id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323568-s0wmll4q	Shang, Jian	Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins	2018-04-23		.txt	text/plain	7464	452	60	Specifically, among different genera, the two domains of S1, the N-terminal domain (S1-NTD) and C-terminal domain (S1-CTD), diverge from simpler tertiary structures and quaternary packing to more complex ones, leading to different functions of the spikes in receptor usage and membrane fusion. The initial model of IBV spike ectodomain was obtained by fitting the seven parts (S1-NTD, S1-CTD, two parts of SD1, two parts of SD2, and S2) of the porcine delta coronavirus spike structure (PDB ID: 6B7N) individually into the cryo-EM density map of IBV spike using UCSF Chimera [41] and Coot [42] . Based on the structural similarity between the S1-NTDs from different coronavirus genera, the sugar-binding site in IBV S1-NTD might also be located in the pocket formed between the core structure and the partial ceiling (Figs 2B and 3C) . The putative RBMs of IBV S1-CTD and the partial ceiling Structure, function, and evolution of IBV spike protein of IBV S1-NTD are both involved in the cross-subunit packing.	./cache/cord-323568-s0wmll4q.txt	./txt/cord-323568-s0wmll4q.txt