id sid tid token lemma pos cord-011418-hy8xmtiq 1 1 key key NN cord-011418-hy8xmtiq 1 2 : : : cord-011418-hy8xmtiq 2 1 cord-011418-hy8xmtiq cord-011418-hy8xmtiq CD cord-011418-hy8xmtiq 3 1 authors author NNS cord-011418-hy8xmtiq 3 2 : : : cord-011418-hy8xmtiq 3 3 Walz Walz NNP cord-011418-hy8xmtiq 3 4 , , , cord-011418-hy8xmtiq 3 5 Alice Alice NNP cord-011418-hy8xmtiq 3 6 ; ; : cord-011418-hy8xmtiq 3 7 Canter Canter NNP cord-011418-hy8xmtiq 3 8 , , , cord-011418-hy8xmtiq 3 9 Marguerite Marguerite NNP cord-011418-hy8xmtiq 3 10 Orsi Orsi NNP cord-011418-hy8xmtiq 3 11 ; ; : cord-011418-hy8xmtiq 3 12 Betters Betters NNP cord-011418-hy8xmtiq 3 13 , , , cord-011418-hy8xmtiq 4 1 Kristina Kristina NNP cord-011418-hy8xmtiq 4 2 title title NN cord-011418-hy8xmtiq 4 3 : : : cord-011418-hy8xmtiq 4 4 The the DT cord-011418-hy8xmtiq 4 5 ICU ICU NNP cord-011418-hy8xmtiq 4 6 Liberation Liberation NNP cord-011418-hy8xmtiq 4 7 Bundle Bundle NNP cord-011418-hy8xmtiq 4 8 and and CC cord-011418-hy8xmtiq 4 9 Strategies Strategies NNPS cord-011418-hy8xmtiq 4 10 for for IN cord-011418-hy8xmtiq 4 11 Implementation Implementation NNP cord-011418-hy8xmtiq 4 12 in in IN cord-011418-hy8xmtiq 4 13 Pediatrics Pediatrics NNP cord-011418-hy8xmtiq 4 14 date date NN cord-011418-hy8xmtiq 4 15 : : : cord-011418-hy8xmtiq 4 16 2020 2020 CD cord-011418-hy8xmtiq 4 17 - - HYPH cord-011418-hy8xmtiq 4 18 05 05 CD cord-011418-hy8xmtiq 4 19 - - HYPH cord-011418-hy8xmtiq 4 20 16 16 CD cord-011418-hy8xmtiq 4 21 journal journal NN cord-011418-hy8xmtiq 4 22 : : : cord-011418-hy8xmtiq 5 1 Curr Curr NNP cord-011418-hy8xmtiq 5 2 Pediatr Pediatr NNP cord-011418-hy8xmtiq 5 3 Rep Rep NNP cord-011418-hy8xmtiq 5 4 DOI DOI NNP cord-011418-hy8xmtiq 5 5 : : : cord-011418-hy8xmtiq 5 6 10.1007 10.1007 CD cord-011418-hy8xmtiq 5 7 / / SYM cord-011418-hy8xmtiq 5 8 s40124 s40124 CD cord-011418-hy8xmtiq 5 9 - - HYPH cord-011418-hy8xmtiq 5 10 020 020 CD cord-011418-hy8xmtiq 5 11 - - HYPH cord-011418-hy8xmtiq 5 12 00216 00216 CD cord-011418-hy8xmtiq 5 13 - - SYM cord-011418-hy8xmtiq 5 14 7 7 CD cord-011418-hy8xmtiq 5 15 sha sha NN cord-011418-hy8xmtiq 5 16 : : : cord-011418-hy8xmtiq 6 1 50bd3f1c51c163684ee9aaec55711793aa8c6dc5 50bd3f1c51c163684ee9aaec55711793aa8c6dc5 : cord-011418-hy8xmtiq 6 2 doc_id doc_id CD cord-011418-hy8xmtiq 6 3 : : : cord-011418-hy8xmtiq 6 4 11418 11418 CD cord-011418-hy8xmtiq 6 5 cord_uid cord_uid NNS cord-011418-hy8xmtiq 6 6 : : : cord-011418-hy8xmtiq 7 1 hy8xmtiq hy8xmtiq NNP cord-011418-hy8xmtiq 7 2 PURPOSE purpose NN cord-011418-hy8xmtiq 7 3 OF of IN cord-011418-hy8xmtiq 7 4 REVIEW review NN cord-011418-hy8xmtiq 8 1 : : : cord-011418-hy8xmtiq 8 2 We -PRON- PRP cord-011418-hy8xmtiq 8 3 briefly briefly RB cord-011418-hy8xmtiq 8 4 review review VBP cord-011418-hy8xmtiq 8 5 post post JJ cord-011418-hy8xmtiq 8 6 - - JJ cord-011418-hy8xmtiq 8 7 intensive intensive JJ cord-011418-hy8xmtiq 8 8 care care NN cord-011418-hy8xmtiq 8 9 syndrome syndrome NN cord-011418-hy8xmtiq 8 10 ( ( -LRB- cord-011418-hy8xmtiq 8 11 PICS PICS NNP cord-011418-hy8xmtiq 8 12 ) ) -RRB- cord-011418-hy8xmtiq 8 13 and and CC cord-011418-hy8xmtiq 8 14 the the DT cord-011418-hy8xmtiq 8 15 morbidities morbidity NNS cord-011418-hy8xmtiq 8 16 associated associate VBN cord-011418-hy8xmtiq 8 17 with with IN cord-011418-hy8xmtiq 8 18 critical critical JJ cord-011418-hy8xmtiq 8 19 illness illness NN cord-011418-hy8xmtiq 8 20 that that WDT cord-011418-hy8xmtiq 8 21 led lead VBD cord-011418-hy8xmtiq 8 22 to to IN cord-011418-hy8xmtiq 8 23 the the DT cord-011418-hy8xmtiq 8 24 intensive intensive JJ cord-011418-hy8xmtiq 8 25 care care NN cord-011418-hy8xmtiq 8 26 unit unit NN cord-011418-hy8xmtiq 8 27 ( ( -LRB- cord-011418-hy8xmtiq 8 28 ICU ICU NNP cord-011418-hy8xmtiq 8 29 ) ) -RRB- cord-011418-hy8xmtiq 8 30 liberation liberation NN cord-011418-hy8xmtiq 8 31 movement movement NN cord-011418-hy8xmtiq 8 32 . . . cord-011418-hy8xmtiq 9 1 We -PRON- PRP cord-011418-hy8xmtiq 9 2 review review VBP cord-011418-hy8xmtiq 9 3 each each DT cord-011418-hy8xmtiq 9 4 element element NN cord-011418-hy8xmtiq 9 5 of of IN cord-011418-hy8xmtiq 9 6 the the DT cord-011418-hy8xmtiq 9 7 ICU ICU NNP cord-011418-hy8xmtiq 9 8 liberation liberation NN cord-011418-hy8xmtiq 9 9 bundle bundle NN cord-011418-hy8xmtiq 9 10 , , , cord-011418-hy8xmtiq 9 11 including include VBG cord-011418-hy8xmtiq 9 12 pediatric pediatric JJ cord-011418-hy8xmtiq 9 13 support support NN cord-011418-hy8xmtiq 9 14 data datum NNS cord-011418-hy8xmtiq 9 15 , , , cord-011418-hy8xmtiq 9 16 as as RB cord-011418-hy8xmtiq 9 17 well well RB cord-011418-hy8xmtiq 9 18 as as IN cord-011418-hy8xmtiq 9 19 tips tip NNS cord-011418-hy8xmtiq 9 20 and and CC cord-011418-hy8xmtiq 9 21 strategies strategy NNS cord-011418-hy8xmtiq 9 22 for for IN cord-011418-hy8xmtiq 9 23 implementation implementation NN cord-011418-hy8xmtiq 9 24 in in IN cord-011418-hy8xmtiq 9 25 a a DT cord-011418-hy8xmtiq 9 26 pediatric pediatric JJ cord-011418-hy8xmtiq 9 27 ICU ICU NNP cord-011418-hy8xmtiq 9 28 ( ( -LRB- cord-011418-hy8xmtiq 9 29 PICU PICU NNP cord-011418-hy8xmtiq 9 30 ) ) -RRB- cord-011418-hy8xmtiq 9 31 setting setting NN cord-011418-hy8xmtiq 9 32 . . . cord-011418-hy8xmtiq 10 1 RECENT recent JJ cord-011418-hy8xmtiq 10 2 FINDINGS finding NNS cord-011418-hy8xmtiq 10 3 : : : cord-011418-hy8xmtiq 11 1 Numerous numerous JJ cord-011418-hy8xmtiq 11 2 studies study NNS cord-011418-hy8xmtiq 11 3 have have VBP cord-011418-hy8xmtiq 11 4 found find VBN cord-011418-hy8xmtiq 11 5 children child NNS cord-011418-hy8xmtiq 11 6 have have VB cord-011418-hy8xmtiq 11 7 cognitive cognitive JJ cord-011418-hy8xmtiq 11 8 , , , cord-011418-hy8xmtiq 11 9 physical physical JJ cord-011418-hy8xmtiq 11 10 , , , cord-011418-hy8xmtiq 11 11 and and CC cord-011418-hy8xmtiq 11 12 psychiatric psychiatric JJ cord-011418-hy8xmtiq 11 13 deficits deficit NNS cord-011418-hy8xmtiq 11 14 after after IN cord-011418-hy8xmtiq 11 15 a a DT cord-011418-hy8xmtiq 11 16 PICU PICU NNP cord-011418-hy8xmtiq 11 17 stay stay NN cord-011418-hy8xmtiq 11 18 . . . cord-011418-hy8xmtiq 12 1 The the DT cord-011418-hy8xmtiq 12 2 effects effect NNS cord-011418-hy8xmtiq 12 3 of of IN cord-011418-hy8xmtiq 12 4 the the DT cord-011418-hy8xmtiq 12 5 full full JJ cord-011418-hy8xmtiq 12 6 ICU ICU NNP cord-011418-hy8xmtiq 12 7 liberation liberation NN cord-011418-hy8xmtiq 12 8 bundle bundle NN cord-011418-hy8xmtiq 12 9 in in IN cord-011418-hy8xmtiq 12 10 children child NNS cord-011418-hy8xmtiq 12 11 have have VBP cord-011418-hy8xmtiq 12 12 not not RB cord-011418-hy8xmtiq 12 13 been be VBN cord-011418-hy8xmtiq 12 14 published publish VBN cord-011418-hy8xmtiq 12 15 , , , cord-011418-hy8xmtiq 12 16 but but CC cord-011418-hy8xmtiq 12 17 in in IN cord-011418-hy8xmtiq 12 18 adults adult NNS cord-011418-hy8xmtiq 12 19 , , , cord-011418-hy8xmtiq 12 20 bundle bundle NN cord-011418-hy8xmtiq 12 21 implementation implementation NN cord-011418-hy8xmtiq 12 22 ( ( -LRB- cord-011418-hy8xmtiq 12 23 even even RB cord-011418-hy8xmtiq 12 24 partial partial JJ cord-011418-hy8xmtiq 12 25 ) ) -RRB- cord-011418-hy8xmtiq 12 26 resulted result VBD cord-011418-hy8xmtiq 12 27 in in IN cord-011418-hy8xmtiq 12 28 significant significant JJ cord-011418-hy8xmtiq 12 29 improvement improvement NN cord-011418-hy8xmtiq 12 30 in in IN cord-011418-hy8xmtiq 12 31 survival survival NN cord-011418-hy8xmtiq 12 32 , , , cord-011418-hy8xmtiq 12 33 mechanical mechanical JJ cord-011418-hy8xmtiq 12 34 ventilation ventilation NN cord-011418-hy8xmtiq 12 35 use use NN cord-011418-hy8xmtiq 12 36 , , , cord-011418-hy8xmtiq 12 37 coma coma NN cord-011418-hy8xmtiq 12 38 , , , cord-011418-hy8xmtiq 12 39 delirium delirium NN cord-011418-hy8xmtiq 12 40 , , , cord-011418-hy8xmtiq 12 41 restraint restraint NN cord-011418-hy8xmtiq 12 42 - - HYPH cord-011418-hy8xmtiq 12 43 free free JJ cord-011418-hy8xmtiq 12 44 care care NN cord-011418-hy8xmtiq 12 45 , , , cord-011418-hy8xmtiq 12 46 ICU ICU NNP cord-011418-hy8xmtiq 12 47 readmissions readmission NNS cord-011418-hy8xmtiq 12 48 , , , cord-011418-hy8xmtiq 12 49 and and CC cord-011418-hy8xmtiq 12 50 post post JJ cord-011418-hy8xmtiq 12 51 - - JJ cord-011418-hy8xmtiq 12 52 ICU icu JJ cord-011418-hy8xmtiq 12 53 discharge discharge NN cord-011418-hy8xmtiq 12 54 disposition disposition NN cord-011418-hy8xmtiq 12 55 . . . cord-011418-hy8xmtiq 13 1 SUMMARY summary NN cord-011418-hy8xmtiq 13 2 : : : cord-011418-hy8xmtiq 14 1 Although although IN cord-011418-hy8xmtiq 14 2 initially initially RB cord-011418-hy8xmtiq 14 3 described describe VBN cord-011418-hy8xmtiq 14 4 in in IN cord-011418-hy8xmtiq 14 5 adults adult NNS cord-011418-hy8xmtiq 14 6 , , , cord-011418-hy8xmtiq 14 7 children child NNS cord-011418-hy8xmtiq 14 8 also also RB cord-011418-hy8xmtiq 14 9 suffer suffer VBP cord-011418-hy8xmtiq 14 10 from from IN cord-011418-hy8xmtiq 14 11 PICS pic NNS cord-011418-hy8xmtiq 14 12 . . . cord-011418-hy8xmtiq 15 1 The the DT cord-011418-hy8xmtiq 15 2 ICU ICU NNP cord-011418-hy8xmtiq 15 3 liberation liberation NN cord-011418-hy8xmtiq 15 4 bundle bundle NN cord-011418-hy8xmtiq 15 5 is be VBZ cord-011418-hy8xmtiq 15 6 feasible feasible JJ cord-011418-hy8xmtiq 15 7 in in IN cord-011418-hy8xmtiq 15 8 children child NNS cord-011418-hy8xmtiq 15 9 and and CC cord-011418-hy8xmtiq 15 10 may may MD cord-011418-hy8xmtiq 15 11 ameliorate ameliorate VB cord-011418-hy8xmtiq 15 12 the the DT cord-011418-hy8xmtiq 15 13 effects effect NNS cord-011418-hy8xmtiq 15 14 of of IN cord-011418-hy8xmtiq 15 15 a a DT cord-011418-hy8xmtiq 15 16 PICU PICU NNP cord-011418-hy8xmtiq 15 17 stay stay NN cord-011418-hy8xmtiq 15 18 . . . cord-011418-hy8xmtiq 16 1 Further further JJ cord-011418-hy8xmtiq 16 2 studies study NNS cord-011418-hy8xmtiq 16 3 are be VBP cord-011418-hy8xmtiq 16 4 needed need VBN cord-011418-hy8xmtiq 16 5 to to TO cord-011418-hy8xmtiq 16 6 characterize characterize VB cord-011418-hy8xmtiq 16 7 the the DT cord-011418-hy8xmtiq 16 8 benefits benefit NNS cord-011418-hy8xmtiq 16 9 of of IN cord-011418-hy8xmtiq 16 10 the the DT cord-011418-hy8xmtiq 16 11 ICU ICU NNP cord-011418-hy8xmtiq 16 12 liberation liberation NN cord-011418-hy8xmtiq 16 13 bundle bundle NN cord-011418-hy8xmtiq 16 14 in in IN cord-011418-hy8xmtiq 16 15 children child NNS cord-011418-hy8xmtiq 16 16 . . . cord-011418-hy8xmtiq 17 1 The the DT cord-011418-hy8xmtiq 17 2 landscape landscape NN cord-011418-hy8xmtiq 17 3 of of IN cord-011418-hy8xmtiq 17 4 pediatric pediatric JJ cord-011418-hy8xmtiq 17 5 intensive intensive JJ cord-011418-hy8xmtiq 17 6 care care NN cord-011418-hy8xmtiq 17 7 has have VBZ cord-011418-hy8xmtiq 17 8 changed change VBN cord-011418-hy8xmtiq 17 9 immensely immensely RB cord-011418-hy8xmtiq 17 10 since since IN cord-011418-hy8xmtiq 17 11 the the DT cord-011418-hy8xmtiq 17 12 advent advent NN cord-011418-hy8xmtiq 17 13 of of IN cord-011418-hy8xmtiq 17 14 the the DT cord-011418-hy8xmtiq 17 15 first first JJ cord-011418-hy8xmtiq 17 16 pediatric pediatric JJ cord-011418-hy8xmtiq 17 17 intensive intensive JJ cord-011418-hy8xmtiq 17 18 care care NN cord-011418-hy8xmtiq 17 19 units unit NNS cord-011418-hy8xmtiq 17 20 ( ( -LRB- cord-011418-hy8xmtiq 17 21 PICUs PICUs NNP cord-011418-hy8xmtiq 17 22 ) ) -RRB- cord-011418-hy8xmtiq 17 23 in in IN cord-011418-hy8xmtiq 17 24 the the DT cord-011418-hy8xmtiq 17 25 1950s 1950 NNS cord-011418-hy8xmtiq 17 26 and and CC cord-011418-hy8xmtiq 17 27 1960s 1960 NNS cord-011418-hy8xmtiq 17 28 [ [ -LRB- cord-011418-hy8xmtiq 17 29 1 1 CD cord-011418-hy8xmtiq 17 30 ] ] -RRB- cord-011418-hy8xmtiq 17 31 . . . cord-011418-hy8xmtiq 18 1 Through through IN cord-011418-hy8xmtiq 18 2 advances advance NNS cord-011418-hy8xmtiq 18 3 in in IN cord-011418-hy8xmtiq 18 4 mechanical mechanical JJ cord-011418-hy8xmtiq 18 5 support support NN cord-011418-hy8xmtiq 18 6 , , , cord-011418-hy8xmtiq 18 7 medications medication NNS cord-011418-hy8xmtiq 18 8 , , , cord-011418-hy8xmtiq 18 9 and and CC cord-011418-hy8xmtiq 18 10 procedures procedure NNS cord-011418-hy8xmtiq 18 11 , , , cord-011418-hy8xmtiq 18 12 mortality mortality NN cord-011418-hy8xmtiq 18 13 has have VBZ cord-011418-hy8xmtiq 18 14 been be VBN cord-011418-hy8xmtiq 18 15 greatly greatly RB cord-011418-hy8xmtiq 18 16 reduced reduce VBN cord-011418-hy8xmtiq 18 17 [ [ -LRB- cord-011418-hy8xmtiq 18 18 2 2 CD cord-011418-hy8xmtiq 18 19 ] ] -RRB- cord-011418-hy8xmtiq 18 20 , , , cord-011418-hy8xmtiq 18 21 but but CC cord-011418-hy8xmtiq 18 22 many many JJ cord-011418-hy8xmtiq 18 23 pediatric pediatric JJ cord-011418-hy8xmtiq 18 24 survivors survivor NNS cord-011418-hy8xmtiq 18 25 of of IN cord-011418-hy8xmtiq 18 26 critical critical JJ cord-011418-hy8xmtiq 18 27 illnesses illness NNS cord-011418-hy8xmtiq 18 28 will will MD cord-011418-hy8xmtiq 18 29 experience experience VB cord-011418-hy8xmtiq 18 30 long long JJ cord-011418-hy8xmtiq 18 31 - - HYPH cord-011418-hy8xmtiq 18 32 term term NN cord-011418-hy8xmtiq 18 33 disabilities disability NNS cord-011418-hy8xmtiq 18 34 , , , cord-011418-hy8xmtiq 18 35 higher high JJR cord-011418-hy8xmtiq 18 36 readmission readmission NN cord-011418-hy8xmtiq 18 37 rates rate NNS cord-011418-hy8xmtiq 18 38 , , , cord-011418-hy8xmtiq 18 39 and and CC cord-011418-hy8xmtiq 18 40 overall overall JJ cord-011418-hy8xmtiq 18 41 poorer poor JJR cord-011418-hy8xmtiq 18 42 health health NN cord-011418-hy8xmtiq 18 43 status status NN cord-011418-hy8xmtiq 18 44 [ [ -LRB- cord-011418-hy8xmtiq 18 45 3 3 CD cord-011418-hy8xmtiq 18 46 ] ] -RRB- cord-011418-hy8xmtiq 18 47 [ [ -LRB- cord-011418-hy8xmtiq 18 48 4 4 CD cord-011418-hy8xmtiq 18 49 ] ] -RRB- cord-011418-hy8xmtiq 18 50 [ [ -LRB- cord-011418-hy8xmtiq 18 51 5 5 CD cord-011418-hy8xmtiq 18 52 ] ] -RRB- cord-011418-hy8xmtiq 18 53 [ [ -LRB- cord-011418-hy8xmtiq 18 54 6 6 CD cord-011418-hy8xmtiq 18 55 ] ] -RRB- cord-011418-hy8xmtiq 18 56 [ [ -LRB- cord-011418-hy8xmtiq 18 57 7 7 CD cord-011418-hy8xmtiq 18 58 ] ] -RRB- cord-011418-hy8xmtiq 18 59 [ [ -LRB- cord-011418-hy8xmtiq 18 60 8 8 CD cord-011418-hy8xmtiq 18 61 ] ] -RRB- cord-011418-hy8xmtiq 18 62 . . . cord-011418-hy8xmtiq 19 1 Such such JJ cord-011418-hy8xmtiq 19 2 knowledge knowledge NN cord-011418-hy8xmtiq 19 3 of of IN cord-011418-hy8xmtiq 19 4 the the DT cord-011418-hy8xmtiq 19 5 harm harm NN cord-011418-hy8xmtiq 19 6 of of IN cord-011418-hy8xmtiq 19 7 an an DT cord-011418-hy8xmtiq 19 8 ICU ICU NNP cord-011418-hy8xmtiq 19 9 stay stay NN cord-011418-hy8xmtiq 19 10 , , , cord-011418-hy8xmtiq 19 11 initially initially RB cord-011418-hy8xmtiq 19 12 described describe VBN cord-011418-hy8xmtiq 19 13 in in IN cord-011418-hy8xmtiq 19 14 the the DT cord-011418-hy8xmtiq 19 15 adult adult NN cord-011418-hy8xmtiq 19 16 ICU ICU NNP cord-011418-hy8xmtiq 19 17 population population NN cord-011418-hy8xmtiq 19 18 , , , cord-011418-hy8xmtiq 19 19 led lead VBD cord-011418-hy8xmtiq 19 20 the the DT cord-011418-hy8xmtiq 19 21 movement movement NN cord-011418-hy8xmtiq 19 22 to to TO cord-011418-hy8xmtiq 19 23 reevaluate reevaluate VB cord-011418-hy8xmtiq 19 24 ICU ICU NNP cord-011418-hy8xmtiq 19 25 clinical clinical JJ cord-011418-hy8xmtiq 19 26 practice practice NN cord-011418-hy8xmtiq 19 27 patterns pattern NNS cord-011418-hy8xmtiq 19 28 and and CC cord-011418-hy8xmtiq 19 29 culture culture NN cord-011418-hy8xmtiq 19 30 . . . cord-011418-hy8xmtiq 20 1 With with IN cord-011418-hy8xmtiq 20 2 increasing increase VBG cord-011418-hy8xmtiq 20 3 awareness awareness NN cord-011418-hy8xmtiq 20 4 of of IN cord-011418-hy8xmtiq 20 5 the the DT cord-011418-hy8xmtiq 20 6 long long JJ cord-011418-hy8xmtiq 20 7 - - HYPH cord-011418-hy8xmtiq 20 8 term term NN cord-011418-hy8xmtiq 20 9 detriments detriment NNS cord-011418-hy8xmtiq 20 10 of of IN cord-011418-hy8xmtiq 20 11 an an DT cord-011418-hy8xmtiq 20 12 ICU ICU NNP cord-011418-hy8xmtiq 20 13 stay stay NN cord-011418-hy8xmtiq 20 14 , , , cord-011418-hy8xmtiq 20 15 the the DT cord-011418-hy8xmtiq 20 16 term term NN cord-011418-hy8xmtiq 20 17 post post JJ cord-011418-hy8xmtiq 20 18 - - JJ cord-011418-hy8xmtiq 20 19 intensive intensive JJ cord-011418-hy8xmtiq 20 20 care care NN cord-011418-hy8xmtiq 20 21 syndrome syndrome NN cord-011418-hy8xmtiq 20 22 ( ( -LRB- cord-011418-hy8xmtiq 20 23 PICS PICS NNP cord-011418-hy8xmtiq 20 24 ) ) -RRB- cord-011418-hy8xmtiq 20 25 was be VBD cord-011418-hy8xmtiq 20 26 coined coin VBN cord-011418-hy8xmtiq 20 27 to to TO cord-011418-hy8xmtiq 20 28 describe describe VB cord-011418-hy8xmtiq 20 29 the the DT cord-011418-hy8xmtiq 20 30 combination combination NN cord-011418-hy8xmtiq 20 31 of of IN cord-011418-hy8xmtiq 20 32 negative negative JJ cord-011418-hy8xmtiq 20 33 cognitive cognitive JJ cord-011418-hy8xmtiq 20 34 , , , cord-011418-hy8xmtiq 20 35 psychological psychological JJ cord-011418-hy8xmtiq 20 36 , , , cord-011418-hy8xmtiq 20 37 and and CC cord-011418-hy8xmtiq 20 38 physical physical JJ cord-011418-hy8xmtiq 20 39 effects effect NNS cord-011418-hy8xmtiq 20 40 after after IN cord-011418-hy8xmtiq 20 41 critical critical JJ cord-011418-hy8xmtiq 20 42 illness illness NN cord-011418-hy8xmtiq 20 43 [ [ -LRB- cord-011418-hy8xmtiq 20 44 9 9 CD cord-011418-hy8xmtiq 20 45 , , , cord-011418-hy8xmtiq 20 46 10• 10• CD cord-011418-hy8xmtiq 20 47 ] ] -RRB- cord-011418-hy8xmtiq 20 48 . . . cord-011418-hy8xmtiq 21 1 PICS pic NNS cord-011418-hy8xmtiq 21 2 has have VBZ cord-011418-hy8xmtiq 21 3 been be VBN cord-011418-hy8xmtiq 21 4 described describe VBN cord-011418-hy8xmtiq 21 5 in in IN cord-011418-hy8xmtiq 21 6 children child NNS cord-011418-hy8xmtiq 21 7 as as RB cord-011418-hy8xmtiq 21 8 well well RB cord-011418-hy8xmtiq 21 9 , , , cord-011418-hy8xmtiq 21 10 although although IN cord-011418-hy8xmtiq 21 11 the the DT cord-011418-hy8xmtiq 21 12 true true JJ cord-011418-hy8xmtiq 21 13 incidence incidence NN cord-011418-hy8xmtiq 21 14 is be VBZ cord-011418-hy8xmtiq 21 15 difficult difficult JJ cord-011418-hy8xmtiq 21 16 to to TO cord-011418-hy8xmtiq 21 17 determine determine VB cord-011418-hy8xmtiq 21 18 [ [ -LRB- cord-011418-hy8xmtiq 21 19 11 11 CD cord-011418-hy8xmtiq 21 20 , , , cord-011418-hy8xmtiq 21 21 12 12 CD cord-011418-hy8xmtiq 21 22 ] ] -RRB- cord-011418-hy8xmtiq 21 23 . . . cord-011418-hy8xmtiq 22 1 Studies study NNS cord-011418-hy8xmtiq 22 2 have have VBP cord-011418-hy8xmtiq 22 3 shown show VBN cord-011418-hy8xmtiq 22 4 up up RP cord-011418-hy8xmtiq 22 5 to to TO cord-011418-hy8xmtiq 22 6 25 25 CD cord-011418-hy8xmtiq 22 7 % % NN cord-011418-hy8xmtiq 22 8 of of IN cord-011418-hy8xmtiq 22 9 children child NNS cord-011418-hy8xmtiq 22 10 may may MD cord-011418-hy8xmtiq 22 11 display display VB cord-011418-hy8xmtiq 22 12 negative negative JJ cord-011418-hy8xmtiq 22 13 psychological psychological JJ cord-011418-hy8xmtiq 22 14 and and CC cord-011418-hy8xmtiq 22 15 behavioral behavioral JJ cord-011418-hy8xmtiq 22 16 outcomes outcome NNS cord-011418-hy8xmtiq 22 17 in in IN cord-011418-hy8xmtiq 22 18 the the DT cord-011418-hy8xmtiq 22 19 first first JJ cord-011418-hy8xmtiq 22 20 year year NN cord-011418-hy8xmtiq 22 21 following follow VBG cord-011418-hy8xmtiq 22 22 PICU PICU NNP cord-011418-hy8xmtiq 22 23 discharge discharge NN cord-011418-hy8xmtiq 22 24 including include VBG cord-011418-hy8xmtiq 22 25 ongoing ongoing JJ cord-011418-hy8xmtiq 22 26 fears fear NNS cord-011418-hy8xmtiq 22 27 , , , cord-011418-hy8xmtiq 22 28 changes change NNS cord-011418-hy8xmtiq 22 29 in in IN cord-011418-hy8xmtiq 22 30 memory memory NN cord-011418-hy8xmtiq 22 31 , , , cord-011418-hy8xmtiq 22 32 attention attention NN cord-011418-hy8xmtiq 22 33 span span NN cord-011418-hy8xmtiq 22 34 , , , cord-011418-hy8xmtiq 22 35 cognitive cognitive JJ cord-011418-hy8xmtiq 22 36 functioning functioning NN cord-011418-hy8xmtiq 22 37 , , , cord-011418-hy8xmtiq 22 38 self self NN cord-011418-hy8xmtiq 22 39 - - HYPH cord-011418-hy8xmtiq 22 40 esteem esteem NN cord-011418-hy8xmtiq 22 41 , , , cord-011418-hy8xmtiq 22 42 or or CC cord-011418-hy8xmtiq 22 43 self self NN cord-011418-hy8xmtiq 22 44 - - HYPH cord-011418-hy8xmtiq 22 45 confidence confidence NN cord-011418-hy8xmtiq 22 46 , , , cord-011418-hy8xmtiq 22 47 and and CC cord-011418-hy8xmtiq 22 48 a a DT cord-011418-hy8xmtiq 22 49 large large JJ cord-011418-hy8xmtiq 22 50 proportion proportion NN cord-011418-hy8xmtiq 22 51 of of IN cord-011418-hy8xmtiq 22 52 PICU PICU NNP cord-011418-hy8xmtiq 22 53 survivors survivor NNS cord-011418-hy8xmtiq 22 54 may may MD cord-011418-hy8xmtiq 22 55 suffer suffer VB cord-011418-hy8xmtiq 22 56 from from IN cord-011418-hy8xmtiq 22 57 posttraumatic posttraumatic JJ cord-011418-hy8xmtiq 22 58 stress stress NN cord-011418-hy8xmtiq 22 59 symptoms symptom NNS cord-011418-hy8xmtiq 22 60 [ [ -LRB- cord-011418-hy8xmtiq 22 61 13 13 CD cord-011418-hy8xmtiq 22 62 ] ] -RRB- cord-011418-hy8xmtiq 23 1 [ [ -LRB- cord-011418-hy8xmtiq 23 2 14 14 CD cord-011418-hy8xmtiq 23 3 ] ] -RRB- cord-011418-hy8xmtiq 23 4 [ [ -LRB- cord-011418-hy8xmtiq 23 5 15 15 CD cord-011418-hy8xmtiq 23 6 ] ] -RRB- cord-011418-hy8xmtiq 23 7 . . . cord-011418-hy8xmtiq 24 1 Several several JJ cord-011418-hy8xmtiq 24 2 studies study NNS cord-011418-hy8xmtiq 24 3 have have VBP cord-011418-hy8xmtiq 24 4 described describe VBN cord-011418-hy8xmtiq 24 5 significant significant JJ cord-011418-hy8xmtiq 24 6 motor motor NN cord-011418-hy8xmtiq 24 7 deficits deficit NNS cord-011418-hy8xmtiq 24 8 and and CC cord-011418-hy8xmtiq 24 9 exacerbation exacerbation NN cord-011418-hy8xmtiq 24 10 of of IN cord-011418-hy8xmtiq 24 11 baseline baseline JJ cord-011418-hy8xmtiq 24 12 physical physical JJ cord-011418-hy8xmtiq 24 13 disabilities disability NNS cord-011418-hy8xmtiq 24 14 in in IN cord-011418-hy8xmtiq 24 15 children child NNS cord-011418-hy8xmtiq 24 16 post post VBP cord-011418-hy8xmtiq 24 17 - - JJ cord-011418-hy8xmtiq 24 18 ICU ICU NNP cord-011418-hy8xmtiq 24 19 stay stay VB cord-011418-hy8xmtiq 24 20 [ [ -LRB- cord-011418-hy8xmtiq 24 21 4 4 CD cord-011418-hy8xmtiq 24 22 , , , cord-011418-hy8xmtiq 24 23 6 6 CD cord-011418-hy8xmtiq 24 24 , , , cord-011418-hy8xmtiq 24 25 16 16 CD cord-011418-hy8xmtiq 24 26 ] ] -RRB- cord-011418-hy8xmtiq 24 27 . . . cord-011418-hy8xmtiq 25 1 A a DT cord-011418-hy8xmtiq 25 2 systematic systematic JJ cord-011418-hy8xmtiq 25 3 review review NN cord-011418-hy8xmtiq 25 4 published publish VBN cord-011418-hy8xmtiq 25 5 in in IN cord-011418-hy8xmtiq 25 6 2017 2017 CD cord-011418-hy8xmtiq 25 7 found find VBD cord-011418-hy8xmtiq 25 8 19 19 CD cord-011418-hy8xmtiq 25 9 studies study NNS cord-011418-hy8xmtiq 25 10 documenting document VBG cord-011418-hy8xmtiq 25 11 deficits deficit NNS cord-011418-hy8xmtiq 25 12 in in IN cord-011418-hy8xmtiq 25 13 all all DT cord-011418-hy8xmtiq 25 14 three three CD cord-011418-hy8xmtiq 25 15 PICS PICS NNPS cord-011418-hy8xmtiq 25 16 domains domain NNS cord-011418-hy8xmtiq 25 17 in in IN cord-011418-hy8xmtiq 25 18 PICU PICU NNP cord-011418-hy8xmtiq 25 19 survivors survivor NNS cord-011418-hy8xmtiq 25 20 [ [ -LRB- cord-011418-hy8xmtiq 25 21 12 12 CD cord-011418-hy8xmtiq 25 22 ] ] -RRB- cord-011418-hy8xmtiq 25 23 . . . cord-011418-hy8xmtiq 26 1 Although although IN cord-011418-hy8xmtiq 26 2 these these DT cord-011418-hy8xmtiq 26 3 pediatric pediatric JJ cord-011418-hy8xmtiq 26 4 cohort cohort NN cord-011418-hy8xmtiq 26 5 studies study NNS cord-011418-hy8xmtiq 26 6 have have VBP cord-011418-hy8xmtiq 26 7 found find VBN cord-011418-hy8xmtiq 26 8 significant significant JJ cord-011418-hy8xmtiq 26 9 morbidities morbidity NNS cord-011418-hy8xmtiq 26 10 , , , cord-011418-hy8xmtiq 26 11 it -PRON- PRP cord-011418-hy8xmtiq 26 12 is be VBZ cord-011418-hy8xmtiq 26 13 difficult difficult JJ cord-011418-hy8xmtiq 26 14 to to TO cord-011418-hy8xmtiq 26 15 compare compare VB cord-011418-hy8xmtiq 26 16 data datum NNS cord-011418-hy8xmtiq 26 17 and and CC cord-011418-hy8xmtiq 26 18 estimate estimate VB cord-011418-hy8xmtiq 26 19 a a DT cord-011418-hy8xmtiq 26 20 true true JJ cord-011418-hy8xmtiq 26 21 incidence incidence NN cord-011418-hy8xmtiq 26 22 due due IN cord-011418-hy8xmtiq 26 23 to to IN cord-011418-hy8xmtiq 26 24 varied varied JJ cord-011418-hy8xmtiq 26 25 outcomes outcome NNS cord-011418-hy8xmtiq 26 26 scales scale NNS cord-011418-hy8xmtiq 26 27 and and CC cord-011418-hy8xmtiq 26 28 measures measure NNS cord-011418-hy8xmtiq 26 29 [ [ -LRB- cord-011418-hy8xmtiq 26 30 12 12 CD cord-011418-hy8xmtiq 26 31 ] ] -RRB- cord-011418-hy8xmtiq 26 32 . . . cord-011418-hy8xmtiq 27 1 In in IN cord-011418-hy8xmtiq 27 2 addition addition NN cord-011418-hy8xmtiq 27 3 to to IN cord-011418-hy8xmtiq 27 4 patient patient JJ cord-011418-hy8xmtiq 27 5 deficits deficit NNS cord-011418-hy8xmtiq 27 6 , , , cord-011418-hy8xmtiq 27 7 parents parent NNS cord-011418-hy8xmtiq 27 8 or or CC cord-011418-hy8xmtiq 27 9 family family NN cord-011418-hy8xmtiq 27 10 members member NNS cord-011418-hy8xmtiq 27 11 of of IN cord-011418-hy8xmtiq 27 12 critically critically RB cord-011418-hy8xmtiq 27 13 ill ill JJ cord-011418-hy8xmtiq 27 14 children child NNS cord-011418-hy8xmtiq 27 15 can can MD cord-011418-hy8xmtiq 27 16 experience experience VB cord-011418-hy8xmtiq 27 17 depression depression NN cord-011418-hy8xmtiq 27 18 or or CC cord-011418-hy8xmtiq 27 19 post post JJ cord-011418-hy8xmtiq 27 20 - - JJ cord-011418-hy8xmtiq 27 21 traumatic traumatic JJ cord-011418-hy8xmtiq 27 22 stress stress NN cord-011418-hy8xmtiq 27 23 disorder disorder NN cord-011418-hy8xmtiq 27 24 ( ( -LRB- cord-011418-hy8xmtiq 27 25 PTSD PTSD NNP cord-011418-hy8xmtiq 27 26 ) ) -RRB- cord-011418-hy8xmtiq 27 27 symptoms symptom NNS cord-011418-hy8xmtiq 27 28 as as RB cord-011418-hy8xmtiq 27 29 well well RB cord-011418-hy8xmtiq 27 30 [ [ -LRB- cord-011418-hy8xmtiq 27 31 13 13 CD cord-011418-hy8xmtiq 27 32 , , , cord-011418-hy8xmtiq 27 33 17 17 CD cord-011418-hy8xmtiq 27 34 ] ] -RRB- cord-011418-hy8xmtiq 27 35 . . . cord-011418-hy8xmtiq 28 1 Given give VBN cord-011418-hy8xmtiq 28 2 these these DT cord-011418-hy8xmtiq 28 3 findings finding NNS cord-011418-hy8xmtiq 28 4 , , , cord-011418-hy8xmtiq 28 5 recent recent JJ cord-011418-hy8xmtiq 28 6 focus focus NN cord-011418-hy8xmtiq 28 7 has have VBZ cord-011418-hy8xmtiq 28 8 shifted shift VBN cord-011418-hy8xmtiq 28 9 from from IN cord-011418-hy8xmtiq 28 10 solely solely RB cord-011418-hy8xmtiq 28 11 improving improve VBG cord-011418-hy8xmtiq 28 12 mortality mortality NN cord-011418-hy8xmtiq 28 13 to to IN cord-011418-hy8xmtiq 28 14 better well JJR cord-011418-hy8xmtiq 28 15 understanding understanding NN cord-011418-hy8xmtiq 28 16 and and CC cord-011418-hy8xmtiq 28 17 preventing prevent VBG cord-011418-hy8xmtiq 28 18 the the DT cord-011418-hy8xmtiq 28 19 long long JJ cord-011418-hy8xmtiq 28 20 - - HYPH cord-011418-hy8xmtiq 28 21 term term NN cord-011418-hy8xmtiq 28 22 psychologic psychologic JJ cord-011418-hy8xmtiq 28 23 , , , cord-011418-hy8xmtiq 28 24 social social JJ cord-011418-hy8xmtiq 28 25 , , , cord-011418-hy8xmtiq 28 26 and and CC cord-011418-hy8xmtiq 28 27 physical physical JJ cord-011418-hy8xmtiq 28 28 impairment impairment NN cord-011418-hy8xmtiq 28 29 experienced experience VBN cord-011418-hy8xmtiq 28 30 by by IN cord-011418-hy8xmtiq 28 31 critically critically RB cord-011418-hy8xmtiq 28 32 ill ill JJ cord-011418-hy8xmtiq 28 33 patients patient NNS cord-011418-hy8xmtiq 28 34 and and CC cord-011418-hy8xmtiq 28 35 their -PRON- PRP$ cord-011418-hy8xmtiq 28 36 families family NNS cord-011418-hy8xmtiq 28 37 . . . cord-011418-hy8xmtiq 29 1 A a DT cord-011418-hy8xmtiq 29 2 compelling compelling JJ cord-011418-hy8xmtiq 29 3 body body NN cord-011418-hy8xmtiq 29 4 of of IN cord-011418-hy8xmtiq 29 5 literature literature NN cord-011418-hy8xmtiq 29 6 , , , cord-011418-hy8xmtiq 29 7 mostly mostly RB cord-011418-hy8xmtiq 29 8 adult adult NN cord-011418-hy8xmtiq 29 9 , , , cord-011418-hy8xmtiq 29 10 surfaced surface VBD cord-011418-hy8xmtiq 29 11 to to TO cord-011418-hy8xmtiq 29 12 support support VB cord-011418-hy8xmtiq 29 13 several several JJ cord-011418-hy8xmtiq 29 14 changes change NNS cord-011418-hy8xmtiq 29 15 in in IN cord-011418-hy8xmtiq 29 16 clinical clinical JJ cord-011418-hy8xmtiq 29 17 care care NN cord-011418-hy8xmtiq 29 18 to to TO cord-011418-hy8xmtiq 29 19 ameliorate ameliorate VB cord-011418-hy8xmtiq 29 20 PICS pic NNS cord-011418-hy8xmtiq 29 21 and and CC cord-011418-hy8xmtiq 29 22 the the DT cord-011418-hy8xmtiq 29 23 effects effect NNS cord-011418-hy8xmtiq 29 24 of of IN cord-011418-hy8xmtiq 29 25 an an DT cord-011418-hy8xmtiq 29 26 ICU ICU NNP cord-011418-hy8xmtiq 29 27 stay stay NN cord-011418-hy8xmtiq 29 28 . . . cord-011418-hy8xmtiq 30 1 The the DT cord-011418-hy8xmtiq 30 2 ICU ICU NNP cord-011418-hy8xmtiq 30 3 Liberation Liberation NNP cord-011418-hy8xmtiq 30 4 Collaborative Collaborative NNP cord-011418-hy8xmtiq 30 5 was be VBD cord-011418-hy8xmtiq 30 6 a a DT cord-011418-hy8xmtiq 30 7 quality quality NN cord-011418-hy8xmtiq 30 8 improvement improvement NN cord-011418-hy8xmtiq 30 9 initiative initiative NN cord-011418-hy8xmtiq 30 10 hosted host VBN cord-011418-hy8xmtiq 30 11 by by IN cord-011418-hy8xmtiq 30 12 the the DT cord-011418-hy8xmtiq 30 13 Society Society NNP cord-011418-hy8xmtiq 30 14 of of IN cord-011418-hy8xmtiq 30 15 Critical Critical NNP cord-011418-hy8xmtiq 30 16 Care Care NNP cord-011418-hy8xmtiq 30 17 Medicine Medicine NNP cord-011418-hy8xmtiq 30 18 among among IN cord-011418-hy8xmtiq 30 19 76 76 CD cord-011418-hy8xmtiq 30 20 hospitals hospital NNS cord-011418-hy8xmtiq 30 21 ( ( -LRB- cord-011418-hy8xmtiq 30 22 67 67 CD cord-011418-hy8xmtiq 30 23 adult adult NN cord-011418-hy8xmtiq 30 24 and and CC cord-011418-hy8xmtiq 30 25 9 9 CD cord-011418-hy8xmtiq 30 26 pediatric pediatric NN cord-011418-hy8xmtiq 30 27 ) ) -RRB- cord-011418-hy8xmtiq 30 28 formed form VBD cord-011418-hy8xmtiq 30 29 to to TO cord-011418-hy8xmtiq 30 30 implement implement VB cord-011418-hy8xmtiq 30 31 and and CC cord-011418-hy8xmtiq 30 32 assess assess VB cord-011418-hy8xmtiq 30 33 changes change NNS cord-011418-hy8xmtiq 30 34 in in IN cord-011418-hy8xmtiq 30 35 clinical clinical JJ cord-011418-hy8xmtiq 30 36 practice practice NN cord-011418-hy8xmtiq 30 37 aimed aim VBN cord-011418-hy8xmtiq 30 38 at at IN cord-011418-hy8xmtiq 30 39 improving improve VBG cord-011418-hy8xmtiq 30 40 patient patient JJ cord-011418-hy8xmtiq 30 41 outcomes outcome NNS cord-011418-hy8xmtiq 30 42 . . . cord-011418-hy8xmtiq 31 1 The the DT cord-011418-hy8xmtiq 31 2 collaborative collaborative NN cord-011418-hy8xmtiq 31 3 worked work VBD cord-011418-hy8xmtiq 31 4 to to TO cord-011418-hy8xmtiq 31 5 integrate integrate VB cord-011418-hy8xmtiq 31 6 the the DT cord-011418-hy8xmtiq 31 7 ICU ICU NNP cord-011418-hy8xmtiq 31 8 liberation liberation NN cord-011418-hy8xmtiq 31 9 bundle bundle NN cord-011418-hy8xmtiq 31 10 , , , cord-011418-hy8xmtiq 31 11 also also RB cord-011418-hy8xmtiq 31 12 known know VBN cord-011418-hy8xmtiq 31 13 as as IN cord-011418-hy8xmtiq 31 14 the the DT cord-011418-hy8xmtiq 31 15 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 31 16 bundle bundle NN cord-011418-hy8xmtiq 31 17 , , , cord-011418-hy8xmtiq 31 18 in in IN cord-011418-hy8xmtiq 31 19 the the DT cord-011418-hy8xmtiq 31 20 care care NN cord-011418-hy8xmtiq 31 21 of of IN cord-011418-hy8xmtiq 31 22 their -PRON- PRP$ cord-011418-hy8xmtiq 31 23 patients patient NNS cord-011418-hy8xmtiq 31 24 to to TO cord-011418-hy8xmtiq 31 25 mitigate mitigate VB cord-011418-hy8xmtiq 31 26 the the DT cord-011418-hy8xmtiq 31 27 effects effect NNS cord-011418-hy8xmtiq 31 28 of of IN cord-011418-hy8xmtiq 31 29 an an DT cord-011418-hy8xmtiq 31 30 ICU ICU NNP cord-011418-hy8xmtiq 31 31 stay stay NN cord-011418-hy8xmtiq 31 32 [ [ -LRB- cord-011418-hy8xmtiq 31 33 10• 10• CD cord-011418-hy8xmtiq 31 34 ] ] -RRB- cord-011418-hy8xmtiq 31 35 . . . cord-011418-hy8xmtiq 32 1 Bundle bundle NN cord-011418-hy8xmtiq 32 2 implementation implementation NN cord-011418-hy8xmtiq 32 3 resulted result VBD cord-011418-hy8xmtiq 32 4 in in IN cord-011418-hy8xmtiq 32 5 substantial substantial JJ cord-011418-hy8xmtiq 32 6 improvements improvement NNS cord-011418-hy8xmtiq 32 7 among among IN cord-011418-hy8xmtiq 32 8 adult adult NN cord-011418-hy8xmtiq 32 9 ICU ICU NNP cord-011418-hy8xmtiq 32 10 patients patient NNS cord-011418-hy8xmtiq 32 11 [ [ -LRB- cord-011418-hy8xmtiq 32 12 18•• 18•• CD cord-011418-hy8xmtiq 32 13 , , , cord-011418-hy8xmtiq 32 14 19 19 CD cord-011418-hy8xmtiq 32 15 ] ] -RRB- cord-011418-hy8xmtiq 32 16 . . . cord-011418-hy8xmtiq 33 1 In in IN cord-011418-hy8xmtiq 33 2 two two CD cord-011418-hy8xmtiq 33 3 large large JJ cord-011418-hy8xmtiq 33 4 multicenter multicenter JJ cord-011418-hy8xmtiq 33 5 studies study NNS cord-011418-hy8xmtiq 33 6 at at IN cord-011418-hy8xmtiq 33 7 varied varied JJ cord-011418-hy8xmtiq 33 8 types type NNS cord-011418-hy8xmtiq 33 9 of of IN cord-011418-hy8xmtiq 33 10 ICUs ICUs NNP cord-011418-hy8xmtiq 33 11 [ [ -LRB- cord-011418-hy8xmtiq 33 12 18•• 18•• CD cord-011418-hy8xmtiq 33 13 , , , cord-011418-hy8xmtiq 33 14 19 19 CD cord-011418-hy8xmtiq 33 15 ] ] -RRB- cord-011418-hy8xmtiq 33 16 , , , cord-011418-hy8xmtiq 33 17 even even RB cord-011418-hy8xmtiq 33 18 partial partial JJ cord-011418-hy8xmtiq 33 19 bundle bundle NN cord-011418-hy8xmtiq 33 20 implementation implementation NN cord-011418-hy8xmtiq 33 21 resulted result VBD cord-011418-hy8xmtiq 33 22 in in IN cord-011418-hy8xmtiq 33 23 improvement improvement NN cord-011418-hy8xmtiq 33 24 in in IN cord-011418-hy8xmtiq 33 25 survival survival NN cord-011418-hy8xmtiq 33 26 , , , cord-011418-hy8xmtiq 33 27 mechanical mechanical JJ cord-011418-hy8xmtiq 33 28 ventilation ventilation NN cord-011418-hy8xmtiq 33 29 use use NN cord-011418-hy8xmtiq 33 30 , , , cord-011418-hy8xmtiq 33 31 coma coma NN cord-011418-hy8xmtiq 33 32 , , , cord-011418-hy8xmtiq 33 33 delirium delirium NN cord-011418-hy8xmtiq 33 34 , , , cord-011418-hy8xmtiq 33 35 restraint restraint NN cord-011418-hy8xmtiq 33 36 - - HYPH cord-011418-hy8xmtiq 33 37 free free JJ cord-011418-hy8xmtiq 33 38 care care NN cord-011418-hy8xmtiq 33 39 , , , cord-011418-hy8xmtiq 33 40 ICU ICU NNP cord-011418-hy8xmtiq 33 41 readmissions readmission NNS cord-011418-hy8xmtiq 33 42 , , , cord-011418-hy8xmtiq 33 43 and and CC cord-011418-hy8xmtiq 33 44 post post JJ cord-011418-hy8xmtiq 33 45 - - JJ cord-011418-hy8xmtiq 33 46 ICU icu JJ cord-011418-hy8xmtiq 33 47 discharge discharge NN cord-011418-hy8xmtiq 33 48 disposition disposition NN cord-011418-hy8xmtiq 33 49 . . . cord-011418-hy8xmtiq 34 1 Furthermore furthermore RB cord-011418-hy8xmtiq 34 2 , , , cord-011418-hy8xmtiq 34 3 the the DT cord-011418-hy8xmtiq 34 4 data datum NNS cord-011418-hy8xmtiq 34 5 supported support VBD cord-011418-hy8xmtiq 34 6 a a DT cord-011418-hy8xmtiq 34 7 dose dose JJ cord-011418-hy8xmtiq 34 8 - - HYPH cord-011418-hy8xmtiq 34 9 response response NN cord-011418-hy8xmtiq 34 10 relationship relationship NN cord-011418-hy8xmtiq 34 11 , , , cord-011418-hy8xmtiq 34 12 in in IN cord-011418-hy8xmtiq 34 13 which which WDT cord-011418-hy8xmtiq 34 14 a a DT cord-011418-hy8xmtiq 34 15 higher high JJR cord-011418-hy8xmtiq 34 16 proportion proportion NN cord-011418-hy8xmtiq 34 17 of of IN cord-011418-hy8xmtiq 34 18 bundle bundle NN cord-011418-hy8xmtiq 34 19 compliance compliance NN cord-011418-hy8xmtiq 34 20 correlated correlate VBN cord-011418-hy8xmtiq 34 21 with with IN cord-011418-hy8xmtiq 34 22 improved improve VBN cord-011418-hy8xmtiq 34 23 clinical clinical JJ cord-011418-hy8xmtiq 34 24 outcomes outcome NNS cord-011418-hy8xmtiq 34 25 . . . cord-011418-hy8xmtiq 35 1 Although although IN cord-011418-hy8xmtiq 35 2 pediatric pediatric JJ cord-011418-hy8xmtiq 35 3 data datum NNS cord-011418-hy8xmtiq 35 4 is be VBZ cord-011418-hy8xmtiq 35 5 limited limit VBN cord-011418-hy8xmtiq 35 6 , , , cord-011418-hy8xmtiq 35 7 these these DT cord-011418-hy8xmtiq 35 8 results result NNS cord-011418-hy8xmtiq 35 9 have have VBP cord-011418-hy8xmtiq 35 10 further further RB cord-011418-hy8xmtiq 35 11 supported support VBN cord-011418-hy8xmtiq 35 12 the the DT cord-011418-hy8xmtiq 35 13 use use NN cord-011418-hy8xmtiq 35 14 of of IN cord-011418-hy8xmtiq 35 15 the the DT cord-011418-hy8xmtiq 35 16 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 35 17 bundle bundle NN cord-011418-hy8xmtiq 35 18 in in IN cord-011418-hy8xmtiq 35 19 all all DT cord-011418-hy8xmtiq 35 20 ICU ICU NNP cord-011418-hy8xmtiq 35 21 patients patient NNS cord-011418-hy8xmtiq 35 22 , , , cord-011418-hy8xmtiq 35 23 including include VBG cord-011418-hy8xmtiq 35 24 PICU PICU NNP cord-011418-hy8xmtiq 35 25 patients patient NNS cord-011418-hy8xmtiq 35 26 . . . cord-011418-hy8xmtiq 36 1 The the DT cord-011418-hy8xmtiq 36 2 ICU ICU NNP cord-011418-hy8xmtiq 36 3 liberation liberation NN cord-011418-hy8xmtiq 36 4 bundle bundle NN cord-011418-hy8xmtiq 36 5 , , , cord-011418-hy8xmtiq 36 6 also also RB cord-011418-hy8xmtiq 36 7 known know VBN cord-011418-hy8xmtiq 36 8 as as IN cord-011418-hy8xmtiq 36 9 the the DT cord-011418-hy8xmtiq 36 10 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 36 11 bundle bundle NN cord-011418-hy8xmtiq 36 12 ( ( -LRB- cord-011418-hy8xmtiq 36 13 Table Table NNP cord-011418-hy8xmtiq 36 14 1 1 CD cord-011418-hy8xmtiq 36 15 ) ) -RRB- cord-011418-hy8xmtiq 36 16 , , , cord-011418-hy8xmtiq 36 17 is be VBZ cord-011418-hy8xmtiq 36 18 an an DT cord-011418-hy8xmtiq 36 19 evidence evidence NN cord-011418-hy8xmtiq 36 20 - - HYPH cord-011418-hy8xmtiq 36 21 based base VBN cord-011418-hy8xmtiq 36 22 guideline guideline NN cord-011418-hy8xmtiq 36 23 to to TO cord-011418-hy8xmtiq 36 24 liberate liberate VB cord-011418-hy8xmtiq 36 25 patients patient NNS cord-011418-hy8xmtiq 36 26 from from IN cord-011418-hy8xmtiq 36 27 the the DT cord-011418-hy8xmtiq 36 28 harmful harmful JJ cord-011418-hy8xmtiq 36 29 effects effect NNS cord-011418-hy8xmtiq 36 30 of of IN cord-011418-hy8xmtiq 36 31 an an DT cord-011418-hy8xmtiq 36 32 ICU ICU NNP cord-011418-hy8xmtiq 36 33 stay stay NN cord-011418-hy8xmtiq 36 34 . . . cord-011418-hy8xmtiq 37 1 This this DT cord-011418-hy8xmtiq 37 2 large large JJ cord-011418-hy8xmtiq 37 3 - - HYPH cord-011418-hy8xmtiq 37 4 scale scale NN cord-011418-hy8xmtiq 37 5 quality quality NN cord-011418-hy8xmtiq 37 6 improvement improvement NN cord-011418-hy8xmtiq 37 7 strategy strategy NN cord-011418-hy8xmtiq 37 8 offers offer VBZ cord-011418-hy8xmtiq 37 9 guidance guidance NN cord-011418-hy8xmtiq 37 10 for for IN cord-011418-hy8xmtiq 37 11 the the DT cord-011418-hy8xmtiq 37 12 daily daily JJ cord-011418-hy8xmtiq 37 13 care care NN cord-011418-hy8xmtiq 37 14 of of IN cord-011418-hy8xmtiq 37 15 critically critically RB cord-011418-hy8xmtiq 37 16 ill ill JJ cord-011418-hy8xmtiq 37 17 patients patient NNS cord-011418-hy8xmtiq 37 18 that that WDT cord-011418-hy8xmtiq 37 19 can can MD cord-011418-hy8xmtiq 37 20 reduce reduce VB cord-011418-hy8xmtiq 37 21 pain pain NN cord-011418-hy8xmtiq 37 22 , , , cord-011418-hy8xmtiq 37 23 agitation agitation NN cord-011418-hy8xmtiq 37 24 , , , cord-011418-hy8xmtiq 37 25 and and CC cord-011418-hy8xmtiq 37 26 delirium delirium NN cord-011418-hy8xmtiq 37 27 , , , cord-011418-hy8xmtiq 37 28 in in IN cord-011418-hy8xmtiq 37 29 an an DT cord-011418-hy8xmtiq 37 30 effort effort NN cord-011418-hy8xmtiq 37 31 to to TO cord-011418-hy8xmtiq 37 32 prevent prevent VB cord-011418-hy8xmtiq 37 33 physical physical JJ cord-011418-hy8xmtiq 37 34 , , , cord-011418-hy8xmtiq 37 35 psychological psychological JJ cord-011418-hy8xmtiq 37 36 , , , cord-011418-hy8xmtiq 37 37 and and CC cord-011418-hy8xmtiq 37 38 cognitive cognitive JJ cord-011418-hy8xmtiq 37 39 morbidities morbidity NNS cord-011418-hy8xmtiq 37 40 that that WDT cord-011418-hy8xmtiq 37 41 limit limit VBP cord-011418-hy8xmtiq 37 42 or or CC cord-011418-hy8xmtiq 37 43 prolong prolong VB cord-011418-hy8xmtiq 37 44 recovery recovery NN cord-011418-hy8xmtiq 37 45 . . . cord-011418-hy8xmtiq 38 1 The the DT cord-011418-hy8xmtiq 38 2 components component NNS cord-011418-hy8xmtiq 38 3 of of IN cord-011418-hy8xmtiq 38 4 the the DT cord-011418-hy8xmtiq 38 5 bundle bundle NN cord-011418-hy8xmtiq 38 6 include include VBP cord-011418-hy8xmtiq 38 7 assessment assessment NN cord-011418-hy8xmtiq 38 8 , , , cord-011418-hy8xmtiq 38 9 prevention prevention NN cord-011418-hy8xmtiq 38 10 , , , cord-011418-hy8xmtiq 38 11 and and CC cord-011418-hy8xmtiq 38 12 management management NN cord-011418-hy8xmtiq 38 13 of of IN cord-011418-hy8xmtiq 38 14 pain pain NN cord-011418-hy8xmtiq 38 15 ; ; : cord-011418-hy8xmtiq 38 16 both both CC cord-011418-hy8xmtiq 38 17 spontaneous spontaneous JJ cord-011418-hy8xmtiq 38 18 awakening awakening NN cord-011418-hy8xmtiq 38 19 and and CC cord-011418-hy8xmtiq 38 20 breathing breathing NN cord-011418-hy8xmtiq 38 21 trials trial NNS cord-011418-hy8xmtiq 38 22 ; ; : cord-011418-hy8xmtiq 38 23 choice choice NN cord-011418-hy8xmtiq 38 24 of of IN cord-011418-hy8xmtiq 38 25 sedation sedation NN cord-011418-hy8xmtiq 38 26 and and CC cord-011418-hy8xmtiq 38 27 analgesia analgesia NN cord-011418-hy8xmtiq 38 28 ; ; : cord-011418-hy8xmtiq 38 29 delirium delirium NN cord-011418-hy8xmtiq 38 30 assessment assessment NN cord-011418-hy8xmtiq 38 31 , , , cord-011418-hy8xmtiq 38 32 prevention prevention NN cord-011418-hy8xmtiq 38 33 and and CC cord-011418-hy8xmtiq 38 34 management management NN cord-011418-hy8xmtiq 38 35 ; ; : cord-011418-hy8xmtiq 38 36 early early JJ cord-011418-hy8xmtiq 38 37 mobility mobility NN cord-011418-hy8xmtiq 38 38 and and CC cord-011418-hy8xmtiq 38 39 exercise exercise NN cord-011418-hy8xmtiq 38 40 ; ; : cord-011418-hy8xmtiq 38 41 and and CC cord-011418-hy8xmtiq 38 42 family family NN cord-011418-hy8xmtiq 38 43 engagement engagement NN cord-011418-hy8xmtiq 38 44 and and CC cord-011418-hy8xmtiq 38 45 empowerment empowerment NN cord-011418-hy8xmtiq 38 46 . . . cord-011418-hy8xmtiq 39 1 Pain pain NN cord-011418-hy8xmtiq 39 2 and and CC cord-011418-hy8xmtiq 39 3 agitation agitation NN cord-011418-hy8xmtiq 39 4 are be VBP cord-011418-hy8xmtiq 39 5 prevalent prevalent JJ cord-011418-hy8xmtiq 39 6 issues issue NNS cord-011418-hy8xmtiq 39 7 for for IN cord-011418-hy8xmtiq 39 8 pediatric pediatric JJ cord-011418-hy8xmtiq 39 9 patients patient NNS cord-011418-hy8xmtiq 39 10 during during IN cord-011418-hy8xmtiq 39 11 critical critical JJ cord-011418-hy8xmtiq 39 12 illness illness NN cord-011418-hy8xmtiq 39 13 , , , cord-011418-hy8xmtiq 39 14 and and CC cord-011418-hy8xmtiq 39 15 the the DT cord-011418-hy8xmtiq 39 16 overall overall JJ cord-011418-hy8xmtiq 39 17 goal goal NN cord-011418-hy8xmtiq 39 18 of of IN cord-011418-hy8xmtiq 39 19 pain pain NN cord-011418-hy8xmtiq 39 20 management management NN cord-011418-hy8xmtiq 39 21 within within IN cord-011418-hy8xmtiq 39 22 the the DT cord-011418-hy8xmtiq 39 23 PICU PICU NNP cord-011418-hy8xmtiq 39 24 should should MD cord-011418-hy8xmtiq 39 25 be be VB cord-011418-hy8xmtiq 39 26 to to TO cord-011418-hy8xmtiq 39 27 maintain maintain VB cord-011418-hy8xmtiq 39 28 children child NNS cord-011418-hy8xmtiq 39 29 in in IN cord-011418-hy8xmtiq 39 30 a a DT cord-011418-hy8xmtiq 39 31 calm calm JJ cord-011418-hy8xmtiq 39 32 , , , cord-011418-hy8xmtiq 39 33 comfortable comfortable JJ cord-011418-hy8xmtiq 39 34 state state NN cord-011418-hy8xmtiq 39 35 that that WDT cord-011418-hy8xmtiq 39 36 minimizes minimize VBZ cord-011418-hy8xmtiq 39 37 pain pain NN cord-011418-hy8xmtiq 39 38 , , , cord-011418-hy8xmtiq 39 39 but but CC cord-011418-hy8xmtiq 39 40 in in IN cord-011418-hy8xmtiq 39 41 which which WDT cord-011418-hy8xmtiq 39 42 the the DT cord-011418-hy8xmtiq 39 43 patient patient NN cord-011418-hy8xmtiq 39 44 is be VBZ cord-011418-hy8xmtiq 39 45 also also RB cord-011418-hy8xmtiq 39 46 able able JJ cord-011418-hy8xmtiq 39 47 to to TO cord-011418-hy8xmtiq 39 48 remain remain VB cord-011418-hy8xmtiq 39 49 alert alert JJ cord-011418-hy8xmtiq 39 50 and and CC cord-011418-hy8xmtiq 39 51 lucid lucid JJ cord-011418-hy8xmtiq 39 52 during during IN cord-011418-hy8xmtiq 39 53 recovery recovery NN cord-011418-hy8xmtiq 39 54 . . . cord-011418-hy8xmtiq 40 1 A a DT cord-011418-hy8xmtiq 40 2 key key JJ cord-011418-hy8xmtiq 40 3 first first JJ cord-011418-hy8xmtiq 40 4 step step NN cord-011418-hy8xmtiq 40 5 in in IN cord-011418-hy8xmtiq 40 6 managing manage VBG cord-011418-hy8xmtiq 40 7 pain pain NN cord-011418-hy8xmtiq 40 8 is be VBZ cord-011418-hy8xmtiq 40 9 to to TO cord-011418-hy8xmtiq 40 10 correctly correctly RB cord-011418-hy8xmtiq 40 11 assess assess VB cord-011418-hy8xmtiq 40 12 a a DT cord-011418-hy8xmtiq 40 13 patient patient NN cord-011418-hy8xmtiq 40 14 's 's POS cord-011418-hy8xmtiq 40 15 pain pain NN cord-011418-hy8xmtiq 40 16 level level NN cord-011418-hy8xmtiq 40 17 . . . cord-011418-hy8xmtiq 41 1 Self self NN cord-011418-hy8xmtiq 41 2 - - HYPH cord-011418-hy8xmtiq 41 3 report report NN cord-011418-hy8xmtiq 41 4 is be VBZ cord-011418-hy8xmtiq 41 5 a a DT cord-011418-hy8xmtiq 41 6 reliable reliable JJ cord-011418-hy8xmtiq 41 7 indicator indicator NN cord-011418-hy8xmtiq 41 8 of of IN cord-011418-hy8xmtiq 41 9 pain pain NN cord-011418-hy8xmtiq 41 10 ; ; : cord-011418-hy8xmtiq 41 11 however however RB cord-011418-hy8xmtiq 41 12 , , , cord-011418-hy8xmtiq 41 13 it -PRON- PRP cord-011418-hy8xmtiq 41 14 has have VBZ cord-011418-hy8xmtiq 41 15 been be VBN cord-011418-hy8xmtiq 41 16 shown show VBN cord-011418-hy8xmtiq 41 17 that that IN cord-011418-hy8xmtiq 41 18 a a DT cord-011418-hy8xmtiq 41 19 large large JJ cord-011418-hy8xmtiq 41 20 proportion proportion NN cord-011418-hy8xmtiq 41 21 of of IN cord-011418-hy8xmtiq 41 22 pediatric pediatric JJ cord-011418-hy8xmtiq 41 23 patients patient NNS cord-011418-hy8xmtiq 41 24 in in IN cord-011418-hy8xmtiq 41 25 the the DT cord-011418-hy8xmtiq 41 26 PICU PICU NNP cord-011418-hy8xmtiq 41 27 are be VBP cord-011418-hy8xmtiq 41 28 unable unable JJ cord-011418-hy8xmtiq 41 29 to to TO cord-011418-hy8xmtiq 41 30 self self NN cord-011418-hy8xmtiq 41 31 - - HYPH cord-011418-hy8xmtiq 41 32 report report VB cord-011418-hy8xmtiq 41 33 their -PRON- PRP$ cord-011418-hy8xmtiq 41 34 pain pain NN cord-011418-hy8xmtiq 41 35 [ [ -LRB- cord-011418-hy8xmtiq 41 36 20 20 CD cord-011418-hy8xmtiq 41 37 ] ] -RRB- cord-011418-hy8xmtiq 41 38 . . . cord-011418-hy8xmtiq 42 1 The the DT cord-011418-hy8xmtiq 42 2 heterogenous heterogenous JJ cord-011418-hy8xmtiq 42 3 ages age NNS cord-011418-hy8xmtiq 42 4 and and CC cord-011418-hy8xmtiq 42 5 developmental developmental JJ cord-011418-hy8xmtiq 42 6 levels level NNS cord-011418-hy8xmtiq 42 7 of of IN cord-011418-hy8xmtiq 42 8 the the DT cord-011418-hy8xmtiq 42 9 patients patient NNS cord-011418-hy8xmtiq 42 10 , , , cord-011418-hy8xmtiq 42 11 in in IN cord-011418-hy8xmtiq 42 12 addition addition NN cord-011418-hy8xmtiq 42 13 to to IN cord-011418-hy8xmtiq 42 14 the the DT cord-011418-hy8xmtiq 42 15 use use NN cord-011418-hy8xmtiq 42 16 of of IN cord-011418-hy8xmtiq 42 17 invasive invasive JJ cord-011418-hy8xmtiq 42 18 support support NN cord-011418-hy8xmtiq 42 19 , , , cord-011418-hy8xmtiq 42 20 can can MD cord-011418-hy8xmtiq 42 21 make make VB cord-011418-hy8xmtiq 42 22 adequate adequate JJ cord-011418-hy8xmtiq 42 23 pain pain NN cord-011418-hy8xmtiq 42 24 assessment assessment NN cord-011418-hy8xmtiq 42 25 challenging challenge VBG cord-011418-hy8xmtiq 42 26 . . . cord-011418-hy8xmtiq 43 1 To to TO cord-011418-hy8xmtiq 43 2 ameliorate ameliorate VB cord-011418-hy8xmtiq 43 3 this this DT cord-011418-hy8xmtiq 43 4 , , , cord-011418-hy8xmtiq 43 5 a a DT cord-011418-hy8xmtiq 43 6 reliable reliable JJ cord-011418-hy8xmtiq 43 7 and and CC cord-011418-hy8xmtiq 43 8 valid valid JJ cord-011418-hy8xmtiq 43 9 pain pain NN cord-011418-hy8xmtiq 43 10 scale scale NN cord-011418-hy8xmtiq 43 11 , , , cord-011418-hy8xmtiq 43 12 appropriate appropriate JJ cord-011418-hy8xmtiq 43 13 for for IN cord-011418-hy8xmtiq 43 14 different different JJ cord-011418-hy8xmtiq 43 15 ages age NNS cord-011418-hy8xmtiq 43 16 , , , cord-011418-hy8xmtiq 43 17 should should MD cord-011418-hy8xmtiq 43 18 be be VB cord-011418-hy8xmtiq 43 19 used use VBN cord-011418-hy8xmtiq 43 20 for for IN cord-011418-hy8xmtiq 43 21 assessing assess VBG cord-011418-hy8xmtiq 43 22 pain pain NN cord-011418-hy8xmtiq 43 23 and and CC cord-011418-hy8xmtiq 43 24 titrating titrate VBG cord-011418-hy8xmtiq 43 25 medications medication NNS cord-011418-hy8xmtiq 43 26 when when WRB cord-011418-hy8xmtiq 43 27 self self NN cord-011418-hy8xmtiq 43 28 - - HYPH cord-011418-hy8xmtiq 43 29 reporting reporting NN cord-011418-hy8xmtiq 43 30 is be VBZ cord-011418-hy8xmtiq 43 31 not not RB cord-011418-hy8xmtiq 43 32 possible possible JJ cord-011418-hy8xmtiq 43 33 . . . cord-011418-hy8xmtiq 44 1 The the DT cord-011418-hy8xmtiq 44 2 choice choice NN cord-011418-hy8xmtiq 44 3 of of IN cord-011418-hy8xmtiq 44 4 pain pain NN cord-011418-hy8xmtiq 44 5 scale scale NN cord-011418-hy8xmtiq 44 6 used use VBN cord-011418-hy8xmtiq 44 7 will will MD cord-011418-hy8xmtiq 44 8 depend depend VB cord-011418-hy8xmtiq 44 9 on on IN cord-011418-hy8xmtiq 44 10 patient patient JJ cord-011418-hy8xmtiq 44 11 age age NN cord-011418-hy8xmtiq 44 12 and and CC cord-011418-hy8xmtiq 44 13 the the DT cord-011418-hy8xmtiq 44 14 verbal verbal JJ cord-011418-hy8xmtiq 44 15 and and CC cord-011418-hy8xmtiq 44 16 cognitive cognitive JJ cord-011418-hy8xmtiq 44 17 capacity capacity NN cord-011418-hy8xmtiq 44 18 of of IN cord-011418-hy8xmtiq 44 19 the the DT cord-011418-hy8xmtiq 44 20 patient patient NN cord-011418-hy8xmtiq 44 21 . . . cord-011418-hy8xmtiq 45 1 In in IN cord-011418-hy8xmtiq 45 2 pediatrics pediatric NNS cord-011418-hy8xmtiq 45 3 , , , cord-011418-hy8xmtiq 45 4 validated validate VBD cord-011418-hy8xmtiq 45 5 pain pain NN cord-011418-hy8xmtiq 45 6 scales scale NNS cord-011418-hy8xmtiq 45 7 include include VBP cord-011418-hy8xmtiq 45 8 the the DT cord-011418-hy8xmtiq 45 9 Face Face NNP cord-011418-hy8xmtiq 45 10 , , , cord-011418-hy8xmtiq 45 11 Legs leg NNS cord-011418-hy8xmtiq 45 12 , , , cord-011418-hy8xmtiq 45 13 Activity activity NN cord-011418-hy8xmtiq 45 14 , , , cord-011418-hy8xmtiq 45 15 Crying crying NN cord-011418-hy8xmtiq 45 16 , , , cord-011418-hy8xmtiq 45 17 Consolability Consolability NNP cord-011418-hy8xmtiq 45 18 ( ( -LRB- cord-011418-hy8xmtiq 45 19 FLACC FLACC NNP cord-011418-hy8xmtiq 45 20 ) ) -RRB- cord-011418-hy8xmtiq 45 21 Scale scale NN cord-011418-hy8xmtiq 45 22 for for IN cord-011418-hy8xmtiq 45 23 nonverbal nonverbal JJ cord-011418-hy8xmtiq 45 24 children child NNS cord-011418-hy8xmtiq 45 25 0 0 CD cord-011418-hy8xmtiq 45 26 to to IN cord-011418-hy8xmtiq 45 27 6 6 CD cord-011418-hy8xmtiq 45 28 years year NNS cord-011418-hy8xmtiq 45 29 of of IN cord-011418-hy8xmtiq 45 30 age age NN cord-011418-hy8xmtiq 45 31 [ [ -LRB- cord-011418-hy8xmtiq 45 32 21 21 CD cord-011418-hy8xmtiq 45 33 ] ] -RRB- cord-011418-hy8xmtiq 45 34 , , , cord-011418-hy8xmtiq 45 35 the the DT cord-011418-hy8xmtiq 45 36 Individualized Individualized NNP cord-011418-hy8xmtiq 45 37 Numeric Numeric NNP cord-011418-hy8xmtiq 45 38 Rating rating NN cord-011418-hy8xmtiq 45 39 Scale scale NN cord-011418-hy8xmtiq 45 40 ( ( -LRB- cord-011418-hy8xmtiq 45 41 NRS NRS NNP cord-011418-hy8xmtiq 45 42 ) ) -RRB- cord-011418-hy8xmtiq 45 43 for for IN cord-011418-hy8xmtiq 45 44 nonverbal nonverbal NNS cord-011418-hy8xmtiq 45 45 cognitively cognitively RB cord-011418-hy8xmtiq 45 46 impaired impaired JJ cord-011418-hy8xmtiq 45 47 children child NNS cord-011418-hy8xmtiq 45 48 aged age VBN cord-011418-hy8xmtiq 45 49 6 6 CD cord-011418-hy8xmtiq 45 50 years year NNS cord-011418-hy8xmtiq 45 51 and and CC cord-011418-hy8xmtiq 45 52 older old JJR cord-011418-hy8xmtiq 45 53 [ [ -LRB- cord-011418-hy8xmtiq 45 54 22 22 CD cord-011418-hy8xmtiq 45 55 ] ] -RRB- cord-011418-hy8xmtiq 45 56 , , , cord-011418-hy8xmtiq 45 57 and and CC cord-011418-hy8xmtiq 45 58 the the DT cord-011418-hy8xmtiq 45 59 Wong Wong NNP cord-011418-hy8xmtiq 45 60 - - HYPH cord-011418-hy8xmtiq 45 61 Baker Baker NNP cord-011418-hy8xmtiq 45 62 Faces face VBZ cord-011418-hy8xmtiq 45 63 Pain pain NN cord-011418-hy8xmtiq 45 64 Scale scale NN cord-011418-hy8xmtiq 45 65 ( ( -LRB- cord-011418-hy8xmtiq 45 66 FACES faces NN cord-011418-hy8xmtiq 45 67 ) ) -RRB- cord-011418-hy8xmtiq 45 68 for for IN cord-011418-hy8xmtiq 45 69 verbal verbal JJ cord-011418-hy8xmtiq 45 70 children child NNS cord-011418-hy8xmtiq 45 71 3 3 CD cord-011418-hy8xmtiq 45 72 years year NNS cord-011418-hy8xmtiq 45 73 or or CC cord-011418-hy8xmtiq 45 74 older old JJR cord-011418-hy8xmtiq 45 75 [ [ -LRB- cord-011418-hy8xmtiq 45 76 23 23 CD cord-011418-hy8xmtiq 45 77 ] ] -RRB- cord-011418-hy8xmtiq 45 78 . . . cord-011418-hy8xmtiq 46 1 In in IN cord-011418-hy8xmtiq 46 2 each each DT cord-011418-hy8xmtiq 46 3 of of IN cord-011418-hy8xmtiq 46 4 these these DT cord-011418-hy8xmtiq 46 5 scales scale NNS cord-011418-hy8xmtiq 46 6 , , , cord-011418-hy8xmtiq 46 7 a a DT cord-011418-hy8xmtiq 46 8 score score NN cord-011418-hy8xmtiq 46 9 of of IN cord-011418-hy8xmtiq 46 10 0 0 CD cord-011418-hy8xmtiq 46 11 to to IN cord-011418-hy8xmtiq 46 12 10 10 CD cord-011418-hy8xmtiq 46 13 can can MD cord-011418-hy8xmtiq 46 14 be be VB cord-011418-hy8xmtiq 46 15 assigned assign VBN cord-011418-hy8xmtiq 46 16 , , , cord-011418-hy8xmtiq 46 17 with with IN cord-011418-hy8xmtiq 46 18 higher high JJR cord-011418-hy8xmtiq 46 19 scores score NNS cord-011418-hy8xmtiq 46 20 indicating indicate VBG cord-011418-hy8xmtiq 46 21 more more JJR cord-011418-hy8xmtiq 46 22 pain pain NN cord-011418-hy8xmtiq 46 23 . . . cord-011418-hy8xmtiq 47 1 In in IN cord-011418-hy8xmtiq 47 2 addition addition NN cord-011418-hy8xmtiq 47 3 to to IN cord-011418-hy8xmtiq 47 4 the the DT cord-011418-hy8xmtiq 47 5 use use NN cord-011418-hy8xmtiq 47 6 of of IN cord-011418-hy8xmtiq 47 7 medications medication NNS cord-011418-hy8xmtiq 47 8 to to TO cord-011418-hy8xmtiq 47 9 treat treat VB cord-011418-hy8xmtiq 47 10 acute acute JJ cord-011418-hy8xmtiq 47 11 pain pain NN cord-011418-hy8xmtiq 47 12 , , , cord-011418-hy8xmtiq 47 13 nonpharmacologic nonpharmacologic JJ cord-011418-hy8xmtiq 47 14 interventions intervention NNS cord-011418-hy8xmtiq 47 15 should should MD cord-011418-hy8xmtiq 47 16 be be VB cord-011418-hy8xmtiq 47 17 considered consider VBN cord-011418-hy8xmtiq 47 18 as as IN cord-011418-hy8xmtiq 47 19 adjuncts adjunct NNS cord-011418-hy8xmtiq 47 20 . . . cord-011418-hy8xmtiq 48 1 Examples example NNS cord-011418-hy8xmtiq 48 2 include include VBP cord-011418-hy8xmtiq 48 3 repositioning reposition VBG cord-011418-hy8xmtiq 48 4 , , , cord-011418-hy8xmtiq 48 5 distraction distraction NN cord-011418-hy8xmtiq 48 6 , , , cord-011418-hy8xmtiq 48 7 increasing increase VBG cord-011418-hy8xmtiq 48 8 caregiver caregiver NN cord-011418-hy8xmtiq 48 9 presence presence NN cord-011418-hy8xmtiq 48 10 , , , cord-011418-hy8xmtiq 48 11 heat heat NN cord-011418-hy8xmtiq 48 12 / / SYM cord-011418-hy8xmtiq 48 13 cold cold JJ cord-011418-hy8xmtiq 48 14 compresses compress NNS cord-011418-hy8xmtiq 48 15 , , , cord-011418-hy8xmtiq 48 16 or or CC cord-011418-hy8xmtiq 48 17 the the DT cord-011418-hy8xmtiq 48 18 use use NN cord-011418-hy8xmtiq 48 19 of of IN cord-011418-hy8xmtiq 48 20 massage massage NN cord-011418-hy8xmtiq 48 21 therapy therapy NN cord-011418-hy8xmtiq 48 22 , , , cord-011418-hy8xmtiq 48 23 music music NN cord-011418-hy8xmtiq 48 24 therapy therapy NN cord-011418-hy8xmtiq 48 25 , , , cord-011418-hy8xmtiq 48 26 and and CC cord-011418-hy8xmtiq 48 27 child child NN cord-011418-hy8xmtiq 48 28 life life NN cord-011418-hy8xmtiq 48 29 therapy therapy NN cord-011418-hy8xmtiq 48 30 [ [ -LRB- cord-011418-hy8xmtiq 48 31 24 24 CD cord-011418-hy8xmtiq 48 32 ] ] -RRB- cord-011418-hy8xmtiq 48 33 [ [ -LRB- cord-011418-hy8xmtiq 48 34 25 25 CD cord-011418-hy8xmtiq 48 35 ] ] -RRB- cord-011418-hy8xmtiq 48 36 [ [ -LRB- cord-011418-hy8xmtiq 48 37 26 26 CD cord-011418-hy8xmtiq 48 38 ] ] -RRB- cord-011418-hy8xmtiq 48 39 . . . cord-011418-hy8xmtiq 49 1 Tips tip NNS cord-011418-hy8xmtiq 49 2 for for IN cord-011418-hy8xmtiq 49 3 Implementation implementation NN cord-011418-hy8xmtiq 49 4 Start Start NNP cord-011418-hy8xmtiq 49 5 by by IN cord-011418-hy8xmtiq 49 6 choosing choose VBG cord-011418-hy8xmtiq 49 7 a a DT cord-011418-hy8xmtiq 49 8 validated validate VBN cord-011418-hy8xmtiq 49 9 assessment assessment NN cord-011418-hy8xmtiq 49 10 tool tool NN cord-011418-hy8xmtiq 49 11 to to TO cord-011418-hy8xmtiq 49 12 systematically systematically RB cord-011418-hy8xmtiq 49 13 evaluate evaluate VB cord-011418-hy8xmtiq 49 14 levels level NNS cord-011418-hy8xmtiq 49 15 of of IN cord-011418-hy8xmtiq 49 16 pain pain NN cord-011418-hy8xmtiq 49 17 ( ( -LRB- cord-011418-hy8xmtiq 49 18 in in IN cord-011418-hy8xmtiq 49 19 pediatrics pediatric NNS cord-011418-hy8xmtiq 50 1 , , , cord-011418-hy8xmtiq 50 2 this this DT cord-011418-hy8xmtiq 50 3 includes include VBZ cord-011418-hy8xmtiq 50 4 the the DT cord-011418-hy8xmtiq 50 5 NRS NRS NNP cord-011418-hy8xmtiq 50 6 , , , cord-011418-hy8xmtiq 50 7 FACES faces NN cord-011418-hy8xmtiq 50 8 , , , cord-011418-hy8xmtiq 50 9 and and CC cord-011418-hy8xmtiq 50 10 FLACC FLACC NNP cord-011418-hy8xmtiq 50 11 Scales Scales NNPS cord-011418-hy8xmtiq 50 12 ) ) -RRB- cord-011418-hy8xmtiq 50 13 and and CC cord-011418-hy8xmtiq 50 14 incorporate incorporate VB cord-011418-hy8xmtiq 50 15 this this DT cord-011418-hy8xmtiq 50 16 into into IN cord-011418-hy8xmtiq 50 17 daily daily JJ cord-011418-hy8xmtiq 50 18 nursing nursing NN cord-011418-hy8xmtiq 50 19 assessments assessment NNS cord-011418-hy8xmtiq 50 20 . . . cord-011418-hy8xmtiq 51 1 Discuss discuss VB cord-011418-hy8xmtiq 51 2 among among IN cord-011418-hy8xmtiq 51 3 key key JJ cord-011418-hy8xmtiq 51 4 stakeholders stakeholder NNS cord-011418-hy8xmtiq 51 5 how how WRB cord-011418-hy8xmtiq 51 6 higher high JJR cord-011418-hy8xmtiq 51 7 pain pain NN cord-011418-hy8xmtiq 51 8 scores score NNS cord-011418-hy8xmtiq 51 9 should should MD cord-011418-hy8xmtiq 51 10 be be VB cord-011418-hy8xmtiq 51 11 addressed address VBN cord-011418-hy8xmtiq 51 12 with with IN cord-011418-hy8xmtiq 51 13 medications medication NNS cord-011418-hy8xmtiq 51 14 and and CC cord-011418-hy8xmtiq 51 15 nonpharmacologic nonpharmacologic JJ cord-011418-hy8xmtiq 51 16 interventions intervention NNS cord-011418-hy8xmtiq 51 17 and and CC cord-011418-hy8xmtiq 51 18 be be VB cord-011418-hy8xmtiq 51 19 sure sure JJ cord-011418-hy8xmtiq 51 20 to to TO cord-011418-hy8xmtiq 51 21 include include VB cord-011418-hy8xmtiq 51 22 reassessment reassessment NN cord-011418-hy8xmtiq 51 23 of of IN cord-011418-hy8xmtiq 51 24 pain pain NN cord-011418-hy8xmtiq 51 25 scores score NNS cord-011418-hy8xmtiq 51 26 after after IN cord-011418-hy8xmtiq 51 27 intervention intervention NN cord-011418-hy8xmtiq 51 28 . . . cord-011418-hy8xmtiq 52 1 Prolonged prolonged JJ cord-011418-hy8xmtiq 52 2 mechanical mechanical JJ cord-011418-hy8xmtiq 52 3 ventilation ventilation NN cord-011418-hy8xmtiq 52 4 is be VBZ cord-011418-hy8xmtiq 52 5 associated associate VBN cord-011418-hy8xmtiq 52 6 with with IN cord-011418-hy8xmtiq 52 7 increased increase VBN cord-011418-hy8xmtiq 52 8 patient patient JJ cord-011418-hy8xmtiq 52 9 morbidity morbidity NN cord-011418-hy8xmtiq 52 10 and and CC cord-011418-hy8xmtiq 52 11 mortality mortality NN cord-011418-hy8xmtiq 52 12 and and CC cord-011418-hy8xmtiq 52 13 there there EX cord-011418-hy8xmtiq 52 14 is be VBZ cord-011418-hy8xmtiq 52 15 evidence evidence NN cord-011418-hy8xmtiq 52 16 that that IN cord-011418-hy8xmtiq 52 17 reducing reduce VBG cord-011418-hy8xmtiq 52 18 the the DT cord-011418-hy8xmtiq 52 19 duration duration NN cord-011418-hy8xmtiq 52 20 of of IN cord-011418-hy8xmtiq 52 21 mechanical mechanical JJ cord-011418-hy8xmtiq 52 22 ventilation ventilation NN cord-011418-hy8xmtiq 52 23 through through IN cord-011418-hy8xmtiq 52 24 ventilator ventilator NN cord-011418-hy8xmtiq 52 25 weaning wean VBG cord-011418-hy8xmtiq 52 26 protocols protocol NNS cord-011418-hy8xmtiq 52 27 can can MD cord-011418-hy8xmtiq 52 28 improve improve VB cord-011418-hy8xmtiq 52 29 clinical clinical JJ cord-011418-hy8xmtiq 52 30 outcomes outcome NNS cord-011418-hy8xmtiq 52 31 [ [ -LRB- cord-011418-hy8xmtiq 52 32 27 27 CD cord-011418-hy8xmtiq 52 33 , , , cord-011418-hy8xmtiq 52 34 28• 28• CD cord-011418-hy8xmtiq 52 35 ] ] -RRB- cord-011418-hy8xmtiq 52 36 . . . cord-011418-hy8xmtiq 53 1 Therefore therefore RB cord-011418-hy8xmtiq 53 2 , , , cord-011418-hy8xmtiq 53 3 it -PRON- PRP cord-011418-hy8xmtiq 53 4 is be VBZ cord-011418-hy8xmtiq 53 5 imperative imperative JJ cord-011418-hy8xmtiq 53 6 to to TO cord-011418-hy8xmtiq 53 7 recognize recognize VB cord-011418-hy8xmtiq 53 8 early early RB cord-011418-hy8xmtiq 53 9 those those DT cord-011418-hy8xmtiq 53 10 patients patient NNS cord-011418-hy8xmtiq 53 11 who who WP cord-011418-hy8xmtiq 53 12 are be VBP cord-011418-hy8xmtiq 53 13 ready ready JJ cord-011418-hy8xmtiq 53 14 for for IN cord-011418-hy8xmtiq 53 15 discontinuation discontinuation NN cord-011418-hy8xmtiq 53 16 of of IN cord-011418-hy8xmtiq 53 17 mechanical mechanical JJ cord-011418-hy8xmtiq 53 18 Family Family NNP cord-011418-hy8xmtiq 53 19 engagement engagement NN cord-011418-hy8xmtiq 53 20 and and CC cord-011418-hy8xmtiq 53 21 empowerment empowerment NN cord-011418-hy8xmtiq 53 22 respiratory respiratory JJ cord-011418-hy8xmtiq 53 23 support support NN cord-011418-hy8xmtiq 53 24 . . . cord-011418-hy8xmtiq 54 1 A a DT cord-011418-hy8xmtiq 54 2 spontaneous spontaneous JJ cord-011418-hy8xmtiq 54 3 breathing breathing NN cord-011418-hy8xmtiq 54 4 trial trial NN cord-011418-hy8xmtiq 54 5 ( ( -LRB- cord-011418-hy8xmtiq 54 6 SBT SBT NNP cord-011418-hy8xmtiq 54 7 ) ) -RRB- cord-011418-hy8xmtiq 54 8 is be VBZ cord-011418-hy8xmtiq 54 9 a a DT cord-011418-hy8xmtiq 54 10 systematic systematic JJ cord-011418-hy8xmtiq 54 11 clinical clinical JJ cord-011418-hy8xmtiq 54 12 assessment assessment NN cord-011418-hy8xmtiq 54 13 of of IN cord-011418-hy8xmtiq 54 14 the the DT cord-011418-hy8xmtiq 54 15 respiratory respiratory JJ cord-011418-hy8xmtiq 54 16 pattern pattern NN cord-011418-hy8xmtiq 54 17 , , , cord-011418-hy8xmtiq 54 18 adequacy adequacy NN cord-011418-hy8xmtiq 54 19 of of IN cord-011418-hy8xmtiq 54 20 gas gas NN cord-011418-hy8xmtiq 54 21 exchange exchange NN cord-011418-hy8xmtiq 54 22 , , , cord-011418-hy8xmtiq 54 23 hemodynamic hemodynamic JJ cord-011418-hy8xmtiq 54 24 stability stability NN cord-011418-hy8xmtiq 54 25 , , , cord-011418-hy8xmtiq 54 26 and and CC cord-011418-hy8xmtiq 54 27 subjective subjective JJ cord-011418-hy8xmtiq 54 28 patient patient JJ cord-011418-hy8xmtiq 54 29 comfort comfort NN cord-011418-hy8xmtiq 54 30 that that WDT cord-011418-hy8xmtiq 54 31 can can MD cord-011418-hy8xmtiq 54 32 be be VB cord-011418-hy8xmtiq 54 33 used use VBN cord-011418-hy8xmtiq 54 34 to to TO cord-011418-hy8xmtiq 54 35 prompt prompt VB cord-011418-hy8xmtiq 54 36 consideration consideration NN cord-011418-hy8xmtiq 54 37 for for IN cord-011418-hy8xmtiq 54 38 ventilator ventilator NN cord-011418-hy8xmtiq 54 39 discontinuation discontinuation NN cord-011418-hy8xmtiq 54 40 [ [ -LRB- cord-011418-hy8xmtiq 54 41 29 29 CD cord-011418-hy8xmtiq 54 42 , , , cord-011418-hy8xmtiq 54 43 30 30 CD cord-011418-hy8xmtiq 54 44 ] ] -RRB- cord-011418-hy8xmtiq 54 45 . . . cord-011418-hy8xmtiq 55 1 In in IN cord-011418-hy8xmtiq 55 2 practice practice NN cord-011418-hy8xmtiq 55 3 , , , cord-011418-hy8xmtiq 55 4 systematic systematic JJ cord-011418-hy8xmtiq 55 5 usage usage NN cord-011418-hy8xmtiq 55 6 of of IN cord-011418-hy8xmtiq 55 7 SBT SBT NNP cord-011418-hy8xmtiq 55 8 leads lead VBZ cord-011418-hy8xmtiq 55 9 to to IN cord-011418-hy8xmtiq 55 10 earlier early JJR cord-011418-hy8xmtiq 55 11 discontinuation discontinuation NN cord-011418-hy8xmtiq 55 12 of of IN cord-011418-hy8xmtiq 55 13 mechanical mechanical JJ cord-011418-hy8xmtiq 55 14 ventilation ventilation NN cord-011418-hy8xmtiq 55 15 and and CC cord-011418-hy8xmtiq 55 16 it -PRON- PRP cord-011418-hy8xmtiq 55 17 has have VBZ cord-011418-hy8xmtiq 55 18 been be VBN cord-011418-hy8xmtiq 55 19 shown show VBN cord-011418-hy8xmtiq 55 20 that that IN cord-011418-hy8xmtiq 55 21 up up IN cord-011418-hy8xmtiq 55 22 to to TO cord-011418-hy8xmtiq 55 23 77 77 CD cord-011418-hy8xmtiq 55 24 % % NN cord-011418-hy8xmtiq 55 25 of of IN cord-011418-hy8xmtiq 55 26 critically critically RB cord-011418-hy8xmtiq 55 27 ill ill JJ cord-011418-hy8xmtiq 55 28 adult adult NN cord-011418-hy8xmtiq 55 29 patients patient NNS cord-011418-hy8xmtiq 55 30 who who WP cord-011418-hy8xmtiq 55 31 tolerated tolerate VBD cord-011418-hy8xmtiq 55 32 SBT SBT NNP cord-011418-hy8xmtiq 55 33 were be VBD cord-011418-hy8xmtiq 55 34 able able JJ cord-011418-hy8xmtiq 55 35 to to TO cord-011418-hy8xmtiq 55 36 be be VB cord-011418-hy8xmtiq 55 37 successfully successfully RB cord-011418-hy8xmtiq 55 38 extubated extubate VBN cord-011418-hy8xmtiq 55 39 [ [ -LRB- cord-011418-hy8xmtiq 55 40 30 30 CD cord-011418-hy8xmtiq 55 41 ] ] -RRB- cord-011418-hy8xmtiq 55 42 . . . cord-011418-hy8xmtiq 56 1 While while IN cord-011418-hy8xmtiq 56 2 similar similar JJ cord-011418-hy8xmtiq 56 3 outcome outcome NN cord-011418-hy8xmtiq 56 4 data datum NNS cord-011418-hy8xmtiq 56 5 for for IN cord-011418-hy8xmtiq 56 6 SBT SBT NNP cord-011418-hy8xmtiq 56 7 does do VBZ cord-011418-hy8xmtiq 56 8 not not RB cord-011418-hy8xmtiq 56 9 yet yet RB cord-011418-hy8xmtiq 56 10 exist exist VB cord-011418-hy8xmtiq 56 11 in in IN cord-011418-hy8xmtiq 56 12 pediatrics pediatric NNS cord-011418-hy8xmtiq 56 13 , , , cord-011418-hy8xmtiq 56 14 and and CC cord-011418-hy8xmtiq 56 15 there there EX cord-011418-hy8xmtiq 56 16 remains remain VBZ cord-011418-hy8xmtiq 56 17 controversy controversy NN cord-011418-hy8xmtiq 56 18 over over IN cord-011418-hy8xmtiq 56 19 both both CC cord-011418-hy8xmtiq 56 20 the the DT cord-011418-hy8xmtiq 56 21 optimal optimal JJ cord-011418-hy8xmtiq 56 22 technique technique NN cord-011418-hy8xmtiq 56 23 to to TO cord-011418-hy8xmtiq 56 24 perform perform VB cord-011418-hy8xmtiq 56 25 an an DT cord-011418-hy8xmtiq 56 26 SBT SBT NNP cord-011418-hy8xmtiq 56 27 and and CC cord-011418-hy8xmtiq 56 28 the the DT cord-011418-hy8xmtiq 56 29 criteria criterion NNS cord-011418-hy8xmtiq 56 30 defining define VBG cord-011418-hy8xmtiq 56 31 a a DT cord-011418-hy8xmtiq 56 32 successful successful JJ cord-011418-hy8xmtiq 56 33 SBT SBT NNP cord-011418-hy8xmtiq 56 34 , , , cord-011418-hy8xmtiq 56 35 investigation investigation NN cord-011418-hy8xmtiq 56 36 is be VBZ cord-011418-hy8xmtiq 56 37 currently currently RB cord-011418-hy8xmtiq 56 38 underway underway JJ cord-011418-hy8xmtiq 56 39 in in IN cord-011418-hy8xmtiq 56 40 pediatrics pediatric NNS cord-011418-hy8xmtiq 56 41 . . . cord-011418-hy8xmtiq 57 1 Patients patient NNS cord-011418-hy8xmtiq 57 2 requiring require VBG cord-011418-hy8xmtiq 57 3 mechanical mechanical JJ cord-011418-hy8xmtiq 57 4 ventilation ventilation NN cord-011418-hy8xmtiq 57 5 are be VBP cord-011418-hy8xmtiq 57 6 often often RB cord-011418-hy8xmtiq 57 7 maintained maintain VBN cord-011418-hy8xmtiq 57 8 on on IN cord-011418-hy8xmtiq 57 9 continuous continuous JJ cord-011418-hy8xmtiq 57 10 sedative sedative JJ cord-011418-hy8xmtiq 57 11 infusions infusion NNS cord-011418-hy8xmtiq 57 12 ; ; : cord-011418-hy8xmtiq 57 13 thus thus RB cord-011418-hy8xmtiq 57 14 , , , cord-011418-hy8xmtiq 57 15 it -PRON- PRP cord-011418-hy8xmtiq 57 16 is be VBZ cord-011418-hy8xmtiq 57 17 important important JJ cord-011418-hy8xmtiq 57 18 to to TO cord-011418-hy8xmtiq 57 19 pay pay VB cord-011418-hy8xmtiq 57 20 attention attention NN cord-011418-hy8xmtiq 57 21 to to IN cord-011418-hy8xmtiq 57 22 the the DT cord-011418-hy8xmtiq 57 23 effects effect NNS cord-011418-hy8xmtiq 57 24 of of IN cord-011418-hy8xmtiq 57 25 sedation sedation NN cord-011418-hy8xmtiq 57 26 on on IN cord-011418-hy8xmtiq 57 27 respiratory respiratory JJ cord-011418-hy8xmtiq 57 28 drive drive NN cord-011418-hy8xmtiq 57 29 and and CC cord-011418-hy8xmtiq 57 30 how how WRB cord-011418-hy8xmtiq 57 31 the the DT cord-011418-hy8xmtiq 57 32 level level NN cord-011418-hy8xmtiq 57 33 of of IN cord-011418-hy8xmtiq 57 34 sedation sedation NN cord-011418-hy8xmtiq 57 35 may may MD cord-011418-hy8xmtiq 57 36 affect affect VB cord-011418-hy8xmtiq 57 37 a a DT cord-011418-hy8xmtiq 57 38 patient patient NN cord-011418-hy8xmtiq 57 39 's 's POS cord-011418-hy8xmtiq 57 40 success success NN cord-011418-hy8xmtiq 57 41 of of IN cord-011418-hy8xmtiq 57 42 liberation liberation NN cord-011418-hy8xmtiq 57 43 from from IN cord-011418-hy8xmtiq 57 44 mechanical mechanical JJ cord-011418-hy8xmtiq 57 45 ventilation ventilation NN cord-011418-hy8xmtiq 57 46 . . . cord-011418-hy8xmtiq 58 1 Deep deep JJ cord-011418-hy8xmtiq 58 2 sedation sedation NN cord-011418-hy8xmtiq 58 3 has have VBZ cord-011418-hy8xmtiq 58 4 been be VBN cord-011418-hy8xmtiq 58 5 associated associate VBN cord-011418-hy8xmtiq 58 6 with with IN cord-011418-hy8xmtiq 58 7 longer long JJR cord-011418-hy8xmtiq 58 8 duration duration NN cord-011418-hy8xmtiq 58 9 of of IN cord-011418-hy8xmtiq 58 10 mechanical mechanical JJ cord-011418-hy8xmtiq 58 11 ventilation ventilation NN cord-011418-hy8xmtiq 58 12 and and CC cord-011418-hy8xmtiq 58 13 reduced reduce VBD cord-011418-hy8xmtiq 58 14 6-month 6-month CD cord-011418-hy8xmtiq 58 15 survival survival NN cord-011418-hy8xmtiq 58 16 [ [ -LRB- cord-011418-hy8xmtiq 58 17 31 31 CD cord-011418-hy8xmtiq 58 18 ] ] -RRB- cord-011418-hy8xmtiq 58 19 . . . cord-011418-hy8xmtiq 59 1 One one CD cord-011418-hy8xmtiq 59 2 such such JJ cord-011418-hy8xmtiq 59 3 option option NN cord-011418-hy8xmtiq 59 4 to to TO cord-011418-hy8xmtiq 59 5 systematically systematically RB cord-011418-hy8xmtiq 59 6 assess assess VB cord-011418-hy8xmtiq 59 7 a a DT cord-011418-hy8xmtiq 59 8 patient patient NN cord-011418-hy8xmtiq 59 9 's 's POS cord-011418-hy8xmtiq 59 10 sedation sedation NN cord-011418-hy8xmtiq 59 11 requirements requirement NNS cord-011418-hy8xmtiq 59 12 and and CC cord-011418-hy8xmtiq 59 13 ability ability NN cord-011418-hy8xmtiq 59 14 to to TO cord-011418-hy8xmtiq 59 15 be be VB cord-011418-hy8xmtiq 59 16 more more RBR cord-011418-hy8xmtiq 59 17 awake awake JJ cord-011418-hy8xmtiq 59 18 while while IN cord-011418-hy8xmtiq 59 19 mechanically mechanically RB cord-011418-hy8xmtiq 59 20 ventilated ventilate VBN cord-011418-hy8xmtiq 59 21 is be VBZ cord-011418-hy8xmtiq 59 22 through through IN cord-011418-hy8xmtiq 59 23 a a DT cord-011418-hy8xmtiq 59 24 trial trial NN cord-011418-hy8xmtiq 59 25 of of IN cord-011418-hy8xmtiq 59 26 daily daily JJ cord-011418-hy8xmtiq 59 27 sedation sedation NN cord-011418-hy8xmtiq 59 28 interruption interruption NN cord-011418-hy8xmtiq 59 29 , , , cord-011418-hy8xmtiq 59 30 or or CC cord-011418-hy8xmtiq 59 31 a a DT cord-011418-hy8xmtiq 59 32 " " `` cord-011418-hy8xmtiq 59 33 sedation sedation NN cord-011418-hy8xmtiq 59 34 holiday holiday NN cord-011418-hy8xmtiq 59 35 . . . cord-011418-hy8xmtiq 60 1 " " `` cord-011418-hy8xmtiq 60 2 This this DT cord-011418-hy8xmtiq 60 3 daily daily JJ cord-011418-hy8xmtiq 60 4 sedation sedation NN cord-011418-hy8xmtiq 60 5 interruption interruption NN cord-011418-hy8xmtiq 60 6 is be VBZ cord-011418-hy8xmtiq 60 7 often often RB cord-011418-hy8xmtiq 60 8 referred refer VBN cord-011418-hy8xmtiq 60 9 to to IN cord-011418-hy8xmtiq 60 10 as as IN cord-011418-hy8xmtiq 60 11 a a DT cord-011418-hy8xmtiq 60 12 spontaneous spontaneous JJ cord-011418-hy8xmtiq 60 13 awakening awakening NN cord-011418-hy8xmtiq 60 14 trial trial NN cord-011418-hy8xmtiq 60 15 ( ( -LRB- cord-011418-hy8xmtiq 60 16 SAT SAT NNP cord-011418-hy8xmtiq 60 17 ) ) -RRB- cord-011418-hy8xmtiq 60 18 . . . cord-011418-hy8xmtiq 61 1 A a DT cord-011418-hy8xmtiq 61 2 SAT SAT NNP cord-011418-hy8xmtiq 61 3 used use VBN cord-011418-hy8xmtiq 61 4 alone alone RB cord-011418-hy8xmtiq 61 5 or or CC cord-011418-hy8xmtiq 61 6 paired pair VBN cord-011418-hy8xmtiq 61 7 together together RB cord-011418-hy8xmtiq 61 8 with with IN cord-011418-hy8xmtiq 61 9 SBT SBT NNP cord-011418-hy8xmtiq 61 10 has have VBZ cord-011418-hy8xmtiq 61 11 been be VBN cord-011418-hy8xmtiq 61 12 shown show VBN cord-011418-hy8xmtiq 61 13 to to TO cord-011418-hy8xmtiq 61 14 lead lead VB cord-011418-hy8xmtiq 61 15 to to IN cord-011418-hy8xmtiq 61 16 earlier early JJR cord-011418-hy8xmtiq 61 17 discontinuation discontinuation NN cord-011418-hy8xmtiq 61 18 of of IN cord-011418-hy8xmtiq 61 19 mechanical mechanical JJ cord-011418-hy8xmtiq 61 20 ventilation ventilation NN cord-011418-hy8xmtiq 61 21 , , , cord-011418-hy8xmtiq 61 22 decreased decrease VBD cord-011418-hy8xmtiq 61 23 ICU ICU NNP cord-011418-hy8xmtiq 61 24 length length NN cord-011418-hy8xmtiq 61 25 of of IN cord-011418-hy8xmtiq 61 26 stay stay NN cord-011418-hy8xmtiq 61 27 , , , cord-011418-hy8xmtiq 61 28 and and CC cord-011418-hy8xmtiq 61 29 improved improve VBD cord-011418-hy8xmtiq 61 30 1-year 1-year CD cord-011418-hy8xmtiq 61 31 survival survival NN cord-011418-hy8xmtiq 61 32 in in IN cord-011418-hy8xmtiq 61 33 critically critically RB cord-011418-hy8xmtiq 61 34 ill ill JJ cord-011418-hy8xmtiq 61 35 adult adult NN cord-011418-hy8xmtiq 61 36 patients patient NNS cord-011418-hy8xmtiq 61 37 [ [ -LRB- cord-011418-hy8xmtiq 61 38 28• 28• CD cord-011418-hy8xmtiq 61 39 , , , cord-011418-hy8xmtiq 61 40 32 32 CD cord-011418-hy8xmtiq 61 41 ] ] -RRB- cord-011418-hy8xmtiq 61 42 . . . cord-011418-hy8xmtiq 62 1 Tips tip NNS cord-011418-hy8xmtiq 62 2 for for IN cord-011418-hy8xmtiq 62 3 Implementation implementation NN cord-011418-hy8xmtiq 62 4 Start Start NNP cord-011418-hy8xmtiq 62 5 by by IN cord-011418-hy8xmtiq 62 6 forming form VBG cord-011418-hy8xmtiq 62 7 a a DT cord-011418-hy8xmtiq 62 8 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 62 9 team team NN cord-011418-hy8xmtiq 62 10 of of IN cord-011418-hy8xmtiq 62 11 physicians physician NNS cord-011418-hy8xmtiq 62 12 , , , cord-011418-hy8xmtiq 62 13 respiratory respiratory JJ cord-011418-hy8xmtiq 62 14 therapists therapist NNS cord-011418-hy8xmtiq 62 15 ( ( -LRB- cord-011418-hy8xmtiq 62 16 RT RT NNP cord-011418-hy8xmtiq 62 17 ) ) -RRB- cord-011418-hy8xmtiq 62 18 , , , cord-011418-hy8xmtiq 62 19 and and CC cord-011418-hy8xmtiq 62 20 registered register VBN cord-011418-hy8xmtiq 62 21 nurses nurse NNS cord-011418-hy8xmtiq 62 22 ( ( -LRB- cord-011418-hy8xmtiq 62 23 RN rn NN cord-011418-hy8xmtiq 62 24 ) ) -RRB- cord-011418-hy8xmtiq 63 1 to to TO cord-011418-hy8xmtiq 63 2 agree agree VB cord-011418-hy8xmtiq 63 3 on on IN cord-011418-hy8xmtiq 63 4 selection selection NN cord-011418-hy8xmtiq 63 5 criteria criterion NNS cord-011418-hy8xmtiq 63 6 that that WDT cord-011418-hy8xmtiq 63 7 would would MD cord-011418-hy8xmtiq 63 8 allow allow VB cord-011418-hy8xmtiq 63 9 patients patient NNS cord-011418-hy8xmtiq 63 10 to to TO cord-011418-hy8xmtiq 63 11 begin begin VB cord-011418-hy8xmtiq 63 12 SBT SBT NNP cord-011418-hy8xmtiq 63 13 trials trial NNS cord-011418-hy8xmtiq 63 14 , , , cord-011418-hy8xmtiq 63 15 set set VBD cord-011418-hy8xmtiq 63 16 the the DT cord-011418-hy8xmtiq 63 17 criteria criterion NNS cord-011418-hy8xmtiq 63 18 that that WDT cord-011418-hy8xmtiq 63 19 determine determine VBP cord-011418-hy8xmtiq 63 20 trial trial NN cord-011418-hy8xmtiq 63 21 failure failure NN cord-011418-hy8xmtiq 63 22 , , , cord-011418-hy8xmtiq 63 23 and and CC cord-011418-hy8xmtiq 63 24 determine determine VB cord-011418-hy8xmtiq 63 25 what what WP cord-011418-hy8xmtiq 63 26 next next JJ cord-011418-hy8xmtiq 63 27 steps step NNS cord-011418-hy8xmtiq 63 28 will will MD cord-011418-hy8xmtiq 63 29 be be VB cord-011418-hy8xmtiq 63 30 for for IN cord-011418-hy8xmtiq 63 31 patients patient NNS cord-011418-hy8xmtiq 63 32 who who WP cord-011418-hy8xmtiq 63 33 have have VBP cord-011418-hy8xmtiq 63 34 passed pass VBN cord-011418-hy8xmtiq 63 35 the the DT cord-011418-hy8xmtiq 63 36 SBT SBT NNP cord-011418-hy8xmtiq 63 37 . . . cord-011418-hy8xmtiq 64 1 Once once RB cord-011418-hy8xmtiq 64 2 agreed agree VBN cord-011418-hy8xmtiq 64 3 upon upon IN cord-011418-hy8xmtiq 64 4 criteria criterion NNS cord-011418-hy8xmtiq 64 5 are be VBP cord-011418-hy8xmtiq 64 6 established establish VBN cord-011418-hy8xmtiq 64 7 , , , cord-011418-hy8xmtiq 64 8 trial trial NN cord-011418-hy8xmtiq 64 9 a a DT cord-011418-hy8xmtiq 64 10 huddle huddle NN cord-011418-hy8xmtiq 64 11 each each DT cord-011418-hy8xmtiq 64 12 morning morning NN cord-011418-hy8xmtiq 64 13 to to TO cord-011418-hy8xmtiq 64 14 discuss discuss VB cord-011418-hy8xmtiq 64 15 which which WDT cord-011418-hy8xmtiq 64 16 of of IN cord-011418-hy8xmtiq 64 17 the the DT cord-011418-hy8xmtiq 64 18 current current JJ cord-011418-hy8xmtiq 64 19 patients patient NNS cord-011418-hy8xmtiq 64 20 in in IN cord-011418-hy8xmtiq 64 21 the the DT cord-011418-hy8xmtiq 64 22 PICU PICU NNP cord-011418-hy8xmtiq 64 23 meet meet NNP cord-011418-hy8xmtiq 64 24 criteria criterion NNS cord-011418-hy8xmtiq 64 25 . . . cord-011418-hy8xmtiq 65 1 Be be VB cord-011418-hy8xmtiq 65 2 sure sure JJ cord-011418-hy8xmtiq 65 3 to to TO cord-011418-hy8xmtiq 65 4 coordinate coordinate VB cord-011418-hy8xmtiq 65 5 the the DT cord-011418-hy8xmtiq 65 6 SAT SAT NNP cord-011418-hy8xmtiq 65 7 / / SYM cord-011418-hy8xmtiq 65 8 SBT SBT NNP cord-011418-hy8xmtiq 65 9 trial trial NN cord-011418-hy8xmtiq 65 10 with with IN cord-011418-hy8xmtiq 65 11 RN RN NNP cord-011418-hy8xmtiq 65 12 / / SYM cord-011418-hy8xmtiq 65 13 RT rt NN cord-011418-hy8xmtiq 65 14 availability availability NN cord-011418-hy8xmtiq 65 15 . . . cord-011418-hy8xmtiq 66 1 Over over IN cord-011418-hy8xmtiq 66 2 time time NN cord-011418-hy8xmtiq 66 3 , , , cord-011418-hy8xmtiq 66 4 consider consider VB cord-011418-hy8xmtiq 66 5 tracking track VBG cord-011418-hy8xmtiq 66 6 the the DT cord-011418-hy8xmtiq 66 7 percentage percentage NN cord-011418-hy8xmtiq 66 8 of of IN cord-011418-hy8xmtiq 66 9 patients patient NNS cord-011418-hy8xmtiq 66 10 that that WDT cord-011418-hy8xmtiq 66 11 qualify qualify VBP cord-011418-hy8xmtiq 66 12 for for IN cord-011418-hy8xmtiq 66 13 SAT SAT NNP cord-011418-hy8xmtiq 66 14 / / SYM cord-011418-hy8xmtiq 66 15 SBT SBT NNP cord-011418-hy8xmtiq 66 16 who who WP cord-011418-hy8xmtiq 66 17 pass pass VBP cord-011418-hy8xmtiq 66 18 and and CC cord-011418-hy8xmtiq 66 19 are be VBP cord-011418-hy8xmtiq 66 20 able able JJ cord-011418-hy8xmtiq 66 21 to to TO cord-011418-hy8xmtiq 66 22 be be VB cord-011418-hy8xmtiq 66 23 successfully successfully RB cord-011418-hy8xmtiq 66 24 extubated extubate VBN cord-011418-hy8xmtiq 66 25 . . . cord-011418-hy8xmtiq 67 1 The the DT cord-011418-hy8xmtiq 67 2 use use NN cord-011418-hy8xmtiq 67 3 of of IN cord-011418-hy8xmtiq 67 4 deep deep JJ cord-011418-hy8xmtiq 67 5 sedation sedation NN cord-011418-hy8xmtiq 67 6 has have VBZ cord-011418-hy8xmtiq 67 7 been be VBN cord-011418-hy8xmtiq 67 8 shown show VBN cord-011418-hy8xmtiq 67 9 to to TO cord-011418-hy8xmtiq 67 10 be be VB cord-011418-hy8xmtiq 67 11 associated associate VBN cord-011418-hy8xmtiq 67 12 with with IN cord-011418-hy8xmtiq 67 13 worse bad JJR cord-011418-hy8xmtiq 67 14 short short JJ cord-011418-hy8xmtiq 67 15 - - HYPH cord-011418-hy8xmtiq 67 16 term term NN cord-011418-hy8xmtiq 67 17 and and CC cord-011418-hy8xmtiq 67 18 long long JJ cord-011418-hy8xmtiq 67 19 - - HYPH cord-011418-hy8xmtiq 67 20 term term NN cord-011418-hy8xmtiq 67 21 outcomes outcome NNS cord-011418-hy8xmtiq 67 22 [ [ -LRB- cord-011418-hy8xmtiq 67 23 31 31 CD cord-011418-hy8xmtiq 67 24 , , , cord-011418-hy8xmtiq 67 25 33 33 CD cord-011418-hy8xmtiq 67 26 ] ] -RRB- cord-011418-hy8xmtiq 67 27 . . . cord-011418-hy8xmtiq 68 1 Whenever whenever WRB cord-011418-hy8xmtiq 68 2 feasible feasible JJ cord-011418-hy8xmtiq 68 3 , , , cord-011418-hy8xmtiq 68 4 the the DT cord-011418-hy8xmtiq 68 5 goal goal NN cord-011418-hy8xmtiq 68 6 of of IN cord-011418-hy8xmtiq 68 7 sedation sedation NN cord-011418-hy8xmtiq 68 8 should should MD cord-011418-hy8xmtiq 68 9 be be VB cord-011418-hy8xmtiq 68 10 to to TO cord-011418-hy8xmtiq 68 11 have have VB cord-011418-hy8xmtiq 68 12 our -PRON- PRP$ cord-011418-hy8xmtiq 68 13 patients patient NNS cord-011418-hy8xmtiq 68 14 be be VB cord-011418-hy8xmtiq 68 15 as as RB cord-011418-hy8xmtiq 68 16 close close JJ cord-011418-hy8xmtiq 68 17 to to TO cord-011418-hy8xmtiq 68 18 alert alert VB cord-011418-hy8xmtiq 68 19 and and CC cord-011418-hy8xmtiq 68 20 calm calm JJ cord-011418-hy8xmtiq 68 21 as as RB cord-011418-hy8xmtiq 68 22 safely safely RB cord-011418-hy8xmtiq 68 23 possible possible JJ cord-011418-hy8xmtiq 68 24 . . . cord-011418-hy8xmtiq 69 1 Numerous numerous JJ cord-011418-hy8xmtiq 69 2 adult adult NN cord-011418-hy8xmtiq 69 3 studies study NNS cord-011418-hy8xmtiq 69 4 have have VBP cord-011418-hy8xmtiq 69 5 demonstrated demonstrate VBN cord-011418-hy8xmtiq 69 6 significant significant JJ cord-011418-hy8xmtiq 69 7 benefit benefit NN cord-011418-hy8xmtiq 69 8 in in IN cord-011418-hy8xmtiq 69 9 optimizing optimize VBG cord-011418-hy8xmtiq 69 10 pain pain NN cord-011418-hy8xmtiq 69 11 treatment treatment NN cord-011418-hy8xmtiq 69 12 in in IN cord-011418-hy8xmtiq 69 13 critically critically RB cord-011418-hy8xmtiq 69 14 ill ill JJ cord-011418-hy8xmtiq 69 15 patients patient NNS cord-011418-hy8xmtiq 69 16 versus versus IN cord-011418-hy8xmtiq 69 17 only only RB cord-011418-hy8xmtiq 69 18 providing provide VBG cord-011418-hy8xmtiq 69 19 sedatives sedative NNS cord-011418-hy8xmtiq 69 20 . . . cord-011418-hy8xmtiq 70 1 This this DT cord-011418-hy8xmtiq 70 2 practice practice NN cord-011418-hy8xmtiq 70 3 , , , cord-011418-hy8xmtiq 70 4 termed term VBD cord-011418-hy8xmtiq 70 5 " " `` cord-011418-hy8xmtiq 70 6 analgosedation analgosedation NN cord-011418-hy8xmtiq 70 7 , , , cord-011418-hy8xmtiq 70 8 " " '' cord-011418-hy8xmtiq 70 9 has have VBZ cord-011418-hy8xmtiq 70 10 been be VBN cord-011418-hy8xmtiq 70 11 shown show VBN cord-011418-hy8xmtiq 70 12 to to TO cord-011418-hy8xmtiq 70 13 decrease decrease VB cord-011418-hy8xmtiq 70 14 duration duration NN cord-011418-hy8xmtiq 70 15 of of IN cord-011418-hy8xmtiq 70 16 mechanical mechanical JJ cord-011418-hy8xmtiq 70 17 ventilation ventilation NN cord-011418-hy8xmtiq 70 18 and and CC cord-011418-hy8xmtiq 70 19 shorten shorten VB cord-011418-hy8xmtiq 70 20 ICU ICU NNP cord-011418-hy8xmtiq 70 21 length length NN cord-011418-hy8xmtiq 70 22 of of IN cord-011418-hy8xmtiq 70 23 stay stay NN cord-011418-hy8xmtiq 70 24 in in IN cord-011418-hy8xmtiq 70 25 adults adult NNS cord-011418-hy8xmtiq 70 26 [ [ -LRB- cord-011418-hy8xmtiq 70 27 34 34 CD cord-011418-hy8xmtiq 70 28 ] ] -RRB- cord-011418-hy8xmtiq 70 29 . . . cord-011418-hy8xmtiq 71 1 As as IN cord-011418-hy8xmtiq 71 2 new new JJ cord-011418-hy8xmtiq 71 3 drugs drug NNS cord-011418-hy8xmtiq 71 4 emerge emerge VBP cord-011418-hy8xmtiq 71 5 and and CC cord-011418-hy8xmtiq 71 6 we -PRON- PRP cord-011418-hy8xmtiq 71 7 continue continue VBP cord-011418-hy8xmtiq 71 8 to to TO cord-011418-hy8xmtiq 71 9 learn learn VB cord-011418-hy8xmtiq 71 10 about about IN cord-011418-hy8xmtiq 71 11 the the DT cord-011418-hy8xmtiq 71 12 detrimental detrimental JJ cord-011418-hy8xmtiq 71 13 effects effect NNS cord-011418-hy8xmtiq 71 14 of of IN cord-011418-hy8xmtiq 71 15 long long JJ cord-011418-hy8xmtiq 71 16 - - HYPH cord-011418-hy8xmtiq 71 17 term term NN cord-011418-hy8xmtiq 71 18 sedation sedation NN cord-011418-hy8xmtiq 71 19 and and CC cord-011418-hy8xmtiq 71 20 neuromuscular neuromuscular NN cord-011418-hy8xmtiq 71 21 blockade blockade NN cord-011418-hy8xmtiq 71 22 , , , cord-011418-hy8xmtiq 71 23 sedation sedation NN cord-011418-hy8xmtiq 71 24 and and CC cord-011418-hy8xmtiq 71 25 analgesia analgesia NN cord-011418-hy8xmtiq 71 26 for for IN cord-011418-hy8xmtiq 71 27 our -PRON- PRP$ cord-011418-hy8xmtiq 71 28 patients patient NNS cord-011418-hy8xmtiq 71 29 become become VBP cord-011418-hy8xmtiq 71 30 an an DT cord-011418-hy8xmtiq 71 31 increasingly increasingly RB cord-011418-hy8xmtiq 71 32 important important JJ cord-011418-hy8xmtiq 71 33 and and CC cord-011418-hy8xmtiq 71 34 complex complex JJ cord-011418-hy8xmtiq 71 35 choice choice NN cord-011418-hy8xmtiq 71 36 . . . cord-011418-hy8xmtiq 72 1 The the DT cord-011418-hy8xmtiq 72 2 first first JJ cord-011418-hy8xmtiq 72 3 choice choice NN cord-011418-hy8xmtiq 72 4 when when WRB cord-011418-hy8xmtiq 72 5 determining determine VBG cord-011418-hy8xmtiq 72 6 a a DT cord-011418-hy8xmtiq 72 7 sedative sedative JJ cord-011418-hy8xmtiq 72 8 and and CC cord-011418-hy8xmtiq 72 9 analgesic analgesic JJ cord-011418-hy8xmtiq 72 10 regimen regimen NN cord-011418-hy8xmtiq 72 11 for for IN cord-011418-hy8xmtiq 72 12 a a DT cord-011418-hy8xmtiq 72 13 critically critically RB cord-011418-hy8xmtiq 72 14 ill ill JJ cord-011418-hy8xmtiq 72 15 patient patient NN cord-011418-hy8xmtiq 72 16 is be VBZ cord-011418-hy8xmtiq 72 17 to to TO cord-011418-hy8xmtiq 72 18 choose choose VB cord-011418-hy8xmtiq 72 19 the the DT cord-011418-hy8xmtiq 72 20 degree degree NN cord-011418-hy8xmtiq 72 21 / / SYM cord-011418-hy8xmtiq 72 22 depth depth NN cord-011418-hy8xmtiq 72 23 of of IN cord-011418-hy8xmtiq 72 24 sedation sedation NN cord-011418-hy8xmtiq 72 25 targeted target VBN cord-011418-hy8xmtiq 72 26 . . . cord-011418-hy8xmtiq 73 1 The the DT cord-011418-hy8xmtiq 73 2 Richmond Richmond NNP cord-011418-hy8xmtiq 73 3 Agitation Agitation NNP cord-011418-hy8xmtiq 73 4 Sedation Sedation NNP cord-011418-hy8xmtiq 73 5 Scale scale NN cord-011418-hy8xmtiq 73 6 ( ( -LRB- cord-011418-hy8xmtiq 73 7 RASS RASS NNP cord-011418-hy8xmtiq 73 8 ) ) -RRB- cord-011418-hy8xmtiq 73 9 , , , cord-011418-hy8xmtiq 73 10 the the DT cord-011418-hy8xmtiq 73 11 State State NNP cord-011418-hy8xmtiq 73 12 Behavioral Behavioral NNP cord-011418-hy8xmtiq 73 13 Scale Scale NNP cord-011418-hy8xmtiq 73 14 ( ( -LRB- cord-011418-hy8xmtiq 73 15 SBS SBS NNP cord-011418-hy8xmtiq 73 16 ) ) -RRB- cord-011418-hy8xmtiq 73 17 , , , cord-011418-hy8xmtiq 73 18 and and CC cord-011418-hy8xmtiq 73 19 the the DT cord-011418-hy8xmtiq 73 20 COMFORT comfort NN cord-011418-hy8xmtiq 73 21 behavioral behavioral JJ cord-011418-hy8xmtiq 73 22 scale scale NN cord-011418-hy8xmtiq 73 23 ( ( -LRB- cord-011418-hy8xmtiq 73 24 COMFORT comfort NN cord-011418-hy8xmtiq 73 25 - - HYPH cord-011418-hy8xmtiq 73 26 B B NNP cord-011418-hy8xmtiq 73 27 ) ) -RRB- cord-011418-hy8xmtiq 73 28 are be VBP cord-011418-hy8xmtiq 73 29 validated validate VBN cord-011418-hy8xmtiq 73 30 sedation sedation NN cord-011418-hy8xmtiq 73 31 scales scale NNS cord-011418-hy8xmtiq 73 32 for for IN cord-011418-hy8xmtiq 73 33 use use NN cord-011418-hy8xmtiq 73 34 in in IN cord-011418-hy8xmtiq 73 35 pediatrics pediatric NNS cord-011418-hy8xmtiq 73 36 , , , cord-011418-hy8xmtiq 73 37 with with IN cord-011418-hy8xmtiq 73 38 the the DT cord-011418-hy8xmtiq 73 39 RASS RASS NNP cord-011418-hy8xmtiq 73 40 and and CC cord-011418-hy8xmtiq 73 41 the the DT cord-011418-hy8xmtiq 73 42 COMFORT COMFORT NNP cord-011418-hy8xmtiq 73 43 - - HYPH cord-011418-hy8xmtiq 73 44 B B NNP cord-011418-hy8xmtiq 73 45 having have VBG cord-011418-hy8xmtiq 73 46 the the DT cord-011418-hy8xmtiq 73 47 advantage advantage NN cord-011418-hy8xmtiq 73 48 of of IN cord-011418-hy8xmtiq 73 49 having have VBG cord-011418-hy8xmtiq 73 50 been be VBN cord-011418-hy8xmtiq 73 51 validated validate VBN cord-011418-hy8xmtiq 73 52 in in IN cord-011418-hy8xmtiq 73 53 both both CC cord-011418-hy8xmtiq 73 54 intubated intubate VBN cord-011418-hy8xmtiq 73 55 and and CC cord-011418-hy8xmtiq 73 56 non non JJ cord-011418-hy8xmtiq 73 57 - - JJ cord-011418-hy8xmtiq 73 58 intubated intubate VBN cord-011418-hy8xmtiq 73 59 patients patient NNS cord-011418-hy8xmtiq 73 60 [ [ -LRB- cord-011418-hy8xmtiq 73 61 35 35 CD cord-011418-hy8xmtiq 73 62 ] ] -RRB- cord-011418-hy8xmtiq 73 63 [ [ -LRB- cord-011418-hy8xmtiq 73 64 36 36 CD cord-011418-hy8xmtiq 73 65 ] ] -RRB- cord-011418-hy8xmtiq 73 66 [ [ -LRB- cord-011418-hy8xmtiq 73 67 37 37 CD cord-011418-hy8xmtiq 73 68 ] ] -RRB- cord-011418-hy8xmtiq 73 69 . . . cord-011418-hy8xmtiq 74 1 Once once IN cord-011418-hy8xmtiq 74 2 the the DT cord-011418-hy8xmtiq 74 3 depth depth NN cord-011418-hy8xmtiq 74 4 of of IN cord-011418-hy8xmtiq 74 5 sedation sedation NN cord-011418-hy8xmtiq 74 6 is be VBZ cord-011418-hy8xmtiq 74 7 chosen choose VBN cord-011418-hy8xmtiq 74 8 , , , cord-011418-hy8xmtiq 74 9 it -PRON- PRP cord-011418-hy8xmtiq 74 10 is be VBZ cord-011418-hy8xmtiq 74 11 important important JJ cord-011418-hy8xmtiq 74 12 to to TO cord-011418-hy8xmtiq 74 13 focus focus VB cord-011418-hy8xmtiq 74 14 on on IN cord-011418-hy8xmtiq 74 15 the the DT cord-011418-hy8xmtiq 74 16 selection selection NN cord-011418-hy8xmtiq 74 17 of of IN cord-011418-hy8xmtiq 74 18 specific specific JJ cord-011418-hy8xmtiq 74 19 sedative sedative JJ cord-011418-hy8xmtiq 74 20 and and CC cord-011418-hy8xmtiq 74 21 analgesic analgesic JJ cord-011418-hy8xmtiq 74 22 medications medication NNS cord-011418-hy8xmtiq 74 23 . . . cord-011418-hy8xmtiq 75 1 In in IN cord-011418-hy8xmtiq 75 2 the the DT cord-011418-hy8xmtiq 75 3 last last JJ cord-011418-hy8xmtiq 75 4 decade decade NN cord-011418-hy8xmtiq 75 5 , , , cord-011418-hy8xmtiq 75 6 an an DT cord-011418-hy8xmtiq 75 7 overwhelming overwhelming JJ cord-011418-hy8xmtiq 75 8 amount amount NN cord-011418-hy8xmtiq 75 9 of of IN cord-011418-hy8xmtiq 75 10 data datum NNS cord-011418-hy8xmtiq 75 11 has have VBZ cord-011418-hy8xmtiq 75 12 shown show VBN cord-011418-hy8xmtiq 75 13 that that IN cord-011418-hy8xmtiq 75 14 benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 75 15 are be VBP cord-011418-hy8xmtiq 75 16 independently independently RB cord-011418-hy8xmtiq 75 17 associated associate VBN cord-011418-hy8xmtiq 75 18 with with IN cord-011418-hy8xmtiq 75 19 the the DT cord-011418-hy8xmtiq 75 20 incidence incidence NN cord-011418-hy8xmtiq 75 21 of of IN cord-011418-hy8xmtiq 75 22 delirium delirium NN cord-011418-hy8xmtiq 75 23 [ [ -LRB- cord-011418-hy8xmtiq 75 24 38• 38• CD cord-011418-hy8xmtiq 75 25 , , , cord-011418-hy8xmtiq 75 26 39 39 CD cord-011418-hy8xmtiq 75 27 ] ] -RRB- cord-011418-hy8xmtiq 75 28 . . . cord-011418-hy8xmtiq 76 1 In in IN cord-011418-hy8xmtiq 76 2 light light NN cord-011418-hy8xmtiq 76 3 of of IN cord-011418-hy8xmtiq 76 4 this this DT cord-011418-hy8xmtiq 76 5 evidence evidence NN cord-011418-hy8xmtiq 76 6 , , , cord-011418-hy8xmtiq 76 7 benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 76 8 should should MD cord-011418-hy8xmtiq 76 9 not not RB cord-011418-hy8xmtiq 76 10 be be VB cord-011418-hy8xmtiq 76 11 used use VBN cord-011418-hy8xmtiq 76 12 as as IN cord-011418-hy8xmtiq 76 13 a a DT cord-011418-hy8xmtiq 76 14 first first JJ cord-011418-hy8xmtiq 76 15 - - HYPH cord-011418-hy8xmtiq 76 16 line line NN cord-011418-hy8xmtiq 76 17 sedative sedative NN cord-011418-hy8xmtiq 76 18 in in IN cord-011418-hy8xmtiq 76 19 critically critically RB cord-011418-hy8xmtiq 76 20 ill ill JJ cord-011418-hy8xmtiq 76 21 children child NNS cord-011418-hy8xmtiq 76 22 . . . cord-011418-hy8xmtiq 77 1 The the DT cord-011418-hy8xmtiq 77 2 use use NN cord-011418-hy8xmtiq 77 3 of of IN cord-011418-hy8xmtiq 77 4 dexmedetomidine dexmedetomidine NN cord-011418-hy8xmtiq 77 5 has have VBZ cord-011418-hy8xmtiq 77 6 increased increase VBN cord-011418-hy8xmtiq 77 7 in in IN cord-011418-hy8xmtiq 77 8 the the DT cord-011418-hy8xmtiq 77 9 PICU PICU NNP cord-011418-hy8xmtiq 77 10 over over IN cord-011418-hy8xmtiq 77 11 the the DT cord-011418-hy8xmtiq 77 12 last last JJ cord-011418-hy8xmtiq 77 13 decade decade NN cord-011418-hy8xmtiq 77 14 and and CC cord-011418-hy8xmtiq 77 15 may may MD cord-011418-hy8xmtiq 77 16 shorten shorten VB cord-011418-hy8xmtiq 77 17 length length NN cord-011418-hy8xmtiq 77 18 of of IN cord-011418-hy8xmtiq 77 19 mechanical mechanical JJ cord-011418-hy8xmtiq 77 20 ventilation ventilation NN cord-011418-hy8xmtiq 77 21 as as RB cord-011418-hy8xmtiq 77 22 well well RB cord-011418-hy8xmtiq 77 23 as as IN cord-011418-hy8xmtiq 77 24 lower low JJR cord-011418-hy8xmtiq 77 25 opioid opioid NN cord-011418-hy8xmtiq 77 26 requirements requirement NNS cord-011418-hy8xmtiq 77 27 and and CC cord-011418-hy8xmtiq 77 28 incidence incidence NN cord-011418-hy8xmtiq 77 29 of of IN cord-011418-hy8xmtiq 77 30 delirium delirium NN cord-011418-hy8xmtiq 77 31 [ [ -LRB- cord-011418-hy8xmtiq 77 32 40 40 CD cord-011418-hy8xmtiq 77 33 , , , cord-011418-hy8xmtiq 77 34 41 41 CD cord-011418-hy8xmtiq 77 35 ] ] -RRB- cord-011418-hy8xmtiq 77 36 . . . cord-011418-hy8xmtiq 78 1 One one CD cord-011418-hy8xmtiq 78 2 emerging emerge VBG cord-011418-hy8xmtiq 78 3 area area NN cord-011418-hy8xmtiq 78 4 of of IN cord-011418-hy8xmtiq 78 5 interest interest NN cord-011418-hy8xmtiq 78 6 in in IN cord-011418-hy8xmtiq 78 7 the the DT cord-011418-hy8xmtiq 78 8 last last JJ cord-011418-hy8xmtiq 78 9 decade decade NN cord-011418-hy8xmtiq 78 10 has have VBZ cord-011418-hy8xmtiq 78 11 been be VBN cord-011418-hy8xmtiq 78 12 the the DT cord-011418-hy8xmtiq 78 13 use use NN cord-011418-hy8xmtiq 78 14 of of IN cord-011418-hy8xmtiq 78 15 sedation sedation NN cord-011418-hy8xmtiq 78 16 protocols protocol NNS cord-011418-hy8xmtiq 78 17 . . . cord-011418-hy8xmtiq 79 1 The the DT cord-011418-hy8xmtiq 79 2 Randomized Randomized NNP cord-011418-hy8xmtiq 79 3 Evaluation Evaluation NNP cord-011418-hy8xmtiq 79 4 of of IN cord-011418-hy8xmtiq 79 5 Sedation Sedation NNP cord-011418-hy8xmtiq 79 6 Titration Titration NNP cord-011418-hy8xmtiq 79 7 for for IN cord-011418-hy8xmtiq 79 8 Respiratory respiratory JJ cord-011418-hy8xmtiq 79 9 Failure failure NN cord-011418-hy8xmtiq 79 10 ( ( -LRB- cord-011418-hy8xmtiq 79 11 RESTORE restore VB cord-011418-hy8xmtiq 79 12 ) ) -RRB- cord-011418-hy8xmtiq 79 13 trial trial NN cord-011418-hy8xmtiq 79 14 showed show VBD cord-011418-hy8xmtiq 79 15 that that IN cord-011418-hy8xmtiq 79 16 protocolized protocolized JJ cord-011418-hy8xmtiq 79 17 sedation sedation NN cord-011418-hy8xmtiq 79 18 was be VBD cord-011418-hy8xmtiq 79 19 feasible feasible JJ cord-011418-hy8xmtiq 79 20 and and CC cord-011418-hy8xmtiq 79 21 led lead VBD cord-011418-hy8xmtiq 79 22 to to IN cord-011418-hy8xmtiq 79 23 fewer few JJR cord-011418-hy8xmtiq 79 24 days day NNS cord-011418-hy8xmtiq 79 25 of of IN cord-011418-hy8xmtiq 79 26 opioid opioid JJ cord-011418-hy8xmtiq 79 27 administration administration NN cord-011418-hy8xmtiq 79 28 and and CC cord-011418-hy8xmtiq 79 29 exposure exposure NN cord-011418-hy8xmtiq 79 30 to to IN cord-011418-hy8xmtiq 79 31 fewer few JJR cord-011418-hy8xmtiq 79 32 sedative sedative JJ cord-011418-hy8xmtiq 79 33 classes class NNS cord-011418-hy8xmtiq 79 34 and and CC cord-011418-hy8xmtiq 79 35 that that IN cord-011418-hy8xmtiq 79 36 patients patient NNS cord-011418-hy8xmtiq 79 37 were be VBD cord-011418-hy8xmtiq 79 38 more more RBR cord-011418-hy8xmtiq 79 39 often often RB cord-011418-hy8xmtiq 79 40 awake awake JJ cord-011418-hy8xmtiq 79 41 and and CC cord-011418-hy8xmtiq 79 42 calm calm JJ cord-011418-hy8xmtiq 79 43 . . . cord-011418-hy8xmtiq 80 1 However however RB cord-011418-hy8xmtiq 80 2 , , , cord-011418-hy8xmtiq 80 3 protocolized protocolized JJ cord-011418-hy8xmtiq 80 4 sedation sedation NN cord-011418-hy8xmtiq 80 5 was be VBD cord-011418-hy8xmtiq 80 6 not not RB cord-011418-hy8xmtiq 80 7 found find VBN cord-011418-hy8xmtiq 80 8 to to TO cord-011418-hy8xmtiq 80 9 reduce reduce VB cord-011418-hy8xmtiq 80 10 the the DT cord-011418-hy8xmtiq 80 11 duration duration NN cord-011418-hy8xmtiq 80 12 of of IN cord-011418-hy8xmtiq 80 13 mechanical mechanical JJ cord-011418-hy8xmtiq 80 14 ventilation ventilation NN cord-011418-hy8xmtiq 80 15 and and CC cord-011418-hy8xmtiq 80 16 did do VBD cord-011418-hy8xmtiq 80 17 increase increase VB cord-011418-hy8xmtiq 80 18 days day NNS cord-011418-hy8xmtiq 80 19 with with IN cord-011418-hy8xmtiq 80 20 any any DT cord-011418-hy8xmtiq 80 21 report report NN cord-011418-hy8xmtiq 80 22 of of IN cord-011418-hy8xmtiq 80 23 pain pain NN cord-011418-hy8xmtiq 80 24 and and CC cord-011418-hy8xmtiq 80 25 agitation agitation NN cord-011418-hy8xmtiq 80 26 [ [ -LRB- cord-011418-hy8xmtiq 80 27 42 42 CD cord-011418-hy8xmtiq 80 28 ] ] -RRB- cord-011418-hy8xmtiq 80 29 . . . cord-011418-hy8xmtiq 81 1 Subsequent subsequent JJ cord-011418-hy8xmtiq 81 2 studies study NNS cord-011418-hy8xmtiq 81 3 of of IN cord-011418-hy8xmtiq 81 4 nurse nurse NN cord-011418-hy8xmtiq 81 5 - - HYPH cord-011418-hy8xmtiq 81 6 driven drive VBN cord-011418-hy8xmtiq 81 7 sedation sedation NN cord-011418-hy8xmtiq 81 8 protocols protocol NNS cord-011418-hy8xmtiq 81 9 have have VBP cord-011418-hy8xmtiq 81 10 continued continue VBN cord-011418-hy8xmtiq 81 11 to to TO cord-011418-hy8xmtiq 81 12 show show VB cord-011418-hy8xmtiq 81 13 its -PRON- PRP$ cord-011418-hy8xmtiq 81 14 safety safety NN cord-011418-hy8xmtiq 81 15 and and CC cord-011418-hy8xmtiq 81 16 efficacy efficacy NN cord-011418-hy8xmtiq 81 17 , , , cord-011418-hy8xmtiq 81 18 as as RB cord-011418-hy8xmtiq 81 19 well well RB cord-011418-hy8xmtiq 81 20 as as IN cord-011418-hy8xmtiq 81 21 its -PRON- PRP$ cord-011418-hy8xmtiq 81 22 ability ability NN cord-011418-hy8xmtiq 81 23 to to TO cord-011418-hy8xmtiq 81 24 reduce reduce VB cord-011418-hy8xmtiq 81 25 benzodiazepine benzodiazepine NN cord-011418-hy8xmtiq 81 26 administration administration NN cord-011418-hy8xmtiq 81 27 , , , cord-011418-hy8xmtiq 81 28 shorten shorten VB cord-011418-hy8xmtiq 81 29 duration duration NN cord-011418-hy8xmtiq 81 30 of of IN cord-011418-hy8xmtiq 81 31 mechanical mechanical JJ cord-011418-hy8xmtiq 81 32 ventilation ventilation NN cord-011418-hy8xmtiq 81 33 , , , cord-011418-hy8xmtiq 81 34 and and CC cord-011418-hy8xmtiq 81 35 decrease decrease VB cord-011418-hy8xmtiq 81 36 the the DT cord-011418-hy8xmtiq 81 37 occurrence occurrence NN cord-011418-hy8xmtiq 81 38 of of IN cord-011418-hy8xmtiq 81 39 withdrawal withdrawal NN cord-011418-hy8xmtiq 81 40 symptoms symptom NNS cord-011418-hy8xmtiq 81 41 [ [ -LRB- cord-011418-hy8xmtiq 81 42 43 43 CD cord-011418-hy8xmtiq 81 43 , , , cord-011418-hy8xmtiq 81 44 44 44 CD cord-011418-hy8xmtiq 81 45 ] ] -RRB- cord-011418-hy8xmtiq 81 46 . . . cord-011418-hy8xmtiq 82 1 Tips tip NNS cord-011418-hy8xmtiq 82 2 for for IN cord-011418-hy8xmtiq 82 3 Implementation implementation NN cord-011418-hy8xmtiq 82 4 Start Start NNP cord-011418-hy8xmtiq 82 5 by by IN cord-011418-hy8xmtiq 82 6 incorporating incorporate VBG cord-011418-hy8xmtiq 82 7 a a DT cord-011418-hy8xmtiq 82 8 validated validate VBN cord-011418-hy8xmtiq 82 9 tool tool NN cord-011418-hy8xmtiq 82 10 for for IN cord-011418-hy8xmtiq 82 11 sedation sedation NN cord-011418-hy8xmtiq 82 12 in in IN cord-011418-hy8xmtiq 82 13 the the DT cord-011418-hy8xmtiq 82 14 nursing nursing NN cord-011418-hy8xmtiq 82 15 assessment assessment NN cord-011418-hy8xmtiq 82 16 and and CC cord-011418-hy8xmtiq 82 17 educate educate VB cord-011418-hy8xmtiq 82 18 key key JJ cord-011418-hy8xmtiq 82 19 stakeholders stakeholder NNS cord-011418-hy8xmtiq 82 20 ( ( -LRB- cord-011418-hy8xmtiq 82 21 nursing nursing NN cord-011418-hy8xmtiq 82 22 , , , cord-011418-hy8xmtiq 82 23 residents resident NNS cord-011418-hy8xmtiq 82 24 / / SYM cord-011418-hy8xmtiq 82 25 fellows fellow NNS cord-011418-hy8xmtiq 82 26 ) ) -RRB- cord-011418-hy8xmtiq 82 27 on on IN cord-011418-hy8xmtiq 82 28 the the DT cord-011418-hy8xmtiq 82 29 benefit benefit NN cord-011418-hy8xmtiq 82 30 of of IN cord-011418-hy8xmtiq 82 31 analgosedation analgosedation NN cord-011418-hy8xmtiq 82 32 . . . cord-011418-hy8xmtiq 83 1 Incorporate incorporate VB cord-011418-hy8xmtiq 83 2 and and CC cord-011418-hy8xmtiq 83 3 discuss discuss VB cord-011418-hy8xmtiq 83 4 sedation sedation NN cord-011418-hy8xmtiq 83 5 targets/ targets/ CD cord-011418-hy8xmtiq 83 6 goals goal NNS cord-011418-hy8xmtiq 83 7 at at IN cord-011418-hy8xmtiq 83 8 least least JJS cord-011418-hy8xmtiq 83 9 daily daily RB cord-011418-hy8xmtiq 83 10 on on IN cord-011418-hy8xmtiq 83 11 rounds round NNS cord-011418-hy8xmtiq 83 12 . . . cord-011418-hy8xmtiq 84 1 Form form VB cord-011418-hy8xmtiq 84 2 a a DT cord-011418-hy8xmtiq 84 3 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 84 4 team team NN cord-011418-hy8xmtiq 84 5 to to TO cord-011418-hy8xmtiq 84 6 develop develop VB cord-011418-hy8xmtiq 84 7 and and CC cord-011418-hy8xmtiq 84 8 implement implement VB cord-011418-hy8xmtiq 84 9 a a DT cord-011418-hy8xmtiq 84 10 sedation sedation NN cord-011418-hy8xmtiq 84 11 protocol protocol NN cord-011418-hy8xmtiq 84 12 ; ; : cord-011418-hy8xmtiq 84 13 addressing address VBG cord-011418-hy8xmtiq 84 14 analgesia analgesia NN cord-011418-hy8xmtiq 84 15 first first RB cord-011418-hy8xmtiq 84 16 and and CC cord-011418-hy8xmtiq 84 17 avoiding avoid VBG cord-011418-hy8xmtiq 84 18 benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 84 19 are be VBP cord-011418-hy8xmtiq 84 20 the the DT cord-011418-hy8xmtiq 84 21 first first JJ cord-011418-hy8xmtiq 84 22 - - HYPH cord-011418-hy8xmtiq 84 23 line line NN cord-011418-hy8xmtiq 84 24 choice choice NN cord-011418-hy8xmtiq 84 25 of of IN cord-011418-hy8xmtiq 84 26 sedative sedative NN cord-011418-hy8xmtiq 84 27 . . . cord-011418-hy8xmtiq 85 1 Delirium delirium NN cord-011418-hy8xmtiq 85 2 is be VBZ cord-011418-hy8xmtiq 85 3 a a DT cord-011418-hy8xmtiq 85 4 prevalent prevalent JJ cord-011418-hy8xmtiq 85 5 and and CC cord-011418-hy8xmtiq 85 6 serious serious JJ cord-011418-hy8xmtiq 85 7 complication complication NN cord-011418-hy8xmtiq 85 8 of of IN cord-011418-hy8xmtiq 85 9 critical critical JJ cord-011418-hy8xmtiq 85 10 illness illness NN cord-011418-hy8xmtiq 85 11 . . . cord-011418-hy8xmtiq 86 1 This this DT cord-011418-hy8xmtiq 86 2 complication complication NN cord-011418-hy8xmtiq 86 3 affects affect VBZ cord-011418-hy8xmtiq 86 4 25 25 CD cord-011418-hy8xmtiq 86 5 - - SYM cord-011418-hy8xmtiq 86 6 47 47 CD cord-011418-hy8xmtiq 86 7 % % NN cord-011418-hy8xmtiq 86 8 of of IN cord-011418-hy8xmtiq 86 9 critically critically RB cord-011418-hy8xmtiq 86 10 ill ill JJ cord-011418-hy8xmtiq 86 11 children child NNS cord-011418-hy8xmtiq 86 12 in in IN cord-011418-hy8xmtiq 86 13 the the DT cord-011418-hy8xmtiq 86 14 PICU PICU NNP cord-011418-hy8xmtiq 86 15 [ [ -LRB- cord-011418-hy8xmtiq 86 16 45• 45• CD cord-011418-hy8xmtiq 86 17 , , , cord-011418-hy8xmtiq 86 18 46 46 CD cord-011418-hy8xmtiq 86 19 , , , cord-011418-hy8xmtiq 86 20 47 47 CD cord-011418-hy8xmtiq 86 21 ] ] -RRB- cord-011418-hy8xmtiq 86 22 , , , cord-011418-hy8xmtiq 86 23 with with IN cord-011418-hy8xmtiq 86 24 an an DT cord-011418-hy8xmtiq 86 25 even even RB cord-011418-hy8xmtiq 86 26 higher high JJR cord-011418-hy8xmtiq 86 27 prevalence prevalence NN cord-011418-hy8xmtiq 86 28 in in IN cord-011418-hy8xmtiq 86 29 children child NNS cord-011418-hy8xmtiq 86 30 following follow VBG cord-011418-hy8xmtiq 86 31 cardiac cardiac JJ cord-011418-hy8xmtiq 86 32 surgery surgery NN cord-011418-hy8xmtiq 86 33 and and CC cord-011418-hy8xmtiq 86 34 cardiopulmonary cardiopulmonary JJ cord-011418-hy8xmtiq 86 35 bypass bypass NN cord-011418-hy8xmtiq 86 36 [ [ -LRB- cord-011418-hy8xmtiq 86 37 48 48 CD cord-011418-hy8xmtiq 86 38 , , , cord-011418-hy8xmtiq 86 39 49 49 CD cord-011418-hy8xmtiq 86 40 ] ] -RRB- cord-011418-hy8xmtiq 86 41 and and CC cord-011418-hy8xmtiq 86 42 in in IN cord-011418-hy8xmtiq 86 43 children child NNS cord-011418-hy8xmtiq 86 44 requiring require VBG cord-011418-hy8xmtiq 86 45 extracorporeal extracorporeal JJ cord-011418-hy8xmtiq 86 46 membrane membrane NN cord-011418-hy8xmtiq 86 47 oxygenation oxygenation NN cord-011418-hy8xmtiq 86 48 support support NN cord-011418-hy8xmtiq 86 49 [ [ -LRB- cord-011418-hy8xmtiq 86 50 50 50 CD cord-011418-hy8xmtiq 86 51 ] ] -RRB- cord-011418-hy8xmtiq 86 52 . . . cord-011418-hy8xmtiq 87 1 The the DT cord-011418-hy8xmtiq 87 2 development development NN cord-011418-hy8xmtiq 87 3 of of IN cord-011418-hy8xmtiq 87 4 delirium delirium NN cord-011418-hy8xmtiq 87 5 in in IN cord-011418-hy8xmtiq 87 6 critically critically RB cord-011418-hy8xmtiq 87 7 ill ill JJ cord-011418-hy8xmtiq 87 8 children child NNS cord-011418-hy8xmtiq 87 9 has have VBZ cord-011418-hy8xmtiq 87 10 been be VBN cord-011418-hy8xmtiq 87 11 shown show VBN cord-011418-hy8xmtiq 87 12 to to TO cord-011418-hy8xmtiq 87 13 be be VB cord-011418-hy8xmtiq 87 14 associated associate VBN cord-011418-hy8xmtiq 87 15 with with IN cord-011418-hy8xmtiq 87 16 increased increase VBN cord-011418-hy8xmtiq 87 17 morbidity morbidity NN cord-011418-hy8xmtiq 87 18 and and CC cord-011418-hy8xmtiq 87 19 mortality mortality NN cord-011418-hy8xmtiq 87 20 , , , cord-011418-hy8xmtiq 87 21 longer long JJR cord-011418-hy8xmtiq 87 22 duration duration NN cord-011418-hy8xmtiq 87 23 of of IN cord-011418-hy8xmtiq 87 24 mechanical mechanical JJ cord-011418-hy8xmtiq 87 25 ventilation ventilation NN cord-011418-hy8xmtiq 87 26 , , , cord-011418-hy8xmtiq 87 27 increased increase VBN cord-011418-hy8xmtiq 87 28 length length NN cord-011418-hy8xmtiq 87 29 of of IN cord-011418-hy8xmtiq 87 30 stay stay NN cord-011418-hy8xmtiq 87 31 , , , cord-011418-hy8xmtiq 87 32 as as RB cord-011418-hy8xmtiq 87 33 well well RB cord-011418-hy8xmtiq 87 34 as as IN cord-011418-hy8xmtiq 87 35 higher high JJR cord-011418-hy8xmtiq 87 36 resource resource NN cord-011418-hy8xmtiq 87 37 utilization utilization NN cord-011418-hy8xmtiq 87 38 and and CC cord-011418-hy8xmtiq 87 39 medical medical JJ cord-011418-hy8xmtiq 87 40 cost cost NN cord-011418-hy8xmtiq 87 41 [ [ -LRB- cord-011418-hy8xmtiq 87 42 51 51 CD cord-011418-hy8xmtiq 87 43 ] ] -RRB- cord-011418-hy8xmtiq 87 44 [ [ -LRB- cord-011418-hy8xmtiq 87 45 52 52 CD cord-011418-hy8xmtiq 87 46 ] ] -RRB- cord-011418-hy8xmtiq 87 47 [ [ -LRB- cord-011418-hy8xmtiq 87 48 53 53 CD cord-011418-hy8xmtiq 87 49 ] ] -RRB- cord-011418-hy8xmtiq 87 50 . . . cord-011418-hy8xmtiq 88 1 There there EX cord-011418-hy8xmtiq 88 2 are be VBP cord-011418-hy8xmtiq 88 3 three three CD cord-011418-hy8xmtiq 88 4 motoric motoric JJ cord-011418-hy8xmtiq 88 5 subtypes subtype NNS cord-011418-hy8xmtiq 88 6 of of IN cord-011418-hy8xmtiq 88 7 delirium delirium NN cord-011418-hy8xmtiq 88 8 : : : cord-011418-hy8xmtiq 88 9 hyperactive hyperactive JJ cord-011418-hy8xmtiq 88 10 , , , cord-011418-hy8xmtiq 88 11 hypoactive hypoactive JJ cord-011418-hy8xmtiq 88 12 , , , cord-011418-hy8xmtiq 88 13 and and CC cord-011418-hy8xmtiq 88 14 mixed mixed JJ cord-011418-hy8xmtiq 88 15 - - HYPH cord-011418-hy8xmtiq 88 16 type type NN cord-011418-hy8xmtiq 88 17 delirium delirium NN cord-011418-hy8xmtiq 88 18 . . . cord-011418-hy8xmtiq 89 1 In in IN cord-011418-hy8xmtiq 89 2 critically critically RB cord-011418-hy8xmtiq 89 3 ill ill JJ cord-011418-hy8xmtiq 89 4 children child NNS cord-011418-hy8xmtiq 89 5 , , , cord-011418-hy8xmtiq 89 6 the the DT cord-011418-hy8xmtiq 89 7 hypoactive hypoactive JJ cord-011418-hy8xmtiq 89 8 subtype subtype NN cord-011418-hy8xmtiq 89 9 is be VBZ cord-011418-hy8xmtiq 89 10 by by IN cord-011418-hy8xmtiq 89 11 far far RB cord-011418-hy8xmtiq 89 12 the the DT cord-011418-hy8xmtiq 89 13 most most RBS cord-011418-hy8xmtiq 89 14 common common JJ cord-011418-hy8xmtiq 89 15 . . . cord-011418-hy8xmtiq 90 1 Hypoactive hypoactive JJ cord-011418-hy8xmtiq 90 2 delirium delirium NN cord-011418-hy8xmtiq 90 3 is be VBZ cord-011418-hy8xmtiq 90 4 characterized characterize VBN cord-011418-hy8xmtiq 90 5 by by IN cord-011418-hy8xmtiq 90 6 inattention inattention NN cord-011418-hy8xmtiq 90 7 , , , cord-011418-hy8xmtiq 90 8 decreased decrease VBD cord-011418-hy8xmtiq 90 9 responsiveness responsiveness NN cord-011418-hy8xmtiq 90 10 , , , cord-011418-hy8xmtiq 90 11 and and CC cord-011418-hy8xmtiq 90 12 lethargy lethargy NN cord-011418-hy8xmtiq 90 13 , , , cord-011418-hy8xmtiq 90 14 and and CC cord-011418-hy8xmtiq 90 15 without without IN cord-011418-hy8xmtiq 90 16 standardized standardized JJ cord-011418-hy8xmtiq 90 17 use use NN cord-011418-hy8xmtiq 90 18 of of IN cord-011418-hy8xmtiq 90 19 validated validated JJ cord-011418-hy8xmtiq 90 20 pediatric pediatric JJ cord-011418-hy8xmtiq 90 21 delirium delirium NN cord-011418-hy8xmtiq 90 22 screening screening NN cord-011418-hy8xmtiq 90 23 tools tool NNS cord-011418-hy8xmtiq 90 24 is be VBZ cord-011418-hy8xmtiq 90 25 the the DT cord-011418-hy8xmtiq 90 26 most most RBS cord-011418-hy8xmtiq 90 27 likely likely JJ cord-011418-hy8xmtiq 90 28 to to TO cord-011418-hy8xmtiq 90 29 be be VB cord-011418-hy8xmtiq 90 30 missed miss VBN cord-011418-hy8xmtiq 90 31 or or CC cord-011418-hy8xmtiq 90 32 misdiagnosed misdiagnose VBN cord-011418-hy8xmtiq 90 33 as as IN cord-011418-hy8xmtiq 90 34 oversedation oversedation NN cord-011418-hy8xmtiq 90 35 . . . cord-011418-hy8xmtiq 91 1 There there EX cord-011418-hy8xmtiq 91 2 are be VBP cord-011418-hy8xmtiq 91 3 three three CD cord-011418-hy8xmtiq 91 4 validated validate VBN cord-011418-hy8xmtiq 91 5 screening screening NN cord-011418-hy8xmtiq 91 6 tools tool NNS cord-011418-hy8xmtiq 91 7 for for IN cord-011418-hy8xmtiq 91 8 use use NN cord-011418-hy8xmtiq 91 9 in in IN cord-011418-hy8xmtiq 91 10 critically critically RB cord-011418-hy8xmtiq 91 11 ill ill JJ cord-011418-hy8xmtiq 91 12 children child NNS cord-011418-hy8xmtiq 91 13 : : : cord-011418-hy8xmtiq 91 14 the the DT cord-011418-hy8xmtiq 91 15 Pediatric Pediatric NNP cord-011418-hy8xmtiq 91 16 Confusion Confusion NNP cord-011418-hy8xmtiq 91 17 Assessment Assessment NNP cord-011418-hy8xmtiq 91 18 Method Method NNP cord-011418-hy8xmtiq 91 19 for for IN cord-011418-hy8xmtiq 91 20 the the DT cord-011418-hy8xmtiq 91 21 Intensive Intensive NNP cord-011418-hy8xmtiq 91 22 Care Care NNP cord-011418-hy8xmtiq 91 23 Unit Unit NNP cord-011418-hy8xmtiq 91 24 ( ( -LRB- cord-011418-hy8xmtiq 91 25 pCAM pcam JJ cord-011418-hy8xmtiq 91 26 - - HYPH cord-011418-hy8xmtiq 91 27 ICU ICU NNP cord-011418-hy8xmtiq 91 28 ) ) -RRB- cord-011418-hy8xmtiq 91 29 and and CC cord-011418-hy8xmtiq 91 30 the the DT cord-011418-hy8xmtiq 91 31 Preschool Preschool NNP cord-011418-hy8xmtiq 91 32 Confusion Confusion NNP cord-011418-hy8xmtiq 91 33 Assessment Assessment NNP cord-011418-hy8xmtiq 91 34 Method Method NNP cord-011418-hy8xmtiq 91 35 for for IN cord-011418-hy8xmtiq 91 36 the the DT cord-011418-hy8xmtiq 91 37 ICU ICU NNP cord-011418-hy8xmtiq 91 38 ( ( -LRB- cord-011418-hy8xmtiq 91 39 psCAM psCAM NNP cord-011418-hy8xmtiq 91 40 - - HYPH cord-011418-hy8xmtiq 91 41 ICU ICU NNP cord-011418-hy8xmtiq 91 42 ) ) -RRB- cord-011418-hy8xmtiq 91 43 , , , cord-011418-hy8xmtiq 91 44 the the DT cord-011418-hy8xmtiq 91 45 Cornell Cornell NNP cord-011418-hy8xmtiq 91 46 Assessment Assessment NNP cord-011418-hy8xmtiq 91 47 of of IN cord-011418-hy8xmtiq 91 48 Pediatric Pediatric NNP cord-011418-hy8xmtiq 91 49 Delirium Delirium NNP cord-011418-hy8xmtiq 91 50 ( ( -LRB- cord-011418-hy8xmtiq 91 51 CAPD CAPD NNP cord-011418-hy8xmtiq 91 52 ) ) -RRB- cord-011418-hy8xmtiq 91 53 , , , cord-011418-hy8xmtiq 91 54 and and CC cord-011418-hy8xmtiq 91 55 the the DT cord-011418-hy8xmtiq 91 56 Sophia Sophia NNP cord-011418-hy8xmtiq 91 57 Observation Observation NNP cord-011418-hy8xmtiq 91 58 Withdrawal Withdrawal NNP cord-011418-hy8xmtiq 91 59 Symptoms Symptoms NNP cord-011418-hy8xmtiq 91 60 - - : cord-011418-hy8xmtiq 91 61 Pediatric Pediatric NNP cord-011418-hy8xmtiq 91 62 Delirium Delirium NNP cord-011418-hy8xmtiq 91 63 ( ( -LRB- cord-011418-hy8xmtiq 91 64 SOS SOS NNP cord-011418-hy8xmtiq 91 65 - - HYPH cord-011418-hy8xmtiq 91 66 PD PD NNP cord-011418-hy8xmtiq 91 67 ) ) -RRB- cord-011418-hy8xmtiq 91 68 scale scale NN cord-011418-hy8xmtiq 91 69 [ [ -LRB- cord-011418-hy8xmtiq 91 70 46 46 CD cord-011418-hy8xmtiq 91 71 , , , cord-011418-hy8xmtiq 91 72 47 47 CD cord-011418-hy8xmtiq 91 73 , , , cord-011418-hy8xmtiq 91 74 54 54 CD cord-011418-hy8xmtiq 91 75 , , , cord-011418-hy8xmtiq 91 76 55 55 CD cord-011418-hy8xmtiq 91 77 ] ] -RRB- cord-011418-hy8xmtiq 91 78 . . . cord-011418-hy8xmtiq 92 1 The the DT cord-011418-hy8xmtiq 92 2 use use NN cord-011418-hy8xmtiq 92 3 of of IN cord-011418-hy8xmtiq 92 4 these these DT cord-011418-hy8xmtiq 92 5 screening screening NN cord-011418-hy8xmtiq 92 6 tools tool NNS cord-011418-hy8xmtiq 92 7 is be VBZ cord-011418-hy8xmtiq 92 8 paramount paramount NN cord-011418-hy8xmtiq 92 9 to to IN cord-011418-hy8xmtiq 92 10 the the DT cord-011418-hy8xmtiq 92 11 assessment assessment NN cord-011418-hy8xmtiq 92 12 and and CC cord-011418-hy8xmtiq 92 13 diagnosis diagnosis NN cord-011418-hy8xmtiq 92 14 of of IN cord-011418-hy8xmtiq 92 15 delirium delirium NN cord-011418-hy8xmtiq 92 16 in in IN cord-011418-hy8xmtiq 92 17 critically critically RB cord-011418-hy8xmtiq 92 18 ill ill JJ cord-011418-hy8xmtiq 92 19 children child NNS cord-011418-hy8xmtiq 92 20 . . . cord-011418-hy8xmtiq 93 1 In in IN cord-011418-hy8xmtiq 93 2 the the DT cord-011418-hy8xmtiq 93 3 last last JJ cord-011418-hy8xmtiq 93 4 decade decade NN cord-011418-hy8xmtiq 93 5 , , , cord-011418-hy8xmtiq 93 6 modifiable modifiable JJ cord-011418-hy8xmtiq 93 7 and and CC cord-011418-hy8xmtiq 93 8 nonmodifiable nonmodifiable JJ cord-011418-hy8xmtiq 93 9 risk risk NN cord-011418-hy8xmtiq 93 10 factors factor NNS cord-011418-hy8xmtiq 93 11 for for IN cord-011418-hy8xmtiq 93 12 the the DT cord-011418-hy8xmtiq 93 13 development development NN cord-011418-hy8xmtiq 93 14 of of IN cord-011418-hy8xmtiq 93 15 pediatric pediatric JJ cord-011418-hy8xmtiq 93 16 delirium delirium NN cord-011418-hy8xmtiq 93 17 have have VBP cord-011418-hy8xmtiq 93 18 been be VBN cord-011418-hy8xmtiq 93 19 identified identify VBN cord-011418-hy8xmtiq 93 20 . . . cord-011418-hy8xmtiq 94 1 Younger young JJR cord-011418-hy8xmtiq 94 2 children child NNS cord-011418-hy8xmtiq 94 3 , , , cord-011418-hy8xmtiq 94 4 especially especially RB cord-011418-hy8xmtiq 94 5 under under IN cord-011418-hy8xmtiq 94 6 the the DT cord-011418-hy8xmtiq 94 7 age age NN cord-011418-hy8xmtiq 94 8 of of IN cord-011418-hy8xmtiq 94 9 2 2 CD cord-011418-hy8xmtiq 94 10 , , , cord-011418-hy8xmtiq 94 11 are be VBP cord-011418-hy8xmtiq 94 12 at at IN cord-011418-hy8xmtiq 94 13 higher high JJR cord-011418-hy8xmtiq 94 14 risk risk NN cord-011418-hy8xmtiq 94 15 of of IN cord-011418-hy8xmtiq 94 16 delirium delirium NN cord-011418-hy8xmtiq 94 17 , , , cord-011418-hy8xmtiq 94 18 as as IN cord-011418-hy8xmtiq 94 19 are be VBP cord-011418-hy8xmtiq 94 20 children child NNS cord-011418-hy8xmtiq 94 21 with with IN cord-011418-hy8xmtiq 94 22 underlying underlie VBG cord-011418-hy8xmtiq 94 23 developmental developmental JJ cord-011418-hy8xmtiq 94 24 delay delay NN cord-011418-hy8xmtiq 94 25 , , , cord-011418-hy8xmtiq 94 26 preexisting preexisting JJ cord-011418-hy8xmtiq 94 27 conditions condition NNS cord-011418-hy8xmtiq 94 28 , , , cord-011418-hy8xmtiq 94 29 and and CC cord-011418-hy8xmtiq 94 30 higher high JJR cord-011418-hy8xmtiq 94 31 severity severity NN cord-011418-hy8xmtiq 94 32 of of IN cord-011418-hy8xmtiq 94 33 illness illness NN cord-011418-hy8xmtiq 94 34 at at IN cord-011418-hy8xmtiq 94 35 PICU PICU NNP cord-011418-hy8xmtiq 94 36 admission admission NN cord-011418-hy8xmtiq 94 37 [ [ -LRB- cord-011418-hy8xmtiq 94 38 45• 45• CD cord-011418-hy8xmtiq 94 39 , , , cord-011418-hy8xmtiq 94 40 46 46 CD cord-011418-hy8xmtiq 94 41 , , , cord-011418-hy8xmtiq 94 42 47 47 CD cord-011418-hy8xmtiq 94 43 ] ] -RRB- cord-011418-hy8xmtiq 94 44 . . . cord-011418-hy8xmtiq 95 1 The the DT cord-011418-hy8xmtiq 95 2 use use NN cord-011418-hy8xmtiq 95 3 of of IN cord-011418-hy8xmtiq 95 4 benzodiazepine benzodiazepine NN cord-011418-hy8xmtiq 95 5 has have VBZ cord-011418-hy8xmtiq 95 6 been be VBN cord-011418-hy8xmtiq 95 7 shown show VBN cord-011418-hy8xmtiq 95 8 to to TO cord-011418-hy8xmtiq 95 9 be be VB cord-011418-hy8xmtiq 95 10 an an DT cord-011418-hy8xmtiq 95 11 independent independent JJ cord-011418-hy8xmtiq 95 12 risk risk NN cord-011418-hy8xmtiq 95 13 factor factor NN cord-011418-hy8xmtiq 95 14 for for IN cord-011418-hy8xmtiq 95 15 the the DT cord-011418-hy8xmtiq 95 16 development development NN cord-011418-hy8xmtiq 95 17 of of IN cord-011418-hy8xmtiq 95 18 delirium delirium NN cord-011418-hy8xmtiq 95 19 , , , cord-011418-hy8xmtiq 95 20 with with IN cord-011418-hy8xmtiq 95 21 a a DT cord-011418-hy8xmtiq 95 22 dose dose JJ cord-011418-hy8xmtiq 95 23 - - HYPH cord-011418-hy8xmtiq 95 24 response response NN cord-011418-hy8xmtiq 95 25 effect effect NN cord-011418-hy8xmtiq 95 26 [ [ -LRB- cord-011418-hy8xmtiq 95 27 38 38 CD cord-011418-hy8xmtiq 95 28 , , , cord-011418-hy8xmtiq 95 29 53 53 CD cord-011418-hy8xmtiq 95 30 , , , cord-011418-hy8xmtiq 95 31 56 56 CD cord-011418-hy8xmtiq 95 32 ] ] -RRB- cord-011418-hy8xmtiq 95 33 . . . cord-011418-hy8xmtiq 96 1 A a DT cord-011418-hy8xmtiq 96 2 recent recent JJ cord-011418-hy8xmtiq 96 3 study study NN cord-011418-hy8xmtiq 96 4 found find VBD cord-011418-hy8xmtiq 96 5 that that IN cord-011418-hy8xmtiq 96 6 children child NNS cord-011418-hy8xmtiq 96 7 receiving receive VBG cord-011418-hy8xmtiq 96 8 benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 96 9 had have VBD cord-011418-hy8xmtiq 96 10 over over IN cord-011418-hy8xmtiq 96 11 three three CD cord-011418-hy8xmtiq 96 12 times time NNS cord-011418-hy8xmtiq 96 13 the the DT cord-011418-hy8xmtiq 96 14 likelihood likelihood NN cord-011418-hy8xmtiq 96 15 of of IN cord-011418-hy8xmtiq 96 16 becoming become VBG cord-011418-hy8xmtiq 96 17 delirious delirious JJ cord-011418-hy8xmtiq 96 18 , , , cord-011418-hy8xmtiq 96 19 after after IN cord-011418-hy8xmtiq 96 20 controlling control VBG cord-011418-hy8xmtiq 96 21 for for IN cord-011418-hy8xmtiq 96 22 cognitive cognitive JJ cord-011418-hy8xmtiq 96 23 status status NN cord-011418-hy8xmtiq 96 24 , , , cord-011418-hy8xmtiq 96 25 mechanical mechanical JJ cord-011418-hy8xmtiq 96 26 ventilation ventilation NN cord-011418-hy8xmtiq 96 27 , , , cord-011418-hy8xmtiq 96 28 and and CC cord-011418-hy8xmtiq 96 29 opiate opiate NN cord-011418-hy8xmtiq 96 30 use use NN cord-011418-hy8xmtiq 96 31 [ [ -LRB- cord-011418-hy8xmtiq 96 32 39 39 CD cord-011418-hy8xmtiq 96 33 ] ] -RRB- cord-011418-hy8xmtiq 96 34 . . . cord-011418-hy8xmtiq 97 1 Other other JJ cord-011418-hy8xmtiq 97 2 potentially potentially RB cord-011418-hy8xmtiq 97 3 modifiable modifiable JJ cord-011418-hy8xmtiq 97 4 risk risk NN cord-011418-hy8xmtiq 97 5 factors factor NNS cord-011418-hy8xmtiq 97 6 include include VBP cord-011418-hy8xmtiq 97 7 the the DT cord-011418-hy8xmtiq 97 8 use use NN cord-011418-hy8xmtiq 97 9 of of IN cord-011418-hy8xmtiq 97 10 restraints restraint NNS cord-011418-hy8xmtiq 97 11 [ [ -LRB- cord-011418-hy8xmtiq 97 12 45• 45• CD cord-011418-hy8xmtiq 97 13 ] ] -RRB- cord-011418-hy8xmtiq 97 14 , , , cord-011418-hy8xmtiq 97 15 anticholinergic anticholinergic JJ cord-011418-hy8xmtiq 97 16 medications medication NNS cord-011418-hy8xmtiq 97 17 [ [ -LRB- cord-011418-hy8xmtiq 97 18 57 57 CD cord-011418-hy8xmtiq 97 19 , , , cord-011418-hy8xmtiq 97 20 58 58 CD cord-011418-hy8xmtiq 97 21 ] ] -RRB- cord-011418-hy8xmtiq 97 22 , , , cord-011418-hy8xmtiq 97 23 and and CC cord-011418-hy8xmtiq 97 24 red red JJ cord-011418-hy8xmtiq 97 25 blood blood NN cord-011418-hy8xmtiq 97 26 cell cell NN cord-011418-hy8xmtiq 97 27 transfusions transfusion NNS cord-011418-hy8xmtiq 97 28 [ [ -LRB- cord-011418-hy8xmtiq 97 29 59 59 CD cord-011418-hy8xmtiq 97 30 ] ] -RRB- cord-011418-hy8xmtiq 97 31 . . . cord-011418-hy8xmtiq 98 1 Delirium delirium NN cord-011418-hy8xmtiq 98 2 has have VBZ cord-011418-hy8xmtiq 98 3 multifactorial multifactorial JJ cord-011418-hy8xmtiq 98 4 etiologies etiology NNS cord-011418-hy8xmtiq 98 5 and and CC cord-011418-hy8xmtiq 98 6 triggers trigger NNS cord-011418-hy8xmtiq 98 7 ; ; : cord-011418-hy8xmtiq 98 8 it -PRON- PRP cord-011418-hy8xmtiq 98 9 can can MD cord-011418-hy8xmtiq 98 10 develop develop VB cord-011418-hy8xmtiq 98 11 as as IN cord-011418-hy8xmtiq 98 12 a a DT cord-011418-hy8xmtiq 98 13 complication complication NN cord-011418-hy8xmtiq 98 14 of of IN cord-011418-hy8xmtiq 98 15 the the DT cord-011418-hy8xmtiq 98 16 underlying underlie VBG cord-011418-hy8xmtiq 98 17 illness illness NN cord-011418-hy8xmtiq 98 18 and and CC cord-011418-hy8xmtiq 98 19 organ organ NN cord-011418-hy8xmtiq 98 20 dysfunction dysfunction NN cord-011418-hy8xmtiq 98 21 , , , cord-011418-hy8xmtiq 98 22 and and CC cord-011418-hy8xmtiq 98 23 be be VB cord-011418-hy8xmtiq 98 24 precipitated precipitate VBN cord-011418-hy8xmtiq 98 25 by by IN cord-011418-hy8xmtiq 98 26 sedation sedation NN cord-011418-hy8xmtiq 98 27 , , , cord-011418-hy8xmtiq 98 28 uncontrolled uncontrolled JJ cord-011418-hy8xmtiq 98 29 pain pain NN cord-011418-hy8xmtiq 98 30 , , , cord-011418-hy8xmtiq 98 31 withdrawal withdrawal NN cord-011418-hy8xmtiq 98 32 , , , cord-011418-hy8xmtiq 98 33 sleep sleep NN cord-011418-hy8xmtiq 98 34 disruption disruption NN cord-011418-hy8xmtiq 98 35 , , , cord-011418-hy8xmtiq 98 36 and and CC cord-011418-hy8xmtiq 98 37 the the DT cord-011418-hy8xmtiq 98 38 abnormal abnormal JJ cord-011418-hy8xmtiq 98 39 ICU ICU NNP cord-011418-hy8xmtiq 98 40 environment environment NN cord-011418-hy8xmtiq 98 41 and and CC cord-011418-hy8xmtiq 98 42 immobility immobility NN cord-011418-hy8xmtiq 98 43 . . . cord-011418-hy8xmtiq 99 1 The the DT cord-011418-hy8xmtiq 99 2 clinical clinical JJ cord-011418-hy8xmtiq 99 3 symptomatology symptomatology NN cord-011418-hy8xmtiq 99 4 of of IN cord-011418-hy8xmtiq 99 5 delirium delirium NN cord-011418-hy8xmtiq 99 6 can can MD cord-011418-hy8xmtiq 99 7 be be VB cord-011418-hy8xmtiq 99 8 difficult difficult JJ cord-011418-hy8xmtiq 99 9 to to TO cord-011418-hy8xmtiq 99 10 distinguish distinguish VB cord-011418-hy8xmtiq 99 11 from from IN cord-011418-hy8xmtiq 99 12 pain pain NN cord-011418-hy8xmtiq 99 13 and and CC cord-011418-hy8xmtiq 99 14 iatrogenic iatrogenic JJ cord-011418-hy8xmtiq 99 15 withdrawal withdrawal NN cord-011418-hy8xmtiq 99 16 syndrome syndrome NN cord-011418-hy8xmtiq 99 17 , , , cord-011418-hy8xmtiq 99 18 which which WDT cord-011418-hy8xmtiq 99 19 makes make VBZ cord-011418-hy8xmtiq 99 20 the the DT cord-011418-hy8xmtiq 99 21 use use NN cord-011418-hy8xmtiq 99 22 of of IN cord-011418-hy8xmtiq 99 23 a a DT cord-011418-hy8xmtiq 99 24 validated validate VBN cord-011418-hy8xmtiq 99 25 screening screening NN cord-011418-hy8xmtiq 99 26 tool tool NN cord-011418-hy8xmtiq 99 27 paramount paramount NN cord-011418-hy8xmtiq 99 28 in in IN cord-011418-hy8xmtiq 99 29 its -PRON- PRP$ cord-011418-hy8xmtiq 99 30 diagnosis diagnosis NN cord-011418-hy8xmtiq 99 31 ( ( -LRB- cord-011418-hy8xmtiq 99 32 Fig Fig NNP cord-011418-hy8xmtiq 99 33 . . . cord-011418-hy8xmtiq 99 34 1 1 CD cord-011418-hy8xmtiq 99 35 ) ) -RRB- cord-011418-hy8xmtiq 99 36 . . . cord-011418-hy8xmtiq 100 1 Preventing prevent VBG cord-011418-hy8xmtiq 100 2 and and CC cord-011418-hy8xmtiq 100 3 managing manage VBG cord-011418-hy8xmtiq 100 4 delirium delirium NN cord-011418-hy8xmtiq 100 5 therefore therefore RB cord-011418-hy8xmtiq 100 6 starts start VBZ cord-011418-hy8xmtiq 100 7 with with IN cord-011418-hy8xmtiq 100 8 a a DT cord-011418-hy8xmtiq 100 9 careful careful JJ cord-011418-hy8xmtiq 100 10 identification identification NN cord-011418-hy8xmtiq 100 11 of of IN cord-011418-hy8xmtiq 100 12 triggers trigger NNS cord-011418-hy8xmtiq 100 13 and and CC cord-011418-hy8xmtiq 100 14 the the DT cord-011418-hy8xmtiq 100 15 underlying underlie VBG cord-011418-hy8xmtiq 100 16 etiology etiology NN cord-011418-hy8xmtiq 100 17 . . . cord-011418-hy8xmtiq 101 1 There there EX cord-011418-hy8xmtiq 101 2 is be VBZ cord-011418-hy8xmtiq 101 3 a a DT cord-011418-hy8xmtiq 101 4 paucity paucity NN cord-011418-hy8xmtiq 101 5 of of IN cord-011418-hy8xmtiq 101 6 evidence evidence NN cord-011418-hy8xmtiq 101 7 to to TO cord-011418-hy8xmtiq 101 8 truly truly RB cord-011418-hy8xmtiq 101 9 guide guide VB cord-011418-hy8xmtiq 101 10 the the DT cord-011418-hy8xmtiq 101 11 prevention prevention NN cord-011418-hy8xmtiq 101 12 and and CC cord-011418-hy8xmtiq 101 13 management management NN cord-011418-hy8xmtiq 101 14 of of IN cord-011418-hy8xmtiq 101 15 pediatric pediatric JJ cord-011418-hy8xmtiq 101 16 delirium delirium NN cord-011418-hy8xmtiq 101 17 . . . cord-011418-hy8xmtiq 102 1 Studies study NNS cord-011418-hy8xmtiq 102 2 in in IN cord-011418-hy8xmtiq 102 3 adult adult NN cord-011418-hy8xmtiq 102 4 ICU ICU NNP cord-011418-hy8xmtiq 102 5 patients patient NNS cord-011418-hy8xmtiq 102 6 have have VBP cord-011418-hy8xmtiq 102 7 shown show VBN cord-011418-hy8xmtiq 102 8 that that IN cord-011418-hy8xmtiq 102 9 implementation implementation NN cord-011418-hy8xmtiq 102 10 and and CC cord-011418-hy8xmtiq 102 11 adherence adherence NN cord-011418-hy8xmtiq 102 12 to to IN cord-011418-hy8xmtiq 102 13 the the DT cord-011418-hy8xmtiq 102 14 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 102 15 liberation liberation NN cord-011418-hy8xmtiq 102 16 bundle bundle NN cord-011418-hy8xmtiq 102 17 had have VBD cord-011418-hy8xmtiq 102 18 a a DT cord-011418-hy8xmtiq 102 19 significantly significantly RB cord-011418-hy8xmtiq 102 20 lower low JJR cord-011418-hy8xmtiq 102 21 risk risk NN cord-011418-hy8xmtiq 102 22 of of IN cord-011418-hy8xmtiq 102 23 delirium delirium NN cord-011418-hy8xmtiq 102 24 [ [ -LRB- cord-011418-hy8xmtiq 102 25 18•• 18•• CD cord-011418-hy8xmtiq 102 26 ] ] -RRB- cord-011418-hy8xmtiq 102 27 . . . cord-011418-hy8xmtiq 103 1 Recent recent JJ cord-011418-hy8xmtiq 103 2 studies study NNS cord-011418-hy8xmtiq 103 3 in in IN cord-011418-hy8xmtiq 103 4 adults adult NNS cord-011418-hy8xmtiq 103 5 have have VBP cord-011418-hy8xmtiq 103 6 shown show VBN cord-011418-hy8xmtiq 103 7 that that IN cord-011418-hy8xmtiq 103 8 antipsychotics antipsychotic NNS cord-011418-hy8xmtiq 103 9 are be VBP cord-011418-hy8xmtiq 103 10 not not RB cord-011418-hy8xmtiq 103 11 effective effective JJ cord-011418-hy8xmtiq 103 12 in in IN cord-011418-hy8xmtiq 103 13 significantly significantly RB cord-011418-hy8xmtiq 103 14 decreasing decrease VBG cord-011418-hy8xmtiq 103 15 the the DT cord-011418-hy8xmtiq 103 16 duration duration NN cord-011418-hy8xmtiq 103 17 of of IN cord-011418-hy8xmtiq 103 18 delirium delirium NN cord-011418-hy8xmtiq 103 19 [ [ -LRB- cord-011418-hy8xmtiq 103 20 60 60 CD cord-011418-hy8xmtiq 103 21 ] ] -RRB- cord-011418-hy8xmtiq 103 22 . . . cord-011418-hy8xmtiq 104 1 Antipsychotics antipsychotic NNS cord-011418-hy8xmtiq 104 2 can can MD cord-011418-hy8xmtiq 104 3 be be VB cord-011418-hy8xmtiq 104 4 helpful helpful JJ cord-011418-hy8xmtiq 104 5 for for IN cord-011418-hy8xmtiq 104 6 symptomatic symptomatic JJ cord-011418-hy8xmtiq 104 7 management management NN cord-011418-hy8xmtiq 104 8 when when WRB cord-011418-hy8xmtiq 104 9 a a DT cord-011418-hy8xmtiq 104 10 child child NN cord-011418-hy8xmtiq 104 11 continues continue VBZ cord-011418-hy8xmtiq 104 12 to to TO cord-011418-hy8xmtiq 104 13 experience experience VB cord-011418-hy8xmtiq 104 14 delirium delirium NN cord-011418-hy8xmtiq 104 15 despite despite IN cord-011418-hy8xmtiq 104 16 the the DT cord-011418-hy8xmtiq 104 17 optimal optimal JJ cord-011418-hy8xmtiq 104 18 management management NN cord-011418-hy8xmtiq 104 19 of of IN cord-011418-hy8xmtiq 104 20 the the DT cord-011418-hy8xmtiq 104 21 underlying underlie VBG cord-011418-hy8xmtiq 104 22 illness illness NN cord-011418-hy8xmtiq 104 23 and and CC cord-011418-hy8xmtiq 104 24 minimizing minimize VBG cord-011418-hy8xmtiq 104 25 iatrogenic iatrogenic JJ cord-011418-hy8xmtiq 104 26 triggers trigger NNS cord-011418-hy8xmtiq 104 27 . . . cord-011418-hy8xmtiq 105 1 Although although IN cord-011418-hy8xmtiq 105 2 this this DT cord-011418-hy8xmtiq 105 3 represents represent VBZ cord-011418-hy8xmtiq 105 4 offlabel offlabel NN cord-011418-hy8xmtiq 105 5 use use NN cord-011418-hy8xmtiq 105 6 , , , cord-011418-hy8xmtiq 105 7 quetiapine quetiapine NNP cord-011418-hy8xmtiq 105 8 was be VBD cord-011418-hy8xmtiq 105 9 shown show VBN cord-011418-hy8xmtiq 105 10 to to TO cord-011418-hy8xmtiq 105 11 be be VB cord-011418-hy8xmtiq 105 12 safe safe JJ cord-011418-hy8xmtiq 105 13 and and CC cord-011418-hy8xmtiq 105 14 effective effective JJ cord-011418-hy8xmtiq 105 15 in in IN cord-011418-hy8xmtiq 105 16 a a DT cord-011418-hy8xmtiq 105 17 randomized randomized JJ cord-011418-hy8xmtiq 105 18 controlled control VBN cord-011418-hy8xmtiq 105 19 trial trial NN cord-011418-hy8xmtiq 105 20 [ [ -LRB- cord-011418-hy8xmtiq 105 21 61 61 CD cord-011418-hy8xmtiq 105 22 ] ] -RRB- cord-011418-hy8xmtiq 105 23 , , , cord-011418-hy8xmtiq 105 24 and and CC cord-011418-hy8xmtiq 105 25 case case NN cord-011418-hy8xmtiq 105 26 studies study NNS cord-011418-hy8xmtiq 105 27 suggest suggest VBP cord-011418-hy8xmtiq 105 28 the the DT cord-011418-hy8xmtiq 105 29 same same JJ cord-011418-hy8xmtiq 105 30 for for IN cord-011418-hy8xmtiq 105 31 risperidone risperidone NNP cord-011418-hy8xmtiq 105 32 and and CC cord-011418-hy8xmtiq 105 33 olanzapine olanzapine NNP cord-011418-hy8xmtiq 105 34 [ [ -LRB- cord-011418-hy8xmtiq 105 35 62 62 CD cord-011418-hy8xmtiq 105 36 ] ] -RRB- cord-011418-hy8xmtiq 105 37 [ [ -LRB- cord-011418-hy8xmtiq 105 38 63 63 CD cord-011418-hy8xmtiq 105 39 ] ] -RRB- cord-011418-hy8xmtiq 105 40 [ [ -LRB- cord-011418-hy8xmtiq 105 41 64 64 CD cord-011418-hy8xmtiq 105 42 ] ] -RRB- cord-011418-hy8xmtiq 105 43 . . . cord-011418-hy8xmtiq 106 1 Tips tip NNS cord-011418-hy8xmtiq 106 2 for for IN cord-011418-hy8xmtiq 106 3 Implementation implementation NN cord-011418-hy8xmtiq 106 4 Start Start NNP cord-011418-hy8xmtiq 106 5 by by IN cord-011418-hy8xmtiq 106 6 choosing choose VBG cord-011418-hy8xmtiq 106 7 a a DT cord-011418-hy8xmtiq 106 8 validated validate VBN cord-011418-hy8xmtiq 106 9 screening screening NN cord-011418-hy8xmtiq 106 10 tool tool NN cord-011418-hy8xmtiq 106 11 for for IN cord-011418-hy8xmtiq 106 12 delirium delirium NN cord-011418-hy8xmtiq 106 13 and and CC cord-011418-hy8xmtiq 106 14 integrating integrate VBG cord-011418-hy8xmtiq 106 15 it -PRON- PRP cord-011418-hy8xmtiq 106 16 into into IN cord-011418-hy8xmtiq 106 17 the the DT cord-011418-hy8xmtiq 106 18 nursing nursing NN cord-011418-hy8xmtiq 106 19 assessment assessment NN cord-011418-hy8xmtiq 106 20 . . . cord-011418-hy8xmtiq 107 1 Avoid avoid VB cord-011418-hy8xmtiq 107 2 unnecessary unnecessary JJ cord-011418-hy8xmtiq 107 3 sedation sedation NN cord-011418-hy8xmtiq 107 4 and and CC cord-011418-hy8xmtiq 107 5 avoid avoid VB cord-011418-hy8xmtiq 107 6 the the DT cord-011418-hy8xmtiq 107 7 use use NN cord-011418-hy8xmtiq 107 8 of of IN cord-011418-hy8xmtiq 107 9 benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 107 10 whenever whenever WRB cord-011418-hy8xmtiq 107 11 possible possible JJ cord-011418-hy8xmtiq 107 12 . . . cord-011418-hy8xmtiq 108 1 Once once IN cord-011418-hy8xmtiq 108 2 delirium delirium NN cord-011418-hy8xmtiq 108 3 is be VBZ cord-011418-hy8xmtiq 108 4 diagnosed diagnose VBN cord-011418-hy8xmtiq 108 5 , , , cord-011418-hy8xmtiq 108 6 a a DT cord-011418-hy8xmtiq 108 7 careful careful JJ cord-011418-hy8xmtiq 108 8 evaluation evaluation NN cord-011418-hy8xmtiq 108 9 of of IN cord-011418-hy8xmtiq 108 10 inciting incite VBG cord-011418-hy8xmtiq 108 11 events event NNS cord-011418-hy8xmtiq 108 12 and and CC cord-011418-hy8xmtiq 108 13 etiology etiology NN cord-011418-hy8xmtiq 108 14 is be VBZ cord-011418-hy8xmtiq 108 15 warranted warrant VBN cord-011418-hy8xmtiq 108 16 . . . cord-011418-hy8xmtiq 109 1 The the DT cord-011418-hy8xmtiq 109 2 off off JJ cord-011418-hy8xmtiq 109 3 - - HYPH cord-011418-hy8xmtiq 109 4 label label NN cord-011418-hy8xmtiq 109 5 use use NN cord-011418-hy8xmtiq 109 6 of of IN cord-011418-hy8xmtiq 109 7 atypical atypical JJ cord-011418-hy8xmtiq 109 8 antipsychotics antipsychotic NNS cord-011418-hy8xmtiq 109 9 can can MD cord-011418-hy8xmtiq 109 10 be be VB cord-011418-hy8xmtiq 109 11 helpful helpful JJ cord-011418-hy8xmtiq 109 12 in in IN cord-011418-hy8xmtiq 109 13 symptomatic symptomatic JJ cord-011418-hy8xmtiq 109 14 management management NN cord-011418-hy8xmtiq 109 15 if if IN cord-011418-hy8xmtiq 109 16 delirium delirium NN cord-011418-hy8xmtiq 109 17 persists persist VBZ cord-011418-hy8xmtiq 109 18 . . . cord-011418-hy8xmtiq 110 1 ICU ICU NNP cord-011418-hy8xmtiq 110 2 - - HYPH cord-011418-hy8xmtiq 110 3 acquired acquire VBN cord-011418-hy8xmtiq 110 4 weakness weakness NN cord-011418-hy8xmtiq 110 5 is be VBZ cord-011418-hy8xmtiq 110 6 a a DT cord-011418-hy8xmtiq 110 7 well well RB cord-011418-hy8xmtiq 110 8 - - HYPH cord-011418-hy8xmtiq 110 9 described describe VBN cord-011418-hy8xmtiq 110 10 phenomenon phenomenon NN cord-011418-hy8xmtiq 110 11 in in IN cord-011418-hy8xmtiq 110 12 adults adult NNS cord-011418-hy8xmtiq 110 13 [ [ -LRB- cord-011418-hy8xmtiq 110 14 65 65 CD cord-011418-hy8xmtiq 110 15 ] ] -RRB- cord-011418-hy8xmtiq 111 1 [ [ -LRB- cord-011418-hy8xmtiq 111 2 66 66 CD cord-011418-hy8xmtiq 111 3 ] ] -RRB- cord-011418-hy8xmtiq 112 1 [ [ -LRB- cord-011418-hy8xmtiq 112 2 67 67 CD cord-011418-hy8xmtiq 112 3 ] ] -RRB- cord-011418-hy8xmtiq 112 4 and and CC cord-011418-hy8xmtiq 112 5 children child NNS cord-011418-hy8xmtiq 113 1 [ [ -LRB- cord-011418-hy8xmtiq 113 2 68 68 CD cord-011418-hy8xmtiq 113 3 ] ] -RRB- cord-011418-hy8xmtiq 113 4 [ [ -LRB- cord-011418-hy8xmtiq 113 5 69 69 CD cord-011418-hy8xmtiq 113 6 ] ] -RRB- cord-011418-hy8xmtiq 113 7 [ [ -LRB- cord-011418-hy8xmtiq 113 8 70 70 CD cord-011418-hy8xmtiq 113 9 ] ] -RRB- cord-011418-hy8xmtiq 113 10 [ [ -LRB- cord-011418-hy8xmtiq 113 11 71 71 CD cord-011418-hy8xmtiq 113 12 ] ] -RRB- cord-011418-hy8xmtiq 113 13 . . . cord-011418-hy8xmtiq 114 1 Early early JJ cord-011418-hy8xmtiq 114 2 mobility mobility NN cord-011418-hy8xmtiq 114 3 ( ( -LRB- cord-011418-hy8xmtiq 114 4 EM EM NNP cord-011418-hy8xmtiq 114 5 ) ) -RRB- cord-011418-hy8xmtiq 114 6 [ [ -LRB- cord-011418-hy8xmtiq 114 7 72 72 CD cord-011418-hy8xmtiq 114 8 ] ] -RRB- cord-011418-hy8xmtiq 114 9 , , , cord-011418-hy8xmtiq 114 10 the the DT cord-011418-hy8xmtiq 114 11 practice practice NN cord-011418-hy8xmtiq 114 12 of of IN cord-011418-hy8xmtiq 114 13 physical physical JJ cord-011418-hy8xmtiq 114 14 and and CC cord-011418-hy8xmtiq 114 15 occupational occupational JJ cord-011418-hy8xmtiq 114 16 therapy therapy NN cord-011418-hy8xmtiq 114 17 early early RB cord-011418-hy8xmtiq 114 18 during during IN cord-011418-hy8xmtiq 114 19 critical critical JJ cord-011418-hy8xmtiq 114 20 illness illness NN cord-011418-hy8xmtiq 114 21 , , , cord-011418-hy8xmtiq 114 22 is be VBZ cord-011418-hy8xmtiq 114 23 used use VBN cord-011418-hy8xmtiq 114 24 to to TO cord-011418-hy8xmtiq 114 25 prevent prevent VB cord-011418-hy8xmtiq 114 26 and and CC cord-011418-hy8xmtiq 114 27 treat treat VB cord-011418-hy8xmtiq 114 28 ICUacquired icuacquire VBN cord-011418-hy8xmtiq 114 29 weakness weakness NN cord-011418-hy8xmtiq 114 30 . . . cord-011418-hy8xmtiq 115 1 Biopsies biopsy NNS cord-011418-hy8xmtiq 115 2 in in IN cord-011418-hy8xmtiq 115 3 adults adult NNS cord-011418-hy8xmtiq 115 4 with with IN cord-011418-hy8xmtiq 115 5 septic septic JJ cord-011418-hy8xmtiq 115 6 shock shock NN cord-011418-hy8xmtiq 115 7 suggest suggest VBP cord-011418-hy8xmtiq 115 8 early early JJ cord-011418-hy8xmtiq 115 9 mobility mobility NN cord-011418-hy8xmtiq 115 10 may may MD cord-011418-hy8xmtiq 115 11 maintain maintain VB cord-011418-hy8xmtiq 115 12 muscle muscle NN cord-011418-hy8xmtiq 115 13 fibers fiber NNS cord-011418-hy8xmtiq 115 14 and and CC cord-011418-hy8xmtiq 115 15 lessen lessen VB cord-011418-hy8xmtiq 115 16 the the DT cord-011418-hy8xmtiq 115 17 muscle muscle NN cord-011418-hy8xmtiq 115 18 atrophy atrophy NN cord-011418-hy8xmtiq 115 19 associated associate VBN cord-011418-hy8xmtiq 115 20 with with IN cord-011418-hy8xmtiq 115 21 critical critical JJ cord-011418-hy8xmtiq 115 22 illness illness NN cord-011418-hy8xmtiq 115 23 [ [ -LRB- cord-011418-hy8xmtiq 115 24 73 73 CD cord-011418-hy8xmtiq 115 25 ] ] -RRB- cord-011418-hy8xmtiq 115 26 . . . cord-011418-hy8xmtiq 116 1 Adult adult NN cord-011418-hy8xmtiq 116 2 studies study NNS cord-011418-hy8xmtiq 116 3 have have VBP cord-011418-hy8xmtiq 116 4 shown show VBN cord-011418-hy8xmtiq 116 5 several several JJ cord-011418-hy8xmtiq 116 6 other other JJ cord-011418-hy8xmtiq 116 7 benefits benefit NNS cord-011418-hy8xmtiq 116 8 of of IN cord-011418-hy8xmtiq 116 9 EM EM NNP cord-011418-hy8xmtiq 116 10 , , , cord-011418-hy8xmtiq 116 11 including include VBG cord-011418-hy8xmtiq 116 12 decreased decrease VBD cord-011418-hy8xmtiq 116 13 delirium delirium NN cord-011418-hy8xmtiq 116 14 incidence incidence NN cord-011418-hy8xmtiq 116 15 , , , cord-011418-hy8xmtiq 116 16 decreased decrease VBD cord-011418-hy8xmtiq 116 17 ICU ICU NNP cord-011418-hy8xmtiq 116 18 length length NN cord-011418-hy8xmtiq 116 19 of of IN cord-011418-hy8xmtiq 116 20 stay stay NN cord-011418-hy8xmtiq 116 21 , , , cord-011418-hy8xmtiq 116 22 decreased decrease VBD cord-011418-hy8xmtiq 116 23 hospital hospital NN cord-011418-hy8xmtiq 116 24 length length NN cord-011418-hy8xmtiq 116 25 of of IN cord-011418-hy8xmtiq 116 26 stay stay NN cord-011418-hy8xmtiq 116 27 , , , cord-011418-hy8xmtiq 116 28 decreased decrease VBD cord-011418-hy8xmtiq 116 29 ventilator ventilator NN cord-011418-hy8xmtiq 116 30 days day NNS cord-011418-hy8xmtiq 116 31 , , , cord-011418-hy8xmtiq 116 32 and and CC cord-011418-hy8xmtiq 116 33 earlier early JJR cord-011418-hy8xmtiq 116 34 attainment attainment NN cord-011418-hy8xmtiq 116 35 of of IN cord-011418-hy8xmtiq 116 36 activities activity NNS cord-011418-hy8xmtiq 116 37 of of IN cord-011418-hy8xmtiq 116 38 daily daily JJ cord-011418-hy8xmtiq 116 39 living live VBG cord-011418-hy8xmtiq 116 40 [ [ -LRB- cord-011418-hy8xmtiq 116 41 74 74 CD cord-011418-hy8xmtiq 116 42 ] ] -RRB- cord-011418-hy8xmtiq 116 43 [ [ -LRB- cord-011418-hy8xmtiq 116 44 75 75 CD cord-011418-hy8xmtiq 116 45 ] ] -RRB- cord-011418-hy8xmtiq 116 46 [ [ -LRB- cord-011418-hy8xmtiq 116 47 76 76 CD cord-011418-hy8xmtiq 116 48 ] ] -RRB- cord-011418-hy8xmtiq 116 49 [ [ -LRB- cord-011418-hy8xmtiq 116 50 77 77 CD cord-011418-hy8xmtiq 116 51 ] ] -RRB- cord-011418-hy8xmtiq 116 52 . . . cord-011418-hy8xmtiq 117 1 Varied varied JJ cord-011418-hy8xmtiq 117 2 developmental developmental JJ cord-011418-hy8xmtiq 117 3 stages stage NNS cord-011418-hy8xmtiq 117 4 and and CC cord-011418-hy8xmtiq 117 5 a a DT cord-011418-hy8xmtiq 117 6 broad broad JJ cord-011418-hy8xmtiq 117 7 spectrum spectrum NN cord-011418-hy8xmtiq 117 8 of of IN cord-011418-hy8xmtiq 117 9 ages age NNS cord-011418-hy8xmtiq 117 10 can can MD cord-011418-hy8xmtiq 117 11 make make VB cord-011418-hy8xmtiq 117 12 EM EM NNP cord-011418-hy8xmtiq 117 13 more more RBR cord-011418-hy8xmtiq 117 14 challenging challenging JJ cord-011418-hy8xmtiq 117 15 in in IN cord-011418-hy8xmtiq 117 16 pediatrics pediatric NNS cord-011418-hy8xmtiq 117 17 [ [ -LRB- cord-011418-hy8xmtiq 117 18 78 78 CD cord-011418-hy8xmtiq 117 19 ] ] -RRB- cord-011418-hy8xmtiq 117 20 . . . cord-011418-hy8xmtiq 118 1 In in IN cord-011418-hy8xmtiq 118 2 addition addition NN cord-011418-hy8xmtiq 118 3 to to IN cord-011418-hy8xmtiq 118 4 protocolization protocolization NN cord-011418-hy8xmtiq 118 5 and and CC cord-011418-hy8xmtiq 118 6 equipment equipment NN cord-011418-hy8xmtiq 118 7 barriers barrier NNS cord-011418-hy8xmtiq 118 8 , , , cord-011418-hy8xmtiq 118 9 many many JJ cord-011418-hy8xmtiq 118 10 studies study NNS cord-011418-hy8xmtiq 118 11 have have VBP cord-011418-hy8xmtiq 118 12 found find VBN cord-011418-hy8xmtiq 118 13 staff staff NN cord-011418-hy8xmtiq 118 14 perceptions perception NNS cord-011418-hy8xmtiq 118 15 to to TO cord-011418-hy8xmtiq 118 16 be be VB cord-011418-hy8xmtiq 118 17 a a DT cord-011418-hy8xmtiq 118 18 significant significant JJ cord-011418-hy8xmtiq 118 19 barrier barrier NN cord-011418-hy8xmtiq 118 20 [ [ -LRB- cord-011418-hy8xmtiq 118 21 78 78 CD cord-011418-hy8xmtiq 118 22 , , , cord-011418-hy8xmtiq 118 23 79 79 CD cord-011418-hy8xmtiq 118 24 ] ] -RRB- cord-011418-hy8xmtiq 118 25 . . . cord-011418-hy8xmtiq 119 1 However however RB cord-011418-hy8xmtiq 119 2 , , , cord-011418-hy8xmtiq 119 3 a a DT cord-011418-hy8xmtiq 119 4 systematic systematic JJ cord-011418-hy8xmtiq 119 5 review review NN cord-011418-hy8xmtiq 119 6 of of IN cord-011418-hy8xmtiq 119 7 11 11 CD cord-011418-hy8xmtiq 119 8 pediatric pediatric JJ cord-011418-hy8xmtiq 119 9 EM EM NNP cord-011418-hy8xmtiq 119 10 studies study NNS cord-011418-hy8xmtiq 119 11 and and CC cord-011418-hy8xmtiq 119 12 over over IN cord-011418-hy8xmtiq 119 13 1100 1100 CD cord-011418-hy8xmtiq 119 14 patients patient NNS cord-011418-hy8xmtiq 119 15 found find VBD cord-011418-hy8xmtiq 119 16 only only RB cord-011418-hy8xmtiq 119 17 1 1 CD cord-011418-hy8xmtiq 119 18 % % NN cord-011418-hy8xmtiq 119 19 of of IN cord-011418-hy8xmtiq 119 20 patients patient NNS cord-011418-hy8xmtiq 119 21 had have VBD cord-011418-hy8xmtiq 119 22 any any DT cord-011418-hy8xmtiq 119 23 type type NN cord-011418-hy8xmtiq 119 24 of of IN cord-011418-hy8xmtiq 119 25 adverse adverse JJ cord-011418-hy8xmtiq 119 26 event event NN cord-011418-hy8xmtiq 119 27 related relate VBN cord-011418-hy8xmtiq 119 28 to to IN cord-011418-hy8xmtiq 119 29 EM EM NNP cord-011418-hy8xmtiq 119 30 , , , cord-011418-hy8xmtiq 119 31 suggesting suggest VBG cord-011418-hy8xmtiq 119 32 EM EM NNP cord-011418-hy8xmtiq 119 33 is be VBZ cord-011418-hy8xmtiq 119 34 also also RB cord-011418-hy8xmtiq 119 35 safe safe JJ cord-011418-hy8xmtiq 119 36 in in IN cord-011418-hy8xmtiq 119 37 the the DT cord-011418-hy8xmtiq 119 38 PICU PICU NNP cord-011418-hy8xmtiq 119 39 population population NN cord-011418-hy8xmtiq 119 40 [ [ -LRB- cord-011418-hy8xmtiq 119 41 80 80 CD cord-011418-hy8xmtiq 119 42 ] ] -RRB- cord-011418-hy8xmtiq 119 43 . . . cord-011418-hy8xmtiq 120 1 Staff staff NN cord-011418-hy8xmtiq 120 2 perceptions perception NNS cord-011418-hy8xmtiq 120 3 may may MD cord-011418-hy8xmtiq 120 4 be be VB cord-011418-hy8xmtiq 120 5 amenable amenable JJ cord-011418-hy8xmtiq 120 6 to to TO cord-011418-hy8xmtiq 120 7 change change VB cord-011418-hy8xmtiq 120 8 with with IN cord-011418-hy8xmtiq 120 9 education education NN cord-011418-hy8xmtiq 120 10 and and CC cord-011418-hy8xmtiq 120 11 development development NN cord-011418-hy8xmtiq 120 12 of of IN cord-011418-hy8xmtiq 120 13 a a DT cord-011418-hy8xmtiq 120 14 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 120 15 protocol protocol NN cord-011418-hy8xmtiq 120 16 [ [ -LRB- cord-011418-hy8xmtiq 120 17 79 79 CD cord-011418-hy8xmtiq 120 18 ] ] -RRB- cord-011418-hy8xmtiq 120 19 . . . cord-011418-hy8xmtiq 121 1 EM EM NNP cord-011418-hy8xmtiq 121 2 outcomes outcome NNS cord-011418-hy8xmtiq 121 3 data datum NNS cord-011418-hy8xmtiq 121 4 in in IN cord-011418-hy8xmtiq 121 5 pediatrics pediatric NNS cord-011418-hy8xmtiq 121 6 is be VBZ cord-011418-hy8xmtiq 121 7 sparse sparse JJ cord-011418-hy8xmtiq 121 8 , , , cord-011418-hy8xmtiq 121 9 but but CC cord-011418-hy8xmtiq 121 10 several several JJ cord-011418-hy8xmtiq 121 11 studies study NNS cord-011418-hy8xmtiq 121 12 have have VBP cord-011418-hy8xmtiq 121 13 demonstrated demonstrate VBN cord-011418-hy8xmtiq 121 14 feasibility feasibility NN cord-011418-hy8xmtiq 121 15 [ [ -LRB- cord-011418-hy8xmtiq 121 16 78 78 CD cord-011418-hy8xmtiq 121 17 , , , cord-011418-hy8xmtiq 121 18 81 81 CD cord-011418-hy8xmtiq 121 19 - - SYM cord-011418-hy8xmtiq 121 20 84 84 CD cord-011418-hy8xmtiq 121 21 , , , cord-011418-hy8xmtiq 121 22 85• 85• CD cord-011418-hy8xmtiq 121 23 ] ] -RRB- cord-011418-hy8xmtiq 121 24 . . . cord-011418-hy8xmtiq 122 1 Two two CD cord-011418-hy8xmtiq 122 2 pediatric pediatric JJ cord-011418-hy8xmtiq 122 3 studies study NNS cord-011418-hy8xmtiq 122 4 have have VBP cord-011418-hy8xmtiq 122 5 found find VBN cord-011418-hy8xmtiq 122 6 significant significant JJ cord-011418-hy8xmtiq 122 7 clinical clinical JJ cord-011418-hy8xmtiq 122 8 benefits benefit NNS cord-011418-hy8xmtiq 122 9 related relate VBN cord-011418-hy8xmtiq 122 10 to to IN cord-011418-hy8xmtiq 122 11 EM EM NNP cord-011418-hy8xmtiq 122 12 . . . cord-011418-hy8xmtiq 123 1 In in IN cord-011418-hy8xmtiq 123 2 a a DT cord-011418-hy8xmtiq 123 3 single single JJ cord-011418-hy8xmtiq 123 4 - - HYPH cord-011418-hy8xmtiq 123 5 center center NN cord-011418-hy8xmtiq 123 6 pre pre JJ cord-011418-hy8xmtiq 123 7 - - JJ cord-011418-hy8xmtiq 123 8 post post JJ cord-011418-hy8xmtiq 123 9 cohort cohort NN cord-011418-hy8xmtiq 123 10 of of IN cord-011418-hy8xmtiq 123 11 pediatric pediatric JJ cord-011418-hy8xmtiq 123 12 liver liver NN cord-011418-hy8xmtiq 123 13 transplant transplant NN cord-011418-hy8xmtiq 123 14 patients patient NNS cord-011418-hy8xmtiq 123 15 , , , cord-011418-hy8xmtiq 123 16 implementation implementation NN cord-011418-hy8xmtiq 123 17 of of IN cord-011418-hy8xmtiq 123 18 an an DT cord-011418-hy8xmtiq 123 19 EM EM NNP cord-011418-hy8xmtiq 123 20 program program NN cord-011418-hy8xmtiq 123 21 resulted result VBD cord-011418-hy8xmtiq 123 22 in in IN cord-011418-hy8xmtiq 123 23 faster fast JJR cord-011418-hy8xmtiq 123 24 ambulation ambulation NN cord-011418-hy8xmtiq 123 25 and and CC cord-011418-hy8xmtiq 123 26 shorter short JJR cord-011418-hy8xmtiq 123 27 hospital hospital NN cord-011418-hy8xmtiq 123 28 length length NN cord-011418-hy8xmtiq 123 29 of of IN cord-011418-hy8xmtiq 123 30 stay stay NN cord-011418-hy8xmtiq 123 31 [ [ -LRB- cord-011418-hy8xmtiq 123 32 86• 86• CD cord-011418-hy8xmtiq 123 33 ] ] -RRB- cord-011418-hy8xmtiq 123 34 . . . cord-011418-hy8xmtiq 124 1 Simone Simone NNP cord-011418-hy8xmtiq 124 2 et et NNP cord-011418-hy8xmtiq 124 3 al al NNP cord-011418-hy8xmtiq 124 4 . . . cord-011418-hy8xmtiq 125 1 instituted institute VBN cord-011418-hy8xmtiq 125 2 delirium delirium NN cord-011418-hy8xmtiq 125 3 screening screening NN cord-011418-hy8xmtiq 125 4 , , , cord-011418-hy8xmtiq 125 5 protocolized protocolized JJ cord-011418-hy8xmtiq 125 6 sedation sedation NN cord-011418-hy8xmtiq 125 7 , , , cord-011418-hy8xmtiq 125 8 and and CC cord-011418-hy8xmtiq 125 9 an an DT cord-011418-hy8xmtiq 125 10 EM EM NNP cord-011418-hy8xmtiq 125 11 protocol protocol NN cord-011418-hy8xmtiq 125 12 in in IN cord-011418-hy8xmtiq 125 13 a a DT cord-011418-hy8xmtiq 125 14 staged stage VBN cord-011418-hy8xmtiq 125 15 approach approach NN cord-011418-hy8xmtiq 125 16 in in IN cord-011418-hy8xmtiq 125 17 single single JJ cord-011418-hy8xmtiq 125 18 - - HYPH cord-011418-hy8xmtiq 125 19 center center NN cord-011418-hy8xmtiq 125 20 PICU PICU NNP cord-011418-hy8xmtiq 125 21 and and CC cord-011418-hy8xmtiq 125 22 noted note VBD cord-011418-hy8xmtiq 125 23 decreased decreased JJ cord-011418-hy8xmtiq 125 24 incidence incidence NN cord-011418-hy8xmtiq 125 25 of of IN cord-011418-hy8xmtiq 125 26 delirium delirium NN cord-011418-hy8xmtiq 125 27 after after IN cord-011418-hy8xmtiq 125 28 implementation implementation NN cord-011418-hy8xmtiq 125 29 of of IN cord-011418-hy8xmtiq 125 30 EM EM NNP cord-011418-hy8xmtiq 125 31 [ [ -LRB- cord-011418-hy8xmtiq 125 32 85• 85• CD cord-011418-hy8xmtiq 125 33 ] ] -RRB- cord-011418-hy8xmtiq 125 34 . . . cord-011418-hy8xmtiq 126 1 Further further JJ cord-011418-hy8xmtiq 126 2 studies study NNS cord-011418-hy8xmtiq 126 3 are be VBP cord-011418-hy8xmtiq 126 4 needed need VBN cord-011418-hy8xmtiq 126 5 to to TO cord-011418-hy8xmtiq 126 6 elucidate elucidate VB cord-011418-hy8xmtiq 126 7 the the DT cord-011418-hy8xmtiq 126 8 clinical clinical JJ cord-011418-hy8xmtiq 126 9 benefits benefit NNS cord-011418-hy8xmtiq 126 10 of of IN cord-011418-hy8xmtiq 126 11 EM EM NNP cord-011418-hy8xmtiq 126 12 in in IN cord-011418-hy8xmtiq 126 13 the the DT cord-011418-hy8xmtiq 126 14 PICU PICU NNP cord-011418-hy8xmtiq 126 15 population population NN cord-011418-hy8xmtiq 126 16 . . . cord-011418-hy8xmtiq 127 1 Tips tip NNS cord-011418-hy8xmtiq 127 2 for for IN cord-011418-hy8xmtiq 127 3 Implementation implementation NN cord-011418-hy8xmtiq 127 4 Engage engage VB cord-011418-hy8xmtiq 127 5 key key JJ cord-011418-hy8xmtiq 127 6 stakeholders stakeholder NNS cord-011418-hy8xmtiq 127 7 early early RB cord-011418-hy8xmtiq 127 8 and and CC cord-011418-hy8xmtiq 127 9 build build VB cord-011418-hy8xmtiq 127 10 a a DT cord-011418-hy8xmtiq 127 11 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 127 12 committee committee NN cord-011418-hy8xmtiq 127 13 ( ( -LRB- cord-011418-hy8xmtiq 127 14 i.e. i.e. FW cord-011418-hy8xmtiq 127 15 , , , cord-011418-hy8xmtiq 127 16 physical physical JJ cord-011418-hy8xmtiq 127 17 therapy therapy NN cord-011418-hy8xmtiq 127 18 , , , cord-011418-hy8xmtiq 127 19 occupational occupational JJ cord-011418-hy8xmtiq 127 20 therapy therapy NN cord-011418-hy8xmtiq 127 21 , , , cord-011418-hy8xmtiq 127 22 nursing nursing NN cord-011418-hy8xmtiq 127 23 , , , cord-011418-hy8xmtiq 127 24 respiratory respiratory JJ cord-011418-hy8xmtiq 127 25 therapy therapy NN cord-011418-hy8xmtiq 127 26 , , , cord-011418-hy8xmtiq 127 27 administration administration NN cord-011418-hy8xmtiq 127 28 , , , cord-011418-hy8xmtiq 127 29 physicians physician NNS cord-011418-hy8xmtiq 127 30 and and CC cord-011418-hy8xmtiq 127 31 nurse nurse NN cord-011418-hy8xmtiq 127 32 practitioners practitioner NNS cord-011418-hy8xmtiq 127 33 or or CC cord-011418-hy8xmtiq 127 34 physician physician NN cord-011418-hy8xmtiq 127 35 assistants assistant NNS cord-011418-hy8xmtiq 127 36 , , , cord-011418-hy8xmtiq 127 37 child child NN cord-011418-hy8xmtiq 127 38 life life NN cord-011418-hy8xmtiq 127 39 specialists specialist NNS cord-011418-hy8xmtiq 127 40 , , , cord-011418-hy8xmtiq 127 41 speech speech NN cord-011418-hy8xmtiq 127 42 therapists therapist NNS cord-011418-hy8xmtiq 127 43 ) ) -RRB- cord-011418-hy8xmtiq 127 44 to to TO cord-011418-hy8xmtiq 127 45 create create VB cord-011418-hy8xmtiq 127 46 , , , cord-011418-hy8xmtiq 127 47 champion champion NN cord-011418-hy8xmtiq 127 48 , , , cord-011418-hy8xmtiq 127 49 and and CC cord-011418-hy8xmtiq 127 50 implement implement VB cord-011418-hy8xmtiq 127 51 a a DT cord-011418-hy8xmtiq 127 52 unit unit NN cord-011418-hy8xmtiq 127 53 - - HYPH cord-011418-hy8xmtiq 127 54 wide wide JJ cord-011418-hy8xmtiq 127 55 protocol protocol NN cord-011418-hy8xmtiq 127 56 . . . cord-011418-hy8xmtiq 128 1 Protocols protocol NNS cord-011418-hy8xmtiq 128 2 should should MD cord-011418-hy8xmtiq 128 3 take take VB cord-011418-hy8xmtiq 128 4 into into IN cord-011418-hy8xmtiq 128 5 consideration consideration NN cord-011418-hy8xmtiq 128 6 unit unit NN cord-011418-hy8xmtiq 128 7 - - HYPH cord-011418-hy8xmtiq 128 8 and and CC cord-011418-hy8xmtiq 128 9 hospital hospital NN cord-011418-hy8xmtiq 128 10 - - HYPH cord-011418-hy8xmtiq 128 11 specific specific JJ cord-011418-hy8xmtiq 128 12 needs need NNS cord-011418-hy8xmtiq 128 13 and and CC cord-011418-hy8xmtiq 128 14 resources resource NNS cord-011418-hy8xmtiq 128 15 , , , cord-011418-hy8xmtiq 128 16 and and CC cord-011418-hy8xmtiq 128 17 always always RB cord-011418-hy8xmtiq 128 18 make make VB cord-011418-hy8xmtiq 128 19 patient patient JJ cord-011418-hy8xmtiq 128 20 safety safety NN cord-011418-hy8xmtiq 128 21 a a DT cord-011418-hy8xmtiq 128 22 priority priority NN cord-011418-hy8xmtiq 128 23 . . . cord-011418-hy8xmtiq 129 1 Engage engage VB cord-011418-hy8xmtiq 129 2 bedside bedside NN cord-011418-hy8xmtiq 129 3 staff staff NN cord-011418-hy8xmtiq 129 4 with with IN cord-011418-hy8xmtiq 129 5 education education NN cord-011418-hy8xmtiq 129 6 , , , cord-011418-hy8xmtiq 129 7 hands hand NNS cord-011418-hy8xmtiq 129 8 - - HYPH cord-011418-hy8xmtiq 129 9 on on RP cord-011418-hy8xmtiq 129 10 experience experience NN cord-011418-hy8xmtiq 129 11 , , , cord-011418-hy8xmtiq 129 12 and and CC cord-011418-hy8xmtiq 129 13 success success NN cord-011418-hy8xmtiq 129 14 stories story NNS cord-011418-hy8xmtiq 129 15 to to TO cord-011418-hy8xmtiq 129 16 encourage encourage VB cord-011418-hy8xmtiq 129 17 protocol protocol NN cord-011418-hy8xmtiq 129 18 adherence adherence NN cord-011418-hy8xmtiq 129 19 . . . cord-011418-hy8xmtiq 130 1 Patient patient NN cord-011418-hy8xmtiq 130 2 - - : cord-011418-hy8xmtiq 130 3 and and CC cord-011418-hy8xmtiq 130 4 family family NN cord-011418-hy8xmtiq 130 5 - - HYPH cord-011418-hy8xmtiq 130 6 centered center VBN cord-011418-hy8xmtiq 130 7 care care NN cord-011418-hy8xmtiq 130 8 ( ( -LRB- cord-011418-hy8xmtiq 130 9 PFCC PFCC NNP cord-011418-hy8xmtiq 130 10 ) ) -RRB- cord-011418-hy8xmtiq 130 11 is be VBZ cord-011418-hy8xmtiq 130 12 not not RB cord-011418-hy8xmtiq 130 13 a a DT cord-011418-hy8xmtiq 130 14 novel novel JJ cord-011418-hy8xmtiq 130 15 concept concept NN cord-011418-hy8xmtiq 130 16 to to IN cord-011418-hy8xmtiq 130 17 pediatricians pediatrician NNS cord-011418-hy8xmtiq 130 18 , , , cord-011418-hy8xmtiq 130 19 as as IN cord-011418-hy8xmtiq 130 20 it -PRON- PRP cord-011418-hy8xmtiq 130 21 is be VBZ cord-011418-hy8xmtiq 130 22 a a DT cord-011418-hy8xmtiq 130 23 core core NN cord-011418-hy8xmtiq 130 24 value value NN cord-011418-hy8xmtiq 130 25 in in IN cord-011418-hy8xmtiq 130 26 the the DT cord-011418-hy8xmtiq 130 27 field field NN cord-011418-hy8xmtiq 130 28 of of IN cord-011418-hy8xmtiq 130 29 pediatrics pediatric NNS cord-011418-hy8xmtiq 130 30 given give VBN cord-011418-hy8xmtiq 130 31 the the DT cord-011418-hy8xmtiq 130 32 importance importance NN cord-011418-hy8xmtiq 130 33 of of IN cord-011418-hy8xmtiq 130 34 family family NN cord-011418-hy8xmtiq 130 35 engagement engagement NN cord-011418-hy8xmtiq 130 36 to to IN cord-011418-hy8xmtiq 130 37 the the DT cord-011418-hy8xmtiq 130 38 successful successful JJ cord-011418-hy8xmtiq 130 39 care care NN cord-011418-hy8xmtiq 130 40 of of IN cord-011418-hy8xmtiq 130 41 children child NNS cord-011418-hy8xmtiq 130 42 . . . cord-011418-hy8xmtiq 131 1 PFCC PFCC NNP cord-011418-hy8xmtiq 131 2 is be VBZ cord-011418-hy8xmtiq 131 3 rooted root VBN cord-011418-hy8xmtiq 131 4 in in IN cord-011418-hy8xmtiq 131 5 the the DT cord-011418-hy8xmtiq 131 6 understanding understanding NN cord-011418-hy8xmtiq 131 7 that that IN cord-011418-hy8xmtiq 131 8 involving involve VBG cord-011418-hy8xmtiq 131 9 patients patient NNS cord-011418-hy8xmtiq 131 10 and and CC cord-011418-hy8xmtiq 131 11 families family NNS cord-011418-hy8xmtiq 131 12 in in IN cord-011418-hy8xmtiq 131 13 their -PRON- PRP$ cord-011418-hy8xmtiq 131 14 own own JJ cord-011418-hy8xmtiq 131 15 care care NN cord-011418-hy8xmtiq 131 16 or or CC cord-011418-hy8xmtiq 131 17 their -PRON- PRP$ cord-011418-hy8xmtiq 131 18 loved love VBN cord-011418-hy8xmtiq 131 19 one one NN cord-011418-hy8xmtiq 131 20 's 's POS cord-011418-hy8xmtiq 131 21 care care NN cord-011418-hy8xmtiq 131 22 is be VBZ cord-011418-hy8xmtiq 131 23 a a DT cord-011418-hy8xmtiq 131 24 mutually mutually RB cord-011418-hy8xmtiq 131 25 beneficial beneficial JJ cord-011418-hy8xmtiq 131 26 experience experience NN cord-011418-hy8xmtiq 131 27 that that WDT cord-011418-hy8xmtiq 131 28 will will MD cord-011418-hy8xmtiq 131 29 result result VB cord-011418-hy8xmtiq 131 30 in in IN cord-011418-hy8xmtiq 131 31 improved improved JJ cord-011418-hy8xmtiq 131 32 patient patient JJ cord-011418-hy8xmtiq 131 33 satisfaction satisfaction NN cord-011418-hy8xmtiq 131 34 , , , cord-011418-hy8xmtiq 131 35 decreased decrease VBD cord-011418-hy8xmtiq 131 36 patient patient JJ cord-011418-hy8xmtiq 131 37 anxiety anxiety NN cord-011418-hy8xmtiq 131 38 , , , cord-011418-hy8xmtiq 131 39 confusion confusion NN cord-011418-hy8xmtiq 131 40 , , , cord-011418-hy8xmtiq 131 41 and and CC cord-011418-hy8xmtiq 131 42 agitation agitation NN cord-011418-hy8xmtiq 131 43 , , , cord-011418-hy8xmtiq 131 44 and and CC cord-011418-hy8xmtiq 131 45 potentially potentially RB cord-011418-hy8xmtiq 131 46 higher high JJR cord-011418-hy8xmtiq 131 47 quality quality NN cord-011418-hy8xmtiq 131 48 care care NN cord-011418-hy8xmtiq 131 49 and and CC cord-011418-hy8xmtiq 131 50 safer safe JJR cord-011418-hy8xmtiq 131 51 care care VB cord-011418-hy8xmtiq 131 52 [ [ -LRB- cord-011418-hy8xmtiq 131 53 87 87 CD cord-011418-hy8xmtiq 131 54 ] ] -RRB- cord-011418-hy8xmtiq 132 1 [ [ -LRB- cord-011418-hy8xmtiq 132 2 88 88 CD cord-011418-hy8xmtiq 132 3 ] ] -RRB- cord-011418-hy8xmtiq 132 4 [ [ -LRB- cord-011418-hy8xmtiq 132 5 89 89 CD cord-011418-hy8xmtiq 132 6 ] ] -RRB- cord-011418-hy8xmtiq 132 7 . . . cord-011418-hy8xmtiq 133 1 The the DT cord-011418-hy8xmtiq 133 2 core core NN cord-011418-hy8xmtiq 133 3 PFCC PFCC NNP cord-011418-hy8xmtiq 133 4 values value NNS cord-011418-hy8xmtiq 133 5 in in IN cord-011418-hy8xmtiq 133 6 the the DT cord-011418-hy8xmtiq 133 7 ICU ICU NNP cord-011418-hy8xmtiq 133 8 liberation liberation NN cord-011418-hy8xmtiq 133 9 bundle bundle NN cord-011418-hy8xmtiq 133 10 are be VBP cord-011418-hy8xmtiq 133 11 keeping keep VBG cord-011418-hy8xmtiq 133 12 patients patient NNS cord-011418-hy8xmtiq 133 13 and and CC cord-011418-hy8xmtiq 133 14 families family NNS cord-011418-hy8xmtiq 133 15 informed inform VBN cord-011418-hy8xmtiq 133 16 , , , cord-011418-hy8xmtiq 133 17 actively actively RB cord-011418-hy8xmtiq 133 18 involving involve VBG cord-011418-hy8xmtiq 133 19 patients patient NNS cord-011418-hy8xmtiq 133 20 and and CC cord-011418-hy8xmtiq 133 21 families family NNS cord-011418-hy8xmtiq 133 22 in in IN cord-011418-hy8xmtiq 133 23 decision decision NN cord-011418-hy8xmtiq 133 24 - - HYPH cord-011418-hy8xmtiq 133 25 making making NN cord-011418-hy8xmtiq 133 26 , , , cord-011418-hy8xmtiq 133 27 actively actively RB cord-011418-hy8xmtiq 133 28 involving involve VBG cord-011418-hy8xmtiq 133 29 patients patient NNS cord-011418-hy8xmtiq 133 30 and and CC cord-011418-hy8xmtiq 133 31 families family NNS cord-011418-hy8xmtiq 133 32 in in IN cord-011418-hy8xmtiq 133 33 self self NN cord-011418-hy8xmtiq 133 34 - - HYPH cord-011418-hy8xmtiq 133 35 management management NN cord-011418-hy8xmtiq 133 36 , , , cord-011418-hy8xmtiq 133 37 providing provide VBG cord-011418-hy8xmtiq 133 38 both both DT cord-011418-hy8xmtiq 133 39 physical physical JJ cord-011418-hy8xmtiq 133 40 comfort comfort NN cord-011418-hy8xmtiq 133 41 and and CC cord-011418-hy8xmtiq 133 42 emotional emotional JJ cord-011418-hy8xmtiq 133 43 support support NN cord-011418-hy8xmtiq 133 44 to to IN cord-011418-hy8xmtiq 133 45 patient patient NN cord-011418-hy8xmtiq 133 46 and and CC cord-011418-hy8xmtiq 133 47 families family NNS cord-011418-hy8xmtiq 133 48 , , , cord-011418-hy8xmtiq 133 49 and and CC cord-011418-hy8xmtiq 133 50 maintaining maintain VBG cord-011418-hy8xmtiq 133 51 a a DT cord-011418-hy8xmtiq 133 52 clear clear JJ cord-011418-hy8xmtiq 133 53 understanding understanding NN cord-011418-hy8xmtiq 133 54 of of IN cord-011418-hy8xmtiq 133 55 patients patient NNS cord-011418-hy8xmtiq 133 56 ' ' POS cord-011418-hy8xmtiq 133 57 concepts concept NNS cord-011418-hy8xmtiq 133 58 of of IN cord-011418-hy8xmtiq 133 59 illness illness NN cord-011418-hy8xmtiq 133 60 and and CC cord-011418-hy8xmtiq 133 61 cultural cultural JJ cord-011418-hy8xmtiq 133 62 beliefs belief NNS cord-011418-hy8xmtiq 133 63 [ [ -LRB- cord-011418-hy8xmtiq 133 64 90 90 CD cord-011418-hy8xmtiq 133 65 ] ] -RRB- cord-011418-hy8xmtiq 133 66 . . . cord-011418-hy8xmtiq 134 1 Tips tip NNS cord-011418-hy8xmtiq 134 2 for for IN cord-011418-hy8xmtiq 134 3 Implementation Implementation NNP cord-011418-hy8xmtiq 134 4 Form form VB cord-011418-hy8xmtiq 134 5 a a DT cord-011418-hy8xmtiq 134 6 patient patient NN cord-011418-hy8xmtiq 134 7 and and CC cord-011418-hy8xmtiq 134 8 family family NN cord-011418-hy8xmtiq 134 9 counsel counsel NN cord-011418-hy8xmtiq 134 10 to to TO cord-011418-hy8xmtiq 134 11 help help VB cord-011418-hy8xmtiq 134 12 identify identify VB cord-011418-hy8xmtiq 134 13 areas area NNS cord-011418-hy8xmtiq 134 14 for for IN cord-011418-hy8xmtiq 134 15 improvement improvement NN cord-011418-hy8xmtiq 134 16 and and CC cord-011418-hy8xmtiq 134 17 guide guide NN cord-011418-hy8xmtiq 134 18 change change NN cord-011418-hy8xmtiq 134 19 . . . cord-011418-hy8xmtiq 135 1 Consider consider VB cord-011418-hy8xmtiq 135 2 a a DT cord-011418-hy8xmtiq 135 3 family family NN cord-011418-hy8xmtiq 135 4 survey survey NN cord-011418-hy8xmtiq 135 5 to to TO cord-011418-hy8xmtiq 135 6 understand understand VB cord-011418-hy8xmtiq 135 7 baseline baseline JJ cord-011418-hy8xmtiq 135 8 family family NN cord-011418-hy8xmtiq 135 9 engagement engagement NN cord-011418-hy8xmtiq 135 10 in in IN cord-011418-hy8xmtiq 135 11 your -PRON- PRP$ cord-011418-hy8xmtiq 135 12 PICU PICU NNP cord-011418-hy8xmtiq 135 13 . . . cord-011418-hy8xmtiq 136 1 Common common JJ cord-011418-hy8xmtiq 136 2 ways way NNS cord-011418-hy8xmtiq 136 3 to to TO cord-011418-hy8xmtiq 136 4 institute institute VB cord-011418-hy8xmtiq 136 5 PFCC PFCC NNP cord-011418-hy8xmtiq 136 6 include include VBP cord-011418-hy8xmtiq 136 7 open open JJ cord-011418-hy8xmtiq 136 8 visitation visitation NN cord-011418-hy8xmtiq 136 9 policies policy NNS cord-011418-hy8xmtiq 136 10 , , , cord-011418-hy8xmtiq 136 11 family family NN cord-011418-hy8xmtiq 136 12 - - HYPH cord-011418-hy8xmtiq 136 13 centered center VBN cord-011418-hy8xmtiq 136 14 rounds round NNS cord-011418-hy8xmtiq 136 15 , , , cord-011418-hy8xmtiq 136 16 allowing allow VBG cord-011418-hy8xmtiq 136 17 family family NN cord-011418-hy8xmtiq 136 18 presence presence NN cord-011418-hy8xmtiq 136 19 during during IN cord-011418-hy8xmtiq 136 20 codes code NNS cord-011418-hy8xmtiq 136 21 , , , cord-011418-hy8xmtiq 136 22 providing provide VBG cord-011418-hy8xmtiq 136 23 education education NN cord-011418-hy8xmtiq 136 24 to to IN cord-011418-hy8xmtiq 136 25 families family NNS cord-011418-hy8xmtiq 136 26 on on IN cord-011418-hy8xmtiq 136 27 how how WRB cord-011418-hy8xmtiq 136 28 they -PRON- PRP cord-011418-hy8xmtiq 136 29 can can MD cord-011418-hy8xmtiq 136 30 participate participate VB cord-011418-hy8xmtiq 136 31 in in IN cord-011418-hy8xmtiq 136 32 care care NN cord-011418-hy8xmtiq 136 33 , , , cord-011418-hy8xmtiq 136 34 encouraging encourage VBG cord-011418-hy8xmtiq 136 35 families family NNS cord-011418-hy8xmtiq 136 36 to to TO cord-011418-hy8xmtiq 136 37 be be VB cord-011418-hy8xmtiq 136 38 part part NN cord-011418-hy8xmtiq 136 39 of of IN cord-011418-hy8xmtiq 136 40 your -PRON- PRP$ cord-011418-hy8xmtiq 136 41 unit unit NN cord-011418-hy8xmtiq 136 42 's 's POS cord-011418-hy8xmtiq 136 43 safety safety NN cord-011418-hy8xmtiq 136 44 culture culture NN cord-011418-hy8xmtiq 136 45 , , , cord-011418-hy8xmtiq 136 46 providing provide VBG cord-011418-hy8xmtiq 136 47 ICU ICU NNP cord-011418-hy8xmtiq 136 48 diaries diary NNS cord-011418-hy8xmtiq 136 49 , , , cord-011418-hy8xmtiq 136 50 and and CC cord-011418-hy8xmtiq 136 51 practicing practice VBG cord-011418-hy8xmtiq 136 52 shared share VBN cord-011418-hy8xmtiq 136 53 decision decision NN cord-011418-hy8xmtiq 136 54 - - HYPH cord-011418-hy8xmtiq 136 55 making making NN cord-011418-hy8xmtiq 136 56 to to TO cord-011418-hy8xmtiq 136 57 create create VB cord-011418-hy8xmtiq 136 58 a a DT cord-011418-hy8xmtiq 136 59 partnership partnership NN cord-011418-hy8xmtiq 136 60 between between IN cord-011418-hy8xmtiq 136 61 the the DT cord-011418-hy8xmtiq 136 62 ICU ICU NNP cord-011418-hy8xmtiq 136 63 team team NN cord-011418-hy8xmtiq 136 64 and and CC cord-011418-hy8xmtiq 136 65 families family NNS cord-011418-hy8xmtiq 136 66 . . . cord-011418-hy8xmtiq 137 1 Implementation implementation NN cord-011418-hy8xmtiq 137 2 of of IN cord-011418-hy8xmtiq 137 3 the the DT cord-011418-hy8xmtiq 137 4 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 137 5 bundle bundle NN cord-011418-hy8xmtiq 137 6 can can MD cord-011418-hy8xmtiq 137 7 be be VB cord-011418-hy8xmtiq 137 8 daunting daunting JJ cord-011418-hy8xmtiq 137 9 since since IN cord-011418-hy8xmtiq 137 10 it -PRON- PRP cord-011418-hy8xmtiq 137 11 requires require VBZ cord-011418-hy8xmtiq 137 12 a a DT cord-011418-hy8xmtiq 137 13 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 137 14 collaborative collaborative JJ cord-011418-hy8xmtiq 137 15 approach approach NN cord-011418-hy8xmtiq 137 16 and and CC cord-011418-hy8xmtiq 137 17 a a DT cord-011418-hy8xmtiq 137 18 real real JJ cord-011418-hy8xmtiq 137 19 culture culture NN cord-011418-hy8xmtiq 137 20 change change NN cord-011418-hy8xmtiq 137 21 . . . cord-011418-hy8xmtiq 138 1 A a DT cord-011418-hy8xmtiq 138 2 recent recent JJ cord-011418-hy8xmtiq 138 3 review review NN cord-011418-hy8xmtiq 138 4 on on IN cord-011418-hy8xmtiq 138 5 the the DT cord-011418-hy8xmtiq 138 6 existing exist VBG cord-011418-hy8xmtiq 138 7 barriers barrier NNS cord-011418-hy8xmtiq 138 8 to to IN cord-011418-hy8xmtiq 138 9 ABCDE abcde NN cord-011418-hy8xmtiq 138 10 bundle bundle NN cord-011418-hy8xmtiq 138 11 implementation implementation NN cord-011418-hy8xmtiq 138 12 in in IN cord-011418-hy8xmtiq 138 13 adult adult NN cord-011418-hy8xmtiq 138 14 ICU ICU NNP cord-011418-hy8xmtiq 138 15 identified identify VBD cord-011418-hy8xmtiq 138 16 four four CD cord-011418-hy8xmtiq 138 17 distinct distinct JJ cord-011418-hy8xmtiq 138 18 domains domain NNS cord-011418-hy8xmtiq 138 19 : : : cord-011418-hy8xmtiq 138 20 ( ( -LRB- cord-011418-hy8xmtiq 138 21 1 1 LS cord-011418-hy8xmtiq 138 22 ) ) -RRB- cord-011418-hy8xmtiq 138 23 patient patient NN cord-011418-hy8xmtiq 138 24 - - HYPH cord-011418-hy8xmtiq 138 25 related relate VBN cord-011418-hy8xmtiq 138 26 , , , cord-011418-hy8xmtiq 138 27 ( ( -LRB- cord-011418-hy8xmtiq 138 28 2 2 LS cord-011418-hy8xmtiq 138 29 ) ) -RRB- cord-011418-hy8xmtiq 138 30 clinician clinician NN cord-011418-hy8xmtiq 138 31 - - HYPH cord-011418-hy8xmtiq 138 32 related relate VBN cord-011418-hy8xmtiq 138 33 , , , cord-011418-hy8xmtiq 138 34 ( ( -LRB- cord-011418-hy8xmtiq 138 35 3 3 CD cord-011418-hy8xmtiq 138 36 ) ) -RRB- cord-011418-hy8xmtiq 138 37 protocol protocol NN cord-011418-hy8xmtiq 138 38 - - HYPH cord-011418-hy8xmtiq 138 39 related relate VBN cord-011418-hy8xmtiq 138 40 , , , cord-011418-hy8xmtiq 138 41 and and CC cord-011418-hy8xmtiq 138 42 ( ( -LRB- cord-011418-hy8xmtiq 138 43 4 4 LS cord-011418-hy8xmtiq 138 44 ) ) -RRB- cord-011418-hy8xmtiq 139 1 ICU ICU NNP cord-011418-hy8xmtiq 139 2 contextual contextual JJ cord-011418-hy8xmtiq 139 3 barriers barrier NNS cord-011418-hy8xmtiq 139 4 [ [ -LRB- cord-011418-hy8xmtiq 139 5 91 91 CD cord-011418-hy8xmtiq 139 6 ] ] -RRB- cord-011418-hy8xmtiq 139 7 . . . cord-011418-hy8xmtiq 140 1 These these DT cord-011418-hy8xmtiq 140 2 domains domain NNS cord-011418-hy8xmtiq 140 3 are be VBP cord-011418-hy8xmtiq 140 4 consistent consistent JJ cord-011418-hy8xmtiq 140 5 with with IN cord-011418-hy8xmtiq 140 6 domains domain NNS cord-011418-hy8xmtiq 140 7 of of IN cord-011418-hy8xmtiq 140 8 the the DT cord-011418-hy8xmtiq 140 9 Consolidated Consolidated NNP cord-011418-hy8xmtiq 140 10 Framework Framework NNP cord-011418-hy8xmtiq 140 11 for for IN cord-011418-hy8xmtiq 140 12 Implementation Implementation NNP cord-011418-hy8xmtiq 140 13 Research Research NNP cord-011418-hy8xmtiq 140 14 ( ( -LRB- cord-011418-hy8xmtiq 140 15 CFIR CFIR NNP cord-011418-hy8xmtiq 140 16 ) ) -RRB- cord-011418-hy8xmtiq 140 17 , , , cord-011418-hy8xmtiq 140 18 a a DT cord-011418-hy8xmtiq 140 19 widely widely RB cord-011418-hy8xmtiq 140 20 - - HYPH cord-011418-hy8xmtiq 140 21 used use VBN cord-011418-hy8xmtiq 140 22 framework framework NN cord-011418-hy8xmtiq 140 23 in in IN cord-011418-hy8xmtiq 140 24 implementation implementation NN cord-011418-hy8xmtiq 140 25 science science NN cord-011418-hy8xmtiq 140 26 [ [ -LRB- cord-011418-hy8xmtiq 140 27 92 92 CD cord-011418-hy8xmtiq 140 28 ] ] -RRB- cord-011418-hy8xmtiq 140 29 . . . cord-011418-hy8xmtiq 141 1 Each each DT cord-011418-hy8xmtiq 141 2 PICU PICU NNP cord-011418-hy8xmtiq 141 3 will will MD cord-011418-hy8xmtiq 141 4 likely likely RB cord-011418-hy8xmtiq 141 5 face face VB cord-011418-hy8xmtiq 141 6 different different JJ cord-011418-hy8xmtiq 141 7 barriers barrier NNS cord-011418-hy8xmtiq 141 8 within within IN cord-011418-hy8xmtiq 141 9 each each DT cord-011418-hy8xmtiq 141 10 domain domain NN cord-011418-hy8xmtiq 141 11 , , , cord-011418-hy8xmtiq 141 12 and and CC cord-011418-hy8xmtiq 141 13 the the DT cord-011418-hy8xmtiq 141 14 first first JJ cord-011418-hy8xmtiq 141 15 step step NN cord-011418-hy8xmtiq 141 16 to to IN cord-011418-hy8xmtiq 141 17 implementation implementation NN cord-011418-hy8xmtiq 141 18 should should MD cord-011418-hy8xmtiq 141 19 be be VB cord-011418-hy8xmtiq 141 20 to to TO cord-011418-hy8xmtiq 141 21 identify identify VB cord-011418-hy8xmtiq 141 22 our -PRON- PRP$ cord-011418-hy8xmtiq 141 23 own own JJ cord-011418-hy8xmtiq 141 24 unit unit NN cord-011418-hy8xmtiq 141 25 's 's POS cord-011418-hy8xmtiq 141 26 barriers barrier NNS cord-011418-hy8xmtiq 141 27 . . . cord-011418-hy8xmtiq 142 1 One one CD cord-011418-hy8xmtiq 142 2 of of IN cord-011418-hy8xmtiq 142 3 the the DT cord-011418-hy8xmtiq 142 4 most most RBS cord-011418-hy8xmtiq 142 5 common common JJ cord-011418-hy8xmtiq 142 6 hurdles hurdle NNS cord-011418-hy8xmtiq 142 7 to to IN cord-011418-hy8xmtiq 142 8 protocol protocol NN cord-011418-hy8xmtiq 142 9 implementation implementation NN cord-011418-hy8xmtiq 142 10 is be VBZ cord-011418-hy8xmtiq 142 11 provider provider NN cord-011418-hy8xmtiq 142 12 buy buy NN cord-011418-hy8xmtiq 142 13 - - HYPH cord-011418-hy8xmtiq 142 14 in in NN cord-011418-hy8xmtiq 142 15 . . . cord-011418-hy8xmtiq 143 1 Bedside bedside NN cord-011418-hy8xmtiq 143 2 providers provider NNS cord-011418-hy8xmtiq 143 3 may may MD cord-011418-hy8xmtiq 143 4 have have VB cord-011418-hy8xmtiq 143 5 concerns concern NNS cord-011418-hy8xmtiq 143 6 about about IN cord-011418-hy8xmtiq 143 7 patient patient JJ cord-011418-hy8xmtiq 143 8 safety safety NN cord-011418-hy8xmtiq 143 9 ( ( -LRB- cord-011418-hy8xmtiq 143 10 especially especially RB cord-011418-hy8xmtiq 143 11 for for IN cord-011418-hy8xmtiq 143 12 early early JJ cord-011418-hy8xmtiq 143 13 mobility mobility NN cord-011418-hy8xmtiq 143 14 and and CC cord-011418-hy8xmtiq 143 15 the the DT cord-011418-hy8xmtiq 143 16 use use NN cord-011418-hy8xmtiq 143 17 of of IN cord-011418-hy8xmtiq 143 18 an an DT cord-011418-hy8xmtiq 143 19 analgosedation analgosedation NN cord-011418-hy8xmtiq 143 20 model model NN cord-011418-hy8xmtiq 143 21 ) ) -RRB- cord-011418-hy8xmtiq 143 22 and and CC cord-011418-hy8xmtiq 143 23 may may MD cord-011418-hy8xmtiq 143 24 think think VB cord-011418-hy8xmtiq 143 25 that that IN cord-011418-hy8xmtiq 143 26 the the DT cord-011418-hy8xmtiq 143 27 risk risk NN cord-011418-hy8xmtiq 143 28 it -PRON- PRP cord-011418-hy8xmtiq 143 29 poses pose VBZ cord-011418-hy8xmtiq 143 30 outweighs outweighs NN cord-011418-hy8xmtiq 143 31 potential potential JJ cord-011418-hy8xmtiq 143 32 benefits benefit NNS cord-011418-hy8xmtiq 143 33 . . . cord-011418-hy8xmtiq 144 1 With with IN cord-011418-hy8xmtiq 144 2 effective effective JJ cord-011418-hy8xmtiq 144 3 education education NN cord-011418-hy8xmtiq 144 4 on on IN cord-011418-hy8xmtiq 144 5 the the DT cord-011418-hy8xmtiq 144 6 safety safety NN cord-011418-hy8xmtiq 144 7 and and CC cord-011418-hy8xmtiq 144 8 feasibility feasibility NN cord-011418-hy8xmtiq 144 9 of of IN cord-011418-hy8xmtiq 144 10 bundle bundle NN cord-011418-hy8xmtiq 144 11 implementation implementation NN cord-011418-hy8xmtiq 144 12 [ [ -LRB- cord-011418-hy8xmtiq 144 13 79 79 CD cord-011418-hy8xmtiq 144 14 , , , cord-011418-hy8xmtiq 144 15 81 81 CD cord-011418-hy8xmtiq 144 16 ] ] -RRB- cord-011418-hy8xmtiq 144 17 and and CC cord-011418-hy8xmtiq 144 18 ongoing ongoing JJ cord-011418-hy8xmtiq 144 19 feedback feedback NN cord-011418-hy8xmtiq 144 20 to to IN cord-011418-hy8xmtiq 144 21 providers provider NNS cord-011418-hy8xmtiq 144 22 with with IN cord-011418-hy8xmtiq 144 23 up up IN cord-011418-hy8xmtiq 144 24 to to IN cord-011418-hy8xmtiq 144 25 date date NN cord-011418-hy8xmtiq 144 26 data datum NNS cord-011418-hy8xmtiq 144 27 on on IN cord-011418-hy8xmtiq 144 28 how how WRB cord-011418-hy8xmtiq 144 29 usage usage NN cord-011418-hy8xmtiq 144 30 of of IN cord-011418-hy8xmtiq 144 31 the the DT cord-011418-hy8xmtiq 144 32 bundle bundle NN cord-011418-hy8xmtiq 144 33 is be VBZ cord-011418-hy8xmtiq 144 34 helping help VBG cord-011418-hy8xmtiq 144 35 their -PRON- PRP$ cord-011418-hy8xmtiq 144 36 patients patient NNS cord-011418-hy8xmtiq 144 37 , , , cord-011418-hy8xmtiq 144 38 providers provider NNS cord-011418-hy8xmtiq 144 39 can can MD cord-011418-hy8xmtiq 144 40 feel feel VB cord-011418-hy8xmtiq 144 41 empowered empowered JJ cord-011418-hy8xmtiq 144 42 and and CC cord-011418-hy8xmtiq 144 43 motivated motivate VBN cord-011418-hy8xmtiq 144 44 to to TO cord-011418-hy8xmtiq 144 45 lead lead VB cord-011418-hy8xmtiq 144 46 bundle bundle NN cord-011418-hy8xmtiq 144 47 reliability reliability NN cord-011418-hy8xmtiq 144 48 performance performance NN cord-011418-hy8xmtiq 144 49 . . . cord-011418-hy8xmtiq 145 1 Involving involve VBG cord-011418-hy8xmtiq 145 2 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 145 3 bedside bedside NN cord-011418-hy8xmtiq 145 4 providers provider NNS cord-011418-hy8xmtiq 145 5 and and CC cord-011418-hy8xmtiq 145 6 other other JJ cord-011418-hy8xmtiq 145 7 key key JJ cord-011418-hy8xmtiq 145 8 stakeholders stakeholder NNS cord-011418-hy8xmtiq 145 9 early early RB cord-011418-hy8xmtiq 145 10 on on RB cord-011418-hy8xmtiq 145 11 during during IN cord-011418-hy8xmtiq 145 12 protocol protocol NN cord-011418-hy8xmtiq 145 13 design design NN cord-011418-hy8xmtiq 145 14 is be VBZ cord-011418-hy8xmtiq 145 15 also also RB cord-011418-hy8xmtiq 145 16 essential essential JJ cord-011418-hy8xmtiq 145 17 to to TO cord-011418-hy8xmtiq 145 18 ensure ensure VB cord-011418-hy8xmtiq 145 19 protocol protocol NN cord-011418-hy8xmtiq 145 20 feasibility feasibility NN cord-011418-hy8xmtiq 145 21 and and CC cord-011418-hy8xmtiq 145 22 will will MD cord-011418-hy8xmtiq 145 23 help help VB cord-011418-hy8xmtiq 145 24 buy buy VB cord-011418-hy8xmtiq 145 25 - - HYPH cord-011418-hy8xmtiq 145 26 in in NN cord-011418-hy8xmtiq 145 27 . . . cord-011418-hy8xmtiq 146 1 Another another DT cord-011418-hy8xmtiq 146 2 frequently frequently RB cord-011418-hy8xmtiq 146 3 encountered encounter VBD cord-011418-hy8xmtiq 146 4 barrier barrier NN cord-011418-hy8xmtiq 146 5 to to IN cord-011418-hy8xmtiq 146 6 protocol protocol NN cord-011418-hy8xmtiq 146 7 implementation implementation NN cord-011418-hy8xmtiq 146 8 is be VBZ cord-011418-hy8xmtiq 146 9 resource resource NN cord-011418-hy8xmtiq 146 10 limitations limitation NNS cord-011418-hy8xmtiq 146 11 , , , cord-011418-hy8xmtiq 146 12 especially especially RB cord-011418-hy8xmtiq 146 13 the the DT cord-011418-hy8xmtiq 146 14 availability availability NN cord-011418-hy8xmtiq 146 15 of of IN cord-011418-hy8xmtiq 146 16 personnel personnel NNS cord-011418-hy8xmtiq 146 17 such such JJ cord-011418-hy8xmtiq 146 18 as as IN cord-011418-hy8xmtiq 146 19 physical physical JJ cord-011418-hy8xmtiq 146 20 and and CC cord-011418-hy8xmtiq 146 21 respiratory respiratory JJ cord-011418-hy8xmtiq 146 22 therapists therapist NNS cord-011418-hy8xmtiq 146 23 , , , cord-011418-hy8xmtiq 146 24 and and CC cord-011418-hy8xmtiq 146 25 equipment equipment NN cord-011418-hy8xmtiq 146 26 . . . cord-011418-hy8xmtiq 147 1 Support support NN cord-011418-hy8xmtiq 147 2 and and CC cord-011418-hy8xmtiq 147 3 engagement engagement NN cord-011418-hy8xmtiq 147 4 of of IN cord-011418-hy8xmtiq 147 5 senior senior JJ cord-011418-hy8xmtiq 147 6 health health NN cord-011418-hy8xmtiq 147 7 care care NN cord-011418-hy8xmtiq 147 8 executive executive NN cord-011418-hy8xmtiq 147 9 can can MD cord-011418-hy8xmtiq 147 10 help help VB cord-011418-hy8xmtiq 147 11 secure secure VB cord-011418-hy8xmtiq 147 12 and and CC cord-011418-hy8xmtiq 147 13 allocate allocate VB cord-011418-hy8xmtiq 147 14 the the DT cord-011418-hy8xmtiq 147 15 appropriate appropriate JJ cord-011418-hy8xmtiq 147 16 resources resource NNS cord-011418-hy8xmtiq 147 17 . . . cord-011418-hy8xmtiq 148 1 The the DT cord-011418-hy8xmtiq 148 2 support support NN cord-011418-hy8xmtiq 148 3 of of IN cord-011418-hy8xmtiq 148 4 these these DT cord-011418-hy8xmtiq 148 5 groups group NNS cord-011418-hy8xmtiq 148 6 is be VBZ cord-011418-hy8xmtiq 148 7 vital vital JJ cord-011418-hy8xmtiq 148 8 to to IN cord-011418-hy8xmtiq 148 9 the the DT cord-011418-hy8xmtiq 148 10 success success NN cord-011418-hy8xmtiq 148 11 of of IN cord-011418-hy8xmtiq 148 12 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 148 13 bundle bundle NN cord-011418-hy8xmtiq 148 14 implementation implementation NN cord-011418-hy8xmtiq 148 15 and and CC cord-011418-hy8xmtiq 148 16 function function NN cord-011418-hy8xmtiq 148 17 , , , cord-011418-hy8xmtiq 148 18 as as IN cord-011418-hy8xmtiq 148 19 they -PRON- PRP cord-011418-hy8xmtiq 148 20 can can MD cord-011418-hy8xmtiq 148 21 play play VB cord-011418-hy8xmtiq 148 22 an an DT cord-011418-hy8xmtiq 148 23 important important JJ cord-011418-hy8xmtiq 148 24 role role NN cord-011418-hy8xmtiq 148 25 in in IN cord-011418-hy8xmtiq 148 26 motivating motivate VBG cord-011418-hy8xmtiq 148 27 teams team NNS cord-011418-hy8xmtiq 148 28 , , , cord-011418-hy8xmtiq 148 29 helping help VBG cord-011418-hy8xmtiq 148 30 to to TO cord-011418-hy8xmtiq 148 31 solve solve VB cord-011418-hy8xmtiq 148 32 complex complex JJ cord-011418-hy8xmtiq 148 33 problems problem NNS cord-011418-hy8xmtiq 148 34 involving involve VBG cord-011418-hy8xmtiq 148 35 culture culture NN cord-011418-hy8xmtiq 148 36 change change NN cord-011418-hy8xmtiq 148 37 within within IN cord-011418-hy8xmtiq 148 38 the the DT cord-011418-hy8xmtiq 148 39 hospital hospital NN cord-011418-hy8xmtiq 148 40 and and CC cord-011418-hy8xmtiq 148 41 ICU ICU NNP cord-011418-hy8xmtiq 148 42 environment environment NN cord-011418-hy8xmtiq 148 43 [ [ -LRB- cord-011418-hy8xmtiq 148 44 93 93 CD cord-011418-hy8xmtiq 148 45 ] ] -RRB- cord-011418-hy8xmtiq 148 46 . . . cord-011418-hy8xmtiq 149 1 A a DT cord-011418-hy8xmtiq 149 2 summary summary NN cord-011418-hy8xmtiq 149 3 of of IN cord-011418-hy8xmtiq 149 4 these these DT cord-011418-hy8xmtiq 149 5 and and CC cord-011418-hy8xmtiq 149 6 other other JJ cord-011418-hy8xmtiq 149 7 commonly commonly RB cord-011418-hy8xmtiq 149 8 encountered encounter VBN cord-011418-hy8xmtiq 149 9 barriers barrier NNS cord-011418-hy8xmtiq 149 10 can can MD cord-011418-hy8xmtiq 149 11 be be VB cord-011418-hy8xmtiq 149 12 found find VBN cord-011418-hy8xmtiq 149 13 in in IN cord-011418-hy8xmtiq 149 14 Table Table NNP cord-011418-hy8xmtiq 149 15 2 2 CD cord-011418-hy8xmtiq 149 16 . . . cord-011418-hy8xmtiq 150 1 While while IN cord-011418-hy8xmtiq 150 2 the the DT cord-011418-hy8xmtiq 150 3 improvements improvement NNS cord-011418-hy8xmtiq 150 4 in in IN cord-011418-hy8xmtiq 150 5 clinical clinical JJ cord-011418-hy8xmtiq 150 6 outcomes outcome NNS cord-011418-hy8xmtiq 150 7 using use VBG cord-011418-hy8xmtiq 150 8 the the DT cord-011418-hy8xmtiq 150 9 ICU ICU NNP cord-011418-hy8xmtiq 150 10 liberation liberation NN cord-011418-hy8xmtiq 150 11 bundle bundle NN cord-011418-hy8xmtiq 150 12 in in IN cord-011418-hy8xmtiq 150 13 the the DT cord-011418-hy8xmtiq 150 14 critically critically RB cord-011418-hy8xmtiq 150 15 ill ill JJ cord-011418-hy8xmtiq 150 16 adult adult NN cord-011418-hy8xmtiq 150 17 population population NN cord-011418-hy8xmtiq 150 18 is be VBZ cord-011418-hy8xmtiq 150 19 promising promising JJ cord-011418-hy8xmtiq 150 20 , , , cord-011418-hy8xmtiq 150 21 similar similar JJ cord-011418-hy8xmtiq 150 22 outcome outcome NN cord-011418-hy8xmtiq 150 23 data datum NNS cord-011418-hy8xmtiq 150 24 for for IN cord-011418-hy8xmtiq 150 25 bundle bundle NN cord-011418-hy8xmtiq 150 26 implementation implementation NN cord-011418-hy8xmtiq 150 27 in in IN cord-011418-hy8xmtiq 150 28 pediatrics pediatrics NNP cord-011418-hy8xmtiq 150 29 is be VBZ cord-011418-hy8xmtiq 150 30 lacking lack VBG cord-011418-hy8xmtiq 150 31 . . . cord-011418-hy8xmtiq 151 1 Further further JJ cord-011418-hy8xmtiq 151 2 emphasis emphasis NN cord-011418-hy8xmtiq 151 3 should should MD cord-011418-hy8xmtiq 151 4 be be VB cord-011418-hy8xmtiq 151 5 placed place VBN cord-011418-hy8xmtiq 151 6 on on IN cord-011418-hy8xmtiq 151 7 investigating investigate VBG cord-011418-hy8xmtiq 151 8 the the DT cord-011418-hy8xmtiq 151 9 effect effect NN cord-011418-hy8xmtiq 151 10 the the DT cord-011418-hy8xmtiq 151 11 ICU ICU NNP cord-011418-hy8xmtiq 151 12 liberation liberation NN cord-011418-hy8xmtiq 151 13 bundle bundle NN cord-011418-hy8xmtiq 151 14 , , , cord-011418-hy8xmtiq 151 15 as as RB cord-011418-hy8xmtiq 151 16 well well RB cord-011418-hy8xmtiq 151 17 as as IN cord-011418-hy8xmtiq 151 18 each each DT cord-011418-hy8xmtiq 151 19 individual individual JJ cord-011418-hy8xmtiq 151 20 bundle bundle NN cord-011418-hy8xmtiq 151 21 element element NN cord-011418-hy8xmtiq 151 22 , , , cord-011418-hy8xmtiq 151 23 has have VBZ cord-011418-hy8xmtiq 151 24 on on IN cord-011418-hy8xmtiq 151 25 survival survival NN cord-011418-hy8xmtiq 151 26 and and CC cord-011418-hy8xmtiq 151 27 morbidity morbidity NN cord-011418-hy8xmtiq 151 28 related relate VBN cord-011418-hy8xmtiq 151 29 to to IN cord-011418-hy8xmtiq 151 30 critical critical JJ cord-011418-hy8xmtiq 151 31 illness illness NN cord-011418-hy8xmtiq 151 32 in in IN cord-011418-hy8xmtiq 151 33 pediatrics pediatric NNS cord-011418-hy8xmtiq 151 34 . . . cord-011418-hy8xmtiq 152 1 Similarly similarly RB cord-011418-hy8xmtiq 152 2 , , , cord-011418-hy8xmtiq 152 3 PICS PICS NNPS cord-011418-hy8xmtiq 152 4 may may MD cord-011418-hy8xmtiq 152 5 be be VB cord-011418-hy8xmtiq 152 6 a a DT cord-011418-hy8xmtiq 152 7 significant significant JJ cord-011418-hy8xmtiq 152 8 issue issue NN cord-011418-hy8xmtiq 152 9 for for IN cord-011418-hy8xmtiq 152 10 survivors survivor NNS cord-011418-hy8xmtiq 152 11 of of IN cord-011418-hy8xmtiq 152 12 pediatric pediatric JJ cord-011418-hy8xmtiq 152 13 illness illness NN cord-011418-hy8xmtiq 152 14 and and CC cord-011418-hy8xmtiq 152 15 their -PRON- PRP$ cord-011418-hy8xmtiq 152 16 families family NNS cord-011418-hy8xmtiq 152 17 , , , cord-011418-hy8xmtiq 152 18 but but CC cord-011418-hy8xmtiq 152 19 no no DT cord-011418-hy8xmtiq 152 20 unified unified JJ cord-011418-hy8xmtiq 152 21 scales scale NNS cord-011418-hy8xmtiq 152 22 exist exist VBP cord-011418-hy8xmtiq 152 23 in in IN cord-011418-hy8xmtiq 152 24 the the DT cord-011418-hy8xmtiq 152 25 literature literature NN cord-011418-hy8xmtiq 152 26 to to TO cord-011418-hy8xmtiq 152 27 be be VB cord-011418-hy8xmtiq 152 28 able able JJ cord-011418-hy8xmtiq 152 29 to to TO cord-011418-hy8xmtiq 152 30 truly truly RB cord-011418-hy8xmtiq 152 31 quantify quantify VB cord-011418-hy8xmtiq 152 32 the the DT cord-011418-hy8xmtiq 152 33 incidence incidence NN cord-011418-hy8xmtiq 152 34 of of IN cord-011418-hy8xmtiq 152 35 this this DT cord-011418-hy8xmtiq 152 36 problem problem NN cord-011418-hy8xmtiq 152 37 . . . cord-011418-hy8xmtiq 153 1 Unified unified JJ cord-011418-hy8xmtiq 153 2 outcomes outcome NNS cord-011418-hy8xmtiq 153 3 scales scale NNS cord-011418-hy8xmtiq 153 4 are be VBP cord-011418-hy8xmtiq 153 5 needed need VBN cord-011418-hy8xmtiq 153 6 in in IN cord-011418-hy8xmtiq 153 7 order order NN cord-011418-hy8xmtiq 153 8 to to TO cord-011418-hy8xmtiq 153 9 better better RB cord-011418-hy8xmtiq 153 10 understand understand VB cord-011418-hy8xmtiq 153 11 both both CC cord-011418-hy8xmtiq 153 12 the the DT cord-011418-hy8xmtiq 153 13 factors factor NNS cord-011418-hy8xmtiq 153 14 that that WDT cord-011418-hy8xmtiq 153 15 predispose predispose VBP cord-011418-hy8xmtiq 153 16 patients patient NNS cord-011418-hy8xmtiq 153 17 to to IN cord-011418-hy8xmtiq 153 18 developing develop VBG cord-011418-hy8xmtiq 153 19 PICS pic NNS cord-011418-hy8xmtiq 153 20 as as RB cord-011418-hy8xmtiq 153 21 well well RB cord-011418-hy8xmtiq 153 22 as as IN cord-011418-hy8xmtiq 153 23 improve improve VB cord-011418-hy8xmtiq 153 24 long long JJ cord-011418-hy8xmtiq 153 25 - - HYPH cord-011418-hy8xmtiq 153 26 term term NN cord-011418-hy8xmtiq 153 27 outcomes outcome NNS cord-011418-hy8xmtiq 153 28 from from IN cord-011418-hy8xmtiq 153 29 those those DT cord-011418-hy8xmtiq 153 30 affected affect VBN cord-011418-hy8xmtiq 153 31 by by IN cord-011418-hy8xmtiq 153 32 PICS pic NNS cord-011418-hy8xmtiq 153 33 after after IN cord-011418-hy8xmtiq 153 34 hospital hospital NN cord-011418-hy8xmtiq 153 35 discharge discharge NN cord-011418-hy8xmtiq 153 36 . . . cord-011418-hy8xmtiq 154 1 As as IN cord-011418-hy8xmtiq 154 2 the the DT cord-011418-hy8xmtiq 154 3 survivorship survivorship NN cord-011418-hy8xmtiq 154 4 of of IN cord-011418-hy8xmtiq 154 5 patients patient NNS cord-011418-hy8xmtiq 154 6 in in IN cord-011418-hy8xmtiq 154 7 the the DT cord-011418-hy8xmtiq 154 8 PICU PICU NNP cord-011418-hy8xmtiq 154 9 increases increase VBZ cord-011418-hy8xmtiq 154 10 , , , cord-011418-hy8xmtiq 154 11 more more JJR cord-011418-hy8xmtiq 154 12 focus focus NN cord-011418-hy8xmtiq 154 13 will will MD cord-011418-hy8xmtiq 154 14 need need VB cord-011418-hy8xmtiq 154 15 to to TO cord-011418-hy8xmtiq 154 16 be be VB cord-011418-hy8xmtiq 154 17 placed place VBN cord-011418-hy8xmtiq 154 18 on on IN cord-011418-hy8xmtiq 154 19 improving improve VBG cord-011418-hy8xmtiq 154 20 post post JJ cord-011418-hy8xmtiq 154 21 - - JJ cord-011418-hy8xmtiq 154 22 ICU icu JJ cord-011418-hy8xmtiq 154 23 functional functional JJ cord-011418-hy8xmtiq 154 24 status status NN cord-011418-hy8xmtiq 154 25 with with IN cord-011418-hy8xmtiq 154 26 intentional intentional JJ cord-011418-hy8xmtiq 154 27 after after IN cord-011418-hy8xmtiq 154 28 - - HYPH cord-011418-hy8xmtiq 154 29 ICU icu NN cord-011418-hy8xmtiq 154 30 support support NN cord-011418-hy8xmtiq 154 31 and and CC cord-011418-hy8xmtiq 154 32 interventions intervention NNS cord-011418-hy8xmtiq 154 33 . . . cord-011418-hy8xmtiq 155 1 One one CD cord-011418-hy8xmtiq 155 2 novel novel NN cord-011418-hy8xmtiq 155 3 and and CC cord-011418-hy8xmtiq 155 4 developing develop VBG cord-011418-hy8xmtiq 155 5 approach approach NN cord-011418-hy8xmtiq 155 6 to to IN cord-011418-hy8xmtiq 155 7 improving improve VBG cord-011418-hy8xmtiq 155 8 the the DT cord-011418-hy8xmtiq 155 9 lives life NNS cord-011418-hy8xmtiq 155 10 of of IN cord-011418-hy8xmtiq 155 11 survivors survivor NNS cord-011418-hy8xmtiq 155 12 of of IN cord-011418-hy8xmtiq 155 13 critical critical JJ cord-011418-hy8xmtiq 155 14 illness illness NN cord-011418-hy8xmtiq 155 15 is be VBZ cord-011418-hy8xmtiq 155 16 the the DT cord-011418-hy8xmtiq 155 17 development development NN cord-011418-hy8xmtiq 155 18 of of IN cord-011418-hy8xmtiq 155 19 ICU ICU NNP cord-011418-hy8xmtiq 155 20 follow follow NN cord-011418-hy8xmtiq 155 21 - - HYPH cord-011418-hy8xmtiq 155 22 up up RP cord-011418-hy8xmtiq 155 23 clinics clinic NNS cord-011418-hy8xmtiq 155 24 . . . cord-011418-hy8xmtiq 156 1 This this DT cord-011418-hy8xmtiq 156 2 outpatient outpatient NN cord-011418-hy8xmtiq 156 3 support support NN cord-011418-hy8xmtiq 156 4 has have VBZ cord-011418-hy8xmtiq 156 5 been be VBN cord-011418-hy8xmtiq 156 6 used use VBN cord-011418-hy8xmtiq 156 7 as as IN cord-011418-hy8xmtiq 156 8 part part NN cord-011418-hy8xmtiq 156 9 of of IN cord-011418-hy8xmtiq 156 10 post post JJ cord-011418-hy8xmtiq 156 11 - - JJ cord-011418-hy8xmtiq 156 12 ICU icu JJ cord-011418-hy8xmtiq 156 13 recovery recovery NN cord-011418-hy8xmtiq 156 14 models model NNS cord-011418-hy8xmtiq 156 15 for for IN cord-011418-hy8xmtiq 156 16 some some DT cord-011418-hy8xmtiq 156 17 adult adult NN cord-011418-hy8xmtiq 156 18 units unit NNS cord-011418-hy8xmtiq 156 19 after after IN cord-011418-hy8xmtiq 156 20 ICU ICU NNP cord-011418-hy8xmtiq 156 21 discharge discharge NN cord-011418-hy8xmtiq 156 22 , , , cord-011418-hy8xmtiq 156 23 though though IN cord-011418-hy8xmtiq 156 24 its -PRON- PRP$ cord-011418-hy8xmtiq 156 25 impact impact NN cord-011418-hy8xmtiq 156 26 on on IN cord-011418-hy8xmtiq 156 27 recovery recovery NN cord-011418-hy8xmtiq 156 28 remains remain VBZ cord-011418-hy8xmtiq 156 29 largely largely RB cord-011418-hy8xmtiq 156 30 unknown unknown JJ cord-011418-hy8xmtiq 156 31 . . . cord-011418-hy8xmtiq 157 1 This this DT cord-011418-hy8xmtiq 157 2 intervention intervention NN cord-011418-hy8xmtiq 157 3 has have VBZ cord-011418-hy8xmtiq 157 4 not not RB cord-011418-hy8xmtiq 157 5 been be VBN cord-011418-hy8xmtiq 157 6 adopted adopt VBN cord-011418-hy8xmtiq 157 7 widely widely RB cord-011418-hy8xmtiq 157 8 , , , cord-011418-hy8xmtiq 157 9 nor nor CC cord-011418-hy8xmtiq 157 10 has have VBZ cord-011418-hy8xmtiq 157 11 it -PRON- PRP cord-011418-hy8xmtiq 157 12 been be VBN cord-011418-hy8xmtiq 157 13 studied study VBN cord-011418-hy8xmtiq 157 14 extensively extensively RB cord-011418-hy8xmtiq 157 15 in in IN cord-011418-hy8xmtiq 157 16 the the DT cord-011418-hy8xmtiq 157 17 pediatric pediatric JJ cord-011418-hy8xmtiq 157 18 population population NN cord-011418-hy8xmtiq 157 19 . . . cord-011418-hy8xmtiq 158 1 With with IN cord-011418-hy8xmtiq 158 2 advances advance NNS cord-011418-hy8xmtiq 158 3 in in IN cord-011418-hy8xmtiq 158 4 technology technology NN cord-011418-hy8xmtiq 158 5 and and CC cord-011418-hy8xmtiq 158 6 the the DT cord-011418-hy8xmtiq 158 7 availability availability NN cord-011418-hy8xmtiq 158 8 of of IN cord-011418-hy8xmtiq 158 9 telemedicine telemedicine NN cord-011418-hy8xmtiq 158 10 services service NNS cord-011418-hy8xmtiq 158 11 , , , cord-011418-hy8xmtiq 158 12 future future JJ cord-011418-hy8xmtiq 158 13 research research NN cord-011418-hy8xmtiq 158 14 should should MD cord-011418-hy8xmtiq 158 15 explore explore VB cord-011418-hy8xmtiq 158 16 whether whether IN cord-011418-hy8xmtiq 158 17 a a DT cord-011418-hy8xmtiq 158 18 model model NN cord-011418-hy8xmtiq 158 19 for for IN cord-011418-hy8xmtiq 158 20 ICU ICU NNP cord-011418-hy8xmtiq 158 21 follow follow NN cord-011418-hy8xmtiq 158 22 - - HYPH cord-011418-hy8xmtiq 158 23 up up NN cord-011418-hy8xmtiq 158 24 can can MD cord-011418-hy8xmtiq 158 25 further further RB cord-011418-hy8xmtiq 158 26 improve improve VB cord-011418-hy8xmtiq 158 27 the the DT cord-011418-hy8xmtiq 158 28 after after IN cord-011418-hy8xmtiq 158 29 - - HYPH cord-011418-hy8xmtiq 158 30 ICU icu NN cord-011418-hy8xmtiq 158 31 recovery recovery NN cord-011418-hy8xmtiq 158 32 for for IN cord-011418-hy8xmtiq 158 33 critically critically RB cord-011418-hy8xmtiq 158 34 ill ill JJ cord-011418-hy8xmtiq 158 35 pediatric pediatric JJ cord-011418-hy8xmtiq 158 36 patients patient NNS cord-011418-hy8xmtiq 158 37 and and CC cord-011418-hy8xmtiq 158 38 their -PRON- PRP$ cord-011418-hy8xmtiq 158 39 families family NNS cord-011418-hy8xmtiq 158 40 . . . cord-011418-hy8xmtiq 159 1 Medical medical JJ cord-011418-hy8xmtiq 159 2 advancements advancement NNS cord-011418-hy8xmtiq 159 3 have have VBP cord-011418-hy8xmtiq 159 4 led lead VBN cord-011418-hy8xmtiq 159 5 to to IN cord-011418-hy8xmtiq 159 6 a a DT cord-011418-hy8xmtiq 159 7 steady steady JJ cord-011418-hy8xmtiq 159 8 increase increase NN cord-011418-hy8xmtiq 159 9 in in IN cord-011418-hy8xmtiq 159 10 survival survival NN cord-011418-hy8xmtiq 159 11 among among IN cord-011418-hy8xmtiq 159 12 pediatric pediatric JJ cord-011418-hy8xmtiq 159 13 patients patient NNS cord-011418-hy8xmtiq 159 14 suffering suffer VBG cord-011418-hy8xmtiq 159 15 from from IN cord-011418-hy8xmtiq 159 16 critical critical JJ cord-011418-hy8xmtiq 159 17 illness illness NN cord-011418-hy8xmtiq 159 18 , , , cord-011418-hy8xmtiq 159 19 though though IN cord-011418-hy8xmtiq 159 20 morbidity morbidity NN cord-011418-hy8xmtiq 159 21 related relate VBN cord-011418-hy8xmtiq 159 22 to to IN cord-011418-hy8xmtiq 159 23 long long JJ cord-011418-hy8xmtiq 159 24 - - HYPH cord-011418-hy8xmtiq 159 25 term term NN cord-011418-hy8xmtiq 159 26 physical physical JJ cord-011418-hy8xmtiq 159 27 , , , cord-011418-hy8xmtiq 159 28 cognitive cognitive JJ cord-011418-hy8xmtiq 159 29 , , , cord-011418-hy8xmtiq 159 30 and and CC cord-011418-hy8xmtiq 159 31 psychological psychological JJ cord-011418-hy8xmtiq 159 32 effects effect NNS cord-011418-hy8xmtiq 159 33 persists persist VBZ cord-011418-hy8xmtiq 159 34 for for IN cord-011418-hy8xmtiq 159 35 many many JJ cord-011418-hy8xmtiq 159 36 pediatric pediatric JJ cord-011418-hy8xmtiq 159 37 patients patient NNS cord-011418-hy8xmtiq 159 38 and and CC cord-011418-hy8xmtiq 159 39 their -PRON- PRP$ cord-011418-hy8xmtiq 159 40 families family NNS cord-011418-hy8xmtiq 159 41 after after IN cord-011418-hy8xmtiq 159 42 hospital hospital NN cord-011418-hy8xmtiq 159 43 discharge discharge NN cord-011418-hy8xmtiq 159 44 . . . cord-011418-hy8xmtiq 160 1 Use use NN cord-011418-hy8xmtiq 160 2 of of IN cord-011418-hy8xmtiq 160 3 systematic systematic JJ cord-011418-hy8xmtiq 160 4 care care NN cord-011418-hy8xmtiq 160 5 bundles bundle NNS cord-011418-hy8xmtiq 160 6 such such JJ cord-011418-hy8xmtiq 160 7 as as IN cord-011418-hy8xmtiq 160 8 the the DT cord-011418-hy8xmtiq 160 9 ICU ICU NNP cord-011418-hy8xmtiq 160 10 liberation liberation NN cord-011418-hy8xmtiq 160 11 bundle bundle NN cord-011418-hy8xmtiq 160 12 may may MD cord-011418-hy8xmtiq 160 13 further further RB cord-011418-hy8xmtiq 160 14 improve improve VB cord-011418-hy8xmtiq 160 15 survival survival NN cord-011418-hy8xmtiq 160 16 in in IN cord-011418-hy8xmtiq 160 17 pediatric pediatric JJ cord-011418-hy8xmtiq 160 18 patients patient NNS cord-011418-hy8xmtiq 160 19 as as RB cord-011418-hy8xmtiq 160 20 well well RB cord-011418-hy8xmtiq 160 21 as as IN cord-011418-hy8xmtiq 160 22 decrease decrease VB cord-011418-hy8xmtiq 160 23 the the DT cord-011418-hy8xmtiq 160 24 incidence incidence NN cord-011418-hy8xmtiq 160 25 of of IN cord-011418-hy8xmtiq 160 26 PICS PICS NNPS cord-011418-hy8xmtiq 160 27 . . . cord-011418-hy8xmtiq 161 1 Widespread widespread JJ cord-011418-hy8xmtiq 161 2 ICU ICU NNP cord-011418-hy8xmtiq 161 3 liberation liberation NN cord-011418-hy8xmtiq 161 4 bundle bundle NN cord-011418-hy8xmtiq 161 5 implementation implementation NN cord-011418-hy8xmtiq 161 6 in in IN cord-011418-hy8xmtiq 161 7 pediatrics pediatric NNS cord-011418-hy8xmtiq 161 8 with with IN cord-011418-hy8xmtiq 161 9 systematic systematic JJ cord-011418-hy8xmtiq 161 10 outcome outcome NN cord-011418-hy8xmtiq 161 11 monitoring monitor VBG cord-011418-hy8xmtiq 161 12 Low low JJ cord-011418-hy8xmtiq 161 13 prioritization prioritization NN cord-011418-hy8xmtiq 161 14 and and CC cord-011418-hy8xmtiq 161 15 competing compete VBG cord-011418-hy8xmtiq 161 16 priorities priority NNS cord-011418-hy8xmtiq 161 17 and and CC cord-011418-hy8xmtiq 161 18 analysis analysis NN cord-011418-hy8xmtiq 161 19 will will MD cord-011418-hy8xmtiq 161 20 be be VB cord-011418-hy8xmtiq 161 21 essential essential JJ cord-011418-hy8xmtiq 161 22 for for IN cord-011418-hy8xmtiq 161 23 further further JJ cord-011418-hy8xmtiq 161 24 advances advance NNS cord-011418-hy8xmtiq 161 25 in in IN cord-011418-hy8xmtiq 161 26 outcomes outcome NNS cord-011418-hy8xmtiq 161 27 for for IN cord-011418-hy8xmtiq 161 28 pediatric pediatric JJ cord-011418-hy8xmtiq 161 29 survivors survivor NNS cord-011418-hy8xmtiq 161 30 of of IN cord-011418-hy8xmtiq 161 31 critical critical JJ cord-011418-hy8xmtiq 161 32 illness illness NN cord-011418-hy8xmtiq 161 33 . . . cord-011418-hy8xmtiq 162 1 Conflict conflict NN cord-011418-hy8xmtiq 162 2 of of IN cord-011418-hy8xmtiq 162 3 Interest interest NN cord-011418-hy8xmtiq 163 1 The the DT cord-011418-hy8xmtiq 163 2 authors author NNS cord-011418-hy8xmtiq 163 3 declare declare VBP cord-011418-hy8xmtiq 163 4 that that IN cord-011418-hy8xmtiq 163 5 they -PRON- PRP cord-011418-hy8xmtiq 163 6 have have VBP cord-011418-hy8xmtiq 163 7 no no DT cord-011418-hy8xmtiq 163 8 conflict conflict NN cord-011418-hy8xmtiq 163 9 of of IN cord-011418-hy8xmtiq 163 10 interest interest NN cord-011418-hy8xmtiq 163 11 . . . cord-011418-hy8xmtiq 164 1 Human human JJ cord-011418-hy8xmtiq 164 2 and and CC cord-011418-hy8xmtiq 164 3 Animal Animal NNP cord-011418-hy8xmtiq 164 4 Rights Rights NNPS cord-011418-hy8xmtiq 165 1 This this DT cord-011418-hy8xmtiq 165 2 article article NN cord-011418-hy8xmtiq 165 3 does do VBZ cord-011418-hy8xmtiq 165 4 not not RB cord-011418-hy8xmtiq 165 5 contain contain VB cord-011418-hy8xmtiq 165 6 any any DT cord-011418-hy8xmtiq 165 7 studies study NNS cord-011418-hy8xmtiq 165 8 with with IN cord-011418-hy8xmtiq 165 9 human human JJ cord-011418-hy8xmtiq 165 10 or or CC cord-011418-hy8xmtiq 165 11 animal animal NN cord-011418-hy8xmtiq 165 12 subjects subject NNS cord-011418-hy8xmtiq 165 13 performed perform VBN cord-011418-hy8xmtiq 165 14 by by IN cord-011418-hy8xmtiq 165 15 any any DT cord-011418-hy8xmtiq 165 16 of of IN cord-011418-hy8xmtiq 165 17 the the DT cord-011418-hy8xmtiq 165 18 authors author NNS cord-011418-hy8xmtiq 165 19 . . . cord-011418-hy8xmtiq 166 1 A a DT cord-011418-hy8xmtiq 166 2 history history NN cord-011418-hy8xmtiq 166 3 of of IN cord-011418-hy8xmtiq 166 4 pediatric pediatric JJ cord-011418-hy8xmtiq 166 5 critical critical JJ cord-011418-hy8xmtiq 166 6 care care NN cord-011418-hy8xmtiq 166 7 medicine medicine NN cord-011418-hy8xmtiq 166 8 Three three CD cord-011418-hy8xmtiq 166 9 decades decade NNS cord-011418-hy8xmtiq 166 10 of of IN cord-011418-hy8xmtiq 166 11 pediatric pediatric JJ cord-011418-hy8xmtiq 166 12 intensive intensive JJ cord-011418-hy8xmtiq 166 13 care care NN cord-011418-hy8xmtiq 166 14 : : : cord-011418-hy8xmtiq 166 15 who who WP cord-011418-hy8xmtiq 166 16 was be VBD cord-011418-hy8xmtiq 166 17 admitted admit VBN cord-011418-hy8xmtiq 166 18 , , , cord-011418-hy8xmtiq 166 19 what what WP cord-011418-hy8xmtiq 166 20 happened happen VBD cord-011418-hy8xmtiq 166 21 in in IN cord-011418-hy8xmtiq 166 22 intensive intensive JJ cord-011418-hy8xmtiq 166 23 care care NN cord-011418-hy8xmtiq 166 24 , , , cord-011418-hy8xmtiq 166 25 and and CC cord-011418-hy8xmtiq 166 26 what what WP cord-011418-hy8xmtiq 166 27 happened happen VBD cord-011418-hy8xmtiq 166 28 afterward afterward RB cord-011418-hy8xmtiq 166 29 . . . cord-011418-hy8xmtiq 167 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 167 2 Crit Crit NNP cord-011418-hy8xmtiq 167 3 Care Care NNP cord-011418-hy8xmtiq 167 4 Med Med NNP cord-011418-hy8xmtiq 167 5 Functional functional JJ cord-011418-hy8xmtiq 167 6 outcomes outcome NNS cord-011418-hy8xmtiq 167 7 and and CC cord-011418-hy8xmtiq 167 8 physical physical JJ cord-011418-hy8xmtiq 167 9 impairments impairment NNS cord-011418-hy8xmtiq 167 10 in in IN cord-011418-hy8xmtiq 167 11 pediatric pediatric JJ cord-011418-hy8xmtiq 167 12 critical critical JJ cord-011418-hy8xmtiq 167 13 care care NN cord-011418-hy8xmtiq 167 14 survivors survivor NNS cord-011418-hy8xmtiq 167 15 : : : cord-011418-hy8xmtiq 167 16 a a DT cord-011418-hy8xmtiq 167 17 scoping scoping NN cord-011418-hy8xmtiq 167 18 review review NN cord-011418-hy8xmtiq 167 19 . . . cord-011418-hy8xmtiq 168 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 168 2 Crit Crit NNP cord-011418-hy8xmtiq 168 3 Care Care NNP cord-011418-hy8xmtiq 168 4 Med Med NNP cord-011418-hy8xmtiq 168 5 Outcome outcome NN cord-011418-hy8xmtiq 168 6 at at IN cord-011418-hy8xmtiq 168 7 6 6 CD cord-011418-hy8xmtiq 168 8 months month NNS cord-011418-hy8xmtiq 168 9 after after IN cord-011418-hy8xmtiq 168 10 admission admission NN cord-011418-hy8xmtiq 168 11 for for IN cord-011418-hy8xmtiq 168 12 pediatric pediatric JJ cord-011418-hy8xmtiq 168 13 intensive intensive JJ cord-011418-hy8xmtiq 168 14 care care NN cord-011418-hy8xmtiq 168 15 : : : cord-011418-hy8xmtiq 168 16 a a DT cord-011418-hy8xmtiq 168 17 report report NN cord-011418-hy8xmtiq 168 18 of of IN cord-011418-hy8xmtiq 168 19 a a DT cord-011418-hy8xmtiq 168 20 national national JJ cord-011418-hy8xmtiq 168 21 study study NN cord-011418-hy8xmtiq 168 22 of of IN cord-011418-hy8xmtiq 168 23 pediatric pediatric JJ cord-011418-hy8xmtiq 168 24 intensive intensive JJ cord-011418-hy8xmtiq 168 25 care care NN cord-011418-hy8xmtiq 168 26 units unit NNS cord-011418-hy8xmtiq 168 27 in in IN cord-011418-hy8xmtiq 168 28 the the DT cord-011418-hy8xmtiq 168 29 United United NNP cord-011418-hy8xmtiq 168 30 Kingdom Kingdom NNP cord-011418-hy8xmtiq 168 31 Long Long NNP cord-011418-hy8xmtiq 168 32 - - HYPH cord-011418-hy8xmtiq 168 33 term term NN cord-011418-hy8xmtiq 168 34 function function NN cord-011418-hy8xmtiq 168 35 after after IN cord-011418-hy8xmtiq 168 36 pediatric pediatric JJ cord-011418-hy8xmtiq 168 37 critical critical JJ cord-011418-hy8xmtiq 168 38 illness illness NN cord-011418-hy8xmtiq 168 39 : : : cord-011418-hy8xmtiq 168 40 results result NNS cord-011418-hy8xmtiq 168 41 from from IN cord-011418-hy8xmtiq 168 42 the the DT cord-011418-hy8xmtiq 168 43 survivor survivor NN cord-011418-hy8xmtiq 168 44 outcomes outcome NNS cord-011418-hy8xmtiq 168 45 study study VBP cord-011418-hy8xmtiq 169 1 * * NFP cord-011418-hy8xmtiq 169 2 . . . cord-011418-hy8xmtiq 170 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 170 2 Crit Crit NNP cord-011418-hy8xmtiq 170 3 Care Care NNP cord-011418-hy8xmtiq 170 4 Med Med NNP cord-011418-hy8xmtiq 170 5 Pediatric Pediatric NNP cord-011418-hy8xmtiq 170 6 intensive intensive JJ cord-011418-hy8xmtiq 170 7 care care NN cord-011418-hy8xmtiq 170 8 outcomes outcome NNS cord-011418-hy8xmtiq 170 9 : : : cord-011418-hy8xmtiq 170 10 development development NN cord-011418-hy8xmtiq 170 11 of of IN cord-011418-hy8xmtiq 170 12 new new JJ cord-011418-hy8xmtiq 170 13 morbidities morbidity NNS cord-011418-hy8xmtiq 170 14 during during IN cord-011418-hy8xmtiq 170 15 pediatric pediatric JJ cord-011418-hy8xmtiq 170 16 critical critical JJ cord-011418-hy8xmtiq 170 17 care care NN cord-011418-hy8xmtiq 170 18 . . . cord-011418-hy8xmtiq 171 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 171 2 Crit Crit NNP cord-011418-hy8xmtiq 171 3 Care Care NNP cord-011418-hy8xmtiq 171 4 Med Med NNP cord-011418-hy8xmtiq 171 5 Relationship relationship NN cord-011418-hy8xmtiq 171 6 of of IN cord-011418-hy8xmtiq 171 7 illness illness NN cord-011418-hy8xmtiq 171 8 severity severity NN cord-011418-hy8xmtiq 171 9 and and CC cord-011418-hy8xmtiq 171 10 length length NN cord-011418-hy8xmtiq 171 11 of of IN cord-011418-hy8xmtiq 171 12 stay stay NN cord-011418-hy8xmtiq 171 13 to to IN cord-011418-hy8xmtiq 171 14 functional functional JJ cord-011418-hy8xmtiq 171 15 outcomes outcome NNS cord-011418-hy8xmtiq 171 16 in in IN cord-011418-hy8xmtiq 171 17 the the DT cord-011418-hy8xmtiq 171 18 pediatric pediatric JJ cord-011418-hy8xmtiq 171 19 intensive intensive JJ cord-011418-hy8xmtiq 171 20 care care NN cord-011418-hy8xmtiq 171 21 unit unit NN cord-011418-hy8xmtiq 171 22 : : : cord-011418-hy8xmtiq 171 23 a a DT cord-011418-hy8xmtiq 171 24 multi multi JJ cord-011418-hy8xmtiq 171 25 - - JJ cord-011418-hy8xmtiq 171 26 institutional institutional JJ cord-011418-hy8xmtiq 171 27 study study NN cord-011418-hy8xmtiq 171 28 Risk risk NN cord-011418-hy8xmtiq 171 29 factors factor NNS cord-011418-hy8xmtiq 171 30 for for IN cord-011418-hy8xmtiq 171 31 acquiring acquire VBG cord-011418-hy8xmtiq 171 32 functional functional JJ cord-011418-hy8xmtiq 171 33 and and CC cord-011418-hy8xmtiq 171 34 cognitive cognitive JJ cord-011418-hy8xmtiq 171 35 disabilities disability NNS cord-011418-hy8xmtiq 171 36 during during IN cord-011418-hy8xmtiq 171 37 admission admission NN cord-011418-hy8xmtiq 171 38 to to IN cord-011418-hy8xmtiq 171 39 a a DT cord-011418-hy8xmtiq 171 40 PICU PICU NNP cord-011418-hy8xmtiq 171 41 . . . cord-011418-hy8xmtiq 172 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 172 2 Crit Crit NNP cord-011418-hy8xmtiq 172 3 Care Care NNP cord-011418-hy8xmtiq 172 4 Med Med NNP cord-011418-hy8xmtiq 173 1 The the DT cord-011418-hy8xmtiq 173 2 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 173 3 bundle bundle NN cord-011418-hy8xmtiq 173 4 in in IN cord-011418-hy8xmtiq 173 5 critical critical JJ cord-011418-hy8xmtiq 173 6 care care NN cord-011418-hy8xmtiq 174 1 The the DT cord-011418-hy8xmtiq 174 2 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 174 3 bundle bundle NN cord-011418-hy8xmtiq 174 4 : : : cord-011418-hy8xmtiq 174 5 science science NN cord-011418-hy8xmtiq 174 6 and and CC cord-011418-hy8xmtiq 174 7 philosophy philosophy NN cord-011418-hy8xmtiq 174 8 of of IN cord-011418-hy8xmtiq 174 9 how how WRB cord-011418-hy8xmtiq 174 10 ICU ICU NNP cord-011418-hy8xmtiq 174 11 liberation liberation NN cord-011418-hy8xmtiq 174 12 serves serve VBZ cord-011418-hy8xmtiq 174 13 patients patient NNS cord-011418-hy8xmtiq 174 14 and and CC cord-011418-hy8xmtiq 174 15 families family NNS cord-011418-hy8xmtiq 174 16 Conceptualizing conceptualize VBG cord-011418-hy8xmtiq 174 17 post post VBP cord-011418-hy8xmtiq 174 18 intensive intensive JJ cord-011418-hy8xmtiq 174 19 care care NN cord-011418-hy8xmtiq 174 20 syndrome syndrome NN cord-011418-hy8xmtiq 174 21 in in IN cord-011418-hy8xmtiq 174 22 children child NNS cord-011418-hy8xmtiq 175 1 -the -the NFP cord-011418-hy8xmtiq 176 1 PICS pic NNS cord-011418-hy8xmtiq 176 2 - - HYPH cord-011418-hy8xmtiq 176 3 p p NN cord-011418-hy8xmtiq 176 4 framework framework NN cord-011418-hy8xmtiq 176 5 Characteristics characteristic NNS cord-011418-hy8xmtiq 176 6 of of IN cord-011418-hy8xmtiq 176 7 postintensive postintensive NNP cord-011418-hy8xmtiq 176 8 care care NN cord-011418-hy8xmtiq 176 9 syndrome syndrome NN cord-011418-hy8xmtiq 176 10 in in IN cord-011418-hy8xmtiq 176 11 survivors survivor NNS cord-011418-hy8xmtiq 176 12 of of IN cord-011418-hy8xmtiq 176 13 pediatric pediatric JJ cord-011418-hy8xmtiq 176 14 critical critical JJ cord-011418-hy8xmtiq 176 15 illness illness NN cord-011418-hy8xmtiq 176 16 : : : cord-011418-hy8xmtiq 176 17 a a DT cord-011418-hy8xmtiq 176 18 systematic systematic JJ cord-011418-hy8xmtiq 176 19 review review NN cord-011418-hy8xmtiq 176 20 Children Children NNP cord-011418-hy8xmtiq 176 21 's 's POS cord-011418-hy8xmtiq 176 22 psychological psychological JJ cord-011418-hy8xmtiq 176 23 and and CC cord-011418-hy8xmtiq 176 24 behavioral behavioral JJ cord-011418-hy8xmtiq 176 25 responses response NNS cord-011418-hy8xmtiq 176 26 following follow VBG cord-011418-hy8xmtiq 176 27 pediatric pediatric JJ cord-011418-hy8xmtiq 176 28 intensive intensive JJ cord-011418-hy8xmtiq 176 29 care care NN cord-011418-hy8xmtiq 176 30 unit unit NN cord-011418-hy8xmtiq 176 31 hospitalization hospitalization NN cord-011418-hy8xmtiq 176 32 : : : cord-011418-hy8xmtiq 176 33 the the DT cord-011418-hy8xmtiq 176 34 caring care VBG cord-011418-hy8xmtiq 176 35 intensively intensively RB cord-011418-hy8xmtiq 176 36 study study NN cord-011418-hy8xmtiq 176 37 Patterns pattern NNS cord-011418-hy8xmtiq 176 38 of of IN cord-011418-hy8xmtiq 176 39 post post JJ cord-011418-hy8xmtiq 176 40 - - JJ cord-011418-hy8xmtiq 176 41 traumatic traumatic JJ cord-011418-hy8xmtiq 176 42 stress stress NN cord-011418-hy8xmtiq 176 43 symptoms symptom NNS cord-011418-hy8xmtiq 176 44 in in IN cord-011418-hy8xmtiq 176 45 families family NNS cord-011418-hy8xmtiq 176 46 after after IN cord-011418-hy8xmtiq 176 47 paediatric paediatric JJ cord-011418-hy8xmtiq 176 48 intensive intensive JJ cord-011418-hy8xmtiq 176 49 care care NN cord-011418-hy8xmtiq 176 50 Posttraumatic posttraumatic JJ cord-011418-hy8xmtiq 176 51 stress stress NN cord-011418-hy8xmtiq 176 52 disorder disorder NN cord-011418-hy8xmtiq 176 53 in in IN cord-011418-hy8xmtiq 176 54 children child NNS cord-011418-hy8xmtiq 176 55 and and CC cord-011418-hy8xmtiq 176 56 their -PRON- PRP$ cord-011418-hy8xmtiq 176 57 parents parent NNS cord-011418-hy8xmtiq 176 58 following follow VBG cord-011418-hy8xmtiq 176 59 admission admission NN cord-011418-hy8xmtiq 176 60 to to IN cord-011418-hy8xmtiq 176 61 the the DT cord-011418-hy8xmtiq 176 62 pediatric pediatric JJ cord-011418-hy8xmtiq 176 63 intensive intensive JJ cord-011418-hy8xmtiq 176 64 care care NN cord-011418-hy8xmtiq 176 65 unit unit NN cord-011418-hy8xmtiq 176 66 : : : cord-011418-hy8xmtiq 176 67 a a DT cord-011418-hy8xmtiq 176 68 review review NN cord-011418-hy8xmtiq 176 69 . . . cord-011418-hy8xmtiq 177 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 177 2 Crit Crit NNP cord-011418-hy8xmtiq 177 3 Care Care NNP cord-011418-hy8xmtiq 177 4 Med Med NNP cord-011418-hy8xmtiq 177 5 Functional functional JJ cord-011418-hy8xmtiq 177 6 recovery recovery NN cord-011418-hy8xmtiq 177 7 in in IN cord-011418-hy8xmtiq 177 8 critically critically RB cord-011418-hy8xmtiq 177 9 ill ill JJ cord-011418-hy8xmtiq 177 10 children child NNS cord-011418-hy8xmtiq 177 11 , , , cord-011418-hy8xmtiq 177 12 the the DT cord-011418-hy8xmtiq 177 13 " " `` cord-011418-hy8xmtiq 177 14 weeCover weeCover NNP cord-011418-hy8xmtiq 177 15 " " '' cord-011418-hy8xmtiq 177 16 multicenter multicenter JJ cord-011418-hy8xmtiq 177 17 study study NN cord-011418-hy8xmtiq 177 18 The the DT cord-011418-hy8xmtiq 177 19 association association NN cord-011418-hy8xmtiq 177 20 between between IN cord-011418-hy8xmtiq 177 21 parent parent NN cord-011418-hy8xmtiq 177 22 PTSD PTSD NNP cord-011418-hy8xmtiq 177 23 / / SYM cord-011418-hy8xmtiq 177 24 depression depression NN cord-011418-hy8xmtiq 177 25 symptoms symptom NNS cord-011418-hy8xmtiq 177 26 and and CC cord-011418-hy8xmtiq 177 27 child child NN cord-011418-hy8xmtiq 177 28 PTSD PTSD NNP cord-011418-hy8xmtiq 177 29 symptoms symptom NNS cord-011418-hy8xmtiq 177 30 : : : cord-011418-hy8xmtiq 177 31 a a DT cord-011418-hy8xmtiq 177 32 meta meta JJ cord-011418-hy8xmtiq 177 33 - - HYPH cord-011418-hy8xmtiq 177 34 analysis analysis NN cord-011418-hy8xmtiq 177 35 Caring care VBG cord-011418-hy8xmtiq 177 36 for for IN cord-011418-hy8xmtiq 177 37 critically critically RB cord-011418-hy8xmtiq 177 38 ill ill JJ cord-011418-hy8xmtiq 177 39 patients patient NNS cord-011418-hy8xmtiq 177 40 with with IN cord-011418-hy8xmtiq 177 41 the the DT cord-011418-hy8xmtiq 177 42 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 177 43 bundle bundle NN cord-011418-hy8xmtiq 177 44 Improving improve VBG cord-011418-hy8xmtiq 177 45 hospital hospital NN cord-011418-hy8xmtiq 177 46 survival survival NN cord-011418-hy8xmtiq 177 47 and and CC cord-011418-hy8xmtiq 177 48 reducing reduce VBG cord-011418-hy8xmtiq 177 49 brain brain NN cord-011418-hy8xmtiq 177 50 dysfunction dysfunction NN cord-011418-hy8xmtiq 177 51 at at IN cord-011418-hy8xmtiq 177 52 Seven seven CD cord-011418-hy8xmtiq 177 53 California California NNP cord-011418-hy8xmtiq 177 54 Community Community NNP cord-011418-hy8xmtiq 177 55 Hospitals Hospitals NNPS cord-011418-hy8xmtiq 177 56 : : : cord-011418-hy8xmtiq 177 57 implementing implement VBG cord-011418-hy8xmtiq 177 58 PAD pad NN cord-011418-hy8xmtiq 177 59 guidelines guideline NNS cord-011418-hy8xmtiq 177 60 via via IN cord-011418-hy8xmtiq 177 61 the the DT cord-011418-hy8xmtiq 177 62 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 177 63 bundle bundle NN cord-011418-hy8xmtiq 177 64 in in IN cord-011418-hy8xmtiq 177 65 6064 6064 CD cord-011418-hy8xmtiq 177 66 patients patient NNS cord-011418-hy8xmtiq 177 67 Pain pain NN cord-011418-hy8xmtiq 177 68 assessment assessment NN cord-011418-hy8xmtiq 177 69 practices practice NNS cord-011418-hy8xmtiq 177 70 in in IN cord-011418-hy8xmtiq 177 71 the the DT cord-011418-hy8xmtiq 177 72 pediatric pediatric JJ cord-011418-hy8xmtiq 177 73 intensive intensive JJ cord-011418-hy8xmtiq 177 74 care care NN cord-011418-hy8xmtiq 177 75 unit unit NN cord-011418-hy8xmtiq 177 76 The the DT cord-011418-hy8xmtiq 177 77 FLACC FLACC NNP cord-011418-hy8xmtiq 177 78 : : : cord-011418-hy8xmtiq 177 79 a a DT cord-011418-hy8xmtiq 177 80 behavioral behavioral JJ cord-011418-hy8xmtiq 177 81 scale scale NN cord-011418-hy8xmtiq 177 82 for for IN cord-011418-hy8xmtiq 177 83 scoring score VBG cord-011418-hy8xmtiq 177 84 postoperative postoperative JJ cord-011418-hy8xmtiq 177 85 pain pain NN cord-011418-hy8xmtiq 177 86 in in IN cord-011418-hy8xmtiq 177 87 young young JJ cord-011418-hy8xmtiq 177 88 children child NNS cord-011418-hy8xmtiq 177 89 Pain pain NN cord-011418-hy8xmtiq 177 90 assessment assessment NN cord-011418-hy8xmtiq 177 91 in in IN cord-011418-hy8xmtiq 177 92 nonverbal nonverbal JJ cord-011418-hy8xmtiq 177 93 children child NNS cord-011418-hy8xmtiq 177 94 with with IN cord-011418-hy8xmtiq 177 95 severe severe JJ cord-011418-hy8xmtiq 177 96 cognitive cognitive JJ cord-011418-hy8xmtiq 177 97 impairments impairment NNS cord-011418-hy8xmtiq 177 98 : : : cord-011418-hy8xmtiq 177 99 the the DT cord-011418-hy8xmtiq 177 100 individualized individualized JJ cord-011418-hy8xmtiq 177 101 numeric numeric JJ cord-011418-hy8xmtiq 177 102 rating rating NN cord-011418-hy8xmtiq 177 103 scale scale NN cord-011418-hy8xmtiq 177 104 ( ( -LRB- cord-011418-hy8xmtiq 177 105 INRS INRS NNP cord-011418-hy8xmtiq 177 106 ) ) -RRB- cord-011418-hy8xmtiq 177 107 Pain pain NN cord-011418-hy8xmtiq 177 108 in in IN cord-011418-hy8xmtiq 177 109 children child NNS cord-011418-hy8xmtiq 177 110 : : : cord-011418-hy8xmtiq 177 111 comparison comparison NN cord-011418-hy8xmtiq 177 112 of of IN cord-011418-hy8xmtiq 177 113 assessment assessment NN cord-011418-hy8xmtiq 177 114 scales scale NNS cord-011418-hy8xmtiq 177 115 . . . cord-011418-hy8xmtiq 178 1 Okla Okla NNP cord-011418-hy8xmtiq 178 2 Nurse Nurse NNP cord-011418-hy8xmtiq 178 3 Distraction distraction NN cord-011418-hy8xmtiq 178 4 using use VBG cord-011418-hy8xmtiq 178 5 the the DT cord-011418-hy8xmtiq 178 6 BUZZY BUZZY NNP cord-011418-hy8xmtiq 178 7 for for IN cord-011418-hy8xmtiq 178 8 children child NNS cord-011418-hy8xmtiq 178 9 during during IN cord-011418-hy8xmtiq 178 10 an an DT cord-011418-hy8xmtiq 178 11 IV IV NNP cord-011418-hy8xmtiq 178 12 insertion insertion NN cord-011418-hy8xmtiq 178 13 Relief relief NN cord-011418-hy8xmtiq 178 14 of of IN cord-011418-hy8xmtiq 178 15 pain pain NN cord-011418-hy8xmtiq 178 16 and and CC cord-011418-hy8xmtiq 178 17 anxiety anxiety NN cord-011418-hy8xmtiq 178 18 in in IN cord-011418-hy8xmtiq 178 19 pediatric pediatric JJ cord-011418-hy8xmtiq 178 20 patients patient NNS cord-011418-hy8xmtiq 178 21 in in IN cord-011418-hy8xmtiq 178 22 emergency emergency NN cord-011418-hy8xmtiq 178 23 medical medical JJ cord-011418-hy8xmtiq 178 24 systems system NNS cord-011418-hy8xmtiq 178 25 Pain pain NN cord-011418-hy8xmtiq 178 26 outcomes outcome NNS cord-011418-hy8xmtiq 178 27 in in IN cord-011418-hy8xmtiq 178 28 a a DT cord-011418-hy8xmtiq 178 29 US US NNP cord-011418-hy8xmtiq 178 30 children child NNS cord-011418-hy8xmtiq 178 31 's 's POS cord-011418-hy8xmtiq 178 32 hospital hospital NN cord-011418-hy8xmtiq 178 33 : : : cord-011418-hy8xmtiq 178 34 a a DT cord-011418-hy8xmtiq 178 35 prospective prospective JJ cord-011418-hy8xmtiq 178 36 cross cross JJ cord-011418-hy8xmtiq 178 37 - - JJ cord-011418-hy8xmtiq 178 38 sectional sectional JJ cord-011418-hy8xmtiq 178 39 survey survey NN cord-011418-hy8xmtiq 178 40 Ventilator Ventilator NNP cord-011418-hy8xmtiq 178 41 - - HYPH cord-011418-hy8xmtiq 178 42 associated associate VBN cord-011418-hy8xmtiq 178 43 lung lung NN cord-011418-hy8xmtiq 178 44 injury injury NN cord-011418-hy8xmtiq 178 45 Efficacy Efficacy NNP cord-011418-hy8xmtiq 178 46 and and CC cord-011418-hy8xmtiq 178 47 safety safety NN cord-011418-hy8xmtiq 178 48 of of IN cord-011418-hy8xmtiq 178 49 a a DT cord-011418-hy8xmtiq 178 50 paired paired JJ cord-011418-hy8xmtiq 178 51 sedation sedation NN cord-011418-hy8xmtiq 178 52 and and CC cord-011418-hy8xmtiq 178 53 ventilator ventilator NN cord-011418-hy8xmtiq 178 54 weaning wean VBG cord-011418-hy8xmtiq 178 55 protocol protocol NN cord-011418-hy8xmtiq 178 56 for for IN cord-011418-hy8xmtiq 178 57 mechanically mechanically RB cord-011418-hy8xmtiq 178 58 ventilated ventilate VBN cord-011418-hy8xmtiq 178 59 patients patient NNS cord-011418-hy8xmtiq 178 60 in in IN cord-011418-hy8xmtiq 178 61 intensive intensive JJ cord-011418-hy8xmtiq 178 62 care care NN cord-011418-hy8xmtiq 178 63 ( ( -LRB- cord-011418-hy8xmtiq 178 64 Awakening Awakening NNP cord-011418-hy8xmtiq 178 65 and and CC cord-011418-hy8xmtiq 178 66 Breathing Breathing NNP cord-011418-hy8xmtiq 178 67 Controlled Controlled NNP cord-011418-hy8xmtiq 178 68 trial trial NN cord-011418-hy8xmtiq 178 69 ) ) -RRB- cord-011418-hy8xmtiq 179 1 : : : cord-011418-hy8xmtiq 179 2 a a DT cord-011418-hy8xmtiq 179 3 randomised randomised JJ cord-011418-hy8xmtiq 179 4 controlled control VBN cord-011418-hy8xmtiq 179 5 trial trial NN cord-011418-hy8xmtiq 179 6 Effect effect NN cord-011418-hy8xmtiq 179 7 on on IN cord-011418-hy8xmtiq 179 8 the the DT cord-011418-hy8xmtiq 179 9 duration duration NN cord-011418-hy8xmtiq 179 10 of of IN cord-011418-hy8xmtiq 179 11 mechanical mechanical JJ cord-011418-hy8xmtiq 179 12 ventilation ventilation NN cord-011418-hy8xmtiq 179 13 of of IN cord-011418-hy8xmtiq 179 14 identifying identify VBG cord-011418-hy8xmtiq 179 15 patients patient NNS cord-011418-hy8xmtiq 179 16 capable capable JJ cord-011418-hy8xmtiq 179 17 of of IN cord-011418-hy8xmtiq 179 18 breathing breathe VBG cord-011418-hy8xmtiq 179 19 spontaneously spontaneously RB cord-011418-hy8xmtiq 179 20 Evidence evidence NN cord-011418-hy8xmtiq 179 21 - - HYPH cord-011418-hy8xmtiq 179 22 based base VBN cord-011418-hy8xmtiq 179 23 guidelines guideline NNS cord-011418-hy8xmtiq 179 24 for for IN cord-011418-hy8xmtiq 179 25 weaning wean VBG cord-011418-hy8xmtiq 179 26 and and CC cord-011418-hy8xmtiq 179 27 discontinuing discontinue VBG cord-011418-hy8xmtiq 179 28 ventilatory ventilatory JJ cord-011418-hy8xmtiq 179 29 support support NN cord-011418-hy8xmtiq 179 30 : : : cord-011418-hy8xmtiq 180 1 a a DT cord-011418-hy8xmtiq 180 2 collective collective JJ cord-011418-hy8xmtiq 180 3 task task NN cord-011418-hy8xmtiq 180 4 force force NN cord-011418-hy8xmtiq 180 5 facilitated facilitate VBN cord-011418-hy8xmtiq 180 6 by by IN cord-011418-hy8xmtiq 180 7 the the DT cord-011418-hy8xmtiq 180 8 American american JJ cord-011418-hy8xmtiq 180 9 college college NN cord-011418-hy8xmtiq 180 10 of of IN cord-011418-hy8xmtiq 180 11 chest chest NN cord-011418-hy8xmtiq 180 12 physicians physician NNS cord-011418-hy8xmtiq 180 13 ; ; : cord-011418-hy8xmtiq 180 14 the the DT cord-011418-hy8xmtiq 180 15 American american JJ cord-011418-hy8xmtiq 180 16 association association NN cord-011418-hy8xmtiq 180 17 for for IN cord-011418-hy8xmtiq 180 18 respiratory respiratory JJ cord-011418-hy8xmtiq 180 19 care care NN cord-011418-hy8xmtiq 180 20 ; ; : cord-011418-hy8xmtiq 180 21 and and CC cord-011418-hy8xmtiq 180 22 the the DT cord-011418-hy8xmtiq 180 23 American american JJ cord-011418-hy8xmtiq 180 24 college college NN cord-011418-hy8xmtiq 180 25 of of IN cord-011418-hy8xmtiq 180 26 critical critical JJ cord-011418-hy8xmtiq 180 27 medicine medicine NN cord-011418-hy8xmtiq 180 28 Early early RB cord-011418-hy8xmtiq 180 29 intensive intensive JJ cord-011418-hy8xmtiq 180 30 care care NN cord-011418-hy8xmtiq 180 31 sedation sedation NN cord-011418-hy8xmtiq 180 32 predicts predict VBZ cord-011418-hy8xmtiq 180 33 long long JJ cord-011418-hy8xmtiq 180 34 - - HYPH cord-011418-hy8xmtiq 180 35 term term NN cord-011418-hy8xmtiq 180 36 mortality mortality NN cord-011418-hy8xmtiq 180 37 in in IN cord-011418-hy8xmtiq 180 38 ventilated ventilate VBN cord-011418-hy8xmtiq 180 39 critically critically RB cord-011418-hy8xmtiq 180 40 ill ill JJ cord-011418-hy8xmtiq 180 41 patients patient NNS cord-011418-hy8xmtiq 180 42 Daily daily JJ cord-011418-hy8xmtiq 180 43 interruption interruption NN cord-011418-hy8xmtiq 180 44 of of IN cord-011418-hy8xmtiq 180 45 sedative sedative JJ cord-011418-hy8xmtiq 180 46 infusions infusion NNS cord-011418-hy8xmtiq 180 47 in in IN cord-011418-hy8xmtiq 180 48 critically critically RB cord-011418-hy8xmtiq 180 49 ill ill JJ cord-011418-hy8xmtiq 180 50 patients patient NNS cord-011418-hy8xmtiq 180 51 undergoing undergo VBG cord-011418-hy8xmtiq 180 52 mechanical mechanical JJ cord-011418-hy8xmtiq 180 53 ventilation ventilation NN cord-011418-hy8xmtiq 180 54 Practice practice NN cord-011418-hy8xmtiq 180 55 patterns pattern NNS cord-011418-hy8xmtiq 180 56 and and CC cord-011418-hy8xmtiq 180 57 outcomes outcome NNS cord-011418-hy8xmtiq 180 58 associated associate VBN cord-011418-hy8xmtiq 180 59 with with IN cord-011418-hy8xmtiq 180 60 early early JJ cord-011418-hy8xmtiq 180 61 sedation sedation NN cord-011418-hy8xmtiq 180 62 depth depth NN cord-011418-hy8xmtiq 180 63 in in IN cord-011418-hy8xmtiq 180 64 mechanically mechanically RB cord-011418-hy8xmtiq 180 65 ventilated ventilate VBN cord-011418-hy8xmtiq 180 66 patients patient NNS cord-011418-hy8xmtiq 180 67 : : : cord-011418-hy8xmtiq 181 1 a a DT cord-011418-hy8xmtiq 181 2 systematic systematic JJ cord-011418-hy8xmtiq 181 3 review review NN cord-011418-hy8xmtiq 181 4 and and CC cord-011418-hy8xmtiq 181 5 meta meta NNP cord-011418-hy8xmtiq 181 6 - - HYPH cord-011418-hy8xmtiq 181 7 analysis analysis NN cord-011418-hy8xmtiq 181 8 Analgosedation Analgosedation NNP cord-011418-hy8xmtiq 181 9 : : : cord-011418-hy8xmtiq 181 10 a a DT cord-011418-hy8xmtiq 181 11 paradigm paradigm NN cord-011418-hy8xmtiq 181 12 shift shift NN cord-011418-hy8xmtiq 181 13 in in IN cord-011418-hy8xmtiq 181 14 intensive intensive JJ cord-011418-hy8xmtiq 181 15 care care NN cord-011418-hy8xmtiq 181 16 unit unit NN cord-011418-hy8xmtiq 181 17 sedation sedation NN cord-011418-hy8xmtiq 181 18 practice practice VB cord-011418-hy8xmtiq 181 19 Validity validity NN cord-011418-hy8xmtiq 181 20 of of IN cord-011418-hy8xmtiq 181 21 the the DT cord-011418-hy8xmtiq 181 22 Richmond Richmond NNP cord-011418-hy8xmtiq 181 23 Agitation Agitation NNP cord-011418-hy8xmtiq 181 24 - - HYPH cord-011418-hy8xmtiq 181 25 Sedation sedation NN cord-011418-hy8xmtiq 181 26 Scale scale NN cord-011418-hy8xmtiq 181 27 ( ( -LRB- cord-011418-hy8xmtiq 181 28 RASS RASS NNP cord-011418-hy8xmtiq 181 29 ) ) -RRB- cord-011418-hy8xmtiq 181 30 in in IN cord-011418-hy8xmtiq 181 31 critically critically RB cord-011418-hy8xmtiq 181 32 ill ill JJ cord-011418-hy8xmtiq 181 33 children child NNS cord-011418-hy8xmtiq 181 34 Assessment Assessment NNP cord-011418-hy8xmtiq 181 35 of of IN cord-011418-hy8xmtiq 181 36 sedation sedation NN cord-011418-hy8xmtiq 181 37 levels level NNS cord-011418-hy8xmtiq 181 38 in in IN cord-011418-hy8xmtiq 181 39 pediatric pediatric JJ cord-011418-hy8xmtiq 181 40 intensive intensive JJ cord-011418-hy8xmtiq 181 41 care care NN cord-011418-hy8xmtiq 181 42 patients patient NNS cord-011418-hy8xmtiq 181 43 can can MD cord-011418-hy8xmtiq 181 44 be be VB cord-011418-hy8xmtiq 181 45 improved improve VBN cord-011418-hy8xmtiq 181 46 by by IN cord-011418-hy8xmtiq 181 47 using use VBG cord-011418-hy8xmtiq 181 48 the the DT cord-011418-hy8xmtiq 181 49 COMFORT COMFORT NNP cord-011418-hy8xmtiq 181 50 " " `` cord-011418-hy8xmtiq 181 51 behavior behavior NN cord-011418-hy8xmtiq 181 52 " " '' cord-011418-hy8xmtiq 181 53 scale scale NN cord-011418-hy8xmtiq 181 54 . . . cord-011418-hy8xmtiq 182 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 182 2 Crit Crit NNP cord-011418-hy8xmtiq 182 3 Care Care NNP cord-011418-hy8xmtiq 182 4 Med Med NNP cord-011418-hy8xmtiq 182 5 State State NNP cord-011418-hy8xmtiq 182 6 Behavioral Behavioral NNP cord-011418-hy8xmtiq 182 7 Scale scale NN cord-011418-hy8xmtiq 182 8 : : : cord-011418-hy8xmtiq 182 9 a a DT cord-011418-hy8xmtiq 182 10 sedation sedation NN cord-011418-hy8xmtiq 182 11 assessment assessment NN cord-011418-hy8xmtiq 182 12 instrument instrument NN cord-011418-hy8xmtiq 182 13 for for IN cord-011418-hy8xmtiq 182 14 infants infant NNS cord-011418-hy8xmtiq 182 15 and and CC cord-011418-hy8xmtiq 182 16 young young JJ cord-011418-hy8xmtiq 182 17 children child NNS cord-011418-hy8xmtiq 182 18 supported support VBN cord-011418-hy8xmtiq 182 19 on on IN cord-011418-hy8xmtiq 182 20 mechanical mechanical JJ cord-011418-hy8xmtiq 182 21 ventilation ventilation NN cord-011418-hy8xmtiq 182 22 . . . cord-011418-hy8xmtiq 183 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 183 2 Crit Crit NNP cord-011418-hy8xmtiq 183 3 Care Care NNP cord-011418-hy8xmtiq 183 4 Med Med NNP cord-011418-hy8xmtiq 183 5 Delirium delirium NN cord-011418-hy8xmtiq 183 6 and and CC cord-011418-hy8xmtiq 183 7 benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 183 8 associated associate VBN cord-011418-hy8xmtiq 183 9 with with IN cord-011418-hy8xmtiq 183 10 prolonged prolong VBN cord-011418-hy8xmtiq 183 11 ICU ICU NNP cord-011418-hy8xmtiq 183 12 stay stay VBP cord-011418-hy8xmtiq 183 13 in in IN cord-011418-hy8xmtiq 183 14 critically critically RB cord-011418-hy8xmtiq 183 15 ill ill JJ cord-011418-hy8xmtiq 183 16 infants infant NNS cord-011418-hy8xmtiq 183 17 and and CC cord-011418-hy8xmtiq 183 18 young young JJ cord-011418-hy8xmtiq 183 19 children child NNS cord-011418-hy8xmtiq 183 20 Benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 183 21 and and CC cord-011418-hy8xmtiq 183 22 development development NN cord-011418-hy8xmtiq 183 23 of of IN cord-011418-hy8xmtiq 183 24 delirium delirium NN cord-011418-hy8xmtiq 183 25 in in IN cord-011418-hy8xmtiq 184 1 critically critically RB cord-011418-hy8xmtiq 184 2 ill ill JJ cord-011418-hy8xmtiq 184 3 children child NNS cord-011418-hy8xmtiq 184 4 Dexmedetomidine Dexmedetomidine NNP cord-011418-hy8xmtiq 184 5 improves improve VBZ cord-011418-hy8xmtiq 184 6 the the DT cord-011418-hy8xmtiq 184 7 outcomes outcome NNS cord-011418-hy8xmtiq 184 8 in in IN cord-011418-hy8xmtiq 184 9 paediatric paediatric JJ cord-011418-hy8xmtiq 184 10 cardiac cardiac JJ cord-011418-hy8xmtiq 184 11 surgery surgery NN cord-011418-hy8xmtiq 184 12 : : : cord-011418-hy8xmtiq 184 13 a a DT cord-011418-hy8xmtiq 184 14 metaanalysis metaanalysis NN cord-011418-hy8xmtiq 184 15 of of IN cord-011418-hy8xmtiq 184 16 randomized randomized JJ cord-011418-hy8xmtiq 184 17 controlled control VBN cord-011418-hy8xmtiq 184 18 trials trial NNS cord-011418-hy8xmtiq 184 19 Outcomes outcome NNS cord-011418-hy8xmtiq 184 20 of of IN cord-011418-hy8xmtiq 184 21 dexmedetomidine dexmedetomidine JJ cord-011418-hy8xmtiq 184 22 treatment treatment NN cord-011418-hy8xmtiq 184 23 in in IN cord-011418-hy8xmtiq 184 24 pediatric pediatric JJ cord-011418-hy8xmtiq 184 25 patients patient NNS cord-011418-hy8xmtiq 184 26 undergoing undergo VBG cord-011418-hy8xmtiq 184 27 congenital congenital JJ cord-011418-hy8xmtiq 184 28 heart heart NN cord-011418-hy8xmtiq 184 29 disease disease NN cord-011418-hy8xmtiq 184 30 surgery surgery NN cord-011418-hy8xmtiq 184 31 : : : cord-011418-hy8xmtiq 184 32 a a DT cord-011418-hy8xmtiq 184 33 meta meta NNP cord-011418-hy8xmtiq 184 34 - - HYPH cord-011418-hy8xmtiq 184 35 Analysis Analysis NNP cord-011418-hy8xmtiq 184 36 Long long JJ cord-011418-hy8xmtiq 184 37 - - HYPH cord-011418-hy8xmtiq 184 38 term term NN cord-011418-hy8xmtiq 184 39 outcomes outcome NNS cord-011418-hy8xmtiq 184 40 after after IN cord-011418-hy8xmtiq 184 41 protocolized protocolized JJ cord-011418-hy8xmtiq 184 42 sedation sedation NN cord-011418-hy8xmtiq 184 43 versus versus IN cord-011418-hy8xmtiq 184 44 usual usual JJ cord-011418-hy8xmtiq 184 45 care care NN cord-011418-hy8xmtiq 184 46 in in IN cord-011418-hy8xmtiq 185 1 ventilated ventilate VBN cord-011418-hy8xmtiq 185 2 pediatric pediatric JJ cord-011418-hy8xmtiq 185 3 patients patient NNS cord-011418-hy8xmtiq 185 4 Implementation Implementation NNP cord-011418-hy8xmtiq 185 5 of of IN cord-011418-hy8xmtiq 185 6 a a DT cord-011418-hy8xmtiq 185 7 nurse nurse NN cord-011418-hy8xmtiq 185 8 - - HYPH cord-011418-hy8xmtiq 185 9 driven drive VBN cord-011418-hy8xmtiq 185 10 sedation sedation NN cord-011418-hy8xmtiq 185 11 protocol protocol NN cord-011418-hy8xmtiq 185 12 in in IN cord-011418-hy8xmtiq 185 13 a a DT cord-011418-hy8xmtiq 185 14 PICU PICU NNP cord-011418-hy8xmtiq 185 15 decreases decrease VBZ cord-011418-hy8xmtiq 185 16 daily daily JJ cord-011418-hy8xmtiq 185 17 doses dose NNS cord-011418-hy8xmtiq 185 18 of of IN cord-011418-hy8xmtiq 185 19 midazolam midazolam NNP cord-011418-hy8xmtiq 185 20 . . . cord-011418-hy8xmtiq 186 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 186 2 Crit Crit NNP cord-011418-hy8xmtiq 186 3 Care Care NNP cord-011418-hy8xmtiq 186 4 Med Med NNP cord-011418-hy8xmtiq 186 5 Nurse nurse NN cord-011418-hy8xmtiq 186 6 - - HYPH cord-011418-hy8xmtiq 186 7 driven drive VBN cord-011418-hy8xmtiq 186 8 pediatric pediatric JJ cord-011418-hy8xmtiq 186 9 analgesia analgesia NN cord-011418-hy8xmtiq 186 10 and and CC cord-011418-hy8xmtiq 186 11 sedation sedation NN cord-011418-hy8xmtiq 186 12 protocol protocol NN cord-011418-hy8xmtiq 186 13 reduces reduce VBZ cord-011418-hy8xmtiq 186 14 withdrawal withdrawal NN cord-011418-hy8xmtiq 186 15 symptoms symptom NNS cord-011418-hy8xmtiq 186 16 in in IN cord-011418-hy8xmtiq 186 17 critically critically RB cord-011418-hy8xmtiq 186 18 ill ill JJ cord-011418-hy8xmtiq 186 19 medical medical JJ cord-011418-hy8xmtiq 186 20 pediatric pediatric JJ cord-011418-hy8xmtiq 186 21 patients patient NNS cord-011418-hy8xmtiq 186 22 Delirium Delirium NNP cord-011418-hy8xmtiq 186 23 in in IN cord-011418-hy8xmtiq 186 24 critically critically RB cord-011418-hy8xmtiq 186 25 ill ill JJ cord-011418-hy8xmtiq 186 26 children child NNS cord-011418-hy8xmtiq 186 27 : : : cord-011418-hy8xmtiq 186 28 an an DT cord-011418-hy8xmtiq 186 29 international international JJ cord-011418-hy8xmtiq 186 30 point point NN cord-011418-hy8xmtiq 186 31 prevalence prevalence NN cord-011418-hy8xmtiq 186 32 study study NN cord-011418-hy8xmtiq 186 33 * * NFP cord-011418-hy8xmtiq 186 34 Diagnosing diagnose VBG cord-011418-hy8xmtiq 186 35 delirium delirium NN cord-011418-hy8xmtiq 186 36 in in IN cord-011418-hy8xmtiq 186 37 critically critically RB cord-011418-hy8xmtiq 186 38 ill ill JJ cord-011418-hy8xmtiq 186 39 children child NNS cord-011418-hy8xmtiq 186 40 : : : cord-011418-hy8xmtiq 186 41 validity validity NN cord-011418-hy8xmtiq 186 42 and and CC cord-011418-hy8xmtiq 186 43 reliability reliability NN cord-011418-hy8xmtiq 186 44 of of IN cord-011418-hy8xmtiq 186 45 the the DT cord-011418-hy8xmtiq 186 46 Pediatric Pediatric NNP cord-011418-hy8xmtiq 186 47 Confusion Confusion NNP cord-011418-hy8xmtiq 186 48 Assessment Assessment NNP cord-011418-hy8xmtiq 186 49 Method Method NNP cord-011418-hy8xmtiq 186 50 for for IN cord-011418-hy8xmtiq 186 51 the the DT cord-011418-hy8xmtiq 186 52 Intensive Intensive NNP cord-011418-hy8xmtiq 186 53 Care Care NNP cord-011418-hy8xmtiq 186 54 Unit Unit NNP cord-011418-hy8xmtiq 187 1 The the DT cord-011418-hy8xmtiq 187 2 Preschool Preschool NNP cord-011418-hy8xmtiq 187 3 Confusion Confusion NNP cord-011418-hy8xmtiq 187 4 Assessment Assessment NNP cord-011418-hy8xmtiq 187 5 Method Method NNP cord-011418-hy8xmtiq 187 6 for for IN cord-011418-hy8xmtiq 187 7 the the DT cord-011418-hy8xmtiq 187 8 ICU ICU NNP cord-011418-hy8xmtiq 187 9 Delirium Delirium NNP cord-011418-hy8xmtiq 187 10 is be VBZ cord-011418-hy8xmtiq 187 11 a a DT cord-011418-hy8xmtiq 187 12 common common JJ cord-011418-hy8xmtiq 187 13 and and CC cord-011418-hy8xmtiq 187 14 early early JJ cord-011418-hy8xmtiq 187 15 finding finding NN cord-011418-hy8xmtiq 187 16 in in IN cord-011418-hy8xmtiq 187 17 patients patient NNS cord-011418-hy8xmtiq 187 18 in in IN cord-011418-hy8xmtiq 187 19 the the DT cord-011418-hy8xmtiq 187 20 pediatric pediatric JJ cord-011418-hy8xmtiq 187 21 cardiac cardiac JJ cord-011418-hy8xmtiq 187 22 intensive intensive JJ cord-011418-hy8xmtiq 187 23 care care NN cord-011418-hy8xmtiq 187 24 unit unit NN cord-011418-hy8xmtiq 187 25 Delirium Delirium NNP cord-011418-hy8xmtiq 187 26 in in IN cord-011418-hy8xmtiq 187 27 children child NNS cord-011418-hy8xmtiq 187 28 after after IN cord-011418-hy8xmtiq 187 29 cardiac cardiac JJ cord-011418-hy8xmtiq 187 30 bypass bypass NN cord-011418-hy8xmtiq 187 31 surgery surgery NN cord-011418-hy8xmtiq 187 32 Delirium delirium NN cord-011418-hy8xmtiq 187 33 in in IN cord-011418-hy8xmtiq 187 34 the the DT cord-011418-hy8xmtiq 187 35 pediatric pediatric JJ cord-011418-hy8xmtiq 187 36 cardiac cardiac JJ cord-011418-hy8xmtiq 187 37 extracorporeal extracorporeal NN cord-011418-hy8xmtiq 187 38 membrane membrane NN cord-011418-hy8xmtiq 187 39 oxygenation oxygenation NN cord-011418-hy8xmtiq 187 40 patient patient NN cord-011418-hy8xmtiq 187 41 population population NN cord-011418-hy8xmtiq 187 42 : : : cord-011418-hy8xmtiq 188 1 a a DT cord-011418-hy8xmtiq 188 2 case case NN cord-011418-hy8xmtiq 188 3 series series NN cord-011418-hy8xmtiq 188 4 Cost cost NN cord-011418-hy8xmtiq 188 5 associated associate VBN cord-011418-hy8xmtiq 188 6 with with IN cord-011418-hy8xmtiq 188 7 pediatric pediatric JJ cord-011418-hy8xmtiq 188 8 delirium delirium NN cord-011418-hy8xmtiq 188 9 in in IN cord-011418-hy8xmtiq 188 10 the the DT cord-011418-hy8xmtiq 188 11 ICU ICU NNP cord-011418-hy8xmtiq 188 12 Patterns pattern NNS cord-011418-hy8xmtiq 188 13 of of IN cord-011418-hy8xmtiq 188 14 postoperative postoperative JJ cord-011418-hy8xmtiq 188 15 delirium delirium NN cord-011418-hy8xmtiq 188 16 in in IN cord-011418-hy8xmtiq 188 17 children child NNS cord-011418-hy8xmtiq 188 18 * * NFP cord-011418-hy8xmtiq 188 19 Delirium delirium NN cord-011418-hy8xmtiq 188 20 and and CC cord-011418-hy8xmtiq 188 21 mortality mortality NN cord-011418-hy8xmtiq 188 22 in in IN cord-011418-hy8xmtiq 188 23 critically critically RB cord-011418-hy8xmtiq 188 24 ill ill JJ cord-011418-hy8xmtiq 188 25 children child NNS cord-011418-hy8xmtiq 188 26 Cornell Cornell NNP cord-011418-hy8xmtiq 188 27 assessment assessment NN cord-011418-hy8xmtiq 188 28 of of IN cord-011418-hy8xmtiq 188 29 pediatric pediatric JJ cord-011418-hy8xmtiq 188 30 delirium delirium NN cord-011418-hy8xmtiq 188 31 Construction construction NN cord-011418-hy8xmtiq 188 32 of of IN cord-011418-hy8xmtiq 188 33 the the DT cord-011418-hy8xmtiq 188 34 Sophia Sophia NNP cord-011418-hy8xmtiq 188 35 Observation Observation NNP cord-011418-hy8xmtiq 188 36 withdrawal withdrawal NN cord-011418-hy8xmtiq 188 37 Symptomsscale Symptomsscale NNP cord-011418-hy8xmtiq 188 38 ( ( -LRB- cord-011418-hy8xmtiq 188 39 SOS SOS NNP cord-011418-hy8xmtiq 188 40 ) ) -RRB- cord-011418-hy8xmtiq 188 41 for for IN cord-011418-hy8xmtiq 188 42 critically critically RB cord-011418-hy8xmtiq 188 43 ill ill JJ cord-011418-hy8xmtiq 188 44 children child NNS cord-011418-hy8xmtiq 188 45 Benzodiazepines benzodiazepine NNS cord-011418-hy8xmtiq 188 46 and and CC cord-011418-hy8xmtiq 188 47 development development NN cord-011418-hy8xmtiq 188 48 of of IN cord-011418-hy8xmtiq 188 49 delirium delirium NN cord-011418-hy8xmtiq 188 50 in in IN cord-011418-hy8xmtiq 188 51 critically critically RB cord-011418-hy8xmtiq 188 52 ill ill JJ cord-011418-hy8xmtiq 188 53 children child NNS cord-011418-hy8xmtiq 188 54 : : : cord-011418-hy8xmtiq 188 55 estimating estimate VBG cord-011418-hy8xmtiq 188 56 the the DT cord-011418-hy8xmtiq 188 57 causal causal JJ cord-011418-hy8xmtiq 188 58 effect effect NN cord-011418-hy8xmtiq 188 59 Delirium delirium NN cord-011418-hy8xmtiq 188 60 in in IN cord-011418-hy8xmtiq 188 61 the the DT cord-011418-hy8xmtiq 188 62 pediatric pediatric JJ cord-011418-hy8xmtiq 188 63 hematology hematology NN cord-011418-hy8xmtiq 188 64 , , , cord-011418-hy8xmtiq 188 65 oncology oncology NN cord-011418-hy8xmtiq 188 66 , , , cord-011418-hy8xmtiq 188 67 and and CC cord-011418-hy8xmtiq 188 68 bone bone NN cord-011418-hy8xmtiq 188 69 marrow marrow NN cord-011418-hy8xmtiq 188 70 transplant transplant NN cord-011418-hy8xmtiq 188 71 population population NN cord-011418-hy8xmtiq 188 72 . . . cord-011418-hy8xmtiq 189 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 189 2 Blood Blood NNP cord-011418-hy8xmtiq 189 3 Cancer Cancer NNP cord-011418-hy8xmtiq 189 4 Anticholinergic Anticholinergic NNP cord-011418-hy8xmtiq 189 5 medication medication NN cord-011418-hy8xmtiq 189 6 burden burden NN cord-011418-hy8xmtiq 189 7 in in IN cord-011418-hy8xmtiq 189 8 pediatric pediatric JJ cord-011418-hy8xmtiq 189 9 prolonged prolonged JJ cord-011418-hy8xmtiq 189 10 critical critical JJ cord-011418-hy8xmtiq 189 11 illness illness NN cord-011418-hy8xmtiq 189 12 : : : cord-011418-hy8xmtiq 189 13 a a DT cord-011418-hy8xmtiq 189 14 potentially potentially RB cord-011418-hy8xmtiq 189 15 modifiable modifiable JJ cord-011418-hy8xmtiq 189 16 risk risk NN cord-011418-hy8xmtiq 189 17 factor factor NN cord-011418-hy8xmtiq 189 18 for for IN cord-011418-hy8xmtiq 189 19 delirium delirium NN cord-011418-hy8xmtiq 189 20 . . . cord-011418-hy8xmtiq 190 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 190 2 Crit Crit NNP cord-011418-hy8xmtiq 190 3 Care Care NNP cord-011418-hy8xmtiq 190 4 Med Med NNP cord-011418-hy8xmtiq 190 5 Association Association NNP cord-011418-hy8xmtiq 190 6 between between IN cord-011418-hy8xmtiq 190 7 transfusion transfusion NN cord-011418-hy8xmtiq 190 8 of of IN cord-011418-hy8xmtiq 190 9 RBCs rbc NNS cord-011418-hy8xmtiq 190 10 and and CC cord-011418-hy8xmtiq 190 11 subsequent subsequent JJ cord-011418-hy8xmtiq 190 12 development development NN cord-011418-hy8xmtiq 190 13 of of IN cord-011418-hy8xmtiq 190 14 delirium delirium NN cord-011418-hy8xmtiq 190 15 in in IN cord-011418-hy8xmtiq 190 16 critically critically RB cord-011418-hy8xmtiq 190 17 ill ill JJ cord-011418-hy8xmtiq 190 18 children child NNS cord-011418-hy8xmtiq 190 19 Haloperidol Haloperidol NNP cord-011418-hy8xmtiq 190 20 and and CC cord-011418-hy8xmtiq 190 21 ziprasidone ziprasidone NN cord-011418-hy8xmtiq 190 22 for for IN cord-011418-hy8xmtiq 190 23 treatment treatment NN cord-011418-hy8xmtiq 190 24 of of IN cord-011418-hy8xmtiq 190 25 delirium delirium NN cord-011418-hy8xmtiq 190 26 in in IN cord-011418-hy8xmtiq 190 27 critical critical JJ cord-011418-hy8xmtiq 190 28 illness illness NN cord-011418-hy8xmtiq 190 29 Evaluation Evaluation NNP cord-011418-hy8xmtiq 190 30 of of IN cord-011418-hy8xmtiq 190 31 the the DT cord-011418-hy8xmtiq 190 32 safety safety NN cord-011418-hy8xmtiq 190 33 of of IN cord-011418-hy8xmtiq 190 34 quetiapine quetiapine NNP cord-011418-hy8xmtiq 190 35 in in IN cord-011418-hy8xmtiq 190 36 treating treat VBG cord-011418-hy8xmtiq 190 37 delirium delirium NN cord-011418-hy8xmtiq 190 38 in in IN cord-011418-hy8xmtiq 190 39 critically critically RB cord-011418-hy8xmtiq 190 40 ill ill JJ cord-011418-hy8xmtiq 190 41 children child NNS cord-011418-hy8xmtiq 190 42 : : : cord-011418-hy8xmtiq 190 43 a a DT cord-011418-hy8xmtiq 190 44 retrospective retrospective JJ cord-011418-hy8xmtiq 190 45 review review NN cord-011418-hy8xmtiq 191 1 An an DT cord-011418-hy8xmtiq 191 2 evaluation evaluation NN cord-011418-hy8xmtiq 191 3 of of IN cord-011418-hy8xmtiq 191 4 risperidone risperidone NNP cord-011418-hy8xmtiq 191 5 dosing dose VBG cord-011418-hy8xmtiq 191 6 for for IN cord-011418-hy8xmtiq 191 7 pediatric pediatric JJ cord-011418-hy8xmtiq 191 8 delirium delirium NN cord-011418-hy8xmtiq 191 9 in in IN cord-011418-hy8xmtiq 191 10 children child NNS cord-011418-hy8xmtiq 191 11 less less RBR cord-011418-hy8xmtiq 191 12 than than IN cord-011418-hy8xmtiq 191 13 or or CC cord-011418-hy8xmtiq 191 14 equal equal JJ cord-011418-hy8xmtiq 191 15 to to IN cord-011418-hy8xmtiq 191 16 2 2 CD cord-011418-hy8xmtiq 191 17 years year NNS cord-011418-hy8xmtiq 191 18 of of IN cord-011418-hy8xmtiq 191 19 age age NN cord-011418-hy8xmtiq 191 20 Antipsychotic antipsychotic JJ cord-011418-hy8xmtiq 191 21 treatment treatment NN cord-011418-hy8xmtiq 191 22 of of IN cord-011418-hy8xmtiq 191 23 delirium delirium NN cord-011418-hy8xmtiq 191 24 in in IN cord-011418-hy8xmtiq 191 25 critically critically RB cord-011418-hy8xmtiq 191 26 Ill ill JJ cord-011418-hy8xmtiq 191 27 children child NNS cord-011418-hy8xmtiq 191 28 : : : cord-011418-hy8xmtiq 192 1 a a DT cord-011418-hy8xmtiq 192 2 retrospective retrospective JJ cord-011418-hy8xmtiq 192 3 matched match VBN cord-011418-hy8xmtiq 192 4 cohort cohort NN cord-011418-hy8xmtiq 192 5 study study NN cord-011418-hy8xmtiq 192 6 Olanzapine Olanzapine NNP cord-011418-hy8xmtiq 192 7 reduces reduce VBZ cord-011418-hy8xmtiq 192 8 delirium delirium NN cord-011418-hy8xmtiq 192 9 symptoms symptom NNS cord-011418-hy8xmtiq 192 10 in in IN cord-011418-hy8xmtiq 192 11 the the DT cord-011418-hy8xmtiq 192 12 critically critically RB cord-011418-hy8xmtiq 192 13 ill ill JJ cord-011418-hy8xmtiq 192 14 pediatric pediatric JJ cord-011418-hy8xmtiq 192 15 patient patient NN cord-011418-hy8xmtiq 192 16 Intensive Intensive NNP cord-011418-hy8xmtiq 192 17 care care NN cord-011418-hy8xmtiq 192 18 unit unit NN cord-011418-hy8xmtiq 192 19 - - HYPH cord-011418-hy8xmtiq 192 20 acquired acquire VBN cord-011418-hy8xmtiq 192 21 weakness weakness NN cord-011418-hy8xmtiq 192 22 ICU ICU NNP cord-011418-hy8xmtiq 192 23 - - HYPH cord-011418-hy8xmtiq 192 24 acquired acquire VBN cord-011418-hy8xmtiq 192 25 weakness weakness NN cord-011418-hy8xmtiq 192 26 ICU ICU NNP cord-011418-hy8xmtiq 192 27 - - HYPH cord-011418-hy8xmtiq 192 28 acquired acquire VBN cord-011418-hy8xmtiq 192 29 weakness weakness NN cord-011418-hy8xmtiq 192 30 and and CC cord-011418-hy8xmtiq 192 31 recovery recovery NN cord-011418-hy8xmtiq 192 32 from from IN cord-011418-hy8xmtiq 192 33 critical critical JJ cord-011418-hy8xmtiq 192 34 illness illness NN cord-011418-hy8xmtiq 192 35 Intensive Intensive NNP cord-011418-hy8xmtiq 192 36 care care NN cord-011418-hy8xmtiq 192 37 unit unit NN cord-011418-hy8xmtiq 192 38 acquired acquire VBD cord-011418-hy8xmtiq 192 39 weakness weakness NN cord-011418-hy8xmtiq 192 40 in in IN cord-011418-hy8xmtiq 192 41 children child NNS cord-011418-hy8xmtiq 192 42 : : : cord-011418-hy8xmtiq 193 1 critical critical JJ cord-011418-hy8xmtiq 193 2 illness illness NN cord-011418-hy8xmtiq 193 3 polyneuropathy polyneuropathy NN cord-011418-hy8xmtiq 193 4 and and CC cord-011418-hy8xmtiq 193 5 myopathy myopathy NN cord-011418-hy8xmtiq 193 6 ICU ICU NNP cord-011418-hy8xmtiq 193 7 - - HYPH cord-011418-hy8xmtiq 193 8 acquired acquire VBN cord-011418-hy8xmtiq 193 9 weakness weakness NN cord-011418-hy8xmtiq 193 10 is be VBZ cord-011418-hy8xmtiq 193 11 associated associate VBN cord-011418-hy8xmtiq 193 12 with with IN cord-011418-hy8xmtiq 193 13 differences difference NNS cord-011418-hy8xmtiq 193 14 in in IN cord-011418-hy8xmtiq 193 15 clinical clinical JJ cord-011418-hy8xmtiq 193 16 outcomes outcome NNS cord-011418-hy8xmtiq 193 17 in in IN cord-011418-hy8xmtiq 193 18 critically critically RB cord-011418-hy8xmtiq 193 19 ill ill JJ cord-011418-hy8xmtiq 193 20 children child NNS cord-011418-hy8xmtiq 193 21 . . . cord-011418-hy8xmtiq 194 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 194 2 Crit Crit NNP cord-011418-hy8xmtiq 194 3 Care Care NNP cord-011418-hy8xmtiq 194 4 Med Med NNP cord-011418-hy8xmtiq 194 5 Muscle Muscle NNP cord-011418-hy8xmtiq 194 6 weakness weakness NN cord-011418-hy8xmtiq 194 7 in in IN cord-011418-hy8xmtiq 194 8 critically critically RB cord-011418-hy8xmtiq 194 9 ill ill JJ cord-011418-hy8xmtiq 194 10 children child NNS cord-011418-hy8xmtiq 195 1 Thigh thigh NN cord-011418-hy8xmtiq 195 2 ultrasound ultrasound NN cord-011418-hy8xmtiq 195 3 monitoring monitoring NN cord-011418-hy8xmtiq 195 4 identifies identify VBZ cord-011418-hy8xmtiq 195 5 decreases decrease NNS cord-011418-hy8xmtiq 195 6 in in IN cord-011418-hy8xmtiq 195 7 quadriceps quadriceps NN cord-011418-hy8xmtiq 195 8 femoris femoris NN cord-011418-hy8xmtiq 195 9 thickness thickness NN cord-011418-hy8xmtiq 195 10 as as IN cord-011418-hy8xmtiq 195 11 a a DT cord-011418-hy8xmtiq 195 12 frequent frequent JJ cord-011418-hy8xmtiq 195 13 observation observation NN cord-011418-hy8xmtiq 195 14 in in IN cord-011418-hy8xmtiq 195 15 critically critically RB cord-011418-hy8xmtiq 195 16 ill ill JJ cord-011418-hy8xmtiq 195 17 children child NNS cord-011418-hy8xmtiq 195 18 . . . cord-011418-hy8xmtiq 196 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 196 2 Crit Crit NNP cord-011418-hy8xmtiq 196 3 Care Care NNP cord-011418-hy8xmtiq 196 4 Med Med NNP cord-011418-hy8xmtiq 196 5 Bench Bench NNP cord-011418-hy8xmtiq 196 6 - - HYPH cord-011418-hy8xmtiq 196 7 to to IN cord-011418-hy8xmtiq 196 8 - - HYPH cord-011418-hy8xmtiq 196 9 bedside bedside NN cord-011418-hy8xmtiq 196 10 review review NN cord-011418-hy8xmtiq 196 11 : : : cord-011418-hy8xmtiq 196 12 mobilizing mobilize VBG cord-011418-hy8xmtiq 196 13 patients patient NNS cord-011418-hy8xmtiq 196 14 in in IN cord-011418-hy8xmtiq 196 15 the the DT cord-011418-hy8xmtiq 196 16 intensive intensive JJ cord-011418-hy8xmtiq 196 17 care care NN cord-011418-hy8xmtiq 196 18 unit unit NN cord-011418-hy8xmtiq 196 19 -from -from IN cord-011418-hy8xmtiq 196 20 pathophysiology pathophysiology NN cord-011418-hy8xmtiq 196 21 to to IN cord-011418-hy8xmtiq 196 22 clinical clinical JJ cord-011418-hy8xmtiq 196 23 trials trial NNS cord-011418-hy8xmtiq 196 24 Impact Impact NNP cord-011418-hy8xmtiq 196 25 of of IN cord-011418-hy8xmtiq 196 26 very very RB cord-011418-hy8xmtiq 196 27 early early JJ cord-011418-hy8xmtiq 196 28 physical physical JJ cord-011418-hy8xmtiq 196 29 therapy therapy NN cord-011418-hy8xmtiq 196 30 during during IN cord-011418-hy8xmtiq 196 31 septic septic JJ cord-011418-hy8xmtiq 196 32 shock shock NN cord-011418-hy8xmtiq 196 33 on on IN cord-011418-hy8xmtiq 196 34 skeletal skeletal JJ cord-011418-hy8xmtiq 196 35 muscle muscle NN cord-011418-hy8xmtiq 196 36 Early early JJ cord-011418-hy8xmtiq 196 37 physical physical JJ cord-011418-hy8xmtiq 196 38 medicine medicine NN cord-011418-hy8xmtiq 196 39 and and CC cord-011418-hy8xmtiq 196 40 rehabilitation rehabilitation NN cord-011418-hy8xmtiq 196 41 for for IN cord-011418-hy8xmtiq 196 42 patients patient NNS cord-011418-hy8xmtiq 196 43 with with IN cord-011418-hy8xmtiq 196 44 acute acute JJ cord-011418-hy8xmtiq 196 45 respiratory respiratory JJ cord-011418-hy8xmtiq 196 46 failure failure NN cord-011418-hy8xmtiq 196 47 : : : cord-011418-hy8xmtiq 196 48 a a DT cord-011418-hy8xmtiq 196 49 quality quality NN cord-011418-hy8xmtiq 196 50 improvement improvement NN cord-011418-hy8xmtiq 196 51 project project NN cord-011418-hy8xmtiq 196 52 Early early JJ cord-011418-hy8xmtiq 196 53 physical physical JJ cord-011418-hy8xmtiq 196 54 and and CC cord-011418-hy8xmtiq 196 55 occupational occupational JJ cord-011418-hy8xmtiq 196 56 therapy therapy NN cord-011418-hy8xmtiq 196 57 in in IN cord-011418-hy8xmtiq 196 58 mechanically mechanically RB cord-011418-hy8xmtiq 196 59 ventilated ventilate VBN cord-011418-hy8xmtiq 196 60 , , , cord-011418-hy8xmtiq 196 61 critically critically RB cord-011418-hy8xmtiq 196 62 ill ill JJ cord-011418-hy8xmtiq 196 63 patients patient NNS cord-011418-hy8xmtiq 197 1 : : : cord-011418-hy8xmtiq 197 2 a a DT cord-011418-hy8xmtiq 197 3 randomised randomised JJ cord-011418-hy8xmtiq 197 4 controlled control VBN cord-011418-hy8xmtiq 197 5 trial trial NN cord-011418-hy8xmtiq 197 6 Goal Goal NNP cord-011418-hy8xmtiq 197 7 directed direct VBD cord-011418-hy8xmtiq 197 8 early early JJ cord-011418-hy8xmtiq 197 9 mobilization mobilization NN cord-011418-hy8xmtiq 197 10 reduces reduce VBZ cord-011418-hy8xmtiq 197 11 ICU ICU NNP cord-011418-hy8xmtiq 197 12 length length NN cord-011418-hy8xmtiq 197 13 of of IN cord-011418-hy8xmtiq 197 14 stay stay NN cord-011418-hy8xmtiq 197 15 and and CC cord-011418-hy8xmtiq 197 16 improves improve VBZ cord-011418-hy8xmtiq 197 17 functional functional JJ cord-011418-hy8xmtiq 197 18 mobility mobility NN cord-011418-hy8xmtiq 197 19 : : : cord-011418-hy8xmtiq 197 20 an an DT cord-011418-hy8xmtiq 197 21 international international JJ cord-011418-hy8xmtiq 197 22 multi multi JJ cord-011418-hy8xmtiq 197 23 center center NN cord-011418-hy8xmtiq 197 24 , , , cord-011418-hy8xmtiq 197 25 randomized randomized JJ cord-011418-hy8xmtiq 197 26 , , , cord-011418-hy8xmtiq 197 27 controlled control VBN cord-011418-hy8xmtiq 197 28 trial trial NN cord-011418-hy8xmtiq 197 29 ( ( -LRB- cord-011418-hy8xmtiq 197 30 Soms Soms NNP cord-011418-hy8xmtiq 197 31 Trial Trial NNP cord-011418-hy8xmtiq 197 32 ) ) -RRB- cord-011418-hy8xmtiq 197 33 Preventing prevent VBG cord-011418-hy8xmtiq 197 34 ICU ICU NNP cord-011418-hy8xmtiq 197 35 subsyndromal subsyndromal NNP cord-011418-hy8xmtiq 197 36 delirium delirium NN cord-011418-hy8xmtiq 197 37 conversion conversion NN cord-011418-hy8xmtiq 197 38 to to IN cord-011418-hy8xmtiq 197 39 delirium delirium NN cord-011418-hy8xmtiq 197 40 with with IN cord-011418-hy8xmtiq 197 41 low low JJ cord-011418-hy8xmtiq 197 42 - - HYPH cord-011418-hy8xmtiq 197 43 dose dose NN cord-011418-hy8xmtiq 197 44 IV IV NNP cord-011418-hy8xmtiq 197 45 haloperidol haloperidol NNP cord-011418-hy8xmtiq 197 46 : : : cord-011418-hy8xmtiq 197 47 a a DT cord-011418-hy8xmtiq 197 48 doubleblind doubleblind NN cord-011418-hy8xmtiq 197 49 , , , cord-011418-hy8xmtiq 197 50 placebo placebo NN cord-011418-hy8xmtiq 197 51 - - HYPH cord-011418-hy8xmtiq 197 52 controlled control VBN cord-011418-hy8xmtiq 197 53 pilot pilot NN cord-011418-hy8xmtiq 197 54 study study NN cord-011418-hy8xmtiq 197 55 Development Development NNP cord-011418-hy8xmtiq 197 56 and and CC cord-011418-hy8xmtiq 197 57 implementation implementation NN cord-011418-hy8xmtiq 197 58 of of IN cord-011418-hy8xmtiq 197 59 an an DT cord-011418-hy8xmtiq 197 60 early early JJ cord-011418-hy8xmtiq 197 61 mobility mobility NN cord-011418-hy8xmtiq 197 62 program program NN cord-011418-hy8xmtiq 197 63 for for IN cord-011418-hy8xmtiq 197 64 mechanically mechanically RB cord-011418-hy8xmtiq 197 65 ventilated ventilate VBN cord-011418-hy8xmtiq 197 66 pediatric pediatric JJ cord-011418-hy8xmtiq 197 67 patients patient NNS cord-011418-hy8xmtiq 197 68 Changes change NNS cord-011418-hy8xmtiq 197 69 in in IN cord-011418-hy8xmtiq 197 70 provider provider NN cord-011418-hy8xmtiq 197 71 perceptions perception NNS cord-011418-hy8xmtiq 197 72 regarding regard VBG cord-011418-hy8xmtiq 197 73 early early JJ cord-011418-hy8xmtiq 197 74 mobility mobility NN cord-011418-hy8xmtiq 197 75 in in IN cord-011418-hy8xmtiq 197 76 the the DT cord-011418-hy8xmtiq 197 77 PICU PICU NNP cord-011418-hy8xmtiq 197 78 . . . cord-011418-hy8xmtiq 198 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 198 2 Crit Crit NNP cord-011418-hy8xmtiq 198 3 Care Care NNP cord-011418-hy8xmtiq 198 4 Med Med NNP cord-011418-hy8xmtiq 198 5 Early early JJ cord-011418-hy8xmtiq 198 6 mobilization mobilization NN cord-011418-hy8xmtiq 198 7 in in IN cord-011418-hy8xmtiq 198 8 critically critically RB cord-011418-hy8xmtiq 198 9 ill ill JJ cord-011418-hy8xmtiq 198 10 children child NNS cord-011418-hy8xmtiq 198 11 : : : cord-011418-hy8xmtiq 199 1 a a DT cord-011418-hy8xmtiq 199 2 systematic systematic JJ cord-011418-hy8xmtiq 199 3 review review NN cord-011418-hy8xmtiq 199 4 PICU PICU NNP cord-011418-hy8xmtiq 199 5 up up RP cord-011418-hy8xmtiq 199 6 ! ! . cord-011418-hy8xmtiq 200 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 200 2 Crit Crit NNP cord-011418-hy8xmtiq 200 3 Care Care NNP cord-011418-hy8xmtiq 200 4 Med Med NNP cord-011418-hy8xmtiq 200 5 Early early JJ cord-011418-hy8xmtiq 200 6 exercise exercise NN cord-011418-hy8xmtiq 200 7 in in IN cord-011418-hy8xmtiq 200 8 critically critically RB cord-011418-hy8xmtiq 200 9 ill ill JJ cord-011418-hy8xmtiq 200 10 youth youth NN cord-011418-hy8xmtiq 200 11 and and CC cord-011418-hy8xmtiq 200 12 children child NNS cord-011418-hy8xmtiq 200 13 , , , cord-011418-hy8xmtiq 200 14 a a DT cord-011418-hy8xmtiq 200 15 preliminary preliminary JJ cord-011418-hy8xmtiq 200 16 evaluation evaluation NN cord-011418-hy8xmtiq 200 17 : : : cord-011418-hy8xmtiq 200 18 the the DT cord-011418-hy8xmtiq 200 19 wEECYCLE wEECYCLE NNP cord-011418-hy8xmtiq 200 20 pilot pilot NN cord-011418-hy8xmtiq 200 21 trial trial NN cord-011418-hy8xmtiq 200 22 Early early JJ cord-011418-hy8xmtiq 200 23 protocolized protocolize VBD cord-011418-hy8xmtiq 200 24 versus versus IN cord-011418-hy8xmtiq 200 25 usual usual JJ cord-011418-hy8xmtiq 200 26 care care NN cord-011418-hy8xmtiq 200 27 rehabilitation rehabilitation NN cord-011418-hy8xmtiq 200 28 for for IN cord-011418-hy8xmtiq 200 29 pediatric pediatric JJ cord-011418-hy8xmtiq 200 30 neurocritical neurocritical NNP cord-011418-hy8xmtiq 200 31 care care NN cord-011418-hy8xmtiq 200 32 patients patient NNS cord-011418-hy8xmtiq 200 33 : : : cord-011418-hy8xmtiq 200 34 a a DT cord-011418-hy8xmtiq 200 35 randomized randomized JJ cord-011418-hy8xmtiq 200 36 controlled control VBN cord-011418-hy8xmtiq 200 37 trial trial NN cord-011418-hy8xmtiq 200 38 Mobilization mobilization NN cord-011418-hy8xmtiq 200 39 therapy therapy NN cord-011418-hy8xmtiq 200 40 in in IN cord-011418-hy8xmtiq 200 41 the the DT cord-011418-hy8xmtiq 200 42 pediatric pediatric JJ cord-011418-hy8xmtiq 200 43 intensive intensive JJ cord-011418-hy8xmtiq 200 44 care care NN cord-011418-hy8xmtiq 200 45 unit unit NN cord-011418-hy8xmtiq 200 46 : : : cord-011418-hy8xmtiq 200 47 a a DT cord-011418-hy8xmtiq 200 48 multidisciplinary multidisciplinary JJ cord-011418-hy8xmtiq 200 49 quality quality NN cord-011418-hy8xmtiq 200 50 improvement improvement NN cord-011418-hy8xmtiq 200 51 initiative initiative NN cord-011418-hy8xmtiq 200 52 Implementation implementation NN cord-011418-hy8xmtiq 200 53 of of IN cord-011418-hy8xmtiq 200 54 an an DT cord-011418-hy8xmtiq 200 55 ICU ICU NNP cord-011418-hy8xmtiq 200 56 Bundle bundle NN cord-011418-hy8xmtiq 200 57 : : : cord-011418-hy8xmtiq 200 58 an an DT cord-011418-hy8xmtiq 200 59 interprofessional interprofessional JJ cord-011418-hy8xmtiq 200 60 quality quality NN cord-011418-hy8xmtiq 200 61 improvement improvement NN cord-011418-hy8xmtiq 200 62 project project NN cord-011418-hy8xmtiq 200 63 to to TO cord-011418-hy8xmtiq 200 64 enhance enhance VB cord-011418-hy8xmtiq 200 65 delirium delirium NN cord-011418-hy8xmtiq 200 66 management management NN cord-011418-hy8xmtiq 200 67 and and CC cord-011418-hy8xmtiq 200 68 monitor monitor VB cord-011418-hy8xmtiq 200 69 delirium delirium NN cord-011418-hy8xmtiq 200 70 prevalence prevalence NN cord-011418-hy8xmtiq 200 71 in in IN cord-011418-hy8xmtiq 200 72 a a DT cord-011418-hy8xmtiq 200 73 single single JJ cord-011418-hy8xmtiq 200 74 PICU PICU NNP cord-011418-hy8xmtiq 200 75 Pediatric Pediatric NNP cord-011418-hy8xmtiq 200 76 cohort cohort NN cord-011418-hy8xmtiq 200 77 study study NN cord-011418-hy8xmtiq 200 78 showing show VBG cord-011418-hy8xmtiq 200 79 physical physical JJ cord-011418-hy8xmtiq 200 80 improvement improvement NN cord-011418-hy8xmtiq 200 81 in in IN cord-011418-hy8xmtiq 200 82 pediatric pediatric JJ cord-011418-hy8xmtiq 200 83 liver liver NN cord-011418-hy8xmtiq 200 84 Family Family NNP cord-011418-hy8xmtiq 200 85 presence presence NN cord-011418-hy8xmtiq 200 86 : : : cord-011418-hy8xmtiq 200 87 Visitation visitation NN cord-011418-hy8xmtiq 200 88 in in IN cord-011418-hy8xmtiq 200 89 the the DT cord-011418-hy8xmtiq 200 90 adult adult NN cord-011418-hy8xmtiq 200 91 ICU ICU NNP cord-011418-hy8xmtiq 200 92 . . . cord-011418-hy8xmtiq 201 1 Crit Crit NNP cord-011418-hy8xmtiq 201 2 Care Care NNP cord-011418-hy8xmtiq 201 3 Nurse Nurse NNP cord-011418-hy8xmtiq 201 4 Family Family NNP cord-011418-hy8xmtiq 201 5 - - HYPH cord-011418-hy8xmtiq 201 6 centered center VBN cord-011418-hy8xmtiq 201 7 care care NN cord-011418-hy8xmtiq 201 8 in in IN cord-011418-hy8xmtiq 201 9 the the DT cord-011418-hy8xmtiq 201 10 pediatric pediatric JJ cord-011418-hy8xmtiq 201 11 intensive intensive JJ cord-011418-hy8xmtiq 201 12 care care NN cord-011418-hy8xmtiq 201 13 unit unit NN cord-011418-hy8xmtiq 201 14 . . . cord-011418-hy8xmtiq 202 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 202 2 Clin Clin NNP cord-011418-hy8xmtiq 202 3 N N NNP cord-011418-hy8xmtiq 202 4 Am Am NNP cord-011418-hy8xmtiq 202 5 Patient patient NN cord-011418-hy8xmtiq 202 6 - - : cord-011418-hy8xmtiq 202 7 and and CC cord-011418-hy8xmtiq 202 8 family family NN cord-011418-hy8xmtiq 202 9 - - HYPH cord-011418-hy8xmtiq 202 10 centered center VBN cord-011418-hy8xmtiq 202 11 care care NN cord-011418-hy8xmtiq 202 12 : : : cord-011418-hy8xmtiq 202 13 leveraging leverage VBG cord-011418-hy8xmtiq 202 14 best good JJS cord-011418-hy8xmtiq 202 15 practices practice NNS cord-011418-hy8xmtiq 202 16 to to TO cord-011418-hy8xmtiq 202 17 improve improve VB cord-011418-hy8xmtiq 202 18 the the DT cord-011418-hy8xmtiq 202 19 care care NN cord-011418-hy8xmtiq 202 20 of of IN cord-011418-hy8xmtiq 202 21 hospitalized hospitalize VBN cord-011418-hy8xmtiq 202 22 children child NNS cord-011418-hy8xmtiq 202 23 . . . cord-011418-hy8xmtiq 203 1 Pediatr Pediatr NNP cord-011418-hy8xmtiq 203 2 Clin Clin NNP cord-011418-hy8xmtiq 203 3 N N NNP cord-011418-hy8xmtiq 203 4 Am Am NNP cord-011418-hy8xmtiq 203 5 Identifying identify VBG cord-011418-hy8xmtiq 203 6 barriers barrier NNS cord-011418-hy8xmtiq 203 7 to to IN cord-011418-hy8xmtiq 203 8 delivering deliver VBG cord-011418-hy8xmtiq 203 9 the the DT cord-011418-hy8xmtiq 203 10 awakening awakening NN cord-011418-hy8xmtiq 203 11 and and CC cord-011418-hy8xmtiq 203 12 breathing breathing NN cord-011418-hy8xmtiq 203 13 coordination coordination NN cord-011418-hy8xmtiq 203 14 , , , cord-011418-hy8xmtiq 203 15 delirium delirium NN cord-011418-hy8xmtiq 203 16 , , , cord-011418-hy8xmtiq 203 17 and and CC cord-011418-hy8xmtiq 203 18 early early JJ cord-011418-hy8xmtiq 203 19 exercise exercise NN cord-011418-hy8xmtiq 203 20 / / SYM cord-011418-hy8xmtiq 203 21 mobility mobility NN cord-011418-hy8xmtiq 203 22 bundle bundle NN cord-011418-hy8xmtiq 203 23 to to TO cord-011418-hy8xmtiq 203 24 minimize minimize VB cord-011418-hy8xmtiq 203 25 adverse adverse JJ cord-011418-hy8xmtiq 203 26 outcomes outcome NNS cord-011418-hy8xmtiq 203 27 for for IN cord-011418-hy8xmtiq 203 28 mechanically mechanically RB cord-011418-hy8xmtiq 203 29 ventilated ventilate VBN cord-011418-hy8xmtiq 203 30 patients patient NNS cord-011418-hy8xmtiq 203 31 : : : cord-011418-hy8xmtiq 203 32 a a DT cord-011418-hy8xmtiq 203 33 systematic systematic JJ cord-011418-hy8xmtiq 203 34 review review NN cord-011418-hy8xmtiq 203 35 Fostering foster VBG cord-011418-hy8xmtiq 203 36 implementation implementation NN cord-011418-hy8xmtiq 203 37 of of IN cord-011418-hy8xmtiq 203 38 health health NN cord-011418-hy8xmtiq 203 39 services service NNS cord-011418-hy8xmtiq 203 40 research research NN cord-011418-hy8xmtiq 203 41 findings finding NNS cord-011418-hy8xmtiq 203 42 into into IN cord-011418-hy8xmtiq 203 43 practice practice NN cord-011418-hy8xmtiq 203 44 : : : cord-011418-hy8xmtiq 203 45 a a DT cord-011418-hy8xmtiq 203 46 consolidated consolidated JJ cord-011418-hy8xmtiq 203 47 framework framework NN cord-011418-hy8xmtiq 203 48 for for IN cord-011418-hy8xmtiq 203 49 advancing advance VBG cord-011418-hy8xmtiq 203 50 implementation implementation NN cord-011418-hy8xmtiq 203 51 science science NN cord-011418-hy8xmtiq 203 52 Common common JJ cord-011418-hy8xmtiq 203 53 challenges challenge NNS cord-011418-hy8xmtiq 203 54 to to TO cord-011418-hy8xmtiq 203 55 effective effective JJ cord-011418-hy8xmtiq 203 56 ABCDEF ABCDEF NNP cord-011418-hy8xmtiq 203 57 bundle bundle NN cord-011418-hy8xmtiq 203 58 implementation implementation NN cord-011418-hy8xmtiq 203 59 : : : cord-011418-hy8xmtiq 203 60 the the DT cord-011418-hy8xmtiq 203 61 ICU ICU NNP cord-011418-hy8xmtiq 203 62 liberation liberation NN cord-011418-hy8xmtiq 203 63 campaign campaign NN cord-011418-hy8xmtiq 203 64 experience experience NN cord-011418-hy8xmtiq 203 65 . . . cord-011418-hy8xmtiq 204 1 Crit Crit NNP cord-011418-hy8xmtiq 204 2 Care Care NNP cord-011418-hy8xmtiq 204 3 Nurse Nurse NNP cord-011418-hy8xmtiq 204 4 Publisher Publisher NNP cord-011418-hy8xmtiq 204 5 's 's POS cord-011418-hy8xmtiq 204 6 Note Note NNP cord-011418-hy8xmtiq 204 7 Springer Springer NNP cord-011418-hy8xmtiq 204 8 Nature Nature NNP cord-011418-hy8xmtiq 204 9 remains remain VBZ cord-011418-hy8xmtiq 204 10 neutral neutral JJ cord-011418-hy8xmtiq 204 11 with with IN cord-011418-hy8xmtiq 204 12 regard regard NN cord-011418-hy8xmtiq 204 13 to to IN cord-011418-hy8xmtiq 204 14 jurisdictional jurisdictional JJ cord-011418-hy8xmtiq 204 15 claims claim NNS cord-011418-hy8xmtiq 204 16 in in IN cord-011418-hy8xmtiq 204 17 published publish VBN cord-011418-hy8xmtiq 204 18 maps map NNS cord-011418-hy8xmtiq 204 19 and and CC cord-011418-hy8xmtiq 204 20 institutional institutional JJ cord-011418-hy8xmtiq 204 21 affiliations affiliation NNS