id	sid	tid	token	lemma	pos
cord-018182-lleti89n	1	1	key	key	JJ
cord-018182-lleti89n	2	1	:	:	:
cord-018182-lleti89n	2	2	cord-018182-lleti89n	cord-018182-lleti89n	RB
cord-018182-lleti89n	2	3	authors	author	NNS
cord-018182-lleti89n	2	4	:	:	:
cord-018182-lleti89n	2	5	Kassutto	Kassutto	NNP
cord-018182-lleti89n	2	6	,	,	,
cord-018182-lleti89n	2	7	Stacey	Stacey	NNP
cord-018182-lleti89n	2	8	M.	M.	NNP
cord-018182-lleti89n	2	9	;	;	:
cord-018182-lleti89n	2	10	Kayser	Kayser	NNP
cord-018182-lleti89n	2	11	,	,	,
cord-018182-lleti89n	2	12	Joshua	Joshua	NNP
cord-018182-lleti89n	2	13	B.	B.	NNP
cord-018182-lleti89n	2	14	title	title	NN
cord-018182-lleti89n	2	15	:	:	:
cord-018182-lleti89n	2	16	Care	care	NN
cord-018182-lleti89n	2	17	of	of	IN
cord-018182-lleti89n	2	18	the	the	DT
cord-018182-lleti89n	2	19	Surgical	surgical	JJ
cord-018182-lleti89n	2	20	ICU	ICU	NNP
cord-018182-lleti89n	2	21	Patient	Patient	NNP
cord-018182-lleti89n	2	22	with	with	IN
cord-018182-lleti89n	2	23	Chronic	Chronic	NNP
cord-018182-lleti89n	2	24	Obstructive	obstructive	JJ
cord-018182-lleti89n	2	25	Pulmonary	Pulmonary	NNP
cord-018182-lleti89n	2	26	Disease	Disease	NNP
cord-018182-lleti89n	2	27	and	and	CC
cord-018182-lleti89n	2	28	Pulmonary	Pulmonary	NNP
cord-018182-lleti89n	2	29	Hypertension	Hypertension	NNP
cord-018182-lleti89n	2	30	date	date	NN
cord-018182-lleti89n	2	31	:	:	:
cord-018182-lleti89n	2	32	2016	2016	CD
cord-018182-lleti89n	2	33	-	-	SYM
cord-018182-lleti89n	2	34	10	10	CD
cord-018182-lleti89n	2	35	-	-	HYPH
cord-018182-lleti89n	2	36	09	09	CD
cord-018182-lleti89n	2	37	journal	journal	NN
cord-018182-lleti89n	2	38	:	:	:
cord-018182-lleti89n	2	39	Principles	principle	NNS
cord-018182-lleti89n	2	40	of	of	IN
cord-018182-lleti89n	2	41	Adult	Adult	NNP
cord-018182-lleti89n	2	42	Surgical	Surgical	NNP
cord-018182-lleti89n	2	43	Critical	critical	JJ
cord-018182-lleti89n	2	44	Care	care	NN
cord-018182-lleti89n	2	45	DOI	doi	NN
cord-018182-lleti89n	2	46	:	:	:
cord-018182-lleti89n	2	47	10.1007/978	10.1007/978	CD
cord-018182-lleti89n	2	48	-	-	HYPH
cord-018182-lleti89n	2	49	3	3	CD
cord-018182-lleti89n	2	50	-	-	HYPH
cord-018182-lleti89n	2	51	319	319	CD
cord-018182-lleti89n	2	52	-	-	HYPH
cord-018182-lleti89n	2	53	33341	33341	CD
cord-018182-lleti89n	2	54	-	-	HYPH
cord-018182-lleti89n	2	55	0_13	0_13	CD
cord-018182-lleti89n	2	56	sha	sha	NNP
cord-018182-lleti89n	2	57	:	:	:
cord-018182-lleti89n	3	1	97433e220f22ce9cb6f3a5ea8b3df20b6f851692	97433e220f22ce9cb6f3a5ea8b3df20b6f851692	CD
cord-018182-lleti89n	3	2	doc_id	doc_id	CD
cord-018182-lleti89n	3	3	:	:	:
cord-018182-lleti89n	4	1	18182	18182	CD
cord-018182-lleti89n	5	1	cord_uid	cord_uid	NNS
cord-018182-lleti89n	5	2	:	:	:
cord-018182-lleti89n	5	3	lleti89n	lleti89n	JJ
cord-018182-lleti89n	5	4	Chronic	chronic	JJ
cord-018182-lleti89n	5	5	obstructive	obstructive	JJ
cord-018182-lleti89n	5	6	pulmonary	pulmonary	JJ
cord-018182-lleti89n	5	7	disease	disease	NN
cord-018182-lleti89n	5	8	(	(	-LRB-
cord-018182-lleti89n	5	9	COPD	COPD	NNP
cord-018182-lleti89n	5	10	)	)	-RRB-
cord-018182-lleti89n	5	11	is	be	VBZ
cord-018182-lleti89n	5	12	a	a	DT
cord-018182-lleti89n	5	13	progressive	progressive	JJ
cord-018182-lleti89n	5	14	chronic	chronic	JJ
cord-018182-lleti89n	5	15	disease	disease	NN
cord-018182-lleti89n	5	16	characterized	characterize	VBN
cord-018182-lleti89n	5	17	by	by	IN
cord-018182-lleti89n	5	18	airflow	airflow	NN
cord-018182-lleti89n	5	19	limitation	limitation	NN
cord-018182-lleti89n	5	20	that	that	WDT
cord-018182-lleti89n	5	21	is	be	VBZ
cord-018182-lleti89n	5	22	frequently	frequently	RB
cord-018182-lleti89n	5	23	progressive	progressive	JJ
cord-018182-lleti89n	5	24	and	and	CC
cord-018182-lleti89n	5	25	associated	associate	VBN
cord-018182-lleti89n	5	26	with	with	IN
cord-018182-lleti89n	5	27	respiratory	respiratory	JJ
cord-018182-lleti89n	5	28	impairment	impairment	NN
cord-018182-lleti89n	5	29	.	.	.
cord-018182-lleti89n	6	1	As	as	IN
cord-018182-lleti89n	6	2	the	the	DT
cord-018182-lleti89n	6	3	fourth	fourth	JJ
cord-018182-lleti89n	6	4	leading	leading	NN
cord-018182-lleti89n	6	5	cause	cause	NN
cord-018182-lleti89n	6	6	of	of	IN
cord-018182-lleti89n	6	7	death	death	NN
cord-018182-lleti89n	6	8	in	in	IN
cord-018182-lleti89n	6	9	the	the	DT
cord-018182-lleti89n	6	10	United	United	NNP
cord-018182-lleti89n	6	11	States	States	NNP
cord-018182-lleti89n	6	12	and	and	CC
cord-018182-lleti89n	6	13	Europe	Europe	NNP
cord-018182-lleti89n	6	14	,	,	,
cord-018182-lleti89n	6	15	COPD	COPD	NNP
cord-018182-lleti89n	6	16	results	result	NNS
cord-018182-lleti89n	6	17	in	in	IN
cord-018182-lleti89n	6	18	a	a	DT
cord-018182-lleti89n	6	19	substantial	substantial	JJ
cord-018182-lleti89n	6	20	and	and	CC
cord-018182-lleti89n	6	21	ever	ever	RB
cord-018182-lleti89n	6	22	increasing	increase	VBG
cord-018182-lleti89n	6	23	economic	economic	JJ
cord-018182-lleti89n	6	24	and	and	CC
cord-018182-lleti89n	6	25	social	social	JJ
cord-018182-lleti89n	6	26	burden	burden	NN
cord-018182-lleti89n	6	27	[	[	-LRB-
cord-018182-lleti89n	6	28	1	1	CD
cord-018182-lleti89n	6	29	]	]	-RRB-
cord-018182-lleti89n	6	30	.	.	.
cord-018182-lleti89n	7	1	Acute	acute	JJ
cord-018182-lleti89n	7	2	exacerbations	exacerbation	NNS
cord-018182-lleti89n	7	3	of	of	IN
cord-018182-lleti89n	7	4	chronic	chronic	JJ
cord-018182-lleti89n	7	5	obstructive	obstructive	JJ
cord-018182-lleti89n	7	6	pulmonary	pulmonary	JJ
cord-018182-lleti89n	7	7	disease	disease	NN
cord-018182-lleti89n	7	8	(	(	-LRB-
cord-018182-lleti89n	7	9	AECOPD	AECOPD	NNP
cord-018182-lleti89n	7	10	)	)	-RRB-
cord-018182-lleti89n	7	11	are	be	VBP
cord-018182-lleti89n	7	12	frequently	frequently	RB
cord-018182-lleti89n	7	13	encountered	encounter	VBN
cord-018182-lleti89n	7	14	in	in	IN
cord-018182-lleti89n	7	15	the	the	DT
cord-018182-lleti89n	7	16	intensive	intensive	JJ
cord-018182-lleti89n	7	17	care	care	NN
cord-018182-lleti89n	7	18	unit	unit	NN
cord-018182-lleti89n	7	19	(	(	-LRB-
cord-018182-lleti89n	7	20	ICU	ICU	NNP
cord-018182-lleti89n	7	21	)	)	-RRB-
cord-018182-lleti89n	7	22	.	.	.
cord-018182-lleti89n	8	1	Although	although	IN
cord-018182-lleti89n	8	2	there	there	EX
cord-018182-lleti89n	8	3	is	be	VBZ
cord-018182-lleti89n	8	4	no	no	DT
cord-018182-lleti89n	8	5	standardized	standardized	JJ
cord-018182-lleti89n	8	6	definition	definition	NN
cord-018182-lleti89n	8	7	,	,	,
cord-018182-lleti89n	8	8	AECOPD	AECOPD	NNP
cord-018182-lleti89n	8	9	are	be	VBP
cord-018182-lleti89n	8	10	characterized	characterize	VBN
cord-018182-lleti89n	8	11	by	by	IN
cord-018182-lleti89n	8	12	a	a	DT
cord-018182-lleti89n	8	13	significant	significant	JJ
cord-018182-lleti89n	8	14	change	change	NN
cord-018182-lleti89n	8	15	in	in	IN
cord-018182-lleti89n	8	16	patient	patient	JJ
cord-018182-lleti89n	8	17	symptoms	symptom	NNS
cord-018182-lleti89n	8	18	from	from	IN
cord-018182-lleti89n	8	19	baseline	baseline	JJ
cord-018182-lleti89n	8	20	accompanied	accompany	VBN
cord-018182-lleti89n	8	21	by	by	IN
cord-018182-lleti89n	8	22	overall	overall	JJ
cord-018182-lleti89n	8	23	increased	increase	VBN
cord-018182-lleti89n	8	24	airway	airway	NN
cord-018182-lleti89n	8	25	resistance	resistance	NN
cord-018182-lleti89n	8	26	[	[	-LRB-
cord-018182-lleti89n	8	27	2	2	CD
cord-018182-lleti89n	8	28	]	]	-RRB-
cord-018182-lleti89n	8	29	.	.	.
cord-018182-lleti89n	9	1	These	these	DT
cord-018182-lleti89n	9	2	exacerbations	exacerbation	NNS
cord-018182-lleti89n	9	3	carry	carry	VBP
cord-018182-lleti89n	9	4	a	a	DT
cord-018182-lleti89n	9	5	significant	significant	JJ
cord-018182-lleti89n	9	6	risk	risk	NN
cord-018182-lleti89n	9	7	to	to	IN
cord-018182-lleti89n	9	8	patients	patient	NNS
cord-018182-lleti89n	9	9	,	,	,
cord-018182-lleti89n	9	10	with	with	IN
cord-018182-lleti89n	9	11	10	10	CD
cord-018182-lleti89n	9	12	%	%	NN
cord-018182-lleti89n	9	13	in	in	IN
cord-018182-lleti89n	9	14	-	-	HYPH
cord-018182-lleti89n	9	15	hospital	hospital	NN
cord-018182-lleti89n	9	16	mortality	mortality	NN
cord-018182-lleti89n	9	17	and	and	CC
cord-018182-lleti89n	9	18	1-year	1-year	CD
cord-018182-lleti89n	9	19	and	and	CC
cord-018182-lleti89n	9	20	2-year	2-year	CD
cord-018182-lleti89n	9	21	all	all	DT
cord-018182-lleti89n	9	22	-	-	HYPH
cord-018182-lleti89n	9	23	cause	cause	NN
cord-018182-lleti89n	9	24	mortality	mortality	NN
cord-018182-lleti89n	9	25	rates	rate	NNS
cord-018182-lleti89n	9	26	of	of	IN
cord-018182-lleti89n	9	27	43	43	CD
cord-018182-lleti89n	9	28	%	%	NN
cord-018182-lleti89n	9	29	and	and	CC
cord-018182-lleti89n	9	30	49	49	CD
cord-018182-lleti89n	9	31	%	%	NN
cord-018182-lleti89n	9	32	,	,	,
cord-018182-lleti89n	9	33	respectively	respectively	RB
cord-018182-lleti89n	9	34	,	,	,
cord-018182-lleti89n	9	35	in	in	IN
cord-018182-lleti89n	9	36	patients	patient	NNS
cord-018182-lleti89n	9	37	with	with	IN
cord-018182-lleti89n	9	38	hypercapnic	hypercapnic	NNP
cord-018182-lleti89n	9	39	exacerbations	exacerbation	NNS
cord-018182-lleti89n	9	40	[	[	-LRB-
cord-018182-lleti89n	9	41	3	3	CD
cord-018182-lleti89n	9	42	]	]	-RRB-
cord-018182-lleti89n	9	43	.	.	.
cord-018182-lleti89n	10	1	Other	other	JJ
cord-018182-lleti89n	10	2	studies	study	NNS
cord-018182-lleti89n	10	3	note	note	VBP
cord-018182-lleti89n	10	4	in	in	IN
cord-018182-lleti89n	10	5	-	-	HYPH
cord-018182-lleti89n	10	6	hospital	hospital	NN
cord-018182-lleti89n	10	7	mortality	mortality	NN
cord-018182-lleti89n	10	8	rates	rate	NNS
cord-018182-lleti89n	10	9	as	as	RB
cord-018182-lleti89n	10	10	high	high	JJ
cord-018182-lleti89n	10	11	as	as	IN
cord-018182-lleti89n	10	12	30	30	CD
cord-018182-lleti89n	10	13	%	%	NN
cord-018182-lleti89n	10	14	with	with	IN
cord-018182-lleti89n	10	15	worse	bad	JJR
cord-018182-lleti89n	10	16	outcomes	outcome	NNS
cord-018182-lleti89n	10	17	associated	associate	VBN
cord-018182-lleti89n	10	18	with	with	IN
cord-018182-lleti89n	10	19	older	old	JJR
cord-018182-lleti89n	10	20	age	age	NN
cord-018182-lleti89n	10	21	,	,	,
cord-018182-lleti89n	10	22	severity	severity	NN
cord-018182-lleti89n	10	23	of	of	IN
cord-018182-lleti89n	10	24	respiratory	respiratory	JJ
cord-018182-lleti89n	10	25	and	and	CC
cord-018182-lleti89n	10	26	non	non	JJ
cord-018182-lleti89n	10	27	-	-	JJ
cord-018182-lleti89n	10	28	respiratory	respiratory	JJ
cord-018182-lleti89n	10	29	organ	organ	NN
cord-018182-lleti89n	10	30	dysfunction	dysfunction	NN
cord-018182-lleti89n	10	31	,	,	,
cord-018182-lleti89n	10	32	and	and	CC
cord-018182-lleti89n	10	33	hospital	hospital	NN
cord-018182-lleti89n	10	34	length	length	NN
cord-018182-lleti89n	10	35	of	of	IN
cord-018182-lleti89n	10	36	stay	stay	NN
cord-018182-lleti89n	10	37	[	[	-LRB-
cord-018182-lleti89n	10	38	4	4	CD
cord-018182-lleti89n	10	39	]	]	-RRB-
cord-018182-lleti89n	10	40	.	.	.
cord-018182-lleti89n	11	1	Given	give	VBN
cord-018182-lleti89n	11	2	that	that	IN
cord-018182-lleti89n	11	3	patients	patient	NNS
cord-018182-lleti89n	11	4	transferred	transfer	VBN
cord-018182-lleti89n	11	5	to	to	IN
cord-018182-lleti89n	11	6	the	the	DT
cord-018182-lleti89n	11	7	ICU	ICU	NNP
cord-018182-lleti89n	11	8	with	with	IN
cord-018182-lleti89n	11	9	AECOPD	AECOPD	NNP
cord-018182-lleti89n	11	10	are	be	VBP
cord-018182-lleti89n	11	11	at	at	IN
cord-018182-lleti89n	11	12	high	high	JJ
cord-018182-lleti89n	11	13	risk	risk	NN
cord-018182-lleti89n	11	14	for	for	IN
cord-018182-lleti89n	11	15	complications	complication	NNS
cord-018182-lleti89n	11	16	and	and	CC
cord-018182-lleti89n	11	17	adverse	adverse	JJ
cord-018182-lleti89n	11	18	outcomes	outcome	NNS
cord-018182-lleti89n	11	19	,	,	,
cord-018182-lleti89n	11	20	early	early	JJ
cord-018182-lleti89n	11	21	diagnosis	diagnosis	NN
cord-018182-lleti89n	11	22	and	and	CC
cord-018182-lleti89n	11	23	management	management	NN
cord-018182-lleti89n	11	24	are	be	VBP
cord-018182-lleti89n	11	25	critical	critical	JJ
cord-018182-lleti89n	11	26	to	to	TO
cord-018182-lleti89n	11	27	improve	improve	VB
cord-018182-lleti89n	11	28	patient	patient	JJ
cord-018182-lleti89n	11	29	outcomes	outcome	NNS
cord-018182-lleti89n	11	30	and	and	CC
cord-018182-lleti89n	11	31	survival	survival	NN
cord-018182-lleti89n	11	32	in	in	IN
cord-018182-lleti89n	11	33	this	this	DT
cord-018182-lleti89n	11	34	population	population	NN
cord-018182-lleti89n	11	35	.	.	.
cord-018182-lleti89n	12	1	AECOPD	AECOPD	NNP
cord-018182-lleti89n	12	2	are	be	VBP
cord-018182-lleti89n	12	3	the	the	DT
cord-018182-lleti89n	12	4	result	result	NN
cord-018182-lleti89n	12	5	of	of	IN
cord-018182-lleti89n	12	6	increased	increase	VBN
cord-018182-lleti89n	12	7	airway	airway	NN
cord-018182-lleti89n	12	8	resistance	resistance	NN
cord-018182-lleti89n	12	9	as	as	IN
cord-018182-lleti89n	12	10	a	a	DT
cord-018182-lleti89n	12	11	consequence	consequence	NN
cord-018182-lleti89n	12	12	of	of	IN
cord-018182-lleti89n	12	13	inflammation	inflammation	NN
cord-018182-lleti89n	12	14	and/or	and/or	CC
cord-018182-lleti89n	12	15	increased	increase	VBN
cord-018182-lleti89n	12	16	airway	airway	NN
cord-018182-lleti89n	12	17	secretions	secretion	NNS
cord-018182-lleti89n	12	18	.	.	.
cord-018182-lleti89n	13	1	Data	Data	NNP
cord-018182-lleti89n	13	2	suggests	suggest	VBZ
cord-018182-lleti89n	13	3	that	that	IN
cord-018182-lleti89n	13	4	50	50	CD
cord-018182-lleti89n	13	5	-	-	SYM
cord-018182-lleti89n	13	6	70	70	CD
cord-018182-lleti89n	13	7	%	%	NN
cord-018182-lleti89n	13	8	of	of	IN
cord-018182-lleti89n	13	9	AECOPD	AECOPD	NNP
cord-018182-lleti89n	13	10	are	be	VBP
cord-018182-lleti89n	13	11	due	due	JJ
cord-018182-lleti89n	13	12	to	to	IN
cord-018182-lleti89n	13	13	respiratory	respiratory	JJ
cord-018182-lleti89n	13	14	infections	infection	NNS
cord-018182-lleti89n	13	15	,	,	,
cord-018182-lleti89n	13	16	with	with	IN
cord-018182-lleti89n	13	17	greater	great	JJR
cord-018182-lleti89n	13	18	than	than	IN
cord-018182-lleti89n	13	19	50	50	CD
cord-018182-lleti89n	13	20	%	%	NN
cord-018182-lleti89n	13	21	being	be	VBG
cord-018182-lleti89n	13	22	due	due	JJ
cord-018182-lleti89n	13	23	to	to	IN
cord-018182-lleti89n	13	24	bacterial	bacterial	JJ
cord-018182-lleti89n	13	25	pathogens	pathogen	NNS
cord-018182-lleti89n	13	26	.	.	.
cord-018182-lleti89n	14	1	The	the	DT
cord-018182-lleti89n	14	2	most	most	RBS
cord-018182-lleti89n	14	3	commonly	commonly	RB
cord-018182-lleti89n	14	4	isolated	isolate	VBN
cord-018182-lleti89n	14	5	organisms	organism	NNS
cord-018182-lleti89n	14	6	include	include	VBP
cord-018182-lleti89n	14	7	Haemophilus	Haemophilus	NNP
cord-018182-lleti89n	14	8	influenza	influenza	NN
cord-018182-lleti89n	14	9	,	,	,
cord-018182-lleti89n	14	10	Streptococcus	Streptococcus	NNP
cord-018182-lleti89n	14	11	pneumonia	pneumonia	NN
cord-018182-lleti89n	14	12	,	,	,
cord-018182-lleti89n	14	13	Moraxella	Moraxella	NNP
cord-018182-lleti89n	14	14	catarrhalis	catarrhalis	NNP
cord-018182-lleti89n	14	15	,	,	,
cord-018182-lleti89n	14	16	and	and	CC
cord-018182-lleti89n	14	17	Pseudomonas	Pseudomonas	NNP
cord-018182-lleti89n	14	18	aeruginosa	aeruginosa	NN
cord-018182-lleti89n	14	19	.	.	.
cord-018182-lleti89n	15	1	Gram	gram	NN
cord-018182-lleti89n	15	2	-	-	HYPH
cord-018182-lleti89n	15	3	negative	negative	JJ
cord-018182-lleti89n	15	4	rods	rod	NNS
cord-018182-lleti89n	15	5	are	be	VBP
cord-018182-lleti89n	15	6	isolated	isolate	VBN
cord-018182-lleti89n	15	7	less	less	RBR
cord-018182-lleti89n	15	8	frequently	frequently	RB
cord-018182-lleti89n	15	9	but	but	CC
cord-018182-lleti89n	15	10	are	be	VBP
cord-018182-lleti89n	15	11	more	more	RBR
cord-018182-lleti89n	15	12	common	common	JJ
cord-018182-lleti89n	15	13	in	in	IN
cord-018182-lleti89n	15	14	patients	patient	NNS
cord-018182-lleti89n	15	15	with	with	IN
cord-018182-lleti89n	15	16	advanced	advanced	JJ
cord-018182-lleti89n	15	17	disease	disease	NN
cord-018182-lleti89n	15	18	and	and	CC
cord-018182-lleti89n	15	19	more	more	RBR
cord-018182-lleti89n	15	20	severe	severe	JJ
cord-018182-lleti89n	15	21	exacerbations	exacerbation	NNS
cord-018182-lleti89n	15	22	as	as	RB
cord-018182-lleti89n	15	23	well	well	RB
cord-018182-lleti89n	15	24	as	as	IN
cord-018182-lleti89n	15	25	those	those	DT
cord-018182-lleti89n	15	26	with	with	IN
cord-018182-lleti89n	15	27	diabetes	diabete	NNS
cord-018182-lleti89n	15	28	.	.	.
cord-018182-lleti89n	16	1	Patients	patient	NNS
cord-018182-lleti89n	16	2	may	may	MD
cord-018182-lleti89n	16	3	be	be	VB
cord-018182-lleti89n	16	4	chronically	chronically	RB
cord-018182-lleti89n	16	5	colonized	colonize	VBN
cord-018182-lleti89n	16	6	with	with	IN
cord-018182-lleti89n	16	7	bacteria	bacteria	NNS
cord-018182-lleti89n	16	8	in	in	IN
cord-018182-lleti89n	16	9	the	the	DT
cord-018182-lleti89n	16	10	respiratory	respiratory	JJ
cord-018182-lleti89n	16	11	tract	tract	NN
cord-018182-lleti89n	16	12	,	,	,
cord-018182-lleti89n	16	13	but	but	CC
cord-018182-lleti89n	16	14	it	-PRON-	PRP
cord-018182-lleti89n	16	15	is	be	VBZ
cord-018182-lleti89n	16	16	unclear	unclear	JJ
cord-018182-lleti89n	16	17	whether	whether	IN
cord-018182-lleti89n	16	18	asymptomatic	asymptomatic	JJ
cord-018182-lleti89n	16	19	colonization	colonization	NN
cord-018182-lleti89n	16	20	leads	lead	VBZ
cord-018182-lleti89n	16	21	to	to	IN
cord-018182-lleti89n	16	22	exacerbations	exacerbation	NNS
cord-018182-lleti89n	16	23	caused	cause	VBN
cord-018182-lleti89n	16	24	by	by	IN
cord-018182-lleti89n	16	25	the	the	DT
cord-018182-lleti89n	16	26	same	same	JJ
cord-018182-lleti89n	16	27	bacterial	bacterial	JJ
cord-018182-lleti89n	16	28	strains	strain	NNS
cord-018182-lleti89n	16	29	or	or	CC
cord-018182-lleti89n	16	30	predisposes	predispose	VBZ
cord-018182-lleti89n	16	31	to	to	IN
cord-018182-lleti89n	16	32	new	new	JJ
cord-018182-lleti89n	16	33	bacterial	bacterial	JJ
cord-018182-lleti89n	16	34	growth	growth	NN
cord-018182-lleti89n	16	35	.	.	.
cord-018182-lleti89n	17	1	Atypical	atypical	JJ
cord-018182-lleti89n	17	2	bacteria	bacteria	NNS
cord-018182-lleti89n	17	3	such	such	JJ
cord-018182-lleti89n	17	4	as	as	IN
cord-018182-lleti89n	17	5	Mycoplasma	Mycoplasma	NNP
cord-018182-lleti89n	17	6	pneumonia	pneumonia	NN
cord-018182-lleti89n	17	7	may	may	MD
cord-018182-lleti89n	17	8	be	be	VB
cord-018182-lleti89n	17	9	responsible	responsible	JJ
cord-018182-lleti89n	17	10	for	for	IN
cord-018182-lleti89n	17	11	up	up	IN
cord-018182-lleti89n	17	12	to	to	TO
cord-018182-lleti89n	17	13	14	14	CD
cord-018182-lleti89n	17	14	%	%	NN
cord-018182-lleti89n	17	15	of	of	IN
cord-018182-lleti89n	17	16	exacerbations	exacerbation	NNS
cord-018182-lleti89n	17	17	[	[	-LRB-
cord-018182-lleti89n	17	18	2	2	CD
cord-018182-lleti89n	17	19	,	,	,
cord-018182-lleti89n	17	20	5	5	CD
cord-018182-lleti89n	17	21	]	]	-RRB-
cord-018182-lleti89n	17	22	.	.	.
cord-018182-lleti89n	18	1	Viral	viral	JJ
cord-018182-lleti89n	18	2	infections	infection	NNS
cord-018182-lleti89n	18	3	are	be	VBP
cord-018182-lleti89n	18	4	estimated	estimate	VBN
cord-018182-lleti89n	18	5	to	to	TO
cord-018182-lleti89n	18	6	cause	cause	VB
cord-018182-lleti89n	18	7	20	20	CD
cord-018182-lleti89n	18	8	-	-	SYM
cord-018182-lleti89n	18	9	40	40	CD
cord-018182-lleti89n	18	10	%	%	NN
cord-018182-lleti89n	18	11	of	of	IN
cord-018182-lleti89n	18	12	exacerbations	exacerbation	NNS
cord-018182-lleti89n	18	13	.	.	.
cord-018182-lleti89n	19	1	However	however	RB
cord-018182-lleti89n	19	2	,	,	,
cord-018182-lleti89n	19	3	many	many	JJ
cord-018182-lleti89n	19	4	patients	patient	NNS
cord-018182-lleti89n	19	5	with	with	IN
cord-018182-lleti89n	19	6	documented	document	VBN
cord-018182-lleti89n	19	7	bacterial	bacterial	JJ
cord-018182-lleti89n	19	8	infections	infection	NNS
cord-018182-lleti89n	19	9	report	report	VBP
cord-018182-lleti89n	19	10	a	a	DT
cord-018182-lleti89n	19	11	viral	viral	JJ
cord-018182-lleti89n	19	12	prodrome	prodrome	NN
cord-018182-lleti89n	19	13	,	,	,
cord-018182-lleti89n	19	14	making	make	VBG
cord-018182-lleti89n	19	15	the	the	DT
cord-018182-lleti89n	19	16	true	true	JJ
cord-018182-lleti89n	19	17	prevalence	prevalence	NN
cord-018182-lleti89n	19	18	of	of	IN
cord-018182-lleti89n	19	19	viral	viral	JJ
cord-018182-lleti89n	19	20	illness	illness	NN
cord-018182-lleti89n	19	21	difficult	difficult	JJ
cord-018182-lleti89n	19	22	to	to	TO
cord-018182-lleti89n	19	23	estimate	estimate	VB
cord-018182-lleti89n	19	24	.	.	.
cord-018182-lleti89n	20	1	Estimates	estimate	NNS
cord-018182-lleti89n	20	2	indicate	indicate	VBP
cord-018182-lleti89n	20	3	that	that	IN
cord-018182-lleti89n	20	4	rhinovirus	rhinovirus	NN
cord-018182-lleti89n	20	5	(	(	-LRB-
cord-018182-lleti89n	20	6	17	17	CD
cord-018182-lleti89n	20	7	-	-	SYM
cord-018182-lleti89n	20	8	25	25	CD
cord-018182-lleti89n	20	9	%	%	NN
cord-018182-lleti89n	20	10	)	)	-RRB-
cord-018182-lleti89n	20	11	,	,	,
cord-018182-lleti89n	20	12	influenza	influenza	NN
cord-018182-lleti89n	20	13	(	(	-LRB-
cord-018182-lleti89n	20	14	5	5	CD
cord-018182-lleti89n	20	15	-	-	SYM
cord-018182-lleti89n	20	16	28	28	CD
cord-018182-lleti89n	20	17	%	%	NN
cord-018182-lleti89n	20	18	)	)	-RRB-
cord-018182-lleti89n	20	19	,	,	,
cord-018182-lleti89n	20	20	parainfluenza	parainfluenza	NNP
cord-018182-lleti89n	20	21	(	(	-LRB-
cord-018182-lleti89n	20	22	5	5	CD
cord-018182-lleti89n	20	23	-	-	SYM
cord-018182-lleti89n	20	24	10	10	CD
cord-018182-lleti89n	20	25	%	%	NN
cord-018182-lleti89n	20	26	)	)	-RRB-
cord-018182-lleti89n	20	27	,	,	,
cord-018182-lleti89n	20	28	and	and	CC
cord-018182-lleti89n	20	29	respiratory	respiratory	JJ
cord-018182-lleti89n	20	30	syncytial	syncytial	JJ
cord-018182-lleti89n	20	31	virus	virus	NN
cord-018182-lleti89n	20	32	(	(	-LRB-
cord-018182-lleti89n	20	33	5	5	CD
cord-018182-lleti89n	20	34	-	-	SYM
cord-018182-lleti89n	20	35	10	10	CD
cord-018182-lleti89n	20	36	%	%	NN
cord-018182-lleti89n	20	37	)	)	-RRB-
cord-018182-lleti89n	20	38	are	be	VBP
cord-018182-lleti89n	20	39	among	among	IN
cord-018182-lleti89n	20	40	the	the	DT
cord-018182-lleti89n	20	41	most	most	RBS
cord-018182-lleti89n	20	42	common	common	JJ
cord-018182-lleti89n	20	43	viral	viral	JJ
cord-018182-lleti89n	20	44	pathogens	pathogen	NNS
cord-018182-lleti89n	20	45	in	in	IN
cord-018182-lleti89n	20	46	AECOPD	AECOPD	NNP
cord-018182-lleti89n	20	47	.	.	.
cord-018182-lleti89n	21	1	Adenovirus	Adenovirus	NNP
cord-018182-lleti89n	21	2	,	,	,
cord-018182-lleti89n	21	3	human	human	JJ
cord-018182-lleti89n	21	4	metapneumovirus	metapneumovirus	NN
cord-018182-lleti89n	21	5	,	,	,
cord-018182-lleti89n	21	6	and	and	CC
cord-018182-lleti89n	21	7	coronavirus	coronavirus	NN
cord-018182-lleti89n	21	8	are	be	VBP
cord-018182-lleti89n	21	9	also	also	RB
cord-018182-lleti89n	21	10	potential	potential	JJ
cord-018182-lleti89n	21	11	but	but	CC
cord-018182-lleti89n	21	12	less	less	RBR
cord-018182-lleti89n	21	13	common	common	JJ
cord-018182-lleti89n	21	14	culprits	culprit	NNS
cord-018182-lleti89n	21	15	.	.	.
cord-018182-lleti89n	22	1	In	in	IN
cord-018182-lleti89n	22	2	many	many	JJ
cord-018182-lleti89n	22	3	cases	case	NNS
cord-018182-lleti89n	22	4	the	the	DT
cord-018182-lleti89n	22	5	exact	exact	JJ
cord-018182-lleti89n	22	6	precipitant	precipitant	NN
cord-018182-lleti89n	22	7	of	of	IN
cord-018182-lleti89n	22	8	an	an	DT
cord-018182-lleti89n	22	9	exacerbation	exacerbation	NN
cord-018182-lleti89n	22	10	may	may	MD
cord-018182-lleti89n	22	11	never	never	RB
cord-018182-lleti89n	22	12	be	be	VB
cord-018182-lleti89n	22	13	identified	identify	VBN
cord-018182-lleti89n	22	14	[	[	-LRB-
cord-018182-lleti89n	22	15	2	2	CD
cord-018182-lleti89n	22	16	,	,	,
cord-018182-lleti89n	22	17	[	[	-LRB-
cord-018182-lleti89n	22	18	5	5	CD
cord-018182-lleti89n	22	19	]	]	-RRB-
cord-018182-lleti89n	22	20	[	[	-LRB-
cord-018182-lleti89n	22	21	6	6	CD
cord-018182-lleti89n	22	22	]	]	-RRB-
cord-018182-lleti89n	22	23	[	[	-LRB-
cord-018182-lleti89n	22	24	7	7	CD
cord-018182-lleti89n	22	25	]	]	-RRB-
cord-018182-lleti89n	22	26	.	.	.
cord-018182-lleti89n	23	1	prior	prior	JJ
cord-018182-lleti89n	23	2	need	need	NN
cord-018182-lleti89n	23	3	for	for	IN
cord-018182-lleti89n	23	4	mechanical	mechanical	JJ
cord-018182-lleti89n	23	5	ventilation	ventilation	NN
cord-018182-lleti89n	23	6	.	.	.
cord-018182-lleti89n	24	1	Patients	patient	NNS
cord-018182-lleti89n	24	2	with	with	IN
cord-018182-lleti89n	24	3	severe	severe	JJ
cord-018182-lleti89n	24	4	exacerbations	exacerbation	NNS
cord-018182-lleti89n	24	5	presenting	present	VBG
cord-018182-lleti89n	24	6	to	to	IN
cord-018182-lleti89n	24	7	the	the	DT
cord-018182-lleti89n	24	8	ICU	ICU	NNP
cord-018182-lleti89n	24	9	will	will	MD
cord-018182-lleti89n	24	10	often	often	RB
cord-018182-lleti89n	24	11	have	have	VB
cord-018182-lleti89n	24	12	signs	sign	NNS
cord-018182-lleti89n	24	13	of	of	IN
cord-018182-lleti89n	24	14	increased	increase	VBN
cord-018182-lleti89n	24	15	work	work	NN
cord-018182-lleti89n	24	16	of	of	IN
cord-018182-lleti89n	24	17	breathing	breathe	VBG
cord-018182-lleti89n	24	18	including	include	VBG
cord-018182-lleti89n	24	19	accessory	accessory	JJ
cord-018182-lleti89n	24	20	muscle	muscle	NN
cord-018182-lleti89n	24	21	use	use	NN
cord-018182-lleti89n	24	22	,	,	,
cord-018182-lleti89n	24	23	paradoxical	paradoxical	JJ
cord-018182-lleti89n	24	24	chest	chest	NN
cord-018182-lleti89n	24	25	or	or	CC
cord-018182-lleti89n	24	26	abdominal	abdominal	JJ
cord-018182-lleti89n	24	27	wall	wall	NN
cord-018182-lleti89n	24	28	movements	movement	NNS
cord-018182-lleti89n	24	29	,	,	,
cord-018182-lleti89n	24	30	cyanosis	cyanosis	NN
cord-018182-lleti89n	24	31	,	,	,
cord-018182-lleti89n	24	32	altered	alter	VBN
cord-018182-lleti89n	24	33	mental	mental	JJ
cord-018182-lleti89n	24	34	status	status	NN
cord-018182-lleti89n	24	35	,	,	,
cord-018182-lleti89n	24	36	and	and	CC
cord-018182-lleti89n	24	37	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	24	38	instability	instability	NN
cord-018182-lleti89n	24	39	[	[	-LRB-
cord-018182-lleti89n	24	40	8	8	CD
cord-018182-lleti89n	24	41	]	]	-RRB-
cord-018182-lleti89n	24	42	.	.	.
cord-018182-lleti89n	25	1	A	a	DT
cord-018182-lleti89n	25	2	focused	focused	JJ
cord-018182-lleti89n	25	3	cardiopulmonary	cardiopulmonary	JJ
cord-018182-lleti89n	25	4	exam	exam	NN
cord-018182-lleti89n	25	5	is	be	VBZ
cord-018182-lleti89n	25	6	recommended	recommend	VBN
cord-018182-lleti89n	25	7	with	with	IN
cord-018182-lleti89n	25	8	close	close	JJ
cord-018182-lleti89n	25	9	attention	attention	NN
cord-018182-lleti89n	25	10	to	to	IN
cord-018182-lleti89n	25	11	work	work	NN
cord-018182-lleti89n	25	12	of	of	IN
cord-018182-lleti89n	25	13	breathing	breathing	NN
cord-018182-lleti89n	25	14	including	include	VBG
cord-018182-lleti89n	25	15	use	use	NN
cord-018182-lleti89n	25	16	of	of	IN
cord-018182-lleti89n	25	17	accessory	accessory	JJ
cord-018182-lleti89n	25	18	respiratory	respiratory	JJ
cord-018182-lleti89n	25	19	muscles	muscle	NNS
cord-018182-lleti89n	25	20	,	,	,
cord-018182-lleti89n	25	21	ability	ability	NN
cord-018182-lleti89n	25	22	to	to	TO
cord-018182-lleti89n	25	23	speak	speak	VB
cord-018182-lleti89n	25	24	in	in	IN
cord-018182-lleti89n	25	25	complete	complete	JJ
cord-018182-lleti89n	25	26	sentences	sentence	NNS
cord-018182-lleti89n	25	27	,	,	,
cord-018182-lleti89n	25	28	degree	degree	NN
cord-018182-lleti89n	25	29	of	of	IN
cord-018182-lleti89n	25	30	air	air	NN
cord-018182-lleti89n	25	31	movement	movement	NN
cord-018182-lleti89n	25	32	and	and	CC
cord-018182-lleti89n	25	33	adventitious	adventitious	JJ
cord-018182-lleti89n	25	34	lung	lung	NN
cord-018182-lleti89n	25	35	sounds	sound	VBZ
cord-018182-lleti89n	25	36	on	on	IN
cord-018182-lleti89n	25	37	auscultation	auscultation	NN
cord-018182-lleti89n	25	38	,	,	,
cord-018182-lleti89n	25	39	evidence	evidence	NN
cord-018182-lleti89n	25	40	of	of	IN
cord-018182-lleti89n	25	41	volume	volume	NN
cord-018182-lleti89n	25	42	overload	overload	NN
cord-018182-lleti89n	25	43	including	include	VBG
cord-018182-lleti89n	25	44	jugular	jugular	NN
cord-018182-lleti89n	25	45	venous	venous	JJ
cord-018182-lleti89n	25	46	distension	distension	NN
cord-018182-lleti89n	25	47	(	(	-LRB-
cord-018182-lleti89n	25	48	JVD	JVD	NNP
cord-018182-lleti89n	25	49	)	)	-RRB-
cord-018182-lleti89n	25	50	and	and	CC
cord-018182-lleti89n	25	51	peripheral	peripheral	JJ
cord-018182-lleti89n	25	52	edema	edema	NN
cord-018182-lleti89n	25	53	,	,	,
cord-018182-lleti89n	25	54	presence	presence	NN
cord-018182-lleti89n	25	55	of	of	IN
cord-018182-lleti89n	25	56	cardiac	cardiac	JJ
cord-018182-lleti89n	25	57	arrhythmias	arrhythmia	NNS
cord-018182-lleti89n	25	58	,	,	,
cord-018182-lleti89n	25	59	and	and	CC
cord-018182-lleti89n	25	60	cyanosis	cyanosis	NN
cord-018182-lleti89n	25	61	.	.	.
cord-018182-lleti89n	26	1	The	the	DT
cord-018182-lleti89n	26	2	patient	patient	NN
cord-018182-lleti89n	26	3	's	's	POS
cord-018182-lleti89n	26	4	mental	mental	JJ
cord-018182-lleti89n	26	5	status	status	NN
cord-018182-lleti89n	26	6	and	and	CC
cord-018182-lleti89n	26	7	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	26	8	stability	stability	NN
cord-018182-lleti89n	26	9	should	should	MD
cord-018182-lleti89n	26	10	also	also	RB
cord-018182-lleti89n	26	11	be	be	VB
cord-018182-lleti89n	26	12	assessed	assess	VBN
cord-018182-lleti89n	26	13	.	.	.
cord-018182-lleti89n	27	1	The	the	DT
cord-018182-lleti89n	27	2	severity	severity	NN
cord-018182-lleti89n	27	3	of	of	IN
cord-018182-lleti89n	27	4	AECOPD	AECOPD	NNP
cord-018182-lleti89n	27	5	varies	vary	VBZ
cord-018182-lleti89n	27	6	greatly	greatly	RB
cord-018182-lleti89n	27	7	.	.	.
cord-018182-lleti89n	28	1	Mild	mild	JJ
cord-018182-lleti89n	28	2	exacerbations	exacerbation	NNS
cord-018182-lleti89n	28	3	may	may	MD
cord-018182-lleti89n	28	4	be	be	VB
cord-018182-lleti89n	28	5	managed	manage	VBN
cord-018182-lleti89n	28	6	as	as	IN
cord-018182-lleti89n	28	7	an	an	DT
cord-018182-lleti89n	28	8	outpatient	outpatient	NN
cord-018182-lleti89n	28	9	whereas	whereas	IN
cord-018182-lleti89n	28	10	others	other	NNS
cord-018182-lleti89n	28	11	with	with	IN
cord-018182-lleti89n	28	12	the	the	DT
cord-018182-lleti89n	28	13	most	most	RBS
cord-018182-lleti89n	28	14	severe	severe	JJ
cord-018182-lleti89n	28	15	presentations	presentation	NNS
cord-018182-lleti89n	28	16	will	will	MD
cord-018182-lleti89n	28	17	require	require	VB
cord-018182-lleti89n	28	18	close	close	JJ
cord-018182-lleti89n	28	19	monitoring	monitoring	NN
cord-018182-lleti89n	28	20	in	in	IN
cord-018182-lleti89n	28	21	the	the	DT
cord-018182-lleti89n	28	22	ICU	ICU	NNP
cord-018182-lleti89n	28	23	setting	setting	NN
cord-018182-lleti89n	28	24	.	.	.
cord-018182-lleti89n	29	1	Table	table	NN
cord-018182-lleti89n	29	2	13	13	CD
cord-018182-lleti89n	29	3	.1	.1	NN
cord-018182-lleti89n	29	4	summarizes	summarize	VBZ
cord-018182-lleti89n	29	5	indications	indication	NNS
cord-018182-lleti89n	29	6	for	for	IN
cord-018182-lleti89n	29	7	ICU	ICU	NNP
cord-018182-lleti89n	29	8	admission	admission	NN
cord-018182-lleti89n	29	9	.	.	.
cord-018182-lleti89n	30	1	The	the	DT
cord-018182-lleti89n	30	2	BAP-65	BAP-65	NNP
cord-018182-lleti89n	30	3	is	be	VBZ
cord-018182-lleti89n	30	4	a	a	DT
cord-018182-lleti89n	30	5	novel	novel	JJ
cord-018182-lleti89n	30	6	scoring	scoring	NN
cord-018182-lleti89n	30	7	system	system	NN
cord-018182-lleti89n	30	8	developed	develop	VBD
cord-018182-lleti89n	30	9	to	to	TO
cord-018182-lleti89n	30	10	risk	risk	NN
cord-018182-lleti89n	30	11	stratify	stratify	VB
cord-018182-lleti89n	30	12	the	the	DT
cord-018182-lleti89n	30	13	need	need	NN
cord-018182-lleti89n	30	14	for	for	IN
cord-018182-lleti89n	30	15	mechanical	mechanical	JJ
cord-018182-lleti89n	30	16	intubation	intubation	NN
cord-018182-lleti89n	30	17	and	and	CC
cord-018182-lleti89n	30	18	mortality	mortality	NN
cord-018182-lleti89n	30	19	rate	rate	NN
cord-018182-lleti89n	30	20	of	of	IN
cord-018182-lleti89n	30	21	hospitalized	hospitalize	VBN
cord-018182-lleti89n	30	22	patients	patient	NNS
cord-018182-lleti89n	30	23	with	with	IN
cord-018182-lleti89n	30	24	AECOPD	AECOPD	NNP
cord-018182-lleti89n	30	25	(	(	-LRB-
cord-018182-lleti89n	30	26	see	see	VB
cord-018182-lleti89n	30	27	Table	Table	NNP
cord-018182-lleti89n	30	28	13	13	CD
cord-018182-lleti89n	30	29	.2	.2	CD
cord-018182-lleti89n	30	30	)	)	-RRB-
cord-018182-lleti89n	30	31	.	.	.
cord-018182-lleti89n	31	1	Although	although	IN
cord-018182-lleti89n	31	2	useful	useful	JJ
cord-018182-lleti89n	31	3	as	as	IN
cord-018182-lleti89n	31	4	a	a	DT
cord-018182-lleti89n	31	5	risk	risk	NN
cord-018182-lleti89n	31	6	stratification	stratification	NN
cord-018182-lleti89n	31	7	tool	tool	NN
cord-018182-lleti89n	31	8	,	,	,
cord-018182-lleti89n	31	9	the	the	DT
cord-018182-lleti89n	31	10	decision	decision	NN
cord-018182-lleti89n	31	11	to	to	TO
cord-018182-lleti89n	31	12	admit	admit	VB
cord-018182-lleti89n	31	13	a	a	DT
cord-018182-lleti89n	31	14	patient	patient	NN
cord-018182-lleti89n	31	15	to	to	IN
cord-018182-lleti89n	31	16	the	the	DT
cord-018182-lleti89n	31	17	ICU	ICU	NNP
cord-018182-lleti89n	31	18	should	should	MD
cord-018182-lleti89n	31	19	be	be	VB
cord-018182-lleti89n	31	20	based	base	VBN
cord-018182-lleti89n	31	21	on	on	IN
cord-018182-lleti89n	31	22	individual	individual	JJ
cord-018182-lleti89n	31	23	patient	patient	NN
cord-018182-lleti89n	31	24	presentation	presentation	NN
cord-018182-lleti89n	31	25	and	and	CC
cord-018182-lleti89n	31	26	treatment	treatment	NN
cord-018182-lleti89n	31	27	center	center	NN
cord-018182-lleti89n	31	28	capabilities	capability	NNS
cord-018182-lleti89n	31	29	.	.	.
cord-018182-lleti89n	32	1	The	the	DT
cord-018182-lleti89n	32	2	assessment	assessment	NN
cord-018182-lleti89n	32	3	is	be	VBZ
cord-018182-lleti89n	32	4	based	base	VBN
cord-018182-lleti89n	32	5	on	on	IN
cord-018182-lleti89n	32	6	the	the	DT
cord-018182-lleti89n	32	7	presence	presence	NN
cord-018182-lleti89n	32	8	of	of	IN
cord-018182-lleti89n	32	9	any	any	DT
cord-018182-lleti89n	32	10	of	of	IN
cord-018182-lleti89n	32	11	the	the	DT
cord-018182-lleti89n	32	12	following	following	NN
cord-018182-lleti89n	32	13	,	,	,
cord-018182-lleti89n	32	14	with	with	IN
cord-018182-lleti89n	32	15	increased	increase	VBN
cord-018182-lleti89n	32	16	scores	score	NNS
cord-018182-lleti89n	32	17	portending	portend	VBG
cord-018182-lleti89n	32	18	a	a	DT
cord-018182-lleti89n	32	19	worse	bad	JJR
cord-018182-lleti89n	32	20	prognosis	prognosis	NN
cord-018182-lleti89n	32	21	[	[	-LRB-
cord-018182-lleti89n	32	22	10	10	CD
cord-018182-lleti89n	32	23	]	]	-RRB-
cord-018182-lleti89n	32	24	:	:	:
cord-018182-lleti89n	32	25	 	 	_SP
cord-018182-lleti89n	33	1	The	the	DT
cord-018182-lleti89n	33	2	initial	initial	JJ
cord-018182-lleti89n	33	3	evaluation	evaluation	NN
cord-018182-lleti89n	33	4	of	of	IN
cord-018182-lleti89n	33	5	a	a	DT
cord-018182-lleti89n	33	6	patient	patient	NN
cord-018182-lleti89n	33	7	with	with	IN
cord-018182-lleti89n	33	8	suspected	suspect	VBN
cord-018182-lleti89n	33	9	AECOPD	AECOPD	NNP
cord-018182-lleti89n	33	10	admitted	admit	VBD
cord-018182-lleti89n	33	11	to	to	IN
cord-018182-lleti89n	33	12	the	the	DT
cord-018182-lleti89n	33	13	ICU	ICU	NNP
cord-018182-lleti89n	33	14	should	should	MD
cord-018182-lleti89n	33	15	be	be	VB
cord-018182-lleti89n	33	16	focused	focus	VBN
cord-018182-lleti89n	33	17	on	on	IN
cord-018182-lleti89n	33	18	assessing	assess	VBG
cord-018182-lleti89n	33	19	severity	severity	NN
cord-018182-lleti89n	33	20	of	of	IN
cord-018182-lleti89n	33	21	illness	illness	NN
cord-018182-lleti89n	33	22	,	,	,
cord-018182-lleti89n	33	23	need	need	VBP
cord-018182-lleti89n	33	24	for	for	IN
cord-018182-lleti89n	33	25	possible	possible	JJ
cord-018182-lleti89n	33	26	ventilatory	ventilatory	JJ
cord-018182-lleti89n	33	27	support	support	NN
cord-018182-lleti89n	33	28	,	,	,
cord-018182-lleti89n	33	29	and	and	CC
cord-018182-lleti89n	33	30	exclusion	exclusion	NN
cord-018182-lleti89n	33	31	of	of	IN
cord-018182-lleti89n	33	32	other	other	JJ
cord-018182-lleti89n	33	33	possible	possible	JJ
cord-018182-lleti89n	33	34	causes	cause	NNS
cord-018182-lleti89n	33	35	for	for	IN
cord-018182-lleti89n	33	36	respiratory	respiratory	JJ
cord-018182-lleti89n	33	37	distress	distress	NN
cord-018182-lleti89n	33	38	.	.	.
cord-018182-lleti89n	34	1	For	for	IN
cord-018182-lleti89n	34	2	all	all	DT
cord-018182-lleti89n	34	3	patients	patient	NNS
cord-018182-lleti89n	34	4	admitted	admit	VBN
cord-018182-lleti89n	34	5	to	to	IN
cord-018182-lleti89n	34	6	the	the	DT
cord-018182-lleti89n	34	7	ICU	ICU	NNP
cord-018182-lleti89n	34	8	with	with	IN
cord-018182-lleti89n	34	9	suspected	suspect	VBN
cord-018182-lleti89n	34	10	AECOPD	AECOPD	NNP
cord-018182-lleti89n	34	11	,	,	,
cord-018182-lleti89n	34	12	we	-PRON-	PRP
cord-018182-lleti89n	34	13	recommend	recommend	VBP
cord-018182-lleti89n	34	14	the	the	DT
cord-018182-lleti89n	34	15	following	follow	VBG
cord-018182-lleti89n	34	16	diagnostic	diagnostic	JJ
cord-018182-lleti89n	34	17	elements	element	NNS
cord-018182-lleti89n	34	18	[	[	-LRB-
cord-018182-lleti89n	34	19	8	8	CD
cord-018182-lleti89n	34	20	]	]	-RRB-
cord-018182-lleti89n	34	21	:	:	:
cord-018182-lleti89n	35	1	•	•	NNP
cord-018182-lleti89n	36	1	Continuous	continuous	JJ
cord-018182-lleti89n	36	2	pulse	pulse	NN
cord-018182-lleti89n	36	3	oximetry	oximetry	NN
cord-018182-lleti89n	37	1	•	•	NNP
cord-018182-lleti89n	38	1	Arterial	arterial	JJ
cord-018182-lleti89n	38	2	blood	blood	NN
cord-018182-lleti89n	38	3	gas	gas	NN
cord-018182-lleti89n	38	4	(	(	-LRB-
cord-018182-lleti89n	38	5	ABG	ABG	NNP
cord-018182-lleti89n	38	6	)	)	-RRB-
cord-018182-lleti89n	39	1	•	•	NNP
cord-018182-lleti89n	40	1	Chest	chest	NN
cord-018182-lleti89n	40	2	radiograph	radiograph	NN
cord-018182-lleti89n	41	1	•	•	NNP
cord-018182-lleti89n	42	1	Electrocardiogram	Electrocardiogram	NNP
cord-018182-lleti89n	43	1	•	•	NNP
cord-018182-lleti89n	44	1	Basic	basic	JJ
cord-018182-lleti89n	44	2	metabolic	metabolic	JJ
cord-018182-lleti89n	44	3	panel	panel	NN
cord-018182-lleti89n	44	4	(	(	-LRB-
cord-018182-lleti89n	44	5	BMP	BMP	NNP
cord-018182-lleti89n	44	6	)	)	-RRB-
cord-018182-lleti89n	45	1	•	•	NNP
cord-018182-lleti89n	46	1	Complete	complete	JJ
cord-018182-lleti89n	46	2	blood	blood	NN
cord-018182-lleti89n	46	3	count	count	NN
cord-018182-lleti89n	46	4	(	(	-LRB-
cord-018182-lleti89n	46	5	CBC	CBC	NNP
cord-018182-lleti89n	46	6	)	)	-RRB-
cord-018182-lleti89n	47	1	•	•	NNP
cord-018182-lleti89n	48	1	Sputum	sputum	NN
cord-018182-lleti89n	48	2	culture	culture	NN
cord-018182-lleti89n	48	3	(	(	-LRB-
cord-018182-lleti89n	48	4	consider	consider	VB
cord-018182-lleti89n	48	5	induced	induce	VBN
cord-018182-lleti89n	48	6	sputum	sputum	NN
cord-018182-lleti89n	48	7	sample	sample	NN
cord-018182-lleti89n	48	8	for	for	IN
cord-018182-lleti89n	48	9	patients	patient	NNS
cord-018182-lleti89n	48	10	with	with	IN
cord-018182-lleti89n	48	11	minimal	minimal	JJ
cord-018182-lleti89n	48	12	sputum	sputum	NN
cord-018182-lleti89n	48	13	production	production	NN
cord-018182-lleti89n	48	14	)	)	-RRB-
cord-018182-lleti89n	49	1	This	this	DT
cord-018182-lleti89n	49	2	initial	initial	JJ
cord-018182-lleti89n	49	3	workup	workup	NN
cord-018182-lleti89n	49	4	may	may	MD
cord-018182-lleti89n	49	5	be	be	VB
cord-018182-lleti89n	49	6	useful	useful	JJ
cord-018182-lleti89n	49	7	in	in	IN
cord-018182-lleti89n	49	8	differentiating	differentiate	VBG
cord-018182-lleti89n	49	9	COPD	COPD	NNP
cord-018182-lleti89n	49	10	from	from	IN
cord-018182-lleti89n	49	11	other	other	JJ
cord-018182-lleti89n	49	12	cardiac	cardiac	JJ
cord-018182-lleti89n	49	13	and	and	CC
cord-018182-lleti89n	49	14	pulmonary	pulmonary	JJ
cord-018182-lleti89n	49	15	causes	cause	NNS
cord-018182-lleti89n	49	16	of	of	IN
cord-018182-lleti89n	49	17	respiratory	respiratory	JJ
cord-018182-lleti89n	49	18	failure	failure	NN
cord-018182-lleti89n	49	19	.	.	.
cord-018182-lleti89n	50	1	Important	important	JJ
cord-018182-lleti89n	50	2	differential	differential	JJ
cord-018182-lleti89n	50	3	diagnoses	diagnosis	NNS
cord-018182-lleti89n	50	4	in	in	IN
cord-018182-lleti89n	50	5	patients	patient	NNS
cord-018182-lleti89n	50	6	with	with	IN
cord-018182-lleti89n	50	7	severe	severe	JJ
cord-018182-lleti89n	50	8	dyspnea	dyspnea	NN
cord-018182-lleti89n	50	9	and/or	and/or	CC
cord-018182-lleti89n	50	10	impending	impend	VBG
cord-018182-lleti89n	50	11	respiratory	respiratory	JJ
cord-018182-lleti89n	50	12	failure	failure	NN
cord-018182-lleti89n	50	13	include	include	VBP
cord-018182-lleti89n	50	14	congestive	congestive	JJ
cord-018182-lleti89n	50	15	heart	heart	NN
cord-018182-lleti89n	50	16	failure	failure	NN
cord-018182-lleti89n	50	17	,	,	,
cord-018182-lleti89n	50	18	acute	acute	JJ
cord-018182-lleti89n	50	19	coronary	coronary	JJ
cord-018182-lleti89n	50	20	syndrome	syndrome	NN
cord-018182-lleti89n	50	21	,	,	,
cord-018182-lleti89n	50	22	pulmonary	pulmonary	JJ
cord-018182-lleti89n	50	23	embolism	embolism	NN
cord-018182-lleti89n	50	24	,	,	,
cord-018182-lleti89n	50	25	cardiac	cardiac	JJ
cord-018182-lleti89n	50	26	arrhythmia	arrhythmia	NN
cord-018182-lleti89n	50	27	,	,	,
cord-018182-lleti89n	50	28	pneumothorax	pneumothorax	NN
cord-018182-lleti89n	50	29	,	,	,
cord-018182-lleti89n	50	30	pleural	pleural	JJ
cord-018182-lleti89n	50	31	effusion	effusion	NN
cord-018182-lleti89n	50	32	,	,	,
cord-018182-lleti89n	50	33	acute	acute	JJ
cord-018182-lleti89n	50	34	infectious	infectious	JJ
cord-018182-lleti89n	50	35	processes	process	NNS
cord-018182-lleti89n	50	36	such	such	JJ
cord-018182-lleti89n	50	37	as	as	IN
cord-018182-lleti89n	50	38	bacterial	bacterial	JJ
cord-018182-lleti89n	50	39	or	or	CC
cord-018182-lleti89n	50	40	viral	viral	JJ
cord-018182-lleti89n	50	41	pneumonia	pneumonia	NN
cord-018182-lleti89n	50	42	,	,	,
cord-018182-lleti89n	50	43	and	and	CC
cord-018182-lleti89n	50	44	exacerbations	exacerbation	NNS
cord-018182-lleti89n	50	45	of	of	IN
cord-018182-lleti89n	50	46	other	other	JJ
cord-018182-lleti89n	50	47	underlying	underlying	JJ
cord-018182-lleti89n	50	48	pulmonary	pulmonary	JJ
cord-018182-lleti89n	50	49	conditions	condition	NNS
cord-018182-lleti89n	50	50	such	such	JJ
cord-018182-lleti89n	50	51	as	as	IN
cord-018182-lleti89n	50	52	interstitial	interstitial	JJ
cord-018182-lleti89n	50	53	lung	lung	NN
cord-018182-lleti89n	50	54	disease	disease	NN
cord-018182-lleti89n	50	55	.	.	.
cord-018182-lleti89n	51	1	These	these	DT
cord-018182-lleti89n	51	2	conditions	condition	NNS
cord-018182-lleti89n	51	3	may	may	MD
cord-018182-lleti89n	51	4	coexist	coexist	VB
cord-018182-lleti89n	51	5	with	with	IN
cord-018182-lleti89n	51	6	or	or	CC
cord-018182-lleti89n	51	7	precipitate	precipitate	VB
cord-018182-lleti89n	51	8	AECOPD	AECOPD	NNP
cord-018182-lleti89n	51	9	.	.	.
cord-018182-lleti89n	52	1	Thus	thus	RB
cord-018182-lleti89n	52	2	,	,	,
cord-018182-lleti89n	52	3	it	-PRON-	PRP
cord-018182-lleti89n	52	4	is	be	VBZ
cord-018182-lleti89n	52	5	important	important	JJ
cord-018182-lleti89n	52	6	to	to	TO
cord-018182-lleti89n	52	7	pursue	pursue	VB
cord-018182-lleti89n	52	8	a	a	DT
cord-018182-lleti89n	52	9	thorough	thorough	JJ
cord-018182-lleti89n	52	10	diagnostic	diagnostic	JJ
cord-018182-lleti89n	52	11	workup	workup	NN
cord-018182-lleti89n	52	12	in	in	IN
cord-018182-lleti89n	52	13	tandem	tandem	NN
cord-018182-lleti89n	52	14	with	with	IN
cord-018182-lleti89n	52	15	ongoing	ongoing	JJ
cord-018182-lleti89n	52	16	therapeutic	therapeutic	JJ
cord-018182-lleti89n	52	17	interventions	intervention	NNS
cord-018182-lleti89n	52	18	.	.	.
cord-018182-lleti89n	53	1	Additional	additional	JJ
cord-018182-lleti89n	53	2	diagnostic	diagnostic	JJ
cord-018182-lleti89n	53	3	measures	measure	NNS
cord-018182-lleti89n	53	4	including	include	VBG
cord-018182-lleti89n	53	5	chest	chest	NN
cord-018182-lleti89n	53	6	computerized	computerized	JJ
cord-018182-lleti89n	53	7	tomography	tomography	NN
cord-018182-lleti89n	53	8	(	(	-LRB-
cord-018182-lleti89n	53	9	CT	CT	NNP
cord-018182-lleti89n	53	10	)	)	-RRB-
cord-018182-lleti89n	53	11	,	,	,
cord-018182-lleti89n	53	12	echocardiography	echocardiography	NN
cord-018182-lleti89n	53	13	,	,	,
cord-018182-lleti89n	53	14	cardiac	cardiac	JJ
cord-018182-lleti89n	53	15	biomarkers	biomarker	NNS
cord-018182-lleti89n	53	16	,	,	,
cord-018182-lleti89n	53	17	brain	brain	NN
cord-018182-lleti89n	53	18	naturetic	naturetic	NNP
cord-018182-lleti89n	53	19	peptide	peptide	NNP
cord-018182-lleti89n	53	20	(	(	-LRB-
cord-018182-lleti89n	53	21	BNP	BNP	NNP
cord-018182-lleti89n	53	22	)	)	-RRB-
cord-018182-lleti89n	53	23	,	,	,
cord-018182-lleti89n	53	24	and	and	CC
cord-018182-lleti89n	53	25	respiratory	respiratory	JJ
cord-018182-lleti89n	53	26	viral	viral	JJ
cord-018182-lleti89n	53	27	molecular	molecular	JJ
cord-018182-lleti89n	53	28	testing	testing	NN
cord-018182-lleti89n	53	29	should	should	MD
cord-018182-lleti89n	53	30	be	be	VB
cord-018182-lleti89n	53	31	considered	consider	VBN
cord-018182-lleti89n	53	32	in	in	IN
cord-018182-lleti89n	53	33	the	the	DT
cord-018182-lleti89n	53	34	appropriate	appropriate	JJ
cord-018182-lleti89n	53	35	clinical	clinical	JJ
cord-018182-lleti89n	53	36	setting	setting	NN
cord-018182-lleti89n	53	37	.	.	.
cord-018182-lleti89n	54	1	Spirometry	Spirometry	NNP
cord-018182-lleti89n	54	2	during	during	IN
cord-018182-lleti89n	54	3	an	an	DT
cord-018182-lleti89n	54	4	acute	acute	JJ
cord-018182-lleti89n	54	5	exacerbation	exacerbation	NN
cord-018182-lleti89n	54	6	is	be	VBZ
cord-018182-lleti89n	54	7	not	not	RB
cord-018182-lleti89n	54	8	recommended	recommend	VBN
cord-018182-lleti89n	54	9	as	as	IN
cord-018182-lleti89n	54	10	it	-PRON-	PRP
cord-018182-lleti89n	54	11	is	be	VBZ
cord-018182-lleti89n	54	12	likely	likely	JJ
cord-018182-lleti89n	54	13	to	to	TO
cord-018182-lleti89n	54	14	be	be	VB
cord-018182-lleti89n	54	15	both	both	DT
cord-018182-lleti89n	54	16	difficult	difficult	JJ
cord-018182-lleti89n	54	17	for	for	IN
cord-018182-lleti89n	54	18	the	the	DT
cord-018182-lleti89n	54	19	patient	patient	NN
cord-018182-lleti89n	54	20	to	to	TO
cord-018182-lleti89n	54	21	perform	perform	VB
cord-018182-lleti89n	54	22	and	and	CC
cord-018182-lleti89n	54	23	provide	provide	VB
cord-018182-lleti89n	54	24	an	an	DT
cord-018182-lleti89n	54	25	inaccurate	inaccurate	JJ
cord-018182-lleti89n	54	26	assessment	assessment	NN
cord-018182-lleti89n	54	27	of	of	IN
cord-018182-lleti89n	54	28	lung	lung	NN
cord-018182-lleti89n	54	29	function	function	NN
cord-018182-lleti89n	54	30	.	.	.
cord-018182-lleti89n	55	1	Systemic	systemic	JJ
cord-018182-lleti89n	55	2	glucocorticoids	glucocorticoid	NNS
cord-018182-lleti89n	55	3	are	be	VBP
cord-018182-lleti89n	55	4	considered	consider	VBN
cord-018182-lleti89n	55	5	a	a	DT
cord-018182-lleti89n	55	6	cornerstone	cornerstone	NN
cord-018182-lleti89n	55	7	of	of	IN
cord-018182-lleti89n	55	8	therapy	therapy	NN
cord-018182-lleti89n	55	9	in	in	IN
cord-018182-lleti89n	55	10	AECOPD	AECOPD	NNP
cord-018182-lleti89n	55	11	,	,	,
cord-018182-lleti89n	55	12	particularly	particularly	RB
cord-018182-lleti89n	55	13	in	in	IN
cord-018182-lleti89n	55	14	patients	patient	NNS
cord-018182-lleti89n	55	15	ill	ill	JJ
cord-018182-lleti89n	55	16	enough	enough	RB
cord-018182-lleti89n	55	17	to	to	TO
cord-018182-lleti89n	55	18	warrant	warrant	VB
cord-018182-lleti89n	55	19	ICU	ICU	NNP
cord-018182-lleti89n	55	20	admission	admission	NN
cord-018182-lleti89n	55	21	.	.	.
cord-018182-lleti89n	56	1	Although	although	IN
cord-018182-lleti89n	56	2	the	the	DT
cord-018182-lleti89n	56	3	optimal	optimal	JJ
cord-018182-lleti89n	56	4	formulation	formulation	NN
cord-018182-lleti89n	56	5	,	,	,
cord-018182-lleti89n	56	6	duration	duration	NN
cord-018182-lleti89n	56	7	,	,	,
cord-018182-lleti89n	56	8	and	and	CC
cord-018182-lleti89n	56	9	dosage	dosage	NN
cord-018182-lleti89n	56	10	of	of	IN
cord-018182-lleti89n	56	11	treatment	treatment	NN
cord-018182-lleti89n	56	12	remains	remain	VBZ
cord-018182-lleti89n	56	13	unclear	unclear	JJ
cord-018182-lleti89n	56	14	,	,	,
cord-018182-lleti89n	56	15	studies	study	NNS
cord-018182-lleti89n	56	16	have	have	VBP
cord-018182-lleti89n	56	17	shown	show	VBN
cord-018182-lleti89n	56	18	that	that	IN
cord-018182-lleti89n	56	19	systemic	systemic	JJ
cord-018182-lleti89n	56	20	steroids	steroid	NNS
cord-018182-lleti89n	56	21	accelerate	accelerate	VBP
cord-018182-lleti89n	56	22	improvement	improvement	NN
cord-018182-lleti89n	56	23	in	in	IN
cord-018182-lleti89n	56	24	airflow	airflow	NN
cord-018182-lleti89n	56	25	,	,	,
cord-018182-lleti89n	56	26	gas	gas	NN
cord-018182-lleti89n	56	27	exchange	exchange	NN
cord-018182-lleti89n	56	28	,	,	,
cord-018182-lleti89n	56	29	and	and	CC
cord-018182-lleti89n	56	30	symptoms	symptom	NNS
cord-018182-lleti89n	56	31	in	in	IN
cord-018182-lleti89n	56	32	addition	addition	NN
cord-018182-lleti89n	56	33	to	to	IN
cord-018182-lleti89n	56	34	reducing	reduce	VBG
cord-018182-lleti89n	56	35	the	the	DT
cord-018182-lleti89n	56	36	rate	rate	NN
cord-018182-lleti89n	56	37	of	of	IN
cord-018182-lleti89n	56	38	treatment	treatment	NN
cord-018182-lleti89n	56	39	failure	failure	NN
cord-018182-lleti89n	56	40	[	[	-LRB-
cord-018182-lleti89n	56	41	11	11	CD
cord-018182-lleti89n	56	42	]	]	-RRB-
cord-018182-lleti89n	56	43	.	.	.
cord-018182-lleti89n	57	1	A	a	DT
cord-018182-lleti89n	57	2	trial	trial	NN
cord-018182-lleti89n	57	3	by	by	IN
cord-018182-lleti89n	57	4	Niewoehner	Niewoehner	NNP
cord-018182-lleti89n	57	5	[	[	-LRB-
cord-018182-lleti89n	57	6	9	9	CD
cord-018182-lleti89n	57	7	]	]	-RRB-
cord-018182-lleti89n	58	1	Note	note	VB
cord-018182-lleti89n	58	2	:	:	:
cord-018182-lleti89n	58	3	Indications	indication	NNS
cord-018182-lleti89n	58	4	will	will	MD
cord-018182-lleti89n	58	5	vary	vary	VB
cord-018182-lleti89n	58	6	by	by	IN
cord-018182-lleti89n	58	7	institution	institution	NN
cord-018182-lleti89n	58	8	and	and	CC
cord-018182-lleti89n	58	9	ability	ability	NN
cord-018182-lleti89n	58	10	to	to	TO
cord-018182-lleti89n	58	11	do	do	VB
cord-018182-lleti89n	58	12	noninvasive	noninvasive	JJ
cord-018182-lleti89n	58	13	ventilation	ventilation	NN
cord-018182-lleti89n	58	14	outside	outside	IN
cord-018182-lleti89n	58	15	of	of	IN
cord-018182-lleti89n	58	16	the	the	DT
cord-018182-lleti89n	58	17	ICU	ICU	NNP
cord-018182-lleti89n	58	18	and	and	CC
cord-018182-lleti89n	58	19	colleagues	colleague	NNS
cord-018182-lleti89n	58	20	demonstrated	demonstrate	VBD
cord-018182-lleti89n	58	21	that	that	IN
cord-018182-lleti89n	58	22	there	there	EX
cord-018182-lleti89n	58	23	was	be	VBD
cord-018182-lleti89n	58	24	no	no	DT
cord-018182-lleti89n	58	25	benefit	benefit	NN
cord-018182-lleti89n	58	26	of	of	IN
cord-018182-lleti89n	58	27	8	8	CD
cord-018182-lleti89n	58	28	weeks	week	NNS
cord-018182-lleti89n	58	29	of	of	IN
cord-018182-lleti89n	58	30	steroid	steroid	NN
cord-018182-lleti89n	58	31	treatment	treatment	NN
cord-018182-lleti89n	58	32	compared	compare	VBN
cord-018182-lleti89n	58	33	to	to	IN
cord-018182-lleti89n	58	34	2	2	CD
cord-018182-lleti89n	58	35	weeks	week	NNS
cord-018182-lleti89n	58	36	[	[	-LRB-
cord-018182-lleti89n	58	37	12	12	CD
cord-018182-lleti89n	58	38	]	]	-RRB-
cord-018182-lleti89n	58	39	.	.	.
cord-018182-lleti89n	59	1	Although	although	IN
cord-018182-lleti89n	59	2	some	some	DT
cord-018182-lleti89n	59	3	studies	study	NNS
cord-018182-lleti89n	59	4	in	in	IN
cord-018182-lleti89n	59	5	patients	patient	NNS
cord-018182-lleti89n	59	6	with	with	IN
cord-018182-lleti89n	59	7	AECOPD	AECOPD	NNP
cord-018182-lleti89n	59	8	suggest	suggest	VBP
cord-018182-lleti89n	59	9	that	that	IN
cord-018182-lleti89n	59	10	a	a	DT
cord-018182-lleti89n	59	11	5-day	5-day	JJ
cord-018182-lleti89n	59	12	regimen	regimen	NN
cord-018182-lleti89n	59	13	of	of	IN
cord-018182-lleti89n	59	14	40	40	CD
cord-018182-lleti89n	59	15	mg	mg	NNS
cord-018182-lleti89n	59	16	of	of	IN
cord-018182-lleti89n	59	17	prednisone	prednisone	NNP
cord-018182-lleti89n	59	18	may	may	MD
cord-018182-lleti89n	59	19	be	be	VB
cord-018182-lleti89n	59	20	superior	superior	JJ
cord-018182-lleti89n	59	21	to	to	IN
cord-018182-lleti89n	59	22	14	14	CD
cord-018182-lleti89n	59	23	days	day	NNS
cord-018182-lleti89n	59	24	,	,	,
cord-018182-lleti89n	59	25	no	no	DT
cord-018182-lleti89n	59	26	trials	trial	NNS
cord-018182-lleti89n	59	27	have	have	VBP
cord-018182-lleti89n	59	28	clearly	clearly	RB
cord-018182-lleti89n	59	29	defined	define	VBN
cord-018182-lleti89n	59	30	the	the	DT
cord-018182-lleti89n	59	31	optimal	optimal	JJ
cord-018182-lleti89n	59	32	regimen	regimen	NN
cord-018182-lleti89n	59	33	for	for	IN
cord-018182-lleti89n	59	34	patients	patient	NNS
cord-018182-lleti89n	59	35	with	with	IN
cord-018182-lleti89n	59	36	severe	severe	JJ
cord-018182-lleti89n	59	37	exacerbations	exacerbation	NNS
cord-018182-lleti89n	59	38	requiring	require	VBG
cord-018182-lleti89n	59	39	ICU	ICU	NNP
cord-018182-lleti89n	59	40	admission	admission	NN
cord-018182-lleti89n	59	41	[	[	-LRB-
cord-018182-lleti89n	59	42	13	13	CD
cord-018182-lleti89n	59	43	]	]	-RRB-
cord-018182-lleti89n	59	44	.	.	.
cord-018182-lleti89n	60	1	In	in	IN
cord-018182-lleti89n	60	2	general	general	JJ
cord-018182-lleti89n	60	3	,	,	,
cord-018182-lleti89n	60	4	we	-PRON-	PRP
cord-018182-lleti89n	60	5	recommend	recommend	VBP
cord-018182-lleti89n	60	6	intravenous	intravenous	JJ
cord-018182-lleti89n	60	7	steroid	steroid	NN
cord-018182-lleti89n	60	8	administration	administration	NN
cord-018182-lleti89n	60	9	with	with	IN
cord-018182-lleti89n	60	10	0.5	0.5	CD
cord-018182-lleti89n	60	11	-	-	SYM
cord-018182-lleti89n	60	12	1.0	1.0	CD
cord-018182-lleti89n	60	13	mg	mg	NNP
cord-018182-lleti89n	60	14	/	/	SYM
cord-018182-lleti89n	60	15	kg	kg	NNP
cord-018182-lleti89n	60	16	methylprednisolone	methylprednisolone	NN
cord-018182-lleti89n	60	17	every	every	DT
cord-018182-lleti89n	60	18	6	6	CD
cord-018182-lleti89n	60	19	h	h	NN
cord-018182-lleti89n	60	20	for	for	IN
cord-018182-lleti89n	60	21	24	24	CD
cord-018182-lleti89n	60	22	h	h	NN
cord-018182-lleti89n	60	23	with	with	IN
cord-018182-lleti89n	60	24	tapering	taper	VBG
cord-018182-lleti89n	60	25	to	to	IN
cord-018182-lleti89n	60	26	twice	twice	RB
cord-018182-lleti89n	60	27	daily	daily	RB
cord-018182-lleti89n	61	1	and	and	CC
cord-018182-lleti89n	61	2	then	then	RB
cord-018182-lleti89n	61	3	daily	daily	RB
cord-018182-lleti89n	61	4	over	over	IN
cord-018182-lleti89n	61	5	the	the	DT
cord-018182-lleti89n	61	6	course	course	NN
cord-018182-lleti89n	61	7	of	of	IN
cord-018182-lleti89n	61	8	2	2	CD
cord-018182-lleti89n	61	9	-	-	SYM
cord-018182-lleti89n	61	10	3	3	CD
cord-018182-lleti89n	61	11	days	day	NNS
cord-018182-lleti89n	61	12	as	as	IN
cord-018182-lleti89n	61	13	tolerated	tolerate	VBN
cord-018182-lleti89n	61	14	for	for	IN
cord-018182-lleti89n	61	15	patients	patient	NNS
cord-018182-lleti89n	61	16	with	with	IN
cord-018182-lleti89n	61	17	severe	severe	JJ
cord-018182-lleti89n	61	18	exacerbations	exacerbation	NNS
cord-018182-lleti89n	61	19	admitted	admit	VBN
cord-018182-lleti89n	61	20	to	to	IN
cord-018182-lleti89n	61	21	the	the	DT
cord-018182-lleti89n	61	22	ICU	ICU	NNP
cord-018182-lleti89n	61	23	.	.	.
cord-018182-lleti89n	62	1	In	in	IN
cord-018182-lleti89n	62	2	general	general	JJ
cord-018182-lleti89n	62	3	,	,	,
cord-018182-lleti89n	62	4	the	the	DT
cord-018182-lleti89n	62	5	duration	duration	NN
cord-018182-lleti89n	62	6	of	of	IN
cord-018182-lleti89n	62	7	treatment	treatment	NN
cord-018182-lleti89n	62	8	should	should	MD
cord-018182-lleti89n	62	9	not	not	RB
cord-018182-lleti89n	62	10	exceed	exceed	VB
cord-018182-lleti89n	62	11	14	14	CD
cord-018182-lleti89n	62	12	days	day	NNS
cord-018182-lleti89n	62	13	.	.	.
cord-018182-lleti89n	63	1	Oral	oral	JJ
cord-018182-lleti89n	63	2	steroids	steroid	NNS
cord-018182-lleti89n	63	3	are	be	VBP
cord-018182-lleti89n	63	4	likely	likely	RB
cord-018182-lleti89n	63	5	equivalent	equivalent	JJ
cord-018182-lleti89n	63	6	to	to	IN
cord-018182-lleti89n	63	7	intravenous	intravenous	JJ
cord-018182-lleti89n	63	8	formulations	formulation	NNS
cord-018182-lleti89n	63	9	if	if	IN
cord-018182-lleti89n	63	10	the	the	DT
cord-018182-lleti89n	63	11	patient	patient	NN
cord-018182-lleti89n	63	12	can	can	MD
cord-018182-lleti89n	63	13	take	take	VB
cord-018182-lleti89n	63	14	pills	pill	NNS
cord-018182-lleti89n	63	15	by	by	IN
cord-018182-lleti89n	63	16	mouth	mouth	NN
cord-018182-lleti89n	63	17	.	.	.
cord-018182-lleti89n	64	1	Careful	careful	JJ
cord-018182-lleti89n	64	2	monitoring	monitoring	NN
cord-018182-lleti89n	64	3	for	for	IN
cord-018182-lleti89n	64	4	side	side	NN
cord-018182-lleti89n	64	5	effects	effect	NNS
cord-018182-lleti89n	64	6	including	include	VBG
cord-018182-lleti89n	64	7	alterations	alteration	NNS
cord-018182-lleti89n	64	8	in	in	IN
cord-018182-lleti89n	64	9	cognition	cognition	NN
cord-018182-lleti89n	64	10	,	,	,
cord-018182-lleti89n	64	11	hyperglycemia	hyperglycemia	NN
cord-018182-lleti89n	64	12	,	,	,
cord-018182-lleti89n	64	13	insomnia	insomnia	NN
cord-018182-lleti89n	64	14	,	,	,
cord-018182-lleti89n	64	15	fluid	fluid	JJ
cord-018182-lleti89n	64	16	retention	retention	NN
cord-018182-lleti89n	64	17	,	,	,
cord-018182-lleti89n	64	18	and	and	CC
cord-018182-lleti89n	64	19	peptic	peptic	JJ
cord-018182-lleti89n	64	20	ulcer	ulcer	NN
cord-018182-lleti89n	64	21	formation	formation	NN
cord-018182-lleti89n	64	22	is	be	VBZ
cord-018182-lleti89n	64	23	essential	essential	JJ
cord-018182-lleti89n	64	24	;	;	:
cord-018182-lleti89n	64	25	routine	routine	JJ
cord-018182-lleti89n	64	26	H2	H2	NNP
cord-018182-lleti89n	64	27	receptor	receptor	NN
cord-018182-lleti89n	64	28	antagonist	antagonist	NN
cord-018182-lleti89n	64	29	or	or	CC
cord-018182-lleti89n	64	30	proton	proton	NN
cord-018182-lleti89n	64	31	pump	pump	NN
cord-018182-lleti89n	64	32	inhibitor	inhibitor	NN
cord-018182-lleti89n	64	33	prescription	prescription	NN
cord-018182-lleti89n	64	34	should	should	MD
cord-018182-lleti89n	64	35	accompany	accompany	VB
cord-018182-lleti89n	64	36	steroid	steroid	NN
cord-018182-lleti89n	64	37	therapy	therapy	NN
cord-018182-lleti89n	64	38	in	in	IN
cord-018182-lleti89n	64	39	those	those	DT
cord-018182-lleti89n	64	40	admitted	admit	VBN
cord-018182-lleti89n	64	41	to	to	IN
cord-018182-lleti89n	64	42	the	the	DT
cord-018182-lleti89n	64	43	ICU	ICU	NNP
cord-018182-lleti89n	64	44	[	[	-LRB-
cord-018182-lleti89n	64	45	14	14	CD
cord-018182-lleti89n	64	46	]	]	-RRB-
cord-018182-lleti89n	64	47	.	.	.
cord-018182-lleti89n	65	1	There	there	EX
cord-018182-lleti89n	65	2	are	be	VBP
cord-018182-lleti89n	65	3	no	no	DT
cord-018182-lleti89n	65	4	controlled	control	VBN
cord-018182-lleti89n	65	5	trials	trial	NNS
cord-018182-lleti89n	65	6	documenting	document	VBG
cord-018182-lleti89n	65	7	efficacy	efficacy	NN
cord-018182-lleti89n	65	8	of	of	IN
cord-018182-lleti89n	65	9	these	these	DT
cord-018182-lleti89n	65	10	agents	agent	NNS
cord-018182-lleti89n	65	11	.	.	.
cord-018182-lleti89n	66	1	However	however	RB
cord-018182-lleti89n	66	2	,	,	,
cord-018182-lleti89n	66	3	in	in	IN
cord-018182-lleti89n	66	4	general	general	JJ
cord-018182-lleti89n	66	5	,	,	,
cord-018182-lleti89n	66	6	combination	combination	NN
cord-018182-lleti89n	66	7	short	short	RB
cord-018182-lleti89n	66	8	-	-	HYPH
cord-018182-lleti89n	66	9	acting	act	VBG
cord-018182-lleti89n	66	10	inhaled	inhale	VBN
cord-018182-lleti89n	66	11	beta-2	beta-2	NN
cord-018182-lleti89n	66	12	agonists	agonist	NNS
cord-018182-lleti89n	66	13	(	(	-LRB-
cord-018182-lleti89n	66	14	albuterol	albuterol	NNP
cord-018182-lleti89n	66	15	)	)	-RRB-
cord-018182-lleti89n	66	16	with	with	IN
cord-018182-lleti89n	66	17	or	or	CC
cord-018182-lleti89n	66	18	without	without	IN
cord-018182-lleti89n	66	19	shortacting	shortacte	VBG
cord-018182-lleti89n	66	20	anticholinergics	anticholinergics	NNPS
cord-018182-lleti89n	66	21	(	(	-LRB-
cord-018182-lleti89n	66	22	ipratropium	ipratropium	NNP
cord-018182-lleti89n	66	23	)	)	-RRB-
cord-018182-lleti89n	67	1	every	every	DT
cord-018182-lleti89n	67	2	2	2	CD
cord-018182-lleti89n	67	3	-	-	SYM
cord-018182-lleti89n	67	4	4	4	CD
cord-018182-lleti89n	67	5	h	h	NNP
cord-018182-lleti89n	67	6	are	be	VBP
cord-018182-lleti89n	67	7	recommended	recommend	VBN
cord-018182-lleti89n	67	8	for	for	IN
cord-018182-lleti89n	67	9	the	the	DT
cord-018182-lleti89n	67	10	treatment	treatment	NN
cord-018182-lleti89n	67	11	of	of	IN
cord-018182-lleti89n	67	12	AECOPD	AECOPD	NNP
cord-018182-lleti89n	67	13	[	[	-LRB-
cord-018182-lleti89n	67	14	1	1	CD
cord-018182-lleti89n	67	15	,	,	,
cord-018182-lleti89n	67	16	8	8	CD
cord-018182-lleti89n	67	17	]	]	-RRB-
cord-018182-lleti89n	67	18	.	.	.
cord-018182-lleti89n	68	1	There	there	EX
cord-018182-lleti89n	68	2	is	be	VBZ
cord-018182-lleti89n	68	3	no	no	DT
cord-018182-lleti89n	68	4	evidence	evidence	NN
cord-018182-lleti89n	68	5	to	to	TO
cord-018182-lleti89n	68	6	support	support	VB
cord-018182-lleti89n	68	7	combination	combination	NN
cord-018182-lleti89n	68	8	therapy	therapy	NN
cord-018182-lleti89n	68	9	,	,	,
cord-018182-lleti89n	68	10	although	although	IN
cord-018182-lleti89n	68	11	albuterol	albuterol	NNP
cord-018182-lleti89n	68	12	and	and	CC
cord-018182-lleti89n	68	13	ipratropium	ipratropium	NNP
cord-018182-lleti89n	68	14	are	be	VBP
cord-018182-lleti89n	68	15	frequently	frequently	RB
cord-018182-lleti89n	68	16	used	use	VBN
cord-018182-lleti89n	68	17	concurrently	concurrently	RB
cord-018182-lleti89n	68	18	,	,	,
cord-018182-lleti89n	68	19	particularly	particularly	RB
cord-018182-lleti89n	68	20	in	in	IN
cord-018182-lleti89n	68	21	patients	patient	NNS
cord-018182-lleti89n	68	22	requiring	require	VBG
cord-018182-lleti89n	68	23	ICU	ICU	NNP
cord-018182-lleti89n	68	24	admission	admission	NN
cord-018182-lleti89n	68	25	[	[	-LRB-
cord-018182-lleti89n	68	26	15	15	CD
cord-018182-lleti89n	68	27	]	]	-RRB-
cord-018182-lleti89n	68	28	.	.	.
cord-018182-lleti89n	69	1	For	for	IN
cord-018182-lleti89n	69	2	nonintubated	nonintubated	JJ
cord-018182-lleti89n	69	3	patients	patient	NNS
cord-018182-lleti89n	69	4	admitted	admit	VBN
cord-018182-lleti89n	69	5	to	to	IN
cord-018182-lleti89n	69	6	the	the	DT
cord-018182-lleti89n	69	7	ICU	ICU	NNP
cord-018182-lleti89n	69	8	,	,	,
cord-018182-lleti89n	69	9	we	-PRON-	PRP
cord-018182-lleti89n	69	10	recommend	recommend	VBP
cord-018182-lleti89n	69	11	these	these	DT
cord-018182-lleti89n	69	12	medications	medication	NNS
cord-018182-lleti89n	69	13	be	be	VB
cord-018182-lleti89n	69	14	administered	administer	VBN
cord-018182-lleti89n	69	15	in	in	IN
cord-018182-lleti89n	69	16	nebulized	nebulize	VBN
cord-018182-lleti89n	69	17	form	form	NN
cord-018182-lleti89n	69	18	as	as	IN
cord-018182-lleti89n	69	19	inhaler	inhaler	NN
cord-018182-lleti89n	69	20	use	use	NN
cord-018182-lleti89n	69	21	is	be	VBZ
cord-018182-lleti89n	69	22	difficult	difficult	JJ
cord-018182-lleti89n	69	23	for	for	IN
cord-018182-lleti89n	69	24	patients	patient	NNS
cord-018182-lleti89n	69	25	with	with	IN
cord-018182-lleti89n	69	26	significant	significant	JJ
cord-018182-lleti89n	69	27	respiratory	respiratory	JJ
cord-018182-lleti89n	69	28	distress	distress	NN
cord-018182-lleti89n	69	29	.	.	.
cord-018182-lleti89n	70	1	Metered	meter	VBN
cord-018182-lleti89n	70	2	-	-	HYPH
cord-018182-lleti89n	70	3	dose	dose	NN
cord-018182-lleti89n	70	4	inhalers	inhaler	NNS
cord-018182-lleti89n	70	5	should	should	MD
cord-018182-lleti89n	70	6	be	be	VB
cord-018182-lleti89n	70	7	used	use	VBN
cord-018182-lleti89n	70	8	for	for	IN
cord-018182-lleti89n	70	9	patients	patient	NNS
cord-018182-lleti89n	70	10	requiring	require	VBG
cord-018182-lleti89n	70	11	mechanical	mechanical	JJ
cord-018182-lleti89n	70	12	ventilation	ventilation	NN
cord-018182-lleti89n	70	13	.	.	.
cord-018182-lleti89n	71	1	As	as	IN
cord-018182-lleti89n	71	2	there	there	EX
cord-018182-lleti89n	71	3	is	be	VBZ
cord-018182-lleti89n	71	4	no	no	DT
cord-018182-lleti89n	71	5	evidence	evidence	NN
cord-018182-lleti89n	71	6	to	to	TO
cord-018182-lleti89n	71	7	support	support	VB
cord-018182-lleti89n	71	8	the	the	DT
cord-018182-lleti89n	71	9	addition	addition	NN
cord-018182-lleti89n	71	10	of	of	IN
cord-018182-lleti89n	71	11	methylxanthines	methylxanthine	NNS
cord-018182-lleti89n	71	12	during	during	IN
cord-018182-lleti89n	71	13	an	an	DT
cord-018182-lleti89n	71	14	exacerbation	exacerbation	NN
cord-018182-lleti89n	71	15	,	,	,
cord-018182-lleti89n	71	16	routine	routine	JJ
cord-018182-lleti89n	71	17	use	use	NN
cord-018182-lleti89n	71	18	is	be	VBZ
cord-018182-lleti89n	71	19	not	not	RB
cord-018182-lleti89n	71	20	recommended	recommend	VBN
cord-018182-lleti89n	71	21	[	[	-LRB-
cord-018182-lleti89n	71	22	8	8	CD
cord-018182-lleti89n	71	23	,	,	,
cord-018182-lleti89n	71	24	15	15	CD
cord-018182-lleti89n	71	25	]	]	-RRB-
cord-018182-lleti89n	71	26	.	.	.
cord-018182-lleti89n	72	1	Given	give	VBN
cord-018182-lleti89n	72	2	that	that	IN
cord-018182-lleti89n	72	3	the	the	DT
cord-018182-lleti89n	72	4	majority	majority	NN
cord-018182-lleti89n	72	5	of	of	IN
cord-018182-lleti89n	72	6	AECOPD	AECOPD	NNP
cord-018182-lleti89n	72	7	are	be	VBP
cord-018182-lleti89n	72	8	thought	think	VBN
cord-018182-lleti89n	72	9	to	to	TO
cord-018182-lleti89n	72	10	be	be	VB
cord-018182-lleti89n	72	11	due	due	JJ
cord-018182-lleti89n	72	12	to	to	IN
cord-018182-lleti89n	72	13	bacterial	bacterial	JJ
cord-018182-lleti89n	72	14	infections	infection	NNS
cord-018182-lleti89n	72	15	,	,	,
cord-018182-lleti89n	72	16	the	the	DT
cord-018182-lleti89n	72	17	empiric	empiric	JJ
cord-018182-lleti89n	72	18	administration	administration	NN
cord-018182-lleti89n	72	19	of	of	IN
cord-018182-lleti89n	72	20	antibiotics	antibiotic	NNS
cord-018182-lleti89n	72	21	in	in	IN
cord-018182-lleti89n	72	22	patients	patient	NNS
cord-018182-lleti89n	72	23	with	with	IN
cord-018182-lleti89n	72	24	COPD	COPD	NNP
cord-018182-lleti89n	72	25	exacerbations	exacerbation	NNS
cord-018182-lleti89n	72	26	has	have	VBZ
cord-018182-lleti89n	72	27	been	be	VBN
cord-018182-lleti89n	72	28	frequently	frequently	RB
cord-018182-lleti89n	72	29	studied	study	VBN
cord-018182-lleti89n	72	30	[	[	-LRB-
cord-018182-lleti89n	72	31	15	15	CD
cord-018182-lleti89n	72	32	]	]	-RRB-
cord-018182-lleti89n	72	33	.	.	.
cord-018182-lleti89n	73	1	Antibiotic	antibiotic	JJ
cord-018182-lleti89n	73	2	use	use	NN
cord-018182-lleti89n	73	3	during	during	IN
cord-018182-lleti89n	73	4	COPD	COPD	NNP
cord-018182-lleti89n	73	5	exacerbations	exacerbation	NNS
cord-018182-lleti89n	73	6	reduces	reduce	VBZ
cord-018182-lleti89n	73	7	treatment	treatment	NN
cord-018182-lleti89n	73	8	failures	failure	NNS
cord-018182-lleti89n	73	9	,	,	,
cord-018182-lleti89n	73	10	need	need	VBP
cord-018182-lleti89n	73	11	for	for	IN
cord-018182-lleti89n	73	12	mechanical	mechanical	JJ
cord-018182-lleti89n	73	13	ventilation	ventilation	NN
cord-018182-lleti89n	73	14	,	,	,
cord-018182-lleti89n	73	15	risk	risk	NN
cord-018182-lleti89n	73	16	for	for	IN
cord-018182-lleti89n	73	17	readmission	readmission	NN
cord-018182-lleti89n	73	18	,	,	,
cord-018182-lleti89n	73	19	as	as	RB
cord-018182-lleti89n	73	20	well	well	RB
cord-018182-lleti89n	73	21	as	as	IN
cord-018182-lleti89n	73	22	mortality	mortality	NN
cord-018182-lleti89n	73	23	when	when	WRB
cord-018182-lleti89n	73	24	administered	administer	VBN
cord-018182-lleti89n	73	25	in	in	IN
cord-018182-lleti89n	73	26	the	the	DT
cord-018182-lleti89n	73	27	inpatient	inpatient	NN
cord-018182-lleti89n	73	28	setting	set	VBG
cord-018182-lleti89n	73	29	[	[	-LRB-
cord-018182-lleti89n	73	30	16	16	CD
cord-018182-lleti89n	73	31	]	]	-RRB-
cord-018182-lleti89n	73	32	[	[	-LRB-
cord-018182-lleti89n	73	33	17	17	CD
cord-018182-lleti89n	73	34	]	]	-RRB-
cord-018182-lleti89n	73	35	[	[	-LRB-
cord-018182-lleti89n	73	36	18	18	CD
cord-018182-lleti89n	73	37	]	]	-RRB-
cord-018182-lleti89n	73	38	.	.	.
cord-018182-lleti89n	74	1	A	a	DT
cord-018182-lleti89n	74	2	study	study	NN
cord-018182-lleti89n	74	3	by	by	IN
cord-018182-lleti89n	74	4	Anthonisen	Anthonisen	NNP
cord-018182-lleti89n	74	5	et	et	NNP
cord-018182-lleti89n	74	6	al	al	NNP
cord-018182-lleti89n	74	7	.	.	NNP
cord-018182-lleti89n	74	8	showed	show	VBD
cord-018182-lleti89n	74	9	that	that	IN
cord-018182-lleti89n	74	10	patients	patient	NNS
cord-018182-lleti89n	74	11	with	with	IN
cord-018182-lleti89n	74	12	increases	increase	NNS
cord-018182-lleti89n	74	13	in	in	IN
cord-018182-lleti89n	74	14	sputum	sputum	NN
cord-018182-lleti89n	74	15	production	production	NN
cord-018182-lleti89n	74	16	or	or	CC
cord-018182-lleti89n	74	17	changes	change	NNS
cord-018182-lleti89n	74	18	in	in	IN
cord-018182-lleti89n	74	19	sputum	sputum	NN
cord-018182-lleti89n	74	20	color	color	NN
cord-018182-lleti89n	74	21	experienced	experience	VBD
cord-018182-lleti89n	74	22	a	a	DT
cord-018182-lleti89n	74	23	greater	great	JJR
cord-018182-lleti89n	74	24	benefit	benefit	NN
cord-018182-lleti89n	74	25	from	from	IN
cord-018182-lleti89n	74	26	antibiotics	antibiotic	NNS
cord-018182-lleti89n	74	27	[	[	-LRB-
cord-018182-lleti89n	74	28	19	19	CD
cord-018182-lleti89n	74	29	]	]	-RRB-
cord-018182-lleti89n	74	30	.	.	.
cord-018182-lleti89n	75	1	In	in	IN
cord-018182-lleti89n	75	2	addition	addition	NN
cord-018182-lleti89n	75	3	,	,	,
cord-018182-lleti89n	75	4	a	a	DT
cord-018182-lleti89n	75	5	study	study	NN
cord-018182-lleti89n	75	6	of	of	IN
cord-018182-lleti89n	75	7	patients	patient	NNS
cord-018182-lleti89n	75	8	with	with	IN
cord-018182-lleti89n	75	9	AECOPD	AECOPD	NNS
cord-018182-lleti89n	75	10	requiring	require	VBG
cord-018182-lleti89n	75	11	mechanical	mechanical	JJ
cord-018182-lleti89n	75	12	ventilation	ventilation	NN
cord-018182-lleti89n	75	13	showed	show	VBD
cord-018182-lleti89n	75	14	that	that	IN
cord-018182-lleti89n	75	15	administration	administration	NN
cord-018182-lleti89n	75	16	of	of	IN
cord-018182-lleti89n	75	17	a	a	DT
cord-018182-lleti89n	75	18	fluoroquinolone	fluoroquinolone	NN
cord-018182-lleti89n	75	19	reduced	reduce	VBN
cord-018182-lleti89n	75	20	mortality	mortality	NN
cord-018182-lleti89n	75	21	and	and	CC
cord-018182-lleti89n	75	22	the	the	DT
cord-018182-lleti89n	75	23	need	need	NN
cord-018182-lleti89n	75	24	for	for	IN
cord-018182-lleti89n	75	25	additional	additional	JJ
cord-018182-lleti89n	75	26	antibiotics	antibiotic	NNS
cord-018182-lleti89n	75	27	when	when	WRB
cord-018182-lleti89n	75	28	compared	compare	VBN
cord-018182-lleti89n	75	29	to	to	IN
cord-018182-lleti89n	75	30	placebo	placebo	NN
cord-018182-lleti89n	75	31	[	[	-LRB-
cord-018182-lleti89n	75	32	20	20	CD
cord-018182-lleti89n	75	33	]	]	-RRB-
cord-018182-lleti89n	75	34	.	.	.
cord-018182-lleti89n	76	1	Therefore	therefore	RB
cord-018182-lleti89n	76	2	,	,	,
cord-018182-lleti89n	76	3	antibiotics	antibiotic	NNS
cord-018182-lleti89n	76	4	are	be	VBP
cord-018182-lleti89n	76	5	recommended	recommend	VBN
cord-018182-lleti89n	76	6	for	for	IN
cord-018182-lleti89n	76	7	patients	patient	NNS
cord-018182-lleti89n	76	8	admitted	admit	VBN
cord-018182-lleti89n	76	9	to	to	IN
cord-018182-lleti89n	76	10	the	the	DT
cord-018182-lleti89n	76	11	ICU	ICU	NNP
cord-018182-lleti89n	76	12	,	,	,
cord-018182-lleti89n	76	13	particularly	particularly	RB
cord-018182-lleti89n	76	14	those	those	DT
cord-018182-lleti89n	76	15	requiring	require	VBG
cord-018182-lleti89n	76	16	mechanical	mechanical	JJ
cord-018182-lleti89n	76	17	ventilation	ventilation	NN
cord-018182-lleti89n	76	18	[	[	-LRB-
cord-018182-lleti89n	76	19	1	1	CD
cord-018182-lleti89n	76	20	,	,	,
cord-018182-lleti89n	76	21	8	8	CD
cord-018182-lleti89n	76	22	]	]	-RRB-
cord-018182-lleti89n	76	23	.	.	.
cord-018182-lleti89n	77	1	In	in	IN
cord-018182-lleti89n	77	2	uncomplicated	uncomplicated	JJ
cord-018182-lleti89n	77	3	patients	patient	NNS
cord-018182-lleti89n	77	4	,	,	,
cord-018182-lleti89n	77	5	a	a	DT
cord-018182-lleti89n	77	6	beta	beta	NN
cord-018182-lleti89n	77	7	-	-	HYPH
cord-018182-lleti89n	77	8	lactam	lactam	NN
cord-018182-lleti89n	77	9	,	,	,
cord-018182-lleti89n	77	10	macrolide	macrolide	NN
cord-018182-lleti89n	77	11	,	,	,
cord-018182-lleti89n	77	12	or	or	CC
cord-018182-lleti89n	77	13	tetracycline	tetracycline	NN
cord-018182-lleti89n	77	14	antibiotic	antibiotic	NN
cord-018182-lleti89n	77	15	may	may	MD
cord-018182-lleti89n	77	16	be	be	VB
cord-018182-lleti89n	77	17	used	use	VBN
cord-018182-lleti89n	77	18	[	[	-LRB-
cord-018182-lleti89n	77	19	8	8	CD
cord-018182-lleti89n	77	20	]	]	-RRB-
cord-018182-lleti89n	77	21	.	.	.
cord-018182-lleti89n	78	1	For	for	IN
cord-018182-lleti89n	78	2	most	most	JJS
cord-018182-lleti89n	78	3	ICU	ICU	NNP
cord-018182-lleti89n	78	4	patients	patient	NNS
cord-018182-lleti89n	78	5	,	,	,
cord-018182-lleti89n	78	6	we	-PRON-	PRP
cord-018182-lleti89n	78	7	recommend	recommend	VBP
cord-018182-lleti89n	78	8	a	a	DT
cord-018182-lleti89n	78	9	respiratory	respiratory	JJ
cord-018182-lleti89n	78	10	fluoroquinolone	fluoroquinolone	NN
cord-018182-lleti89n	78	11	,	,	,
cord-018182-lleti89n	78	12	third	third	JJ
cord-018182-lleti89n	78	13	-	-	HYPH
cord-018182-lleti89n	78	14	or	or	CC
cord-018182-lleti89n	78	15	fourth	fourth	JJ
cord-018182-lleti89n	78	16	-	-	HYPH
cord-018182-lleti89n	78	17	generation	generation	NN
cord-018182-lleti89n	78	18	cephalosporin	cephalosporin	NN
cord-018182-lleti89n	78	19	,	,	,
cord-018182-lleti89n	78	20	or	or	CC
cord-018182-lleti89n	78	21	piperacillin	piperacillin	NNP
cord-018182-lleti89n	78	22	/	/	SYM
cord-018182-lleti89n	78	23	tazobactam	tazobactam	NNS
cord-018182-lleti89n	78	24	.	.	.
cord-018182-lleti89n	79	1	Coverage	coverage	NN
cord-018182-lleti89n	79	2	for	for	IN
cord-018182-lleti89n	79	3	atypical	atypical	JJ
cord-018182-lleti89n	79	4	bacteria	bacteria	NNS
cord-018182-lleti89n	79	5	with	with	IN
cord-018182-lleti89n	79	6	a	a	DT
cord-018182-lleti89n	79	7	macrolide	macrolide	NN
cord-018182-lleti89n	79	8	or	or	CC
cord-018182-lleti89n	79	9	fluoroquinolone	fluoroquinolone	NN
cord-018182-lleti89n	79	10	is	be	VBZ
cord-018182-lleti89n	79	11	also	also	RB
cord-018182-lleti89n	79	12	recommended	recommend	VBN
cord-018182-lleti89n	79	13	if	if	IN
cord-018182-lleti89n	79	14	the	the	DT
cord-018182-lleti89n	79	15	patient	patient	NN
cord-018182-lleti89n	79	16	lives	live	VBZ
cord-018182-lleti89n	79	17	in	in	IN
cord-018182-lleti89n	79	18	the	the	DT
cord-018182-lleti89n	79	19	community	community	NN
cord-018182-lleti89n	79	20	.	.	.
cord-018182-lleti89n	80	1	Broader	broad	JJR
cord-018182-lleti89n	80	2	coverage	coverage	NN
cord-018182-lleti89n	80	3	for	for	IN
cord-018182-lleti89n	80	4	nosocomial	nosocomial	JJ
cord-018182-lleti89n	80	5	pathogens	pathogen	NNS
cord-018182-lleti89n	80	6	is	be	VBZ
cord-018182-lleti89n	80	7	recommended	recommend	VBN
cord-018182-lleti89n	80	8	for	for	IN
cord-018182-lleti89n	80	9	patients	patient	NNS
cord-018182-lleti89n	80	10	residing	reside	VBG
cord-018182-lleti89n	80	11	in	in	IN
cord-018182-lleti89n	80	12	health	health	NN
cord-018182-lleti89n	80	13	-	-	HYPH
cord-018182-lleti89n	80	14	care	care	NN
cord-018182-lleti89n	80	15	settings	setting	NNS
cord-018182-lleti89n	80	16	and	and	CC
cord-018182-lleti89n	80	17	those	those	DT
cord-018182-lleti89n	80	18	who	who	WP
cord-018182-lleti89n	80	19	have	have	VBP
cord-018182-lleti89n	80	20	had	have	VBN
cord-018182-lleti89n	80	21	recent	recent	JJ
cord-018182-lleti89n	80	22	or	or	CC
cord-018182-lleti89n	80	23	repetitive	repetitive	JJ
cord-018182-lleti89n	80	24	contact	contact	NN
cord-018182-lleti89n	80	25	with	with	IN
cord-018182-lleti89n	80	26	the	the	DT
cord-018182-lleti89n	80	27	hospital	hospital	NN
cord-018182-lleti89n	80	28	environment	environment	NN
cord-018182-lleti89n	80	29	or	or	CC
cord-018182-lleti89n	80	30	therapeutic	therapeutic	JJ
cord-018182-lleti89n	80	31	courses	course	NNS
cord-018182-lleti89n	80	32	of	of	IN
cord-018182-lleti89n	80	33	antimicrobial	antimicrobial	JJ
cord-018182-lleti89n	80	34	agents	agent	NNS
cord-018182-lleti89n	80	35	.	.	.
cord-018182-lleti89n	81	1	Combination	combination	NN
cord-018182-lleti89n	81	2	therapy	therapy	NN
cord-018182-lleti89n	81	3	is	be	VBZ
cord-018182-lleti89n	81	4	often	often	RB
cord-018182-lleti89n	81	5	necessary	necessary	JJ
cord-018182-lleti89n	81	6	[	[	-LRB-
cord-018182-lleti89n	81	7	1	1	CD
cord-018182-lleti89n	81	8	,	,	,
cord-018182-lleti89n	81	9	14	14	CD
cord-018182-lleti89n	81	10	,	,	,
cord-018182-lleti89n	81	11	15	15	CD
cord-018182-lleti89n	81	12	]	]	-RRB-
cord-018182-lleti89n	81	13	.	.	.
cord-018182-lleti89n	82	1	See	see	VB
cord-018182-lleti89n	82	2	Table	table	NN
cord-018182-lleti89n	82	3	13	13	CD
cord-018182-lleti89n	82	4	.3	.3	CD
cord-018182-lleti89n	82	5	for	for	IN
cord-018182-lleti89n	82	6	antibiotic	antibiotic	JJ
cord-018182-lleti89n	82	7	recommendations	recommendation	NNS
cord-018182-lleti89n	82	8	.	.	.
cord-018182-lleti89n	83	1	In	in	IN
cord-018182-lleti89n	83	2	general	general	JJ
cord-018182-lleti89n	83	3	,	,	,
cord-018182-lleti89n	83	4	a	a	DT
cord-018182-lleti89n	83	5	total	total	JJ
cord-018182-lleti89n	83	6	duration	duration	NN
cord-018182-lleti89n	83	7	of	of	IN
cord-018182-lleti89n	83	8	7	7	CD
cord-018182-lleti89n	83	9	days	day	NNS
cord-018182-lleti89n	83	10	of	of	IN
cord-018182-lleti89n	83	11	antibiotics	antibiotic	NNS
cord-018182-lleti89n	83	12	is	be	VBZ
cord-018182-lleti89n	83	13	usually	usually	RB
cord-018182-lleti89n	83	14	appropriate	appropriate	JJ
cord-018182-lleti89n	83	15	.	.	.
cord-018182-lleti89n	84	1	Coverage	coverage	NN
cord-018182-lleti89n	84	2	may	may	MD
cord-018182-lleti89n	84	3	be	be	VB
cord-018182-lleti89n	84	4	tailored	tailor	VBN
cord-018182-lleti89n	84	5	based	base	VBN
cord-018182-lleti89n	84	6	on	on	IN
cord-018182-lleti89n	84	7	sputum	sputum	NN
cord-018182-lleti89n	84	8	culture	culture	NN
cord-018182-lleti89n	84	9	results	result	NNS
cord-018182-lleti89n	84	10	and	and	CC
cord-018182-lleti89n	84	11	sensitivities	sensitivity	NNS
cord-018182-lleti89n	84	12	.	.	.
cord-018182-lleti89n	85	1	There	there	EX
cord-018182-lleti89n	85	2	is	be	VBZ
cord-018182-lleti89n	85	3	no	no	DT
cord-018182-lleti89n	85	4	data	data	NN
cord-018182-lleti89n	85	5	to	to	TO
cord-018182-lleti89n	85	6	support	support	VB
cord-018182-lleti89n	85	7	the	the	DT
cord-018182-lleti89n	85	8	routine	routine	JJ
cord-018182-lleti89n	85	9	use	use	NN
cord-018182-lleti89n	85	10	of	of	IN
cord-018182-lleti89n	85	11	pharmacologic	pharmacologic	JJ
cord-018182-lleti89n	85	12	adjuncts	adjunct	NNS
cord-018182-lleti89n	85	13	or	or	CC
cord-018182-lleti89n	85	14	bronchoscopic	bronchoscopic	JJ
cord-018182-lleti89n	85	15	mucus	mucus	NN
cord-018182-lleti89n	85	16	clearance	clearance	NN
cord-018182-lleti89n	85	17	techniques	technique	NNS
cord-018182-lleti89n	85	18	,	,	,
cord-018182-lleti89n	85	19	although	although	IN
cord-018182-lleti89n	85	20	efforts	effort	NNS
cord-018182-lleti89n	85	21	to	to	TO
cord-018182-lleti89n	85	22	clear	clear	VB
cord-018182-lleti89n	85	23	secretions	secretion	NNS
cord-018182-lleti89n	85	24	via	via	IN
cord-018182-lleti89n	85	25	pulmonary	pulmonary	JJ
cord-018182-lleti89n	85	26	toiletry	toiletry	NN
cord-018182-lleti89n	85	27	and	and	CC
cord-018182-lleti89n	85	28	chest	chest	NN
cord-018182-lleti89n	85	29	physiotherapy	physiotherapy	NN
cord-018182-lleti89n	85	30	(	(	-LRB-
cord-018182-lleti89n	85	31	e.g.	e.g.	RB
cord-018182-lleti89n	85	32	,	,	,
cord-018182-lleti89n	85	33	percussion	percussion	NN
cord-018182-lleti89n	85	34	and	and	CC
cord-018182-lleti89n	85	35	postural	postural	JJ
cord-018182-lleti89n	85	36	drainage	drainage	NN
cord-018182-lleti89n	85	37	)	)	-RRB-
cord-018182-lleti89n	85	38	are	be	VBP
cord-018182-lleti89n	85	39	reasonable	reasonable	JJ
cord-018182-lleti89n	85	40	[	[	-LRB-
cord-018182-lleti89n	85	41	15	15	CD
cord-018182-lleti89n	85	42	]	]	-RRB-
cord-018182-lleti89n	85	43	.	.	.
cord-018182-lleti89n	86	1	Oxygen	oxygen	NN
cord-018182-lleti89n	86	2	supplementation	supplementation	NN
cord-018182-lleti89n	86	3	is	be	VBZ
cord-018182-lleti89n	86	4	frequently	frequently	RB
cord-018182-lleti89n	86	5	necessary	necessary	JJ
cord-018182-lleti89n	86	6	in	in	IN
cord-018182-lleti89n	86	7	AECOPD	AECOPD	NNP
cord-018182-lleti89n	86	8	.	.	.
cord-018182-lleti89n	87	1	In	in	IN
cord-018182-lleti89n	87	2	order	order	NN
cord-018182-lleti89n	87	3	to	to	TO
cord-018182-lleti89n	87	4	maintain	maintain	VB
cord-018182-lleti89n	87	5	adequate	adequate	JJ
cord-018182-lleti89n	87	6	cellular	cellular	JJ
cord-018182-lleti89n	87	7	oxygenation	oxygenation	NN
cord-018182-lleti89n	87	8	while	while	IN
cord-018182-lleti89n	87	9	avoiding	avoid	VBG
cord-018182-lleti89n	87	10	hypercapnia	hypercapnia	NN
cord-018182-lleti89n	87	11	,	,	,
cord-018182-lleti89n	87	12	careful	careful	JJ
cord-018182-lleti89n	87	13	monitoring	monitoring	NN
cord-018182-lleti89n	87	14	and	and	CC
cord-018182-lleti89n	87	15	avoidance	avoidance	NN
cord-018182-lleti89n	87	16	of	of	IN
cord-018182-lleti89n	87	17	over	over	IN
cord-018182-lleti89n	87	18	-	-	HYPH
cord-018182-lleti89n	87	19	supplementation	supplementation	NN
cord-018182-lleti89n	87	20	is	be	VBZ
cord-018182-lleti89n	87	21	prudent	prudent	JJ
cord-018182-lleti89n	87	22	.	.	.
cord-018182-lleti89n	88	1	The	the	DT
cord-018182-lleti89n	88	2	goal	goal	NN
cord-018182-lleti89n	88	3	is	be	VBZ
cord-018182-lleti89n	88	4	to	to	TO
cord-018182-lleti89n	88	5	maintain	maintain	VB
cord-018182-lleti89n	88	6	a	a	DT
cord-018182-lleti89n	88	7	PaO	pao	JJ
cord-018182-lleti89n	88	8	2	2	CD
cord-018182-lleti89n	88	9	>	>	SYM
cord-018182-lleti89n	88	10	60	60	CD
cord-018182-lleti89n	88	11	mmHg	mmHg	NNS
cord-018182-lleti89n	88	12	or	or	CC
cord-018182-lleti89n	88	13	SpO	spo	JJ
cord-018182-lleti89n	88	14	2	2	CD
cord-018182-lleti89n	88	15	of	of	IN
cord-018182-lleti89n	88	16	88	88	CD
cord-018182-lleti89n	88	17	-	-	SYM
cord-018182-lleti89n	88	18	92	92	CD
cord-018182-lleti89n	88	19	%	%	NN
cord-018182-lleti89n	88	20	.	.	.
cord-018182-lleti89n	89	1	Values	value	NNS
cord-018182-lleti89n	89	2	significantly	significantly	RB
cord-018182-lleti89n	89	3	above	above	IN
cord-018182-lleti89n	89	4	this	this	DT
cord-018182-lleti89n	89	5	provide	provide	VBP
cord-018182-lleti89n	89	6	little	little	JJ
cord-018182-lleti89n	89	7	added	add	VBN
cord-018182-lleti89n	89	8	benefit	benefit	NN
cord-018182-lleti89n	89	9	while	while	IN
cord-018182-lleti89n	89	10	potentially	potentially	RB
cord-018182-lleti89n	89	11	promoting	promote	VBG
cord-018182-lleti89n	89	12	CO	CO	NNP
cord-018182-lleti89n	89	13	2	2	CD
cord-018182-lleti89n	89	14	retention	retention	NN
cord-018182-lleti89n	89	15	in	in	IN
cord-018182-lleti89n	89	16	this	this	DT
cord-018182-lleti89n	89	17	at	at	IN
cord-018182-lleti89n	89	18	-	-	HYPH
cord-018182-lleti89n	89	19	risk	risk	NN
cord-018182-lleti89n	89	20	population	population	NN
cord-018182-lleti89n	89	21	.	.	.
cord-018182-lleti89n	90	1	ABGs	ABGs	NNP
cord-018182-lleti89n	90	2	should	should	MD
cord-018182-lleti89n	90	3	be	be	VB
cord-018182-lleti89n	90	4	checked	check	VBN
cord-018182-lleti89n	90	5	frequently	frequently	RB
cord-018182-lleti89n	90	6	to	to	TO
cord-018182-lleti89n	90	7	identify	identify	VB
cord-018182-lleti89n	90	8	any	any	DT
cord-018182-lleti89n	90	9	potential	potential	JJ
cord-018182-lleti89n	90	10	interval	interval	NN
cord-018182-lleti89n	90	11	worsening	worsen	VBG
cord-018182-lleti89n	90	12	of	of	IN
cord-018182-lleti89n	90	13	respiratory	respiratory	JJ
cord-018182-lleti89n	90	14	acidosis	acidosis	NN
cord-018182-lleti89n	90	15	;	;	:
cord-018182-lleti89n	90	16	VBGs	VBGs	NNP
cord-018182-lleti89n	90	17	may	may	MD
cord-018182-lleti89n	90	18	be	be	VB
cord-018182-lleti89n	90	19	a	a	DT
cord-018182-lleti89n	90	20	reasonable	reasonable	JJ
cord-018182-lleti89n	90	21	alternative	alternative	NN
cord-018182-lleti89n	90	22	to	to	IN
cord-018182-lleti89n	90	23	ABG	ABG	NNP
cord-018182-lleti89n	90	24	analysis	analysis	NN
cord-018182-lleti89n	90	25	when	when	WRB
cord-018182-lleti89n	90	26	the	the	DT
cord-018182-lleti89n	90	27	focus	focus	NN
cord-018182-lleti89n	90	28	of	of	IN
cord-018182-lleti89n	90	29	inquiry	inquiry	NN
cord-018182-lleti89n	90	30	is	be	VBZ
cord-018182-lleti89n	90	31	pH	ph	NN
cord-018182-lleti89n	90	32	-	-	:
cord-018182-lleti89n	90	33	pCO	pco	JJ
cord-018182-lleti89n	90	34	2	2	CD
cord-018182-lleti89n	90	35	balance	balance	NN
cord-018182-lleti89n	90	36	as	as	IN
cord-018182-lleti89n	90	37	opposed	oppose	VBN
cord-018182-lleti89n	90	38	to	to	IN
cord-018182-lleti89n	90	39	oxygenation	oxygenation	NN
cord-018182-lleti89n	90	40	[	[	-LRB-
cord-018182-lleti89n	90	41	1	1	CD
cord-018182-lleti89n	90	42	]	]	-RRB-
cord-018182-lleti89n	90	43	.	.	.
cord-018182-lleti89n	91	1	Many	many	JJ
cord-018182-lleti89n	91	2	patients	patient	NNS
cord-018182-lleti89n	91	3	with	with	IN
cord-018182-lleti89n	91	4	AECOPD	AECOPD	NNP
cord-018182-lleti89n	91	5	will	will	MD
cord-018182-lleti89n	91	6	require	require	VB
cord-018182-lleti89n	91	7	respiratory	respiratory	JJ
cord-018182-lleti89n	91	8	support	support	NN
cord-018182-lleti89n	91	9	beyond	beyond	IN
cord-018182-lleti89n	91	10	supplemental	supplemental	JJ
cord-018182-lleti89n	91	11	oxygen	oxygen	NN
cord-018182-lleti89n	91	12	.	.	.
cord-018182-lleti89n	92	1	Although	although	IN
cord-018182-lleti89n	92	2	endotracheal	endotracheal	JJ
cord-018182-lleti89n	92	3	intubation	intubation	NN
cord-018182-lleti89n	92	4	may	may	MD
cord-018182-lleti89n	92	5	be	be	VB
cord-018182-lleti89n	92	6	required	require	VBN
cord-018182-lleti89n	92	7	in	in	IN
cord-018182-lleti89n	92	8	severe	severe	JJ
cord-018182-lleti89n	92	9	cases	case	NNS
cord-018182-lleti89n	92	10	,	,	,
cord-018182-lleti89n	92	11	noninvasive	noninvasive	JJ
cord-018182-lleti89n	92	12	positive	positive	JJ
cord-018182-lleti89n	92	13	-	-	HYPH
cord-018182-lleti89n	92	14	pressure	pressure	NN
cord-018182-lleti89n	92	15	ventilation	ventilation	NN
cord-018182-lleti89n	92	16	(	(	-LRB-
cord-018182-lleti89n	92	17	NPPV	NPPV	NNP
cord-018182-lleti89n	92	18	)	)	-RRB-
cord-018182-lleti89n	92	19	is	be	VBZ
cord-018182-lleti89n	92	20	a	a	DT
cord-018182-lleti89n	92	21	first	first	JJ
cord-018182-lleti89n	92	22	choice	choice	NN
cord-018182-lleti89n	92	23	treatment	treatment	NN
cord-018182-lleti89n	92	24	for	for	IN
cord-018182-lleti89n	92	25	patients	patient	NNS
cord-018182-lleti89n	92	26	with	with	IN
cord-018182-lleti89n	92	27	hypercapnic	hypercapnic	NNP
cord-018182-lleti89n	92	28	respiratory	respiratory	JJ
cord-018182-lleti89n	92	29	failure	failure	NN
cord-018182-lleti89n	92	30	in	in	IN
cord-018182-lleti89n	92	31	severe	severe	JJ
cord-018182-lleti89n	92	32	AECOPD	aecopd	NN
cord-018182-lleti89n	92	33	and	and	CC
cord-018182-lleti89n	93	1	when	when	WRB
cord-018182-lleti89n	93	2	there	there	EX
cord-018182-lleti89n	93	3	are	be	VBP
cord-018182-lleti89n	93	4	no	no	DT
cord-018182-lleti89n	93	5	contraindications	contraindication	NNS
cord-018182-lleti89n	93	6	to	to	IN
cord-018182-lleti89n	93	7	noninvasive	noninvasive	JJ
cord-018182-lleti89n	93	8	ventilation	ventilation	NN
cord-018182-lleti89n	93	9	(	(	-LRB-
cord-018182-lleti89n	93	10	see	see	VB
cord-018182-lleti89n	93	11	Table	Table	NNP
cord-018182-lleti89n	93	12	13	13	CD
cord-018182-lleti89n	93	13	.4	.4	CD
cord-018182-lleti89n	93	14	)	)	-RRB-
cord-018182-lleti89n	93	15	.	.	.
cord-018182-lleti89n	94	1	Patients	patient	NNS
cord-018182-lleti89n	94	2	with	with	IN
cord-018182-lleti89n	94	3	clinical	clinical	JJ
cord-018182-lleti89n	94	4	signs	sign	NNS
cord-018182-lleti89n	94	5	of	of	IN
cord-018182-lleti89n	94	6	respiratory	respiratory	JJ
cord-018182-lleti89n	94	7	muscle	muscle	NN
cord-018182-lleti89n	94	8	fatigue	fatigue	NN
cord-018182-lleti89n	94	9	and/or	and/or	CC
cord-018182-lleti89n	94	10	increased	increased	JJ
cord-018182-lleti89n	94	11	work	work	NN
cord-018182-lleti89n	94	12	of	of	IN
cord-018182-lleti89n	94	13	breathing	breathing	NN
cord-018182-lleti89n	94	14	should	should	MD
cord-018182-lleti89n	94	15	also	also	RB
cord-018182-lleti89n	94	16	be	be	VB
cord-018182-lleti89n	94	17	considered	consider	VBN
cord-018182-lleti89n	94	18	for	for	IN
cord-018182-lleti89n	94	19	early	early	JJ
cord-018182-lleti89n	94	20	NPPV	NPPV	NNP
cord-018182-lleti89n	94	21	initiation	initiation	NN
cord-018182-lleti89n	94	22	.	.	.
cord-018182-lleti89n	95	1	The	the	DT
cord-018182-lleti89n	95	2	success	success	NN
cord-018182-lleti89n	95	3	rate	rate	NN
cord-018182-lleti89n	95	4	of	of	IN
cord-018182-lleti89n	95	5	NPPV	NPPV	NNP
cord-018182-lleti89n	95	6	in	in	IN
cord-018182-lleti89n	95	7	randomized	randomized	JJ
cord-018182-lleti89n	95	8	controlled	control	VBN
cord-018182-lleti89n	95	9	trials	trial	NNS
cord-018182-lleti89n	95	10	of	of	IN
cord-018182-lleti89n	95	11	patients	patient	NNS
cord-018182-lleti89n	95	12	with	with	IN
cord-018182-lleti89n	95	13	severe	severe	JJ
cord-018182-lleti89n	95	14	AECOPD	AECOPD	NNP
cord-018182-lleti89n	95	15	has	have	VBZ
cord-018182-lleti89n	95	16	been	be	VBN
cord-018182-lleti89n	95	17	documented	document	VBN
cord-018182-lleti89n	95	18	as	as	IN
cord-018182-lleti89n	95	19	80	80	CD
cord-018182-lleti89n	95	20	-	-	SYM
cord-018182-lleti89n	95	21	85	85	CD
cord-018182-lleti89n	95	22	%	%	NN
cord-018182-lleti89n	95	23	,	,	,
cord-018182-lleti89n	95	24	with	with	IN
cord-018182-lleti89n	95	25	improvements	improvement	NNS
cord-018182-lleti89n	95	26	in	in	IN
cord-018182-lleti89n	95	27	acute	acute	JJ
cord-018182-lleti89n	95	28	respiratory	respiratory	JJ
cord-018182-lleti89n	95	29	acidosis	acidosis	NN
cord-018182-lleti89n	95	30	,	,	,
cord-018182-lleti89n	95	31	tachypnea	tachypnea	NN
cord-018182-lleti89n	95	32	,	,	,
cord-018182-lleti89n	95	33	work	work	NN
cord-018182-lleti89n	95	34	of	of	IN
cord-018182-lleti89n	95	35	breathing	breathing	NN
cord-018182-lleti89n	95	36	,	,	,
cord-018182-lleti89n	95	37	and	and	CC
cord-018182-lleti89n	95	38	decreases	decrease	VBZ
cord-018182-lleti89n	95	39	in	in	IN
cord-018182-lleti89n	95	40	ventilatorassociated	ventilatorassociate	VBN
cord-018182-lleti89n	95	41	events	event	NNS
cord-018182-lleti89n	95	42	[	[	-LRB-
cord-018182-lleti89n	95	43	8	8	CD
cord-018182-lleti89n	95	44	,	,	,
cord-018182-lleti89n	95	45	21	21	CD
cord-018182-lleti89n	95	46	]	]	-RRB-
cord-018182-lleti89n	95	47	.	.	.
cord-018182-lleti89n	96	1	Previous	previous	JJ
cord-018182-lleti89n	96	2	studies	study	NNS
cord-018182-lleti89n	96	3	demonstrated	demonstrate	VBD
cord-018182-lleti89n	96	4	that	that	IN
cord-018182-lleti89n	96	5	the	the	DT
cord-018182-lleti89n	96	6	use	use	NN
cord-018182-lleti89n	96	7	of	of	IN
cord-018182-lleti89n	96	8	NPPV	NPPV	NNP
cord-018182-lleti89n	96	9	was	be	VBD
cord-018182-lleti89n	96	10	associated	associate	VBN
cord-018182-lleti89n	96	11	with	with	IN
cord-018182-lleti89n	96	12	a	a	DT
cord-018182-lleti89n	96	13	reduction	reduction	NN
cord-018182-lleti89n	96	14	in	in	IN
cord-018182-lleti89n	96	15	the	the	DT
cord-018182-lleti89n	96	16	overall	overall	JJ
cord-018182-lleti89n	96	17	need	need	NN
cord-018182-lleti89n	96	18	for	for	IN
cord-018182-lleti89n	96	19	endotracheal	endotracheal	JJ
cord-018182-lleti89n	96	20	intubation	intubation	NN
cord-018182-lleti89n	96	21	,	,	,
cord-018182-lleti89n	96	22	lower	low	JJR
cord-018182-lleti89n	96	23	cost	cost	NN
cord-018182-lleti89n	96	24	,	,	,
cord-018182-lleti89n	96	25	reduced	reduce	VBN
cord-018182-lleti89n	96	26	ICU	ICU	NNP
cord-018182-lleti89n	96	27	length	length	NN
cord-018182-lleti89n	96	28	of	of	IN
cord-018182-lleti89n	96	29	stay	stay	NN
cord-018182-lleti89n	96	30	,	,	,
cord-018182-lleti89n	96	31	and	and	CC
cord-018182-lleti89n	96	32	decreased	decrease	VBD
cord-018182-lleti89n	96	33	overall	overall	JJ
cord-018182-lleti89n	96	34	ICU	ICU	NNP
cord-018182-lleti89n	96	35	mortality	mortality	NN
cord-018182-lleti89n	96	36	for	for	IN
cord-018182-lleti89n	96	37	patients	patient	NNS
cord-018182-lleti89n	96	38	placed	place	VBN
cord-018182-lleti89n	96	39	on	on	IN
cord-018182-lleti89n	96	40	NPPV	NPPV	NNP
cord-018182-lleti89n	96	41	[	[	-LRB-
cord-018182-lleti89n	96	42	22	22	CD
cord-018182-lleti89n	96	43	,	,	,
cord-018182-lleti89n	96	44	23	23	CD
cord-018182-lleti89n	96	45	]	]	-RRB-
cord-018182-lleti89n	96	46	.	.	.
cord-018182-lleti89n	97	1	NPPV	NPPV	NNP
cord-018182-lleti89n	97	2	may	may	MD
cord-018182-lleti89n	97	3	not	not	RB
cord-018182-lleti89n	97	4	be	be	VB
cord-018182-lleti89n	97	5	efficacious	efficacious	JJ
cord-018182-lleti89n	97	6	in	in	IN
cord-018182-lleti89n	97	7	all	all	DT
cord-018182-lleti89n	97	8	patients	patient	NNS
cord-018182-lleti89n	97	9	with	with	IN
cord-018182-lleti89n	97	10	AECOPD	AECOPD	NNP
cord-018182-lleti89n	97	11	.	.	.
cord-018182-lleti89n	98	1	In	in	IN
cord-018182-lleti89n	98	2	particular	particular	JJ
cord-018182-lleti89n	98	3	,	,	,
cord-018182-lleti89n	98	4	patients	patient	NNS
cord-018182-lleti89n	98	5	with	with	IN
cord-018182-lleti89n	98	6	Glasgow	Glasgow	NNP
cord-018182-lleti89n	98	7	Coma	Coma	NNP
cord-018182-lleti89n	98	8	Scale	Scale	NNP
cord-018182-lleti89n	98	9	score	score	VBD
cord-018182-lleti89n	98	10	<	<	XX
cord-018182-lleti89n	98	11	11	11	CD
cord-018182-lleti89n	98	12	,	,	,
cord-018182-lleti89n	98	13	acute	acute	JJ
cord-018182-lleti89n	98	14	physiology	physiology	NN
cord-018182-lleti89n	98	15	and	and	CC
cord-018182-lleti89n	98	16	chronic	chronic	JJ
cord-018182-lleti89n	98	17	health	health	NN
cord-018182-lleti89n	98	18	evaluation	evaluation	NN
cord-018182-lleti89n	98	19	(	(	-LRB-
cord-018182-lleti89n	98	20	APACHE	APACHE	NNP
cord-018182-lleti89n	98	21	)	)	-RRB-
cord-018182-lleti89n	98	22	score	score	NN
cord-018182-lleti89n	98	23	≥29	≥29	RB
cord-018182-lleti89n	98	24	,	,	,
cord-018182-lleti89n	98	25	respiratory	respiratory	JJ
cord-018182-lleti89n	98	26	rate	rate	NN
cord-018182-lleti89n	98	27	≥30	≥30	NNS
cord-018182-lleti89n	98	28	,	,	,
cord-018182-lleti89n	98	29	and	and	CC
cord-018182-lleti89n	98	30	admission	admission	NN
cord-018182-lleti89n	98	31	pH	pH	NNP
cord-018182-lleti89n	98	32	<	<	XX
cord-018182-lleti89n	98	33	7.25	7.25	CD
cord-018182-lleti89n	98	34	have	have	VBP
cord-018182-lleti89n	98	35	a	a	DT
cord-018182-lleti89n	98	36	failure	failure	NN
cord-018182-lleti89n	98	37	rate	rate	NN
cord-018182-lleti89n	98	38	of	of	IN
cord-018182-lleti89n	98	39	that	that	WDT
cord-018182-lleti89n	98	40	exceeds	exceed	VBZ
cord-018182-lleti89n	98	41	70	70	CD
cord-018182-lleti89n	98	42	%	%	NN
cord-018182-lleti89n	98	43	.	.	.
cord-018182-lleti89n	99	1	Close	close	JJ
cord-018182-lleti89n	99	2	monitoring	monitoring	NN
cord-018182-lleti89n	99	3	while	while	IN
cord-018182-lleti89n	99	4	on	on	IN
cord-018182-lleti89n	99	5	NPPV	NPPV	NNP
cord-018182-lleti89n	99	6	is	be	VBZ
cord-018182-lleti89n	99	7	necessary	necessary	JJ
cord-018182-lleti89n	99	8	and	and	CC
cord-018182-lleti89n	99	9	rapid	rapid	JJ
cord-018182-lleti89n	99	10	clinical	clinical	JJ
cord-018182-lleti89n	99	11	improvement	improvement	NN
cord-018182-lleti89n	99	12	is	be	VBZ
cord-018182-lleti89n	99	13	expected	expect	VBN
cord-018182-lleti89n	99	14	if	if	IN
cord-018182-lleti89n	99	15	NPPV	NPPV	NNP
cord-018182-lleti89n	99	16	is	be	VBZ
cord-018182-lleti89n	99	17	likely	likely	JJ
cord-018182-lleti89n	99	18	to	to	TO
cord-018182-lleti89n	99	19	be	be	VB
cord-018182-lleti89n	99	20	of	of	IN
cord-018182-lleti89n	99	21	benefit	benefit	NN
cord-018182-lleti89n	99	22	.	.	.
cord-018182-lleti89n	100	1	Studies	study	NNS
cord-018182-lleti89n	100	2	have	have	VBP
cord-018182-lleti89n	100	3	shown	show	VBN
cord-018182-lleti89n	100	4	that	that	IN
cord-018182-lleti89n	100	5	if	if	IN
cord-018182-lleti89n	100	6	the	the	DT
cord-018182-lleti89n	100	7	pH	pH	NNP
cord-018182-lleti89n	100	8	after	after	IN
cord-018182-lleti89n	100	9	2	2	CD
cord-018182-lleti89n	100	10	h	h	NN
cord-018182-lleti89n	100	11	of	of	IN
cord-018182-lleti89n	100	12	NPPV	NPPV	NNP
cord-018182-lleti89n	100	13	remains	remain	VBZ
cord-018182-lleti89n	100	14	<	<	NNP
cord-018182-lleti89n	100	15	7.25	7.25	CD
cord-018182-lleti89n	100	16	,	,	,
cord-018182-lleti89n	100	17	there	there	EX
cord-018182-lleti89n	100	18	is	be	VBZ
cord-018182-lleti89n	100	19	a	a	DT
cord-018182-lleti89n	100	20	high	high	JJ
cord-018182-lleti89n	100	21	likelihood	likelihood	NN
cord-018182-lleti89n	100	22	of	of	IN
cord-018182-lleti89n	100	23	failure	failure	NN
cord-018182-lleti89n	100	24	(	(	-LRB-
cord-018182-lleti89n	100	25	70	70	CD
cord-018182-lleti89n	100	26	-	-	SYM
cord-018182-lleti89n	100	27	90	90	CD
cord-018182-lleti89n	100	28	%	%	NN
cord-018182-lleti89n	100	29	)	)	-RRB-
cord-018182-lleti89n	100	30	,	,	,
cord-018182-lleti89n	100	31	and	and	CC
cord-018182-lleti89n	100	32	endotracheal	endotracheal	JJ
cord-018182-lleti89n	100	33	intubation	intubation	NN
cord-018182-lleti89n	100	34	should	should	MD
cord-018182-lleti89n	100	35	be	be	VB
cord-018182-lleti89n	100	36	considered	consider	VBN
cord-018182-lleti89n	100	37	.	.	.
cord-018182-lleti89n	101	1	Conversely	conversely	RB
cord-018182-lleti89n	101	2	,	,	,
cord-018182-lleti89n	101	3	if	if	IN
cord-018182-lleti89n	101	4	the	the	DT
cord-018182-lleti89n	101	5	pH	pH	NNP
cord-018182-lleti89n	101	6	and/or	and/or	CC
cord-018182-lleti89n	101	7	the	the	DT
cord-018182-lleti89n	101	8	PaCO	paco	NN
cord-018182-lleti89n	101	9	2	2	CD
cord-018182-lleti89n	101	10	improve	improve	NN
cord-018182-lleti89n	101	11	within	within	IN
cord-018182-lleti89n	101	12	the	the	DT
cord-018182-lleti89n	101	13	first	first	JJ
cord-018182-lleti89n	101	14	few	few	JJ
cord-018182-lleti89n	101	15	hours	hour	NNS
cord-018182-lleti89n	101	16	of	of	IN
cord-018182-lleti89n	101	17	NPPV	NPPV	NNP
cord-018182-lleti89n	101	18	,	,	,
cord-018182-lleti89n	101	19	there	there	EX
cord-018182-lleti89n	101	20	is	be	VBZ
cord-018182-lleti89n	101	21	a	a	DT
cord-018182-lleti89n	101	22	significant	significant	JJ
cord-018182-lleti89n	101	23	probability	probability	NN
cord-018182-lleti89n	101	24	of	of	IN
cord-018182-lleti89n	101	25	success	success	NN
cord-018182-lleti89n	101	26	[	[	-LRB-
cord-018182-lleti89n	101	27	24	24	CD
cord-018182-lleti89n	101	28	]	]	-RRB-
cord-018182-lleti89n	101	29	.	.	.
cord-018182-lleti89n	102	1	Therefore	therefore	RB
cord-018182-lleti89n	102	2	,	,	,
cord-018182-lleti89n	102	3	frequent	frequent	JJ
cord-018182-lleti89n	102	4	monitoring	monitoring	NN
cord-018182-lleti89n	102	5	with	with	IN
cord-018182-lleti89n	102	6	ABGs	abg	NNS
cord-018182-lleti89n	102	7	and	and	CC
cord-018182-lleti89n	102	8	serial	serial	JJ
cord-018182-lleti89n	102	9	clinical	clinical	JJ
cord-018182-lleti89n	102	10	exams	exam	NNS
cord-018182-lleti89n	102	11	is	be	VBZ
cord-018182-lleti89n	102	12	critically	critically	RB
cord-018182-lleti89n	102	13	important	important	JJ
cord-018182-lleti89n	102	14	.	.	.
cord-018182-lleti89n	103	1	When	when	WRB
cord-018182-lleti89n	103	2	interpreting	interpret	VBG
cord-018182-lleti89n	103	3	ABGs	abg	NNS
cord-018182-lleti89n	103	4	,	,	,
cord-018182-lleti89n	103	5	the	the	DT
cord-018182-lleti89n	103	6	acuity	acuity	NN
cord-018182-lleti89n	103	7	of	of	IN
cord-018182-lleti89n	103	8	any	any	DT
cord-018182-lleti89n	103	9	respiratory	respiratory	JJ
cord-018182-lleti89n	103	10	acidosis	acidosis	NN
cord-018182-lleti89n	103	11	should	should	MD
cord-018182-lleti89n	103	12	be	be	VB
cord-018182-lleti89n	103	13	considered	consider	VBN
cord-018182-lleti89n	103	14	given	give	VBN
cord-018182-lleti89n	103	15	that	that	IN
cord-018182-lleti89n	103	16	many	many	JJ
cord-018182-lleti89n	103	17	patients	patient	NNS
cord-018182-lleti89n	103	18	with	with	IN
cord-018182-lleti89n	103	19	COPD	COPD	NNP
cord-018182-lleti89n	103	20	have	have	VBP
cord-018182-lleti89n	103	21	underlying	underlie	VBG
cord-018182-lleti89n	103	22	chronic	chronic	JJ
cord-018182-lleti89n	103	23	hypoxemia	hypoxemia	NN
cord-018182-lleti89n	103	24	and/or	and/or	CC
cord-018182-lleti89n	103	25	hypercapnia	hypercapnia	NN
cord-018182-lleti89n	103	26	.	.	.
cord-018182-lleti89n	104	1	Prior	prior	JJ
cord-018182-lleti89n	104	2	ABGs	abg	NNS
cord-018182-lleti89n	104	3	or	or	CC
cord-018182-lleti89n	104	4	serum	serum	NN
cord-018182-lleti89n	104	5	bicarbonate	bicarbonate	NN
cord-018182-lleti89n	104	6	measurements	measurement	NNS
cord-018182-lleti89n	104	7	during	during	IN
cord-018182-lleti89n	104	8	previous	previous	JJ
cord-018182-lleti89n	104	9	periods	period	NNS
cord-018182-lleti89n	104	10	of	of	IN
cord-018182-lleti89n	104	11	stability	stability	NN
cord-018182-lleti89n	104	12	may	may	MD
cord-018182-lleti89n	104	13	be	be	VB
cord-018182-lleti89n	104	14	useful	useful	JJ
cord-018182-lleti89n	104	15	for	for	IN
cord-018182-lleti89n	104	16	comparison	comparison	NN
cord-018182-lleti89n	104	17	.	.	.
cord-018182-lleti89n	105	1	In	in	IN
cord-018182-lleti89n	105	2	addition	addition	NN
cord-018182-lleti89n	105	3	,	,	,
cord-018182-lleti89n	105	4	consideration	consideration	NN
cord-018182-lleti89n	105	5	of	of	IN
cord-018182-lleti89n	105	6	other	other	JJ
cord-018182-lleti89n	105	7	coexisting	coexist	VBG
cord-018182-lleti89n	105	8	acute	acute	JJ
cord-018182-lleti89n	105	9	or	or	CC
cord-018182-lleti89n	105	10	chronic	chronic	JJ
cord-018182-lleti89n	105	11	conditions	condition	NNS
cord-018182-lleti89n	105	12	that	that	WDT
cord-018182-lleti89n	105	13	might	may	MD
cord-018182-lleti89n	105	14	impact	impact	VB
cord-018182-lleti89n	105	15	on	on	IN
cord-018182-lleti89n	105	16	acid	acid	NN
cord-018182-lleti89n	105	17	-	-	HYPH
cord-018182-lleti89n	105	18	base	base	NN
cord-018182-lleti89n	105	19	balance	balance	NN
cord-018182-lleti89n	105	20	(	(	-LRB-
cord-018182-lleti89n	105	21	e.g.	e.g.	RB
cord-018182-lleti89n	105	22	,	,	,
cord-018182-lleti89n	105	23	acute	acute	JJ
cord-018182-lleti89n	105	24	kidney	kidney	NN
cord-018182-lleti89n	105	25	injury	injury	NN
cord-018182-lleti89n	105	26	or	or	CC
cord-018182-lleti89n	105	27	chronic	chronic	JJ
cord-018182-lleti89n	105	28	kidney	kidney	NN
cord-018182-lleti89n	105	29	disease	disease	NN
cord-018182-lleti89n	105	30	stage	stage	NN
cord-018182-lleti89n	105	31	III	III	NNP
cord-018182-lleti89n	105	32	or	or	CC
cord-018182-lleti89n	105	33	greater	great	JJR
cord-018182-lleti89n	105	34	)	)	-RRB-
cord-018182-lleti89n	105	35	is	be	VBZ
cord-018182-lleti89n	105	36	also	also	RB
cord-018182-lleti89n	105	37	important	important	JJ
cord-018182-lleti89n	105	38	to	to	IN
cord-018182-lleti89n	105	39	successful	successful	JJ
cord-018182-lleti89n	105	40	ABG	ABG	NNP
cord-018182-lleti89n	105	41	interpretation	interpretation	NN
cord-018182-lleti89n	105	42	and	and	CC
cord-018182-lleti89n	105	43	clinical	clinical	JJ
cord-018182-lleti89n	105	44	application	application	NN
cord-018182-lleti89n	105	45	.	.	.
cord-018182-lleti89n	106	1	Although	although	IN
cord-018182-lleti89n	106	2	NPPV	NPPV	NNP
cord-018182-lleti89n	106	3	can	can	MD
cord-018182-lleti89n	106	4	rescue	rescue	VB
cord-018182-lleti89n	106	5	many	many	JJ
cord-018182-lleti89n	106	6	from	from	IN
cord-018182-lleti89n	106	7	respiratory	respiratory	JJ
cord-018182-lleti89n	106	8	failure	failure	NN
cord-018182-lleti89n	106	9	,	,	,
cord-018182-lleti89n	106	10	invasive	invasive	JJ
cord-018182-lleti89n	106	11	mechanical	mechanical	JJ
cord-018182-lleti89n	106	12	ventilation	ventilation	NN
cord-018182-lleti89n	106	13	may	may	MD
cord-018182-lleti89n	106	14	be	be	VB
cord-018182-lleti89n	106	15	necessary	necessary	JJ
cord-018182-lleti89n	106	16	in	in	IN
cord-018182-lleti89n	106	17	patients	patient	NNS
cord-018182-lleti89n	106	18	with	with	IN
cord-018182-lleti89n	106	19	particularly	particularly	RB
cord-018182-lleti89n	106	20	severe	severe	JJ
cord-018182-lleti89n	106	21	exacerbations	exacerbation	NNS
cord-018182-lleti89n	106	22	.	.	.
cord-018182-lleti89n	107	1	Intubation	intubation	NN
cord-018182-lleti89n	107	2	should	should	MD
cord-018182-lleti89n	107	3	be	be	VB
cord-018182-lleti89n	107	4	considered	consider	VBN
cord-018182-lleti89n	107	5	in	in	IN
cord-018182-lleti89n	107	6	patients	patient	NNS
cord-018182-lleti89n	107	7	with	with	IN
cord-018182-lleti89n	107	8	NPPV	NPPV	NNP
cord-018182-lleti89n	107	9	failure	failure	NN
cord-018182-lleti89n	107	10	or	or	CC
cord-018182-lleti89n	107	11	contraindication	contraindication	NN
cord-018182-lleti89n	107	12	,	,	,
cord-018182-lleti89n	107	13	severe	severe	JJ
cord-018182-lleti89n	107	14	acidosis	acidosis	NN
cord-018182-lleti89n	107	15	and	and	CC
cord-018182-lleti89n	107	16	hypercapnia	hypercapnia	NN
cord-018182-lleti89n	108	1	(	(	-LRB-
cord-018182-lleti89n	108	2	pH	pH	NNP
cord-018182-lleti89n	108	3	<	<	XX
cord-018182-lleti89n	108	4	7.25	7.25	CD
cord-018182-lleti89n	108	5	and/or	and/or	CC
cord-018182-lleti89n	108	6	PCO	PCO	NNP
cord-018182-lleti89n	108	7	2	2	CD
cord-018182-lleti89n	108	8	>	>	SYM
cord-018182-lleti89n	108	9	60	60	CD
cord-018182-lleti89n	108	10	mmHg	mmHg	NNS
cord-018182-lleti89n	108	11	)	)	-RRB-
cord-018182-lleti89n	108	12	,	,	,
cord-018182-lleti89n	108	13	life	life	NN
cord-018182-lleti89n	108	14	-	-	HYPH
cord-018182-lleti89n	108	15	threatening	threaten	VBG
cord-018182-lleti89n	108	16	hypoxia	hypoxia	NN
cord-018182-lleti89n	108	17	,	,	,
cord-018182-lleti89n	108	18	or	or	CC
cord-018182-lleti89n	108	19	tachypnea	tachypnea	NN
cord-018182-lleti89n	108	20	with	with	IN
cord-018182-lleti89n	108	21	impending	impending	JJ
cord-018182-lleti89n	108	22	evidence	evidence	NN
cord-018182-lleti89n	108	23	of	of	IN
cord-018182-lleti89n	108	24	acute	acute	JJ
cord-018182-lleti89n	108	25	respiratory	respiratory	JJ
cord-018182-lleti89n	108	26	failure	failure	NN
cord-018182-lleti89n	108	27	[	[	-LRB-
cord-018182-lleti89n	108	28	1	1	CD
cord-018182-lleti89n	108	29	]	]	-RRB-
cord-018182-lleti89n	108	30	.	.	.
cord-018182-lleti89n	109	1	Table	table	NN
cord-018182-lleti89n	109	2	13	13	CD
cord-018182-lleti89n	109	3	.5	.5	NN
cord-018182-lleti89n	109	4	summarizes	summarize	VBZ
cord-018182-lleti89n	109	5	indications	indication	NNS
cord-018182-lleti89n	109	6	for	for	IN
cord-018182-lleti89n	109	7	invasive	invasive	JJ
cord-018182-lleti89n	109	8	mechanical	mechanical	JJ
cord-018182-lleti89n	109	9	ventilation	ventilation	NN
cord-018182-lleti89n	109	10	.	.	.
cord-018182-lleti89n	110	1	In	in	IN
cord-018182-lleti89n	110	2	general	general	JJ
cord-018182-lleti89n	110	3	,	,	,
cord-018182-lleti89n	110	4	assist	assist	VB
cord-018182-lleti89n	110	5	-	-	HYPH
cord-018182-lleti89n	110	6	control	control	NN
cord-018182-lleti89n	110	7	volume	volume	NN
cord-018182-lleti89n	110	8	-	-	HYPH
cord-018182-lleti89n	110	9	cycled	cycle	VBN
cord-018182-lleti89n	110	10	ventilation	ventilation	NN
cord-018182-lleti89n	110	11	is	be	VBZ
cord-018182-lleti89n	110	12	recommended	recommend	VBN
cord-018182-lleti89n	110	13	for	for	IN
cord-018182-lleti89n	110	14	patients	patient	NNS
cord-018182-lleti89n	110	15	with	with	IN
cord-018182-lleti89n	110	16	severe	severe	JJ
cord-018182-lleti89n	110	17	obstructive	obstructive	JJ
cord-018182-lleti89n	110	18	lung	lung	NN
cord-018182-lleti89n	110	19	disease	disease	NN
cord-018182-lleti89n	110	20	.	.	.
cord-018182-lleti89n	111	1	This	this	DT
cord-018182-lleti89n	111	2	allows	allow	VBZ
cord-018182-lleti89n	111	3	for	for	IN
cord-018182-lleti89n	111	4	careful	careful	JJ
cord-018182-lleti89n	111	5	control	control	NN
cord-018182-lleti89n	111	6	of	of	IN
cord-018182-lleti89n	111	7	minute	minute	NN
cord-018182-lleti89n	111	8	ventilation	ventilation	NN
cord-018182-lleti89n	111	9	,	,	,
cord-018182-lleti89n	111	10	tidal	tidal	JJ
cord-018182-lleti89n	111	11	volume	volume	NN
cord-018182-lleti89n	111	12	,	,	,
cord-018182-lleti89n	111	13	inspiratory	inspiratory	JJ
cord-018182-lleti89n	111	14	flow	flow	NN
cord-018182-lleti89n	111	15	rate	rate	NN
cord-018182-lleti89n	111	16	,	,	,
cord-018182-lleti89n	111	17	and	and	CC
cord-018182-lleti89n	111	18	expiratory	expiratory	JJ
cord-018182-lleti89n	111	19	flow	flow	NN
cord-018182-lleti89n	111	20	time	time	NN
cord-018182-lleti89n	111	21	given	give	VBN
cord-018182-lleti89n	111	22	the	the	DT
cord-018182-lleti89n	111	23	predisposition	predisposition	NN
cord-018182-lleti89n	111	24	for	for	IN
cord-018182-lleti89n	111	25	this	this	DT
cord-018182-lleti89n	111	26	patient	patient	JJ
cord-018182-lleti89n	111	27	population	population	NN
cord-018182-lleti89n	111	28	to	to	TO
cord-018182-lleti89n	111	29	experience	experience	VB
cord-018182-lleti89n	111	30	dynamic	dynamic	JJ
cord-018182-lleti89n	111	31	hyperinflation	hyperinflation	NN
cord-018182-lleti89n	111	32	and	and	CC
cord-018182-lleti89n	111	33	ventilator	ventilator	NN
cord-018182-lleti89n	111	34	-	-	HYPH
cord-018182-lleti89n	111	35	induced	induce	VBN
cord-018182-lleti89n	111	36	lung	lung	NN
cord-018182-lleti89n	111	37	injury	injury	NN
cord-018182-lleti89n	111	38	.	.	.
cord-018182-lleti89n	112	1	Specific	specific	JJ
cord-018182-lleti89n	112	2	recommendations	recommendation	NNS
cord-018182-lleti89n	112	3	for	for	IN
cord-018182-lleti89n	112	4	ventilator	ventilator	NN
cord-018182-lleti89n	112	5	parameters	parameter	NNS
cord-018182-lleti89n	112	6	are	be	VBP
cord-018182-lleti89n	112	7	summarized	summarize	VBN
cord-018182-lleti89n	112	8	in	in	IN
cord-018182-lleti89n	112	9	Table	Table	NNP
cord-018182-lleti89n	112	10	13	13	CD
cord-018182-lleti89n	112	11	.6	.6	CD
cord-018182-lleti89n	112	12	.	.	.
cord-018182-lleti89n	113	1	It	-PRON-	PRP
cord-018182-lleti89n	113	2	should	should	MD
cord-018182-lleti89n	113	3	be	be	VB
cord-018182-lleti89n	113	4	noted	note	VBN
cord-018182-lleti89n	113	5	that	that	IN
cord-018182-lleti89n	113	6	no	no	DT
cord-018182-lleti89n	113	7	specific	specific	JJ
cord-018182-lleti89n	113	8	trials	trial	NNS
cord-018182-lleti89n	113	9	have	have	VBP
cord-018182-lleti89n	113	10	been	be	VBN
cord-018182-lleti89n	113	11	performed	perform	VBN
cord-018182-lleti89n	113	12	to	to	TO
cord-018182-lleti89n	113	13	determine	determine	VB
cord-018182-lleti89n	113	14	optimal	optimal	JJ
cord-018182-lleti89n	113	15	ventilator	ventilator	NN
cord-018182-lleti89n	113	16	settings	setting	NNS
cord-018182-lleti89n	113	17	in	in	IN
cord-018182-lleti89n	113	18	patients	patient	NNS
cord-018182-lleti89n	113	19	with	with	IN
cord-018182-lleti89n	113	20	AECOPD	AECOPD	NNP
cord-018182-lleti89n	113	21	.	.	.
cord-018182-lleti89n	114	1	It	-PRON-	PRP
cord-018182-lleti89n	114	2	is	be	VBZ
cord-018182-lleti89n	114	3	likely	likely	JJ
cord-018182-lleti89n	114	4	that	that	IN
cord-018182-lleti89n	114	5	every	every	DT
cord-018182-lleti89n	114	6	patient	patient	NN
cord-018182-lleti89n	114	7	will	will	MD
cord-018182-lleti89n	114	8	respond	respond	VB
cord-018182-lleti89n	114	9	differently	differently	RB
cord-018182-lleti89n	114	10	depending	depend	VBG
cord-018182-lleti89n	114	11	on	on	IN
cord-018182-lleti89n	114	12	the	the	DT
cord-018182-lleti89n	114	13	severity	severity	NN
cord-018182-lleti89n	114	14	of	of	IN
cord-018182-lleti89n	114	15	underlying	underlie	VBG
cord-018182-lleti89n	114	16	lung	lung	NN
cord-018182-lleti89n	114	17	disease	disease	NN
cord-018182-lleti89n	114	18	,	,	,
cord-018182-lleti89n	114	19	existence	existence	NN
cord-018182-lleti89n	114	20	and	and	CC
cord-018182-lleti89n	114	21	severity	severity	NN
cord-018182-lleti89n	114	22	of	of	IN
cord-018182-lleti89n	114	23	other	other	JJ
cord-018182-lleti89n	114	24	comorbidities	comorbiditie	NNS
cord-018182-lleti89n	114	25	,	,	,
cord-018182-lleti89n	114	26	and	and	CC
cord-018182-lleti89n	114	27	degree	degree	NN
cord-018182-lleti89n	114	28	of	of	IN
cord-018182-lleti89n	114	29	ventilator	ventilator	NN
cord-018182-lleti89n	114	30	synchrony	synchrony	NN
cord-018182-lleti89n	114	31	.	.	.
cord-018182-lleti89n	115	1	Careful	careful	JJ
cord-018182-lleti89n	115	2	titration	titration	NN
cord-018182-lleti89n	115	3	and	and	CC
cord-018182-lleti89n	115	4	adjustment	adjustment	NN
cord-018182-lleti89n	115	5	of	of	IN
cord-018182-lleti89n	115	6	ventilator	ventilator	NN
cord-018182-lleti89n	115	7	settings	setting	NNS
cord-018182-lleti89n	115	8	at	at	IN
cord-018182-lleti89n	115	9	the	the	DT
cord-018182-lleti89n	115	10	bedside	bedside	NN
cord-018182-lleti89n	115	11	is	be	VBZ
cord-018182-lleti89n	115	12	often	often	RB
cord-018182-lleti89n	115	13	necessary	necessary	JJ
cord-018182-lleti89n	115	14	given	give	VBN
cord-018182-lleti89n	115	15	the	the	DT
cord-018182-lleti89n	115	16	dynamic	dynamic	JJ
cord-018182-lleti89n	115	17	nature	nature	NN
cord-018182-lleti89n	115	18	of	of	IN
cord-018182-lleti89n	115	19	respiratory	respiratory	JJ
cord-018182-lleti89n	115	20	failure	failure	NN
cord-018182-lleti89n	115	21	in	in	IN
cord-018182-lleti89n	115	22	this	this	DT
cord-018182-lleti89n	115	23	patient	patient	JJ
cord-018182-lleti89n	115	24	population	population	NN
cord-018182-lleti89n	115	25	.	.	.
cord-018182-lleti89n	116	1	Consultation	consultation	NN
cord-018182-lleti89n	116	2	with	with	IN
cord-018182-lleti89n	116	3	a	a	DT
cord-018182-lleti89n	116	4	pulmonologist	pulmonologist	NN
cord-018182-lleti89n	116	5	with	with	IN
cord-018182-lleti89n	116	6	specific	specific	JJ
cord-018182-lleti89n	116	7	expertise	expertise	NN
cord-018182-lleti89n	116	8	in	in	IN
cord-018182-lleti89n	116	9	COPD	COPD	NNP
cord-018182-lleti89n	116	10	management	management	NN
cord-018182-lleti89n	116	11	may	may	MD
cord-018182-lleti89n	116	12	be	be	VB
cord-018182-lleti89n	116	13	necessary	necessary	JJ
cord-018182-lleti89n	116	14	in	in	IN
cord-018182-lleti89n	116	15	select	select	JJ
cord-018182-lleti89n	116	16	,	,	,
cord-018182-lleti89n	116	17	severe	severe	JJ
cord-018182-lleti89n	116	18	cases	case	NNS
cord-018182-lleti89n	116	19	in	in	IN
cord-018182-lleti89n	116	20	which	which	WDT
cord-018182-lleti89n	116	21	ventilator	ventilator	NN
cord-018182-lleti89n	116	22	management	management	NN
cord-018182-lleti89n	116	23	is	be	VBZ
cord-018182-lleti89n	116	24	a	a	DT
cord-018182-lleti89n	116	25	challenge	challenge	NN
cord-018182-lleti89n	116	26	.	.	.
cord-018182-lleti89n	117	1	Adjustments	adjustment	NNS
cord-018182-lleti89n	117	2	should	should	MD
cord-018182-lleti89n	117	3	not	not	RB
cord-018182-lleti89n	117	4	be	be	VB
cord-018182-lleti89n	117	5	made	make	VBN
cord-018182-lleti89n	117	6	solely	solely	RB
cord-018182-lleti89n	117	7	on	on	IN
cord-018182-lleti89n	117	8	the	the	DT
cord-018182-lleti89n	117	9	basis	basis	NN
cord-018182-lleti89n	117	10	of	of	IN
cord-018182-lleti89n	117	11	gas	gas	NN
cord-018182-lleti89n	117	12	exchange	exchange	NN
cord-018182-lleti89n	117	13	from	from	IN
cord-018182-lleti89n	117	14	ABG	ABG	NNP
cord-018182-lleti89n	117	15	results	result	NNS
cord-018182-lleti89n	117	16	,	,	,
cord-018182-lleti89n	117	17	rather	rather	RB
cord-018182-lleti89n	117	18	in	in	IN
cord-018182-lleti89n	117	19	conjunction	conjunction	NN
cord-018182-lleti89n	117	20	with	with	IN
cord-018182-lleti89n	117	21	close	close	JJ
cord-018182-lleti89n	117	22	monitoring	monitoring	NN
cord-018182-lleti89n	117	23	of	of	IN
cord-018182-lleti89n	117	24	the	the	DT
cord-018182-lleti89n	117	25	clinical	clinical	JJ
cord-018182-lleti89n	117	26	exam	exam	NN
cord-018182-lleti89n	117	27	including	include	VBG
cord-018182-lleti89n	117	28	patient	patient	NN
cord-018182-lleti89n	117	29	-	-	HYPH
cord-018182-lleti89n	117	30	ventilator	ventilator	NN
cord-018182-lleti89n	117	31	synchrony	synchrony	NN
cord-018182-lleti89n	117	32	,	,	,
cord-018182-lleti89n	117	33	work	work	NN
cord-018182-lleti89n	117	34	of	of	IN
cord-018182-lleti89n	117	35	breathing	breathing	NN
cord-018182-lleti89n	117	36	,	,	,
cord-018182-lleti89n	117	37	and	and	CC
cord-018182-lleti89n	117	38	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	117	39	parameters	parameter	NNS
cord-018182-lleti89n	117	40	.	.	.
cord-018182-lleti89n	118	1	Sedation	sedation	NN
cord-018182-lleti89n	118	2	and	and	CC
cord-018182-lleti89n	118	3	analgesia	analgesia	NN
cord-018182-lleti89n	118	4	are	be	VBP
cord-018182-lleti89n	118	5	also	also	RB
cord-018182-lleti89n	118	6	important	important	JJ
cord-018182-lleti89n	118	7	to	to	IN
cord-018182-lleti89n	118	8	successful	successful	JJ
cord-018182-lleti89n	118	9	ventilator	ventilator	NN
cord-018182-lleti89n	118	10	management	management	NN
cord-018182-lleti89n	118	11	.	.	.
cord-018182-lleti89n	119	1	Auto	auto	NN
cord-018182-lleti89n	119	2	-	-	HYPH
cord-018182-lleti89n	119	3	PEEP	PEEP	NNP
cord-018182-lleti89n	119	4	is	be	VBZ
cord-018182-lleti89n	119	5	an	an	DT
cord-018182-lleti89n	119	6	important	important	JJ
cord-018182-lleti89n	119	7	consideration	consideration	NN
cord-018182-lleti89n	119	8	in	in	IN
cord-018182-lleti89n	119	9	patients	patient	NNS
cord-018182-lleti89n	119	10	with	with	IN
cord-018182-lleti89n	119	11	severe	severe	JJ
cord-018182-lleti89n	119	12	obstructive	obstructive	JJ
cord-018182-lleti89n	119	13	lung	lung	NN
cord-018182-lleti89n	119	14	disease	disease	NN
cord-018182-lleti89n	119	15	.	.	.
cord-018182-lleti89n	120	1	Positive	positive	JJ
cord-018182-lleti89n	120	2	end	end	NN
cord-018182-lleti89n	120	3	-	-	HYPH
cord-018182-lleti89n	120	4	expiratory	expiratory	NN
cord-018182-lleti89n	120	5	pressure	pressure	NN
cord-018182-lleti89n	120	6	(	(	-LRB-
cord-018182-lleti89n	120	7	PEEP	peep	NN
cord-018182-lleti89n	120	8	)	)	-RRB-
cord-018182-lleti89n	120	9	is	be	VBZ
cord-018182-lleti89n	120	10	the	the	DT
cord-018182-lleti89n	120	11	pressure	pressure	NN
cord-018182-lleti89n	120	12	in	in	IN
cord-018182-lleti89n	120	13	the	the	DT
cord-018182-lleti89n	120	14	alveolus	alveolus	NN
cord-018182-lleti89n	120	15	at	at	IN
cord-018182-lleti89n	120	16	the	the	DT
cord-018182-lleti89n	120	17	end	end	NN
cord-018182-lleti89n	120	18	of	of	IN
cord-018182-lleti89n	120	19	exhalation	exhalation	NN
cord-018182-lleti89n	120	20	.	.	.
cord-018182-lleti89n	121	1	In	in	IN
cord-018182-lleti89n	121	2	patients	patient	NNS
cord-018182-lleti89n	121	3	with	with	IN
cord-018182-lleti89n	121	4	COPD	COPD	NNP
cord-018182-lleti89n	121	5	,	,	,
cord-018182-lleti89n	121	6	increased	increase	VBN
cord-018182-lleti89n	121	7	airway	airway	NN
cord-018182-lleti89n	121	8	resistance	resistance	NN
cord-018182-lleti89n	121	9	may	may	MD
cord-018182-lleti89n	121	10	result	result	VB
cord-018182-lleti89n	121	11	in	in	IN
cord-018182-lleti89n	121	12	incomplete	incomplete	JJ
cord-018182-lleti89n	121	13	deflation	deflation	NN
cord-018182-lleti89n	121	14	of	of	IN
cord-018182-lleti89n	121	15	the	the	DT
cord-018182-lleti89n	121	16	lungs	lung	NNS
cord-018182-lleti89n	121	17	prior	prior	RB
cord-018182-lleti89n	121	18	to	to	IN
cord-018182-lleti89n	121	19	initiation	initiation	NN
cord-018182-lleti89n	121	20	of	of	IN
cord-018182-lleti89n	121	21	the	the	DT
cord-018182-lleti89n	121	22	next	next	JJ
cord-018182-lleti89n	121	23	breath	breath	NN
cord-018182-lleti89n	121	24	,	,	,
cord-018182-lleti89n	121	25	causing	cause	VBG
cord-018182-lleti89n	121	26	the	the	DT
cord-018182-lleti89n	121	27	intra	intra	JJ
cord-018182-lleti89n	121	28	-	-	JJ
cord-018182-lleti89n	121	29	alveolar	alveolar	JJ
cord-018182-lleti89n	121	30	volume	volume	NN
cord-018182-lleti89n	121	31	and	and	CC
cord-018182-lleti89n	121	32	therefore	therefore	RB
cord-018182-lleti89n	121	33	pressure	pressure	NN
cord-018182-lleti89n	121	34	to	to	TO
cord-018182-lleti89n	121	35	remain	remain	VB
cord-018182-lleti89n	121	36	elevated	elevated	JJ
cord-018182-lleti89n	121	37	above	above	IN
cord-018182-lleti89n	121	38	that	that	DT
cord-018182-lleti89n	121	39	which	which	WDT
cord-018182-lleti89n	121	40	is	be	VBZ
cord-018182-lleti89n	121	41	desired	desire	VBN
cord-018182-lleti89n	121	42	.	.	.
cord-018182-lleti89n	122	1	This	this	DT
cord-018182-lleti89n	122	2	dynamic	dynamic	JJ
cord-018182-lleti89n	122	3	hyperinflation	hyperinflation	NN
cord-018182-lleti89n	122	4	creates	create	VBZ
cord-018182-lleti89n	122	5	auto	auto	NN
cord-018182-lleti89n	122	6	-	-	HYPH
cord-018182-lleti89n	122	7	PEEP	peep	NN
cord-018182-lleti89n	122	8	(	(	-LRB-
cord-018182-lleti89n	122	9	in	in	IN
cord-018182-lleti89n	122	10	contrast	contrast	NN
cord-018182-lleti89n	122	11	to	to	IN
cord-018182-lleti89n	122	12	the	the	DT
cord-018182-lleti89n	122	13	intentional	intentional	JJ
cord-018182-lleti89n	122	14	application	application	NN
cord-018182-lleti89n	122	15	of	of	IN
cord-018182-lleti89n	122	16	extrinsic	extrinsic	JJ
cord-018182-lleti89n	122	17	PEEP	peep	NN
cord-018182-lleti89n	122	18	via	via	IN
cord-018182-lleti89n	122	19	mechanical	mechanical	JJ
cord-018182-lleti89n	122	20	ventilation	ventilation	NN
cord-018182-lleti89n	122	21	)	)	-RRB-
cord-018182-lleti89n	122	22	.	.	.
cord-018182-lleti89n	123	1	The	the	DT
cord-018182-lleti89n	123	2	presence	presence	NN
cord-018182-lleti89n	123	3	of	of	IN
cord-018182-lleti89n	123	4	auto	auto	NN
cord-018182-lleti89n	123	5	-	-	HYPH
cord-018182-lleti89n	123	6	PEEP	PEEP	NNP
cord-018182-lleti89n	123	7	is	be	VBZ
cord-018182-lleti89n	123	8	important	important	JJ
cord-018182-lleti89n	123	9	as	as	IN
cord-018182-lleti89n	123	10	it	-PRON-	PRP
cord-018182-lleti89n	123	11	can	can	MD
cord-018182-lleti89n	123	12	increase	increase	VB
cord-018182-lleti89n	123	13	the	the	DT
cord-018182-lleti89n	123	14	work	work	NN
cord-018182-lleti89n	123	15	of	of	IN
cord-018182-lleti89n	123	16	breathing	breathing	NN
cord-018182-lleti89n	123	17	,	,	,
cord-018182-lleti89n	123	18	trigger	trigger	NN
cord-018182-lleti89n	123	19	patient	patient	NN
cord-018182-lleti89n	123	20	-	-	HYPH
cord-018182-lleti89n	123	21	ventilator	ventilator	NN
cord-018182-lleti89n	123	22	dyssynchrony	dyssynchrony	NN
cord-018182-lleti89n	123	23	,	,	,
cord-018182-lleti89n	123	24	and	and	CC
cord-018182-lleti89n	123	25	worsen	worsen	VB
cord-018182-lleti89n	123	26	gas	gas	NN
cord-018182-lleti89n	123	27	exchange	exchange	NN
cord-018182-lleti89n	123	28	.	.	.
cord-018182-lleti89n	124	1	Auto	auto	NN
cord-018182-lleti89n	124	2	-	-	HYPH
cord-018182-lleti89n	124	3	PEEP	PEEP	NNP
cord-018182-lleti89n	124	4	may	may	MD
cord-018182-lleti89n	124	5	result	result	VB
cord-018182-lleti89n	124	6	in	in	IN
cord-018182-lleti89n	124	7	misinterpretation	misinterpretation	NN
cord-018182-lleti89n	124	8	of	of	IN
cord-018182-lleti89n	124	9	clinical	clinical	JJ
cord-018182-lleti89n	124	10	data	datum	NNS
cord-018182-lleti89n	124	11	such	such	JJ
cord-018182-lleti89n	124	12	as	as	IN
cord-018182-lleti89n	124	13	central	central	JJ
cord-018182-lleti89n	124	14	venous	venous	JJ
cord-018182-lleti89n	124	15	or	or	CC
cord-018182-lleti89n	124	16	pulmonary	pulmonary	JJ
cord-018182-lleti89n	124	17	arterial	arterial	JJ
cord-018182-lleti89n	124	18	catheter	catheter	NN
cord-018182-lleti89n	124	19	measurements	measurement	NNS
cord-018182-lleti89n	124	20	and	and	CC
cord-018182-lleti89n	124	21	lead	lead	VBP
cord-018182-lleti89n	124	22	to	to	IN
cord-018182-lleti89n	124	23	unnecessary	unnecessary	JJ
cord-018182-lleti89n	124	24	treatments	treatment	NNS
cord-018182-lleti89n	124	25	such	such	JJ
cord-018182-lleti89n	124	26	as	as	IN
cord-018182-lleti89n	124	27	higher	high	JJR
cord-018182-lleti89n	124	28	doses	dose	NNS
cord-018182-lleti89n	124	29	of	of	IN
cord-018182-lleti89n	124	30	sedative	sedative	JJ
cord-018182-lleti89n	124	31	medications	medication	NNS
cord-018182-lleti89n	124	32	[	[	-LRB-
cord-018182-lleti89n	124	33	25	25	CD
cord-018182-lleti89n	124	34	]	]	-RRB-
cord-018182-lleti89n	124	35	.	.	.
cord-018182-lleti89n	125	1	Auto	auto	NN
cord-018182-lleti89n	125	2	-	-	HYPH
cord-018182-lleti89n	125	3	PEEP	PEEP	NNP
cord-018182-lleti89n	125	4	may	may	MD
cord-018182-lleti89n	125	5	also	also	RB
cord-018182-lleti89n	125	6	provoke	provoke	VB
cord-018182-lleti89n	125	7	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	125	8	compromise	compromise	NN
cord-018182-lleti89n	125	9	by	by	IN
cord-018182-lleti89n	125	10	increasing	increase	VBG
cord-018182-lleti89n	125	11	intrathoracic	intrathoracic	JJ
cord-018182-lleti89n	125	12	pressure	pressure	NN
cord-018182-lleti89n	125	13	that	that	WDT
cord-018182-lleti89n	125	14	results	result	VBZ
cord-018182-lleti89n	125	15	in	in	IN
cord-018182-lleti89n	125	16	decreases	decrease	NNS
cord-018182-lleti89n	125	17	in	in	IN
cord-018182-lleti89n	125	18	right	right	NN
cord-018182-lleti89n	125	19	and	and	CC
cord-018182-lleti89n	125	20	left	left	JJ
cord-018182-lleti89n	125	21	ventricular	ventricular	JJ
cord-018182-lleti89n	125	22	preload	preload	NN
cord-018182-lleti89n	125	23	,	,	,
cord-018182-lleti89n	125	24	ultimately	ultimately	RB
cord-018182-lleti89n	125	25	leading	lead	VBG
cord-018182-lleti89n	125	26	to	to	IN
cord-018182-lleti89n	125	27	arterial	arterial	JJ
cord-018182-lleti89n	125	28	hypotension	hypotension	NN
cord-018182-lleti89n	125	29	.	.	.
cord-018182-lleti89n	126	1	Misdiagnosis	misdiagnosis	NN
cord-018182-lleti89n	126	2	of	of	IN
cord-018182-lleti89n	126	3	the	the	DT
cord-018182-lleti89n	126	4	etiology	etiology	NN
cord-018182-lleti89n	126	5	of	of	IN
cord-018182-lleti89n	126	6	shock	shock	NN
cord-018182-lleti89n	126	7	in	in	IN
cord-018182-lleti89n	126	8	this	this	DT
cord-018182-lleti89n	126	9	setting	setting	NN
cord-018182-lleti89n	126	10	may	may	MD
cord-018182-lleti89n	126	11	lead	lead	VB
cord-018182-lleti89n	126	12	to	to	IN
cord-018182-lleti89n	126	13	unnecessary	unnecessary	JJ
cord-018182-lleti89n	126	14	fluid	fluid	NN
cord-018182-lleti89n	126	15	and	and	CC
cord-018182-lleti89n	126	16	vasopressor	vasopressor	NNP
cord-018182-lleti89n	126	17	administration	administration	NN
cord-018182-lleti89n	126	18	;	;	:
cord-018182-lleti89n	126	19	failure	failure	NN
cord-018182-lleti89n	126	20	to	to	TO
cord-018182-lleti89n	126	21	recognize	recognize	VB
cord-018182-lleti89n	126	22	and	and	CC
cord-018182-lleti89n	126	23	correct	correct	VB
cord-018182-lleti89n	126	24	auto	auto	NN
cord-018182-lleti89n	126	25	-	-	HYPH
cord-018182-lleti89n	126	26	PEEP	peep	NN
cord-018182-lleti89n	126	27	may	may	MD
cord-018182-lleti89n	126	28	result	result	VB
cord-018182-lleti89n	126	29	in	in	IN
cord-018182-lleti89n	126	30	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	126	31	collapse	collapse	NN
cord-018182-lleti89n	126	32	and	and	CC
cord-018182-lleti89n	126	33	death	death	NN
cord-018182-lleti89n	126	34	.	.	.
cord-018182-lleti89n	127	1	For	for	IN
cord-018182-lleti89n	127	2	this	this	DT
cord-018182-lleti89n	127	3	reason	reason	NN
cord-018182-lleti89n	127	4	,	,	,
cord-018182-lleti89n	127	5	any	any	DT
cord-018182-lleti89n	127	6	mechanically	mechanically	RB
cord-018182-lleti89n	127	7	ventilated	ventilate	VBN
cord-018182-lleti89n	127	8	patient	patient	NN
cord-018182-lleti89n	127	9	with	with	IN
cord-018182-lleti89n	127	10	COPD	COPD	NNP
cord-018182-lleti89n	127	11	and	and	CC
cord-018182-lleti89n	127	12	new	new	JJ
cord-018182-lleti89n	127	13	onset	onset	NN
cord-018182-lleti89n	127	14	hypotension	hypotension	NN
cord-018182-lleti89n	127	15	should	should	MD
cord-018182-lleti89n	127	16	be	be	VB
cord-018182-lleti89n	127	17	assessed	assess	VBN
cord-018182-lleti89n	127	18	for	for	IN
cord-018182-lleti89n	127	19	the	the	DT
cord-018182-lleti89n	127	20	presence	presence	NN
cord-018182-lleti89n	127	21	Minute	minute	NN
cord-018182-lleti89n	127	22	ventilation	ventilation	NN
cord-018182-lleti89n	127	23	requirements	requirement	NNS
cord-018182-lleti89n	127	24	will	will	MD
cord-018182-lleti89n	127	25	vary	vary	VB
cord-018182-lleti89n	127	26	by	by	IN
cord-018182-lleti89n	127	27	patient	patient	NN
cord-018182-lleti89n	127	28	,	,	,
cord-018182-lleti89n	127	29	and	and	CC
cord-018182-lleti89n	127	30	settings	setting	NNS
cord-018182-lleti89n	127	31	for	for	IN
cord-018182-lleti89n	127	32	tidal	tidal	JJ
cord-018182-lleti89n	127	33	volume	volume	NN
cord-018182-lleti89n	127	34	and	and	CC
cord-018182-lleti89n	127	35	respiratory	respiratory	JJ
cord-018182-lleti89n	127	36	rate	rate	NN
cord-018182-lleti89n	127	37	will	will	MD
cord-018182-lleti89n	127	38	need	need	VB
cord-018182-lleti89n	127	39	to	to	TO
cord-018182-lleti89n	127	40	be	be	VB
cord-018182-lleti89n	127	41	considered	consider	VBN
cord-018182-lleti89n	127	42	on	on	IN
cord-018182-lleti89n	127	43	an	an	DT
cord-018182-lleti89n	127	44	individual	individual	JJ
cord-018182-lleti89n	127	45	basis	basis	NN
cord-018182-lleti89n	127	46	.	.	.
cord-018182-lleti89n	128	1	High	high	JJ
cord-018182-lleti89n	128	2	respiratory	respiratory	JJ
cord-018182-lleti89n	128	3	rates	rate	NNS
cord-018182-lleti89n	128	4	may	may	MD
cord-018182-lleti89n	128	5	provoke	provoke	VB
cord-018182-lleti89n	128	6	a	a	DT
cord-018182-lleti89n	128	7	shortened	shorten	VBN
cord-018182-lleti89n	128	8	expiratory	expiratory	JJ
cord-018182-lleti89n	128	9	phase	phase	NN
cord-018182-lleti89n	128	10	and	and	CC
cord-018182-lleti89n	128	11	lead	lead	VB
cord-018182-lleti89n	128	12	to	to	IN
cord-018182-lleti89n	128	13	air	air	NN
cord-018182-lleti89n	128	14	trapping	trapping	NN
cord-018182-lleti89n	128	15	,	,	,
cord-018182-lleti89n	128	16	auto	auto	NN
cord-018182-lleti89n	128	17	-	-	HYPH
cord-018182-lleti89n	128	18	PEEP	peep	NN
cord-018182-lleti89n	128	19	,	,	,
cord-018182-lleti89n	128	20	and	and	CC
cord-018182-lleti89n	128	21	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	128	22	compromise	compromise	NN
cord-018182-lleti89n	128	23	of	of	IN
cord-018182-lleti89n	128	24	auto	auto	NN
cord-018182-lleti89n	128	25	-	-	HYPH
cord-018182-lleti89n	128	26	PEEP	peep	NN
cord-018182-lleti89n	128	27	.	.	.
cord-018182-lleti89n	129	1	If	if	IN
cord-018182-lleti89n	129	2	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	129	3	compromise	compromise	NN
cord-018182-lleti89n	129	4	from	from	IN
cord-018182-lleti89n	129	5	auto	auto	NN
cord-018182-lleti89n	129	6	-	-	HYPH
cord-018182-lleti89n	129	7	PEEP	PEEP	NNP
cord-018182-lleti89n	129	8	is	be	VBZ
cord-018182-lleti89n	129	9	present	present	JJ
cord-018182-lleti89n	129	10	,	,	,
cord-018182-lleti89n	129	11	disconnection	disconnection	NN
cord-018182-lleti89n	129	12	from	from	IN
cord-018182-lleti89n	129	13	the	the	DT
cord-018182-lleti89n	129	14	ventilator	ventilator	NN
cord-018182-lleti89n	129	15	circuit	circuit	NN
cord-018182-lleti89n	129	16	for	for	IN
cord-018182-lleti89n	129	17	10	10	CD
cord-018182-lleti89n	129	18	-	-	SYM
cord-018182-lleti89n	129	19	20	20	CD
cord-018182-lleti89n	129	20	seconds	second	NNS
cord-018182-lleti89n	129	21	should	should	MD
cord-018182-lleti89n	129	22	facilitate	facilitate	VB
cord-018182-lleti89n	129	23	a	a	DT
cord-018182-lleti89n	129	24	release	release	NN
cord-018182-lleti89n	129	25	of	of	IN
cord-018182-lleti89n	129	26	air	air	NN
cord-018182-lleti89n	129	27	from	from	IN
cord-018182-lleti89n	129	28	the	the	DT
cord-018182-lleti89n	129	29	patient	patient	NN
cord-018182-lleti89n	129	30	's	's	POS
cord-018182-lleti89n	129	31	pulmonary	pulmonary	JJ
cord-018182-lleti89n	129	32	tree	tree	NN
cord-018182-lleti89n	129	33	and	and	CC
cord-018182-lleti89n	129	34	improve	improve	VB
cord-018182-lleti89n	129	35	hemodynamics	hemodynamic	NNS
cord-018182-lleti89n	129	36	.	.	.
cord-018182-lleti89n	130	1	Auto	auto	NN
cord-018182-lleti89n	130	2	-	-	HYPH
cord-018182-lleti89n	130	3	PEEP	PEEP	NNP
cord-018182-lleti89n	130	4	can	can	MD
cord-018182-lleti89n	130	5	be	be	VB
cord-018182-lleti89n	130	6	monitored	monitor	VBN
cord-018182-lleti89n	130	7	on	on	IN
cord-018182-lleti89n	130	8	the	the	DT
cord-018182-lleti89n	130	9	ventilator	ventilator	NN
cord-018182-lleti89n	130	10	through	through	IN
cord-018182-lleti89n	130	11	the	the	DT
cord-018182-lleti89n	130	12	use	use	NN
cord-018182-lleti89n	130	13	of	of	IN
cord-018182-lleti89n	130	14	the	the	DT
cord-018182-lleti89n	130	15	end	end	NN
cord-018182-lleti89n	130	16	-	-	HYPH
cord-018182-lleti89n	130	17	expiratory	expiratory	NN
cord-018182-lleti89n	130	18	hold	hold	NN
cord-018182-lleti89n	130	19	maneuver	maneuver	NN
cord-018182-lleti89n	130	20	(	(	-LRB-
cord-018182-lleti89n	130	21	although	although	IN
cord-018182-lleti89n	130	22	accurate	accurate	JJ
cord-018182-lleti89n	130	23	measurements	measurement	NNS
cord-018182-lleti89n	130	24	require	require	VBP
cord-018182-lleti89n	130	25	that	that	IN
cord-018182-lleti89n	130	26	the	the	DT
cord-018182-lleti89n	130	27	patient	patient	NN
cord-018182-lleti89n	130	28	have	have	VBP
cord-018182-lleti89n	130	29	no	no	DT
cord-018182-lleti89n	130	30	active	active	JJ
cord-018182-lleti89n	130	31	respiratory	respiratory	JJ
cord-018182-lleti89n	130	32	effort	effort	NN
cord-018182-lleti89n	130	33	)	)	-RRB-
cord-018182-lleti89n	131	1	[	[	-LRB-
cord-018182-lleti89n	131	2	25	25	CD
cord-018182-lleti89n	131	3	]	]	-RRB-
cord-018182-lleti89n	131	4	.	.	.
cord-018182-lleti89n	132	1	Auto	auto	NN
cord-018182-lleti89n	132	2	-	-	HYPH
cord-018182-lleti89n	132	3	PEEP	PEEP	NNP
cord-018182-lleti89n	132	4	may	may	MD
cord-018182-lleti89n	132	5	also	also	RB
cord-018182-lleti89n	132	6	be	be	VB
cord-018182-lleti89n	132	7	identified	identify	VBN
cord-018182-lleti89n	132	8	by	by	IN
cord-018182-lleti89n	132	9	monitoring	monitor	VBG
cord-018182-lleti89n	132	10	the	the	DT
cord-018182-lleti89n	132	11	flow	flow	NN
cord-018182-lleti89n	132	12	-	-	HYPH
cord-018182-lleti89n	132	13	time	time	NN
cord-018182-lleti89n	132	14	trace	trace	NN
cord-018182-lleti89n	132	15	where	where	WRB
cord-018182-lleti89n	132	16	the	the	DT
cord-018182-lleti89n	132	17	exhilatory	exhilatory	JJ
cord-018182-lleti89n	132	18	trace	trace	NN
cord-018182-lleti89n	132	19	fails	fail	VBZ
cord-018182-lleti89n	132	20	to	to	TO
cord-018182-lleti89n	132	21	return	return	VB
cord-018182-lleti89n	132	22	to	to	IN
cord-018182-lleti89n	132	23	baseline	baseline	NN
cord-018182-lleti89n	132	24	prior	prior	RB
cord-018182-lleti89n	132	25	to	to	IN
cord-018182-lleti89n	132	26	the	the	DT
cord-018182-lleti89n	132	27	start	start	NN
cord-018182-lleti89n	132	28	of	of	IN
cord-018182-lleti89n	132	29	the	the	DT
cord-018182-lleti89n	132	30	next	next	JJ
cord-018182-lleti89n	132	31	breath	breath	NN
cord-018182-lleti89n	132	32	.	.	.
cord-018182-lleti89n	133	1	Significant	significant	JJ
cord-018182-lleti89n	133	2	auto	auto	NN
cord-018182-lleti89n	133	3	-	-	HYPH
cord-018182-lleti89n	133	4	PEEP	peep	NN
cord-018182-lleti89n	133	5	may	may	MD
cord-018182-lleti89n	133	6	be	be	VB
cord-018182-lleti89n	133	7	treated	treat	VBN
cord-018182-lleti89n	133	8	by	by	IN
cord-018182-lleti89n	133	9	careful	careful	JJ
cord-018182-lleti89n	133	10	ventilator	ventilator	NN
cord-018182-lleti89n	133	11	management	management	NN
cord-018182-lleti89n	133	12	aimed	aim	VBN
cord-018182-lleti89n	133	13	at	at	IN
cord-018182-lleti89n	133	14	increasing	increase	VBG
cord-018182-lleti89n	133	15	the	the	DT
cord-018182-lleti89n	133	16	expiratory	expiratory	JJ
cord-018182-lleti89n	133	17	time	time	NN
cord-018182-lleti89n	133	18	to	to	TO
cord-018182-lleti89n	133	19	allow	allow	VB
cord-018182-lleti89n	133	20	adequate	adequate	JJ
cord-018182-lleti89n	133	21	emptying	emptying	NN
cord-018182-lleti89n	133	22	of	of	IN
cord-018182-lleti89n	133	23	the	the	DT
cord-018182-lleti89n	133	24	lungs	lung	NNS
cord-018182-lleti89n	133	25	.	.	.
cord-018182-lleti89n	134	1	Maneuvers	maneuver	NNS
cord-018182-lleti89n	134	2	include	include	VBP
cord-018182-lleti89n	134	3	increasing	increase	VBG
cord-018182-lleti89n	134	4	the	the	DT
cord-018182-lleti89n	134	5	inspiratory	inspiratory	JJ
cord-018182-lleti89n	134	6	flow	flow	NN
cord-018182-lleti89n	134	7	rate	rate	NN
cord-018182-lleti89n	134	8	and	and	CC
cord-018182-lleti89n	134	9	decreasing	decrease	VBG
cord-018182-lleti89n	134	10	the	the	DT
cord-018182-lleti89n	134	11	respiratory	respiratory	JJ
cord-018182-lleti89n	134	12	rate	rate	NN
cord-018182-lleti89n	134	13	or	or	CC
cord-018182-lleti89n	134	14	tidal	tidal	JJ
cord-018182-lleti89n	134	15	volume	volume	NN
cord-018182-lleti89n	134	16	.	.	.
cord-018182-lleti89n	135	1	Other	other	JJ
cord-018182-lleti89n	135	2	methods	method	NNS
cord-018182-lleti89n	135	3	for	for	IN
cord-018182-lleti89n	135	4	minimizing	minimize	VBG
cord-018182-lleti89n	135	5	auto	auto	NN
cord-018182-lleti89n	135	6	-	-	HYPH
cord-018182-lleti89n	135	7	PEEP	peep	NN
cord-018182-lleti89n	135	8	include	include	VBP
cord-018182-lleti89n	135	9	reduction	reduction	NN
cord-018182-lleti89n	135	10	of	of	IN
cord-018182-lleti89n	135	11	spontaneous	spontaneous	JJ
cord-018182-lleti89n	135	12	ventilatory	ventilatory	JJ
cord-018182-lleti89n	135	13	demand	demand	NN
cord-018182-lleti89n	135	14	through	through	IN
cord-018182-lleti89n	135	15	the	the	DT
cord-018182-lleti89n	135	16	administration	administration	NN
cord-018182-lleti89n	135	17	of	of	IN
cord-018182-lleti89n	135	18	sedation	sedation	NN
cord-018182-lleti89n	135	19	,	,	,
cord-018182-lleti89n	135	20	analgesia	analgesia	NN
cord-018182-lleti89n	135	21	,	,	,
cord-018182-lleti89n	135	22	and	and	CC
cord-018182-lleti89n	135	23	occasionally	occasionally	RB
cord-018182-lleti89n	135	24	paralytics	paralytic	NNS
cord-018182-lleti89n	135	25	.	.	.
cord-018182-lleti89n	136	1	Similarly	similarly	RB
cord-018182-lleti89n	136	2	,	,	,
cord-018182-lleti89n	136	3	reducing	reduce	VBG
cord-018182-lleti89n	136	4	flow	flow	NN
cord-018182-lleti89n	136	5	resistance	resistance	NN
cord-018182-lleti89n	136	6	with	with	IN
cord-018182-lleti89n	136	7	larger	large	JJR
cord-018182-lleti89n	136	8	bore	bore	NN
cord-018182-lleti89n	136	9	endotracheal	endotracheal	NN
cord-018182-lleti89n	136	10	tubes	tube	NNS
cord-018182-lleti89n	136	11	,	,	,
cord-018182-lleti89n	136	12	frequent	frequent	JJ
cord-018182-lleti89n	136	13	suctioning	suctioning	NN
cord-018182-lleti89n	136	14	,	,	,
cord-018182-lleti89n	136	15	and	and	CC
cord-018182-lleti89n	136	16	bronchodilator	bronchodilator	NN
cord-018182-lleti89n	136	17	administration	administration	NN
cord-018182-lleti89n	136	18	may	may	MD
cord-018182-lleti89n	136	19	also	also	RB
cord-018182-lleti89n	136	20	reduce	reduce	VB
cord-018182-lleti89n	136	21	auto	auto	NN
cord-018182-lleti89n	136	22	-	-	HYPH
cord-018182-lleti89n	136	23	PEEP	peep	NN
cord-018182-lleti89n	136	24	by	by	IN
cord-018182-lleti89n	136	25	reducing	reduce	VBG
cord-018182-lleti89n	136	26	resistance	resistance	NN
cord-018182-lleti89n	136	27	to	to	IN
cord-018182-lleti89n	136	28	gas	gas	NN
cord-018182-lleti89n	136	29	flow	flow	NN
cord-018182-lleti89n	136	30	.	.	.
cord-018182-lleti89n	137	1	Expiratory	Expiratory	NNP
cord-018182-lleti89n	137	2	flow	flow	NN
cord-018182-lleti89n	137	3	limitation	limitation	NN
cord-018182-lleti89n	137	4	can	can	MD
cord-018182-lleti89n	137	5	also	also	RB
cord-018182-lleti89n	137	6	be	be	VB
cord-018182-lleti89n	137	7	counterbalanced	counterbalance	VBN
cord-018182-lleti89n	137	8	with	with	IN
cord-018182-lleti89n	137	9	the	the	DT
cord-018182-lleti89n	137	10	application	application	NN
cord-018182-lleti89n	137	11	of	of	IN
cord-018182-lleti89n	137	12	applied	apply	VBN
cord-018182-lleti89n	137	13	(	(	-LRB-
cord-018182-lleti89n	137	14	external	external	JJ
cord-018182-lleti89n	137	15	)	)	-RRB-
cord-018182-lleti89n	137	16	PEEP	peep	NN
cord-018182-lleti89n	137	17	to	to	TO
cord-018182-lleti89n	137	18	match	match	VB
cord-018182-lleti89n	137	19	the	the	DT
cord-018182-lleti89n	137	20	intrinsic	intrinsic	JJ
cord-018182-lleti89n	137	21	(	(	-LRB-
cord-018182-lleti89n	137	22	auto	auto	NN
cord-018182-lleti89n	137	23	)	)	-RRB-
cord-018182-lleti89n	137	24	PEEP	PEEP	NNP
cord-018182-lleti89n	137	25	[	[	-LRB-
cord-018182-lleti89n	137	26	25	25	CD
cord-018182-lleti89n	137	27	]	]	-RRB-
cord-018182-lleti89n	137	28	.	.	.
cord-018182-lleti89n	138	1	Patients	patient	NNS
cord-018182-lleti89n	138	2	with	with	IN
cord-018182-lleti89n	138	3	severe	severe	JJ
cord-018182-lleti89n	138	4	underlying	underlie	VBG
cord-018182-lleti89n	138	5	COPD	COPD	NNP
cord-018182-lleti89n	138	6	and	and	CC
cord-018182-lleti89n	138	7	exacerbations	exacerbation	NNS
cord-018182-lleti89n	138	8	with	with	IN
cord-018182-lleti89n	138	9	resultant	resultant	JJ
cord-018182-lleti89n	138	10	respiratory	respiratory	JJ
cord-018182-lleti89n	138	11	failure	failure	NN
cord-018182-lleti89n	138	12	may	may	MD
cord-018182-lleti89n	138	13	experience	experience	VB
cord-018182-lleti89n	138	14	difficulty	difficulty	NN
cord-018182-lleti89n	138	15	weaning	wean	VBG
cord-018182-lleti89n	138	16	from	from	IN
cord-018182-lleti89n	138	17	the	the	DT
cord-018182-lleti89n	138	18	ventilator	ventilator	NN
cord-018182-lleti89n	138	19	.	.	.
cord-018182-lleti89n	139	1	Goals	goal	NNS
cord-018182-lleti89n	139	2	of	of	IN
cord-018182-lleti89n	139	3	care	care	NN
cord-018182-lleti89n	139	4	discussions	discussion	NNS
cord-018182-lleti89n	139	5	regarding	regard	VBG
cord-018182-lleti89n	139	6	tracheostomy	tracheostomy	NN
cord-018182-lleti89n	139	7	,	,	,
cord-018182-lleti89n	139	8	possible	possible	JJ
cord-018182-lleti89n	139	9	chronic	chronic	JJ
cord-018182-lleti89n	139	10	mechanical	mechanical	JJ
cord-018182-lleti89n	139	11	ventilation	ventilation	NN
cord-018182-lleti89n	139	12	needs	need	NNS
cord-018182-lleti89n	139	13	,	,	,
cord-018182-lleti89n	139	14	and	and	CC
cord-018182-lleti89n	139	15	advanced	advanced	JJ
cord-018182-lleti89n	139	16	care	care	NN
cord-018182-lleti89n	139	17	planning	planning	NN
cord-018182-lleti89n	139	18	may	may	MD
cord-018182-lleti89n	139	19	be	be	VB
cord-018182-lleti89n	139	20	necessary	necessary	JJ
cord-018182-lleti89n	139	21	;	;	:
cord-018182-lleti89n	139	22	palliative	palliative	JJ
cord-018182-lleti89n	139	23	care	care	NN
cord-018182-lleti89n	139	24	consultation	consultation	NN
cord-018182-lleti89n	139	25	may	may	MD
cord-018182-lleti89n	139	26	be	be	VB
cord-018182-lleti89n	139	27	invaluable	invaluable	JJ
cord-018182-lleti89n	139	28	in	in	IN
cord-018182-lleti89n	139	29	this	this	DT
cord-018182-lleti89n	139	30	process	process	NN
cord-018182-lleti89n	139	31	.	.	.
cord-018182-lleti89n	140	1	In	in	IN
cord-018182-lleti89n	140	2	general	general	JJ
cord-018182-lleti89n	140	3	,	,	,
cord-018182-lleti89n	140	4	patients	patient	NNS
cord-018182-lleti89n	140	5	with	with	IN
cord-018182-lleti89n	140	6	failure	failure	NN
cord-018182-lleti89n	140	7	to	to	TO
cord-018182-lleti89n	140	8	progress	progress	VB
cord-018182-lleti89n	140	9	in	in	IN
cord-018182-lleti89n	140	10	weaning	wean	VBG
cord-018182-lleti89n	140	11	toward	toward	IN
cord-018182-lleti89n	140	12	possible	possible	JJ
cord-018182-lleti89n	140	13	extubation	extubation	NN
cord-018182-lleti89n	140	14	by	by	IN
cord-018182-lleti89n	140	15	the	the	DT
cord-018182-lleti89n	140	16	end	end	NN
cord-018182-lleti89n	140	17	of	of	IN
cord-018182-lleti89n	140	18	the	the	DT
cord-018182-lleti89n	140	19	second	second	JJ
cord-018182-lleti89n	140	20	week	week	NN
cord-018182-lleti89n	140	21	of	of	IN
cord-018182-lleti89n	140	22	mechanical	mechanical	JJ
cord-018182-lleti89n	140	23	ventilation	ventilation	NN
cord-018182-lleti89n	140	24	should	should	MD
cord-018182-lleti89n	140	25	be	be	VB
cord-018182-lleti89n	140	26	considered	consider	VBN
cord-018182-lleti89n	140	27	for	for	IN
cord-018182-lleti89n	140	28	tracheostomy	tracheostomy	NN
cord-018182-lleti89n	140	29	as	as	IN
cord-018182-lleti89n	140	30	prolonged	prolong	VBN
cord-018182-lleti89n	140	31	endotracheal	endotracheal	NN
cord-018182-lleti89n	140	32	intubation	intubation	NN
cord-018182-lleti89n	140	33	can	can	MD
cord-018182-lleti89n	140	34	result	result	VB
cord-018182-lleti89n	140	35	in	in	IN
cord-018182-lleti89n	140	36	upper	upper	JJ
cord-018182-lleti89n	140	37	airway	airway	NN
cord-018182-lleti89n	140	38	injury	injury	NN
cord-018182-lleti89n	140	39	.	.	.
cord-018182-lleti89n	141	1	In	in	IN
cord-018182-lleti89n	141	2	patients	patient	NNS
cord-018182-lleti89n	141	3	with	with	IN
cord-018182-lleti89n	141	4	advanced	advanced	JJ
cord-018182-lleti89n	141	5	COPD	COPD	NNP
cord-018182-lleti89n	141	6	,	,	,
cord-018182-lleti89n	141	7	weaning	wean	VBG
cord-018182-lleti89n	141	8	from	from	IN
cord-018182-lleti89n	141	9	mechanical	mechanical	JJ
cord-018182-lleti89n	141	10	ventilation	ventilation	NN
cord-018182-lleti89n	141	11	may	may	MD
cord-018182-lleti89n	141	12	require	require	VB
cord-018182-lleti89n	141	13	several	several	JJ
cord-018182-lleti89n	141	14	weeks	week	NNS
cord-018182-lleti89n	141	15	.	.	.
cord-018182-lleti89n	142	1	Strategies	strategy	NNS
cord-018182-lleti89n	142	2	for	for	IN
cord-018182-lleti89n	142	3	ventilator	ventilator	NN
cord-018182-lleti89n	142	4	weaning	wean	VBG
cord-018182-lleti89n	142	5	vary	vary	VBP
cord-018182-lleti89n	142	6	but	but	CC
cord-018182-lleti89n	142	7	typically	typically	RB
cord-018182-lleti89n	142	8	consist	consist	VBP
cord-018182-lleti89n	142	9	of	of	IN
cord-018182-lleti89n	142	10	steadily	steadily	RB
cord-018182-lleti89n	142	11	increasing	increase	VBG
cord-018182-lleti89n	142	12	time	time	NN
cord-018182-lleti89n	142	13	on	on	IN
cord-018182-lleti89n	142	14	pressure	pressure	NN
cord-018182-lleti89n	142	15	support	support	NN
cord-018182-lleti89n	142	16	trials	trial	NNS
cord-018182-lleti89n	142	17	admixed	admix	VBN
cord-018182-lleti89n	142	18	with	with	IN
cord-018182-lleti89n	142	19	periods	period	NNS
cord-018182-lleti89n	142	20	of	of	IN
cord-018182-lleti89n	142	21	assist	assist	VB
cord-018182-lleti89n	142	22	-	-	HYPH
cord-018182-lleti89n	142	23	control	control	NN
cord-018182-lleti89n	142	24	volume	volume	NN
cord-018182-lleti89n	142	25	-	-	HYPH
cord-018182-lleti89n	142	26	cycled	cycle	VBN
cord-018182-lleti89n	142	27	ventilation	ventilation	NN
cord-018182-lleti89n	142	28	for	for	IN
cord-018182-lleti89n	142	29	rest	rest	NN
cord-018182-lleti89n	142	30	.	.	.
cord-018182-lleti89n	143	1	The	the	DT
cord-018182-lleti89n	143	2	weaning	weaning	NN
cord-018182-lleti89n	143	3	process	process	NN
cord-018182-lleti89n	143	4	may	may	MD
cord-018182-lleti89n	143	5	be	be	VB
cord-018182-lleti89n	143	6	augmented	augment	VBN
cord-018182-lleti89n	143	7	by	by	IN
cord-018182-lleti89n	143	8	tracheostomy	tracheostomy	NN
cord-018182-lleti89n	143	9	placement	placement	NN
cord-018182-lleti89n	143	10	given	give	VBN
cord-018182-lleti89n	143	11	the	the	DT
cord-018182-lleti89n	143	12	ability	ability	NN
cord-018182-lleti89n	143	13	to	to	TO
cord-018182-lleti89n	143	14	perform	perform	VB
cord-018182-lleti89n	143	15	tracheostomy	tracheostomy	NN
cord-018182-lleti89n	143	16	collar	collar	NN
cord-018182-lleti89n	143	17	trials	trial	NNS
cord-018182-lleti89n	143	18	with	with	IN
cord-018182-lleti89n	143	19	intermittent	intermittent	JJ
cord-018182-lleti89n	143	20	ventilator	ventilator	NN
cord-018182-lleti89n	143	21	support	support	NN
cord-018182-lleti89n	143	22	rather	rather	RB
cord-018182-lleti89n	143	23	than	than	IN
cord-018182-lleti89n	143	24	proceeding	proceed	VBG
cord-018182-lleti89n	143	25	directly	directly	RB
cord-018182-lleti89n	143	26	to	to	IN
cord-018182-lleti89n	143	27	extubation	extubation	NN
cord-018182-lleti89n	143	28	and	and	CC
cord-018182-lleti89n	143	29	independent	independent	JJ
cord-018182-lleti89n	143	30	ventilation	ventilation	NN
cord-018182-lleti89n	143	31	.	.	.
cord-018182-lleti89n	144	1	Tracheostomy	tracheostomy	NN
cord-018182-lleti89n	144	2	is	be	VBZ
cord-018182-lleti89n	144	3	also	also	RB
cord-018182-lleti89n	144	4	generally	generally	RB
cord-018182-lleti89n	144	5	more	more	RBR
cord-018182-lleti89n	144	6	comfortable	comfortable	JJ
cord-018182-lleti89n	144	7	for	for	IN
cord-018182-lleti89n	144	8	patients	patient	NNS
cord-018182-lleti89n	144	9	,	,	,
cord-018182-lleti89n	144	10	thereby	thereby	RB
cord-018182-lleti89n	144	11	reducing	reduce	VBG
cord-018182-lleti89n	144	12	sedation	sedation	NN
cord-018182-lleti89n	144	13	and	and	CC
cord-018182-lleti89n	144	14	analgesia	analgesia	NN
cord-018182-lleti89n	144	15	needs	need	VBZ
cord-018182-lleti89n	144	16	that	that	WDT
cord-018182-lleti89n	144	17	may	may	MD
cord-018182-lleti89n	144	18	accelerate	accelerate	VB
cord-018182-lleti89n	144	19	weaning	wean	VBG
cord-018182-lleti89n	144	20	.	.	.
cord-018182-lleti89n	145	1	NPPV	NPPV	NNP
cord-018182-lleti89n	145	2	may	may	MD
cord-018182-lleti89n	145	3	also	also	RB
cord-018182-lleti89n	145	4	be	be	VB
cord-018182-lleti89n	145	5	an	an	DT
cord-018182-lleti89n	145	6	important	important	JJ
cord-018182-lleti89n	145	7	salvage	salvage	NN
cord-018182-lleti89n	145	8	mode	mode	NN
cord-018182-lleti89n	145	9	of	of	IN
cord-018182-lleti89n	145	10	ventilation	ventilation	NN
cord-018182-lleti89n	145	11	for	for	IN
cord-018182-lleti89n	145	12	patients	patient	NNS
cord-018182-lleti89n	145	13	who	who	WP
cord-018182-lleti89n	145	14	initially	initially	RB
cord-018182-lleti89n	145	15	fail	fail	VBP
cord-018182-lleti89n	145	16	extubation	extubation	NN
cord-018182-lleti89n	145	17	and	and	CC
cord-018182-lleti89n	145	18	only	only	RB
cord-018182-lleti89n	145	19	require	require	VB
cord-018182-lleti89n	145	20	intermittent	intermittent	JJ
cord-018182-lleti89n	145	21	ventilatory	ventilatory	JJ
cord-018182-lleti89n	145	22	support	support	NN
cord-018182-lleti89n	145	23	.	.	.
cord-018182-lleti89n	146	1	Clinical	clinical	JJ
cord-018182-lleti89n	146	2	decision	decision	NN
cord-018182-lleti89n	146	3	-	-	HYPH
cord-018182-lleti89n	146	4	making	make	VBG
cord-018182-lleti89n	146	5	regarding	regard	VBG
cord-018182-lleti89n	146	6	tracheostomy	tracheostomy	NN
cord-018182-lleti89n	146	7	versus	versus	IN
cord-018182-lleti89n	146	8	palliative	palliative	JJ
cord-018182-lleti89n	146	9	extubation	extubation	NN
cord-018182-lleti89n	146	10	should	should	MD
cord-018182-lleti89n	146	11	be	be	VB
cord-018182-lleti89n	146	12	based	base	VBN
cord-018182-lleti89n	146	13	on	on	IN
cord-018182-lleti89n	146	14	individual	individual	JJ
cord-018182-lleti89n	146	15	patient	patient	NN
cord-018182-lleti89n	146	16	and	and	CC
cord-018182-lleti89n	146	17	family	family	NN
cord-018182-lleti89n	146	18	preferences	preference	NNS
cord-018182-lleti89n	146	19	.	.	.
cord-018182-lleti89n	147	1	Prognostication	prognostication	NN
cord-018182-lleti89n	147	2	in	in	IN
cord-018182-lleti89n	147	3	this	this	DT
cord-018182-lleti89n	147	4	patient	patient	JJ
cord-018182-lleti89n	147	5	population	population	NN
cord-018182-lleti89n	147	6	is	be	VBZ
cord-018182-lleti89n	147	7	often	often	RB
cord-018182-lleti89n	147	8	challenging	challenging	JJ
cord-018182-lleti89n	147	9	and	and	CC
cord-018182-lleti89n	147	10	complex	complex	JJ
cord-018182-lleti89n	147	11	but	but	CC
cord-018182-lleti89n	147	12	early	early	JJ
cord-018182-lleti89n	147	13	involvement	involvement	NN
cord-018182-lleti89n	147	14	of	of	IN
cord-018182-lleti89n	147	15	palliative	palliative	JJ
cord-018182-lleti89n	147	16	care	care	NN
cord-018182-lleti89n	147	17	consultants	consultant	NNS
cord-018182-lleti89n	147	18	,	,	,
cord-018182-lleti89n	147	19	where	where	WRB
cord-018182-lleti89n	147	20	available	available	JJ
cord-018182-lleti89n	147	21	,	,	,
cord-018182-lleti89n	147	22	is	be	VBZ
cord-018182-lleti89n	147	23	recommended	recommend	VBN
cord-018182-lleti89n	147	24	.	.	.
cord-018182-lleti89n	148	1	An	an	DT
cord-018182-lleti89n	148	2	episode	episode	NN
cord-018182-lleti89n	148	3	of	of	IN
cord-018182-lleti89n	148	4	respiratory	respiratory	JJ
cord-018182-lleti89n	148	5	failure	failure	NN
cord-018182-lleti89n	148	6	should	should	MD
cord-018182-lleti89n	148	7	prompt	prompt	VB
cord-018182-lleti89n	148	8	discussions	discussion	NNS
cord-018182-lleti89n	148	9	of	of	IN
cord-018182-lleti89n	148	10	patient	patient	JJ
cord-018182-lleti89n	148	11	care	care	NN
cord-018182-lleti89n	148	12	goals	goal	NNS
cord-018182-lleti89n	148	13	and	and	CC
cord-018182-lleti89n	148	14	values	value	NNS
cord-018182-lleti89n	148	15	for	for	IN
cord-018182-lleti89n	148	16	both	both	CC
cord-018182-lleti89n	148	17	short	short	JJ
cord-018182-lleti89n	148	18	-	-	HYPH
cord-018182-lleti89n	148	19	and	and	CC
cord-018182-lleti89n	148	20	long	long	JJ
cord-018182-lleti89n	148	21	-	-	HYPH
cord-018182-lleti89n	148	22	term	term	NN
cord-018182-lleti89n	148	23	advanced	advanced	JJ
cord-018182-lleti89n	148	24	care	care	NN
cord-018182-lleti89n	148	25	planning	planning	NN
cord-018182-lleti89n	148	26	.	.	.
cord-018182-lleti89n	149	1	When	when	WRB
cord-018182-lleti89n	149	2	appropriate	appropriate	JJ
cord-018182-lleti89n	149	3	,	,	,
cord-018182-lleti89n	149	4	formal	formal	JJ
cord-018182-lleti89n	149	5	hospice	hospice	NN
cord-018182-lleti89n	149	6	referrals	referral	NNS
cord-018182-lleti89n	149	7	should	should	MD
cord-018182-lleti89n	149	8	be	be	VB
cord-018182-lleti89n	149	9	considered	consider	VBN
cord-018182-lleti89n	149	10	.	.	.
cord-018182-lleti89n	150	1	In	in	IN
cord-018182-lleti89n	150	2	all	all	DT
cord-018182-lleti89n	150	3	cases	case	NNS
cord-018182-lleti89n	150	4	,	,	,
cord-018182-lleti89n	150	5	sufficient	sufficient	JJ
cord-018182-lleti89n	150	6	treatment	treatment	NN
cord-018182-lleti89n	150	7	of	of	IN
cord-018182-lleti89n	150	8	dyspnea	dyspnea	NN
cord-018182-lleti89n	150	9	and	and	CC
cord-018182-lleti89n	150	10	pain	pain	NN
cord-018182-lleti89n	150	11	should	should	MD
cord-018182-lleti89n	150	12	be	be	VB
cord-018182-lleti89n	150	13	provided	provide	VBN
cord-018182-lleti89n	150	14	.	.	.
cord-018182-lleti89n	151	1	Pulmonary	pulmonary	JJ
cord-018182-lleti89n	151	2	hypertension	hypertension	NN
cord-018182-lleti89n	151	3	(	(	-LRB-
cord-018182-lleti89n	151	4	PH	PH	NNP
cord-018182-lleti89n	151	5	)	)	-RRB-
cord-018182-lleti89n	151	6	refers	refer	VBZ
cord-018182-lleti89n	151	7	to	to	IN
cord-018182-lleti89n	151	8	a	a	DT
cord-018182-lleti89n	151	9	complex	complex	JJ
cord-018182-lleti89n	151	10	group	group	NN
cord-018182-lleti89n	151	11	of	of	IN
cord-018182-lleti89n	151	12	clinical	clinical	JJ
cord-018182-lleti89n	151	13	conditions	condition	NNS
cord-018182-lleti89n	151	14	defined	define	VBN
cord-018182-lleti89n	151	15	by	by	IN
cord-018182-lleti89n	151	16	abnormal	abnormal	JJ
cord-018182-lleti89n	151	17	elevation	elevation	NN
cord-018182-lleti89n	151	18	of	of	IN
cord-018182-lleti89n	151	19	blood	blood	NN
cord-018182-lleti89n	151	20	pressure	pressure	NN
cord-018182-lleti89n	151	21	in	in	IN
cord-018182-lleti89n	151	22	the	the	DT
cord-018182-lleti89n	151	23	pulmonary	pulmonary	JJ
cord-018182-lleti89n	151	24	circulation	circulation	NN
cord-018182-lleti89n	151	25	.	.	.
cord-018182-lleti89n	152	1	It	-PRON-	PRP
cord-018182-lleti89n	152	2	is	be	VBZ
cord-018182-lleti89n	152	3	further	further	RB
cord-018182-lleti89n	152	4	defined	define	VBN
cord-018182-lleti89n	152	5	as	as	IN
cord-018182-lleti89n	152	6	a	a	DT
cord-018182-lleti89n	152	7	mean	mean	JJ
cord-018182-lleti89n	152	8	pulmonary	pulmonary	JJ
cord-018182-lleti89n	152	9	arterial	arterial	JJ
cord-018182-lleti89n	152	10	pressure	pressure	NN
cord-018182-lleti89n	152	11	(	(	-LRB-
cord-018182-lleti89n	152	12	mPAP	mpap	NN
cord-018182-lleti89n	152	13	)	)	-RRB-
cord-018182-lleti89n	152	14	of	of	IN
cord-018182-lleti89n	152	15	≥25	≥25	NNP
cord-018182-lleti89n	152	16	mmHg	mmHg	NNPS
cord-018182-lleti89n	152	17	at	at	IN
cord-018182-lleti89n	152	18	rest	rest	NN
cord-018182-lleti89n	152	19	on	on	IN
cord-018182-lleti89n	152	20	right	right	JJ
cord-018182-lleti89n	152	21	heart	heart	NN
cord-018182-lleti89n	152	22	catheterization	catheterization	NN
cord-018182-lleti89n	152	23	(	(	-LRB-
cord-018182-lleti89n	152	24	RHC	RHC	NNP
cord-018182-lleti89n	152	25	)	)	-RRB-
cord-018182-lleti89n	152	26	[	[	-LRB-
cord-018182-lleti89n	152	27	26	26	CD
cord-018182-lleti89n	152	28	]	]	-RRB-
cord-018182-lleti89n	152	29	.	.	.
cord-018182-lleti89n	153	1	Typically	typically	RB
cord-018182-lleti89n	153	2	PH	PH	NNP
cord-018182-lleti89n	153	3	is	be	VBZ
cord-018182-lleti89n	153	4	discussed	discuss	VBN
cord-018182-lleti89n	153	5	in	in	IN
cord-018182-lleti89n	153	6	the	the	DT
cord-018182-lleti89n	153	7	context	context	NN
cord-018182-lleti89n	153	8	of	of	IN
cord-018182-lleti89n	153	9	true	true	JJ
cord-018182-lleti89n	153	10	pulmonary	pulmonary	JJ
cord-018182-lleti89n	153	11	arterial	arterial	JJ
cord-018182-lleti89n	153	12	hypertension	hypertension	NN
cord-018182-lleti89n	153	13	(	(	-LRB-
cord-018182-lleti89n	153	14	PAH	PAH	NNP
cord-018182-lleti89n	153	15	)	)	-RRB-
cord-018182-lleti89n	153	16	resulting	result	VBG
cord-018182-lleti89n	153	17	from	from	IN
cord-018182-lleti89n	153	18	pressure	pressure	NN
cord-018182-lleti89n	153	19	elevations	elevation	NNS
cord-018182-lleti89n	153	20	in	in	IN
cord-018182-lleti89n	153	21	the	the	DT
cord-018182-lleti89n	153	22	pulmonary	pulmonary	JJ
cord-018182-lleti89n	153	23	arterial	arterial	JJ
cord-018182-lleti89n	153	24	system	system	NN
cord-018182-lleti89n	153	25	or	or	CC
cord-018182-lleti89n	153	26	pulmonary	pulmonary	JJ
cord-018182-lleti89n	153	27	venous	venous	JJ
cord-018182-lleti89n	153	28	hypertension	hypertension	NN
cord-018182-lleti89n	153	29	(	(	-LRB-
cord-018182-lleti89n	153	30	PVH	PVH	NNP
cord-018182-lleti89n	153	31	)	)	-RRB-
cord-018182-lleti89n	153	32	occurring	occur	VBG
cord-018182-lleti89n	153	33	secondary	secondary	JJ
cord-018182-lleti89n	153	34	to	to	TO
cord-018182-lleti89n	153	35	pressure	pressure	VB
cord-018182-lleti89n	153	36	elevations	elevation	NNS
cord-018182-lleti89n	153	37	in	in	IN
cord-018182-lleti89n	153	38	the	the	DT
cord-018182-lleti89n	153	39	pulmonary	pulmonary	JJ
cord-018182-lleti89n	153	40	venous	venous	JJ
cord-018182-lleti89n	153	41	and	and	CC
cord-018182-lleti89n	153	42	capillary	capillary	JJ
cord-018182-lleti89n	153	43	systems	system	NNS
cord-018182-lleti89n	153	44	.	.	.
cord-018182-lleti89n	154	1	PVH	PVH	NNP
cord-018182-lleti89n	154	2	is	be	VBZ
cord-018182-lleti89n	154	3	typically	typically	RB
cord-018182-lleti89n	154	4	seen	see	VBN
cord-018182-lleti89n	154	5	in	in	IN
cord-018182-lleti89n	154	6	the	the	DT
cord-018182-lleti89n	154	7	setting	setting	NN
cord-018182-lleti89n	154	8	of	of	IN
cord-018182-lleti89n	154	9	elevated	elevated	JJ
cord-018182-lleti89n	154	10	pulmonary	pulmonary	JJ
cord-018182-lleti89n	154	11	artery	artery	NN
cord-018182-lleti89n	154	12	occlusion	occlusion	NN
cord-018182-lleti89n	154	13	pressures	pressure	NNS
cord-018182-lleti89n	154	14	(	(	-LRB-
cord-018182-lleti89n	154	15	PAOP	PAOP	NNP
cord-018182-lleti89n	154	16	)	)	-RRB-
cord-018182-lleti89n	154	17	resulting	result	VBG
cord-018182-lleti89n	154	18	from	from	IN
cord-018182-lleti89n	154	19	volume	volume	NN
cord-018182-lleti89n	154	20	overload	overload	NN
cord-018182-lleti89n	154	21	in	in	IN
cord-018182-lleti89n	154	22	left	left	JJ
cord-018182-lleti89n	154	23	ventricular	ventricular	JJ
cord-018182-lleti89n	154	24	(	(	-LRB-
cord-018182-lleti89n	154	25	LV	LV	NNP
cord-018182-lleti89n	154	26	)	)	-RRB-
cord-018182-lleti89n	154	27	failure	failure	NN
cord-018182-lleti89n	154	28	.	.	.
cord-018182-lleti89n	155	1	This	this	DT
cord-018182-lleti89n	155	2	distinction	distinction	NN
cord-018182-lleti89n	155	3	becomes	become	VBZ
cord-018182-lleti89n	155	4	important	important	JJ
cord-018182-lleti89n	155	5	in	in	IN
cord-018182-lleti89n	155	6	understanding	understand	VBG
cord-018182-lleti89n	155	7	the	the	DT
cord-018182-lleti89n	155	8	pathophysiology	pathophysiology	NN
cord-018182-lleti89n	155	9	of	of	IN
cord-018182-lleti89n	155	10	the	the	DT
cord-018182-lleti89n	155	11	disease	disease	NN
cord-018182-lleti89n	155	12	and	and	CC
cord-018182-lleti89n	155	13	in	in	IN
cord-018182-lleti89n	155	14	treatment	treatment	NN
cord-018182-lleti89n	155	15	decisions	decision	NNS
cord-018182-lleti89n	155	16	.	.	.
cord-018182-lleti89n	156	1	The	the	DT
cord-018182-lleti89n	156	2	World	World	NNP
cord-018182-lleti89n	156	3	Symposium	Symposium	NNP
cord-018182-lleti89n	156	4	on	on	IN
cord-018182-lleti89n	156	5	Pulmonary	Pulmonary	NNP
cord-018182-lleti89n	156	6	Hypertension	Hypertension	NNP
cord-018182-lleti89n	156	7	updated	update	VBD
cord-018182-lleti89n	156	8	its	-PRON-	PRP$
cord-018182-lleti89n	156	9	classification	classification	NN
cord-018182-lleti89n	156	10	in	in	IN
cord-018182-lleti89n	156	11	2013	2013	CD
cord-018182-lleti89n	156	12	to	to	TO
cord-018182-lleti89n	156	13	incorporate	incorporate	VB
cord-018182-lleti89n	156	14	five	five	CD
cord-018182-lleti89n	156	15	groups	group	NNS
cord-018182-lleti89n	156	16	of	of	IN
cord-018182-lleti89n	156	17	disorders	disorder	NNS
cord-018182-lleti89n	156	18	(	(	-LRB-
cord-018182-lleti89n	156	19	Table	table	NN
cord-018182-lleti89n	156	20	13	13	CD
cord-018182-lleti89n	156	21	.7	.7	NFP
cord-018182-lleti89n	156	22	)	)	-RRB-
cord-018182-lleti89n	157	1	[	[	-LRB-
cord-018182-lleti89n	157	2	27	27	CD
cord-018182-lleti89n	157	3	]	]	-RRB-
cord-018182-lleti89n	157	4	.	.	.
cord-018182-lleti89n	158	1	The	the	DT
cord-018182-lleti89n	158	2	diagnostic	diagnostic	JJ
cord-018182-lleti89n	158	3	evaluation	evaluation	NN
cord-018182-lleti89n	158	4	and	and	CC
cord-018182-lleti89n	158	5	treatment	treatment	NN
cord-018182-lleti89n	158	6	of	of	IN
cord-018182-lleti89n	158	7	PH	PH	NNP
cord-018182-lleti89n	158	8	in	in	IN
cord-018182-lleti89n	158	9	the	the	DT
cord-018182-lleti89n	158	10	clinically	clinically	RB
cord-018182-lleti89n	158	11	stable	stable	JJ
cord-018182-lleti89n	158	12	patient	patient	NN
cord-018182-lleti89n	158	13	is	be	VBZ
cord-018182-lleti89n	158	14	a	a	DT
cord-018182-lleti89n	158	15	separate	separate	JJ
cord-018182-lleti89n	158	16	topic	topic	NN
cord-018182-lleti89n	158	17	and	and	CC
cord-018182-lleti89n	158	18	will	will	MD
cord-018182-lleti89n	158	19	not	not	RB
cord-018182-lleti89n	158	20	be	be	VB
cord-018182-lleti89n	158	21	addressed	address	VBN
cord-018182-lleti89n	158	22	here	here	RB
cord-018182-lleti89n	158	23	.	.	.
cord-018182-lleti89n	159	1	Rather	rather	RB
cord-018182-lleti89n	159	2	,	,	,
cord-018182-lleti89n	159	3	the	the	DT
cord-018182-lleti89n	159	4	focus	focus	NN
cord-018182-lleti89n	159	5	of	of	IN
cord-018182-lleti89n	159	6	this	this	DT
cord-018182-lleti89n	159	7	discussion	discussion	NN
cord-018182-lleti89n	159	8	will	will	MD
cord-018182-lleti89n	159	9	be	be	VB
cord-018182-lleti89n	159	10	on	on	IN
cord-018182-lleti89n	159	11	the	the	DT
cord-018182-lleti89n	159	12	pathophysiology	pathophysiology	NN
cord-018182-lleti89n	159	13	,	,	,
cord-018182-lleti89n	159	14	diagnostic	diagnostic	JJ
cord-018182-lleti89n	159	15	evaluation	evaluation	NN
cord-018182-lleti89n	159	16	,	,	,
cord-018182-lleti89n	159	17	and	and	CC
cord-018182-lleti89n	159	18	treatment	treatment	NN
cord-018182-lleti89n	159	19	of	of	IN
cord-018182-lleti89n	159	20	PH	PH	NNP
cord-018182-lleti89n	159	21	and	and	CC
cord-018182-lleti89n	159	22	resulting	result	VBG
cord-018182-lleti89n	159	23	right	right	JJ
cord-018182-lleti89n	159	24	ventricular	ventricular	JJ
cord-018182-lleti89n	159	25	failure	failure	NN
cord-018182-lleti89n	159	26	(	(	-LRB-
cord-018182-lleti89n	159	27	RVF	RVF	NNP
cord-018182-lleti89n	159	28	)	)	-RRB-
cord-018182-lleti89n	159	29	as	as	IN
cord-018182-lleti89n	159	30	this	this	DT
cord-018182-lleti89n	159	31	is	be	VBZ
cord-018182-lleti89n	159	32	most	most	RBS
cord-018182-lleti89n	159	33	commonly	commonly	RB
cord-018182-lleti89n	159	34	observed	observe	VBN
cord-018182-lleti89n	159	35	in	in	IN
cord-018182-lleti89n	159	36	the	the	DT
cord-018182-lleti89n	159	37	intensive	intensive	JJ
cord-018182-lleti89n	159	38	care	care	NN
cord-018182-lleti89n	159	39	unit	unit	NN
cord-018182-lleti89n	159	40	(	(	-LRB-
cord-018182-lleti89n	159	41	ICU	ICU	NNP
cord-018182-lleti89n	159	42	)	)	-RRB-
cord-018182-lleti89n	159	43	setting	setting	NN
cord-018182-lleti89n	159	44	.	.	.
cord-018182-lleti89n	160	1	Pulmonary	pulmonary	JJ
cord-018182-lleti89n	160	2	hypertension	hypertension	NN
cord-018182-lleti89n	160	3	results	result	NNS
cord-018182-lleti89n	160	4	from	from	IN
cord-018182-lleti89n	160	5	increases	increase	NNS
cord-018182-lleti89n	160	6	in	in	IN
cord-018182-lleti89n	160	7	pulmonary	pulmonary	JJ
cord-018182-lleti89n	160	8	vascular	vascular	JJ
cord-018182-lleti89n	160	9	resistance	resistance	NN
cord-018182-lleti89n	160	10	(	(	-LRB-
cord-018182-lleti89n	160	11	PVR	PVR	NNP
cord-018182-lleti89n	160	12	)	)	-RRB-
cord-018182-lleti89n	160	13	present	present	JJ
cord-018182-lleti89n	160	14	in	in	IN
cord-018182-lleti89n	160	15	both	both	DT
cord-018182-lleti89n	160	16	acute	acute	JJ
cord-018182-lleti89n	160	17	and	and	CC
cord-018182-lleti89n	160	18	chronic	chronic	JJ
cord-018182-lleti89n	160	19	PH	PH	NNP
cord-018182-lleti89n	160	20	.	.	.
cord-018182-lleti89n	161	1	Rising	rise	VBG
cord-018182-lleti89n	161	2	pulmonary	pulmonary	JJ
cord-018182-lleti89n	161	3	pressures	pressure	NNS
cord-018182-lleti89n	161	4	create	create	VBP
cord-018182-lleti89n	161	5	increases	increase	NNS
cord-018182-lleti89n	161	6	in	in	IN
cord-018182-lleti89n	161	7	afterload	afterload	NN
cord-018182-lleti89n	161	8	that	that	WDT
cord-018182-lleti89n	161	9	are	be	VBP
cord-018182-lleti89n	161	10	difficult	difficult	JJ
cord-018182-lleti89n	161	11	for	for	IN
cord-018182-lleti89n	161	12	the	the	DT
cord-018182-lleti89n	161	13	RV	RV	NNP
cord-018182-lleti89n	161	14	to	to	TO
cord-018182-lleti89n	161	15	overcome	overcome	VB
cord-018182-lleti89n	161	16	.	.	.
cord-018182-lleti89n	162	1	The	the	DT
cord-018182-lleti89n	162	2	right	right	JJ
cord-018182-lleti89n	162	3	heart	heart	NN
cord-018182-lleti89n	162	4	attempts	attempt	VBZ
cord-018182-lleti89n	162	5	to	to	TO
cord-018182-lleti89n	162	6	compensate	compensate	VB
cord-018182-lleti89n	162	7	for	for	IN
cord-018182-lleti89n	162	8	rising	rise	VBG
cord-018182-lleti89n	162	9	pressures	pressure	NNS
cord-018182-lleti89n	162	10	by	by	IN
cord-018182-lleti89n	162	11	dilating	dilate	VBG
cord-018182-lleti89n	162	12	acutely	acutely	RB
cord-018182-lleti89n	162	13	and	and	CC
cord-018182-lleti89n	162	14	hypertrophying	hypertrophy	VBG
cord-018182-lleti89n	162	15	chronically	chronically	RB
cord-018182-lleti89n	162	16	.	.	.
cord-018182-lleti89n	163	1	However	however	RB
cord-018182-lleti89n	163	2	,	,	,
cord-018182-lleti89n	163	3	these	these	DT
cord-018182-lleti89n	163	4	compensatory	compensatory	JJ
cord-018182-lleti89n	163	5	mechanisms	mechanism	NNS
cord-018182-lleti89n	163	6	are	be	VBP
cord-018182-lleti89n	163	7	maladaptive	maladaptive	JJ
cord-018182-lleti89n	163	8	,	,	,
cord-018182-lleti89n	163	9	and	and	CC
cord-018182-lleti89n	163	10	the	the	DT
cord-018182-lleti89n	163	11	resulting	result	VBG
cord-018182-lleti89n	163	12	volume	volume	NN
cord-018182-lleti89n	163	13	overload	overload	NN
cord-018182-lleti89n	163	14	that	that	WDT
cord-018182-lleti89n	163	15	ensues	ensue	VBZ
cord-018182-lleti89n	163	16	as	as	IN
cord-018182-lleti89n	163	17	cardiac	cardiac	JJ
cord-018182-lleti89n	163	18	output	output	NN
cord-018182-lleti89n	163	19	declines	decline	NNS
cord-018182-lleti89n	163	20	ultimately	ultimately	RB
cord-018182-lleti89n	163	21	leads	lead	VBZ
cord-018182-lleti89n	163	22	to	to	IN
cord-018182-lleti89n	163	23	RVF	RVF	NNP
cord-018182-lleti89n	163	24	.	.	.
cord-018182-lleti89n	164	1	As	as	IN
cord-018182-lleti89n	164	2	the	the	DT
cord-018182-lleti89n	164	3	RV	RV	NNP
cord-018182-lleti89n	164	4	fails	fail	VBZ
cord-018182-lleti89n	164	5	,	,	,
cord-018182-lleti89n	164	6	stroke	stroke	NN
cord-018182-lleti89n	164	7	volume	volume	NN
cord-018182-lleti89n	164	8	and	and	CC
cord-018182-lleti89n	164	9	cardiac	cardiac	JJ
cord-018182-lleti89n	164	10	output	output	NN
cord-018182-lleti89n	164	11	drop	drop	NN
cord-018182-lleti89n	164	12	further	further	RB
cord-018182-lleti89n	164	13	,	,	,
cord-018182-lleti89n	164	14	leading	lead	VBG
cord-018182-lleti89n	164	15	to	to	IN
cord-018182-lleti89n	164	16	cardiogenic	cardiogenic	JJ
cord-018182-lleti89n	164	17	shock	shock	NN
cord-018182-lleti89n	164	18	.	.	.
cord-018182-lleti89n	165	1	In	in	IN
cord-018182-lleti89n	165	2	the	the	DT
cord-018182-lleti89n	165	3	ICU	ICU	NNP
cord-018182-lleti89n	165	4	setting	setting	NN
cord-018182-lleti89n	165	5	,	,	,
cord-018182-lleti89n	165	6	RVF	RVF	NNP
cord-018182-lleti89n	165	7	is	be	VBZ
cord-018182-lleti89n	165	8	typically	typically	RB
cord-018182-lleti89n	165	9	acute	acute	JJ
cord-018182-lleti89n	165	10	but	but	CC
cord-018182-lleti89n	165	11	occasionally	occasionally	RB
cord-018182-lleti89n	165	12	may	may	MD
cord-018182-lleti89n	165	13	be	be	VB
cord-018182-lleti89n	165	14	due	due	JJ
cord-018182-lleti89n	165	15	to	to	IN
cord-018182-lleti89n	165	16	worsening	worsen	VBG
cord-018182-lleti89n	165	17	of	of	IN
cord-018182-lleti89n	165	18	underlying	underlie	VBG
cord-018182-lleti89n	165	19	chronic	chronic	NN
cord-018182-lleti89n	165	20	PH	PH	NNP
cord-018182-lleti89n	165	21	[	[	-LRB-
cord-018182-lleti89n	165	22	28	28	CD
cord-018182-lleti89n	165	23	,	,	,
cord-018182-lleti89n	165	24	29	29	CD
cord-018182-lleti89n	165	25	]	]	-RRB-
cord-018182-lleti89n	165	26	.	.	.
cord-018182-lleti89n	166	1	Additional	additional	JJ
cord-018182-lleti89n	166	2	elements	element	NNS
cord-018182-lleti89n	166	3	that	that	WDT
cord-018182-lleti89n	166	4	may	may	MD
cord-018182-lleti89n	166	5	contribute	contribute	VB
cord-018182-lleti89n	166	6	to	to	IN
cord-018182-lleti89n	166	7	impaired	impair	VBN
cord-018182-lleti89n	166	8	cardiac	cardiac	JJ
cord-018182-lleti89n	166	9	function	function	NN
cord-018182-lleti89n	166	10	include	include	VBP
cord-018182-lleti89n	166	11	compromised	compromise	VBN
cord-018182-lleti89n	166	12	filling	filling	NN
cord-018182-lleti89n	166	13	of	of	IN
cord-018182-lleti89n	166	14	the	the	DT
cord-018182-lleti89n	166	15	right	right	JJ
cord-018182-lleti89n	166	16	coronary	coronary	JJ
cord-018182-lleti89n	166	17	arteries	artery	NNS
cord-018182-lleti89n	166	18	due	due	JJ
cord-018182-lleti89n	166	19	to	to	IN
cord-018182-lleti89n	166	20	elevated	elevated	JJ
cord-018182-lleti89n	166	21	right	right	RB
cord-018182-lleti89n	166	22	-	-	HYPH
cord-018182-lleti89n	166	23	sided	sided	JJ
cord-018182-lleti89n	166	24	wall	wall	NN
cord-018182-lleti89n	166	25	tension	tension	NN
cord-018182-lleti89n	166	26	leading	lead	VBG
cord-018182-lleti89n	166	27	to	to	IN
cord-018182-lleti89n	166	28	myocardial	myocardial	JJ
cord-018182-lleti89n	166	29	ischemia	ischemia	NN
cord-018182-lleti89n	166	30	,	,	,
cord-018182-lleti89n	166	31	tricuspid	tricuspid	JJ
cord-018182-lleti89n	166	32	valvular	valvular	JJ
cord-018182-lleti89n	166	33	insufficiency	insufficiency	NN
cord-018182-lleti89n	166	34	,	,	,
cord-018182-lleti89n	166	35	and	and	CC
cord-018182-lleti89n	166	36	bowing	bowing	NN
cord-018182-lleti89n	166	37	of	of	IN
cord-018182-lleti89n	166	38	the	the	DT
cord-018182-lleti89n	166	39	interventricular	interventricular	JJ
cord-018182-lleti89n	166	40	septum	septum	NN
cord-018182-lleti89n	166	41	which	which	WDT
cord-018182-lleti89n	166	42	impinges	impinge	VBZ
cord-018182-lleti89n	166	43	on	on	IN
cord-018182-lleti89n	166	44	LV	LV	NNP
cord-018182-lleti89n	166	45	diastolic	diastolic	JJ
cord-018182-lleti89n	166	46	filling	filling	NN
cord-018182-lleti89n	166	47	(	(	-LRB-
cord-018182-lleti89n	166	48	enlargement	enlargement	NN
cord-018182-lleti89n	166	49	of	of	IN
cord-018182-lleti89n	166	50	the	the	DT
cord-018182-lleti89n	166	51	right	right	JJ
cord-018182-lleti89n	166	52	heart	heart	NN
cord-018182-lleti89n	166	53	due	due	JJ
cord-018182-lleti89n	166	54	to	to	IN
cord-018182-lleti89n	166	55	increased	increase	VBN
cord-018182-lleti89n	166	56	pressure	pressure	NN
cord-018182-lleti89n	166	57	and	and	CC
cord-018182-lleti89n	166	58	volume	volume	NN
cord-018182-lleti89n	166	59	displaces	displace	VBZ
cord-018182-lleti89n	166	60	the	the	DT
cord-018182-lleti89n	166	61	interventricular	interventricular	JJ
cord-018182-lleti89n	166	62	septum	septum	NN
cord-018182-lleti89n	166	63	toward	toward	IN
cord-018182-lleti89n	166	64	the	the	DT
cord-018182-lleti89n	166	65	LV	LV	NNP
cord-018182-lleti89n	166	66	)	)	-RRB-
cord-018182-lleti89n	166	67	.	.	.
cord-018182-lleti89n	167	1	Because	because	IN
cord-018182-lleti89n	167	2	the	the	DT
cord-018182-lleti89n	167	3	heart	heart	NN
cord-018182-lleti89n	167	4	functions	function	VBZ
cord-018182-lleti89n	167	5	in	in	IN
cord-018182-lleti89n	167	6	a	a	DT
cord-018182-lleti89n	167	7	fixed	fix	VBN
cord-018182-lleti89n	167	8	space	space	NN
cord-018182-lleti89n	167	9	within	within	IN
cord-018182-lleti89n	167	10	the	the	DT
cord-018182-lleti89n	167	11	pericardium	pericardium	NN
cord-018182-lleti89n	167	12	,	,	,
cord-018182-lleti89n	167	13	this	this	DT
cord-018182-lleti89n	167	14	displacement	displacement	NN
cord-018182-lleti89n	167	15	of	of	IN
cord-018182-lleti89n	167	16	the	the	DT
cord-018182-lleti89n	167	17	interventricular	interventricular	JJ
cord-018182-lleti89n	167	18	septum	septum	NN
cord-018182-lleti89n	167	19	impedes	impede	VBZ
cord-018182-lleti89n	167	20	LV	LV	NNP
cord-018182-lleti89n	167	21	filling	filling	NN
cord-018182-lleti89n	167	22	,	,	,
cord-018182-lleti89n	167	23	causing	cause	VBG
cord-018182-lleti89n	167	24	a	a	DT
cord-018182-lleti89n	167	25	further	further	JJ
cord-018182-lleti89n	167	26	decrease	decrease	NN
cord-018182-lleti89n	167	27	in	in	IN
cord-018182-lleti89n	167	28	systemic	systemic	JJ
cord-018182-lleti89n	167	29	stroke	stroke	NN
cord-018182-lleti89n	167	30	volume	volume	NN
cord-018182-lleti89n	167	31	and	and	CC
cord-018182-lleti89n	167	32	cardiac	cardiac	JJ
cord-018182-lleti89n	167	33	output	output	NN
cord-018182-lleti89n	167	34	.	.	.
cord-018182-lleti89n	168	1	This	this	DT
cord-018182-lleti89n	168	2	may	may	MD
cord-018182-lleti89n	168	3	result	result	VB
cord-018182-lleti89n	168	4	in	in	IN
cord-018182-lleti89n	168	5	hypotension	hypotension	NN
cord-018182-lleti89n	168	6	and	and	CC
cord-018182-lleti89n	168	7	ultimately	ultimately	RB
cord-018182-lleti89n	168	8	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	168	9	collapse	collapse	NN
cord-018182-lleti89n	168	10	[	[	-LRB-
cord-018182-lleti89n	168	11	28	28	CD
cord-018182-lleti89n	168	12	,	,	,
cord-018182-lleti89n	168	13	29	29	CD
cord-018182-lleti89n	168	14	]	]	-RRB-
cord-018182-lleti89n	168	15	.	.	.
cord-018182-lleti89n	169	1	In	in	IN
cord-018182-lleti89n	169	2	general	general	JJ
cord-018182-lleti89n	169	3	the	the	DT
cord-018182-lleti89n	169	4	outcome	outcome	NN
cord-018182-lleti89n	169	5	for	for	IN
cord-018182-lleti89n	169	6	patients	patient	NNS
cord-018182-lleti89n	169	7	with	with	IN
cord-018182-lleti89n	169	8	PH	PH	NNP
cord-018182-lleti89n	169	9	admitted	admit	VBD
cord-018182-lleti89n	169	10	to	to	IN
cord-018182-lleti89n	169	11	the	the	DT
cord-018182-lleti89n	169	12	hospital	hospital	NN
cord-018182-lleti89n	169	13	with	with	IN
cord-018182-lleti89n	169	14	RV	RV	NNP
cord-018182-lleti89n	169	15	failure	failure	NN
cord-018182-lleti89n	169	16	is	be	VBZ
cord-018182-lleti89n	169	17	poor	poor	JJ
cord-018182-lleti89n	169	18	,	,	,
cord-018182-lleti89n	169	19	with	with	IN
cord-018182-lleti89n	169	20	an	an	DT
cord-018182-lleti89n	169	21	estimated	estimate	VBN
cord-018182-lleti89n	169	22	mortality	mortality	NN
cord-018182-lleti89n	169	23	of	of	IN
cord-018182-lleti89n	169	24	30	30	CD
cord-018182-lleti89n	169	25	-	-	SYM
cord-018182-lleti89n	169	26	40	40	CD
cord-018182-lleti89n	169	27	%	%	NN
cord-018182-lleti89n	169	28	for	for	IN
cord-018182-lleti89n	169	29	those	those	DT
cord-018182-lleti89n	169	30	requiring	require	VBG
cord-018182-lleti89n	169	31	ICU	ICU	NNP
cord-018182-lleti89n	169	32	admission	admission	NN
cord-018182-lleti89n	169	33	[	[	-LRB-
cord-018182-lleti89n	169	34	30	30	CD
cord-018182-lleti89n	169	35	,	,	,
cord-018182-lleti89n	169	36	31	31	CD
cord-018182-lleti89n	169	37	]	]	-RRB-
cord-018182-lleti89n	169	38	.	.	.
cord-018182-lleti89n	170	1	The	the	DT
cord-018182-lleti89n	170	2	majority	majority	NN
cord-018182-lleti89n	170	3	of	of	IN
cord-018182-lleti89n	170	4	patients	patient	NNS
cord-018182-lleti89n	170	5	admitted	admit	VBN
cord-018182-lleti89n	170	6	to	to	IN
cord-018182-lleti89n	170	7	the	the	DT
cord-018182-lleti89n	170	8	ICU	ICU	NNP
cord-018182-lleti89n	170	9	with	with	IN
cord-018182-lleti89n	170	10	PH	PH	NNP
cord-018182-lleti89n	170	11	will	will	MD
cord-018182-lleti89n	170	12	have	have	VB
cord-018182-lleti89n	170	13	disease	disease	NN
cord-018182-lleti89n	170	14	that	that	WDT
cord-018182-lleti89n	170	15	is	be	VBZ
cord-018182-lleti89n	170	16	a	a	DT
cord-018182-lleti89n	170	17	result	result	NN
cord-018182-lleti89n	170	18	of	of	IN
cord-018182-lleti89n	170	19	underlying	underlie	VBG
cord-018182-lleti89n	170	20	critical	critical	JJ
cord-018182-lleti89n	170	21	illness	illness	NN
cord-018182-lleti89n	170	22	rather	rather	RB
cord-018182-lleti89n	170	23	than	than	IN
cord-018182-lleti89n	170	24	preexisting	preexist	VBG
cord-018182-lleti89n	170	25	PH	PH	NNP
cord-018182-lleti89n	170	26	.	.	.
cord-018182-lleti89n	171	1	Although	although	IN
cord-018182-lleti89n	171	2	not	not	RB
cord-018182-lleti89n	171	3	impossible	impossible	JJ
cord-018182-lleti89n	171	4	,	,	,
cord-018182-lleti89n	171	5	it	-PRON-	PRP
cord-018182-lleti89n	171	6	is	be	VBZ
cord-018182-lleti89n	171	7	uncommon	uncommon	JJ
cord-018182-lleti89n	171	8	to	to	TO
cord-018182-lleti89n	171	9	diagnose	diagnose	VB
cord-018182-lleti89n	171	10	de	de	NNP
cord-018182-lleti89n	171	11	novo	novo	NNP
cord-018182-lleti89n	171	12	PH	PH	NNP
cord-018182-lleti89n	171	13	as	as	IN
cord-018182-lleti89n	171	14	the	the	DT
cord-018182-lleti89n	171	15	primary	primary	JJ
cord-018182-lleti89n	171	16	reason	reason	NN
cord-018182-lleti89n	171	17	for	for	IN
cord-018182-lleti89n	171	18	ICU	ICU	NNP
cord-018182-lleti89n	171	19	admission	admission	NN
cord-018182-lleti89n	171	20	except	except	IN
cord-018182-lleti89n	171	21	in	in	IN
cord-018182-lleti89n	171	22	the	the	DT
cord-018182-lleti89n	171	23	setting	setting	NN
cord-018182-lleti89n	171	24	of	of	IN
cord-018182-lleti89n	171	25	acute	acute	JJ
cord-018182-lleti89n	171	26	pulmonary	pulmonary	JJ
cord-018182-lleti89n	171	27	embolism	embolism	NN
cord-018182-lleti89n	171	28	.	.	.
cord-018182-lleti89n	172	1	Many	many	JJ
cord-018182-lleti89n	172	2	triggering	trigger	VBG
cord-018182-lleti89n	172	3	factors	factor	NNS
cord-018182-lleti89n	172	4	causing	cause	VBG
cord-018182-lleti89n	172	5	or	or	CC
cord-018182-lleti89n	172	6	aggravating	aggravate	VBG
cord-018182-lleti89n	172	7	RV	rv	NN
cord-018182-lleti89n	172	8	failure	failure	NN
cord-018182-lleti89n	172	9	include	include	VBP
cord-018182-lleti89n	172	10	infection	infection	NN
cord-018182-lleti89n	172	11	,	,	,
cord-018182-lleti89n	172	12	anemia	anemia	NN
cord-018182-lleti89n	172	13	,	,	,
cord-018182-lleti89n	172	14	injury	injury	NN
cord-018182-lleti89n	172	15	,	,	,
cord-018182-lleti89n	172	16	surgery	surgery	NN
cord-018182-lleti89n	172	17	,	,	,
cord-018182-lleti89n	172	18	pregnancy	pregnancy	NN
cord-018182-lleti89n	172	19	,	,	,
cord-018182-lleti89n	172	20	medical	medical	JJ
cord-018182-lleti89n	172	21	therapy	therapy	NN
cord-018182-lleti89n	172	22	nonadherence	nonadherence	NN
cord-018182-lleti89n	172	23	,	,	,
cord-018182-lleti89n	172	24	pulmonary	pulmonary	JJ
cord-018182-lleti89n	172	25	embolism	embolism	NN
cord-018182-lleti89n	172	26	,	,	,
cord-018182-lleti89n	172	27	and	and	CC
cord-018182-lleti89n	172	28	arrhythmia	arrhythmia	NN
cord-018182-lleti89n	172	29	.	.	.
cord-018182-lleti89n	173	1	However	however	RB
cord-018182-lleti89n	173	2	,	,	,
cord-018182-lleti89n	173	3	it	-PRON-	PRP
cord-018182-lleti89n	173	4	is	be	VBZ
cord-018182-lleti89n	173	5	frequently	frequently	RB
cord-018182-lleti89n	173	6	the	the	DT
cord-018182-lleti89n	173	7	case	case	NN
cord-018182-lleti89n	173	8	that	that	IN
cord-018182-lleti89n	173	9	the	the	DT
cord-018182-lleti89n	173	10	exact	exact	JJ
cord-018182-lleti89n	173	11	trigger	trigger	NN
cord-018182-lleti89n	173	12	for	for	IN
cord-018182-lleti89n	173	13	decompensation	decompensation	NN
cord-018182-lleti89n	173	14	is	be	VBZ
cord-018182-lleti89n	173	15	never	never	RB
cord-018182-lleti89n	173	16	identified	identify	VBN
cord-018182-lleti89n	173	17	.	.	.
cord-018182-lleti89n	174	1	Identification	identification	NN
cord-018182-lleti89n	174	2	of	of	IN
cord-018182-lleti89n	174	3	an	an	DT
cord-018182-lleti89n	174	4	infection	infection	NN
cord-018182-lleti89n	174	5	in	in	IN
cord-018182-lleti89n	174	6	this	this	DT
cord-018182-lleti89n	174	7	patient	patient	JJ
cord-018182-lleti89n	174	8	population	population	NN
cord-018182-lleti89n	174	9	at	at	IN
cord-018182-lleti89n	174	10	any	any	DT
cord-018182-lleti89n	174	11	time	time	NN
cord-018182-lleti89n	174	12	during	during	IN
cord-018182-lleti89n	174	13	the	the	DT
cord-018182-lleti89n	174	14	ICU	ICU	NNP
cord-018182-lleti89n	174	15	stay	stay	NN
cord-018182-lleti89n	174	16	generally	generally	RB
cord-018182-lleti89n	174	17	portends	portend	VBZ
cord-018182-lleti89n	174	18	a	a	DT
cord-018182-lleti89n	174	19	poor	poor	JJ
cord-018182-lleti89n	174	20	prognosis	prognosis	NN
cord-018182-lleti89n	174	21	[	[	-LRB-
cord-018182-lleti89n	174	22	31	31	CD
cord-018182-lleti89n	174	23	,	,	,
cord-018182-lleti89n	174	24	32	32	CD
cord-018182-lleti89n	174	25	]	]	-RRB-
cord-018182-lleti89n	174	26	.	.	.
cord-018182-lleti89n	175	1	Acute	acute	JJ
cord-018182-lleti89n	175	2	RVF	RVF	NNP
cord-018182-lleti89n	175	3	typically	typically	RB
cord-018182-lleti89n	175	4	clinically	clinically	RB
cord-018182-lleti89n	175	5	presents	present	VBZ
cord-018182-lleti89n	175	6	with	with	IN
cord-018182-lleti89n	175	7	systemic	systemic	JJ
cord-018182-lleti89n	175	8	congestion	congestion	NN
cord-018182-lleti89n	175	9	and/or	and/or	CC
cord-018182-lleti89n	175	10	low	low	JJ
cord-018182-lleti89n	175	11	cardiac	cardiac	JJ
cord-018182-lleti89n	175	12	output	output	NN
cord-018182-lleti89n	175	13	.	.	.
cord-018182-lleti89n	176	1	This	this	DT
cord-018182-lleti89n	176	2	usually	usually	RB
cord-018182-lleti89n	176	3	manifests	manifest	VBZ
cord-018182-lleti89n	176	4	as	as	IN
cord-018182-lleti89n	176	5	chest	chest	NN
cord-018182-lleti89n	176	6	pain	pain	NN
cord-018182-lleti89n	176	7	,	,	,
cord-018182-lleti89n	176	8	dyspnea	dyspnea	NN
cord-018182-lleti89n	176	9	,	,	,
cord-018182-lleti89n	176	10	lightheadedness	lightheadedness	NN
cord-018182-lleti89n	176	11	,	,	,
cord-018182-lleti89n	176	12	syncope	syncope	NN
cord-018182-lleti89n	176	13	,	,	,
cord-018182-lleti89n	176	14	altered	alter	VBN
cord-018182-lleti89n	176	15	mental	mental	JJ
cord-018182-lleti89n	176	16	status	status	NN
cord-018182-lleti89n	176	17	,	,	,
cord-018182-lleti89n	176	18	cool	cool	JJ
cord-018182-lleti89n	176	19	extremities	extremity	NNS
cord-018182-lleti89n	176	20	,	,	,
cord-018182-lleti89n	176	21	and	and	CC
cord-018182-lleti89n	176	22	acute	acute	JJ
cord-018182-lleti89n	176	23	kidney	kidney	NN
cord-018182-lleti89n	176	24	injury	injury	NN
cord-018182-lleti89n	176	25	.	.	.
cord-018182-lleti89n	177	1	On	on	IN
cord-018182-lleti89n	177	2	exam	exam	NN
cord-018182-lleti89n	177	3	,	,	,
cord-018182-lleti89n	177	4	the	the	DT
cord-018182-lleti89n	177	5	jugular	jugular	NN
cord-018182-lleti89n	177	6	venous	venous	JJ
cord-018182-lleti89n	177	7	pressure	pressure	NN
cord-018182-lleti89n	177	8	will	will	MD
cord-018182-lleti89n	177	9	most	most	RBS
cord-018182-lleti89n	177	10	often	often	RB
cord-018182-lleti89n	177	11	be	be	VB
cord-018182-lleti89n	177	12	elevated	elevate	VBN
cord-018182-lleti89n	177	13	.	.	.
cord-018182-lleti89n	178	1	Other	other	JJ
cord-018182-lleti89n	178	2	overt	overt	JJ
cord-018182-lleti89n	178	3	signs	sign	NNS
cord-018182-lleti89n	178	4	of	of	IN
cord-018182-lleti89n	178	5	volume	volume	NN
cord-018182-lleti89n	178	6	overload	overload	NN
cord-018182-lleti89n	178	7	include	include	VBP
cord-018182-lleti89n	178	8	hepatomegaly	hepatomegaly	NNP
cord-018182-lleti89n	178	9	,	,	,
cord-018182-lleti89n	178	10	peripheral	peripheral	JJ
cord-018182-lleti89n	178	11	edema	edema	NN
cord-018182-lleti89n	178	12	,	,	,
cord-018182-lleti89n	178	13	ascites	ascites	NN
cord-018182-lleti89n	178	14	,	,	,
cord-018182-lleti89n	178	15	and	and	CC
cord-018182-lleti89n	178	16	crackles	crackle	VBZ
cord-018182-lleti89n	178	17	on	on	IN
cord-018182-lleti89n	178	18	pulmonary	pulmonary	JJ
cord-018182-lleti89n	178	19	auscultation	auscultation	NN
cord-018182-lleti89n	178	20	.	.	.
cord-018182-lleti89n	179	1	Cardiac	cardiac	JJ
cord-018182-lleti89n	179	2	exam	exam	NN
cord-018182-lleti89n	179	3	may	may	MD
cord-018182-lleti89n	179	4	reveal	reveal	VB
cord-018182-lleti89n	179	5	a	a	DT
cord-018182-lleti89n	179	6	RV	RV	NNP
cord-018182-lleti89n	179	7	heave	heave	NN
cord-018182-lleti89n	179	8	,	,	,
cord-018182-lleti89n	179	9	a	a	DT
cord-018182-lleti89n	179	10	tricuspid	tricuspid	JJ
cord-018182-lleti89n	179	11	regurgitant	regurgitant	NN
cord-018182-lleti89n	179	12	murmur	murmur	NN
cord-018182-lleti89n	179	13	,	,	,
cord-018182-lleti89n	179	14	an	an	DT
cord-018182-lleti89n	179	15	accentuated	accentuate	VBN
cord-018182-lleti89n	179	16	P2	P2	NNP
cord-018182-lleti89n	179	17	,	,	,
cord-018182-lleti89n	179	18	and/or	and/or	CC
cord-018182-lleti89n	179	19	an	an	DT
cord-018182-lleti89n	179	20	S3	S3	NNP
cord-018182-lleti89n	179	21	or	or	CC
cord-018182-lleti89n	179	22	S4	S4	NNP
cord-018182-lleti89n	179	23	gallop	gallop	NN
cord-018182-lleti89n	179	24	.	.	.
cord-018182-lleti89n	180	1	In	in	IN
cord-018182-lleti89n	180	2	the	the	DT
cord-018182-lleti89n	180	3	ICU	ICU	NNP
cord-018182-lleti89n	180	4	,	,	,
cord-018182-lleti89n	180	5	patients	patient	NNS
cord-018182-lleti89n	180	6	may	may	MD
cord-018182-lleti89n	180	7	present	present	VB
cord-018182-lleti89n	180	8	in	in	IN
cord-018182-lleti89n	180	9	extremis	extremis	NN
cord-018182-lleti89n	180	10	with	with	IN
cord-018182-lleti89n	180	11	tachycardia	tachycardia	NN
cord-018182-lleti89n	180	12	,	,	,
cord-018182-lleti89n	180	13	tachypnea	tachypnea	NN
cord-018182-lleti89n	180	14	,	,	,
cord-018182-lleti89n	180	15	hypoxia	hypoxia	NN
cord-018182-lleti89n	180	16	,	,	,
cord-018182-lleti89n	180	17	hypotension	hypotension	NN
cord-018182-lleti89n	180	18	,	,	,
cord-018182-lleti89n	180	19	and	and	CC
cord-018182-lleti89n	180	20	shock	shock	NN
cord-018182-lleti89n	180	21	as	as	IN
cord-018182-lleti89n	180	22	a	a	DT
cord-018182-lleti89n	180	23	result	result	NN
cord-018182-lleti89n	180	24	of	of	IN
cord-018182-lleti89n	180	25	inadequate	inadequate	JJ
cord-018182-lleti89n	180	26	cardiac	cardiac	JJ
cord-018182-lleti89n	180	27	output	output	NN
cord-018182-lleti89n	180	28	and	and	CC
cord-018182-lleti89n	180	29	elevated	elevated	JJ
cord-018182-lleti89n	180	30	filling	filling	NN
cord-018182-lleti89n	180	31	pressures	pressure	NNS
cord-018182-lleti89n	180	32	[	[	-LRB-
cord-018182-lleti89n	180	33	26	26	CD
cord-018182-lleti89n	180	34	,	,	,
cord-018182-lleti89n	180	35	33	33	CD
cord-018182-lleti89n	180	36	]	]	-RRB-
cord-018182-lleti89n	180	37	.	.	.
cord-018182-lleti89n	181	1	The	the	DT
cord-018182-lleti89n	181	2	initial	initial	JJ
cord-018182-lleti89n	181	3	diagnostic	diagnostic	JJ
cord-018182-lleti89n	181	4	workup	workup	NN
cord-018182-lleti89n	181	5	of	of	IN
cord-018182-lleti89n	181	6	any	any	DT
cord-018182-lleti89n	181	7	patient	patient	NN
cord-018182-lleti89n	181	8	admitted	admit	VBN
cord-018182-lleti89n	181	9	to	to	IN
cord-018182-lleti89n	181	10	the	the	DT
cord-018182-lleti89n	181	11	ICU	ICU	NNP
cord-018182-lleti89n	181	12	with	with	IN
cord-018182-lleti89n	181	13	known	know	VBN
cord-018182-lleti89n	181	14	underlying	underlie	VBG
cord-018182-lleti89n	181	15	PH	PH	NNP
cord-018182-lleti89n	181	16	with	with	IN
cord-018182-lleti89n	181	17	suspected	suspect	VBN
cord-018182-lleti89n	181	18	decompensation	decompensation	NN
cord-018182-lleti89n	181	19	or	or	CC
cord-018182-lleti89n	181	20	a	a	DT
cord-018182-lleti89n	181	21	possible	possible	JJ
cord-018182-lleti89n	181	22	new	new	JJ
cord-018182-lleti89n	181	23	diagnosis	diagnosis	NN
cord-018182-lleti89n	181	24	of	of	IN
cord-018182-lleti89n	181	25	undifferentiated	undifferentiated	JJ
cord-018182-lleti89n	181	26	RVF	RVF	NNS
cord-018182-lleti89n	181	27	should	should	MD
cord-018182-lleti89n	181	28	include	include	VB
cord-018182-lleti89n	181	29	the	the	DT
cord-018182-lleti89n	181	30	following	follow	VBG
cord-018182-lleti89n	181	31	:	:	:
cord-018182-lleti89n	181	32	•	•	XX
cord-018182-lleti89n	182	1	Infectious	infectious	JJ
cord-018182-lleti89n	182	2	workup	workup	NN
cord-018182-lleti89n	182	3	including	include	VBG
cord-018182-lleti89n	182	4	chest	chest	NN
cord-018182-lleti89n	182	5	radiograph	radiograph	NN
cord-018182-lleti89n	182	6	and	and	CC
cord-018182-lleti89n	182	7	cultures	culture	NNS
cord-018182-lleti89n	182	8	of	of	IN
cord-018182-lleti89n	182	9	the	the	DT
cord-018182-lleti89n	182	10	blood	blood	NN
cord-018182-lleti89n	182	11	,	,	,
cord-018182-lleti89n	182	12	urine	urine	NN
cord-018182-lleti89n	182	13	,	,	,
cord-018182-lleti89n	182	14	and	and	CC
cord-018182-lleti89n	182	15	sputum	sputum	NN
cord-018182-lleti89n	182	16	when	when	WRB
cord-018182-lleti89n	182	17	clinically	clinically	RB
cord-018182-lleti89n	182	18	indicated	indicate	VBN
cord-018182-lleti89n	182	19	•	•	NNP
cord-018182-lleti89n	182	20	Basic	basic	JJ
cord-018182-lleti89n	182	21	laboratory	laboratory	NN
cord-018182-lleti89n	182	22	evaluation	evaluation	NN
cord-018182-lleti89n	182	23	including	include	VBG
cord-018182-lleti89n	182	24	complete	complete	JJ
cord-018182-lleti89n	182	25	blood	blood	NN
cord-018182-lleti89n	182	26	count	count	NN
cord-018182-lleti89n	182	27	(	(	-LRB-
cord-018182-lleti89n	182	28	CBC	CBC	NNP
cord-018182-lleti89n	182	29	)	)	-RRB-
cord-018182-lleti89n	182	30	and	and	CC
cord-018182-lleti89n	182	31	comprehensive	comprehensive	JJ
cord-018182-lleti89n	182	32	metabolic	metabolic	JJ
cord-018182-lleti89n	182	33	panel	panel	NN
cord-018182-lleti89n	182	34	(	(	-LRB-
cord-018182-lleti89n	182	35	CMP	CMP	NNP
cord-018182-lleti89n	182	36	)	)	-RRB-
cord-018182-lleti89n	182	37	to	to	TO
cord-018182-lleti89n	182	38	assess	assess	VB
cord-018182-lleti89n	182	39	renal	renal	JJ
cord-018182-lleti89n	182	40	and	and	CC
cord-018182-lleti89n	182	41	hepatic	hepatic	JJ
cord-018182-lleti89n	182	42	function	function	NN
cord-018182-lleti89n	183	1	Ongoing	ongoing	JJ
cord-018182-lleti89n	183	2	monitoring	monitoring	NN
cord-018182-lleti89n	183	3	of	of	IN
cord-018182-lleti89n	183	4	end	end	NN
cord-018182-lleti89n	183	5	-	-	HYPH
cord-018182-lleti89n	183	6	organ	organ	NN
cord-018182-lleti89n	183	7	perfusion	perfusion	NN
cord-018182-lleti89n	183	8	including	include	VBG
cord-018182-lleti89n	183	9	renal	renal	JJ
cord-018182-lleti89n	183	10	,	,	,
cord-018182-lleti89n	183	11	hepatic	hepatic	JJ
cord-018182-lleti89n	183	12	,	,	,
cord-018182-lleti89n	183	13	and	and	CC
cord-018182-lleti89n	183	14	neurological	neurological	JJ
cord-018182-lleti89n	183	15	function	function	NN
cord-018182-lleti89n	183	16	is	be	VBZ
cord-018182-lleti89n	183	17	necessary	necessary	JJ
cord-018182-lleti89n	183	18	.	.	.
cord-018182-lleti89n	184	1	In	in	IN
cord-018182-lleti89n	184	2	addition	addition	NN
cord-018182-lleti89n	184	3	,	,	,
cord-018182-lleti89n	184	4	acute	acute	JJ
cord-018182-lleti89n	184	5	pulmonary	pulmonary	JJ
cord-018182-lleti89n	184	6	embolism	embolism	NN
cord-018182-lleti89n	184	7	should	should	MD
cord-018182-lleti89n	184	8	be	be	VB
cord-018182-lleti89n	184	9	excluded	exclude	VBN
cord-018182-lleti89n	184	10	in	in	IN
cord-018182-lleti89n	184	11	any	any	DT
cord-018182-lleti89n	184	12	patient	patient	NN
cord-018182-lleti89n	184	13	with	with	IN
cord-018182-lleti89n	184	14	decompensated	decompensated	JJ
cord-018182-lleti89n	184	15	or	or	CC
cord-018182-lleti89n	184	16	acute	acute	JJ
cord-018182-lleti89n	184	17	RVF	RVF	NNP
cord-018182-lleti89n	184	18	[	[	-LRB-
cord-018182-lleti89n	184	19	32	32	CD
cord-018182-lleti89n	184	20	]	]	-RRB-
cord-018182-lleti89n	184	21	.	.	.
cord-018182-lleti89n	185	1	In	in	IN
cord-018182-lleti89n	185	2	general	general	JJ
cord-018182-lleti89n	185	3	,	,	,
cord-018182-lleti89n	185	4	noninvasive	noninvasive	JJ
cord-018182-lleti89n	185	5	testing	testing	NN
cord-018182-lleti89n	185	6	and	and	CC
cord-018182-lleti89n	185	7	assessment	assessment	NN
cord-018182-lleti89n	185	8	of	of	IN
cord-018182-lleti89n	185	9	cardiac	cardiac	JJ
cord-018182-lleti89n	185	10	function	function	NN
cord-018182-lleti89n	185	11	are	be	VBP
cord-018182-lleti89n	185	12	preferred	prefer	VBN
cord-018182-lleti89n	185	13	prior	prior	RB
cord-018182-lleti89n	185	14	to	to	IN
cord-018182-lleti89n	185	15	RHC	RHC	NNP
cord-018182-lleti89n	185	16	.	.	.
cord-018182-lleti89n	186	1	Therefore	therefore	RB
cord-018182-lleti89n	186	2	,	,	,
cord-018182-lleti89n	186	3	transthoracic	transthoracic	NNP
cord-018182-lleti89n	186	4	echocardiography	echocardiography	NN
cord-018182-lleti89n	186	5	(	(	-LRB-
cord-018182-lleti89n	186	6	TTE	TTE	NNP
cord-018182-lleti89n	186	7	)	)	-RRB-
cord-018182-lleti89n	186	8	remains	remain	VBZ
cord-018182-lleti89n	186	9	the	the	DT
cord-018182-lleti89n	186	10	cornerstone	cornerstone	NN
cord-018182-lleti89n	186	11	of	of	IN
cord-018182-lleti89n	186	12	the	the	DT
cord-018182-lleti89n	186	13	diagnostic	diagnostic	JJ
cord-018182-lleti89n	186	14	evaluation	evaluation	NN
cord-018182-lleti89n	186	15	in	in	IN
cord-018182-lleti89n	186	16	patients	patient	NNS
cord-018182-lleti89n	186	17	with	with	IN
cord-018182-lleti89n	186	18	suspected	suspect	VBN
cord-018182-lleti89n	186	19	PH	PH	NNP
cord-018182-lleti89n	186	20	.	.	.
cord-018182-lleti89n	187	1	Assessment	assessment	NN
cord-018182-lleti89n	187	2	of	of	IN
cord-018182-lleti89n	187	3	both	both	CC
cord-018182-lleti89n	187	4	the	the	DT
cord-018182-lleti89n	187	5	pulmonary	pulmonary	JJ
cord-018182-lleti89n	187	6	arterial	arterial	JJ
cord-018182-lleti89n	187	7	systolic	systolic	JJ
cord-018182-lleti89n	187	8	pressure	pressure	NN
cord-018182-lleti89n	187	9	(	(	-LRB-
cord-018182-lleti89n	187	10	PASP	PASP	NNP
cord-018182-lleti89n	187	11	)	)	-RRB-
cord-018182-lleti89n	187	12	and	and	CC
cord-018182-lleti89n	187	13	RV	RV	NNP
cord-018182-lleti89n	187	14	structure	structure	NN
cord-018182-lleti89n	187	15	and	and	CC
cord-018182-lleti89n	187	16	function	function	NN
cord-018182-lleti89n	187	17	is	be	VBZ
cord-018182-lleti89n	187	18	an	an	DT
cord-018182-lleti89n	187	19	important	important	JJ
cord-018182-lleti89n	187	20	parameter	parameter	NN
cord-018182-lleti89n	187	21	in	in	IN
cord-018182-lleti89n	187	22	this	this	DT
cord-018182-lleti89n	187	23	evaluation	evaluation	NN
cord-018182-lleti89n	187	24	.	.	.
cord-018182-lleti89n	188	1	Right	right	JJ
cord-018182-lleti89n	188	2	atrial	atrial	JJ
cord-018182-lleti89n	188	3	enlargement	enlargement	NN
cord-018182-lleti89n	188	4	,	,	,
cord-018182-lleti89n	188	5	pericardial	pericardial	JJ
cord-018182-lleti89n	188	6	effusion	effusion	NN
cord-018182-lleti89n	188	7	,	,	,
cord-018182-lleti89n	188	8	low	low	JJ
cord-018182-lleti89n	188	9	tricuspid	tricuspid	JJ
cord-018182-lleti89n	188	10	annular	annular	JJ
cord-018182-lleti89n	188	11	plane	plane	NN
cord-018182-lleti89n	188	12	systolic	systolic	JJ
cord-018182-lleti89n	188	13	excursion	excursion	NN
cord-018182-lleti89n	188	14	(	(	-LRB-
cord-018182-lleti89n	188	15	TAPSE	TAPSE	NNP
cord-018182-lleti89n	188	16	)	)	-RRB-
cord-018182-lleti89n	188	17	,	,	,
cord-018182-lleti89n	188	18	and	and	CC
cord-018182-lleti89n	188	19	septal	septal	JJ
cord-018182-lleti89n	188	20	displacement	displacement	NN
cord-018182-lleti89n	188	21	are	be	VBP
cord-018182-lleti89n	188	22	poor	poor	JJ
cord-018182-lleti89n	188	23	prognostic	prognostic	JJ
cord-018182-lleti89n	188	24	indicators	indicator	NNS
cord-018182-lleti89n	188	25	.	.	.
cord-018182-lleti89n	189	1	In	in	IN
cord-018182-lleti89n	189	2	general	general	JJ
cord-018182-lleti89n	189	3	,	,	,
cord-018182-lleti89n	189	4	patients	patient	NNS
cord-018182-lleti89n	189	5	with	with	IN
cord-018182-lleti89n	189	6	an	an	DT
cord-018182-lleti89n	189	7	estimated	estimate	VBN
cord-018182-lleti89n	189	8	PASP	PASP	NNP
cord-018182-lleti89n	189	9	>	>	XX
cord-018182-lleti89n	189	10	40	40	CD
cord-018182-lleti89n	189	11	mmHg	mmHg	NNS
cord-018182-lleti89n	189	12	or	or	CC
cord-018182-lleti89n	189	13	a	a	DT
cord-018182-lleti89n	189	14	peak	peak	JJ
cord-018182-lleti89n	189	15	TR	tr	NN
cord-018182-lleti89n	189	16	jet	jet	NN
cord-018182-lleti89n	189	17	velocity	velocity	NN
cord-018182-lleti89n	189	18	≥3	≥3	NNP
cord-018182-lleti89n	189	19	m	m	NNP
cord-018182-lleti89n	189	20	/	/	SYM
cord-018182-lleti89n	189	21	s	s	NNS
cord-018182-lleti89n	189	22	are	be	VBP
cord-018182-lleti89n	189	23	likely	likely	JJ
cord-018182-lleti89n	189	24	to	to	TO
cord-018182-lleti89n	189	25	have	have	VB
cord-018182-lleti89n	189	26	PH	PH	NNP
cord-018182-lleti89n	189	27	confirmed	confirm	VBN
cord-018182-lleti89n	189	28	by	by	IN
cord-018182-lleti89n	189	29	RHC	RHC	NNP
cord-018182-lleti89n	189	30	.	.	.
cord-018182-lleti89n	190	1	However	however	RB
cord-018182-lleti89n	190	2	,	,	,
cord-018182-lleti89n	190	3	RHC	RHC	NNP
cord-018182-lleti89n	190	4	is	be	VBZ
cord-018182-lleti89n	190	5	the	the	DT
cord-018182-lleti89n	190	6	gold	gold	NN
cord-018182-lleti89n	190	7	standard	standard	NN
cord-018182-lleti89n	190	8	for	for	IN
cord-018182-lleti89n	190	9	confirming	confirm	VBG
cord-018182-lleti89n	190	10	diagnosis	diagnosis	NN
cord-018182-lleti89n	190	11	of	of	IN
cord-018182-lleti89n	190	12	PH	PH	NNP
cord-018182-lleti89n	190	13	.	.	.
cord-018182-lleti89n	191	1	Invasive	invasive	JJ
cord-018182-lleti89n	191	2	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	191	3	monitoring	monitoring	NN
cord-018182-lleti89n	191	4	remains	remain	VBZ
cord-018182-lleti89n	191	5	key	key	JJ
cord-018182-lleti89n	191	6	to	to	IN
cord-018182-lleti89n	191	7	the	the	DT
cord-018182-lleti89n	191	8	ongoing	ongoing	JJ
cord-018182-lleti89n	191	9	evaluation	evaluation	NN
cord-018182-lleti89n	191	10	and	and	CC
cord-018182-lleti89n	191	11	therapeutic	therapeutic	JJ
cord-018182-lleti89n	191	12	management	management	NN
cord-018182-lleti89n	191	13	of	of	IN
cord-018182-lleti89n	191	14	these	these	DT
cord-018182-lleti89n	191	15	patients	patient	NNS
cord-018182-lleti89n	191	16	[	[	-LRB-
cord-018182-lleti89n	191	17	28	28	CD
cord-018182-lleti89n	191	18	]	]	-RRB-
cord-018182-lleti89n	191	19	.	.	.
cord-018182-lleti89n	192	1	In	in	IN
cord-018182-lleti89n	192	2	patients	patient	NNS
cord-018182-lleti89n	192	3	with	with	IN
cord-018182-lleti89n	192	4	confirmed	confirm	VBN
cord-018182-lleti89n	192	5	or	or	CC
cord-018182-lleti89n	192	6	suspected	suspect	VBN
cord-018182-lleti89n	192	7	PH	PH	NNP
cord-018182-lleti89n	192	8	and/or	and/or	CC
cord-018182-lleti89n	192	9	RV	RV	NNP
cord-018182-lleti89n	192	10	failure	failure	NN
cord-018182-lleti89n	192	11	,	,	,
cord-018182-lleti89n	192	12	a	a	DT
cord-018182-lleti89n	192	13	thoughtful	thoughtful	JJ
cord-018182-lleti89n	192	14	,	,	,
cord-018182-lleti89n	192	15	systematic	systematic	JJ
cord-018182-lleti89n	192	16	,	,	,
cord-018182-lleti89n	192	17	and	and	CC
cord-018182-lleti89n	192	18	multidisciplinary	multidisciplinary	JJ
cord-018182-lleti89n	192	19	approach	approach	NN
cord-018182-lleti89n	192	20	to	to	IN
cord-018182-lleti89n	192	21	medical	medical	JJ
cord-018182-lleti89n	192	22	management	management	NN
cord-018182-lleti89n	192	23	should	should	MD
cord-018182-lleti89n	192	24	be	be	VB
cord-018182-lleti89n	192	25	pursued	pursue	VBN
cord-018182-lleti89n	192	26	.	.	.
cord-018182-lleti89n	193	1	Early	early	JJ
cord-018182-lleti89n	193	2	consultation	consultation	NN
cord-018182-lleti89n	193	3	with	with	IN
cord-018182-lleti89n	193	4	an	an	DT
cord-018182-lleti89n	193	5	expert	expert	NN
cord-018182-lleti89n	193	6	in	in	IN
cord-018182-lleti89n	193	7	pulmonary	pulmonary	JJ
cord-018182-lleti89n	193	8	hypertension	hypertension	NN
cord-018182-lleti89n	193	9	is	be	VBZ
cord-018182-lleti89n	193	10	advised	advise	VBN
cord-018182-lleti89n	193	11	as	as	IN
cord-018182-lleti89n	193	12	patients	patient	NNS
cord-018182-lleti89n	193	13	are	be	VBP
cord-018182-lleti89n	193	14	often	often	RB
cord-018182-lleti89n	193	15	misdiagnosed	misdiagnose	VBN
cord-018182-lleti89n	193	16	and	and	CC
cord-018182-lleti89n	193	17	referred	refer	VBN
cord-018182-lleti89n	193	18	late	late	RB
cord-018182-lleti89n	193	19	for	for	IN
cord-018182-lleti89n	193	20	consideration	consideration	NN
cord-018182-lleti89n	193	21	of	of	IN
cord-018182-lleti89n	193	22	advanced	advanced	JJ
cord-018182-lleti89n	193	23	therapies	therapy	NNS
cord-018182-lleti89n	193	24	.	.	.
cord-018182-lleti89n	194	1	Consultation	consultation	NN
cord-018182-lleti89n	194	2	with	with	IN
cord-018182-lleti89n	194	3	PH	PH	NNP
cord-018182-lleti89n	194	4	experts	expert	NNS
cord-018182-lleti89n	194	5	may	may	MD
cord-018182-lleti89n	194	6	also	also	RB
cord-018182-lleti89n	194	7	be	be	VB
cord-018182-lleti89n	194	8	necessary	necessary	JJ
cord-018182-lleti89n	194	9	to	to	TO
cord-018182-lleti89n	194	10	discern	discern	VB
cord-018182-lleti89n	194	11	PH	PH	NNP
cord-018182-lleti89n	194	12	and	and	CC
cord-018182-lleti89n	194	13	RV	RV	NNP
cord-018182-lleti89n	194	14	failure	failure	NN
cord-018182-lleti89n	194	15	from	from	IN
cord-018182-lleti89n	194	16	other	other	JJ
cord-018182-lleti89n	194	17	causes	cause	NNS
cord-018182-lleti89n	194	18	of	of	IN
cord-018182-lleti89n	194	19	clinical	clinical	JJ
cord-018182-lleti89n	194	20	decompensation	decompensation	NN
cord-018182-lleti89n	194	21	.	.	.
cord-018182-lleti89n	195	1	Collaboration	collaboration	NN
cord-018182-lleti89n	195	2	between	between	IN
cord-018182-lleti89n	195	3	local	local	JJ
cord-018182-lleti89n	195	4	medical	medical	JJ
cord-018182-lleti89n	195	5	centers	center	NNS
cord-018182-lleti89n	195	6	and	and	CC
cord-018182-lleti89n	195	7	PH	PH	NNP
cord-018182-lleti89n	195	8	specialty	specialty	NN
cord-018182-lleti89n	195	9	centers	center	NNS
cord-018182-lleti89n	195	10	to	to	TO
cord-018182-lleti89n	195	11	facilitate	facilitate	VB
cord-018182-lleti89n	195	12	referral	referral	JJ
cord-018182-lleti89n	195	13	and	and	CC
cord-018182-lleti89n	195	14	patient	patient	JJ
cord-018182-lleti89n	195	15	transfer	transfer	NN
cord-018182-lleti89n	195	16	when	when	WRB
cord-018182-lleti89n	195	17	necessary	necessary	JJ
cord-018182-lleti89n	195	18	is	be	VBZ
cord-018182-lleti89n	195	19	advised	advise	VBN
cord-018182-lleti89n	195	20	[	[	-LRB-
cord-018182-lleti89n	195	21	26	26	CD
cord-018182-lleti89n	195	22	]	]	-RRB-
cord-018182-lleti89n	195	23	.	.	.
cord-018182-lleti89n	196	1	Careful	careful	JJ
cord-018182-lleti89n	196	2	monitoring	monitoring	NN
cord-018182-lleti89n	196	3	of	of	IN
cord-018182-lleti89n	196	4	cardiac	cardiac	JJ
cord-018182-lleti89n	196	5	,	,	,
cord-018182-lleti89n	196	6	renal	renal	JJ
cord-018182-lleti89n	196	7	,	,	,
cord-018182-lleti89n	196	8	neurologic	neurologic	JJ
cord-018182-lleti89n	196	9	,	,	,
cord-018182-lleti89n	196	10	and	and	CC
cord-018182-lleti89n	196	11	hepatic	hepatic	JJ
cord-018182-lleti89n	196	12	function	function	NN
cord-018182-lleti89n	196	13	is	be	VBZ
cord-018182-lleti89n	196	14	essential	essential	JJ
cord-018182-lleti89n	196	15	in	in	IN
cord-018182-lleti89n	196	16	the	the	DT
cord-018182-lleti89n	196	17	care	care	NN
cord-018182-lleti89n	196	18	of	of	IN
cord-018182-lleti89n	196	19	the	the	DT
cord-018182-lleti89n	196	20	patient	patient	NN
cord-018182-lleti89n	196	21	with	with	IN
cord-018182-lleti89n	196	22	PH	PH	NNP
cord-018182-lleti89n	196	23	and/or	and/or	CC
cord-018182-lleti89n	196	24	RV	RV	NNP
cord-018182-lleti89n	196	25	failure	failure	NN
cord-018182-lleti89n	196	26	.	.	.
cord-018182-lleti89n	197	1	Urine	urine	NN
cord-018182-lleti89n	197	2	output	output	NN
cord-018182-lleti89n	197	3	,	,	,
cord-018182-lleti89n	197	4	laboratory	laboratory	NN
cord-018182-lleti89n	197	5	data	datum	NNS
cord-018182-lleti89n	197	6	(	(	-LRB-
cord-018182-lleti89n	197	7	liver	liver	NN
cord-018182-lleti89n	197	8	function	function	NN
cord-018182-lleti89n	197	9	tests	test	NNS
cord-018182-lleti89n	197	10	,	,	,
cord-018182-lleti89n	197	11	serum	serum	NN
cord-018182-lleti89n	197	12	creatinine	creatinine	NN
cord-018182-lleti89n	197	13	,	,	,
cord-018182-lleti89n	197	14	lactate	lactate	NN
cord-018182-lleti89n	197	15	,	,	,
cord-018182-lleti89n	197	16	troponin	troponin	JJ
cord-018182-lleti89n	197	17	)	)	-RRB-
cord-018182-lleti89n	197	18	,	,	,
cord-018182-lleti89n	197	19	and	and	CC
cord-018182-lleti89n	197	20	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	197	21	parameters	parameter	NNS
cord-018182-lleti89n	197	22	obtained	obtain	VBN
cord-018182-lleti89n	197	23	either	either	CC
cord-018182-lleti89n	197	24	from	from	IN
cord-018182-lleti89n	197	25	a	a	DT
cord-018182-lleti89n	197	26	central	central	JJ
cord-018182-lleti89n	197	27	venous	venous	JJ
cord-018182-lleti89n	197	28	catheter	catheter	NN
cord-018182-lleti89n	197	29	(	(	-LRB-
cord-018182-lleti89n	197	30	e.g.	e.g.	RB
cord-018182-lleti89n	197	31	,	,	,
cord-018182-lleti89n	197	32	central	central	JJ
cord-018182-lleti89n	197	33	venous	venous	JJ
cord-018182-lleti89n	197	34	pressure	pressure	NN
cord-018182-lleti89n	197	35	(	(	-LRB-
cord-018182-lleti89n	197	36	CVP	CVP	NNP
cord-018182-lleti89n	197	37	)	)	-RRB-
cord-018182-lleti89n	197	38	and	and	CC
cord-018182-lleti89n	197	39	central	central	JJ
cord-018182-lleti89n	197	40	venous	venous	JJ
cord-018182-lleti89n	197	41	saturation	saturation	NN
cord-018182-lleti89n	197	42	(	(	-LRB-
cord-018182-lleti89n	197	43	ScVO	ScVO	NNP
cord-018182-lleti89n	197	44	2	2	CD
cord-018182-lleti89n	197	45	)	)	-RRB-
cord-018182-lleti89n	197	46	)	)	-RRB-
cord-018182-lleti89n	197	47	or	or	CC
cord-018182-lleti89n	197	48	PA	PA	NNP
cord-018182-lleti89n	197	49	catheter	catheter	NN
cord-018182-lleti89n	197	50	(	(	-LRB-
cord-018182-lleti89n	197	51	right	right	JJ
cord-018182-lleti89n	197	52	atrial	atrial	JJ
cord-018182-lleti89n	197	53	pressure	pressure	NN
cord-018182-lleti89n	197	54	,	,	,
cord-018182-lleti89n	197	55	cardiac	cardiac	JJ
cord-018182-lleti89n	197	56	index	index	NN
cord-018182-lleti89n	197	57	,	,	,
cord-018182-lleti89n	197	58	mean	mean	VB
cord-018182-lleti89n	197	59	PA	PA	NNP
cord-018182-lleti89n	197	60	pressure	pressure	NN
cord-018182-lleti89n	197	61	,	,	,
cord-018182-lleti89n	197	62	PVR	PVR	NNP
cord-018182-lleti89n	197	63	and	and	CC
cord-018182-lleti89n	197	64	mixed	mixed	JJ
cord-018182-lleti89n	197	65	venous	venous	JJ
cord-018182-lleti89n	197	66	saturation	saturation	NN
cord-018182-lleti89n	197	67	(	(	-LRB-
cord-018182-lleti89n	197	68	SvO	SvO	NNP
cord-018182-lleti89n	197	69	2	2	CD
cord-018182-lleti89n	197	70	)	)	-RRB-
cord-018182-lleti89n	197	71	)	)	-RRB-
cord-018182-lleti89n	197	72	are	be	VBP
cord-018182-lleti89n	197	73	useful	useful	JJ
cord-018182-lleti89n	197	74	in	in	IN
cord-018182-lleti89n	197	75	making	make	VBG
cord-018182-lleti89n	197	76	management	management	NN
cord-018182-lleti89n	197	77	decisions	decision	NNS
cord-018182-lleti89n	197	78	.	.	.
cord-018182-lleti89n	198	1	Given	give	VBN
cord-018182-lleti89n	198	2	their	-PRON-	PRP$
cord-018182-lleti89n	198	3	complexity	complexity	NN
cord-018182-lleti89n	198	4	,	,	,
cord-018182-lleti89n	198	5	the	the	DT
cord-018182-lleti89n	198	6	use	use	NN
cord-018182-lleti89n	198	7	of	of	IN
cord-018182-lleti89n	198	8	RHC	RHC	NNP
cord-018182-lleti89n	198	9	and	and	CC
cord-018182-lleti89n	198	10	ongoing	ongoing	JJ
cord-018182-lleti89n	198	11	invasive	invasive	JJ
cord-018182-lleti89n	198	12	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	198	13	monitoring	monitoring	NN
cord-018182-lleti89n	198	14	is	be	VBZ
cord-018182-lleti89n	198	15	recommended	recommend	VBN
cord-018182-lleti89n	198	16	for	for	IN
cord-018182-lleti89n	198	17	patients	patient	NNS
cord-018182-lleti89n	198	18	with	with	IN
cord-018182-lleti89n	198	19	evidence	evidence	NN
cord-018182-lleti89n	198	20	of	of	IN
cord-018182-lleti89n	198	21	RV	RV	NNP
cord-018182-lleti89n	198	22	failure	failure	NN
cord-018182-lleti89n	198	23	requiring	require	VBG
cord-018182-lleti89n	198	24	ICU	ICU	NNP
cord-018182-lleti89n	198	25	admission	admission	NN
cord-018182-lleti89n	198	26	,	,	,
cord-018182-lleti89n	198	27	particularly	particularly	RB
cord-018182-lleti89n	198	28	in	in	IN
cord-018182-lleti89n	198	29	the	the	DT
cord-018182-lleti89n	198	30	setting	setting	NN
cord-018182-lleti89n	198	31	of	of	IN
cord-018182-lleti89n	198	32	vasoactive	vasoactive	JJ
cord-018182-lleti89n	198	33	agent	agent	NN
cord-018182-lleti89n	198	34	titration	titration	NN
cord-018182-lleti89n	198	35	[	[	-LRB-
cord-018182-lleti89n	198	36	32	32	CD
cord-018182-lleti89n	198	37	]	]	-RRB-
cord-018182-lleti89n	198	38	.	.	.
cord-018182-lleti89n	199	1	In	in	IN
cord-018182-lleti89n	199	2	general	general	JJ
cord-018182-lleti89n	199	3	,	,	,
cord-018182-lleti89n	199	4	management	management	NN
cord-018182-lleti89n	199	5	of	of	IN
cord-018182-lleti89n	199	6	acute	acute	JJ
cord-018182-lleti89n	199	7	RVF	RVF	NNP
cord-018182-lleti89n	199	8	and	and	CC
cord-018182-lleti89n	199	9	severe	severe	JJ
cord-018182-lleti89n	199	10	PH	ph	NN
cord-018182-lleti89n	199	11	in	in	IN
cord-018182-lleti89n	199	12	the	the	DT
cord-018182-lleti89n	199	13	critically	critically	RB
cord-018182-lleti89n	199	14	ill	ill	JJ
cord-018182-lleti89n	199	15	patient	patient	NN
cord-018182-lleti89n	199	16	focuses	focus	VBZ
cord-018182-lleti89n	199	17	on	on	IN
cord-018182-lleti89n	199	18	optimization	optimization	NN
cord-018182-lleti89n	199	19	of	of	IN
cord-018182-lleti89n	199	20	RV	rv	NN
cord-018182-lleti89n	199	21	preload	preload	NN
cord-018182-lleti89n	199	22	,	,	,
cord-018182-lleti89n	199	23	afterload	afterload	NN
cord-018182-lleti89n	199	24	,	,	,
cord-018182-lleti89n	199	25	and	and	CC
cord-018182-lleti89n	199	26	contractility	contractility	NN
cord-018182-lleti89n	199	27	while	while	IN
cord-018182-lleti89n	199	28	also	also	RB
cord-018182-lleti89n	199	29	carefully	carefully	RB
cord-018182-lleti89n	199	30	controlling	control	VBG
cord-018182-lleti89n	199	31	oxygenation	oxygenation	NN
cord-018182-lleti89n	199	32	,	,	,
cord-018182-lleti89n	199	33	ventilation	ventilation	NN
cord-018182-lleti89n	199	34	,	,	,
cord-018182-lleti89n	199	35	and	and	CC
cord-018182-lleti89n	199	36	cardiac	cardiac	JJ
cord-018182-lleti89n	199	37	rhythm	rhythm	NN
cord-018182-lleti89n	199	38	.	.	.
cord-018182-lleti89n	200	1	The	the	DT
cord-018182-lleti89n	200	2	search	search	NN
cord-018182-lleti89n	200	3	for	for	IN
cord-018182-lleti89n	200	4	potentially	potentially	RB
cord-018182-lleti89n	200	5	reversible	reversible	JJ
cord-018182-lleti89n	200	6	causes	cause	NNS
cord-018182-lleti89n	200	7	of	of	IN
cord-018182-lleti89n	200	8	decompensation	decompensation	NN
cord-018182-lleti89n	200	9	is	be	VBZ
cord-018182-lleti89n	200	10	critical	critical	JJ
cord-018182-lleti89n	200	11	.	.	.
cord-018182-lleti89n	201	1	If	if	IN
cord-018182-lleti89n	201	2	a	a	DT
cord-018182-lleti89n	201	3	specific	specific	JJ
cord-018182-lleti89n	201	4	cause	cause	NN
cord-018182-lleti89n	201	5	of	of	IN
cord-018182-lleti89n	201	6	RV	RV	NNP
cord-018182-lleti89n	201	7	failure	failure	NN
cord-018182-lleti89n	201	8	is	be	VBZ
cord-018182-lleti89n	201	9	identified	identify	VBN
cord-018182-lleti89n	201	10	,	,	,
cord-018182-lleti89n	201	11	management	management	NN
cord-018182-lleti89n	201	12	should	should	MD
cord-018182-lleti89n	201	13	include	include	VB
cord-018182-lleti89n	201	14	consideration	consideration	NN
cord-018182-lleti89n	201	15	of	of	IN
cord-018182-lleti89n	201	16	one	one	CD
cord-018182-lleti89n	201	17	of	of	IN
cord-018182-lleti89n	201	18	the	the	DT
cord-018182-lleti89n	201	19	directed	direct	VBN
cord-018182-lleti89n	201	20	therapies	therapy	NNS
cord-018182-lleti89n	201	21	listed	list	VBN
cord-018182-lleti89n	201	22	in	in	IN
cord-018182-lleti89n	201	23	Table	Table	NNP
cord-018182-lleti89n	201	24	13	13	CD
cord-018182-lleti89n	201	25	.8	.8	CD
cord-018182-lleti89n	201	26	.	.	.
cord-018182-lleti89n	202	1	Consideration	consideration	NN
cord-018182-lleti89n	202	2	of	of	IN
cord-018182-lleti89n	202	3	acute	acute	JJ
cord-018182-lleti89n	202	4	PE	PE	NNP
cord-018182-lleti89n	202	5	is	be	VBZ
cord-018182-lleti89n	202	6	important	important	JJ
cord-018182-lleti89n	202	7	in	in	IN
cord-018182-lleti89n	202	8	this	this	DT
cord-018182-lleti89n	202	9	population	population	NN
cord-018182-lleti89n	202	10	;	;	:
cord-018182-lleti89n	202	11	however	however	RB
cord-018182-lleti89n	202	12	,	,	,
cord-018182-lleti89n	202	13	its	-PRON-	PRP$
cord-018182-lleti89n	202	14	specific	specific	JJ
cord-018182-lleti89n	202	15	management	management	NN
cord-018182-lleti89n	202	16	will	will	MD
cord-018182-lleti89n	202	17	not	not	RB
cord-018182-lleti89n	202	18	be	be	VB
cord-018182-lleti89n	202	19	discussed	discuss	VBN
cord-018182-lleti89n	202	20	here	here	RB
cord-018182-lleti89n	202	21	.	.	.
cord-018182-lleti89n	203	1	Careful	careful	JJ
cord-018182-lleti89n	203	2	attention	attention	NN
cord-018182-lleti89n	203	3	to	to	IN
cord-018182-lleti89n	203	4	and	and	CC
cord-018182-lleti89n	203	5	evaluation	evaluation	NN
cord-018182-lleti89n	203	6	of	of	IN
cord-018182-lleti89n	203	7	fluid	fluid	JJ
cord-018182-lleti89n	203	8	status	status	NN
cord-018182-lleti89n	203	9	are	be	VBP
cord-018182-lleti89n	203	10	critical	critical	JJ
cord-018182-lleti89n	203	11	in	in	IN
cord-018182-lleti89n	203	12	the	the	DT
cord-018182-lleti89n	203	13	management	management	NN
cord-018182-lleti89n	203	14	of	of	IN
cord-018182-lleti89n	203	15	PH	PH	NNP
cord-018182-lleti89n	203	16	.	.	.
cord-018182-lleti89n	204	1	Assessment	assessment	NN
cord-018182-lleti89n	204	2	based	base	VBN
cord-018182-lleti89n	204	3	on	on	IN
cord-018182-lleti89n	204	4	clinical	clinical	JJ
cord-018182-lleti89n	204	5	exam	exam	NN
cord-018182-lleti89n	204	6	,	,	,
cord-018182-lleti89n	204	7	CVP	CVP	NNP
cord-018182-lleti89n	204	8	,	,	,
cord-018182-lleti89n	204	9	and	and	CC
cord-018182-lleti89n	204	10	invasive	invasive	JJ
cord-018182-lleti89n	204	11	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	204	12	monitoring	monitoring	NN
cord-018182-lleti89n	204	13	with	with	IN
cord-018182-lleti89n	204	14	RHC	RHC	NNP
cord-018182-lleti89n	204	15	may	may	MD
cord-018182-lleti89n	204	16	aid	aid	VB
cord-018182-lleti89n	204	17	in	in	IN
cord-018182-lleti89n	204	18	accurate	accurate	JJ
cord-018182-lleti89n	204	19	determination	determination	NN
cord-018182-lleti89n	204	20	of	of	IN
cord-018182-lleti89n	204	21	volume	volume	NN
cord-018182-lleti89n	204	22	status	status	NN
cord-018182-lleti89n	204	23	and	and	CC
cord-018182-lleti89n	204	24	fluid	fluid	JJ
cord-018182-lleti89n	204	25	management	management	NN
cord-018182-lleti89n	204	26	.	.	.
cord-018182-lleti89n	205	1	Occasionally	occasionally	RB
cord-018182-lleti89n	205	2	patients	patient	NNS
cord-018182-lleti89n	205	3	may	may	MD
cord-018182-lleti89n	205	4	be	be	VB
cord-018182-lleti89n	205	5	hypovolemic	hypovolemic	JJ
cord-018182-lleti89n	205	6	and	and	CC
cord-018182-lleti89n	205	7	require	require	VB
cord-018182-lleti89n	205	8	fluid	fluid	JJ
cord-018182-lleti89n	205	9	administration	administration	NN
cord-018182-lleti89n	205	10	.	.	.
cord-018182-lleti89n	206	1	However	however	RB
cord-018182-lleti89n	206	2	,	,	,
cord-018182-lleti89n	206	3	even	even	RB
cord-018182-lleti89n	206	4	in	in	IN
cord-018182-lleti89n	206	5	the	the	DT
cord-018182-lleti89n	206	6	case	case	NN
cord-018182-lleti89n	206	7	of	of	IN
cord-018182-lleti89n	206	8	suspected	suspect	VBN
cord-018182-lleti89n	206	9	sepsis	sepsis	NN
cord-018182-lleti89n	206	10	,	,	,
cord-018182-lleti89n	206	11	overly	overly	RB
cord-018182-lleti89n	206	12	judicious	judicious	JJ
cord-018182-lleti89n	206	13	administration	administration	NN
cord-018182-lleti89n	206	14	of	of	IN
cord-018182-lleti89n	206	15	fluids	fluid	NNS
cord-018182-lleti89n	206	16	may	may	MD
cord-018182-lleti89n	206	17	have	have	VB
cord-018182-lleti89n	206	18	detrimental	detrimental	JJ
cord-018182-lleti89n	206	19	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	206	20	effects	effect	NNS
cord-018182-lleti89n	206	21	in	in	IN
cord-018182-lleti89n	206	22	patients	patient	NNS
cord-018182-lleti89n	206	23	with	with	IN
cord-018182-lleti89n	206	24	compromised	compromise	VBN
cord-018182-lleti89n	206	25	RV	rv	NN
cord-018182-lleti89n	206	26	function	function	NN
cord-018182-lleti89n	206	27	.	.	.
cord-018182-lleti89n	207	1	Thus	thus	RB
cord-018182-lleti89n	207	2	,	,	,
cord-018182-lleti89n	207	3	cautious	cautious	JJ
cord-018182-lleti89n	207	4	administration	administration	NN
cord-018182-lleti89n	207	5	is	be	VBZ
cord-018182-lleti89n	207	6	advised	advise	VBN
cord-018182-lleti89n	207	7	.	.	.
cord-018182-lleti89n	208	1	A	a	DT
cord-018182-lleti89n	208	2	reasonable	reasonable	JJ
cord-018182-lleti89n	208	3	fluid	fluid	JJ
cord-018182-lleti89n	208	4	challenge	challenge	NN
cord-018182-lleti89n	208	5	for	for	IN
cord-018182-lleti89n	208	6	a	a	DT
cord-018182-lleti89n	208	7	patient	patient	NN
cord-018182-lleti89n	208	8	with	with	IN
cord-018182-lleti89n	208	9	acute	acute	JJ
cord-018182-lleti89n	208	10	RV	RV	NNP
cord-018182-lleti89n	208	11	dysfunction	dysfunction	NN
cord-018182-lleti89n	208	12	or	or	CC
cord-018182-lleti89n	208	13	acute	acute	JJ
cord-018182-lleti89n	208	14	PH	PH	NNP
cord-018182-lleti89n	208	15	is	be	VBZ
cord-018182-lleti89n	208	16	500	500	CD
cord-018182-lleti89n	208	17	ml	ml	NNS
cord-018182-lleti89n	208	18	of	of	IN
cord-018182-lleti89n	208	19	a	a	DT
cord-018182-lleti89n	208	20	normotonic	normotonic	JJ
cord-018182-lleti89n	208	21	fluid	fluid	NN
cord-018182-lleti89n	208	22	over	over	IN
cord-018182-lleti89n	208	23	15	15	CD
cord-018182-lleti89n	208	24	-	-	SYM
cord-018182-lleti89n	208	25	20	20	CD
cord-018182-lleti89n	208	26	min	min	NN
cord-018182-lleti89n	208	27	,	,	,
cord-018182-lleti89n	208	28	with	with	IN
cord-018182-lleti89n	208	29	a	a	DT
cord-018182-lleti89n	208	30	general	general	JJ
cord-018182-lleti89n	208	31	goal	goal	NN
cord-018182-lleti89n	208	32	CVP	CVP	NNP
cord-018182-lleti89n	208	33	target	target	NN
cord-018182-lleti89n	208	34	of	of	IN
cord-018182-lleti89n	208	35	10	10	CD
cord-018182-lleti89n	208	36	-	-	SYM
cord-018182-lleti89n	208	37	12	12	CD
cord-018182-lleti89n	208	38	mmHg	mmHg	NNS
cord-018182-lleti89n	208	39	[	[	-LRB-
cord-018182-lleti89n	208	40	26	26	CD
cord-018182-lleti89n	208	41	,	,	,
cord-018182-lleti89n	208	42	29	29	CD
cord-018182-lleti89n	208	43	,	,	,
cord-018182-lleti89n	208	44	33	33	CD
cord-018182-lleti89n	208	45	]	]	-RRB-
cord-018182-lleti89n	208	46	.	.	.
cord-018182-lleti89n	209	1	More	more	RBR
cord-018182-lleti89n	209	2	often	often	RB
cord-018182-lleti89n	209	3	than	than	IN
cord-018182-lleti89n	209	4	not	not	RB
cord-018182-lleti89n	209	5	,	,	,
cord-018182-lleti89n	209	6	patients	patient	NNS
cord-018182-lleti89n	209	7	with	with	IN
cord-018182-lleti89n	209	8	RVF	RVF	NNP
cord-018182-lleti89n	209	9	will	will	MD
cord-018182-lleti89n	209	10	be	be	VB
cord-018182-lleti89n	209	11	hypervolemic	hypervolemic	JJ
cord-018182-lleti89n	209	12	and	and	CC
cord-018182-lleti89n	209	13	require	require	VB
cord-018182-lleti89n	209	14	administration	administration	NN
cord-018182-lleti89n	209	15	of	of	IN
cord-018182-lleti89n	209	16	intravenous	intravenous	NNP
cord-018182-lleti89n	209	17	(	(	-LRB-
cord-018182-lleti89n	209	18	IV	IV	NNP
cord-018182-lleti89n	209	19	)	)	-RRB-
cord-018182-lleti89n	209	20	diuretics	diuretic	NNS
cord-018182-lleti89n	209	21	or	or	CC
cord-018182-lleti89n	209	22	acute	acute	JJ
cord-018182-lleti89n	209	23	hemofiltration	hemofiltration	NN
cord-018182-lleti89n	209	24	for	for	IN
cord-018182-lleti89n	209	25	volume	volume	NN
cord-018182-lleti89n	209	26	removal	removal	NN
cord-018182-lleti89n	209	27	.	.	.
cord-018182-lleti89n	210	1	IV	IV	NNP
cord-018182-lleti89n	210	2	loop	loop	NN
cord-018182-lleti89n	210	3	diuretics	diuretic	NNS
cord-018182-lleti89n	210	4	,	,	,
cord-018182-lleti89n	210	5	potentially	potentially	RB
cord-018182-lleti89n	210	6	in	in	IN
cord-018182-lleti89n	210	7	the	the	DT
cord-018182-lleti89n	210	8	form	form	NN
cord-018182-lleti89n	210	9	of	of	IN
cord-018182-lleti89n	210	10	a	a	DT
cord-018182-lleti89n	210	11	continuous	continuous	JJ
cord-018182-lleti89n	210	12	infusion	infusion	NN
cord-018182-lleti89n	210	13	to	to	TO
cord-018182-lleti89n	210	14	avoid	avoid	VB
cord-018182-lleti89n	210	15	abrupt	abrupt	JJ
cord-018182-lleti89n	210	16	swings	swing	NNS
cord-018182-lleti89n	210	17	in	in	IN
cord-018182-lleti89n	210	18	filling	fill	VBG
cord-018182-lleti89n	210	19	pressures	pressure	NNS
cord-018182-lleti89n	210	20	,	,	,
cord-018182-lleti89n	210	21	are	be	VBP
cord-018182-lleti89n	210	22	preferred	prefer	VBN
cord-018182-lleti89n	210	23	.	.	.
cord-018182-lleti89n	211	1	Extracorporeal	extracorporeal	JJ
cord-018182-lleti89n	211	2	fluid	fluid	JJ
cord-018182-lleti89n	211	3	removal	removal	NN
cord-018182-lleti89n	211	4	via	via	IN
cord-018182-lleti89n	211	5	ultrafiltration	ultrafiltration	NN
cord-018182-lleti89n	211	6	may	may	MD
cord-018182-lleti89n	211	7	be	be	VB
cord-018182-lleti89n	211	8	necessary	necessary	JJ
cord-018182-lleti89n	211	9	in	in	IN
cord-018182-lleti89n	211	10	the	the	DT
cord-018182-lleti89n	211	11	presence	presence	NN
cord-018182-lleti89n	211	12	of	of	IN
cord-018182-lleti89n	211	13	the	the	DT
cord-018182-lleti89n	211	14	cardiorenal	cardiorenal	NNP
cord-018182-lleti89n	211	15	syndrome	syndrome	NN
cord-018182-lleti89n	211	16	and	and	CC
cord-018182-lleti89n	211	17	diuretic	diuretic	JJ
cord-018182-lleti89n	211	18	resistance	resistance	NN
cord-018182-lleti89n	211	19	.	.	.
cord-018182-lleti89n	212	1	However	however	RB
cord-018182-lleti89n	212	2	,	,	,
cord-018182-lleti89n	212	3	either	either	DT
cord-018182-lleti89n	212	4	of	of	IN
cord-018182-lleti89n	212	5	these	these	DT
cord-018182-lleti89n	212	6	generally	generally	RB
cord-018182-lleti89n	212	7	portends	portend	VBZ
cord-018182-lleti89n	212	8	a	a	DT
cord-018182-lleti89n	212	9	poor	poor	JJ
cord-018182-lleti89n	212	10	prognosis	prognosis	NN
cord-018182-lleti89n	212	11	[	[	-LRB-
cord-018182-lleti89n	212	12	33	33	CD
cord-018182-lleti89n	212	13	]	]	-RRB-
cord-018182-lleti89n	212	14	.	.	.
cord-018182-lleti89n	213	1	Afterload	Afterload	NNP
cord-018182-lleti89n	213	2	reduction	reduction	NN
cord-018182-lleti89n	213	3	with	with	IN
cord-018182-lleti89n	213	4	the	the	DT
cord-018182-lleti89n	213	5	use	use	NN
cord-018182-lleti89n	213	6	of	of	IN
cord-018182-lleti89n	213	7	pulmonary	pulmonary	JJ
cord-018182-lleti89n	213	8	vasodilators	vasodilator	NNS
cord-018182-lleti89n	213	9	remains	remain	VBZ
cord-018182-lleti89n	213	10	an	an	DT
cord-018182-lleti89n	213	11	important	important	JJ
cord-018182-lleti89n	213	12	consideration	consideration	NN
cord-018182-lleti89n	213	13	in	in	IN
cord-018182-lleti89n	213	14	severe	severe	JJ
cord-018182-lleti89n	213	15	PH	PH	NNP
cord-018182-lleti89n	213	16	and	and	CC
cord-018182-lleti89n	213	17	RV	RV	NNP
cord-018182-lleti89n	213	18	failure	failure	NN
cord-018182-lleti89n	213	19	.	.	.
cord-018182-lleti89n	214	1	However	however	RB
cord-018182-lleti89n	214	2	,	,	,
cord-018182-lleti89n	214	3	systemic	systemic	JJ
cord-018182-lleti89n	214	4	PAH	pah	NN
cord-018182-lleti89n	214	5	-	-	HYPH
cord-018182-lleti89n	214	6	specific	specific	JJ
cord-018182-lleti89n	214	7	therapies	therapy	NNS
cord-018182-lleti89n	214	8	are	be	VBP
cord-018182-lleti89n	214	9	discouraged	discourage	VBN
cord-018182-lleti89n	214	10	in	in	IN
cord-018182-lleti89n	214	11	patients	patient	NNS
cord-018182-lleti89n	214	12	with	with	IN
cord-018182-lleti89n	214	13	PH	PH	NNP
cord-018182-lleti89n	214	14	of	of	IN
cord-018182-lleti89n	214	15	unknown	unknown	JJ
cord-018182-lleti89n	214	16	etiology	etiology	NN
cord-018182-lleti89n	214	17	.	.	.
cord-018182-lleti89n	215	1	Pulmonary	pulmonary	JJ
cord-018182-lleti89n	215	2	vasodilators	vasodilator	NNS
cord-018182-lleti89n	215	3	may	may	MD
cord-018182-lleti89n	215	4	be	be	VB
cord-018182-lleti89n	215	5	considered	consider	VBN
cord-018182-lleti89n	215	6	in	in	IN
cord-018182-lleti89n	215	7	cases	case	NNS
cord-018182-lleti89n	215	8	where	where	WRB
cord-018182-lleti89n	215	9	immediate	immediate	JJ
cord-018182-lleti89n	215	10	reduction	reduction	NN
cord-018182-lleti89n	215	11	of	of	IN
cord-018182-lleti89n	215	12	PVR	PVR	NNP
cord-018182-lleti89n	215	13	is	be	VBZ
cord-018182-lleti89n	215	14	necessary	necessary	JJ
cord-018182-lleti89n	215	15	[	[	-LRB-
cord-018182-lleti89n	215	16	33	33	CD
cord-018182-lleti89n	215	17	]	]	-RRB-
cord-018182-lleti89n	215	18	.	.	.
cord-018182-lleti89n	216	1	Both	both	DT
cord-018182-lleti89n	216	2	IV	IV	NNP
cord-018182-lleti89n	216	3	medications	medication	NNS
cord-018182-lleti89n	216	4	with	with	IN
cord-018182-lleti89n	216	5	selective	selective	JJ
cord-018182-lleti89n	216	6	effects	effect	NNS
cord-018182-lleti89n	216	7	on	on	IN
cord-018182-lleti89n	216	8	the	the	DT
cord-018182-lleti89n	216	9	pulmonary	pulmonary	JJ
cord-018182-lleti89n	216	10	vasculature	vasculature	NN
cord-018182-lleti89n	216	11	and	and	CC
cord-018182-lleti89n	216	12	inhaled	inhale	VBN
cord-018182-lleti89n	216	13	agents	agent	NNS
cord-018182-lleti89n	216	14	delivered	deliver	VBN
cord-018182-lleti89n	216	15	directly	directly	RB
cord-018182-lleti89n	216	16	to	to	IN
cord-018182-lleti89n	216	17	the	the	DT
cord-018182-lleti89n	216	18	lungs	lung	NNS
cord-018182-lleti89n	216	19	are	be	VBP
cord-018182-lleti89n	216	20	available	available	JJ
cord-018182-lleti89n	216	21	for	for	IN
cord-018182-lleti89n	216	22	this	this	DT
cord-018182-lleti89n	216	23	purpose	purpose	NN
cord-018182-lleti89n	216	24	.	.	.
cord-018182-lleti89n	217	1	See	see	VB
cord-018182-lleti89n	217	2	Table	table	NN
cord-018182-lleti89n	217	3	13	13	CD
cord-018182-lleti89n	217	4	.9	.9	CD
cord-018182-lleti89n	217	5	for	for	IN
cord-018182-lleti89n	217	6	a	a	DT
cord-018182-lleti89n	217	7	summary	summary	NN
cord-018182-lleti89n	217	8	of	of	IN
cord-018182-lleti89n	217	9	available	available	JJ
cord-018182-lleti89n	217	10	vasodilatory	vasodilatory	JJ
cord-018182-lleti89n	217	11	medications	medication	NNS
cord-018182-lleti89n	217	12	for	for	IN
cord-018182-lleti89n	217	13	PAH	PAH	NNP
cord-018182-lleti89n	217	14	in	in	IN
cord-018182-lleti89n	217	15	the	the	DT
cord-018182-lleti89n	217	16	ICU	ICU	NNP
cord-018182-lleti89n	217	17	setting	setting	NN
cord-018182-lleti89n	217	18	.	.	.
cord-018182-lleti89n	218	1	Oral	oral	JJ
cord-018182-lleti89n	218	2	agents	agent	NNS
cord-018182-lleti89n	218	3	including	include	VBG
cord-018182-lleti89n	218	4	PDE-5	PDE-5	NNP
cord-018182-lleti89n	218	5	inhibitors	inhibitor	NNS
cord-018182-lleti89n	218	6	and	and	CC
cord-018182-lleti89n	218	7	endothelin	endothelin	JJ
cord-018182-lleti89n	218	8	receptor	receptor	NN
cord-018182-lleti89n	218	9	antagonists	antagonist	NNS
cord-018182-lleti89n	218	10	(	(	-LRB-
cord-018182-lleti89n	218	11	ERAs	era	NNS
cord-018182-lleti89n	218	12	)	)	-RRB-
cord-018182-lleti89n	218	13	are	be	VBP
cord-018182-lleti89n	218	14	typically	typically	RB
cord-018182-lleti89n	218	15	not	not	RB
cord-018182-lleti89n	218	16	appropriate	appropriate	JJ
cord-018182-lleti89n	218	17	for	for	IN
cord-018182-lleti89n	218	18	use	use	NN
cord-018182-lleti89n	218	19	in	in	IN
cord-018182-lleti89n	218	20	the	the	DT
cord-018182-lleti89n	218	21	acute	acute	JJ
cord-018182-lleti89n	218	22	ICU	ICU	NNP
cord-018182-lleti89n	218	23	setting	setting	NN
cord-018182-lleti89n	218	24	(	(	-LRB-
cord-018182-lleti89n	218	25	except	except	IN
cord-018182-lleti89n	218	26	in	in	IN
cord-018182-lleti89n	218	27	selected	select	VBN
cord-018182-lleti89n	218	28	treatmentnaïve	treatmentnaïve	NN
cord-018182-lleti89n	218	29	PAH	PAH	NNP
cord-018182-lleti89n	218	30	patients	patient	NNS
cord-018182-lleti89n	218	31	who	who	WP
cord-018182-lleti89n	218	32	have	have	VBP
cord-018182-lleti89n	218	33	been	be	VBN
cord-018182-lleti89n	218	34	stabilized	stabilize	VBN
cord-018182-lleti89n	218	35	with	with	IN
cord-018182-lleti89n	218	36	IV	IV	NNP
cord-018182-lleti89n	218	37	prostanoids	prostanoids	NNP
cord-018182-lleti89n	218	38	)	)	-RRB-
cord-018182-lleti89n	218	39	and	and	CC
cord-018182-lleti89n	218	40	thus	thus	RB
cord-018182-lleti89n	218	41	will	will	MD
cord-018182-lleti89n	218	42	not	not	RB
cord-018182-lleti89n	218	43	be	be	VB
cord-018182-lleti89n	218	44	covered	cover	VBN
cord-018182-lleti89n	218	45	in	in	IN
cord-018182-lleti89n	218	46	this	this	DT
cord-018182-lleti89n	218	47	chapter	chapter	NN
cord-018182-lleti89n	218	48	.	.	.
cord-018182-lleti89n	219	1	It	-PRON-	PRP
cord-018182-lleti89n	219	2	is	be	VBZ
cord-018182-lleti89n	219	3	important	important	JJ
cord-018182-lleti89n	219	4	to	to	TO
cord-018182-lleti89n	219	5	note	note	VB
cord-018182-lleti89n	219	6	that	that	DT
cord-018182-lleti89n	219	7	treatment	treatment	NN
cord-018182-lleti89n	219	8	with	with	IN
cord-018182-lleti89n	219	9	PAH	pah	NN
cord-018182-lleti89n	219	10	-	-	HYPH
cord-018182-lleti89n	219	11	specific	specific	JJ
cord-018182-lleti89n	219	12	drugs	drug	NNS
cord-018182-lleti89n	219	13	has	have	VBZ
cord-018182-lleti89n	219	14	only	only	RB
cord-018182-lleti89n	219	15	been	be	VBN
cord-018182-lleti89n	219	16	associated	associate	VBN
cord-018182-lleti89n	219	17	with	with	IN
cord-018182-lleti89n	219	18	improved	improved	JJ
cord-018182-lleti89n	219	19	outcomes	outcome	NNS
cord-018182-lleti89n	219	20	in	in	IN
cord-018182-lleti89n	219	21	outpatients	outpatient	NNS
cord-018182-lleti89n	219	22	with	with	IN
cord-018182-lleti89n	219	23	chronic	chronic	JJ
cord-018182-lleti89n	219	24	PAH	PAH	NNP
cord-018182-lleti89n	219	25	.	.	.
cord-018182-lleti89n	220	1	Given	give	VBN
cord-018182-lleti89n	220	2	that	that	DT
cord-018182-lleti89n	220	3	few	few	JJ
cord-018182-lleti89n	220	4	critically	critically	RB
cord-018182-lleti89n	220	5	ill	ill	JJ
cord-018182-lleti89n	220	6	patients	patient	NNS
cord-018182-lleti89n	220	7	with	with	IN
cord-018182-lleti89n	220	8	PH	PH	NNP
cord-018182-lleti89n	220	9	and	and	CC
cord-018182-lleti89n	220	10	or	or	CC
cord-018182-lleti89n	220	11	RV	RV	NNP
cord-018182-lleti89n	220	12	failure	failure	NN
cord-018182-lleti89n	220	13	will	will	MD
cord-018182-lleti89n	220	14	have	have	VB
cord-018182-lleti89n	220	15	underlying	underlie	VBG
cord-018182-lleti89n	220	16	PAH	PAH	NNP
cord-018182-lleti89n	220	17	,	,	,
cord-018182-lleti89n	220	18	many	many	JJ
cord-018182-lleti89n	220	19	of	of	IN
cord-018182-lleti89n	220	20	these	these	DT
cord-018182-lleti89n	220	21	PAH	PAH	NNP
cord-018182-lleti89n	220	22	-	-	HYPH
cord-018182-lleti89n	220	23	specific	specific	JJ
cord-018182-lleti89n	220	24	drugs	drug	NNS
cord-018182-lleti89n	220	25	may	may	MD
cord-018182-lleti89n	220	26	not	not	RB
cord-018182-lleti89n	220	27	be	be	VB
cord-018182-lleti89n	220	28	warranted	warrant	VBN
cord-018182-lleti89n	220	29	.	.	.
cord-018182-lleti89n	221	1	In	in	IN
cord-018182-lleti89n	221	2	addition	addition	NN
cord-018182-lleti89n	221	3	,	,	,
cord-018182-lleti89n	221	4	no	no	DT
cord-018182-lleti89n	221	5	studies	study	NNS
cord-018182-lleti89n	221	6	have	have	VBP
cord-018182-lleti89n	221	7	demonstrated	demonstrate	VBN
cord-018182-lleti89n	221	8	clinical	clinical	JJ
cord-018182-lleti89n	221	9	superiority	superiority	NN
cord-018182-lleti89n	221	10	of	of	IN
cord-018182-lleti89n	221	11	one	one	CD
cord-018182-lleti89n	221	12	agent	agent	NN
cord-018182-lleti89n	221	13	[	[	-LRB-
cord-018182-lleti89n	221	14	29	29	CD
cord-018182-lleti89n	221	15	,	,	,
cord-018182-lleti89n	221	16	32	32	CD
cord-018182-lleti89n	221	17	,	,	,
cord-018182-lleti89n	221	18	33	33	CD
cord-018182-lleti89n	221	19	]	]	-RRB-
cord-018182-lleti89n	221	20	.	.	.
cord-018182-lleti89n	222	1	One	one	PRP
cord-018182-lleti89n	222	2	should	should	MD
cord-018182-lleti89n	222	3	also	also	RB
cord-018182-lleti89n	222	4	recall	recall	VB
cord-018182-lleti89n	222	5	that	that	IN
cord-018182-lleti89n	222	6	systemic	systemic	JJ
cord-018182-lleti89n	222	7	acidosis	acidosis	NN
cord-018182-lleti89n	222	8	results	result	NNS
cord-018182-lleti89n	222	9	in	in	IN
cord-018182-lleti89n	222	10	pulmonary	pulmonary	JJ
cord-018182-lleti89n	222	11	arterial	arterial	JJ
cord-018182-lleti89n	222	12	vasoconstriction	vasoconstriction	NN
cord-018182-lleti89n	222	13	.	.	.
cord-018182-lleti89n	223	1	Therefore	therefore	RB
cord-018182-lleti89n	223	2	,	,	,
cord-018182-lleti89n	223	3	abrogation	abrogation	NN
cord-018182-lleti89n	223	4	of	of	IN
cord-018182-lleti89n	223	5	acidosis	acidosis	NN
cord-018182-lleti89n	223	6	may	may	MD
cord-018182-lleti89n	223	7	be	be	VB
cord-018182-lleti89n	223	8	a	a	DT
cord-018182-lleti89n	223	9	useful	useful	JJ
cord-018182-lleti89n	223	10	therapeutic	therapeutic	JJ
cord-018182-lleti89n	223	11	goal	goal	NN
cord-018182-lleti89n	223	12	using	use	VBG
cord-018182-lleti89n	223	13	either	either	CC
cord-018182-lleti89n	223	14	augmented	augment	VBN
cord-018182-lleti89n	223	15	minute	minute	NN
cord-018182-lleti89n	223	16	ventilation	ventilation	NN
cord-018182-lleti89n	223	17	or	or	CC
cord-018182-lleti89n	223	18	intravenous	intravenous	JJ
cord-018182-lleti89n	223	19	fluids	fluid	NNS
cord-018182-lleti89n	223	20	that	that	WDT
cord-018182-lleti89n	223	21	influence	influence	NN
cord-018182-lleti89n	223	22	pH	ph	NN
cord-018182-lleti89n	223	23	such	such	JJ
cord-018182-lleti89n	223	24	as	as	IN
cord-018182-lleti89n	223	25	those	those	DT
cord-018182-lleti89n	223	26	constructed	construct	VBN
cord-018182-lleti89n	223	27	entirely	entirely	RB
cord-018182-lleti89n	223	28	of	of	IN
cord-018182-lleti89n	223	29	,	,	,
cord-018182-lleti89n	223	30	or	or	CC
cord-018182-lleti89n	223	31	supplemented	supplement	VBN
cord-018182-lleti89n	223	32	with	with	IN
cord-018182-lleti89n	223	33	,	,	,
cord-018182-lleti89n	223	34	sodium	sodium	NN
cord-018182-lleti89n	223	35	bicarbonate	bicarbonate	NN
cord-018182-lleti89n	223	36	or	or	CC
cord-018182-lleti89n	223	37	sodium	sodium	NN
cord-018182-lleti89n	223	38	acetate	acetate	NN
cord-018182-lleti89n	223	39	(	(	-LRB-
cord-018182-lleti89n	223	40	especially	especially	RB
cord-018182-lleti89n	223	41	when	when	WRB
cord-018182-lleti89n	223	42	NaHCO	nahco	JJ
cord-018182-lleti89n	223	43	3	3	CD
cord-018182-lleti89n	223	44	is	be	VBZ
cord-018182-lleti89n	223	45	in	in	IN
cord-018182-lleti89n	223	46	short	short	JJ
cord-018182-lleti89n	223	47	supply	supply	NN
cord-018182-lleti89n	223	48	)	)	-RRB-
cord-018182-lleti89n	223	49	.	.	.
cord-018182-lleti89n	224	1	A	a	DT
cord-018182-lleti89n	224	2	variety	variety	NN
cord-018182-lleti89n	224	3	of	of	IN
cord-018182-lleti89n	224	4	vasoactive	vasoactive	JJ
cord-018182-lleti89n	224	5	drugs	drug	NNS
cord-018182-lleti89n	224	6	may	may	MD
cord-018182-lleti89n	224	7	be	be	VB
cord-018182-lleti89n	224	8	used	use	VBN
cord-018182-lleti89n	224	9	in	in	IN
cord-018182-lleti89n	224	10	patients	patient	NNS
cord-018182-lleti89n	224	11	with	with	IN
cord-018182-lleti89n	224	12	RV	RV	NNP
cord-018182-lleti89n	224	13	failure	failure	NN
cord-018182-lleti89n	224	14	and	and	CC
cord-018182-lleti89n	224	15	critical	critical	JJ
cord-018182-lleti89n	224	16	illness	illness	NN
cord-018182-lleti89n	224	17	including	include	VBG
cord-018182-lleti89n	224	18	vasodilators	vasodilator	NNS
cord-018182-lleti89n	224	19	,	,	,
cord-018182-lleti89n	224	20	inotropes	inotrope	NNS
cord-018182-lleti89n	224	21	,	,	,
cord-018182-lleti89n	224	22	and/or	and/or	CC
cord-018182-lleti89n	224	23	vasopressors	vasopressor	NNS
cord-018182-lleti89n	224	24	.	.	.
cord-018182-lleti89n	225	1	The	the	DT
cord-018182-lleti89n	225	2	goal	goal	NN
cord-018182-lleti89n	225	3	of	of	IN
cord-018182-lleti89n	225	4	therapy	therapy	NN
cord-018182-lleti89n	225	5	is	be	VBZ
cord-018182-lleti89n	225	6	to	to	TO
cord-018182-lleti89n	225	7	maintain	maintain	VB
cord-018182-lleti89n	225	8	end	end	NN
cord-018182-lleti89n	225	9	-	-	HYPH
cord-018182-lleti89n	225	10	organ	organ	NN
cord-018182-lleti89n	225	11	perfusion	perfusion	NN
cord-018182-lleti89n	225	12	through	through	IN
cord-018182-lleti89n	225	13	reduction	reduction	NN
cord-018182-lleti89n	225	14	in	in	IN
cord-018182-lleti89n	225	15	PVR	PVR	NNP
cord-018182-lleti89n	225	16	without	without	IN
cord-018182-lleti89n	225	17	compromising	compromise	VBG
cord-018182-lleti89n	225	18	systemic	systemic	JJ
cord-018182-lleti89n	225	19	mean	mean	JJ
cord-018182-lleti89n	225	20	arterial	arterial	JJ
cord-018182-lleti89n	225	21	pressure	pressure	NN
cord-018182-lleti89n	225	22	and	and	CC
cord-018182-lleti89n	225	23	increasing	increase	VBG
cord-018182-lleti89n	225	24	cardiac	cardiac	JJ
cord-018182-lleti89n	225	25	output	output	NN
cord-018182-lleti89n	225	26	.	.	.
cord-018182-lleti89n	226	1	The	the	DT
cord-018182-lleti89n	226	2	selection	selection	NN
cord-018182-lleti89n	226	3	of	of	IN
cord-018182-lleti89n	226	4	specific	specific	JJ
cord-018182-lleti89n	226	5	therapies	therapy	NNS
cord-018182-lleti89n	226	6	or	or	CC
cord-018182-lleti89n	226	7	combinations	combination	NNS
cord-018182-lleti89n	226	8	thereof	thereof	RB
cord-018182-lleti89n	226	9	should	should	MD
cord-018182-lleti89n	226	10	be	be	VB
cord-018182-lleti89n	226	11	tailored	tailor	VBN
cord-018182-lleti89n	226	12	to	to	IN
cord-018182-lleti89n	226	13	each	each	DT
cord-018182-lleti89n	226	14	patient	patient	NN
cord-018182-lleti89n	226	15	,	,	,
cord-018182-lleti89n	226	16	taking	take	VBG
cord-018182-lleti89n	226	17	into	into	IN
cord-018182-lleti89n	226	18	account	account	NN
cord-018182-lleti89n	226	19	their	-PRON-	PRP$
cord-018182-lleti89n	226	20	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	226	21	,	,	,
cord-018182-lleti89n	226	22	respiratory	respiratory	JJ
cord-018182-lleti89n	226	23	,	,	,
cord-018182-lleti89n	226	24	and	and	CC
cord-018182-lleti89n	226	25	volume	volume	NN
cord-018182-lleti89n	226	26	status	status	NN
cord-018182-lleti89n	226	27	.	.	.
cord-018182-lleti89n	227	1	Patients	patient	NNS
cord-018182-lleti89n	227	2	requiring	require	VBG
cord-018182-lleti89n	227	3	initiation	initiation	NN
cord-018182-lleti89n	227	4	and	and	CC
cord-018182-lleti89n	227	5	titration	titration	NN
cord-018182-lleti89n	227	6	of	of	IN
cord-018182-lleti89n	227	7	these	these	DT
cord-018182-lleti89n	227	8	therapies	therapy	NNS
cord-018182-lleti89n	227	9	should	should	MD
cord-018182-lleti89n	227	10	have	have	VB
cord-018182-lleti89n	227	11	a	a	DT
cord-018182-lleti89n	227	12	pulmonary	pulmonary	JJ
cord-018182-lleti89n	227	13	artery	artery	NN
cord-018182-lleti89n	227	14	(	(	-LRB-
cord-018182-lleti89n	227	15	PA	PA	NNP
cord-018182-lleti89n	227	16	)	)	-RRB-
cord-018182-lleti89n	227	17	catheter	catheter	NN
cord-018182-lleti89n	227	18	placed	place	VBN
cord-018182-lleti89n	227	19	for	for	IN
cord-018182-lleti89n	227	20	ongoing	ongoing	JJ
cord-018182-lleti89n	227	21	management	management	NN
cord-018182-lleti89n	227	22	optimization	optimization	NN
cord-018182-lleti89n	227	23	;	;	:
cord-018182-lleti89n	227	24	while	while	IN
cord-018182-lleti89n	227	25	other	other	JJ
cord-018182-lleti89n	227	26	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	227	27	monitoring	monitoring	NN
cord-018182-lleti89n	227	28	techniques	technique	NNS
cord-018182-lleti89n	227	29	are	be	VBP
cord-018182-lleti89n	227	30	available	available	JJ
cord-018182-lleti89n	227	31	,	,	,
cord-018182-lleti89n	227	32	none	none	NN
cord-018182-lleti89n	227	33	directly	directly	RB
cord-018182-lleti89n	227	34	measure	measure	VB
cord-018182-lleti89n	227	35	PA	PA	NNP
cord-018182-lleti89n	227	36	pressures	pressure	NNS
cord-018182-lleti89n	227	37	.	.	.
cord-018182-lleti89n	228	1	A	a	DT
cord-018182-lleti89n	228	2	combination	combination	NN
cord-018182-lleti89n	228	3	of	of	IN
cord-018182-lleti89n	228	4	overstretching	overstretching	NN
cord-018182-lleti89n	228	5	,	,	,
cord-018182-lleti89n	228	6	derangements	derangement	NNS
cord-018182-lleti89n	228	7	in	in	IN
cord-018182-lleti89n	228	8	cellular	cellular	JJ
cord-018182-lleti89n	228	9	metabolism	metabolism	NN
cord-018182-lleti89n	228	10	,	,	,
cord-018182-lleti89n	228	11	and	and	CC
cord-018182-lleti89n	228	12	insufficient	insufficient	JJ
cord-018182-lleti89n	228	13	oxygen	oxygen	NN
cord-018182-lleti89n	228	14	delivery	delivery	NN
cord-018182-lleti89n	228	15	lead	lead	NN
cord-018182-lleti89n	228	16	to	to	IN
cord-018182-lleti89n	228	17	decreased	decrease	VBN
cord-018182-lleti89n	228	18	RV	RV	NNP
cord-018182-lleti89n	228	19	contractility	contractility	NN
cord-018182-lleti89n	228	20	in	in	IN
cord-018182-lleti89n	228	21	the	the	DT
cord-018182-lleti89n	228	22	setting	setting	NN
cord-018182-lleti89n	228	23	of	of	IN
cord-018182-lleti89n	228	24	critical	critical	JJ
cord-018182-lleti89n	228	25	illness	illness	NN
cord-018182-lleti89n	228	26	.	.	.
cord-018182-lleti89n	229	1	Dobutamine	Dobutamine	NNP
cord-018182-lleti89n	229	2	,	,	,
cord-018182-lleti89n	229	3	dopamine	dopamine	NN
cord-018182-lleti89n	229	4	,	,	,
cord-018182-lleti89n	229	5	and	and	CC
cord-018182-lleti89n	229	6	milrinone	milrinone	NN
cord-018182-lleti89n	229	7	are	be	VBP
cord-018182-lleti89n	229	8	the	the	DT
cord-018182-lleti89n	229	9	agents	agent	NNS
cord-018182-lleti89n	229	10	most	most	RBS
cord-018182-lleti89n	229	11	commonly	commonly	RB
cord-018182-lleti89n	229	12	used	use	VBN
cord-018182-lleti89n	229	13	for	for	IN
cord-018182-lleti89n	229	14	inotropic	inotropic	NNP
cord-018182-lleti89n	229	15	support	support	NN
cord-018182-lleti89n	229	16	in	in	IN
cord-018182-lleti89n	229	17	this	this	DT
cord-018182-lleti89n	229	18	patient	patient	JJ
cord-018182-lleti89n	229	19	population	population	NN
cord-018182-lleti89n	229	20	.	.	.
cord-018182-lleti89n	230	1	See	see	VB
cord-018182-lleti89n	230	2	Table	Table	NNP
cord-018182-lleti89n	230	3	13	13	CD
cord-018182-lleti89n	230	4	.10	.10	CD
cord-018182-lleti89n	230	5	for	for	IN
cord-018182-lleti89n	230	6	a	a	DT
cord-018182-lleti89n	230	7	summary	summary	NN
cord-018182-lleti89n	230	8	of	of	IN
cord-018182-lleti89n	230	9	the	the	DT
cord-018182-lleti89n	230	10	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	230	11	effects	effect	NNS
cord-018182-lleti89n	230	12	of	of	IN
cord-018182-lleti89n	230	13	commonly	commonly	RB
cord-018182-lleti89n	230	14	used	use	VBN
cord-018182-lleti89n	230	15	vasoactive	vasoactive	JJ
cord-018182-lleti89n	230	16	drugs	drug	NNS
cord-018182-lleti89n	230	17	.	.	.
cord-018182-lleti89n	231	1	There	there	EX
cord-018182-lleti89n	231	2	is	be	VBZ
cord-018182-lleti89n	231	3	debate	debate	NN
cord-018182-lleti89n	231	4	as	as	IN
cord-018182-lleti89n	231	5	to	to	IN
cord-018182-lleti89n	231	6	the	the	DT
cord-018182-lleti89n	231	7	first	first	JJ
cord-018182-lleti89n	231	8	-	-	HYPH
cord-018182-lleti89n	231	9	line	line	NN
cord-018182-lleti89n	231	10	agent	agent	NN
cord-018182-lleti89n	231	11	for	for	IN
cord-018182-lleti89n	231	12	inotropic	inotropic	NNP
cord-018182-lleti89n	231	13	support	support	NN
cord-018182-lleti89n	231	14	,	,	,
cord-018182-lleti89n	231	15	but	but	CC
cord-018182-lleti89n	231	16	in	in	IN
cord-018182-lleti89n	231	17	general	general	JJ
cord-018182-lleti89n	231	18	,	,	,
cord-018182-lleti89n	231	19	dobutamine	dobutamine	NNP
cord-018182-lleti89n	231	20	is	be	VBZ
cord-018182-lleti89n	231	21	preferred	prefer	VBN
cord-018182-lleti89n	231	22	over	over	IN
cord-018182-lleti89n	231	23	dopamine	dopamine	NN
cord-018182-lleti89n	231	24	for	for	IN
cord-018182-lleti89n	231	25	acute	acute	JJ
cord-018182-lleti89n	231	26	inotropic	inotropic	NNP
cord-018182-lleti89n	231	27	support	support	NN
cord-018182-lleti89n	231	28	in	in	IN
cord-018182-lleti89n	231	29	unstable	unstable	JJ
cord-018182-lleti89n	231	30	patients	patient	NNS
cord-018182-lleti89n	231	31	in	in	IN
cord-018182-lleti89n	231	32	the	the	DT
cord-018182-lleti89n	231	33	ICU	ICU	NNP
cord-018182-lleti89n	231	34	,	,	,
cord-018182-lleti89n	231	35	especially	especially	RB
cord-018182-lleti89n	231	36	since	since	IN
cord-018182-lleti89n	231	37	dopamine	dopamine	NN
cord-018182-lleti89n	231	38	is	be	VBZ
cord-018182-lleti89n	231	39	strongly	strongly	RB
cord-018182-lleti89n	231	40	pro	pro	JJ
cord-018182-lleti89n	231	41	-	-	JJ
cord-018182-lleti89n	231	42	arrhythmogenic	arrhythmogenic	JJ
cord-018182-lleti89n	231	43	at	at	IN
cord-018182-lleti89n	231	44	higher	high	JJR
cord-018182-lleti89n	231	45	doses	dose	NNS
cord-018182-lleti89n	231	46	.	.	.
cord-018182-lleti89n	232	1	Milrinone	Milrinone	NNP
cord-018182-lleti89n	232	2	is	be	VBZ
cord-018182-lleti89n	232	3	also	also	RB
cord-018182-lleti89n	232	4	often	often	RB
cord-018182-lleti89n	232	5	strongly	strongly	RB
cord-018182-lleti89n	232	6	considered	consider	VBN
cord-018182-lleti89n	232	7	,	,	,
cord-018182-lleti89n	232	8	particularly	particularly	RB
cord-018182-lleti89n	232	9	in	in	IN
cord-018182-lleti89n	232	10	patients	patient	NNS
cord-018182-lleti89n	232	11	with	with	IN
cord-018182-lleti89n	232	12	biventricular	biventricular	JJ
cord-018182-lleti89n	232	13	failure	failure	NN
cord-018182-lleti89n	232	14	.	.	.
cord-018182-lleti89n	233	1	However	however	RB
cord-018182-lleti89n	233	2	,	,	,
cord-018182-lleti89n	233	3	caution	caution	NN
cord-018182-lleti89n	233	4	should	should	MD
cord-018182-lleti89n	233	5	be	be	VB
cord-018182-lleti89n	233	6	exercised	exercise	VBN
cord-018182-lleti89n	233	7	given	give	VBN
cord-018182-lleti89n	233	8	the	the	DT
cord-018182-lleti89n	233	9	vasodilatory	vasodilatory	JJ
cord-018182-lleti89n	233	10	properties	property	NNS
cord-018182-lleti89n	233	11	of	of	IN
cord-018182-lleti89n	233	12	both	both	DT
cord-018182-lleti89n	233	13	agents	agent	NNS
cord-018182-lleti89n	233	14	(	(	-LRB-
cord-018182-lleti89n	233	15	dobutamine	dobutamine	NNP
cord-018182-lleti89n	233	16	and	and	CC
cord-018182-lleti89n	233	17	milrinone	milrinone	NNP
cord-018182-lleti89n	233	18	)	)	-RRB-
cord-018182-lleti89n	233	19	and	and	CC
cord-018182-lleti89n	233	20	their	-PRON-	PRP$
cord-018182-lleti89n	233	21	potential	potential	NN
cord-018182-lleti89n	233	22	to	to	TO
cord-018182-lleti89n	233	23	provoke	provoke	VB
cord-018182-lleti89n	233	24	systemic	systemic	JJ
cord-018182-lleti89n	233	25	hypotension	hypotension	NN
cord-018182-lleti89n	233	26	.	.	.
cord-018182-lleti89n	234	1	In	in	IN
cord-018182-lleti89n	234	2	some	some	DT
cord-018182-lleti89n	234	3	cases	case	NNS
cord-018182-lleti89n	234	4	,	,	,
cord-018182-lleti89n	234	5	concomitant	concomitant	JJ
cord-018182-lleti89n	234	6	administration	administration	NN
cord-018182-lleti89n	234	7	of	of	IN
cord-018182-lleti89n	234	8	a	a	DT
cord-018182-lleti89n	234	9	vasopressor	vasopressor	NN
cord-018182-lleti89n	234	10	may	may	MD
cord-018182-lleti89n	234	11	be	be	VB
cord-018182-lleti89n	234	12	necessary	necessary	JJ
cord-018182-lleti89n	234	13	to	to	TO
cord-018182-lleti89n	234	14	maintain	maintain	VB
cord-018182-lleti89n	234	15	systemic	systemic	JJ
cord-018182-lleti89n	234	16	precapillary	precapillary	JJ
cord-018182-lleti89n	234	17	arteriolar	arteriolar	JJ
cord-018182-lleti89n	234	18	sphincter	sphincter	NN
cord-018182-lleti89n	234	19	tone	tone	NN
cord-018182-lleti89n	234	20	,	,	,
cord-018182-lleti89n	234	21	mean	mean	VBP
cord-018182-lleti89n	234	22	arterial	arterial	JJ
cord-018182-lleti89n	234	23	pressure	pressure	NN
cord-018182-lleti89n	234	24	,	,	,
cord-018182-lleti89n	234	25	and	and	CC
cord-018182-lleti89n	234	26	cardiac	cardiac	JJ
cord-018182-lleti89n	234	27	output	output	NN
cord-018182-lleti89n	234	28	.	.	.
cord-018182-lleti89n	235	1	Adequate	adequate	JJ
cord-018182-lleti89n	235	2	systemic	systemic	JJ
cord-018182-lleti89n	235	3	blood	blood	NN
cord-018182-lleti89n	235	4	pressure	pressure	NN
cord-018182-lleti89n	235	5	is	be	VBZ
cord-018182-lleti89n	235	6	necessary	necessary	JJ
cord-018182-lleti89n	235	7	to	to	TO
cord-018182-lleti89n	235	8	maintain	maintain	VB
cord-018182-lleti89n	235	9	coronary	coronary	JJ
cord-018182-lleti89n	235	10	perfusion	perfusion	NN
cord-018182-lleti89n	235	11	and	and	CC
cord-018182-lleti89n	235	12	cardiac	cardiac	JJ
cord-018182-lleti89n	235	13	function	function	NN
cord-018182-lleti89n	235	14	,	,	,
cord-018182-lleti89n	235	15	and	and	CC
cord-018182-lleti89n	235	16	thus	thus	RB
cord-018182-lleti89n	235	17	vasopressors	vasopressor	NNS
cord-018182-lleti89n	235	18	may	may	MD
cord-018182-lleti89n	235	19	be	be	VB
cord-018182-lleti89n	235	20	a	a	DT
cord-018182-lleti89n	235	21	necessary	necessary	JJ
cord-018182-lleti89n	235	22	first	first	JJ
cord-018182-lleti89n	235	23	-	-	HYPH
cord-018182-lleti89n	235	24	line	line	NN
cord-018182-lleti89n	235	25	or	or	CC
cord-018182-lleti89n	235	26	adjunct	adjunct	NN
cord-018182-lleti89n	235	27	therapy	therapy	NN
cord-018182-lleti89n	235	28	[	[	-LRB-
cord-018182-lleti89n	235	29	32	32	CD
cord-018182-lleti89n	235	30	]	]	-RRB-
cord-018182-lleti89n	235	31	.	.	.
cord-018182-lleti89n	236	1	As	as	IN
cord-018182-lleti89n	236	2	with	with	IN
cord-018182-lleti89n	236	3	inotropic	inotropic	NNP
cord-018182-lleti89n	236	4	support	support	NN
cord-018182-lleti89n	236	5	,	,	,
cord-018182-lleti89n	236	6	careful	careful	JJ
cord-018182-lleti89n	236	7	selection	selection	NN
cord-018182-lleti89n	236	8	of	of	IN
cord-018182-lleti89n	236	9	the	the	DT
cord-018182-lleti89n	236	10	most	most	RBS
cord-018182-lleti89n	236	11	appropriate	appropriate	JJ
cord-018182-lleti89n	236	12	vasopressor	vasopressor	NN
cord-018182-lleti89n	236	13	will	will	MD
cord-018182-lleti89n	236	14	vary	vary	VB
cord-018182-lleti89n	236	15	depending	depend	VBG
cord-018182-lleti89n	236	16	on	on	IN
cord-018182-lleti89n	236	17	the	the	DT
cord-018182-lleti89n	236	18	clinical	clinical	JJ
cord-018182-lleti89n	236	19	scenario	scenario	NN
cord-018182-lleti89n	236	20	.	.	.
cord-018182-lleti89n	237	1	The	the	DT
cord-018182-lleti89n	237	2	increased	increased	JJ
cord-018182-lleti89n	237	3	risk	risk	NN
cord-018182-lleti89n	237	4	of	of	IN
cord-018182-lleti89n	237	5	tachyarrhythmias	tachyarrhythmias	XX
cord-018182-lleti89n	237	6	with	with	IN
cord-018182-lleti89n	237	7	all	all	DT
cord-018182-lleti89n	237	8	vasoactive	vasoactive	JJ
cord-018182-lleti89n	237	9	agents	agent	NNS
cord-018182-lleti89n	237	10	is	be	VBZ
cord-018182-lleti89n	237	11	an	an	DT
cord-018182-lleti89n	237	12	important	important	JJ
cord-018182-lleti89n	237	13	consideration	consideration	NN
cord-018182-lleti89n	237	14	given	give	VBN
cord-018182-lleti89n	237	15	the	the	DT
cord-018182-lleti89n	237	16	potential	potential	JJ
cord-018182-lleti89n	237	17	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	237	18	impact	impact	NN
cord-018182-lleti89n	237	19	on	on	IN
cord-018182-lleti89n	237	20	myocardial	myocardial	JJ
cord-018182-lleti89n	237	21	oxygen	oxygen	NN
cord-018182-lleti89n	237	22	consumption	consumption	NN
cord-018182-lleti89n	237	23	,	,	,
cord-018182-lleti89n	237	24	coronary	coronary	JJ
cord-018182-lleti89n	237	25	artery	artery	NN
cord-018182-lleti89n	237	26	flow	flow	NN
cord-018182-lleti89n	237	27	demand	demand	NN
cord-018182-lleti89n	237	28	,	,	,
cord-018182-lleti89n	237	29	and	and	CC
cord-018182-lleti89n	237	30	RV	rv	NN
cord-018182-lleti89n	237	31	filling	fill	VBG
cord-018182-lleti89n	237	32	time	time	NN
cord-018182-lleti89n	237	33	.	.	.
cord-018182-lleti89n	237	34	 	 	_SP
cord-018182-lleti89n	238	1	The	the	DT
cord-018182-lleti89n	238	2	presence	presence	NN
cord-018182-lleti89n	238	3	of	of	IN
cord-018182-lleti89n	238	4	atrioventricular	atrioventricular	JJ
cord-018182-lleti89n	238	5	synchrony	synchrony	NN
cord-018182-lleti89n	238	6	is	be	VBZ
cord-018182-lleti89n	238	7	critical	critical	JJ
cord-018182-lleti89n	238	8	for	for	IN
cord-018182-lleti89n	238	9	optimal	optimal	JJ
cord-018182-lleti89n	238	10	RV	rv	NN
cord-018182-lleti89n	238	11	filling	filling	NN
cord-018182-lleti89n	238	12	and	and	CC
cord-018182-lleti89n	238	13	maintenance	maintenance	NN
cord-018182-lleti89n	238	14	of	of	IN
cord-018182-lleti89n	238	15	cardiac	cardiac	JJ
cord-018182-lleti89n	238	16	output	output	NN
cord-018182-lleti89n	238	17	.	.	.
cord-018182-lleti89n	239	1	The	the	DT
cord-018182-lleti89n	239	2	presence	presence	NN
cord-018182-lleti89n	239	3	of	of	IN
cord-018182-lleti89n	239	4	atrial	atrial	JJ
cord-018182-lleti89n	239	5	arrhythmias	arrhythmia	NNS
cord-018182-lleti89n	239	6	(	(	-LRB-
cord-018182-lleti89n	239	7	e.g.	e.g.	RB
cord-018182-lleti89n	239	8	,	,	,
cord-018182-lleti89n	239	9	atrial	atrial	JJ
cord-018182-lleti89n	239	10	fibrillation	fibrillation	NN
cord-018182-lleti89n	239	11	,	,	,
cord-018182-lleti89n	239	12	atrial	atrial	JJ
cord-018182-lleti89n	239	13	flutter	flutter	NN
cord-018182-lleti89n	239	14	,	,	,
cord-018182-lleti89n	239	15	and	and	CC
cord-018182-lleti89n	239	16	supraventricular	supraventricular	JJ
cord-018182-lleti89n	239	17	tachycardia	tachycardia	NN
cord-018182-lleti89n	239	18	)	)	-RRB-
cord-018182-lleti89n	239	19	and	and	CC
cord-018182-lleti89n	239	20	electrical	electrical	JJ
cord-018182-lleti89n	239	21	conduction	conduction	NN
cord-018182-lleti89n	239	22	delays	delay	NNS
cord-018182-lleti89n	239	23	(	(	-LRB-
cord-018182-lleti89n	239	24	e.g.	e.g.	RB
cord-018182-lleti89n	239	25	,	,	,
cord-018182-lleti89n	239	26	complete	complete	JJ
cord-018182-lleti89n	239	27	heart	heart	NN
cord-018182-lleti89n	239	28	block	block	NN
cord-018182-lleti89n	239	29	)	)	-RRB-
cord-018182-lleti89n	239	30	is	be	VBZ
cord-018182-lleti89n	239	31	associated	associate	VBN
cord-018182-lleti89n	239	32	with	with	IN
cord-018182-lleti89n	239	33	worse	bad	JJR
cord-018182-lleti89n	239	34	outcomes	outcome	NNS
cord-018182-lleti89n	239	35	given	give	VBN
cord-018182-lleti89n	239	36	that	that	IN
cord-018182-lleti89n	239	37	the	the	DT
cord-018182-lleti89n	239	38	RV	RV	NNP
cord-018182-lleti89n	239	39	is	be	VBZ
cord-018182-lleti89n	239	40	highly	highly	RB
cord-018182-lleti89n	239	41	dependent	dependent	JJ
cord-018182-lleti89n	239	42	on	on	IN
cord-018182-lleti89n	239	43	atrial	atrial	JJ
cord-018182-lleti89n	239	44	contraction	contraction	NN
cord-018182-lleti89n	239	45	to	to	TO
cord-018182-lleti89n	239	46	maintain	maintain	VB
cord-018182-lleti89n	239	47	adequate	adequate	JJ
cord-018182-lleti89n	239	48	filling	filling	NN
cord-018182-lleti89n	239	49	.	.	.
cord-018182-lleti89n	240	1	Rate	rate	NN
cord-018182-lleti89n	240	2	control	control	NN
cord-018182-lleti89n	240	3	alone	alone	RB
cord-018182-lleti89n	240	4	is	be	VBZ
cord-018182-lleti89n	240	5	not	not	RB
cord-018182-lleti89n	240	6	typically	typically	RB
cord-018182-lleti89n	240	7	sufficient	sufficient	JJ
cord-018182-lleti89n	240	8	and	and	CC
cord-018182-lleti89n	240	9	rhythm	rhythm	NN
cord-018182-lleti89n	240	10	control	control	NN
cord-018182-lleti89n	240	11	is	be	VBZ
cord-018182-lleti89n	240	12	recommended	recommend	VBN
cord-018182-lleti89n	240	13	.	.	.
cord-018182-lleti89n	241	1	Electrical	electrical	JJ
cord-018182-lleti89n	241	2	cardioversion	cardioversion	NN
cord-018182-lleti89n	241	3	for	for	IN
cord-018182-lleti89n	241	4	tachyarrhythmias	tachyarrhythmias	NNP
cord-018182-lleti89n	241	5	and	and	CC
cord-018182-lleti89n	241	6	atrioventricular	atrioventricular	JJ
cord-018182-lleti89n	241	7	(	(	-LRB-
cord-018182-lleti89n	241	8	AV	av	NN
cord-018182-lleti89n	241	9	)	)	-RRB-
cord-018182-lleti89n	241	10	pacing	pace	VBG
cord-018182-lleti89n	241	11	for	for	IN
cord-018182-lleti89n	241	12	bradyarrhythmias	bradyarrhythmias	NNP
cord-018182-lleti89n	241	13	are	be	VBP
cord-018182-lleti89n	241	14	the	the	DT
cord-018182-lleti89n	241	15	first	first	JJ
cord-018182-lleti89n	241	16	-	-	HYPH
cord-018182-lleti89n	241	17	line	line	NN
cord-018182-lleti89n	241	18	treatments	treatment	NNS
cord-018182-lleti89n	241	19	for	for	IN
cord-018182-lleti89n	241	20	unstable	unstable	JJ
cord-018182-lleti89n	241	21	patients	patient	NNS
cord-018182-lleti89n	241	22	.	.	.
cord-018182-lleti89n	242	1	Amiodarone	Amiodarone	NNP
cord-018182-lleti89n	242	2	is	be	VBZ
cord-018182-lleti89n	242	3	the	the	DT
cord-018182-lleti89n	242	4	recommended	recommend	VBN
cord-018182-lleti89n	242	5	first	first	JJ
cord-018182-lleti89n	242	6	-	-	HYPH
cord-018182-lleti89n	242	7	line	line	NN
cord-018182-lleti89n	242	8	medication	medication	NN
cord-018182-lleti89n	242	9	for	for	IN
cord-018182-lleti89n	242	10	most	most	JJS
cord-018182-lleti89n	242	11	tachyarrhythmias	tachyarrhythmia	NNS
cord-018182-lleti89n	242	12	due	due	IN
cord-018182-lleti89n	242	13	to	to	IN
cord-018182-lleti89n	242	14	its	-PRON-	PRP$
cord-018182-lleti89n	242	15	lower	low	JJR
cord-018182-lleti89n	242	16	risk	risk	NN
cord-018182-lleti89n	242	17	of	of	IN
cord-018182-lleti89n	242	18	hypotension	hypotension	NN
cord-018182-lleti89n	242	19	and	and	CC
cord-018182-lleti89n	242	20	comparatively	comparatively	RB
cord-018182-lleti89n	242	21	fewer	few	JJR
cord-018182-lleti89n	242	22	negative	negative	JJ
cord-018182-lleti89n	242	23	inotropic	inotropic	JJ
cord-018182-lleti89n	242	24	effects	effect	NNS
cord-018182-lleti89n	242	25	.	.	.
cord-018182-lleti89n	243	1	The	the	DT
cord-018182-lleti89n	243	2	use	use	NN
cord-018182-lleti89n	243	3	of	of	IN
cord-018182-lleti89n	243	4	beta	beta	NN
cord-018182-lleti89n	243	5	-	-	HYPH
cord-018182-lleti89n	243	6	blockers	blocker	NNS
cord-018182-lleti89n	243	7	and	and	CC
cord-018182-lleti89n	243	8	calcium	calcium	NN
cord-018182-lleti89n	243	9	channel	channel	NN
cord-018182-lleti89n	243	10	blockers	blocker	NNS
cord-018182-lleti89n	243	11	is	be	VBZ
cord-018182-lleti89n	243	12	generally	generally	RB
cord-018182-lleti89n	243	13	avoided	avoid	VBN
cord-018182-lleti89n	243	14	given	give	VBN
cord-018182-lleti89n	243	15	that	that	IN
cord-018182-lleti89n	243	16	both	both	DT
cord-018182-lleti89n	243	17	classes	class	NNS
cord-018182-lleti89n	243	18	of	of	IN
cord-018182-lleti89n	243	19	agents	agent	NNS
cord-018182-lleti89n	243	20	may	may	MD
cord-018182-lleti89n	243	21	impair	impair	VB
cord-018182-lleti89n	243	22	RV	RV	NNP
cord-018182-lleti89n	243	23	contractility	contractility	NN
cord-018182-lleti89n	243	24	as	as	RB
cord-018182-lleti89n	243	25	well	well	RB
cord-018182-lleti89n	243	26	as	as	IN
cord-018182-lleti89n	243	27	AV	av	NN
cord-018182-lleti89n	243	28	nodal	nodal	JJ
cord-018182-lleti89n	243	29	conduction	conduction	NN
cord-018182-lleti89n	243	30	[	[	-LRB-
cord-018182-lleti89n	243	31	32	32	CD
cord-018182-lleti89n	243	32	,	,	,
cord-018182-lleti89n	243	33	33	33	CD
cord-018182-lleti89n	243	34	]	]	-RRB-
cord-018182-lleti89n	243	35	.	.	.
cord-018182-lleti89n	244	1	Hypoxemia	Hypoxemia	NNP
cord-018182-lleti89n	244	2	and	and	CC
cord-018182-lleti89n	244	3	hypercapnia	hypercapnia	NN
cord-018182-lleti89n	244	4	place	place	VBP
cord-018182-lleti89n	244	5	additional	additional	JJ
cord-018182-lleti89n	244	6	strain	strain	NN
cord-018182-lleti89n	244	7	on	on	IN
cord-018182-lleti89n	244	8	the	the	DT
cord-018182-lleti89n	244	9	heart	heart	NN
cord-018182-lleti89n	244	10	by	by	IN
cord-018182-lleti89n	244	11	inducing	induce	VBG
cord-018182-lleti89n	244	12	hypoxic	hypoxic	JJ
cord-018182-lleti89n	244	13	vasoconstriction	vasoconstriction	NN
cord-018182-lleti89n	244	14	with	with	IN
cord-018182-lleti89n	244	15	resultant	resultant	JJ
cord-018182-lleti89n	244	16	increases	increase	NNS
cord-018182-lleti89n	244	17	in	in	IN
cord-018182-lleti89n	244	18	PVR	PVR	NNP
cord-018182-lleti89n	244	19	and	and	CC
cord-018182-lleti89n	244	20	RV	RV	NNP
cord-018182-lleti89n	244	21	afterload	afterload	NN
cord-018182-lleti89n	244	22	.	.	.
cord-018182-lleti89n	245	1	Therefore	therefore	RB
cord-018182-lleti89n	245	2	,	,	,
cord-018182-lleti89n	245	3	maintenance	maintenance	NN
cord-018182-lleti89n	245	4	of	of	IN
cord-018182-lleti89n	245	5	normoxia	normoxia	NNP
cord-018182-lleti89n	245	6	(	(	-LRB-
cord-018182-lleti89n	245	7	peripheral	peripheral	JJ
cord-018182-lleti89n	245	8	O	o	NN
cord-018182-lleti89n	245	9	2	2	CD
cord-018182-lleti89n	245	10	saturation	saturation	NN
cord-018182-lleti89n	245	11	>	>	XX
cord-018182-lleti89n	245	12	90	90	CD
cord-018182-lleti89n	245	13	%	%	NN
cord-018182-lleti89n	245	14	)	)	-RRB-
cord-018182-lleti89n	245	15	and	and	CC
cord-018182-lleti89n	245	16	normocapnia	normocapnia	NNP
cord-018182-lleti89n	245	17	(	(	-LRB-
cord-018182-lleti89n	245	18	PaCO	paco	NN
cord-018182-lleti89n	245	19	2	2	CD
cord-018182-lleti89n	245	20	of	of	IN
cord-018182-lleti89n	245	21	35	35	CD
cord-018182-lleti89n	245	22	-	-	SYM
cord-018182-lleti89n	245	23	40	40	CD
cord-018182-lleti89n	245	24	mmHg	mmHg	NNS
cord-018182-lleti89n	245	25	)	)	-RRB-
cord-018182-lleti89n	245	26	is	be	VBZ
cord-018182-lleti89n	245	27	recommended	recommend	VBN
cord-018182-lleti89n	245	28	.	.	.
cord-018182-lleti89n	246	1	Any	any	DT
cord-018182-lleti89n	246	2	other	other	JJ
cord-018182-lleti89n	246	3	impedance	impedance	NN
cord-018182-lleti89n	246	4	to	to	TO
cord-018182-lleti89n	246	5	adequate	adequate	JJ
cord-018182-lleti89n	246	6	oxygen	oxygen	NN
cord-018182-lleti89n	246	7	delivery	delivery	NN
cord-018182-lleti89n	246	8	to	to	IN
cord-018182-lleti89n	246	9	the	the	DT
cord-018182-lleti89n	246	10	tissues	tissue	NNS
cord-018182-lleti89n	246	11	should	should	MD
cord-018182-lleti89n	246	12	be	be	VB
cord-018182-lleti89n	246	13	corrected	correct	VBN
cord-018182-lleti89n	246	14	,	,	,
cord-018182-lleti89n	246	15	including	include	VBG
cord-018182-lleti89n	246	16	anemia	anemia	NN
cord-018182-lleti89n	246	17	if	if	IN
cord-018182-lleti89n	246	18	present	present	JJ
cord-018182-lleti89n	246	19	(	(	-LRB-
cord-018182-lleti89n	247	1	goal	goal	NNP
cord-018182-lleti89n	247	2	Hgb	Hgb	NNP
cord-018182-lleti89n	247	3	>	>	XX
cord-018182-lleti89n	247	4	10	10	CD
cord-018182-lleti89n	247	5	g	g	NN
cord-018182-lleti89n	247	6	/	/	SYM
cord-018182-lleti89n	247	7	dL	dl	NN
cord-018182-lleti89n	247	8	)	)	-RRB-
cord-018182-lleti89n	248	1	[	[	-LRB-
cord-018182-lleti89n	248	2	32	32	CD
cord-018182-lleti89n	248	3	,	,	,
cord-018182-lleti89n	248	4	33	33	CD
cord-018182-lleti89n	248	5	]	]	-RRB-
cord-018182-lleti89n	248	6	.	.	.
cord-018182-lleti89n	249	1	In	in	IN
cord-018182-lleti89n	249	2	the	the	DT
cord-018182-lleti89n	249	3	setting	setting	NN
cord-018182-lleti89n	249	4	of	of	IN
cord-018182-lleti89n	249	5	respiratory	respiratory	JJ
cord-018182-lleti89n	249	6	decline	decline	NN
cord-018182-lleti89n	249	7	,	,	,
cord-018182-lleti89n	249	8	every	every	DT
cord-018182-lleti89n	249	9	effort	effort	NN
cord-018182-lleti89n	249	10	should	should	MD
cord-018182-lleti89n	249	11	be	be	VB
cord-018182-lleti89n	249	12	made	make	VBN
cord-018182-lleti89n	249	13	to	to	TO
cord-018182-lleti89n	249	14	avoid	avoid	VB
cord-018182-lleti89n	249	15	invasive	invasive	JJ
cord-018182-lleti89n	249	16	mechanical	mechanical	JJ
cord-018182-lleti89n	249	17	ventilation	ventilation	NN
cord-018182-lleti89n	249	18	if	if	IN
cord-018182-lleti89n	249	19	possible	possible	JJ
cord-018182-lleti89n	249	20	.	.	.
cord-018182-lleti89n	250	1	The	the	DT
cord-018182-lleti89n	250	2	risk	risk	NN
cord-018182-lleti89n	250	3	for	for	IN
cord-018182-lleti89n	250	4	systemic	systemic	JJ
cord-018182-lleti89n	250	5	hypotension	hypotension	NN
cord-018182-lleti89n	250	6	and	and	CC
cord-018182-lleti89n	250	7	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	250	8	collapse	collapse	NN
cord-018182-lleti89n	250	9	during	during	IN
cord-018182-lleti89n	250	10	intubation	intubation	NN
cord-018182-lleti89n	250	11	as	as	IN
cord-018182-lleti89n	250	12	a	a	DT
cord-018182-lleti89n	250	13	result	result	NN
cord-018182-lleti89n	250	14	of	of	IN
cord-018182-lleti89n	250	15	sedative	sedative	JJ
cord-018182-lleti89n	250	16	administration	administration	NN
cord-018182-lleti89n	250	17	is	be	VBZ
cord-018182-lleti89n	250	18	significant	significant	JJ
cord-018182-lleti89n	250	19	.	.	.
cord-018182-lleti89n	251	1	Ongoing	ongoing	JJ
cord-018182-lleti89n	251	2	ventilator	ventilator	NN
cord-018182-lleti89n	251	3	support	support	NN
cord-018182-lleti89n	251	4	with	with	IN
cord-018182-lleti89n	251	5	positive	positive	JJ
cord-018182-lleti89n	251	6	-	-	HYPH
cord-018182-lleti89n	251	7	pressure	pressure	NN
cord-018182-lleti89n	251	8	ventilation	ventilation	NN
cord-018182-lleti89n	251	9	may	may	MD
cord-018182-lleti89n	251	10	also	also	RB
cord-018182-lleti89n	251	11	have	have	VB
cord-018182-lleti89n	251	12	untoward	untoward	JJ
cord-018182-lleti89n	251	13	effects	effect	NNS
cord-018182-lleti89n	251	14	as	as	IN
cord-018182-lleti89n	251	15	the	the	DT
cord-018182-lleti89n	251	16	positive	positive	JJ
cord-018182-lleti89n	251	17	pressure	pressure	NN
cord-018182-lleti89n	251	18	increases	increase	VBZ
cord-018182-lleti89n	251	19	intrathoracic	intrathoracic	JJ
cord-018182-lleti89n	251	20	pressure	pressure	NN
cord-018182-lleti89n	251	21	and	and	CC
cord-018182-lleti89n	251	22	may	may	MD
cord-018182-lleti89n	251	23	result	result	VB
cord-018182-lleti89n	251	24	in	in	IN
cord-018182-lleti89n	251	25	decreased	decreased	JJ
cord-018182-lleti89n	251	26	venous	venous	JJ
cord-018182-lleti89n	251	27	return	return	NN
cord-018182-lleti89n	251	28	and	and	CC
cord-018182-lleti89n	251	29	hypotension	hypotension	NN
cord-018182-lleti89n	251	30	.	.	.
cord-018182-lleti89n	252	1	Therefore	therefore	RB
cord-018182-lleti89n	252	2	,	,	,
cord-018182-lleti89n	252	3	noninvasive	noninvasive	JJ
cord-018182-lleti89n	252	4	ventilation	ventilation	NN
cord-018182-lleti89n	252	5	should	should	MD
cord-018182-lleti89n	252	6	be	be	VB
cord-018182-lleti89n	252	7	considered	consider	VBN
cord-018182-lleti89n	252	8	prior	prior	RB
cord-018182-lleti89n	252	9	to	to	IN
cord-018182-lleti89n	252	10	intubation	intubation	NN
cord-018182-lleti89n	252	11	if	if	IN
cord-018182-lleti89n	252	12	the	the	DT
cord-018182-lleti89n	252	13	patient	patient	NN
cord-018182-lleti89n	252	14	's	's	POS
cord-018182-lleti89n	252	15	clinical	clinical	JJ
cord-018182-lleti89n	252	16	condition	condition	NN
cord-018182-lleti89n	252	17	is	be	VBZ
cord-018182-lleti89n	252	18	stable	stable	JJ
cord-018182-lleti89n	252	19	enough	enough	RB
cord-018182-lleti89n	252	20	for	for	IN
cord-018182-lleti89n	252	21	a	a	DT
cord-018182-lleti89n	252	22	trial	trial	NN
cord-018182-lleti89n	252	23	.	.	.
cord-018182-lleti89n	253	1	However	however	RB
cord-018182-lleti89n	253	2	,	,	,
cord-018182-lleti89n	253	3	if	if	IN
cord-018182-lleti89n	253	4	intubation	intubation	NN
cord-018182-lleti89n	253	5	is	be	VBZ
cord-018182-lleti89n	253	6	necessary	necessary	JJ
cord-018182-lleti89n	253	7	,	,	,
cord-018182-lleti89n	253	8	etomidate	etomidate	NNP
cord-018182-lleti89n	253	9	is	be	VBZ
cord-018182-lleti89n	253	10	the	the	DT
cord-018182-lleti89n	253	11	preferred	preferred	JJ
cord-018182-lleti89n	253	12	drug	drug	NN
cord-018182-lleti89n	253	13	for	for	IN
cord-018182-lleti89n	253	14	induction	induction	NN
cord-018182-lleti89n	253	15	of	of	IN
cord-018182-lleti89n	253	16	general	general	JJ
cord-018182-lleti89n	253	17	anesthesia	anesthesia	NNP
cord-018182-lleti89n	253	18	given	give	VBN
cord-018182-lleti89n	253	19	its	-PRON-	PRP$
cord-018182-lleti89n	253	20	minimal	minimal	JJ
cord-018182-lleti89n	253	21	effect	effect	NN
cord-018182-lleti89n	253	22	of	of	IN
cord-018182-lleti89n	253	23	cardiac	cardiac	JJ
cord-018182-lleti89n	253	24	contractility	contractility	NN
cord-018182-lleti89n	253	25	and	and	CC
cord-018182-lleti89n	253	26	vascular	vascular	JJ
cord-018182-lleti89n	253	27	tone	tone	NN
cord-018182-lleti89n	253	28	.	.	.
cord-018182-lleti89n	254	1	One	one	PRP
cord-018182-lleti89n	254	2	should	should	MD
cord-018182-lleti89n	254	3	recognize	recognize	VB
cord-018182-lleti89n	254	4	that	that	DT
cord-018182-lleti89n	254	5	controversy	controversy	NN
cord-018182-lleti89n	254	6	exists	exist	VBZ
cord-018182-lleti89n	254	7	regarding	regard	VBG
cord-018182-lleti89n	254	8	the	the	DT
cord-018182-lleti89n	254	9	effects	effect	NNS
cord-018182-lleti89n	254	10	of	of	IN
cord-018182-lleti89n	254	11	etomidate	etomidate	NN
cord-018182-lleti89n	254	12	on	on	IN
cord-018182-lleti89n	254	13	later	later	JJ
cord-018182-lleti89n	254	14	adrenal	adrenal	JJ
cord-018182-lleti89n	254	15	function	function	NN
cord-018182-lleti89n	254	16	,	,	,
cord-018182-lleti89n	254	17	and	and	CC
cord-018182-lleti89n	254	18	alternative	alternative	JJ
cord-018182-lleti89n	254	19	agents	agent	NNS
cord-018182-lleti89n	254	20	should	should	MD
cord-018182-lleti89n	254	21	be	be	VB
cord-018182-lleti89n	254	22	considered	consider	VBN
cord-018182-lleti89n	254	23	dictated	dictate	VBN
cord-018182-lleti89n	254	24	by	by	IN
cord-018182-lleti89n	254	25	provider	provider	NN
cord-018182-lleti89n	254	26	training	training	NN
cord-018182-lleti89n	254	27	and	and	CC
cord-018182-lleti89n	254	28	agent	agent	NN
cord-018182-lleti89n	254	29	availability	availability	NN
cord-018182-lleti89n	254	30	.	.	.
cord-018182-lleti89n	255	1	Preemptive	preemptive	JJ
cord-018182-lleti89n	255	2	administration	administration	NN
cord-018182-lleti89n	255	3	of	of	IN
cord-018182-lleti89n	255	4	vasopressors	vasopressor	NNS
cord-018182-lleti89n	255	5	and	and	CC
cord-018182-lleti89n	255	6	or	or	CC
cord-018182-lleti89n	255	7	inotropes	inotropes	NNP
cord-018182-lleti89n	255	8	prior	prior	RB
cord-018182-lleti89n	255	9	to	to	IN
cord-018182-lleti89n	255	10	intubation	intubation	NN
cord-018182-lleti89n	255	11	to	to	TO
cord-018182-lleti89n	255	12	offset	offset	VB
cord-018182-lleti89n	255	13	the	the	DT
cord-018182-lleti89n	255	14	commonly	commonly	RB
cord-018182-lleti89n	255	15	induced	induce	VBN
cord-018182-lleti89n	255	16	hypotension	hypotension	NN
cord-018182-lleti89n	255	17	should	should	MD
cord-018182-lleti89n	255	18	also	also	RB
cord-018182-lleti89n	255	19	be	be	VB
cord-018182-lleti89n	255	20	considered	consider	VBN
cord-018182-lleti89n	255	21	[	[	-LRB-
cord-018182-lleti89n	255	22	32	32	CD
cord-018182-lleti89n	255	23	,	,	,
cord-018182-lleti89n	255	24	35	35	CD
cord-018182-lleti89n	255	25	]	]	-RRB-
cord-018182-lleti89n	255	26	.	.	.
cord-018182-lleti89n	256	1	In	in	IN
cord-018182-lleti89n	256	2	select	select	JJ
cord-018182-lleti89n	256	3	patients	patient	NNS
cord-018182-lleti89n	256	4	with	with	IN
cord-018182-lleti89n	256	5	medically	medically	RB
cord-018182-lleti89n	256	6	refractory	refractory	JJ
cord-018182-lleti89n	256	7	PH	PH	NNP
cord-018182-lleti89n	256	8	and/or	and/or	CC
cord-018182-lleti89n	256	9	RVF	RVF	NNP
cord-018182-lleti89n	256	10	,	,	,
cord-018182-lleti89n	256	11	advanced	advanced	JJ
cord-018182-lleti89n	256	12	therapies	therapy	NNS
cord-018182-lleti89n	256	13	including	include	VBG
cord-018182-lleti89n	256	14	mechanical	mechanical	JJ
cord-018182-lleti89n	256	15	circulatory	circulatory	JJ
cord-018182-lleti89n	256	16	support	support	NN
cord-018182-lleti89n	256	17	and	and	CC
cord-018182-lleti89n	256	18	bilateral	bilateral	JJ
cord-018182-lleti89n	256	19	lung	lung	NN
cord-018182-lleti89n	256	20	transplantation	transplantation	NN
cord-018182-lleti89n	256	21	may	may	MD
cord-018182-lleti89n	256	22	be	be	VB
cord-018182-lleti89n	256	23	considered	consider	VBN
cord-018182-lleti89n	256	24	.	.	.
cord-018182-lleti89n	257	1	Right	right	UH
cord-018182-lleti89n	257	2	ventricular	ventricular	JJ
cord-018182-lleti89n	257	3	assist	assist	VB
cord-018182-lleti89n	257	4	devices	device	NNS
cord-018182-lleti89n	257	5	may	may	MD
cord-018182-lleti89n	257	6	be	be	VB
cord-018182-lleti89n	257	7	used	use	VBN
cord-018182-lleti89n	257	8	as	as	IN
cord-018182-lleti89n	257	9	a	a	DT
cord-018182-lleti89n	257	10	bridge	bridge	NN
cord-018182-lleti89n	257	11	to	to	TO
cord-018182-lleti89n	257	12	durable	durable	JJ
cord-018182-lleti89n	257	13	mechanical	mechanical	JJ
cord-018182-lleti89n	257	14	support	support	NN
cord-018182-lleti89n	257	15	or	or	CC
cord-018182-lleti89n	257	16	as	as	IN
cord-018182-lleti89n	257	17	a	a	DT
cord-018182-lleti89n	257	18	bridge	bridge	NN
cord-018182-lleti89n	257	19	to	to	IN
cord-018182-lleti89n	257	20	recovery	recovery	NN
cord-018182-lleti89n	257	21	.	.	.
cord-018182-lleti89n	258	1	They	-PRON-	PRP
cord-018182-lleti89n	258	2	have	have	VBP
cord-018182-lleti89n	258	3	been	be	VBN
cord-018182-lleti89n	258	4	successfully	successfully	RB
cord-018182-lleti89n	258	5	used	use	VBN
cord-018182-lleti89n	258	6	in	in	IN
cord-018182-lleti89n	258	7	the	the	DT
cord-018182-lleti89n	258	8	treatment	treatment	NN
cord-018182-lleti89n	258	9	of	of	IN
cord-018182-lleti89n	258	10	RV	RV	NNP
cord-018182-lleti89n	258	11	failure	failure	NN
cord-018182-lleti89n	258	12	due	due	JJ
cord-018182-lleti89n	258	13	to	to	IN
cord-018182-lleti89n	258	14	myocardial	myocardial	JJ
cord-018182-lleti89n	258	15	infarction	infarction	NN
cord-018182-lleti89n	258	16	,	,	,
cord-018182-lleti89n	258	17	cardiopulmonary	cardiopulmonary	JJ
cord-018182-lleti89n	258	18	bypass	bypass	NN
cord-018182-lleti89n	258	19	,	,	,
cord-018182-lleti89n	258	20	left	leave	VBN
cord-018182-lleti89n	258	21	ventricular	ventricular	JJ
cord-018182-lleti89n	258	22	assist	assist	VB
cord-018182-lleti89n	258	23	device	device	NN
cord-018182-lleti89n	258	24	implantation	implantation	NN
cord-018182-lleti89n	258	25	,	,	,
cord-018182-lleti89n	258	26	and	and	CC
cord-018182-lleti89n	258	27	cardiac	cardiac	JJ
cord-018182-lleti89n	258	28	transplant	transplant	NN
cord-018182-lleti89n	258	29	[	[	-LRB-
cord-018182-lleti89n	258	30	29	29	CD
cord-018182-lleti89n	258	31	]	]	-RRB-
cord-018182-lleti89n	258	32	.	.	.
cord-018182-lleti89n	259	1	Extracorporeal	extracorporeal	JJ
cord-018182-lleti89n	259	2	membrane	membrane	NN
cord-018182-lleti89n	259	3	oxygenation	oxygenation	NN
cord-018182-lleti89n	259	4	(	(	-LRB-
cord-018182-lleti89n	259	5	ECMO	ECMO	NNP
cord-018182-lleti89n	259	6	)	)	-RRB-
cord-018182-lleti89n	259	7	has	have	VBZ
cord-018182-lleti89n	259	8	been	be	VBN
cord-018182-lleti89n	259	9	used	use	VBN
cord-018182-lleti89n	259	10	successfully	successfully	RB
cord-018182-lleti89n	259	11	to	to	TO
cord-018182-lleti89n	259	12	treat	treat	VB
cord-018182-lleti89n	259	13	RV	RV	NNP
cord-018182-lleti89n	259	14	failure	failure	NN
cord-018182-lleti89n	259	15	due	due	JJ
cord-018182-lleti89n	259	16	to	to	IN
cord-018182-lleti89n	259	17	massive	massive	JJ
cord-018182-lleti89n	259	18	PE	PE	NNP
cord-018182-lleti89n	259	19	,	,	,
cord-018182-lleti89n	259	20	chronic	chronic	JJ
cord-018182-lleti89n	259	21	thromboembolic	thromboembolic	JJ
cord-018182-lleti89n	259	22	pulmonary	pulmonary	JJ
cord-018182-lleti89n	259	23	hypertension	hypertension	NN
cord-018182-lleti89n	259	24	(	(	-LRB-
cord-018182-lleti89n	259	25	CTEPH	CTEPH	NNP
cord-018182-lleti89n	259	26	)	)	-RRB-
cord-018182-lleti89n	259	27	,	,	,
cord-018182-lleti89n	259	28	and	and	CC
cord-018182-lleti89n	259	29	PAH	PAH	NNP
cord-018182-lleti89n	259	30	as	as	IN
cord-018182-lleti89n	259	31	a	a	DT
cord-018182-lleti89n	259	32	bridge	bridge	NN
cord-018182-lleti89n	259	33	to	to	IN
cord-018182-lleti89n	259	34	endarterectomy	endarterectomy	NN
cord-018182-lleti89n	259	35	or	or	CC
cord-018182-lleti89n	259	36	lung	lung	NN
cord-018182-lleti89n	259	37	transplantation	transplantation	NN
cord-018182-lleti89n	259	38	.	.	.
cord-018182-lleti89n	260	1	Typically	typically	RB
cord-018182-lleti89n	260	2	venoarterial	venoarterial	JJ
cord-018182-lleti89n	260	3	(	(	-LRB-
cord-018182-lleti89n	260	4	VA	VA	NNP
cord-018182-lleti89n	260	5	)	)	-RRB-
cord-018182-lleti89n	260	6	ECMO	ECMO	NNP
cord-018182-lleti89n	260	7	is	be	VBZ
cord-018182-lleti89n	260	8	utilized	utilize	VBN
cord-018182-lleti89n	260	9	to	to	TO
cord-018182-lleti89n	260	10	unload	unload	VB
cord-018182-lleti89n	260	11	the	the	DT
cord-018182-lleti89n	260	12	RV	RV	NNP
cord-018182-lleti89n	260	13	while	while	IN
cord-018182-lleti89n	260	14	maintaining	maintain	VBG
cord-018182-lleti89n	260	15	systemic	systemic	JJ
cord-018182-lleti89n	260	16	oxygenation	oxygenation	NN
cord-018182-lleti89n	260	17	.	.	.
cord-018182-lleti89n	261	1	In	in	IN
cord-018182-lleti89n	261	2	patients	patient	NNS
cord-018182-lleti89n	261	3	with	with	IN
cord-018182-lleti89n	261	4	PAH	PAH	NNP
cord-018182-lleti89n	261	5	,	,	,
cord-018182-lleti89n	261	6	it	-PRON-	PRP
cord-018182-lleti89n	261	7	may	may	MD
cord-018182-lleti89n	261	8	also	also	RB
cord-018182-lleti89n	261	9	be	be	VB
cord-018182-lleti89n	261	10	used	use	VBN
cord-018182-lleti89n	261	11	to	to	TO
cord-018182-lleti89n	261	12	support	support	VB
cord-018182-lleti89n	261	13	the	the	DT
cord-018182-lleti89n	261	14	RV	RV	NNP
cord-018182-lleti89n	261	15	during	during	IN
cord-018182-lleti89n	261	16	initiation	initiation	NN
cord-018182-lleti89n	261	17	of	of	IN
cord-018182-lleti89n	261	18	pulmonary	pulmonary	JJ
cord-018182-lleti89n	261	19	vasodilator	vasodilator	NN
cord-018182-lleti89n	261	20	therapy	therapy	NN
cord-018182-lleti89n	261	21	.	.	.
cord-018182-lleti89n	262	1	However	however	RB
cord-018182-lleti89n	262	2	,	,	,
cord-018182-lleti89n	262	3	complications	complication	NNS
cord-018182-lleti89n	262	4	including	include	VBG
cord-018182-lleti89n	262	5	hemorrhage	hemorrhage	NN
cord-018182-lleti89n	262	6	,	,	,
cord-018182-lleti89n	262	7	infection	infection	NN
cord-018182-lleti89n	262	8	,	,	,
cord-018182-lleti89n	262	9	anemia	anemia	NN
cord-018182-lleti89n	262	10	,	,	,
cord-018182-lleti89n	262	11	thrombocytopenia	thrombocytopenia	NN
cord-018182-lleti89n	262	12	,	,	,
cord-018182-lleti89n	262	13	thromboembolism	thromboembolism	NN
cord-018182-lleti89n	262	14	,	,	,
cord-018182-lleti89n	262	15	and	and	CC
cord-018182-lleti89n	262	16	neurologic	neurologic	JJ
cord-018182-lleti89n	262	17	sequelae	sequela	NNS
cord-018182-lleti89n	262	18	are	be	VBP
cord-018182-lleti89n	262	19	possible	possible	JJ
cord-018182-lleti89n	262	20	[	[	-LRB-
cord-018182-lleti89n	262	21	28	28	CD
cord-018182-lleti89n	262	22	]	]	-RRB-
cord-018182-lleti89n	262	23	.	.	.
cord-018182-lleti89n	263	1	Percutaneous	percutaneous	JJ
cord-018182-lleti89n	263	2	interventions	intervention	NNS
cord-018182-lleti89n	263	3	such	such	JJ
cord-018182-lleti89n	263	4	as	as	IN
cord-018182-lleti89n	263	5	balloon	balloon	NN
cord-018182-lleti89n	263	6	atrioseptostomy	atrioseptostomy	NN
cord-018182-lleti89n	263	7	(	(	-LRB-
cord-018182-lleti89n	263	8	BAS	BAS	NNP
cord-018182-lleti89n	263	9	)	)	-RRB-
cord-018182-lleti89n	263	10	may	may	MD
cord-018182-lleti89n	263	11	be	be	VB
cord-018182-lleti89n	263	12	used	use	VBN
cord-018182-lleti89n	263	13	as	as	IN
cord-018182-lleti89n	263	14	either	either	CC
cord-018182-lleti89n	263	15	a	a	DT
cord-018182-lleti89n	263	16	bridge	bridge	NN
cord-018182-lleti89n	263	17	to	to	IN
cord-018182-lleti89n	263	18	lung	lung	NN
cord-018182-lleti89n	263	19	transplantation	transplantation	NN
cord-018182-lleti89n	263	20	or	or	CC
cord-018182-lleti89n	263	21	as	as	IN
cord-018182-lleti89n	263	22	palliative	palliative	JJ
cord-018182-lleti89n	263	23	therapy	therapy	NN
cord-018182-lleti89n	263	24	.	.	.
cord-018182-lleti89n	264	1	The	the	DT
cord-018182-lleti89n	264	2	procedure	procedure	NN
cord-018182-lleti89n	264	3	works	work	VBZ
cord-018182-lleti89n	264	4	by	by	IN
cord-018182-lleti89n	264	5	creating	create	VBG
cord-018182-lleti89n	264	6	an	an	DT
cord-018182-lleti89n	264	7	atrial	atrial	JJ
cord-018182-lleti89n	264	8	level	level	NN
cord-018182-lleti89n	264	9	right	right	NN
cord-018182-lleti89n	264	10	-	-	HYPH
cord-018182-lleti89n	264	11	to	to	IN
cord-018182-lleti89n	264	12	-	-	HYPH
cord-018182-lleti89n	264	13	left	left	JJ
cord-018182-lleti89n	264	14	shunt	shunt	NN
cord-018182-lleti89n	264	15	that	that	WDT
cord-018182-lleti89n	264	16	bypasses	bypass	VBZ
cord-018182-lleti89n	264	17	the	the	DT
cord-018182-lleti89n	264	18	obstructed	obstruct	VBN
cord-018182-lleti89n	264	19	pulmonary	pulmonary	JJ
cord-018182-lleti89n	264	20	circulation	circulation	NN
cord-018182-lleti89n	264	21	,	,	,
cord-018182-lleti89n	264	22	allowing	allow	VBG
cord-018182-lleti89n	264	23	for	for	IN
cord-018182-lleti89n	264	24	improved	improved	JJ
cord-018182-lleti89n	264	25	LV	LV	NNP
cord-018182-lleti89n	264	26	filling	fill	VBG
cord-018182-lleti89n	264	27	,	,	,
cord-018182-lleti89n	264	28	systemic	systemic	JJ
cord-018182-lleti89n	264	29	oxygenation	oxygenation	NN
cord-018182-lleti89n	264	30	,	,	,
cord-018182-lleti89n	264	31	and	and	CC
cord-018182-lleti89n	264	32	blood	blood	NN
cord-018182-lleti89n	264	33	flow	flow	NN
cord-018182-lleti89n	264	34	.	.	.
cord-018182-lleti89n	265	1	However	however	RB
cord-018182-lleti89n	265	2	,	,	,
cord-018182-lleti89n	265	3	its	-PRON-	PRP$
cord-018182-lleti89n	265	4	use	use	NN
cord-018182-lleti89n	265	5	as	as	IN
cord-018182-lleti89n	265	6	an	an	DT
cord-018182-lleti89n	265	7	emergent	emergent	JJ
cord-018182-lleti89n	265	8	rescue	rescue	NN
cord-018182-lleti89n	265	9	therapy	therapy	NN
cord-018182-lleti89n	265	10	is	be	VBZ
cord-018182-lleti89n	265	11	not	not	RB
cord-018182-lleti89n	265	12	recommended	recommend	VBN
cord-018182-lleti89n	265	13	given	give	VBN
cord-018182-lleti89n	265	14	the	the	DT
cord-018182-lleti89n	265	15	high	high	JJ
cord-018182-lleti89n	265	16	risk	risk	NN
cord-018182-lleti89n	265	17	for	for	IN
cord-018182-lleti89n	265	18	fatal	fatal	JJ
cord-018182-lleti89n	265	19	complications	complication	NNS
cord-018182-lleti89n	265	20	in	in	IN
cord-018182-lleti89n	265	21	patients	patient	NNS
cord-018182-lleti89n	265	22	with	with	IN
cord-018182-lleti89n	265	23	markedly	markedly	RB
cord-018182-lleti89n	265	24	elevated	elevated	JJ
cord-018182-lleti89n	265	25	RV	rv	NN
cord-018182-lleti89n	265	26	filling	filling	NN
cord-018182-lleti89n	265	27	pressures	pressure	NNS
cord-018182-lleti89n	265	28	and/or	and/or	CC
cord-018182-lleti89n	265	29	low	low	JJ
cord-018182-lleti89n	265	30	oxygen	oxygen	NN
cord-018182-lleti89n	265	31	saturations	saturation	NNS
cord-018182-lleti89n	265	32	[	[	-LRB-
cord-018182-lleti89n	265	33	32	32	CD
cord-018182-lleti89n	265	34	,	,	,
cord-018182-lleti89n	265	35	33	33	CD
cord-018182-lleti89n	265	36	]	]	-RRB-
cord-018182-lleti89n	265	37	.	.	.
cord-018182-lleti89n	266	1	Lung	lung	NN
cord-018182-lleti89n	266	2	and	and	CC
cord-018182-lleti89n	266	3	or	or	CC
cord-018182-lleti89n	266	4	heart	heart	NN
cord-018182-lleti89n	266	5	-	-	HYPH
cord-018182-lleti89n	266	6	lung	lung	NN
cord-018182-lleti89n	266	7	transplantation	transplantation	NN
cord-018182-lleti89n	266	8	is	be	VBZ
cord-018182-lleti89n	266	9	an	an	DT
cord-018182-lleti89n	266	10	important	important	JJ
cord-018182-lleti89n	266	11	treatment	treatment	NN
cord-018182-lleti89n	266	12	option	option	NN
cord-018182-lleti89n	266	13	for	for	IN
cord-018182-lleti89n	266	14	patients	patient	NNS
cord-018182-lleti89n	266	15	with	with	IN
cord-018182-lleti89n	266	16	progressive	progressive	JJ
cord-018182-lleti89n	266	17	PH	PH	NNP
cord-018182-lleti89n	266	18	,	,	,
cord-018182-lleti89n	266	19	particularly	particularly	RB
cord-018182-lleti89n	266	20	in	in	IN
cord-018182-lleti89n	266	21	the	the	DT
cord-018182-lleti89n	266	22	presence	presence	NN
cord-018182-lleti89n	266	23	of	of	IN
cord-018182-lleti89n	266	24	RV	RV	NNP
cord-018182-lleti89n	266	25	failure	failure	NN
cord-018182-lleti89n	266	26	.	.	.
cord-018182-lleti89n	267	1	Bilateral	bilateral	JJ
cord-018182-lleti89n	267	2	lung	lung	NN
cord-018182-lleti89n	267	3	transplantation	transplantation	NN
cord-018182-lleti89n	267	4	may	may	MD
cord-018182-lleti89n	267	5	be	be	VB
cord-018182-lleti89n	267	6	considered	consider	VBN
cord-018182-lleti89n	267	7	in	in	IN
cord-018182-lleti89n	267	8	select	select	JJ
cord-018182-lleti89n	267	9	cases	case	NNS
cord-018182-lleti89n	267	10	with	with	IN
cord-018182-lleti89n	267	11	dual	dual	JJ
cord-018182-lleti89n	267	12	heart	heart	NN
cord-018182-lleti89n	267	13	-	-	HYPH
cord-018182-lleti89n	267	14	lung	lung	NN
cord-018182-lleti89n	267	15	transplant	transplant	NN
cord-018182-lleti89n	267	16	reserved	reserve	VBN
cord-018182-lleti89n	267	17	for	for	IN
cord-018182-lleti89n	267	18	selected	select	VBN
cord-018182-lleti89n	267	19	patients	patient	NNS
cord-018182-lleti89n	267	20	with	with	IN
cord-018182-lleti89n	267	21	severe	severe	JJ
cord-018182-lleti89n	267	22	irreversible	irreversible	JJ
cord-018182-lleti89n	267	23	PH	ph	NN
cord-018182-lleti89n	267	24	and	and	CC
cord-018182-lleti89n	267	25	concomitant	concomitant	JJ
cord-018182-lleti89n	267	26	severe	severe	JJ
cord-018182-lleti89n	267	27	cardiac	cardiac	JJ
cord-018182-lleti89n	267	28	disease	disease	NN
cord-018182-lleti89n	267	29	.	.	.
cord-018182-lleti89n	268	1	Indications	indication	NNS
cord-018182-lleti89n	268	2	and	and	CC
cord-018182-lleti89n	268	3	contraindications	contraindication	NNS
cord-018182-lleti89n	268	4	for	for	IN
cord-018182-lleti89n	268	5	transplant	transplant	NN
cord-018182-lleti89n	268	6	will	will	MD
cord-018182-lleti89n	268	7	not	not	RB
cord-018182-lleti89n	268	8	be	be	VB
cord-018182-lleti89n	268	9	reviewed	review	VBN
cord-018182-lleti89n	268	10	herein	herein	RB
cord-018182-lleti89n	268	11	as	as	IN
cord-018182-lleti89n	268	12	its	-PRON-	PRP$
cord-018182-lleti89n	268	13	consideration	consideration	NN
cord-018182-lleti89n	268	14	is	be	VBZ
cord-018182-lleti89n	268	15	complex	complex	JJ
cord-018182-lleti89n	268	16	and	and	CC
cord-018182-lleti89n	268	17	uncommon	uncommon	JJ
cord-018182-lleti89n	268	18	in	in	IN
cord-018182-lleti89n	268	19	the	the	DT
cord-018182-lleti89n	268	20	typical	typical	JJ
cord-018182-lleti89n	268	21	ICU	ICU	NNP
cord-018182-lleti89n	268	22	setting	set	VBG
cord-018182-lleti89n	268	23	[	[	-LRB-
cord-018182-lleti89n	268	24	32	32	CD
cord-018182-lleti89n	268	25	,	,	,
cord-018182-lleti89n	268	26	33	33	CD
cord-018182-lleti89n	268	27	]	]	-RRB-
cord-018182-lleti89n	268	28	.	.	.
cord-018182-lleti89n	269	1	Patients	patient	NNS
cord-018182-lleti89n	269	2	with	with	IN
cord-018182-lleti89n	269	3	end	end	NN
cord-018182-lleti89n	269	4	-	-	HYPH
cord-018182-lleti89n	269	5	stage	stage	NN
cord-018182-lleti89n	269	6	RVF	RVF	NNS
cord-018182-lleti89n	269	7	who	who	WP
cord-018182-lleti89n	269	8	are	be	VBP
cord-018182-lleti89n	269	9	refractory	refractory	JJ
cord-018182-lleti89n	269	10	to	to	IN
cord-018182-lleti89n	269	11	medical	medical	JJ
cord-018182-lleti89n	269	12	therapy	therapy	NN
cord-018182-lleti89n	269	13	and	and	CC
cord-018182-lleti89n	269	14	not	not	RB
cord-018182-lleti89n	269	15	candidates	candidate	NNS
cord-018182-lleti89n	269	16	for	for	IN
cord-018182-lleti89n	269	17	advanced	advanced	JJ
cord-018182-lleti89n	269	18	therapies	therapy	NNS
cord-018182-lleti89n	269	19	have	have	VBP
cord-018182-lleti89n	269	20	a	a	DT
cord-018182-lleti89n	269	21	poor	poor	JJ
cord-018182-lleti89n	269	22	prognosis	prognosis	NN
cord-018182-lleti89n	269	23	and	and	CC
cord-018182-lleti89n	269	24	are	be	VBP
cord-018182-lleti89n	269	25	unlikely	unlikely	JJ
cord-018182-lleti89n	269	26	to	to	TO
cord-018182-lleti89n	269	27	survive	survive	VB
cord-018182-lleti89n	269	28	cardiac	cardiac	JJ
cord-018182-lleti89n	269	29	arrest	arrest	NN
cord-018182-lleti89n	269	30	.	.	.
cord-018182-lleti89n	270	1	Therefore	therefore	RB
cord-018182-lleti89n	270	2	,	,	,
cord-018182-lleti89n	270	3	in	in	IN
cord-018182-lleti89n	270	4	patients	patient	NNS
cord-018182-lleti89n	270	5	with	with	IN
cord-018182-lleti89n	270	6	PH	PH	NNP
cord-018182-lleti89n	270	7	and	and	CC
cord-018182-lleti89n	270	8	RV	RV	NNP
cord-018182-lleti89n	270	9	dysfunction	dysfunction	NN
cord-018182-lleti89n	270	10	,	,	,
cord-018182-lleti89n	270	11	early	early	JJ
cord-018182-lleti89n	270	12	conversations	conversation	NNS
cord-018182-lleti89n	270	13	regarding	regard	VBG
cord-018182-lleti89n	270	14	patient	patient	JJ
cord-018182-lleti89n	270	15	preferences	preference	NNS
cord-018182-lleti89n	270	16	and	and	CC
cord-018182-lleti89n	270	17	goals	goal	NNS
cord-018182-lleti89n	270	18	of	of	IN
cord-018182-lleti89n	270	19	care	care	NN
cord-018182-lleti89n	270	20	are	be	VBP
cord-018182-lleti89n	270	21	essential	essential	JJ
cord-018182-lleti89n	270	22	,	,	,
cord-018182-lleti89n	270	23	particularly	particularly	RB
cord-018182-lleti89n	270	24	in	in	IN
cord-018182-lleti89n	270	25	the	the	DT
cord-018182-lleti89n	270	26	ICU	ICU	NNP
cord-018182-lleti89n	270	27	setting	setting	NN
cord-018182-lleti89n	270	28	.	.	.
cord-018182-lleti89n	271	1	Recommendations	recommendation	NNS
cord-018182-lleti89n	271	2	for	for	IN
cord-018182-lleti89n	271	3	limiting	limit	VBG
cord-018182-lleti89n	271	4	life	life	NN
cord-018182-lleti89n	271	5	-	-	HYPH
cord-018182-lleti89n	271	6	sustaining	sustain	VBG
cord-018182-lleti89n	271	7	therapies	therapy	NNS
cord-018182-lleti89n	271	8	may	may	MD
cord-018182-lleti89n	271	9	be	be	VB
cord-018182-lleti89n	271	10	appropriate	appropriate	JJ
cord-018182-lleti89n	271	11	.	.	.
cord-018182-lleti89n	272	1	Palliative	palliative	JJ
cord-018182-lleti89n	272	2	care	care	NN
cord-018182-lleti89n	272	3	and	and	CC
cord-018182-lleti89n	272	4	hospice	hospice	NN
cord-018182-lleti89n	272	5	should	should	MD
cord-018182-lleti89n	272	6	be	be	VB
cord-018182-lleti89n	272	7	considered	consider	VBN
cord-018182-lleti89n	272	8	in	in	IN
cord-018182-lleti89n	272	9	the	the	DT
cord-018182-lleti89n	272	10	correct	correct	JJ
cord-018182-lleti89n	272	11	setting	setting	NN
cord-018182-lleti89n	272	12	.	.	.
cord-018182-lleti89n	273	1	Patients	patient	NNS
cord-018182-lleti89n	273	2	with	with	IN
cord-018182-lleti89n	273	3	pulmonary	pulmonary	JJ
cord-018182-lleti89n	273	4	hypertension	hypertension	NN
cord-018182-lleti89n	273	5	have	have	VBP
cord-018182-lleti89n	273	6	significantly	significantly	RB
cord-018182-lleti89n	273	7	elevated	elevate	VBN
cord-018182-lleti89n	273	8	morbidity	morbidity	NN
cord-018182-lleti89n	273	9	and	and	CC
cord-018182-lleti89n	273	10	mortality	mortality	NN
cord-018182-lleti89n	273	11	associated	associate	VBN
cord-018182-lleti89n	273	12	with	with	IN
cord-018182-lleti89n	273	13	surgery	surgery	NN
cord-018182-lleti89n	273	14	and	and	CC
cord-018182-lleti89n	273	15	anesthesia	anesthesia	NN
cord-018182-lleti89n	273	16	,	,	,
cord-018182-lleti89n	273	17	in	in	IN
cord-018182-lleti89n	273	18	large	large	JJ
cord-018182-lleti89n	273	19	part	part	NN
cord-018182-lleti89n	273	20	due	due	IN
cord-018182-lleti89n	273	21	to	to	IN
cord-018182-lleti89n	273	22	fluid	fluid	JJ
cord-018182-lleti89n	273	23	shifts	shift	NNS
cord-018182-lleti89n	273	24	,	,	,
cord-018182-lleti89n	273	25	mechanical	mechanical	JJ
cord-018182-lleti89n	273	26	ventilation	ventilation	NN
cord-018182-lleti89n	273	27	,	,	,
cord-018182-lleti89n	273	28	and	and	CC
cord-018182-lleti89n	273	29	inflammatory	inflammatory	JJ
cord-018182-lleti89n	273	30	mediator	mediator	NN
cord-018182-lleti89n	273	31	release	release	NN
cord-018182-lleti89n	273	32	that	that	WDT
cord-018182-lleti89n	273	33	results	result	VBZ
cord-018182-lleti89n	273	34	in	in	IN
cord-018182-lleti89n	273	35	the	the	DT
cord-018182-lleti89n	273	36	setting	setting	NN
cord-018182-lleti89n	273	37	of	of	IN
cord-018182-lleti89n	273	38	surgical	surgical	JJ
cord-018182-lleti89n	273	39	interventions	intervention	NNS
cord-018182-lleti89n	273	40	[	[	-LRB-
cord-018182-lleti89n	273	41	33	33	CD
cord-018182-lleti89n	273	42	,	,	,
cord-018182-lleti89n	273	43	36	36	CD
cord-018182-lleti89n	273	44	]	]	-RRB-
cord-018182-lleti89n	273	45	.	.	.
cord-018182-lleti89n	274	1	Both	both	DT
cord-018182-lleti89n	274	2	cardiac	cardiac	NN
cord-018182-lleti89n	274	3	and	and	CC
cord-018182-lleti89n	274	4	noncardiac	noncardiac	JJ
cord-018182-lleti89n	274	5	surgical	surgical	JJ
cord-018182-lleti89n	274	6	patients	patient	NNS
cord-018182-lleti89n	274	7	with	with	IN
cord-018182-lleti89n	274	8	PH	PH	NNP
cord-018182-lleti89n	274	9	have	have	VBP
cord-018182-lleti89n	274	10	higher	high	JJR
cord-018182-lleti89n	274	11	incidences	incidence	NNS
cord-018182-lleti89n	274	12	of	of	IN
cord-018182-lleti89n	274	13	postoperative	postoperative	JJ
cord-018182-lleti89n	274	14	congestive	congestive	JJ
cord-018182-lleti89n	274	15	heart	heart	NN
cord-018182-lleti89n	274	16	failure	failure	NN
cord-018182-lleti89n	274	17	,	,	,
cord-018182-lleti89n	274	18	hemodynamic	hemodynamic	JJ
cord-018182-lleti89n	274	19	instability	instability	NN
cord-018182-lleti89n	274	20	,	,	,
cord-018182-lleti89n	274	21	sepsis	sepsis	NN
cord-018182-lleti89n	274	22	,	,	,
cord-018182-lleti89n	274	23	respiratory	respiratory	JJ
cord-018182-lleti89n	274	24	failure	failure	NN
cord-018182-lleti89n	274	25	,	,	,
cord-018182-lleti89n	274	26	and	and	CC
cord-018182-lleti89n	274	27	in	in	IN
cord-018182-lleti89n	274	28	-	-	HYPH
cord-018182-lleti89n	274	29	hospital	hospital	NN
cord-018182-lleti89n	274	30	death	death	NN
cord-018182-lleti89n	274	31	.	.	.
cord-018182-lleti89n	275	1	Given	give	VBN
cord-018182-lleti89n	275	2	the	the	DT
cord-018182-lleti89n	275	3	associated	associate	VBN
cord-018182-lleti89n	275	4	risks	risk	NNS
cord-018182-lleti89n	275	5	,	,	,
cord-018182-lleti89n	275	6	nonemergent	nonemergent	NN
cord-018182-lleti89n	275	7	surgeries	surgery	NNS
cord-018182-lleti89n	275	8	should	should	MD
cord-018182-lleti89n	275	9	generally	generally	RB
cord-018182-lleti89n	275	10	be	be	VB
cord-018182-lleti89n	275	11	avoided	avoid	VBN
cord-018182-lleti89n	275	12	in	in	IN
cord-018182-lleti89n	275	13	the	the	DT
cord-018182-lleti89n	275	14	setting	setting	NN
cord-018182-lleti89n	275	15	of	of	IN
cord-018182-lleti89n	275	16	PH	ph	NN
cord-018182-lleti89n	275	17	-	-	HYPH
cord-018182-lleti89n	275	18	induced	induce	VBN
cord-018182-lleti89n	275	19	RV	RV	NNP
cord-018182-lleti89n	275	20	failure	failure	NN
cord-018182-lleti89n	275	21	[	[	-LRB-
cord-018182-lleti89n	275	22	37	37	CD
cord-018182-lleti89n	275	23	]	]	-RRB-
cord-018182-lleti89n	275	24	[	[	-LRB-
cord-018182-lleti89n	275	25	38	38	CD
cord-018182-lleti89n	275	26	]	]	-RRB-
cord-018182-lleti89n	275	27	[	[	-LRB-
cord-018182-lleti89n	275	28	39	39	CD
cord-018182-lleti89n	275	29	]	]	-RRB-
cord-018182-lleti89n	275	30	.	.	.
cord-018182-lleti89n	276	1	Standards	standard	NNS
cord-018182-lleti89n	276	2	for	for	IN
cord-018182-lleti89n	276	3	the	the	DT
cord-018182-lleti89n	276	4	diagnosis	diagnosis	NN
cord-018182-lleti89n	276	5	and	and	CC
cord-018182-lleti89n	276	6	treatment	treatment	NN
cord-018182-lleti89n	276	7	of	of	IN
cord-018182-lleti89n	276	8	patients	patient	NNS
cord-018182-lleti89n	276	9	with	with	IN
cord-018182-lleti89n	276	10	COPD	COPD	NNP
cord-018182-lleti89n	276	11	:	:	:
cord-018182-lleti89n	276	12	a	a	DT
cord-018182-lleti89n	276	13	summary	summary	NN
cord-018182-lleti89n	276	14	of	of	IN
cord-018182-lleti89n	276	15	the	the	DT
cord-018182-lleti89n	276	16	ATS	ATS	NNP
cord-018182-lleti89n	276	17	/	/	SYM
cord-018182-lleti89n	276	18	ERS	ERS	NNP
cord-018182-lleti89n	276	19	position	position	VBP
cord-018182-lleti89n	276	20	paper	paper	NN
cord-018182-lleti89n	276	21	COPD	COPD	NNP
cord-018182-lleti89n	276	22	exacerbations	exacerbation	NNS
cord-018182-lleti89n	276	23	:	:	:
cord-018182-lleti89n	276	24	(	(	-LRB-
cord-018182-lleti89n	276	25	2	2	LS
cord-018182-lleti89n	276	26	)	)	-RRB-
cord-018182-lleti89n	276	27	aetiology	aetiology	NN
cord-018182-lleti89n	276	28	Outcomes	outcome	NNS
cord-018182-lleti89n	276	29	following	follow	VBG
cord-018182-lleti89n	276	30	acute	acute	JJ
cord-018182-lleti89n	276	31	exacerbations	exacerbation	NNS
cord-018182-lleti89n	276	32	of	of	IN
cord-018182-lleti89n	276	33	severe	severe	JJ
cord-018182-lleti89n	276	34	chronic	chronic	JJ
cord-018182-lleti89n	276	35	obstructive	obstructive	JJ
cord-018182-lleti89n	276	36	lung	lung	NN
cord-018182-lleti89n	276	37	disease	disease	NN
cord-018182-lleti89n	276	38	.	.	.
cord-018182-lleti89n	277	1	The	the	DT
cord-018182-lleti89n	277	2	SUPPORT	SUPPORT	NNP
cord-018182-lleti89n	277	3	investigators	investigator	NNS
cord-018182-lleti89n	277	4	(	(	-LRB-
cord-018182-lleti89n	277	5	Study	study	NN
cord-018182-lleti89n	277	6	to	to	TO
cord-018182-lleti89n	277	7	Understand	understand	VB
cord-018182-lleti89n	277	8	Prognoses	Prognoses	NNPS
cord-018182-lleti89n	277	9	and	and	CC
cord-018182-lleti89n	277	10	Preferences	Preferences	NNPS
cord-018182-lleti89n	277	11	for	for	IN
cord-018182-lleti89n	277	12	Outcomes	Outcomes	NNPS
cord-018182-lleti89n	277	13	and	and	CC
cord-018182-lleti89n	277	14	Risks	risk	NNS
cord-018182-lleti89n	277	15	of	of	IN
cord-018182-lleti89n	277	16	Treatments	Treatments	NNP
cord-018182-lleti89n	277	17	)	)	-RRB-
cord-018182-lleti89n	277	18	Hospital	Hospital	NNP
cord-018182-lleti89n	277	19	and	and	CC
cord-018182-lleti89n	277	20	1-year	1-year	CD
cord-018182-lleti89n	277	21	survival	survival	NN
cord-018182-lleti89n	277	22	of	of	IN
cord-018182-lleti89n	277	23	patients	patient	NNS
cord-018182-lleti89n	277	24	admitted	admit	VBN
cord-018182-lleti89n	277	25	to	to	IN
cord-018182-lleti89n	277	26	intensive	intensive	JJ
cord-018182-lleti89n	277	27	care	care	NN
cord-018182-lleti89n	277	28	units	unit	NNS
cord-018182-lleti89n	277	29	with	with	IN
cord-018182-lleti89n	277	30	acute	acute	JJ
cord-018182-lleti89n	277	31	exacerbations	exacerbation	NNS
cord-018182-lleti89n	277	32	of	of	IN
cord-018182-lleti89n	277	33	chronic	chronic	JJ
cord-018182-lleti89n	277	34	obstructive	obstructive	JJ
cord-018182-lleti89n	277	35	pulmonary	pulmonary	JJ
cord-018182-lleti89n	277	36	disease	disease	NN
cord-018182-lleti89n	277	37	Infection	infection	NN
cord-018182-lleti89n	277	38	in	in	IN
cord-018182-lleti89n	277	39	the	the	DT
cord-018182-lleti89n	277	40	pathogenesis	pathogenesis	NN
cord-018182-lleti89n	277	41	and	and	CC
cord-018182-lleti89n	277	42	course	course	NN
cord-018182-lleti89n	277	43	of	of	IN
cord-018182-lleti89n	277	44	chronic	chronic	JJ
cord-018182-lleti89n	277	45	obstructive	obstructive	JJ
cord-018182-lleti89n	277	46	pulmonary	pulmonary	JJ
cord-018182-lleti89n	277	47	disease	disease	NN
cord-018182-lleti89n	277	48	Prevalence	prevalence	NN
cord-018182-lleti89n	277	49	of	of	IN
cord-018182-lleti89n	277	50	viral	viral	JJ
cord-018182-lleti89n	277	51	infection	infection	NN
cord-018182-lleti89n	277	52	detected	detect	VBN
cord-018182-lleti89n	277	53	by	by	IN
cord-018182-lleti89n	277	54	PCR	PCR	NNP
cord-018182-lleti89n	277	55	and	and	CC
cord-018182-lleti89n	277	56	RT	RT	NNP
cord-018182-lleti89n	277	57	-	-	HYPH
cord-018182-lleti89n	277	58	PCR	PCR	NNP
cord-018182-lleti89n	277	59	in	in	IN
cord-018182-lleti89n	277	60	patients	patient	NNS
cord-018182-lleti89n	277	61	with	with	IN
cord-018182-lleti89n	277	62	acute	acute	JJ
cord-018182-lleti89n	277	63	exacerbation	exacerbation	NN
cord-018182-lleti89n	277	64	of	of	IN
cord-018182-lleti89n	277	65	COPD	COPD	NNP
cord-018182-lleti89n	277	66	:	:	:
cord-018182-lleti89n	277	67	a	a	DT
cord-018182-lleti89n	277	68	systematic	systematic	JJ
cord-018182-lleti89n	277	69	review	review	NN
cord-018182-lleti89n	277	70	Pathophysiology	pathophysiology	NN
cord-018182-lleti89n	277	71	of	of	IN
cord-018182-lleti89n	277	72	acute	acute	JJ
cord-018182-lleti89n	277	73	exacerbations	exacerbation	NNS
cord-018182-lleti89n	277	74	of	of	IN
cord-018182-lleti89n	277	75	chronic	chronic	JJ
cord-018182-lleti89n	277	76	obstructive	obstructive	JJ
cord-018182-lleti89n	277	77	pulmonary	pulmonary	JJ
cord-018182-lleti89n	277	78	disease	disease	NN
cord-018182-lleti89n	277	79	Global	global	JJ
cord-018182-lleti89n	277	80	strategy	strategy	NN
cord-018182-lleti89n	277	81	for	for	IN
cord-018182-lleti89n	277	82	the	the	DT
cord-018182-lleti89n	277	83	diagnosis	diagnosis	NN
cord-018182-lleti89n	277	84	,	,	,
cord-018182-lleti89n	277	85	management	management	NN
cord-018182-lleti89n	277	86	and	and	CC
cord-018182-lleti89n	277	87	prevention	prevention	NN
cord-018182-lleti89n	277	88	of	of	IN
cord-018182-lleti89n	277	89	COPD	COPD	NNP
cord-018182-lleti89n	277	90	,	,	,
cord-018182-lleti89n	277	91	Global	Global	NNP
cord-018182-lleti89n	277	92	Initiative	Initiative	NNP
cord-018182-lleti89n	277	93	for	for	IN
cord-018182-lleti89n	277	94	Chronic	Chronic	NNP
cord-018182-lleti89n	277	95	Obstructive	Obstructive	NNP
cord-018182-lleti89n	277	96	Lung	Lung	NNP
cord-018182-lleti89n	277	97	Disease	Disease	NNP
cord-018182-lleti89n	277	98	(	(	-LRB-
cord-018182-lleti89n	277	99	GOLD	gold	NN
cord-018182-lleti89n	277	100	)	)	-RRB-
cord-018182-lleti89n	278	1	Global	global	JJ
cord-018182-lleti89n	278	2	strategy	strategy	NN
cord-018182-lleti89n	278	3	for	for	IN
cord-018182-lleti89n	278	4	the	the	DT
cord-018182-lleti89n	278	5	diagnosis	diagnosis	NN
cord-018182-lleti89n	278	6	,	,	,
cord-018182-lleti89n	278	7	management	management	NN
cord-018182-lleti89n	278	8	and	and	CC
cord-018182-lleti89n	278	9	prevention	prevention	NN
cord-018182-lleti89n	278	10	of	of	IN
cord-018182-lleti89n	278	11	chronic	chronic	JJ
cord-018182-lleti89n	278	12	obstructive	obstructive	JJ
cord-018182-lleti89n	278	13	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	14	disease	disease	NN
cord-018182-lleti89n	278	15	:	:	:
cord-018182-lleti89n	278	16	GOLD	gold	NN
cord-018182-lleti89n	278	17	executive	executive	JJ
cord-018182-lleti89n	278	18	summary	summary	NN
cord-018182-lleti89n	278	19	Validation	validation	NN
cord-018182-lleti89n	278	20	of	of	IN
cord-018182-lleti89n	278	21	a	a	DT
cord-018182-lleti89n	278	22	novel	novel	JJ
cord-018182-lleti89n	278	23	risk	risk	NN
cord-018182-lleti89n	278	24	score	score	NN
cord-018182-lleti89n	278	25	for	for	IN
cord-018182-lleti89n	278	26	severity	severity	NN
cord-018182-lleti89n	278	27	of	of	IN
cord-018182-lleti89n	278	28	illness	illness	NN
cord-018182-lleti89n	278	29	in	in	IN
cord-018182-lleti89n	278	30	acute	acute	JJ
cord-018182-lleti89n	278	31	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	32	of	of	IN
cord-018182-lleti89n	278	33	COPD	COPD	NNP
cord-018182-lleti89n	278	34	Clinical	clinical	JJ
cord-018182-lleti89n	278	35	practice	practice	NN
cord-018182-lleti89n	278	36	:	:	:
cord-018182-lleti89n	278	37	acute	acute	JJ
cord-018182-lleti89n	278	38	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	39	of	of	IN
cord-018182-lleti89n	278	40	chronic	chronic	JJ
cord-018182-lleti89n	278	41	obstructive	obstructive	JJ
cord-018182-lleti89n	278	42	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	43	disease	disease	NN
cord-018182-lleti89n	278	44	Effect	effect	NN
cord-018182-lleti89n	278	45	of	of	IN
cord-018182-lleti89n	278	46	systemic	systemic	JJ
cord-018182-lleti89n	278	47	glucocorticoids	glucocorticoid	NNS
cord-018182-lleti89n	278	48	on	on	IN
cord-018182-lleti89n	278	49	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	50	of	of	IN
cord-018182-lleti89n	278	51	chronic	chronic	JJ
cord-018182-lleti89n	278	52	obstructive	obstructive	JJ
cord-018182-lleti89n	278	53	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	54	disease	disease	NN
cord-018182-lleti89n	278	55	Short	short	JJ
cord-018182-lleti89n	278	56	-	-	HYPH
cord-018182-lleti89n	278	57	term	term	NN
cord-018182-lleti89n	278	58	vs	vs	IN
cord-018182-lleti89n	278	59	conventional	conventional	JJ
cord-018182-lleti89n	278	60	glucocorticoid	glucocorticoid	NN
cord-018182-lleti89n	278	61	therapy	therapy	NN
cord-018182-lleti89n	278	62	in	in	IN
cord-018182-lleti89n	278	63	acute	acute	JJ
cord-018182-lleti89n	278	64	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	65	of	of	IN
cord-018182-lleti89n	278	66	chronic	chronic	JJ
cord-018182-lleti89n	278	67	obstructive	obstructive	JJ
cord-018182-lleti89n	278	68	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	69	disease	disease	NN
cord-018182-lleti89n	278	70	:	:	:
cord-018182-lleti89n	278	71	the	the	DT
cord-018182-lleti89n	278	72	REDUCE	reduce	NN
cord-018182-lleti89n	278	73	randomized	randomize	VBN
cord-018182-lleti89n	278	74	clinical	clinical	JJ
cord-018182-lleti89n	278	75	trial	trial	NN
cord-018182-lleti89n	278	76	Acute	acute	JJ
cord-018182-lleti89n	278	77	respiratory	respiratory	JJ
cord-018182-lleti89n	278	78	failure	failure	NN
cord-018182-lleti89n	278	79	due	due	JJ
cord-018182-lleti89n	278	80	to	to	IN
cord-018182-lleti89n	278	81	chronic	chronic	JJ
cord-018182-lleti89n	278	82	obstructive	obstructive	JJ
cord-018182-lleti89n	278	83	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	84	disease	disease	NN
cord-018182-lleti89n	278	85	Exacerbations	Exacerbations	NNPS
cord-018182-lleti89n	278	86	of	of	IN
cord-018182-lleti89n	278	87	chronic	chronic	JJ
cord-018182-lleti89n	278	88	obstructive	obstructive	JJ
cord-018182-lleti89n	278	89	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	90	disease	disease	NN
cord-018182-lleti89n	278	91	Contemporary	contemporary	JJ
cord-018182-lleti89n	278	92	management	management	NN
cord-018182-lleti89n	278	93	of	of	IN
cord-018182-lleti89n	278	94	acute	acute	JJ
cord-018182-lleti89n	278	95	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	96	of	of	IN
cord-018182-lleti89n	278	97	COPD	COPD	NNP
cord-018182-lleti89n	278	98	:	:	:
cord-018182-lleti89n	278	99	a	a	DT
cord-018182-lleti89n	278	100	systematic	systematic	JJ
cord-018182-lleti89n	278	101	review	review	NN
cord-018182-lleti89n	278	102	and	and	CC
cord-018182-lleti89n	278	103	meta	meta	NNP
cord-018182-lleti89n	278	104	-	-	HYPH
cord-018182-lleti89n	278	105	analysis	analysis	NN
cord-018182-lleti89n	278	106	Antibiotic	antibiotic	JJ
cord-018182-lleti89n	278	107	therapy	therapy	NN
cord-018182-lleti89n	278	108	and	and	CC
cord-018182-lleti89n	278	109	treatment	treatment	NN
cord-018182-lleti89n	278	110	failure	failure	NN
cord-018182-lleti89n	278	111	in	in	IN
cord-018182-lleti89n	278	112	patients	patient	NNS
cord-018182-lleti89n	278	113	hospitalized	hospitalize	VBN
cord-018182-lleti89n	278	114	for	for	IN
cord-018182-lleti89n	278	115	acute	acute	JJ
cord-018182-lleti89n	278	116	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	117	of	of	IN
cord-018182-lleti89n	278	118	chronic	chronic	JJ
cord-018182-lleti89n	278	119	obstructive	obstructive	JJ
cord-018182-lleti89n	278	120	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	121	disease	disease	NNP
cord-018182-lleti89n	278	122	Association	Association	NNP
cord-018182-lleti89n	278	123	between	between	IN
cord-018182-lleti89n	278	124	antibiotic	antibiotic	JJ
cord-018182-lleti89n	278	125	treatment	treatment	NN
cord-018182-lleti89n	278	126	and	and	CC
cord-018182-lleti89n	278	127	outcomes	outcome	NNS
cord-018182-lleti89n	278	128	in	in	IN
cord-018182-lleti89n	278	129	patients	patient	NNS
cord-018182-lleti89n	278	130	hospitalized	hospitalize	VBN
cord-018182-lleti89n	278	131	with	with	IN
cord-018182-lleti89n	278	132	acute	acute	JJ
cord-018182-lleti89n	278	133	exacerbation	exacerbation	NN
cord-018182-lleti89n	278	134	of	of	IN
cord-018182-lleti89n	278	135	COPD	COPD	NNP
cord-018182-lleti89n	278	136	treated	treat	VBN
cord-018182-lleti89n	278	137	with	with	IN
cord-018182-lleti89n	278	138	systemic	systemic	JJ
cord-018182-lleti89n	278	139	steroids	steroid	NNS
cord-018182-lleti89n	278	140	Antibiotic	antibiotic	JJ
cord-018182-lleti89n	278	141	therapy	therapy	NN
cord-018182-lleti89n	278	142	in	in	IN
cord-018182-lleti89n	278	143	exacerbations	exacerbation	NNS
cord-018182-lleti89n	278	144	of	of	IN
cord-018182-lleti89n	278	145	chronic	chronic	JJ
cord-018182-lleti89n	278	146	obstructive	obstructive	JJ
cord-018182-lleti89n	278	147	pulmonary	pulmonary	JJ
cord-018182-lleti89n	278	148	disease	disease	NN
cord-018182-lleti89n	279	1	Once	once	IN
cord-018182-lleti89n	279	2	daily	daily	JJ
cord-018182-lleti89n	279	3	ofloxacin	ofloxacin	NNS
cord-018182-lleti89n	279	4	in	in	IN
cord-018182-lleti89n	279	5	chronic	chronic	JJ
cord-018182-lleti89n	279	6	obstructive	obstructive	JJ
cord-018182-lleti89n	279	7	pulmonary	pulmonary	JJ
cord-018182-lleti89n	279	8	disease	disease	NN
cord-018182-lleti89n	279	9	exacerbation	exacerbation	NN
cord-018182-lleti89n	279	10	requiring	require	VBG
cord-018182-lleti89n	279	11	mechanical	mechanical	JJ
cord-018182-lleti89n	279	12	ventilation	ventilation	NN
cord-018182-lleti89n	279	13	:	:	:
cord-018182-lleti89n	279	14	a	a	DT
cord-018182-lleti89n	279	15	randomized	randomized	JJ
cord-018182-lleti89n	279	16	placebo	placebo	NN
cord-018182-lleti89n	279	17	-	-	HYPH
cord-018182-lleti89n	279	18	controlled	control	VBN
cord-018182-lleti89n	279	19	trial	trial	NN
cord-018182-lleti89n	279	20	Non	non	JJ
cord-018182-lleti89n	279	21	-	-	JJ
cord-018182-lleti89n	279	22	invasive	invasive	JJ
cord-018182-lleti89n	279	23	ventilation	ventilation	NN
cord-018182-lleti89n	279	24	in	in	IN
cord-018182-lleti89n	279	25	acute	acute	JJ
cord-018182-lleti89n	279	26	respiratory	respiratory	JJ
cord-018182-lleti89n	279	27	failure	failure	NN
cord-018182-lleti89n	279	28	Noninvasive	noninvasive	JJ
cord-018182-lleti89n	279	29	positive	positive	JJ
cord-018182-lleti89n	279	30	pressure	pressure	NN
cord-018182-lleti89n	279	31	ventilation	ventilation	NN
cord-018182-lleti89n	279	32	in	in	IN
cord-018182-lleti89n	279	33	the	the	DT
cord-018182-lleti89n	279	34	setting	setting	NN
cord-018182-lleti89n	279	35	of	of	IN
cord-018182-lleti89n	279	36	severe	severe	JJ
cord-018182-lleti89n	279	37	acute	acute	JJ
cord-018182-lleti89n	279	38	exacerbations	exacerbation	NNS
cord-018182-lleti89n	279	39	of	of	IN
cord-018182-lleti89n	279	40	chronic	chronic	JJ
cord-018182-lleti89n	279	41	obstructive	obstructive	JJ
cord-018182-lleti89n	279	42	pulmonary	pulmonary	JJ
cord-018182-lleti89n	279	43	disease	disease	NN
cord-018182-lleti89n	279	44	:	:	:
cord-018182-lleti89n	279	45	more	more	RBR
cord-018182-lleti89n	279	46	effective	effective	JJ
cord-018182-lleti89n	279	47	and	and	CC
cord-018182-lleti89n	279	48	less	less	RBR
cord-018182-lleti89n	279	49	expensive	expensive	JJ
cord-018182-lleti89n	279	50	Does	do	VBZ
cord-018182-lleti89n	279	51	noninvasive	noninvasive	JJ
cord-018182-lleti89n	279	52	positive	positive	JJ
cord-018182-lleti89n	279	53	pressure	pressure	NN
cord-018182-lleti89n	279	54	ventilation	ventilation	NN
cord-018182-lleti89n	279	55	improve	improve	VB
cord-018182-lleti89n	279	56	outcome	outcome	NN
cord-018182-lleti89n	279	57	in	in	IN
cord-018182-lleti89n	279	58	acute	acute	JJ
cord-018182-lleti89n	279	59	hypoxemic	hypoxemic	JJ
cord-018182-lleti89n	279	60	respiratory	respiratory	JJ
cord-018182-lleti89n	279	61	failure	failure	NN
cord-018182-lleti89n	279	62	?	?	.
cord-018182-lleti89n	280	1	A	a	DT
cord-018182-lleti89n	280	2	systematic	systematic	JJ
cord-018182-lleti89n	280	3	review	review	NN
cord-018182-lleti89n	281	1	A	a	DT
cord-018182-lleti89n	281	2	chart	chart	NN
cord-018182-lleti89n	281	3	of	of	IN
cord-018182-lleti89n	281	4	failure	failure	NN
cord-018182-lleti89n	281	5	risk	risk	NN
cord-018182-lleti89n	281	6	for	for	IN
cord-018182-lleti89n	281	7	noninvasive	noninvasive	JJ
cord-018182-lleti89n	281	8	ventilation	ventilation	NN
cord-018182-lleti89n	281	9	in	in	IN
cord-018182-lleti89n	281	10	patients	patient	NNS
cord-018182-lleti89n	281	11	with	with	IN
cord-018182-lleti89n	281	12	COPD	COPD	NNP
cord-018182-lleti89n	281	13	exacerbation	exacerbation	NN
cord-018182-lleti89n	281	14	Auto	Auto	NNP
cord-018182-lleti89n	281	15	-	-	HYPH
cord-018182-lleti89n	281	16	positive	positive	JJ
cord-018182-lleti89n	281	17	endexpiratory	endexpiratory	NN
cord-018182-lleti89n	281	18	pressure	pressure	NN
cord-018182-lleti89n	281	19	:	:	:
cord-018182-lleti89n	282	1	mechanisms	mechanism	NNS
cord-018182-lleti89n	282	2	and	and	CC
cord-018182-lleti89n	282	3	treatment	treatment	NN
cord-018182-lleti89n	282	4	Management	management	NN
cord-018182-lleti89n	282	5	of	of	IN
cord-018182-lleti89n	282	6	pulmonary	pulmonary	JJ
cord-018182-lleti89n	282	7	arterial	arterial	JJ
cord-018182-lleti89n	282	8	hypertension	hypertension	NN
cord-018182-lleti89n	282	9	Updated	update	VBN
cord-018182-lleti89n	282	10	classification	classification	NN
cord-018182-lleti89n	282	11	of	of	IN
cord-018182-lleti89n	282	12	pulmonary	pulmonary	JJ
cord-018182-lleti89n	282	13	hypertension	hypertension	NN
cord-018182-lleti89n	282	14	Management	Management	NNP
cord-018182-lleti89n	282	15	of	of	IN
cord-018182-lleti89n	282	16	acute	acute	JJ
cord-018182-lleti89n	282	17	right	right	JJ
cord-018182-lleti89n	282	18	heart	heart	NN
cord-018182-lleti89n	282	19	failure	failure	NN
cord-018182-lleti89n	282	20	in	in	IN
cord-018182-lleti89n	282	21	the	the	DT
cord-018182-lleti89n	282	22	intensive	intensive	JJ
cord-018182-lleti89n	282	23	care	care	NN
cord-018182-lleti89n	282	24	unit	unit	NN
cord-018182-lleti89n	282	25	Management	Management	NNP
cord-018182-lleti89n	282	26	of	of	IN
cord-018182-lleti89n	282	27	acute	acute	JJ
cord-018182-lleti89n	282	28	right	right	JJ
cord-018182-lleti89n	282	29	heart	heart	NN
cord-018182-lleti89n	282	30	failure	failure	NN
cord-018182-lleti89n	282	31	in	in	IN
cord-018182-lleti89n	282	32	the	the	DT
cord-018182-lleti89n	282	33	intensive	intensive	JJ
cord-018182-lleti89n	282	34	care	care	NN
cord-018182-lleti89n	282	35	unit	unit	NN
cord-018182-lleti89n	282	36	Prognostic	prognostic	JJ
cord-018182-lleti89n	282	37	factors	factor	NNS
cord-018182-lleti89n	282	38	and	and	CC
cord-018182-lleti89n	282	39	outcomes	outcome	NNS
cord-018182-lleti89n	282	40	of	of	IN
cord-018182-lleti89n	282	41	patients	patient	NNS
cord-018182-lleti89n	282	42	with	with	IN
cord-018182-lleti89n	282	43	pulmonary	pulmonary	JJ
cord-018182-lleti89n	282	44	hypertension	hypertension	NN
cord-018182-lleti89n	282	45	admitted	admit	VBN
cord-018182-lleti89n	282	46	to	to	IN
cord-018182-lleti89n	282	47	the	the	DT
cord-018182-lleti89n	282	48	intensive	intensive	JJ
cord-018182-lleti89n	282	49	care	care	NN
cord-018182-lleti89n	282	50	unit	unit	NN
cord-018182-lleti89n	282	51	Prognostic	prognostic	JJ
cord-018182-lleti89n	282	52	factors	factor	NNS
cord-018182-lleti89n	282	53	of	of	IN
cord-018182-lleti89n	282	54	acute	acute	JJ
cord-018182-lleti89n	282	55	heart	heart	NN
cord-018182-lleti89n	282	56	failure	failure	NN
cord-018182-lleti89n	282	57	in	in	IN
cord-018182-lleti89n	282	58	patients	patient	NNS
cord-018182-lleti89n	282	59	with	with	IN
cord-018182-lleti89n	282	60	pulmonary	pulmonary	JJ
cord-018182-lleti89n	282	61	arterial	arterial	JJ
cord-018182-lleti89n	282	62	hypertension	hypertension	NN
cord-018182-lleti89n	282	63	Intensive	Intensive	NNP
cord-018182-lleti89n	282	64	care	care	NN
cord-018182-lleti89n	282	65	unit	unit	NN
cord-018182-lleti89n	282	66	management	management	NN
cord-018182-lleti89n	282	67	of	of	IN
cord-018182-lleti89n	282	68	patients	patient	NNS
cord-018182-lleti89n	282	69	with	with	IN
cord-018182-lleti89n	282	70	severe	severe	JJ
cord-018182-lleti89n	282	71	pulmonary	pulmonary	JJ
cord-018182-lleti89n	282	72	hypertension	hypertension	NN
cord-018182-lleti89n	282	73	and	and	CC
cord-018182-lleti89n	282	74	right	right	JJ
cord-018182-lleti89n	282	75	heart	heart	NN
cord-018182-lleti89n	282	76	failure	failure	NN
cord-018182-lleti89n	283	1	Pulmonary	pulmonary	JJ
cord-018182-lleti89n	283	2	hypertension	hypertension	NN
cord-018182-lleti89n	283	3	in	in	IN
cord-018182-lleti89n	283	4	the	the	DT
cord-018182-lleti89n	283	5	intensive	intensive	JJ
cord-018182-lleti89n	283	6	care	care	NN
cord-018182-lleti89n	283	7	unit	unit	NN
cord-018182-lleti89n	284	1	A	a	DT
cord-018182-lleti89n	284	2	comparison	comparison	NN
cord-018182-lleti89n	284	3	of	of	IN
cord-018182-lleti89n	284	4	continuous	continuous	JJ
cord-018182-lleti89n	284	5	intravenous	intravenous	JJ
cord-018182-lleti89n	284	6	epoprostenol	epoprostenol	NN
cord-018182-lleti89n	284	7	(	(	-LRB-
cord-018182-lleti89n	284	8	prostacyclin	prostacyclin	NNP
cord-018182-lleti89n	284	9	)	)	-RRB-
cord-018182-lleti89n	284	10	with	with	IN
cord-018182-lleti89n	284	11	conventional	conventional	JJ
cord-018182-lleti89n	284	12	therapy	therapy	NN
cord-018182-lleti89n	284	13	for	for	IN
cord-018182-lleti89n	284	14	primary	primary	JJ
cord-018182-lleti89n	284	15	pulmonary	pulmonary	JJ
cord-018182-lleti89n	284	16	hypertension	hypertension	NN
cord-018182-lleti89n	284	17	Management	Management	NNP
cord-018182-lleti89n	284	18	of	of	IN
cord-018182-lleti89n	284	19	severe	severe	JJ
cord-018182-lleti89n	284	20	pulmonary	pulmonary	JJ
cord-018182-lleti89n	284	21	arterial	arterial	JJ
cord-018182-lleti89n	284	22	hypertension	hypertension	NN
cord-018182-lleti89n	285	1	Pulmonary	pulmonary	JJ
cord-018182-lleti89n	285	2	hypertension	hypertension	NN
cord-018182-lleti89n	285	3	and	and	CC
cord-018182-lleti89n	285	4	major	major	JJ
cord-018182-lleti89n	285	5	surgery	surgery	NN
cord-018182-lleti89n	285	6	Pulmonary	pulmonary	JJ
cord-018182-lleti89n	285	7	hypertension	hypertension	NN
cord-018182-lleti89n	285	8	:	:	:
cord-018182-lleti89n	285	9	an	an	DT
cord-018182-lleti89n	285	10	important	important	JJ
cord-018182-lleti89n	285	11	predictor	predictor	NN
cord-018182-lleti89n	285	12	of	of	IN
cord-018182-lleti89n	285	13	outcomes	outcome	NNS
cord-018182-lleti89n	285	14	in	in	IN
cord-018182-lleti89n	285	15	patients	patient	NNS
cord-018182-lleti89n	285	16	undergoing	undergo	VBG
cord-018182-lleti89n	285	17	noncardiac	noncardiac	NNP
cord-018182-lleti89n	285	18	surgery	surgery	NN
cord-018182-lleti89n	285	19	Severe	severe	JJ
cord-018182-lleti89n	285	20	pulmonary	pulmonary	JJ
cord-018182-lleti89n	285	21	hypertension	hypertension	NN
cord-018182-lleti89n	285	22	complicated	complicated	JJ
cord-018182-lleti89n	285	23	postoperative	postoperative	JJ
cord-018182-lleti89n	285	24	outcome	outcome	NN
cord-018182-lleti89n	285	25	of	of	IN
cord-018182-lleti89n	285	26	non	non	JJ
cord-018182-lleti89n	285	27	-	-	JJ
cord-018182-lleti89n	285	28	cardiac	cardiac	JJ
cord-018182-lleti89n	285	29	surgery	surgery	NN
cord-018182-lleti89n	285	30	Perioperative	Perioperative	NNP
cord-018182-lleti89n	285	31	risk	risk	NN
cord-018182-lleti89n	285	32	and	and	CC
cord-018182-lleti89n	285	33	management	management	NN
cord-018182-lleti89n	285	34	of	of	IN
cord-018182-lleti89n	285	35	patients	patient	NNS
cord-018182-lleti89n	285	36	with	with	IN
cord-018182-lleti89n	285	37	pulmonary	pulmonary	JJ
cord-018182-lleti89n	285	38	hypertension	hypertension	NN