id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267296-u4svwcpt	Rauch, Antoine	Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19	2020-11-10		.txt	text/plain	1318	76	37	4 We further investigated the association of plasma-induced cytotoxicity with levels of circulating biomarkers related to organ dysfunction (Pao 2 [partial pressure of oxygen in arterial blood]/Fio 2 [fraction of inspired oxygen], widely used as an indicator of oxygenation requirements, lactate dehydrogenase, creatinine, and aspartate transaminase), endothelial damage (von Willebrand factor antigen; ADAMTS13; plasminogen activator inhibitor-1; syndecan-1), tissue injury (cell-free DNA, a damage-associated molecular patterns marker), and levels of circulating cytokines related to the activation of innate (interleukin [IL]-6 and tumor necrosis factor-α) and adaptative immune cell responses (soluble IL-2 receptor). Overall, the degree of vascular endothelial cell injury induced by plasma sampled from patients with COVID-19 correlated to both clinical illness severity at admission and the levels of biomarkers related to endothelial injury, tissue injury, and proinflammatory cytokines. Our data shed new light on the pathophysiology of COVID-19 by demonstrating the direct and rapid cytotoxic effect of plasma collected from critically ill patients on vascular endothelial cells.	./cache/cord-267296-u4svwcpt.txt	./txt/cord-267296-u4svwcpt.txt