord-018834-4ligp4ak	304	25	to	to	IN
cord-018834-4ligp4ak	304	26	bedside	bedside	NN
cord-018834-4ligp4ak	305	1	The	the	DT
cord-018834-4ligp4ak	305	2	antioxidant	antioxidant	JJ
cord-018834-4ligp4ak	305	3	properties	property	NNS
cord-018834-4ligp4ak	305	4	of	of	IN
cord-018834-4ligp4ak	305	5	serum	serum	NN
cord-018834-4ligp4ak	305	6	albumin	albumin	NN
cord-018834-4ligp4ak	305	7	Free	free	JJ
cord-018834-4ligp4ak	305	8	and	and	CC
cord-018834-4ligp4ak	305	9	albumin	albumin	NN
cord-018834-4ligp4ak	305	10	-	-	HYPH
cord-018834-4ligp4ak	305	11	bound	bind	VBN
cord-018834-4ligp4ak	305	12	bilirubin	bilirubin	NN
cord-018834-4ligp4ak	305	13	are	be	VBP
cord-018834-4ligp4ak	305	14	effi	effi	NNP
cord-018834-4ligp4ak	305	15	cient	cient	NNP
cord-018834-4ligp4ak	305	16	co	co	NNS
cord-018834-4ligp4ak	305	17	-	-	NNS
cord-018834-4ligp4ak	305	18	antioxidants	antioxidant	NNS
cord-018834-4ligp4ak	305	19	for	for	IN
cord-018834-4ligp4ak	305	20	alphatocopherol	alphatocopherol	NNP
cord-018834-4ligp4ak	305	21	,	,	,
cord-018834-4ligp4ak	305	22	inhibiting	inhibit	VBG
cord-018834-4ligp4ak	305	23	plasma	plasma	NN
cord-018834-4ligp4ak	305	24	and	and	CC
cord-018834-4ligp4ak	305	25	low	low	JJ
cord-018834-4ligp4ak	305	26	density	density	NN
cord-018834-4ligp4ak	305	27	lipoprotein	lipoprotein	NN
cord-018834-4ligp4ak	305	28	lipid	lipid	NN
cord-018834-4ligp4ak	305	29	peroxidation	peroxidation	NN
cord-018834-4ligp4ak	305	30	Albumin	albumin	NN
cord-018834-4ligp4ak	305	31	-	-	HYPH
cord-018834-4ligp4ak	305	32	bound	bind	VBN
cord-018834-4ligp4ak	305	33	bilirubins	bilirubin	NNS
cord-018834-4ligp4ak	305	34	protect	protect	VBP
cord-018834-4ligp4ak	305	35	human	human	JJ
cord-018834-4ligp4ak	305	36	ventricular	ventricular	JJ
cord-018834-4ligp4ak	305	37	myocytes	myocyte	NNS
cord-018834-4ligp4ak	305	38	against	against	IN
cord-018834-4ligp4ak	305	39	oxyradical	oxyradical	JJ
cord-018834-4ligp4ak	305	40	damage	damage	NN
cord-018834-4ligp4ak	305	41	Vascular	Vascular	NNP
cord-018834-4ligp4ak	305	42	oxidant	oxidant	JJ
cord-018834-4ligp4ak	305	43	stress	stress	NN
cord-018834-4ligp4ak	305	44	and	and	CC
cord-018834-4ligp4ak	305	45	infl	infl	NNP
cord-018834-4ligp4ak	305	46	ammation	ammation	NNP
cord-018834-4ligp4ak	305	47	in	in	IN
cord-018834-4ligp4ak	305	48	hyperhomocysteinemia	hyperhomocysteinemia	NNP
cord-018834-4ligp4ak	305	49	Albumin	Albumin	NNP
cord-018834-4ligp4ak	305	50	:	:	:
cord-018834-4ligp4ak	306	1	biochemical	biochemical	JJ
cord-018834-4ligp4ak	306	2	properties	property	NNS
cord-018834-4ligp4ak	306	3	and	and	CC
cord-018834-4ligp4ak	306	4	therapeutic	therapeutic	JJ
cord-018834-4ligp4ak	306	5	potential	potential	JJ
cord-018834-4ligp4ak	306	6	S	s	NN
cord-018834-4ligp4ak	306	7	-	-	HYPH
cord-018834-4ligp4ak	306	8	nitroso	nitroso	NN
cord-018834-4ligp4ak	306	9	-	-	HYPH
cord-018834-4ligp4ak	306	10	albumin	albumin	NN
cord-018834-4ligp4ak	306	11	carries	carry	VBZ
cord-018834-4ligp4ak	306	12	a	a	DT
cord-018834-4ligp4ak	306	13	thiol	thiol	NN
cord-018834-4ligp4ak	306	14	-	-	HYPH
cord-018834-4ligp4ak	306	15	labile	labile	JJ
cord-018834-4ligp4ak	306	16	pool	pool	NN
cord-018834-4ligp4ak	306	17	of	of	IN
cord-018834-4ligp4ak	306	18	nitric	nitric	NN
cord-018834-4ligp4ak	306	19	oxide	oxide	NN
cord-018834-4ligp4ak	306	20	,	,	,
cord-018834-4ligp4ak	306	21	which	which	WDT
cord-018834-4ligp4ak	306	22	causes	cause	VBZ
cord-018834-4ligp4ak	306	23	venodilation	venodilation	NN
cord-018834-4ligp4ak	306	24	in	in	IN
cord-018834-4ligp4ak	306	25	the	the	DT
cord-018834-4ligp4ak	306	26	rat	rat	NN
cord-018834-4ligp4ak	306	27	Nitric	Nitric	NNP
cord-018834-4ligp4ak	306	28	oxide	oxide	NN
cord-018834-4ligp4ak	306	29	and	and	CC
cord-018834-4ligp4ak	306	30	peroxynitrite	peroxynitrite	NN
cord-018834-4ligp4ak	306	31	in	in	IN
cord-018834-4ligp4ak	306	32	health	health	NN
cord-018834-4ligp4ak	306	33	and	and	CC
cord-018834-4ligp4ak	306	34	disease	disease	NNP
cord-018834-4ligp4ak	306	35	Administration	Administration	NNP
cord-018834-4ligp4ak	306	36	of	of	IN
cord-018834-4ligp4ak	306	37	albumin	albumin	NN
cord-018834-4ligp4ak	306	38	to	to	IN
cord-018834-4ligp4ak	306	39	patients	patient	NNS
cord-018834-4ligp4ak	306	40	with	with	IN
cord-018834-4ligp4ak	306	41	sepsis	sepsis	NN
cord-018834-4ligp4ak	306	42	syndrome	syndrome	NN
cord-018834-4ligp4ak	306	43	:	:	:
cord-018834-4ligp4ak	306	44	a	a	DT
cord-018834-4ligp4ak	306	45	possible	possible	JJ
cord-018834-4ligp4ak	306	46	benefi	benefi	JJ
cord-018834-4ligp4ak	306	47	cial	cial	JJ
cord-018834-4ligp4ak	306	48	role	role	NN
cord-018834-4ligp4ak	306	49	in	in	IN
cord-018834-4ligp4ak	306	50	plasma	plasma	NN
cord-018834-4ligp4ak	306	51	thiol	thiol	NN
cord-018834-4ligp4ak	306	52	repletion	repletion	NN
cord-018834-4ligp4ak	306	53	Albumin	Albumin	NNP
cord-018834-4ligp4ak	306	54	infl	infl	XX
cord-018834-4ligp4ak	306	55	uences	uences	NNP
cord-018834-4ligp4ak	306	56	total	total	JJ
cord-018834-4ligp4ak	306	57	plasma	plasma	NN
cord-018834-4ligp4ak	306	58	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	306	59	capacity	capacity	NN
cord-018834-4ligp4ak	306	60	favorably	favorably	RB
cord-018834-4ligp4ak	306	61	in	in	IN
cord-018834-4ligp4ak	306	62	patients	patient	NNS
cord-018834-4ligp4ak	306	63	with	with	IN
cord-018834-4ligp4ak	306	64	acute	acute	JJ
cord-018834-4ligp4ak	306	65	lung	lung	NN
cord-018834-4ligp4ak	306	66	injury	injury	NN
cord-018834-4ligp4ak	306	67	Albumin	albumin	NN
cord-018834-4ligp4ak	306	68	-an	-an	:
cord-018834-4ligp4ak	306	69	important	important	JJ
cord-018834-4ligp4ak	306	70	extracellular	extracellular	JJ
cord-018834-4ligp4ak	306	71	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	306	72	?	?	.
cord-018834-4ligp4ak	307	1	West	West	NNP
cord-018834-4ligp4ak	307	2	Nile	Nile	NNP
cord-018834-4ligp4ak	307	3	virus	virus	NN
cord-018834-4ligp4ak	307	4	is	be	VBZ
cord-018834-4ligp4ak	307	5	neutralized	neutralize	VBN
cord-018834-4ligp4ak	307	6	by	by	IN
cord-018834-4ligp4ak	307	7	HOClmodifi	HOClmodifi	NNP
cord-018834-4ligp4ak	307	8	ed	ed	NNP
cord-018834-4ligp4ak	307	9	human	human	JJ
cord-018834-4ligp4ak	307	10	serum	serum	NN
cord-018834-4ligp4ak	307	11	albumin	albumin	NN
cord-018834-4ligp4ak	307	12	that	that	WDT
cord-018834-4ligp4ak	307	13	binds	bind	VBZ
cord-018834-4ligp4ak	307	14	to	to	IN
cord-018834-4ligp4ak	307	15	domain	domain	NN
cord-018834-4ligp4ak	307	16	iii	iii	NN
cord-018834-4ligp4ak	307	17	of	of	IN
cord-018834-4ligp4ak	307	18	the	the	DT
cord-018834-4ligp4ak	307	19	viral	viral	JJ
cord-018834-4ligp4ak	307	20	envelope	envelope	NN
cord-018834-4ligp4ak	307	21	protein	protein	NN
cord-018834-4ligp4ak	307	22	E	E	NNP
cord-018834-4ligp4ak	307	23	Glycation	Glycation	NNP
cord-018834-4ligp4ak	307	24	of	of	IN
cord-018834-4ligp4ak	307	25	human	human	JJ
cord-018834-4ligp4ak	307	26	serum	serum	NN
cord-018834-4ligp4ak	307	27	albumin	albumin	NN
cord-018834-4ligp4ak	307	28	:	:	:
cord-018834-4ligp4ak	307	29	inhibition	inhibition	NN
cord-018834-4ligp4ak	307	30	by	by	IN
cord-018834-4ligp4ak	307	31	diclofenac	diclofenac	JJ
cord-018834-4ligp4ak	307	32	Hypochlorous	Hypochlorous	NNP
cord-018834-4ligp4ak	307	33	acid	acid	NN
cord-018834-4ligp4ak	307	34	generates	generate	VBZ
cord-018834-4ligp4ak	307	35	n	n	CD
cord-018834-4ligp4ak	307	36	epsilon-(carboxymethyl)lysine	epsilon-(carboxymethyl)lysine	NN
cord-018834-4ligp4ak	307	37	from	from	IN
cord-018834-4ligp4ak	307	38	amadori	amadori	NNP
cord-018834-4ligp4ak	307	39	products	product	NNS
cord-018834-4ligp4ak	307	40	Impairment	impairment	NN
cord-018834-4ligp4ak	307	41	of	of	IN
cord-018834-4ligp4ak	307	42	vascular	vascular	JJ
cord-018834-4ligp4ak	307	43	endothelial	endothelial	JJ
cord-018834-4ligp4ak	307	44	nitric	nitric	NN
cord-018834-4ligp4ak	307	45	oxide	oxide	NN
cord-018834-4ligp4ak	307	46	synthase	synthase	NN
cord-018834-4ligp4ak	307	47	activity	activity	NN
cord-018834-4ligp4ak	307	48	by	by	IN
cord-018834-4ligp4ak	307	49	advanced	advanced	JJ
cord-018834-4ligp4ak	307	50	glycation	glycation	NN
cord-018834-4ligp4ak	307	51	end	end	NN
cord-018834-4ligp4ak	307	52	products	product	NNS
cord-018834-4ligp4ak	308	1	Albumin	albumin	NN
cord-018834-4ligp4ak	308	2	competitively	competitively	RB
cord-018834-4ligp4ak	308	3	inhibits	inhibit	VBZ
cord-018834-4ligp4ak	308	4	glycation	glycation	NN
cord-018834-4ligp4ak	308	5	of	of	IN
cord-018834-4ligp4ak	308	6	less	less	RBR
cord-018834-4ligp4ak	308	7	abundant	abundant	JJ
cord-018834-4ligp4ak	308	8	proteins	protein	NNS
cord-018834-4ligp4ak	308	9	Impairment	Impairment	NNP
cord-018834-4ligp4ak	308	10	of	of	IN
cord-018834-4ligp4ak	308	11	serum	serum	NN
cord-018834-4ligp4ak	308	12	albumin	albumin	NN
cord-018834-4ligp4ak	308	13	antioxidant	antioxidant	NN
cord-018834-4ligp4ak	308	14	properties	property	NNS
cord-018834-4ligp4ak	308	15	in	in	IN
cord-018834-4ligp4ak	308	16	obstructive	obstructive	JJ
cord-018834-4ligp4ak	308	17	sleep	sleep	NN
cord-018834-4ligp4ak	308	18	apnoea	apnoea	NNP
cord-018834-4ligp4ak	308	19	syndrome	syndrome	NN
cord-018834-4ligp4ak	308	20	Review	Review	NNP
cord-018834-4ligp4ak	308	21	article	article	NN
cord-018834-4ligp4ak	308	22	:	:	:
cord-018834-4ligp4ak	308	23	albumin	albumin	NN
cord-018834-4ligp4ak	308	24	as	as	IN
cord-018834-4ligp4ak	308	25	a	a	DT
cord-018834-4ligp4ak	308	26	drug	drug	NN
cord-018834-4ligp4ak	308	27	--	--	:
cord-018834-4ligp4ak	308	28	biological	biological	JJ
cord-018834-4ligp4ak	308	29	effects	effect	NNS
cord-018834-4ligp4ak	308	30	of	of	IN
cord-018834-4ligp4ak	308	31	albumin	albumin	NN
cord-018834-4ligp4ak	308	32	unrelated	unrelated	JJ
cord-018834-4ligp4ak	308	33	to	to	IN
cord-018834-4ligp4ak	308	34	oncotic	oncotic	JJ
cord-018834-4ligp4ak	308	35	pressure	pressure	NN
cord-018834-4ligp4ak	308	36	Serum	serum	NN
cord-018834-4ligp4ak	308	37	albumin	albumin	NN
cord-018834-4ligp4ak	308	38	level	level	NN
cord-018834-4ligp4ak	308	39	as	as	IN
cord-018834-4ligp4ak	308	40	a	a	DT
cord-018834-4ligp4ak	308	41	risk	risk	NN
cord-018834-4ligp4ak	308	42	factor	factor	NN
cord-018834-4ligp4ak	308	43	for	for	IN
cord-018834-4ligp4ak	308	44	mortality	mortality	NN
cord-018834-4ligp4ak	308	45	in	in	IN
cord-018834-4ligp4ak	308	46	burn	burn	NN
cord-018834-4ligp4ak	308	47	patients	patient	NNS
cord-018834-4ligp4ak	308	48	Risk	risk	NN
cord-018834-4ligp4ak	308	49	factors	factor	NNS
cord-018834-4ligp4ak	308	50	and	and	CC
cord-018834-4ligp4ak	308	51	prognosis	prognosis	NN
cord-018834-4ligp4ak	308	52	of	of	IN
cord-018834-4ligp4ak	308	53	hypoalbuminemia	hypoalbuminemia	NN
cord-018834-4ligp4ak	308	54	in	in	IN
cord-018834-4ligp4ak	308	55	surgical	surgical	JJ
cord-018834-4ligp4ak	308	56	septic	septic	JJ
cord-018834-4ligp4ak	308	57	patients	patient	NNS
cord-018834-4ligp4ak	308	58	Hypoalbuminemia	Hypoalbuminemia	NNP
cord-018834-4ligp4ak	308	59	in	in	IN
cord-018834-4ligp4ak	308	60	acute	acute	JJ
cord-018834-4ligp4ak	308	61	illness	illness	NN
cord-018834-4ligp4ak	308	62	:	:	:
cord-018834-4ligp4ak	308	63	is	be	VBZ
cord-018834-4ligp4ak	308	64	there	there	EX
cord-018834-4ligp4ak	308	65	a	a	DT
cord-018834-4ligp4ak	308	66	rationale	rationale	NN
cord-018834-4ligp4ak	308	67	for	for	IN
cord-018834-4ligp4ak	308	68	intervention	intervention	NN
cord-018834-4ligp4ak	308	69	?	?	.
cord-018834-4ligp4ak	309	1	A	a	DT
cord-018834-4ligp4ak	309	2	meta	meta	JJ
cord-018834-4ligp4ak	309	3	-	-	HYPH
cord-018834-4ligp4ak	309	4	analysis	analysis	NN
cord-018834-4ligp4ak	309	5	of	of	IN
cord-018834-4ligp4ak	309	6	cohort	cohort	NN
cord-018834-4ligp4ak	309	7	studies	study	NNS
cord-018834-4ligp4ak	309	8	and	and	CC
cord-018834-4ligp4ak	309	9	controlled	control	VBN
cord-018834-4ligp4ak	309	10	trials	trial	NNS
cord-018834-4ligp4ak	309	11	Preoperative	Preoperative	NNP
cord-018834-4ligp4ak	309	12	hypoalbuminemia	hypoalbuminemia	NN
cord-018834-4ligp4ak	309	13	is	be	VBZ
cord-018834-4ligp4ak	309	14	a	a	DT
cord-018834-4ligp4ak	309	15	major	major	JJ
cord-018834-4ligp4ak	309	16	risk	risk	NN
cord-018834-4ligp4ak	309	17	factor	factor	NN
cord-018834-4ligp4ak	309	18	for	for	IN
cord-018834-4ligp4ak	309	19	acute	acute	JJ
cord-018834-4ligp4ak	309	20	kidney	kidney	NN
cord-018834-4ligp4ak	309	21	injury	injury	NN
cord-018834-4ligp4ak	309	22	following	follow	VBG
cord-018834-4ligp4ak	309	23	off	off	IN
cord-018834-4ligp4ak	309	24	-	-	HYPH
cord-018834-4ligp4ak	309	25	pump	pump	NN
cord-018834-4ligp4ak	309	26	coronary	coronary	JJ
cord-018834-4ligp4ak	309	27	artery	artery	NN
cord-018834-4ligp4ak	309	28	bypass	bypass	NN
cord-018834-4ligp4ak	309	29	surgery	surgery	NN
cord-018834-4ligp4ak	309	30	Extending	extend	VBG
cord-018834-4ligp4ak	309	31	half	half	JJ
cord-018834-4ligp4ak	309	32	-	-	HYPH
cord-018834-4ligp4ak	309	33	life	life	NN
cord-018834-4ligp4ak	309	34	by	by	IN
cord-018834-4ligp4ak	309	35	indirect	indirect	JJ
cord-018834-4ligp4ak	309	36	targeting	targeting	NN
cord-018834-4ligp4ak	309	37	of	of	IN
cord-018834-4ligp4ak	309	38	the	the	DT
cord-018834-4ligp4ak	309	39	neonatal	neonatal	JJ
cord-018834-4ligp4ak	309	40	fc	fc	NNP
cord-018834-4ligp4ak	309	41	receptor	receptor	NN
cord-018834-4ligp4ak	309	42	(	(	-LRB-
cord-018834-4ligp4ak	309	43	FcRn	FcRn	NNP
cord-018834-4ligp4ak	309	44	)	)	-RRB-
cord-018834-4ligp4ak	309	45	using	use	VBG
cord-018834-4ligp4ak	309	46	a	a	DT
cord-018834-4ligp4ak	309	47	minimal	minimal	JJ
cord-018834-4ligp4ak	309	48	albumin	albumin	NN
cord-018834-4ligp4ak	309	49	binding	bind	VBG
cord-018834-4ligp4ak	309	50	domain	domain	NN
cord-018834-4ligp4ak	309	51	Kinetics	Kinetics	NNP
cord-018834-4ligp4ak	309	52	of	of	IN
cord-018834-4ligp4ak	309	53	FcRn	FcRn	NNP
cord-018834-4ligp4ak	309	54	-	-	HYPH
cord-018834-4ligp4ak	309	55	mediated	mediate	VBN
cord-018834-4ligp4ak	309	56	recycling	recycling	NN
cord-018834-4ligp4ak	309	57	of	of	IN
cord-018834-4ligp4ak	309	58	IgG	igg	NN
cord-018834-4ligp4ak	309	59	and	and	CC
cord-018834-4ligp4ak	309	60	albumin	albumin	NN
cord-018834-4ligp4ak	309	61	in	in	IN
cord-018834-4ligp4ak	309	62	human	human	NN
cord-018834-4ligp4ak	309	63	:	:	:
cord-018834-4ligp4ak	309	64	pathophysiology	pathophysiology	NN
cord-018834-4ligp4ak	309	65	and	and	CC
cord-018834-4ligp4ak	309	66	therapeutic	therapeutic	JJ
cord-018834-4ligp4ak	309	67	implications	implication	NNS
cord-018834-4ligp4ak	309	68	using	use	VBG
cord-018834-4ligp4ak	309	69	a	a	DT
cord-018834-4ligp4ak	309	70	simplifi	simplifi	NNP
cord-018834-4ligp4ak	309	71	ed	ed	NN
cord-018834-4ligp4ak	309	72	mechanism	mechanism	NN
cord-018834-4ligp4ak	309	73	-	-	HYPH
cord-018834-4ligp4ak	309	74	based	base	VBN
cord-018834-4ligp4ak	309	75	model	model	NN
cord-018834-4ligp4ak	309	76	The	the	DT
cord-018834-4ligp4ak	309	77	multiple	multiple	JJ
cord-018834-4ligp4ak	309	78	facets	facet	NNS
cord-018834-4ligp4ak	309	79	of	of	IN
cord-018834-4ligp4ak	309	80	FcRn	FcRn	NNP
cord-018834-4ligp4ak	309	81	in	in	IN
cord-018834-4ligp4ak	309	82	immunity	immunity	NN
cord-018834-4ligp4ak	309	83	Human	Human	NNP
cord-018834-4ligp4ak	309	84	albumin	albumin	NN
cord-018834-4ligp4ak	309	85	administration	administration	NN
cord-018834-4ligp4ak	309	86	in	in	IN
cord-018834-4ligp4ak	309	87	critically	critically	RB
cord-018834-4ligp4ak	309	88	ill	ill	JJ
cord-018834-4ligp4ak	309	89	patients	patient	NNS
cord-018834-4ligp4ak	310	1	:	:	:
cord-018834-4ligp4ak	310	2	systematic	systematic	JJ
cord-018834-4ligp4ak	310	3	review	review	NN
cord-018834-4ligp4ak	310	4	of	of	IN
cord-018834-4ligp4ak	310	5	randomised	randomised	JJ
cord-018834-4ligp4ak	310	6	controlled	control	VBN
cord-018834-4ligp4ak	310	7	trials	trial	NNS
cord-018834-4ligp4ak	310	8	Beautiful	beautiful	JJ
cord-018834-4ligp4ak	310	9	small	small	JJ
cord-018834-4ligp4ak	310	10	:	:	:
cord-018834-4ligp4ak	310	11	misleading	mislead	VBG
cord-018834-4ligp4ak	310	12	large	large	JJ
cord-018834-4ligp4ak	310	13	randomized	randomize	VBN
cord-018834-4ligp4ak	310	14	controlled	control	VBN
cord-018834-4ligp4ak	310	15	trials	trial	NNS
cord-018834-4ligp4ak	310	16	?	?	.
cord-018834-4ligp4ak	311	1	The	the	DT
cord-018834-4ligp4ak	311	2	example	example	NN
cord-018834-4ligp4ak	311	3	of	of	IN
cord-018834-4ligp4ak	311	4	colloids	colloid	NNS
cord-018834-4ligp4ak	311	5	for	for	IN
cord-018834-4ligp4ak	311	6	volume	volume	NN
cord-018834-4ligp4ak	311	7	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	311	8	Patient	Patient	NNP
cord-018834-4ligp4ak	311	9	survival	survival	NN
cord-018834-4ligp4ak	311	10	after	after	IN
cord-018834-4ligp4ak	311	11	human	human	JJ
cord-018834-4ligp4ak	311	12	albumin	albumin	NNP
cord-018834-4ligp4ak	311	13	administration	administration	NNP
cord-018834-4ligp4ak	311	14	.	.	.
cord-018834-4ligp4ak	312	1	A	a	DT
cord-018834-4ligp4ak	312	2	metaanalysis	metaanalysis	NN
cord-018834-4ligp4ak	312	3	of	of	IN
cord-018834-4ligp4ak	312	4	randomized	randomized	JJ
cord-018834-4ligp4ak	312	5	,	,	,
cord-018834-4ligp4ak	312	6	controlled	control	VBN
cord-018834-4ligp4ak	312	7	trials	trial	NNS
cord-018834-4ligp4ak	312	8	Fluid	Fluid	NNP
cord-018834-4ligp4ak	312	9	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	312	10	of	of	IN
cord-018834-4ligp4ak	312	11	burn	burn	NN
cord-018834-4ligp4ak	312	12	patients	patient	NNS
cord-018834-4ligp4ak	312	13	comparing	compare	VBG
cord-018834-4ligp4ak	312	14	a	a	DT
cord-018834-4ligp4ak	312	15	crystalloid	crystalloid	NN
cord-018834-4ligp4ak	312	16	with	with	IN
cord-018834-4ligp4ak	312	17	a	a	DT
cord-018834-4ligp4ak	312	18	colloid	colloid	NN
cord-018834-4ligp4ak	312	19	containing	contain	VBG
cord-018834-4ligp4ak	312	20	solution	solution	NN
cord-018834-4ligp4ak	312	21	:	:	:
cord-018834-4ligp4ak	312	22	a	a	DT
cord-018834-4ligp4ak	312	23	prospective	prospective	JJ
cord-018834-4ligp4ak	312	24	study	study	NN
cord-018834-4ligp4ak	312	25	A	a	DT
cord-018834-4ligp4ak	312	26	comparison	comparison	NN
cord-018834-4ligp4ak	312	27	of	of	IN
cord-018834-4ligp4ak	312	28	albumin	albumin	NN
cord-018834-4ligp4ak	312	29	and	and	CC
cord-018834-4ligp4ak	312	30	saline	saline	NN
cord-018834-4ligp4ak	312	31	for	for	IN
cord-018834-4ligp4ak	312	32	fl	fl	NNP
cord-018834-4ligp4ak	312	33	uid	uid	NN
cord-018834-4ligp4ak	312	34	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	312	35	in	in	IN
cord-018834-4ligp4ak	312	36	the	the	DT
cord-018834-4ligp4ak	312	37	intensive	intensive	JJ
cord-018834-4ligp4ak	312	38	care	care	NN
cord-018834-4ligp4ak	312	39	unit	unit	NN
cord-018834-4ligp4ak	312	40	Albumin	albumin	NN
cord-018834-4ligp4ak	312	41	replacement	replacement	NN
cord-018834-4ligp4ak	312	42	in	in	IN
cord-018834-4ligp4ak	312	43	patients	patient	NNS
cord-018834-4ligp4ak	312	44	with	with	IN
cord-018834-4ligp4ak	312	45	severe	severe	JJ
cord-018834-4ligp4ak	312	46	sepsis	sepsis	NN
cord-018834-4ligp4ak	312	47	or	or	CC
cord-018834-4ligp4ak	312	48	septic	septic	JJ
cord-018834-4ligp4ak	312	49	shock	shock	NN
cord-018834-4ligp4ak	312	50	Fluid	Fluid	NNP
cord-018834-4ligp4ak	312	51	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	312	52	in	in	IN
cord-018834-4ligp4ak	312	53	sepsis	sepsis	NN
cord-018834-4ligp4ak	312	54	:	:	:
cord-018834-4ligp4ak	312	55	a	a	DT
cord-018834-4ligp4ak	312	56	systematic	systematic	JJ
cord-018834-4ligp4ak	312	57	review	review	NN
cord-018834-4ligp4ak	312	58	and	and	CC
cord-018834-4ligp4ak	312	59	network	network	NN
cord-018834-4ligp4ak	312	60	meta	meta	NNP
cord-018834-4ligp4ak	312	61	-	-	HYPH
cord-018834-4ligp4ak	312	62	analysis	analysis	NN
cord-018834-4ligp4ak	312	63	Comparison	comparison	NN
cord-018834-4ligp4ak	312	64	of	of	IN
cord-018834-4ligp4ak	312	65	the	the	DT
cord-018834-4ligp4ak	312	66	effects	effect	NNS
cord-018834-4ligp4ak	312	67	of	of	IN
cord-018834-4ligp4ak	312	68	albumin	albumin	NN
cord-018834-4ligp4ak	312	69	and	and	CC
cord-018834-4ligp4ak	312	70	crystalloid	crystalloid	NN
cord-018834-4ligp4ak	312	71	on	on	IN
cord-018834-4ligp4ak	312	72	mortality	mortality	NN
cord-018834-4ligp4ak	312	73	in	in	IN
cord-018834-4ligp4ak	312	74	adult	adult	NN
cord-018834-4ligp4ak	312	75	patients	patient	NNS
cord-018834-4ligp4ak	312	76	with	with	IN
cord-018834-4ligp4ak	312	77	severe	severe	JJ
cord-018834-4ligp4ak	312	78	sepsis	sepsis	NN
cord-018834-4ligp4ak	312	79	and	and	CC
cord-018834-4ligp4ak	312	80	septic	septic	JJ
cord-018834-4ligp4ak	312	81	shock	shock	NN
cord-018834-4ligp4ak	312	82	:	:	:
cord-018834-4ligp4ak	312	83	a	a	DT
cord-018834-4ligp4ak	312	84	metaanalysis	metaanalysis	NN
cord-018834-4ligp4ak	312	85	of	of	IN
cord-018834-4ligp4ak	312	86	randomized	randomized	JJ
cord-018834-4ligp4ak	312	87	clinical	clinical	JJ
cord-018834-4ligp4ak	312	88	trials	trial	NNS
cord-018834-4ligp4ak	312	89	Plasma	Plasma	NNP
cord-018834-4ligp4ak	312	90	volume	volume	NN
cord-018834-4ligp4ak	312	91	expansion	expansion	NN
cord-018834-4ligp4ak	312	92	with	with	IN
cord-018834-4ligp4ak	312	93	5	5	CD
cord-018834-4ligp4ak	312	94	%	%	NN
cord-018834-4ligp4ak	312	95	albumin	albumin	NN
cord-018834-4ligp4ak	312	96	compared	compare	VBN
cord-018834-4ligp4ak	312	97	to	to	IN
cord-018834-4ligp4ak	312	98	ringer	ringer	NNP
cord-018834-4ligp4ak	312	99	's	's	POS
cord-018834-4ligp4ak	312	100	acetate	acetate	NN
cord-018834-4ligp4ak	312	101	during	during	IN
cord-018834-4ligp4ak	312	102	normal	normal	JJ
cord-018834-4ligp4ak	312	103	and	and	CC
cord-018834-4ligp4ak	312	104	increased	increased	JJ
cord-018834-4ligp4ak	312	105	microvascular	microvascular	JJ
cord-018834-4ligp4ak	312	106	permeability	permeability	NN
cord-018834-4ligp4ak	312	107	in	in	IN
cord-018834-4ligp4ak	312	108	the	the	DT
cord-018834-4ligp4ak	312	109	rat	rat	NN
cord-018834-4ligp4ak	312	110	Albumin	Albumin	NNP
cord-018834-4ligp4ak	312	111	reduces	reduce	VBZ
cord-018834-4ligp4ak	312	112	paracentesis	paracentesis	NN
cord-018834-4ligp4ak	312	113	-	-	HYPH
cord-018834-4ligp4ak	312	114	induced	induce	VBN
cord-018834-4ligp4ak	312	115	circulatory	circulatory	JJ
cord-018834-4ligp4ak	312	116	dysfunction	dysfunction	NN
cord-018834-4ligp4ak	312	117	and	and	CC
cord-018834-4ligp4ak	312	118	reduces	reduce	VBZ
cord-018834-4ligp4ak	312	119	death	death	NN
cord-018834-4ligp4ak	312	120	and	and	CC
cord-018834-4ligp4ak	312	121	renal	renal	JJ
cord-018834-4ligp4ak	312	122	impairment	impairment	NN
cord-018834-4ligp4ak	312	123	among	among	IN
cord-018834-4ligp4ak	312	124	patients	patient	NNS
cord-018834-4ligp4ak	312	125	with	with	IN
cord-018834-4ligp4ak	312	126	cirrhosis	cirrhosis	NN
cord-018834-4ligp4ak	312	127	and	and	CC
cord-018834-4ligp4ak	312	128	infection	infection	NN
cord-018834-4ligp4ak	312	129	:	:	:
cord-018834-4ligp4ak	312	130	a	a	DT
cord-018834-4ligp4ak	312	131	systematic	systematic	JJ
cord-018834-4ligp4ak	312	132	review	review	NN
cord-018834-4ligp4ak	312	133	and	and	CC
cord-018834-4ligp4ak	312	134	meta	meta	NNP
cord-018834-4ligp4ak	312	135	-	-	HYPH
cord-018834-4ligp4ak	312	136	analysis	analysis	NN
cord-018834-4ligp4ak	312	137	Effect	effect	NN
cord-018834-4ligp4ak	312	138	of	of	IN
cord-018834-4ligp4ak	312	139	intravenous	intravenous	JJ
cord-018834-4ligp4ak	312	140	albumin	albumin	NN
cord-018834-4ligp4ak	312	141	on	on	IN
cord-018834-4ligp4ak	312	142	renal	renal	JJ
cord-018834-4ligp4ak	312	143	impairment	impairment	NN
cord-018834-4ligp4ak	312	144	and	and	CC
cord-018834-4ligp4ak	312	145	mortality	mortality	NN
cord-018834-4ligp4ak	312	146	in	in	IN
cord-018834-4ligp4ak	312	147	patients	patient	NNS
cord-018834-4ligp4ak	312	148	with	with	IN
cord-018834-4ligp4ak	312	149	cirrhosis	cirrhosis	NN
cord-018834-4ligp4ak	312	150	and	and	CC
cord-018834-4ligp4ak	312	151	spontaneous	spontaneous	JJ
cord-018834-4ligp4ak	312	152	bacterial	bacterial	JJ
cord-018834-4ligp4ak	312	153	peritonitis	peritonitis	NN
cord-018834-4ligp4ak	312	154	Albumin	albumin	NN
cord-018834-4ligp4ak	312	155	versus	versus	IN
cord-018834-4ligp4ak	312	156	crystalloid	crystalloid	NNP
cord-018834-4ligp4ak	312	157	solutions	solution	NNS
cord-018834-4ligp4ak	312	158	in	in	IN
cord-018834-4ligp4ak	312	159	patients	patient	NNS
cord-018834-4ligp4ak	312	160	with	with	IN
cord-018834-4ligp4ak	312	161	the	the	DT
cord-018834-4ligp4ak	312	162	acute	acute	JJ
cord-018834-4ligp4ak	312	163	respiratory	respiratory	JJ
cord-018834-4ligp4ak	312	164	distress	distress	NN
cord-018834-4ligp4ak	312	165	syndrome	syndrome	NN
cord-018834-4ligp4ak	312	166	:	:	:
cord-018834-4ligp4ak	312	167	a	a	DT
cord-018834-4ligp4ak	312	168	systematic	systematic	JJ
cord-018834-4ligp4ak	312	169	review	review	NN
cord-018834-4ligp4ak	312	170	and	and	CC
cord-018834-4ligp4ak	312	171	meta	meta	NNP
cord-018834-4ligp4ak	312	172	-	-	HYPH
cord-018834-4ligp4ak	312	173	analysis	analysis	NN
cord-018834-4ligp4ak	312	174	Mortality	mortality	NN
cord-018834-4ligp4ak	312	175	after	after	IN
cord-018834-4ligp4ak	312	176	fl	fl	NNP
cord-018834-4ligp4ak	312	177	uid	uid	NN
cord-018834-4ligp4ak	312	178	bolus	bolus	NN
cord-018834-4ligp4ak	312	179	in	in	IN
cord-018834-4ligp4ak	312	180	African	african	JJ
cord-018834-4ligp4ak	312	181	children	child	NNS
cord-018834-4ligp4ak	312	182	with	with	IN
cord-018834-4ligp4ak	312	183	severe	severe	JJ
cord-018834-4ligp4ak	312	184	infection	infection	NN
cord-018834-4ligp4ak	312	185	Albumin	albumin	NN
cord-018834-4ligp4ak	312	186	therapy	therapy	NN
cord-018834-4ligp4ak	312	187	of	of	IN
cord-018834-4ligp4ak	312	188	transient	transient	JJ
cord-018834-4ligp4ak	312	189	focal	focal	JJ
cord-018834-4ligp4ak	312	190	cerebral	cerebral	JJ
cord-018834-4ligp4ak	312	191	ischemia	ischemia	NN
cord-018834-4ligp4ak	312	192	:	:	:
cord-018834-4ligp4ak	312	193	in	in	IN
cord-018834-4ligp4ak	312	194	vivo	vivo	NN
cord-018834-4ligp4ak	312	195	analysis	analysis	NN
cord-018834-4ligp4ak	312	196	of	of	IN
cord-018834-4ligp4ak	312	197	dynamic	dynamic	JJ
cord-018834-4ligp4ak	312	198	microvascular	microvascular	JJ
cord-018834-4ligp4ak	312	199	responses	response	NNS
cord-018834-4ligp4ak	312	200	fMRI	fMRI	NNP
cord-018834-4ligp4ak	312	201	of	of	IN
cord-018834-4ligp4ak	312	202	delayed	delayed	JJ
cord-018834-4ligp4ak	312	203	albumin	albumin	NN
cord-018834-4ligp4ak	312	204	treatment	treatment	NN
cord-018834-4ligp4ak	312	205	during	during	IN
cord-018834-4ligp4ak	312	206	stroke	stroke	NN
cord-018834-4ligp4ak	312	207	recovery	recovery	NN
cord-018834-4ligp4ak	312	208	in	in	IN
cord-018834-4ligp4ak	312	209	rats	rat	NNS
cord-018834-4ligp4ak	312	210	:	:	:
cord-018834-4ligp4ak	312	211	implication	implication	NN
cord-018834-4ligp4ak	312	212	for	for	IN
cord-018834-4ligp4ak	312	213	fast	fast	JJ
cord-018834-4ligp4ak	312	214	neuronal	neuronal	JJ
cord-018834-4ligp4ak	312	215	habituation	habituation	NN
cord-018834-4ligp4ak	312	216	in	in	IN
cord-018834-4ligp4ak	312	217	recovering	recover	VBG
cord-018834-4ligp4ak	312	218	brains	brain	NNS
cord-018834-4ligp4ak	313	1	Human	human	JJ
cord-018834-4ligp4ak	313	2	albumin	albumin	NN
cord-018834-4ligp4ak	313	3	improves	improve	VBZ
cord-018834-4ligp4ak	313	4	long	long	JJ
cord-018834-4ligp4ak	313	5	-	-	HYPH
cord-018834-4ligp4ak	313	6	term	term	NN
cord-018834-4ligp4ak	313	7	behavioral	behavioral	JJ
cord-018834-4ligp4ak	313	8	sequelae	sequela	NNS
cord-018834-4ligp4ak	313	9	after	after	IN
cord-018834-4ligp4ak	313	10	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	313	11	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	313	12	through	through	IN
cord-018834-4ligp4ak	313	13	neurovascular	neurovascular	JJ
cord-018834-4ligp4ak	313	14	remodeling	remodeling	NN
cord-018834-4ligp4ak	313	15	High	high	JJ
cord-018834-4ligp4ak	313	16	-	-	HYPH
cord-018834-4ligp4ak	313	17	dose	dose	NN
cord-018834-4ligp4ak	313	18	albumin	albumin	NN
cord-018834-4ligp4ak	313	19	treatment	treatment	NN
cord-018834-4ligp4ak	313	20	for	for	IN
cord-018834-4ligp4ak	313	21	acute	acute	JJ
cord-018834-4ligp4ak	313	22	ischaemic	ischaemic	JJ
cord-018834-4ligp4ak	313	23	stroke	stroke	NN
cord-018834-4ligp4ak	313	24	(	(	-LRB-
cord-018834-4ligp4ak	313	25	alias	alias	NNP
cord-018834-4ligp4ak	313	26	)	)	-RRB-
cord-018834-4ligp4ak	313	27	part	part	NN
cord-018834-4ligp4ak	313	28	2	2	CD
cord-018834-4ligp4ak	313	29	:	:	:
cord-018834-4ligp4ak	313	30	a	a	DT
cord-018834-4ligp4ak	313	31	randomised	randomised	JJ
cord-018834-4ligp4ak	313	32	,	,	,
cord-018834-4ligp4ak	313	33	double	double	JJ
cord-018834-4ligp4ak	313	34	-	-	HYPH
cord-018834-4ligp4ak	313	35	blind	blind	JJ
cord-018834-4ligp4ak	313	36	Effect	effect	NN
cord-018834-4ligp4ak	313	37	of	of	IN
cord-018834-4ligp4ak	313	38	human	human	JJ
cord-018834-4ligp4ak	313	39	albumin	albumin	NN
cord-018834-4ligp4ak	313	40	on	on	IN
cord-018834-4ligp4ak	313	41	TCD	TCD	NNP
cord-018834-4ligp4ak	313	42	vasospasm	vasospasm	NN
cord-018834-4ligp4ak	313	43	,	,	,
cord-018834-4ligp4ak	313	44	DCI	DCI	NNP
cord-018834-4ligp4ak	313	45	,	,	,
cord-018834-4ligp4ak	313	46	and	and	CC
cord-018834-4ligp4ak	313	47	cerebral	cerebral	JJ
cord-018834-4ligp4ak	313	48	infarction	infarction	NN
cord-018834-4ligp4ak	313	49	in	in	IN
cord-018834-4ligp4ak	313	50	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	313	51	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	313	52	:	:	:
cord-018834-4ligp4ak	314	1	the	the	DT
cord-018834-4ligp4ak	314	2	ALISAH	ALISAH	NNP
cord-018834-4ligp4ak	314	3	study	study	NN
cord-018834-4ligp4ak	314	4	The	the	DT
cord-018834-4ligp4ak	314	5	albumin	albumin	NN
cord-018834-4ligp4ak	314	6	in	in	IN
cord-018834-4ligp4ak	314	7	subarachnoid	subarachnoid	NN
cord-018834-4ligp4ak	314	8	hemorrhage	hemorrhage	NN
cord-018834-4ligp4ak	314	9	(	(	-LRB-
cord-018834-4ligp4ak	314	10	ALISAH	ALISAH	NNP
cord-018834-4ligp4ak	314	11	)	)	-RRB-
cord-018834-4ligp4ak	315	1	multicenter	multicenter	JJ
cord-018834-4ligp4ak	315	2	pilot	pilot	NNP
cord-018834-4ligp4ak	315	3	clinical	clinical	JJ
cord-018834-4ligp4ak	315	4	trial	trial	NN
cord-018834-4ligp4ak	315	5	:	:	:
cord-018834-4ligp4ak	315	6	safety	safety	NN
cord-018834-4ligp4ak	315	7	and	and	CC
cord-018834-4ligp4ak	315	8	neurologic	neurologic	JJ
cord-018834-4ligp4ak	315	9	outcomes	outcome	NNS
cord-018834-4ligp4ak	316	1	Albumin	albumin	NN
cord-018834-4ligp4ak	316	2	treatment	treatment	NN
cord-018834-4ligp4ak	316	3	reduces	reduce	VBZ
cord-018834-4ligp4ak	316	4	neurological	neurological	JJ
cord-018834-4ligp4ak	316	5	defi	defi	NNP
cord-018834-4ligp4ak	316	6	cit	cit	NNP
cord-018834-4ligp4ak	316	7	and	and	CC
cord-018834-4ligp4ak	316	8	protects	protect	VBZ
cord-018834-4ligp4ak	316	9	blood	blood	NN
cord-018834-4ligp4ak	316	10	-	-	HYPH
cord-018834-4ligp4ak	316	11	brain	brain	NN
cord-018834-4ligp4ak	316	12	barrier	barrier	NN
cord-018834-4ligp4ak	316	13	integrity	integrity	NN
cord-018834-4ligp4ak	316	14	after	after	IN
cord-018834-4ligp4ak	316	15	acute	acute	JJ
cord-018834-4ligp4ak	316	16	intracortical	intracortical	JJ
cord-018834-4ligp4ak	316	17	hematoma	hematoma	NN
cord-018834-4ligp4ak	316	18	in	in	IN
cord-018834-4ligp4ak	316	19	the	the	DT
cord-018834-4ligp4ak	316	20	rat	rat	NN
cord-018834-4ligp4ak	316	21	Serum	Serum	NNP
cord-018834-4ligp4ak	316	22	albumin	albumin	NN
cord-018834-4ligp4ak	316	23	is	be	VBZ
cord-018834-4ligp4ak	316	24	a	a	DT
cord-018834-4ligp4ak	316	25	specifi	specifi	NN
cord-018834-4ligp4ak	316	26	c	c	NN
cord-018834-4ligp4ak	316	27	inhibitor	inhibitor	NN
cord-018834-4ligp4ak	316	28	of	of	IN
cord-018834-4ligp4ak	316	29	apoptosis	apoptosis	NN
cord-018834-4ligp4ak	316	30	in	in	IN
cord-018834-4ligp4ak	316	31	human	human	JJ
cord-018834-4ligp4ak	316	32	endothelial	endothelial	JJ
cord-018834-4ligp4ak	316	33	cells	cell	NNS
cord-018834-4ligp4ak	316	34	Early	early	RB
cord-018834-4ligp4ak	316	35	albumin	albumin	NN
cord-018834-4ligp4ak	316	36	infusion	infusion	NN
cord-018834-4ligp4ak	316	37	improves	improve	VBZ
cord-018834-4ligp4ak	316	38	global	global	JJ
cord-018834-4ligp4ak	316	39	and	and	CC
cord-018834-4ligp4ak	316	40	local	local	JJ
cord-018834-4ligp4ak	316	41	hemodynamics	hemodynamic	NNS
cord-018834-4ligp4ak	316	42	and	and	CC
cord-018834-4ligp4ak	316	43	reduces	reduce	VBZ
cord-018834-4ligp4ak	316	44	infl	infl	NNP
cord-018834-4ligp4ak	316	45	ammatory	ammatory	NNP
cord-018834-4ligp4ak	316	46	response	response	NN
cord-018834-4ligp4ak	316	47	in	in	IN
cord-018834-4ligp4ak	316	48	hemorrhagic	hemorrhagic	JJ
cord-018834-4ligp4ak	316	49	shock	shock	NN
cord-018834-4ligp4ak	316	50	Albumin	albumin	NN
cord-018834-4ligp4ak	316	51	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	316	52	for	for	IN
cord-018834-4ligp4ak	316	53	traumatic	traumatic	JJ
cord-018834-4ligp4ak	316	54	brain	brain	NN
cord-018834-4ligp4ak	316	55	injury	injury	NN
cord-018834-4ligp4ak	316	56	:	:	:
cord-018834-4ligp4ak	316	57	is	be	VBZ
cord-018834-4ligp4ak	316	58	intracranial	intracranial	JJ
cord-018834-4ligp4ak	316	59	hypertension	hypertension	NN
cord-018834-4ligp4ak	316	60	the	the	DT
cord-018834-4ligp4ak	316	61	cause	cause	NN
cord-018834-4ligp4ak	316	62	of	of	IN
cord-018834-4ligp4ak	316	63	increased	increase	VBN
cord-018834-4ligp4ak	316	64	mortality	mortality	NN
cord-018834-4ligp4ak	316	65	?	?	.
cord-018834-4ligp4ak	317	1	Saline	saline	NN
cord-018834-4ligp4ak	317	2	or	or	CC
cord-018834-4ligp4ak	317	3	albumin	albumin	NN
cord-018834-4ligp4ak	317	4	for	for	IN
cord-018834-4ligp4ak	317	5	fl	fl	NNP
cord-018834-4ligp4ak	317	6	uid	uid	NN
cord-018834-4ligp4ak	317	7	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	317	8	in	in	IN
cord-018834-4ligp4ak	317	9	patients	patient	NNS
cord-018834-4ligp4ak	317	10	with	with	IN
cord-018834-4ligp4ak	317	11	traumatic	traumatic	JJ
cord-018834-4ligp4ak	317	12	brain	brain	NN
cord-018834-4ligp4ak	317	13	injury	injury	NN
cord-018834-4ligp4ak	317	14	Fluid	Fluid	NNP
cord-018834-4ligp4ak	317	15	therapy	therapy	NN
cord-018834-4ligp4ak	317	16	and	and	CC
cord-018834-4ligp4ak	317	17	the	the	DT
cord-018834-4ligp4ak	317	18	use	use	NN
cord-018834-4ligp4ak	317	19	of	of	IN
cord-018834-4ligp4ak	317	20	albumin	albumin	NN
cord-018834-4ligp4ak	317	21	in	in	IN
cord-018834-4ligp4ak	317	22	the	the	DT
cord-018834-4ligp4ak	317	23	treatment	treatment	NN
cord-018834-4ligp4ak	317	24	of	of	IN
cord-018834-4ligp4ak	317	25	severe	severe	JJ
cord-018834-4ligp4ak	317	26	traumatic	traumatic	JJ
cord-018834-4ligp4ak	317	27	brain	brain	NN
cord-018834-4ligp4ak	317	28	injury	injury	NN
cord-018834-4ligp4ak	317	29	Fluid	Fluid	NNP
cord-018834-4ligp4ak	317	30	resuscitation	resuscitation	NN
cord-018834-4ligp4ak	317	31	in	in	IN
cord-018834-4ligp4ak	317	32	patients	patient	NNS
cord-018834-4ligp4ak	317	33	with	with	IN
cord-018834-4ligp4ak	317	34	traumatic	traumatic	JJ
cord-018834-4ligp4ak	317	35	brain	brain	NN
cord-018834-4ligp4ak	317	36	injury	injury	NN
cord-018834-4ligp4ak	317	37	:	:	:
cord-018834-4ligp4ak	317	38	what	what	WP
cord-018834-4ligp4ak	317	39	is	be	VBZ
cord-018834-4ligp4ak	317	40	a	a	DT
cord-018834-4ligp4ak	317	41	safe	safe	JJ
cord-018834-4ligp4ak	317	42	approach	approach	NN
cord-018834-4ligp4ak	317	43	?	?	.
cord-018834-4ligp4ak	318	1	Albumin	albumin	NN
cord-018834-4ligp4ak	318	2	-	-	HYPH
cord-018834-4ligp4ak	318	3	beyond	beyond	IN
cord-018834-4ligp4ak	318	4	fl	fl	NNP
cord-018834-4ligp4ak	318	5	uid	uid	NN
cord-018834-4ligp4ak	318	6	replacement	replacement	NN
cord-018834-4ligp4ak	318	7	in	in	IN
cord-018834-4ligp4ak	318	8	cardiopulmonary	cardiopulmonary	JJ
cord-018834-4ligp4ak	318	9	bypass	bypass	NN
cord-018834-4ligp4ak	318	10	surgery	surgery	NN
cord-018834-4ligp4ak	318	11	:	:	:
cord-018834-4ligp4ak	318	12	why	why	WRB
cord-018834-4ligp4ak	318	13	,	,	,
cord-018834-4ligp4ak	318	14	how	how	WRB
cord-018834-4ligp4ak	318	15	,	,	,
cord-018834-4ligp4ak	318	16	and	and	CC
cord-018834-4ligp4ak	318	17	when	when	WRB
cord-018834-4ligp4ak	318	18	?	?	.
cord-018834-4ligp4ak	319	1	Semin	Semin	NNP
cord-018834-4ligp4ak	319	2	Cardiothorac	Cardiothorac	NNP
cord-018834-4ligp4ak	319	3	Vasc	Vasc	NNP
cord-018834-4ligp4ak	319	4	Anesth	Anesth	NNP
cord-018834-4ligp4ak	319	5	Blood	Blood	NNP
cord-018834-4ligp4ak	319	6	loss	loss	NN
cord-018834-4ligp4ak	319	7	in	in	IN
cord-018834-4ligp4ak	319	8	infants	infant	NNS
cord-018834-4ligp4ak	319	9	and	and	CC
cord-018834-4ligp4ak	319	10	children	child	NNS
cord-018834-4ligp4ak	319	11	for	for	IN
cord-018834-4ligp4ak	319	12	open	open	JJ
cord-018834-4ligp4ak	319	13	heart	heart	NN
cord-018834-4ligp4ak	319	14	operations	operation	NNS
cord-018834-4ligp4ak	319	15	:	:	:
cord-018834-4ligp4ak	320	1	albumin	albumin	NN
cord-018834-4ligp4ak	320	2	5	5	CD
cord-018834-4ligp4ak	320	3	%	%	NN
cord-018834-4ligp4ak	320	4	versus	versus	IN
cord-018834-4ligp4ak	320	5	fresh	fresh	JJ
cord-018834-4ligp4ak	320	6	-	-	HYPH
cord-018834-4ligp4ak	320	7	frozen	frozen	JJ
cord-018834-4ligp4ak	320	8	plasma	plasma	NN
cord-018834-4ligp4ak	320	9	in	in	IN
cord-018834-4ligp4ak	320	10	the	the	DT
cord-018834-4ligp4ak	320	11	prime	prime	JJ
cord-018834-4ligp4ak	320	12	Albumin	Albumin	NNP
cord-018834-4ligp4ak	320	13	versus	versus	IN
cord-018834-4ligp4ak	320	14	crystalloid	crystalloid	NN
cord-018834-4ligp4ak	320	15	for	for	IN
cord-018834-4ligp4ak	320	16	pump	pump	NN
cord-018834-4ligp4ak	320	17	priming	prime	VBG
cord-018834-4ligp4ak	320	18	in	in	IN
cord-018834-4ligp4ak	320	19	cardiac	cardiac	JJ
cord-018834-4ligp4ak	320	20	surgery	surgery	NN
cord-018834-4ligp4ak	320	21	:	:	:
cord-018834-4ligp4ak	320	22	meta	meta	NNP
cord-018834-4ligp4ak	320	23	-	-	HYPH
cord-018834-4ligp4ak	320	24	analysis	analysis	NN
cord-018834-4ligp4ak	320	25	of	of	IN
cord-018834-4ligp4ak	320	26	controlled	control	VBN
cord-018834-4ligp4ak	320	27	trials	trial	NNS
cord-018834-4ligp4ak	320	28	Rapidly	rapidly	RB
cord-018834-4ligp4ak	320	29	degradable	degradable	JJ
cord-018834-4ligp4ak	320	30	hydroxyethyl	hydroxyethyl	NN
cord-018834-4ligp4ak	320	31	starch	starch	NN
cord-018834-4ligp4ak	320	32	solutions	solution	NNS
cord-018834-4ligp4ak	320	33	impair	impair	VBP
cord-018834-4ligp4ak	320	34	blood	blood	NN
cord-018834-4ligp4ak	320	35	coagulation	coagulation	NN
cord-018834-4ligp4ak	320	36	after	after	IN
cord-018834-4ligp4ak	320	37	cardiac	cardiac	JJ
cord-018834-4ligp4ak	320	38	surgery	surgery	NN
cord-018834-4ligp4ak	320	39	:	:	:
cord-018834-4ligp4ak	320	40	a	a	DT
cord-018834-4ligp4ak	320	41	prospective	prospective	JJ
cord-018834-4ligp4ak	320	42	randomized	randomized	JJ
cord-018834-4ligp4ak	320	43	trial	trial	NN
cord-018834-4ligp4ak	320	44	Gelatin	gelatin	NN
cord-018834-4ligp4ak	320	45	and	and	CC
cord-018834-4ligp4ak	320	46	hydroxyethyl	hydroxyethyl	NN
cord-018834-4ligp4ak	320	47	starch	starch	NN
cord-018834-4ligp4ak	320	48	,	,	,
cord-018834-4ligp4ak	320	49	but	but	CC
cord-018834-4ligp4ak	320	50	not	not	RB
cord-018834-4ligp4ak	320	51	albumin	albumin	NN
cord-018834-4ligp4ak	320	52	,	,	,
cord-018834-4ligp4ak	320	53	impair	impair	VB
cord-018834-4ligp4ak	320	54	hemostasis	hemostasis	NN
cord-018834-4ligp4ak	320	55	after	after	IN
cord-018834-4ligp4ak	320	56	cardiac	cardiac	JJ
cord-018834-4ligp4ak	320	57	surgery	surgery	NN
cord-018834-4ligp4ak	320	58	Effect	effect	NN
cord-018834-4ligp4ak	320	59	of	of	IN
cord-018834-4ligp4ak	320	60	hydroxyethyl	hydroxyethyl	NN
cord-018834-4ligp4ak	320	61	starch	starch	NN
cord-018834-4ligp4ak	320	62	on	on	IN
cord-018834-4ligp4ak	320	63	bleeding	bleed	VBG
cord-018834-4ligp4ak	320	64	after	after	IN
cord-018834-4ligp4ak	320	65	cardiopulmonary	cardiopulmonary	JJ
cord-018834-4ligp4ak	320	66	bypass	bypass	NN
cord-018834-4ligp4ak	320	67	:	:	:
cord-018834-4ligp4ak	321	1	a	a	DT
cord-018834-4ligp4ak	321	2	meta	meta	JJ
cord-018834-4ligp4ak	321	3	-	-	HYPH
cord-018834-4ligp4ak	321	4	analysis	analysis	NN
cord-018834-4ligp4ak	321	5	of	of	IN
cord-018834-4ligp4ak	321	6	randomized	randomized	JJ
cord-018834-4ligp4ak	321	7	trials	trial	NNS
cord-018834-4ligp4ak	322	1	Post	post	JJ
cord-018834-4ligp4ak	322	2	-	-	JJ
cord-018834-4ligp4ak	322	3	operative	operative	JJ
cord-018834-4ligp4ak	322	4	hypoalbuminaemia	hypoalbuminaemia	NN
cord-018834-4ligp4ak	322	5	and	and	CC
cord-018834-4ligp4ak	322	6	procalcitonin	procalcitonin	NNP
cord-018834-4ligp4ak	322	7	elevation	elevation	NN
cord-018834-4ligp4ak	322	8	for	for	IN
cord-018834-4ligp4ak	322	9	prediction	prediction	NN
cord-018834-4ligp4ak	322	10	of	of	IN
cord-018834-4ligp4ak	322	11	outcome	outcome	NN
cord-018834-4ligp4ak	322	12	in	in	IN
cord-018834-4ligp4ak	322	13	cardiopulmonary	cardiopulmonary	JJ
cord-018834-4ligp4ak	322	14	bypass	bypass	NN
cord-018834-4ligp4ak	322	15	surgery	surgery	NN
cord-018834-4ligp4ak	322	16	Albumin	albumin	NN
cord-018834-4ligp4ak	322	17	supplementation	supplementation	NN
cord-018834-4ligp4ak	322	18	as	as	IN
cord-018834-4ligp4ak	322	19	a	a	DT
cord-018834-4ligp4ak	322	20	therapeutic	therapeutic	JJ
cord-018834-4ligp4ak	322	21	strategy	strategy	NN
cord-018834-4ligp4ak	322	22	in	in	IN
cord-018834-4ligp4ak	322	23	cardiac	cardiac	JJ
cord-018834-4ligp4ak	322	24	surgery	surgery	NN
cord-018834-4ligp4ak	322	25	:	:	:
cord-018834-4ligp4ak	322	26	useful	useful	JJ
cord-018834-4ligp4ak	322	27	tool	tool	NN
cord-018834-4ligp4ak	322	28	or	or	CC
cord-018834-4ligp4ak	322	29	expensive	expensive	JJ
cord-018834-4ligp4ak	322	30	hobby	hobby	NN
cord-018834-4ligp4ak	322	31	?	?	.
cord-018834-4ligp4ak	323	1	Effect	effect	NN
cord-018834-4ligp4ak	323	2	of	of	IN
cord-018834-4ligp4ak	323	3	exogenous	exogenous	JJ
cord-018834-4ligp4ak	323	4	albumin	albumin	NN
cord-018834-4ligp4ak	323	5	on	on	IN
cord-018834-4ligp4ak	323	6	the	the	DT
cord-018834-4ligp4ak	323	7	incidence	incidence	NN
cord-018834-4ligp4ak	323	8	of	of	IN
cord-018834-4ligp4ak	323	9	postoperative	postoperative	JJ
cord-018834-4ligp4ak	323	10	acute	acute	JJ
cord-018834-4ligp4ak	323	11	kidney	kidney	NN
cord-018834-4ligp4ak	323	12	injury	injury	NN
cord-018834-4ligp4ak	323	13	in	in	IN
cord-018834-4ligp4ak	323	14	patients	patient	NNS
cord-018834-4ligp4ak	323	15	undergoing	undergo	VBG
cord-018834-4ligp4ak	323	16	off	off	IN
cord-018834-4ligp4ak	323	17	-	-	HYPH
cord-018834-4ligp4ak	323	18	pump	pump	NN
cord-018834-4ligp4ak	323	19	coronary	coronary	JJ
cord-018834-4ligp4ak	323	20	artery	artery	NN
cord-018834-4ligp4ak	323	21	bypass	bypass	NN
cord-018834-4ligp4ak	323	22	surgery	surgery	NN
cord-018834-4ligp4ak	323	23	with	with	IN
cord-018834-4ligp4ak	323	24	a	a	DT
cord-018834-4ligp4ak	323	25	preoperative	preoperative	JJ
cord-018834-4ligp4ak	323	26	albumin	albumin	NN
cord-018834-4ligp4ak	323	27	level	level	NN
cord-018834-4ligp4ak	323	28	of	of	IN
cord-018834-4ligp4ak	323	29	less	less	JJR
cord-018834-4ligp4ak	323	30	than	than	IN
cord-018834-4ligp4ak	323	31	4.0	4.0	CD
cord-018834-4ligp4ak	323	32	g	g	NN
cord-018834-4ligp4ak	323	33	/	/	SYM
cord-018834-4ligp4ak	323	34	dl	dl	NNP
cord-018834-4ligp4ak	323	35	Prion	Prion	NNP
cord-018834-4ligp4ak	323	36	-	-	HYPH
cord-018834-4ligp4ak	323	37	removal	removal	NN
cord-018834-4ligp4ak	323	38	capacity	capacity	NN
cord-018834-4ligp4ak	323	39	of	of	IN
cord-018834-4ligp4ak	323	40	chromatographic	chromatographic	JJ
cord-018834-4ligp4ak	323	41	and	and	CC
cord-018834-4ligp4ak	323	42	ethanol	ethanol	NN
cord-018834-4ligp4ak	323	43	precipitation	precipitation	NN
cord-018834-4ligp4ak	323	44	steps	step	NNS
cord-018834-4ligp4ak	323	45	used	use	VBN
cord-018834-4ligp4ak	323	46	in	in	IN
cord-018834-4ligp4ak	323	47	the	the	DT
cord-018834-4ligp4ak	323	48	production	production	NN
cord-018834-4ligp4ak	323	49	of	of	IN
cord-018834-4ligp4ak	323	50	albumin	albumin	NN
cord-018834-4ligp4ak	323	51	and	and	CC
cord-018834-4ligp4ak	323	52	immunoglobulins	immunoglobulin	NNS
cord-018834-4ligp4ak	323	53	Safety	Safety	NNP
cord-018834-4ligp4ak	323	54	of	of	IN
cord-018834-4ligp4ak	323	55	human	human	JJ
cord-018834-4ligp4ak	323	56	albumin	albumin	NN
cord-018834-4ligp4ak	324	1	-serious	-serious	JJ
cord-018834-4ligp4ak	324	2	adverse	adverse	JJ
cord-018834-4ligp4ak	324	3	events	event	NNS
cord-018834-4ligp4ak	324	4	reported	report	VBN
cord-018834-4ligp4ak	324	5	worldwide	worldwide	RB
cord-018834-4ligp4ak	324	6	in	in	IN
cord-018834-4ligp4ak	324	7	1998	1998	CD
cord-018834-4ligp4ak	324	8	-	-	SYM
cord-018834-4ligp4ak	324	9	2000	2000	CD
cord-018834-4ligp4ak	324	10	Albumin	Albumin	NNP
cord-018834-4ligp4ak	324	11	administration	administration	NN
cord-018834-4ligp4ak	324	12	in	in	IN
cord-018834-4ligp4ak	324	13	the	the	DT
cord-018834-4ligp4ak	324	14	acutely	acutely	RB
cord-018834-4ligp4ak	324	15	ill	ill	JJ
cord-018834-4ligp4ak	324	16	:	:	:
cord-018834-4ligp4ak	324	17	what	what	WP
cord-018834-4ligp4ak	324	18	is	be	VBZ
cord-018834-4ligp4ak	324	19	new	new	JJ
cord-018834-4ligp4ak	324	20	and	and	CC
cord-018834-4ligp4ak	324	21	where	where	WRB
cord-018834-4ligp4ak	324	22	next	next	JJ
cord-018834-4ligp4ak	324	23	?	?	.
cord-018834-4ligp4ak	325	1	Heterogeneity	heterogeneity	NN
cord-018834-4ligp4ak	325	2	and	and	CC
cord-018834-4ligp4ak	325	3	oxidation	oxidation	NN
cord-018834-4ligp4ak	325	4	status	status	NN
cord-018834-4ligp4ak	325	5	of	of	IN
cord-018834-4ligp4ak	325	6	commercial	commercial	JJ
cord-018834-4ligp4ak	325	7	human	human	JJ
cord-018834-4ligp4ak	325	8	albumin	albumin	NN
cord-018834-4ligp4ak	325	9	preparations	preparation	NNS
cord-018834-4ligp4ak	325	10	in	in	IN
cord-018834-4ligp4ak	325	11	clinical	clinical	JJ
cord-018834-4ligp4ak	325	12	use	use	NN
cord-018834-4ligp4ak	325	13	Pharmacological	pharmacological	JJ
cord-018834-4ligp4ak	325	14	aspects	aspect	NNS
cord-018834-4ligp4ak	325	15	of	of	IN
cord-018834-4ligp4ak	325	16	albumin	albumin	NN
cord-018834-4ligp4ak	325	17	as	as	IN
cord-018834-4ligp4ak	325	18	a	a	DT
cord-018834-4ligp4ak	325	19	niche	niche	NN
cord-018834-4ligp4ak	325	20	product	product	NN
cord-018834-4ligp4ak	325	21	in	in	IN
cord-018834-4ligp4ak	325	22	the	the	DT
cord-018834-4ligp4ak	325	23	intensive	intensive	JJ
cord-018834-4ligp4ak	325	24	care	care	NN
cord-018834-4ligp4ak	325	25	unit	unit	NN
cord-018834-4ligp4ak	325	26	Changes	change	NNS
cord-018834-4ligp4ak	325	27	in	in	IN
cord-018834-4ligp4ak	325	28	intravascular	intravascular	JJ
cord-018834-4ligp4ak	325	29	volume	volume	NN
cord-018834-4ligp4ak	325	30	during	during	IN
cord-018834-4ligp4ak	325	31	acute	acute	JJ
cord-018834-4ligp4ak	325	32	normovolemic	normovolemic	JJ
cord-018834-4ligp4ak	325	33	hemodilution	hemodilution	NN
cord-018834-4ligp4ak	325	34	and	and	CC
cord-018834-4ligp4ak	325	35	intraoperative	intraoperative	JJ
cord-018834-4ligp4ak	325	36	retransfusion	retransfusion	NN
cord-018834-4ligp4ak	325	37	in	in	IN
cord-018834-4ligp4ak	325	38	patients	patient	NNS
cord-018834-4ligp4ak	325	39	with	with	IN
cord-018834-4ligp4ak	325	40	radical	radical	JJ
cord-018834-4ligp4ak	325	41	hysterectomy	hysterectomy	NN
cord-018834-4ligp4ak	325	42	Human	Human	NNP
cord-018834-4ligp4ak	325	43	serum	serum	NN
cord-018834-4ligp4ak	325	44	albumin	albumin	NN
cord-018834-4ligp4ak	325	45	from	from	IN
cord-018834-4ligp4ak	325	46	recombinant	recombinant	JJ
cord-018834-4ligp4ak	325	47	DNA	dna	NN
cord-018834-4ligp4ak	325	48	technology	technology	NN
cord-018834-4ligp4ak	325	49	:	:	:
cord-018834-4ligp4ak	325	50	challenges	challenge	NNS
cord-018834-4ligp4ak	325	51	and	and	CC
cord-018834-4ligp4ak	325	52	strategies	strategy	NNS
cord-018834-4ligp4ak	325	53	Large	large	JJ
cord-018834-4ligp4ak	325	54	-	-	HYPH
cord-018834-4ligp4ak	325	55	scale	scale	NN
cord-018834-4ligp4ak	325	56	production	production	NN
cord-018834-4ligp4ak	325	57	of	of	IN
cord-018834-4ligp4ak	325	58	functional	functional	JJ
cord-018834-4ligp4ak	325	59	human	human	JJ
cord-018834-4ligp4ak	325	60	serum	serum	NN
cord-018834-4ligp4ak	325	61	albumin	albumin	NN
cord-018834-4ligp4ak	325	62	from	from	IN
cord-018834-4ligp4ak	325	63	transgenic	transgenic	JJ
cord-018834-4ligp4ak	325	64	rice	rice	NN
cord-018834-4ligp4ak	325	65	seeds	seed	NNS
cord-018834-4ligp4ak	325	66	Albumin	Albumin	NNP
cord-018834-4ligp4ak	325	67	as	as	IN
cord-018834-4ligp4ak	325	68	a	a	DT
cord-018834-4ligp4ak	325	69	drug	drug	NN
cord-018834-4ligp4ak	325	70	carrier	carrier	NN
cord-018834-4ligp4ak	325	71	:	:	:
cord-018834-4ligp4ak	325	72	design	design	NN
cord-018834-4ligp4ak	325	73	of	of	IN
cord-018834-4ligp4ak	325	74	prodrugs	prodrug	NNS
cord-018834-4ligp4ak	325	75	,	,	,
cord-018834-4ligp4ak	325	76	drug	drug	NN
cord-018834-4ligp4ak	325	77	conjugates	conjugate	NNS
cord-018834-4ligp4ak	325	78	and	and	CC
cord-018834-4ligp4ak	325	79	nanoparticles	nanoparticle	NNS
cord-018834-4ligp4ak	325	80	Redox	Redox	NNP
cord-018834-4ligp4ak	325	81	properties	property	NNS
cord-018834-4ligp4ak	325	82	of	of	IN
cord-018834-4ligp4ak	325	83	serum	serum	NN
cord-018834-4ligp4ak	325	84	albumin	albumin	NN
cord-018834-4ligp4ak	326	1	The	the	DT
cord-018834-4ligp4ak	326	2	thiol	thiol	NN
cord-018834-4ligp4ak	326	3	pool	pool	NN
cord-018834-4ligp4ak	326	4	in	in	IN
cord-018834-4ligp4ak	326	5	human	human	JJ
cord-018834-4ligp4ak	326	6	plasma	plasma	NN
cord-018834-4ligp4ak	326	7	:	:	:
cord-018834-4ligp4ak	326	8	the	the	DT
cord-018834-4ligp4ak	326	9	central	central	JJ
cord-018834-4ligp4ak	326	10	contribution	contribution	NN
cord-018834-4ligp4ak	326	11	of	of	IN
cord-018834-4ligp4ak	326	12	albumin	albumin	NN
cord-018834-4ligp4ak	326	13	to	to	IN
cord-018834-4ligp4ak	326	14	redox	redox	NN
cord-018834-4ligp4ak	326	15	processes	process	NNS