id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254818-dzsyuwpy	Bangash, Mansoor N	COVID-19 recovery: potential treatments for post-intensive care syndrome	2020-10-12		.txt	text/plain	1406	66	31	In the MANAGE trial, 8 a population having non-cardiac surgery, which overlaps COVID-19 recovery: potential treatments for post-intensive care syndrome and shares similarities with the PICS population through the presence of non-ischaemic myocardial injuries, was found to have reduced cardiovascular morbidity at follow-up when treated with the antithrombotic dabigatran; further trials of dabigatran in patients with PICS are warranted. We suggest that the research pathway for such trials should be based on prognostic enrichment through clinical and cardiovascular or immune biomarker profiles, and initially use established drugs that modify cardiometabolic risk in ICU survivors who might not have traditionally recognised cardiovascular risk factors, through randomised controlled trials led by intensive care specialists. Post-intensive care syndrome (PICS) often occurs after prolonged critical illnesses, such as COVID-19-associated acute respiratory distress syndrome, and involves persistent inflammation, immunosuppression, and catabolism.	./cache/cord-254818-dzsyuwpy.txt	./txt/cord-254818-dzsyuwpy.txt