id author title date pages extension mime words sentences flesch summary cache txt cord-003701-i70ztypg Chow, Eric J. Influenza virus-related critical illness: prevention, diagnosis, treatment 2019-06-12 .txt text/plain 6869 320 25 Based upon observational data that suggest harms, adjunctive corticosteroid treatment is currently not recommended for children or adults hospitalized with influenza, including critically ill patients, unless clinically indicated for another reason, such as treatment of asthma or COPD exacerbation, or septic shock. No completed randomized, placebo-controlled trials of antiviral treatment have been conducted in hospitalized influenza patients to establish the efficacy of oseltamivir or other NAIs. A number of observational studies have reported clinical benefit of neuraminidase inhibitors in hospitalized patients, including reduction in duration of hospitalization and risk of death, including in ICU patients [67] [68] [69] [70] [71] [72] [73] [74] . A cohort study of early versus late oseltamivir treatment reported a significant reduction in mortality and median duration of ICU hospitalization in severely ill patients with influenza A(H3N2), but not A(H1N1pdm09) or B virus infection in Greece [78] . ./cache/cord-003701-i70ztypg.txt ./txt/cord-003701-i70ztypg.txt