id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001536-ta1i0ata	Nair, Girish B	Year in review 2013: critical care - respiratory infections	2014-10-29		.txt	text/plain	8891	335	37	New studies have suggested strategies to identify patients at risk for resistant pathogen infection and therapies that optimize efficacy, without the overuse of broad-spectrum therapy in patients with healthcare-associated pneumonia. Infections, mostly nosocomial, are a major cause of mortality in hospitalized patients related to an increased risk of infection with multi-drug resistant (MDR) pathogens and the widespread use of indiscriminate broad-spectrum antibiotics. In a study including 519 patients with CAP and 419 with HCAP, the authors compared the performance of Pneumonia Severity Index (PSI) and CURB-65 risk scores for predicting 30-day mortality [20] . Maruyama and colleagues [23] , in a prospective study of 425 patients (CAP = 124, HCAP = 321), applied a therapeutic algorithm based on the presence of MDR risk factors (immunosuppression, hospitalization within the last 90 days, poor functional status indicated by a Barthel Index score <50, and antibiotic therapy within the past 6 months) and severity of illness (need for ICU admission or requiring MV) to determine its impact on outcomes.	./cache/cord-001536-ta1i0ata.txt	./txt/cord-001536-ta1i0ata.txt