id sid tid token lemma pos cord-331343-qzvwwca9 1 1 key key NN cord-331343-qzvwwca9 1 2 : : : cord-331343-qzvwwca9 1 3 cord-331343-qzvwwca9 cord-331343-qzvwwca9 NNP cord-331343-qzvwwca9 1 4 authors author NNS cord-331343-qzvwwca9 1 5 : : : cord-331343-qzvwwca9 1 6 Mason Mason NNP cord-331343-qzvwwca9 1 7 , , , cord-331343-qzvwwca9 1 8 Andrew Andrew NNP cord-331343-qzvwwca9 1 9 L. L. NNP cord-331343-qzvwwca9 1 10 ; ; : cord-331343-qzvwwca9 1 11 Doucette Doucette NNP cord-331343-qzvwwca9 1 12 , , , cord-331343-qzvwwca9 1 13 Karen Karen NNP cord-331343-qzvwwca9 1 14 ; ; : cord-331343-qzvwwca9 1 15 Wong Wong NNP cord-331343-qzvwwca9 1 16 , , , cord-331343-qzvwwca9 1 17 Gane Gane NNP cord-331343-qzvwwca9 1 18 Ka‐Shu Ka‐Shu NNP cord-331343-qzvwwca9 2 1 title title NN cord-331343-qzvwwca9 2 2 : : : cord-331343-qzvwwca9 2 3 Metagenomics Metagenomics NNP cord-331343-qzvwwca9 2 4 and and CC cord-331343-qzvwwca9 2 5 the the DT cord-331343-qzvwwca9 2 6 case case NN cord-331343-qzvwwca9 2 7 of of IN cord-331343-qzvwwca9 2 8 the the DT cord-331343-qzvwwca9 2 9 deadly deadly JJ cord-331343-qzvwwca9 2 10 hamster hamster NN cord-331343-qzvwwca9 2 11 date date NN cord-331343-qzvwwca9 2 12 : : : cord-331343-qzvwwca9 2 13 2008 2008 CD cord-331343-qzvwwca9 2 14 - - SYM cord-331343-qzvwwca9 2 15 06 06 CD cord-331343-qzvwwca9 2 16 - - HYPH cord-331343-qzvwwca9 2 17 09 09 CD cord-331343-qzvwwca9 2 18 journal journal NN cord-331343-qzvwwca9 2 19 : : : cord-331343-qzvwwca9 2 20 Hepatology Hepatology NNP cord-331343-qzvwwca9 2 21 DOI DOI NNP cord-331343-qzvwwca9 2 22 : : : cord-331343-qzvwwca9 2 23 10.1002 10.1002 CD cord-331343-qzvwwca9 2 24 / / SYM cord-331343-qzvwwca9 2 25 hep.22452 hep.22452 NN cord-331343-qzvwwca9 2 26 sha sha NN cord-331343-qzvwwca9 2 27 : : : cord-331343-qzvwwca9 2 28 dce5b4fe87bf76159cd754d258a8570b3e82162f dce5b4fe87bf76159cd754d258a8570b3e82162f NNP cord-331343-qzvwwca9 2 29 doc_id doc_id NNP cord-331343-qzvwwca9 2 30 : : : cord-331343-qzvwwca9 2 31 331343 331343 CD cord-331343-qzvwwca9 2 32 cord_uid cord_uid NNS cord-331343-qzvwwca9 2 33 : : : cord-331343-qzvwwca9 3 1 qzvwwca9 qzvwwca9 NNP cord-331343-qzvwwca9 3 2 nan nan NNP cord-331343-qzvwwca9 4 1 The the DT cord-331343-qzvwwca9 4 2 article article NN cord-331343-qzvwwca9 4 3 by by IN cord-331343-qzvwwca9 4 4 Palacios Palacios NNP cord-331343-qzvwwca9 4 5 and and CC cord-331343-qzvwwca9 4 6 colleagues colleague NNS cord-331343-qzvwwca9 4 7 1 1 CD cord-331343-qzvwwca9 4 8 documents document NNS cord-331343-qzvwwca9 4 9 three three CD cord-331343-qzvwwca9 4 10 transplant transplant NN cord-331343-qzvwwca9 4 11 recipients recipient NNS cord-331343-qzvwwca9 4 12 who who WP cord-331343-qzvwwca9 4 13 shared share VBD cord-331343-qzvwwca9 4 14 the the DT cord-331343-qzvwwca9 4 15 same same JJ cord-331343-qzvwwca9 4 16 donor donor NN cord-331343-qzvwwca9 4 17 and and CC cord-331343-qzvwwca9 4 18 succumbed succumb VBD cord-331343-qzvwwca9 4 19 to to IN cord-331343-qzvwwca9 4 20 a a DT cord-331343-qzvwwca9 4 21 novel novel JJ cord-331343-qzvwwca9 4 22 arenavirus arenavirus NNP cord-331343-qzvwwca9 4 23 infection infection NN cord-331343-qzvwwca9 4 24 . . . cord-331343-qzvwwca9 5 1 Similar similar JJ cord-331343-qzvwwca9 5 2 events event NNS cord-331343-qzvwwca9 5 3 occurred occur VBD cord-331343-qzvwwca9 5 4 with with IN cord-331343-qzvwwca9 5 5 the the DT cord-331343-qzvwwca9 5 6 very very RB cord-331343-qzvwwca9 5 7 recent recent JJ cord-331343-qzvwwca9 5 8 infection infection NN cord-331343-qzvwwca9 5 9 of of IN cord-331343-qzvwwca9 5 10 two two CD cord-331343-qzvwwca9 5 11 kidney kidney NN cord-331343-qzvwwca9 5 12 recipients recipient NNS cord-331343-qzvwwca9 5 13 by by IN cord-331343-qzvwwca9 5 14 lymphocytic lymphocytic JJ cord-331343-qzvwwca9 5 15 choriomeningitis choriomeningitis NNP cord-331343-qzvwwca9 5 16 virus virus NN cord-331343-qzvwwca9 5 17 ( ( -LRB- cord-331343-qzvwwca9 5 18 LCMV LCMV NNP cord-331343-qzvwwca9 5 19 ) ) -RRB- cord-331343-qzvwwca9 5 20 from from IN cord-331343-qzvwwca9 5 21 a a DT cord-331343-qzvwwca9 5 22 single single JJ cord-331343-qzvwwca9 5 23 donor donor NN cord-331343-qzvwwca9 5 24 this this DT cord-331343-qzvwwca9 5 25 year year NN cord-331343-qzvwwca9 5 26 , , , cord-331343-qzvwwca9 5 27 2 2 CD cord-331343-qzvwwca9 5 28 and and CC cord-331343-qzvwwca9 5 29 this this DT cord-331343-qzvwwca9 5 30 complements complement VBZ cord-331343-qzvwwca9 5 31 a a DT cord-331343-qzvwwca9 5 32 report report NN cord-331343-qzvwwca9 5 33 from from IN cord-331343-qzvwwca9 5 34 2006 2006 CD cord-331343-qzvwwca9 5 35 detailing detail VBG cord-331343-qzvwwca9 5 36 other other JJ cord-331343-qzvwwca9 5 37 transplant transplant NN cord-331343-qzvwwca9 5 38 recipients recipient NNS cord-331343-qzvwwca9 5 39 dying die VBG cord-331343-qzvwwca9 5 40 from from IN cord-331343-qzvwwca9 5 41 LCMV LCMV NNP cord-331343-qzvwwca9 5 42 infection infection NN cord-331343-qzvwwca9 5 43 . . . cord-331343-qzvwwca9 6 1 3 3 LS cord-331343-qzvwwca9 7 1 In in IN cord-331343-qzvwwca9 7 2 the the DT cord-331343-qzvwwca9 7 3 latter latter JJ cord-331343-qzvwwca9 7 4 LCMV LCMV NNP cord-331343-qzvwwca9 7 5 clusters cluster NNS cord-331343-qzvwwca9 7 6 , , , cord-331343-qzvwwca9 7 7 the the DT cord-331343-qzvwwca9 7 8 timing timing NN cord-331343-qzvwwca9 7 9 of of IN cord-331343-qzvwwca9 7 10 infection infection NN cord-331343-qzvwwca9 7 11 and and CC cord-331343-qzvwwca9 7 12 viral viral JJ cord-331343-qzvwwca9 7 13 phylogenetic phylogenetic JJ cord-331343-qzvwwca9 7 14 analysis analysis NN cord-331343-qzvwwca9 7 15 left leave VBD cord-331343-qzvwwca9 7 16 little little JJ cord-331343-qzvwwca9 7 17 doubt doubt NN cord-331343-qzvwwca9 7 18 that that IN cord-331343-qzvwwca9 7 19 the the DT cord-331343-qzvwwca9 7 20 infections infection NNS cord-331343-qzvwwca9 7 21 were be VBD cord-331343-qzvwwca9 7 22 derived derive VBN cord-331343-qzvwwca9 7 23 from from IN cord-331343-qzvwwca9 7 24 a a DT cord-331343-qzvwwca9 7 25 point point NN cord-331343-qzvwwca9 7 26 source source NN cord-331343-qzvwwca9 7 27 . . . cord-331343-qzvwwca9 8 1 3 3 LS cord-331343-qzvwwca9 9 1 Even even RB cord-331343-qzvwwca9 9 2 though though IN cord-331343-qzvwwca9 9 3 there there EX cord-331343-qzvwwca9 9 4 was be VBD cord-331343-qzvwwca9 9 5 no no DT cord-331343-qzvwwca9 9 6 evidence evidence NN cord-331343-qzvwwca9 9 7 of of IN cord-331343-qzvwwca9 9 8 LCMV LCMV NNP cord-331343-qzvwwca9 9 9 infection infection NN cord-331343-qzvwwca9 9 10 in in IN cord-331343-qzvwwca9 9 11 the the DT cord-331343-qzvwwca9 9 12 two two CD cord-331343-qzvwwca9 9 13 donors donor NNS cord-331343-qzvwwca9 9 14 , , , cord-331343-qzvwwca9 9 15 both both DT cord-331343-qzvwwca9 9 16 suffered suffer VBD cord-331343-qzvwwca9 9 17 hemorrhagic hemorrhagic JJ cord-331343-qzvwwca9 9 18 intracranial intracranial JJ cord-331343-qzvwwca9 9 19 lesions lesion NNS cord-331343-qzvwwca9 9 20 consistent consistent JJ cord-331343-qzvwwca9 9 21 with with IN cord-331343-qzvwwca9 9 22 LCMV LCMV NNP cord-331343-qzvwwca9 9 23 infection infection NN cord-331343-qzvwwca9 9 24 , , , cord-331343-qzvwwca9 9 25 and and CC cord-331343-qzvwwca9 9 26 one one CD cord-331343-qzvwwca9 9 27 owned own VBD cord-331343-qzvwwca9 9 28 an an DT cord-331343-qzvwwca9 9 29 LCMV LCMV NNP cord-331343-qzvwwca9 9 30 - - HYPH cord-331343-qzvwwca9 9 31 infected infect VBN cord-331343-qzvwwca9 9 32 pet pet JJ cord-331343-qzvwwca9 9 33 hamster hamster NN cord-331343-qzvwwca9 9 34 . . . cord-331343-qzvwwca9 10 1 3 3 CD cord-331343-qzvwwca9 10 2 , , , cord-331343-qzvwwca9 10 3 4 4 CD cord-331343-qzvwwca9 11 1 The the DT cord-331343-qzvwwca9 11 2 report report NN cord-331343-qzvwwca9 11 3 by by IN cord-331343-qzvwwca9 11 4 Palacios Palacios NNP cord-331343-qzvwwca9 11 5 and and CC cord-331343-qzvwwca9 11 6 colleagues colleague NNS cord-331343-qzvwwca9 11 7 is be VBZ cord-331343-qzvwwca9 11 8 particularly particularly RB cord-331343-qzvwwca9 11 9 notable notable JJ cord-331343-qzvwwca9 11 10 because because IN cord-331343-qzvwwca9 11 11 of of IN cord-331343-qzvwwca9 11 12 the the DT cord-331343-qzvwwca9 11 13 methods method NNS cord-331343-qzvwwca9 11 14 used use VBN cord-331343-qzvwwca9 11 15 to to TO cord-331343-qzvwwca9 11 16 discover discover VB cord-331343-qzvwwca9 11 17 the the DT cord-331343-qzvwwca9 11 18 novel novel NN cord-331343-qzvwwca9 11 19 arenavirus arenavirus NNP cord-331343-qzvwwca9 11 20 . . . cord-331343-qzvwwca9 12 1 Their -PRON- PRP$ cord-331343-qzvwwca9 12 2 exhaustive exhaustive JJ cord-331343-qzvwwca9 12 3 search search NN cord-331343-qzvwwca9 12 4 started start VBD cord-331343-qzvwwca9 12 5 with with IN cord-331343-qzvwwca9 12 6 standard standard JJ cord-331343-qzvwwca9 12 7 culture culture NN cord-331343-qzvwwca9 12 8 techniques technique NNS cord-331343-qzvwwca9 12 9 for for IN cord-331343-qzvwwca9 12 10 viruses virus NNS cord-331343-qzvwwca9 12 11 and and CC cord-331343-qzvwwca9 12 12 bacteria bacteria NNS cord-331343-qzvwwca9 12 13 and and CC cord-331343-qzvwwca9 12 14 progressed progress VBD cord-331343-qzvwwca9 12 15 to to IN cord-331343-qzvwwca9 12 16 extensive extensive JJ cord-331343-qzvwwca9 12 17 polymerase polymerase NN cord-331343-qzvwwca9 12 18 chain chain NN cord-331343-qzvwwca9 12 19 reaction reaction NN cord-331343-qzvwwca9 12 20 ( ( -LRB- cord-331343-qzvwwca9 12 21 PCR PCR NNP cord-331343-qzvwwca9 12 22 ) ) -RRB- cord-331343-qzvwwca9 12 23 studies study NNS cord-331343-qzvwwca9 12 24 using use VBG cord-331343-qzvwwca9 12 25 primers primer NNS cord-331343-qzvwwca9 12 26 complementary complementary JJ cord-331343-qzvwwca9 12 27 to to IN cord-331343-qzvwwca9 12 28 over over IN cord-331343-qzvwwca9 12 29 30 30 CD cord-331343-qzvwwca9 12 30 known know VBN cord-331343-qzvwwca9 12 31 viral viral JJ cord-331343-qzvwwca9 12 32 and and CC cord-331343-qzvwwca9 12 33 bacterial bacterial JJ cord-331343-qzvwwca9 12 34 families family NNS cord-331343-qzvwwca9 12 35 . . . cord-331343-qzvwwca9 13 1 1 1 LS cord-331343-qzvwwca9 14 1 The the DT cord-331343-qzvwwca9 14 2 authors author NNS cord-331343-qzvwwca9 14 3 then then RB cord-331343-qzvwwca9 14 4 tried try VBD cord-331343-qzvwwca9 14 5 panmicrobial panmicrobial NNP cord-331343-qzvwwca9 14 6 microarray microarray NNP cord-331343-qzvwwca9 14 7 analysis analysis NN cord-331343-qzvwwca9 14 8 with with IN cord-331343-qzvwwca9 14 9 29,455 29,455 CD cord-331343-qzvwwca9 14 10 oligonucleotide oligonucleotide JJ cord-331343-qzvwwca9 14 11 probes probe NNS cord-331343-qzvwwca9 14 12 reactive reactive JJ cord-331343-qzvwwca9 14 13 to to IN cord-331343-qzvwwca9 14 14 known know VBN cord-331343-qzvwwca9 14 15 vertebrate vertebrate JJ cord-331343-qzvwwca9 14 16 viruses virus NNS cord-331343-qzvwwca9 14 17 , , , cord-331343-qzvwwca9 14 18 bacteria bacteria NNS cord-331343-qzvwwca9 14 19 , , , cord-331343-qzvwwca9 14 20 fungi fungus NNS cord-331343-qzvwwca9 14 21 , , , cord-331343-qzvwwca9 14 22 and and CC cord-331343-qzvwwca9 14 23 parasites parasite NNS cord-331343-qzvwwca9 14 24 , , , cord-331343-qzvwwca9 14 25 5 5 CD cord-331343-qzvwwca9 14 26 and and CC cord-331343-qzvwwca9 14 27 after after IN cord-331343-qzvwwca9 14 28 drawing draw VBG cord-331343-qzvwwca9 14 29 a a DT cord-331343-qzvwwca9 14 30 blank blank NN cord-331343-qzvwwca9 14 31 with with IN cord-331343-qzvwwca9 14 32 all all PDT cord-331343-qzvwwca9 14 33 these these DT cord-331343-qzvwwca9 14 34 studies study NNS cord-331343-qzvwwca9 14 35 , , , cord-331343-qzvwwca9 14 36 they -PRON- PRP cord-331343-qzvwwca9 14 37 resorted resort VBD cord-331343-qzvwwca9 14 38 to to IN cord-331343-qzvwwca9 14 39 brute brute JJ cord-331343-qzvwwca9 14 40 sequencing sequencing NN cord-331343-qzvwwca9 14 41 of of IN cord-331343-qzvwwca9 14 42 all all DT cord-331343-qzvwwca9 14 43 RNA RNA NNP cord-331343-qzvwwca9 14 44 in in IN cord-331343-qzvwwca9 14 45 the the DT cord-331343-qzvwwca9 14 46 infected infected JJ cord-331343-qzvwwca9 14 47 tissue tissue NN cord-331343-qzvwwca9 14 48 to to TO cord-331343-qzvwwca9 14 49 discover discover VB cord-331343-qzvwwca9 14 50 the the DT cord-331343-qzvwwca9 14 51 new new JJ cord-331343-qzvwwca9 14 52 virus virus NN cord-331343-qzvwwca9 14 53 . . . cord-331343-qzvwwca9 15 1 1 1 LS cord-331343-qzvwwca9 16 1 This this DT cord-331343-qzvwwca9 16 2 report report NN cord-331343-qzvwwca9 16 3 brings bring VBZ cord-331343-qzvwwca9 16 4 up up RP cord-331343-qzvwwca9 16 5 important important JJ cord-331343-qzvwwca9 16 6 issues issue NNS cord-331343-qzvwwca9 16 7 concerning concern VBG cord-331343-qzvwwca9 16 8 the the DT cord-331343-qzvwwca9 16 9 role role NN cord-331343-qzvwwca9 16 10 of of IN cord-331343-qzvwwca9 16 11 rodent rodent NN cord-331343-qzvwwca9 16 12 - - HYPH cord-331343-qzvwwca9 16 13 derived derive VBN cord-331343-qzvwwca9 16 14 pathogens pathogen NNS cord-331343-qzvwwca9 16 15 in in IN cord-331343-qzvwwca9 16 16 transplant transplant NN cord-331343-qzvwwca9 16 17 patients patient NNS cord-331343-qzvwwca9 16 18 . . . cord-331343-qzvwwca9 17 1 There there EX cord-331343-qzvwwca9 17 2 is be VBZ cord-331343-qzvwwca9 17 3 also also RB cord-331343-qzvwwca9 17 4 a a DT cord-331343-qzvwwca9 17 5 great great JJ cord-331343-qzvwwca9 17 6 deal deal NN cord-331343-qzvwwca9 17 7 of of IN cord-331343-qzvwwca9 17 8 interest interest NN cord-331343-qzvwwca9 17 9 in in IN cord-331343-qzvwwca9 17 10 the the DT cord-331343-qzvwwca9 17 11 high high JJ cord-331343-qzvwwca9 17 12 - - HYPH cord-331343-qzvwwca9 17 13 throughput throughput NN cord-331343-qzvwwca9 17 14 sequencing sequencing NN cord-331343-qzvwwca9 17 15 methods method NNS cord-331343-qzvwwca9 17 16 that that WDT cord-331343-qzvwwca9 17 17 were be VBD cord-331343-qzvwwca9 17 18 used use VBN cord-331343-qzvwwca9 17 19 to to TO cord-331343-qzvwwca9 17 20 detect detect VB cord-331343-qzvwwca9 17 21 the the DT cord-331343-qzvwwca9 17 22 new new JJ cord-331343-qzvwwca9 17 23 arenavirus arenavirus NN cord-331343-qzvwwca9 17 24 as as RB cord-331343-qzvwwca9 17 25 well well RB cord-331343-qzvwwca9 17 26 as as IN cord-331343-qzvwwca9 17 27 the the DT cord-331343-qzvwwca9 17 28 arrival arrival NN cord-331343-qzvwwca9 17 29 of of IN cord-331343-qzvwwca9 17 30 metagenomics metagenomic NNS cord-331343-qzvwwca9 17 31 as as IN cord-331343-qzvwwca9 17 32 the the DT cord-331343-qzvwwca9 17 33 new new JJ cord-331343-qzvwwca9 17 34 kid kid NN cord-331343-qzvwwca9 17 35 on on IN cord-331343-qzvwwca9 17 36 the the DT cord-331343-qzvwwca9 17 37 block block NN cord-331343-qzvwwca9 17 38 for for IN cord-331343-qzvwwca9 17 39 viral viral JJ cord-331343-qzvwwca9 17 40 discovery discovery NN cord-331343-qzvwwca9 17 41 . . . cord-331343-qzvwwca9 18 1 Metagenomics Metagenomics NNP cord-331343-qzvwwca9 18 2 is be VBZ cord-331343-qzvwwca9 18 3 defined define VBN cord-331343-qzvwwca9 18 4 as as IN cord-331343-qzvwwca9 18 5 the the DT cord-331343-qzvwwca9 18 6 sequenced sequence VBN cord-331343-qzvwwca9 18 7 - - HYPH cord-331343-qzvwwca9 18 8 based base VBN cord-331343-qzvwwca9 18 9 analysis analysis NN cord-331343-qzvwwca9 18 10 of of IN cord-331343-qzvwwca9 18 11 the the DT cord-331343-qzvwwca9 18 12 collective collective JJ cord-331343-qzvwwca9 18 13 microbial microbial JJ cord-331343-qzvwwca9 18 14 genomes genome NNS cord-331343-qzvwwca9 18 15 contained contain VBN cord-331343-qzvwwca9 18 16 in in IN cord-331343-qzvwwca9 18 17 an an DT cord-331343-qzvwwca9 18 18 uncultured uncultured JJ cord-331343-qzvwwca9 18 19 environmental environmental JJ cord-331343-qzvwwca9 18 20 sample sample NN cord-331343-qzvwwca9 18 21 . . . cord-331343-qzvwwca9 19 1 6 6 CD cord-331343-qzvwwca9 20 1 The the DT cord-331343-qzvwwca9 20 2 approach approach NN cord-331343-qzvwwca9 20 3 has have VBZ cord-331343-qzvwwca9 20 4 been be VBN cord-331343-qzvwwca9 20 5 used use VBN cord-331343-qzvwwca9 20 6 for for IN cord-331343-qzvwwca9 20 7 multiple multiple JJ cord-331343-qzvwwca9 20 8 purposes purpose NNS cord-331343-qzvwwca9 20 9 , , , cord-331343-qzvwwca9 20 10 including include VBG cord-331343-qzvwwca9 20 11 the the DT cord-331343-qzvwwca9 20 12 cataloging cataloging NN cord-331343-qzvwwca9 20 13 of of IN cord-331343-qzvwwca9 20 14 ocean ocean NN cord-331343-qzvwwca9 20 15 microbial microbial JJ cord-331343-qzvwwca9 20 16 communities community NNS cord-331343-qzvwwca9 20 17 7 7 CD cord-331343-qzvwwca9 20 18 and and CC cord-331343-qzvwwca9 20 19 the the DT cord-331343-qzvwwca9 20 20 identification identification NN cord-331343-qzvwwca9 20 21 of of IN cord-331343-qzvwwca9 20 22 a a DT cord-331343-qzvwwca9 20 23 viral viral JJ cord-331343-qzvwwca9 20 24 pathogen pathogen NN cord-331343-qzvwwca9 20 25 responsible responsible JJ cord-331343-qzvwwca9 20 26 for for IN cord-331343-qzvwwca9 20 27 honey honey NNP cord-331343-qzvwwca9 20 28 bee bee NNP cord-331343-qzvwwca9 20 29 colony colony NNP cord-331343-qzvwwca9 20 30 collapse collapse NN cord-331343-qzvwwca9 20 31 . . . cord-331343-qzvwwca9 21 1 8 8 CD cord-331343-qzvwwca9 22 1 In in IN cord-331343-qzvwwca9 22 2 humans human NNS cord-331343-qzvwwca9 22 3 , , , cord-331343-qzvwwca9 22 4 metagenomic metagenomic NNP cord-331343-qzvwwca9 22 5 analysis analysis NN cord-331343-qzvwwca9 22 6 has have VBZ cord-331343-qzvwwca9 22 7 been be VBN cord-331343-qzvwwca9 22 8 used use VBN cord-331343-qzvwwca9 22 9 to to TO cord-331343-qzvwwca9 22 10 study study VB cord-331343-qzvwwca9 22 11 viral viral JJ cord-331343-qzvwwca9 22 12 communities community NNS cord-331343-qzvwwca9 22 13 in in IN cord-331343-qzvwwca9 22 14 blood blood NN cord-331343-qzvwwca9 22 15 and and CC cord-331343-qzvwwca9 22 16 respiratory respiratory JJ cord-331343-qzvwwca9 22 17 secretions secretion NNS cord-331343-qzvwwca9 22 18 , , , cord-331343-qzvwwca9 22 19 6 6 CD cord-331343-qzvwwca9 22 20 to to TO cord-331343-qzvwwca9 22 21 differentiate differentiate VB cord-331343-qzvwwca9 22 22 bacterial bacterial JJ cord-331343-qzvwwca9 22 23 species specie NNS cord-331343-qzvwwca9 22 24 in in IN cord-331343-qzvwwca9 22 25 gut gut NN cord-331343-qzvwwca9 22 26 flora flora NNS cord-331343-qzvwwca9 22 27 , , , cord-331343-qzvwwca9 22 28 9 9 CD cord-331343-qzvwwca9 22 29 and and CC cord-331343-qzvwwca9 22 30 to to TO cord-331343-qzvwwca9 22 31 catalog catalog VB cord-331343-qzvwwca9 22 32 the the DT cord-331343-qzvwwca9 22 33 collective collective JJ cord-331343-qzvwwca9 22 34 DNA DNA NNP cord-331343-qzvwwca9 22 35 and and CC cord-331343-qzvwwca9 22 36 RNA RNA NNP cord-331343-qzvwwca9 22 37 viral viral JJ cord-331343-qzvwwca9 22 38 species specie NNS cord-331343-qzvwwca9 22 39 in in IN cord-331343-qzvwwca9 22 40 stool stool NN cord-331343-qzvwwca9 22 41 samples sample NNS cord-331343-qzvwwca9 22 42 of of IN cord-331343-qzvwwca9 22 43 healthy healthy JJ cord-331343-qzvwwca9 22 44 subjects subject NNS cord-331343-qzvwwca9 22 45 10 10 CD cord-331343-qzvwwca9 22 46 , , , cord-331343-qzvwwca9 22 47 11 11 CD cord-331343-qzvwwca9 22 48 and and CC cord-331343-qzvwwca9 22 49 patients patient NNS cord-331343-qzvwwca9 22 50 with with IN cord-331343-qzvwwca9 22 51 diarrhea diarrhea NN cord-331343-qzvwwca9 22 52 . . . cord-331343-qzvwwca9 23 1 12 12 CD cord-331343-qzvwwca9 23 2 American american JJ cord-331343-qzvwwca9 23 3 , , , cord-331343-qzvwwca9 23 4 European european JJ cord-331343-qzvwwca9 23 5 , , , cord-331343-qzvwwca9 23 6 and and CC cord-331343-qzvwwca9 23 7 Asian asian JJ cord-331343-qzvwwca9 23 8 consortia consortium NNS cord-331343-qzvwwca9 23 9 are be VBP cord-331343-qzvwwca9 23 10 now now RB cord-331343-qzvwwca9 23 11 aligned align VBN cord-331343-qzvwwca9 23 12 to to TO cord-331343-qzvwwca9 23 13 conduct conduct VB cord-331343-qzvwwca9 23 14 studies study NNS cord-331343-qzvwwca9 23 15 in in IN cord-331343-qzvwwca9 23 16 humans human NNS cord-331343-qzvwwca9 23 17 focused focus VBD cord-331343-qzvwwca9 23 18 on on IN cord-331343-qzvwwca9 23 19 bacteria bacteria NNS cord-331343-qzvwwca9 23 20 in in IN cord-331343-qzvwwca9 23 21 the the DT cord-331343-qzvwwca9 23 22 gut gut NN cord-331343-qzvwwca9 23 23 and and CC cord-331343-qzvwwca9 23 24 other other JJ cord-331343-qzvwwca9 23 25 body body NN cord-331343-qzvwwca9 23 26 cavities cavity NNS cord-331343-qzvwwca9 23 27 , , , cord-331343-qzvwwca9 23 28 13 13 CD cord-331343-qzvwwca9 23 29 and and CC cord-331343-qzvwwca9 23 30 metagenomics metagenomic NNS cord-331343-qzvwwca9 23 31 has have VBZ cord-331343-qzvwwca9 23 32 emerged emerge VBN cord-331343-qzvwwca9 23 33 as as IN cord-331343-qzvwwca9 23 34 the the DT cord-331343-qzvwwca9 23 35 methodology methodology NN cord-331343-qzvwwca9 23 36 of of IN cord-331343-qzvwwca9 23 37 choice choice NN cord-331343-qzvwwca9 23 38 for for IN cord-331343-qzvwwca9 23 39 virus virus NN cord-331343-qzvwwca9 23 40 discovery discovery NN cord-331343-qzvwwca9 23 41 in in IN cord-331343-qzvwwca9 23 42 humans human NNS cord-331343-qzvwwca9 23 43 over over IN cord-331343-qzvwwca9 23 44 the the DT cord-331343-qzvwwca9 23 45 last last JJ cord-331343-qzvwwca9 23 46 year year NN cord-331343-qzvwwca9 23 47 . . . cord-331343-qzvwwca9 24 1 12 12 CD cord-331343-qzvwwca9 24 2 , , , cord-331343-qzvwwca9 24 3 14 14 CD cord-331343-qzvwwca9 25 1 For for IN cord-331343-qzvwwca9 25 2 example example NN cord-331343-qzvwwca9 25 3 , , , cord-331343-qzvwwca9 25 4 Merkel Merkel NNP cord-331343-qzvwwca9 25 5 cell cell NN cord-331343-qzvwwca9 25 6 carcinoma carcinoma NN cord-331343-qzvwwca9 25 7 is be VBZ cord-331343-qzvwwca9 25 8 found find VBN cord-331343-qzvwwca9 25 9 in in IN cord-331343-qzvwwca9 25 10 immunosuppressed immunosuppressed JJ cord-331343-qzvwwca9 25 11 individuals individual NNS cord-331343-qzvwwca9 25 12 , , , cord-331343-qzvwwca9 25 13 and and CC cord-331343-qzvwwca9 25 14 this this DT cord-331343-qzvwwca9 25 15 suggests suggest VBZ cord-331343-qzvwwca9 25 16 an an DT cord-331343-qzvwwca9 25 17 infectious infectious JJ cord-331343-qzvwwca9 25 18 etiology etiology NN cord-331343-qzvwwca9 25 19 . . . cord-331343-qzvwwca9 26 1 Therefore therefore RB cord-331343-qzvwwca9 26 2 , , , cord-331343-qzvwwca9 26 3 investigators investigator NNS cord-331343-qzvwwca9 26 4 at at IN cord-331343-qzvwwca9 26 5 the the DT cord-331343-qzvwwca9 26 6 University University NNP cord-331343-qzvwwca9 26 7 of of IN cord-331343-qzvwwca9 26 8 Pittsburgh Pittsburgh NNP cord-331343-qzvwwca9 26 9 sequenced sequence VBD cord-331343-qzvwwca9 26 10 ϳ380,000 ϳ380,000 NNP cord-331343-qzvwwca9 26 11 transcripts transcript NNS cord-331343-qzvwwca9 26 12 extracted extract VBN cord-331343-qzvwwca9 26 13 from from IN cord-331343-qzvwwca9 26 14 the the DT cord-331343-qzvwwca9 26 15 rare rare JJ cord-331343-qzvwwca9 26 16 skin skin NN cord-331343-qzvwwca9 26 17 cancer cancer NN cord-331343-qzvwwca9 26 18 . . . cord-331343-qzvwwca9 27 1 14 14 CD cord-331343-qzvwwca9 28 1 After after IN cord-331343-qzvwwca9 28 2 biocomputational biocomputational JJ cord-331343-qzvwwca9 28 3 processing processing NN cord-331343-qzvwwca9 28 4 , , , cord-331343-qzvwwca9 28 5 2 2 CD cord-331343-qzvwwca9 28 6 of of IN cord-331343-qzvwwca9 28 7 the the DT cord-331343-qzvwwca9 28 8 ϳ2400 ϳ2400 JJ cord-331343-qzvwwca9 28 9 nonhuman nonhuman NN cord-331343-qzvwwca9 28 10 sequences sequence NNS cord-331343-qzvwwca9 28 11 were be VBD cord-331343-qzvwwca9 28 12 found find VBN cord-331343-qzvwwca9 28 13 to to TO cord-331343-qzvwwca9 28 14 share share VB cord-331343-qzvwwca9 28 15 homology homology NN cord-331343-qzvwwca9 28 16 with with IN cord-331343-qzvwwca9 28 17 polyomaviruses polyomaviruse NNS cord-331343-qzvwwca9 28 18 . . . cord-331343-qzvwwca9 29 1 Subsequently subsequently RB cord-331343-qzvwwca9 29 2 , , , cord-331343-qzvwwca9 29 3 sequences sequence NNS cord-331343-qzvwwca9 29 4 from from IN cord-331343-qzvwwca9 29 5 the the DT cord-331343-qzvwwca9 29 6 newly newly RB cord-331343-qzvwwca9 29 7 identified identify VBN cord-331343-qzvwwca9 29 8 Merkel Merkel NNP cord-331343-qzvwwca9 29 9 cell cell NN cord-331343-qzvwwca9 29 10 polyomavirus polyomavirus NNP cord-331343-qzvwwca9 29 11 were be VBD cord-331343-qzvwwca9 29 12 detected detect VBN cord-331343-qzvwwca9 29 13 in in IN cord-331343-qzvwwca9 29 14 80 80 CD cord-331343-qzvwwca9 29 15 % % NN cord-331343-qzvwwca9 29 16 of of IN cord-331343-qzvwwca9 29 17 tumor tumor NN cord-331343-qzvwwca9 29 18 samples sample NNS cord-331343-qzvwwca9 29 19 and and CC cord-331343-qzvwwca9 29 20 5 5 CD cord-331343-qzvwwca9 29 21 % % NN cord-331343-qzvwwca9 29 22 of of IN cord-331343-qzvwwca9 29 23 controls control NNS cord-331343-qzvwwca9 29 24 . . . cord-331343-qzvwwca9 30 1 14 14 CD cord-331343-qzvwwca9 31 1 In in IN cord-331343-qzvwwca9 31 2 essence essence NN cord-331343-qzvwwca9 31 3 , , , cord-331343-qzvwwca9 31 4 the the DT cord-331343-qzvwwca9 31 5 number number NN cord-331343-qzvwwca9 31 6 needed need VBN cord-331343-qzvwwca9 31 7 to to TO cord-331343-qzvwwca9 31 8 sequence sequence VB cord-331343-qzvwwca9 31 9 ( ( -LRB- cord-331343-qzvwwca9 31 10 NNS NNS NNP cord-331343-qzvwwca9 31 11 ) ) -RRB- cord-331343-qzvwwca9 31 12 in in IN cord-331343-qzvwwca9 31 13 order order NN cord-331343-qzvwwca9 31 14 to to TO cord-331343-qzvwwca9 31 15 discover discover VB cord-331343-qzvwwca9 31 16 the the DT cord-331343-qzvwwca9 31 17 novel novel JJ cord-331343-qzvwwca9 31 18 Merkel Merkel NNP cord-331343-qzvwwca9 31 19 cell cell NN cord-331343-qzvwwca9 31 20 polyomavirus polyomavirus NNP cord-331343-qzvwwca9 31 21 was be VBD cord-331343-qzvwwca9 31 22 1/190,000 1/190,000 CD cord-331343-qzvwwca9 31 23 , , , cord-331343-qzvwwca9 31 24 which which WDT cord-331343-qzvwwca9 31 25 appears appear VBZ cord-331343-qzvwwca9 31 26 cost cost NN cord-331343-qzvwwca9 31 27 - - HYPH cord-331343-qzvwwca9 31 28 prohibitive prohibitive JJ cord-331343-qzvwwca9 31 29 for for IN cord-331343-qzvwwca9 31 30 current current JJ cord-331343-qzvwwca9 31 31 capillary capillary JJ cord-331343-qzvwwca9 31 32 sequencing sequencing NN cord-331343-qzvwwca9 31 33 . . . cord-331343-qzvwwca9 32 1 In in IN cord-331343-qzvwwca9 32 2 contrast contrast NN cord-331343-qzvwwca9 32 3 , , , cord-331343-qzvwwca9 32 4 Palacios Palacios NNP cord-331343-qzvwwca9 32 5 and and CC cord-331343-qzvwwca9 32 6 colleagues colleague NNS cord-331343-qzvwwca9 32 7 1 1 CD cord-331343-qzvwwca9 32 8 sequenced sequence VBN cord-331343-qzvwwca9 32 9 ϳ94,000 ϳ94,000 IN cord-331343-qzvwwca9 32 10 transcripts transcript NNS cord-331343-qzvwwca9 32 11 from from IN cord-331343-qzvwwca9 32 12 infected infected JJ cord-331343-qzvwwca9 32 13 allografts allograft NNS cord-331343-qzvwwca9 32 14 and and CC cord-331343-qzvwwca9 32 15 found find VBD cord-331343-qzvwwca9 32 16 14 14 CD cord-331343-qzvwwca9 32 17 sequences sequence NNS cord-331343-qzvwwca9 32 18 that that WDT cord-331343-qzvwwca9 32 19 resembled resemble VBD cord-331343-qzvwwca9 32 20 an an DT cord-331343-qzvwwca9 32 21 Old Old NNP cord-331343-qzvwwca9 32 22 World World NNP cord-331343-qzvwwca9 32 23 arenavirus arenavirus NN cord-331343-qzvwwca9 32 24 , , , cord-331343-qzvwwca9 32 25 providing provide VBG cord-331343-qzvwwca9 32 26 an an DT cord-331343-qzvwwca9 32 27 NNS nns NN cord-331343-qzvwwca9 32 28 of of IN cord-331343-qzvwwca9 32 29 approximately approximately RB cord-331343-qzvwwca9 32 30 1/6700 1/6700 CD cord-331343-qzvwwca9 32 31 for for IN cord-331343-qzvwwca9 32 32 their -PRON- PRP$ cord-331343-qzvwwca9 32 33 viral viral JJ cord-331343-qzvwwca9 32 34 agent agent NN cord-331343-qzvwwca9 32 35 . . . cord-331343-qzvwwca9 33 1 Both both DT cord-331343-qzvwwca9 33 2 groups group NNS cord-331343-qzvwwca9 33 3 used use VBD cord-331343-qzvwwca9 33 4 highthroughput highthroughput NN cord-331343-qzvwwca9 33 5 pyrosequencing pyrosequencing NN cord-331343-qzvwwca9 33 6 , , , cord-331343-qzvwwca9 33 7 which which WDT cord-331343-qzvwwca9 33 8 is be VBZ cord-331343-qzvwwca9 33 9 far far RB cord-331343-qzvwwca9 33 10 cheaper cheap JJR cord-331343-qzvwwca9 33 11 than than IN cord-331343-qzvwwca9 33 12 capillary capillary JJ cord-331343-qzvwwca9 33 13 sequencing sequencing NN cord-331343-qzvwwca9 33 14 ( ( -LRB- cord-331343-qzvwwca9 33 15 Fig Fig NNP cord-331343-qzvwwca9 33 16 . . . cord-331343-qzvwwca9 33 17 1 1 CD cord-331343-qzvwwca9 33 18 ) ) -RRB- cord-331343-qzvwwca9 33 19 . . . cord-331343-qzvwwca9 34 1 Will Will MD cord-331343-qzvwwca9 34 2 the the DT cord-331343-qzvwwca9 34 3 brute brute JJ cord-331343-qzvwwca9 34 4 - - HYPH cord-331343-qzvwwca9 34 5 force force NN cord-331343-qzvwwca9 34 6 approach approach NN cord-331343-qzvwwca9 34 7 of of IN cord-331343-qzvwwca9 34 8 high high JJ cord-331343-qzvwwca9 34 9 - - HYPH cord-331343-qzvwwca9 34 10 throughput throughput NN cord-331343-qzvwwca9 34 11 sequencing sequencing NN cord-331343-qzvwwca9 34 12 catch catch NN cord-331343-qzvwwca9 34 13 on on RP cord-331343-qzvwwca9 34 14 for for IN cord-331343-qzvwwca9 34 15 virus virus NN cord-331343-qzvwwca9 34 16 discovery discovery NN cord-331343-qzvwwca9 34 17 ? ? . cord-331343-qzvwwca9 35 1 The the DT cord-331343-qzvwwca9 35 2 answer answer NN cord-331343-qzvwwca9 35 3 is be VBZ cord-331343-qzvwwca9 35 4 undoubtedly undoubtedly RB cord-331343-qzvwwca9 35 5 yes yes UH cord-331343-qzvwwca9 35 6 . . . cord-331343-qzvwwca9 36 1 The the DT cord-331343-qzvwwca9 36 2 process process NN cord-331343-qzvwwca9 36 3 is be VBZ cord-331343-qzvwwca9 36 4 unbiased unbiased JJ cord-331343-qzvwwca9 36 5 , , , cord-331343-qzvwwca9 36 6 relatively relatively RB cord-331343-qzvwwca9 36 7 insensitive insensitive JJ cord-331343-qzvwwca9 36 8 to to IN cord-331343-qzvwwca9 36 9 a a DT cord-331343-qzvwwca9 36 10 low low JJ cord-331343-qzvwwca9 36 11 copy copy NN cord-331343-qzvwwca9 36 12 number number NN cord-331343-qzvwwca9 36 13 , , , cord-331343-qzvwwca9 36 14 lacks lack VBZ cord-331343-qzvwwca9 36 15 the the DT cord-331343-qzvwwca9 36 16 inherent inherent JJ cord-331343-qzvwwca9 36 17 problem problem NN cord-331343-qzvwwca9 36 18 with with IN cord-331343-qzvwwca9 36 19 PCR PCR NNP cord-331343-qzvwwca9 36 20 of of IN cord-331343-qzvwwca9 36 21 widespread widespread JJ cord-331343-qzvwwca9 36 22 contamination contamination NN cord-331343-qzvwwca9 36 23 , , , cord-331343-qzvwwca9 36 24 and and CC cord-331343-qzvwwca9 36 25 has have VBZ cord-331343-qzvwwca9 36 26 the the DT cord-331343-qzvwwca9 36 27 potential potential NN cord-331343-qzvwwca9 36 28 to to TO cord-331343-qzvwwca9 36 29 provide provide VB cord-331343-qzvwwca9 36 30 a a DT cord-331343-qzvwwca9 36 31 complete complete JJ cord-331343-qzvwwca9 36 32 representation representation NN cord-331343-qzvwwca9 36 33 of of IN cord-331343-qzvwwca9 36 34 all all DT cord-331343-qzvwwca9 36 35 viruses virus NNS cord-331343-qzvwwca9 36 36 within within IN cord-331343-qzvwwca9 36 37 the the DT cord-331343-qzvwwca9 36 38 environment environment NN cord-331343-qzvwwca9 36 39 . . . cord-331343-qzvwwca9 37 1 15 15 CD cord-331343-qzvwwca9 38 1 On on IN cord-331343-qzvwwca9 38 2 reflection reflection NN cord-331343-qzvwwca9 38 3 , , , cord-331343-qzvwwca9 38 4 even even RB cord-331343-qzvwwca9 38 5 Houghton Houghton NNP cord-331343-qzvwwca9 38 6 's 's POS cord-331343-qzvwwca9 38 7 team team NN cord-331343-qzvwwca9 38 8 , , , cord-331343-qzvwwca9 38 9 cloning clone VBG cord-331343-qzvwwca9 38 10 hepatitis hepatitis NN cord-331343-qzvwwca9 38 11 C C NNP cord-331343-qzvwwca9 38 12 virus virus NN cord-331343-qzvwwca9 38 13 ( ( -LRB- cord-331343-qzvwwca9 38 14 HCV HCV NNP cord-331343-qzvwwca9 38 15 ) ) -RRB- cord-331343-qzvwwca9 38 16 with with IN cord-331343-qzvwwca9 38 17 state state NN cord-331343-qzvwwca9 38 18 - - HYPH cord-331343-qzvwwca9 38 19 of of IN cord-331343-qzvwwca9 38 20 - - HYPH cord-331343-qzvwwca9 38 21 the the DT cord-331343-qzvwwca9 38 22 - - HYPH cord-331343-qzvwwca9 38 23 art art NN cord-331343-qzvwwca9 38 24 molecular molecular JJ cord-331343-qzvwwca9 38 25 complementary complementary JJ cord-331343-qzvwwca9 38 26 DNA dna NN cord-331343-qzvwwca9 38 27 cloning cloning NN cord-331343-qzvwwca9 38 28 techniques technique NNS cord-331343-qzvwwca9 38 29 in in IN cord-331343-qzvwwca9 38 30 the the DT cord-331343-qzvwwca9 38 31 1980s 1980 NNS cord-331343-qzvwwca9 38 32 , , , cord-331343-qzvwwca9 38 33 eventually eventually RB cord-331343-qzvwwca9 38 34 had have VBD cord-331343-qzvwwca9 38 35 to to TO cord-331343-qzvwwca9 38 36 screen screen VB cord-331343-qzvwwca9 38 37 more more JJR cord-331343-qzvwwca9 38 38 than than IN cord-331343-qzvwwca9 38 39 20 20 CD cord-331343-qzvwwca9 38 40 million million CD cord-331343-qzvwwca9 38 41 individual individual JJ cord-331343-qzvwwca9 38 42 clones clone NNS cord-331343-qzvwwca9 38 43 before before IN cord-331343-qzvwwca9 38 44 they -PRON- PRP cord-331343-qzvwwca9 38 45 finally finally RB cord-331343-qzvwwca9 38 46 identified identify VBD cord-331343-qzvwwca9 38 47 a a DT cord-331343-qzvwwca9 38 48 gene gene NN cord-331343-qzvwwca9 38 49 product product NN cord-331343-qzvwwca9 38 50 reactive reactive JJ cord-331343-qzvwwca9 38 51 to to IN cord-331343-qzvwwca9 38 52 anti anti JJ cord-331343-qzvwwca9 38 53 - - JJ cord-331343-qzvwwca9 38 54 HCV HCV NNP cord-331343-qzvwwca9 38 55 . . . cord-331343-qzvwwca9 39 1 16 16 CD cord-331343-qzvwwca9 40 1 They -PRON- PRP cord-331343-qzvwwca9 40 2 would would MD cord-331343-qzvwwca9 40 3 have have VB cord-331343-qzvwwca9 40 4 saved save VBN cord-331343-qzvwwca9 40 5 a a DT cord-331343-qzvwwca9 40 6 considerable considerable JJ cord-331343-qzvwwca9 40 7 amount amount NN cord-331343-qzvwwca9 40 8 of of IN cord-331343-qzvwwca9 40 9 time time NN cord-331343-qzvwwca9 40 10 and and CC cord-331343-qzvwwca9 40 11 effort effort NN cord-331343-qzvwwca9 40 12 if if IN cord-331343-qzvwwca9 40 13 they -PRON- PRP cord-331343-qzvwwca9 40 14 could could MD cord-331343-qzvwwca9 40 15 have have VB cord-331343-qzvwwca9 40 16 sequenced sequence VBN cord-331343-qzvwwca9 40 17 RNA RNA NNP cord-331343-qzvwwca9 40 18 from from IN cord-331343-qzvwwca9 40 19 a a DT cord-331343-qzvwwca9 40 20 few few JJ cord-331343-qzvwwca9 40 21 " " `` cord-331343-qzvwwca9 40 22 non non JJ cord-331343-qzvwwca9 40 23 - - JJ cord-331343-qzvwwca9 40 24 A a JJ cord-331343-qzvwwca9 40 25 non non JJ cord-331343-qzvwwca9 40 26 - - JJ cord-331343-qzvwwca9 40 27 B b JJ cord-331343-qzvwwca9 40 28 virus virus NN cord-331343-qzvwwca9 40 29 " " `` cord-331343-qzvwwca9 40 30 infected infect VBN cord-331343-qzvwwca9 40 31 livers liver NNS cord-331343-qzvwwca9 40 32 ( ( -LRB- cord-331343-qzvwwca9 40 33 assuming assume VBG cord-331343-qzvwwca9 40 34 that that IN cord-331343-qzvwwca9 40 35 they -PRON- PRP cord-331343-qzvwwca9 40 36 could could MD cord-331343-qzvwwca9 40 37 have have VB cord-331343-qzvwwca9 40 38 had have VBD cord-331343-qzvwwca9 40 39 access access NN cord-331343-qzvwwca9 40 40 to to IN cord-331343-qzvwwca9 40 41 human human JJ cord-331343-qzvwwca9 40 42 genome genome NN cord-331343-qzvwwca9 40 43 data datum NNS cord-331343-qzvwwca9 40 44 that that WDT cord-331343-qzvwwca9 40 45 were be VBD cord-331343-qzvwwca9 40 46 not not RB cord-331343-qzvwwca9 40 47 available available JJ cord-331343-qzvwwca9 40 48 at at IN cord-331343-qzvwwca9 40 49 the the DT cord-331343-qzvwwca9 40 50 time time NN cord-331343-qzvwwca9 40 51 ) ) -RRB- cord-331343-qzvwwca9 40 52 . . . cord-331343-qzvwwca9 41 1 However however RB cord-331343-qzvwwca9 41 2 , , , cord-331343-qzvwwca9 41 3 there there EX cord-331343-qzvwwca9 41 4 are be VBP cord-331343-qzvwwca9 41 5 additional additional JJ cord-331343-qzvwwca9 41 6 considerations consideration NNS cord-331343-qzvwwca9 41 7 , , , cord-331343-qzvwwca9 41 8 such such JJ cord-331343-qzvwwca9 41 9 as as IN cord-331343-qzvwwca9 41 10 the the DT cord-331343-qzvwwca9 41 11 copy copy NN cord-331343-qzvwwca9 41 12 number number NN cord-331343-qzvwwca9 41 13 of of IN cord-331343-qzvwwca9 41 14 the the DT cord-331343-qzvwwca9 41 15 virus virus NN cord-331343-qzvwwca9 41 16 in in IN cord-331343-qzvwwca9 41 17 infected infected JJ cord-331343-qzvwwca9 41 18 liver liver NN cord-331343-qzvwwca9 41 19 samples sample NNS cord-331343-qzvwwca9 41 20 and and CC cord-331343-qzvwwca9 41 21 the the DT cord-331343-qzvwwca9 41 22 predicted predict VBN cord-331343-qzvwwca9 41 23 NNS NNS NNP cord-331343-qzvwwca9 41 24 required require VBD cord-331343-qzvwwca9 41 25 to to TO cord-331343-qzvwwca9 41 26 detect detect VB cord-331343-qzvwwca9 41 27 the the DT cord-331343-qzvwwca9 41 28 agent agent NN cord-331343-qzvwwca9 41 29 . . . cord-331343-qzvwwca9 42 1 Clearly clearly RB cord-331343-qzvwwca9 42 2 , , , cord-331343-qzvwwca9 42 3 the the DT cord-331343-qzvwwca9 42 4 other other JJ cord-331343-qzvwwca9 42 5 major major JJ cord-331343-qzvwwca9 42 6 issue issue NN cord-331343-qzvwwca9 42 7 with with IN cord-331343-qzvwwca9 42 8 metagenomics metagenomic NNS cord-331343-qzvwwca9 42 9 is be VBZ cord-331343-qzvwwca9 42 10 the the DT cord-331343-qzvwwca9 42 11 cost cost NN cord-331343-qzvwwca9 42 12 . . . cord-331343-qzvwwca9 43 1 With with IN cord-331343-qzvwwca9 43 2 the the DT cord-331343-qzvwwca9 43 3 marked marked JJ cord-331343-qzvwwca9 43 4 reduction reduction NN cord-331343-qzvwwca9 43 5 of of IN cord-331343-qzvwwca9 43 6 sequencing sequencing NN cord-331343-qzvwwca9 43 7 costs cost NNS cord-331343-qzvwwca9 43 8 predicted predict VBN cord-331343-qzvwwca9 43 9 in in IN cord-331343-qzvwwca9 43 10 the the DT cord-331343-qzvwwca9 43 11 near near JJ cord-331343-qzvwwca9 43 12 future future NN cord-331343-qzvwwca9 43 13 , , , cord-331343-qzvwwca9 43 14 high high JJ cord-331343-qzvwwca9 43 15 - - HYPH cord-331343-qzvwwca9 43 16 throughput throughput NN cord-331343-qzvwwca9 43 17 sequencing sequencing NN cord-331343-qzvwwca9 43 18 will will MD cord-331343-qzvwwca9 43 19 become become VB cord-331343-qzvwwca9 43 20 more more RBR cord-331343-qzvwwca9 43 21 popular popular JJ cord-331343-qzvwwca9 43 22 . . . cord-331343-qzvwwca9 44 1 Ironically ironically RB cord-331343-qzvwwca9 44 2 , , , cord-331343-qzvwwca9 44 3 most most JJS cord-331343-qzvwwca9 44 4 of of IN cord-331343-qzvwwca9 44 5 this this DT cord-331343-qzvwwca9 44 6 technology technology NN cord-331343-qzvwwca9 44 7 development development NN cord-331343-qzvwwca9 44 8 is be VBZ cord-331343-qzvwwca9 44 9 being be VBG cord-331343-qzvwwca9 44 10 driven drive VBN cord-331343-qzvwwca9 44 11 by by IN cord-331343-qzvwwca9 44 12 the the DT cord-331343-qzvwwca9 44 13 global global JJ cord-331343-qzvwwca9 44 14 efforts effort NNS cord-331343-qzvwwca9 44 15 to to TO cord-331343-qzvwwca9 44 16 identify identify VB cord-331343-qzvwwca9 44 17 genetic genetic JJ cord-331343-qzvwwca9 44 18 determinants determinant NNS cord-331343-qzvwwca9 44 19 of of IN cord-331343-qzvwwca9 44 20 human human JJ cord-331343-qzvwwca9 44 21 disease disease NN cord-331343-qzvwwca9 44 22 . . . cord-331343-qzvwwca9 45 1 17 17 CD cord-331343-qzvwwca9 46 1 An an DT cord-331343-qzvwwca9 46 2 international international JJ cord-331343-qzvwwca9 46 3 consortium consortium NN cord-331343-qzvwwca9 46 4 of of IN cord-331343-qzvwwca9 46 5 American american JJ cord-331343-qzvwwca9 46 6 , , , cord-331343-qzvwwca9 46 7 British british JJ cord-331343-qzvwwca9 46 8 , , , cord-331343-qzvwwca9 46 9 and and CC cord-331343-qzvwwca9 46 10 Chinese chinese JJ cord-331343-qzvwwca9 46 11 researchers researcher NNS cord-331343-qzvwwca9 46 12 is be VBZ cord-331343-qzvwwca9 46 13 promising promise VBG cord-331343-qzvwwca9 46 14 to to TO cord-331343-qzvwwca9 46 15 sequence sequence VB cord-331343-qzvwwca9 46 16 1000 1000 CD cord-331343-qzvwwca9 46 17 human human JJ cord-331343-qzvwwca9 46 18 genomes genome NNS cord-331343-qzvwwca9 46 19 in in IN cord-331343-qzvwwca9 46 20 the the DT cord-331343-qzvwwca9 46 21 next next JJ cord-331343-qzvwwca9 46 22 3 3 CD cord-331343-qzvwwca9 46 23 years year NNS cord-331343-qzvwwca9 46 24 . . . cord-331343-qzvwwca9 47 1 18 18 CD cord-331343-qzvwwca9 48 1 To to TO cord-331343-qzvwwca9 48 2 put put VB cord-331343-qzvwwca9 48 3 these these DT cord-331343-qzvwwca9 48 4 developments development NNS cord-331343-qzvwwca9 48 5 in in IN cord-331343-qzvwwca9 48 6 perspective perspective NN cord-331343-qzvwwca9 48 7 , , , cord-331343-qzvwwca9 48 8 when when WRB cord-331343-qzvwwca9 48 9 one one CD cord-331343-qzvwwca9 48 10 of of IN cord-331343-qzvwwca9 48 11 us -PRON- PRP cord-331343-qzvwwca9 48 12 ( ( -LRB- cord-331343-qzvwwca9 48 13 G.K.-S.W. G.K.-S.W. NNP cord-331343-qzvwwca9 48 14 ) ) -RRB- cord-331343-qzvwwca9 48 15 sequenced sequence VBD cord-331343-qzvwwca9 48 16 the the DT cord-331343-qzvwwca9 48 17 rice rice NN cord-331343-qzvwwca9 48 18 genome genome NN cord-331343-qzvwwca9 48 19 in in IN cord-331343-qzvwwca9 48 20 2002 2002 CD cord-331343-qzvwwca9 48 21 , , , cord-331343-qzvwwca9 48 22 19 19 CD cord-331343-qzvwwca9 48 23 most most JJS cord-331343-qzvwwca9 48 24 of of IN cord-331343-qzvwwca9 48 25 the the DT cord-331343-qzvwwca9 48 26 major major JJ cord-331343-qzvwwca9 48 27 genome genome NN cord-331343-qzvwwca9 48 28 centers center NNS cord-331343-qzvwwca9 48 29 were be VBD cord-331343-qzvwwca9 48 30 producing produce VBG cord-331343-qzvwwca9 48 31 high high JJ cord-331343-qzvwwca9 48 32 - - HYPH cord-331343-qzvwwca9 48 33 quality quality NN cord-331343-qzvwwca9 48 34 " " '' cord-331343-qzvwwca9 48 35 finished finish VBD cord-331343-qzvwwca9 48 36 " " '' cord-331343-qzvwwca9 48 37 sequences sequence NNS cord-331343-qzvwwca9 48 38 at at IN cord-331343-qzvwwca9 48 39 $ $ $ cord-331343-qzvwwca9 48 40 0.10 0.10 CD cord-331343-qzvwwca9 48 41 per per IN cord-331343-qzvwwca9 48 42 base base NN cord-331343-qzvwwca9 48 43 pair pair NN cord-331343-qzvwwca9 48 44 . . . cord-331343-qzvwwca9 49 1 With with IN cord-331343-qzvwwca9 49 2 the the DT cord-331343-qzvwwca9 49 3 latest late JJS cord-331343-qzvwwca9 49 4 technologies technology NNS cord-331343-qzvwwca9 49 5 , , , cord-331343-qzvwwca9 49 6 however however RB cord-331343-qzvwwca9 49 7 , , , cord-331343-qzvwwca9 49 8 a a DT cord-331343-qzvwwca9 49 9 similar similar JJ cord-331343-qzvwwca9 49 10 product product NN cord-331343-qzvwwca9 49 11 can can MD cord-331343-qzvwwca9 49 12 now now RB cord-331343-qzvwwca9 49 13 be be VB cord-331343-qzvwwca9 49 14 created create VBN cord-331343-qzvwwca9 49 15 for for IN cord-331343-qzvwwca9 49 16 approximately approximately RB cord-331343-qzvwwca9 49 17 $ $ $ cord-331343-qzvwwca9 49 18 0.001 0.001 CD cord-331343-qzvwwca9 49 19 per per IN cord-331343-qzvwwca9 49 20 base base NN cord-331343-qzvwwca9 49 21 pair pair NN cord-331343-qzvwwca9 49 22 . . . cord-331343-qzvwwca9 50 1 The the DT cord-331343-qzvwwca9 50 2 new new JJ cord-331343-qzvwwca9 50 3 instruments instrument NNS cord-331343-qzvwwca9 50 4 are be VBP cord-331343-qzvwwca9 50 5 quite quite RB cord-331343-qzvwwca9 50 6 different different JJ cord-331343-qzvwwca9 50 7 from from IN cord-331343-qzvwwca9 50 8 the the DT cord-331343-qzvwwca9 50 9 ones one NNS cord-331343-qzvwwca9 50 10 used use VBN cord-331343-qzvwwca9 50 11 by by IN cord-331343-qzvwwca9 50 12 the the DT cord-331343-qzvwwca9 50 13 original original JJ cord-331343-qzvwwca9 50 14 human human JJ cord-331343-qzvwwca9 50 15 genome genome NN cord-331343-qzvwwca9 50 16 project project NN cord-331343-qzvwwca9 50 17 , , , cord-331343-qzvwwca9 50 18 insofar insofar RB cord-331343-qzvwwca9 50 19 as as IN cord-331343-qzvwwca9 50 20 they -PRON- PRP cord-331343-qzvwwca9 50 21 do do VBP cord-331343-qzvwwca9 50 22 not not RB cord-331343-qzvwwca9 50 23 use use VB cord-331343-qzvwwca9 50 24 electrophoresis electrophoresis NN cord-331343-qzvwwca9 50 25 to to TO cord-331343-qzvwwca9 50 26 separate separate VB cord-331343-qzvwwca9 50 27 the the DT cord-331343-qzvwwca9 50 28 DNA dna NN cord-331343-qzvwwca9 50 29 molecules molecule NNS cord-331343-qzvwwca9 50 30 . . . cord-331343-qzvwwca9 51 1 Instead instead RB cord-331343-qzvwwca9 51 2 , , , cord-331343-qzvwwca9 51 3 they -PRON- PRP cord-331343-qzvwwca9 51 4 capture capture VBP cord-331343-qzvwwca9 51 5 single single JJ cord-331343-qzvwwca9 51 6 DNA dna NN cord-331343-qzvwwca9 51 7 molecules molecule NNS cord-331343-qzvwwca9 51 8 on on IN cord-331343-qzvwwca9 51 9 a a DT cord-331343-qzvwwca9 51 10 solid solid JJ cord-331343-qzvwwca9 51 11 support support NN cord-331343-qzvwwca9 51 12 , , , cord-331343-qzvwwca9 51 13 amplify amplify VB cord-331343-qzvwwca9 51 14 them -PRON- PRP cord-331343-qzvwwca9 51 15 in in IN cord-331343-qzvwwca9 51 16 situ situ NN cord-331343-qzvwwca9 51 17 , , , cord-331343-qzvwwca9 51 18 perform perform VB cord-331343-qzvwwca9 51 19 sequence sequence NN cord-331343-qzvwwca9 51 20 - - HYPH cord-331343-qzvwwca9 51 21 dependent dependent JJ cord-331343-qzvwwca9 51 22 enzymatic enzymatic JJ cord-331343-qzvwwca9 51 23 reactions reaction NNS cord-331343-qzvwwca9 51 24 , , , cord-331343-qzvwwca9 51 25 and and CC cord-331343-qzvwwca9 51 26 then then RB cord-331343-qzvwwca9 51 27 detect detect VB cord-331343-qzvwwca9 51 28 the the DT cord-331343-qzvwwca9 51 29 outcomes outcome NNS cord-331343-qzvwwca9 51 30 to to TO cord-331343-qzvwwca9 51 31 determine determine VB cord-331343-qzvwwca9 51 32 sequence sequence NN cord-331343-qzvwwca9 51 33 content content NN cord-331343-qzvwwca9 51 34 ( ( -LRB- cord-331343-qzvwwca9 51 35 Fig Fig NNP cord-331343-qzvwwca9 51 36 . . . cord-331343-qzvwwca9 51 37 1 1 CD cord-331343-qzvwwca9 51 38 ) ) -RRB- cord-331343-qzvwwca9 51 39 . . . cord-331343-qzvwwca9 52 1 Given give VBN cord-331343-qzvwwca9 52 2 the the DT cord-331343-qzvwwca9 52 3 highly highly RB cord-331343-qzvwwca9 52 4 competitive competitive JJ cord-331343-qzvwwca9 52 5 nature nature NN cord-331343-qzvwwca9 52 6 of of IN cord-331343-qzvwwca9 52 7 this this DT cord-331343-qzvwwca9 52 8 industry industry NN cord-331343-qzvwwca9 52 9 , , , cord-331343-qzvwwca9 52 10 continuing continue VBG cord-331343-qzvwwca9 52 11 advances advance NNS cord-331343-qzvwwca9 52 12 in in IN cord-331343-qzvwwca9 52 13 sequencing sequence VBG cord-331343-qzvwwca9 52 14 technology technology NN cord-331343-qzvwwca9 52 15 and and CC cord-331343-qzvwwca9 52 16 falling fall VBG cord-331343-qzvwwca9 52 17 costs cost NNS cord-331343-qzvwwca9 52 18 are be VBP cord-331343-qzvwwca9 52 19 to to TO cord-331343-qzvwwca9 52 20 be be VB cord-331343-qzvwwca9 52 21 expected expect VBN cord-331343-qzvwwca9 52 22 . . . cord-331343-qzvwwca9 53 1 Accordingly accordingly RB cord-331343-qzvwwca9 53 2 , , , cord-331343-qzvwwca9 53 3 it -PRON- PRP cord-331343-qzvwwca9 53 4 is be VBZ cord-331343-qzvwwca9 53 5 just just RB cord-331343-qzvwwca9 53 6 a a DT cord-331343-qzvwwca9 53 7 matter matter NN cord-331343-qzvwwca9 53 8 of of IN cord-331343-qzvwwca9 53 9 time time NN cord-331343-qzvwwca9 53 10 before before IN cord-331343-qzvwwca9 53 11 metagenomics metagenomic NNS cord-331343-qzvwwca9 53 12 becomes become VBZ cord-331343-qzvwwca9 53 13 a a DT cord-331343-qzvwwca9 53 14 practical practical JJ cord-331343-qzvwwca9 53 15 research research NN cord-331343-qzvwwca9 53 16 technique technique NN cord-331343-qzvwwca9 53 17 for for IN cord-331343-qzvwwca9 53 18 determining determine VBG cord-331343-qzvwwca9 53 19 bacterial bacterial JJ cord-331343-qzvwwca9 53 20 and and CC cord-331343-qzvwwca9 53 21 viral viral JJ cord-331343-qzvwwca9 53 22 contents content NNS cord-331343-qzvwwca9 53 23 of of IN cord-331343-qzvwwca9 53 24 clinical clinical JJ cord-331343-qzvwwca9 53 25 samples sample NNS cord-331343-qzvwwca9 53 26 without without IN cord-331343-qzvwwca9 53 27 the the DT cord-331343-qzvwwca9 53 28 need need NN cord-331343-qzvwwca9 53 29 to to IN cord-331343-qzvwwca9 53 30 culture culture NN cord-331343-qzvwwca9 53 31 . . . cord-331343-qzvwwca9 54 1 15 15 CD cord-331343-qzvwwca9 54 2 Let let VB cord-331343-qzvwwca9 54 3 us -PRON- PRP cord-331343-qzvwwca9 54 4 go go VB cord-331343-qzvwwca9 54 5 back back RB cord-331343-qzvwwca9 54 6 to to IN cord-331343-qzvwwca9 54 7 the the DT cord-331343-qzvwwca9 54 8 plot plot NN cord-331343-qzvwwca9 54 9 : : : cord-331343-qzvwwca9 54 10 what what WP cord-331343-qzvwwca9 54 11 do do VBP cord-331343-qzvwwca9 54 12 we -PRON- PRP cord-331343-qzvwwca9 54 13 know know VB cord-331343-qzvwwca9 54 14 of of IN cord-331343-qzvwwca9 54 15 the the DT cord-331343-qzvwwca9 54 16 novel novel NN cord-331343-qzvwwca9 54 17 arenavirus arenavirus NNP cord-331343-qzvwwca9 54 18 found find VBN cord-331343-qzvwwca9 54 19 by by IN cord-331343-qzvwwca9 54 20 Palacios Palacios NNP cord-331343-qzvwwca9 54 21 and and CC cord-331343-qzvwwca9 54 22 colleagues colleague NNS cord-331343-qzvwwca9 54 23 ? ? . cord-331343-qzvwwca9 55 1 The the DT cord-331343-qzvwwca9 55 2 answer answer NN cord-331343-qzvwwca9 55 3 is be VBZ cord-331343-qzvwwca9 55 4 very very RB cord-331343-qzvwwca9 55 5 little little JJ cord-331343-qzvwwca9 55 6 , , , cord-331343-qzvwwca9 55 7 apart apart RB cord-331343-qzvwwca9 55 8 from from IN cord-331343-qzvwwca9 55 9 the the DT cord-331343-qzvwwca9 55 10 fact fact NN cord-331343-qzvwwca9 55 11 that that IN cord-331343-qzvwwca9 55 12 the the DT cord-331343-qzvwwca9 55 13 57-year 57-year JJ cord-331343-qzvwwca9 55 14 - - HYPH cord-331343-qzvwwca9 55 15 old old JJ cord-331343-qzvwwca9 55 16 male male JJ cord-331343-qzvwwca9 55 17 donor donor NN cord-331343-qzvwwca9 55 18 died die VBD cord-331343-qzvwwca9 55 19 from from IN cord-331343-qzvwwca9 55 20 a a DT cord-331343-qzvwwca9 55 21 cerebral cerebral JJ cord-331343-qzvwwca9 55 22 hemorrhage hemorrhage NN cord-331343-qzvwwca9 55 23 10 10 CD cord-331343-qzvwwca9 55 24 days day NNS cord-331343-qzvwwca9 55 25 after after IN cord-331343-qzvwwca9 55 26 returning return VBG cord-331343-qzvwwca9 55 27 to to IN cord-331343-qzvwwca9 55 28 Australia Australia NNP cord-331343-qzvwwca9 55 29 after after IN cord-331343-qzvwwca9 55 30 a a DT cord-331343-qzvwwca9 55 31 3-month 3-month CD cord-331343-qzvwwca9 55 32 visit visit NN cord-331343-qzvwwca9 55 33 to to IN cord-331343-qzvwwca9 55 34 rural rural JJ cord-331343-qzvwwca9 55 35 regions region NNS cord-331343-qzvwwca9 55 36 of of IN cord-331343-qzvwwca9 55 37 former former JJ cord-331343-qzvwwca9 55 38 Yugoslavia Yugoslavia NNP cord-331343-qzvwwca9 55 39 . . . cord-331343-qzvwwca9 56 1 1 1 CD cord-331343-qzvwwca9 56 2 Genetically Genetically NNP cord-331343-qzvwwca9 56 3 , , , cord-331343-qzvwwca9 56 4 the the DT cord-331343-qzvwwca9 56 5 agent agent NN cord-331343-qzvwwca9 56 6 shares share VBZ cord-331343-qzvwwca9 56 7 close close JJ cord-331343-qzvwwca9 56 8 homology homology NN cord-331343-qzvwwca9 56 9 with with IN cord-331343-qzvwwca9 56 10 other other JJ cord-331343-qzvwwca9 56 11 Old Old NNP cord-331343-qzvwwca9 56 12 World World NNP cord-331343-qzvwwca9 56 13 arenaviruses arenavirus NNS cord-331343-qzvwwca9 56 14 , , , cord-331343-qzvwwca9 56 15 such such JJ cord-331343-qzvwwca9 56 16 as as IN cord-331343-qzvwwca9 56 17 LCMV LCMV NNP cord-331343-qzvwwca9 56 18 and and CC cord-331343-qzvwwca9 56 19 the the DT cord-331343-qzvwwca9 56 20 Lassa Lassa NNP cord-331343-qzvwwca9 56 21 virus virus NN cord-331343-qzvwwca9 56 22 , , , cord-331343-qzvwwca9 56 23 that that WDT cord-331343-qzvwwca9 56 24 use use VBP cord-331343-qzvwwca9 56 25 rodents rodent NNS cord-331343-qzvwwca9 56 26 as as IN cord-331343-qzvwwca9 56 27 the the DT cord-331343-qzvwwca9 56 28 main main JJ cord-331343-qzvwwca9 56 29 reservoir reservoir NN cord-331343-qzvwwca9 56 30 of of IN cord-331343-qzvwwca9 56 31 infection infection NN cord-331343-qzvwwca9 56 32 . . . cord-331343-qzvwwca9 57 1 Lassa Lassa NNP cord-331343-qzvwwca9 57 2 virus virus NN cord-331343-qzvwwca9 57 3 is be VBZ cord-331343-qzvwwca9 57 4 usually usually RB cord-331343-qzvwwca9 57 5 passed pass VBN cord-331343-qzvwwca9 57 6 from from IN cord-331343-qzvwwca9 57 7 rodent rodent NN cord-331343-qzvwwca9 57 8 excreta excreta NN cord-331343-qzvwwca9 57 9 in in IN cord-331343-qzvwwca9 57 10 grain grain NN cord-331343-qzvwwca9 57 11 and and CC cord-331343-qzvwwca9 57 12 can can MD cord-331343-qzvwwca9 57 13 also also RB cord-331343-qzvwwca9 57 14 be be VB cord-331343-qzvwwca9 57 15 transmitted transmit VBN cord-331343-qzvwwca9 57 16 from from IN cord-331343-qzvwwca9 57 17 infected infected JJ cord-331343-qzvwwca9 57 18 patients patient NNS cord-331343-qzvwwca9 57 19 to to IN cord-331343-qzvwwca9 57 20 healthcare healthcare NN cord-331343-qzvwwca9 57 21 workers worker NNS cord-331343-qzvwwca9 57 22 . . . cord-331343-qzvwwca9 58 1 Although although IN cord-331343-qzvwwca9 58 2 no no DT cord-331343-qzvwwca9 58 3 wide wide RB cord-331343-qzvwwca9 58 4 - - HYPH cord-331343-qzvwwca9 58 5 ranging range VBG cord-331343-qzvwwca9 58 6 Lassa Lassa NNP cord-331343-qzvwwca9 58 7 virus virus NN cord-331343-qzvwwca9 58 8 epidemics epidemic NNS cord-331343-qzvwwca9 58 9 have have VBP cord-331343-qzvwwca9 58 10 occurred occur VBN cord-331343-qzvwwca9 58 11 , , , cord-331343-qzvwwca9 58 12 zoonoses zoonosis NNS cord-331343-qzvwwca9 58 13 from from IN cord-331343-qzvwwca9 58 14 mice mouse NNS cord-331343-qzvwwca9 58 15 cause cause VBP cord-331343-qzvwwca9 58 16 5000 5000 CD cord-331343-qzvwwca9 58 17 deaths death NNS cord-331343-qzvwwca9 58 18 from from IN cord-331343-qzvwwca9 58 19 hemorrhagic hemorrhagic JJ cord-331343-qzvwwca9 58 20 fever fever NN cord-331343-qzvwwca9 58 21 in in IN cord-331343-qzvwwca9 58 22 Western Western NNP cord-331343-qzvwwca9 58 23 Africa Africa NNP cord-331343-qzvwwca9 58 24 per per IN cord-331343-qzvwwca9 58 25 year year NN cord-331343-qzvwwca9 58 26 . . . cord-331343-qzvwwca9 59 1 20 20 CD cord-331343-qzvwwca9 60 1 Depending depend VBG cord-331343-qzvwwca9 60 2 on on IN cord-331343-qzvwwca9 60 3 the the DT cord-331343-qzvwwca9 60 4 location location NN cord-331343-qzvwwca9 60 5 , , , cord-331343-qzvwwca9 60 6 a a DT cord-331343-qzvwwca9 60 7 variable variable JJ cord-331343-qzvwwca9 60 8 proportion proportion NN cord-331343-qzvwwca9 60 9 ( ( -LRB- cord-331343-qzvwwca9 60 10 ϳ10 ϳ10 CD cord-331343-qzvwwca9 60 11 % % NN cord-331343-qzvwwca9 60 12 ) ) -RRB- cord-331343-qzvwwca9 60 13 of of IN cord-331343-qzvwwca9 60 14 the the DT cord-331343-qzvwwca9 60 15 population population NN cord-331343-qzvwwca9 60 16 has have VBZ cord-331343-qzvwwca9 60 17 serologic serologic JJ cord-331343-qzvwwca9 60 18 evidence evidence NN cord-331343-qzvwwca9 60 19 of of IN cord-331343-qzvwwca9 60 20 prior prior JJ cord-331343-qzvwwca9 60 21 Lassa Lassa NNP cord-331343-qzvwwca9 60 22 virus virus NN cord-331343-qzvwwca9 60 23 infection infection NN cord-331343-qzvwwca9 60 24 with with IN cord-331343-qzvwwca9 60 25 a a DT cord-331343-qzvwwca9 60 26 calculated calculated JJ cord-331343-qzvwwca9 60 27 ratio ratio NN cord-331343-qzvwwca9 60 28 of of IN cord-331343-qzvwwca9 60 29 infection infection NN cord-331343-qzvwwca9 60 30 to to IN cord-331343-qzvwwca9 60 31 fatality fatality NN cord-331343-qzvwwca9 60 32 of of IN cord-331343-qzvwwca9 60 33 approximately approximately RB cord-331343-qzvwwca9 60 34 1 1 CD cord-331343-qzvwwca9 60 35 % % NN cord-331343-qzvwwca9 60 36 to to TO cord-331343-qzvwwca9 60 37 2 2 CD cord-331343-qzvwwca9 60 38 % % NN cord-331343-qzvwwca9 60 39 . . . cord-331343-qzvwwca9 61 1 21 21 CD cord-331343-qzvwwca9 62 1 In in IN cord-331343-qzvwwca9 62 2 North North NNP cord-331343-qzvwwca9 62 3 America America NNP cord-331343-qzvwwca9 62 4 , , , cord-331343-qzvwwca9 62 5 the the DT cord-331343-qzvwwca9 62 6 seroprevalence seroprevalence NN cord-331343-qzvwwca9 62 7 of of IN cord-331343-qzvwwca9 62 8 LCMV LCMV NNP cord-331343-qzvwwca9 62 9 is be VBZ cord-331343-qzvwwca9 62 10 approximately approximately RB cord-331343-qzvwwca9 62 11 5 5 CD cord-331343-qzvwwca9 62 12 % % NN cord-331343-qzvwwca9 62 13 , , , cord-331343-qzvwwca9 62 14 and and CC cord-331343-qzvwwca9 62 15 the the DT cord-331343-qzvwwca9 62 16 estimated estimate VBN cord-331343-qzvwwca9 62 17 fatality fatality NN cord-331343-qzvwwca9 62 18 in in IN cord-331343-qzvwwca9 62 19 LCMV LCMV NNP cord-331343-qzvwwca9 62 20 - - HYPH cord-331343-qzvwwca9 62 21 infected infect VBN cord-331343-qzvwwca9 62 22 individuals individual NNS cord-331343-qzvwwca9 62 23 is be VBZ cord-331343-qzvwwca9 62 24 much much RB cord-331343-qzvwwca9 62 25 less less JJR cord-331343-qzvwwca9 62 26 than than IN cord-331343-qzvwwca9 62 27 1 1 CD cord-331343-qzvwwca9 62 28 % % NN cord-331343-qzvwwca9 62 29 , , , cord-331343-qzvwwca9 62 30 but but CC cord-331343-qzvwwca9 62 31 the the DT cord-331343-qzvwwca9 62 32 mortality mortality NN cord-331343-qzvwwca9 62 33 is be VBZ cord-331343-qzvwwca9 62 34 far far RB cord-331343-qzvwwca9 62 35 greater great JJR cord-331343-qzvwwca9 62 36 in in IN cord-331343-qzvwwca9 62 37 immunosuppressed immunosuppressed JJ cord-331343-qzvwwca9 62 38 and and CC cord-331343-qzvwwca9 62 39 otherwise otherwise RB cord-331343-qzvwwca9 62 40 vulnerable vulnerable JJ cord-331343-qzvwwca9 62 41 populations population NNS cord-331343-qzvwwca9 62 42 . . . cord-331343-qzvwwca9 63 1 3 3 CD cord-331343-qzvwwca9 63 2 , , , cord-331343-qzvwwca9 63 3 22 22 CD cord-331343-qzvwwca9 63 4 LCMV LCMV NNP cord-331343-qzvwwca9 63 5 infection infection NN cord-331343-qzvwwca9 63 6 is be VBZ cord-331343-qzvwwca9 63 7 associated associate VBN cord-331343-qzvwwca9 63 8 with with IN cord-331343-qzvwwca9 63 9 nonspecific nonspecific JJ cord-331343-qzvwwca9 63 10 symptoms symptom NNS cord-331343-qzvwwca9 63 11 such such JJ cord-331343-qzvwwca9 63 12 as as IN cord-331343-qzvwwca9 63 13 fever fever NN cord-331343-qzvwwca9 63 14 , , , cord-331343-qzvwwca9 63 15 myalgia myalgia NN cord-331343-qzvwwca9 63 16 , , , cord-331343-qzvwwca9 63 17 and and CC cord-331343-qzvwwca9 63 18 headache headache NN cord-331343-qzvwwca9 63 19 , , , cord-331343-qzvwwca9 63 20 and and CC cord-331343-qzvwwca9 63 21 viremia viremia NN cord-331343-qzvwwca9 63 22 is be VBZ cord-331343-qzvwwca9 63 23 limited limit VBN cord-331343-qzvwwca9 63 24 to to IN cord-331343-qzvwwca9 63 25 the the DT cord-331343-qzvwwca9 63 26 second second JJ cord-331343-qzvwwca9 63 27 week week NN cord-331343-qzvwwca9 63 28 of of IN cord-331343-qzvwwca9 63 29 infection infection NN cord-331343-qzvwwca9 63 30 in in IN cord-331343-qzvwwca9 63 31 immunocompetent immunocompetent JJ cord-331343-qzvwwca9 63 32 individuals individual NNS cord-331343-qzvwwca9 63 33 . . . cord-331343-qzvwwca9 64 1 Infrequently infrequently RB cord-331343-qzvwwca9 64 2 , , , cord-331343-qzvwwca9 64 3 a a DT cord-331343-qzvwwca9 64 4 second second JJ cord-331343-qzvwwca9 64 5 phase phase NN cord-331343-qzvwwca9 64 6 of of IN cord-331343-qzvwwca9 64 7 disease disease NN cord-331343-qzvwwca9 64 8 occurs occur VBZ cord-331343-qzvwwca9 64 9 after after IN cord-331343-qzvwwca9 64 10 convalescence convalescence NN cord-331343-qzvwwca9 64 11 with with IN cord-331343-qzvwwca9 64 12 meningitis meningitis NN cord-331343-qzvwwca9 64 13 and and CC cord-331343-qzvwwca9 64 14 infection infection NN cord-331343-qzvwwca9 64 15 disseminated disseminate VBN cord-331343-qzvwwca9 64 16 to to IN cord-331343-qzvwwca9 64 17 other other JJ cord-331343-qzvwwca9 64 18 organs organ NNS cord-331343-qzvwwca9 64 19 . . . cord-331343-qzvwwca9 65 1 3 3 CD cord-331343-qzvwwca9 65 2 , , , cord-331343-qzvwwca9 65 3 22 22 CD cord-331343-qzvwwca9 65 4 Therefore therefore RB cord-331343-qzvwwca9 65 5 , , , cord-331343-qzvwwca9 65 6 to to IN cord-331343-qzvwwca9 65 7 what what WDT cord-331343-qzvwwca9 65 8 extent extent NN cord-331343-qzvwwca9 65 9 should should MD cord-331343-qzvwwca9 65 10 we -PRON- PRP cord-331343-qzvwwca9 65 11 be be VB cord-331343-qzvwwca9 65 12 worried worry VBN cord-331343-qzvwwca9 65 13 by by IN cord-331343-qzvwwca9 65 14 rodent rodent NN cord-331343-qzvwwca9 65 15 infections infection NNS cord-331343-qzvwwca9 65 16 in in IN cord-331343-qzvwwca9 65 17 our -PRON- PRP$ cord-331343-qzvwwca9 65 18 transplant transplant NN cord-331343-qzvwwca9 65 19 patients patient NNS cord-331343-qzvwwca9 65 20 , , , cord-331343-qzvwwca9 65 21 and and CC cord-331343-qzvwwca9 65 22 should should MD cord-331343-qzvwwca9 65 23 we -PRON- PRP cord-331343-qzvwwca9 65 24 be be VB cord-331343-qzvwwca9 65 25 screening screen VBG cord-331343-qzvwwca9 65 26 donors donor NNS cord-331343-qzvwwca9 65 27 for for IN cord-331343-qzvwwca9 65 28 these these DT cord-331343-qzvwwca9 65 29 emerging emerge VBG cord-331343-qzvwwca9 65 30 pathogens pathogen NNS cord-331343-qzvwwca9 65 31 ? ? . cord-331343-qzvwwca9 66 1 We -PRON- PRP cord-331343-qzvwwca9 66 2 know know VBP cord-331343-qzvwwca9 66 3 that that IN cord-331343-qzvwwca9 66 4 about about RB cord-331343-qzvwwca9 66 5 60 60 CD cord-331343-qzvwwca9 66 6 % % NN cord-331343-qzvwwca9 66 7 of of IN cord-331343-qzvwwca9 66 8 emerging emerge VBG cord-331343-qzvwwca9 66 9 infectious infectious JJ cord-331343-qzvwwca9 66 10 diseases disease NNS cord-331343-qzvwwca9 66 11 in in IN cord-331343-qzvwwca9 66 12 humans human NNS cord-331343-qzvwwca9 66 13 occur occur VBP cord-331343-qzvwwca9 66 14 as as IN cord-331343-qzvwwca9 66 15 a a DT cord-331343-qzvwwca9 66 16 result result NN cord-331343-qzvwwca9 66 17 of of IN cord-331343-qzvwwca9 66 18 zoonoses zoonosis NNS cord-331343-qzvwwca9 66 19 . . . cord-331343-qzvwwca9 67 1 23 23 CD cord-331343-qzvwwca9 68 1 While while IN cord-331343-qzvwwca9 68 2 it -PRON- PRP cord-331343-qzvwwca9 68 3 is be VBZ cord-331343-qzvwwca9 68 4 rare rare JJ cord-331343-qzvwwca9 68 5 for for IN cord-331343-qzvwwca9 68 6 zoonotic zoonotic JJ cord-331343-qzvwwca9 68 7 viruses virus NNS cord-331343-qzvwwca9 68 8 to to TO cord-331343-qzvwwca9 68 9 adapt adapt VB cord-331343-qzvwwca9 68 10 to to TO cord-331343-qzvwwca9 68 11 become become VB cord-331343-qzvwwca9 68 12 epidemic epidemic NN cord-331343-qzvwwca9 68 13 in in IN cord-331343-qzvwwca9 68 14 humans human NNS cord-331343-qzvwwca9 68 15 , , , cord-331343-qzvwwca9 68 16 there there EX cord-331343-qzvwwca9 68 17 are be VBP cord-331343-qzvwwca9 68 18 notable notable JJ cord-331343-qzvwwca9 68 19 exceptions exception NNS cord-331343-qzvwwca9 68 20 , , , cord-331343-qzvwwca9 68 21 such such JJ cord-331343-qzvwwca9 68 22 as as IN cord-331343-qzvwwca9 68 23 the the DT cord-331343-qzvwwca9 68 24 severe severe JJ cord-331343-qzvwwca9 68 25 acute acute JJ cord-331343-qzvwwca9 68 26 respiratory respiratory JJ cord-331343-qzvwwca9 68 27 syndrome syndrome NN cord-331343-qzvwwca9 68 28 ( ( -LRB- cord-331343-qzvwwca9 68 29 SARS SARS NNP cord-331343-qzvwwca9 68 30 ) ) -RRB- cord-331343-qzvwwca9 68 31 virus virus NN cord-331343-qzvwwca9 68 32 epidemic epidemic NN cord-331343-qzvwwca9 68 33 that that WDT cord-331343-qzvwwca9 68 34 arose arise VBD cord-331343-qzvwwca9 68 35 as as IN cord-331343-qzvwwca9 68 36 a a DT cord-331343-qzvwwca9 68 37 result result NN cord-331343-qzvwwca9 68 38 of of IN cord-331343-qzvwwca9 68 39 a a DT cord-331343-qzvwwca9 68 40 zoonosis zoonosis NN cord-331343-qzvwwca9 68 41 from from IN cord-331343-qzvwwca9 68 42 bats bat NNS cord-331343-qzvwwca9 68 43 . . . cord-331343-qzvwwca9 69 1 24 24 CD cord-331343-qzvwwca9 70 1 On on IN cord-331343-qzvwwca9 70 2 occasion occasion NN cord-331343-qzvwwca9 70 3 , , , cord-331343-qzvwwca9 70 4 a a DT cord-331343-qzvwwca9 70 5 zoonosis zoonosis NN cord-331343-qzvwwca9 70 6 may may MD cord-331343-qzvwwca9 70 7 become become VB cord-331343-qzvwwca9 70 8 permanently permanently RB cord-331343-qzvwwca9 70 9 resident resident JJ cord-331343-qzvwwca9 70 10 in in IN cord-331343-qzvwwca9 70 11 the the DT cord-331343-qzvwwca9 70 12 human human JJ cord-331343-qzvwwca9 70 13 population population NN cord-331343-qzvwwca9 70 14 as as IN cord-331343-qzvwwca9 70 15 endemic endemic JJ cord-331343-qzvwwca9 70 16 infection infection NN cord-331343-qzvwwca9 70 17 , , , cord-331343-qzvwwca9 70 18 as as IN cord-331343-qzvwwca9 70 19 observed observe VBN cord-331343-qzvwwca9 70 20 with with IN cord-331343-qzvwwca9 70 21 human human JJ cord-331343-qzvwwca9 70 22 immunodeficiency immunodeficiency NN cord-331343-qzvwwca9 70 23 virus virus NN cord-331343-qzvwwca9 70 24 I i NN cord-331343-qzvwwca9 70 25 and and CC cord-331343-qzvwwca9 70 26 human human JJ cord-331343-qzvwwca9 70 27 immunodeficiency immunodeficiency NN cord-331343-qzvwwca9 70 28 virus virus NN cord-331343-qzvwwca9 70 29 II ii CD cord-331343-qzvwwca9 70 30 derived derive VBN cord-331343-qzvwwca9 70 31 from from IN cord-331343-qzvwwca9 70 32 chim chim NNP cord-331343-qzvwwca9 70 33 - - HYPH cord-331343-qzvwwca9 70 34 panzees panzees NNP cord-331343-qzvwwca9 70 35 and and CC cord-331343-qzvwwca9 70 36 sooty sooty JJ cord-331343-qzvwwca9 70 37 mangabeys mangabey NNS cord-331343-qzvwwca9 70 38 , , , cord-331343-qzvwwca9 70 39 respectively respectively RB cord-331343-qzvwwca9 70 40 . . . cord-331343-qzvwwca9 71 1 25 25 CD cord-331343-qzvwwca9 72 1 Thankfully thankfully RB cord-331343-qzvwwca9 72 2 , , , cord-331343-qzvwwca9 72 3 the the DT cord-331343-qzvwwca9 72 4 occurrence occurrence NN cord-331343-qzvwwca9 72 5 of of IN cord-331343-qzvwwca9 72 6 fatal fatal JJ cord-331343-qzvwwca9 72 7 rodent rodent NN cord-331343-qzvwwca9 72 8 - - HYPH cord-331343-qzvwwca9 72 9 borne bear VBN cord-331343-qzvwwca9 72 10 infections infection NNS cord-331343-qzvwwca9 72 11 in in IN cord-331343-qzvwwca9 72 12 our -PRON- PRP$ cord-331343-qzvwwca9 72 13 transplant transplant NN cord-331343-qzvwwca9 72 14 population population NN cord-331343-qzvwwca9 72 15 is be VBZ cord-331343-qzvwwca9 72 16 rare rare JJ cord-331343-qzvwwca9 72 17 . . . cord-331343-qzvwwca9 73 1 However however RB cord-331343-qzvwwca9 73 2 , , , cord-331343-qzvwwca9 73 3 is be VBZ cord-331343-qzvwwca9 73 4 it -PRON- PRP cord-331343-qzvwwca9 73 5 avoidable avoidable JJ cord-331343-qzvwwca9 73 6 ? ? . cord-331343-qzvwwca9 74 1 Currently currently RB cord-331343-qzvwwca9 74 2 , , , cord-331343-qzvwwca9 74 3 there there EX cord-331343-qzvwwca9 74 4 are be VBP cord-331343-qzvwwca9 74 5 no no DT cord-331343-qzvwwca9 74 6 Food Food NNP cord-331343-qzvwwca9 74 7 and and CC cord-331343-qzvwwca9 74 8 Drug Drug NNP cord-331343-qzvwwca9 74 9 Administration Administration NNP cord-331343-qzvwwca9 74 10 - - HYPH cord-331343-qzvwwca9 74 11 approved approve VBN cord-331343-qzvwwca9 74 12 diagnostic diagnostic JJ cord-331343-qzvwwca9 74 13 tests test NNS cord-331343-qzvwwca9 74 14 for for IN cord-331343-qzvwwca9 74 15 LCMV LCMV NNP cord-331343-qzvwwca9 74 16 or or CC cord-331343-qzvwwca9 74 17 the the DT cord-331343-qzvwwca9 74 18 newly newly RB cord-331343-qzvwwca9 74 19 discovered discover VBN cord-331343-qzvwwca9 74 20 arenavirus arenavirus NNP cord-331343-qzvwwca9 74 21 . . . cord-331343-qzvwwca9 75 1 Moreover moreover RB cord-331343-qzvwwca9 75 2 , , , cord-331343-qzvwwca9 75 3 the the DT cord-331343-qzvwwca9 75 4 testing testing NN cord-331343-qzvwwca9 75 5 of of IN cord-331343-qzvwwca9 75 6 donors donor NNS cord-331343-qzvwwca9 75 7 by by IN cord-331343-qzvwwca9 75 8 serology serology NN cord-331343-qzvwwca9 75 9 or or CC cord-331343-qzvwwca9 75 10 PCR PCR NNP cord-331343-qzvwwca9 75 11 may may MD cord-331343-qzvwwca9 75 12 not not RB cord-331343-qzvwwca9 75 13 be be VB cord-331343-qzvwwca9 75 14 cost cost NN cord-331343-qzvwwca9 75 15 - - HYPH cord-331343-qzvwwca9 75 16 effective effective JJ cord-331343-qzvwwca9 75 17 or or CC cord-331343-qzvwwca9 75 18 helpful helpful JJ cord-331343-qzvwwca9 75 19 in in IN cord-331343-qzvwwca9 75 20 detecting detect VBG cord-331343-qzvwwca9 75 21 an an DT cord-331343-qzvwwca9 75 22 acute acute JJ cord-331343-qzvwwca9 75 23 infection infection NN cord-331343-qzvwwca9 75 24 with with IN cord-331343-qzvwwca9 75 25 a a DT cord-331343-qzvwwca9 75 26 limited limited JJ cord-331343-qzvwwca9 75 27 window window NN cord-331343-qzvwwca9 75 28 of of IN cord-331343-qzvwwca9 75 29 viremia viremia NN cord-331343-qzvwwca9 75 30 . . . cord-331343-qzvwwca9 76 1 22 22 CD cord-331343-qzvwwca9 77 1 Thus thus RB cord-331343-qzvwwca9 77 2 , , , cord-331343-qzvwwca9 77 3 measures measure NNS cord-331343-qzvwwca9 77 4 to to TO cord-331343-qzvwwca9 77 5 limit limit VB cord-331343-qzvwwca9 77 6 the the DT cord-331343-qzvwwca9 77 7 spread spread NN cord-331343-qzvwwca9 77 8 of of IN cord-331343-qzvwwca9 77 9 viruses virus NNS cord-331343-qzvwwca9 77 10 may may MD cord-331343-qzvwwca9 77 11 provide provide VB cord-331343-qzvwwca9 77 12 a a DT cord-331343-qzvwwca9 77 13 degree degree NN cord-331343-qzvwwca9 77 14 of of IN cord-331343-qzvwwca9 77 15 protection protection NN cord-331343-qzvwwca9 77 16 . . . cord-331343-qzvwwca9 78 1 Pet pet NN cord-331343-qzvwwca9 78 2 hamsters hamster NNS cord-331343-qzvwwca9 78 3 have have VBP cord-331343-qzvwwca9 78 4 been be VBN cord-331343-qzvwwca9 78 5 implicated implicate VBN cord-331343-qzvwwca9 78 6 in in IN cord-331343-qzvwwca9 78 7 LCMV LCMV NNP cord-331343-qzvwwca9 78 8 outbreaks outbreak NNS cord-331343-qzvwwca9 78 9 , , , cord-331343-qzvwwca9 78 10 4 4 CD cord-331343-qzvwwca9 78 11 , , , cord-331343-qzvwwca9 78 12 22 22 CD cord-331343-qzvwwca9 78 13 and and CC cord-331343-qzvwwca9 78 14 infection infection NN cord-331343-qzvwwca9 78 15 in in IN cord-331343-qzvwwca9 78 16 expectant expectant JJ cord-331343-qzvwwca9 78 17 mothers mother NNS cord-331343-qzvwwca9 78 18 has have VBZ cord-331343-qzvwwca9 78 19 been be VBN cord-331343-qzvwwca9 78 20 linked link VBN cord-331343-qzvwwca9 78 21 to to IN cord-331343-qzvwwca9 78 22 intrauterine intrauterine JJ cord-331343-qzvwwca9 78 23 death death NN cord-331343-qzvwwca9 78 24 and and CC cord-331343-qzvwwca9 78 25 congenital congenital JJ cord-331343-qzvwwca9 78 26 LCMV LCMV NNP cord-331343-qzvwwca9 78 27 infection infection NN cord-331343-qzvwwca9 78 28 with with IN cord-331343-qzvwwca9 78 29 severe severe JJ cord-331343-qzvwwca9 78 30 neurological neurological JJ cord-331343-qzvwwca9 78 31 consequences consequence NNS cord-331343-qzvwwca9 78 32 in in IN cord-331343-qzvwwca9 78 33 the the DT cord-331343-qzvwwca9 78 34 newborn newborn NN cord-331343-qzvwwca9 78 35 . . . cord-331343-qzvwwca9 79 1 26 26 CD cord-331343-qzvwwca9 80 1 As as IN cord-331343-qzvwwca9 80 2 a a DT cord-331343-qzvwwca9 80 3 result result NN cord-331343-qzvwwca9 80 4 , , , cord-331343-qzvwwca9 80 5 our -PRON- PRP$ cord-331343-qzvwwca9 80 6 options option NNS cord-331343-qzvwwca9 80 7 for for IN cord-331343-qzvwwca9 80 8 controlling control VBG cord-331343-qzvwwca9 80 9 the the DT cord-331343-qzvwwca9 80 10 spread spread NN cord-331343-qzvwwca9 80 11 of of IN cord-331343-qzvwwca9 80 12 rodent rodent NN cord-331343-qzvwwca9 80 13 viruses virus NNS cord-331343-qzvwwca9 80 14 to to IN cord-331343-qzvwwca9 80 15 transplant transplant NN cord-331343-qzvwwca9 80 16 recipients recipient NNS cord-331343-qzvwwca9 80 17 may may MD cord-331343-qzvwwca9 80 18 be be VB cord-331343-qzvwwca9 80 19 limited limit VBN cord-331343-qzvwwca9 80 20 to to IN cord-331343-qzvwwca9 80 21 ensuring ensure VBG cord-331343-qzvwwca9 80 22 that that IN cord-331343-qzvwwca9 80 23 our -PRON- PRP$ cord-331343-qzvwwca9 80 24 pets pet NNS cord-331343-qzvwwca9 80 25 are be VBP cord-331343-qzvwwca9 80 26 free free JJ cord-331343-qzvwwca9 80 27 of of IN cord-331343-qzvwwca9 80 28 known know VBN cord-331343-qzvwwca9 80 29 human human JJ cord-331343-qzvwwca9 80 30 pathogens pathogen NNS cord-331343-qzvwwca9 80 31 . . . cord-331343-qzvwwca9 81 1 22 22 CD cord-331343-qzvwwca9 82 1 Indeed indeed RB cord-331343-qzvwwca9 82 2 , , , cord-331343-qzvwwca9 82 3 an an DT cord-331343-qzvwwca9 82 4 outbreak outbreak NN cord-331343-qzvwwca9 82 5 of of IN cord-331343-qzvwwca9 82 6 monkeypox monkeypox NN cord-331343-qzvwwca9 82 7 in in IN cord-331343-qzvwwca9 82 8 the the DT cord-331343-qzvwwca9 82 9 Midwestern Midwestern NNP cord-331343-qzvwwca9 82 10 United United NNP cord-331343-qzvwwca9 82 11 States States NNP cord-331343-qzvwwca9 82 12 from from IN cord-331343-qzvwwca9 82 13 pet pet JJ cord-331343-qzvwwca9 82 14 rodents rodent NNS cord-331343-qzvwwca9 82 15 27 27 CD cord-331343-qzvwwca9 82 16 underscores underscore VBZ cord-331343-qzvwwca9 82 17 the the DT cord-331343-qzvwwca9 82 18 need need NN cord-331343-qzvwwca9 82 19 for for IN cord-331343-qzvwwca9 82 20 implementation implementation NN cord-331343-qzvwwca9 82 21 of of IN cord-331343-qzvwwca9 82 22 tighter tight JJR cord-331343-qzvwwca9 82 23 regulations regulation NNS cord-331343-qzvwwca9 82 24 to to TO cord-331343-qzvwwca9 82 25 ensure ensure VB cord-331343-qzvwwca9 82 26 the the DT cord-331343-qzvwwca9 82 27 absence absence NN cord-331343-qzvwwca9 82 28 of of IN cord-331343-qzvwwca9 82 29 zoonotic zoonotic JJ cord-331343-qzvwwca9 82 30 viruses virus NNS cord-331343-qzvwwca9 82 31 in in IN cord-331343-qzvwwca9 82 32 pet pet JJ cord-331343-qzvwwca9 82 33 stores store NNS cord-331343-qzvwwca9 82 34 . . . cord-331343-qzvwwca9 83 1 22 22 CD cord-331343-qzvwwca9 84 1 Currently currently RB cord-331343-qzvwwca9 84 2 , , , cord-331343-qzvwwca9 84 3 a a DT cord-331343-qzvwwca9 84 4 detailed detailed JJ cord-331343-qzvwwca9 84 5 donor donor NN cord-331343-qzvwwca9 84 6 history history NN cord-331343-qzvwwca9 84 7 is be VBZ cord-331343-qzvwwca9 84 8 the the DT cord-331343-qzvwwca9 84 9 only only JJ cord-331343-qzvwwca9 84 10 screening screening NN cord-331343-qzvwwca9 84 11 methodology methodology NN cord-331343-qzvwwca9 84 12 that that WDT cord-331343-qzvwwca9 84 13 we -PRON- PRP cord-331343-qzvwwca9 84 14 have have VBP cord-331343-qzvwwca9 84 15 to to TO cord-331343-qzvwwca9 84 16 identify identify VB cord-331343-qzvwwca9 84 17 the the DT cord-331343-qzvwwca9 84 18 potential potential NN cord-331343-qzvwwca9 84 19 for for IN cord-331343-qzvwwca9 84 20 donor donor NN cord-331343-qzvwwca9 84 21 transmission transmission NN cord-331343-qzvwwca9 84 22 of of IN cord-331343-qzvwwca9 84 23 infectious infectious JJ cord-331343-qzvwwca9 84 24 agents agent NNS cord-331343-qzvwwca9 84 25 that that WDT cord-331343-qzvwwca9 84 26 can can MD cord-331343-qzvwwca9 84 27 not not RB cord-331343-qzvwwca9 84 28 be be VB cord-331343-qzvwwca9 84 29 readily readily RB cord-331343-qzvwwca9 84 30 detected detect VBN cord-331343-qzvwwca9 84 31 in in IN cord-331343-qzvwwca9 84 32 serum serum NN cord-331343-qzvwwca9 84 33 by by IN cord-331343-qzvwwca9 84 34 Food Food NNP cord-331343-qzvwwca9 84 35 and and CC cord-331343-qzvwwca9 84 36 Drug Drug NNP cord-331343-qzvwwca9 84 37 Administration Administration NNP cord-331343-qzvwwca9 84 38 - - HYPH cord-331343-qzvwwca9 84 39 approved approve VBN cord-331343-qzvwwca9 84 40 diagnostic diagnostic JJ cord-331343-qzvwwca9 84 41 methods method NNS cord-331343-qzvwwca9 84 42 ( ( -LRB- cord-331343-qzvwwca9 84 43 Table table NN cord-331343-qzvwwca9 84 44 1 1 CD cord-331343-qzvwwca9 84 45 ) ) -RRB- cord-331343-qzvwwca9 84 46 . . . cord-331343-qzvwwca9 85 1 To to TO cord-331343-qzvwwca9 85 2 prevent prevent VB cord-331343-qzvwwca9 85 3 LCMV LCMV NNP cord-331343-qzvwwca9 85 4 transmission transmission NN cord-331343-qzvwwca9 85 5 , , , cord-331343-qzvwwca9 85 6 for for IN cord-331343-qzvwwca9 85 7 example example NN cord-331343-qzvwwca9 85 8 , , , cord-331343-qzvwwca9 85 9 some some DT cord-331343-qzvwwca9 85 10 organ organ NN cord-331343-qzvwwca9 85 11 procurement procurement NN cord-331343-qzvwwca9 85 12 agencies agency NNS cord-331343-qzvwwca9 85 13 have have VBP cord-331343-qzvwwca9 85 14 taken take VBN cord-331343-qzvwwca9 85 15 an an DT cord-331343-qzvwwca9 85 16 approach approach NN cord-331343-qzvwwca9 85 17 similar similar JJ cord-331343-qzvwwca9 85 18 to to IN cord-331343-qzvwwca9 85 19 that that DT cord-331343-qzvwwca9 85 20 adopted adopt VBN cord-331343-qzvwwca9 85 21 for for IN cord-331343-qzvwwca9 85 22 avoidance avoidance NN cord-331343-qzvwwca9 85 23 of of IN cord-331343-qzvwwca9 85 24 West West NNP cord-331343-qzvwwca9 85 25 Nile Nile NNP cord-331343-qzvwwca9 85 26 virus virus NN cord-331343-qzvwwca9 85 27 infection infection NN cord-331343-qzvwwca9 85 28 , , , cord-331343-qzvwwca9 85 29 in in IN cord-331343-qzvwwca9 85 30 which which WDT cord-331343-qzvwwca9 85 31 donors donor NNS cord-331343-qzvwwca9 85 32 with with IN cord-331343-qzvwwca9 85 33 encephalitis encephalitis NN cord-331343-qzvwwca9 85 34 , , , cord-331343-qzvwwca9 85 35 meningitis meningitis NN cord-331343-qzvwwca9 85 36 , , , cord-331343-qzvwwca9 85 37 or or CC cord-331343-qzvwwca9 85 38 flaccid flaccid JJ cord-331343-qzvwwca9 85 39 paralysis paralysis NN cord-331343-qzvwwca9 85 40 of of IN cord-331343-qzvwwca9 85 41 undetermined undetermined JJ cord-331343-qzvwwca9 85 42 etiology etiology NN cord-331343-qzvwwca9 85 43 are be VBP cord-331343-qzvwwca9 85 44 deferred defer VBN cord-331343-qzvwwca9 85 45 . . . cord-331343-qzvwwca9 86 1 28 28 CD cord-331343-qzvwwca9 87 1 An an DT cord-331343-qzvwwca9 87 2 inquiry inquiry NN cord-331343-qzvwwca9 87 3 regarding regard VBG cord-331343-qzvwwca9 87 4 rodent rodent NN cord-331343-qzvwwca9 87 5 exposure exposure NN cord-331343-qzvwwca9 87 6 , , , cord-331343-qzvwwca9 87 7 such such JJ cord-331343-qzvwwca9 87 8 as as IN cord-331343-qzvwwca9 87 9 the the DT cord-331343-qzvwwca9 87 10 acquisition acquisition NN cord-331343-qzvwwca9 87 11 of of IN cord-331343-qzvwwca9 87 12 a a DT cord-331343-qzvwwca9 87 13 new new JJ cord-331343-qzvwwca9 87 14 pet pet NN cord-331343-qzvwwca9 87 15 within within IN cord-331343-qzvwwca9 87 16 the the DT cord-331343-qzvwwca9 87 17 preceding precede VBG cord-331343-qzvwwca9 87 18 6 6 CD cord-331343-qzvwwca9 87 19 weeks week NNS cord-331343-qzvwwca9 87 20 , , , cord-331343-qzvwwca9 87 21 may may MD cord-331343-qzvwwca9 87 22 identify identify VB cord-331343-qzvwwca9 87 23 potential potential JJ cord-331343-qzvwwca9 87 24 and and CC cord-331343-qzvwwca9 87 25 generally generally RB cord-331343-qzvwwca9 87 26 asymptomatic asymptomatic JJ cord-331343-qzvwwca9 87 27 LCMV LCMV NNP cord-331343-qzvwwca9 87 28 infection infection NN cord-331343-qzvwwca9 87 29 in in IN cord-331343-qzvwwca9 87 30 a a DT cord-331343-qzvwwca9 87 31 prospective prospective JJ cord-331343-qzvwwca9 87 32 donor donor NN cord-331343-qzvwwca9 87 33 . . . cord-331343-qzvwwca9 88 1 Unlike unlike IN cord-331343-qzvwwca9 88 2 West West NNP cord-331343-qzvwwca9 88 3 Nile Nile NNP cord-331343-qzvwwca9 88 4 virus virus NN cord-331343-qzvwwca9 88 5 , , , cord-331343-qzvwwca9 88 6 which which WDT cord-331343-qzvwwca9 88 7 has have VBZ cord-331343-qzvwwca9 88 8 a a DT cord-331343-qzvwwca9 88 9 specific specific JJ cord-331343-qzvwwca9 88 10 geographic geographic JJ cord-331343-qzvwwca9 88 11 distribution distribution NN cord-331343-qzvwwca9 88 12 and and CC cord-331343-qzvwwca9 88 13 a a DT cord-331343-qzvwwca9 88 14 seasonal seasonal JJ cord-331343-qzvwwca9 88 15 variance variance NN cord-331343-qzvwwca9 88 16 , , , cord-331343-qzvwwca9 88 17 LCMV LCMV NNP cord-331343-qzvwwca9 88 18 is be VBZ cord-331343-qzvwwca9 88 19 endemic endemic JJ cord-331343-qzvwwca9 88 20 in in IN cord-331343-qzvwwca9 88 21 rodents rodent NNS cord-331343-qzvwwca9 88 22 and and CC cord-331343-qzvwwca9 88 23 therefore therefore RB cord-331343-qzvwwca9 88 24 has have VBZ cord-331343-qzvwwca9 88 25 no no DT cord-331343-qzvwwca9 88 26 predictable predictable JJ cord-331343-qzvwwca9 88 27 pattern pattern NN cord-331343-qzvwwca9 88 28 . . . cord-331343-qzvwwca9 89 1 This this DT cord-331343-qzvwwca9 89 2 presents present VBZ cord-331343-qzvwwca9 89 3 a a DT cord-331343-qzvwwca9 89 4 real real JJ cord-331343-qzvwwca9 89 5 problem problem NN cord-331343-qzvwwca9 89 6 , , , cord-331343-qzvwwca9 89 7 as as IN cord-331343-qzvwwca9 89 8 mice mouse NNS cord-331343-qzvwwca9 89 9 are be VBP cord-331343-qzvwwca9 89 10 prevalent prevalent JJ cord-331343-qzvwwca9 89 11 in in IN cord-331343-qzvwwca9 89 12 most most JJS cord-331343-qzvwwca9 89 13 households household NNS cord-331343-qzvwwca9 89 14 and and CC cord-331343-qzvwwca9 89 15 are be VBP cord-331343-qzvwwca9 89 16 detected detect VBN cord-331343-qzvwwca9 89 17 in in IN cord-331343-qzvwwca9 89 18 up up IN cord-331343-qzvwwca9 89 19 to to TO cord-331343-qzvwwca9 89 20 95 95 CD cord-331343-qzvwwca9 89 21 % % NN cord-331343-qzvwwca9 89 22 of of IN cord-331343-qzvwwca9 89 23 residences residence NNS cord-331343-qzvwwca9 89 24 , , , cord-331343-qzvwwca9 89 25 especially especially RB cord-331343-qzvwwca9 89 26 in in IN cord-331343-qzvwwca9 89 27 kitchens kitchen NNS cord-331343-qzvwwca9 89 28 . . . cord-331343-qzvwwca9 90 1 29 29 CD cord-331343-qzvwwca9 91 1 We -PRON- PRP cord-331343-qzvwwca9 91 2 may may MD cord-331343-qzvwwca9 91 3 not not RB cord-331343-qzvwwca9 91 4 have have VB cord-331343-qzvwwca9 91 5 appreciated appreciate VBN cord-331343-qzvwwca9 91 6 the the DT cord-331343-qzvwwca9 91 7 full full JJ cord-331343-qzvwwca9 91 8 impact impact NN cord-331343-qzvwwca9 91 9 of of IN cord-331343-qzvwwca9 91 10 rodent rodent NN cord-331343-qzvwwca9 91 11 infections infection NNS cord-331343-qzvwwca9 91 12 on on IN cord-331343-qzvwwca9 91 13 human human JJ cord-331343-qzvwwca9 91 14 disease disease NN cord-331343-qzvwwca9 91 15 beyond beyond IN cord-331343-qzvwwca9 91 16 their -PRON- PRP$ cord-331343-qzvwwca9 91 17 obvious obvious JJ cord-331343-qzvwwca9 91 18 contribution contribution NN cord-331343-qzvwwca9 91 19 to to IN cord-331343-qzvwwca9 91 20 dramatic dramatic JJ cord-331343-qzvwwca9 91 21 disease disease NN cord-331343-qzvwwca9 91 22 outbreaks outbreak NNS cord-331343-qzvwwca9 91 23 such such JJ cord-331343-qzvwwca9 91 24 as as IN cord-331343-qzvwwca9 91 25 plague plague NN cord-331343-qzvwwca9 91 26 , , , cord-331343-qzvwwca9 91 27 typhus typhus NN cord-331343-qzvwwca9 91 28 , , , cord-331343-qzvwwca9 91 29 and and CC cord-331343-qzvwwca9 91 30 hanta hanta NNP cord-331343-qzvwwca9 91 31 virus virus NN cord-331343-qzvwwca9 91 32 . . . cord-331343-qzvwwca9 92 1 25 25 CD cord-331343-qzvwwca9 93 1 More more RBR cord-331343-qzvwwca9 93 2 recently recently RB cord-331343-qzvwwca9 93 3 , , , cord-331343-qzvwwca9 93 4 several several JJ cord-331343-qzvwwca9 93 5 mouse mouse NN cord-331343-qzvwwca9 93 6 viruses virus NNS cord-331343-qzvwwca9 93 7 have have VBP cord-331343-qzvwwca9 93 8 been be VBN cord-331343-qzvwwca9 93 9 implicated implicate VBN cord-331343-qzvwwca9 93 10 in in IN cord-331343-qzvwwca9 93 11 chronic chronic JJ cord-331343-qzvwwca9 93 12 human human JJ cord-331343-qzvwwca9 93 13 disorders disorder NNS cord-331343-qzvwwca9 93 14 , , , cord-331343-qzvwwca9 93 15 including include VBG cord-331343-qzvwwca9 93 16 the the DT cord-331343-qzvwwca9 93 17 endogenous endogenous JJ cord-331343-qzvwwca9 93 18 mouse mouse NN cord-331343-qzvwwca9 93 19 retroviruses retrovirus NNS cord-331343-qzvwwca9 93 20 , , , cord-331343-qzvwwca9 93 21 which which WDT cord-331343-qzvwwca9 93 22 can can MD cord-331343-qzvwwca9 93 23 be be VB cord-331343-qzvwwca9 93 24 expressed express VBN cord-331343-qzvwwca9 93 25 to to TO cord-331343-qzvwwca9 93 26 become become VB cord-331343-qzvwwca9 93 27 infectious infectious JJ cord-331343-qzvwwca9 93 28 agents agent NNS cord-331343-qzvwwca9 93 29 in in IN cord-331343-qzvwwca9 93 30 other other JJ cord-331343-qzvwwca9 93 31 species specie NNS cord-331343-qzvwwca9 93 32 . . . cord-331343-qzvwwca9 94 1 For for IN cord-331343-qzvwwca9 94 2 example example NN cord-331343-qzvwwca9 94 3 , , , cord-331343-qzvwwca9 94 4 the the DT cord-331343-qzvwwca9 94 5 mouse mouse NN cord-331343-qzvwwca9 94 6 mammary mammary JJ cord-331343-qzvwwca9 94 7 tumor tumor NN cord-331343-qzvwwca9 94 8 virus virus NN cord-331343-qzvwwca9 94 9 , , , cord-331343-qzvwwca9 94 10 a a DT cord-331343-qzvwwca9 94 11 murine murine JJ cord-331343-qzvwwca9 94 12 betaretrovirus betaretrovirus NNP cord-331343-qzvwwca9 94 13 , , , cord-331343-qzvwwca9 94 14 has have VBZ cord-331343-qzvwwca9 94 15 been be VBN cord-331343-qzvwwca9 94 16 linked link VBN cord-331343-qzvwwca9 94 17 to to IN cord-331343-qzvwwca9 94 18 human human JJ cord-331343-qzvwwca9 94 19 breast breast NN cord-331343-qzvwwca9 94 20 cancer cancer NN cord-331343-qzvwwca9 94 21 30 30 CD cord-331343-qzvwwca9 94 22 and and CC cord-331343-qzvwwca9 94 23 primary primary JJ cord-331343-qzvwwca9 94 24 biliary biliary JJ cord-331343-qzvwwca9 94 25 cirrhosis cirrhosis NN cord-331343-qzvwwca9 94 26 . . . cord-331343-qzvwwca9 95 1 31 31 CD cord-331343-qzvwwca9 95 2 , , , cord-331343-qzvwwca9 95 3 32 32 CD cord-331343-qzvwwca9 95 4 Mouse Mouse NNP cord-331343-qzvwwca9 95 5 gammaretroviruses gammaretroviruse NNS cord-331343-qzvwwca9 95 6 have have VBP cord-331343-qzvwwca9 95 7 also also RB cord-331343-qzvwwca9 95 8 been be VBN cord-331343-qzvwwca9 95 9 identified identify VBN cord-331343-qzvwwca9 95 10 in in IN cord-331343-qzvwwca9 95 11 human human JJ cord-331343-qzvwwca9 95 12 samples sample NNS cord-331343-qzvwwca9 95 13 , , , cord-331343-qzvwwca9 95 14 such such JJ cord-331343-qzvwwca9 95 15 as as IN cord-331343-qzvwwca9 95 16 the the DT cord-331343-qzvwwca9 95 17 xenotrophic xenotrophic NNP cord-331343-qzvwwca9 95 18 murine murine NNP cord-331343-qzvwwca9 95 19 leukemia leukemia NN cord-331343-qzvwwca9 95 20 virus virus NN cord-331343-qzvwwca9 95 21 ( ( -LRB- cord-331343-qzvwwca9 95 22 MuLV)-related mulv)-relate VBN cord-331343-qzvwwca9 95 23 virus virus NN cord-331343-qzvwwca9 95 24 found find VBN cord-331343-qzvwwca9 95 25 in in IN cord-331343-qzvwwca9 95 26 human human JJ cord-331343-qzvwwca9 95 27 prostate prostate NN cord-331343-qzvwwca9 95 28 cancer cancer NN cord-331343-qzvwwca9 95 29 33 33 CD cord-331343-qzvwwca9 95 30 and and CC cord-331343-qzvwwca9 95 31 MuLV MuLV NNP cord-331343-qzvwwca9 95 32 sequences sequence NNS cord-331343-qzvwwca9 95 33 found find VBN cord-331343-qzvwwca9 95 34 in in IN cord-331343-qzvwwca9 95 35 normal normal JJ cord-331343-qzvwwca9 95 36 gut gut NN cord-331343-qzvwwca9 95 37 flora flora NNS cord-331343-qzvwwca9 95 38 detected detect VBN cord-331343-qzvwwca9 95 39 by by IN cord-331343-qzvwwca9 95 40 metagenomic metagenomic NNP cord-331343-qzvwwca9 95 41 analysis analysis NNP cord-331343-qzvwwca9 95 42 . . . cord-331343-qzvwwca9 96 1 11 11 CD cord-331343-qzvwwca9 97 1 Although although IN cord-331343-qzvwwca9 97 2 the the DT cord-331343-qzvwwca9 97 3 diverse diverse JJ cord-331343-qzvwwca9 97 4 roles role NNS cord-331343-qzvwwca9 97 5 of of IN cord-331343-qzvwwca9 97 6 these these DT cord-331343-qzvwwca9 97 7 agents agent NNS cord-331343-qzvwwca9 97 8 in in IN cord-331343-qzvwwca9 97 9 human human JJ cord-331343-qzvwwca9 97 10 disease disease NN cord-331343-qzvwwca9 97 11 have have VBP cord-331343-qzvwwca9 97 12 yet yet RB cord-331343-qzvwwca9 97 13 to to TO cord-331343-qzvwwca9 97 14 be be VB cord-331343-qzvwwca9 97 15 determined determine VBN cord-331343-qzvwwca9 97 16 and and CC cord-331343-qzvwwca9 97 17 remain remain VBP cord-331343-qzvwwca9 97 18 a a DT cord-331343-qzvwwca9 97 19 source source NN cord-331343-qzvwwca9 97 20 of of IN cord-331343-qzvwwca9 97 21 controversy controversy NN cord-331343-qzvwwca9 97 22 , , , cord-331343-qzvwwca9 97 23 further further JJ cord-331343-qzvwwca9 97 24 metagenomic metagenomic NNP cord-331343-qzvwwca9 97 25 studies study NNS cord-331343-qzvwwca9 97 26 are be VBP cord-331343-qzvwwca9 97 27 likely likely JJ cord-331343-qzvwwca9 97 28 to to TO cord-331343-qzvwwca9 97 29 tell tell VB cord-331343-qzvwwca9 97 30 us -PRON- PRP cord-331343-qzvwwca9 97 31 the the DT cord-331343-qzvwwca9 97 32 diversity diversity NN cord-331343-qzvwwca9 97 33 of of IN cord-331343-qzvwwca9 97 34 rodent rodent NN cord-331343-qzvwwca9 97 35 microbial microbial JJ cord-331343-qzvwwca9 97 36 agents agent NNS cord-331343-qzvwwca9 97 37 that that WDT cord-331343-qzvwwca9 97 38 can can MD cord-331343-qzvwwca9 97 39 be be VB cord-331343-qzvwwca9 97 40 found find VBN cord-331343-qzvwwca9 97 41 in in IN cord-331343-qzvwwca9 97 42 humans human NNS cord-331343-qzvwwca9 97 43 . . . cord-331343-qzvwwca9 98 1 Until until IN cord-331343-qzvwwca9 98 2 then then RB cord-331343-qzvwwca9 98 3 , , , cord-331343-qzvwwca9 98 4 additional additional JJ cord-331343-qzvwwca9 98 5 vigilance vigilance NN cord-331343-qzvwwca9 98 6 and and CC cord-331343-qzvwwca9 98 7 a a DT cord-331343-qzvwwca9 98 8 detailed detailed JJ cord-331343-qzvwwca9 98 9 donor donor NN cord-331343-qzvwwca9 98 10 history history NN cord-331343-qzvwwca9 98 11 for for IN cord-331343-qzvwwca9 98 12 rodent rodent NN cord-331343-qzvwwca9 98 13 exposure exposure NN cord-331343-qzvwwca9 98 14 will will MD cord-331343-qzvwwca9 98 15 be be VB cord-331343-qzvwwca9 98 16 required require VBN cord-331343-qzvwwca9 98 17 to to TO cord-331343-qzvwwca9 98 18 prevent prevent VB cord-331343-qzvwwca9 98 19 the the DT cord-331343-qzvwwca9 98 20 introduction introduction NN cord-331343-qzvwwca9 98 21 of of IN cord-331343-qzvwwca9 98 22 zoonotic zoonotic JJ cord-331343-qzvwwca9 98 23 infections infection NNS cord-331343-qzvwwca9 98 24 into into IN cord-331343-qzvwwca9 98 25 our -PRON- PRP$ cord-331343-qzvwwca9 98 26 transplant transplant NN cord-331343-qzvwwca9 98 27 recipients recipient NNS cord-331343-qzvwwca9 98 28 . . . cord-331343-qzvwwca9 98 29 _SP cord-331343-qzvwwca9 99 1 A a DT cord-331343-qzvwwca9 99 2 new new JJ cord-331343-qzvwwca9 99 3 arenavirus arenavirus NN cord-331343-qzvwwca9 99 4 in in IN cord-331343-qzvwwca9 99 5 a a DT cord-331343-qzvwwca9 99 6 cluster cluster NN cord-331343-qzvwwca9 99 7 of of IN cord-331343-qzvwwca9 99 8 fatal fatal JJ cord-331343-qzvwwca9 99 9 transplant transplant NN cord-331343-qzvwwca9 99 10 - - HYPH cord-331343-qzvwwca9 99 11 associated associate VBN cord-331343-qzvwwca9 99 12 diseases disease NNS cord-331343-qzvwwca9 100 1 Rodent rodent NN cord-331343-qzvwwca9 100 2 virus virus NN cord-331343-qzvwwca9 100 3 infected infect VBN cord-331343-qzvwwca9 100 4 - - HYPH cord-331343-qzvwwca9 100 5 kidney kidney NN cord-331343-qzvwwca9 100 6 kills kill VBZ cord-331343-qzvwwca9 100 7 transplant transplant NN cord-331343-qzvwwca9 100 8 recipient recipient NN cord-331343-qzvwwca9 100 9 Transmission transmission NN cord-331343-qzvwwca9 100 10 of of IN cord-331343-qzvwwca9 100 11 lymphocytic lymphocytic JJ cord-331343-qzvwwca9 100 12 choriomeningitis choriomeningitis NNP cord-331343-qzvwwca9 100 13 virus virus NN cord-331343-qzvwwca9 100 14 by by IN cord-331343-qzvwwca9 100 15 organ organ NN cord-331343-qzvwwca9 100 16 transplantation transplantation NN cord-331343-qzvwwca9 100 17 Lymphocyticchoriomeningitis lymphocyticchoriomeningitis NN cord-331343-qzvwwca9 100 18 - - HYPH cord-331343-qzvwwca9 100 19 virus virus NN cord-331343-qzvwwca9 100 20 infection infection NN cord-331343-qzvwwca9 100 21 traced trace VBD cord-331343-qzvwwca9 100 22 to to IN cord-331343-qzvwwca9 100 23 a a DT cord-331343-qzvwwca9 100 24 pet pet JJ cord-331343-qzvwwca9 100 25 hamster hamster NN cord-331343-qzvwwca9 100 26 Panmicrobial Panmicrobial NNP cord-331343-qzvwwca9 100 27 oligonucleotide oligonucleotide JJ cord-331343-qzvwwca9 100 28 array array NN cord-331343-qzvwwca9 100 29 for for IN cord-331343-qzvwwca9 100 30 diagnosis diagnosis NN cord-331343-qzvwwca9 100 31 of of IN cord-331343-qzvwwca9 100 32 infectious infectious JJ cord-331343-qzvwwca9 100 33 diseases disease NNS cord-331343-qzvwwca9 100 34 Metagenomics metagenomic NNS cord-331343-qzvwwca9 100 35 : : : cord-331343-qzvwwca9 100 36 genomic genomic JJ cord-331343-qzvwwca9 100 37 analysis analysis NN cord-331343-qzvwwca9 100 38 of of IN cord-331343-qzvwwca9 100 39 microbial microbial JJ cord-331343-qzvwwca9 100 40 communities community NNS cord-331343-qzvwwca9 100 41 Metagenomic Metagenomic NNP cord-331343-qzvwwca9 100 42 analysis analysis NN cord-331343-qzvwwca9 100 43 of of IN cord-331343-qzvwwca9 100 44 coastal coastal JJ cord-331343-qzvwwca9 100 45 RNA RNA NNP cord-331343-qzvwwca9 100 46 virus virus NN cord-331343-qzvwwca9 100 47 communities community NNS cord-331343-qzvwwca9 101 1 A a DT cord-331343-qzvwwca9 101 2 metagenomic metagenomic NN cord-331343-qzvwwca9 101 3 survey survey NN cord-331343-qzvwwca9 101 4 of of IN cord-331343-qzvwwca9 101 5 microbes microbe NNS cord-331343-qzvwwca9 101 6 in in IN cord-331343-qzvwwca9 101 7 honey honey NN cord-331343-qzvwwca9 101 8 bee bee NNP cord-331343-qzvwwca9 101 9 colony colony NNP cord-331343-qzvwwca9 101 10 collapse collapse NN cord-331343-qzvwwca9 101 11 disorder disorder NN cord-331343-qzvwwca9 102 1 An an DT cord-331343-qzvwwca9 102 2 obesity obesity NN cord-331343-qzvwwca9 102 3 - - HYPH cord-331343-qzvwwca9 102 4 associated associate VBN cord-331343-qzvwwca9 102 5 gut gut NN cord-331343-qzvwwca9 102 6 microbiome microbiome NN cord-331343-qzvwwca9 102 7 with with IN cord-331343-qzvwwca9 102 8 increased increase VBN cord-331343-qzvwwca9 102 9 capacity capacity NN cord-331343-qzvwwca9 102 10 for for IN cord-331343-qzvwwca9 102 11 energy energy NN cord-331343-qzvwwca9 102 12 harvest harvest NN cord-331343-qzvwwca9 102 13 Metagenomic Metagenomic NNP cord-331343-qzvwwca9 102 14 analyses analysis NNS cord-331343-qzvwwca9 102 15 of of IN cord-331343-qzvwwca9 102 16 an an DT cord-331343-qzvwwca9 102 17 uncultured uncultured JJ cord-331343-qzvwwca9 102 18 viral viral JJ cord-331343-qzvwwca9 102 19 community community NN cord-331343-qzvwwca9 102 20 from from IN cord-331343-qzvwwca9 102 21 human human JJ cord-331343-qzvwwca9 102 22 feces fece NNS cord-331343-qzvwwca9 102 23 RNA RNA NNP cord-331343-qzvwwca9 102 24 viral viral JJ cord-331343-qzvwwca9 102 25 community community NN cord-331343-qzvwwca9 102 26 in in IN cord-331343-qzvwwca9 102 27 human human JJ cord-331343-qzvwwca9 102 28 feces fece NNS cord-331343-qzvwwca9 102 29 : : : cord-331343-qzvwwca9 102 30 prevalence prevalence NN cord-331343-qzvwwca9 102 31 of of IN cord-331343-qzvwwca9 102 32 plant plant NN cord-331343-qzvwwca9 102 33 pathogenic pathogenic JJ cord-331343-qzvwwca9 102 34 viruses virus NNS cord-331343-qzvwwca9 103 1 Metagenomic Metagenomic NNP cord-331343-qzvwwca9 103 2 analysis analysis NN cord-331343-qzvwwca9 103 3 of of IN cord-331343-qzvwwca9 103 4 human human JJ cord-331343-qzvwwca9 103 5 diarrhea diarrhea NN cord-331343-qzvwwca9 103 6 : : : cord-331343-qzvwwca9 103 7 viral viral JJ cord-331343-qzvwwca9 103 8 detection detection NN cord-331343-qzvwwca9 103 9 and and CC cord-331343-qzvwwca9 103 10 discovery discovery NN cord-331343-qzvwwca9 104 1 The the DT cord-331343-qzvwwca9 104 2 human human JJ cord-331343-qzvwwca9 104 3 microbiome microbiome NN cord-331343-qzvwwca9 104 4 project project NN cord-331343-qzvwwca9 104 5 Clonal Clonal NNP cord-331343-qzvwwca9 104 6 integration integration NN cord-331343-qzvwwca9 104 7 of of IN cord-331343-qzvwwca9 104 8 a a DT cord-331343-qzvwwca9 104 9 polyomavirus polyomavirus NNP cord-331343-qzvwwca9 104 10 in in IN cord-331343-qzvwwca9 104 11 human human JJ cord-331343-qzvwwca9 104 12 Merkel Merkel NNP cord-331343-qzvwwca9 104 13 cell cell NN cord-331343-qzvwwca9 104 14 carcinoma carcinoma NN cord-331343-qzvwwca9 104 15 Viral viral JJ cord-331343-qzvwwca9 104 16 metagenomics metagenomic NNS cord-331343-qzvwwca9 104 17 Identification identification NN cord-331343-qzvwwca9 104 18 of of IN cord-331343-qzvwwca9 104 19 the the DT cord-331343-qzvwwca9 104 20 major major JJ cord-331343-qzvwwca9 104 21 non non JJ cord-331343-qzvwwca9 104 22 - - JJ cord-331343-qzvwwca9 104 23 A a JJ cord-331343-qzvwwca9 104 24 non non JJ cord-331343-qzvwwca9 104 25 - - JJ cord-331343-qzvwwca9 104 26 B b JJ cord-331343-qzvwwca9 104 27 hepatitis hepatitis NN cord-331343-qzvwwca9 104 28 agent agent NN cord-331343-qzvwwca9 104 29 ( ( -LRB- cord-331343-qzvwwca9 104 30 hepatitis hepatitis NNP cord-331343-qzvwwca9 104 31 C C NNP cord-331343-qzvwwca9 104 32 virus virus NN cord-331343-qzvwwca9 104 33 ) ) -RRB- cord-331343-qzvwwca9 104 34 using use VBG cord-331343-qzvwwca9 104 35 a a DT cord-331343-qzvwwca9 104 36 recombinant recombinant JJ cord-331343-qzvwwca9 104 37 cDNA cdna NN cord-331343-qzvwwca9 104 38 approach approach NN cord-331343-qzvwwca9 104 39 Breakthrough Breakthrough NNP cord-331343-qzvwwca9 104 40 of of IN cord-331343-qzvwwca9 104 41 the the DT cord-331343-qzvwwca9 104 42 year year NN cord-331343-qzvwwca9 104 43 . . . cord-331343-qzvwwca9 105 1 Human human JJ cord-331343-qzvwwca9 105 2 genetic genetic JJ cord-331343-qzvwwca9 105 3 variation variation NN cord-331343-qzvwwca9 106 1 A a DT cord-331343-qzvwwca9 106 2 plan plan NN cord-331343-qzvwwca9 106 3 to to TO cord-331343-qzvwwca9 106 4 capture capture VB cord-331343-qzvwwca9 106 5 human human JJ cord-331343-qzvwwca9 106 6 diversity diversity NN cord-331343-qzvwwca9 106 7 in in IN cord-331343-qzvwwca9 106 8 1000 1000 CD cord-331343-qzvwwca9 106 9 genomes genome NNS cord-331343-qzvwwca9 106 10 A a DT cord-331343-qzvwwca9 106 11 draft draft NN cord-331343-qzvwwca9 106 12 sequence sequence NN cord-331343-qzvwwca9 106 13 of of IN cord-331343-qzvwwca9 106 14 the the DT cord-331343-qzvwwca9 106 15 rice rice NN cord-331343-qzvwwca9 106 16 genome genome NN cord-331343-qzvwwca9 107 1 ( ( -LRB- cord-331343-qzvwwca9 107 2 Oryza oryza NN cord-331343-qzvwwca9 107 3 sativa sativa NN cord-331343-qzvwwca9 107 4 L. L. NNP cord-331343-qzvwwca9 107 5 ssp ssp NNP cord-331343-qzvwwca9 107 6 . . . cord-331343-qzvwwca9 108 1 indica indica NNP cord-331343-qzvwwca9 108 2 ) ) -RRB- cord-331343-qzvwwca9 109 1 Lassa Lassa NNP cord-331343-qzvwwca9 109 2 fever fever NN cord-331343-qzvwwca9 109 3 in in IN cord-331343-qzvwwca9 109 4 West west JJ cord-331343-qzvwwca9 109 5 African african JJ cord-331343-qzvwwca9 109 6 subregion subregion NN cord-331343-qzvwwca9 109 7 : : : cord-331343-qzvwwca9 109 8 an an DT cord-331343-qzvwwca9 109 9 overview overview NN cord-331343-qzvwwca9 109 10 A a DT cord-331343-qzvwwca9 109 11 prospective prospective JJ cord-331343-qzvwwca9 109 12 study study NN cord-331343-qzvwwca9 109 13 of of IN cord-331343-qzvwwca9 109 14 the the DT cord-331343-qzvwwca9 109 15 epidemiology epidemiology NN cord-331343-qzvwwca9 109 16 and and CC cord-331343-qzvwwca9 109 17 ecology ecology NN cord-331343-qzvwwca9 109 18 of of IN cord-331343-qzvwwca9 109 19 Lassa Lassa NNP cord-331343-qzvwwca9 109 20 fever fever NN cord-331343-qzvwwca9 109 21 Lymphocytic lymphocytic JJ cord-331343-qzvwwca9 109 22 choriomeningitis choriomeningitis NN cord-331343-qzvwwca9 109 23 virus virus NN cord-331343-qzvwwca9 109 24 - - : cord-331343-qzvwwca9 109 25 an an DT cord-331343-qzvwwca9 109 26 old old JJ cord-331343-qzvwwca9 109 27 enemy enemy NN cord-331343-qzvwwca9 109 28 up up IN cord-331343-qzvwwca9 109 29 to to IN cord-331343-qzvwwca9 109 30 new new JJ cord-331343-qzvwwca9 109 31 tricks trick NNS cord-331343-qzvwwca9 110 1 Global global JJ cord-331343-qzvwwca9 110 2 trends trend NNS cord-331343-qzvwwca9 110 3 in in IN cord-331343-qzvwwca9 110 4 emerging emerge VBG cord-331343-qzvwwca9 110 5 infectious infectious JJ cord-331343-qzvwwca9 110 6 diseases disease NNS cord-331343-qzvwwca9 111 1 The the DT cord-331343-qzvwwca9 111 2 genome genome NN cord-331343-qzvwwca9 111 3 sequence sequence NN cord-331343-qzvwwca9 111 4 of of IN cord-331343-qzvwwca9 111 5 the the DT cord-331343-qzvwwca9 111 6 SARS SARS NNP cord-331343-qzvwwca9 111 7 - - HYPH cord-331343-qzvwwca9 111 8 associated associate VBN cord-331343-qzvwwca9 111 9 coronavirus coronavirus NN cord-331343-qzvwwca9 111 10 Animal Animal NNP cord-331343-qzvwwca9 111 11 origins origin NNS cord-331343-qzvwwca9 111 12 of of IN cord-331343-qzvwwca9 111 13 human human JJ cord-331343-qzvwwca9 111 14 infectious infectious JJ cord-331343-qzvwwca9 111 15 disease disease NN cord-331343-qzvwwca9 111 16 LCMV LCMV NNP cord-331343-qzvwwca9 111 17 transmission transmission NN cord-331343-qzvwwca9 111 18 by by IN cord-331343-qzvwwca9 111 19 organ organ NN cord-331343-qzvwwca9 111 20 transplantation transplantation NN cord-331343-qzvwwca9 112 1 The the DT cord-331343-qzvwwca9 112 2 detection detection NN cord-331343-qzvwwca9 112 3 of of IN cord-331343-qzvwwca9 112 4 monkeypox monkeypox NN cord-331343-qzvwwca9 112 5 in in IN cord-331343-qzvwwca9 112 6 humans human NNS cord-331343-qzvwwca9 112 7 in in IN cord-331343-qzvwwca9 112 8 the the DT cord-331343-qzvwwca9 112 9 Western western JJ cord-331343-qzvwwca9 112 10 hemisphere hemisphere NN cord-331343-qzvwwca9 112 11 Transmission Transmission NNP cord-331343-qzvwwca9 112 12 of of IN cord-331343-qzvwwca9 112 13 West West NNP cord-331343-qzvwwca9 112 14 Nile Nile NNP cord-331343-qzvwwca9 112 15 virus virus NN cord-331343-qzvwwca9 112 16 from from IN cord-331343-qzvwwca9 112 17 an an DT cord-331343-qzvwwca9 112 18 organ organ NN cord-331343-qzvwwca9 112 19 donor donor NN cord-331343-qzvwwca9 112 20 to to IN cord-331343-qzvwwca9 112 21 four four CD cord-331343-qzvwwca9 112 22 transplant transplant NN cord-331343-qzvwwca9 112 23 recipients recipient NNS cord-331343-qzvwwca9 112 24 Mouse Mouse NNP cord-331343-qzvwwca9 112 25 allergen allergen NN cord-331343-qzvwwca9 112 26 . . . cord-331343-qzvwwca9 112 27 I. i. NN cord-331343-qzvwwca9 113 1 The the DT cord-331343-qzvwwca9 113 2 prevalence prevalence NN cord-331343-qzvwwca9 113 3 of of IN cord-331343-qzvwwca9 113 4 mouse mouse NN cord-331343-qzvwwca9 113 5 allergen allergen NN cord-331343-qzvwwca9 113 6 in in IN cord-331343-qzvwwca9 113 7 inner inner JJ cord-331343-qzvwwca9 113 8 - - HYPH cord-331343-qzvwwca9 113 9 city city NN cord-331343-qzvwwca9 113 10 homes home NNS cord-331343-qzvwwca9 113 11 . . . cord-331343-qzvwwca9 114 1 The the DT cord-331343-qzvwwca9 114 2 National National NNP cord-331343-qzvwwca9 114 3 Cooperative Cooperative NNP cord-331343-qzvwwca9 114 4 Inner Inner NNP cord-331343-qzvwwca9 114 5 - - HYPH cord-331343-qzvwwca9 114 6 City City NNP cord-331343-qzvwwca9 114 7 Asthma Asthma NNP cord-331343-qzvwwca9 114 8 Study Study NNP cord-331343-qzvwwca9 114 9 Possibilities Possibilities NNPS cord-331343-qzvwwca9 114 10 of of IN cord-331343-qzvwwca9 114 11 a a DT cord-331343-qzvwwca9 114 12 viral viral JJ cord-331343-qzvwwca9 114 13 etiology etiology NN cord-331343-qzvwwca9 114 14 for for IN cord-331343-qzvwwca9 114 15 human human JJ cord-331343-qzvwwca9 114 16 breast breast NN cord-331343-qzvwwca9 114 17 cancer cancer NN cord-331343-qzvwwca9 114 18 Cloning clone VBG cord-331343-qzvwwca9 114 19 the the DT cord-331343-qzvwwca9 114 20 human human JJ cord-331343-qzvwwca9 114 21 betaretrovirus betaretrovirus NNP cord-331343-qzvwwca9 114 22 proviral proviral NNP cord-331343-qzvwwca9 114 23 genome genome NNP cord-331343-qzvwwca9 114 24 from from IN cord-331343-qzvwwca9 114 25 patients patient NNS cord-331343-qzvwwca9 114 26 with with IN cord-331343-qzvwwca9 114 27 primary primary JJ cord-331343-qzvwwca9 114 28 biliary biliary JJ cord-331343-qzvwwca9 114 29 cirrhosis cirrhosis NN cord-331343-qzvwwca9 115 1 Does do VBZ cord-331343-qzvwwca9 115 2 a a DT cord-331343-qzvwwca9 115 3 betaretrovirus betaretrovirus NNP cord-331343-qzvwwca9 115 4 infection infection NN cord-331343-qzvwwca9 115 5 trigger trigger NN cord-331343-qzvwwca9 115 6 primary primary JJ cord-331343-qzvwwca9 115 7 biliary biliary JJ cord-331343-qzvwwca9 115 8 cirrhosis cirrhosis NN cord-331343-qzvwwca9 115 9 ? ? . cord-331343-qzvwwca9 116 1 Identification identification NN cord-331343-qzvwwca9 116 2 of of IN cord-331343-qzvwwca9 116 3 a a DT cord-331343-qzvwwca9 116 4 novel novel JJ cord-331343-qzvwwca9 116 5 gammaretrovirus gammaretrovirus NN cord-331343-qzvwwca9 116 6 in in IN cord-331343-qzvwwca9 116 7 prostate prostate NN cord-331343-qzvwwca9 116 8 tumors tumor NNS cord-331343-qzvwwca9 116 9 of of IN cord-331343-qzvwwca9 116 10 patients patient NNS cord-331343-qzvwwca9 116 11 homozygous homozygous JJ cord-331343-qzvwwca9 116 12 for for IN cord-331343-qzvwwca9 116 13 R462Q R462Q NNP cord-331343-qzvwwca9 116 14 RNASEL RNASEL NNP cord-331343-qzvwwca9 116 15 variant variant NN cord-331343-qzvwwca9 116 16 Screening screening NN cord-331343-qzvwwca9 116 17 of of IN cord-331343-qzvwwca9 116 18 donor donor NN cord-331343-qzvwwca9 116 19 and and CC cord-331343-qzvwwca9 116 20 recipient recipient NN cord-331343-qzvwwca9 116 21 prior prior RB cord-331343-qzvwwca9 116 22 to to IN cord-331343-qzvwwca9 116 23 solid solid JJ cord-331343-qzvwwca9 116 24 organ organ NN cord-331343-qzvwwca9 116 25 transplantation transplantation NN cord-331343-qzvwwca9 117 1 There there EX cord-331343-qzvwwca9 117 2 are be VBP cord-331343-qzvwwca9 117 3 currently currently RB cord-331343-qzvwwca9 117 4 no no DT cord-331343-qzvwwca9 117 5 approved approve VBN cord-331343-qzvwwca9 117 6 antifibrotic antifibrotic JJ cord-331343-qzvwwca9 117 7 therapies therapy NNS cord-331343-qzvwwca9 117 8 for for IN cord-331343-qzvwwca9 117 9 liver liver NN cord-331343-qzvwwca9 117 10 cirrhosis cirrhosis NN cord-331343-qzvwwca9 117 11 . . . cord-331343-qzvwwca9 118 1 We -PRON- PRP cord-331343-qzvwwca9 118 2 used use VBD cord-331343-qzvwwca9 118 3 vitamin vitamin NN cord-331343-qzvwwca9 118 4 A a NN cord-331343-qzvwwca9 118 5 - - HYPH cord-331343-qzvwwca9 118 6 coupled coupled JJ cord-331343-qzvwwca9 118 7 liposomes liposome NNS cord-331343-qzvwwca9 118 8 to to TO cord-331343-qzvwwca9 118 9 deliver deliver VB cord-331343-qzvwwca9 118 10 small small JJ cord-331343-qzvwwca9 118 11 interfering interfere VBG cord-331343-qzvwwca9 118 12 RNA RNA NNP cord-331343-qzvwwca9 118 13 ( ( -LRB- cord-331343-qzvwwca9 118 14 siRNA siRNA NNP cord-331343-qzvwwca9 118 15 ) ) -RRB- cord-331343-qzvwwca9 118 16 against against IN cord-331343-qzvwwca9 118 17 gp46 gp46 NNP cord-331343-qzvwwca9 118 18 , , , cord-331343-qzvwwca9 118 19 the the DT cord-331343-qzvwwca9 118 20 rat rat NN cord-331343-qzvwwca9 118 21 homolog homolog NN cord-331343-qzvwwca9 118 22 of of IN cord-331343-qzvwwca9 118 23 human human JJ cord-331343-qzvwwca9 118 24 heat heat NN cord-331343-qzvwwca9 118 25 shock shock NN cord-331343-qzvwwca9 118 26 protein protein NN cord-331343-qzvwwca9 118 27 47 47 CD cord-331343-qzvwwca9 118 28 , , , cord-331343-qzvwwca9 118 29 to to IN cord-331343-qzvwwca9 118 30 hepatic hepatic JJ cord-331343-qzvwwca9 118 31 stellate stellate JJ cord-331343-qzvwwca9 118 32 cells cell NNS cord-331343-qzvwwca9 118 33 . . . cord-331343-qzvwwca9 119 1 Our -PRON- PRP$ cord-331343-qzvwwca9 119 2 approach approach NN cord-331343-qzvwwca9 119 3 exploits exploit VBZ cord-331343-qzvwwca9 119 4 the the DT cord-331343-qzvwwca9 119 5 key key JJ cord-331343-qzvwwca9 119 6 roles role NNS cord-331343-qzvwwca9 119 7 of of IN cord-331343-qzvwwca9 119 8 these these DT cord-331343-qzvwwca9 119 9 cells cell NNS cord-331343-qzvwwca9 119 10 in in IN cord-331343-qzvwwca9 119 11 both both DT cord-331343-qzvwwca9 119 12 fibrogenesis fibrogenesis NN cord-331343-qzvwwca9 119 13 as as RB cord-331343-qzvwwca9 119 14 well well RB cord-331343-qzvwwca9 119 15 as as IN cord-331343-qzvwwca9 119 16 uptake uptake NN cord-331343-qzvwwca9 119 17 and and CC cord-331343-qzvwwca9 119 18 storage storage NN cord-331343-qzvwwca9 119 19 of of IN cord-331343-qzvwwca9 119 20 vitamin vitamin NN cord-331343-qzvwwca9 119 21 A. a. NN cord-331343-qzvwwca9 119 22 Five five CD cord-331343-qzvwwca9 119 23 treatments treatment NNS cord-331343-qzvwwca9 119 24 with with IN cord-331343-qzvwwca9 119 25 the the DT cord-331343-qzvwwca9 119 26 siRNAbearing sirnabeare VBG cord-331343-qzvwwca9 119 27 vitamin vitamin NN cord-331343-qzvwwca9 119 28 A a NN cord-331343-qzvwwca9 119 29 - - HYPH cord-331343-qzvwwca9 119 30 coupled coupled JJ cord-331343-qzvwwca9 119 31 liposomes liposome NNS cord-331343-qzvwwca9 119 32 almost almost RB cord-331343-qzvwwca9 119 33 completely completely RB cord-331343-qzvwwca9 119 34 resolved resolve VBD cord-331343-qzvwwca9 119 35 liver liver NN cord-331343-qzvwwca9 119 36 fibrosis fibrosis NN cord-331343-qzvwwca9 119 37 and and CC cord-331343-qzvwwca9 119 38 prolonged prolong VBN cord-331343-qzvwwca9 119 39 survival survival NN cord-331343-qzvwwca9 119 40 in in IN cord-331343-qzvwwca9 119 41 rats rat NNS cord-331343-qzvwwca9 119 42 with with IN cord-331343-qzvwwca9 119 43 otherwise otherwise RB cord-331343-qzvwwca9 119 44 lethal lethal JJ cord-331343-qzvwwca9 119 45 dimethylnitrosamine dimethylnitrosamine NN cord-331343-qzvwwca9 119 46 - - HYPH cord-331343-qzvwwca9 119 47 induced induce VBN cord-331343-qzvwwca9 119 48 liver liver NN cord-331343-qzvwwca9 119 49 cirrhosis cirrhosis NN cord-331343-qzvwwca9 119 50 in in IN cord-331343-qzvwwca9 119 51 a a DT cord-331343-qzvwwca9 119 52 dose dose NN cord-331343-qzvwwca9 119 53 - - HYPH cord-331343-qzvwwca9 119 54 and and CC cord-331343-qzvwwca9 119 55 duration duration NN cord-331343-qzvwwca9 119 56 - - HYPH cord-331343-qzvwwca9 119 57 dependent dependent JJ cord-331343-qzvwwca9 119 58 manner manner NN cord-331343-qzvwwca9 119 59 . . . cord-331343-qzvwwca9 120 1 Rescue rescue NN cord-331343-qzvwwca9 120 2 was be VBD cord-331343-qzvwwca9 120 3 not not RB cord-331343-qzvwwca9 120 4 related relate VBN cord-331343-qzvwwca9 120 5 to to IN cord-331343-qzvwwca9 120 6 off off IN cord-331343-qzvwwca9 120 7 - - HYPH cord-331343-qzvwwca9 120 8 target target NN cord-331343-qzvwwca9 120 9 effects effect NNS cord-331343-qzvwwca9 120 10 or or CC cord-331343-qzvwwca9 120 11 associated associate VBN cord-331343-qzvwwca9 120 12 with with IN cord-331343-qzvwwca9 120 13 recruitment recruitment NN cord-331343-qzvwwca9 120 14 of of IN cord-331343-qzvwwca9 120 15 innate innate JJ cord-331343-qzvwwca9 120 16 immunity immunity NN cord-331343-qzvwwca9 120 17 . . . cord-331343-qzvwwca9 121 1 Receptorspecific Receptorspecific NNP cord-331343-qzvwwca9 121 2 siRNA siRNA NNP cord-331343-qzvwwca9 121 3 delivery delivery NN cord-331343-qzvwwca9 121 4 was be VBD cord-331343-qzvwwca9 121 5 similarly similarly RB cord-331343-qzvwwca9 121 6 effective effective JJ cord-331343-qzvwwca9 121 7 in in IN cord-331343-qzvwwca9 121 8 suppressing suppress VBG cord-331343-qzvwwca9 121 9 collagen collagen NN cord-331343-qzvwwca9 121 10 secretion secretion NN cord-331343-qzvwwca9 121 11 and and CC cord-331343-qzvwwca9 121 12 treating treat VBG cord-331343-qzvwwca9 121 13 fibrosis fibrosis NN cord-331343-qzvwwca9 121 14 induced induce VBN cord-331343-qzvwwca9 121 15 by by IN cord-331343-qzvwwca9 121 16 CCl CCl NNS cord-331343-qzvwwca9 121 17 4 4 CD cord-331343-qzvwwca9 121 18 or or CC cord-331343-qzvwwca9 121 19 bile bile NN cord-331343-qzvwwca9 121 20 duct duct NN cord-331343-qzvwwca9 121 21 ligation ligation NN cord-331343-qzvwwca9 121 22 . . . cord-331343-qzvwwca9 122 1 The the DT cord-331343-qzvwwca9 122 2 efficacy efficacy NN cord-331343-qzvwwca9 122 3 of of IN cord-331343-qzvwwca9 122 4 the the DT cord-331343-qzvwwca9 122 5 approach approach NN cord-331343-qzvwwca9 122 6 using use VBG cord-331343-qzvwwca9 122 7 both both CC cord-331343-qzvwwca9 122 8 acute acute JJ cord-331343-qzvwwca9 122 9 and and CC cord-331343-qzvwwca9 122 10 chronic chronic JJ cord-331343-qzvwwca9 122 11 models model NNS cord-331343-qzvwwca9 122 12 of of IN cord-331343-qzvwwca9 122 13 liver liver NN cord-331343-qzvwwca9 122 14 fibrosis fibrosis NN cord-331343-qzvwwca9 122 15 suggests suggest VBZ cord-331343-qzvwwca9 122 16 its -PRON- PRP$ cord-331343-qzvwwca9 122 17 therapeutic therapeutic JJ cord-331343-qzvwwca9 122 18 potential potential NN cord-331343-qzvwwca9 122 19 for for IN cord-331343-qzvwwca9 122 20 reversing reverse VBG cord-331343-qzvwwca9 122 21 human human JJ cord-331343-qzvwwca9 122 22 liver liver NN cord-331343-qzvwwca9 122 23 cirrhosis cirrhosis NN cord-331343-qzvwwca9 122 24 . . . cord-331343-qzvwwca9 123 1 Progressive progressive JJ cord-331343-qzvwwca9 123 2 liver liver NN cord-331343-qzvwwca9 123 3 fibrosis fibrosis NN cord-331343-qzvwwca9 123 4 , , , cord-331343-qzvwwca9 123 5 or or CC cord-331343-qzvwwca9 123 6 scarring scarring NN cord-331343-qzvwwca9 123 7 of of IN cord-331343-qzvwwca9 123 8 the the DT cord-331343-qzvwwca9 123 9 liver liver NN cord-331343-qzvwwca9 123 10 , , , cord-331343-qzvwwca9 123 11 as as IN cord-331343-qzvwwca9 123 12 the the DT cord-331343-qzvwwca9 123 13 common common JJ cord-331343-qzvwwca9 123 14 consequence consequence NN cord-331343-qzvwwca9 123 15 of of IN cord-331343-qzvwwca9 123 16 all all DT cord-331343-qzvwwca9 123 17 chronic chronic JJ cord-331343-qzvwwca9 123 18 liver liver NN cord-331343-qzvwwca9 123 19 diseases disease NNS cord-331343-qzvwwca9 123 20 is be VBZ cord-331343-qzvwwca9 123 21 a a DT cord-331343-qzvwwca9 123 22 major major JJ cord-331343-qzvwwca9 123 23 medical medical JJ cord-331343-qzvwwca9 123 24 and and CC cord-331343-qzvwwca9 123 25 economic economic JJ cord-331343-qzvwwca9 123 26 challenge challenge NN cord-331343-qzvwwca9 123 27 , , , cord-331343-qzvwwca9 123 28 because because IN cord-331343-qzvwwca9 123 29 there there EX cord-331343-qzvwwca9 123 30 are be VBP cord-331343-qzvwwca9 123 31 no no DT cord-331343-qzvwwca9 123 32 effective effective JJ cord-331343-qzvwwca9 123 33 treatment treatment NN cord-331343-qzvwwca9 123 34 options option NNS cord-331343-qzvwwca9 123 35 except except IN cord-331343-qzvwwca9 123 36 liver liver NN cord-331343-qzvwwca9 123 37 transplantation transplantation NN cord-331343-qzvwwca9 123 38 . . . cord-331343-qzvwwca9 124 1 The the DT cord-331343-qzvwwca9 124 2 current current JJ cord-331343-qzvwwca9 124 3 paradigm paradigm NN cord-331343-qzvwwca9 124 4 attributes attribute VBZ cord-331343-qzvwwca9 124 5 this this DT cord-331343-qzvwwca9 124 6 fibrogenic fibrogenic JJ cord-331343-qzvwwca9 124 7 response response NN cord-331343-qzvwwca9 124 8 to to IN cord-331343-qzvwwca9 124 9 hepatic hepatic JJ cord-331343-qzvwwca9 124 10 stellate stellate JJ cord-331343-qzvwwca9 124 11 cells cell NNS cord-331343-qzvwwca9 124 12 ( ( -LRB- cord-331343-qzvwwca9 124 13 HSCs HSCs NNP cord-331343-qzvwwca9 124 14 ) ) -RRB- cord-331343-qzvwwca9 124 15 , , , cord-331343-qzvwwca9 124 16 which which WDT cord-331343-qzvwwca9 124 17 reside reside VBP cord-331343-qzvwwca9 124 18 in in IN cord-331343-qzvwwca9 124 19 the the DT cord-331343-qzvwwca9 124 20 subendothelial subendothelial JJ cord-331343-qzvwwca9 124 21 space space NN cord-331343-qzvwwca9 124 22 of of IN cord-331343-qzvwwca9 124 23 Disse Disse NNP cord-331343-qzvwwca9 124 24 and and CC cord-331343-qzvwwca9 124 25 are be VBP cord-331343-qzvwwca9 124 26 the the DT cord-331343-qzvwwca9 124 27 major major JJ cord-331343-qzvwwca9 124 28 storage storage NN cord-331343-qzvwwca9 124 29 site site NN cord-331343-qzvwwca9 124 30 for for IN cord-331343-qzvwwca9 124 31 vitamin vitamin NN cord-331343-qzvwwca9 124 32 A a NN cord-331343-qzvwwca9 124 33 in in IN cord-331343-qzvwwca9 124 34 healthy healthy JJ cord-331343-qzvwwca9 124 35 humans human NNS cord-331343-qzvwwca9 124 36 . . . cord-331343-qzvwwca9 125 1 In in IN cord-331343-qzvwwca9 125 2 response response NN cord-331343-qzvwwca9 125 3 to to IN cord-331343-qzvwwca9 125 4 injury injury NN cord-331343-qzvwwca9 125 5 , , , cord-331343-qzvwwca9 125 6 HSCs hsc NNS cord-331343-qzvwwca9 125 7 undergo undergo VBP cord-331343-qzvwwca9 125 8 an an DT cord-331343-qzvwwca9 125 9 activation activation NN cord-331343-qzvwwca9 125 10 process process NN cord-331343-qzvwwca9 125 11 in in IN cord-331343-qzvwwca9 125 12 which which WDT cord-331343-qzvwwca9 125 13 they -PRON- PRP cord-331343-qzvwwca9 125 14 lose lose VBP cord-331343-qzvwwca9 125 15 vitamin vitamin NN cord-331343-qzvwwca9 125 16 A a NN cord-331343-qzvwwca9 125 17 , , , cord-331343-qzvwwca9 125 18 become become VBN cord-331343-qzvwwca9 125 19 highly highly RB cord-331343-qzvwwca9 125 20 proliferative proliferative JJ cord-331343-qzvwwca9 125 21 , , , cord-331343-qzvwwca9 125 22 and and CC cord-331343-qzvwwca9 125 23 synthesize synthesize VB cord-331343-qzvwwca9 125 24 abnormal abnormal JJ cord-331343-qzvwwca9 125 25 extracellular extracellular JJ cord-331343-qzvwwca9 125 26 matrix matrix NN cord-331343-qzvwwca9 125 27 , , , cord-331343-qzvwwca9 125 28 including include VBG cord-331343-qzvwwca9 125 29 excessive excessive JJ cord-331343-qzvwwca9 125 30 collagen collagen NN cord-331343-qzvwwca9 125 31 , , , cord-331343-qzvwwca9 125 32 various various JJ cord-331343-qzvwwca9 125 33 proteoglycans proteoglycan NNS cord-331343-qzvwwca9 125 34 , , , cord-331343-qzvwwca9 125 35 and and CC cord-331343-qzvwwca9 125 36 structural structural JJ cord-331343-qzvwwca9 125 37 glycoproteins glycoprotein NNS cord-331343-qzvwwca9 125 38 . . . cord-331343-qzvwwca9 126 1 1 1 LS cord-331343-qzvwwca9 127 1 This this DT cord-331343-qzvwwca9 127 2 activation activation NN cord-331343-qzvwwca9 127 3 process process NN cord-331343-qzvwwca9 127 4 and and CC cord-331343-qzvwwca9 127 5 the the DT cord-331343-qzvwwca9 127 6 deposition deposition NN cord-331343-qzvwwca9 127 7 of of IN cord-331343-qzvwwca9 127 8 extracellular extracellular JJ cord-331343-qzvwwca9 127 9 matrix matrix NN cord-331343-qzvwwca9 127 10 in in IN cord-331343-qzvwwca9 127 11 the the DT cord-331343-qzvwwca9 127 12 space space NN cord-331343-qzvwwca9 127 13 of of IN cord-331343-qzvwwca9 127 14 Disse Disse NNP cord-331343-qzvwwca9 127 15 are be VBP cord-331343-qzvwwca9 127 16 commonly commonly RB cord-331343-qzvwwca9 127 17 considered consider VBN cord-331343-qzvwwca9 127 18 to to TO cord-331343-qzvwwca9 127 19 represent represent VB cord-331343-qzvwwca9 127 20 the the DT cord-331343-qzvwwca9 127 21 key key JJ cord-331343-qzvwwca9 127 22 pathogenetic pathogenetic JJ cord-331343-qzvwwca9 127 23 events event NNS cord-331343-qzvwwca9 127 24 in in IN cord-331343-qzvwwca9 127 25 liver liver NN cord-331343-qzvwwca9 127 26 fibrosis fibrosis NN cord-331343-qzvwwca9 127 27 . . . cord-331343-qzvwwca9 128 1 2 2 LS cord-331343-qzvwwca9 129 1 Previous previous JJ cord-331343-qzvwwca9 129 2 studies study NNS cord-331343-qzvwwca9 129 3 showed show VBD cord-331343-qzvwwca9 129 4 that that IN cord-331343-qzvwwca9 129 5 the the DT cord-331343-qzvwwca9 129 6 collagen collagen NN cord-331343-qzvwwca9 129 7 - - HYPH cord-331343-qzvwwca9 129 8 specific specific JJ cord-331343-qzvwwca9 129 9 chaperone chaperone NN cord-331343-qzvwwca9 129 10 heat heat NN cord-331343-qzvwwca9 129 11 shock shock NN cord-331343-qzvwwca9 129 12 protein protein NN cord-331343-qzvwwca9 129 13 47 47 CD cord-331343-qzvwwca9 129 14 ( ( -LRB- cord-331343-qzvwwca9 129 15 HSP47)-also hsp47)-also RB cord-331343-qzvwwca9 129 16 termed term VBD cord-331343-qzvwwca9 129 17 J6 j6 NN cord-331343-qzvwwca9 129 18 , , , cord-331343-qzvwwca9 129 19 gp46 gp46 NNP cord-331343-qzvwwca9 129 20 , , , cord-331343-qzvwwca9 129 21 collagen collagen NN cord-331343-qzvwwca9 129 22 - - HYPH cord-331343-qzvwwca9 129 23 binding bind VBG cord-331343-qzvwwca9 129 24 48 48 CD cord-331343-qzvwwca9 129 25 kDa kDa NNS cord-331343-qzvwwca9 129 26 protein protein NN cord-331343-qzvwwca9 129 27 ( ( -LRB- cord-331343-qzvwwca9 129 28 CB48 CB48 NNP cord-331343-qzvwwca9 129 29 ) ) -RRB- cord-331343-qzvwwca9 129 30 , , , cord-331343-qzvwwca9 129 31 collagen collagen NN cord-331343-qzvwwca9 129 32 binding bind VBG cord-331343-qzvwwca9 129 33 protein protein NN cord-331343-qzvwwca9 129 34 2 2 CD cord-331343-qzvwwca9 129 35 ( ( -LRB- cord-331343-qzvwwca9 129 36 CBP2 CBP2 NNP cord-331343-qzvwwca9 129 37 ) ) -RRB- cord-331343-qzvwwca9 129 38 , , , cord-331343-qzvwwca9 129 39 or or CC cord-331343-qzvwwca9 129 40 colligin colligin NNP cord-331343-qzvwwca9 129 41 - - HYPH cord-331343-qzvwwca9 129 42 plays play VBZ cord-331343-qzvwwca9 129 43 an an DT cord-331343-qzvwwca9 129 44 essential essential JJ cord-331343-qzvwwca9 129 45 role role NN cord-331343-qzvwwca9 129 46 in in IN cord-331343-qzvwwca9 129 47 regulating regulate VBG cord-331343-qzvwwca9 129 48 collagen collagen NN cord-331343-qzvwwca9 129 49 synthesis synthesis NN cord-331343-qzvwwca9 129 50 . . . cord-331343-qzvwwca9 130 1 It -PRON- PRP cord-331343-qzvwwca9 130 2 is be VBZ cord-331343-qzvwwca9 130 3 constitutively constitutively RB cord-331343-qzvwwca9 130 4 expressed express VBN cord-331343-qzvwwca9 130 5 with with IN cord-331343-qzvwwca9 130 6 collagens collagen NNS cord-331343-qzvwwca9 130 7 and and CC cord-331343-qzvwwca9 130 8 binds bind VBZ cord-331343-qzvwwca9 130 9 to to IN cord-331343-qzvwwca9 130 10 both both DT cord-331343-qzvwwca9 130 11 helical helical JJ cord-331343-qzvwwca9 130 12 and and CC cord-331343-qzvwwca9 130 13 nonhelical nonhelical JJ cord-331343-qzvwwca9 130 14 forms form NNS cord-331343-qzvwwca9 130 15 of of IN cord-331343-qzvwwca9 130 16 collagens collagen NNS cord-331343-qzvwwca9 130 17 . . . cord-331343-qzvwwca9 131 1 3 3 LS cord-331343-qzvwwca9 132 1 The the DT cord-331343-qzvwwca9 132 2 link link NN cord-331343-qzvwwca9 132 3 between between IN cord-331343-qzvwwca9 132 4 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 132 5 and and CC cord-331343-qzvwwca9 132 6 collagen collagen NN cord-331343-qzvwwca9 132 7 production production NN cord-331343-qzvwwca9 132 8 was be VBD cord-331343-qzvwwca9 132 9 demonstrated demonstrate VBN cord-331343-qzvwwca9 132 10 in in IN cord-331343-qzvwwca9 132 11 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 132 12 knockout knockout NN cord-331343-qzvwwca9 132 13 mice mouse NNS cord-331343-qzvwwca9 132 14 that that WDT cord-331343-qzvwwca9 132 15 are be VBP cord-331343-qzvwwca9 132 16 severely severely RB cord-331343-qzvwwca9 132 17 deficient deficient JJ cord-331343-qzvwwca9 132 18 in in IN cord-331343-qzvwwca9 132 19 the the DT cord-331343-qzvwwca9 132 20 mature mature JJ cord-331343-qzvwwca9 132 21 , , , cord-331343-qzvwwca9 132 22 propeptide propeptide RB cord-331343-qzvwwca9 132 23 - - HYPH cord-331343-qzvwwca9 132 24 processed process VBN cord-331343-qzvwwca9 132 25 form form NN cord-331343-qzvwwca9 132 26 of of IN cord-331343-qzvwwca9 132 27 ␣ ␣ NNP cord-331343-qzvwwca9 132 28 ( ( -LRB- cord-331343-qzvwwca9 132 29 I i NN cord-331343-qzvwwca9 132 30 ) ) -RRB- cord-331343-qzvwwca9 132 31 collagen collagen NN cord-331343-qzvwwca9 132 32 and and CC cord-331343-qzvwwca9 132 33 fibril fibril NN cord-331343-qzvwwca9 132 34 structures structure NNS cord-331343-qzvwwca9 132 35 in in IN cord-331343-qzvwwca9 132 36 mesenchymal mesenchymal JJ cord-331343-qzvwwca9 132 37 tissues tissue NNS cord-331343-qzvwwca9 132 38 . . . cord-331343-qzvwwca9 133 1 4 4 LS cord-331343-qzvwwca9 133 2 Simultaneous simultaneous JJ cord-331343-qzvwwca9 133 3 activation activation NN cord-331343-qzvwwca9 133 4 of of IN cord-331343-qzvwwca9 133 5 both both DT cord-331343-qzvwwca9 133 6 type type NN cord-331343-qzvwwca9 133 7 - - : cord-331343-qzvwwca9 133 8 I i NN cord-331343-qzvwwca9 133 9 and and CC cord-331343-qzvwwca9 133 10 type type NN cord-331343-qzvwwca9 133 11 - - HYPH cord-331343-qzvwwca9 133 12 III iii CD cord-331343-qzvwwca9 133 13 collagens collagen NNS cord-331343-qzvwwca9 133 14 with with IN cord-331343-qzvwwca9 133 15 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 133 16 expression expression NN cord-331343-qzvwwca9 133 17 was be VBD cord-331343-qzvwwca9 133 18 also also RB cord-331343-qzvwwca9 133 19 reported report VBN cord-331343-qzvwwca9 133 20 in in IN cord-331343-qzvwwca9 133 21 HSCs hscs NN cord-331343-qzvwwca9 133 22 during during IN cord-331343-qzvwwca9 133 23 carbon carbon NN cord-331343-qzvwwca9 133 24 tetrachloride tetrachloride NN cord-331343-qzvwwca9 133 25 ( ( -LRB- cord-331343-qzvwwca9 133 26 CCl CCl NNS cord-331343-qzvwwca9 133 27 4 4 CD cord-331343-qzvwwca9 133 28 ) ) -RRB- cord-331343-qzvwwca9 133 29 -induced -induce VBN cord-331343-qzvwwca9 133 30 liver liver NN cord-331343-qzvwwca9 133 31 fibrosis fibrosis NN cord-331343-qzvwwca9 133 32 in in IN cord-331343-qzvwwca9 133 33 rats rat NNS cord-331343-qzvwwca9 133 34 . . . cord-331343-qzvwwca9 134 1 5 5 LS cord-331343-qzvwwca9 135 1 Conversely conversely RB cord-331343-qzvwwca9 135 2 , , , cord-331343-qzvwwca9 135 3 the the DT cord-331343-qzvwwca9 135 4 constitutive constitutive JJ cord-331343-qzvwwca9 135 5 overexpression overexpression NN cord-331343-qzvwwca9 135 6 of of IN cord-331343-qzvwwca9 135 7 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 135 8 promotes promote VBZ cord-331343-qzvwwca9 135 9 the the DT cord-331343-qzvwwca9 135 10 secretion secretion NN cord-331343-qzvwwca9 135 11 of of IN cord-331343-qzvwwca9 135 12 collagens collagen NNS cord-331343-qzvwwca9 135 13 in in IN cord-331343-qzvwwca9 135 14 vascular vascular JJ cord-331343-qzvwwca9 135 15 smooth smooth JJ cord-331343-qzvwwca9 135 16 muscle muscle NN cord-331343-qzvwwca9 135 17 cells cell NNS cord-331343-qzvwwca9 135 18 . . . cord-331343-qzvwwca9 136 1 6 6 CD cord-331343-qzvwwca9 137 1 As as IN cord-331343-qzvwwca9 137 2 a a DT cord-331343-qzvwwca9 137 3 molecular molecular JJ cord-331343-qzvwwca9 137 4 chaperone chaperone NN cord-331343-qzvwwca9 137 5 , , , cord-331343-qzvwwca9 137 6 HSP47 HSP47 NNP cord-331343-qzvwwca9 137 7 binds bind VBZ cord-331343-qzvwwca9 137 8 closely closely RB cord-331343-qzvwwca9 137 9 to to TO cord-331343-qzvwwca9 137 10 procollagen procollagen VB cord-331343-qzvwwca9 137 11 in in IN cord-331343-qzvwwca9 137 12 the the DT cord-331343-qzvwwca9 137 13 endoplasmic endoplasmic NN cord-331343-qzvwwca9 137 14 reticulum reticulum NN cord-331343-qzvwwca9 137 15 , , , cord-331343-qzvwwca9 137 16 but but CC cord-331343-qzvwwca9 137 17 dissociates dissociate VBZ cord-331343-qzvwwca9 137 18 from from IN cord-331343-qzvwwca9 137 19 it -PRON- PRP cord-331343-qzvwwca9 137 20 in in IN cord-331343-qzvwwca9 137 21 the the DT cord-331343-qzvwwca9 137 22 Golgi Golgi NNP cord-331343-qzvwwca9 137 23 complex complex NN cord-331343-qzvwwca9 137 24 to to TO cord-331343-qzvwwca9 137 25 allow allow VB cord-331343-qzvwwca9 137 26 triple triple JJ cord-331343-qzvwwca9 137 27 helix helix NN cord-331343-qzvwwca9 137 28 formation formation NN cord-331343-qzvwwca9 137 29 . . . cord-331343-qzvwwca9 138 1 7 7 CD cord-331343-qzvwwca9 139 1 Based base VBN cord-331343-qzvwwca9 139 2 on on IN cord-331343-qzvwwca9 139 3 these these DT cord-331343-qzvwwca9 139 4 properties property NNS cord-331343-qzvwwca9 139 5 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 139 6 has have VBZ cord-331343-qzvwwca9 139 7 been be VBN cord-331343-qzvwwca9 139 8 suggested suggest VBN cord-331343-qzvwwca9 139 9 as as IN cord-331343-qzvwwca9 139 10 plausible plausible JJ cord-331343-qzvwwca9 139 11 molecular molecular JJ cord-331343-qzvwwca9 139 12 target target NN cord-331343-qzvwwca9 139 13 to to TO cord-331343-qzvwwca9 139 14 interfere interfere VB cord-331343-qzvwwca9 139 15 with with IN cord-331343-qzvwwca9 139 16 fibrogenesis fibrogenesis NN cord-331343-qzvwwca9 139 17 ( ( -LRB- cord-331343-qzvwwca9 139 18 Fig Fig NNP cord-331343-qzvwwca9 139 19 . . NNP cord-331343-qzvwwca9 139 20 1 1 CD cord-331343-qzvwwca9 139 21 ) ) -RRB- cord-331343-qzvwwca9 139 22 . . . cord-331343-qzvwwca9 140 1 Initial initial JJ cord-331343-qzvwwca9 140 2 proof proof NN cord-331343-qzvwwca9 140 3 - - HYPH cord-331343-qzvwwca9 140 4 of of IN cord-331343-qzvwwca9 140 5 - - HYPH cord-331343-qzvwwca9 140 6 concept concept NN cord-331343-qzvwwca9 140 7 was be VBD cord-331343-qzvwwca9 140 8 obtained obtain VBN cord-331343-qzvwwca9 140 9 in in IN cord-331343-qzvwwca9 140 10 experimental experimental JJ cord-331343-qzvwwca9 140 11 models model NNS cord-331343-qzvwwca9 140 12 , , , cord-331343-qzvwwca9 140 13 demonstrating demonstrate VBG cord-331343-qzvwwca9 140 14 that that DT cord-331343-qzvwwca9 140 15 small small JJ cord-331343-qzvwwca9 140 16 interfering interfere VBG cord-331343-qzvwwca9 140 17 RNA RNA NNP cord-331343-qzvwwca9 140 18 ( ( -LRB- cord-331343-qzvwwca9 140 19 siRNA siRNA NNP cord-331343-qzvwwca9 140 20 ) ) -RRB- cord-331343-qzvwwca9 140 21 targeting target VBG cord-331343-qzvwwca9 140 22 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 140 23 inhibited inhibit VBD cord-331343-qzvwwca9 140 24 the the DT cord-331343-qzvwwca9 140 25 expression expression NN cord-331343-qzvwwca9 140 26 of of IN cord-331343-qzvwwca9 140 27 type type NN cord-331343-qzvwwca9 140 28 - - : cord-331343-qzvwwca9 140 29 I i NN cord-331343-qzvwwca9 140 30 collagen collagen NN cord-331343-qzvwwca9 140 31 and and CC cord-331343-qzvwwca9 140 32 the the DT cord-331343-qzvwwca9 140 33 formation formation NN cord-331343-qzvwwca9 140 34 of of IN cord-331343-qzvwwca9 140 35 scar scar NN cord-331343-qzvwwca9 140 36 tissue tissue NN cord-331343-qzvwwca9 140 37 . . . cord-331343-qzvwwca9 141 1 8 8 CD cord-331343-qzvwwca9 141 2 , , , cord-331343-qzvwwca9 141 3 9 9 CD cord-331343-qzvwwca9 142 1 The the DT cord-331343-qzvwwca9 142 2 study study NN cord-331343-qzvwwca9 142 3 by by IN cord-331343-qzvwwca9 142 4 Sato Sato NNP cord-331343-qzvwwca9 142 5 et et FW cord-331343-qzvwwca9 142 6 al al NNP cord-331343-qzvwwca9 142 7 . . . cord-331343-qzvwwca9 143 1 10 10 CD cord-331343-qzvwwca9 143 2 targets target NNS cord-331343-qzvwwca9 143 3 siRNA siRNA NNP cord-331343-qzvwwca9 143 4 directed direct VBN cord-331343-qzvwwca9 143 5 against against IN cord-331343-qzvwwca9 143 6 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 143 7 to to IN cord-331343-qzvwwca9 143 8 HSCs HSCs NNP cord-331343-qzvwwca9 143 9 . . . cord-331343-qzvwwca9 144 1 The the DT cord-331343-qzvwwca9 144 2 authors author NNS cord-331343-qzvwwca9 144 3 used use VBD cord-331343-qzvwwca9 144 4 a a DT cord-331343-qzvwwca9 144 5 key key JJ cord-331343-qzvwwca9 144 6 feature feature NN cord-331343-qzvwwca9 144 7 of of IN cord-331343-qzvwwca9 144 8 HSCs hscs NN cord-331343-qzvwwca9 144 9 , , , cord-331343-qzvwwca9 144 10 that that RB cord-331343-qzvwwca9 144 11 is is RB cord-331343-qzvwwca9 144 12 , , , cord-331343-qzvwwca9 144 13 uptake uptake NN cord-331343-qzvwwca9 144 14 and and CC cord-331343-qzvwwca9 144 15 storage storage NN cord-331343-qzvwwca9 144 16 of of IN cord-331343-qzvwwca9 144 17 vitamin vitamin NN cord-331343-qzvwwca9 144 18 A a NN cord-331343-qzvwwca9 144 19 , , , cord-331343-qzvwwca9 144 20 highlighted highlight VBN cord-331343-qzvwwca9 144 21 by by IN cord-331343-qzvwwca9 144 22 Hans Hans NNP cord-331343-qzvwwca9 144 23 Popper Popper NNP cord-331343-qzvwwca9 144 24 more more JJR cord-331343-qzvwwca9 144 25 than than IN cord-331343-qzvwwca9 144 26 60 60 CD cord-331343-qzvwwca9 144 27 years year NNS cord-331343-qzvwwca9 144 28 ago ago RB cord-331343-qzvwwca9 144 29 . . . cord-331343-qzvwwca9 145 1 11 11 CD cord-331343-qzvwwca9 145 2 Sato Sato NNP cord-331343-qzvwwca9 145 3 et et FW cord-331343-qzvwwca9 145 4 al al NNP cord-331343-qzvwwca9 145 5 . . . cord-331343-qzvwwca9 146 1 prepared prepared JJ cord-331343-qzvwwca9 146 2 retinol retinol NN cord-331343-qzvwwca9 146 3 - - HYPH cord-331343-qzvwwca9 146 4 coupled couple VBN cord-331343-qzvwwca9 146 5 liposomes liposome NNS cord-331343-qzvwwca9 146 6 carrying carry VBG cord-331343-qzvwwca9 146 7 siRNA siRNA NNP cord-331343-qzvwwca9 146 8 against against IN cord-331343-qzvwwca9 146 9 Hsp47 Hsp47 NNP cord-331343-qzvwwca9 146 10 and and CC cord-331343-qzvwwca9 146 11 demonstrated demonstrate VBD cord-331343-qzvwwca9 146 12 binding binding NN cord-331343-qzvwwca9 146 13 of of IN cord-331343-qzvwwca9 146 14 retinol retinol NN cord-331343-qzvwwca9 146 15 binding bind VBG cord-331343-qzvwwca9 146 16 protein protein NN cord-331343-qzvwwca9 146 17 ( ( -LRB- cord-331343-qzvwwca9 146 18 RBP RBP NNP cord-331343-qzvwwca9 146 19 ) ) -RRB- cord-331343-qzvwwca9 146 20 to to IN cord-331343-qzvwwca9 146 21 these these DT cord-331343-qzvwwca9 146 22 liposomes liposome NNS cord-331343-qzvwwca9 146 23 ( ( -LRB- cord-331343-qzvwwca9 146 24 via via IN cord-331343-qzvwwca9 146 25 gel gel NN cord-331343-qzvwwca9 146 26 filtration filtration NN cord-331343-qzvwwca9 146 27 ) ) -RRB- cord-331343-qzvwwca9 146 28 , , , cord-331343-qzvwwca9 146 29 receptor receptor NN cord-331343-qzvwwca9 146 30 - - HYPH cord-331343-qzvwwca9 146 31 mediated mediate VBN cord-331343-qzvwwca9 146 32 uptake uptake NN cord-331343-qzvwwca9 146 33 of of IN cord-331343-qzvwwca9 146 34 the the DT cord-331343-qzvwwca9 146 35 RBP rbp NN cord-331343-qzvwwca9 146 36 - - HYPH cord-331343-qzvwwca9 146 37 coupled couple VBN cord-331343-qzvwwca9 146 38 complexes complex NNS cord-331343-qzvwwca9 146 39 by by IN cord-331343-qzvwwca9 146 40 HSCs hsc NNS cord-331343-qzvwwca9 146 41 in in IN cord-331343-qzvwwca9 146 42 vitro vitro FW cord-331343-qzvwwca9 146 43 ( ( -LRB- cord-331343-qzvwwca9 146 44 via via IN cord-331343-qzvwwca9 146 45 flow flow NN cord-331343-qzvwwca9 146 46 cytometry cytometry NN cord-331343-qzvwwca9 146 47 ) ) -RRB- cord-331343-qzvwwca9 146 48 , , , cord-331343-qzvwwca9 146 49 and and CC cord-331343-qzvwwca9 146 50 suppression suppression NN cord-331343-qzvwwca9 146 51 of of IN cord-331343-qzvwwca9 146 52 cellular cellular JJ cord-331343-qzvwwca9 146 53 collagen collagen NN cord-331343-qzvwwca9 146 54 secretion secretion NN cord-331343-qzvwwca9 146 55 ( ( -LRB- cord-331343-qzvwwca9 146 56 via via IN cord-331343-qzvwwca9 146 57 Sirius Sirius NNP cord-331343-qzvwwca9 146 58 red red JJ cord-331343-qzvwwca9 146 59 binding bind VBG cord-331343-qzvwwca9 146 60 assays).Using assays).use VBG cord-331343-qzvwwca9 146 61 three three CD cord-331343-qzvwwca9 146 62 different different JJ cord-331343-qzvwwca9 146 63 models model NNS cord-331343-qzvwwca9 146 64 of of IN cord-331343-qzvwwca9 146 65 liver liver NN cord-331343-qzvwwca9 146 66 fibrosis fibrosis NN cord-331343-qzvwwca9 146 67 ( ( -LRB- cord-331343-qzvwwca9 146 68 dimethylnitrosamine dimethylnitrosamine NNP cord-331343-qzvwwca9 146 69 [ [ -LRB- cord-331343-qzvwwca9 146 70 DMN DMN NNP cord-331343-qzvwwca9 146 71 ] ] -RRB- cord-331343-qzvwwca9 146 72 , , , cord-331343-qzvwwca9 146 73 CCl CCl NNS cord-331343-qzvwwca9 146 74 4 4 CD cord-331343-qzvwwca9 146 75 , , , cord-331343-qzvwwca9 146 76 and and CC cord-331343-qzvwwca9 146 77 bile bile NN cord-331343-qzvwwca9 146 78 duct duct NN cord-331343-qzvwwca9 146 79 ligation ligation NN cord-331343-qzvwwca9 146 80 ) ) -RRB- cord-331343-qzvwwca9 146 81 , , , cord-331343-qzvwwca9 146 82 the the DT cord-331343-qzvwwca9 146 83 study study NN cord-331343-qzvwwca9 146 84 assessed assess VBD cord-331343-qzvwwca9 146 85 the the DT cord-331343-qzvwwca9 146 86 antifibrotic antifibrotic JJ cord-331343-qzvwwca9 146 87 properties property NNS cord-331343-qzvwwca9 146 88 of of IN cord-331343-qzvwwca9 146 89 the the DT cord-331343-qzvwwca9 146 90 siRNAcarrying sirnacarrying NN cord-331343-qzvwwca9 146 91 liposomes liposome NNS cord-331343-qzvwwca9 146 92 in in IN cord-331343-qzvwwca9 146 93 vivo vivo NN cord-331343-qzvwwca9 146 94 at at IN cord-331343-qzvwwca9 146 95 comparatively comparatively RB cord-331343-qzvwwca9 146 96 low low JJ cord-331343-qzvwwca9 146 97 doses dose NNS cord-331343-qzvwwca9 146 98 of of IN cord-331343-qzvwwca9 146 99 0.75 0.75 CD cord-331343-qzvwwca9 146 100 mg mg NNP cord-331343-qzvwwca9 146 101 / / SYM cord-331343-qzvwwca9 146 102 kg kg NN cord-331343-qzvwwca9 146 103 body body NN cord-331343-qzvwwca9 146 104 weight weight NN cord-331343-qzvwwca9 146 105 . . . cord-331343-qzvwwca9 147 1 As as IN cord-331343-qzvwwca9 147 2 shown show VBN cord-331343-qzvwwca9 147 3 by by IN cord-331343-qzvwwca9 147 4 immunofluorescence immunofluorescence NN cord-331343-qzvwwca9 147 5 and and CC cord-331343-qzvwwca9 147 6 fluorescence fluorescence NN cord-331343-qzvwwca9 147 7 - - HYPH cord-331343-qzvwwca9 147 8 activated activate VBN cord-331343-qzvwwca9 147 9 cell cell NN cord-331343-qzvwwca9 147 10 sorting sorting NN cord-331343-qzvwwca9 147 11 analysis analysis NN cord-331343-qzvwwca9 147 12 of of IN cord-331343-qzvwwca9 147 13 isolated isolated JJ cord-331343-qzvwwca9 147 14 liver liver NN cord-331343-qzvwwca9 147 15 cells cell NNS cord-331343-qzvwwca9 147 16 , , , cord-331343-qzvwwca9 147 17 the the DT cord-331343-qzvwwca9 147 18 liposomes liposome NNS cord-331343-qzvwwca9 147 19 were be VBD cord-331343-qzvwwca9 147 20 predominantly predominantly RB