id author title date pages extension mime words sentences flesch summary cache txt cord-355703-l9l4ybfn Zhao, Fei Genomic Characteristics and Changes of Avian Infectious Bronchitis Virus Strain CK/CH/LDL/97I after Serial Passages in Chicken Embryos 2014-08-29 .txt text/plain 5859 300 49 title: Genomic Characteristics and Changes of Avian Infectious Bronchitis Virus Strain CK/CH/LDL/97I after Serial Passages in Chicken Embryos To identify specific sequence changes responsible for adaptation of the field IBV isolate to chicken embryonic tissue and subsequent attenuation, the whole viral genome of the IBV P5 pathogenic parental CK/CH/LDL/97I strain was sequenced and compared with the attenuated, P115 level virus, to provide a better understanding of the relationship between the genomic differences and related characteristics of the pathogenic and attenuated viruses. Limited information is currently available regarding the pathogenicity of CK/CH/ LDL/97I-type IBV strains and embryo-passaged, attenuated P115 in the chicken oviduct. Altered pathogenicity, immunogenicity, tissue tropism and 3 ′ -7 kb region sequence of an avian infectious bronchitis coronavirus strain after serial passage in embryos Sequence changes of infectious bronchitis virus isolates in the 3 ′ -7.3 kb of the genome after attenuating passage in embryonated eggs ./cache/cord-355703-l9l4ybfn.txt ./txt/cord-355703-l9l4ybfn.txt