id sid tid token lemma pos cord-019043-cqmqwl3i 1 1 key key JJ cord-019043-cqmqwl3i 2 1 : : : cord-019043-cqmqwl3i 2 2 cord-019043-cqmqwl3i cord-019043-cqmqwl3i JJ cord-019043-cqmqwl3i 2 3 authors author NNS cord-019043-cqmqwl3i 2 4 : : : cord-019043-cqmqwl3i 2 5 Fidalgo Fidalgo NNP cord-019043-cqmqwl3i 2 6 , , , cord-019043-cqmqwl3i 2 7 Pedro Pedro NNP cord-019043-cqmqwl3i 2 8 ; ; : cord-019043-cqmqwl3i 2 9 Bagshaw Bagshaw NNP cord-019043-cqmqwl3i 2 10 , , , cord-019043-cqmqwl3i 2 11 Sean Sean NNP cord-019043-cqmqwl3i 2 12 M. M. NNP cord-019043-cqmqwl3i 2 13 title title NN cord-019043-cqmqwl3i 2 14 : : : cord-019043-cqmqwl3i 2 15 Chronic chronic JJ cord-019043-cqmqwl3i 2 16 Kidney kidney NN cord-019043-cqmqwl3i 2 17 Disease Disease NNP cord-019043-cqmqwl3i 2 18 in in IN cord-019043-cqmqwl3i 2 19 the the DT cord-019043-cqmqwl3i 2 20 Intensive Intensive NNP cord-019043-cqmqwl3i 2 21 Care Care NNP cord-019043-cqmqwl3i 2 22 Unit Unit NNP cord-019043-cqmqwl3i 2 23 date date NN cord-019043-cqmqwl3i 2 24 : : : cord-019043-cqmqwl3i 2 25 2014 2014 CD cord-019043-cqmqwl3i 2 26 - - HYPH cord-019043-cqmqwl3i 2 27 03 03 CD cord-019043-cqmqwl3i 2 28 - - HYPH cord-019043-cqmqwl3i 2 29 08 08 CD cord-019043-cqmqwl3i 2 30 journal journal NN cord-019043-cqmqwl3i 2 31 : : : cord-019043-cqmqwl3i 2 32 Management management NN cord-019043-cqmqwl3i 2 33 of of IN cord-019043-cqmqwl3i 2 34 Chronic Chronic NNP cord-019043-cqmqwl3i 2 35 Kidney Kidney NNP cord-019043-cqmqwl3i 2 36 Disease Disease NNP cord-019043-cqmqwl3i 2 37 DOI doi NN cord-019043-cqmqwl3i 2 38 : : : cord-019043-cqmqwl3i 3 1 10.1007/978 10.1007/978 LS cord-019043-cqmqwl3i 3 2 - - SYM cord-019043-cqmqwl3i 3 3 3 3 CD cord-019043-cqmqwl3i 3 4 - - HYPH cord-019043-cqmqwl3i 3 5 642 642 CD cord-019043-cqmqwl3i 3 6 - - HYPH cord-019043-cqmqwl3i 3 7 54637 54637 CD cord-019043-cqmqwl3i 3 8 - - HYPH cord-019043-cqmqwl3i 3 9 2_32 2_32 CD cord-019043-cqmqwl3i 3 10 sha sha NNP cord-019043-cqmqwl3i 3 11 : : : cord-019043-cqmqwl3i 4 1 7de5ab169387161a4b90c49826e7aad9f28f641c 7de5ab169387161a4b90c49826e7aad9f28f641c NNP cord-019043-cqmqwl3i 4 2 doc_id doc_id CD cord-019043-cqmqwl3i 4 3 : : : cord-019043-cqmqwl3i 5 1 19043 19043 CD cord-019043-cqmqwl3i 5 2 cord_uid cord_uid NNS cord-019043-cqmqwl3i 5 3 : : : cord-019043-cqmqwl3i 6 1 cqmqwl3i cqmqwl3i NNP cord-019043-cqmqwl3i 7 1 The the DT cord-019043-cqmqwl3i 7 2 incidence incidence NN cord-019043-cqmqwl3i 7 3 and and CC cord-019043-cqmqwl3i 7 4 prevalence prevalence NN cord-019043-cqmqwl3i 7 5 of of IN cord-019043-cqmqwl3i 7 6 chronic chronic JJ cord-019043-cqmqwl3i 7 7 kidney kidney NN cord-019043-cqmqwl3i 7 8 disease disease NN cord-019043-cqmqwl3i 7 9 ( ( -LRB- cord-019043-cqmqwl3i 7 10 CKD CKD NNP cord-019043-cqmqwl3i 7 11 ) ) -RRB- cord-019043-cqmqwl3i 7 12 and and CC cord-019043-cqmqwl3i 7 13 end end NN cord-019043-cqmqwl3i 7 14 - - HYPH cord-019043-cqmqwl3i 7 15 stage stage NN cord-019043-cqmqwl3i 7 16 renal renal JJ cord-019043-cqmqwl3i 7 17 disease disease NN cord-019043-cqmqwl3i 7 18 are be VBP cord-019043-cqmqwl3i 7 19 increasing increase VBG cord-019043-cqmqwl3i 7 20 , , , cord-019043-cqmqwl3i 7 21 and and CC cord-019043-cqmqwl3i 7 22 these these DT cord-019043-cqmqwl3i 7 23 patients patient NNS cord-019043-cqmqwl3i 7 24 have have VBP cord-019043-cqmqwl3i 7 25 a a DT cord-019043-cqmqwl3i 7 26 higher high JJR cord-019043-cqmqwl3i 7 27 risk risk NN cord-019043-cqmqwl3i 7 28 of of IN cord-019043-cqmqwl3i 7 29 developing develop VBG cord-019043-cqmqwl3i 7 30 critical critical JJ cord-019043-cqmqwl3i 7 31 illness illness NN cord-019043-cqmqwl3i 7 32 and and CC cord-019043-cqmqwl3i 7 33 being be VBG cord-019043-cqmqwl3i 7 34 admitted admit VBN cord-019043-cqmqwl3i 7 35 to to IN cord-019043-cqmqwl3i 7 36 the the DT cord-019043-cqmqwl3i 7 37 intensive intensive JJ cord-019043-cqmqwl3i 7 38 care care NN cord-019043-cqmqwl3i 7 39 unit unit NN cord-019043-cqmqwl3i 7 40 ( ( -LRB- cord-019043-cqmqwl3i 7 41 ICU ICU NNP cord-019043-cqmqwl3i 7 42 ) ) -RRB- cord-019043-cqmqwl3i 7 43 compared compare VBN cord-019043-cqmqwl3i 7 44 to to IN cord-019043-cqmqwl3i 7 45 the the DT cord-019043-cqmqwl3i 7 46 general general JJ cord-019043-cqmqwl3i 7 47 population population NN cord-019043-cqmqwl3i 7 48 . . . cord-019043-cqmqwl3i 8 1 The the DT cord-019043-cqmqwl3i 8 2 higher high JJR cord-019043-cqmqwl3i 8 3 prevalence prevalence NN cord-019043-cqmqwl3i 8 4 of of IN cord-019043-cqmqwl3i 8 5 comorbid comorbid NN cord-019043-cqmqwl3i 8 6 disease disease NN cord-019043-cqmqwl3i 8 7 puts put VBZ cord-019043-cqmqwl3i 8 8 this this DT cord-019043-cqmqwl3i 8 9 population population NN cord-019043-cqmqwl3i 8 10 at at IN cord-019043-cqmqwl3i 8 11 higher high JJR cord-019043-cqmqwl3i 8 12 risk risk NN cord-019043-cqmqwl3i 8 13 for for IN cord-019043-cqmqwl3i 8 14 worse bad JJR cord-019043-cqmqwl3i 8 15 short- short- NNS cord-019043-cqmqwl3i 8 16 and and CC cord-019043-cqmqwl3i 8 17 long long JJ cord-019043-cqmqwl3i 8 18 - - HYPH cord-019043-cqmqwl3i 8 19 term term NN cord-019043-cqmqwl3i 8 20 outcomes outcome NNS cord-019043-cqmqwl3i 8 21 following follow VBG cord-019043-cqmqwl3i 8 22 ICU ICU NNP cord-019043-cqmqwl3i 8 23 admission admission NN cord-019043-cqmqwl3i 8 24 compared compare VBN cord-019043-cqmqwl3i 8 25 to to IN cord-019043-cqmqwl3i 8 26 the the DT cord-019043-cqmqwl3i 8 27 general general JJ cord-019043-cqmqwl3i 8 28 population population NN cord-019043-cqmqwl3i 8 29 , , , cord-019043-cqmqwl3i 8 30 although although IN cord-019043-cqmqwl3i 8 31 short short JJ cord-019043-cqmqwl3i 8 32 - - HYPH cord-019043-cqmqwl3i 8 33 term term NN cord-019043-cqmqwl3i 8 34 mortality mortality NN cord-019043-cqmqwl3i 8 35 seems seem VBZ cord-019043-cqmqwl3i 8 36 to to TO cord-019043-cqmqwl3i 8 37 be be VB cord-019043-cqmqwl3i 8 38 determined determine VBN cord-019043-cqmqwl3i 8 39 largely largely RB cord-019043-cqmqwl3i 8 40 by by IN cord-019043-cqmqwl3i 8 41 the the DT cord-019043-cqmqwl3i 8 42 acute acute JJ cord-019043-cqmqwl3i 8 43 illness illness NN cord-019043-cqmqwl3i 8 44 severity severity NN cord-019043-cqmqwl3i 8 45 rather rather RB cord-019043-cqmqwl3i 8 46 than than IN cord-019043-cqmqwl3i 8 47 CKD CKD NNP cord-019043-cqmqwl3i 8 48 status status NN cord-019043-cqmqwl3i 8 49 per per FW cord-019043-cqmqwl3i 8 50 se se FW cord-019043-cqmqwl3i 8 51 . . . cord-019043-cqmqwl3i 9 1 The the DT cord-019043-cqmqwl3i 9 2 pathophysiologic pathophysiologic NN cord-019043-cqmqwl3i 9 3 changes change VBZ cord-019043-cqmqwl3i 9 4 accompanying accompany VBG cord-019043-cqmqwl3i 9 5 CKD CKD NNP cord-019043-cqmqwl3i 9 6 present present JJ cord-019043-cqmqwl3i 9 7 unique unique JJ cord-019043-cqmqwl3i 9 8 challenges challenge NNS cord-019043-cqmqwl3i 9 9 to to IN cord-019043-cqmqwl3i 9 10 the the DT cord-019043-cqmqwl3i 9 11 management management NN cord-019043-cqmqwl3i 9 12 of of IN cord-019043-cqmqwl3i 9 13 acute acute JJ cord-019043-cqmqwl3i 9 14 critical critical JJ cord-019043-cqmqwl3i 9 15 illness illness NN cord-019043-cqmqwl3i 9 16 most most RBS cord-019043-cqmqwl3i 9 17 notably notably RB cord-019043-cqmqwl3i 9 18 volume volume VBP cord-019043-cqmqwl3i 9 19 and and CC cord-019043-cqmqwl3i 9 20 metabolic metabolic JJ cord-019043-cqmqwl3i 9 21 homeostasis homeostasis NN cord-019043-cqmqwl3i 9 22 and and CC cord-019043-cqmqwl3i 9 23 drug drug NN cord-019043-cqmqwl3i 9 24 dosing dosing NN cord-019043-cqmqwl3i 9 25 adjustment adjustment NN cord-019043-cqmqwl3i 9 26 . . . cord-019043-cqmqwl3i 10 1 CKD CKD NNP cord-019043-cqmqwl3i 10 2 is be VBZ cord-019043-cqmqwl3i 10 3 an an DT cord-019043-cqmqwl3i 10 4 important important JJ cord-019043-cqmqwl3i 10 5 risk risk NN cord-019043-cqmqwl3i 10 6 factor factor NN cord-019043-cqmqwl3i 10 7 for for IN cord-019043-cqmqwl3i 10 8 the the DT cord-019043-cqmqwl3i 10 9 development development NN cord-019043-cqmqwl3i 10 10 of of IN cord-019043-cqmqwl3i 10 11 acute acute JJ cord-019043-cqmqwl3i 10 12 kidney kidney NN cord-019043-cqmqwl3i 10 13 injury injury NN cord-019043-cqmqwl3i 10 14 ( ( -LRB- cord-019043-cqmqwl3i 10 15 AKI AKI NNP cord-019043-cqmqwl3i 10 16 ) ) -RRB- cord-019043-cqmqwl3i 10 17 complicating complicate VBG cord-019043-cqmqwl3i 10 18 critical critical JJ cord-019043-cqmqwl3i 10 19 illness illness NN cord-019043-cqmqwl3i 10 20 and and CC cord-019043-cqmqwl3i 10 21 can can MD cord-019043-cqmqwl3i 10 22 predispose predispose VB cord-019043-cqmqwl3i 10 23 to to TO cord-019043-cqmqwl3i 10 24 further further RB cord-019043-cqmqwl3i 10 25 accelerated accelerate VBN cord-019043-cqmqwl3i 10 26 decline decline NN cord-019043-cqmqwl3i 10 27 in in IN cord-019043-cqmqwl3i 10 28 kidney kidney NN cord-019043-cqmqwl3i 10 29 function function NN cord-019043-cqmqwl3i 10 30 among among IN cord-019043-cqmqwl3i 10 31 ICU ICU NNP cord-019043-cqmqwl3i 10 32 survivors survivor NNS cord-019043-cqmqwl3i 10 33 . . . cord-019043-cqmqwl3i 11 1 Renal renal JJ cord-019043-cqmqwl3i 11 2 replacement replacement NN cord-019043-cqmqwl3i 11 3 therapy therapy NN cord-019043-cqmqwl3i 11 4 ( ( -LRB- cord-019043-cqmqwl3i 11 5 RRT rrt NN cord-019043-cqmqwl3i 11 6 ) ) -RRB- cord-019043-cqmqwl3i 11 7 support support NN cord-019043-cqmqwl3i 11 8 is be VBZ cord-019043-cqmqwl3i 11 9 frequently frequently RB cord-019043-cqmqwl3i 11 10 used use VBN cord-019043-cqmqwl3i 11 11 in in IN cord-019043-cqmqwl3i 11 12 ICU ICU NNP cord-019043-cqmqwl3i 11 13 settings setting NNS cord-019043-cqmqwl3i 11 14 , , , cord-019043-cqmqwl3i 11 15 and and CC cord-019043-cqmqwl3i 11 16 continuous continuous JJ cord-019043-cqmqwl3i 11 17 renal renal JJ cord-019043-cqmqwl3i 11 18 replacement replacement NN cord-019043-cqmqwl3i 11 19 therapy therapy NN cord-019043-cqmqwl3i 11 20 modality modality NN cord-019043-cqmqwl3i 11 21 remains remain VBZ cord-019043-cqmqwl3i 11 22 the the DT cord-019043-cqmqwl3i 11 23 most most RBS cord-019043-cqmqwl3i 11 24 commonly commonly RB cord-019043-cqmqwl3i 11 25 used use VBN cord-019043-cqmqwl3i 11 26 among among IN cord-019043-cqmqwl3i 11 27 critically critically RB cord-019043-cqmqwl3i 11 28 ill ill JJ cord-019043-cqmqwl3i 11 29 patients patient NNS cord-019043-cqmqwl3i 11 30 . . . cord-019043-cqmqwl3i 12 1 • • NNP cord-019043-cqmqwl3i 13 1 CKD CKD NNP cord-019043-cqmqwl3i 13 2 patients patient NNS cord-019043-cqmqwl3i 13 3 have have VBP cord-019043-cqmqwl3i 13 4 a a DT cord-019043-cqmqwl3i 13 5 high high JJ cord-019043-cqmqwl3i 13 6 prevalence prevalence NN cord-019043-cqmqwl3i 13 7 of of IN cord-019043-cqmqwl3i 13 8 comorbid comorbid NN cord-019043-cqmqwl3i 13 9 disease disease NN cord-019043-cqmqwl3i 13 10 compared compare VBN cord-019043-cqmqwl3i 13 11 to to IN cord-019043-cqmqwl3i 13 12 non non JJ cord-019043-cqmqwl3i 13 13 - - JJ cord-019043-cqmqwl3i 13 14 CKD ckd JJ cord-019043-cqmqwl3i 13 15 patients patient NNS cord-019043-cqmqwl3i 13 16 ; ; : cord-019043-cqmqwl3i 13 17 however however RB cord-019043-cqmqwl3i 13 18 , , , cord-019043-cqmqwl3i 13 19 CKD CKD NNP cord-019043-cqmqwl3i 13 20 patients patient NNS cord-019043-cqmqwl3i 13 21 have have VBP cord-019043-cqmqwl3i 13 22 reasonable reasonable JJ cord-019043-cqmqwl3i 13 23 short short JJ cord-019043-cqmqwl3i 13 24 - - HYPH cord-019043-cqmqwl3i 13 25 term term NN cord-019043-cqmqwl3i 13 26 outcomes outcome NNS cord-019043-cqmqwl3i 13 27 following follow VBG cord-019043-cqmqwl3i 13 28 ICU ICU NNP cord-019043-cqmqwl3i 13 29 admission admission NN cord-019043-cqmqwl3i 13 30 compared compare VBN cord-019043-cqmqwl3i 13 31 to to IN cord-019043-cqmqwl3i 13 32 non non JJ cord-019043-cqmqwl3i 13 33 - - JJ cord-019043-cqmqwl3i 13 34 CKD ckd JJ cord-019043-cqmqwl3i 13 35 patients patient NNS cord-019043-cqmqwl3i 13 36 . . . cord-019043-cqmqwl3i 14 1 • • NNP cord-019043-cqmqwl3i 15 1 The the DT cord-019043-cqmqwl3i 15 2 most most RBS cord-019043-cqmqwl3i 15 3 common common JJ cord-019043-cqmqwl3i 15 4 diagnoses diagnosis NNS cord-019043-cqmqwl3i 15 5 contributing contribute VBG cord-019043-cqmqwl3i 15 6 to to IN cord-019043-cqmqwl3i 15 7 ICU ICU NNP cord-019043-cqmqwl3i 15 8 admission admission NN cord-019043-cqmqwl3i 15 9 in in IN cord-019043-cqmqwl3i 15 10 CKD CKD NNP cord-019043-cqmqwl3i 15 11 patients patient NNS cord-019043-cqmqwl3i 15 12 are be VBP cord-019043-cqmqwl3i 15 13 sepsis sepsis NN cord-019043-cqmqwl3i 15 14 and and CC cord-019043-cqmqwl3i 15 15 septic septic JJ cord-019043-cqmqwl3i 15 16 shock shock NN cord-019043-cqmqwl3i 15 17 and and CC cord-019043-cqmqwl3i 15 18 decompensated decompensate VBD cord-019043-cqmqwl3i 15 19 cardiovascular cardiovascular JJ cord-019043-cqmqwl3i 15 20 disease disease NN cord-019043-cqmqwl3i 15 21 . . . cord-019043-cqmqwl3i 16 1 • • NNP cord-019043-cqmqwl3i 17 1 AKI AKI NNP cord-019043-cqmqwl3i 17 2 is be VBZ cord-019043-cqmqwl3i 17 3 a a DT cord-019043-cqmqwl3i 17 4 common common JJ cord-019043-cqmqwl3i 17 5 complication complication NN cord-019043-cqmqwl3i 17 6 of of IN cord-019043-cqmqwl3i 17 7 critical critical JJ cord-019043-cqmqwl3i 17 8 illness illness NN cord-019043-cqmqwl3i 17 9 , , , cord-019043-cqmqwl3i 17 10 most most RBS cord-019043-cqmqwl3i 17 11 often often RB cord-019043-cqmqwl3i 17 12 precipitated precipitate VBN cord-019043-cqmqwl3i 17 13 by by IN cord-019043-cqmqwl3i 17 14 sepsis sepsis NN cord-019043-cqmqwl3i 17 15 , , , cord-019043-cqmqwl3i 17 16 and and CC cord-019043-cqmqwl3i 17 17 remains remain VBZ cord-019043-cqmqwl3i 17 18 a a DT cord-019043-cqmqwl3i 17 19 strong strong JJ cord-019043-cqmqwl3i 17 20 negative negative JJ cord-019043-cqmqwl3i 17 21 modifier modifier NN cord-019043-cqmqwl3i 17 22 of of IN cord-019043-cqmqwl3i 17 23 short short JJ cord-019043-cqmqwl3i 17 24 - - HYPH cord-019043-cqmqwl3i 17 25 and and CC cord-019043-cqmqwl3i 17 26 long long JJ cord-019043-cqmqwl3i 17 27 - - HYPH cord-019043-cqmqwl3i 17 28 term term NN cord-019043-cqmqwl3i 17 29 survival survival NN cord-019043-cqmqwl3i 17 30 . . . cord-019043-cqmqwl3i 18 1 • • NNP cord-019043-cqmqwl3i 19 1 CKD CKD NNP cord-019043-cqmqwl3i 19 2 is be VBZ cord-019043-cqmqwl3i 19 3 an an DT cord-019043-cqmqwl3i 19 4 important important JJ cord-019043-cqmqwl3i 19 5 and and CC cord-019043-cqmqwl3i 19 6 independent independent JJ cord-019043-cqmqwl3i 19 7 nonmodifiable nonmodifiable JJ cord-019043-cqmqwl3i 19 8 risk risk NN cord-019043-cqmqwl3i 19 9 factor factor NN cord-019043-cqmqwl3i 19 10 for for IN cord-019043-cqmqwl3i 19 11 development development NN cord-019043-cqmqwl3i 19 12 of of IN cord-019043-cqmqwl3i 19 13 AKI AKI NNP cord-019043-cqmqwl3i 19 14 and and CC cord-019043-cqmqwl3i 19 15 long long JJ cord-019043-cqmqwl3i 19 16 - - HYPH cord-019043-cqmqwl3i 19 17 term term NN cord-019043-cqmqwl3i 19 18 accelerated accelerate VBN cord-019043-cqmqwl3i 19 19 loss loss NN cord-019043-cqmqwl3i 19 20 of of IN cord-019043-cqmqwl3i 19 21 kidney kidney NN cord-019043-cqmqwl3i 19 22 function function NN cord-019043-cqmqwl3i 19 23 among among IN cord-019043-cqmqwl3i 19 24 CKD CKD NNP cord-019043-cqmqwl3i 19 25 survivor survivor NN cord-019043-cqmqwl3i 19 26 of of IN cord-019043-cqmqwl3i 19 27 critical critical JJ cord-019043-cqmqwl3i 19 28 illness illness NN cord-019043-cqmqwl3i 19 29 . . . cord-019043-cqmqwl3i 20 1 • • XX cord-019043-cqmqwl3i 20 2 While while IN cord-019043-cqmqwl3i 20 3 numerous numerous JJ cord-019043-cqmqwl3i 20 4 factors factor NNS cord-019043-cqmqwl3i 20 5 influence influence VBP cord-019043-cqmqwl3i 20 6 the the DT cord-019043-cqmqwl3i 20 7 decision decision NN cord-019043-cqmqwl3i 20 8 to to TO cord-019043-cqmqwl3i 20 9 start start VB cord-019043-cqmqwl3i 20 10 renal renal JJ cord-019043-cqmqwl3i 20 11 replacement replacement NN cord-019043-cqmqwl3i 20 12 therapy therapy NN cord-019043-cqmqwl3i 20 13 , , , cord-019043-cqmqwl3i 20 14 the the DT cord-019043-cqmqwl3i 20 15 most most RBS cord-019043-cqmqwl3i 20 16 common common JJ cord-019043-cqmqwl3i 20 17 initial initial JJ cord-019043-cqmqwl3i 20 18 modality modality NN cord-019043-cqmqwl3i 20 19 prescribed prescribe VBN cord-019043-cqmqwl3i 20 20 after after IN cord-019043-cqmqwl3i 20 21 ICU ICU NNP cord-019043-cqmqwl3i 20 22 admission admission NN cord-019043-cqmqwl3i 20 23 worldwide worldwide RB cord-019043-cqmqwl3i 20 24 remains remain VBZ cord-019043-cqmqwl3i 20 25 continuous continuous JJ cord-019043-cqmqwl3i 20 26 renal renal JJ cord-019043-cqmqwl3i 20 27 replacement replacement NN cord-019043-cqmqwl3i 20 28 therapy therapy NN cord-019043-cqmqwl3i 20 29 , , , cord-019043-cqmqwl3i 20 30 particularly particularly RB cord-019043-cqmqwl3i 20 31 for for IN cord-019043-cqmqwl3i 20 32 hemodynamically hemodynamically RB cord-019043-cqmqwl3i 20 33 unstable unstable JJ cord-019043-cqmqwl3i 20 34 patients patient NNS cord-019043-cqmqwl3i 20 35 , , , cord-019043-cqmqwl3i 20 36 and and CC cord-019043-cqmqwl3i 20 37 this this DT cord-019043-cqmqwl3i 20 38 may may MD cord-019043-cqmqwl3i 20 39 be be VB cord-019043-cqmqwl3i 20 40 associated associate VBN cord-019043-cqmqwl3i 20 41 with with IN cord-019043-cqmqwl3i 20 42 higher high JJR cord-019043-cqmqwl3i 20 43 likelihood likelihood NN cord-019043-cqmqwl3i 20 44 of of IN cord-019043-cqmqwl3i 20 45 recovery recovery NN cord-019043-cqmqwl3i 20 46 of of IN cord-019043-cqmqwl3i 20 47 renal renal JJ cord-019043-cqmqwl3i 20 48 function function NN cord-019043-cqmqwl3i 20 49 and and CC cord-019043-cqmqwl3i 20 50 dialysis dialysis NN cord-019043-cqmqwl3i 20 51 independence independence NN cord-019043-cqmqwl3i 20 52 . . . cord-019043-cqmqwl3i 21 1 ESRD ESRD NNP cord-019043-cqmqwl3i 21 2 , , , cord-019043-cqmqwl3i 21 3 have have VBP cord-019043-cqmqwl3i 21 4 a a DT cord-019043-cqmqwl3i 21 5 several several JJ cord-019043-cqmqwl3i 21 6 - - HYPH cord-019043-cqmqwl3i 21 7 fold fold VB cord-019043-cqmqwl3i 21 8 higher high JJR cord-019043-cqmqwl3i 21 9 risk risk NN cord-019043-cqmqwl3i 21 10 of of IN cord-019043-cqmqwl3i 21 11 developing develop VBG cord-019043-cqmqwl3i 21 12 critical critical JJ cord-019043-cqmqwl3i 21 13 illness illness NN cord-019043-cqmqwl3i 21 14 . . . cord-019043-cqmqwl3i 22 1 When when WRB cord-019043-cqmqwl3i 22 2 considering consider VBG cord-019043-cqmqwl3i 22 3 these these DT cord-019043-cqmqwl3i 22 4 features feature NNS cord-019043-cqmqwl3i 22 5 , , , cord-019043-cqmqwl3i 22 6 coupled couple VBN cord-019043-cqmqwl3i 22 7 with with IN cord-019043-cqmqwl3i 22 8 rising rise VBG cord-019043-cqmqwl3i 22 9 prevalence prevalence NN cord-019043-cqmqwl3i 22 10 rates rate NNS cord-019043-cqmqwl3i 22 11 , , , cord-019043-cqmqwl3i 22 12 the the DT cord-019043-cqmqwl3i 22 13 demand demand NN cord-019043-cqmqwl3i 22 14 for for IN cord-019043-cqmqwl3i 22 15 intensive intensive JJ cord-019043-cqmqwl3i 22 16 care care NN cord-019043-cqmqwl3i 22 17 unit unit NN cord-019043-cqmqwl3i 22 18 ( ( -LRB- cord-019043-cqmqwl3i 22 19 ICU ICU NNP cord-019043-cqmqwl3i 22 20 ) ) -RRB- cord-019043-cqmqwl3i 22 21 support support NN cord-019043-cqmqwl3i 22 22 for for IN cord-019043-cqmqwl3i 22 23 CKD CKD NNP cord-019043-cqmqwl3i 22 24 patients patient NNS cord-019043-cqmqwl3i 22 25 is be VBZ cord-019043-cqmqwl3i 22 26 expected expect VBN cord-019043-cqmqwl3i 22 27 to to TO cord-019043-cqmqwl3i 22 28 increase increase VB cord-019043-cqmqwl3i 22 29 . . . cord-019043-cqmqwl3i 23 1 This this DT cord-019043-cqmqwl3i 23 2 will will MD cord-019043-cqmqwl3i 23 3 likely likely RB cord-019043-cqmqwl3i 23 4 present present VB cord-019043-cqmqwl3i 23 5 challenges challenge NNS cord-019043-cqmqwl3i 23 6 for for IN cord-019043-cqmqwl3i 23 7 clinicians clinician NNS cord-019043-cqmqwl3i 23 8 working work VBG cord-019043-cqmqwl3i 23 9 in in IN cord-019043-cqmqwl3i 23 10 resource resource NN cord-019043-cqmqwl3i 23 11 - - HYPH cord-019043-cqmqwl3i 23 12 limited limit VBN cord-019043-cqmqwl3i 23 13 settings setting NNS cord-019043-cqmqwl3i 23 14 regarding regard VBG cord-019043-cqmqwl3i 23 15 decisionmaking decisionmaking NN cord-019043-cqmqwl3i 23 16 for for IN cord-019043-cqmqwl3i 23 17 ICU ICU NNP cord-019043-cqmqwl3i 23 18 support support NN cord-019043-cqmqwl3i 23 19 for for IN cord-019043-cqmqwl3i 23 20 CKD CKD NNP cord-019043-cqmqwl3i 23 21 patients patient NNS cord-019043-cqmqwl3i 23 22 . . . cord-019043-cqmqwl3i 24 1 There there EX cord-019043-cqmqwl3i 24 2 is be VBZ cord-019043-cqmqwl3i 24 3 limited limited JJ cord-019043-cqmqwl3i 24 4 data datum NNS cord-019043-cqmqwl3i 24 5 available available JJ cord-019043-cqmqwl3i 24 6 on on IN cord-019043-cqmqwl3i 24 7 the the DT cord-019043-cqmqwl3i 24 8 prevalence prevalence NN cord-019043-cqmqwl3i 24 9 of of IN cord-019043-cqmqwl3i 24 10 CKD CKD NNP cord-019043-cqmqwl3i 24 11 among among IN cord-019043-cqmqwl3i 24 12 all all DT cord-019043-cqmqwl3i 24 13 critically critically RB cord-019043-cqmqwl3i 24 14 ill ill JJ cord-019043-cqmqwl3i 24 15 patients patient NNS cord-019043-cqmqwl3i 24 16 supported support VBN cord-019043-cqmqwl3i 24 17 in in IN cord-019043-cqmqwl3i 24 18 ICU ICU NNP cord-019043-cqmqwl3i 24 19 settings setting NNS cord-019043-cqmqwl3i 24 20 , , , cord-019043-cqmqwl3i 24 21 and and CC cord-019043-cqmqwl3i 24 22 most most JJS cord-019043-cqmqwl3i 24 23 studies study NNS cord-019043-cqmqwl3i 24 24 have have VBP cord-019043-cqmqwl3i 24 25 focused focus VBN cord-019043-cqmqwl3i 24 26 on on IN cord-019043-cqmqwl3i 24 27 the the DT cord-019043-cqmqwl3i 24 28 subset subset NN cord-019043-cqmqwl3i 24 29 of of IN cord-019043-cqmqwl3i 24 30 dialysis dialysis NN cord-019043-cqmqwl3i 24 31 - - HYPH cord-019043-cqmqwl3i 24 32 dependent dependent JJ cord-019043-cqmqwl3i 24 33 patients patient NNS cord-019043-cqmqwl3i 24 34 with with IN cord-019043-cqmqwl3i 24 35 ESRD ESRD NNP cord-019043-cqmqwl3i 24 36 [ [ -LRB- cord-019043-cqmqwl3i 24 37 1 1 CD cord-019043-cqmqwl3i 24 38 ] ] -RRB- cord-019043-cqmqwl3i 24 39 . . . cord-019043-cqmqwl3i 25 1 Available available JJ cord-019043-cqmqwl3i 25 2 data datum NNS cord-019043-cqmqwl3i 25 3 would would MD cord-019043-cqmqwl3i 25 4 suggest suggest VB cord-019043-cqmqwl3i 25 5 the the DT cord-019043-cqmqwl3i 25 6 proportion proportion NN cord-019043-cqmqwl3i 25 7 of of IN cord-019043-cqmqwl3i 25 8 patients patient NNS cord-019043-cqmqwl3i 25 9 admitted admit VBN cord-019043-cqmqwl3i 25 10 to to IN cord-019043-cqmqwl3i 25 11 ICU ICU NNP cord-019043-cqmqwl3i 25 12 with with IN cord-019043-cqmqwl3i 25 13 ESRD ESRD NNP cord-019043-cqmqwl3i 25 14 ranges range VBZ cord-019043-cqmqwl3i 25 15 between between IN cord-019043-cqmqwl3i 25 16 1 1 CD cord-019043-cqmqwl3i 25 17 and and CC cord-019043-cqmqwl3i 25 18 9 9 CD cord-019043-cqmqwl3i 25 19 % % NN cord-019043-cqmqwl3i 25 20 . . . cord-019043-cqmqwl3i 26 1 The the DT cord-019043-cqmqwl3i 26 2 reported reported JJ cord-019043-cqmqwl3i 26 3 variability variability NN cord-019043-cqmqwl3i 26 4 in in IN cord-019043-cqmqwl3i 26 5 ESRD ESRD NNP cord-019043-cqmqwl3i 26 6 admissions admission NNS cord-019043-cqmqwl3i 26 7 across across IN cord-019043-cqmqwl3i 26 8 studies study NNS cord-019043-cqmqwl3i 26 9 is be VBZ cord-019043-cqmqwl3i 26 10 likely likely RB cord-019043-cqmqwl3i 26 11 accounted account VBN cord-019043-cqmqwl3i 26 12 for for IN cord-019043-cqmqwl3i 26 13 by by IN cord-019043-cqmqwl3i 26 14 differences difference NNS cord-019043-cqmqwl3i 26 15 in in IN cord-019043-cqmqwl3i 26 16 practice practice NN cord-019043-cqmqwl3i 26 17 patterns pattern NNS cord-019043-cqmqwl3i 26 18 , , , cord-019043-cqmqwl3i 26 19 availability availability NN cord-019043-cqmqwl3i 26 20 of of IN cord-019043-cqmqwl3i 26 21 ICU ICU NNP cord-019043-cqmqwl3i 26 22 resources resource NNS cord-019043-cqmqwl3i 26 23 , , , cord-019043-cqmqwl3i 26 24 patient patient JJ cord-019043-cqmqwl3i 26 25 case case NN cord-019043-cqmqwl3i 26 26 - - HYPH cord-019043-cqmqwl3i 26 27 mix mix NN cord-019043-cqmqwl3i 26 28 , , , cord-019043-cqmqwl3i 26 29 and and CC cord-019043-cqmqwl3i 26 30 study study NN cord-019043-cqmqwl3i 26 31 design design NN cord-019043-cqmqwl3i 26 32 . . . cord-019043-cqmqwl3i 27 1 ESRD ESRD NNP cord-019043-cqmqwl3i 27 2 patients patient NNS cord-019043-cqmqwl3i 27 3 have have VBP cord-019043-cqmqwl3i 27 4 consistently consistently RB cord-019043-cqmqwl3i 27 5 been be VBN cord-019043-cqmqwl3i 27 6 shown show VBN cord-019043-cqmqwl3i 27 7 to to TO cord-019043-cqmqwl3i 27 8 have have VB cord-019043-cqmqwl3i 27 9 an an DT cord-019043-cqmqwl3i 27 10 estimated estimate VBN cord-019043-cqmqwl3i 27 11 25 25 CD cord-019043-cqmqwl3i 27 12 - - HYPH cord-019043-cqmqwl3i 27 13 30fold 30fold CD cord-019043-cqmqwl3i 27 14 higher high JJR cord-019043-cqmqwl3i 27 15 annual annual JJ cord-019043-cqmqwl3i 27 16 likelihood likelihood NN cord-019043-cqmqwl3i 27 17 of of IN cord-019043-cqmqwl3i 27 18 admission admission NN cord-019043-cqmqwl3i 27 19 to to IN cord-019043-cqmqwl3i 27 20 ICU ICU NNP cord-019043-cqmqwl3i 27 21 when when WRB cord-019043-cqmqwl3i 27 22 compared compare VBN cord-019043-cqmqwl3i 27 23 with with IN cord-019043-cqmqwl3i 27 24 the the DT cord-019043-cqmqwl3i 27 25 non non JJ cord-019043-cqmqwl3i 27 26 - - JJ cord-019043-cqmqwl3i 27 27 ESRD esrd JJ cord-019043-cqmqwl3i 27 28 general general JJ cord-019043-cqmqwl3i 27 29 population population NN cord-019043-cqmqwl3i 27 30 . . . cord-019043-cqmqwl3i 28 1 ESRD ESRD NNP cord-019043-cqmqwl3i 28 2 patients patient NNS cord-019043-cqmqwl3i 28 3 admitted admit VBD cord-019043-cqmqwl3i 28 4 to to IN cord-019043-cqmqwl3i 28 5 ICU ICU NNP cord-019043-cqmqwl3i 28 6 have have VBP cord-019043-cqmqwl3i 28 7 several several JJ cord-019043-cqmqwl3i 28 8 notable notable JJ cord-019043-cqmqwl3i 28 9 differences difference NNS cord-019043-cqmqwl3i 28 10 in in IN cord-019043-cqmqwl3i 28 11 baseline baseline JJ cord-019043-cqmqwl3i 28 12 characteristics characteristic NNS cord-019043-cqmqwl3i 28 13 when when WRB cord-019043-cqmqwl3i 28 14 compared compare VBN cord-019043-cqmqwl3i 28 15 with with IN cord-019043-cqmqwl3i 28 16 non non JJ cord-019043-cqmqwl3i 28 17 - - JJ cord-019043-cqmqwl3i 28 18 ESRD esrd JJ cord-019043-cqmqwl3i 28 19 patients patient NNS cord-019043-cqmqwl3i 28 20 . . . cord-019043-cqmqwl3i 29 1 ESRD ESRD NNP cord-019043-cqmqwl3i 29 2 patients patient NNS cord-019043-cqmqwl3i 29 3 are be VBP cord-019043-cqmqwl3i 29 4 generally generally RB cord-019043-cqmqwl3i 29 5 younger young JJR cord-019043-cqmqwl3i 29 6 , , , cord-019043-cqmqwl3i 29 7 have have VBP cord-019043-cqmqwl3i 29 8 more more RBR cord-019043-cqmqwl3i 29 9 comorbid comorbid JJ cord-019043-cqmqwl3i 29 10 disease disease NN cord-019043-cqmqwl3i 29 11 , , , cord-019043-cqmqwl3i 29 12 more more RBR cord-019043-cqmqwl3i 29 13 likely likely JJ cord-019043-cqmqwl3i 29 14 medical medical JJ cord-019043-cqmqwl3i 29 15 ( ( -LRB- cord-019043-cqmqwl3i 29 16 i.e. i.e. FW cord-019043-cqmqwl3i 29 17 , , , cord-019043-cqmqwl3i 29 18 nonoperative nonoperative JJ cord-019043-cqmqwl3i 29 19 admissions admission NNS cord-019043-cqmqwl3i 29 20 ) ) -RRB- cord-019043-cqmqwl3i 29 21 , , , cord-019043-cqmqwl3i 29 22 and and CC cord-019043-cqmqwl3i 29 23 have have VBP cord-019043-cqmqwl3i 29 24 higher high JJR cord-019043-cqmqwl3i 29 25 illness illness NN cord-019043-cqmqwl3i 29 26 severity severity NN cord-019043-cqmqwl3i 29 27 scores score NNS cord-019043-cqmqwl3i 29 28 compared compare VBN cord-019043-cqmqwl3i 29 29 with with IN cord-019043-cqmqwl3i 29 30 non non JJ cord-019043-cqmqwl3i 29 31 - - JJ cord-019043-cqmqwl3i 29 32 ESRD esrd JJ cord-019043-cqmqwl3i 29 33 patients patient NNS cord-019043-cqmqwl3i 29 34 . . . cord-019043-cqmqwl3i 30 1 However however RB cord-019043-cqmqwl3i 30 2 , , , cord-019043-cqmqwl3i 30 3 these these DT cord-019043-cqmqwl3i 30 4 observations observation NNS cord-019043-cqmqwl3i 30 5 may may MD cord-019043-cqmqwl3i 30 6 be be VB cord-019043-cqmqwl3i 30 7 susceptible susceptible JJ cord-019043-cqmqwl3i 30 8 to to IN cord-019043-cqmqwl3i 30 9 selection selection NN cord-019043-cqmqwl3i 30 10 bias bias NN cord-019043-cqmqwl3i 30 11 . . . cord-019043-cqmqwl3i 31 1 Available available JJ cord-019043-cqmqwl3i 31 2 epidemiologic epidemiologic JJ cord-019043-cqmqwl3i 31 3 surveys survey NNS cord-019043-cqmqwl3i 31 4 of of IN cord-019043-cqmqwl3i 31 5 ESRD ESRD NNP cord-019043-cqmqwl3i 31 6 patients patient NNS cord-019043-cqmqwl3i 31 7 admitted admit VBN cord-019043-cqmqwl3i 31 8 to to IN cord-019043-cqmqwl3i 31 9 ICU ICU NNP cord-019043-cqmqwl3i 31 10 are be VBP cord-019043-cqmqwl3i 31 11 limited limit VBN cord-019043-cqmqwl3i 31 12 by by IN cord-019043-cqmqwl3i 31 13 not not RB cord-019043-cqmqwl3i 31 14 accounting account VBG cord-019043-cqmqwl3i 31 15 for for IN cord-019043-cqmqwl3i 31 16 those those DT cord-019043-cqmqwl3i 31 17 patients patient NNS cord-019043-cqmqwl3i 31 18 referred refer VBD cord-019043-cqmqwl3i 31 19 and and CC cord-019043-cqmqwl3i 31 20 refused refuse VBD cord-019043-cqmqwl3i 31 21 ICU ICU NNP cord-019043-cqmqwl3i 31 22 admission admission NN cord-019043-cqmqwl3i 31 23 . . . cord-019043-cqmqwl3i 32 1 The the DT cord-019043-cqmqwl3i 32 2 most most RBS cord-019043-cqmqwl3i 32 3 common common JJ cord-019043-cqmqwl3i 32 4 precipitants precipitant NNS cord-019043-cqmqwl3i 32 5 of of IN cord-019043-cqmqwl3i 32 6 critical critical JJ cord-019043-cqmqwl3i 32 7 illness illness NN cord-019043-cqmqwl3i 32 8 prompting prompt VBG cord-019043-cqmqwl3i 32 9 ICU ICU NNP cord-019043-cqmqwl3i 32 10 admission admission NN cord-019043-cqmqwl3i 32 11 among among IN cord-019043-cqmqwl3i 32 12 ESRD ESRD NNP cord-019043-cqmqwl3i 32 13 patients patient NNS cord-019043-cqmqwl3i 32 14 are be VBP cord-019043-cqmqwl3i 32 15 sepsis sepsis NN cord-019043-cqmqwl3i 32 16 / / SYM cord-019043-cqmqwl3i 32 17 septic septic JJ cord-019043-cqmqwl3i 32 18 shock shock NN cord-019043-cqmqwl3i 32 19 and and CC cord-019043-cqmqwl3i 32 20 decompensated decompensate VBD cord-019043-cqmqwl3i 32 21 cardiovascular cardiovascular JJ cord-019043-cqmqwl3i 32 22 disease disease NN cord-019043-cqmqwl3i 32 23 including include VBG cord-019043-cqmqwl3i 32 24 cardiogenic cardiogenic JJ cord-019043-cqmqwl3i 32 25 shock shock NN cord-019043-cqmqwl3i 32 26 , , , cord-019043-cqmqwl3i 32 27 myocardial myocardial JJ cord-019043-cqmqwl3i 32 28 ischemia ischemia NN cord-019043-cqmqwl3i 32 29 / / SYM cord-019043-cqmqwl3i 32 30 infarction infarction NN cord-019043-cqmqwl3i 32 31 , , , cord-019043-cqmqwl3i 32 32 arrhythmic arrhythmic JJ cord-019043-cqmqwl3i 32 33 complications complication NNS cord-019043-cqmqwl3i 32 34 , , , cord-019043-cqmqwl3i 32 35 and and CC cord-019043-cqmqwl3i 32 36 heart heart NN cord-019043-cqmqwl3i 32 37 failure failure NN cord-019043-cqmqwl3i 32 38 / / SYM cord-019043-cqmqwl3i 32 39 pulmonary pulmonary JJ cord-019043-cqmqwl3i 32 40 edema edema NN cord-019043-cqmqwl3i 32 41 . . . cord-019043-cqmqwl3i 33 1 Cardiac cardiac JJ cord-019043-cqmqwl3i 33 2 arrest arrest NN cord-019043-cqmqwl3i 33 3 and and CC cord-019043-cqmqwl3i 33 4 cardiopulmonary cardiopulmonary JJ cord-019043-cqmqwl3i 33 5 resuscitation resuscitation NN cord-019043-cqmqwl3i 33 6 ( ( -LRB- cord-019043-cqmqwl3i 33 7 CPR CPR NNP cord-019043-cqmqwl3i 33 8 ) ) -RRB- cord-019043-cqmqwl3i 33 9 are be VBP cord-019043-cqmqwl3i 33 10 more more RBR cord-019043-cqmqwl3i 33 11 common common JJ cord-019043-cqmqwl3i 33 12 events event NNS cord-019043-cqmqwl3i 33 13 occurring occur VBG cord-019043-cqmqwl3i 33 14 among among IN cord-019043-cqmqwl3i 33 15 ESRD ESRD NNP cord-019043-cqmqwl3i 33 16 patients patient NNS cord-019043-cqmqwl3i 33 17 compared compare VBN cord-019043-cqmqwl3i 33 18 with with IN cord-019043-cqmqwl3i 33 19 non non JJ cord-019043-cqmqwl3i 33 20 - - JJ cord-019043-cqmqwl3i 33 21 ESRD esrd JJ cord-019043-cqmqwl3i 33 22 prior prior RB cord-019043-cqmqwl3i 33 23 to to IN cord-019043-cqmqwl3i 33 24 ICU ICU NNP cord-019043-cqmqwl3i 33 25 admission admission NN cord-019043-cqmqwl3i 33 26 . . . cord-019043-cqmqwl3i 34 1 This this DT cord-019043-cqmqwl3i 34 2 may may MD cord-019043-cqmqwl3i 34 3 relate relate VB cord-019043-cqmqwl3i 34 4 to to IN cord-019043-cqmqwl3i 34 5 several several JJ cord-019043-cqmqwl3i 34 6 factors factor NNS cord-019043-cqmqwl3i 34 7 including include VBG cord-019043-cqmqwl3i 34 8 a a DT cord-019043-cqmqwl3i 34 9 higher high JJR cord-019043-cqmqwl3i 34 10 prevalence prevalence NN cord-019043-cqmqwl3i 34 11 of of IN cord-019043-cqmqwl3i 34 12 comorbid comorbid JJ cord-019043-cqmqwl3i 34 13 cardiovascular cardiovascular JJ cord-019043-cqmqwl3i 34 14 disease disease NN cord-019043-cqmqwl3i 34 15 and and CC cord-019043-cqmqwl3i 34 16 diminished diminish VBD cord-019043-cqmqwl3i 34 17 cardiopulmonary cardiopulmonary JJ cord-019043-cqmqwl3i 34 18 reserve reserve NN cord-019043-cqmqwl3i 34 19 , , , cord-019043-cqmqwl3i 34 20 a a DT cord-019043-cqmqwl3i 34 21 higher high JJR cord-019043-cqmqwl3i 34 22 incidence incidence NN cord-019043-cqmqwl3i 34 23 of of IN cord-019043-cqmqwl3i 34 24 primarily primarily RB cord-019043-cqmqwl3i 34 25 arrhythmic arrhythmic JJ cord-019043-cqmqwl3i 34 26 complications complication NNS cord-019043-cqmqwl3i 34 27 , , , cord-019043-cqmqwl3i 34 28 and and CC cord-019043-cqmqwl3i 34 29 the the DT cord-019043-cqmqwl3i 34 30 unique unique JJ cord-019043-cqmqwl3i 34 31 pathophysiologic pathophysiologic JJ cord-019043-cqmqwl3i 34 32 stress stress NN cord-019043-cqmqwl3i 34 33 of of IN cord-019043-cqmqwl3i 34 34 dialysis dialysis NN cord-019043-cqmqwl3i 34 35 ( ( -LRB- cord-019043-cqmqwl3i 34 36 i.e. i.e. FW cord-019043-cqmqwl3i 34 37 , , , cord-019043-cqmqwl3i 34 38 rapid rapid JJ cord-019043-cqmqwl3i 34 39 fluid-/electrolyte fluid-/electrolyte RB cord-019043-cqmqwl3i 34 40 - - HYPH cord-019043-cqmqwl3i 34 41 related relate VBN cord-019043-cqmqwl3i 34 42 shifts shift NNS cord-019043-cqmqwl3i 34 43 ) ) -RRB- cord-019043-cqmqwl3i 34 44 . . . cord-019043-cqmqwl3i 35 1 Surprisingly surprisingly RB cord-019043-cqmqwl3i 35 2 , , , cord-019043-cqmqwl3i 35 3 the the DT cord-019043-cqmqwl3i 35 4 early early JJ cord-019043-cqmqwl3i 35 5 mortality mortality NN cord-019043-cqmqwl3i 35 6 for for IN cord-019043-cqmqwl3i 35 7 critically critically RB cord-019043-cqmqwl3i 35 8 ill ill JJ cord-019043-cqmqwl3i 35 9 ESRD ESRD NNP cord-019043-cqmqwl3i 35 10 patients patient NNS cord-019043-cqmqwl3i 35 11 is be VBZ cord-019043-cqmqwl3i 35 12 lower low JJR cord-019043-cqmqwl3i 35 13 than than IN cord-019043-cqmqwl3i 35 14 for for IN cord-019043-cqmqwl3i 35 15 those those DT cord-019043-cqmqwl3i 35 16 with with IN cord-019043-cqmqwl3i 35 17 acute acute JJ cord-019043-cqmqwl3i 35 18 kidney kidney NN cord-019043-cqmqwl3i 35 19 injury injury NN cord-019043-cqmqwl3i 35 20 ( ( -LRB- cord-019043-cqmqwl3i 35 21 AKI AKI NNP cord-019043-cqmqwl3i 35 22 ) ) -RRB- cord-019043-cqmqwl3i 35 23 , , , cord-019043-cqmqwl3i 35 24 suggesting suggest VBG cord-019043-cqmqwl3i 35 25 that that IN cord-019043-cqmqwl3i 35 26 the the DT cord-019043-cqmqwl3i 35 27 prognosis prognosis NN cord-019043-cqmqwl3i 35 28 is be VBZ cord-019043-cqmqwl3i 35 29 driven drive VBN cord-019043-cqmqwl3i 35 30 largely largely RB cord-019043-cqmqwl3i 35 31 by by IN cord-019043-cqmqwl3i 35 32 acute acute JJ cord-019043-cqmqwl3i 35 33 illness illness NN cord-019043-cqmqwl3i 35 34 severity severity NN cord-019043-cqmqwl3i 35 35 rather rather RB cord-019043-cqmqwl3i 35 36 than than IN cord-019043-cqmqwl3i 35 37 baseline baseline JJ cord-019043-cqmqwl3i 35 38 comorbidities comorbiditie NNS cord-019043-cqmqwl3i 35 39 . . . cord-019043-cqmqwl3i 36 1 However however RB cord-019043-cqmqwl3i 36 2 , , , cord-019043-cqmqwl3i 36 3 ESRD ESRD NNP cord-019043-cqmqwl3i 36 4 patients patient NNS cord-019043-cqmqwl3i 36 5 have have VBP cord-019043-cqmqwl3i 36 6 consistently consistently RB cord-019043-cqmqwl3i 36 7 higher high JJR cord-019043-cqmqwl3i 36 8 shortterm shortterm JJ cord-019043-cqmqwl3i 36 9 mortality mortality NN cord-019043-cqmqwl3i 36 10 rates rate NNS cord-019043-cqmqwl3i 36 11 ( ( -LRB- cord-019043-cqmqwl3i 36 12 9 9 CD cord-019043-cqmqwl3i 36 13 - - SYM cord-019043-cqmqwl3i 36 14 44 44 CD cord-019043-cqmqwl3i 36 15 % % NN cord-019043-cqmqwl3i 36 16 ) ) -RRB- cord-019043-cqmqwl3i 36 17 when when WRB cord-019043-cqmqwl3i 36 18 compared compare VBN cord-019043-cqmqwl3i 36 19 to to IN cord-019043-cqmqwl3i 36 20 non non JJ cord-019043-cqmqwl3i 36 21 - - JJ cord-019043-cqmqwl3i 36 22 AKI AKI NNP cord-019043-cqmqwl3i 36 23 critically critically RB cord-019043-cqmqwl3i 36 24 ill ill VBP cord-019043-cqmqwl3i 36 25 patients patient NNS cord-019043-cqmqwl3i 36 26 and and CC cord-019043-cqmqwl3i 36 27 an an DT cord-019043-cqmqwl3i 36 28 ageand ageand NN cord-019043-cqmqwl3i 36 29 sex sex NN cord-019043-cqmqwl3i 36 30 - - HYPH cord-019043-cqmqwl3i 36 31 matched match VBN cord-019043-cqmqwl3i 36 32 general general JJ cord-019043-cqmqwl3i 36 33 population population NN cord-019043-cqmqwl3i 36 34 . . . cord-019043-cqmqwl3i 37 1 Factors factor NNS cord-019043-cqmqwl3i 37 2 that that WDT cord-019043-cqmqwl3i 37 3 have have VBP cord-019043-cqmqwl3i 37 4 been be VBN cord-019043-cqmqwl3i 37 5 shown show VBN cord-019043-cqmqwl3i 37 6 to to TO cord-019043-cqmqwl3i 37 7 be be VB cord-019043-cqmqwl3i 37 8 associated associate VBN cord-019043-cqmqwl3i 37 9 with with IN cord-019043-cqmqwl3i 37 10 ICU ICU NNP cord-019043-cqmqwl3i 37 11 mortality mortality NN cord-019043-cqmqwl3i 37 12 in in IN cord-019043-cqmqwl3i 37 13 ESRD ESRD NNP cord-019043-cqmqwl3i 37 14 patients patient NNS cord-019043-cqmqwl3i 37 15 are be VBP cord-019043-cqmqwl3i 37 16 older old JJR cord-019043-cqmqwl3i 37 17 age age NN cord-019043-cqmqwl3i 37 18 , , , cord-019043-cqmqwl3i 37 19 higher high JJR cord-019043-cqmqwl3i 37 20 illness illness NN cord-019043-cqmqwl3i 37 21 severity severity NN cord-019043-cqmqwl3i 37 22 score score NN cord-019043-cqmqwl3i 37 23 ( ( -LRB- cord-019043-cqmqwl3i 37 24 i.e. i.e. FW cord-019043-cqmqwl3i 37 25 , , , cord-019043-cqmqwl3i 37 26 APACHE APACHE NNP cord-019043-cqmqwl3i 37 27 II II NNP cord-019043-cqmqwl3i 37 28 or or CC cord-019043-cqmqwl3i 37 29 SAPS SAPS NNP cord-019043-cqmqwl3i 37 30 II II NNP cord-019043-cqmqwl3i 37 31 ) ) -RRB- cord-019043-cqmqwl3i 37 32 , , , cord-019043-cqmqwl3i 37 33 burden burden NN cord-019043-cqmqwl3i 37 34 of of IN cord-019043-cqmqwl3i 37 35 nonrenal nonrenal JJ cord-019043-cqmqwl3i 37 36 organ organ NNP cord-019043-cqmqwl3i 37 37 dysfunction dysfunction NN cord-019043-cqmqwl3i 37 38 / / SYM cord-019043-cqmqwl3i 37 39 failure failure NN cord-019043-cqmqwl3i 37 40 , , , cord-019043-cqmqwl3i 37 41 medical medical JJ cord-019043-cqmqwl3i 37 42 or or CC cord-019043-cqmqwl3i 37 43 nonsurgical nonsurgical JJ cord-019043-cqmqwl3i 37 44 admission admission NN cord-019043-cqmqwl3i 37 45 type type NN cord-019043-cqmqwl3i 37 46 , , , cord-019043-cqmqwl3i 37 47 and and CC cord-019043-cqmqwl3i 37 48 provision provision NN cord-019043-cqmqwl3i 37 49 and and CC cord-019043-cqmqwl3i 37 50 duration duration NN cord-019043-cqmqwl3i 37 51 of of IN cord-019043-cqmqwl3i 37 52 life life NN cord-019043-cqmqwl3i 37 53 - - HYPH cord-019043-cqmqwl3i 37 54 sustaining sustain VBG cord-019043-cqmqwl3i 37 55 technologies technology NNS cord-019043-cqmqwl3i 37 56 ( ( -LRB- cord-019043-cqmqwl3i 37 57 i.e. i.e. FW cord-019043-cqmqwl3i 37 58 , , , cord-019043-cqmqwl3i 37 59 mechanical mechanical JJ cord-019043-cqmqwl3i 37 60 ventilation ventilation NN cord-019043-cqmqwl3i 37 61 , , , cord-019043-cqmqwl3i 37 62 vasopressor vasopressor NN cord-019043-cqmqwl3i 37 63 therapy therapy NN cord-019043-cqmqwl3i 37 64 ) ) -RRB- cord-019043-cqmqwl3i 37 65 . . . cord-019043-cqmqwl3i 38 1 Studies study NNS cord-019043-cqmqwl3i 38 2 reporting report VBG cord-019043-cqmqwl3i 38 3 long long JJ cord-019043-cqmqwl3i 38 4 - - HYPH cord-019043-cqmqwl3i 38 5 term term NN cord-019043-cqmqwl3i 38 6 survival survival NN cord-019043-cqmqwl3i 38 7 among among IN cord-019043-cqmqwl3i 38 8 ESRD ESRD NNP cord-019043-cqmqwl3i 38 9 patients patient NNS cord-019043-cqmqwl3i 38 10 show show VBP cord-019043-cqmqwl3i 38 11 a a DT cord-019043-cqmqwl3i 38 12 trend trend NN cord-019043-cqmqwl3i 38 13 for for IN cord-019043-cqmqwl3i 38 14 an an DT cord-019043-cqmqwl3i 38 15 increased increase VBN cord-019043-cqmqwl3i 38 16 mortality mortality NN cord-019043-cqmqwl3i 38 17 rate rate NN cord-019043-cqmqwl3i 38 18 within within IN cord-019043-cqmqwl3i 38 19 the the DT cord-019043-cqmqwl3i 38 20 first first JJ cord-019043-cqmqwl3i 38 21 6 6 CD cord-019043-cqmqwl3i 38 22 months month NNS cord-019043-cqmqwl3i 38 23 after after IN cord-019043-cqmqwl3i 38 24 ICU ICU NNP cord-019043-cqmqwl3i 38 25 discharge discharge NN cord-019043-cqmqwl3i 38 26 , , , cord-019043-cqmqwl3i 38 27 with with IN cord-019043-cqmqwl3i 38 28 a a DT cord-019043-cqmqwl3i 38 29 relatively relatively RB cord-019043-cqmqwl3i 38 30 stable stable JJ cord-019043-cqmqwl3i 38 31 but but CC cord-019043-cqmqwl3i 38 32 increased increased JJ cord-019043-cqmqwl3i 38 33 risk risk NN cord-019043-cqmqwl3i 38 34 for for IN cord-019043-cqmqwl3i 38 35 mortality mortality NN cord-019043-cqmqwl3i 38 36 thereafter thereafter RB cord-019043-cqmqwl3i 38 37 . . . cord-019043-cqmqwl3i 39 1 At at IN cord-019043-cqmqwl3i 39 2 2 2 CD cord-019043-cqmqwl3i 39 3 years year NNS cord-019043-cqmqwl3i 39 4 after after IN cord-019043-cqmqwl3i 39 5 ICU ICU NNP cord-019043-cqmqwl3i 39 6 admission admission NN cord-019043-cqmqwl3i 39 7 , , , cord-019043-cqmqwl3i 39 8 survival survival NN cord-019043-cqmqwl3i 39 9 is be VBZ cord-019043-cqmqwl3i 39 10 generally generally RB cord-019043-cqmqwl3i 39 11 poor poor JJ cord-019043-cqmqwl3i 39 12 . . . cord-019043-cqmqwl3i 40 1 Observational observational JJ cord-019043-cqmqwl3i 40 2 studies study NNS cord-019043-cqmqwl3i 40 3 estimate estimate VBP cord-019043-cqmqwl3i 40 4 only only RB cord-019043-cqmqwl3i 40 5 1/3 1/3 CD cord-019043-cqmqwl3i 40 6 of of IN cord-019043-cqmqwl3i 40 7 ESRD ESRD NNP cord-019043-cqmqwl3i 40 8 patients patient NNS cord-019043-cqmqwl3i 40 9 admitted admit VBN cord-019043-cqmqwl3i 40 10 to to IN cord-019043-cqmqwl3i 40 11 ICU ICU NNP cord-019043-cqmqwl3i 40 12 were be VBD cord-019043-cqmqwl3i 40 13 still still RB cord-019043-cqmqwl3i 40 14 alive alive JJ cord-019043-cqmqwl3i 40 15 . . . cord-019043-cqmqwl3i 41 1 Although although IN cord-019043-cqmqwl3i 41 2 long long JJ cord-019043-cqmqwl3i 41 3 - - HYPH cord-019043-cqmqwl3i 41 4 term term NN cord-019043-cqmqwl3i 41 5 mortality mortality NN cord-019043-cqmqwl3i 41 6 in in IN cord-019043-cqmqwl3i 41 7 ESRD ESRD NNP cord-019043-cqmqwl3i 41 8 patients patient NNS cord-019043-cqmqwl3i 41 9 is be VBZ cord-019043-cqmqwl3i 41 10 several several JJ cord-019043-cqmqwl3i 41 11 times time NNS cord-019043-cqmqwl3i 41 12 higher high JJR cord-019043-cqmqwl3i 41 13 when when WRB cord-019043-cqmqwl3i 41 14 compared compare VBN cord-019043-cqmqwl3i 41 15 to to IN cord-019043-cqmqwl3i 41 16 the the DT cord-019043-cqmqwl3i 41 17 general general JJ cord-019043-cqmqwl3i 41 18 population population NN cord-019043-cqmqwl3i 41 19 , , , cord-019043-cqmqwl3i 41 20 the the DT cord-019043-cqmqwl3i 41 21 presence presence NN cord-019043-cqmqwl3i 41 22 of of IN cord-019043-cqmqwl3i 41 23 ESRD ESRD NNP cord-019043-cqmqwl3i 41 24 does do VBZ cord-019043-cqmqwl3i 41 25 not not RB cord-019043-cqmqwl3i 41 26 appear appear VB cord-019043-cqmqwl3i 41 27 to to TO cord-019043-cqmqwl3i 41 28 independently independently RB cord-019043-cqmqwl3i 41 29 predict predict VB cord-019043-cqmqwl3i 41 30 long long JJ cord-019043-cqmqwl3i 41 31 - - HYPH cord-019043-cqmqwl3i 41 32 term term NN cord-019043-cqmqwl3i 41 33 mortality mortality NN cord-019043-cqmqwl3i 41 34 , , , cord-019043-cqmqwl3i 41 35 suggesting suggest VBG cord-019043-cqmqwl3i 41 36 short short JJ cord-019043-cqmqwl3i 41 37 - - HYPH cord-019043-cqmqwl3i 41 38 term term NN cord-019043-cqmqwl3i 41 39 prognosis prognosis NN cord-019043-cqmqwl3i 41 40 is be VBZ cord-019043-cqmqwl3i 41 41 more more RBR cord-019043-cqmqwl3i 41 42 related related JJ cord-019043-cqmqwl3i 41 43 to to IN cord-019043-cqmqwl3i 41 44 the the DT cord-019043-cqmqwl3i 41 45 acute acute JJ cord-019043-cqmqwl3i 41 46 illness illness NN cord-019043-cqmqwl3i 41 47 severity severity NN cord-019043-cqmqwl3i 41 48 rather rather RB cord-019043-cqmqwl3i 41 49 than than IN cord-019043-cqmqwl3i 41 50 CKD CKD NNP cord-019043-cqmqwl3i 41 51 and and CC cord-019043-cqmqwl3i 41 52 dialysis dialysis NN cord-019043-cqmqwl3i 41 53 dependence dependence NN cord-019043-cqmqwl3i 41 54 . . . cord-019043-cqmqwl3i 42 1 It -PRON- PRP cord-019043-cqmqwl3i 42 2 has have VBZ cord-019043-cqmqwl3i 42 3 been be VBN cord-019043-cqmqwl3i 42 4 increasingly increasingly RB cord-019043-cqmqwl3i 42 5 recognized recognize VBN cord-019043-cqmqwl3i 42 6 that that IN cord-019043-cqmqwl3i 42 7 CKD CKD NNP cord-019043-cqmqwl3i 42 8 influences influence VBZ cord-019043-cqmqwl3i 42 9 the the DT cord-019043-cqmqwl3i 42 10 risk risk NN cord-019043-cqmqwl3i 42 11 of of IN cord-019043-cqmqwl3i 42 12 developing develop VBG cord-019043-cqmqwl3i 42 13 AKI AKI NNP cord-019043-cqmqwl3i 42 14 and and CC cord-019043-cqmqwl3i 42 15 that that IN cord-019043-cqmqwl3i 42 16 AKI AKI NNP cord-019043-cqmqwl3i 42 17 per per FW cord-019043-cqmqwl3i 42 18 se se FW cord-019043-cqmqwl3i 42 19 contributes contribute VBZ cord-019043-cqmqwl3i 42 20 to to IN cord-019043-cqmqwl3i 42 21 CKD CKD NNP cord-019043-cqmqwl3i 42 22 progression progression NN cord-019043-cqmqwl3i 42 23 and and CC cord-019043-cqmqwl3i 42 24 incidence incidence NN cord-019043-cqmqwl3i 42 25 of of IN cord-019043-cqmqwl3i 42 26 ESRD ESRD NNP cord-019043-cqmqwl3i 42 27 . . . cord-019043-cqmqwl3i 43 1 Around around IN cord-019043-cqmqwl3i 43 2 50 50 CD cord-019043-cqmqwl3i 43 3 % % NN cord-019043-cqmqwl3i 43 4 of of IN cord-019043-cqmqwl3i 43 5 patients patient NNS cord-019043-cqmqwl3i 43 6 who who WP cord-019043-cqmqwl3i 43 7 survive survive VBP cord-019043-cqmqwl3i 43 8 an an DT cord-019043-cqmqwl3i 43 9 episode episode NN cord-019043-cqmqwl3i 43 10 of of IN cord-019043-cqmqwl3i 43 11 AKI AKI NNP cord-019043-cqmqwl3i 43 12 requiring require VBG cord-019043-cqmqwl3i 43 13 RRT RRT NNP cord-019043-cqmqwl3i 43 14 show show VBP cord-019043-cqmqwl3i 43 15 significant significant JJ cord-019043-cqmqwl3i 43 16 loss loss NN cord-019043-cqmqwl3i 43 17 of of IN cord-019043-cqmqwl3i 43 18 glomerular glomerular JJ cord-019043-cqmqwl3i 43 19 filtration filtration NN cord-019043-cqmqwl3i 43 20 rate rate NN cord-019043-cqmqwl3i 43 21 ( ( -LRB- cord-019043-cqmqwl3i 43 22 GFR GFR NNP cord-019043-cqmqwl3i 43 23 ) ) -RRB- cord-019043-cqmqwl3i 43 24 resulting result VBG cord-019043-cqmqwl3i 43 25 in in IN cord-019043-cqmqwl3i 43 26 dialysis dialysis NN cord-019043-cqmqwl3i 43 27 dependence dependence NN cord-019043-cqmqwl3i 43 28 after after IN cord-019043-cqmqwl3i 43 29 hospital hospital NN cord-019043-cqmqwl3i 43 30 discharge discharge NN cord-019043-cqmqwl3i 43 31 in in IN cord-019043-cqmqwl3i 43 32 approximately approximately RB cord-019043-cqmqwl3i 43 33 10 10 CD cord-019043-cqmqwl3i 43 34 % % NN cord-019043-cqmqwl3i 43 35 of of IN cord-019043-cqmqwl3i 43 36 patients patient NNS cord-019043-cqmqwl3i 43 37 . . . cord-019043-cqmqwl3i 44 1 The the DT cord-019043-cqmqwl3i 44 2 most most RBS cord-019043-cqmqwl3i 44 3 important important JJ cord-019043-cqmqwl3i 44 4 risk risk NN cord-019043-cqmqwl3i 44 5 factor factor NN cord-019043-cqmqwl3i 44 6 for for IN cord-019043-cqmqwl3i 44 7 incident incident NN cord-019043-cqmqwl3i 44 8 ESRD ESRD NNP cord-019043-cqmqwl3i 44 9 and and CC cord-019043-cqmqwl3i 44 10 dialysis dialysis NN cord-019043-cqmqwl3i 44 11 dependence dependence NN cord-019043-cqmqwl3i 44 12 among among IN cord-019043-cqmqwl3i 44 13 survivors survivor NNS cord-019043-cqmqwl3i 44 14 of of IN cord-019043-cqmqwl3i 44 15 critical critical JJ cord-019043-cqmqwl3i 44 16 illness illness NN cord-019043-cqmqwl3i 44 17 is be VBZ cord-019043-cqmqwl3i 44 18 prior prior JJ cord-019043-cqmqwl3i 44 19 CKD CKD NNP cord-019043-cqmqwl3i 44 20 . . . cord-019043-cqmqwl3i 45 1 This this DT cord-019043-cqmqwl3i 45 2 would would MD cord-019043-cqmqwl3i 45 3 suggest suggest VB cord-019043-cqmqwl3i 45 4 continued continued JJ cord-019043-cqmqwl3i 45 5 surveillance surveillance NN cord-019043-cqmqwl3i 45 6 of of IN cord-019043-cqmqwl3i 45 7 kidney kidney NN cord-019043-cqmqwl3i 45 8 function function NN cord-019043-cqmqwl3i 45 9 among among IN cord-019043-cqmqwl3i 45 10 survivors survivor NNS cord-019043-cqmqwl3i 45 11 of of IN cord-019043-cqmqwl3i 45 12 critical critical JJ cord-019043-cqmqwl3i 45 13 illness illness NN cord-019043-cqmqwl3i 45 14 is be VBZ cord-019043-cqmqwl3i 45 15 vital vital JJ cord-019043-cqmqwl3i 45 16 . . . cord-019043-cqmqwl3i 46 1 Data datum NNS cord-019043-cqmqwl3i 46 2 on on IN cord-019043-cqmqwl3i 46 3 changes change NNS cord-019043-cqmqwl3i 46 4 to to IN cord-019043-cqmqwl3i 46 5 functional functional JJ cord-019043-cqmqwl3i 46 6 status status NN cord-019043-cqmqwl3i 46 7 and and CC cord-019043-cqmqwl3i 46 8 health health NN cord-019043-cqmqwl3i 46 9 - - HYPH cord-019043-cqmqwl3i 46 10 related relate VBN cord-019043-cqmqwl3i 46 11 quality quality NN cord-019043-cqmqwl3i 46 12 of of IN cord-019043-cqmqwl3i 46 13 life life NN cord-019043-cqmqwl3i 46 14 ( ( -LRB- cord-019043-cqmqwl3i 46 15 HRQL HRQL NNP cord-019043-cqmqwl3i 46 16 ) ) -RRB- cord-019043-cqmqwl3i 46 17 for for IN cord-019043-cqmqwl3i 46 18 ESRD ESRD NNP cord-019043-cqmqwl3i 46 19 patients patient NNS cord-019043-cqmqwl3i 46 20 surviving survive VBG cord-019043-cqmqwl3i 46 21 an an DT cord-019043-cqmqwl3i 46 22 episode episode NN cord-019043-cqmqwl3i 46 23 of of IN cord-019043-cqmqwl3i 46 24 critical critical JJ cord-019043-cqmqwl3i 46 25 illness illness NN cord-019043-cqmqwl3i 46 26 are be VBP cord-019043-cqmqwl3i 46 27 currently currently RB cord-019043-cqmqwl3i 46 28 lacking lack VBG cord-019043-cqmqwl3i 46 29 . . . cord-019043-cqmqwl3i 47 1 However however RB cord-019043-cqmqwl3i 47 2 , , , cord-019043-cqmqwl3i 47 3 in in IN cord-019043-cqmqwl3i 47 4 non non JJ cord-019043-cqmqwl3i 47 5 - - JJ cord-019043-cqmqwl3i 47 6 ESRD esrd JJ cord-019043-cqmqwl3i 47 7 critically critically RB cord-019043-cqmqwl3i 47 8 ill ill VBP cord-019043-cqmqwl3i 47 9 patients patient NNS cord-019043-cqmqwl3i 47 10 surviving survive VBG cord-019043-cqmqwl3i 47 11 critical critical JJ cord-019043-cqmqwl3i 47 12 illness illness NN cord-019043-cqmqwl3i 47 13 , , , cord-019043-cqmqwl3i 47 14 in in IN cord-019043-cqmqwl3i 47 15 particular particular JJ cord-019043-cqmqwl3i 47 16 for for IN cord-019043-cqmqwl3i 47 17 those those DT cord-019043-cqmqwl3i 47 18 with with IN cord-019043-cqmqwl3i 47 19 severe severe JJ cord-019043-cqmqwl3i 47 20 AKI AKI NNP cord-019043-cqmqwl3i 47 21 requiring require VBG cord-019043-cqmqwl3i 47 22 acute acute JJ cord-019043-cqmqwl3i 47 23 RRT rrt NN cord-019043-cqmqwl3i 47 24 , , , cord-019043-cqmqwl3i 47 25 long long JJ cord-019043-cqmqwl3i 47 26 - - HYPH cord-019043-cqmqwl3i 47 27 term term NN cord-019043-cqmqwl3i 47 28 reductions reduction NNS cord-019043-cqmqwl3i 47 29 in in IN cord-019043-cqmqwl3i 47 30 HRQL HRQL NNS cord-019043-cqmqwl3i 47 31 and and CC cord-019043-cqmqwl3i 47 32 impaired impair VBN cord-019043-cqmqwl3i 47 33 functional functional JJ cord-019043-cqmqwl3i 47 34 status status NN cord-019043-cqmqwl3i 47 35 are be VBP cord-019043-cqmqwl3i 47 36 common common JJ cord-019043-cqmqwl3i 47 37 . . . cord-019043-cqmqwl3i 48 1 These these DT cord-019043-cqmqwl3i 48 2 data datum NNS cord-019043-cqmqwl3i 48 3 coupled couple VBN cord-019043-cqmqwl3i 48 4 with with IN cord-019043-cqmqwl3i 48 5 the the DT cord-019043-cqmqwl3i 48 6 reduced reduce VBN cord-019043-cqmqwl3i 48 7 HRQL HRQL NNS cord-019043-cqmqwl3i 48 8 for for IN cord-019043-cqmqwl3i 48 9 ESRD ESRD NNP cord-019043-cqmqwl3i 48 10 patients patient NNS cord-019043-cqmqwl3i 48 11 imply imply VBP cord-019043-cqmqwl3i 48 12 this this DT cord-019043-cqmqwl3i 48 13 may may MD cord-019043-cqmqwl3i 48 14 be be VB cord-019043-cqmqwl3i 48 15 a a DT cord-019043-cqmqwl3i 48 16 significant significant JJ cord-019043-cqmqwl3i 48 17 issue issue NN cord-019043-cqmqwl3i 48 18 for for IN cord-019043-cqmqwl3i 48 19 survivors survivor NNS cord-019043-cqmqwl3i 48 20 of of IN cord-019043-cqmqwl3i 48 21 critical critical JJ cord-019043-cqmqwl3i 48 22 illness illness NN cord-019043-cqmqwl3i 48 23 . . . cord-019043-cqmqwl3i 49 1 CKD CKD NNP cord-019043-cqmqwl3i 49 2 , , , cord-019043-cqmqwl3i 49 3 in in IN cord-019043-cqmqwl3i 49 4 particular particular JJ cord-019043-cqmqwl3i 49 5 ESRD ESRD NNP cord-019043-cqmqwl3i 49 6 patients patient NNS cord-019043-cqmqwl3i 49 7 , , , cord-019043-cqmqwl3i 49 8 consume consume VB cord-019043-cqmqwl3i 49 9 more more JJR cord-019043-cqmqwl3i 49 10 health health NN cord-019043-cqmqwl3i 49 11 resources resource NNS cord-019043-cqmqwl3i 49 12 in in IN cord-019043-cqmqwl3i 49 13 association association NN cord-019043-cqmqwl3i 49 14 with with IN cord-019043-cqmqwl3i 49 15 admission admission NN cord-019043-cqmqwl3i 49 16 to to IN cord-019043-cqmqwl3i 49 17 ICU ICU NNP cord-019043-cqmqwl3i 49 18 compared compare VBN cord-019043-cqmqwl3i 49 19 with with IN cord-019043-cqmqwl3i 49 20 non non JJ cord-019043-cqmqwl3i 49 21 - - JJ cord-019043-cqmqwl3i 49 22 CKD ckd JJ cord-019043-cqmqwl3i 49 23 patients patient NNS cord-019043-cqmqwl3i 49 24 . . . cord-019043-cqmqwl3i 50 1 These these DT cord-019043-cqmqwl3i 50 2 patients patient NNS cord-019043-cqmqwl3i 50 3 have have VBP cord-019043-cqmqwl3i 50 4 longer long JJR cord-019043-cqmqwl3i 50 5 durations duration NNS cord-019043-cqmqwl3i 50 6 of of IN cord-019043-cqmqwl3i 50 7 ICU ICU NNP cord-019043-cqmqwl3i 50 8 stay stay VBP cord-019043-cqmqwl3i 50 9 , , , cord-019043-cqmqwl3i 50 10 longer long JJR cord-019043-cqmqwl3i 50 11 duration duration NN cord-019043-cqmqwl3i 50 12 of of IN cord-019043-cqmqwl3i 50 13 hospitalization hospitalization NN cord-019043-cqmqwl3i 50 14 , , , cord-019043-cqmqwl3i 50 15 and and CC cord-019043-cqmqwl3i 50 16 higher high JJR cord-019043-cqmqwl3i 50 17 rates rate NNS cord-019043-cqmqwl3i 50 18 of of IN cord-019043-cqmqwl3i 50 19 short short JJ cord-019043-cqmqwl3i 50 20 - - HYPH cord-019043-cqmqwl3i 50 21 term term NN cord-019043-cqmqwl3i 50 22 rehospitalization rehospitalization NN cord-019043-cqmqwl3i 50 23 . . . cord-019043-cqmqwl3i 51 1 Moreover moreover RB cord-019043-cqmqwl3i 51 2 , , , cord-019043-cqmqwl3i 51 3 these these DT cord-019043-cqmqwl3i 51 4 patients patient NNS cord-019043-cqmqwl3i 51 5 often often RB cord-019043-cqmqwl3i 51 6 remain remain VBP cord-019043-cqmqwl3i 51 7 chronically chronically RB cord-019043-cqmqwl3i 51 8 ill ill RB cord-019043-cqmqwl3i 51 9 following follow VBG cord-019043-cqmqwl3i 51 10 ICU ICU NNP cord-019043-cqmqwl3i 51 11 discharge discharge NN cord-019043-cqmqwl3i 51 12 due due IN cord-019043-cqmqwl3i 51 13 to to IN cord-019043-cqmqwl3i 51 14 issues issue NNS cord-019043-cqmqwl3i 51 15 related relate VBN cord-019043-cqmqwl3i 51 16 to to IN cord-019043-cqmqwl3i 51 17 cardiovascular cardiovascular JJ cord-019043-cqmqwl3i 51 18 comorbidity comorbidity NN cord-019043-cqmqwl3i 51 19 , , , cord-019043-cqmqwl3i 51 20 malnutrition malnutrition NN cord-019043-cqmqwl3i 51 21 , , , cord-019043-cqmqwl3i 51 22 and and CC cord-019043-cqmqwl3i 51 23 deconditioning deconditioning NN cord-019043-cqmqwl3i 51 24 . . . cord-019043-cqmqwl3i 52 1 These these DT cord-019043-cqmqwl3i 52 2 likely likely RB cord-019043-cqmqwl3i 52 3 reflect reflect VBP cord-019043-cqmqwl3i 52 4 diminished diminish VBN cord-019043-cqmqwl3i 52 5 physiologic physiologic JJ cord-019043-cqmqwl3i 52 6 reserve reserve NN cord-019043-cqmqwl3i 52 7 and and CC cord-019043-cqmqwl3i 52 8 increased increase VBN cord-019043-cqmqwl3i 52 9 vulnerability vulnerability NN cord-019043-cqmqwl3i 52 10 to to IN cord-019043-cqmqwl3i 52 11 further further JJ cord-019043-cqmqwl3i 52 12 adverse adverse JJ cord-019043-cqmqwl3i 52 13 events event NNS cord-019043-cqmqwl3i 52 14 . . . cord-019043-cqmqwl3i 53 1 ICU ICU NNP cord-019043-cqmqwl3i 53 2 prognostication prognostication NN cord-019043-cqmqwl3i 53 3 using use VBG cord-019043-cqmqwl3i 53 4 ICU ICU NNP cord-019043-cqmqwl3i 53 5 - - HYPH cord-019043-cqmqwl3i 53 6 specific specific JJ cord-019043-cqmqwl3i 53 7 illness illness NN cord-019043-cqmqwl3i 53 8 severity severity NN cord-019043-cqmqwl3i 53 9 or or CC cord-019043-cqmqwl3i 53 10 organ organ NN cord-019043-cqmqwl3i 53 11 failure failure NN cord-019043-cqmqwl3i 53 12 scores score NNS cord-019043-cqmqwl3i 53 13 ( ( -LRB- cord-019043-cqmqwl3i 53 14 i.e. i.e. FW cord-019043-cqmqwl3i 53 15 , , , cord-019043-cqmqwl3i 53 16 APAHCE APAHCE NNP cord-019043-cqmqwl3i 53 17 II II NNP cord-019043-cqmqwl3i 53 18 , , , cord-019043-cqmqwl3i 53 19 SAPS SAPS NNP cord-019043-cqmqwl3i 53 20 III III NNP cord-019043-cqmqwl3i 53 21 , , , cord-019043-cqmqwl3i 53 22 SOFA sofa NN cord-019043-cqmqwl3i 53 23 ) ) -RRB- cord-019043-cqmqwl3i 53 24 can can MD cord-019043-cqmqwl3i 53 25 be be VB cord-019043-cqmqwl3i 53 26 challenging challenging JJ cord-019043-cqmqwl3i 53 27 among among IN cord-019043-cqmqwl3i 53 28 patients patient NNS cord-019043-cqmqwl3i 53 29 with with IN cord-019043-cqmqwl3i 53 30 ESRD ESRD NNP cord-019043-cqmqwl3i 53 31 . . . cord-019043-cqmqwl3i 54 1 Most Most JJS cord-019043-cqmqwl3i 54 2 scoring scoring NN cord-019043-cqmqwl3i 54 3 systems system NNS cord-019043-cqmqwl3i 54 4 have have VBP cord-019043-cqmqwl3i 54 5 not not RB cord-019043-cqmqwl3i 54 6 been be VBN cord-019043-cqmqwl3i 54 7 specifically specifically RB cord-019043-cqmqwl3i 54 8 validated validate VBN cord-019043-cqmqwl3i 54 9 for for IN cord-019043-cqmqwl3i 54 10 ESRD ESRD NNP cord-019043-cqmqwl3i 54 11 patients patient NNS cord-019043-cqmqwl3i 54 12 , , , cord-019043-cqmqwl3i 54 13 and and CC cord-019043-cqmqwl3i 54 14 their -PRON- PRP$ cord-019043-cqmqwl3i 54 15 performance performance NN cord-019043-cqmqwl3i 54 16 routinely routinely RB cord-019043-cqmqwl3i 54 17 overestimates overestimate VBZ cord-019043-cqmqwl3i 54 18 the the DT cord-019043-cqmqwl3i 54 19 risk risk NN cord-019043-cqmqwl3i 54 20 of of IN cord-019043-cqmqwl3i 54 21 death death NN cord-019043-cqmqwl3i 54 22 [ [ -LRB- cord-019043-cqmqwl3i 54 23 1 1 CD cord-019043-cqmqwl3i 54 24 ] ] -RRB- cord-019043-cqmqwl3i 54 25 . . . cord-019043-cqmqwl3i 55 1 This this DT cord-019043-cqmqwl3i 55 2 may may MD cord-019043-cqmqwl3i 55 3 contribute contribute VB cord-019043-cqmqwl3i 55 4 to to IN cord-019043-cqmqwl3i 55 5 the the DT cord-019043-cqmqwl3i 55 6 perceived perceived JJ cord-019043-cqmqwl3i 55 7 lack lack NN cord-019043-cqmqwl3i 55 8 of of IN cord-019043-cqmqwl3i 55 9 benefit benefit NN cord-019043-cqmqwl3i 55 10 of of IN cord-019043-cqmqwl3i 55 11 ICU ICU NNP cord-019043-cqmqwl3i 55 12 support support NN cord-019043-cqmqwl3i 55 13 for for IN cord-019043-cqmqwl3i 55 14 CKD CKD NNP cord-019043-cqmqwl3i 55 15 / / SYM cord-019043-cqmqwl3i 55 16 ESRD ESRD NNP cord-019043-cqmqwl3i 55 17 patients patient NNS cord-019043-cqmqwl3i 55 18 referred refer VBD cord-019043-cqmqwl3i 55 19 for for IN cord-019043-cqmqwl3i 55 20 ICU ICU NNP cord-019043-cqmqwl3i 55 21 support support NN cord-019043-cqmqwl3i 55 22 . . . cord-019043-cqmqwl3i 56 1 The the DT cord-019043-cqmqwl3i 56 2 pathological pathological JJ cord-019043-cqmqwl3i 56 3 changes change NNS cord-019043-cqmqwl3i 56 4 accompanying accompany VBG cord-019043-cqmqwl3i 56 5 CKD CKD NNP cord-019043-cqmqwl3i 56 6 , , , cord-019043-cqmqwl3i 56 7 although although IN cord-019043-cqmqwl3i 56 8 frequently frequently RB cord-019043-cqmqwl3i 56 9 not not RB cord-019043-cqmqwl3i 56 10 clinically clinically RB cord-019043-cqmqwl3i 56 11 evident evident JJ cord-019043-cqmqwl3i 56 12 until until IN cord-019043-cqmqwl3i 56 13 later later JJ cord-019043-cqmqwl3i 56 14 stages stage NNS cord-019043-cqmqwl3i 56 15 of of IN cord-019043-cqmqwl3i 56 16 kidney kidney NN cord-019043-cqmqwl3i 56 17 disease disease NN cord-019043-cqmqwl3i 56 18 , , , cord-019043-cqmqwl3i 56 19 can can MD cord-019043-cqmqwl3i 56 20 present present VB cord-019043-cqmqwl3i 56 21 unique unique JJ cord-019043-cqmqwl3i 56 22 challenges challenge NNS cord-019043-cqmqwl3i 56 23 for for IN cord-019043-cqmqwl3i 56 24 CKD CKD NNP cord-019043-cqmqwl3i 56 25 patients patient NNS cord-019043-cqmqwl3i 56 26 presenting present VBG cord-019043-cqmqwl3i 56 27 with with IN cord-019043-cqmqwl3i 56 28 critical critical JJ cord-019043-cqmqwl3i 56 29 illness illness NN cord-019043-cqmqwl3i 56 30 . . . cord-019043-cqmqwl3i 57 1 Details detail NNS cord-019043-cqmqwl3i 57 2 of of IN cord-019043-cqmqwl3i 57 3 some some DT cord-019043-cqmqwl3i 57 4 of of IN cord-019043-cqmqwl3i 57 5 the the DT cord-019043-cqmqwl3i 57 6 unique unique JJ cord-019043-cqmqwl3i 57 7 challenges challenge NNS cord-019043-cqmqwl3i 57 8 in in IN cord-019043-cqmqwl3i 57 9 the the DT cord-019043-cqmqwl3i 57 10 acute acute JJ cord-019043-cqmqwl3i 57 11 management management NN cord-019043-cqmqwl3i 57 12 of of IN cord-019043-cqmqwl3i 57 13 CKD CKD NNP cord-019043-cqmqwl3i 57 14 patients patient NNS cord-019043-cqmqwl3i 57 15 in in IN cord-019043-cqmqwl3i 57 16 the the DT cord-019043-cqmqwl3i 57 17 ICU ICU NNP cord-019043-cqmqwl3i 57 18 are be VBP cord-019043-cqmqwl3i 57 19 detailed detail VBN cord-019043-cqmqwl3i 57 20 in in IN cord-019043-cqmqwl3i 57 21 Table Table NNP cord-019043-cqmqwl3i 57 22 32 32 CD cord-019043-cqmqwl3i 57 23 . . . cord-019043-cqmqwl3i 58 1 1 1 LS cord-019043-cqmqwl3i 58 2 . . . cord-019043-cqmqwl3i 59 1 There there EX cord-019043-cqmqwl3i 59 2 is be VBZ cord-019043-cqmqwl3i 59 3 a a DT cord-019043-cqmqwl3i 59 4 paucity paucity NN cord-019043-cqmqwl3i 59 5 of of IN cord-019043-cqmqwl3i 59 6 data datum NNS cord-019043-cqmqwl3i 59 7 with with IN cord-019043-cqmqwl3i 59 8 respect respect NN cord-019043-cqmqwl3i 59 9 to to IN cord-019043-cqmqwl3i 59 10 the the DT cord-019043-cqmqwl3i 59 11 specificity specificity NN cord-019043-cqmqwl3i 59 12 of of IN cord-019043-cqmqwl3i 59 13 the the DT cord-019043-cqmqwl3i 59 14 management management NN cord-019043-cqmqwl3i 59 15 of of IN cord-019043-cqmqwl3i 59 16 CKD CKD NNP cord-019043-cqmqwl3i 59 17 patients patient NNS cord-019043-cqmqwl3i 59 18 in in IN cord-019043-cqmqwl3i 59 19 the the DT cord-019043-cqmqwl3i 59 20 ICU ICU NNP cord-019043-cqmqwl3i 59 21 especially especially RB cord-019043-cqmqwl3i 59 22 in in IN cord-019043-cqmqwl3i 59 23 the the DT cord-019043-cqmqwl3i 59 24 early early JJ cord-019043-cqmqwl3i 59 25 stages stage NNS cord-019043-cqmqwl3i 59 26 of of IN cord-019043-cqmqwl3i 59 27 the the DT cord-019043-cqmqwl3i 59 28 disease disease NN cord-019043-cqmqwl3i 59 29 . . . cord-019043-cqmqwl3i 60 1 CKD CKD NNP cord-019043-cqmqwl3i 60 2 patients patient NNS cord-019043-cqmqwl3i 60 3 should should MD cord-019043-cqmqwl3i 60 4 receive receive VB cord-019043-cqmqwl3i 60 5 the the DT cord-019043-cqmqwl3i 60 6 same same JJ cord-019043-cqmqwl3i 60 7 standard standard NN cord-019043-cqmqwl3i 60 8 of of IN cord-019043-cqmqwl3i 60 9 care care NN cord-019043-cqmqwl3i 60 10 as as IN cord-019043-cqmqwl3i 60 11 the the DT cord-019043-cqmqwl3i 60 12 general general JJ cord-019043-cqmqwl3i 60 13 population population NN cord-019043-cqmqwl3i 60 14 while while IN cord-019043-cqmqwl3i 60 15 accounting account VBG cord-019043-cqmqwl3i 60 16 for for IN cord-019043-cqmqwl3i 60 17 some some DT cord-019043-cqmqwl3i 60 18 of of IN cord-019043-cqmqwl3i 60 19 the the DT cord-019043-cqmqwl3i 60 20 unique unique JJ cord-019043-cqmqwl3i 60 21 challenges challenge NNS cord-019043-cqmqwl3i 60 22 that that WDT cord-019043-cqmqwl3i 60 23 patients patient NNS cord-019043-cqmqwl3i 60 24 with with IN cord-019043-cqmqwl3i 60 25 CKD CKD NNP cord-019043-cqmqwl3i 60 26 / / SYM cord-019043-cqmqwl3i 60 27 ESRD ESRD NNP cord-019043-cqmqwl3i 60 28 may may MD cord-019043-cqmqwl3i 60 29 pose pose VB cord-019043-cqmqwl3i 60 30 to to IN cord-019043-cqmqwl3i 60 31 ICU ICU NNP cord-019043-cqmqwl3i 60 32 management management NN cord-019043-cqmqwl3i 60 33 . . . cord-019043-cqmqwl3i 61 1 The the DT cord-019043-cqmqwl3i 61 2 general general JJ cord-019043-cqmqwl3i 61 3 principles principle NNS cord-019043-cqmqwl3i 61 4 for for IN cord-019043-cqmqwl3i 61 5 support support NN cord-019043-cqmqwl3i 61 6 and and CC cord-019043-cqmqwl3i 61 7 management management NN cord-019043-cqmqwl3i 61 8 of of IN cord-019043-cqmqwl3i 61 9 critically critically RB cord-019043-cqmqwl3i 61 10 ill ill JJ cord-019043-cqmqwl3i 61 11 patient patient NN cord-019043-cqmqwl3i 61 12 in in IN cord-019043-cqmqwl3i 61 13 the the DT cord-019043-cqmqwl3i 61 14 ICU ICU NNP cord-019043-cqmqwl3i 61 15 focus focus NN cord-019043-cqmqwl3i 61 16 on on IN cord-019043-cqmqwl3i 61 17 advanced advanced JJ cord-019043-cqmqwl3i 61 18 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 61 19 and and CC cord-019043-cqmqwl3i 61 20 physiologic physiologic JJ cord-019043-cqmqwl3i 61 21 monitoring monitoring NN cord-019043-cqmqwl3i 61 22 and and CC cord-019043-cqmqwl3i 61 23 multimodal multimodal NN cord-019043-cqmqwl3i 61 24 organ organ NN cord-019043-cqmqwl3i 61 25 support support NN cord-019043-cqmqwl3i 61 26 to to TO cord-019043-cqmqwl3i 61 27 guide guide VB cord-019043-cqmqwl3i 61 28 restoration restoration NN cord-019043-cqmqwl3i 61 29 of of IN cord-019043-cqmqwl3i 61 30 tissue tissue NN cord-019043-cqmqwl3i 61 31 perfusion perfusion NN cord-019043-cqmqwl3i 61 32 and and CC cord-019043-cqmqwl3i 61 33 oxygen oxygen NN cord-019043-cqmqwl3i 61 34 delivery delivery NN cord-019043-cqmqwl3i 61 35 ( ( -LRB- cord-019043-cqmqwl3i 61 36 Table Table NNP cord-019043-cqmqwl3i 61 37 32 32 CD cord-019043-cqmqwl3i 61 38 . . CD cord-019043-cqmqwl3i 61 39 2 2 CD cord-019043-cqmqwl3i 61 40 ) ) -RRB- cord-019043-cqmqwl3i 61 41 . . . cord-019043-cqmqwl3i 62 1 The the DT cord-019043-cqmqwl3i 62 2 majority majority NN cord-019043-cqmqwl3i 62 3 of of IN cord-019043-cqmqwl3i 62 4 patients patient NNS cord-019043-cqmqwl3i 62 5 have have VBP cord-019043-cqmqwl3i 62 6 intravascular intravascular JJ cord-019043-cqmqwl3i 62 7 placement placement NN cord-019043-cqmqwl3i 62 8 of of IN cord-019043-cqmqwl3i 62 9 arterial arterial JJ cord-019043-cqmqwl3i 62 10 catheter catheter NN cord-019043-cqmqwl3i 62 11 for for IN cord-019043-cqmqwl3i 62 12 continuous continuous JJ cord-019043-cqmqwl3i 62 13 blood blood NN cord-019043-cqmqwl3i 62 14 pressure pressure NN cord-019043-cqmqwl3i 62 15 monitoring monitoring NN cord-019043-cqmqwl3i 62 16 , , , cord-019043-cqmqwl3i 62 17 due due JJ cord-019043-cqmqwl3i 62 18 either either CC cord-019043-cqmqwl3i 62 19 to to IN cord-019043-cqmqwl3i 62 20 the the DT cord-019043-cqmqwl3i 62 21 presence presence NN cord-019043-cqmqwl3i 62 22 of of IN cord-019043-cqmqwl3i 62 23 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 62 24 instability instability NN cord-019043-cqmqwl3i 62 25 or or CC cord-019043-cqmqwl3i 62 26 to to IN cord-019043-cqmqwl3i 62 27 monitoring monitor VBG cord-019043-cqmqwl3i 62 28 resuscitation resuscitation NN cord-019043-cqmqwl3i 62 29 ( ( -LRB- cord-019043-cqmqwl3i 62 30 i.e. i.e. FW cord-019043-cqmqwl3i 62 31 , , , cord-019043-cqmqwl3i 62 32 fluid fluid JJ cord-019043-cqmqwl3i 62 33 therapy therapy NN cord-019043-cqmqwl3i 62 34 or or CC cord-019043-cqmqwl3i 62 35 titration titration NN cord-019043-cqmqwl3i 62 36 of of IN cord-019043-cqmqwl3i 62 37 vasoactive vasoactive JJ cord-019043-cqmqwl3i 62 38 therapy therapy NN cord-019043-cqmqwl3i 62 39 ) ) -RRB- cord-019043-cqmqwl3i 62 40 or or CC cord-019043-cqmqwl3i 62 41 need need VB cord-019043-cqmqwl3i 62 42 for for IN cord-019043-cqmqwl3i 62 43 frequent frequent JJ cord-019043-cqmqwl3i 62 44 blood blood NN cord-019043-cqmqwl3i 62 45 sampling sampling NN cord-019043-cqmqwl3i 62 46 . . . cord-019043-cqmqwl3i 63 1 Arterial arterial JJ cord-019043-cqmqwl3i 63 2 catheters catheter NNS cord-019043-cqmqwl3i 63 3 display display VBP cord-019043-cqmqwl3i 63 4 systolic systolic JJ cord-019043-cqmqwl3i 63 5 , , , cord-019043-cqmqwl3i 63 6 diastolic diastolic JJ cord-019043-cqmqwl3i 63 7 , , , cord-019043-cqmqwl3i 63 8 and and CC cord-019043-cqmqwl3i 63 9 mean mean VB cord-019043-cqmqwl3i 63 10 arterial arterial JJ cord-019043-cqmqwl3i 63 11 pressure pressure NN cord-019043-cqmqwl3i 63 12 readings reading NNS cord-019043-cqmqwl3i 63 13 along along IN cord-019043-cqmqwl3i 63 14 with with IN cord-019043-cqmqwl3i 63 15 a a DT cord-019043-cqmqwl3i 63 16 continuous continuous JJ cord-019043-cqmqwl3i 63 17 waveform waveform NN cord-019043-cqmqwl3i 63 18 . . . cord-019043-cqmqwl3i 64 1 Analysis analysis NN cord-019043-cqmqwl3i 64 2 of of IN cord-019043-cqmqwl3i 64 3 the the DT cord-019043-cqmqwl3i 64 4 pressure pressure NN cord-019043-cqmqwl3i 64 5 waveform waveform NN cord-019043-cqmqwl3i 64 6 may may MD cord-019043-cqmqwl3i 64 7 provide provide VB cord-019043-cqmqwl3i 64 8 useful useful JJ cord-019043-cqmqwl3i 64 9 information information NN cord-019043-cqmqwl3i 64 10 regarding regard VBG cord-019043-cqmqwl3i 64 11 a a DT cord-019043-cqmqwl3i 64 12 patient patient NN cord-019043-cqmqwl3i 64 13 's 's POS cord-019043-cqmqwl3i 64 14 clinical clinical JJ cord-019043-cqmqwl3i 64 15 status status NN cord-019043-cqmqwl3i 64 16 . . . cord-019043-cqmqwl3i 65 1 Variability variability NN cord-019043-cqmqwl3i 65 2 on on IN cord-019043-cqmqwl3i 65 3 pulse pulse NN cord-019043-cqmqwl3i 65 4 contours contour NNS cord-019043-cqmqwl3i 65 5 is be VBZ cord-019043-cqmqwl3i 65 6 related relate VBN cord-019043-cqmqwl3i 65 7 to to IN cord-019043-cqmqwl3i 65 8 the the DT cord-019043-cqmqwl3i 65 9 elasticity elasticity NN cord-019043-cqmqwl3i 65 10 , , , cord-019043-cqmqwl3i 65 11 amplification amplification NN cord-019043-cqmqwl3i 65 12 , , , cord-019043-cqmqwl3i 65 13 and and CC cord-019043-cqmqwl3i 65 14 distortion distortion NN cord-019043-cqmqwl3i 65 15 of of IN cord-019043-cqmqwl3i 65 16 smaller small JJR cord-019043-cqmqwl3i 65 17 peripheral peripheral JJ cord-019043-cqmqwl3i 65 18 arterioles arteriole NNS cord-019043-cqmqwl3i 65 19 . . . cord-019043-cqmqwl3i 66 1 CKD CKD NNP cord-019043-cqmqwl3i 66 2 patients patient NNS cord-019043-cqmqwl3i 66 3 with with IN cord-019043-cqmqwl3i 66 4 significant significant JJ cord-019043-cqmqwl3i 66 5 peripheral peripheral JJ cord-019043-cqmqwl3i 66 6 vascular vascular JJ cord-019043-cqmqwl3i 66 7 disease disease NN cord-019043-cqmqwl3i 67 1 and/or and/or CC cord-019043-cqmqwl3i 67 2 arteriolar arteriolar JJ cord-019043-cqmqwl3i 67 3 calcification calcification NN cord-019043-cqmqwl3i 67 4 may may MD cord-019043-cqmqwl3i 67 5 have have VB cord-019043-cqmqwl3i 67 6 reduced reduce VBN cord-019043-cqmqwl3i 67 7 vessel vessel NN cord-019043-cqmqwl3i 67 8 elasticity elasticity NN cord-019043-cqmqwl3i 67 9 ( ( -LRB- cord-019043-cqmqwl3i 67 10 i.e. i.e. FW cord-019043-cqmqwl3i 67 11 , , , cord-019043-cqmqwl3i 67 12 arterial arterial JJ cord-019043-cqmqwl3i 67 13 stiffness stiffness NN cord-019043-cqmqwl3i 67 14 ) ) -RRB- cord-019043-cqmqwl3i 67 15 and and CC cord-019043-cqmqwl3i 67 16 exacerbated exacerbate VBD cord-019043-cqmqwl3i 67 17 amplification amplification NN cord-019043-cqmqwl3i 67 18 that that WDT cord-019043-cqmqwl3i 67 19 results result VBZ cord-019043-cqmqwl3i 67 20 in in IN cord-019043-cqmqwl3i 67 21 relative relative JJ cord-019043-cqmqwl3i 67 22 increases increase NNS cord-019043-cqmqwl3i 67 23 in in IN cord-019043-cqmqwl3i 67 24 systolic systolic JJ cord-019043-cqmqwl3i 67 25 pressure pressure NN cord-019043-cqmqwl3i 67 26 and and CC cord-019043-cqmqwl3i 67 27 low low JJ cord-019043-cqmqwl3i 67 28 diastolic diastolic JJ cord-019043-cqmqwl3i 67 29 pressure pressure NN cord-019043-cqmqwl3i 67 30 with with IN cord-019043-cqmqwl3i 67 31 rapid rapid JJ cord-019043-cqmqwl3i 67 32 diastolic diastolic JJ cord-019043-cqmqwl3i 67 33 runoff runoff NN cord-019043-cqmqwl3i 67 34 ( ( -LRB- cord-019043-cqmqwl3i 67 35 i.e. i.e. FW cord-019043-cqmqwl3i 67 36 , , , cord-019043-cqmqwl3i 67 37 widened widen VBN cord-019043-cqmqwl3i 67 38 pulse pulse NN cord-019043-cqmqwl3i 67 39 pressure pressure NN cord-019043-cqmqwl3i 67 40 ) ) -RRB- cord-019043-cqmqwl3i 67 41 . . . cord-019043-cqmqwl3i 68 1 ESRD ESRD NNP cord-019043-cqmqwl3i 68 2 patients patient NNS cord-019043-cqmqwl3i 68 3 with with IN cord-019043-cqmqwl3i 68 4 a a DT cord-019043-cqmqwl3i 68 5 fistula fistula NN cord-019043-cqmqwl3i 68 6 or or CC cord-019043-cqmqwl3i 68 7 graft graft NN cord-019043-cqmqwl3i 68 8 will will MD cord-019043-cqmqwl3i 68 9 have have VB cord-019043-cqmqwl3i 68 10 accelerated accelerate VBN cord-019043-cqmqwl3i 68 11 diastolic diastolic JJ cord-019043-cqmqwl3i 68 12 runoff runoff NN cord-019043-cqmqwl3i 68 13 and and CC cord-019043-cqmqwl3i 68 14 as as IN cord-019043-cqmqwl3i 68 15 a a DT cord-019043-cqmqwl3i 68 16 consequence consequence NN cord-019043-cqmqwl3i 68 17 lower low JJR cord-019043-cqmqwl3i 68 18 diastolic diastolic JJ cord-019043-cqmqwl3i 68 19 and and CC cord-019043-cqmqwl3i 68 20 mean mean VB cord-019043-cqmqwl3i 68 21 arterial arterial JJ cord-019043-cqmqwl3i 68 22 pressure pressure NN cord-019043-cqmqwl3i 68 23 . . . cord-019043-cqmqwl3i 69 1 In in IN cord-019043-cqmqwl3i 69 2 addition addition NN cord-019043-cqmqwl3i 69 3 , , , cord-019043-cqmqwl3i 69 4 given give VBN cord-019043-cqmqwl3i 69 5 the the DT cord-019043-cqmqwl3i 69 6 prevalence prevalence NN cord-019043-cqmqwl3i 69 7 of of IN cord-019043-cqmqwl3i 69 8 comorbid comorbid NN cord-019043-cqmqwl3i 69 9 conditions condition NNS cord-019043-cqmqwl3i 69 10 in in IN cord-019043-cqmqwl3i 69 11 CKD CKD NNP cord-019043-cqmqwl3i 69 12 such such JJ cord-019043-cqmqwl3i 69 13 as as IN cord-019043-cqmqwl3i 69 14 cardiac cardiac JJ cord-019043-cqmqwl3i 69 15 valvular valvular JJ cord-019043-cqmqwl3i 69 16 disease disease NN cord-019043-cqmqwl3i 69 17 , , , cord-019043-cqmqwl3i 69 18 ventricular ventricular JJ cord-019043-cqmqwl3i 69 19 hypertrophy hypertrophy NN cord-019043-cqmqwl3i 69 20 ( ( -LRB- cord-019043-cqmqwl3i 69 21 LVH LVH NNP cord-019043-cqmqwl3i 69 22 ) ) -RRB- cord-019043-cqmqwl3i 69 23 , , , cord-019043-cqmqwl3i 69 24 or or CC cord-019043-cqmqwl3i 69 25 pulmonary pulmonary JJ cord-019043-cqmqwl3i 69 26 hypertension hypertension NN cord-019043-cqmqwl3i 69 27 , , , cord-019043-cqmqwl3i 69 28 arterial arterial JJ cord-019043-cqmqwl3i 69 29 catheters catheter NNS cord-019043-cqmqwl3i 69 30 may may MD cord-019043-cqmqwl3i 69 31 have have VB cord-019043-cqmqwl3i 69 32 misleading mislead VBG cord-019043-cqmqwl3i 69 33 instantaneous instantaneous JJ cord-019043-cqmqwl3i 69 34 accuracy accuracy NN cord-019043-cqmqwl3i 69 35 , , , cord-019043-cqmqwl3i 69 36 though though IN cord-019043-cqmqwl3i 69 37 likely likely RB cord-019043-cqmqwl3i 69 38 have have VBP cord-019043-cqmqwl3i 69 39 preserved preserve VBN cord-019043-cqmqwl3i 69 40 trending trend VBG cord-019043-cqmqwl3i 69 41 [ [ -LRB- cord-019043-cqmqwl3i 69 42 2 2 CD cord-019043-cqmqwl3i 69 43 ] ] -RRB- cord-019043-cqmqwl3i 69 44 . . . cord-019043-cqmqwl3i 70 1 Additional additional JJ cord-019043-cqmqwl3i 70 2 static static JJ cord-019043-cqmqwl3i 70 3 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 70 4 measures measure NNS cord-019043-cqmqwl3i 70 5 , , , cord-019043-cqmqwl3i 70 6 such such JJ cord-019043-cqmqwl3i 70 7 as as IN cord-019043-cqmqwl3i 70 8 central central JJ cord-019043-cqmqwl3i 70 9 venous venous JJ cord-019043-cqmqwl3i 70 10 pressure pressure NN cord-019043-cqmqwl3i 70 11 ( ( -LRB- cord-019043-cqmqwl3i 70 12 CVP CVP NNP cord-019043-cqmqwl3i 70 13 ) ) -RRB- cord-019043-cqmqwl3i 70 14 and and CC cord-019043-cqmqwl3i 70 15 pulmonary pulmonary JJ cord-019043-cqmqwl3i 70 16 artery artery NN cord-019043-cqmqwl3i 70 17 occlusion occlusion NN cord-019043-cqmqwl3i 70 18 pressure pressure NN cord-019043-cqmqwl3i 70 19 ( ( -LRB- cord-019043-cqmqwl3i 70 20 PAOP PAOP NNP cord-019043-cqmqwl3i 70 21 ) ) -RRB- cord-019043-cqmqwl3i 70 22 , , , cord-019043-cqmqwl3i 70 23 have have VBP cord-019043-cqmqwl3i 70 24 focused focus VBN cord-019043-cqmqwl3i 70 25 on on IN cord-019043-cqmqwl3i 70 26 providing provide VBG cord-019043-cqmqwl3i 70 27 an an DT cord-019043-cqmqwl3i 70 28 estimate estimate NN cord-019043-cqmqwl3i 70 29 of of IN cord-019043-cqmqwl3i 70 30 left left JJ cord-019043-cqmqwl3i 70 31 ventricular ventricular JJ cord-019043-cqmqwl3i 70 32 preload preload NN cord-019043-cqmqwl3i 70 33 to to TO cord-019043-cqmqwl3i 70 34 guide guide VB cord-019043-cqmqwl3i 70 35 fluid fluid JJ cord-019043-cqmqwl3i 70 36 resuscitation resuscitation NN cord-019043-cqmqwl3i 70 37 . . . cord-019043-cqmqwl3i 71 1 The the DT cord-019043-cqmqwl3i 71 2 challenge challenge NN cord-019043-cqmqwl3i 71 3 with with IN cord-019043-cqmqwl3i 71 4 these these DT cord-019043-cqmqwl3i 71 5 fixed fix VBN cord-019043-cqmqwl3i 71 6 pressure pressure NN cord-019043-cqmqwl3i 71 7 - - HYPH cord-019043-cqmqwl3i 71 8 derived derive VBN cord-019043-cqmqwl3i 71 9 measures measure NNS cord-019043-cqmqwl3i 71 10 is be VBZ cord-019043-cqmqwl3i 71 11 their -PRON- PRP$ cord-019043-cqmqwl3i 71 12 lack lack NN cord-019043-cqmqwl3i 71 13 of of IN cord-019043-cqmqwl3i 71 14 predictability predictability NN cord-019043-cqmqwl3i 71 15 to to TO cord-019043-cqmqwl3i 71 16 determine determine VB cord-019043-cqmqwl3i 71 17 whether whether IN cord-019043-cqmqwl3i 71 18 a a DT cord-019043-cqmqwl3i 71 19 patient patient NN cord-019043-cqmqwl3i 71 20 will will MD cord-019043-cqmqwl3i 71 21 positively positively RB cord-019043-cqmqwl3i 71 22 response response NN cord-019043-cqmqwl3i 71 23 to to IN cord-019043-cqmqwl3i 71 24 a a DT cord-019043-cqmqwl3i 71 25 fluid fluid JJ cord-019043-cqmqwl3i 71 26 challenge challenge NN cord-019043-cqmqwl3i 71 27 ( ( -LRB- cord-019043-cqmqwl3i 71 28 i.e. i.e. FW cord-019043-cqmqwl3i 71 29 , , , cord-019043-cqmqwl3i 71 30 show show VB cord-019043-cqmqwl3i 71 31 improvement improvement NN cord-019043-cqmqwl3i 71 32 in in IN cord-019043-cqmqwl3i 71 33 cardiac cardiac JJ cord-019043-cqmqwl3i 71 34 output output NN cord-019043-cqmqwl3i 71 35 and and CC cord-019043-cqmqwl3i 71 36 performance performance NN cord-019043-cqmqwl3i 71 37 associated associate VBN cord-019043-cqmqwl3i 71 38 with with IN cord-019043-cqmqwl3i 71 39 a a DT cord-019043-cqmqwl3i 71 40 fluid fluid JJ cord-019043-cqmqwl3i 71 41 bolus bolus NN cord-019043-cqmqwl3i 71 42 ) ) -RRB- cord-019043-cqmqwl3i 71 43 . . . cord-019043-cqmqwl3i 72 1 These these DT cord-019043-cqmqwl3i 72 2 measures measure NNS cord-019043-cqmqwl3i 72 3 are be VBP cord-019043-cqmqwl3i 72 4 confounded confound VBN cord-019043-cqmqwl3i 72 5 by by IN cord-019043-cqmqwl3i 72 6 alterations alteration NNS cord-019043-cqmqwl3i 72 7 in in IN cord-019043-cqmqwl3i 72 8 ventricular ventricular JJ cord-019043-cqmqwl3i 72 9 wall wall NN cord-019043-cqmqwl3i 72 10 compliance compliance NN cord-019043-cqmqwl3i 72 11 ( ( -LRB- cord-019043-cqmqwl3i 72 12 i.e. i.e. FW cord-019043-cqmqwl3i 72 13 , , , cord-019043-cqmqwl3i 72 14 LVH LVH NNP cord-019043-cqmqwl3i 72 15 in in IN cord-019043-cqmqwl3i 72 16 ESRD ESRD NNP cord-019043-cqmqwl3i 72 17 ) ) -RRB- cord-019043-cqmqwl3i 72 18 . . . cord-019043-cqmqwl3i 73 1 Both both DT cord-019043-cqmqwl3i 73 2 CVP CVP NNP cord-019043-cqmqwl3i 73 3 and and CC cord-019043-cqmqwl3i 73 4 PAOP PAOP NNP cord-019043-cqmqwl3i 73 5 lack lack NN cord-019043-cqmqwl3i 73 6 precision precision NN cord-019043-cqmqwl3i 73 7 in in IN cord-019043-cqmqwl3i 73 8 individual individual JJ cord-019043-cqmqwl3i 73 9 patients patient NNS cord-019043-cqmqwl3i 73 10 and and CC cord-019043-cqmqwl3i 73 11 should should MD cord-019043-cqmqwl3i 73 12 not not RB cord-019043-cqmqwl3i 73 13 be be VB cord-019043-cqmqwl3i 73 14 used use VBN cord-019043-cqmqwl3i 73 15 in in IN cord-019043-cqmqwl3i 73 16 isolation isolation NN cord-019043-cqmqwl3i 73 17 to to TO cord-019043-cqmqwl3i 73 18 guide guide VB cord-019043-cqmqwl3i 73 19 resuscitation resuscitation NN cord-019043-cqmqwl3i 73 20 . . . cord-019043-cqmqwl3i 74 1 This this DT cord-019043-cqmqwl3i 74 2 may may MD cord-019043-cqmqwl3i 74 3 contribute contribute VB cord-019043-cqmqwl3i 74 4 to to IN cord-019043-cqmqwl3i 74 5 excessive excessive JJ cord-019043-cqmqwl3i 74 6 and and CC cord-019043-cqmqwl3i 74 7 inappropriate inappropriate JJ cord-019043-cqmqwl3i 74 8 fluid fluid JJ cord-019043-cqmqwl3i 74 9 prescription prescription NN cord-019043-cqmqwl3i 74 10 . . . cord-019043-cqmqwl3i 75 1 The the DT cord-019043-cqmqwl3i 75 2 central central JJ cord-019043-cqmqwl3i 75 3 venous venous JJ cord-019043-cqmqwl3i 75 4 oxygenation oxygenation NN cord-019043-cqmqwl3i 75 5 ( ( -LRB- cord-019043-cqmqwl3i 75 6 ScVO ScVO NNP cord-019043-cqmqwl3i 75 7 2 2 CD cord-019043-cqmqwl3i 75 8 ) ) -RRB- cord-019043-cqmqwl3i 75 9 is be VBZ cord-019043-cqmqwl3i 75 10 generally generally RB cord-019043-cqmqwl3i 75 11 accepted accept VBN cord-019043-cqmqwl3i 75 12 surrogate surrogate NN cord-019043-cqmqwl3i 75 13 for for IN cord-019043-cqmqwl3i 75 14 the the DT cord-019043-cqmqwl3i 75 15 venous venous JJ cord-019043-cqmqwl3i 75 16 oxygen oxygen NN cord-019043-cqmqwl3i 75 17 saturation saturation NN cord-019043-cqmqwl3i 75 18 ( ( -LRB- cord-019043-cqmqwl3i 75 19 S s NN cord-019043-cqmqwl3i 75 20 v v NN cord-019043-cqmqwl3i 75 21 O2 o2 NN cord-019043-cqmqwl3i 75 22 ) ) -RRB- cord-019043-cqmqwl3i 75 23 and and CC cord-019043-cqmqwl3i 75 24 reflects reflect VBZ cord-019043-cqmqwl3i 75 25 the the DT cord-019043-cqmqwl3i 75 26 adequacy adequacy NN cord-019043-cqmqwl3i 75 27 of of IN cord-019043-cqmqwl3i 75 28 global global JJ cord-019043-cqmqwl3i 75 29 cardiac cardiac JJ cord-019043-cqmqwl3i 75 30 output output NN cord-019043-cqmqwl3i 75 31 and and CC cord-019043-cqmqwl3i 75 32 oxygen oxygen NN cord-019043-cqmqwl3i 75 33 delivery delivery NN cord-019043-cqmqwl3i 75 34 . . . cord-019043-cqmqwl3i 76 1 Functional functional JJ cord-019043-cqmqwl3i 76 2 dynamic dynamic JJ cord-019043-cqmqwl3i 76 3 metrics metric NNS cord-019043-cqmqwl3i 76 4 that that WDT cord-019043-cqmqwl3i 76 5 utilize utilize VBP cord-019043-cqmqwl3i 76 6 the the DT cord-019043-cqmqwl3i 76 7 observed observed JJ cord-019043-cqmqwl3i 76 8 variability variability NN cord-019043-cqmqwl3i 76 9 in in IN cord-019043-cqmqwl3i 76 10 left left JJ cord-019043-cqmqwl3i 76 11 ventricular ventricular JJ cord-019043-cqmqwl3i 76 12 filling fill VBG cord-019043-cqmqwl3i 76 13 Neurologic neurologic JJ cord-019043-cqmqwl3i 76 14 examination examination NN cord-019043-cqmqwl3i 76 15 , , , cord-019043-cqmqwl3i 76 16 CSF csf NN cord-019043-cqmqwl3i 76 17 examination examination NN cord-019043-cqmqwl3i 76 18 , , , cord-019043-cqmqwl3i 76 19 brain brain NN cord-019043-cqmqwl3i 76 20 radiology radiology NN cord-019043-cqmqwl3i 76 21 ( ( -LRB- cord-019043-cqmqwl3i 76 22 CT CT NNP cord-019043-cqmqwl3i 76 23 , , , cord-019043-cqmqwl3i 76 24 MRI MRI NNP cord-019043-cqmqwl3i 76 25 , , , cord-019043-cqmqwl3i 76 26 angiography angiography NN cord-019043-cqmqwl3i 76 27 ) ) -RRB- cord-019043-cqmqwl3i 76 28 , , , cord-019043-cqmqwl3i 76 29 EEG EEG NNP cord-019043-cqmqwl3i 76 30 , , , cord-019043-cqmqwl3i 76 31 brain brain NN cord-019043-cqmqwl3i 76 32 damage damage NN cord-019043-cqmqwl3i 76 33 - - HYPH cord-019043-cqmqwl3i 76 34 specific specific JJ cord-019043-cqmqwl3i 76 35 biomarkers biomarker NNS cord-019043-cqmqwl3i 76 36 ( ( -LRB- cord-019043-cqmqwl3i 76 37 neuronspecific neuronspecific NNP cord-019043-cqmqwl3i 76 38 enolase enolase NNP cord-019043-cqmqwl3i 76 39 , , , cord-019043-cqmqwl3i 76 40 S100β S100β NNP cord-019043-cqmqwl3i 76 41 , , , cord-019043-cqmqwl3i 76 42 myelin myelin JJ cord-019043-cqmqwl3i 76 43 basic basic JJ cord-019043-cqmqwl3i 76 44 protein protein NN cord-019043-cqmqwl3i 76 45 ) ) -RRB- cord-019043-cqmqwl3i 76 46 , , , cord-019043-cqmqwl3i 76 47 invasive invasive JJ cord-019043-cqmqwl3i 76 48 ICP ICP NNP cord-019043-cqmqwl3i 76 49 monitoring monitoring NN cord-019043-cqmqwl3i 76 50 , , , cord-019043-cqmqwl3i 76 51 cerebral cerebral JJ cord-019043-cqmqwl3i 76 52 microdialysis microdialysis NN cord-019043-cqmqwl3i 76 53 Sedation Sedation NNP cord-019043-cqmqwl3i 76 54 , , , cord-019043-cqmqwl3i 76 55 antiepileptic antiepileptic JJ cord-019043-cqmqwl3i 76 56 therapy therapy NN cord-019043-cqmqwl3i 76 57 , , , cord-019043-cqmqwl3i 76 58 intracranial intracranial JJ cord-019043-cqmqwl3i 76 59 hypertension hypertension NN cord-019043-cqmqwl3i 76 60 management management NN cord-019043-cqmqwl3i 76 61 , , , cord-019043-cqmqwl3i 76 62 intraventricular intraventricular JJ cord-019043-cqmqwl3i 76 63 drain drain NN cord-019043-cqmqwl3i 76 64 Abbreviations abbreviation NNS cord-019043-cqmqwl3i 76 65 : : : cord-019043-cqmqwl3i 76 66 CO co NN cord-019043-cqmqwl3i 76 67 2 2 CD cord-019043-cqmqwl3i 76 68 carbon carbon NN cord-019043-cqmqwl3i 76 69 dioxide dioxide NN cord-019043-cqmqwl3i 76 70 , , , cord-019043-cqmqwl3i 76 71 CPAP CPAP NNP cord-019043-cqmqwl3i 76 72 continuous continuous JJ cord-019043-cqmqwl3i 76 73 positive positive JJ cord-019043-cqmqwl3i 76 74 airway airway NN cord-019043-cqmqwl3i 76 75 pressure pressure NN cord-019043-cqmqwl3i 76 76 , , , cord-019043-cqmqwl3i 76 77 BIPAP BIPAP NNP cord-019043-cqmqwl3i 76 78 bilevel bilevel JJ cord-019043-cqmqwl3i 76 79 positive positive JJ cord-019043-cqmqwl3i 76 80 airway airway NN cord-019043-cqmqwl3i 76 81 pressure pressure NN cord-019043-cqmqwl3i 76 82 , , , cord-019043-cqmqwl3i 76 83 NGAL NGAL NNP cord-019043-cqmqwl3i 76 84 neutrophil neutrophil NN cord-019043-cqmqwl3i 76 85 - - HYPH cord-019043-cqmqwl3i 76 86 associated associate VBN cord-019043-cqmqwl3i 76 87 lipocalin lipocalin NN cord-019043-cqmqwl3i 76 88 , , , cord-019043-cqmqwl3i 76 89 KIM-1 KIM-1 NNP cord-019043-cqmqwl3i 76 90 kidney kidney NN cord-019043-cqmqwl3i 76 91 injury injury NN cord-019043-cqmqwl3i 76 92 molecule-1 molecule-1 NN cord-019043-cqmqwl3i 76 93 , , , cord-019043-cqmqwl3i 76 94 IL-18 IL-18 NNP cord-019043-cqmqwl3i 76 95 interleukin-18 interleukin-18 NNP cord-019043-cqmqwl3i 76 96 , , , cord-019043-cqmqwl3i 76 97 FABP FABP NNP cord-019043-cqmqwl3i 76 98 fatty fatty JJ cord-019043-cqmqwl3i 76 99 acid acid NN cord-019043-cqmqwl3i 76 100 binding bind VBG cord-019043-cqmqwl3i 76 101 protein protein NN cord-019043-cqmqwl3i 76 102 , , , cord-019043-cqmqwl3i 76 103 MARS MARS NNP cord-019043-cqmqwl3i 76 104 molecular molecular JJ cord-019043-cqmqwl3i 76 105 adsorbent adsorbent NN cord-019043-cqmqwl3i 76 106 circulation circulation NN cord-019043-cqmqwl3i 76 107 system system NN cord-019043-cqmqwl3i 76 108 , , , cord-019043-cqmqwl3i 76 109 NAG NAG NNP cord-019043-cqmqwl3i 76 110 N N NNP cord-019043-cqmqwl3i 76 111 - - HYPH cord-019043-cqmqwl3i 76 112 acetyl acetyl NNP cord-019043-cqmqwl3i 76 113 - - HYPH cord-019043-cqmqwl3i 76 114 β β NN cord-019043-cqmqwl3i 76 115 - - HYPH cord-019043-cqmqwl3i 76 116 D D NNP cord-019043-cqmqwl3i 76 117 - - HYPH cord-019043-cqmqwl3i 76 118 glucosaminidase glucosaminidase NN cord-019043-cqmqwl3i 76 119 , , , cord-019043-cqmqwl3i 76 120 CRRT CRRT NNP cord-019043-cqmqwl3i 76 121 continuous continuous JJ cord-019043-cqmqwl3i 76 122 renal renal JJ cord-019043-cqmqwl3i 76 123 replacement replacement NN cord-019043-cqmqwl3i 76 124 therapy therapy NN cord-019043-cqmqwl3i 76 125 , , , cord-019043-cqmqwl3i 76 126 SLED SLED NNP cord-019043-cqmqwl3i 76 127 sustained sustain VBD cord-019043-cqmqwl3i 76 128 low low JJ cord-019043-cqmqwl3i 76 129 - - HYPH cord-019043-cqmqwl3i 76 130 efficiency efficiency NN cord-019043-cqmqwl3i 76 131 dialysis dialysis NN cord-019043-cqmqwl3i 76 132 , , , cord-019043-cqmqwl3i 76 133 IRRT IRRT NNP cord-019043-cqmqwl3i 76 134 intermittent intermittent JJ cord-019043-cqmqwl3i 76 135 renal renal JJ cord-019043-cqmqwl3i 76 136 replacement replacement NN cord-019043-cqmqwl3i 76 137 therapy therapy NN cord-019043-cqmqwl3i 76 138 , , , cord-019043-cqmqwl3i 76 139 ICP ICP NNP cord-019043-cqmqwl3i 76 140 intracranial intracranial JJ cord-019043-cqmqwl3i 76 141 pressure pressure NN cord-019043-cqmqwl3i 76 142 Mechanical mechanical JJ cord-019043-cqmqwl3i 76 143 ventilation ventilation NN cord-019043-cqmqwl3i 76 144 is be VBZ cord-019043-cqmqwl3i 76 145 a a DT cord-019043-cqmqwl3i 76 146 core core NN cord-019043-cqmqwl3i 76 147 life life NN cord-019043-cqmqwl3i 76 148 - - HYPH cord-019043-cqmqwl3i 76 149 sustaining sustain VBG cord-019043-cqmqwl3i 76 150 technology technology NN cord-019043-cqmqwl3i 76 151 that that WDT cord-019043-cqmqwl3i 76 152 largely largely RB cord-019043-cqmqwl3i 76 153 defined define VBD cord-019043-cqmqwl3i 76 154 the the DT cord-019043-cqmqwl3i 76 155 modern modern JJ cord-019043-cqmqwl3i 76 156 practice practice NN cord-019043-cqmqwl3i 76 157 of of IN cord-019043-cqmqwl3i 76 158 critical critical JJ cord-019043-cqmqwl3i 76 159 care care NN cord-019043-cqmqwl3i 76 160 . . . cord-019043-cqmqwl3i 77 1 Most most RBS cord-019043-cqmqwl3i 77 2 critically critically RB cord-019043-cqmqwl3i 77 3 ill ill JJ cord-019043-cqmqwl3i 77 4 patients patient NNS cord-019043-cqmqwl3i 77 5 require require VBP cord-019043-cqmqwl3i 77 6 mechanical mechanical JJ cord-019043-cqmqwl3i 77 7 ventilation ventilation NN cord-019043-cqmqwl3i 77 8 , , , cord-019043-cqmqwl3i 77 9 whether whether IN cord-019043-cqmqwl3i 77 10 for for IN cord-019043-cqmqwl3i 77 11 lung lung NN cord-019043-cqmqwl3i 77 12 - - HYPH cord-019043-cqmqwl3i 77 13 specific specific JJ cord-019043-cqmqwl3i 77 14 indications indication NNS cord-019043-cqmqwl3i 77 15 ( ( -LRB- cord-019043-cqmqwl3i 77 16 i.e. i.e. FW cord-019043-cqmqwl3i 77 17 , , , cord-019043-cqmqwl3i 77 18 acute acute JJ cord-019043-cqmqwl3i 77 19 lung lung NN cord-019043-cqmqwl3i 77 20 injury injury NN cord-019043-cqmqwl3i 77 21 ) ) -RRB- cord-019043-cqmqwl3i 77 22 , , , cord-019043-cqmqwl3i 77 23 systemic systemic JJ cord-019043-cqmqwl3i 77 24 indications indication NNS cord-019043-cqmqwl3i 77 25 ( ( -LRB- cord-019043-cqmqwl3i 77 26 i.e. i.e. FW cord-019043-cqmqwl3i 77 27 , , , cord-019043-cqmqwl3i 77 28 shock shock NN cord-019043-cqmqwl3i 77 29 ) ) -RRB- cord-019043-cqmqwl3i 77 30 , , , cord-019043-cqmqwl3i 77 31 or or CC cord-019043-cqmqwl3i 77 32 postoperative postoperative JJ cord-019043-cqmqwl3i 77 33 support support NN cord-019043-cqmqwl3i 77 34 . . . cord-019043-cqmqwl3i 78 1 A a DT cord-019043-cqmqwl3i 78 2 summary summary NN cord-019043-cqmqwl3i 78 3 of of IN cord-019043-cqmqwl3i 78 4 the the DT cord-019043-cqmqwl3i 78 5 most most RBS cord-019043-cqmqwl3i 78 6 common common JJ cord-019043-cqmqwl3i 78 7 modes mode NNS cord-019043-cqmqwl3i 78 8 of of IN cord-019043-cqmqwl3i 78 9 mechanical mechanical JJ cord-019043-cqmqwl3i 78 10 ventilation ventilation NN cord-019043-cqmqwl3i 78 11 provided provide VBN cord-019043-cqmqwl3i 78 12 in in IN cord-019043-cqmqwl3i 78 13 the the DT cord-019043-cqmqwl3i 78 14 context context NN cord-019043-cqmqwl3i 78 15 of of IN cord-019043-cqmqwl3i 78 16 critical critical JJ cord-019043-cqmqwl3i 78 17 illness illness NN cord-019043-cqmqwl3i 78 18 is be VBZ cord-019043-cqmqwl3i 78 19 shown show VBN cord-019043-cqmqwl3i 78 20 in in IN cord-019043-cqmqwl3i 78 21 Pulse Pulse NNP cord-019043-cqmqwl3i 78 22 pressure pressure NN cord-019043-cqmqwl3i 78 23 variation variation NN cord-019043-cqmqwl3i 78 24 ( ( -LRB- cord-019043-cqmqwl3i 78 25 PPV PPV NNP cord-019043-cqmqwl3i 78 26 ) ) -RRB- cord-019043-cqmqwl3i 78 27 : : : cord-019043-cqmqwl3i 79 1 Defined define VBN cord-019043-cqmqwl3i 79 2 as as IN cord-019043-cqmqwl3i 79 3 the the DT cord-019043-cqmqwl3i 79 4 maximum maximum JJ cord-019043-cqmqwl3i 79 5 pulse pulse NN cord-019043-cqmqwl3i 79 6 pressure pressure NN cord-019043-cqmqwl3i 79 7 minus minus IN cord-019043-cqmqwl3i 79 8 the the DT cord-019043-cqmqwl3i 79 9 minimum minimum JJ cord-019043-cqmqwl3i 79 10 pulse pulse NN cord-019043-cqmqwl3i 79 11 pressure pressure NN cord-019043-cqmqwl3i 79 12 , , , cord-019043-cqmqwl3i 79 13 divided divide VBN cord-019043-cqmqwl3i 79 14 by by IN cord-019043-cqmqwl3i 79 15 the the DT cord-019043-cqmqwl3i 79 16 average average NN cord-019043-cqmqwl3i 79 17 of of IN cord-019043-cqmqwl3i 79 18 these these DT cord-019043-cqmqwl3i 79 19 two two CD cord-019043-cqmqwl3i 79 20 pressures pressure NNS cord-019043-cqmqwl3i 79 21 over over IN cord-019043-cqmqwl3i 79 22 a a DT cord-019043-cqmqwl3i 79 23 mechanically mechanically RB cord-019043-cqmqwl3i 79 24 delivered deliver VBN cord-019043-cqmqwl3i 79 25 breath breath NN cord-019043-cqmqwl3i 79 26 . . . cord-019043-cqmqwl3i 80 1 PPV PPV NNP cord-019043-cqmqwl3i 80 2 is be VBZ cord-019043-cqmqwl3i 80 3 based base VBN cord-019043-cqmqwl3i 80 4 on on IN cord-019043-cqmqwl3i 80 5 the the DT cord-019043-cqmqwl3i 80 6 premise premise NN cord-019043-cqmqwl3i 80 7 of of IN cord-019043-cqmqwl3i 80 8 pulsus pulsus NNP cord-019043-cqmqwl3i 80 9 paradoxus paradoxus NNP cord-019043-cqmqwl3i 80 10 , , , cord-019043-cqmqwl3i 80 11 the the DT cord-019043-cqmqwl3i 80 12 changes change NNS cord-019043-cqmqwl3i 80 13 in in IN cord-019043-cqmqwl3i 80 14 arterial arterial JJ cord-019043-cqmqwl3i 80 15 pressure pressure NN cord-019043-cqmqwl3i 80 16 during during IN cord-019043-cqmqwl3i 80 17 inspiration inspiration NN cord-019043-cqmqwl3i 80 18 and and CC cord-019043-cqmqwl3i 80 19 expiration expiration NN cord-019043-cqmqwl3i 80 20 . . . cord-019043-cqmqwl3i 81 1 PPV PPV NNP cord-019043-cqmqwl3i 81 2 is be VBZ cord-019043-cqmqwl3i 81 3 not not RB cord-019043-cqmqwl3i 81 4 a a DT cord-019043-cqmqwl3i 81 5 true true JJ cord-019043-cqmqwl3i 81 6 measure measure NN cord-019043-cqmqwl3i 81 7 of of IN cord-019043-cqmqwl3i 81 8 preload preload NN cord-019043-cqmqwl3i 81 9 or or CC cord-019043-cqmqwl3i 81 10 volume volume NN cord-019043-cqmqwl3i 81 11 status status NN cord-019043-cqmqwl3i 81 12 , , , cord-019043-cqmqwl3i 81 13 but but CC cord-019043-cqmqwl3i 81 14 an an DT cord-019043-cqmqwl3i 81 15 indicator indicator NN cord-019043-cqmqwl3i 81 16 of of IN cord-019043-cqmqwl3i 81 17 the the DT cord-019043-cqmqwl3i 81 18 position position NN cord-019043-cqmqwl3i 81 19 of of IN cord-019043-cqmqwl3i 81 20 the the DT cord-019043-cqmqwl3i 81 21 Frank Frank NNP cord-019043-cqmqwl3i 81 22 - - HYPH cord-019043-cqmqwl3i 81 23 Starling Starling NNP cord-019043-cqmqwl3i 81 24 relationship relationship NN cord-019043-cqmqwl3i 81 25 curve curve NN cord-019043-cqmqwl3i 81 26 between between IN cord-019043-cqmqwl3i 81 27 stroke stroke NN cord-019043-cqmqwl3i 81 28 volume volume NN cord-019043-cqmqwl3i 81 29 and and CC cord-019043-cqmqwl3i 81 30 preload preload NN cord-019043-cqmqwl3i 81 31 to to TO cord-019043-cqmqwl3i 81 32 predict predict VB cord-019043-cqmqwl3i 81 33 fluid fluid JJ cord-019043-cqmqwl3i 81 34 responsiveness responsiveness NN cord-019043-cqmqwl3i 81 35 : : : cord-019043-cqmqwl3i 81 36 Stroke stroke NN cord-019043-cqmqwl3i 81 37 volume volume NN cord-019043-cqmqwl3i 81 38 variation variation NN cord-019043-cqmqwl3i 81 39 ( ( -LRB- cord-019043-cqmqwl3i 81 40 SVV SVV NNP cord-019043-cqmqwl3i 81 41 ) ) -RRB- cord-019043-cqmqwl3i 81 42 : : : cord-019043-cqmqwl3i 82 1 Defined define VBN cord-019043-cqmqwl3i 82 2 as as IN cord-019043-cqmqwl3i 82 3 the the DT cord-019043-cqmqwl3i 82 4 percentage percentage NN cord-019043-cqmqwl3i 82 5 of of IN cord-019043-cqmqwl3i 82 6 change change NN cord-019043-cqmqwl3i 82 7 between between IN cord-019043-cqmqwl3i 82 8 the the DT cord-019043-cqmqwl3i 82 9 maximum maximum JJ cord-019043-cqmqwl3i 82 10 and and CC cord-019043-cqmqwl3i 82 11 minimum minimum JJ cord-019043-cqmqwl3i 82 12 stroke stroke NN cord-019043-cqmqwl3i 82 13 volumes volume NNS cord-019043-cqmqwl3i 82 14 over over IN cord-019043-cqmqwl3i 82 15 a a DT cord-019043-cqmqwl3i 82 16 certain certain JJ cord-019043-cqmqwl3i 82 17 interval interval NN cord-019043-cqmqwl3i 82 18 . . . cord-019043-cqmqwl3i 83 1 Similar similar JJ cord-019043-cqmqwl3i 83 2 to to IN cord-019043-cqmqwl3i 83 3 PPV PPV NNP cord-019043-cqmqwl3i 83 4 , , , cord-019043-cqmqwl3i 83 5 SVV SVV NNP cord-019043-cqmqwl3i 83 6 is be VBZ cord-019043-cqmqwl3i 83 7 not not RB cord-019043-cqmqwl3i 83 8 a a DT cord-019043-cqmqwl3i 83 9 true true JJ cord-019043-cqmqwl3i 83 10 measure measure NN cord-019043-cqmqwl3i 83 11 of of IN cord-019043-cqmqwl3i 83 12 volume volume NN cord-019043-cqmqwl3i 83 13 status status NN cord-019043-cqmqwl3i 83 14 or or CC cord-019043-cqmqwl3i 83 15 preload preload NN cord-019043-cqmqwl3i 83 16 but but CC cord-019043-cqmqwl3i 83 17 rather rather RB cord-019043-cqmqwl3i 83 18 an an DT cord-019043-cqmqwl3i 83 19 assessment assessment NN cord-019043-cqmqwl3i 83 20 of of IN cord-019043-cqmqwl3i 83 21 response response NN cord-019043-cqmqwl3i 83 22 to to IN cord-019043-cqmqwl3i 83 23 fluid fluid JJ cord-019043-cqmqwl3i 83 24 resuscitation resuscitation NN cord-019043-cqmqwl3i 84 1 : : : cord-019043-cqmqwl3i 84 2 Abbreviations abbreviation NNS cord-019043-cqmqwl3i 84 3 : : : cord-019043-cqmqwl3i 85 1 VCV VCV NNP cord-019043-cqmqwl3i 85 2 volume volume NN cord-019043-cqmqwl3i 85 3 - - HYPH cord-019043-cqmqwl3i 85 4 controlled control VBN cord-019043-cqmqwl3i 85 5 ventilation ventilation NN cord-019043-cqmqwl3i 85 6 , , , cord-019043-cqmqwl3i 85 7 PCV PCV NNP cord-019043-cqmqwl3i 85 8 pressure pressure NN cord-019043-cqmqwl3i 85 9 - - HYPH cord-019043-cqmqwl3i 85 10 controlled control VBN cord-019043-cqmqwl3i 85 11 ventilation ventilation NN cord-019043-cqmqwl3i 85 12 , , , cord-019043-cqmqwl3i 85 13 PSV PSV NNP cord-019043-cqmqwl3i 85 14 pressure pressure NN cord-019043-cqmqwl3i 85 15 support support NN cord-019043-cqmqwl3i 85 16 ventilation ventilation NN cord-019043-cqmqwl3i 86 1 , , , cord-019043-cqmqwl3i 86 2 SIMV SIMV NNP cord-019043-cqmqwl3i 86 3 synchronized synchronize VBD cord-019043-cqmqwl3i 86 4 intermittent intermittent JJ cord-019043-cqmqwl3i 86 5 mandatory mandatory JJ cord-019043-cqmqwl3i 86 6 ventilation ventilation NN cord-019043-cqmqwl3i 86 7 , , , cord-019043-cqmqwl3i 86 8 Vt Vt NNP cord-019043-cqmqwl3i 86 9 tidal tidal JJ cord-019043-cqmqwl3i 86 10 volume volume NN cord-019043-cqmqwl3i 86 11 , , , cord-019043-cqmqwl3i 86 12 PEEP peep NN cord-019043-cqmqwl3i 86 13 positive positive JJ cord-019043-cqmqwl3i 86 14 end end NN cord-019043-cqmqwl3i 86 15 - - HYPH cord-019043-cqmqwl3i 86 16 expiratory expiratory NN cord-019043-cqmqwl3i 86 17 pressure pressure NN cord-019043-cqmqwl3i 86 18 , , , cord-019043-cqmqwl3i 86 19 VILI VILI NNP cord-019043-cqmqwl3i 86 20 ventilator ventilator NN cord-019043-cqmqwl3i 86 21 - - HYPH cord-019043-cqmqwl3i 86 22 induced induce VBN cord-019043-cqmqwl3i 86 23 lung lung NN cord-019043-cqmqwl3i 86 24 injury injury NN cord-019043-cqmqwl3i 86 25 , , , cord-019043-cqmqwl3i 86 26 Ti Ti NNP cord-019043-cqmqwl3i 86 27 inspiratory inspiratory JJ cord-019043-cqmqwl3i 86 28 time time NN cord-019043-cqmqwl3i 86 29 utilization utilization NN cord-019043-cqmqwl3i 86 30 of of IN cord-019043-cqmqwl3i 86 31 mechanical mechanical JJ cord-019043-cqmqwl3i 86 32 ventilation ventilation NN cord-019043-cqmqwl3i 86 33 for for IN cord-019043-cqmqwl3i 86 34 critically critically RB cord-019043-cqmqwl3i 86 35 ill ill JJ cord-019043-cqmqwl3i 86 36 patients patient NNS cord-019043-cqmqwl3i 86 37 in in IN cord-019043-cqmqwl3i 86 38 recent recent JJ cord-019043-cqmqwl3i 86 39 years year NNS cord-019043-cqmqwl3i 86 40 . . . cord-019043-cqmqwl3i 87 1 These these DT cord-019043-cqmqwl3i 87 2 patients patient NNS cord-019043-cqmqwl3i 87 3 are be VBP cord-019043-cqmqwl3i 87 4 generally generally RB cord-019043-cqmqwl3i 87 5 burdened burden VBN cord-019043-cqmqwl3i 87 6 with with IN cord-019043-cqmqwl3i 87 7 a a DT cord-019043-cqmqwl3i 87 8 high high JJ cord-019043-cqmqwl3i 87 9 prevalence prevalence NN cord-019043-cqmqwl3i 87 10 of of IN cord-019043-cqmqwl3i 87 11 comorbid comorbid NN cord-019043-cqmqwl3i 87 12 disease disease NN cord-019043-cqmqwl3i 87 13 , , , cord-019043-cqmqwl3i 87 14 in in IN cord-019043-cqmqwl3i 87 15 particular particular JJ cord-019043-cqmqwl3i 87 16 CKD CKD NNP cord-019043-cqmqwl3i 87 17 , , , cord-019043-cqmqwl3i 87 18 representing represent VBG cord-019043-cqmqwl3i 87 19 up up IN cord-019043-cqmqwl3i 87 20 to to IN cord-019043-cqmqwl3i 87 21 one one CD cord-019043-cqmqwl3i 87 22 quarter quarter NN cord-019043-cqmqwl3i 87 23 of of IN cord-019043-cqmqwl3i 87 24 all all DT cord-019043-cqmqwl3i 87 25 mechanically mechanically RB cord-019043-cqmqwl3i 87 26 ventilated ventilate VBN cord-019043-cqmqwl3i 87 27 patients patient NNS cord-019043-cqmqwl3i 87 28 . . . cord-019043-cqmqwl3i 88 1 Kidney kidney NN cord-019043-cqmqwl3i 88 2 disease disease NN cord-019043-cqmqwl3i 88 3 , , , cord-019043-cqmqwl3i 88 4 both both CC cord-019043-cqmqwl3i 88 5 acute acute JJ cord-019043-cqmqwl3i 88 6 and and CC cord-019043-cqmqwl3i 88 7 chronic chronic JJ cord-019043-cqmqwl3i 88 8 , , , cord-019043-cqmqwl3i 88 9 can can MD cord-019043-cqmqwl3i 88 10 present present VB cord-019043-cqmqwl3i 88 11 unique unique JJ cord-019043-cqmqwl3i 88 12 challenges challenge NNS cord-019043-cqmqwl3i 88 13 with with IN cord-019043-cqmqwl3i 88 14 respect respect NN cord-019043-cqmqwl3i 88 15 to to IN cord-019043-cqmqwl3i 88 16 respiratory respiratory JJ cord-019043-cqmqwl3i 88 17 physiology physiology NN cord-019043-cqmqwl3i 88 18 , , , cord-019043-cqmqwl3i 88 19 lung lung NN cord-019043-cqmqwl3i 88 20 - - HYPH cord-019043-cqmqwl3i 88 21 kidney kidney NN cord-019043-cqmqwl3i 88 22 interaction interaction NN cord-019043-cqmqwl3i 88 23 , , , cord-019043-cqmqwl3i 88 24 and and CC cord-019043-cqmqwl3i 88 25 mechanical mechanical JJ cord-019043-cqmqwl3i 88 26 ventilation ventilation NN cord-019043-cqmqwl3i 88 27 support support NN cord-019043-cqmqwl3i 88 28 [ [ -LRB- cord-019043-cqmqwl3i 88 29 3 3 CD cord-019043-cqmqwl3i 88 30 ] ] -RRB- cord-019043-cqmqwl3i 88 31 . . . cord-019043-cqmqwl3i 89 1 First first RB cord-019043-cqmqwl3i 89 2 , , , cord-019043-cqmqwl3i 89 3 CKD/ ckd/ JJ cord-019043-cqmqwl3i 89 4 ESRD ESRD NNP cord-019043-cqmqwl3i 89 5 patients patient NNS cord-019043-cqmqwl3i 89 6 often often RB cord-019043-cqmqwl3i 89 7 have have VBP cord-019043-cqmqwl3i 89 8 high high JJ cord-019043-cqmqwl3i 89 9 prevalence prevalence NN cord-019043-cqmqwl3i 89 10 of of IN cord-019043-cqmqwl3i 89 11 comorbid comorbid JJ cord-019043-cqmqwl3i 89 12 respiratory respiratory JJ cord-019043-cqmqwl3i 89 13 illness illness NN cord-019043-cqmqwl3i 89 14 such such JJ cord-019043-cqmqwl3i 89 15 as as IN cord-019043-cqmqwl3i 89 16 restrictive restrictive JJ cord-019043-cqmqwl3i 89 17 or or CC cord-019043-cqmqwl3i 89 18 obstructive obstructive JJ cord-019043-cqmqwl3i 89 19 defects defect NNS cord-019043-cqmqwl3i 89 20 , , , cord-019043-cqmqwl3i 89 21 pleural pleural JJ cord-019043-cqmqwl3i 89 22 disease disease NN cord-019043-cqmqwl3i 89 23 , , , cord-019043-cqmqwl3i 89 24 pulmonary pulmonary JJ cord-019043-cqmqwl3i 89 25 calcification calcification NN cord-019043-cqmqwl3i 89 26 , , , cord-019043-cqmqwl3i 89 27 sleep sleep NN cord-019043-cqmqwl3i 89 28 apnea apnea NN cord-019043-cqmqwl3i 89 29 , , , cord-019043-cqmqwl3i 89 30 or or CC cord-019043-cqmqwl3i 89 31 dialysis dialysis NN cord-019043-cqmqwl3i 89 32 - - HYPH cord-019043-cqmqwl3i 89 33 associated associate VBN cord-019043-cqmqwl3i 89 34 hypoxemia hypoxemia NN cord-019043-cqmqwl3i 89 35 . . . cord-019043-cqmqwl3i 90 1 Patients patient NNS cord-019043-cqmqwl3i 90 2 receiving receive VBG cord-019043-cqmqwl3i 90 3 PD PD NNP cord-019043-cqmqwl3i 90 4 have have VBP cord-019043-cqmqwl3i 90 5 chronically chronically RB cord-019043-cqmqwl3i 90 6 elevated elevate VBN cord-019043-cqmqwl3i 90 7 intra intra JJ cord-019043-cqmqwl3i 90 8 - - JJ cord-019043-cqmqwl3i 90 9 abdominal abdominal JJ cord-019043-cqmqwl3i 90 10 pressure pressure NN cord-019043-cqmqwl3i 90 11 and and CC cord-019043-cqmqwl3i 90 12 diminished diminish VBD cord-019043-cqmqwl3i 90 13 functional functional JJ cord-019043-cqmqwl3i 90 14 residual residual JJ cord-019043-cqmqwl3i 90 15 capacity capacity NN cord-019043-cqmqwl3i 90 16 . . . cord-019043-cqmqwl3i 91 1 These these DT cord-019043-cqmqwl3i 91 2 factors factor NNS cord-019043-cqmqwl3i 91 3 predispose predispose VBP cord-019043-cqmqwl3i 91 4 to to IN cord-019043-cqmqwl3i 91 5 limited limited JJ cord-019043-cqmqwl3i 91 6 pulmonary pulmonary JJ cord-019043-cqmqwl3i 91 7 reserve reserve NN cord-019043-cqmqwl3i 91 8 . . . cord-019043-cqmqwl3i 92 1 Second second RB cord-019043-cqmqwl3i 92 2 , , , cord-019043-cqmqwl3i 92 3 CKD CKD NNP cord-019043-cqmqwl3i 92 4 / / SYM cord-019043-cqmqwl3i 92 5 ESRD ESRD NNP cord-019043-cqmqwl3i 92 6 patients patient NNS cord-019043-cqmqwl3i 92 7 often often RB cord-019043-cqmqwl3i 92 8 have have VBP cord-019043-cqmqwl3i 92 9 diminished diminish VBN cord-019043-cqmqwl3i 92 10 cardiac cardiac JJ cord-019043-cqmqwl3i 92 11 reserve reserve NN cord-019043-cqmqwl3i 92 12 and and CC cord-019043-cqmqwl3i 92 13 all all DT cord-019043-cqmqwl3i 92 14 have have VBP cord-019043-cqmqwl3i 92 15 compromised compromise VBN cord-019043-cqmqwl3i 92 16 capacity capacity NN cord-019043-cqmqwl3i 92 17 to to TO cord-019043-cqmqwl3i 92 18 excrete excrete VB cord-019043-cqmqwl3i 92 19 solute solute NN cord-019043-cqmqwl3i 92 20 and and CC cord-019043-cqmqwl3i 92 21 water water NN cord-019043-cqmqwl3i 92 22 . . . cord-019043-cqmqwl3i 93 1 Acute acute JJ cord-019043-cqmqwl3i 93 2 cardiac cardiac JJ cord-019043-cqmqwl3i 93 3 events event NNS cord-019043-cqmqwl3i 94 1 and/or and/or CC cord-019043-cqmqwl3i 94 2 fluid fluid JJ cord-019043-cqmqwl3i 94 3 accumulation accumulation NN cord-019043-cqmqwl3i 94 4 ( ( -LRB- cord-019043-cqmqwl3i 94 5 i.e. i.e. FW cord-019043-cqmqwl3i 94 6 , , , cord-019043-cqmqwl3i 94 7 noncompliance noncompliance NN cord-019043-cqmqwl3i 94 8 with with IN cord-019043-cqmqwl3i 94 9 diet diet NN cord-019043-cqmqwl3i 94 10 , , , cord-019043-cqmqwl3i 94 11 inappropriate inappropriate JJ cord-019043-cqmqwl3i 94 12 dry dry JJ cord-019043-cqmqwl3i 94 13 weight weight NN cord-019043-cqmqwl3i 94 14 prescription prescription NN cord-019043-cqmqwl3i 94 15 , , , cord-019043-cqmqwl3i 94 16 missed miss VBN cord-019043-cqmqwl3i 94 17 dialysis dialysis NN cord-019043-cqmqwl3i 94 18 ) ) -RRB- cord-019043-cqmqwl3i 94 19 can can MD cord-019043-cqmqwl3i 94 20 predispose predispose VB cord-019043-cqmqwl3i 94 21 to to TO cord-019043-cqmqwl3i 94 22 acute acute JJ cord-019043-cqmqwl3i 94 23 cardiorenal cardiorenal JJ cord-019043-cqmqwl3i 94 24 syndrome syndrome NN cord-019043-cqmqwl3i 94 25 and and CC cord-019043-cqmqwl3i 94 26 pulmonary pulmonary JJ cord-019043-cqmqwl3i 94 27 edema edema NN cord-019043-cqmqwl3i 94 28 . . . cord-019043-cqmqwl3i 95 1 Third third RB cord-019043-cqmqwl3i 95 2 , , , cord-019043-cqmqwl3i 95 3 the the DT cord-019043-cqmqwl3i 95 4 development development NN cord-019043-cqmqwl3i 95 5 of of IN cord-019043-cqmqwl3i 95 6 acute acute JJ cord-019043-cqmqwl3i 95 7 injury injury NN cord-019043-cqmqwl3i 95 8 to to IN cord-019043-cqmqwl3i 95 9 the the DT cord-019043-cqmqwl3i 95 10 kidney kidney NN cord-019043-cqmqwl3i 95 11 can can MD cord-019043-cqmqwl3i 95 12 induce induce VB cord-019043-cqmqwl3i 95 13 a a DT cord-019043-cqmqwl3i 95 14 systemic systemic JJ cord-019043-cqmqwl3i 95 15 inflammatory inflammatory JJ cord-019043-cqmqwl3i 95 16 response response NN cord-019043-cqmqwl3i 95 17 with with IN cord-019043-cqmqwl3i 95 18 distant distant JJ cord-019043-cqmqwl3i 95 19 pathophysiologic pathophysiologic JJ cord-019043-cqmqwl3i 95 20 effects effect NNS cord-019043-cqmqwl3i 95 21 in in IN cord-019043-cqmqwl3i 95 22 the the DT cord-019043-cqmqwl3i 95 23 lung lung NN cord-019043-cqmqwl3i 95 24 ( ( -LRB- cord-019043-cqmqwl3i 95 25 i.e. i.e. FW cord-019043-cqmqwl3i 95 26 , , , cord-019043-cqmqwl3i 95 27 alterations alteration NNS cord-019043-cqmqwl3i 95 28 in in IN cord-019043-cqmqwl3i 95 29 alveolar alveolar JJ cord-019043-cqmqwl3i 95 30 permeability permeability NN cord-019043-cqmqwl3i 95 31 and and CC cord-019043-cqmqwl3i 95 32 aquaporin aquaporin NN cord-019043-cqmqwl3i 95 33 expression expression NN cord-019043-cqmqwl3i 95 34 ) ) -RRB- cord-019043-cqmqwl3i 95 35 . . . cord-019043-cqmqwl3i 96 1 Fourth fourth RB cord-019043-cqmqwl3i 96 2 , , , cord-019043-cqmqwl3i 96 3 the the DT cord-019043-cqmqwl3i 96 4 positive positive JJ cord-019043-cqmqwl3i 96 5 pressure pressure NN cord-019043-cqmqwl3i 96 6 applied apply VBN cord-019043-cqmqwl3i 96 7 during during IN cord-019043-cqmqwl3i 96 8 mechanical mechanical JJ cord-019043-cqmqwl3i 96 9 ventilation ventilation NN cord-019043-cqmqwl3i 96 10 acts act NNS cord-019043-cqmqwl3i 96 11 to to TO cord-019043-cqmqwl3i 96 12 increase increase VB cord-019043-cqmqwl3i 96 13 intrathoracic intrathoracic JJ cord-019043-cqmqwl3i 96 14 , , , cord-019043-cqmqwl3i 96 15 intrapleural intrapleural JJ cord-019043-cqmqwl3i 96 16 , , , cord-019043-cqmqwl3i 96 17 and and CC cord-019043-cqmqwl3i 96 18 intra intra JJ cord-019043-cqmqwl3i 96 19 - - JJ cord-019043-cqmqwl3i 96 20 abdominal abdominal JJ cord-019043-cqmqwl3i 96 21 pressures pressure NNS cord-019043-cqmqwl3i 96 22 both both CC cord-019043-cqmqwl3i 96 23 during during IN cord-019043-cqmqwl3i 96 24 inspiration inspiration NN cord-019043-cqmqwl3i 96 25 and and CC cord-019043-cqmqwl3i 96 26 for for IN cord-019043-cqmqwl3i 96 27 the the DT cord-019043-cqmqwl3i 96 28 duration duration NN cord-019043-cqmqwl3i 96 29 of of IN cord-019043-cqmqwl3i 96 30 the the DT cord-019043-cqmqwl3i 96 31 respiratory respiratory JJ cord-019043-cqmqwl3i 96 32 cycle cycle NN cord-019043-cqmqwl3i 96 33 ( ( -LRB- cord-019043-cqmqwl3i 96 34 i.e. i.e. FW cord-019043-cqmqwl3i 96 35 , , , cord-019043-cqmqwl3i 96 36 PEEP peep NN cord-019043-cqmqwl3i 96 37 ) ) -RRB- cord-019043-cqmqwl3i 96 38 with with IN cord-019043-cqmqwl3i 96 39 the the DT cord-019043-cqmqwl3i 96 40 aim aim NN cord-019043-cqmqwl3i 96 41 to to TO cord-019043-cqmqwl3i 96 42 improve improve VB cord-019043-cqmqwl3i 96 43 and and CC cord-019043-cqmqwl3i 96 44 maintain maintain VB cord-019043-cqmqwl3i 96 45 adequate adequate JJ cord-019043-cqmqwl3i 96 46 gas gas NN cord-019043-cqmqwl3i 96 47 exchange exchange NN cord-019043-cqmqwl3i 96 48 . . . cord-019043-cqmqwl3i 97 1 This this DT cord-019043-cqmqwl3i 97 2 can can MD cord-019043-cqmqwl3i 97 3 stimulate stimulate VB cord-019043-cqmqwl3i 97 4 an an DT cord-019043-cqmqwl3i 97 5 array array NN cord-019043-cqmqwl3i 97 6 of of IN cord-019043-cqmqwl3i 97 7 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 97 8 , , , cord-019043-cqmqwl3i 97 9 neural neural JJ cord-019043-cqmqwl3i 97 10 , , , cord-019043-cqmqwl3i 97 11 and and CC cord-019043-cqmqwl3i 97 12 hormonal hormonal JJ cord-019043-cqmqwl3i 97 13 responses response NNS cord-019043-cqmqwl3i 97 14 that that WDT cord-019043-cqmqwl3i 97 15 can can MD cord-019043-cqmqwl3i 97 16 negatively negatively RB cord-019043-cqmqwl3i 97 17 impact impact VB cord-019043-cqmqwl3i 97 18 kidney kidney NN cord-019043-cqmqwl3i 97 19 perfusion perfusion NN cord-019043-cqmqwl3i 97 20 and and CC cord-019043-cqmqwl3i 97 21 further far RBR cord-019043-cqmqwl3i 97 22 inhibit inhibit VB cord-019043-cqmqwl3i 97 23 excretory excretory JJ cord-019043-cqmqwl3i 97 24 function function NN cord-019043-cqmqwl3i 97 25 . . . cord-019043-cqmqwl3i 98 1 This this DT cord-019043-cqmqwl3i 98 2 is be VBZ cord-019043-cqmqwl3i 98 3 observed observe VBN cord-019043-cqmqwl3i 98 4 as as IN cord-019043-cqmqwl3i 98 5 immediate immediate JJ cord-019043-cqmqwl3i 98 6 and and CC cord-019043-cqmqwl3i 98 7 reversible reversible JJ cord-019043-cqmqwl3i 98 8 declines decline NNS cord-019043-cqmqwl3i 98 9 in in IN cord-019043-cqmqwl3i 98 10 urine urine NN cord-019043-cqmqwl3i 98 11 output output NN cord-019043-cqmqwl3i 98 12 and and CC cord-019043-cqmqwl3i 98 13 fluid fluid JJ cord-019043-cqmqwl3i 98 14 retention retention NN cord-019043-cqmqwl3i 98 15 , , , cord-019043-cqmqwl3i 98 16 contributing contribute VBG cord-019043-cqmqwl3i 98 17 to to IN cord-019043-cqmqwl3i 98 18 worsening worsen VBG cord-019043-cqmqwl3i 98 19 fluid fluid JJ cord-019043-cqmqwl3i 98 20 accumulation accumulation NN cord-019043-cqmqwl3i 98 21 . . . cord-019043-cqmqwl3i 99 1 Finally finally RB cord-019043-cqmqwl3i 99 2 , , , cord-019043-cqmqwl3i 99 3 mechanical mechanical JJ cord-019043-cqmqwl3i 99 4 ventilation ventilation NN cord-019043-cqmqwl3i 99 5 may may MD cord-019043-cqmqwl3i 99 6 provoke provoke VB cord-019043-cqmqwl3i 99 7 ventilator ventilator NN cord-019043-cqmqwl3i 99 8 - - HYPH cord-019043-cqmqwl3i 99 9 induced induce VBN cord-019043-cqmqwl3i 99 10 lung lung NN cord-019043-cqmqwl3i 99 11 injury injury NN cord-019043-cqmqwl3i 99 12 ( ( -LRB- cord-019043-cqmqwl3i 99 13 VILI VILI NNP cord-019043-cqmqwl3i 99 14 ) ) -RRB- cord-019043-cqmqwl3i 99 15 leading lead VBG cord-019043-cqmqwl3i 99 16 to to IN cord-019043-cqmqwl3i 99 17 an an DT cord-019043-cqmqwl3i 99 18 exacerbating exacerbate VBG cord-019043-cqmqwl3i 99 19 cascade cascade NN cord-019043-cqmqwl3i 99 20 of of IN cord-019043-cqmqwl3i 99 21 systemic systemic JJ cord-019043-cqmqwl3i 99 22 inflammation inflammation NN cord-019043-cqmqwl3i 99 23 that that WDT cord-019043-cqmqwl3i 99 24 may may MD cord-019043-cqmqwl3i 99 25 have have VB cord-019043-cqmqwl3i 99 26 distant distant JJ cord-019043-cqmqwl3i 99 27 injurious injurious JJ cord-019043-cqmqwl3i 99 28 effects effect NNS cord-019043-cqmqwl3i 99 29 on on IN cord-019043-cqmqwl3i 99 30 the the DT cord-019043-cqmqwl3i 99 31 kidney kidney NN cord-019043-cqmqwl3i 99 32 [ [ -LRB- cord-019043-cqmqwl3i 99 33 3 3 CD cord-019043-cqmqwl3i 99 34 ] ] -RRB- cord-019043-cqmqwl3i 99 35 . . . cord-019043-cqmqwl3i 100 1 Data datum NNS cord-019043-cqmqwl3i 100 2 have have VBP cord-019043-cqmqwl3i 100 3 also also RB cord-019043-cqmqwl3i 100 4 shown show VBN cord-019043-cqmqwl3i 100 5 the the DT cord-019043-cqmqwl3i 100 6 development development NN cord-019043-cqmqwl3i 100 7 of of IN cord-019043-cqmqwl3i 100 8 AKI AKI NNP cord-019043-cqmqwl3i 100 9 may may MD cord-019043-cqmqwl3i 100 10 delay delay VB cord-019043-cqmqwl3i 100 11 weaning wean VBG cord-019043-cqmqwl3i 100 12 from from IN cord-019043-cqmqwl3i 100 13 mechanical mechanical JJ cord-019043-cqmqwl3i 100 14 ventilation ventilation NN cord-019043-cqmqwl3i 100 15 [ [ -LRB- cord-019043-cqmqwl3i 100 16 4 4 CD cord-019043-cqmqwl3i 100 17 ] ] -RRB- cord-019043-cqmqwl3i 100 18 . . . cord-019043-cqmqwl3i 101 1 This this DT cord-019043-cqmqwl3i 101 2 is be VBZ cord-019043-cqmqwl3i 101 3 likely likely RB cord-019043-cqmqwl3i 101 4 multifactorial multifactorial JJ cord-019043-cqmqwl3i 101 5 and and CC cord-019043-cqmqwl3i 101 6 related relate VBN cord-019043-cqmqwl3i 101 7 to to IN cord-019043-cqmqwl3i 101 8 greater great JJR cord-019043-cqmqwl3i 101 9 difficulties difficulty NNS cord-019043-cqmqwl3i 101 10 with with IN cord-019043-cqmqwl3i 101 11 volume volume NN cord-019043-cqmqwl3i 101 12 and and CC cord-019043-cqmqwl3i 101 13 acid acid NN cord-019043-cqmqwl3i 101 14 - - HYPH cord-019043-cqmqwl3i 101 15 base base NN cord-019043-cqmqwl3i 101 16 homeostasis homeostasis NN cord-019043-cqmqwl3i 101 17 in in IN cord-019043-cqmqwl3i 101 18 AKI AKI NNP cord-019043-cqmqwl3i 101 19 . . . cord-019043-cqmqwl3i 102 1 By by IN cord-019043-cqmqwl3i 102 2 extension extension NN cord-019043-cqmqwl3i 102 3 , , , cord-019043-cqmqwl3i 102 4 CKD CKD NNP cord-019043-cqmqwl3i 102 5 / / SYM cord-019043-cqmqwl3i 102 6 ESRD ESRD NNP cord-019043-cqmqwl3i 102 7 patients patient NNS cord-019043-cqmqwl3i 102 8 are be VBP cord-019043-cqmqwl3i 102 9 similarly similarly RB cord-019043-cqmqwl3i 102 10 likely likely JJ cord-019043-cqmqwl3i 102 11 to to TO cord-019043-cqmqwl3i 102 12 encounter encounter VB cord-019043-cqmqwl3i 102 13 prolonged prolong VBN cord-019043-cqmqwl3i 102 14 weaning weaning NN cord-019043-cqmqwl3i 102 15 from from IN cord-019043-cqmqwl3i 102 16 mechanical mechanical JJ cord-019043-cqmqwl3i 102 17 ventilation ventilation NN cord-019043-cqmqwl3i 102 18 . . . cord-019043-cqmqwl3i 103 1 The the DT cord-019043-cqmqwl3i 103 2 most most RBS cord-019043-cqmqwl3i 103 3 severe severe JJ cord-019043-cqmqwl3i 103 4 form form NN cord-019043-cqmqwl3i 103 5 of of IN cord-019043-cqmqwl3i 103 6 respiratory respiratory JJ cord-019043-cqmqwl3i 103 7 failure failure NN cord-019043-cqmqwl3i 103 8 is be VBZ cord-019043-cqmqwl3i 103 9 acute acute JJ cord-019043-cqmqwl3i 103 10 respiratory respiratory JJ cord-019043-cqmqwl3i 103 11 distress distress NN cord-019043-cqmqwl3i 103 12 syndrome syndrome NN cord-019043-cqmqwl3i 103 13 ( ( -LRB- cord-019043-cqmqwl3i 103 14 ARDS ARDS NNP cord-019043-cqmqwl3i 103 15 ) ) -RRB- cord-019043-cqmqwl3i 103 16 , , , cord-019043-cqmqwl3i 103 17 defined define VBN cord-019043-cqmqwl3i 103 18 as as IN cord-019043-cqmqwl3i 103 19 rapid rapid JJ cord-019043-cqmqwl3i 103 20 - - HYPH cord-019043-cqmqwl3i 103 21 onset onset NN cord-019043-cqmqwl3i 103 22 ( ( -LRB- cord-019043-cqmqwl3i 103 23 1 1 CD cord-019043-cqmqwl3i 103 24 week week NN cord-019043-cqmqwl3i 103 25 ) ) -RRB- cord-019043-cqmqwl3i 103 26 respiratory respiratory JJ cord-019043-cqmqwl3i 103 27 symptoms symptom NNS cord-019043-cqmqwl3i 103 28 and and CC cord-019043-cqmqwl3i 103 29 hypoxemia hypoxemia NN cord-019043-cqmqwl3i 103 30 associated associate VBN cord-019043-cqmqwl3i 103 31 with with IN cord-019043-cqmqwl3i 103 32 bilateral bilateral JJ cord-019043-cqmqwl3i 103 33 opacities opacity NNS cord-019043-cqmqwl3i 103 34 resulting result VBG cord-019043-cqmqwl3i 103 35 in in IN cord-019043-cqmqwl3i 103 36 respiratory respiratory JJ cord-019043-cqmqwl3i 103 37 failure failure NN cord-019043-cqmqwl3i 103 38 not not RB cord-019043-cqmqwl3i 103 39 fully fully RB cord-019043-cqmqwl3i 103 40 explained explain VBN cord-019043-cqmqwl3i 103 41 by by IN cord-019043-cqmqwl3i 103 42 cardiac cardiac JJ cord-019043-cqmqwl3i 103 43 failure failure NN cord-019043-cqmqwl3i 103 44 or or CC cord-019043-cqmqwl3i 103 45 fluid fluid JJ cord-019043-cqmqwl3i 103 46 overload overload NN cord-019043-cqmqwl3i 103 47 . . . cord-019043-cqmqwl3i 104 1 The the DT cord-019043-cqmqwl3i 104 2 incidence incidence NN cord-019043-cqmqwl3i 104 3 of of IN cord-019043-cqmqwl3i 104 4 milder mild JJR cord-019043-cqmqwl3i 104 5 forms form NNS cord-019043-cqmqwl3i 104 6 of of IN cord-019043-cqmqwl3i 104 7 ARDS ARDS NNP cord-019043-cqmqwl3i 104 8 is be VBZ cord-019043-cqmqwl3i 104 9 78.9/100,000 78.9/100,000 CD cord-019043-cqmqwl3i 104 10 person person NN cord-019043-cqmqwl3i 104 11 - - HYPH cord-019043-cqmqwl3i 104 12 years year NNS cord-019043-cqmqwl3i 104 13 while while IN cord-019043-cqmqwl3i 104 14 more more RBR cord-019043-cqmqwl3i 104 15 severe severe JJ cord-019043-cqmqwl3i 104 16 ARDS ARDS NNP cord-019043-cqmqwl3i 104 17 occurs occur VBZ cord-019043-cqmqwl3i 104 18 at at IN cord-019043-cqmqwl3i 104 19 a a DT cord-019043-cqmqwl3i 104 20 rate rate NN cord-019043-cqmqwl3i 104 21 of of IN cord-019043-cqmqwl3i 104 22 58.7/100,000 58.7/100,000 CD cord-019043-cqmqwl3i 104 23 personyears personyear NNS cord-019043-cqmqwl3i 104 24 . . . cord-019043-cqmqwl3i 105 1 The the DT cord-019043-cqmqwl3i 105 2 most most RBS cord-019043-cqmqwl3i 105 3 common common JJ cord-019043-cqmqwl3i 105 4 predisposing predisposing NN cord-019043-cqmqwl3i 105 5 factor factor NN cord-019043-cqmqwl3i 105 6 is be VBZ cord-019043-cqmqwl3i 105 7 pulmonary pulmonary JJ cord-019043-cqmqwl3i 105 8 and and CC cord-019043-cqmqwl3i 105 9 non non JJ cord-019043-cqmqwl3i 105 10 - - JJ cord-019043-cqmqwl3i 105 11 pulmonary pulmonary JJ cord-019043-cqmqwl3i 105 12 sepsis sepsis NN cord-019043-cqmqwl3i 105 13 . . . cord-019043-cqmqwl3i 106 1 The the DT cord-019043-cqmqwl3i 106 2 mortality mortality NN cord-019043-cqmqwl3i 106 3 remains remain VBZ cord-019043-cqmqwl3i 106 4 significant significant JJ cord-019043-cqmqwl3i 106 5 , , , cord-019043-cqmqwl3i 106 6 in in IN cord-019043-cqmqwl3i 106 7 the the DT cord-019043-cqmqwl3i 106 8 range range NN cord-019043-cqmqwl3i 106 9 of of IN cord-019043-cqmqwl3i 106 10 35 35 CD cord-019043-cqmqwl3i 106 11 - - SYM cord-019043-cqmqwl3i 106 12 40 40 CD cord-019043-cqmqwl3i 106 13 % % NN cord-019043-cqmqwl3i 106 14 , , , cord-019043-cqmqwl3i 106 15 and and CC cord-019043-cqmqwl3i 106 16 long long JJ cord-019043-cqmqwl3i 106 17 - - HYPH cord-019043-cqmqwl3i 106 18 term term NN cord-019043-cqmqwl3i 106 19 morbidity morbidity NN cord-019043-cqmqwl3i 106 20 among among IN cord-019043-cqmqwl3i 106 21 survivors survivor NNS cord-019043-cqmqwl3i 106 22 remains remain VBZ cord-019043-cqmqwl3i 106 23 severely severely RB cord-019043-cqmqwl3i 106 24 burdensome burdensome JJ cord-019043-cqmqwl3i 106 25 . . . cord-019043-cqmqwl3i 107 1 The the DT cord-019043-cqmqwl3i 107 2 development development NN cord-019043-cqmqwl3i 107 3 of of IN cord-019043-cqmqwl3i 107 4 AKI AKI NNP cord-019043-cqmqwl3i 107 5 or or CC cord-019043-cqmqwl3i 107 6 worsening worsen VBG cord-019043-cqmqwl3i 107 7 kidney kidney NN cord-019043-cqmqwl3i 107 8 function function NN cord-019043-cqmqwl3i 107 9 in in IN cord-019043-cqmqwl3i 107 10 the the DT cord-019043-cqmqwl3i 107 11 setting setting NN cord-019043-cqmqwl3i 107 12 of of IN cord-019043-cqmqwl3i 107 13 ARDS ARDS NNP cord-019043-cqmqwl3i 107 14 is be VBZ cord-019043-cqmqwl3i 107 15 common common JJ cord-019043-cqmqwl3i 107 16 , , , cord-019043-cqmqwl3i 107 17 occurring occur VBG cord-019043-cqmqwl3i 107 18 in in IN cord-019043-cqmqwl3i 107 19 excess excess NN cord-019043-cqmqwl3i 107 20 of of IN cord-019043-cqmqwl3i 107 21 35 35 CD cord-019043-cqmqwl3i 107 22 % % NN cord-019043-cqmqwl3i 107 23 , , , cord-019043-cqmqwl3i 107 24 and and CC cord-019043-cqmqwl3i 107 25 has have VBZ cord-019043-cqmqwl3i 107 26 an an DT cord-019043-cqmqwl3i 107 27 important important JJ cord-019043-cqmqwl3i 107 28 modifying modify VBG cord-019043-cqmqwl3i 107 29 impact impact NN cord-019043-cqmqwl3i 107 30 on on IN cord-019043-cqmqwl3i 107 31 increasing increase VBG cord-019043-cqmqwl3i 107 32 mortality mortality NN cord-019043-cqmqwl3i 107 33 risk risk NN cord-019043-cqmqwl3i 107 34 ( ( -LRB- cord-019043-cqmqwl3i 107 35 60 60 CD cord-019043-cqmqwl3i 107 36 - - SYM cord-019043-cqmqwl3i 107 37 80 80 CD cord-019043-cqmqwl3i 107 38 % % NN cord-019043-cqmqwl3i 107 39 ) ) -RRB- cord-019043-cqmqwl3i 108 1 [ [ -LRB- cord-019043-cqmqwl3i 108 2 4 4 CD cord-019043-cqmqwl3i 108 3 ] ] -RRB- cord-019043-cqmqwl3i 108 4 . . . cord-019043-cqmqwl3i 109 1 It -PRON- PRP cord-019043-cqmqwl3i 109 2 is be VBZ cord-019043-cqmqwl3i 109 3 believed believe VBN cord-019043-cqmqwl3i 109 4 part part NN cord-019043-cqmqwl3i 109 5 of of IN cord-019043-cqmqwl3i 109 6 the the DT cord-019043-cqmqwl3i 109 7 attributable attributable JJ cord-019043-cqmqwl3i 109 8 mortality mortality NN cord-019043-cqmqwl3i 109 9 in in IN cord-019043-cqmqwl3i 109 10 ARDS ARDS NNP cord-019043-cqmqwl3i 109 11 has have VBZ cord-019043-cqmqwl3i 109 12 been be VBN cord-019043-cqmqwl3i 109 13 related relate VBN cord-019043-cqmqwl3i 109 14 to to IN cord-019043-cqmqwl3i 109 15 the the DT cord-019043-cqmqwl3i 109 16 development development NN cord-019043-cqmqwl3i 109 17 of of IN cord-019043-cqmqwl3i 109 18 secondary secondary JJ cord-019043-cqmqwl3i 109 19 harm harm NN cord-019043-cqmqwl3i 109 20 associated associate VBN cord-019043-cqmqwl3i 109 21 with with IN cord-019043-cqmqwl3i 109 22 the the DT cord-019043-cqmqwl3i 109 23 mechanical mechanical JJ cord-019043-cqmqwl3i 109 24 ventilator ventilator NN cord-019043-cqmqwl3i 109 25 ( ( -LRB- cord-019043-cqmqwl3i 109 26 i.e. i.e. FW cord-019043-cqmqwl3i 109 27 , , , cord-019043-cqmqwl3i 109 28 VILI VILI NNP cord-019043-cqmqwl3i 109 29 ) ) -RRB- cord-019043-cqmqwl3i 109 30 . . . cord-019043-cqmqwl3i 110 1 Accordingly accordingly RB cord-019043-cqmqwl3i 110 2 , , , cord-019043-cqmqwl3i 110 3 a a DT cord-019043-cqmqwl3i 110 4 number number NN cord-019043-cqmqwl3i 110 5 of of IN cord-019043-cqmqwl3i 110 6 " " `` cord-019043-cqmqwl3i 110 7 lung lung NN cord-019043-cqmqwl3i 110 8 protective protective NN cord-019043-cqmqwl3i 110 9 " " '' cord-019043-cqmqwl3i 110 10 strategies strategy NNS cord-019043-cqmqwl3i 110 11 for for IN cord-019043-cqmqwl3i 110 12 improving improve VBG cord-019043-cqmqwl3i 110 13 outcome outcome NN cord-019043-cqmqwl3i 110 14 in in IN cord-019043-cqmqwl3i 110 15 ARDS ARDS NNP cord-019043-cqmqwl3i 110 16 have have VBP cord-019043-cqmqwl3i 110 17 been be VBN cord-019043-cqmqwl3i 110 18 evaluated evaluate VBN cord-019043-cqmqwl3i 110 19 ( ( -LRB- cord-019043-cqmqwl3i 110 20 Table table NN cord-019043-cqmqwl3i 110 21 32 32 CD cord-019043-cqmqwl3i 110 22 .4 .4 CD cord-019043-cqmqwl3i 110 23 ) ) -RRB- cord-019043-cqmqwl3i 110 24 . . . cord-019043-cqmqwl3i 111 1 The the DT cord-019043-cqmqwl3i 111 2 advent advent NN cord-019043-cqmqwl3i 111 3 of of IN cord-019043-cqmqwl3i 111 4 open open JJ cord-019043-cqmqwl3i 111 5 lung lung NN cord-019043-cqmqwl3i 111 6 low low NN cord-019043-cqmqwl3i 111 7 tidal tidal JJ cord-019043-cqmqwl3i 111 8 volume volume NN cord-019043-cqmqwl3i 111 9 ventilation ventilation NN cord-019043-cqmqwl3i 111 10 to to TO cord-019043-cqmqwl3i 111 11 prevent prevent VB cord-019043-cqmqwl3i 111 12 alveolar alveolar NN cord-019043-cqmqwl3i 111 13 overdistension overdistension NN cord-019043-cqmqwl3i 111 14 , , , cord-019043-cqmqwl3i 111 15 cyclic cyclic JJ cord-019043-cqmqwl3i 111 16 collapse collapse NN cord-019043-cqmqwl3i 111 17 , , , cord-019043-cqmqwl3i 111 18 and and CC cord-019043-cqmqwl3i 111 19 barotrauma barotrauma NN cord-019043-cqmqwl3i 111 20 may may MD cord-019043-cqmqwl3i 111 21 be be VB cord-019043-cqmqwl3i 111 22 associated associate VBN cord-019043-cqmqwl3i 111 23 with with IN cord-019043-cqmqwl3i 111 24 iatrogenic iatrogenic JJ cord-019043-cqmqwl3i 111 25 alveolar alveolar NN cord-019043-cqmqwl3i 111 26 hypoventilation hypoventilation NN cord-019043-cqmqwl3i 111 27 and and CC cord-019043-cqmqwl3i 111 28 hypercarbic hypercarbic JJ cord-019043-cqmqwl3i 111 29 respiratory respiratory JJ cord-019043-cqmqwl3i 111 30 acidosis acidosis NN cord-019043-cqmqwl3i 111 31 . . . cord-019043-cqmqwl3i 112 1 This this DT cord-019043-cqmqwl3i 112 2 may may MD cord-019043-cqmqwl3i 112 3 be be VB cord-019043-cqmqwl3i 112 4 poorly poorly RB cord-019043-cqmqwl3i 112 5 tolerated tolerate VBN cord-019043-cqmqwl3i 112 6 in in IN cord-019043-cqmqwl3i 112 7 patients patient NNS cord-019043-cqmqwl3i 112 8 with with IN cord-019043-cqmqwl3i 112 9 AKI AKI NNP cord-019043-cqmqwl3i 112 10 or or CC cord-019043-cqmqwl3i 112 11 CKD CKD NNP cord-019043-cqmqwl3i 112 12 / / SYM cord-019043-cqmqwl3i 112 13 ESRD ESRD NNP cord-019043-cqmqwl3i 112 14 with with IN cord-019043-cqmqwl3i 112 15 loss loss NN cord-019043-cqmqwl3i 112 16 of of IN cord-019043-cqmqwl3i 112 17 renal renal JJ cord-019043-cqmqwl3i 112 18 compensation compensation NN cord-019043-cqmqwl3i 112 19 and and CC cord-019043-cqmqwl3i 112 20 inability inability NN cord-019043-cqmqwl3i 112 21 to to TO cord-019043-cqmqwl3i 112 22 buffer buffer VB cord-019043-cqmqwl3i 112 23 the the DT cord-019043-cqmqwl3i 112 24 accumulated accumulate VBN cord-019043-cqmqwl3i 112 25 CO co NN cord-019043-cqmqwl3i 112 26 2 2 CD cord-019043-cqmqwl3i 112 27 . . . cord-019043-cqmqwl3i 113 1 These these DT cord-019043-cqmqwl3i 113 2 patients patient NNS cord-019043-cqmqwl3i 113 3 are be VBP cord-019043-cqmqwl3i 113 4 likely likely JJ cord-019043-cqmqwl3i 113 5 to to TO cord-019043-cqmqwl3i 113 6 require require VB cord-019043-cqmqwl3i 113 7 early early JJ cord-019043-cqmqwl3i 113 8 initiation initiation NN cord-019043-cqmqwl3i 113 9 of of IN cord-019043-cqmqwl3i 113 10 RRT RRT NNP cord-019043-cqmqwl3i 113 11 to to TO cord-019043-cqmqwl3i 113 12 mitigate mitigate VB cord-019043-cqmqwl3i 113 13 severe severe JJ cord-019043-cqmqwl3i 113 14 acidemia acidemia NN cord-019043-cqmqwl3i 113 15 and and CC cord-019043-cqmqwl3i 113 16 excessive excessive JJ cord-019043-cqmqwl3i 113 17 fluid fluid JJ cord-019043-cqmqwl3i 113 18 accumulation accumulation NN cord-019043-cqmqwl3i 113 19 . . . cord-019043-cqmqwl3i 114 1 Patients patient NNS cord-019043-cqmqwl3i 114 2 with with IN cord-019043-cqmqwl3i 114 3 CKD CKD NNP cord-019043-cqmqwl3i 114 4 / / SYM cord-019043-cqmqwl3i 114 5 ESRD ESRD NNP cord-019043-cqmqwl3i 114 6 are be VBP cord-019043-cqmqwl3i 114 7 more more RBR cord-019043-cqmqwl3i 114 8 susceptible susceptible JJ cord-019043-cqmqwl3i 114 9 to to IN cord-019043-cqmqwl3i 114 10 fluid fluid JJ cord-019043-cqmqwl3i 114 11 and and CC cord-019043-cqmqwl3i 114 12 metabolic metabolic JJ cord-019043-cqmqwl3i 114 13 complications complication NNS cord-019043-cqmqwl3i 114 14 due due JJ cord-019043-cqmqwl3i 114 15 to to IN cord-019043-cqmqwl3i 114 16 impaired impaired JJ cord-019043-cqmqwl3i 114 17 fluid fluid NN cord-019043-cqmqwl3i 114 18 , , , cord-019043-cqmqwl3i 114 19 electrolyte electrolyte NN cord-019043-cqmqwl3i 114 20 , , , cord-019043-cqmqwl3i 114 21 and and CC cord-019043-cqmqwl3i 114 22 acid acid NN cord-019043-cqmqwl3i 114 23 - - HYPH cord-019043-cqmqwl3i 114 24 base base NN cord-019043-cqmqwl3i 114 25 homeostasis homeostasis NN cord-019043-cqmqwl3i 114 26 . . . cord-019043-cqmqwl3i 115 1 Early early JJ cord-019043-cqmqwl3i 115 2 short short JJ cord-019043-cqmqwl3i 115 3 - - HYPH cord-019043-cqmqwl3i 115 4 term term NN cord-019043-cqmqwl3i 115 5 use use NN cord-019043-cqmqwl3i 115 6 of of IN cord-019043-cqmqwl3i 115 7 continuous continuous JJ cord-019043-cqmqwl3i 115 8 NMB NMB NNP cord-019043-cqmqwl3i 115 9 ( ( -LRB- cord-019043-cqmqwl3i 115 10 < < NNP cord-019043-cqmqwl3i 115 11 48 48 CD cord-019043-cqmqwl3i 115 12 h h NNP cord-019043-cqmqwl3i 115 13 ) ) -RRB- cord-019043-cqmqwl3i 115 14 in in IN cord-019043-cqmqwl3i 115 15 severe severe JJ cord-019043-cqmqwl3i 115 16 ARDS ARDS NNP cord-019043-cqmqwl3i 115 17 may may MD cord-019043-cqmqwl3i 115 18 improve improve VB cord-019043-cqmqwl3i 115 19 gas gas NN cord-019043-cqmqwl3i 115 20 exchange exchange NN cord-019043-cqmqwl3i 115 21 and and CC cord-019043-cqmqwl3i 115 22 reduce reduce VB cord-019043-cqmqwl3i 115 23 VILI VILI NNP cord-019043-cqmqwl3i 116 1 Recent recent JJ cord-019043-cqmqwl3i 116 2 level level NN cord-019043-cqmqwl3i 117 1 I -PRON- PRP cord-019043-cqmqwl3i 117 2 evidence evidence NN cord-019043-cqmqwl3i 117 3 found find VBD cord-019043-cqmqwl3i 117 4 lower low JJR cord-019043-cqmqwl3i 117 5 28-day 28-day CD cord-019043-cqmqwl3i 117 6 and and CC cord-019043-cqmqwl3i 117 7 hospital hospital NN cord-019043-cqmqwl3i 117 8 mortality mortality NN cord-019043-cqmqwl3i 117 9 associated associate VBN cord-019043-cqmqwl3i 117 10 with with IN cord-019043-cqmqwl3i 117 11 a a DT cord-019043-cqmqwl3i 117 12 strategy strategy NN cord-019043-cqmqwl3i 117 13 of of IN cord-019043-cqmqwl3i 117 14 early early JJ cord-019043-cqmqwl3i 117 15 short short JJ cord-019043-cqmqwl3i 117 16 - - HYPH cord-019043-cqmqwl3i 117 17 term term NN cord-019043-cqmqwl3i 117 18 continuous continuous JJ cord-019043-cqmqwl3i 117 19 infusion infusion NN cord-019043-cqmqwl3i 117 20 of of IN cord-019043-cqmqwl3i 117 21 NMB NMB NNP cord-019043-cqmqwl3i 117 22 in in IN cord-019043-cqmqwl3i 117 23 severe severe JJ cord-019043-cqmqwl3i 117 24 ARDS ARDS NNP cord-019043-cqmqwl3i 117 25 and and CC cord-019043-cqmqwl3i 117 26 no no DT cord-019043-cqmqwl3i 117 27 increase increase NN cord-019043-cqmqwl3i 117 28 in in IN cord-019043-cqmqwl3i 117 29 the the DT cord-019043-cqmqwl3i 117 30 rate rate NN cord-019043-cqmqwl3i 117 31 of of IN cord-019043-cqmqwl3i 117 32 ICU ICU NNP cord-019043-cqmqwl3i 117 33 - - HYPH cord-019043-cqmqwl3i 117 34 acquired acquire VBN cord-019043-cqmqwl3i 117 35 weakness weakness NN cord-019043-cqmqwl3i 117 36 Daily Daily NNP cord-019043-cqmqwl3i 117 37 sedation sedation NN cord-019043-cqmqwl3i 117 38 interruption interruption NN cord-019043-cqmqwl3i 118 1 A a DT cord-019043-cqmqwl3i 118 2 strategy strategy NN cord-019043-cqmqwl3i 118 3 of of IN cord-019043-cqmqwl3i 118 4 daily daily JJ cord-019043-cqmqwl3i 118 5 interruption interruption NN cord-019043-cqmqwl3i 118 6 or or CC cord-019043-cqmqwl3i 118 7 minimal minimal JJ cord-019043-cqmqwl3i 118 8 sedation sedation NN cord-019043-cqmqwl3i 118 9 has have VBZ cord-019043-cqmqwl3i 118 10 been be VBN cord-019043-cqmqwl3i 118 11 advocated advocate VBN cord-019043-cqmqwl3i 118 12 to to TO cord-019043-cqmqwl3i 118 13 reduce reduce VB cord-019043-cqmqwl3i 118 14 duration duration NN cord-019043-cqmqwl3i 118 15 of of IN cord-019043-cqmqwl3i 118 16 ventilation ventilation NN cord-019043-cqmqwl3i 118 17 , , , cord-019043-cqmqwl3i 118 18 duration duration NN cord-019043-cqmqwl3i 118 19 of of IN cord-019043-cqmqwl3i 118 20 ICU ICU NNP cord-019043-cqmqwl3i 118 21 stay stay NN cord-019043-cqmqwl3i 118 22 , , , cord-019043-cqmqwl3i 118 23 and and CC cord-019043-cqmqwl3i 118 24 the the DT cord-019043-cqmqwl3i 118 25 incidence incidence NN cord-019043-cqmqwl3i 118 26 of of IN cord-019043-cqmqwl3i 118 27 delirium delirium NN cord-019043-cqmqwl3i 119 1 These these DT cord-019043-cqmqwl3i 119 2 patients patient NNS cord-019043-cqmqwl3i 119 3 did do VBD cord-019043-cqmqwl3i 119 4 not not RB cord-019043-cqmqwl3i 119 5 necessarily necessarily RB cord-019043-cqmqwl3i 119 6 have have VB cord-019043-cqmqwl3i 119 7 ARDS ARDS NNP cord-019043-cqmqwl3i 119 8 . . . cord-019043-cqmqwl3i 120 1 Recent recent JJ cord-019043-cqmqwl3i 120 2 level level NN cord-019043-cqmqwl3i 120 3 I -PRON- PRP cord-019043-cqmqwl3i 120 4 evidence evidence NN cord-019043-cqmqwl3i 120 5 did do VBD cord-019043-cqmqwl3i 120 6 not not RB cord-019043-cqmqwl3i 120 7 show show VB cord-019043-cqmqwl3i 120 8 evidence evidence NN cord-019043-cqmqwl3i 120 9 of of IN cord-019043-cqmqwl3i 120 10 reduced reduce VBN cord-019043-cqmqwl3i 120 11 duration duration NN cord-019043-cqmqwl3i 120 12 of of IN cord-019043-cqmqwl3i 120 13 ventilation ventilation NN cord-019043-cqmqwl3i 120 14 or or CC cord-019043-cqmqwl3i 120 15 delirium delirium NN cord-019043-cqmqwl3i 120 16 associated associate VBN cord-019043-cqmqwl3i 120 17 with with IN cord-019043-cqmqwl3i 120 18 daily daily JJ cord-019043-cqmqwl3i 120 19 sedation sedation NN cord-019043-cqmqwl3i 120 20 interruption interruption NN cord-019043-cqmqwl3i 120 21 among among IN cord-019043-cqmqwl3i 120 22 ventilated ventilate VBN cord-019043-cqmqwl3i 120 23 patients patient NNS cord-019043-cqmqwl3i 120 24 receiving receive VBG cord-019043-cqmqwl3i 120 25 a a DT cord-019043-cqmqwl3i 120 26 sedation sedation NN cord-019043-cqmqwl3i 120 27 protocol protocol NN cord-019043-cqmqwl3i 120 28 Conservative conservative JJ cord-019043-cqmqwl3i 120 29 versus versus IN cord-019043-cqmqwl3i 120 30 liberal liberal JJ cord-019043-cqmqwl3i 120 31 fluid fluid JJ cord-019043-cqmqwl3i 120 32 therapy therapy NN cord-019043-cqmqwl3i 120 33 strategy strategy NN cord-019043-cqmqwl3i 121 1 The the DT cord-019043-cqmqwl3i 121 2 rationale rationale NN cord-019043-cqmqwl3i 121 3 for for IN cord-019043-cqmqwl3i 121 4 a a DT cord-019043-cqmqwl3i 121 5 conservative conservative JJ cord-019043-cqmqwl3i 121 6 fluid fluid JJ cord-019043-cqmqwl3i 121 7 management management NN cord-019043-cqmqwl3i 121 8 strategy strategy NN cord-019043-cqmqwl3i 121 9 is be VBZ cord-019043-cqmqwl3i 121 10 based base VBN cord-019043-cqmqwl3i 121 11 on on IN cord-019043-cqmqwl3i 121 12 the the DT cord-019043-cqmqwl3i 121 13 premise premise NN cord-019043-cqmqwl3i 121 14 of of IN cord-019043-cqmqwl3i 121 15 minimizing minimize VBG cord-019043-cqmqwl3i 121 16 nonessential nonessential JJ cord-019043-cqmqwl3i 121 17 fluid fluid JJ cord-019043-cqmqwl3i 121 18 and and CC cord-019043-cqmqwl3i 121 19 active active JJ cord-019043-cqmqwl3i 121 20 removal removal NN cord-019043-cqmqwl3i 121 21 of of IN cord-019043-cqmqwl3i 121 22 excess excess JJ cord-019043-cqmqwl3i 121 23 fluid fluid NN cord-019043-cqmqwl3i 121 24 once once IN cord-019043-cqmqwl3i 121 25 physiologic physiologic JJ cord-019043-cqmqwl3i 121 26 stability stability NN cord-019043-cqmqwl3i 121 27 was be VBD cord-019043-cqmqwl3i 121 28 achieved achieve VBN cord-019043-cqmqwl3i 121 29 Recent recent JJ cord-019043-cqmqwl3i 121 30 level level NN cord-019043-cqmqwl3i 121 31 I -PRON- PRP cord-019043-cqmqwl3i 121 32 evidence evidence NN cord-019043-cqmqwl3i 121 33 found find VBD cord-019043-cqmqwl3i 121 34 that that IN cord-019043-cqmqwl3i 121 35 a a DT cord-019043-cqmqwl3i 121 36 conservative conservative JJ cord-019043-cqmqwl3i 121 37 fluid fluid JJ cord-019043-cqmqwl3i 121 38 strategy strategy NN cord-019043-cqmqwl3i 121 39 , , , cord-019043-cqmqwl3i 121 40 compared compare VBN cord-019043-cqmqwl3i 121 41 with with IN cord-019043-cqmqwl3i 121 42 a a DT cord-019043-cqmqwl3i 121 43 liberal liberal JJ cord-019043-cqmqwl3i 121 44 fluid fluid JJ cord-019043-cqmqwl3i 121 45 strategy strategy NN cord-019043-cqmqwl3i 121 46 , , , cord-019043-cqmqwl3i 121 47 resulted result VBD cord-019043-cqmqwl3i 121 48 in in IN cord-019043-cqmqwl3i 121 49 a a DT cord-019043-cqmqwl3i 121 50 nonsignificant nonsignificant JJ cord-019043-cqmqwl3i 121 51 reduction reduction NN cord-019043-cqmqwl3i 121 52 in in IN cord-019043-cqmqwl3i 121 53 mortality mortality NN cord-019043-cqmqwl3i 121 54 and and CC cord-019043-cqmqwl3i 121 55 significant significant JJ cord-019043-cqmqwl3i 121 56 shorter short JJR cord-019043-cqmqwl3i 121 57 durations duration NNS cord-019043-cqmqwl3i 121 58 of of IN cord-019043-cqmqwl3i 121 59 mechanical mechanical JJ cord-019043-cqmqwl3i 121 60 ventilation ventilation NN cord-019043-cqmqwl3i 121 61 , , , cord-019043-cqmqwl3i 121 62 ICU ICU NNP cord-019043-cqmqwl3i 121 63 stay stay VBP cord-019043-cqmqwl3i 121 64 , , , cord-019043-cqmqwl3i 121 65 and and CC cord-019043-cqmqwl3i 121 66 trends trend NNS cord-019043-cqmqwl3i 121 67 for for IN cord-019043-cqmqwl3i 121 68 lower low JJR cord-019043-cqmqwl3i 121 69 utilization utilization NN cord-019043-cqmqwl3i 121 70 of of IN cord-019043-cqmqwl3i 121 71 RRT RRT NNP cord-019043-cqmqwl3i 121 72 . . . cord-019043-cqmqwl3i 122 1 These these DT cord-019043-cqmqwl3i 122 2 findings finding NNS cord-019043-cqmqwl3i 122 3 were be VBD cord-019043-cqmqwl3i 122 4 similar similar JJ cord-019043-cqmqwl3i 122 5 for for IN cord-019043-cqmqwl3i 122 6 the the DT cord-019043-cqmqwl3i 122 7 subgroup subgroup NN cord-019043-cqmqwl3i 122 8 with with IN cord-019043-cqmqwl3i 122 9 AKI AKI NNP cord-019043-cqmqwl3i 122 10 Prone Prone NNP cord-019043-cqmqwl3i 122 11 positioning positioning NN cord-019043-cqmqwl3i 122 12 ARDS ARDS NNP cord-019043-cqmqwl3i 122 13 is be VBZ cord-019043-cqmqwl3i 122 14 often often RB cord-019043-cqmqwl3i 122 15 a a DT cord-019043-cqmqwl3i 122 16 heterogeneous heterogeneous JJ cord-019043-cqmqwl3i 122 17 syndrome syndrome NN cord-019043-cqmqwl3i 122 18 with with IN cord-019043-cqmqwl3i 122 19 worse bad JJR cord-019043-cqmqwl3i 122 20 air air NN cord-019043-cqmqwl3i 122 21 space space NN cord-019043-cqmqwl3i 122 22 consolidation consolidation NN cord-019043-cqmqwl3i 122 23 in in IN cord-019043-cqmqwl3i 122 24 basal basal NN cord-019043-cqmqwl3i 122 25 ( ( -LRB- cord-019043-cqmqwl3i 122 26 dependent dependent JJ cord-019043-cqmqwl3i 122 27 ) ) -RRB- cord-019043-cqmqwl3i 122 28 lung lung NN cord-019043-cqmqwl3i 122 29 segments segment NNS cord-019043-cqmqwl3i 122 30 . . . cord-019043-cqmqwl3i 123 1 The the DT cord-019043-cqmqwl3i 123 2 rationale rationale NN cord-019043-cqmqwl3i 123 3 for for IN cord-019043-cqmqwl3i 123 4 prone prone JJ cord-019043-cqmqwl3i 123 5 positioning positioning NN cord-019043-cqmqwl3i 123 6 is be VBZ cord-019043-cqmqwl3i 123 7 to to TO cord-019043-cqmqwl3i 123 8 improve improve VB cord-019043-cqmqwl3i 123 9 V V NNP cord-019043-cqmqwl3i 123 10 / / SYM cord-019043-cqmqwl3i 123 11 Q q NN cord-019043-cqmqwl3i 123 12 matching matching NN cord-019043-cqmqwl3i 123 13 and and CC cord-019043-cqmqwl3i 123 14 reduce reduce VB cord-019043-cqmqwl3i 123 15 VILI VILI NNP cord-019043-cqmqwl3i 123 16 by by IN cord-019043-cqmqwl3i 123 17 having have VBG cord-019043-cqmqwl3i 123 18 patients patient NNS cord-019043-cqmqwl3i 123 19 in in IN cord-019043-cqmqwl3i 123 20 prone prone JJ cord-019043-cqmqwl3i 123 21 position position NN cord-019043-cqmqwl3i 123 22 for for IN cord-019043-cqmqwl3i 123 23 12 12 CD cord-019043-cqmqwl3i 123 24 - - SYM cord-019043-cqmqwl3i 123 25 16 16 CD cord-019043-cqmqwl3i 123 26 h h NN cord-019043-cqmqwl3i 123 27 per per IN cord-019043-cqmqwl3i 123 28 day day NN cord-019043-cqmqwl3i 123 29 Prior prior JJ cord-019043-cqmqwl3i 123 30 trials trial NNS cord-019043-cqmqwl3i 123 31 have have VBP cord-019043-cqmqwl3i 123 32 found find VBN cord-019043-cqmqwl3i 123 33 prone prone JJ cord-019043-cqmqwl3i 123 34 positioning positioning NN cord-019043-cqmqwl3i 123 35 improves improve VBZ cord-019043-cqmqwl3i 123 36 oxygenation oxygenation NN cord-019043-cqmqwl3i 123 37 ; ; : cord-019043-cqmqwl3i 123 38 and and CC cord-019043-cqmqwl3i 123 39 recent recent JJ cord-019043-cqmqwl3i 123 40 level level NN cord-019043-cqmqwl3i 123 41 I -PRON- PRP cord-019043-cqmqwl3i 123 42 evidence evidence NN cord-019043-cqmqwl3i 123 43 found find VBD cord-019043-cqmqwl3i 123 44 a a DT cord-019043-cqmqwl3i 123 45 strategy strategy NN cord-019043-cqmqwl3i 123 46 of of IN cord-019043-cqmqwl3i 123 47 early early JJ cord-019043-cqmqwl3i 123 48 prone prone JJ cord-019043-cqmqwl3i 123 49 positioning positioning NN cord-019043-cqmqwl3i 123 50 was be VBD cord-019043-cqmqwl3i 123 51 associated associate VBN cord-019043-cqmqwl3i 123 52 with with IN cord-019043-cqmqwl3i 123 53 improved improved JJ cord-019043-cqmqwl3i 123 54 survival survival NN cord-019043-cqmqwl3i 123 55 at at IN cord-019043-cqmqwl3i 123 56 28 28 CD cord-019043-cqmqwl3i 123 57 and and CC cord-019043-cqmqwl3i 123 58 90 90 CD cord-019043-cqmqwl3i 123 59 days day NNS cord-019043-cqmqwl3i 123 60 . . . cord-019043-cqmqwl3i 124 1 Prone prone JJ cord-019043-cqmqwl3i 124 2 positioning positioning NN cord-019043-cqmqwl3i 124 3 should should MD cord-019043-cqmqwl3i 124 4 be be VB cord-019043-cqmqwl3i 124 5 protocolized protocolize VBN cord-019043-cqmqwl3i 124 6 The the DT cord-019043-cqmqwl3i 124 7 rationale rationale NN cord-019043-cqmqwl3i 124 8 for for IN cord-019043-cqmqwl3i 124 9 inhaled inhale VBN cord-019043-cqmqwl3i 124 10 vasodilators vasodilator NNS cord-019043-cqmqwl3i 124 11 , , , cord-019043-cqmqwl3i 124 12 by by IN cord-019043-cqmqwl3i 124 13 reducing reduce VBG cord-019043-cqmqwl3i 124 14 PVR pvr NN cord-019043-cqmqwl3i 124 15 and and CC cord-019043-cqmqwl3i 124 16 improving improve VBG cord-019043-cqmqwl3i 124 17 V v NN cord-019043-cqmqwl3i 124 18 / / SYM cord-019043-cqmqwl3i 124 19 Q q NN cord-019043-cqmqwl3i 124 20 matching match VBG cord-019043-cqmqwl3i 124 21 in in IN cord-019043-cqmqwl3i 124 22 ARDS ARDS NNP cord-019043-cqmqwl3i 124 23 , , , cord-019043-cqmqwl3i 124 24 can can MD cord-019043-cqmqwl3i 124 25 improve improve VB cord-019043-cqmqwl3i 124 26 oxygenation oxygenation NN cord-019043-cqmqwl3i 125 1 Meta Meta NNP cord-019043-cqmqwl3i 125 2 - - HYPH cord-019043-cqmqwl3i 125 3 analyses analysis NNS cord-019043-cqmqwl3i 125 4 of of IN cord-019043-cqmqwl3i 125 5 small small JJ cord-019043-cqmqwl3i 125 6 randomized randomized JJ cord-019043-cqmqwl3i 125 7 trials trial NNS cord-019043-cqmqwl3i 125 8 have have VBP cord-019043-cqmqwl3i 125 9 found find VBN cord-019043-cqmqwl3i 125 10 no no DT cord-019043-cqmqwl3i 125 11 improvement improvement NN cord-019043-cqmqwl3i 125 12 in in IN cord-019043-cqmqwl3i 125 13 mortality mortality NN cord-019043-cqmqwl3i 125 14 with with IN cord-019043-cqmqwl3i 125 15 inhaled inhale VBN cord-019043-cqmqwl3i 125 16 vasodilators vasodilator NNS cord-019043-cqmqwl3i 125 17 for for IN cord-019043-cqmqwl3i 125 18 ARDS ARDS NNP cord-019043-cqmqwl3i 125 19 ; ; : cord-019043-cqmqwl3i 125 20 however however RB cord-019043-cqmqwl3i 125 21 , , , cord-019043-cqmqwl3i 125 22 it -PRON- PRP cord-019043-cqmqwl3i 125 23 was be VBD cord-019043-cqmqwl3i 125 24 associated associate VBN cord-019043-cqmqwl3i 125 25 with with IN cord-019043-cqmqwl3i 125 26 transient transient JJ cord-019043-cqmqwl3i 125 27 improvements improvement NNS cord-019043-cqmqwl3i 125 28 in in IN cord-019043-cqmqwl3i 125 29 oxygenation oxygenation NN cord-019043-cqmqwl3i 125 30 and and CC cord-019043-cqmqwl3i 125 31 increased increase VBN cord-019043-cqmqwl3i 125 32 risk risk NN cord-019043-cqmqwl3i 125 33 of of IN cord-019043-cqmqwl3i 125 34 AKI AKI NNP cord-019043-cqmqwl3i 125 35 . . . cord-019043-cqmqwl3i 126 1 Inhaled inhale VBN cord-019043-cqmqwl3i 126 2 vasodilators vasodilator NNS cord-019043-cqmqwl3i 126 3 are be VBP cord-019043-cqmqwl3i 126 4 a a DT cord-019043-cqmqwl3i 126 5 reasonable reasonable JJ cord-019043-cqmqwl3i 126 6 salvage salvage NN cord-019043-cqmqwl3i 126 7 therapy therapy NN cord-019043-cqmqwl3i 126 8 for for IN cord-019043-cqmqwl3i 126 9 refractory refractory JJ cord-019043-cqmqwl3i 126 10 hypoxemia hypoxemia NN cord-019043-cqmqwl3i 126 11 Highfrequency Highfrequency NNP cord-019043-cqmqwl3i 126 12 oscillatory oscillatory JJ cord-019043-cqmqwl3i 126 13 ventilation ventilation NN cord-019043-cqmqwl3i 126 14 ( ( -LRB- cord-019043-cqmqwl3i 126 15 HFOV HFOV NNP cord-019043-cqmqwl3i 126 16 ) ) -RRB- cord-019043-cqmqwl3i 127 1 The the DT cord-019043-cqmqwl3i 127 2 premise premise NN cord-019043-cqmqwl3i 127 3 for for IN cord-019043-cqmqwl3i 127 4 HFOV HFOV NNP cord-019043-cqmqwl3i 127 5 is be VBZ cord-019043-cqmqwl3i 127 6 to to TO cord-019043-cqmqwl3i 127 7 utilize utilize VB cord-019043-cqmqwl3i 127 8 subanatomical subanatomical JJ cord-019043-cqmqwl3i 127 9 tidal tidal JJ cord-019043-cqmqwl3i 127 10 volumes volume NNS cord-019043-cqmqwl3i 127 11 , , , cord-019043-cqmqwl3i 127 12 high high JJ cord-019043-cqmqwl3i 127 13 mean mean NN cord-019043-cqmqwl3i 127 14 airway airway NN cord-019043-cqmqwl3i 127 15 pressures pressure NNS cord-019043-cqmqwl3i 127 16 , , , cord-019043-cqmqwl3i 127 17 and and CC cord-019043-cqmqwl3i 127 18 high high JJ cord-019043-cqmqwl3i 127 19 respiratory respiratory JJ cord-019043-cqmqwl3i 127 20 rates rate NNS cord-019043-cqmqwl3i 127 21 to to TO cord-019043-cqmqwl3i 127 22 maintain maintain VB cord-019043-cqmqwl3i 127 23 open open JJ cord-019043-cqmqwl3i 127 24 lung lung NN cord-019043-cqmqwl3i 127 25 ventilation ventilation NN cord-019043-cqmqwl3i 127 26 , , , cord-019043-cqmqwl3i 127 27 minimize minimize VB cord-019043-cqmqwl3i 127 28 the the DT cord-019043-cqmqwl3i 127 29 risk risk NN cord-019043-cqmqwl3i 127 30 of of IN cord-019043-cqmqwl3i 127 31 VILI VILI NNP cord-019043-cqmqwl3i 127 32 , , , cord-019043-cqmqwl3i 127 33 and and CC cord-019043-cqmqwl3i 127 34 allow allow VB cord-019043-cqmqwl3i 127 35 lungs lung NNS cord-019043-cqmqwl3i 127 36 injury injury NN cord-019043-cqmqwl3i 127 37 to to TO cord-019043-cqmqwl3i 127 38 recover recover VB cord-019043-cqmqwl3i 127 39 Recent recent JJ cord-019043-cqmqwl3i 127 40 level level NN cord-019043-cqmqwl3i 127 41 I -PRON- PRP cord-019043-cqmqwl3i 127 42 evidence evidence NN cord-019043-cqmqwl3i 127 43 found find VBD cord-019043-cqmqwl3i 127 44 early early JJ cord-019043-cqmqwl3i 127 45 utilization utilization NN cord-019043-cqmqwl3i 127 46 of of IN cord-019043-cqmqwl3i 127 47 HFOV HFOV NNP cord-019043-cqmqwl3i 127 48 , , , cord-019043-cqmqwl3i 127 49 compared compare VBN cord-019043-cqmqwl3i 127 50 with with IN cord-019043-cqmqwl3i 127 51 standard standard JJ cord-019043-cqmqwl3i 127 52 lung lung NN cord-019043-cqmqwl3i 127 53 protective protective JJ cord-019043-cqmqwl3i 127 54 ventilation ventilation NN cord-019043-cqmqwl3i 127 55 , , , cord-019043-cqmqwl3i 127 56 was be VBD cord-019043-cqmqwl3i 127 57 associated associate VBN cord-019043-cqmqwl3i 127 58 with with IN cord-019043-cqmqwl3i 127 59 increased increase VBN cord-019043-cqmqwl3i 127 60 in in IN cord-019043-cqmqwl3i 127 61 - - HYPH cord-019043-cqmqwl3i 127 62 hospital hospital NN cord-019043-cqmqwl3i 127 63 mortality mortality NN cord-019043-cqmqwl3i 127 64 , , , cord-019043-cqmqwl3i 127 65 greater great JJR cord-019043-cqmqwl3i 127 66 use use NN cord-019043-cqmqwl3i 127 67 of of IN cord-019043-cqmqwl3i 127 68 sedation sedation NN cord-019043-cqmqwl3i 127 69 , , , cord-019043-cqmqwl3i 127 70 neuromuscular neuromuscular NN cord-019043-cqmqwl3i 127 71 blockade blockade NN cord-019043-cqmqwl3i 127 72 , , , cord-019043-cqmqwl3i 127 73 and and CC cord-019043-cqmqwl3i 127 74 vasoactive vasoactive JJ cord-019043-cqmqwl3i 127 75 therapy therapy NN cord-019043-cqmqwl3i 127 76 . . . cord-019043-cqmqwl3i 128 1 HFOV HFOV NNP cord-019043-cqmqwl3i 128 2 should should MD cord-019043-cqmqwl3i 128 3 be be VB cord-019043-cqmqwl3i 128 4 reserved reserve VBN cord-019043-cqmqwl3i 128 5 for for IN cord-019043-cqmqwl3i 128 6 salvage salvage NN cord-019043-cqmqwl3i 128 7 therapy therapy NN cord-019043-cqmqwl3i 128 8 in in IN cord-019043-cqmqwl3i 128 9 those those DT cord-019043-cqmqwl3i 128 10 with with IN cord-019043-cqmqwl3i 128 11 refractory refractory JJ cord-019043-cqmqwl3i 128 12 hypoxemia hypoxemia NN cord-019043-cqmqwl3i 128 13 Extracorporeal extracorporeal JJ cord-019043-cqmqwl3i 128 14 membrane membrane NN cord-019043-cqmqwl3i 128 15 oxygenation oxygenation NN cord-019043-cqmqwl3i 128 16 ( ( -LRB- cord-019043-cqmqwl3i 128 17 ECMO ECMO NNP cord-019043-cqmqwl3i 128 18 ) ) -RRB- cord-019043-cqmqwl3i 129 1 Candidates candidate NNS cord-019043-cqmqwl3i 129 2 should should MD cord-019043-cqmqwl3i 129 3 have have VB cord-019043-cqmqwl3i 129 4 potentially potentially RB cord-019043-cqmqwl3i 129 5 reversible reversible JJ cord-019043-cqmqwl3i 129 6 respiratory respiratory JJ cord-019043-cqmqwl3i 129 7 failure failure NN cord-019043-cqmqwl3i 129 8 , , , cord-019043-cqmqwl3i 129 9 severe severe JJ cord-019043-cqmqwl3i 129 10 hypoxemia hypoxemia NN cord-019043-cqmqwl3i 129 11 ( ( -LRB- cord-019043-cqmqwl3i 129 12 Murray Murray NNP cord-019043-cqmqwl3i 129 13 score score NN cord-019043-cqmqwl3i 129 14 > > XX cord-019043-cqmqwl3i 129 15 3.0 3.0 CD cord-019043-cqmqwl3i 129 16 ) ) -RRB- cord-019043-cqmqwl3i 129 17 , , , cord-019043-cqmqwl3i 129 18 ideally ideally RB cord-019043-cqmqwl3i 129 19 venovenous venovenous NNP cord-019043-cqmqwl3i 129 20 circuit circuit NN cord-019043-cqmqwl3i 129 21 via via IN cord-019043-cqmqwl3i 129 22 dual dual JJ cord-019043-cqmqwl3i 129 23 - - HYPH cord-019043-cqmqwl3i 129 24 lumen lumen NN cord-019043-cqmqwl3i 129 25 catheter catheter NN cord-019043-cqmqwl3i 129 26 , , , cord-019043-cqmqwl3i 129 27 early early JJ cord-019043-cqmqwl3i 129 28 referral referral NN cord-019043-cqmqwl3i 129 29 to to IN cord-019043-cqmqwl3i 129 30 experienced experienced JJ cord-019043-cqmqwl3i 129 31 centers center NNS cord-019043-cqmqwl3i 129 32 ECMO ECMO NNP cord-019043-cqmqwl3i 129 33 has have VBZ cord-019043-cqmqwl3i 129 34 generally generally RB cord-019043-cqmqwl3i 129 35 been be VBN cord-019043-cqmqwl3i 129 36 reserved reserve VBN cord-019043-cqmqwl3i 129 37 as as IN cord-019043-cqmqwl3i 129 38 salvage salvage NN cord-019043-cqmqwl3i 129 39 therapy therapy NN cord-019043-cqmqwl3i 129 40 for for IN cord-019043-cqmqwl3i 129 41 adult adult NN cord-019043-cqmqwl3i 129 42 patients patient NNS cord-019043-cqmqwl3i 129 43 ; ; : cord-019043-cqmqwl3i 129 44 however however RB cord-019043-cqmqwl3i 129 45 , , , cord-019043-cqmqwl3i 129 46 recent recent JJ cord-019043-cqmqwl3i 129 47 level level NN cord-019043-cqmqwl3i 130 1 I -PRON- PRP cord-019043-cqmqwl3i 130 2 evidence evidence VBP cord-019043-cqmqwl3i 130 3 from from IN cord-019043-cqmqwl3i 130 4 randomized randomized JJ cord-019043-cqmqwl3i 130 5 trials trial NNS cord-019043-cqmqwl3i 130 6 and and CC cord-019043-cqmqwl3i 130 7 observational observational JJ cord-019043-cqmqwl3i 130 8 data datum NNS cord-019043-cqmqwl3i 130 9 during during IN cord-019043-cqmqwl3i 130 10 the the DT cord-019043-cqmqwl3i 130 11 pH1N1 pH1N1 NNP cord-019043-cqmqwl3i 130 12 pandemic pandemic NN cord-019043-cqmqwl3i 130 13 found find VBD cord-019043-cqmqwl3i 130 14 reasonable reasonable JJ cord-019043-cqmqwl3i 130 15 survival survival NN cord-019043-cqmqwl3i 130 16 Fluid Fluid NNP cord-019043-cqmqwl3i 130 17 therapy therapy NN cord-019043-cqmqwl3i 130 18 is be VBZ cord-019043-cqmqwl3i 130 19 perhaps perhaps RB cord-019043-cqmqwl3i 130 20 the the DT cord-019043-cqmqwl3i 130 21 most most RBS cord-019043-cqmqwl3i 130 22 common common JJ cord-019043-cqmqwl3i 130 23 intervention intervention NN cord-019043-cqmqwl3i 130 24 received receive VBN cord-019043-cqmqwl3i 130 25 by by IN cord-019043-cqmqwl3i 130 26 critically critically RB cord-019043-cqmqwl3i 130 27 ill ill JJ cord-019043-cqmqwl3i 130 28 patients patient NNS cord-019043-cqmqwl3i 130 29 . . . cord-019043-cqmqwl3i 131 1 The the DT cord-019043-cqmqwl3i 131 2 key key JJ cord-019043-cqmqwl3i 131 3 concept concept NN cord-019043-cqmqwl3i 131 4 for for IN cord-019043-cqmqwl3i 131 5 dosing dose VBG cord-019043-cqmqwl3i 131 6 fluid fluid NN cord-019043-cqmqwl3i 131 7 therapy therapy NN cord-019043-cqmqwl3i 131 8 in in IN cord-019043-cqmqwl3i 131 9 critically critically RB cord-019043-cqmqwl3i 131 10 ill ill JJ cord-019043-cqmqwl3i 131 11 patients patient NNS cord-019043-cqmqwl3i 131 12 is be VBZ cord-019043-cqmqwl3i 131 13 to to TO cord-019043-cqmqwl3i 131 14 actively actively RB cord-019043-cqmqwl3i 131 15 address address VB cord-019043-cqmqwl3i 131 16 ongoing ongoing JJ cord-019043-cqmqwl3i 131 17 losses loss NNS cord-019043-cqmqwl3i 131 18 coupled couple VBN cord-019043-cqmqwl3i 131 19 with with IN cord-019043-cqmqwl3i 131 20 constant constant JJ cord-019043-cqmqwl3i 131 21 reassessment reassessment NN cord-019043-cqmqwl3i 131 22 of of IN cord-019043-cqmqwl3i 131 23 need need NN cord-019043-cqmqwl3i 131 24 for for IN cord-019043-cqmqwl3i 131 25 further further JJ cord-019043-cqmqwl3i 131 26 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 131 27 support support NN cord-019043-cqmqwl3i 131 28 . . . cord-019043-cqmqwl3i 132 1 While while IN cord-019043-cqmqwl3i 132 2 the the DT cord-019043-cqmqwl3i 132 3 optimal optimal JJ cord-019043-cqmqwl3i 132 4 endpoints endpoint NNS cord-019043-cqmqwl3i 132 5 for for IN cord-019043-cqmqwl3i 132 6 fluid fluid JJ cord-019043-cqmqwl3i 132 7 therapy therapy NN cord-019043-cqmqwl3i 132 8 during during IN cord-019043-cqmqwl3i 132 9 resuscitation resuscitation NN cord-019043-cqmqwl3i 132 10 remain remain VBP cord-019043-cqmqwl3i 132 11 controversial controversial JJ cord-019043-cqmqwl3i 132 12 , , , cord-019043-cqmqwl3i 132 13 increasing increase VBG cord-019043-cqmqwl3i 132 14 evidence evidence NN cord-019043-cqmqwl3i 132 15 suggests suggest VBZ cord-019043-cqmqwl3i 132 16 that that IN cord-019043-cqmqwl3i 132 17 resuscitation resuscitation NN cord-019043-cqmqwl3i 132 18 needs need VBZ cord-019043-cqmqwl3i 132 19 to to TO cord-019043-cqmqwl3i 132 20 be be VB cord-019043-cqmqwl3i 132 21 individualized individualize VBN cord-019043-cqmqwl3i 132 22 and and CC cord-019043-cqmqwl3i 132 23 that that IN cord-019043-cqmqwl3i 132 24 the the DT cord-019043-cqmqwl3i 132 25 integration integration NN cord-019043-cqmqwl3i 132 26 of of IN cord-019043-cqmqwl3i 132 27 functional functional JJ cord-019043-cqmqwl3i 132 28 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 132 29 measures measure NNS cord-019043-cqmqwl3i 132 30 to to TO cord-019043-cqmqwl3i 132 31 guide guide VB cord-019043-cqmqwl3i 132 32 fluid fluid JJ cord-019043-cqmqwl3i 132 33 responsiveness responsiveness NN cord-019043-cqmqwl3i 132 34 are be VBP cord-019043-cqmqwl3i 132 35 superior superior JJ cord-019043-cqmqwl3i 132 36 to to IN cord-019043-cqmqwl3i 132 37 static static JJ cord-019043-cqmqwl3i 132 38 measures measure NNS cord-019043-cqmqwl3i 132 39 of of IN cord-019043-cqmqwl3i 132 40 volume volume NN cord-019043-cqmqwl3i 132 41 status status NN cord-019043-cqmqwl3i 132 42 . . . cord-019043-cqmqwl3i 133 1 Fluid fluid JJ cord-019043-cqmqwl3i 133 2 therapy therapy NN cord-019043-cqmqwl3i 133 3 also also RB cord-019043-cqmqwl3i 133 4 represents represent VBZ cord-019043-cqmqwl3i 133 5 a a DT cord-019043-cqmqwl3i 133 6 central central JJ cord-019043-cqmqwl3i 133 7 cornerstone cornerstone NN cord-019043-cqmqwl3i 133 8 for for IN cord-019043-cqmqwl3i 133 9 the the DT cord-019043-cqmqwl3i 133 10 prevention prevention NN cord-019043-cqmqwl3i 133 11 and/or and/or CC cord-019043-cqmqwl3i 133 12 the the DT cord-019043-cqmqwl3i 133 13 management management NN cord-019043-cqmqwl3i 133 14 of of IN cord-019043-cqmqwl3i 133 15 AKI AKI NNP cord-019043-cqmqwl3i 133 16 . . . cord-019043-cqmqwl3i 134 1 Of of IN cord-019043-cqmqwl3i 134 2 the the DT cord-019043-cqmqwl3i 134 3 numerous numerous JJ cord-019043-cqmqwl3i 134 4 strategies strategy NNS cord-019043-cqmqwl3i 134 5 evaluated evaluate VBN cord-019043-cqmqwl3i 134 6 to to IN cord-019043-cqmqwl3i 134 7 date date NN cord-019043-cqmqwl3i 134 8 for for IN cord-019043-cqmqwl3i 134 9 prevention prevention NN cord-019043-cqmqwl3i 134 10 of of IN cord-019043-cqmqwl3i 134 11 AKI AKI NNP cord-019043-cqmqwl3i 134 12 , , , cord-019043-cqmqwl3i 134 13 only only RB cord-019043-cqmqwl3i 134 14 fluid fluid JJ cord-019043-cqmqwl3i 134 15 therapy therapy NN cord-019043-cqmqwl3i 134 16 has have VBZ cord-019043-cqmqwl3i 134 17 been be VBN cord-019043-cqmqwl3i 134 18 shown show VBN cord-019043-cqmqwl3i 134 19 to to TO cord-019043-cqmqwl3i 134 20 be be VB cord-019043-cqmqwl3i 134 21 consistently consistently RB cord-019043-cqmqwl3i 134 22 effective effective JJ cord-019043-cqmqwl3i 134 23 . . . cord-019043-cqmqwl3i 135 1 Importantly importantly RB cord-019043-cqmqwl3i 135 2 , , , cord-019043-cqmqwl3i 135 3 however however RB cord-019043-cqmqwl3i 135 4 , , , cord-019043-cqmqwl3i 135 5 there there EX cord-019043-cqmqwl3i 135 6 is be VBZ cord-019043-cqmqwl3i 135 7 no no DT cord-019043-cqmqwl3i 135 8 evidence evidence NN cord-019043-cqmqwl3i 135 9 that that IN cord-019043-cqmqwl3i 135 10 fluid fluid JJ cord-019043-cqmqwl3i 135 11 therapy therapy NN cord-019043-cqmqwl3i 135 12 will will MD cord-019043-cqmqwl3i 135 13 reverse reverse VB cord-019043-cqmqwl3i 135 14 AKI AKI NNP cord-019043-cqmqwl3i 135 15 once once RB cord-019043-cqmqwl3i 135 16 established establish VBN cord-019043-cqmqwl3i 135 17 . . . cord-019043-cqmqwl3i 136 1 Reduced reduce VBN cord-019043-cqmqwl3i 136 2 urine urine NN cord-019043-cqmqwl3i 136 3 output output NN cord-019043-cqmqwl3i 136 4 is be VBZ cord-019043-cqmqwl3i 136 5 common common JJ cord-019043-cqmqwl3i 136 6 and and CC cord-019043-cqmqwl3i 136 7 often often RB cord-019043-cqmqwl3i 136 8 precedes precede VBZ cord-019043-cqmqwl3i 136 9 overt overt JJ cord-019043-cqmqwl3i 136 10 AKI aki NN cord-019043-cqmqwl3i 136 11 ; ; : cord-019043-cqmqwl3i 136 12 however however RB cord-019043-cqmqwl3i 136 13 , , , cord-019043-cqmqwl3i 136 14 it -PRON- PRP cord-019043-cqmqwl3i 136 15 lacks lack VBZ cord-019043-cqmqwl3i 136 16 specificity specificity NN cord-019043-cqmqwl3i 136 17 . . . cord-019043-cqmqwl3i 137 1 Oliguria Oliguria NNP cord-019043-cqmqwl3i 137 2 in in IN cord-019043-cqmqwl3i 137 3 the the DT cord-019043-cqmqwl3i 137 4 absence absence NN cord-019043-cqmqwl3i 137 5 of of IN cord-019043-cqmqwl3i 137 6 clear clear JJ cord-019043-cqmqwl3i 137 7 hypovolemia hypovolemia NN cord-019043-cqmqwl3i 137 8 or or CC cord-019043-cqmqwl3i 137 9 fluid fluid JJ cord-019043-cqmqwl3i 137 10 responsiveness responsiveness NN cord-019043-cqmqwl3i 137 11 is be VBZ cord-019043-cqmqwl3i 137 12 not not RB cord-019043-cqmqwl3i 137 13 necessarily necessarily RB cord-019043-cqmqwl3i 137 14 an an DT cord-019043-cqmqwl3i 137 15 indication indication NN cord-019043-cqmqwl3i 137 16 for for IN cord-019043-cqmqwl3i 137 17 a a DT cord-019043-cqmqwl3i 137 18 fluid fluid JJ cord-019043-cqmqwl3i 137 19 challenge challenge NN cord-019043-cqmqwl3i 137 20 . . . cord-019043-cqmqwl3i 138 1 The the DT cord-019043-cqmqwl3i 138 2 distinction distinction NN cord-019043-cqmqwl3i 138 3 is be VBZ cord-019043-cqmqwl3i 138 4 important important JJ cord-019043-cqmqwl3i 138 5 . . . cord-019043-cqmqwl3i 139 1 In in IN cord-019043-cqmqwl3i 139 2 the the DT cord-019043-cqmqwl3i 139 3 context context NN cord-019043-cqmqwl3i 139 4 of of IN cord-019043-cqmqwl3i 139 5 hypovolemia hypovolemia NN cord-019043-cqmqwl3i 139 6 and/or and/or CC cord-019043-cqmqwl3i 139 7 reduced reduced JJ cord-019043-cqmqwl3i 139 8 arterial arterial NN cord-019043-cqmqwl3i 139 9 filling filling NN cord-019043-cqmqwl3i 139 10 , , , cord-019043-cqmqwl3i 139 11 fluid fluid JJ cord-019043-cqmqwl3i 139 12 therapy therapy NN cord-019043-cqmqwl3i 139 13 would would MD cord-019043-cqmqwl3i 139 14 appear appear VB cord-019043-cqmqwl3i 139 15 appropriate appropriate JJ cord-019043-cqmqwl3i 139 16 . . . cord-019043-cqmqwl3i 140 1 However however RB cord-019043-cqmqwl3i 140 2 , , , cord-019043-cqmqwl3i 140 3 there there EX cord-019043-cqmqwl3i 140 4 is be VBZ cord-019043-cqmqwl3i 140 5 no no DT cord-019043-cqmqwl3i 140 6 evidence evidence NN cord-019043-cqmqwl3i 140 7 to to TO cord-019043-cqmqwl3i 140 8 support support VB cord-019043-cqmqwl3i 140 9 a a DT cord-019043-cqmqwl3i 140 10 fluid fluid JJ cord-019043-cqmqwl3i 140 11 challenge challenge NN cord-019043-cqmqwl3i 140 12 in in IN cord-019043-cqmqwl3i 140 13 the the DT cord-019043-cqmqwl3i 140 14 resuscitated resuscitate VBN cord-019043-cqmqwl3i 140 15 patient patient JJ cord-019043-cqmqwl3i 140 16 with with IN cord-019043-cqmqwl3i 140 17 oliguric oliguric JJ cord-019043-cqmqwl3i 140 18 AKI AKI NNP cord-019043-cqmqwl3i 140 19 . . . cord-019043-cqmqwl3i 141 1 While while IN cord-019043-cqmqwl3i 141 2 such such PDT cord-019043-cqmqwl3i 141 3 a a DT cord-019043-cqmqwl3i 141 4 fluid fluid JJ cord-019043-cqmqwl3i 141 5 challenge challenge NN cord-019043-cqmqwl3i 141 6 may may MD cord-019043-cqmqwl3i 141 7 be be VB cord-019043-cqmqwl3i 141 8 intended intend VBN cord-019043-cqmqwl3i 141 9 to to TO cord-019043-cqmqwl3i 141 10 promote promote VB cord-019043-cqmqwl3i 141 11 diuresis diuresis NN cord-019043-cqmqwl3i 141 12 , , , cord-019043-cqmqwl3i 141 13 dilute dilute VB cord-019043-cqmqwl3i 141 14 tubular tubular JJ cord-019043-cqmqwl3i 141 15 toxins toxin NNS cord-019043-cqmqwl3i 141 16 , , , cord-019043-cqmqwl3i 141 17 and and CC cord-019043-cqmqwl3i 141 18 attenuate attenuate VB cord-019043-cqmqwl3i 141 19 tubular tubular JJ cord-019043-cqmqwl3i 141 20 obstruction obstruction NN cord-019043-cqmqwl3i 141 21 from from IN cord-019043-cqmqwl3i 141 22 casts cast NNS cord-019043-cqmqwl3i 141 23 , , , cord-019043-cqmqwl3i 141 24 there there EX cord-019043-cqmqwl3i 141 25 is be VBZ cord-019043-cqmqwl3i 141 26 no no DT cord-019043-cqmqwl3i 141 27 data data NN cord-019043-cqmqwl3i 141 28 to to TO cord-019043-cqmqwl3i 141 29 suggest suggest VB cord-019043-cqmqwl3i 141 30 it -PRON- PRP cord-019043-cqmqwl3i 141 31 attenuates attenuate VBZ cord-019043-cqmqwl3i 141 32 the the DT cord-019043-cqmqwl3i 141 33 severity severity NN cord-019043-cqmqwl3i 141 34 of of IN cord-019043-cqmqwl3i 141 35 AKI AKI NNP cord-019043-cqmqwl3i 141 36 or or CC cord-019043-cqmqwl3i 141 37 improves improve VBZ cord-019043-cqmqwl3i 141 38 clinical clinical JJ cord-019043-cqmqwl3i 141 39 outcome outcome NN cord-019043-cqmqwl3i 141 40 . . . cord-019043-cqmqwl3i 142 1 Instead instead RB cord-019043-cqmqwl3i 142 2 , , , cord-019043-cqmqwl3i 142 3 the the DT cord-019043-cqmqwl3i 142 4 liberal liberal JJ cord-019043-cqmqwl3i 142 5 use use NN cord-019043-cqmqwl3i 142 6 of of IN cord-019043-cqmqwl3i 142 7 fluid fluid JJ cord-019043-cqmqwl3i 142 8 therapy therapy NN cord-019043-cqmqwl3i 142 9 in in IN cord-019043-cqmqwl3i 142 10 these these DT cord-019043-cqmqwl3i 142 11 circumstances circumstance NNS cord-019043-cqmqwl3i 142 12 may may MD cord-019043-cqmqwl3i 142 13 exacerbate exacerbate VB cord-019043-cqmqwl3i 142 14 fluid fluid JJ cord-019043-cqmqwl3i 142 15 overload overload NN cord-019043-cqmqwl3i 142 16 and and CC cord-019043-cqmqwl3i 142 17 lead lead NN cord-019043-cqmqwl3i 142 18 to to IN cord-019043-cqmqwl3i 142 19 harm harm NN cord-019043-cqmqwl3i 142 20 . . . cord-019043-cqmqwl3i 143 1 Fluid fluid JJ cord-019043-cqmqwl3i 143 2 accumulation accumulation NN cord-019043-cqmqwl3i 143 3 can can MD cord-019043-cqmqwl3i 143 4 also also RB cord-019043-cqmqwl3i 143 5 mask mask VB cord-019043-cqmqwl3i 143 6 the the DT cord-019043-cqmqwl3i 143 7 presence presence NN cord-019043-cqmqwl3i 143 8 and and CC cord-019043-cqmqwl3i 143 9 severity severity NN cord-019043-cqmqwl3i 143 10 of of IN cord-019043-cqmqwl3i 143 11 AKI AKI NNP cord-019043-cqmqwl3i 143 12 by by IN cord-019043-cqmqwl3i 143 13 increasing increase VBG cord-019043-cqmqwl3i 143 14 the the DT cord-019043-cqmqwl3i 143 15 total total JJ cord-019043-cqmqwl3i 143 16 body body NN cord-019043-cqmqwl3i 143 17 water water NN cord-019043-cqmqwl3i 143 18 and and CC cord-019043-cqmqwl3i 143 19 hemodiluting hemodiluting NNP cord-019043-cqmqwl3i 143 20 creatinine creatinine NN cord-019043-cqmqwl3i 143 21 . . . cord-019043-cqmqwl3i 144 1 Recent recent JJ cord-019043-cqmqwl3i 144 2 evidence evidence NN cord-019043-cqmqwl3i 144 3 suggests suggest VBZ cord-019043-cqmqwl3i 144 4 that that IN cord-019043-cqmqwl3i 144 5 classifying classify VBG cord-019043-cqmqwl3i 144 6 AKI AKI NNP cord-019043-cqmqwl3i 144 7 after after IN cord-019043-cqmqwl3i 144 8 correcting correct VBG cord-019043-cqmqwl3i 144 9 creatinine creatinine NN cord-019043-cqmqwl3i 144 10 concentration concentration NN cord-019043-cqmqwl3i 144 11 for for IN cord-019043-cqmqwl3i 144 12 the the DT cord-019043-cqmqwl3i 144 13 volume volume NN cord-019043-cqmqwl3i 144 14 of of IN cord-019043-cqmqwl3i 144 15 fluid fluid NN cord-019043-cqmqwl3i 144 16 administered administer VBN cord-019043-cqmqwl3i 144 17 improves improve VBZ cord-019043-cqmqwl3i 144 18 the the DT cord-019043-cqmqwl3i 144 19 ability ability NN cord-019043-cqmqwl3i 144 20 to to TO cord-019043-cqmqwl3i 144 21 classify classify VB cord-019043-cqmqwl3i 144 22 AKI AKI NNP cord-019043-cqmqwl3i 144 23 and and CC cord-019043-cqmqwl3i 144 24 predict predict VB cord-019043-cqmqwl3i 144 25 mortality mortality NN cord-019043-cqmqwl3i 144 26 . . . cord-019043-cqmqwl3i 145 1 Unnecessary unnecessary JJ cord-019043-cqmqwl3i 145 2 fluid fluid JJ cord-019043-cqmqwl3i 145 3 accumulation accumulation NN cord-019043-cqmqwl3i 145 4 and and CC cord-019043-cqmqwl3i 145 5 overload overload NN cord-019043-cqmqwl3i 145 6 are be VBP cord-019043-cqmqwl3i 145 7 associated associate VBN cord-019043-cqmqwl3i 145 8 with with IN cord-019043-cqmqwl3i 145 9 clear clear JJ cord-019043-cqmqwl3i 145 10 increases increase NNS cord-019043-cqmqwl3i 145 11 in in IN cord-019043-cqmqwl3i 145 12 morbidity morbidity NN cord-019043-cqmqwl3i 145 13 , , , cord-019043-cqmqwl3i 145 14 including include VBG cord-019043-cqmqwl3i 145 15 worsening worsen VBG cord-019043-cqmqwl3i 145 16 AKI AKI NNP cord-019043-cqmqwl3i 145 17 and and CC cord-019043-cqmqwl3i 145 18 delayed delay VBN cord-019043-cqmqwl3i 145 19 renal renal JJ cord-019043-cqmqwl3i 145 20 recovery recovery NN cord-019043-cqmqwl3i 145 21 , , , cord-019043-cqmqwl3i 145 22 and and CC cord-019043-cqmqwl3i 145 23 mortality mortality NN cord-019043-cqmqwl3i 145 24 , , , cord-019043-cqmqwl3i 145 25 in in IN cord-019043-cqmqwl3i 145 26 particular particular JJ cord-019043-cqmqwl3i 145 27 in in IN cord-019043-cqmqwl3i 145 28 patients patient NNS cord-019043-cqmqwl3i 145 29 with with IN cord-019043-cqmqwl3i 145 30 compromised compromised JJ cord-019043-cqmqwl3i 145 31 kidney kidney NN cord-019043-cqmqwl3i 145 32 function function NN cord-019043-cqmqwl3i 145 33 across across IN cord-019043-cqmqwl3i 145 34 a a DT cord-019043-cqmqwl3i 145 35 range range NN cord-019043-cqmqwl3i 145 36 of of IN cord-019043-cqmqwl3i 145 37 clinical clinical JJ cord-019043-cqmqwl3i 145 38 settings setting NNS cord-019043-cqmqwl3i 145 39 [ [ -LRB- cord-019043-cqmqwl3i 145 40 5 5 CD cord-019043-cqmqwl3i 145 41 ] ] -RRB- cord-019043-cqmqwl3i 145 42 . . . cord-019043-cqmqwl3i 146 1 Diuretic diuretic JJ cord-019043-cqmqwl3i 146 2 therapy therapy NN cord-019043-cqmqwl3i 146 3 should should MD cord-019043-cqmqwl3i 146 4 be be VB cord-019043-cqmqwl3i 146 5 reserved reserve VBN cord-019043-cqmqwl3i 146 6 for for IN cord-019043-cqmqwl3i 146 7 mitigating mitigate VBG cord-019043-cqmqwl3i 146 8 fluid fluid JJ cord-019043-cqmqwl3i 146 9 overload overload NN cord-019043-cqmqwl3i 146 10 in in IN cord-019043-cqmqwl3i 146 11 responsive responsive JJ cord-019043-cqmqwl3i 146 12 patients patient NNS cord-019043-cqmqwl3i 146 13 rather rather RB cord-019043-cqmqwl3i 146 14 than than IN cord-019043-cqmqwl3i 146 15 for for IN cord-019043-cqmqwl3i 146 16 preventing prevent VBG cord-019043-cqmqwl3i 146 17 AKI AKI NNP cord-019043-cqmqwl3i 146 18 or or CC cord-019043-cqmqwl3i 146 19 promoting promote VBG cord-019043-cqmqwl3i 146 20 recovery recovery NN cord-019043-cqmqwl3i 146 21 of of IN cord-019043-cqmqwl3i 146 22 kidney kidney NN cord-019043-cqmqwl3i 146 23 function function NN cord-019043-cqmqwl3i 146 24 . . . cord-019043-cqmqwl3i 147 1 In in IN cord-019043-cqmqwl3i 147 2 patients patient NNS cord-019043-cqmqwl3i 147 3 whose whose WP$ cord-019043-cqmqwl3i 147 4 fluid fluid JJ cord-019043-cqmqwl3i 147 5 balance balance NN cord-019043-cqmqwl3i 147 6 can can MD cord-019043-cqmqwl3i 147 7 not not RB cord-019043-cqmqwl3i 147 8 be be VB cord-019043-cqmqwl3i 147 9 managed manage VBN cord-019043-cqmqwl3i 147 10 adequately adequately RB cord-019043-cqmqwl3i 147 11 with with IN cord-019043-cqmqwl3i 147 12 conservative conservative JJ cord-019043-cqmqwl3i 147 13 fluid fluid JJ cord-019043-cqmqwl3i 147 14 administration administration NN cord-019043-cqmqwl3i 147 15 or or CC cord-019043-cqmqwl3i 147 16 diuretic diuretic JJ cord-019043-cqmqwl3i 147 17 therapy therapy NN cord-019043-cqmqwl3i 147 18 , , , cord-019043-cqmqwl3i 147 19 RRT rrt NN cord-019043-cqmqwl3i 147 20 should should MD cord-019043-cqmqwl3i 147 21 be be VB cord-019043-cqmqwl3i 147 22 considered consider VBN cord-019043-cqmqwl3i 147 23 . . . cord-019043-cqmqwl3i 148 1 In in IN cord-019043-cqmqwl3i 148 2 addition addition NN cord-019043-cqmqwl3i 148 3 , , , cord-019043-cqmqwl3i 148 4 the the DT cord-019043-cqmqwl3i 148 5 routine routine JJ cord-019043-cqmqwl3i 148 6 practice practice NN cord-019043-cqmqwl3i 148 7 of of IN cord-019043-cqmqwl3i 148 8 providing provide VBG cord-019043-cqmqwl3i 148 9 " " `` cord-019043-cqmqwl3i 148 10 maintenance maintenance NN cord-019043-cqmqwl3i 148 11 " " '' cord-019043-cqmqwl3i 148 12 of of IN cord-019043-cqmqwl3i 148 13 unmeasured unmeasured JJ cord-019043-cqmqwl3i 148 14 fluid fluid JJ cord-019043-cqmqwl3i 148 15 deficits deficit NNS cord-019043-cqmqwl3i 148 16 such such JJ cord-019043-cqmqwl3i 148 17 as as IN cord-019043-cqmqwl3i 148 18 " " `` cord-019043-cqmqwl3i 148 19 third third JJ cord-019043-cqmqwl3i 148 20 space space NN cord-019043-cqmqwl3i 148 21 losses loss NNS cord-019043-cqmqwl3i 148 22 " " '' cord-019043-cqmqwl3i 148 23 for for IN cord-019043-cqmqwl3i 148 24 the the DT cord-019043-cqmqwl3i 148 25 majority majority NN cord-019043-cqmqwl3i 148 26 of of IN cord-019043-cqmqwl3i 148 27 critically critically RB cord-019043-cqmqwl3i 148 28 ill ill JJ cord-019043-cqmqwl3i 148 29 patients patient NNS cord-019043-cqmqwl3i 148 30 is be VBZ cord-019043-cqmqwl3i 148 31 questionable questionable JJ cord-019043-cqmqwl3i 148 32 , , , cord-019043-cqmqwl3i 148 33 in in IN cord-019043-cqmqwl3i 148 34 particular particular JJ cord-019043-cqmqwl3i 148 35 for for IN cord-019043-cqmqwl3i 148 36 those those DT cord-019043-cqmqwl3i 148 37 with with IN cord-019043-cqmqwl3i 148 38 CKD/ ckd/ CD cord-019043-cqmqwl3i 148 39 ESRD ESRD NNP cord-019043-cqmqwl3i 148 40 , , , cord-019043-cqmqwl3i 148 41 and and CC cord-019043-cqmqwl3i 148 42 often often RB cord-019043-cqmqwl3i 148 43 contributes contribute VBZ cord-019043-cqmqwl3i 148 44 unnecessary unnecessary JJ cord-019043-cqmqwl3i 148 45 fluid fluid JJ cord-019043-cqmqwl3i 148 46 accumulation accumulation NN cord-019043-cqmqwl3i 148 47 . . . cord-019043-cqmqwl3i 149 1 In in IN cord-019043-cqmqwl3i 149 2 addition addition NN cord-019043-cqmqwl3i 149 3 , , , cord-019043-cqmqwl3i 149 4 the the DT cord-019043-cqmqwl3i 149 5 types type NNS cord-019043-cqmqwl3i 149 6 of of IN cord-019043-cqmqwl3i 149 7 fluid fluid JJ cord-019043-cqmqwl3i 149 8 administrated administrate VBN cord-019043-cqmqwl3i 149 9 are be VBP cord-019043-cqmqwl3i 149 10 increasingly increasingly RB cord-019043-cqmqwl3i 149 11 recognized recognize VBN cord-019043-cqmqwl3i 149 12 as as IN cord-019043-cqmqwl3i 149 13 having have VBG cord-019043-cqmqwl3i 149 14 dosedependent dosedependent NN cord-019043-cqmqwl3i 149 15 qualitative qualitative JJ cord-019043-cqmqwl3i 149 16 toxic toxic JJ cord-019043-cqmqwl3i 149 17 effects effect NNS cord-019043-cqmqwl3i 149 18 . . . cord-019043-cqmqwl3i 150 1 Colloids colloid NNS cord-019043-cqmqwl3i 150 2 are be VBP cord-019043-cqmqwl3i 150 3 commonly commonly RB cord-019043-cqmqwl3i 150 4 used use VBN cord-019043-cqmqwl3i 150 5 for for IN cord-019043-cqmqwl3i 150 6 acute acute JJ cord-019043-cqmqwl3i 150 7 resuscitation resuscitation NN cord-019043-cqmqwl3i 150 8 in in IN cord-019043-cqmqwl3i 150 9 critically critically RB cord-019043-cqmqwl3i 150 10 ill ill JJ cord-019043-cqmqwl3i 150 11 patients patient NNS cord-019043-cqmqwl3i 150 12 . . . cord-019043-cqmqwl3i 151 1 Synthetic synthetic JJ cord-019043-cqmqwl3i 151 2 colloids colloid NNS cord-019043-cqmqwl3i 151 3 , , , cord-019043-cqmqwl3i 151 4 such such JJ cord-019043-cqmqwl3i 151 5 as as IN cord-019043-cqmqwl3i 151 6 hydroxyethyl hydroxyethyl NN cord-019043-cqmqwl3i 151 7 starch starch NN cord-019043-cqmqwl3i 151 8 ( ( -LRB- cord-019043-cqmqwl3i 151 9 HES HES NNP cord-019043-cqmqwl3i 151 10 ) ) -RRB- cord-019043-cqmqwl3i 151 11 , , , cord-019043-cqmqwl3i 151 12 have have VBP cord-019043-cqmqwl3i 151 13 appeal appeal NN cord-019043-cqmqwl3i 151 14 for for IN cord-019043-cqmqwl3i 151 15 resuscitation resuscitation NN cord-019043-cqmqwl3i 151 16 fluids fluid NNS cord-019043-cqmqwl3i 151 17 based base VBN cord-019043-cqmqwl3i 151 18 on on IN cord-019043-cqmqwl3i 151 19 the the DT cord-019043-cqmqwl3i 151 20 premise premise NN cord-019043-cqmqwl3i 151 21 that that IN cord-019043-cqmqwl3i 151 22 they -PRON- PRP cord-019043-cqmqwl3i 151 23 attenuate attenuate VBP cord-019043-cqmqwl3i 151 24 the the DT cord-019043-cqmqwl3i 151 25 inflammatory inflammatory JJ cord-019043-cqmqwl3i 151 26 response response NN cord-019043-cqmqwl3i 151 27 , , , cord-019043-cqmqwl3i 151 28 mitigate mitigate VB cord-019043-cqmqwl3i 151 29 endothelial endothelial JJ cord-019043-cqmqwl3i 151 30 barrier barrier NN cord-019043-cqmqwl3i 151 31 dysfunction dysfunction NN cord-019043-cqmqwl3i 151 32 , , , cord-019043-cqmqwl3i 151 33 improve improve VB cord-019043-cqmqwl3i 151 34 microcirculatory microcirculatory JJ cord-019043-cqmqwl3i 151 35 flow flow NN cord-019043-cqmqwl3i 151 36 , , , cord-019043-cqmqwl3i 151 37 and and CC cord-019043-cqmqwl3i 151 38 contribute contribute VB cord-019043-cqmqwl3i 151 39 to to IN cord-019043-cqmqwl3i 151 40 more more RBR cord-019043-cqmqwl3i 151 41 rapid rapid JJ cord-019043-cqmqwl3i 151 42 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 151 43 stabilization stabilization NN cord-019043-cqmqwl3i 151 44 ; ; : cord-019043-cqmqwl3i 151 45 however however RB cord-019043-cqmqwl3i 151 46 , , , cord-019043-cqmqwl3i 151 47 accumulated accumulate VBN cord-019043-cqmqwl3i 151 48 data datum NNS cord-019043-cqmqwl3i 151 49 have have VBP cord-019043-cqmqwl3i 151 50 now now RB cord-019043-cqmqwl3i 151 51 suggested suggest VBN cord-019043-cqmqwl3i 151 52 use use NN cord-019043-cqmqwl3i 151 53 of of IN cord-019043-cqmqwl3i 151 54 these these DT cord-019043-cqmqwl3i 151 55 fluids fluid NNS cord-019043-cqmqwl3i 151 56 in in IN cord-019043-cqmqwl3i 151 57 critical critical JJ cord-019043-cqmqwl3i 151 58 illness illness NN cord-019043-cqmqwl3i 151 59 is be VBZ cord-019043-cqmqwl3i 151 60 associated associate VBN cord-019043-cqmqwl3i 151 61 with with IN cord-019043-cqmqwl3i 151 62 dosedependent dosedependent NN cord-019043-cqmqwl3i 151 63 risk risk NN cord-019043-cqmqwl3i 151 64 for for IN cord-019043-cqmqwl3i 151 65 severe severe JJ cord-019043-cqmqwl3i 151 66 AKI AKI NNP cord-019043-cqmqwl3i 151 67 requiring require VBG cord-019043-cqmqwl3i 151 68 RRT rrt NN cord-019043-cqmqwl3i 151 69 , , , cord-019043-cqmqwl3i 151 70 bleeding bleed VBG cord-019043-cqmqwl3i 151 71 complications complication NNS cord-019043-cqmqwl3i 151 72 , , , cord-019043-cqmqwl3i 151 73 and and CC cord-019043-cqmqwl3i 151 74 death death NN cord-019043-cqmqwl3i 151 75 ( ( -LRB- cord-019043-cqmqwl3i 151 76 Box Box NNP cord-019043-cqmqwl3i 151 77 32.2 32.2 CD cord-019043-cqmqwl3i 151 78 ) ) -RRB- cord-019043-cqmqwl3i 151 79 . . . cord-019043-cqmqwl3i 152 1 In in IN cord-019043-cqmqwl3i 152 2 addition addition NN cord-019043-cqmqwl3i 152 3 , , , cord-019043-cqmqwl3i 152 4 these these DT cord-019043-cqmqwl3i 152 5 solutions solution NNS cord-019043-cqmqwl3i 152 6 are be VBP cord-019043-cqmqwl3i 152 7 prohibitively prohibitively RB cord-019043-cqmqwl3i 152 8 more more RBR cord-019043-cqmqwl3i 152 9 Numerous numerous JJ cord-019043-cqmqwl3i 152 10 high high JJ cord-019043-cqmqwl3i 152 11 - - HYPH cord-019043-cqmqwl3i 152 12 quality quality NN cord-019043-cqmqwl3i 152 13 randomized randomized JJ cord-019043-cqmqwl3i 152 14 trials trial NNS cord-019043-cqmqwl3i 152 15 in in IN cord-019043-cqmqwl3i 152 16 adults adult NNS cord-019043-cqmqwl3i 152 17 have have VBP cord-019043-cqmqwl3i 152 18 no no DT cord-019043-cqmqwl3i 152 19 clear clear JJ cord-019043-cqmqwl3i 152 20 evidence evidence NN cord-019043-cqmqwl3i 152 21 of of IN cord-019043-cqmqwl3i 152 22 benefit benefit NN cord-019043-cqmqwl3i 152 23 for for IN cord-019043-cqmqwl3i 152 24 these these DT cord-019043-cqmqwl3i 152 25 therapies therapy NNS cord-019043-cqmqwl3i 152 26 Abbreviations abbreviation NNS cord-019043-cqmqwl3i 152 27 : : : cord-019043-cqmqwl3i 152 28 AKI AKI NNP cord-019043-cqmqwl3i 152 29 acute acute JJ cord-019043-cqmqwl3i 152 30 kidney kidney NN cord-019043-cqmqwl3i 152 31 injury injury NN cord-019043-cqmqwl3i 152 32 , , , cord-019043-cqmqwl3i 152 33 ARDS ARDS NNP cord-019043-cqmqwl3i 152 34 acute acute JJ cord-019043-cqmqwl3i 152 35 respiratory respiratory JJ cord-019043-cqmqwl3i 152 36 distress distress NN cord-019043-cqmqwl3i 152 37 syndrome syndrome NN cord-019043-cqmqwl3i 152 38 , , , cord-019043-cqmqwl3i 152 39 ECMO ecmo NN cord-019043-cqmqwl3i 152 40 extracorporeal extracorporeal JJ cord-019043-cqmqwl3i 152 41 membrane membrane NN cord-019043-cqmqwl3i 152 42 oxygenation oxygenation NN cord-019043-cqmqwl3i 152 43 , , , cord-019043-cqmqwl3i 152 44 HFOV HFOV NNP cord-019043-cqmqwl3i 152 45 high high JJ cord-019043-cqmqwl3i 152 46 - - HYPH cord-019043-cqmqwl3i 152 47 frequency frequency NN cord-019043-cqmqwl3i 152 48 oscillatory oscillatory JJ cord-019043-cqmqwl3i 152 49 ventilation ventilation NN cord-019043-cqmqwl3i 152 50 , , , cord-019043-cqmqwl3i 152 51 iNO iNO NNP cord-019043-cqmqwl3i 152 52 inhaled inhale VBN cord-019043-cqmqwl3i 152 53 nitric nitric NN cord-019043-cqmqwl3i 152 54 oxide oxide NN cord-019043-cqmqwl3i 152 55 , , , cord-019043-cqmqwl3i 152 56 NMB NMB NNP cord-019043-cqmqwl3i 152 57 neuromuscular neuromuscular NN cord-019043-cqmqwl3i 152 58 blockade blockade NN cord-019043-cqmqwl3i 152 59 , , , cord-019043-cqmqwl3i 152 60 PVR PVR NNP cord-019043-cqmqwl3i 152 61 pulmonary pulmonary JJ cord-019043-cqmqwl3i 152 62 vascular vascular JJ cord-019043-cqmqwl3i 152 63 resistance resistance NN cord-019043-cqmqwl3i 152 64 , , , cord-019043-cqmqwl3i 152 65 RM rm NN cord-019043-cqmqwl3i 152 66 recruitment recruitment NN cord-019043-cqmqwl3i 152 67 maneuvers maneuver NNS cord-019043-cqmqwl3i 152 68 , , , cord-019043-cqmqwl3i 152 69 VILI VILI NNP cord-019043-cqmqwl3i 152 70 ventilator ventilator NN cord-019043-cqmqwl3i 152 71 - - HYPH cord-019043-cqmqwl3i 152 72 induced induce VBN cord-019043-cqmqwl3i 152 73 lung lung NN cord-019043-cqmqwl3i 152 74 injury injury NN cord-019043-cqmqwl3i 152 75 expensive expensive JJ cord-019043-cqmqwl3i 152 76 when when WRB cord-019043-cqmqwl3i 152 77 compared compare VBN cord-019043-cqmqwl3i 152 78 with with IN cord-019043-cqmqwl3i 152 79 crystalloids crystalloid NNS cord-019043-cqmqwl3i 152 80 . . . cord-019043-cqmqwl3i 153 1 Albumin albumin NN cord-019043-cqmqwl3i 153 2 is be VBZ cord-019043-cqmqwl3i 153 3 routinely routinely RB cord-019043-cqmqwl3i 153 4 used use VBN cord-019043-cqmqwl3i 153 5 for for IN cord-019043-cqmqwl3i 153 6 resuscitation resuscitation NN cord-019043-cqmqwl3i 153 7 in in IN cord-019043-cqmqwl3i 153 8 liver liver NN cord-019043-cqmqwl3i 153 9 failure failure NN cord-019043-cqmqwl3i 153 10 patients patient NNS cord-019043-cqmqwl3i 153 11 with with IN cord-019043-cqmqwl3i 153 12 spontaneous spontaneous JJ cord-019043-cqmqwl3i 153 13 bacterial bacterial JJ cord-019043-cqmqwl3i 153 14 peritonitis peritonitis NN cord-019043-cqmqwl3i 153 15 for for IN cord-019043-cqmqwl3i 153 16 prevention prevention NN cord-019043-cqmqwl3i 153 17 of of IN cord-019043-cqmqwl3i 153 18 hepatorenal hepatorenal NNP cord-019043-cqmqwl3i 153 19 syndrome syndrome NNP cord-019043-cqmqwl3i 153 20 and and CC cord-019043-cqmqwl3i 153 21 limited limited JJ cord-019043-cqmqwl3i 153 22 clinical clinical JJ cord-019043-cqmqwl3i 153 23 data datum NNS cord-019043-cqmqwl3i 153 24 suggest suggest VBP cord-019043-cqmqwl3i 153 25 albumin albumin NN cord-019043-cqmqwl3i 153 26 may may MD cord-019043-cqmqwl3i 153 27 improve improve VB cord-019043-cqmqwl3i 153 28 outcome outcome NN cord-019043-cqmqwl3i 153 29 in in IN cord-019043-cqmqwl3i 153 30 severe severe JJ cord-019043-cqmqwl3i 153 31 sepsis sepsis NN cord-019043-cqmqwl3i 153 32 . . . cord-019043-cqmqwl3i 154 1 Resuscitation resuscitation NN cord-019043-cqmqwl3i 154 2 with with IN cord-019043-cqmqwl3i 154 3 high high JJ cord-019043-cqmqwl3i 154 4 chloride chloride NN cord-019043-cqmqwl3i 154 5 concentration concentration NN cord-019043-cqmqwl3i 154 6 solutions solution NNS cord-019043-cqmqwl3i 154 7 ( ( -LRB- cord-019043-cqmqwl3i 154 8 i.e. i.e. FW cord-019043-cqmqwl3i 154 9 , , , cord-019043-cqmqwl3i 154 10 0.9 0.9 CD cord-019043-cqmqwl3i 154 11 % % NN cord-019043-cqmqwl3i 154 12 saline saline NN cord-019043-cqmqwl3i 154 13 -strong -strong HYPH cord-019043-cqmqwl3i 154 14 ion ion NN cord-019043-cqmqwl3i 154 15 difference difference NN cord-019043-cqmqwl3i 154 16 : : : cord-019043-cqmqwl3i 154 17 0 0 NFP cord-019043-cqmqwl3i 154 18 mEq mEq NNS cord-019043-cqmqwl3i 154 19 / / SYM cord-019043-cqmqwl3i 154 20 L L NNP cord-019043-cqmqwl3i 154 21 ) ) -RRB- cord-019043-cqmqwl3i 154 22 can can MD cord-019043-cqmqwl3i 154 23 directly directly RB cord-019043-cqmqwl3i 154 24 contribute contribute VB cord-019043-cqmqwl3i 154 25 to to IN cord-019043-cqmqwl3i 154 26 iatrogenic iatrogenic JJ cord-019043-cqmqwl3i 154 27 hyperchloremic hyperchloremic JJ cord-019043-cqmqwl3i 154 28 metabolic metabolic JJ cord-019043-cqmqwl3i 154 29 acidosis acidosis NN cord-019043-cqmqwl3i 154 30 . . . cord-019043-cqmqwl3i 155 1 The the DT cord-019043-cqmqwl3i 155 2 physiologic physiologic JJ cord-019043-cqmqwl3i 155 3 stress stress NN cord-019043-cqmqwl3i 155 4 with with IN cord-019043-cqmqwl3i 155 5 large large JJ cord-019043-cqmqwl3i 155 6 volume volume NN cord-019043-cqmqwl3i 155 7 resuscitation resuscitation NN cord-019043-cqmqwl3i 155 8 of of IN cord-019043-cqmqwl3i 155 9 chloride chloride NN cord-019043-cqmqwl3i 155 10 - - HYPH cord-019043-cqmqwl3i 155 11 rich rich JJ cord-019043-cqmqwl3i 155 12 solutions solution NNS cord-019043-cqmqwl3i 155 13 may may MD cord-019043-cqmqwl3i 155 14 be be VB cord-019043-cqmqwl3i 155 15 less less RBR cord-019043-cqmqwl3i 155 16 tolerated tolerate VBN cord-019043-cqmqwl3i 155 17 in in IN cord-019043-cqmqwl3i 155 18 CKD CKD NNP cord-019043-cqmqwl3i 155 19 patients patient NNS cord-019043-cqmqwl3i 155 20 . . . cord-019043-cqmqwl3i 156 1 Recent recent JJ cord-019043-cqmqwl3i 156 2 data datum NNS cord-019043-cqmqwl3i 156 3 have have VBP cord-019043-cqmqwl3i 156 4 compared compare VBN cord-019043-cqmqwl3i 156 5 resuscitation resuscitation NN cord-019043-cqmqwl3i 156 6 with with IN cord-019043-cqmqwl3i 156 7 saline saline NN cord-019043-cqmqwl3i 156 8 ( ( -LRB- cord-019043-cqmqwl3i 156 9 0.9 0.9 CD cord-019043-cqmqwl3i 156 10 % % NN cord-019043-cqmqwl3i 156 11 ) ) -RRB- cord-019043-cqmqwl3i 156 12 to to IN cord-019043-cqmqwl3i 156 13 balanced balanced JJ cord-019043-cqmqwl3i 156 14 crystalloid crystalloid NN cord-019043-cqmqwl3i 156 15 solutions solution NNS cord-019043-cqmqwl3i 156 16 ( ( -LRB- cord-019043-cqmqwl3i 156 17 i.e. i.e. FW cord-019043-cqmqwl3i 156 18 , , , cord-019043-cqmqwl3i 156 19 Ringer Ringer NNP cord-019043-cqmqwl3i 156 20 's 's POS cord-019043-cqmqwl3i 156 21 lactate lactate NN cord-019043-cqmqwl3i 156 22 , , , cord-019043-cqmqwl3i 156 23 Plasma Plasma NNP cord-019043-cqmqwl3i 156 24 - - HYPH cord-019043-cqmqwl3i 156 25 Lyte Lyte NNP cord-019043-cqmqwl3i 156 26 ) ) -RRB- cord-019043-cqmqwl3i 156 27 . . . cord-019043-cqmqwl3i 157 1 Preferential preferential JJ cord-019043-cqmqwl3i 157 2 use use NN cord-019043-cqmqwl3i 157 3 of of IN cord-019043-cqmqwl3i 157 4 these these DT cord-019043-cqmqwl3i 157 5 balanced balanced JJ cord-019043-cqmqwl3i 157 6 solutions solution NNS cord-019043-cqmqwl3i 157 7 with with IN cord-019043-cqmqwl3i 157 8 a a DT cord-019043-cqmqwl3i 157 9 lower low JJR cord-019043-cqmqwl3i 157 10 " " `` cord-019043-cqmqwl3i 157 11 chloride chloride NN cord-019043-cqmqwl3i 157 12 load load NN cord-019043-cqmqwl3i 157 13 " " '' cord-019043-cqmqwl3i 157 14 that that WDT cord-019043-cqmqwl3i 157 15 more more RBR cord-019043-cqmqwl3i 157 16 closely closely RB cord-019043-cqmqwl3i 157 17 mimic mimic VB cord-019043-cqmqwl3i 157 18 the the DT cord-019043-cqmqwl3i 157 19 chloride chloride NN cord-019043-cqmqwl3i 157 20 content content NN cord-019043-cqmqwl3i 157 21 and and CC cord-019043-cqmqwl3i 157 22 strong strong JJ cord-019043-cqmqwl3i 157 23 ion ion NN cord-019043-cqmqwl3i 157 24 difference difference NN cord-019043-cqmqwl3i 157 25 of of IN cord-019043-cqmqwl3i 157 26 plasma plasma NN cord-019043-cqmqwl3i 157 27 has have VBZ cord-019043-cqmqwl3i 157 28 been be VBN cord-019043-cqmqwl3i 157 29 associated associate VBN cord-019043-cqmqwl3i 157 30 with with IN cord-019043-cqmqwl3i 157 31 fewer few JJR cord-019043-cqmqwl3i 157 32 metabolic metabolic JJ cord-019043-cqmqwl3i 157 33 complications complication NNS cord-019043-cqmqwl3i 157 34 ( ( -LRB- cord-019043-cqmqwl3i 157 35 i.e. i.e. FW cord-019043-cqmqwl3i 157 36 , , , cord-019043-cqmqwl3i 157 37 metabolic metabolic JJ cord-019043-cqmqwl3i 157 38 acidosis acidosis NN cord-019043-cqmqwl3i 157 39 , , , cord-019043-cqmqwl3i 157 40 hyperkalemia hyperkalemia NN cord-019043-cqmqwl3i 157 41 , , , cord-019043-cqmqwl3i 157 42 hypernatremia hypernatremia NN cord-019043-cqmqwl3i 157 43 ) ) -RRB- cord-019043-cqmqwl3i 157 44 , , , cord-019043-cqmqwl3i 157 45 reduced reduce VBN cord-019043-cqmqwl3i 157 46 blood blood NN cord-019043-cqmqwl3i 157 47 product product NN cord-019043-cqmqwl3i 157 48 utilization utilization NN cord-019043-cqmqwl3i 157 49 , , , cord-019043-cqmqwl3i 157 50 reduced reduce VBN cord-019043-cqmqwl3i 157 51 AKI AKI NNP cord-019043-cqmqwl3i 157 52 , , , cord-019043-cqmqwl3i 157 53 and and CC cord-019043-cqmqwl3i 157 54 need need VB cord-019043-cqmqwl3i 157 55 for for IN cord-019043-cqmqwl3i 157 56 RRT rrt NN cord-019043-cqmqwl3i 157 57 and and CC cord-019043-cqmqwl3i 157 58 cost cost NN cord-019043-cqmqwl3i 157 59 savings saving NNS cord-019043-cqmqwl3i 157 60 [ [ -LRB- cord-019043-cqmqwl3i 157 61 6 6 CD cord-019043-cqmqwl3i 157 62 ] ] -RRB- cord-019043-cqmqwl3i 157 63 ( ( -LRB- cord-019043-cqmqwl3i 157 64 Box Box NNP cord-019043-cqmqwl3i 157 65 32.3 32.3 CD cord-019043-cqmqwl3i 157 66 ) ) -RRB- cord-019043-cqmqwl3i 157 67 . . . cord-019043-cqmqwl3i 158 1 There there EX cord-019043-cqmqwl3i 158 2 is be VBZ cord-019043-cqmqwl3i 158 3 uncertain uncertain JJ cord-019043-cqmqwl3i 158 4 benefit benefit NN cord-019043-cqmqwl3i 158 5 for for IN cord-019043-cqmqwl3i 158 6 supplemental supplemental JJ cord-019043-cqmqwl3i 158 7 intravenous intravenous JJ cord-019043-cqmqwl3i 158 8 bicarbonate bicarbonate NN cord-019043-cqmqwl3i 158 9 therapy therapy NN cord-019043-cqmqwl3i 158 10 for for IN cord-019043-cqmqwl3i 158 11 treatment treatment NN cord-019043-cqmqwl3i 158 12 of of IN cord-019043-cqmqwl3i 158 13 metabolic metabolic JJ cord-019043-cqmqwl3i 158 14 acidosis acidosis NN cord-019043-cqmqwl3i 158 15 . . . cord-019043-cqmqwl3i 159 1 Bicarbonate bicarbonate NN cord-019043-cqmqwl3i 159 2 is be VBZ cord-019043-cqmqwl3i 159 3 commonly commonly RB cord-019043-cqmqwl3i 159 4 used use VBN cord-019043-cqmqwl3i 159 5 in in IN cord-019043-cqmqwl3i 159 6 critical critical JJ cord-019043-cqmqwl3i 159 7 illness illness NN cord-019043-cqmqwl3i 159 8 when when WRB cord-019043-cqmqwl3i 159 9 confronted confront VBN cord-019043-cqmqwl3i 159 10 by by IN cord-019043-cqmqwl3i 159 11 severe severe JJ cord-019043-cqmqwl3i 159 12 metabolic metabolic JJ cord-019043-cqmqwl3i 159 13 acidosis acidosis NN cord-019043-cqmqwl3i 159 14 ( ( -LRB- cord-019043-cqmqwl3i 159 15 i.e. i.e. FW cord-019043-cqmqwl3i 159 16 , , , cord-019043-cqmqwl3i 159 17 pH pH NNP cord-019043-cqmqwl3i 159 18 < < XX cord-019043-cqmqwl3i 159 19 7.15 7.15 CD cord-019043-cqmqwl3i 159 20 ) ) -RRB- cord-019043-cqmqwl3i 159 21 ; ; : cord-019043-cqmqwl3i 159 22 however however RB cord-019043-cqmqwl3i 159 23 , , , cord-019043-cqmqwl3i 159 24 its -PRON- PRP$ cord-019043-cqmqwl3i 159 25 use use NN cord-019043-cqmqwl3i 159 26 is be VBZ cord-019043-cqmqwl3i 159 27 guided guide VBN cord-019043-cqmqwl3i 159 28 by by IN cord-019043-cqmqwl3i 159 29 limited limited JJ cord-019043-cqmqwl3i 159 30 clinical clinical JJ cord-019043-cqmqwl3i 159 31 evidence evidence NN cord-019043-cqmqwl3i 159 32 . . . cord-019043-cqmqwl3i 160 1 Bicarbonate bicarbonate NN cord-019043-cqmqwl3i 160 2 supplementation supplementation NN cord-019043-cqmqwl3i 160 3 intended intend VBN cord-019043-cqmqwl3i 160 4 to to TO cord-019043-cqmqwl3i 160 5 treat treat VB cord-019043-cqmqwl3i 160 6 loss loss NN cord-019043-cqmqwl3i 160 7 of of IN cord-019043-cqmqwl3i 160 8 bicarbonate bicarbonate NN cord-019043-cqmqwl3i 160 9 from from IN cord-019043-cqmqwl3i 160 10 the the DT cord-019043-cqmqwl3i 160 11 buffer buffer NN cord-019043-cqmqwl3i 160 12 pool pool NN cord-019043-cqmqwl3i 160 13 ( ( -LRB- cord-019043-cqmqwl3i 160 14 i.e. i.e. FW cord-019043-cqmqwl3i 160 15 , , , cord-019043-cqmqwl3i 160 16 renal renal JJ cord-019043-cqmqwl3i 160 17 tubular tubular JJ cord-019043-cqmqwl3i 160 18 acidosis acidosis NN cord-019043-cqmqwl3i 160 19 ) ) -RRB- cord-019043-cqmqwl3i 160 20 would would MD cord-019043-cqmqwl3i 160 21 appear appear VB cord-019043-cqmqwl3i 160 22 logical logical JJ cord-019043-cqmqwl3i 160 23 ; ; : cord-019043-cqmqwl3i 160 24 however however RB cord-019043-cqmqwl3i 160 25 , , , cord-019043-cqmqwl3i 160 26 its -PRON- PRP$ cord-019043-cqmqwl3i 160 27 use use NN cord-019043-cqmqwl3i 160 28 to to TO cord-019043-cqmqwl3i 160 29 treat treat VB cord-019043-cqmqwl3i 160 30 acidosis acidosis NN cord-019043-cqmqwl3i 160 31 due due IN cord-019043-cqmqwl3i 160 32 to to IN cord-019043-cqmqwl3i 160 33 elevated elevated JJ cord-019043-cqmqwl3i 160 34 lactate lactate NN cord-019043-cqmqwl3i 160 35 has have VBZ cord-019043-cqmqwl3i 160 36 been be VBN cord-019043-cqmqwl3i 160 37 associated associate VBN cord-019043-cqmqwl3i 160 38 with with IN cord-019043-cqmqwl3i 160 39 increased increase VBN cord-019043-cqmqwl3i 160 40 mortality mortality NN cord-019043-cqmqwl3i 160 41 . . . cord-019043-cqmqwl3i 161 1 Bicarbonate Bicarbonate NNP cord-019043-cqmqwl3i 161 2 administration administration NN cord-019043-cqmqwl3i 161 3 ( ( -LRB- cord-019043-cqmqwl3i 161 4 1 1 CD cord-019043-cqmqwl3i 161 5 - - SYM cord-019043-cqmqwl3i 161 6 2 2 CD cord-019043-cqmqwl3i 161 7 mEq mEq NNS cord-019043-cqmqwl3i 161 8 / / SYM cord-019043-cqmqwl3i 161 9 kg kg NNP cord-019043-cqmqwl3i 161 10 ) ) -RRB- cord-019043-cqmqwl3i 161 11 can can MD cord-019043-cqmqwl3i 161 12 transiently transiently RB cord-019043-cqmqwl3i 161 13 increase increase VB cord-019043-cqmqwl3i 161 14 serum serum NN cord-019043-cqmqwl3i 161 15 pH ph NN cord-019043-cqmqwl3i 161 16 and and CC cord-019043-cqmqwl3i 161 17 serum serum NN cord-019043-cqmqwl3i 161 18 bicarbonate bicarbonate NN cord-019043-cqmqwl3i 161 19 ; ; : cord-019043-cqmqwl3i 161 20 however however RB cord-019043-cqmqwl3i 161 21 , , , cord-019043-cqmqwl3i 161 22 it -PRON- PRP cord-019043-cqmqwl3i 161 23 may may MD cord-019043-cqmqwl3i 161 24 precipitate precipitate VB cord-019043-cqmqwl3i 161 25 untoward untoward JJ cord-019043-cqmqwl3i 161 26 adverse adverse JJ cord-019043-cqmqwl3i 161 27 effects effect NNS cord-019043-cqmqwl3i 161 28 including include VBG cord-019043-cqmqwl3i 161 29 worsening worsen VBG cord-019043-cqmqwl3i 161 30 intracellular intracellular JJ cord-019043-cqmqwl3i 161 31 acidosis acidosis NN cord-019043-cqmqwl3i 161 32 , , , cord-019043-cqmqwl3i 161 33 extracellular extracellular JJ cord-019043-cqmqwl3i 161 34 accumulation accumulation NN cord-019043-cqmqwl3i 161 35 of of IN cord-019043-cqmqwl3i 161 36 CO CO NNP cord-019043-cqmqwl3i 161 37 2 2 CD cord-019043-cqmqwl3i 161 38 , , , cord-019043-cqmqwl3i 161 39 Chloride Chloride NNP cord-019043-cqmqwl3i 161 40 is be VBZ cord-019043-cqmqwl3i 161 41 the the DT cord-019043-cqmqwl3i 161 42 predominant predominant JJ cord-019043-cqmqwl3i 161 43 strong strong JJ cord-019043-cqmqwl3i 161 44 anion anion NN cord-019043-cqmqwl3i 161 45 capable capable JJ cord-019043-cqmqwl3i 161 46 of of IN cord-019043-cqmqwl3i 161 47 modifying modify VBG cord-019043-cqmqwl3i 161 48 serum serum NN cord-019043-cqmqwl3i 161 49 pH. ph. NN cord-019043-cqmqwl3i 161 50 Increases increase NNS cord-019043-cqmqwl3i 161 51 in in IN cord-019043-cqmqwl3i 161 52 serum serum NN cord-019043-cqmqwl3i 161 53 chloride chloride NN cord-019043-cqmqwl3i 161 54 concentration concentration NN cord-019043-cqmqwl3i 161 55 ( ( -LRB- cord-019043-cqmqwl3i 161 56 0.9 0.9 CD cord-019043-cqmqwl3i 161 57 % % NN cord-019043-cqmqwl3i 161 58 saline saline NN cord-019043-cqmqwl3i 161 59 administration administration NN cord-019043-cqmqwl3i 161 60 ) ) -RRB- cord-019043-cqmqwl3i 161 61 will will MD cord-019043-cqmqwl3i 161 62 reduce reduce VB cord-019043-cqmqwl3i 161 63 SID SID NNP cord-019043-cqmqwl3i 161 64 and and CC cord-019043-cqmqwl3i 161 65 contribute contribute VB cord-019043-cqmqwl3i 161 66 to to IN cord-019043-cqmqwl3i 161 67 metabolic metabolic JJ cord-019043-cqmqwl3i 161 68 acidosis acidosis NN cord-019043-cqmqwl3i 161 69 with with IN cord-019043-cqmqwl3i 161 70 normal normal JJ cord-019043-cqmqwl3i 161 71 anion anion NN cord-019043-cqmqwl3i 161 72 gap gap NN cord-019043-cqmqwl3i 161 73 . . . cord-019043-cqmqwl3i 162 1 Accumulation accumulation NN cord-019043-cqmqwl3i 162 2 of of IN cord-019043-cqmqwl3i 162 3 organic organic JJ cord-019043-cqmqwl3i 162 4 acids acid NNS cord-019043-cqmqwl3i 162 5 ( ( -LRB- cord-019043-cqmqwl3i 162 6 i.e. i.e. FW cord-019043-cqmqwl3i 162 7 , , , cord-019043-cqmqwl3i 162 8 lactate lactate NN cord-019043-cqmqwl3i 162 9 , , , cord-019043-cqmqwl3i 162 10 keto keto NNP cord-019043-cqmqwl3i 162 11 acids acid NNS cord-019043-cqmqwl3i 162 12 ) ) -RRB- cord-019043-cqmqwl3i 162 13 will will MD cord-019043-cqmqwl3i 162 14 increase increase VB cord-019043-cqmqwl3i 162 15 other other JJ cord-019043-cqmqwl3i 162 16 strong strong JJ cord-019043-cqmqwl3i 162 17 anions anion NNS cord-019043-cqmqwl3i 162 18 and and CC cord-019043-cqmqwl3i 162 19 induce induce VB cord-019043-cqmqwl3i 162 20 metabolic metabolic JJ cord-019043-cqmqwl3i 162 21 acidosis acidosis NN cord-019043-cqmqwl3i 162 22 by by IN cord-019043-cqmqwl3i 162 23 lowering lower VBG cord-019043-cqmqwl3i 162 24 SID SID NNP cord-019043-cqmqwl3i 162 25 with with IN cord-019043-cqmqwl3i 162 26 a a DT cord-019043-cqmqwl3i 162 27 normal normal JJ cord-019043-cqmqwl3i 162 28 serum serum NN cord-019043-cqmqwl3i 162 29 chloride chloride NN cord-019043-cqmqwl3i 162 30 concentration concentration NN cord-019043-cqmqwl3i 162 31 and and CC cord-019043-cqmqwl3i 162 32 elevated elevated JJ cord-019043-cqmqwl3i 162 33 anion anion NN cord-019043-cqmqwl3i 162 34 gap gap NN cord-019043-cqmqwl3i 162 35 . . . cord-019043-cqmqwl3i 163 1 and and CC cord-019043-cqmqwl3i 163 2 hypocalcemia hypocalcemia NN cord-019043-cqmqwl3i 163 3 . . . cord-019043-cqmqwl3i 164 1 The the DT cord-019043-cqmqwl3i 164 2 current current JJ cord-019043-cqmqwl3i 164 3 Surviving survive VBG cord-019043-cqmqwl3i 164 4 Sepsis Sepsis NNP cord-019043-cqmqwl3i 164 5 Guidelines Guidelines NNPS cord-019043-cqmqwl3i 164 6 do do VBP cord-019043-cqmqwl3i 164 7 not not RB cord-019043-cqmqwl3i 164 8 recommend recommend VB cord-019043-cqmqwl3i 164 9 use use NN cord-019043-cqmqwl3i 164 10 of of IN cord-019043-cqmqwl3i 164 11 bicarbonate bicarbonate NN cord-019043-cqmqwl3i 164 12 for for IN cord-019043-cqmqwl3i 164 13 serum serum NN cord-019043-cqmqwl3i 164 14 pH ph NN cord-019043-cqmqwl3i 164 15 > > XX cord-019043-cqmqwl3i 164 16 7.15 7.15 CD cord-019043-cqmqwl3i 164 17 in in IN cord-019043-cqmqwl3i 164 18 patients patient NNS cord-019043-cqmqwl3i 164 19 with with IN cord-019043-cqmqwl3i 164 20 lactic lactic JJ cord-019043-cqmqwl3i 164 21 acidosis acidosis NN cord-019043-cqmqwl3i 164 22 associated associate VBN cord-019043-cqmqwl3i 164 23 with with IN cord-019043-cqmqwl3i 164 24 severe severe JJ cord-019043-cqmqwl3i 164 25 sepsis sepsis NN cord-019043-cqmqwl3i 164 26 . . . cord-019043-cqmqwl3i 165 1 When when WRB cord-019043-cqmqwl3i 165 2 bicarbonate bicarbonate NN cord-019043-cqmqwl3i 165 3 is be VBZ cord-019043-cqmqwl3i 165 4 administered administer VBN cord-019043-cqmqwl3i 165 5 , , , cord-019043-cqmqwl3i 165 6 consideration consideration NN cord-019043-cqmqwl3i 165 7 should should MD cord-019043-cqmqwl3i 165 8 be be VB cord-019043-cqmqwl3i 165 9 given give VBN cord-019043-cqmqwl3i 165 10 for for IN cord-019043-cqmqwl3i 165 11 a a DT cord-019043-cqmqwl3i 165 12 slow slow JJ cord-019043-cqmqwl3i 165 13 infusion infusion NN cord-019043-cqmqwl3i 165 14 , , , cord-019043-cqmqwl3i 165 15 allowance allowance NN cord-019043-cqmqwl3i 165 16 for for IN cord-019043-cqmqwl3i 165 17 adequate adequate JJ cord-019043-cqmqwl3i 165 18 CO CO NNP cord-019043-cqmqwl3i 165 19 2 2 CD cord-019043-cqmqwl3i 165 20 removal removal NN cord-019043-cqmqwl3i 165 21 , , , cord-019043-cqmqwl3i 165 22 and and CC cord-019043-cqmqwl3i 165 23 correction correction NN cord-019043-cqmqwl3i 165 24 of of IN cord-019043-cqmqwl3i 165 25 hypocalcemia hypocalcemia NN cord-019043-cqmqwl3i 165 26 along along IN cord-019043-cqmqwl3i 165 27 with with IN cord-019043-cqmqwl3i 165 28 reversal reversal NN cord-019043-cqmqwl3i 165 29 of of IN cord-019043-cqmqwl3i 165 30 the the DT cord-019043-cqmqwl3i 165 31 underlying underlying JJ cord-019043-cqmqwl3i 165 32 contributing contribute VBG cord-019043-cqmqwl3i 165 33 factor factor NN cord-019043-cqmqwl3i 165 34 for for IN cord-019043-cqmqwl3i 165 35 the the DT cord-019043-cqmqwl3i 165 36 acidosis acidosis NN cord-019043-cqmqwl3i 165 37 . . . cord-019043-cqmqwl3i 166 1 Malnutrition malnutrition NN cord-019043-cqmqwl3i 166 2 is be VBZ cord-019043-cqmqwl3i 166 3 an an DT cord-019043-cqmqwl3i 166 4 important important JJ cord-019043-cqmqwl3i 166 5 contributor contributor NN cord-019043-cqmqwl3i 166 6 to to IN cord-019043-cqmqwl3i 166 7 increased increase VBN cord-019043-cqmqwl3i 166 8 morbidity morbidity NN cord-019043-cqmqwl3i 166 9 and and CC cord-019043-cqmqwl3i 166 10 mortality mortality NN cord-019043-cqmqwl3i 166 11 in in IN cord-019043-cqmqwl3i 166 12 critical critical JJ cord-019043-cqmqwl3i 166 13 illness illness NN cord-019043-cqmqwl3i 166 14 . . . cord-019043-cqmqwl3i 167 1 Critically critically RB cord-019043-cqmqwl3i 167 2 ill ill JJ cord-019043-cqmqwl3i 167 3 patients patient NNS cord-019043-cqmqwl3i 167 4 , , , cord-019043-cqmqwl3i 167 5 in in IN cord-019043-cqmqwl3i 167 6 particular particular JJ cord-019043-cqmqwl3i 167 7 those those DT cord-019043-cqmqwl3i 167 8 with with IN cord-019043-cqmqwl3i 167 9 premorbid premorbid NN cord-019043-cqmqwl3i 167 10 comorbid comorbid NN cord-019043-cqmqwl3i 167 11 disease disease NN cord-019043-cqmqwl3i 167 12 such such JJ cord-019043-cqmqwl3i 167 13 as as IN cord-019043-cqmqwl3i 167 14 CKD CKD NNP cord-019043-cqmqwl3i 167 15 and and CC cord-019043-cqmqwl3i 167 16 those those DT cord-019043-cqmqwl3i 167 17 with with IN cord-019043-cqmqwl3i 167 18 acute acute JJ cord-019043-cqmqwl3i 167 19 organ organ NN cord-019043-cqmqwl3i 167 20 dysfunction dysfunction NN cord-019043-cqmqwl3i 167 21 such such JJ cord-019043-cqmqwl3i 167 22 as as IN cord-019043-cqmqwl3i 167 23 AKI AKI NNP cord-019043-cqmqwl3i 167 24 , , , cord-019043-cqmqwl3i 167 25 can can MD cord-019043-cqmqwl3i 167 26 often often RB cord-019043-cqmqwl3i 167 27 present present VB cord-019043-cqmqwl3i 167 28 nutritionally nutritionally RB cord-019043-cqmqwl3i 167 29 at at IN cord-019043-cqmqwl3i 167 30 risk risk NN cord-019043-cqmqwl3i 167 31 or or CC cord-019043-cqmqwl3i 167 32 overtly overtly RB cord-019043-cqmqwl3i 167 33 malnourished malnourished JJ cord-019043-cqmqwl3i 167 34 at at IN cord-019043-cqmqwl3i 167 35 the the DT cord-019043-cqmqwl3i 167 36 time time NN cord-019043-cqmqwl3i 167 37 of of IN cord-019043-cqmqwl3i 167 38 admission admission NN cord-019043-cqmqwl3i 167 39 . . . cord-019043-cqmqwl3i 168 1 Critical critical JJ cord-019043-cqmqwl3i 168 2 illness illness NN cord-019043-cqmqwl3i 168 3 is be VBZ cord-019043-cqmqwl3i 168 4 a a DT cord-019043-cqmqwl3i 168 5 physiologic physiologic JJ cord-019043-cqmqwl3i 168 6 state state NN cord-019043-cqmqwl3i 168 7 characterized characterize VBN cord-019043-cqmqwl3i 168 8 by by IN cord-019043-cqmqwl3i 168 9 widespread widespread JJ cord-019043-cqmqwl3i 168 10 system system NN cord-019043-cqmqwl3i 168 11 inflammation inflammation NN cord-019043-cqmqwl3i 168 12 , , , cord-019043-cqmqwl3i 168 13 metabolic metabolic JJ cord-019043-cqmqwl3i 168 14 derangement derangement NN cord-019043-cqmqwl3i 168 15 , , , cord-019043-cqmqwl3i 168 16 and and CC cord-019043-cqmqwl3i 168 17 catabolism catabolism NN cord-019043-cqmqwl3i 168 18 . . . cord-019043-cqmqwl3i 169 1 In in IN cord-019043-cqmqwl3i 169 2 these these DT cord-019043-cqmqwl3i 169 3 circumstances circumstance NNS cord-019043-cqmqwl3i 169 4 , , , cord-019043-cqmqwl3i 169 5 critically critically RB cord-019043-cqmqwl3i 169 6 ill ill JJ cord-019043-cqmqwl3i 169 7 patients patient NNS cord-019043-cqmqwl3i 169 8 , , , cord-019043-cqmqwl3i 169 9 in in IN cord-019043-cqmqwl3i 169 10 particular particular JJ cord-019043-cqmqwl3i 169 11 those those DT cord-019043-cqmqwl3i 169 12 already already RB cord-019043-cqmqwl3i 169 13 malnourished malnourished JJ cord-019043-cqmqwl3i 169 14 , , , cord-019043-cqmqwl3i 169 15 may may MD cord-019043-cqmqwl3i 169 16 be be VB cord-019043-cqmqwl3i 169 17 unable unable JJ cord-019043-cqmqwl3i 169 18 to to TO cord-019043-cqmqwl3i 169 19 adequately adequately RB cord-019043-cqmqwl3i 169 20 absorb absorb VB cord-019043-cqmqwl3i 169 21 or or CC cord-019043-cqmqwl3i 169 22 utilize utilize VB cord-019043-cqmqwl3i 169 23 nutrients nutrient NNS cord-019043-cqmqwl3i 169 24 . . . cord-019043-cqmqwl3i 170 1 This this DT cord-019043-cqmqwl3i 170 2 may may MD cord-019043-cqmqwl3i 170 3 be be VB cord-019043-cqmqwl3i 170 4 further further RB cord-019043-cqmqwl3i 170 5 compounded compound VBN cord-019043-cqmqwl3i 170 6 by by IN cord-019043-cqmqwl3i 170 7 added add VBN cord-019043-cqmqwl3i 170 8 clearance clearance NN cord-019043-cqmqwl3i 170 9 of of IN cord-019043-cqmqwl3i 170 10 nutrients nutrient NNS cord-019043-cqmqwl3i 170 11 during during IN cord-019043-cqmqwl3i 170 12 RRT RRT NNP cord-019043-cqmqwl3i 170 13 . . . cord-019043-cqmqwl3i 171 1 The the DT cord-019043-cqmqwl3i 171 2 goal goal NN cord-019043-cqmqwl3i 171 3 in in IN cord-019043-cqmqwl3i 171 4 critical critical JJ cord-019043-cqmqwl3i 171 5 illness illness NN cord-019043-cqmqwl3i 171 6 is be VBZ cord-019043-cqmqwl3i 171 7 to to TO cord-019043-cqmqwl3i 171 8 provide provide VB cord-019043-cqmqwl3i 171 9 sufficient sufficient JJ cord-019043-cqmqwl3i 171 10 nutritional nutritional JJ cord-019043-cqmqwl3i 171 11 support support NN cord-019043-cqmqwl3i 171 12 as as IN cord-019043-cqmqwl3i 171 13 to to TO cord-019043-cqmqwl3i 171 14 maintain maintain VB cord-019043-cqmqwl3i 171 15 homeostatic homeostatic JJ cord-019043-cqmqwl3i 171 16 and and CC cord-019043-cqmqwl3i 171 17 metabolic metabolic JJ cord-019043-cqmqwl3i 171 18 needs need NNS cord-019043-cqmqwl3i 171 19 without without IN cord-019043-cqmqwl3i 171 20 precipitating precipitate VBG cord-019043-cqmqwl3i 171 21 complications complication NNS cord-019043-cqmqwl3i 171 22 . . . cord-019043-cqmqwl3i 172 1 Importantly importantly RB cord-019043-cqmqwl3i 172 2 , , , cord-019043-cqmqwl3i 172 3 determination determination NN cord-019043-cqmqwl3i 172 4 of of IN cord-019043-cqmqwl3i 172 5 the the DT cord-019043-cqmqwl3i 172 6 optimal optimal JJ cord-019043-cqmqwl3i 172 7 caloric caloric JJ cord-019043-cqmqwl3i 172 8 intake intake NN cord-019043-cqmqwl3i 172 9 for for IN cord-019043-cqmqwl3i 172 10 critically critically RB cord-019043-cqmqwl3i 172 11 ill ill JJ cord-019043-cqmqwl3i 172 12 patients patient NNS cord-019043-cqmqwl3i 172 13 ideally ideally RB cord-019043-cqmqwl3i 172 14 should should MD cord-019043-cqmqwl3i 172 15 involve involve VB cord-019043-cqmqwl3i 172 16 the the DT cord-019043-cqmqwl3i 172 17 interdisciplinary interdisciplinary JJ cord-019043-cqmqwl3i 172 18 contributions contribution NNS cord-019043-cqmqwl3i 172 19 of of IN cord-019043-cqmqwl3i 172 20 a a DT cord-019043-cqmqwl3i 172 21 dietician dietician NN cord-019043-cqmqwl3i 172 22 . . . cord-019043-cqmqwl3i 173 1 Dieticians dietician NNS cord-019043-cqmqwl3i 173 2 can can MD cord-019043-cqmqwl3i 173 3 assist assist VB cord-019043-cqmqwl3i 173 4 with with IN cord-019043-cqmqwl3i 173 5 ensuring ensure VBG cord-019043-cqmqwl3i 173 6 optimal optimal JJ cord-019043-cqmqwl3i 173 7 nutritional nutritional JJ cord-019043-cqmqwl3i 173 8 prescription prescription NN cord-019043-cqmqwl3i 173 9 for for IN cord-019043-cqmqwl3i 173 10 critically critically RB cord-019043-cqmqwl3i 173 11 ill ill JJ cord-019043-cqmqwl3i 173 12 patients patient NNS cord-019043-cqmqwl3i 173 13 with with IN cord-019043-cqmqwl3i 173 14 AKI AKI NNP cord-019043-cqmqwl3i 173 15 or or CC cord-019043-cqmqwl3i 173 16 CKD CKD NNP cord-019043-cqmqwl3i 173 17 / / SYM cord-019043-cqmqwl3i 173 18 ESKD ESKD NNP cord-019043-cqmqwl3i 173 19 as as IN cord-019043-cqmqwl3i 173 20 their -PRON- PRP$ cord-019043-cqmqwl3i 173 21 course course NN cord-019043-cqmqwl3i 173 22 and and CC cord-019043-cqmqwl3i 173 23 therapies therapy NNS cord-019043-cqmqwl3i 173 24 evolve evolve VBP cord-019043-cqmqwl3i 173 25 ( ( -LRB- cord-019043-cqmqwl3i 173 26 i.e. i.e. FW cord-019043-cqmqwl3i 173 27 , , , cord-019043-cqmqwl3i 173 28 resolving resolve VBG cord-019043-cqmqwl3i 173 29 organ organ NN cord-019043-cqmqwl3i 173 30 dysfunction dysfunction NN cord-019043-cqmqwl3i 173 31 , , , cord-019043-cqmqwl3i 173 32 recovering recover VBG cord-019043-cqmqwl3i 173 33 kidney kidney NN cord-019043-cqmqwl3i 173 34 function function NN cord-019043-cqmqwl3i 173 35 , , , cord-019043-cqmqwl3i 173 36 transition transition NN cord-019043-cqmqwl3i 173 37 from from IN cord-019043-cqmqwl3i 173 38 continuous continuous JJ cord-019043-cqmqwl3i 173 39 to to IN cord-019043-cqmqwl3i 173 40 intermittent intermittent JJ cord-019043-cqmqwl3i 173 41 RRT RRT NNP cord-019043-cqmqwl3i 173 42 ) ) -RRB- cord-019043-cqmqwl3i 173 43 . . . cord-019043-cqmqwl3i 174 1 Early early JJ cord-019043-cqmqwl3i 174 2 nutritional nutritional JJ cord-019043-cqmqwl3i 174 3 support support NN cord-019043-cqmqwl3i 174 4 in in IN cord-019043-cqmqwl3i 174 5 critical critical JJ cord-019043-cqmqwl3i 174 6 illness illness NN cord-019043-cqmqwl3i 174 7 will will MD cord-019043-cqmqwl3i 174 8 not not RB cord-019043-cqmqwl3i 174 9 be be VB cord-019043-cqmqwl3i 174 10 significantly significantly RB cord-019043-cqmqwl3i 174 11 modified modify VBN cord-019043-cqmqwl3i 174 12 by by IN cord-019043-cqmqwl3i 174 13 the the DT cord-019043-cqmqwl3i 174 14 presence presence NN cord-019043-cqmqwl3i 174 15 of of IN cord-019043-cqmqwl3i 174 16 CKD CKD NNP cord-019043-cqmqwl3i 174 17 ; ; : cord-019043-cqmqwl3i 174 18 however however RB cord-019043-cqmqwl3i 174 19 , , , cord-019043-cqmqwl3i 174 20 in in IN cord-019043-cqmqwl3i 174 21 patients patient NNS cord-019043-cqmqwl3i 174 22 with with IN cord-019043-cqmqwl3i 174 23 advanced advanced JJ cord-019043-cqmqwl3i 174 24 CKD CKD NNP cord-019043-cqmqwl3i 174 25 or or CC cord-019043-cqmqwl3i 174 26 ESRD ESRD NNP cord-019043-cqmqwl3i 174 27 not not RB cord-019043-cqmqwl3i 174 28 supported support VBN cord-019043-cqmqwl3i 174 29 with with IN cord-019043-cqmqwl3i 174 30 RRT RRT NNP cord-019043-cqmqwl3i 174 31 , , , cord-019043-cqmqwl3i 174 32 specialized specialized JJ cord-019043-cqmqwl3i 174 33 enteric enteric JJ cord-019043-cqmqwl3i 174 34 formulas formula NNS cord-019043-cqmqwl3i 174 35 are be VBP cord-019043-cqmqwl3i 174 36 available available JJ cord-019043-cqmqwl3i 174 37 that that WDT cord-019043-cqmqwl3i 174 38 are be VBP cord-019043-cqmqwl3i 174 39 more more RBR cord-019043-cqmqwl3i 174 40 caloric caloric JJ cord-019043-cqmqwl3i 174 41 dense dense JJ cord-019043-cqmqwl3i 174 42 ( ( -LRB- cord-019043-cqmqwl3i 174 43 2 2 CD cord-019043-cqmqwl3i 174 44 kcal kcal NNP cord-019043-cqmqwl3i 174 45 / / SYM cord-019043-cqmqwl3i 174 46 mL mL NNP cord-019043-cqmqwl3i 174 47 ) ) -RRB- cord-019043-cqmqwl3i 174 48 , , , cord-019043-cqmqwl3i 174 49 low low JJ cord-019043-cqmqwl3i 174 50 in in IN cord-019043-cqmqwl3i 174 51 electrolytes electrolyte NNS cord-019043-cqmqwl3i 174 52 ( ( -LRB- cord-019043-cqmqwl3i 174 53 i.e. i.e. FW cord-019043-cqmqwl3i 174 54 , , , cord-019043-cqmqwl3i 174 55 K K NNP cord-019043-cqmqwl3i 174 56 + + XX cord-019043-cqmqwl3i 174 57 , , , cord-019043-cqmqwl3i 174 58 PO PO NNP cord-019043-cqmqwl3i 174 59 4 4 CD cord-019043-cqmqwl3i 174 60 − − NNP cord-019043-cqmqwl3i 174 61 , , , cord-019043-cqmqwl3i 174 62 Mg Mg NNP cord-019043-cqmqwl3i 174 63 + + CC cord-019043-cqmqwl3i 174 64 ) ) -RRB- cord-019043-cqmqwl3i 174 65 , , , cord-019043-cqmqwl3i 174 66 and and CC cord-019043-cqmqwl3i 174 67 fluid fluid NN cord-019043-cqmqwl3i 174 68 restricted restrict VBN cord-019043-cqmqwl3i 174 69 . . . cord-019043-cqmqwl3i 175 1 The the DT cord-019043-cqmqwl3i 175 2 intent intent NN cord-019043-cqmqwl3i 175 3 of of IN cord-019043-cqmqwl3i 175 4 these these DT cord-019043-cqmqwl3i 175 5 specialized specialize VBN cord-019043-cqmqwl3i 175 6 formulations formulation NNS cord-019043-cqmqwl3i 175 7 is be VBZ cord-019043-cqmqwl3i 175 8 to to TO cord-019043-cqmqwl3i 175 9 pro pro JJ cord-019043-cqmqwl3i 175 10 - - JJ cord-019043-cqmqwl3i 175 11 vide vide JJ cord-019043-cqmqwl3i 175 12 adequate adequate JJ cord-019043-cqmqwl3i 175 13 nutritional nutritional JJ cord-019043-cqmqwl3i 175 14 support support NN cord-019043-cqmqwl3i 175 15 while while IN cord-019043-cqmqwl3i 175 16 mitigating mitigate VBG cord-019043-cqmqwl3i 175 17 the the DT cord-019043-cqmqwl3i 175 18 development development NN cord-019043-cqmqwl3i 175 19 of of IN cord-019043-cqmqwl3i 175 20 metabolic metabolic JJ cord-019043-cqmqwl3i 175 21 complications complication NNS cord-019043-cqmqwl3i 175 22 or or CC cord-019043-cqmqwl3i 175 23 unnecessary unnecessary JJ cord-019043-cqmqwl3i 175 24 fluid fluid JJ cord-019043-cqmqwl3i 175 25 accumulation accumulation NN cord-019043-cqmqwl3i 175 26 in in IN cord-019043-cqmqwl3i 175 27 patients patient NNS cord-019043-cqmqwl3i 175 28 with with IN cord-019043-cqmqwl3i 175 29 reduced reduce VBN cord-019043-cqmqwl3i 175 30 GFR GFR NNP cord-019043-cqmqwl3i 175 31 . . . cord-019043-cqmqwl3i 176 1 In in IN cord-019043-cqmqwl3i 176 2 patients patient NNS cord-019043-cqmqwl3i 176 3 with with IN cord-019043-cqmqwl3i 176 4 AKI AKI NNP cord-019043-cqmqwl3i 176 5 , , , cord-019043-cqmqwl3i 176 6 one one CD cord-019043-cqmqwl3i 176 7 of of IN cord-019043-cqmqwl3i 176 8 the the DT cord-019043-cqmqwl3i 176 9 few few JJ cord-019043-cqmqwl3i 176 10 interventions intervention NNS cord-019043-cqmqwl3i 176 11 proven prove VBN cord-019043-cqmqwl3i 176 12 to to TO cord-019043-cqmqwl3i 176 13 improve improve VB cord-019043-cqmqwl3i 176 14 renal renal JJ cord-019043-cqmqwl3i 176 15 recovery recovery NN cord-019043-cqmqwl3i 176 16 is be VBZ cord-019043-cqmqwl3i 176 17 delivery delivery NN cord-019043-cqmqwl3i 176 18 of of IN cord-019043-cqmqwl3i 176 19 adequate adequate JJ cord-019043-cqmqwl3i 176 20 nutritional nutritional JJ cord-019043-cqmqwl3i 176 21 support support NN cord-019043-cqmqwl3i 176 22 , , , cord-019043-cqmqwl3i 176 23 and and CC cord-019043-cqmqwl3i 176 24 therefore therefore RB cord-019043-cqmqwl3i 176 25 , , , cord-019043-cqmqwl3i 176 26 more more JJR cord-019043-cqmqwl3i 176 27 recent recent JJ cord-019043-cqmqwl3i 176 28 guidelines guideline NNS cord-019043-cqmqwl3i 176 29 discourage discourage VBP cord-019043-cqmqwl3i 176 30 protein protein NN cord-019043-cqmqwl3i 176 31 restriction restriction NN cord-019043-cqmqwl3i 176 32 in in IN cord-019043-cqmqwl3i 176 33 critically critically RB cord-019043-cqmqwl3i 176 34 ill ill JJ cord-019043-cqmqwl3i 176 35 patients patient NNS cord-019043-cqmqwl3i 176 36 with with IN cord-019043-cqmqwl3i 176 37 AKI AKI NNP cord-019043-cqmqwl3i 176 38 and and CC cord-019043-cqmqwl3i 176 39 supplement supplement NN cord-019043-cqmqwl3i 176 40 protein protein NN cord-019043-cqmqwl3i 176 41 further far RBR cord-019043-cqmqwl3i 176 42 in in IN cord-019043-cqmqwl3i 176 43 patients patient NNS cord-019043-cqmqwl3i 176 44 receiving receive VBG cord-019043-cqmqwl3i 176 45 RRT RRT NNP cord-019043-cqmqwl3i 176 46 [ [ -LRB- cord-019043-cqmqwl3i 176 47 8 8 CD cord-019043-cqmqwl3i 176 48 ] ] -RRB- cord-019043-cqmqwl3i 176 49 . . . cord-019043-cqmqwl3i 177 1 The the DT cord-019043-cqmqwl3i 177 2 preferred preferred JJ cord-019043-cqmqwl3i 177 3 method method NN cord-019043-cqmqwl3i 177 4 for for IN cord-019043-cqmqwl3i 177 5 delivery delivery NN cord-019043-cqmqwl3i 177 6 of of IN cord-019043-cqmqwl3i 177 7 nutritional nutritional JJ cord-019043-cqmqwl3i 177 8 support support NN cord-019043-cqmqwl3i 177 9 is be VBZ cord-019043-cqmqwl3i 177 10 by by IN cord-019043-cqmqwl3i 177 11 the the DT cord-019043-cqmqwl3i 177 12 enteric enteric JJ cord-019043-cqmqwl3i 177 13 route route NN cord-019043-cqmqwl3i 177 14 . . . cord-019043-cqmqwl3i 178 1 This this DT cord-019043-cqmqwl3i 178 2 should should MD cord-019043-cqmqwl3i 178 3 be be VB cord-019043-cqmqwl3i 178 4 started start VBN cord-019043-cqmqwl3i 178 5 early early RB cord-019043-cqmqwl3i 178 6 after after IN cord-019043-cqmqwl3i 178 7 ICU ICU NNP cord-019043-cqmqwl3i 178 8 admission admission NN cord-019043-cqmqwl3i 178 9 ( ( -LRB- cord-019043-cqmqwl3i 178 10 within within IN cord-019043-cqmqwl3i 178 11 24 24 CD cord-019043-cqmqwl3i 178 12 - - SYM cord-019043-cqmqwl3i 178 13 48 48 CD cord-019043-cqmqwl3i 178 14 h h NN cord-019043-cqmqwl3i 178 15 ) ) -RRB- cord-019043-cqmqwl3i 178 16 . . . cord-019043-cqmqwl3i 179 1 The the DT cord-019043-cqmqwl3i 179 2 rationale rationale NN cord-019043-cqmqwl3i 179 3 for for IN cord-019043-cqmqwl3i 179 4 prioritizing prioritize VBG cord-019043-cqmqwl3i 179 5 enteric enteric JJ cord-019043-cqmqwl3i 179 6 delivery delivery NN cord-019043-cqmqwl3i 179 7 of of IN cord-019043-cqmqwl3i 179 8 nutrition nutrition NN cord-019043-cqmqwl3i 179 9 ( ( -LRB- cord-019043-cqmqwl3i 179 10 EN EN NNP cord-019043-cqmqwl3i 179 11 ) ) -RRB- cord-019043-cqmqwl3i 179 12 is be VBZ cord-019043-cqmqwl3i 179 13 based base VBN cord-019043-cqmqwl3i 179 14 on on IN cord-019043-cqmqwl3i 179 15 the the DT cord-019043-cqmqwl3i 179 16 premise premise NN cord-019043-cqmqwl3i 179 17 that that IN cord-019043-cqmqwl3i 179 18 it -PRON- PRP cord-019043-cqmqwl3i 179 19 will will MD cord-019043-cqmqwl3i 179 20 preserve preserve VB cord-019043-cqmqwl3i 179 21 gut gut NN cord-019043-cqmqwl3i 179 22 mucosal mucosal JJ cord-019043-cqmqwl3i 179 23 integrity integrity NN cord-019043-cqmqwl3i 179 24 , , , cord-019043-cqmqwl3i 179 25 reduce reduce VB cord-019043-cqmqwl3i 179 26 bacterial bacterial JJ cord-019043-cqmqwl3i 179 27 and and CC cord-019043-cqmqwl3i 179 28 endotoxin endotoxin NN cord-019043-cqmqwl3i 179 29 translocation translocation NN cord-019043-cqmqwl3i 179 30 , , , cord-019043-cqmqwl3i 179 31 and and CC cord-019043-cqmqwl3i 179 32 reduce reduce VB cord-019043-cqmqwl3i 179 33 the the DT cord-019043-cqmqwl3i 179 34 risk risk NN cord-019043-cqmqwl3i 179 35 of of IN cord-019043-cqmqwl3i 179 36 gastrointestinal gastrointestinal JJ cord-019043-cqmqwl3i 179 37 bleeding bleeding NN cord-019043-cqmqwl3i 179 38 . . . cord-019043-cqmqwl3i 180 1 However however RB cord-019043-cqmqwl3i 180 2 , , , cord-019043-cqmqwl3i 180 3 critical critical JJ cord-019043-cqmqwl3i 180 4 illness illness NN cord-019043-cqmqwl3i 180 5 , , , cord-019043-cqmqwl3i 180 6 coupled couple VBN cord-019043-cqmqwl3i 180 7 with with IN cord-019043-cqmqwl3i 180 8 baseline baseline JJ cord-019043-cqmqwl3i 180 9 susceptibilities susceptibility NNS cord-019043-cqmqwl3i 180 10 ( ( -LRB- cord-019043-cqmqwl3i 180 11 i.e. i.e. FW cord-019043-cqmqwl3i 180 12 , , , cord-019043-cqmqwl3i 180 13 diabetes diabetes NN cord-019043-cqmqwl3i 180 14 mellitus mellitus NN cord-019043-cqmqwl3i 180 15 ) ) -RRB- cord-019043-cqmqwl3i 180 16 , , , cord-019043-cqmqwl3i 180 17 may may MD cord-019043-cqmqwl3i 180 18 be be VB cord-019043-cqmqwl3i 180 19 associated associate VBN cord-019043-cqmqwl3i 180 20 with with IN cord-019043-cqmqwl3i 180 21 enteric enteric JJ cord-019043-cqmqwl3i 180 22 feeding feeding NN cord-019043-cqmqwl3i 180 23 intolerance intolerance NN cord-019043-cqmqwl3i 180 24 from from IN cord-019043-cqmqwl3i 180 25 gut gut NN cord-019043-cqmqwl3i 180 26 dysmotility dysmotility NN cord-019043-cqmqwl3i 180 27 ( ( -LRB- cord-019043-cqmqwl3i 180 28 i.e. i.e. FW cord-019043-cqmqwl3i 180 29 , , , cord-019043-cqmqwl3i 180 30 medications medication NNS cord-019043-cqmqwl3i 180 31 , , , cord-019043-cqmqwl3i 180 32 electrolyte electrolyte NN cord-019043-cqmqwl3i 180 33 disorders disorder NNS cord-019043-cqmqwl3i 180 34 , , , cord-019043-cqmqwl3i 180 35 comorbid comorbid NN cord-019043-cqmqwl3i 180 36 disease disease NN cord-019043-cqmqwl3i 180 37 ) ) -RRB- cord-019043-cqmqwl3i 180 38 and and CC cord-019043-cqmqwl3i 180 39 suboptimal suboptimal JJ cord-019043-cqmqwl3i 180 40 absorption absorption NN cord-019043-cqmqwl3i 180 41 ( ( -LRB- cord-019043-cqmqwl3i 180 42 i.e. i.e. FW cord-019043-cqmqwl3i 180 43 , , , cord-019043-cqmqwl3i 180 44 gut gut VB cord-019043-cqmqwl3i 180 45 wall wall NN cord-019043-cqmqwl3i 180 46 edema edema NN cord-019043-cqmqwl3i 180 47 ) ) -RRB- cord-019043-cqmqwl3i 180 48 . . . cord-019043-cqmqwl3i 181 1 Two two CD cord-019043-cqmqwl3i 181 2 recent recent JJ cord-019043-cqmqwl3i 181 3 trials trial NNS cord-019043-cqmqwl3i 181 4 in in IN cord-019043-cqmqwl3i 181 5 critically critically RB cord-019043-cqmqwl3i 181 6 ill ill JJ cord-019043-cqmqwl3i 181 7 patients patient NNS cord-019043-cqmqwl3i 181 8 have have VBP cord-019043-cqmqwl3i 181 9 shown show VBN cord-019043-cqmqwl3i 181 10 no no DT cord-019043-cqmqwl3i 181 11 incremental incremental JJ cord-019043-cqmqwl3i 181 12 outcome outcome NN cord-019043-cqmqwl3i 181 13 benefit benefit NN cord-019043-cqmqwl3i 181 14 for for IN cord-019043-cqmqwl3i 181 15 a a DT cord-019043-cqmqwl3i 181 16 strategy strategy NN cord-019043-cqmqwl3i 181 17 of of IN cord-019043-cqmqwl3i 181 18 " " `` cord-019043-cqmqwl3i 181 19 trophic trophic NN cord-019043-cqmqwl3i 181 20 " " '' cord-019043-cqmqwl3i 181 21 feeds feed NNS cord-019043-cqmqwl3i 181 22 ( ( -LRB- cord-019043-cqmqwl3i 181 23 i.e. i.e. FW cord-019043-cqmqwl3i 181 24 , , , cord-019043-cqmqwl3i 181 25 10 10 CD cord-019043-cqmqwl3i 181 26 - - SYM cord-019043-cqmqwl3i 181 27 25 25 CD cord-019043-cqmqwl3i 181 28 mL ml NN cord-019043-cqmqwl3i 181 29 / / SYM cord-019043-cqmqwl3i 181 30 h h NN cord-019043-cqmqwl3i 181 31 ) ) -RRB- cord-019043-cqmqwl3i 181 32 during during IN cord-019043-cqmqwl3i 181 33 the the DT cord-019043-cqmqwl3i 181 34 first first JJ cord-019043-cqmqwl3i 181 35 few few JJ cord-019043-cqmqwl3i 181 36 days day NNS cord-019043-cqmqwl3i 181 37 of of IN cord-019043-cqmqwl3i 181 38 critical critical JJ cord-019043-cqmqwl3i 181 39 illness illness NN cord-019043-cqmqwl3i 181 40 . . . cord-019043-cqmqwl3i 182 1 Likewise likewise RB cord-019043-cqmqwl3i 182 2 , , , cord-019043-cqmqwl3i 182 3 high high JJ cord-019043-cqmqwl3i 182 4 - - HYPH cord-019043-cqmqwl3i 182 5 quality quality NN cord-019043-cqmqwl3i 182 6 evidence evidence NN cord-019043-cqmqwl3i 182 7 to to TO cord-019043-cqmqwl3i 182 8 support support VB cord-019043-cqmqwl3i 182 9 a a DT cord-019043-cqmqwl3i 182 10 strategy strategy NN cord-019043-cqmqwl3i 182 11 of of IN cord-019043-cqmqwl3i 182 12 intentional intentional JJ cord-019043-cqmqwl3i 182 13 " " `` cord-019043-cqmqwl3i 182 14 permissive permissive JJ cord-019043-cqmqwl3i 182 15 hypofeeding hypofeeding NN cord-019043-cqmqwl3i 182 16 " " '' cord-019043-cqmqwl3i 182 17 ( ( -LRB- cord-019043-cqmqwl3i 182 18 target target VB cord-019043-cqmqwl3i 182 19 60 60 CD cord-019043-cqmqwl3i 182 20 - - SYM cord-019043-cqmqwl3i 182 21 70 70 CD cord-019043-cqmqwl3i 182 22 % % NN cord-019043-cqmqwl3i 182 23 total total JJ cord-019043-cqmqwl3i 182 24 caloric caloric JJ cord-019043-cqmqwl3i 182 25 intake intake NN cord-019043-cqmqwl3i 182 26 ) ) -RRB- cord-019043-cqmqwl3i 182 27 is be VBZ cord-019043-cqmqwl3i 182 28 currently currently RB cord-019043-cqmqwl3i 182 29 lacking lack VBG cord-019043-cqmqwl3i 182 30 and and CC cord-019043-cqmqwl3i 182 31 can can MD cord-019043-cqmqwl3i 182 32 not not RB cord-019043-cqmqwl3i 182 33 be be VB cord-019043-cqmqwl3i 182 34 recommended recommend VBN cord-019043-cqmqwl3i 182 35 . . . cord-019043-cqmqwl3i 183 1 Measures measure NNS cord-019043-cqmqwl3i 183 2 to to TO cord-019043-cqmqwl3i 183 3 improve improve VB cord-019043-cqmqwl3i 183 4 the the DT cord-019043-cqmqwl3i 183 5 success success NN cord-019043-cqmqwl3i 183 6 of of IN cord-019043-cqmqwl3i 183 7 enteric enteric JJ cord-019043-cqmqwl3i 183 8 nutritional nutritional JJ cord-019043-cqmqwl3i 183 9 support support NN cord-019043-cqmqwl3i 183 10 include include VBP cord-019043-cqmqwl3i 183 11 use use NN cord-019043-cqmqwl3i 183 12 of of IN cord-019043-cqmqwl3i 183 13 prokinetic prokinetic JJ cord-019043-cqmqwl3i 183 14 agents agent NNS cord-019043-cqmqwl3i 183 15 ( ( -LRB- cord-019043-cqmqwl3i 183 16 i.e. i.e. FW cord-019043-cqmqwl3i 183 17 , , , cord-019043-cqmqwl3i 183 18 dose dose RB cord-019043-cqmqwl3i 183 19 - - HYPH cord-019043-cqmqwl3i 183 20 adjusted adjust VBN cord-019043-cqmqwl3i 183 21 metoclopramide metoclopramide NN cord-019043-cqmqwl3i 183 22 , , , cord-019043-cqmqwl3i 183 23 domperidone domperidone NNP cord-019043-cqmqwl3i 183 24 ) ) -RRB- cord-019043-cqmqwl3i 183 25 , , , cord-019043-cqmqwl3i 183 26 advancement advancement NN cord-019043-cqmqwl3i 183 27 of of IN cord-019043-cqmqwl3i 183 28 small small JJ cord-019043-cqmqwl3i 183 29 bowel bowel NN cord-019043-cqmqwl3i 183 30 feeding feeding NN cord-019043-cqmqwl3i 183 31 tubes tube NNS cord-019043-cqmqwl3i 183 32 , , , cord-019043-cqmqwl3i 183 33 elevation elevation NN cord-019043-cqmqwl3i 183 34 of of IN cord-019043-cqmqwl3i 183 35 the the DT cord-019043-cqmqwl3i 183 36 head head NN cord-019043-cqmqwl3i 183 37 of of IN cord-019043-cqmqwl3i 183 38 the the DT cord-019043-cqmqwl3i 183 39 bed bed NN cord-019043-cqmqwl3i 183 40 ( ( -LRB- cord-019043-cqmqwl3i 183 41 ~30 ~30 CD cord-019043-cqmqwl3i 183 42 - - SYM cord-019043-cqmqwl3i 183 43 45 45 CD cord-019043-cqmqwl3i 183 44 ° ° NN cord-019043-cqmqwl3i 183 45 ) ) -RRB- cord-019043-cqmqwl3i 183 46 , , , cord-019043-cqmqwl3i 183 47 and and CC cord-019043-cqmqwl3i 183 48 not not RB cord-019043-cqmqwl3i 183 49 using use VBG cord-019043-cqmqwl3i 183 50 specified specify VBN cord-019043-cqmqwl3i 183 51 gastric gastric JJ cord-019043-cqmqwl3i 183 52 residual residual JJ cord-019043-cqmqwl3i 183 53 thresholds threshold NNS cord-019043-cqmqwl3i 183 54 that that WDT cord-019043-cqmqwl3i 183 55 often often RB cord-019043-cqmqwl3i 183 56 result result VBP cord-019043-cqmqwl3i 183 57 in in IN cord-019043-cqmqwl3i 183 58 suboptimal suboptimal JJ cord-019043-cqmqwl3i 183 59 delivery delivery NN cord-019043-cqmqwl3i 183 60 of of IN cord-019043-cqmqwl3i 183 61 targeted target VBN cord-019043-cqmqwl3i 183 62 feeds feed NNS cord-019043-cqmqwl3i 183 63 . . . cord-019043-cqmqwl3i 184 1 If if IN cord-019043-cqmqwl3i 184 2 there there EX cord-019043-cqmqwl3i 184 3 remains remain VBZ cord-019043-cqmqwl3i 184 4 intolerance intolerance NN cord-019043-cqmqwl3i 184 5 to to IN cord-019043-cqmqwl3i 184 6 EN en NN cord-019043-cqmqwl3i 184 7 and and CC cord-019043-cqmqwl3i 184 8 failure failure NN cord-019043-cqmqwl3i 184 9 to to TO cord-019043-cqmqwl3i 184 10 meet meet VB cord-019043-cqmqwl3i 184 11 nutritional nutritional JJ cord-019043-cqmqwl3i 184 12 targets target NNS cord-019043-cqmqwl3i 184 13 with with IN cord-019043-cqmqwl3i 184 14 EN EN NNP cord-019043-cqmqwl3i 184 15 , , , cord-019043-cqmqwl3i 184 16 or or CC cord-019043-cqmqwl3i 184 17 there there EX cord-019043-cqmqwl3i 184 18 are be VBP cord-019043-cqmqwl3i 184 19 other other JJ cord-019043-cqmqwl3i 184 20 medical medical JJ cord-019043-cqmqwl3i 184 21 or or CC cord-019043-cqmqwl3i 184 22 surgical surgical JJ cord-019043-cqmqwl3i 184 23 reasons reason NNS cord-019043-cqmqwl3i 184 24 to to TO cord-019043-cqmqwl3i 184 25 avoid avoid VB cord-019043-cqmqwl3i 184 26 EN EN NNP cord-019043-cqmqwl3i 184 27 , , , cord-019043-cqmqwl3i 184 28 current current JJ cord-019043-cqmqwl3i 184 29 evidence evidence NN cord-019043-cqmqwl3i 184 30 would would MD cord-019043-cqmqwl3i 184 31 suggest suggest VB cord-019043-cqmqwl3i 184 32 starting start VBG cord-019043-cqmqwl3i 184 33 total total JJ cord-019043-cqmqwl3i 184 34 parenteral parenteral JJ cord-019043-cqmqwl3i 184 35 nutrition nutrition NN cord-019043-cqmqwl3i 184 36 ( ( -LRB- cord-019043-cqmqwl3i 184 37 TPN TPN NNP cord-019043-cqmqwl3i 184 38 ) ) -RRB- cord-019043-cqmqwl3i 184 39 after after IN cord-019043-cqmqwl3i 184 40 a a DT cord-019043-cqmqwl3i 184 41 period period NN cord-019043-cqmqwl3i 184 42 of of IN cord-019043-cqmqwl3i 184 43 several several JJ cord-019043-cqmqwl3i 184 44 days day NNS cord-019043-cqmqwl3i 184 45 . . . cord-019043-cqmqwl3i 185 1 The the DT cord-019043-cqmqwl3i 185 2 optimal optimal JJ cord-019043-cqmqwl3i 185 3 amount amount NN cord-019043-cqmqwl3i 185 4 of of IN cord-019043-cqmqwl3i 185 5 protein protein NN cord-019043-cqmqwl3i 185 6 supplementation supplementation NN cord-019043-cqmqwl3i 185 7 in in IN cord-019043-cqmqwl3i 185 8 AKI AKI NNP cord-019043-cqmqwl3i 185 9 is be VBZ cord-019043-cqmqwl3i 185 10 unknown unknown JJ cord-019043-cqmqwl3i 185 11 . . . cord-019043-cqmqwl3i 186 1 Current current JJ cord-019043-cqmqwl3i 186 2 practice practice NN cord-019043-cqmqwl3i 186 3 guideline guideline NN cord-019043-cqmqwl3i 186 4 recommendations recommendation NNS cord-019043-cqmqwl3i 186 5 are be VBP cord-019043-cqmqwl3i 186 6 to to TO cord-019043-cqmqwl3i 186 7 avoid avoid VB cord-019043-cqmqwl3i 186 8 protein protein NN cord-019043-cqmqwl3i 186 9 restriction restriction NN cord-019043-cqmqwl3i 186 10 in in IN cord-019043-cqmqwl3i 186 11 critically critically RB cord-019043-cqmqwl3i 186 12 ill ill JJ cord-019043-cqmqwl3i 186 13 patients patient NNS cord-019043-cqmqwl3i 186 14 if if IN cord-019043-cqmqwl3i 186 15 the the DT cord-019043-cqmqwl3i 186 16 intent intent NN cord-019043-cqmqwl3i 186 17 is be VBZ cord-019043-cqmqwl3i 186 18 to to TO cord-019043-cqmqwl3i 186 19 prevent prevent VB cord-019043-cqmqwl3i 186 20 worsening worsen VBG cord-019043-cqmqwl3i 186 21 azotemia azotemia NN cord-019043-cqmqwl3i 186 22 with with IN cord-019043-cqmqwl3i 186 23 the the DT cord-019043-cqmqwl3i 186 24 goal goal NN cord-019043-cqmqwl3i 186 25 of of IN cord-019043-cqmqwl3i 186 26 preventing prevent VBG cord-019043-cqmqwl3i 186 27 or or CC cord-019043-cqmqwl3i 186 28 delaying delay VBG cord-019043-cqmqwl3i 186 29 the the DT cord-019043-cqmqwl3i 186 30 initiation initiation NN cord-019043-cqmqwl3i 186 31 of of IN cord-019043-cqmqwl3i 186 32 RRT RRT NNP cord-019043-cqmqwl3i 186 33 . . . cord-019043-cqmqwl3i 187 1 Indeed indeed RB cord-019043-cqmqwl3i 187 2 , , , cord-019043-cqmqwl3i 187 3 patients patient NNS cord-019043-cqmqwl3i 187 4 with with IN cord-019043-cqmqwl3i 187 5 AKI AKI NNP cord-019043-cqmqwl3i 187 6 are be VBP cord-019043-cqmqwl3i 187 7 often often RB cord-019043-cqmqwl3i 187 8 catabolic catabolic JJ cord-019043-cqmqwl3i 187 9 and and CC cord-019043-cqmqwl3i 187 10 require require VBP cord-019043-cqmqwl3i 187 11 protein protein NN cord-019043-cqmqwl3i 187 12 supplementation supplementation NN cord-019043-cqmqwl3i 187 13 , , , cord-019043-cqmqwl3i 187 14 in in IN cord-019043-cqmqwl3i 187 15 particular particular JJ cord-019043-cqmqwl3i 187 16 to to TO cord-019043-cqmqwl3i 187 17 account account VB cord-019043-cqmqwl3i 187 18 for for IN cord-019043-cqmqwl3i 187 19 the the DT cord-019043-cqmqwl3i 187 20 added add VBN cord-019043-cqmqwl3i 187 21 clearance clearance NN cord-019043-cqmqwl3i 187 22 of of IN cord-019043-cqmqwl3i 187 23 amino amino JJ cord-019043-cqmqwl3i 187 24 acids acid NNS cord-019043-cqmqwl3i 187 25 while while IN cord-019043-cqmqwl3i 187 26 receiving receive VBG cord-019043-cqmqwl3i 187 27 RRT RRT NNP cord-019043-cqmqwl3i 187 28 . . . cord-019043-cqmqwl3i 188 1 There there EX cord-019043-cqmqwl3i 188 2 is be VBZ cord-019043-cqmqwl3i 188 3 insufficient insufficient JJ cord-019043-cqmqwl3i 188 4 data datum NNS cord-019043-cqmqwl3i 188 5 to to TO cord-019043-cqmqwl3i 188 6 suggest suggest VB cord-019043-cqmqwl3i 188 7 the the DT cord-019043-cqmqwl3i 188 8 use use NN cord-019043-cqmqwl3i 188 9 of of IN cord-019043-cqmqwl3i 188 10 routine routine JJ cord-019043-cqmqwl3i 188 11 micronutrient micronutrient NN cord-019043-cqmqwl3i 188 12 supplementation supplementation NN cord-019043-cqmqwl3i 188 13 [ [ -LRB- cord-019043-cqmqwl3i 188 14 6 6 CD cord-019043-cqmqwl3i 188 15 ] ] -RRB- cord-019043-cqmqwl3i 188 16 . . . cord-019043-cqmqwl3i 189 1 In in IN cord-019043-cqmqwl3i 189 2 fact fact NN cord-019043-cqmqwl3i 189 3 , , , cord-019043-cqmqwl3i 189 4 there there EX cord-019043-cqmqwl3i 189 5 is be VBZ cord-019043-cqmqwl3i 189 6 an an DT cord-019043-cqmqwl3i 189 7 increased increased JJ cord-019043-cqmqwl3i 189 8 risk risk NN cord-019043-cqmqwl3i 189 9 of of IN cord-019043-cqmqwl3i 189 10 mortality mortality NN cord-019043-cqmqwl3i 189 11 associated associate VBN cord-019043-cqmqwl3i 189 12 with with IN cord-019043-cqmqwl3i 189 13 the the DT cord-019043-cqmqwl3i 189 14 use use NN cord-019043-cqmqwl3i 189 15 of of IN cord-019043-cqmqwl3i 189 16 glutamine glutamine NN cord-019043-cqmqwl3i 189 17 in in IN cord-019043-cqmqwl3i 189 18 patients patient NNS cord-019043-cqmqwl3i 189 19 with with IN cord-019043-cqmqwl3i 189 20 multiorgan multiorgan NNP cord-019043-cqmqwl3i 189 21 failure failure NN cord-019043-cqmqwl3i 189 22 . . . cord-019043-cqmqwl3i 190 1 The the DT cord-019043-cqmqwl3i 190 2 acute acute JJ cord-019043-cqmqwl3i 190 3 stress stress NN cord-019043-cqmqwl3i 190 4 of of IN cord-019043-cqmqwl3i 190 5 critical critical JJ cord-019043-cqmqwl3i 190 6 illness illness NN cord-019043-cqmqwl3i 190 7 coupled couple VBN cord-019043-cqmqwl3i 190 8 with with IN cord-019043-cqmqwl3i 190 9 nutritional nutritional JJ cord-019043-cqmqwl3i 190 10 support support NN cord-019043-cqmqwl3i 190 11 can can MD cord-019043-cqmqwl3i 190 12 often often RB cord-019043-cqmqwl3i 190 13 precipitate precipitate VB cord-019043-cqmqwl3i 190 14 stress stress NN cord-019043-cqmqwl3i 190 15 - - HYPH cord-019043-cqmqwl3i 190 16 induced induce VBN cord-019043-cqmqwl3i 190 17 hyperglycemia hyperglycemia NN cord-019043-cqmqwl3i 190 18 . . . cord-019043-cqmqwl3i 191 1 The the DT cord-019043-cqmqwl3i 191 2 avoidance avoidance NN cord-019043-cqmqwl3i 191 3 of of IN cord-019043-cqmqwl3i 191 4 significant significant JJ cord-019043-cqmqwl3i 191 5 hyperglycemia hyperglycemia NN cord-019043-cqmqwl3i 191 6 , , , cord-019043-cqmqwl3i 191 7 hypoglycemia hypoglycemia NN cord-019043-cqmqwl3i 191 8 , , , cord-019043-cqmqwl3i 191 9 and and CC cord-019043-cqmqwl3i 191 10 variation variation NN cord-019043-cqmqwl3i 191 11 in in IN cord-019043-cqmqwl3i 191 12 glycemic glycemic JJ cord-019043-cqmqwl3i 191 13 control control NN cord-019043-cqmqwl3i 191 14 is be VBZ cord-019043-cqmqwl3i 191 15 associated associate VBN cord-019043-cqmqwl3i 191 16 with with IN cord-019043-cqmqwl3i 191 17 improved improved JJ cord-019043-cqmqwl3i 191 18 outcomes outcome NNS cord-019043-cqmqwl3i 191 19 . . . cord-019043-cqmqwl3i 192 1 However however RB cord-019043-cqmqwl3i 192 2 , , , cord-019043-cqmqwl3i 192 3 recent recent JJ cord-019043-cqmqwl3i 192 4 trials trial NNS cord-019043-cqmqwl3i 192 5 have have VBP cord-019043-cqmqwl3i 192 6 suggested suggest VBN cord-019043-cqmqwl3i 192 7 that that IN cord-019043-cqmqwl3i 192 8 tight tight JJ cord-019043-cqmqwl3i 192 9 glycemic glycemic JJ cord-019043-cqmqwl3i 192 10 control control NN cord-019043-cqmqwl3i 192 11 ( ( -LRB- cord-019043-cqmqwl3i 192 12 TGC TGC NNP cord-019043-cqmqwl3i 192 13 ) ) -RRB- cord-019043-cqmqwl3i 192 14 with with IN cord-019043-cqmqwl3i 192 15 intensive intensive JJ cord-019043-cqmqwl3i 192 16 insulin insulin NN cord-019043-cqmqwl3i 192 17 therapy therapy NN cord-019043-cqmqwl3i 192 18 ( ( -LRB- cord-019043-cqmqwl3i 192 19 IIT IIT NNP cord-019043-cqmqwl3i 192 20 ) ) -RRB- cord-019043-cqmqwl3i 192 21 ( ( -LRB- cord-019043-cqmqwl3i 192 22 BG BG NNP cord-019043-cqmqwl3i 192 23 4.4 4.4 CD cord-019043-cqmqwl3i 192 24 - - HYPH cord-019043-cqmqwl3i 192 25 6.0 6.0 CD cord-019043-cqmqwl3i 192 26 mmol mmol NN cord-019043-cqmqwl3i 192 27 / / SYM cord-019043-cqmqwl3i 192 28 L L NNP cord-019043-cqmqwl3i 192 29 ) ) -RRB- cord-019043-cqmqwl3i 192 30 may may MD cord-019043-cqmqwl3i 192 31 be be VB cord-019043-cqmqwl3i 192 32 associated associate VBN cord-019043-cqmqwl3i 192 33 with with IN cord-019043-cqmqwl3i 192 34 increased increase VBN cord-019043-cqmqwl3i 192 35 risk risk NN cord-019043-cqmqwl3i 192 36 for for IN cord-019043-cqmqwl3i 192 37 hypoglycemia hypoglycemia NN cord-019043-cqmqwl3i 192 38 and and CC cord-019043-cqmqwl3i 192 39 worse bad JJR cord-019043-cqmqwl3i 192 40 outcome outcome NN cord-019043-cqmqwl3i 192 41 . . . cord-019043-cqmqwl3i 193 1 Accordingly accordingly RB cord-019043-cqmqwl3i 193 2 , , , cord-019043-cqmqwl3i 193 3 current current JJ cord-019043-cqmqwl3i 193 4 practice practice NN cord-019043-cqmqwl3i 193 5 guidelines guideline NNS cord-019043-cqmqwl3i 193 6 recommend recommend VBP cord-019043-cqmqwl3i 193 7 a a DT cord-019043-cqmqwl3i 193 8 more more RBR cord-019043-cqmqwl3i 193 9 pragmatic pragmatic JJ cord-019043-cqmqwl3i 193 10 and and CC cord-019043-cqmqwl3i 193 11 less less RBR cord-019043-cqmqwl3i 193 12 intensive intensive JJ cord-019043-cqmqwl3i 193 13 strategy strategy NN cord-019043-cqmqwl3i 193 14 targeting target VBG cord-019043-cqmqwl3i 193 15 glycemic glycemic JJ cord-019043-cqmqwl3i 193 16 control control NN cord-019043-cqmqwl3i 193 17 between between IN cord-019043-cqmqwl3i 193 18 6.1 6.1 CD cord-019043-cqmqwl3i 193 19 and and CC cord-019043-cqmqwl3i 193 20 10.0 10.0 CD cord-019043-cqmqwl3i 193 21 mmol mmol JJ cord-019043-cqmqwl3i 193 22 / / SYM cord-019043-cqmqwl3i 193 23 L L NNP cord-019043-cqmqwl3i 193 24 ( ( -LRB- cord-019043-cqmqwl3i 193 25 110 110 CD cord-019043-cqmqwl3i 193 26 - - SYM cord-019043-cqmqwl3i 193 27 180 180 CD cord-019043-cqmqwl3i 193 28 mg mg NNP cord-019043-cqmqwl3i 193 29 / / SYM cord-019043-cqmqwl3i 193 30 dL dl NN cord-019043-cqmqwl3i 193 31 ) ) -RRB- cord-019043-cqmqwl3i 193 32 ( ( -LRB- cord-019043-cqmqwl3i 193 33 Box Box NNP cord-019043-cqmqwl3i 193 34 32.4 32.4 CD cord-019043-cqmqwl3i 193 35 ) ) -RRB- cord-019043-cqmqwl3i 193 36 . . . cord-019043-cqmqwl3i 194 1 Sepsis sepsis NN cord-019043-cqmqwl3i 194 2 is be VBZ cord-019043-cqmqwl3i 194 3 an an DT cord-019043-cqmqwl3i 194 4 important important JJ cord-019043-cqmqwl3i 194 5 precipitant precipitant NN cord-019043-cqmqwl3i 194 6 of of IN cord-019043-cqmqwl3i 194 7 critical critical JJ cord-019043-cqmqwl3i 194 8 illness illness NN cord-019043-cqmqwl3i 194 9 and and CC cord-019043-cqmqwl3i 194 10 commonly commonly RB cord-019043-cqmqwl3i 194 11 prompts prompt VBZ cord-019043-cqmqwl3i 194 12 acute acute JJ cord-019043-cqmqwl3i 194 13 hospitalization hospitalization NN cord-019043-cqmqwl3i 194 14 and and CC cord-019043-cqmqwl3i 194 15 admission admission NN cord-019043-cqmqwl3i 194 16 to to IN cord-019043-cqmqwl3i 194 17 ICU ICU NNP cord-019043-cqmqwl3i 194 18 . . . cord-019043-cqmqwl3i 195 1 Data datum NNS cord-019043-cqmqwl3i 195 2 from from IN cord-019043-cqmqwl3i 195 3 the the DT cord-019043-cqmqwl3i 195 4 USRDS USRDS NNP cord-019043-cqmqwl3i 195 5 suggest suggest VBP cord-019043-cqmqwl3i 195 6 infection infection NN cord-019043-cqmqwl3i 195 7 is be VBZ cord-019043-cqmqwl3i 195 8 the the DT cord-019043-cqmqwl3i 195 9 leading leading JJ cord-019043-cqmqwl3i 195 10 cause cause NN cord-019043-cqmqwl3i 195 11 of of IN cord-019043-cqmqwl3i 195 12 death death NN cord-019043-cqmqwl3i 195 13 among among IN cord-019043-cqmqwl3i 195 14 patients patient NNS cord-019043-cqmqwl3i 195 15 with with IN cord-019043-cqmqwl3i 195 16 ESRD ESRD NNP cord-019043-cqmqwl3i 195 17 . . . cord-019043-cqmqwl3i 196 1 CKD CKD NNP cord-019043-cqmqwl3i 196 2 patients patient NNS cord-019043-cqmqwl3i 196 3 may may MD cord-019043-cqmqwl3i 196 4 be be VB cord-019043-cqmqwl3i 196 5 more more RBR cord-019043-cqmqwl3i 196 6 susceptible susceptible JJ cord-019043-cqmqwl3i 196 7 to to IN cord-019043-cqmqwl3i 196 8 development development NN cord-019043-cqmqwl3i 196 9 of of IN cord-019043-cqmqwl3i 196 10 infectious infectious JJ cord-019043-cqmqwl3i 196 11 complications complication NNS cord-019043-cqmqwl3i 196 12 and and CC cord-019043-cqmqwl3i 196 13 sepsis sepsis NN cord-019043-cqmqwl3i 196 14 for for IN cord-019043-cqmqwl3i 196 15 a a DT cord-019043-cqmqwl3i 196 16 number number NN cord-019043-cqmqwl3i 196 17 of of IN cord-019043-cqmqwl3i 196 18 reasons reason NNS cord-019043-cqmqwl3i 196 19 including include VBG cord-019043-cqmqwl3i 196 20 : : : cord-019043-cqmqwl3i 196 21 • • XX cord-019043-cqmqwl3i 197 1 Presence presence NN cord-019043-cqmqwl3i 197 2 and and CC cord-019043-cqmqwl3i 197 3 repeated repeat VBD cord-019043-cqmqwl3i 197 4 access access NN cord-019043-cqmqwl3i 197 5 to to IN cord-019043-cqmqwl3i 197 6 indwelling indwell VBG cord-019043-cqmqwl3i 197 7 central central JJ cord-019043-cqmqwl3i 197 8 venous venous JJ cord-019043-cqmqwl3i 197 9 catheters catheter NNS cord-019043-cqmqwl3i 197 10 ( ( -LRB- cord-019043-cqmqwl3i 197 11 CVC CVC NNP cord-019043-cqmqwl3i 197 12 ) ) -RRB- cord-019043-cqmqwl3i 197 13 and and CC cord-019043-cqmqwl3i 197 14 arteriovenous arteriovenous JJ cord-019043-cqmqwl3i 197 15 fistulas fistula NNS cord-019043-cqmqwl3i 197 16 ( ( -LRB- cord-019043-cqmqwl3i 197 17 AVP AVP NNP cord-019043-cqmqwl3i 197 18 ) ) -RRB- cord-019043-cqmqwl3i 197 19 for for IN cord-019043-cqmqwl3i 197 20 dialysis dialysis NN cord-019043-cqmqwl3i 197 21 access access NN cord-019043-cqmqwl3i 198 1 • • NNP cord-019043-cqmqwl3i 198 2 Acquired acquire VBD cord-019043-cqmqwl3i 198 3 immunodeficiency immunodeficiency NN cord-019043-cqmqwl3i 198 4 related relate VBN cord-019043-cqmqwl3i 198 5 to to IN cord-019043-cqmqwl3i 198 6 primary primary JJ cord-019043-cqmqwl3i 198 7 etiology etiology NN cord-019043-cqmqwl3i 198 8 of of IN cord-019043-cqmqwl3i 198 9 kidney kidney NN cord-019043-cqmqwl3i 198 10 disease disease NN cord-019043-cqmqwl3i 199 1 • • NNP cord-019043-cqmqwl3i 200 1 Immune immune JJ cord-019043-cqmqwl3i 200 2 dysregulation dysregulation NN cord-019043-cqmqwl3i 200 3 related relate VBN cord-019043-cqmqwl3i 200 4 to to IN cord-019043-cqmqwl3i 200 5 retention retention NN cord-019043-cqmqwl3i 200 6 of of IN cord-019043-cqmqwl3i 200 7 uremic uremic JJ cord-019043-cqmqwl3i 200 8 toxins toxin NNS cord-019043-cqmqwl3i 200 9 ( ( -LRB- cord-019043-cqmqwl3i 200 10 i.e. i.e. FW cord-019043-cqmqwl3i 200 11 , , , cord-019043-cqmqwl3i 200 12 defective defective JJ cord-019043-cqmqwl3i 200 13 host host NN cord-019043-cqmqwl3i 200 14 responses response NNS cord-019043-cqmqwl3i 200 15 in in IN cord-019043-cqmqwl3i 200 16 phagocytic phagocytic JJ cord-019043-cqmqwl3i 200 17 cells cell NNS cord-019043-cqmqwl3i 200 18 , , , cord-019043-cqmqwl3i 200 19 lymphocytes lymphocyte NNS cord-019043-cqmqwl3i 200 20 , , , cord-019043-cqmqwl3i 200 21 and and CC cord-019043-cqmqwl3i 200 22 antigen antigen NN cord-019043-cqmqwl3i 200 23 processing processing NN cord-019043-cqmqwl3i 200 24 , , , cord-019043-cqmqwl3i 200 25 dysbiosis dysbiosis NN cord-019043-cqmqwl3i 200 26 of of IN cord-019043-cqmqwl3i 200 27 gut gut NN cord-019043-cqmqwl3i 200 28 microflora microflora NN cord-019043-cqmqwl3i 200 29 ) ) -RRB- cord-019043-cqmqwl3i 201 1 • • NNP cord-019043-cqmqwl3i 202 1 Repeated repeat VBN cord-019043-cqmqwl3i 202 2 episodes episode NNS cord-019043-cqmqwl3i 202 3 of of IN cord-019043-cqmqwl3i 202 4 systemic systemic JJ cord-019043-cqmqwl3i 202 5 inflammation inflammation NN cord-019043-cqmqwl3i 202 6 related relate VBN cord-019043-cqmqwl3i 202 7 to to IN cord-019043-cqmqwl3i 202 8 altered alter VBN cord-019043-cqmqwl3i 202 9 gut gut NN cord-019043-cqmqwl3i 202 10 permeability permeability NN cord-019043-cqmqwl3i 202 11 and and CC cord-019043-cqmqwl3i 202 12 bacterial bacterial JJ cord-019043-cqmqwl3i 202 13 / / SYM cord-019043-cqmqwl3i 202 14 endotoxin endotoxin NN cord-019043-cqmqwl3i 202 15 translocation translocation NN cord-019043-cqmqwl3i 202 16 during during IN cord-019043-cqmqwl3i 202 17 dialysis dialysis NN cord-019043-cqmqwl3i 203 1 This this DT cord-019043-cqmqwl3i 203 2 risk risk NN cord-019043-cqmqwl3i 203 3 is be VBZ cord-019043-cqmqwl3i 203 4 further further RB cord-019043-cqmqwl3i 203 5 modified modify VBN cord-019043-cqmqwl3i 203 6 by by IN cord-019043-cqmqwl3i 203 7 additional additional JJ cord-019043-cqmqwl3i 203 8 factors factor NNS cord-019043-cqmqwl3i 203 9 such such JJ cord-019043-cqmqwl3i 203 10 as as IN cord-019043-cqmqwl3i 203 11 comorbid comorbid NN cord-019043-cqmqwl3i 203 12 disease disease NN cord-019043-cqmqwl3i 203 13 ( ( -LRB- cord-019043-cqmqwl3i 203 14 i.e. i.e. FW cord-019043-cqmqwl3i 203 15 , , , cord-019043-cqmqwl3i 203 16 peripheral peripheral JJ cord-019043-cqmqwl3i 203 17 vascular vascular JJ cord-019043-cqmqwl3i 203 18 disease disease NN cord-019043-cqmqwl3i 203 19 and and CC cord-019043-cqmqwl3i 203 20 diabetes diabetes NN cord-019043-cqmqwl3i 203 21 mellitus mellitus NN cord-019043-cqmqwl3i 203 22 , , , cord-019043-cqmqwl3i 203 23 smoking smoking NN cord-019043-cqmqwl3i 203 24 ) ) -RRB- cord-019043-cqmqwl3i 203 25 and and CC cord-019043-cqmqwl3i 203 26 frequent frequent JJ cord-019043-cqmqwl3i 203 27 interaction interaction NN cord-019043-cqmqwl3i 203 28 with with IN cord-019043-cqmqwl3i 203 29 health health NN cord-019043-cqmqwl3i 203 30 - - HYPH cord-019043-cqmqwl3i 203 31 care care NN cord-019043-cqmqwl3i 203 32 services service NNS cord-019043-cqmqwl3i 203 33 ( ( -LRB- cord-019043-cqmqwl3i 203 34 i.e. i.e. FW cord-019043-cqmqwl3i 203 35 , , , cord-019043-cqmqwl3i 203 36 colonization colonization NN cord-019043-cqmqwl3i 203 37 with with IN cord-019043-cqmqwl3i 203 38 antimicrobial antimicrobial JJ cord-019043-cqmqwl3i 203 39 - - HYPH cord-019043-cqmqwl3i 203 40 resistant resistant JJ cord-019043-cqmqwl3i 203 41 The the DT cord-019043-cqmqwl3i 203 42 utilization utilization NN cord-019043-cqmqwl3i 203 43 of of IN cord-019043-cqmqwl3i 203 44 indwelling indwell VBG cord-019043-cqmqwl3i 203 45 access access NN cord-019043-cqmqwl3i 203 46 catheters catheter NNS cord-019043-cqmqwl3i 203 47 is be VBZ cord-019043-cqmqwl3i 203 48 a a DT cord-019043-cqmqwl3i 203 49 significant significant JJ cord-019043-cqmqwl3i 203 50 source source NN cord-019043-cqmqwl3i 203 51 of of IN cord-019043-cqmqwl3i 203 52 bloodstream bloodstream NN cord-019043-cqmqwl3i 203 53 infection infection NN cord-019043-cqmqwl3i 203 54 and and CC cord-019043-cqmqwl3i 203 55 sepsis sepsis NN cord-019043-cqmqwl3i 203 56 in in IN cord-019043-cqmqwl3i 203 57 CKD CKD NNP cord-019043-cqmqwl3i 203 58 / / SYM cord-019043-cqmqwl3i 203 59 ESRD ESRD NNP cord-019043-cqmqwl3i 203 60 patients patient NNS cord-019043-cqmqwl3i 203 61 , , , cord-019043-cqmqwl3i 203 62 is be VBZ cord-019043-cqmqwl3i 203 63 directly directly RB cord-019043-cqmqwl3i 203 64 related relate VBN cord-019043-cqmqwl3i 203 65 to to IN cord-019043-cqmqwl3i 203 66 the the DT cord-019043-cqmqwl3i 203 67 duration duration NN cord-019043-cqmqwl3i 203 68 of of IN cord-019043-cqmqwl3i 203 69 usage usage NN cord-019043-cqmqwl3i 204 1 , , , cord-019043-cqmqwl3i 204 2 is be VBZ cord-019043-cqmqwl3i 204 3 most most RBS cord-019043-cqmqwl3i 204 4 commonly commonly RB cord-019043-cqmqwl3i 204 5 caused cause VBN cord-019043-cqmqwl3i 204 6 by by IN cord-019043-cqmqwl3i 204 7 gram gram NN cord-019043-cqmqwl3i 204 8 - - HYPH cord-019043-cqmqwl3i 204 9 positive positive JJ cord-019043-cqmqwl3i 204 10 organism organism NN cord-019043-cqmqwl3i 204 11 ( ( -LRB- cord-019043-cqmqwl3i 204 12 coagulase coagulase NN cord-019043-cqmqwl3i 204 13 - - HYPH cord-019043-cqmqwl3i 204 14 negative negative JJ cord-019043-cqmqwl3i 204 15 staphylococcus staphylococcus NN cord-019043-cqmqwl3i 204 16 , , , cord-019043-cqmqwl3i 204 17 Staphylococcus Staphylococcus NNP cord-019043-cqmqwl3i 204 18 aureus aureus NN cord-019043-cqmqwl3i 204 19 ) ) -RRB- cord-019043-cqmqwl3i 204 20 , , , cord-019043-cqmqwl3i 204 21 and and CC cord-019043-cqmqwl3i 204 22 is be VBZ cord-019043-cqmqwl3i 204 23 associated associate VBN cord-019043-cqmqwl3i 204 24 with with IN cord-019043-cqmqwl3i 204 25 considerably considerably RB cord-019043-cqmqwl3i 204 26 higher high JJR cord-019043-cqmqwl3i 204 27 risk risk NN cord-019043-cqmqwl3i 204 28 of of IN cord-019043-cqmqwl3i 204 29 morbidity morbidity NN cord-019043-cqmqwl3i 204 30 and and CC cord-019043-cqmqwl3i 204 31 mortality mortality NN cord-019043-cqmqwl3i 204 32 . . . cord-019043-cqmqwl3i 205 1 The the DT cord-019043-cqmqwl3i 205 2 risk risk NN cord-019043-cqmqwl3i 205 3 is be VBZ cord-019043-cqmqwl3i 205 4 two two CD cord-019043-cqmqwl3i 205 5 - - : cord-019043-cqmqwl3i 205 6 to to TO cord-019043-cqmqwl3i 205 7 threefold threefold VB cord-019043-cqmqwl3i 205 8 higher higher RBR cord-019043-cqmqwl3i 205 9 for for IN cord-019043-cqmqwl3i 205 10 nontunneled nontunneled JJ cord-019043-cqmqwl3i 205 11 ( ( -LRB- cord-019043-cqmqwl3i 205 12 most most RBS cord-019043-cqmqwl3i 205 13 commonly commonly RB cord-019043-cqmqwl3i 205 14 inserted insert VBN cord-019043-cqmqwl3i 205 15 in in IN cord-019043-cqmqwl3i 205 16 the the DT cord-019043-cqmqwl3i 205 17 ICU ICU NNP cord-019043-cqmqwl3i 205 18 ) ) -RRB- cord-019043-cqmqwl3i 205 19 compared compare VBN cord-019043-cqmqwl3i 205 20 with with IN cord-019043-cqmqwl3i 205 21 tunneled tunnel VBN cord-019043-cqmqwl3i 205 22 catheters catheter NNS cord-019043-cqmqwl3i 205 23 . . . cord-019043-cqmqwl3i 206 1 For for IN cord-019043-cqmqwl3i 206 2 ESRD ESRD NNP cord-019043-cqmqwl3i 206 3 patients patient NNS cord-019043-cqmqwl3i 206 4 receiving receive VBG cord-019043-cqmqwl3i 206 5 dialysis dialysis NN cord-019043-cqmqwl3i 206 6 via via IN cord-019043-cqmqwl3i 206 7 tunneled tunnel VBN cord-019043-cqmqwl3i 206 8 catheters catheter NNS cord-019043-cqmqwl3i 206 9 , , , cord-019043-cqmqwl3i 206 10 the the DT cord-019043-cqmqwl3i 206 11 risk risk NN cord-019043-cqmqwl3i 206 12 of of IN cord-019043-cqmqwl3i 206 13 bloodstream bloodstream NN cord-019043-cqmqwl3i 206 14 infection infection NN cord-019043-cqmqwl3i 206 15 , , , cord-019043-cqmqwl3i 206 16 infectionrelated infectionrelate VBN cord-019043-cqmqwl3i 206 17 hospitalization hospitalization NN cord-019043-cqmqwl3i 206 18 , , , cord-019043-cqmqwl3i 206 19 and and CC cord-019043-cqmqwl3i 206 20 infection infection NN cord-019043-cqmqwl3i 206 21 - - HYPH cord-019043-cqmqwl3i 206 22 related relate VBN cord-019043-cqmqwl3i 206 23 death death NN cord-019043-cqmqwl3i 206 24 is be VBZ cord-019043-cqmqwl3i 206 25 further further RB cord-019043-cqmqwl3i 206 26 two two CD cord-019043-cqmqwl3i 206 27 - - HYPH cord-019043-cqmqwl3i 206 28 to to TO cord-019043-cqmqwl3i 206 29 threefold threefold VB cord-019043-cqmqwl3i 206 30 higher higher RBR cord-019043-cqmqwl3i 206 31 than than IN cord-019043-cqmqwl3i 206 32 for for IN cord-019043-cqmqwl3i 206 33 those those DT cord-019043-cqmqwl3i 206 34 receiving receive VBG cord-019043-cqmqwl3i 206 35 hemodialysis hemodialysis NN cord-019043-cqmqwl3i 206 36 via via IN cord-019043-cqmqwl3i 206 37 arteriovenous arteriovenous JJ cord-019043-cqmqwl3i 206 38 fistulas fistula NNS cord-019043-cqmqwl3i 206 39 or or CC cord-019043-cqmqwl3i 206 40 grafts graft NNS cord-019043-cqmqwl3i 206 41 . . . cord-019043-cqmqwl3i 207 1 Important important JJ cord-019043-cqmqwl3i 207 2 morbidity morbidity NN cord-019043-cqmqwl3i 207 3 from from IN cord-019043-cqmqwl3i 207 4 temporary temporary JJ cord-019043-cqmqwl3i 207 5 catheters catheter NNS cord-019043-cqmqwl3i 207 6 arises arise VBZ cord-019043-cqmqwl3i 207 7 from from IN cord-019043-cqmqwl3i 207 8 the the DT cord-019043-cqmqwl3i 207 9 risk risk NN cord-019043-cqmqwl3i 207 10 of of IN cord-019043-cqmqwl3i 207 11 development development NN cord-019043-cqmqwl3i 207 12 of of IN cord-019043-cqmqwl3i 207 13 metastatic metastatic JJ cord-019043-cqmqwl3i 207 14 foci foci NN cord-019043-cqmqwl3i 207 15 of of IN cord-019043-cqmqwl3i 207 16 infection infection NN cord-019043-cqmqwl3i 207 17 from from IN cord-019043-cqmqwl3i 207 18 highly highly RB cord-019043-cqmqwl3i 207 19 virulent virulent JJ cord-019043-cqmqwl3i 207 20 bacteria bacteria NNS cord-019043-cqmqwl3i 207 21 , , , cord-019043-cqmqwl3i 207 22 such such JJ cord-019043-cqmqwl3i 207 23 as as IN cord-019043-cqmqwl3i 207 24 Staphylococcus Staphylococcus NNP cord-019043-cqmqwl3i 207 25 aureus aureus NN cord-019043-cqmqwl3i 207 26 , , , cord-019043-cqmqwl3i 207 27 and and CC cord-019043-cqmqwl3i 207 28 includes include VBZ cord-019043-cqmqwl3i 207 29 endocarditis endocarditis NN cord-019043-cqmqwl3i 207 30 , , , cord-019043-cqmqwl3i 207 31 septic septic JJ cord-019043-cqmqwl3i 207 32 arthritis arthritis NN cord-019043-cqmqwl3i 207 33 , , , cord-019043-cqmqwl3i 207 34 osteoarthritis osteoarthritis NN cord-019043-cqmqwl3i 207 35 , , , cord-019043-cqmqwl3i 207 36 and and CC cord-019043-cqmqwl3i 207 37 epidural epidural NN cord-019043-cqmqwl3i 207 38 abscess abscess NN cord-019043-cqmqwl3i 207 39 . . . cord-019043-cqmqwl3i 208 1 The the DT cord-019043-cqmqwl3i 208 2 most most RBS cord-019043-cqmqwl3i 208 3 common common JJ cord-019043-cqmqwl3i 208 4 sources source NNS cord-019043-cqmqwl3i 208 5 of of IN cord-019043-cqmqwl3i 208 6 non non JJ cord-019043-cqmqwl3i 208 7 - - JJ cord-019043-cqmqwl3i 208 8 dialysisrelated dialysisrelated JJ cord-019043-cqmqwl3i 208 9 infections infection NNS cord-019043-cqmqwl3i 208 10 among among IN cord-019043-cqmqwl3i 208 11 CKD CKD NNP cord-019043-cqmqwl3i 208 12 / / SYM cord-019043-cqmqwl3i 208 13 ESRD ESRD NNP cord-019043-cqmqwl3i 208 14 patients patient NNS cord-019043-cqmqwl3i 208 15 are be VBP cord-019043-cqmqwl3i 208 16 : : : cord-019043-cqmqwl3i 209 1 • • NNP cord-019043-cqmqwl3i 209 2 Upper Upper NNP cord-019043-cqmqwl3i 209 3 and and CC cord-019043-cqmqwl3i 209 4 lower low JJR cord-019043-cqmqwl3i 210 1 respiratory respiratory JJ cord-019043-cqmqwl3i 210 2 tract tract NN cord-019043-cqmqwl3i 210 3 infections infection NNS cord-019043-cqmqwl3i 210 4 ( ( -LRB- cord-019043-cqmqwl3i 210 5 i.e. i.e. FW cord-019043-cqmqwl3i 210 6 , , , cord-019043-cqmqwl3i 210 7 community community NN cord-019043-cqmqwl3i 210 8 and/or and/or CC cord-019043-cqmqwl3i 210 9 hospital hospital NN cord-019043-cqmqwl3i 210 10 - - HYPH cord-019043-cqmqwl3i 210 11 acquired acquire VBN cord-019043-cqmqwl3i 210 12 ) ) -RRB- cord-019043-cqmqwl3i 211 1 • • NNP cord-019043-cqmqwl3i 212 1 Genitourinary genitourinary JJ cord-019043-cqmqwl3i 212 2 infections infection NNS cord-019043-cqmqwl3i 212 3 ( ( -LRB- cord-019043-cqmqwl3i 212 4 i.e. i.e. FW cord-019043-cqmqwl3i 212 5 , , , cord-019043-cqmqwl3i 212 6 pyocystis pyocystis NN cord-019043-cqmqwl3i 212 7 , , , cord-019043-cqmqwl3i 212 8 pyelonephritis pyelonephritis NN cord-019043-cqmqwl3i 212 9 , , , cord-019043-cqmqwl3i 212 10 perinephric perinephric JJ cord-019043-cqmqwl3i 212 11 infection infection NN cord-019043-cqmqwl3i 212 12 ) ) -RRB- cord-019043-cqmqwl3i 213 1 • • NNP cord-019043-cqmqwl3i 214 1 Cellulitis cellulitis NN cord-019043-cqmqwl3i 214 2 / / SYM cord-019043-cqmqwl3i 214 3 osteomyelitis osteomyelitis NN cord-019043-cqmqwl3i 214 4 • • NN cord-019043-cqmqwl3i 215 1 Gastrointestinal gastrointestinal JJ cord-019043-cqmqwl3i 215 2 infections infection NNS cord-019043-cqmqwl3i 215 3 ( ( -LRB- cord-019043-cqmqwl3i 215 4 i.e. i.e. FW cord-019043-cqmqwl3i 215 5 , , , cord-019043-cqmqwl3i 215 6 Clostridium clostridium NN cord-019043-cqmqwl3i 215 7 difficile difficile NN cord-019043-cqmqwl3i 215 8 , , , cord-019043-cqmqwl3i 215 9 cholangitis cholangitis NN cord-019043-cqmqwl3i 215 10 , , , cord-019043-cqmqwl3i 215 11 hepatitis hepatitis NN cord-019043-cqmqwl3i 215 12 , , , cord-019043-cqmqwl3i 215 13 gastroenteritis gastroenteritis NN cord-019043-cqmqwl3i 215 14 , , , cord-019043-cqmqwl3i 215 15 diverticulitis diverticulitis NN cord-019043-cqmqwl3i 215 16 , , , cord-019043-cqmqwl3i 215 17 cholangitis cholangitis NN cord-019043-cqmqwl3i 215 18 ) ) -RRB- cord-019043-cqmqwl3i 216 1 • • NNP cord-019043-cqmqwl3i 216 2 Central central JJ cord-019043-cqmqwl3i 216 3 nervous nervous JJ cord-019043-cqmqwl3i 216 4 systems system NNS cord-019043-cqmqwl3i 216 5 infections infection NNS cord-019043-cqmqwl3i 217 1 ( ( -LRB- cord-019043-cqmqwl3i 217 2 i.e. i.e. FW cord-019043-cqmqwl3i 217 3 , , , cord-019043-cqmqwl3i 217 4 mucormycosis mucormycosis FW cord-019043-cqmqwl3i 217 5 ) ) -RRB- cord-019043-cqmqwl3i 217 6 Pneumonia pneumonia NN cord-019043-cqmqwl3i 217 7 is be VBZ cord-019043-cqmqwl3i 217 8 a a DT cord-019043-cqmqwl3i 217 9 common common JJ cord-019043-cqmqwl3i 217 10 contributor contributor NN cord-019043-cqmqwl3i 217 11 to to IN cord-019043-cqmqwl3i 217 12 morbidity morbidity NN cord-019043-cqmqwl3i 217 13 and and CC cord-019043-cqmqwl3i 217 14 mortality mortality NN cord-019043-cqmqwl3i 217 15 in in IN cord-019043-cqmqwl3i 217 16 CKD CKD NNP cord-019043-cqmqwl3i 217 17 / / SYM cord-019043-cqmqwl3i 217 18 ESRD ESRD NNP cord-019043-cqmqwl3i 217 19 patients patient NNS cord-019043-cqmqwl3i 217 20 . . . cord-019043-cqmqwl3i 218 1 The the DT cord-019043-cqmqwl3i 218 2 risk risk NN cord-019043-cqmqwl3i 218 3 of of IN cord-019043-cqmqwl3i 218 4 developing develop VBG cord-019043-cqmqwl3i 218 5 pneumonia pneumonia NN cord-019043-cqmqwl3i 218 6 is be VBZ cord-019043-cqmqwl3i 218 7 3 3 CD cord-019043-cqmqwl3i 218 8 - - SYM cord-019043-cqmqwl3i 218 9 5 5 CD cord-019043-cqmqwl3i 218 10 times time NNS cord-019043-cqmqwl3i 218 11 higher high JJR cord-019043-cqmqwl3i 218 12 among among IN cord-019043-cqmqwl3i 218 13 CKD CKD NNP cord-019043-cqmqwl3i 218 14 / / SYM cord-019043-cqmqwl3i 218 15 ESRD ESRD NNP cord-019043-cqmqwl3i 218 16 patients patient NNS cord-019043-cqmqwl3i 218 17 compared compare VBN cord-019043-cqmqwl3i 218 18 with with IN cord-019043-cqmqwl3i 218 19 matched match VBN cord-019043-cqmqwl3i 218 20 population population NN cord-019043-cqmqwl3i 218 21 with with IN cord-019043-cqmqwl3i 218 22 normal normal JJ cord-019043-cqmqwl3i 218 23 kidney kidney NN cord-019043-cqmqwl3i 218 24 function function NN cord-019043-cqmqwl3i 218 25 and and CC cord-019043-cqmqwl3i 218 26 is be VBZ cord-019043-cqmqwl3i 218 27 associated associate VBN cord-019043-cqmqwl3i 218 28 with with IN cord-019043-cqmqwl3i 218 29 a a DT cord-019043-cqmqwl3i 218 30 higher high JJR cord-019043-cqmqwl3i 218 31 likelihood likelihood NN cord-019043-cqmqwl3i 218 32 of of IN cord-019043-cqmqwl3i 218 33 ICU ICU NNP cord-019043-cqmqwl3i 218 34 admission admission NN cord-019043-cqmqwl3i 218 35 and and CC cord-019043-cqmqwl3i 218 36 4 4 CD cord-019043-cqmqwl3i 218 37 - - SYM cord-019043-cqmqwl3i 218 38 6 6 CD cord-019043-cqmqwl3i 218 39 times time NNS cord-019043-cqmqwl3i 218 40 the the DT cord-019043-cqmqwl3i 218 41 total total JJ cord-019043-cqmqwl3i 218 42 duration duration NN cord-019043-cqmqwl3i 218 43 of of IN cord-019043-cqmqwl3i 218 44 hospitalization hospitalization NN cord-019043-cqmqwl3i 218 45 . . . cord-019043-cqmqwl3i 219 1 The the DT cord-019043-cqmqwl3i 219 2 prevalence prevalence NN cord-019043-cqmqwl3i 219 3 of of IN cord-019043-cqmqwl3i 219 4 asymptomatic asymptomatic JJ cord-019043-cqmqwl3i 219 5 pyuria pyuria NNS cord-019043-cqmqwl3i 219 6 among among IN cord-019043-cqmqwl3i 219 7 CKD CKD NNP cord-019043-cqmqwl3i 219 8 / / SYM cord-019043-cqmqwl3i 219 9 ESKD ESKD NNP cord-019043-cqmqwl3i 219 10 patients patient NNS cord-019043-cqmqwl3i 219 11 with with IN cord-019043-cqmqwl3i 219 12 residual residual JJ cord-019043-cqmqwl3i 219 13 urine urine NN cord-019043-cqmqwl3i 219 14 production production NN cord-019043-cqmqwl3i 219 15 is be VBZ cord-019043-cqmqwl3i 219 16 common common JJ cord-019043-cqmqwl3i 219 17 ( ( -LRB- cord-019043-cqmqwl3i 219 18 30 30 CD cord-019043-cqmqwl3i 219 19 - - SYM cord-019043-cqmqwl3i 219 20 40 40 CD cord-019043-cqmqwl3i 219 21 % % NN cord-019043-cqmqwl3i 219 22 ) ) -RRB- cord-019043-cqmqwl3i 219 23 but but CC cord-019043-cqmqwl3i 219 24 of of IN cord-019043-cqmqwl3i 219 25 undeter undeter NN cord-019043-cqmqwl3i 219 26 - - HYPH cord-019043-cqmqwl3i 219 27 mined mine VBN cord-019043-cqmqwl3i 219 28 significance significance NN cord-019043-cqmqwl3i 219 29 , , , cord-019043-cqmqwl3i 219 30 and and CC cord-019043-cqmqwl3i 219 31 the the DT cord-019043-cqmqwl3i 219 32 diagnosis diagnosis NN cord-019043-cqmqwl3i 219 33 of of IN cord-019043-cqmqwl3i 219 34 genitourinary genitourinary JJ cord-019043-cqmqwl3i 219 35 infection infection NN cord-019043-cqmqwl3i 219 36 mandates mandate VBZ cord-019043-cqmqwl3i 219 37 the the DT cord-019043-cqmqwl3i 219 38 presence presence NN cord-019043-cqmqwl3i 219 39 of of IN cord-019043-cqmqwl3i 219 40 a a DT cord-019043-cqmqwl3i 219 41 positive positive JJ cord-019043-cqmqwl3i 219 42 culture culture NN cord-019043-cqmqwl3i 219 43 result result NN cord-019043-cqmqwl3i 219 44 . . . cord-019043-cqmqwl3i 220 1 Indeed indeed RB cord-019043-cqmqwl3i 220 2 , , , cord-019043-cqmqwl3i 220 3 genitourinary genitourinary JJ cord-019043-cqmqwl3i 220 4 infections infection NNS cord-019043-cqmqwl3i 220 5 may may MD cord-019043-cqmqwl3i 220 6 be be VB cord-019043-cqmqwl3i 220 7 the the DT cord-019043-cqmqwl3i 220 8 most most RBS cord-019043-cqmqwl3i 220 9 common common JJ cord-019043-cqmqwl3i 220 10 source source NN cord-019043-cqmqwl3i 220 11 of of IN cord-019043-cqmqwl3i 220 12 nosocomial nosocomial JJ cord-019043-cqmqwl3i 220 13 infection infection NN cord-019043-cqmqwl3i 220 14 occurring occur VBG cord-019043-cqmqwl3i 220 15 in in IN cord-019043-cqmqwl3i 220 16 hospitalized hospitalize VBN cord-019043-cqmqwl3i 220 17 CKD CKD NNP cord-019043-cqmqwl3i 220 18 / / SYM cord-019043-cqmqwl3i 220 19 ESRD ESRD NNP cord-019043-cqmqwl3i 220 20 patients patient NNS cord-019043-cqmqwl3i 220 21 due due JJ cord-019043-cqmqwl3i 220 22 primarily primarily RB cord-019043-cqmqwl3i 220 23 to to IN cord-019043-cqmqwl3i 220 24 urinary urinary JJ cord-019043-cqmqwl3i 220 25 catheterization catheterization NN cord-019043-cqmqwl3i 220 26 . . . cord-019043-cqmqwl3i 221 1 These these DT cord-019043-cqmqwl3i 221 2 sources source NNS cord-019043-cqmqwl3i 221 3 of of IN cord-019043-cqmqwl3i 221 4 infection infection NN cord-019043-cqmqwl3i 221 5 may may MD cord-019043-cqmqwl3i 221 6 predispose predispose VB cord-019043-cqmqwl3i 221 7 to to TO cord-019043-cqmqwl3i 221 8 bloodstream bloodstream VB cord-019043-cqmqwl3i 221 9 infection infection NN cord-019043-cqmqwl3i 221 10 in in IN cord-019043-cqmqwl3i 221 11 susceptible susceptible JJ cord-019043-cqmqwl3i 221 12 CKD CKD NNP cord-019043-cqmqwl3i 221 13 / / SYM cord-019043-cqmqwl3i 221 14 ESRD ESRD NNP cord-019043-cqmqwl3i 221 15 patients patient NNS cord-019043-cqmqwl3i 221 16 and and CC cord-019043-cqmqwl3i 221 17 necessitate necessitate VB cord-019043-cqmqwl3i 221 18 ICU ICU NNP cord-019043-cqmqwl3i 221 19 referral referral NN cord-019043-cqmqwl3i 221 20 for for IN cord-019043-cqmqwl3i 221 21 resuscitation resuscitation NN cord-019043-cqmqwl3i 221 22 and and CC cord-019043-cqmqwl3i 221 23 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 221 24 support support NN cord-019043-cqmqwl3i 221 25 . . . cord-019043-cqmqwl3i 222 1 In in IN cord-019043-cqmqwl3i 222 2 anuric anuric JJ cord-019043-cqmqwl3i 222 3 ESRD ESRD NNP cord-019043-cqmqwl3i 222 4 patients patient NNS cord-019043-cqmqwl3i 222 5 , , , cord-019043-cqmqwl3i 222 6 urinary urinary JJ cord-019043-cqmqwl3i 222 7 catheterization catheterization NN cord-019043-cqmqwl3i 222 8 except except IN cord-019043-cqmqwl3i 222 9 for for IN cord-019043-cqmqwl3i 222 10 diagnostic diagnostic JJ cord-019043-cqmqwl3i 222 11 indications indication NNS cord-019043-cqmqwl3i 222 12 should should MD cord-019043-cqmqwl3i 222 13 be be VB cord-019043-cqmqwl3i 222 14 avoided avoid VBN cord-019043-cqmqwl3i 222 15 . . . cord-019043-cqmqwl3i 223 1 Cellulitis cellulitis NN cord-019043-cqmqwl3i 223 2 is be VBZ cord-019043-cqmqwl3i 223 3 a a DT cord-019043-cqmqwl3i 223 4 common common JJ cord-019043-cqmqwl3i 223 5 precipitant precipitant NN cord-019043-cqmqwl3i 223 6 of of IN cord-019043-cqmqwl3i 223 7 infection infection NN cord-019043-cqmqwl3i 223 8 in in IN cord-019043-cqmqwl3i 223 9 CKD CKD NNP cord-019043-cqmqwl3i 223 10 / / SYM cord-019043-cqmqwl3i 223 11 ESRD ESRD NNP cord-019043-cqmqwl3i 223 12 patients patient NNS cord-019043-cqmqwl3i 223 13 often often RB cord-019043-cqmqwl3i 223 14 predisposed predispose VBN cord-019043-cqmqwl3i 223 15 by by IN cord-019043-cqmqwl3i 223 16 poor poor JJ cord-019043-cqmqwl3i 223 17 peripheral peripheral JJ cord-019043-cqmqwl3i 223 18 circulation circulation NN cord-019043-cqmqwl3i 223 19 ( ( -LRB- cord-019043-cqmqwl3i 223 20 i.e. i.e. FW cord-019043-cqmqwl3i 223 21 , , , cord-019043-cqmqwl3i 223 22 diabetes diabetes NN cord-019043-cqmqwl3i 223 23 mellitus mellitus NN cord-019043-cqmqwl3i 223 24 , , , cord-019043-cqmqwl3i 223 25 peripheral peripheral JJ cord-019043-cqmqwl3i 223 26 vascular vascular JJ cord-019043-cqmqwl3i 223 27 disease disease NN cord-019043-cqmqwl3i 223 28 ) ) -RRB- cord-019043-cqmqwl3i 223 29 coupled couple VBN cord-019043-cqmqwl3i 223 30 with with IN cord-019043-cqmqwl3i 223 31 extravascular extravascular JJ cord-019043-cqmqwl3i 223 32 peripheral peripheral JJ cord-019043-cqmqwl3i 223 33 edema edema NN cord-019043-cqmqwl3i 223 34 or or CC cord-019043-cqmqwl3i 223 35 infection infection NN cord-019043-cqmqwl3i 223 36 introduced introduce VBN cord-019043-cqmqwl3i 223 37 through through IN cord-019043-cqmqwl3i 223 38 repeated repeat VBN cord-019043-cqmqwl3i 223 39 puncture puncture NN cord-019043-cqmqwl3i 223 40 of of IN cord-019043-cqmqwl3i 223 41 the the DT cord-019043-cqmqwl3i 223 42 native native JJ cord-019043-cqmqwl3i 223 43 vascular vascular JJ cord-019043-cqmqwl3i 223 44 access access NN cord-019043-cqmqwl3i 223 45 . . . cord-019043-cqmqwl3i 224 1 By by IN cord-019043-cqmqwl3i 224 2 extension extension NN cord-019043-cqmqwl3i 224 3 , , , cord-019043-cqmqwl3i 224 4 suboptimally suboptimally RB cord-019043-cqmqwl3i 224 5 treated treat VBN cord-019043-cqmqwl3i 224 6 cellulitis cellulitis NN cord-019043-cqmqwl3i 224 7 may may MD cord-019043-cqmqwl3i 224 8 result result VB cord-019043-cqmqwl3i 224 9 in in IN cord-019043-cqmqwl3i 224 10 osteomyelitis osteomyelitis NN cord-019043-cqmqwl3i 224 11 of of IN cord-019043-cqmqwl3i 224 12 adjacent adjacent JJ cord-019043-cqmqwl3i 224 13 bony bony JJ cord-019043-cqmqwl3i 224 14 structures structure NNS cord-019043-cqmqwl3i 224 15 . . . cord-019043-cqmqwl3i 225 1 Severe severe JJ cord-019043-cqmqwl3i 225 2 cellulitis cellulitis NN cord-019043-cqmqwl3i 225 3 may may MD cord-019043-cqmqwl3i 225 4 present present VB cord-019043-cqmqwl3i 225 5 with with IN cord-019043-cqmqwl3i 225 6 bloodstream bloodstream NN cord-019043-cqmqwl3i 225 7 infection infection NN cord-019043-cqmqwl3i 225 8 in in IN cord-019043-cqmqwl3i 225 9 susceptible susceptible JJ cord-019043-cqmqwl3i 225 10 CKD CKD NNP cord-019043-cqmqwl3i 225 11 / / SYM cord-019043-cqmqwl3i 225 12 ESRD ESRD NNP cord-019043-cqmqwl3i 225 13 patients patient NNS cord-019043-cqmqwl3i 225 14 and and CC cord-019043-cqmqwl3i 225 15 prompt prompt VB cord-019043-cqmqwl3i 225 16 ICU ICU NNP cord-019043-cqmqwl3i 225 17 admission admission NN cord-019043-cqmqwl3i 225 18 . . . cord-019043-cqmqwl3i 226 1 The the DT cord-019043-cqmqwl3i 226 2 incidence incidence NN cord-019043-cqmqwl3i 226 3 of of IN cord-019043-cqmqwl3i 226 4 common common JJ cord-019043-cqmqwl3i 226 5 gastrointestinal gastrointestinal JJ cord-019043-cqmqwl3i 226 6 infections infection NNS cord-019043-cqmqwl3i 226 7 in in IN cord-019043-cqmqwl3i 226 8 CKD CKD NNP cord-019043-cqmqwl3i 226 9 / / SYM cord-019043-cqmqwl3i 226 10 ESRD ESRD NNP cord-019043-cqmqwl3i 226 11 patients patient NNS cord-019043-cqmqwl3i 226 12 is be VBZ cord-019043-cqmqwl3i 226 13 similar similar JJ cord-019043-cqmqwl3i 226 14 to to IN cord-019043-cqmqwl3i 226 15 the the DT cord-019043-cqmqwl3i 226 16 general general JJ cord-019043-cqmqwl3i 226 17 population population NN cord-019043-cqmqwl3i 226 18 ; ; : cord-019043-cqmqwl3i 226 19 however however RB cord-019043-cqmqwl3i 226 20 , , , cord-019043-cqmqwl3i 226 21 their -PRON- PRP$ cord-019043-cqmqwl3i 226 22 physiologic physiologic JJ cord-019043-cqmqwl3i 226 23 reserve reserve NN cord-019043-cqmqwl3i 226 24 to to TO cord-019043-cqmqwl3i 226 25 withstand withstand VB cord-019043-cqmqwl3i 226 26 these these DT cord-019043-cqmqwl3i 226 27 infections infection NNS cord-019043-cqmqwl3i 226 28 may may MD cord-019043-cqmqwl3i 226 29 be be VB cord-019043-cqmqwl3i 226 30 severely severely RB cord-019043-cqmqwl3i 226 31 blunted blunt VBN cord-019043-cqmqwl3i 226 32 and and CC cord-019043-cqmqwl3i 226 33 further far RBR cord-019043-cqmqwl3i 226 34 predispose predispose VB cord-019043-cqmqwl3i 226 35 to to IN cord-019043-cqmqwl3i 226 36 added add VBN cord-019043-cqmqwl3i 226 37 morbidity morbidity NN cord-019043-cqmqwl3i 226 38 . . . cord-019043-cqmqwl3i 227 1 The the DT cord-019043-cqmqwl3i 227 2 exceptions exception NNS cord-019043-cqmqwl3i 227 3 include include VBP cord-019043-cqmqwl3i 227 4 susceptibility susceptibility NN cord-019043-cqmqwl3i 227 5 to to IN cord-019043-cqmqwl3i 227 6 infectious infectious JJ cord-019043-cqmqwl3i 227 7 hepatitis hepatitis NN cord-019043-cqmqwl3i 227 8 ( ( -LRB- cord-019043-cqmqwl3i 227 9 hepatitis hepatitis NNP cord-019043-cqmqwl3i 227 10 B B NNP cord-019043-cqmqwl3i 227 11 and and CC cord-019043-cqmqwl3i 227 12 C C NNP cord-019043-cqmqwl3i 227 13 virus virus NN cord-019043-cqmqwl3i 227 14 ) ) -RRB- cord-019043-cqmqwl3i 227 15 , , , cord-019043-cqmqwl3i 227 16 peritonitis peritonitis NN cord-019043-cqmqwl3i 227 17 among among IN cord-019043-cqmqwl3i 227 18 patients patient NNS cord-019043-cqmqwl3i 227 19 receiving receive VBG cord-019043-cqmqwl3i 227 20 peritoneal peritoneal JJ cord-019043-cqmqwl3i 227 21 dialysis dialysis NN cord-019043-cqmqwl3i 227 22 , , , cord-019043-cqmqwl3i 227 23 and and CC cord-019043-cqmqwl3i 227 24 Clostridium clostridium NN cord-019043-cqmqwl3i 227 25 difficile difficile NN cord-019043-cqmqwl3i 227 26 colitis colitis NN cord-019043-cqmqwl3i 227 27 due due JJ cord-019043-cqmqwl3i 227 28 to to IN cord-019043-cqmqwl3i 227 29 frequent frequent JJ cord-019043-cqmqwl3i 227 30 antimicrobial antimicrobial JJ cord-019043-cqmqwl3i 227 31 exposure exposure NN cord-019043-cqmqwl3i 227 32 and and CC cord-019043-cqmqwl3i 227 33 interaction interaction NN cord-019043-cqmqwl3i 227 34 with with IN cord-019043-cqmqwl3i 227 35 health health NN cord-019043-cqmqwl3i 227 36 services service NNS cord-019043-cqmqwl3i 227 37 . . . cord-019043-cqmqwl3i 228 1 Sepsis sepsis NN cord-019043-cqmqwl3i 228 2 is be VBZ cord-019043-cqmqwl3i 228 3 defined define VBN cord-019043-cqmqwl3i 228 4 as as IN cord-019043-cqmqwl3i 228 5 the the DT cord-019043-cqmqwl3i 228 6 presence presence NN cord-019043-cqmqwl3i 228 7 of of IN cord-019043-cqmqwl3i 228 8 infection infection NN cord-019043-cqmqwl3i 228 9 together together RB cord-019043-cqmqwl3i 228 10 with with IN cord-019043-cqmqwl3i 228 11 systemic systemic JJ cord-019043-cqmqwl3i 228 12 manifestations manifestation NNS cord-019043-cqmqwl3i 228 13 of of IN cord-019043-cqmqwl3i 228 14 inflammation inflammation NN cord-019043-cqmqwl3i 228 15 . . . cord-019043-cqmqwl3i 229 1 Severe severe JJ cord-019043-cqmqwl3i 229 2 sepsis sepsis NN cord-019043-cqmqwl3i 229 3 is be VBZ cord-019043-cqmqwl3i 229 4 defined define VBN cord-019043-cqmqwl3i 229 5 as as IN cord-019043-cqmqwl3i 229 6 sepsis sepsis NN cord-019043-cqmqwl3i 229 7 plus plus CC cord-019043-cqmqwl3i 229 8 sepsis sepsis NN cord-019043-cqmqwl3i 229 9 - - HYPH cord-019043-cqmqwl3i 229 10 induced induce VBN cord-019043-cqmqwl3i 229 11 organ organ NN cord-019043-cqmqwl3i 229 12 dysfunction dysfunction NN cord-019043-cqmqwl3i 229 13 or or CC cord-019043-cqmqwl3i 229 14 tissue tissue NN cord-019043-cqmqwl3i 229 15 hypoperfusion hypoperfusion NN cord-019043-cqmqwl3i 229 16 , , , cord-019043-cqmqwl3i 229 17 and and CC cord-019043-cqmqwl3i 229 18 septic septic JJ cord-019043-cqmqwl3i 229 19 shock shock NN cord-019043-cqmqwl3i 229 20 is be VBZ cord-019043-cqmqwl3i 229 21 defined define VBN cord-019043-cqmqwl3i 229 22 as as IN cord-019043-cqmqwl3i 229 23 severe severe JJ cord-019043-cqmqwl3i 229 24 sepsis sepsis NN cord-019043-cqmqwl3i 229 25 plus plus CC cord-019043-cqmqwl3i 229 26 hypotension hypotension NN cord-019043-cqmqwl3i 229 27 not not RB cord-019043-cqmqwl3i 229 28 reversed reverse VBD cord-019043-cqmqwl3i 229 29 with with IN cord-019043-cqmqwl3i 229 30 fluid fluid JJ cord-019043-cqmqwl3i 229 31 resuscitation resuscitation NN cord-019043-cqmqwl3i 229 32 [ [ -LRB- cord-019043-cqmqwl3i 229 33 9 9 CD cord-019043-cqmqwl3i 229 34 ] ] -RRB- cord-019043-cqmqwl3i 229 35 . . . cord-019043-cqmqwl3i 230 1 The the DT cord-019043-cqmqwl3i 230 2 diagnostic diagnostic JJ cord-019043-cqmqwl3i 230 3 criteria criterion NNS cord-019043-cqmqwl3i 230 4 for for IN cord-019043-cqmqwl3i 230 5 sepsis sepsis NN cord-019043-cqmqwl3i 230 6 and and CC cord-019043-cqmqwl3i 230 7 sepsis sepsis NN cord-019043-cqmqwl3i 230 8 - - HYPH cord-019043-cqmqwl3i 230 9 related relate VBN cord-019043-cqmqwl3i 230 10 organ organ NN cord-019043-cqmqwl3i 230 11 dysfunction dysfunction NN cord-019043-cqmqwl3i 230 12 are be VBP cord-019043-cqmqwl3i 230 13 shown show VBN cord-019043-cqmqwl3i 230 14 in in IN cord-019043-cqmqwl3i 230 15 Box Box NNP cord-019043-cqmqwl3i 230 16 32.5 32.5 CD cord-019043-cqmqwl3i 230 17 . . . cord-019043-cqmqwl3i 231 1 It -PRON- PRP cord-019043-cqmqwl3i 231 2 is be VBZ cord-019043-cqmqwl3i 231 3 important important JJ cord-019043-cqmqwl3i 231 4 to to TO cord-019043-cqmqwl3i 231 5 recognize recognize VB cord-019043-cqmqwl3i 231 6 that that IN cord-019043-cqmqwl3i 231 7 many many JJ cord-019043-cqmqwl3i 231 8 of of IN cord-019043-cqmqwl3i 231 9 these these DT cord-019043-cqmqwl3i 231 10 criteria criterion NNS cord-019043-cqmqwl3i 231 11 may may MD cord-019043-cqmqwl3i 231 12 be be VB cord-019043-cqmqwl3i 231 13 modified modify VBN cord-019043-cqmqwl3i 231 14 due due IN cord-019043-cqmqwl3i 231 15 to to IN cord-019043-cqmqwl3i 231 16 CKD CKD NNP cord-019043-cqmqwl3i 231 17 / / SYM cord-019043-cqmqwl3i 231 18 ESRD ESRD NNP cord-019043-cqmqwl3i 231 19 and and CC cord-019043-cqmqwl3i 231 20 its -PRON- PRP$ cord-019043-cqmqwl3i 231 21 treatment treatment NN cord-019043-cqmqwl3i 231 22 alone alone RB cord-019043-cqmqwl3i 231 23 ( ( -LRB- cord-019043-cqmqwl3i 231 24 i.e. i.e. FW cord-019043-cqmqwl3i 231 25 , , , cord-019043-cqmqwl3i 231 26 dialysis dialysis NN cord-019043-cqmqwl3i 231 27 - - HYPH cord-019043-cqmqwl3i 231 28 induced induce VBN cord-019043-cqmqwl3i 231 29 endotoxemia endotoxemia NN cord-019043-cqmqwl3i 231 30 or or CC cord-019043-cqmqwl3i 231 31 hypotension hypotension NN cord-019043-cqmqwl3i 231 32 ) ) -RRB- cord-019043-cqmqwl3i 231 33 or or CC cord-019043-cqmqwl3i 231 34 due due JJ cord-019043-cqmqwl3i 231 35 to to IN cord-019043-cqmqwl3i 231 36 concomitant concomitant JJ cord-019043-cqmqwl3i 231 37 comorbid comorbid NN cord-019043-cqmqwl3i 231 38 disease disease NN cord-019043-cqmqwl3i 231 39 ( ( -LRB- cord-019043-cqmqwl3i 231 40 i.e. i.e. FW cord-019043-cqmqwl3i 231 41 , , , cord-019043-cqmqwl3i 231 42 reduced reduce VBN cord-019043-cqmqwl3i 231 43 cardiac cardiac NN cord-019043-cqmqwl3i 231 44 reserve reserve NN cord-019043-cqmqwl3i 231 45 due due IN cord-019043-cqmqwl3i 231 46 to to IN cord-019043-cqmqwl3i 231 47 cardiorenal cardiorenal JJ cord-019043-cqmqwl3i 231 48 syndrome syndrome NN cord-019043-cqmqwl3i 231 49 , , , cord-019043-cqmqwl3i 231 50 autonomic autonomic JJ cord-019043-cqmqwl3i 231 51 dysfunction dysfunction NN cord-019043-cqmqwl3i 231 52 due due IN cord-019043-cqmqwl3i 231 53 to to IN cord-019043-cqmqwl3i 231 54 diabetes diabetes NN cord-019043-cqmqwl3i 231 55 mellitus mellitus NN cord-019043-cqmqwl3i 231 56 ) ) -RRB- cord-019043-cqmqwl3i 231 57 , , , cord-019043-cqmqwl3i 231 58 drug drug NN cord-019043-cqmqwl3i 231 59 therapy therapy NN cord-019043-cqmqwl3i 231 60 ( ( -LRB- cord-019043-cqmqwl3i 231 61 i.e. i.e. FW cord-019043-cqmqwl3i 231 62 , , , cord-019043-cqmqwl3i 231 63 β β NN cord-019043-cqmqwl3i 231 64 - - HYPH cord-019043-cqmqwl3i 231 65 blockers blocker NNS cord-019043-cqmqwl3i 231 66 , , , cord-019043-cqmqwl3i 231 67 Coumadin Coumadin NNP cord-019043-cqmqwl3i 231 68 ) ) -RRB- cord-019043-cqmqwl3i 231 69 , , , cord-019043-cqmqwl3i 231 70 or or CC cord-019043-cqmqwl3i 231 71 not not RB cord-019043-cqmqwl3i 231 72 being be VBG cord-019043-cqmqwl3i 231 73 applicable applicable JJ cord-019043-cqmqwl3i 231 74 ( ( -LRB- cord-019043-cqmqwl3i 231 75 i.e. i.e. FW cord-019043-cqmqwl3i 231 76 , , , cord-019043-cqmqwl3i 231 77 serum serum NN cord-019043-cqmqwl3i 231 78 creatinine creatinine NN cord-019043-cqmqwl3i 231 79 elevation elevation NN cord-019043-cqmqwl3i 231 80 or or CC cord-019043-cqmqwl3i 231 81 oliguria oliguria NNP cord-019043-cqmqwl3i 231 82 in in IN cord-019043-cqmqwl3i 231 83 anuric anuric JJ cord-019043-cqmqwl3i 231 84 ESKD ESKD NNP cord-019043-cqmqwl3i 231 85 ) ) -RRB- cord-019043-cqmqwl3i 231 86 . . . cord-019043-cqmqwl3i 232 1 The the DT cord-019043-cqmqwl3i 232 2 general general JJ cord-019043-cqmqwl3i 232 3 principles principle NNS cord-019043-cqmqwl3i 232 4 and and CC cord-019043-cqmqwl3i 232 5 initial initial JJ cord-019043-cqmqwl3i 232 6 management management NN cord-019043-cqmqwl3i 232 7 of of IN cord-019043-cqmqwl3i 232 8 sepsis sepsis NN cord-019043-cqmqwl3i 232 9 in in IN cord-019043-cqmqwl3i 232 10 CKD CKD NNP cord-019043-cqmqwl3i 232 11 / / SYM cord-019043-cqmqwl3i 232 12 ESRD ESRD NNP cord-019043-cqmqwl3i 232 13 patients patient NNS cord-019043-cqmqwl3i 232 14 are be VBP cord-019043-cqmqwl3i 232 15 similar similar JJ cord-019043-cqmqwl3i 232 16 to to IN cord-019043-cqmqwl3i 232 17 the the DT cord-019043-cqmqwl3i 232 18 acute acute JJ cord-019043-cqmqwl3i 232 19 resuscitation resuscitation NN cord-019043-cqmqwl3i 232 20 of of IN cord-019043-cqmqwl3i 232 21 patients patient NNS cord-019043-cqmqwl3i 232 22 with with IN cord-019043-cqmqwl3i 232 23 suspected suspect VBN cord-019043-cqmqwl3i 232 24 sepsis sepsis NN cord-019043-cqmqwl3i 232 25 and and CC cord-019043-cqmqwl3i 232 26 AKI AKI NNP cord-019043-cqmqwl3i 232 27 without without IN cord-019043-cqmqwl3i 232 28 kidney kidney NN cord-019043-cqmqwl3i 232 29 disease disease NN cord-019043-cqmqwl3i 232 30 ( ( -LRB- cord-019043-cqmqwl3i 232 31 Boxes box NNS cord-019043-cqmqwl3i 232 32 32.6 32.6 CD cord-019043-cqmqwl3i 232 33 and and CC cord-019043-cqmqwl3i 232 34 32.7 32.7 CD cord-019043-cqmqwl3i 232 35 ) ) -RRB- cord-019043-cqmqwl3i 232 36 . . . cord-019043-cqmqwl3i 233 1 Early early RB cord-019043-cqmqwl3i 233 2 " " `` cord-019043-cqmqwl3i 233 3 bundled bundle VBN cord-019043-cqmqwl3i 233 4 " " '' cord-019043-cqmqwl3i 233 5 resuscitation resuscitation NN cord-019043-cqmqwl3i 233 6 coupled couple VBN cord-019043-cqmqwl3i 233 7 with with IN cord-019043-cqmqwl3i 233 8 prompt prompt JJ cord-019043-cqmqwl3i 233 9 broad broad JJ cord-019043-cqmqwl3i 233 10 - - HYPH cord-019043-cqmqwl3i 233 11 spectrum spectrum NN cord-019043-cqmqwl3i 233 12 antimicrobial antimicrobial NN cord-019043-cqmqwl3i 233 13 therapy therapy NN cord-019043-cqmqwl3i 233 14 and and CC cord-019043-cqmqwl3i 233 15 source source NN cord-019043-cqmqwl3i 233 16 control control NN cord-019043-cqmqwl3i 233 17 should should MD cord-019043-cqmqwl3i 233 18 be be VB cord-019043-cqmqwl3i 233 19 established establish VBN cord-019043-cqmqwl3i 233 20 in in IN cord-019043-cqmqwl3i 233 21 accordance accordance NN cord-019043-cqmqwl3i 233 22 with with IN cord-019043-cqmqwl3i 233 23 clinical clinical JJ cord-019043-cqmqwl3i 233 24 practice practice NN cord-019043-cqmqwl3i 233 25 guidelines guideline NNS cord-019043-cqmqwl3i 233 26 [ [ -LRB- cord-019043-cqmqwl3i 233 27 9 9 CD cord-019043-cqmqwl3i 233 28 ] ] -RRB- cord-019043-cqmqwl3i 233 29 . . . cord-019043-cqmqwl3i 234 1 If if IN cord-019043-cqmqwl3i 234 2 there there EX cord-019043-cqmqwl3i 234 3 is be VBZ cord-019043-cqmqwl3i 234 4 suspicion suspicion NN cord-019043-cqmqwl3i 234 5 that that IN cord-019043-cqmqwl3i 234 6 the the DT cord-019043-cqmqwl3i 234 7 source source NN cord-019043-cqmqwl3i 234 8 of of IN cord-019043-cqmqwl3i 234 9 sepsis sepsis NN cord-019043-cqmqwl3i 234 10 is be VBZ cord-019043-cqmqwl3i 234 11 a a DT cord-019043-cqmqwl3i 234 12 vascular vascular JJ cord-019043-cqmqwl3i 234 13 access access NN cord-019043-cqmqwl3i 234 14 catheter catheter NN cord-019043-cqmqwl3i 234 15 , , , cord-019043-cqmqwl3i 234 16 this this DT cord-019043-cqmqwl3i 234 17 should should MD cord-019043-cqmqwl3i 234 18 be be VB cord-019043-cqmqwl3i 234 19 promptly promptly RB cord-019043-cqmqwl3i 234 20 removed remove VBN cord-019043-cqmqwl3i 234 21 once once RB cord-019043-cqmqwl3i 234 22 further further JJ cord-019043-cqmqwl3i 234 23 central central JJ cord-019043-cqmqwl3i 234 24 venous venous JJ cord-019043-cqmqwl3i 234 25 access access NN cord-019043-cqmqwl3i 234 26 has have VBZ cord-019043-cqmqwl3i 234 27 been be VBN cord-019043-cqmqwl3i 234 28 confirmed confirm VBN cord-019043-cqmqwl3i 234 29 . . . cord-019043-cqmqwl3i 235 1 Acute acute JJ cord-019043-cqmqwl3i 235 2 kidney kidney NN cord-019043-cqmqwl3i 235 3 injury injury NN cord-019043-cqmqwl3i 235 4 ( ( -LRB- cord-019043-cqmqwl3i 235 5 AKI AKI NNP cord-019043-cqmqwl3i 235 6 ) ) -RRB- cord-019043-cqmqwl3i 235 7 is be VBZ cord-019043-cqmqwl3i 235 8 a a DT cord-019043-cqmqwl3i 235 9 common common JJ cord-019043-cqmqwl3i 235 10 complication complication NN cord-019043-cqmqwl3i 235 11 encountered encounter VBN cord-019043-cqmqwl3i 235 12 in in IN cord-019043-cqmqwl3i 235 13 hospitalized hospitalize VBN cord-019043-cqmqwl3i 235 14 patients patient NNS cord-019043-cqmqwl3i 235 15 , , , cord-019043-cqmqwl3i 235 16 particularly particularly RB cord-019043-cqmqwl3i 235 17 in in IN cord-019043-cqmqwl3i 235 18 the the DT cord-019043-cqmqwl3i 235 19 setting setting NN cord-019043-cqmqwl3i 235 20 of of IN cord-019043-cqmqwl3i 235 21 critical critical JJ cord-019043-cqmqwl3i 235 22 illness illness NN cord-019043-cqmqwl3i 235 23 , , , cord-019043-cqmqwl3i 235 24 occurring occur VBG cord-019043-cqmqwl3i 235 25 in in IN cord-019043-cqmqwl3i 235 26 up up IN cord-019043-cqmqwl3i 235 27 to to TO cord-019043-cqmqwl3i 235 28 two two CD cord-019043-cqmqwl3i 235 29 - - HYPH cord-019043-cqmqwl3i 235 30 thirds third NNS cord-019043-cqmqwl3i 235 31 of of IN cord-019043-cqmqwl3i 235 32 patients patient NNS cord-019043-cqmqwl3i 235 33 [ [ -LRB- cord-019043-cqmqwl3i 235 34 13 13 CD cord-019043-cqmqwl3i 235 35 ] ] -RRB- cord-019043-cqmqwl3i 235 36 . . . cord-019043-cqmqwl3i 236 1 Recently recently RB cord-019043-cqmqwl3i 236 2 , , , cord-019043-cqmqwl3i 236 3 the the DT cord-019043-cqmqwl3i 236 4 KDIGO KDIGO NNP cord-019043-cqmqwl3i 236 5 Clinical Clinical NNP cord-019043-cqmqwl3i 236 6 Practice Practice NNP cord-019043-cqmqwl3i 236 7 Guidelines Guidelines NNPS cord-019043-cqmqwl3i 236 8 for for IN cord-019043-cqmqwl3i 236 9 Acute acute JJ cord-019043-cqmqwl3i 236 10 Kidney Kidney NNP cord-019043-cqmqwl3i 236 11 Injury Injury NNP cord-019043-cqmqwl3i 236 12 published publish VBN cord-019043-cqmqwl3i 236 13 updated update VBN cord-019043-cqmqwl3i 236 14 consensus consensus NN cord-019043-cqmqwl3i 236 15 criteria criterion NNS cord-019043-cqmqwl3i 236 16 for for IN cord-019043-cqmqwl3i 236 17 the the DT cord-019043-cqmqwl3i 236 18 diagnosis diagnosis NN cord-019043-cqmqwl3i 236 19 and and CC cord-019043-cqmqwl3i 236 20 staging staging NN cord-019043-cqmqwl3i 236 21 of of IN cord-019043-cqmqwl3i 236 22 AKI AKI NNP cord-019043-cqmqwl3i 236 23 [ [ -LRB- cord-019043-cqmqwl3i 236 24 11 11 CD cord-019043-cqmqwl3i 236 25 ] ] -RRB- cord-019043-cqmqwl3i 237 1 ( ( -LRB- cord-019043-cqmqwl3i 237 2 Table table NN cord-019043-cqmqwl3i 237 3 32 32 CD cord-019043-cqmqwl3i 237 4 .5 .5 CD cord-019043-cqmqwl3i 237 5 ) ) -RRB- cord-019043-cqmqwl3i 237 6 . . . cord-019043-cqmqwl3i 238 1 These these DT cord-019043-cqmqwl3i 238 2 criteria criterion NNS cord-019043-cqmqwl3i 238 3 do do VBP cord-019043-cqmqwl3i 238 4 not not RB cord-019043-cqmqwl3i 238 5 currently currently RB cord-019043-cqmqwl3i 238 6 integrate integrate VB cord-019043-cqmqwl3i 238 7 evolving evolve VBG cord-019043-cqmqwl3i 238 8 novel novel JJ cord-019043-cqmqwl3i 238 9 diagnostic diagnostic JJ cord-019043-cqmqwl3i 238 10 biomarkers biomarker NNS cord-019043-cqmqwl3i 238 11 specific specific JJ cord-019043-cqmqwl3i 238 12 for for IN cord-019043-cqmqwl3i 238 13 kidney kidney NN cord-019043-cqmqwl3i 238 14 damage damage NN cord-019043-cqmqwl3i 238 15 ( ( -LRB- cord-019043-cqmqwl3i 238 16 i.e. i.e. FW cord-019043-cqmqwl3i 238 17 , , , cord-019043-cqmqwl3i 238 18 NGAL NGAL NNP cord-019043-cqmqwl3i 238 19 , , , cord-019043-cqmqwl3i 238 20 KIM-1 KIM-1 NNP cord-019043-cqmqwl3i 238 21 , , , cord-019043-cqmqwl3i 238 22 IL-18 IL-18 NNP cord-019043-cqmqwl3i 238 23 , , , cord-019043-cqmqwl3i 238 24 L L NNP cord-019043-cqmqwl3i 238 25 - - HYPH cord-019043-cqmqwl3i 238 26 FABP FABP NNP cord-019043-cqmqwl3i 238 27 ) ) -RRB- cord-019043-cqmqwl3i 238 28 . . . cord-019043-cqmqwl3i 239 1 Yet yet CC cord-019043-cqmqwl3i 239 2 , , , cord-019043-cqmqwl3i 239 3 these these DT cord-019043-cqmqwl3i 239 4 novel novel JJ cord-019043-cqmqwl3i 239 5 biomarkers biomarker NNS cord-019043-cqmqwl3i 239 6 show show VBP cord-019043-cqmqwl3i 239 7 significant significant JJ cord-019043-cqmqwl3i 239 8 promise promise NN cord-019043-cqmqwl3i 239 9 to to TO cord-019043-cqmqwl3i 239 10 improve improve VB cord-019043-cqmqwl3i 239 11 the the DT cord-019043-cqmqwl3i 239 12 capacity capacity NN cord-019043-cqmqwl3i 239 13 for for IN cord-019043-cqmqwl3i 239 14 early early JJ cord-019043-cqmqwl3i 239 15 diagnosis diagnosis NN cord-019043-cqmqwl3i 239 16 , , , cord-019043-cqmqwl3i 239 17 prognostication prognostication NN cord-019043-cqmqwl3i 239 18 , , , cord-019043-cqmqwl3i 239 19 and and CC cord-019043-cqmqwl3i 239 20 informed informed JJ cord-019043-cqmqwl3i 239 21 decision decision NN cord-019043-cqmqwl3i 239 22 - - HYPH cord-019043-cqmqwl3i 239 23 making making NN cord-019043-cqmqwl3i 239 24 in in IN cord-019043-cqmqwl3i 239 25 AKI AKI NNP cord-019043-cqmqwl3i 239 26 by by IN cord-019043-cqmqwl3i 239 27 helping help VBG cord-019043-cqmqwl3i 239 28 to to TO cord-019043-cqmqwl3i 239 29 better better RB cord-019043-cqmqwl3i 239 30 discriminate discriminate VB cord-019043-cqmqwl3i 239 31 etiology etiology NN cord-019043-cqmqwl3i 239 32 of of IN cord-019043-cqmqwl3i 239 33 loss loss NN cord-019043-cqmqwl3i 239 34 of of IN cord-019043-cqmqwl3i 239 35 kidney kidney NN cord-019043-cqmqwl3i 239 36 function function NN cord-019043-cqmqwl3i 239 37 ( ( -LRB- cord-019043-cqmqwl3i 239 38 i.e. i.e. FW cord-019043-cqmqwl3i 239 39 , , , cord-019043-cqmqwl3i 239 40 AKI AKI NNP cord-019043-cqmqwl3i 239 41 vs. vs. FW cord-019043-cqmqwl3i 239 42 CKD CKD NNP cord-019043-cqmqwl3i 239 43 ) ) -RRB- cord-019043-cqmqwl3i 239 44 , , , cord-019043-cqmqwl3i 239 45 risk risk NN cord-019043-cqmqwl3i 239 46 of of IN cord-019043-cqmqwl3i 239 47 worsening worsen VBG cord-019043-cqmqwl3i 239 48 AKI AKI NNP cord-019043-cqmqwl3i 239 49 and and CC cord-019043-cqmqwl3i 239 50 need need NN cord-019043-cqmqwl3i 239 51 for for IN cord-019043-cqmqwl3i 239 52 RRT RRT NNP cord-019043-cqmqwl3i 239 53 , , , cord-019043-cqmqwl3i 239 54 and and CC cord-019043-cqmqwl3i 239 55 longterm longterm JJ cord-019043-cqmqwl3i 239 56 risk risk NN cord-019043-cqmqwl3i 239 57 of of IN cord-019043-cqmqwl3i 239 58 CKD CKD NNP cord-019043-cqmqwl3i 239 59 . . . cord-019043-cqmqwl3i 240 1 Development development NN cord-019043-cqmqwl3i 240 2 of of IN cord-019043-cqmqwl3i 240 3 AKI AKI NNP cord-019043-cqmqwl3i 240 4 portends portend VBZ cord-019043-cqmqwl3i 240 5 a a DT cord-019043-cqmqwl3i 240 6 worse bad JJR cord-019043-cqmqwl3i 240 7 clinical clinical JJ cord-019043-cqmqwl3i 240 8 prognosis prognosis NN cord-019043-cqmqwl3i 240 9 in in IN cord-019043-cqmqwl3i 240 10 critically critically RB cord-019043-cqmqwl3i 240 11 ill ill JJ cord-019043-cqmqwl3i 240 12 patients patient NNS cord-019043-cqmqwl3i 240 13 and and CC cord-019043-cqmqwl3i 240 14 predicts predict VBZ cord-019043-cqmqwl3i 240 15 such such JJ cord-019043-cqmqwl3i 240 16 adverse adverse JJ cord-019043-cqmqwl3i 240 17 outcomes outcome NNS cord-019043-cqmqwl3i 240 18 as as IN cord-019043-cqmqwl3i 240 19 need need NN cord-019043-cqmqwl3i 240 20 for for IN cord-019043-cqmqwl3i 240 21 renal renal JJ cord-019043-cqmqwl3i 240 22 replacement replacement NN cord-019043-cqmqwl3i 240 23 therapy therapy NN cord-019043-cqmqwl3i 240 24 ( ( -LRB- cord-019043-cqmqwl3i 240 25 RRT RRT NNP cord-019043-cqmqwl3i 240 26 ) ) -RRB- cord-019043-cqmqwl3i 240 27 , , , cord-019043-cqmqwl3i 240 28 prolonged prolong VBN cord-019043-cqmqwl3i 240 29 ICU ICU NNP cord-019043-cqmqwl3i 240 30 and and CC cord-019043-cqmqwl3i 240 31 hospital hospital NN cord-019043-cqmqwl3i 240 32 stay stay NN cord-019043-cqmqwl3i 240 33 , , , cord-019043-cqmqwl3i 240 34 and and CC cord-019043-cqmqwl3i 240 35 increased increase VBN cord-019043-cqmqwl3i 240 36 mortality mortality NN cord-019043-cqmqwl3i 240 37 risk risk NN cord-019043-cqmqwl3i 240 38 [ [ -LRB- cord-019043-cqmqwl3i 240 39 14 14 CD cord-019043-cqmqwl3i 240 40 ] ] -RRB- cord-019043-cqmqwl3i 240 41 . . . cord-019043-cqmqwl3i 241 1 Importantly importantly RB cord-019043-cqmqwl3i 241 2 , , , cord-019043-cqmqwl3i 241 3 for for IN cord-019043-cqmqwl3i 241 4 the the DT cord-019043-cqmqwl3i 241 5 CKD CKD NNP cord-019043-cqmqwl3i 241 6 patients patient NNS cord-019043-cqmqwl3i 241 7 developing develop VBG cord-019043-cqmqwl3i 241 8 acute acute JJ cord-019043-cqmqwl3i 241 9 - - HYPH cord-019043-cqmqwl3i 241 10 on on IN cord-019043-cqmqwl3i 241 11 - - HYPH cord-019043-cqmqwl3i 241 12 chronic chronic NN cord-019043-cqmqwl3i 241 13 AKI AKI NNP cord-019043-cqmqwl3i 241 14 , , , cord-019043-cqmqwl3i 241 15 the the DT cord-019043-cqmqwl3i 241 16 risk risk NN cord-019043-cqmqwl3i 241 17 of of IN cord-019043-cqmqwl3i 241 18 worsened worsen VBN cord-019043-cqmqwl3i 241 19 CKD CKD NNP cord-019043-cqmqwl3i 241 20 and and CC cord-019043-cqmqwl3i 241 21 accelerated accelerate VBN cord-019043-cqmqwl3i 241 22 decline decline NN cord-019043-cqmqwl3i 241 23 in in IN cord-019043-cqmqwl3i 241 24 function function NN cord-019043-cqmqwl3i 241 25 toward toward IN cord-019043-cqmqwl3i 241 26 ESRD ESRD NNP cord-019043-cqmqwl3i 241 27 is be VBZ cord-019043-cqmqwl3i 241 28 increased increase VBN cord-019043-cqmqwl3i 241 29 several several JJ cord-019043-cqmqwl3i 241 30 fold fold NN cord-019043-cqmqwl3i 241 31 . . . cord-019043-cqmqwl3i 242 1 More More JJR cord-019043-cqmqwl3i 242 2 severe severe JJ cord-019043-cqmqwl3i 242 3 forms form NNS cord-019043-cqmqwl3i 242 4 of of IN cord-019043-cqmqwl3i 242 5 AKI AKI NNP cord-019043-cqmqwl3i 242 6 are be VBP cord-019043-cqmqwl3i 242 7 also also RB cord-019043-cqmqwl3i 242 8 associated associate VBN cord-019043-cqmqwl3i 242 9 with with IN cord-019043-cqmqwl3i 242 10 gradient gradient NN cord-019043-cqmqwl3i 242 11 increases increase NNS cord-019043-cqmqwl3i 242 12 in in IN cord-019043-cqmqwl3i 242 13 the the DT cord-019043-cqmqwl3i 242 14 risk risk NN cord-019043-cqmqwl3i 242 15 of of IN cord-019043-cqmqwl3i 242 16 death death NN cord-019043-cqmqwl3i 242 17 and/or and/or CC cord-019043-cqmqwl3i 242 18 non non JJ cord-019043-cqmqwl3i 242 19 - - JJ cord-019043-cqmqwl3i 242 20 recovery recovery NN cord-019043-cqmqwl3i 242 21 of of IN cord-019043-cqmqwl3i 242 22 kidney kidney NN cord-019043-cqmqwl3i 242 23 function function NN cord-019043-cqmqwl3i 242 24 and and CC cord-019043-cqmqwl3i 242 25 dialysis dialysis NN cord-019043-cqmqwl3i 242 26 dependence dependence NN cord-019043-cqmqwl3i 242 27 [ [ -LRB- cord-019043-cqmqwl3i 242 28 15 15 CD cord-019043-cqmqwl3i 242 29 ] ] -RRB- cord-019043-cqmqwl3i 242 30 . . . cord-019043-cqmqwl3i 243 1 Infection infection NN cord-019043-cqmqwl3i 243 2 ( ( -LRB- cord-019043-cqmqwl3i 243 3 confirmed confirm VBN cord-019043-cqmqwl3i 243 4 or or CC cord-019043-cqmqwl3i 243 5 suspected suspect VBN cord-019043-cqmqwl3i 243 6 ) ) -RRB- cord-019043-cqmqwl3i 243 7 plus plus CC cord-019043-cqmqwl3i 243 8 some some DT cord-019043-cqmqwl3i 243 9 of of IN cord-019043-cqmqwl3i 243 10 the the DT cord-019043-cqmqwl3i 243 11 following follow VBG cord-019043-cqmqwl3i 243 12 criteria criterion NNS cord-019043-cqmqwl3i 243 13 : : : cord-019043-cqmqwl3i 243 14 General general JJ cord-019043-cqmqwl3i 243 15 variables variable NNS cord-019043-cqmqwl3i 243 16 Fever fever NN cord-019043-cqmqwl3i 243 17 ( ( -LRB- cord-019043-cqmqwl3i 243 18 > > NFP cord-019043-cqmqwl3i 243 19 38.3 38.3 CD cord-019043-cqmqwl3i 243 20 ° ° NN cord-019043-cqmqwl3i 243 21 C C NNP cord-019043-cqmqwl3i 243 22 ) ) -RRB- cord-019043-cqmqwl3i 243 23 or or CC cord-019043-cqmqwl3i 243 24 hypothermia hypothermia NN cord-019043-cqmqwl3i 243 25 ( ( -LRB- cord-019043-cqmqwl3i 243 26 < < NNP cord-019043-cqmqwl3i 243 27 36.0 36.0 CD cord-019043-cqmqwl3i 243 28 ° ° NN cord-019043-cqmqwl3i 243 29 C C NNP cord-019043-cqmqwl3i 243 30 ) ) -RRB- cord-019043-cqmqwl3i 243 31 Heart heart NN cord-019043-cqmqwl3i 243 32 rate rate NN cord-019043-cqmqwl3i 243 33 > > XX cord-019043-cqmqwl3i 243 34 90 90 CD cord-019043-cqmqwl3i 243 35 / / SYM cord-019043-cqmqwl3i 243 36 min min NN cord-019043-cqmqwl3i 243 37 or or CC cord-019043-cqmqwl3i 243 38 more more JJR cord-019043-cqmqwl3i 243 39 than than IN cord-019043-cqmqwl3i 243 40 2 2 CD cord-019043-cqmqwl3i 243 41 standard standard JJ cord-019043-cqmqwl3i 243 42 deviations deviation NNS cord-019043-cqmqwl3i 243 43 above above IN cord-019043-cqmqwl3i 243 44 normal normal JJ cord-019043-cqmqwl3i 243 45 for for IN cord-019043-cqmqwl3i 243 46 age age NN cord-019043-cqmqwl3i 243 47 Tachypnea Tachypnea NNP cord-019043-cqmqwl3i 243 48 Altered alter VBD cord-019043-cqmqwl3i 243 49 mental mental JJ cord-019043-cqmqwl3i 243 50 status status NN cord-019043-cqmqwl3i 244 1 Significant significant JJ cord-019043-cqmqwl3i 244 2 edema edema NN cord-019043-cqmqwl3i 244 3 or or CC cord-019043-cqmqwl3i 244 4 positive positive JJ cord-019043-cqmqwl3i 244 5 fluid fluid JJ cord-019043-cqmqwl3i 244 6 balance balance NN cord-019043-cqmqwl3i 244 7 ( ( -LRB- cord-019043-cqmqwl3i 244 8 > > XX cord-019043-cqmqwl3i 245 1 20 20 CD cord-019043-cqmqwl3i 245 2 mL ml NN cord-019043-cqmqwl3i 245 3 / / SYM cord-019043-cqmqwl3i 245 4 kg kg NN cord-019043-cqmqwl3i 245 5 over over IN cord-019043-cqmqwl3i 245 6 24 24 CD cord-019043-cqmqwl3i 245 7 h h NN cord-019043-cqmqwl3i 245 8 ) ) -RRB- cord-019043-cqmqwl3i 246 1 Hyperglycemia hyperglycemia NN cord-019043-cqmqwl3i 246 2 ( ( -LRB- cord-019043-cqmqwl3i 246 3 blood blood NN cord-019043-cqmqwl3i 246 4 glucose glucose NN cord-019043-cqmqwl3i 246 5 > > XX cord-019043-cqmqwl3i 246 6 7.7 7.7 CD cord-019043-cqmqwl3i 246 7 mmol mmol JJ cord-019043-cqmqwl3i 246 8 / / SYM cord-019043-cqmqwl3i 246 9 L L NNP cord-019043-cqmqwl3i 246 10 ) ) -RRB- cord-019043-cqmqwl3i 246 11 in in IN cord-019043-cqmqwl3i 246 12 the the DT cord-019043-cqmqwl3i 246 13 absence absence NN cord-019043-cqmqwl3i 246 14 of of IN cord-019043-cqmqwl3i 246 15 DM DM NNP cord-019043-cqmqwl3i 246 16 Leukocytosis Leukocytosis NNP cord-019043-cqmqwl3i 246 17 ( ( -LRB- cord-019043-cqmqwl3i 246 18 WBC WBC NNP cord-019043-cqmqwl3i 247 1 > > XX cord-019043-cqmqwl3i 248 1 12,000 12,000 CD cord-019043-cqmqwl3i 248 2 / / SYM cord-019043-cqmqwl3i 248 3 μL μL NNP cord-019043-cqmqwl3i 248 4 ) ) -RRB- cord-019043-cqmqwl3i 248 5 or or CC cord-019043-cqmqwl3i 248 6 leukopenia leukopenia NN cord-019043-cqmqwl3i 249 1 ( ( -LRB- cord-019043-cqmqwl3i 249 2 WBC WBC NNP cord-019043-cqmqwl3i 249 3 < < XX cord-019043-cqmqwl3i 249 4 4,000 4,000 CD cord-019043-cqmqwl3i 249 5 / / SYM cord-019043-cqmqwl3i 249 6 μL μl NN cord-019043-cqmqwl3i 249 7 ) ) -RRB- cord-019043-cqmqwl3i 250 1 or or CC cord-019043-cqmqwl3i 250 2 > > XX cord-019043-cqmqwl3i 250 3 10 10 CD cord-019043-cqmqwl3i 250 4 % % NN cord-019043-cqmqwl3i 250 5 immature immature JJ cord-019043-cqmqwl3i 250 6 forms form NNS cord-019043-cqmqwl3i 250 7 Plasma plasma NN cord-019043-cqmqwl3i 250 8 C c NN cord-019043-cqmqwl3i 250 9 - - HYPH cord-019043-cqmqwl3i 250 10 reactive reactive JJ cord-019043-cqmqwl3i 250 11 protein protein NN cord-019043-cqmqwl3i 251 1 more more JJR cord-019043-cqmqwl3i 251 2 than than IN cord-019043-cqmqwl3i 251 3 2 2 CD cord-019043-cqmqwl3i 251 4 standard standard JJ cord-019043-cqmqwl3i 251 5 deviations deviation NNS cord-019043-cqmqwl3i 251 6 above above IN cord-019043-cqmqwl3i 251 7 the the DT cord-019043-cqmqwl3i 251 8 normal normal JJ cord-019043-cqmqwl3i 251 9 value value NN cord-019043-cqmqwl3i 252 1 Plasma plasma NN cord-019043-cqmqwl3i 252 2 procalcitonin procalcitonin NNS cord-019043-cqmqwl3i 253 1 more more JJR cord-019043-cqmqwl3i 253 2 than than IN cord-019043-cqmqwl3i 253 3 2 2 CD cord-019043-cqmqwl3i 253 4 standard standard JJ cord-019043-cqmqwl3i 253 5 deviations deviation NNS cord-019043-cqmqwl3i 253 6 above above IN cord-019043-cqmqwl3i 253 7 the the DT cord-019043-cqmqwl3i 253 8 normal normal JJ cord-019043-cqmqwl3i 253 9 value value NN cord-019043-cqmqwl3i 253 10 AKI AKI NNP cord-019043-cqmqwl3i 253 11 is be VBZ cord-019043-cqmqwl3i 253 12 a a DT cord-019043-cqmqwl3i 253 13 syndrome syndrome NN cord-019043-cqmqwl3i 253 14 with with IN cord-019043-cqmqwl3i 253 15 a a DT cord-019043-cqmqwl3i 253 16 spectrum spectrum NN cord-019043-cqmqwl3i 253 17 of of IN cord-019043-cqmqwl3i 253 18 contributing contribute VBG cord-019043-cqmqwl3i 253 19 factors factor NNS cord-019043-cqmqwl3i 253 20 . . . cord-019043-cqmqwl3i 254 1 The the DT cord-019043-cqmqwl3i 254 2 risk risk NN cord-019043-cqmqwl3i 254 3 factors factor NNS cord-019043-cqmqwl3i 254 4 for for IN cord-019043-cqmqwl3i 254 5 development development NN cord-019043-cqmqwl3i 254 6 of of IN cord-019043-cqmqwl3i 254 7 AKI AKI NNP cord-019043-cqmqwl3i 254 8 are be VBP cord-019043-cqmqwl3i 254 9 often often RB cord-019043-cqmqwl3i 254 10 multidimensional multidimensional JJ cord-019043-cqmqwl3i 254 11 and and CC cord-019043-cqmqwl3i 254 12 are be VBP cord-019043-cqmqwl3i 254 13 related relate VBN cord-019043-cqmqwl3i 254 14 to to IN cord-019043-cqmqwl3i 254 15 synergy synergy NN cord-019043-cqmqwl3i 254 16 between between IN cord-019043-cqmqwl3i 254 17 premorbid premorbid NN cord-019043-cqmqwl3i 254 18 susceptibility susceptibility NN cord-019043-cqmqwl3i 254 19 ( ( -LRB- cord-019043-cqmqwl3i 254 20 i.e. i.e. FW cord-019043-cqmqwl3i 254 21 , , , cord-019043-cqmqwl3i 254 22 older old JJR cord-019043-cqmqwl3i 254 23 age age NN cord-019043-cqmqwl3i 254 24 , , , cord-019043-cqmqwl3i 254 25 CKD CKD NNP cord-019043-cqmqwl3i 254 26 , , , cord-019043-cqmqwl3i 254 27 diabetes diabete VBZ cord-019043-cqmqwl3i 254 28 mellitus mellitus NN cord-019043-cqmqwl3i 254 29 , , , cord-019043-cqmqwl3i 254 30 hypertension hypertension NN cord-019043-cqmqwl3i 254 31 , , , cord-019043-cqmqwl3i 254 32 liver liver NN cord-019043-cqmqwl3i 254 33 disease disease NN cord-019043-cqmqwl3i 254 34 ) ) -RRB- cord-019043-cqmqwl3i 254 35 and and CC cord-019043-cqmqwl3i 254 36 factors factor NNS cord-019043-cqmqwl3i 254 37 contributing contribute VBG cord-019043-cqmqwl3i 254 38 to to IN cord-019043-cqmqwl3i 254 39 critical critical JJ cord-019043-cqmqwl3i 254 40 illness illness NN cord-019043-cqmqwl3i 254 41 ( ( -LRB- cord-019043-cqmqwl3i 254 42 i.e. i.e. FW cord-019043-cqmqwl3i 254 43 , , , cord-019043-cqmqwl3i 254 44 sepsis sepsis NN cord-019043-cqmqwl3i 254 45 , , , cord-019043-cqmqwl3i 254 46 shock shock NN cord-019043-cqmqwl3i 254 47 states state NNS cord-019043-cqmqwl3i 254 48 , , , cord-019043-cqmqwl3i 254 49 diagnostic diagnostic JJ cord-019043-cqmqwl3i 254 50 procedures procedure NNS cord-019043-cqmqwl3i 254 51 involving involve VBG cord-019043-cqmqwl3i 254 52 contrast contrast NN cord-019043-cqmqwl3i 254 53 media medium NNS cord-019043-cqmqwl3i 254 54 , , , cord-019043-cqmqwl3i 254 55 major major JJ cord-019043-cqmqwl3i 254 56 surgery surgery NN cord-019043-cqmqwl3i 254 57 ) ) -RRB- cord-019043-cqmqwl3i 254 58 [ [ -LRB- cord-019043-cqmqwl3i 254 59 13 13 CD cord-019043-cqmqwl3i 254 60 , , , cord-019043-cqmqwl3i 254 61 14 14 CD cord-019043-cqmqwl3i 254 62 ] ] -RRB- cord-019043-cqmqwl3i 254 63 . . . cord-019043-cqmqwl3i 255 1 The the DT cord-019043-cqmqwl3i 255 2 diagnostic diagnostic JJ cord-019043-cqmqwl3i 255 3 evaluation evaluation NN cord-019043-cqmqwl3i 255 4 of of IN cord-019043-cqmqwl3i 255 5 AKI AKI NNP cord-019043-cqmqwl3i 255 6 should should MD cord-019043-cqmqwl3i 255 7 Box Box NNP cord-019043-cqmqwl3i 255 8 32 32 CD cord-019043-cqmqwl3i 255 9 . . . cord-019043-cqmqwl3i 255 10 6 6 CD cord-019043-cqmqwl3i 255 11 _SP cord-019043-cqmqwl3i 256 1 To to TO cord-019043-cqmqwl3i 256 2 be be VB cord-019043-cqmqwl3i 256 3 completed complete VBN cord-019043-cqmqwl3i 256 4 within within IN cord-019043-cqmqwl3i 256 5 3 3 CD cord-019043-cqmqwl3i 256 6 h h NN cord-019043-cqmqwl3i 257 1 • • NNP cord-019043-cqmqwl3i 258 1 Measure measure NN cord-019043-cqmqwl3i 258 2 serum serum NN cord-019043-cqmqwl3i 258 3 lactate lactate NN cord-019043-cqmqwl3i 258 4 . . . cord-019043-cqmqwl3i 259 1 • • NNP cord-019043-cqmqwl3i 260 1 Obtain obtain VB cord-019043-cqmqwl3i 260 2 blood blood NN cord-019043-cqmqwl3i 260 3 cultures culture NNS cord-019043-cqmqwl3i 260 4 prior prior RB cord-019043-cqmqwl3i 260 5 to to IN cord-019043-cqmqwl3i 260 6 administration administration NN cord-019043-cqmqwl3i 260 7 of of IN cord-019043-cqmqwl3i 260 8 antimicrobials antimicrobial NNS cord-019043-cqmqwl3i 260 9 . . . cord-019043-cqmqwl3i 261 1 • • NNP cord-019043-cqmqwl3i 262 1 Administer administer VB cord-019043-cqmqwl3i 262 2 broad broad JJ cord-019043-cqmqwl3i 262 3 - - HYPH cord-019043-cqmqwl3i 262 4 spectrum spectrum NN cord-019043-cqmqwl3i 262 5 antimicrobials antimicrobial NNS cord-019043-cqmqwl3i 262 6 . . . cord-019043-cqmqwl3i 263 1 • • NNP cord-019043-cqmqwl3i 264 1 Administer administer VB cord-019043-cqmqwl3i 264 2 30 30 CD cord-019043-cqmqwl3i 264 3 mL ml NN cord-019043-cqmqwl3i 264 4 / / SYM cord-019043-cqmqwl3i 264 5 kg kg NN cord-019043-cqmqwl3i 264 6 crystalloid crystalloid NN cord-019043-cqmqwl3i 264 7 for for IN cord-019043-cqmqwl3i 264 8 hypotension hypotension NN cord-019043-cqmqwl3i 264 9 or or CC cord-019043-cqmqwl3i 264 10 lactate lactate NN cord-019043-cqmqwl3i 264 11 ≥4 ≥4 JJ cord-019043-cqmqwl3i 264 12 mmol mmol NNP cord-019043-cqmqwl3i 264 13 / / SYM cord-019043-cqmqwl3i 264 14 L. L. NNP cord-019043-cqmqwl3i 265 1 To to TO cord-019043-cqmqwl3i 265 2 be be VB cord-019043-cqmqwl3i 265 3 completed complete VBN cord-019043-cqmqwl3i 265 4 within within IN cord-019043-cqmqwl3i 265 5 6 6 CD cord-019043-cqmqwl3i 265 6 h h NN cord-019043-cqmqwl3i 266 1 • • NNP cord-019043-cqmqwl3i 267 1 Administer administer VB cord-019043-cqmqwl3i 267 2 vasopressors vasopressor NNS cord-019043-cqmqwl3i 267 3 ( ( -LRB- cord-019043-cqmqwl3i 267 4 for for IN cord-019043-cqmqwl3i 267 5 hypotension hypotension NN cord-019043-cqmqwl3i 267 6 not not RB cord-019043-cqmqwl3i 267 7 responsive responsive JJ cord-019043-cqmqwl3i 267 8 to to IN cord-019043-cqmqwl3i 267 9 initial initial JJ cord-019043-cqmqwl3i 267 10 fluid fluid JJ cord-019043-cqmqwl3i 267 11 resuscitation resuscitation NN cord-019043-cqmqwl3i 267 12 ) ) -RRB- cord-019043-cqmqwl3i 267 13 to to TO cord-019043-cqmqwl3i 267 14 maintain maintain VB cord-019043-cqmqwl3i 267 15 a a DT cord-019043-cqmqwl3i 267 16 mean mean JJ cord-019043-cqmqwl3i 267 17 arterial arterial JJ cord-019043-cqmqwl3i 267 18 pressure pressure NN cord-019043-cqmqwl3i 267 19 ( ( -LRB- cord-019043-cqmqwl3i 267 20 MAP MAP NNP cord-019043-cqmqwl3i 267 21 ) ) -RRB- cord-019043-cqmqwl3i 267 22 ≥65 ≥65 NN cord-019043-cqmqwl3i 267 23 mmHg mmHg NNP cord-019043-cqmqwl3i 267 24 . . . cord-019043-cqmqwl3i 267 25 central central JJ cord-019043-cqmqwl3i 267 26 venous venous JJ cord-019043-cqmqwl3i 267 27 oxygenation oxygenation NN cord-019043-cqmqwl3i 267 28 ( ( -LRB- cord-019043-cqmqwl3i 267 29 ScVO ScVO NNP cord-019043-cqmqwl3i 267 30 2 2 CD cord-019043-cqmqwl3i 267 31 ) ) -RRB- cord-019043-cqmqwl3i 267 32 and and CC cord-019043-cqmqwl3i 267 33 resuscitate resuscitate VB cord-019043-cqmqwl3i 267 34 to to TO cord-019043-cqmqwl3i 267 35 target target VB cord-019043-cqmqwl3i 267 36 CVP CVP NNP cord-019043-cqmqwl3i 267 37 ≥8 ≥8 NNP cord-019043-cqmqwl3i 267 38 cmH cmh NN cord-019043-cqmqwl3i 267 39 2 2 CD cord-019043-cqmqwl3i 267 40 O o NN cord-019043-cqmqwl3i 267 41 and and CC cord-019043-cqmqwl3i 267 42 ScVO ScVO NNP cord-019043-cqmqwl3i 267 43 2 2 CD cord-019043-cqmqwl3i 267 44 ≥70 ≥70 NNP cord-019043-cqmqwl3i 267 45 % % NN cord-019043-cqmqwl3i 267 46 . . . cord-019043-cqmqwl3i 268 1 • • NNP cord-019043-cqmqwl3i 269 1 Remeasure remeasure VB cord-019043-cqmqwl3i 269 2 serum serum NN cord-019043-cqmqwl3i 269 3 lactate lactate NN cord-019043-cqmqwl3i 269 4 if if IN cord-019043-cqmqwl3i 269 5 initial initial JJ cord-019043-cqmqwl3i 269 6 value value NN cord-019043-cqmqwl3i 269 7 was be VBD cord-019043-cqmqwl3i 269 8 elevated elevate VBN cord-019043-cqmqwl3i 269 9 and and CC cord-019043-cqmqwl3i 269 10 resuscitate resuscitate VB cord-019043-cqmqwl3i 269 11 to to TO cord-019043-cqmqwl3i 269 12 target target VB cord-019043-cqmqwl3i 269 13 normalization normalization NN cord-019043-cqmqwl3i 269 14 . . . cord-019043-cqmqwl3i 270 1 Antimicrobial antimicrobial JJ cord-019043-cqmqwl3i 270 2 therapy therapy NN cord-019043-cqmqwl3i 270 3 and and CC cord-019043-cqmqwl3i 270 4 source source NN cord-019043-cqmqwl3i 270 5 control control NN cord-019043-cqmqwl3i 271 1 • • NNP cord-019043-cqmqwl3i 271 2 Aim aim VB cord-019043-cqmqwl3i 271 3 to to TO cord-019043-cqmqwl3i 271 4 administer administer VB cord-019043-cqmqwl3i 271 5 broad broad JJ cord-019043-cqmqwl3i 271 6 - - HYPH cord-019043-cqmqwl3i 271 7 spectrum spectrum NN cord-019043-cqmqwl3i 271 8 " " `` cord-019043-cqmqwl3i 271 9 effective effective JJ cord-019043-cqmqwl3i 271 10 " " '' cord-019043-cqmqwl3i 271 11 intravenous intravenous JJ cord-019043-cqmqwl3i 271 12 antimicrobial antimicrobial JJ cord-019043-cqmqwl3i 271 13 therapy therapy NN cord-019043-cqmqwl3i 271 14 within within IN cord-019043-cqmqwl3i 271 15 the the DT cord-019043-cqmqwl3i 271 16 first first JJ cord-019043-cqmqwl3i 271 17 1 1 CD cord-019043-cqmqwl3i 271 18 h h NN cord-019043-cqmqwl3i 271 19 of of IN cord-019043-cqmqwl3i 271 20 recognition recognition NN cord-019043-cqmqwl3i 271 21 of of IN cord-019043-cqmqwl3i 271 22 sepsis sepsis NN cord-019043-cqmqwl3i 271 23 . . . cord-019043-cqmqwl3i 272 1 Each each DT cord-019043-cqmqwl3i 272 2 1 1 CD cord-019043-cqmqwl3i 272 3 h h NN cord-019043-cqmqwl3i 272 4 delay delay NN cord-019043-cqmqwl3i 272 5 in in IN cord-019043-cqmqwl3i 272 6 administration administration NN cord-019043-cqmqwl3i 272 7 of of IN cord-019043-cqmqwl3i 272 8 appropriate appropriate JJ cord-019043-cqmqwl3i 272 9 antimicrobials antimicrobial NNS cord-019043-cqmqwl3i 272 10 during during IN cord-019043-cqmqwl3i 272 11 the the DT cord-019043-cqmqwl3i 272 12 first first JJ cord-019043-cqmqwl3i 272 13 6 6 CD cord-019043-cqmqwl3i 272 14 h h NN cord-019043-cqmqwl3i 272 15 is be VBZ cord-019043-cqmqwl3i 272 16 associated associate VBN cord-019043-cqmqwl3i 272 17 with with IN cord-019043-cqmqwl3i 272 18 an an DT cord-019043-cqmqwl3i 272 19 8 8 CD cord-019043-cqmqwl3i 272 20 % % NN cord-019043-cqmqwl3i 272 21 decrease decrease NN cord-019043-cqmqwl3i 272 22 in in IN cord-019043-cqmqwl3i 272 23 survival survival NN cord-019043-cqmqwl3i 272 24 . . . cord-019043-cqmqwl3i 273 1 • • NNP cord-019043-cqmqwl3i 274 1 Initial initial JJ cord-019043-cqmqwl3i 274 2 short short JJ cord-019043-cqmqwl3i 274 3 - - HYPH cord-019043-cqmqwl3i 274 4 term term NN cord-019043-cqmqwl3i 274 5 ( ( -LRB- cord-019043-cqmqwl3i 274 6 3 3 CD cord-019043-cqmqwl3i 274 7 - - SYM cord-019043-cqmqwl3i 274 8 5 5 CD cord-019043-cqmqwl3i 274 9 days day NNS cord-019043-cqmqwl3i 274 10 ) ) -RRB- cord-019043-cqmqwl3i 274 11 administration administration NN cord-019043-cqmqwl3i 274 12 of of IN cord-019043-cqmqwl3i 274 13 empiric empiric JJ cord-019043-cqmqwl3i 274 14 combination combination NN cord-019043-cqmqwl3i 274 15 antimicrobial antimicrobial JJ cord-019043-cqmqwl3i 274 16 therapy therapy NN cord-019043-cqmqwl3i 274 17 should should MD cord-019043-cqmqwl3i 274 18 be be VB cord-019043-cqmqwl3i 274 19 undertaken undertake VBN cord-019043-cqmqwl3i 274 20 for for IN cord-019043-cqmqwl3i 274 21 severe severe JJ cord-019043-cqmqwl3i 274 22 sepsis/ sepsis/ HYPH cord-019043-cqmqwl3i 274 23 septic septic JJ cord-019043-cqmqwl3i 274 24 shock shock NN cord-019043-cqmqwl3i 274 25 or or CC cord-019043-cqmqwl3i 274 26 difficult difficult JJ cord-019043-cqmqwl3i 274 27 - - HYPH cord-019043-cqmqwl3i 274 28 to to TO cord-019043-cqmqwl3i 274 29 - - HYPH cord-019043-cqmqwl3i 274 30 treat treat VB cord-019043-cqmqwl3i 274 31 sources source NNS cord-019043-cqmqwl3i 274 32 of of IN cord-019043-cqmqwl3i 274 33 infection infection NN cord-019043-cqmqwl3i 274 34 or or CC cord-019043-cqmqwl3i 274 35 suspicion suspicion NN cord-019043-cqmqwl3i 274 36 of of IN cord-019043-cqmqwl3i 274 37 multidrug multidrug NN cord-019043-cqmqwl3i 274 38 - - HYPH cord-019043-cqmqwl3i 274 39 resistant resistant JJ cord-019043-cqmqwl3i 274 40 organisms organism NNS cord-019043-cqmqwl3i 274 41 . . . cord-019043-cqmqwl3i 275 1 • • NNP cord-019043-cqmqwl3i 276 1 Evaluation evaluation NN cord-019043-cqmqwl3i 276 2 for for IN cord-019043-cqmqwl3i 276 3 a a DT cord-019043-cqmqwl3i 276 4 specific specific JJ cord-019043-cqmqwl3i 276 5 anatomical anatomical JJ cord-019043-cqmqwl3i 276 6 diagnosis diagnosis NN cord-019043-cqmqwl3i 276 7 of of IN cord-019043-cqmqwl3i 276 8 infection infection NN cord-019043-cqmqwl3i 276 9 should should MD cord-019043-cqmqwl3i 276 10 be be VB cord-019043-cqmqwl3i 276 11 undertaken undertake VBN cord-019043-cqmqwl3i 276 12 for for IN cord-019043-cqmqwl3i 276 13 consideration consideration NN cord-019043-cqmqwl3i 276 14 for for IN cord-019043-cqmqwl3i 276 15 emergent emergent JJ cord-019043-cqmqwl3i 276 16 ( ( -LRB- cord-019043-cqmqwl3i 276 17 within within IN cord-019043-cqmqwl3i 276 18 6 6 CD cord-019043-cqmqwl3i 276 19 - - SYM cord-019043-cqmqwl3i 276 20 12 12 CD cord-019043-cqmqwl3i 276 21 h h NN cord-019043-cqmqwl3i 276 22 ) ) -RRB- cord-019043-cqmqwl3i 276 23 source source NN cord-019043-cqmqwl3i 276 24 control control NN cord-019043-cqmqwl3i 276 25 measures measure NNS cord-019043-cqmqwl3i 276 26 ( ( -LRB- cord-019043-cqmqwl3i 276 27 i.e. i.e. FW cord-019043-cqmqwl3i 276 28 , , , cord-019043-cqmqwl3i 276 29 surgical surgical JJ cord-019043-cqmqwl3i 276 30 for for IN cord-019043-cqmqwl3i 276 31 septic septic JJ cord-019043-cqmqwl3i 276 32 arthritis arthritis NN cord-019043-cqmqwl3i 276 33 , , , cord-019043-cqmqwl3i 276 34 catheter catheter NN cord-019043-cqmqwl3i 276 35 removal removal NN cord-019043-cqmqwl3i 276 36 for for IN cord-019043-cqmqwl3i 276 37 bloodstream bloodstream NN cord-019043-cqmqwl3i 276 38 infection infection NN cord-019043-cqmqwl3i 276 39 , , , cord-019043-cqmqwl3i 276 40 chest chest NN cord-019043-cqmqwl3i 276 41 thoracostomy thoracostomy NN cord-019043-cqmqwl3i 276 42 tube tube NN cord-019043-cqmqwl3i 276 43 insertion insertion NN cord-019043-cqmqwl3i 276 44 for for IN cord-019043-cqmqwl3i 276 45 empyema empyema NNP cord-019043-cqmqwl3i 276 46 ) ) -RRB- cord-019043-cqmqwl3i 276 47 . . . cord-019043-cqmqwl3i 277 1 Delay delay NN cord-019043-cqmqwl3i 277 2 to to IN cord-019043-cqmqwl3i 277 3 source source NN cord-019043-cqmqwl3i 277 4 control control NN cord-019043-cqmqwl3i 277 5 when when WRB cord-019043-cqmqwl3i 277 6 present present JJ cord-019043-cqmqwl3i 277 7 is be VBZ cord-019043-cqmqwl3i 277 8 also also RB cord-019043-cqmqwl3i 277 9 associated associate VBN cord-019043-cqmqwl3i 277 10 with with IN cord-019043-cqmqwl3i 277 11 significant significant JJ cord-019043-cqmqwl3i 277 12 decrease decrease NN cord-019043-cqmqwl3i 277 13 in in IN cord-019043-cqmqwl3i 277 14 survival survival NN cord-019043-cqmqwl3i 277 15 . . . cord-019043-cqmqwl3i 278 1 Source source NN cord-019043-cqmqwl3i 278 2 : : : cord-019043-cqmqwl3i 279 1 Reproduced reproduce VBN cord-019043-cqmqwl3i 279 2 with with IN cord-019043-cqmqwl3i 279 3 kind kind JJ cord-019043-cqmqwl3i 279 4 permission permission NN cord-019043-cqmqwl3i 279 5 from from IN cord-019043-cqmqwl3i 279 6 Springer Springer NNP cord-019043-cqmqwl3i 279 7 Science Science NNP cord-019043-cqmqwl3i 279 8 and and CC cord-019043-cqmqwl3i 279 9 Business Business NNP cord-019043-cqmqwl3i 279 10 Media Media NNP cord-019043-cqmqwl3i 279 11 : : : cord-019043-cqmqwl3i 280 1 Dellinger Dellinger NNP cord-019043-cqmqwl3i 280 2 et et IN cord-019043-cqmqwl3i 280 3 al al NNP cord-019043-cqmqwl3i 280 4 . . . cord-019043-cqmqwl3i 281 1 [ [ -LRB- cord-019043-cqmqwl3i 281 2 9 9 CD cord-019043-cqmqwl3i 281 3 ] ] -RRB- cord-019043-cqmqwl3i 281 4 Box Box NNP cord-019043-cqmqwl3i 281 5 32.7 32.7 CD cord-019043-cqmqwl3i 281 6 . . . cord-019043-cqmqwl3i 282 1 Relevant Relevant NNP cord-019043-cqmqwl3i 282 2 Clinical Clinical NNP cord-019043-cqmqwl3i 282 3 Practice Practice NNP cord-019043-cqmqwl3i 282 4 Guidelines Guidelines NNPS cord-019043-cqmqwl3i 282 5 integrate integrate VBP cord-019043-cqmqwl3i 282 6 routine routine JJ cord-019043-cqmqwl3i 282 7 biochemistry biochemistry NN cord-019043-cqmqwl3i 282 8 , , , cord-019043-cqmqwl3i 282 9 urinalysis urinalysis NN cord-019043-cqmqwl3i 282 10 and and CC cord-019043-cqmqwl3i 282 11 imaging imaging NN cord-019043-cqmqwl3i 282 12 where where WRB cord-019043-cqmqwl3i 282 13 indicated indicate VBN cord-019043-cqmqwl3i 282 14 to to TO cord-019043-cqmqwl3i 282 15 rule rule VB cord-019043-cqmqwl3i 282 16 out out RP cord-019043-cqmqwl3i 282 17 immediately immediately RB cord-019043-cqmqwl3i 282 18 reversible reversible JJ cord-019043-cqmqwl3i 282 19 etiologies etiology NNS cord-019043-cqmqwl3i 282 20 ( ( -LRB- cord-019043-cqmqwl3i 282 21 i.e. i.e. FW cord-019043-cqmqwl3i 282 22 , , , cord-019043-cqmqwl3i 282 23 post post JJ cord-019043-cqmqwl3i 282 24 - - JJ cord-019043-cqmqwl3i 282 25 obstructive obstructive JJ cord-019043-cqmqwl3i 282 26 ) ) -RRB- cord-019043-cqmqwl3i 282 27 or or CC cord-019043-cqmqwl3i 282 28 those those DT cord-019043-cqmqwl3i 282 29 requiring require VBG cord-019043-cqmqwl3i 282 30 specialized specialized JJ cord-019043-cqmqwl3i 282 31 interventions intervention NNS cord-019043-cqmqwl3i 282 32 ( ( -LRB- cord-019043-cqmqwl3i 282 33 i.e. i.e. FW cord-019043-cqmqwl3i 282 34 , , , cord-019043-cqmqwl3i 282 35 vasculitis vasculitis NN cord-019043-cqmqwl3i 282 36 ) ) -RRB- cord-019043-cqmqwl3i 282 37 . . . cord-019043-cqmqwl3i 283 1 An an DT cord-019043-cqmqwl3i 283 2 understanding understanding NN cord-019043-cqmqwl3i 283 3 of of IN cord-019043-cqmqwl3i 283 4 the the DT cord-019043-cqmqwl3i 283 5 pathophysiology pathophysiology NN cord-019043-cqmqwl3i 283 6 of of IN cord-019043-cqmqwl3i 283 7 AKI AKI NNP cord-019043-cqmqwl3i 283 8 is be VBZ cord-019043-cqmqwl3i 283 9 important important JJ cord-019043-cqmqwl3i 283 10 to to TO cord-019043-cqmqwl3i 283 11 provide provide VB cord-019043-cqmqwl3i 283 12 appropriate appropriate JJ cord-019043-cqmqwl3i 283 13 management management NN cord-019043-cqmqwl3i 283 14 for for IN cord-019043-cqmqwl3i 283 15 these these DT cord-019043-cqmqwl3i 283 16 patients patient NNS cord-019043-cqmqwl3i 283 17 . . . cord-019043-cqmqwl3i 284 1 Our -PRON- PRP$ cord-019043-cqmqwl3i 284 2 current current JJ cord-019043-cqmqwl3i 284 3 understanding understanding NN cord-019043-cqmqwl3i 284 4 of of IN cord-019043-cqmqwl3i 284 5 the the DT cord-019043-cqmqwl3i 284 6 pathophysiologic pathophysiologic NN cord-019043-cqmqwl3i 284 7 mechanisms mechanism NNS cord-019043-cqmqwl3i 284 8 contributing contribute VBG cord-019043-cqmqwl3i 284 9 to to IN cord-019043-cqmqwl3i 284 10 AKI AKI NNP cord-019043-cqmqwl3i 284 11 remains remain VBZ cord-019043-cqmqwl3i 284 12 incomplete incomplete JJ cord-019043-cqmqwl3i 284 13 ; ; : cord-019043-cqmqwl3i 284 14 however however RB cord-019043-cqmqwl3i 284 15 , , , cord-019043-cqmqwl3i 284 16 contrary contrary JJ cord-019043-cqmqwl3i 284 17 to to IN cord-019043-cqmqwl3i 284 18 the the DT cord-019043-cqmqwl3i 284 19 conventional conventional JJ cord-019043-cqmqwl3i 284 20 view view NN cord-019043-cqmqwl3i 284 21 , , , cord-019043-cqmqwl3i 284 22 recent recent JJ cord-019043-cqmqwl3i 284 23 data datum NNS cord-019043-cqmqwl3i 284 24 argue argue VBP cord-019043-cqmqwl3i 284 25 against against IN cord-019043-cqmqwl3i 284 26 ischemia ischemia NN cord-019043-cqmqwl3i 284 27 - - HYPH cord-019043-cqmqwl3i 284 28 reperfusion reperfusion NN cord-019043-cqmqwl3i 284 29 as as IN cord-019043-cqmqwl3i 284 30 the the DT cord-019043-cqmqwl3i 284 31 predominant predominant JJ cord-019043-cqmqwl3i 284 32 pathophysiologic pathophysiologic NN cord-019043-cqmqwl3i 284 33 mechanism mechanism NN cord-019043-cqmqwl3i 284 34 contributing contribute VBG cord-019043-cqmqwl3i 284 35 to to IN cord-019043-cqmqwl3i 284 36 AKI AKI NNP cord-019043-cqmqwl3i 284 37 . . . cord-019043-cqmqwl3i 285 1 The the DT cord-019043-cqmqwl3i 285 2 causal causal JJ cord-019043-cqmqwl3i 285 3 role role NN cord-019043-cqmqwl3i 285 4 of of IN cord-019043-cqmqwl3i 285 5 alternations alternation NNS cord-019043-cqmqwl3i 285 6 in in IN cord-019043-cqmqwl3i 285 7 renal renal JJ cord-019043-cqmqwl3i 285 8 blood blood NN cord-019043-cqmqwl3i 285 9 flow flow NN cord-019043-cqmqwl3i 285 10 , , , cord-019043-cqmqwl3i 285 11 microcirculation microcirculation NN cord-019043-cqmqwl3i 285 12 , , , cord-019043-cqmqwl3i 285 13 and and CC cord-019043-cqmqwl3i 285 14 endothelial endothelial JJ cord-019043-cqmqwl3i 285 15 function function NN cord-019043-cqmqwl3i 285 16 , , , cord-019043-cqmqwl3i 285 17 immune immune JJ cord-019043-cqmqwl3i 285 18 cell cell NN cord-019043-cqmqwl3i 285 19 infiltration infiltration NN cord-019043-cqmqwl3i 285 20 and and CC cord-019043-cqmqwl3i 285 21 activation activation NN cord-019043-cqmqwl3i 285 22 , , , cord-019043-cqmqwl3i 285 23 immunemediated immunemediated JJ cord-019043-cqmqwl3i 285 24 toxic toxic JJ cord-019043-cqmqwl3i 285 25 injury injury NN cord-019043-cqmqwl3i 285 26 and and CC cord-019043-cqmqwl3i 285 27 apoptosis apoptosis NN cord-019043-cqmqwl3i 285 28 , , , cord-019043-cqmqwl3i 285 29 and and CC cord-019043-cqmqwl3i 285 30 inflammatory inflammatory JJ cord-019043-cqmqwl3i 285 31 mediator mediator NN cord-019043-cqmqwl3i 285 32 - - HYPH cord-019043-cqmqwl3i 285 33 induced induce VBN cord-019043-cqmqwl3i 285 34 organ organ NN cord-019043-cqmqwl3i 285 35 cross cross NN cord-019043-cqmqwl3i 285 36 talk talk NN cord-019043-cqmqwl3i 285 37 is be VBZ cord-019043-cqmqwl3i 285 38 only only RB cord-019043-cqmqwl3i 285 39 beginning begin VBG cord-019043-cqmqwl3i 285 40 to to TO cord-019043-cqmqwl3i 285 41 be be VB cord-019043-cqmqwl3i 285 42 better well RBR cord-019043-cqmqwl3i 285 43 understood understand VBN cord-019043-cqmqwl3i 285 44 . . . cord-019043-cqmqwl3i 286 1 The the DT cord-019043-cqmqwl3i 286 2 general general JJ cord-019043-cqmqwl3i 286 3 strategies strategy NNS cord-019043-cqmqwl3i 286 4 for for IN cord-019043-cqmqwl3i 286 5 prevention prevention NN cord-019043-cqmqwl3i 286 6 and and CC cord-019043-cqmqwl3i 286 7 management management NN cord-019043-cqmqwl3i 286 8 of of IN cord-019043-cqmqwl3i 286 9 AKI AKI NNP cord-019043-cqmqwl3i 286 10 are be VBP cord-019043-cqmqwl3i 286 11 similar similar JJ cord-019043-cqmqwl3i 286 12 for for IN cord-019043-cqmqwl3i 286 13 those those DT cord-019043-cqmqwl3i 286 14 with with IN cord-019043-cqmqwl3i 286 15 and and CC cord-019043-cqmqwl3i 286 16 without without IN cord-019043-cqmqwl3i 286 17 CKD CKD NNP cord-019043-cqmqwl3i 286 18 [ [ -LRB- cord-019043-cqmqwl3i 286 19 16 16 CD cord-019043-cqmqwl3i 286 20 ] ] -RRB- cord-019043-cqmqwl3i 287 1 ( ( -LRB- cord-019043-cqmqwl3i 287 2 Table table NN cord-019043-cqmqwl3i 287 3 32 32 CD cord-019043-cqmqwl3i 287 4 .6 .6 CD cord-019043-cqmqwl3i 287 5 ) ) -RRB- cord-019043-cqmqwl3i 287 6 . . . cord-019043-cqmqwl3i 288 1 Specific specific JJ cord-019043-cqmqwl3i 288 2 interventions intervention NNS cord-019043-cqmqwl3i 288 3 for for IN cord-019043-cqmqwl3i 288 4 prevention prevention NN cord-019043-cqmqwl3i 288 5 and and CC cord-019043-cqmqwl3i 288 6 treatment treatment NN cord-019043-cqmqwl3i 288 7 of of IN cord-019043-cqmqwl3i 288 8 established establish VBN cord-019043-cqmqwl3i 288 9 AKI AKI NNP cord-019043-cqmqwl3i 288 10 are be VBP cord-019043-cqmqwl3i 288 11 few few JJ cord-019043-cqmqwl3i 288 12 and and CC cord-019043-cqmqwl3i 288 13 most most JJS cord-019043-cqmqwl3i 288 14 have have VBP cord-019043-cqmqwl3i 288 15 focused focus VBN cord-019043-cqmqwl3i 288 16 on on IN cord-019043-cqmqwl3i 288 17 preventing prevent VBG cord-019043-cqmqwl3i 288 18 development development NN cord-019043-cqmqwl3i 288 19 of of IN cord-019043-cqmqwl3i 288 20 contrast contrast NN cord-019043-cqmqwl3i 288 21 - - HYPH cord-019043-cqmqwl3i 288 22 induced induce VBN cord-019043-cqmqwl3i 288 23 AKI AKI NNP cord-019043-cqmqwl3i 288 24 in in IN cord-019043-cqmqwl3i 288 25 susceptible susceptible JJ cord-019043-cqmqwl3i 288 26 patients patient NNS cord-019043-cqmqwl3i 288 27 such such JJ cord-019043-cqmqwl3i 288 28 as as IN cord-019043-cqmqwl3i 288 29 those those DT cord-019043-cqmqwl3i 288 30 with with IN cord-019043-cqmqwl3i 288 31 CKD CKD NNP cord-019043-cqmqwl3i 288 32 . . . cord-019043-cqmqwl3i 289 1 Several several JJ cord-019043-cqmqwl3i 289 2 specific specific JJ cord-019043-cqmqwl3i 289 3 examples example NNS cord-019043-cqmqwl3i 289 4 of of IN cord-019043-cqmqwl3i 289 5 mitigating mitigate VBG cord-019043-cqmqwl3i 289 6 risk risk NN cord-019043-cqmqwl3i 289 7 of of IN cord-019043-cqmqwl3i 289 8 developing develop VBG cord-019043-cqmqwl3i 289 9 AKI AKI NNP cord-019043-cqmqwl3i 289 10 or or CC cord-019043-cqmqwl3i 289 11 its -PRON- PRP$ cord-019043-cqmqwl3i 289 12 complications complication NNS cord-019043-cqmqwl3i 289 13 are be VBP cord-019043-cqmqwl3i 289 14 outlined outline VBN cord-019043-cqmqwl3i 289 15 in in IN cord-019043-cqmqwl3i 289 16 Table Table NNP cord-019043-cqmqwl3i 289 17 32 32 CD cord-019043-cqmqwl3i 289 18 .7 .7 . cord-019043-cqmqwl3i 290 1 [ [ -LRB- cord-019043-cqmqwl3i 290 2 11 11 CD cord-019043-cqmqwl3i 290 3 , , , cord-019043-cqmqwl3i 290 4 16 16 CD cord-019043-cqmqwl3i 290 5 ] ] -RRB- cord-019043-cqmqwl3i 290 6 . . . cord-019043-cqmqwl3i 291 1 Renal renal JJ cord-019043-cqmqwl3i 291 2 replacement replacement NN cord-019043-cqmqwl3i 291 3 therapy therapy NN cord-019043-cqmqwl3i 291 4 ( ( -LRB- cord-019043-cqmqwl3i 291 5 RRT RRT NNP cord-019043-cqmqwl3i 291 6 ) ) -RRB- cord-019043-cqmqwl3i 291 7 is be VBZ cord-019043-cqmqwl3i 291 8 a a DT cord-019043-cqmqwl3i 291 9 vital vital JJ cord-019043-cqmqwl3i 291 10 , , , cord-019043-cqmqwl3i 291 11 life life NN cord-019043-cqmqwl3i 291 12 - - HYPH cord-019043-cqmqwl3i 291 13 sustaining sustain VBG cord-019043-cqmqwl3i 291 14 , , , cord-019043-cqmqwl3i 291 15 and and CC cord-019043-cqmqwl3i 291 16 organ organ NN cord-019043-cqmqwl3i 291 17 support support NN cord-019043-cqmqwl3i 291 18 technology technology NN cord-019043-cqmqwl3i 291 19 applied apply VBN cord-019043-cqmqwl3i 291 20 in in IN cord-019043-cqmqwl3i 291 21 approximately approximately RB cord-019043-cqmqwl3i 291 22 4 4 CD cord-019043-cqmqwl3i 291 23 - - SYM cord-019043-cqmqwl3i 291 24 8 8 CD cord-019043-cqmqwl3i 291 25 % % NN cord-019043-cqmqwl3i 291 26 of of IN cord-019043-cqmqwl3i 291 27 all all DT cord-019043-cqmqwl3i 291 28 critically critically RB cord-019043-cqmqwl3i 291 29 ill ill JJ cord-019043-cqmqwl3i 291 30 patients patient NNS cord-019043-cqmqwl3i 291 31 and and CC cord-019043-cqmqwl3i 291 32 in in IN cord-019043-cqmqwl3i 291 33 approximately approximately RB cord-019043-cqmqwl3i 291 34 70 70 CD cord-019043-cqmqwl3i 291 35 % % NN cord-019043-cqmqwl3i 291 36 of of IN cord-019043-cqmqwl3i 291 37 those those DT cord-019043-cqmqwl3i 291 38 with with IN cord-019043-cqmqwl3i 291 39 more more RBR cord-019043-cqmqwl3i 291 40 severe severe JJ cord-019043-cqmqwl3i 291 41 forms form NNS cord-019043-cqmqwl3i 291 42 of of IN cord-019043-cqmqwl3i 291 43 AKI AKI NNP cord-019043-cqmqwl3i 291 44 [ [ -LRB- cord-019043-cqmqwl3i 291 45 14 14 CD cord-019043-cqmqwl3i 291 46 ] ] -RRB- cord-019043-cqmqwl3i 291 47 . . . cord-019043-cqmqwl3i 292 1 However however RB cord-019043-cqmqwl3i 292 2 , , , cord-019043-cqmqwl3i 292 3 RRT RRT NNP cord-019043-cqmqwl3i 292 4 also also RB cord-019043-cqmqwl3i 292 5 increases increase VBZ cord-019043-cqmqwl3i 292 6 the the DT cord-019043-cqmqwl3i 292 7 complexity complexity NN cord-019043-cqmqwl3i 292 8 and and CC cord-019043-cqmqwl3i 292 9 health health NN cord-019043-cqmqwl3i 292 10 resource resource NN cord-019043-cqmqwl3i 292 11 use use NN cord-019043-cqmqwl3i 292 12 for for IN cord-019043-cqmqwl3i 292 13 critically critically RB cord-019043-cqmqwl3i 292 14 ill ill JJ cord-019043-cqmqwl3i 292 15 patients patient NNS cord-019043-cqmqwl3i 292 16 , , , cord-019043-cqmqwl3i 292 17 and and CC cord-019043-cqmqwl3i 292 18 recent recent JJ cord-019043-cqmqwl3i 292 19 data datum NNS cord-019043-cqmqwl3i 292 20 have have VBP cord-019043-cqmqwl3i 292 21 suggested suggest VBN cord-019043-cqmqwl3i 292 22 its -PRON- PRP$ cord-019043-cqmqwl3i 292 23 utilization utilization NN cord-019043-cqmqwl3i 292 24 may may MD cord-019043-cqmqwl3i 292 25 be be VB cord-019043-cqmqwl3i 292 26 associated associate VBN cord-019043-cqmqwl3i 292 27 with with IN cord-019043-cqmqwl3i 292 28 higher high JJR cord-019043-cqmqwl3i 292 29 risk risk NN cord-019043-cqmqwl3i 292 30 of of IN cord-019043-cqmqwl3i 292 31 death death NN cord-019043-cqmqwl3i 292 32 and and CC cord-019043-cqmqwl3i 292 33 dialysis dialysis NN cord-019043-cqmqwl3i 292 34 dependence dependence NN cord-019043-cqmqwl3i 292 35 among among IN cord-019043-cqmqwl3i 292 36 survivors survivor NNS cord-019043-cqmqwl3i 292 37 . . . cord-019043-cqmqwl3i 293 1 These these DT cord-019043-cqmqwl3i 293 2 data datum NNS cord-019043-cqmqwl3i 293 3 highlight highlight VBP cord-019043-cqmqwl3i 293 4 the the DT cord-019043-cqmqwl3i 293 5 existing exist VBG cord-019043-cqmqwl3i 293 6 uncertainty uncertainty NN cord-019043-cqmqwl3i 293 7 regarding regard VBG cord-019043-cqmqwl3i 293 8 many many JJ cord-019043-cqmqwl3i 293 9 aspects aspect NNS cord-019043-cqmqwl3i 293 10 of of IN cord-019043-cqmqwl3i 293 11 the the DT cord-019043-cqmqwl3i 293 12 decision decision NN cord-019043-cqmqwl3i 293 13 to to TO cord-019043-cqmqwl3i 293 14 initiate initiate VB cord-019043-cqmqwl3i 293 15 and and CC cord-019043-cqmqwl3i 293 16 process process NN cord-019043-cqmqwl3i 293 17 of of IN cord-019043-cqmqwl3i 293 18 delivery delivery NN cord-019043-cqmqwl3i 293 19 of of IN cord-019043-cqmqwl3i 293 20 RRT RRT NNP cord-019043-cqmqwl3i 293 21 to to TO cord-019043-cqmqwl3i 293 22 critically critically RB cord-019043-cqmqwl3i 293 23 ill ill VB cord-019043-cqmqwl3i 293 24 patients patient NNS cord-019043-cqmqwl3i 293 25 . . . cord-019043-cqmqwl3i 294 1 Current current JJ cord-019043-cqmqwl3i 294 2 guidelines guideline NNS cord-019043-cqmqwl3i 294 3 recommend recommend VBP cord-019043-cqmqwl3i 294 4 the the DT cord-019043-cqmqwl3i 294 5 utilization utilization NN cord-019043-cqmqwl3i 294 6 of of IN cord-019043-cqmqwl3i 294 7 an an DT cord-019043-cqmqwl3i 294 8 uncuffed uncuffed NNS cord-019043-cqmqwl3i 294 9 , , , cord-019043-cqmqwl3i 294 10 non non JJ cord-019043-cqmqwl3i 294 11 - - JJ cord-019043-cqmqwl3i 294 12 tunneled tunneled JJ cord-019043-cqmqwl3i 294 13 dialysis dialysis NN cord-019043-cqmqwl3i 294 14 catheter catheter NN cord-019043-cqmqwl3i 294 15 for for IN cord-019043-cqmqwl3i 294 16 acute acute JJ cord-019043-cqmqwl3i 294 17 RRT RRT NNP cord-019043-cqmqwl3i 294 18 in in IN cord-019043-cqmqwl3i 294 19 the the DT cord-019043-cqmqwl3i 294 20 ICU ICU NNP cord-019043-cqmqwl3i 294 21 . . . cord-019043-cqmqwl3i 295 1 The the DT cord-019043-cqmqwl3i 295 2 position position NN cord-019043-cqmqwl3i 295 3 of of IN cord-019043-cqmqwl3i 295 4 these these DT cord-019043-cqmqwl3i 295 5 acute acute JJ cord-019043-cqmqwl3i 295 6 catheters catheter NNS cord-019043-cqmqwl3i 295 7 should should MD cord-019043-cqmqwl3i 295 8 avoid avoid VB cord-019043-cqmqwl3i 295 9 insertion insertion NN cord-019043-cqmqwl3i 295 10 in in IN cord-019043-cqmqwl3i 295 11 the the DT cord-019043-cqmqwl3i 295 12 subclavian subclavian JJ cord-019043-cqmqwl3i 295 13 vessels vessel NNS cord-019043-cqmqwl3i 295 14 to to TO cord-019043-cqmqwl3i 295 15 mitigate mitigate VB cord-019043-cqmqwl3i 295 16 the the DT cord-019043-cqmqwl3i 295 17 risk risk NN cord-019043-cqmqwl3i 295 18 of of IN cord-019043-cqmqwl3i 295 19 long long JJ cord-019043-cqmqwl3i 295 20 - - HYPH cord-019043-cqmqwl3i 295 21 term term NN cord-019043-cqmqwl3i 295 22 complications complication NNS cord-019043-cqmqwl3i 295 23 such such JJ cord-019043-cqmqwl3i 295 24 as as IN cord-019043-cqmqwl3i 295 25 stenosis stenosis NN cord-019043-cqmqwl3i 295 26 / / SYM cord-019043-cqmqwl3i 295 27 thrombosis thrombosis NN cord-019043-cqmqwl3i 295 28 . . . cord-019043-cqmqwl3i 296 1 Existing exist VBG cord-019043-cqmqwl3i 296 2 tunneled tunnel VBN cord-019043-cqmqwl3i 296 3 dialysis dialysis NN cord-019043-cqmqwl3i 296 4 catheters catheter NNS cord-019043-cqmqwl3i 296 5 may may MD cord-019043-cqmqwl3i 296 6 be be VB cord-019043-cqmqwl3i 296 7 used use VBN cord-019043-cqmqwl3i 296 8 if if IN cord-019043-cqmqwl3i 296 9 already already RB cord-019043-cqmqwl3i 296 10 in in IN cord-019043-cqmqwl3i 296 11 situ situ NN cord-019043-cqmqwl3i 296 12 ; ; : cord-019043-cqmqwl3i 296 13 however however RB cord-019043-cqmqwl3i 296 14 , , , cord-019043-cqmqwl3i 296 15 use use NN cord-019043-cqmqwl3i 296 16 of of IN cord-019043-cqmqwl3i 296 17 fistulas fistula NNS cord-019043-cqmqwl3i 296 18 or or CC cord-019043-cqmqwl3i 296 19 grafts graft NNS cord-019043-cqmqwl3i 296 20 in in IN cord-019043-cqmqwl3i 296 21 acute acute JJ cord-019043-cqmqwl3i 296 22 critical critical JJ cord-019043-cqmqwl3i 296 23 care care NN cord-019043-cqmqwl3i 296 24 settings setting NNS cord-019043-cqmqwl3i 296 25 , , , cord-019043-cqmqwl3i 296 26 in in IN cord-019043-cqmqwl3i 296 27 particular particular JJ cord-019043-cqmqwl3i 296 28 for for IN cord-019043-cqmqwl3i 296 29 CRRT CRRT NNP cord-019043-cqmqwl3i 296 30 , , , cord-019043-cqmqwl3i 296 31 should should MD cord-019043-cqmqwl3i 296 32 be be VB cord-019043-cqmqwl3i 296 33 avoided avoid VBN cord-019043-cqmqwl3i 296 34 . . . cord-019043-cqmqwl3i 297 1 The the DT cord-019043-cqmqwl3i 297 2 optimal optimal JJ cord-019043-cqmqwl3i 297 3 time time NN cord-019043-cqmqwl3i 297 4 to to TO cord-019043-cqmqwl3i 297 5 start start VB cord-019043-cqmqwl3i 297 6 RRT rrt PRP cord-019043-cqmqwl3i 297 7 in in IN cord-019043-cqmqwl3i 297 8 critically critically RB cord-019043-cqmqwl3i 297 9 ill ill JJ cord-019043-cqmqwl3i 297 10 patients patient NNS cord-019043-cqmqwl3i 297 11 with with IN cord-019043-cqmqwl3i 297 12 AKI AKI NNP cord-019043-cqmqwl3i 298 1 and/or and/or CC cord-019043-cqmqwl3i 298 2 CKD CKD NNP cord-019043-cqmqwl3i 298 3 is be VBZ cord-019043-cqmqwl3i 298 4 currently currently RB cord-019043-cqmqwl3i 298 5 unknown unknown JJ cord-019043-cqmqwl3i 298 6 . . . cord-019043-cqmqwl3i 299 1 There there EX cord-019043-cqmqwl3i 299 2 is be VBZ cord-019043-cqmqwl3i 299 3 general general JJ cord-019043-cqmqwl3i 299 4 consensus consensus NN cord-019043-cqmqwl3i 299 5 that that WDT cord-019043-cqmqwl3i 299 6 RRT RRT NNP cord-019043-cqmqwl3i 299 7 should should MD cord-019043-cqmqwl3i 299 8 be be VB cord-019043-cqmqwl3i 299 9 urgently urgently RB cord-019043-cqmqwl3i 299 10 initiated initiate VBN cord-019043-cqmqwl3i 299 11 in in IN cord-019043-cqmqwl3i 299 12 the the DT cord-019043-cqmqwl3i 299 13 presence presence NN cord-019043-cqmqwl3i 299 14 of of IN cord-019043-cqmqwl3i 299 15 life life NN cord-019043-cqmqwl3i 299 16 - - HYPH cord-019043-cqmqwl3i 299 17 threatening threaten VBG cord-019043-cqmqwl3i 299 18 complications complication NNS cord-019043-cqmqwl3i 299 19 related relate VBN cord-019043-cqmqwl3i 299 20 to to IN cord-019043-cqmqwl3i 299 21 AKI AKI NNP cord-019043-cqmqwl3i 299 22 such such JJ cord-019043-cqmqwl3i 299 23 as as IN cord-019043-cqmqwl3i 299 24 severe severe JJ cord-019043-cqmqwl3i 299 25 electrolyte electrolyte JJ cord-019043-cqmqwl3i 299 26 abnormalities abnormality NNS cord-019043-cqmqwl3i 299 27 ( ( -LRB- cord-019043-cqmqwl3i 299 28 i.e. i.e. FW cord-019043-cqmqwl3i 299 29 , , , cord-019043-cqmqwl3i 299 30 hyperkalemia hyperkalemia NN cord-019043-cqmqwl3i 299 31 ) ) -RRB- cord-019043-cqmqwl3i 299 32 , , , cord-019043-cqmqwl3i 299 33 acid acid NN cord-019043-cqmqwl3i 299 34 - - HYPH cord-019043-cqmqwl3i 299 35 base base NN cord-019043-cqmqwl3i 299 36 disturbances disturbance NNS cord-019043-cqmqwl3i 299 37 ( ( -LRB- cord-019043-cqmqwl3i 299 38 i.e. i.e. FW cord-019043-cqmqwl3i 299 39 , , , cord-019043-cqmqwl3i 299 40 academia academia NN cord-019043-cqmqwl3i 299 41 ) ) -RRB- cord-019043-cqmqwl3i 299 42 , , , cord-019043-cqmqwl3i 299 43 and and CC cord-019043-cqmqwl3i 299 44 fluid fluid JJ cord-019043-cqmqwl3i 299 45 balance balance NN cord-019043-cqmqwl3i 299 46 ( ( -LRB- cord-019043-cqmqwl3i 299 47 i.e. i.e. FW cord-019043-cqmqwl3i 299 48 , , , cord-019043-cqmqwl3i 299 49 pulmonary pulmonary JJ cord-019043-cqmqwl3i 299 50 edema edema NN cord-019043-cqmqwl3i 299 51 ) ) -RRB- cord-019043-cqmqwl3i 299 52 ; ; : cord-019043-cqmqwl3i 299 53 however however RB cord-019043-cqmqwl3i 299 54 , , , cord-019043-cqmqwl3i 299 55 outside outside IN cord-019043-cqmqwl3i 299 56 of of IN cord-019043-cqmqwl3i 299 57 these these DT cord-019043-cqmqwl3i 299 58 indications indication NNS cord-019043-cqmqwl3i 299 59 , , , cord-019043-cqmqwl3i 299 60 the the DT cord-019043-cqmqwl3i 299 61 optimal optimal JJ cord-019043-cqmqwl3i 299 62 time time NN cord-019043-cqmqwl3i 299 63 to to TO cord-019043-cqmqwl3i 299 64 start start VB cord-019043-cqmqwl3i 299 65 is be VBZ cord-019043-cqmqwl3i 299 66 uncertain uncertain JJ cord-019043-cqmqwl3i 299 67 [ [ -LRB- cord-019043-cqmqwl3i 299 68 11 11 CD cord-019043-cqmqwl3i 299 69 ] ] -RRB- cord-019043-cqmqwl3i 300 1 ( ( -LRB- cord-019043-cqmqwl3i 300 2 Table Table NNP cord-019043-cqmqwl3i 300 3 32.8 32.8 CD cord-019043-cqmqwl3i 300 4 ) ) -RRB- cord-019043-cqmqwl3i 300 5 . . . cord-019043-cqmqwl3i 301 1 It -PRON- PRP cord-019043-cqmqwl3i 301 2 is be VBZ cord-019043-cqmqwl3i 301 3 likely likely RB cord-019043-cqmqwl3i 301 4 more more RBR cord-019043-cqmqwl3i 301 5 important important JJ cord-019043-cqmqwl3i 301 6 to to TO cord-019043-cqmqwl3i 301 7 evaluate evaluate VB cord-019043-cqmqwl3i 301 8 the the DT cord-019043-cqmqwl3i 301 9 broad broad JJ cord-019043-cqmqwl3i 301 10 clinical clinical JJ cord-019043-cqmqwl3i 301 11 context context NN cord-019043-cqmqwl3i 301 12 of of IN cord-019043-cqmqwl3i 301 13 critically critically RB cord-019043-cqmqwl3i 301 14 ill ill JJ cord-019043-cqmqwl3i 301 15 patients patient NNS cord-019043-cqmqwl3i 301 16 ' ' POS cord-019043-cqmqwl3i 301 17 admission admission NN cord-019043-cqmqwl3i 301 18 diagnosis diagnosis NN cord-019043-cqmqwl3i 301 19 , , , cord-019043-cqmqwl3i 301 20 illness illness NN cord-019043-cqmqwl3i 301 21 severity severity NN cord-019043-cqmqwl3i 301 22 , , , cord-019043-cqmqwl3i 301 23 non non JJ cord-019043-cqmqwl3i 301 24 - - JJ cord-019043-cqmqwl3i 301 25 kidney kidney JJ cord-019043-cqmqwl3i 301 26 organ organ NN cord-019043-cqmqwl3i 301 27 dysfunction dysfunction NN cord-019043-cqmqwl3i 301 28 , , , cord-019043-cqmqwl3i 301 29 the the DT cord-019043-cqmqwl3i 301 30 probability probability NN cord-019043-cqmqwl3i 301 31 of of IN cord-019043-cqmqwl3i 301 32 worsening worsen VBG cord-019043-cqmqwl3i 301 33 AKI AKI NNP cord-019043-cqmqwl3i 301 34 or or CC cord-019043-cqmqwl3i 301 35 non non JJ cord-019043-cqmqwl3i 301 36 - - NN cord-019043-cqmqwl3i 301 37 recovery recovery JJ cord-019043-cqmqwl3i 301 38 , , , cord-019043-cqmqwl3i 301 39 and and CC cord-019043-cqmqwl3i 301 40 additional additional JJ cord-019043-cqmqwl3i 301 41 conditions condition NNS cord-019043-cqmqwl3i 301 42 that that WDT cord-019043-cqmqwl3i 301 43 may may MD cord-019043-cqmqwl3i 301 44 be be VB cord-019043-cqmqwl3i 301 45 modified modify VBN cord-019043-cqmqwl3i 301 46 by by IN cord-019043-cqmqwl3i 301 47 RRT RRT NNP cord-019043-cqmqwl3i 301 48 ( ( -LRB- cord-019043-cqmqwl3i 301 49 i.e. i.e. FW cord-019043-cqmqwl3i 301 50 , , , cord-019043-cqmqwl3i 301 51 fluid fluid JJ cord-019043-cqmqwl3i 301 52 accumulation accumulation NN cord-019043-cqmqwl3i 301 53 ) ) -RRB- cord-019043-cqmqwl3i 301 54 rather rather RB cord-019043-cqmqwl3i 301 55 than than IN cord-019043-cqmqwl3i 301 56 reliance reliance NN cord-019043-cqmqwl3i 301 57 on on IN cord-019043-cqmqwl3i 301 58 absolute absolute JJ cord-019043-cqmqwl3i 301 59 thresholds threshold NNS cord-019043-cqmqwl3i 301 60 in in IN cord-019043-cqmqwl3i 301 61 conventional conventional JJ cord-019043-cqmqwl3i 301 62 biochemical biochemical JJ cord-019043-cqmqwl3i 301 63 markers marker NNS cord-019043-cqmqwl3i 301 64 such such JJ cord-019043-cqmqwl3i 301 65 as as IN cord-019043-cqmqwl3i 301 66 creatinine creatinine NN cord-019043-cqmqwl3i 301 67 or or CC cord-019043-cqmqwl3i 301 68 urea urea NN cord-019043-cqmqwl3i 301 69 . . . cord-019043-cqmqwl3i 302 1 Early early JJ cord-019043-cqmqwl3i 302 2 initiation initiation NN cord-019043-cqmqwl3i 302 3 of of IN cord-019043-cqmqwl3i 302 4 RRT RRT NNP cord-019043-cqmqwl3i 302 5 in in IN cord-019043-cqmqwl3i 302 6 patients patient NNS cord-019043-cqmqwl3i 302 7 with with IN cord-019043-cqmqwl3i 302 8 AKI AKI NNP cord-019043-cqmqwl3i 302 9 or or CC cord-019043-cqmqwl3i 302 10 advanced advanced JJ cord-019043-cqmqwl3i 302 11 CKD CKD NNP cord-019043-cqmqwl3i 302 12 has have VBZ cord-019043-cqmqwl3i 302 13 the the DT cord-019043-cqmqwl3i 302 14 intuitive intuitive JJ cord-019043-cqmqwl3i 302 15 appeal appeal NN cord-019043-cqmqwl3i 302 16 of of IN cord-019043-cqmqwl3i 302 17 avoiding avoid VBG cord-019043-cqmqwl3i 302 18 lifethreatening lifethreatene VBG cord-019043-cqmqwl3i 302 19 AKI AKI NNP cord-019043-cqmqwl3i 302 20 complications complication NNS cord-019043-cqmqwl3i 302 21 while while IN cord-019043-cqmqwl3i 302 22 ensuring ensure VBG cord-019043-cqmqwl3i 302 23 the the DT cord-019043-cqmqwl3i 302 24 adequate adequate JJ cord-019043-cqmqwl3i 302 25 delivery delivery NN cord-019043-cqmqwl3i 302 26 of of IN cord-019043-cqmqwl3i 302 27 essential essential JJ cord-019043-cqmqwl3i 302 28 medications medication NNS cord-019043-cqmqwl3i 302 29 ( ( -LRB- cord-019043-cqmqwl3i 302 30 i.e. i.e. FW cord-019043-cqmqwl3i 302 31 , , , cord-019043-cqmqwl3i 302 32 antimicrobials antimicrobial NNS cord-019043-cqmqwl3i 302 33 ) ) -RRB- cord-019043-cqmqwl3i 302 34 and and CC cord-019043-cqmqwl3i 302 35 nutrition nutrition NN cord-019043-cqmqwl3i 302 36 and and CC cord-019043-cqmqwl3i 302 37 transfusion transfusion NN cord-019043-cqmqwl3i 302 38 support support NN cord-019043-cqmqwl3i 302 39 without without IN cord-019043-cqmqwl3i 302 40 concern concern NN cord-019043-cqmqwl3i 302 41 for for IN cord-019043-cqmqwl3i 302 42 excessive excessive JJ cord-019043-cqmqwl3i 302 43 fluid fluid JJ cord-019043-cqmqwl3i 302 44 accumulation accumulation NN cord-019043-cqmqwl3i 302 45 . . . cord-019043-cqmqwl3i 303 1 Recent recent JJ cord-019043-cqmqwl3i 303 2 systematic systematic JJ cord-019043-cqmqwl3i 303 3 reviews review NNS cord-019043-cqmqwl3i 303 4 have have VBP cord-019043-cqmqwl3i 303 5 supported support VBN cord-019043-cqmqwl3i 303 6 this this DT cord-019043-cqmqwl3i 303 7 concept concept NN cord-019043-cqmqwl3i 303 8 , , , cord-019043-cqmqwl3i 303 9 suggesting suggest VBG cord-019043-cqmqwl3i 303 10 earlier early RBR cord-019043-cqmqwl3i 303 11 RRT RRT NNP cord-019043-cqmqwl3i 303 12 initiation initiation NN cord-019043-cqmqwl3i 303 13 may may MD cord-019043-cqmqwl3i 303 14 improve improve VB cord-019043-cqmqwl3i 303 15 survival survival NN cord-019043-cqmqwl3i 303 16 ; ; : cord-019043-cqmqwl3i 303 17 however however RB cord-019043-cqmqwl3i 303 18 , , , cord-019043-cqmqwl3i 303 19 studies study NNS cord-019043-cqmqwl3i 303 20 included include VBN cord-019043-cqmqwl3i 303 21 in in IN cord-019043-cqmqwl3i 303 22 these these DT cord-019043-cqmqwl3i 303 23 analyses analysis NNS cord-019043-cqmqwl3i 303 24 were be VBD cord-019043-cqmqwl3i 303 25 highly highly RB cord-019043-cqmqwl3i 303 26 susceptible susceptible JJ cord-019043-cqmqwl3i 303 27 to to IN cord-019043-cqmqwl3i 303 28 bias bias NN cord-019043-cqmqwl3i 303 29 [ [ -LRB- cord-019043-cqmqwl3i 303 30 17 17 CD cord-019043-cqmqwl3i 303 31 , , , cord-019043-cqmqwl3i 303 32 18 18 CD cord-019043-cqmqwl3i 303 33 ] ] -RRB- cord-019043-cqmqwl3i 303 34 . . . cord-019043-cqmqwl3i 304 1 The the DT cord-019043-cqmqwl3i 304 2 choice choice NN cord-019043-cqmqwl3i 304 3 of of IN cord-019043-cqmqwl3i 304 4 ideal ideal JJ cord-019043-cqmqwl3i 304 5 RRT rrt NN cord-019043-cqmqwl3i 304 6 modality modality NN cord-019043-cqmqwl3i 304 7 for for IN cord-019043-cqmqwl3i 304 8 critically critically RB cord-019043-cqmqwl3i 304 9 ill ill JJ cord-019043-cqmqwl3i 304 10 patients patient NNS cord-019043-cqmqwl3i 304 11 has have VBZ cord-019043-cqmqwl3i 304 12 long long RB cord-019043-cqmqwl3i 304 13 been be VBN cord-019043-cqmqwl3i 304 14 debated debate VBN cord-019043-cqmqwl3i 304 15 . . . cord-019043-cqmqwl3i 305 1 Systematic systematic JJ cord-019043-cqmqwl3i 305 2 reviews review NNS cord-019043-cqmqwl3i 305 3 have have VBP cord-019043-cqmqwl3i 305 4 not not RB cord-019043-cqmqwl3i 305 5 shown show VBN cord-019043-cqmqwl3i 305 6 a a DT cord-019043-cqmqwl3i 305 7 clear clear JJ cord-019043-cqmqwl3i 305 8 survival survival NN cord-019043-cqmqwl3i 305 9 advantage advantage NN cord-019043-cqmqwl3i 305 10 Monitor monitor VBP cord-019043-cqmqwl3i 305 11 daily daily RB cord-019043-cqmqwl3i 305 12 fluid fluid JJ cord-019043-cqmqwl3i 305 13 intake intake NN cord-019043-cqmqwl3i 305 14 / / SYM cord-019043-cqmqwl3i 305 15 output output NN cord-019043-cqmqwl3i 305 16 and and CC cord-019043-cqmqwl3i 305 17 daily daily JJ cord-019043-cqmqwl3i 305 18 / / SYM cord-019043-cqmqwl3i 305 19 cumulative cumulative JJ cord-019043-cqmqwl3i 305 20 fluid fluid JJ cord-019043-cqmqwl3i 305 21 balance balance NN cord-019043-cqmqwl3i 305 22 , , , cord-019043-cqmqwl3i 305 23 recognizing recognize VBG cord-019043-cqmqwl3i 305 24 there there EX cord-019043-cqmqwl3i 305 25 is be VBZ cord-019043-cqmqwl3i 305 26 some some DT cord-019043-cqmqwl3i 305 27 " " `` cord-019043-cqmqwl3i 305 28 ebb ebb VB cord-019043-cqmqwl3i 305 29 and and CC cord-019043-cqmqwl3i 305 30 flow flow NN cord-019043-cqmqwl3i 305 31 " " '' cord-019043-cqmqwl3i 305 32 to to IN cord-019043-cqmqwl3i 305 33 fluid fluid JJ cord-019043-cqmqwl3i 305 34 balance balance NN cord-019043-cqmqwl3i 305 35 in in IN cord-019043-cqmqwl3i 305 36 critical critical JJ cord-019043-cqmqwl3i 305 37 illness illness NN cord-019043-cqmqwl3i 305 38 Monitor Monitor NNP cord-019043-cqmqwl3i 305 39 for for IN cord-019043-cqmqwl3i 305 40 / / SYM cord-019043-cqmqwl3i 305 41 avoid avoid VB cord-019043-cqmqwl3i 305 42 complications complication NNS cord-019043-cqmqwl3i 305 43 of of IN cord-019043-cqmqwl3i 305 44 overt overt JJ cord-019043-cqmqwl3i 305 45 kidney kidney NN cord-019043-cqmqwl3i 305 46 failure failure NN cord-019043-cqmqwl3i 305 47 Monitor Monitor NNP cord-019043-cqmqwl3i 305 48 AKI AKI NNP cord-019043-cqmqwl3i 305 49 and and CC cord-019043-cqmqwl3i 305 50 CKD CKD NNP cord-019043-cqmqwl3i 305 51 patients patient NNS cord-019043-cqmqwl3i 305 52 for for IN cord-019043-cqmqwl3i 305 53 serious serious JJ cord-019043-cqmqwl3i 305 54 complications complication NNS cord-019043-cqmqwl3i 305 55 such such JJ cord-019043-cqmqwl3i 305 56 as as IN cord-019043-cqmqwl3i 305 57 hyperkalemia hyperkalemia NN cord-019043-cqmqwl3i 305 58 , , , cord-019043-cqmqwl3i 305 59 acidemia acidemia NN cord-019043-cqmqwl3i 305 60 , , , cord-019043-cqmqwl3i 305 61 fluid fluid JJ cord-019043-cqmqwl3i 305 62 overload overload NN cord-019043-cqmqwl3i 305 63 , , , cord-019043-cqmqwl3i 305 64 and and CC cord-019043-cqmqwl3i 305 65 drug drug NN cord-019043-cqmqwl3i 305 66 toxicities toxicity NNS cord-019043-cqmqwl3i 305 67 and and CC cord-019043-cqmqwl3i 305 68 appropriately appropriately RB cord-019043-cqmqwl3i 305 69 plan plan VBP cord-019043-cqmqwl3i 305 70 for for IN cord-019043-cqmqwl3i 305 71 RRT RRT NNP cord-019043-cqmqwl3i 306 1 Maintain maintain VB cord-019043-cqmqwl3i 307 1 glycemic glycemic NNP cord-019043-cqmqwl3i 307 2 control control NNP cord-019043-cqmqwl3i 307 3 Glycemic Glycemic NNP cord-019043-cqmqwl3i 307 4 control control NN cord-019043-cqmqwl3i 307 5 has have VBZ cord-019043-cqmqwl3i 307 6 been be VBN cord-019043-cqmqwl3i 307 7 associated associate VBN cord-019043-cqmqwl3i 307 8 with with IN cord-019043-cqmqwl3i 307 9 reduced reduce VBN cord-019043-cqmqwl3i 307 10 incidence incidence NN cord-019043-cqmqwl3i 307 11 of of IN cord-019043-cqmqwl3i 307 12 AKI AKI NNP cord-019043-cqmqwl3i 307 13 and and CC cord-019043-cqmqwl3i 307 14 lower low JJR cord-019043-cqmqwl3i 307 15 utilization utilization NN cord-019043-cqmqwl3i 307 16 of of IN cord-019043-cqmqwl3i 307 17 RRT RRT NNP cord-019043-cqmqwl3i 307 18 . . . cord-019043-cqmqwl3i 308 1 The the DT cord-019043-cqmqwl3i 308 2 balance balance NN cord-019043-cqmqwl3i 308 3 of of IN cord-019043-cqmqwl3i 308 4 evidence evidence NN cord-019043-cqmqwl3i 308 5 now now RB cord-019043-cqmqwl3i 308 6 recommends recommend VBZ cord-019043-cqmqwl3i 308 7 maintaining maintain VBG cord-019043-cqmqwl3i 308 8 glycemic glycemic JJ cord-019043-cqmqwl3i 308 9 control control NN cord-019043-cqmqwl3i 308 10 with with IN cord-019043-cqmqwl3i 308 11 a a DT cord-019043-cqmqwl3i 308 12 target target NN cord-019043-cqmqwl3i 308 13 blood blood NN cord-019043-cqmqwl3i 308 14 glucose glucose NN cord-019043-cqmqwl3i 308 15 ( ( -LRB- cord-019043-cqmqwl3i 308 16 BG BG NNP cord-019043-cqmqwl3i 308 17 ) ) -RRB- cord-019043-cqmqwl3i 308 18 of of IN cord-019043-cqmqwl3i 308 19 6.1 6.1 CD cord-019043-cqmqwl3i 308 20 - - HYPH cord-019043-cqmqwl3i 308 21 10.0 10.0 CD cord-019043-cqmqwl3i 308 22 mmol mmol NNP cord-019043-cqmqwl3i 308 23 / / SYM cord-019043-cqmqwl3i 308 24 L L NNP cord-019043-cqmqwl3i 308 25 ( ( -LRB- cord-019043-cqmqwl3i 308 26 110 110 CD cord-019043-cqmqwl3i 308 27 - - SYM cord-019043-cqmqwl3i 308 28 180 180 CD cord-019043-cqmqwl3i 308 29 mg mg NNP cord-019043-cqmqwl3i 308 30 / / SYM cord-019043-cqmqwl3i 308 31 dL dl NN cord-019043-cqmqwl3i 308 32 ) ) -RRB- cord-019043-cqmqwl3i 308 33 rather rather RB cord-019043-cqmqwl3i 308 34 than than IN cord-019043-cqmqwl3i 308 35 using use VBG cord-019043-cqmqwl3i 308 36 intensive intensive JJ cord-019043-cqmqwl3i 308 37 insulin insulin NN cord-019043-cqmqwl3i 308 38 therapy therapy NN cord-019043-cqmqwl3i 308 39 ( ( -LRB- cord-019043-cqmqwl3i 308 40 IIT IIT NNP cord-019043-cqmqwl3i 308 41 ) ) -RRB- cord-019043-cqmqwl3i 308 42 to to TO cord-019043-cqmqwl3i 308 43 maintain maintain VB cord-019043-cqmqwl3i 308 44 tight tight JJ cord-019043-cqmqwl3i 308 45 glycemic glycemic JJ cord-019043-cqmqwl3i 308 46 control control NN cord-019043-cqmqwl3i 308 47 , , , cord-019043-cqmqwl3i 308 48 with with IN cord-019043-cqmqwl3i 308 49 BG BG NNP cord-019043-cqmqwl3i 308 50 of of IN cord-019043-cqmqwl3i 308 51 4.4 4.4 CD cord-019043-cqmqwl3i 308 52 - - SYM cord-019043-cqmqwl3i 308 53 6.0 6.0 CD cord-019043-cqmqwl3i 308 54 mmol mmol NN cord-019043-cqmqwl3i 308 55 / / SYM cord-019043-cqmqwl3i 308 56 L L NNP cord-019043-cqmqwl3i 308 57 ( ( -LRB- cord-019043-cqmqwl3i 308 58 80 80 CD cord-019043-cqmqwl3i 308 59 - - SYM cord-019043-cqmqwl3i 308 60 110 110 CD cord-019043-cqmqwl3i 308 61 mg mg NNP cord-019043-cqmqwl3i 308 62 / / SYM cord-019043-cqmqwl3i 308 63 dL dl NN cord-019043-cqmqwl3i 308 64 ) ) -RRB- cord-019043-cqmqwl3i 308 65 , , , cord-019043-cqmqwl3i 308 66 due due IN cord-019043-cqmqwl3i 308 67 to to IN cord-019043-cqmqwl3i 308 68 the the DT cord-019043-cqmqwl3i 308 69 increased increase VBN cord-019043-cqmqwl3i 308 70 risk risk NN cord-019043-cqmqwl3i 308 71 of of IN cord-019043-cqmqwl3i 308 72 hypoglycemia hypoglycemia NN cord-019043-cqmqwl3i 308 73 a a DT cord-019043-cqmqwl3i 308 74 There there EX cord-019043-cqmqwl3i 308 75 should should MD cord-019043-cqmqwl3i 308 76 be be VB cord-019043-cqmqwl3i 308 77 early early JJ cord-019043-cqmqwl3i 308 78 use use NN cord-019043-cqmqwl3i 308 79 of of IN cord-019043-cqmqwl3i 308 80 invasive invasive JJ cord-019043-cqmqwl3i 308 81 / / SYM cord-019043-cqmqwl3i 308 82 functional functional JJ cord-019043-cqmqwl3i 308 83 hemodynamic hemodynamic JJ cord-019043-cqmqwl3i 308 84 monitoring monitoring NN cord-019043-cqmqwl3i 308 85 ( ( -LRB- cord-019043-cqmqwl3i 308 86 i.e. i.e. FW cord-019043-cqmqwl3i 308 87 , , , cord-019043-cqmqwl3i 308 88 arterial arterial JJ cord-019043-cqmqwl3i 308 89 catheter catheter NN cord-019043-cqmqwl3i 308 90 , , , cord-019043-cqmqwl3i 308 91 central central JJ cord-019043-cqmqwl3i 308 92 venous venous JJ cord-019043-cqmqwl3i 308 93 pressure pressure NN cord-019043-cqmqwl3i 308 94 , , , cord-019043-cqmqwl3i 308 95 echocardiography echocardiography NN cord-019043-cqmqwl3i 308 96 , , , cord-019043-cqmqwl3i 308 97 pulmonary pulmonary JJ cord-019043-cqmqwl3i 308 98 artery artery NN cord-019043-cqmqwl3i 308 99 catheter catheter NN cord-019043-cqmqwl3i 308 100 , , , cord-019043-cqmqwl3i 308 101 or or CC cord-019043-cqmqwl3i 308 102 methods method NNS cord-019043-cqmqwl3i 308 103 to to TO cord-019043-cqmqwl3i 308 104 measure measure VB cord-019043-cqmqwl3i 308 105 stroke stroke NN cord-019043-cqmqwl3i 308 106 volume volume NN cord-019043-cqmqwl3i 308 107 or or CC cord-019043-cqmqwl3i 308 108 pulse pulse NN cord-019043-cqmqwl3i 308 109 pressure pressure NN cord-019043-cqmqwl3i 308 110 variation variation NN cord-019043-cqmqwl3i 308 111 ) ) -RRB- cord-019043-cqmqwl3i 308 112 for for IN cord-019043-cqmqwl3i 308 113 one one CD cord-019043-cqmqwl3i 308 114 modality modality NN cord-019043-cqmqwl3i 308 115 , , , cord-019043-cqmqwl3i 308 116 continuous continuous JJ cord-019043-cqmqwl3i 308 117 RRT RRT NNP cord-019043-cqmqwl3i 308 118 ( ( -LRB- cord-019043-cqmqwl3i 308 119 CRRT CRRT NNP cord-019043-cqmqwl3i 308 120 ) ) -RRB- cord-019043-cqmqwl3i 308 121 , , , cord-019043-cqmqwl3i 308 122 slow slow JJ cord-019043-cqmqwl3i 308 123 low low JJ cord-019043-cqmqwl3i 308 124 - - HYPH cord-019043-cqmqwl3i 308 125 efficiency efficiency NN cord-019043-cqmqwl3i 308 126 dialysis dialysis NN cord-019043-cqmqwl3i 308 127 ( ( -LRB- cord-019043-cqmqwl3i 308 128 SLED SLED NNP cord-019043-cqmqwl3i 308 129 ) ) -RRB- cord-019043-cqmqwl3i 308 130 , , , cord-019043-cqmqwl3i 308 131 or or CC cord-019043-cqmqwl3i 308 132 intermittent intermittent JJ cord-019043-cqmqwl3i 308 133 RRT rrt NN cord-019043-cqmqwl3i 308 134 ( ( -LRB- cord-019043-cqmqwl3i 308 135 IRRT IRRT NNP cord-019043-cqmqwl3i 308 136 ) ) -RRB- cord-019043-cqmqwl3i 308 137 , , , cord-019043-cqmqwl3i 308 138 over over IN cord-019043-cqmqwl3i 308 139 another another DT cord-019043-cqmqwl3i 308 140 in in IN cord-019043-cqmqwl3i 308 141 critically critically RB cord-019043-cqmqwl3i 308 142 ill ill JJ cord-019043-cqmqwl3i 308 143 patients patient NNS cord-019043-cqmqwl3i 308 144 with with IN cord-019043-cqmqwl3i 308 145 AKI AKI NNP cord-019043-cqmqwl3i 308 146 [ [ -LRB- cord-019043-cqmqwl3i 308 147 19 19 CD cord-019043-cqmqwl3i 308 148 ] ] -RRB- cord-019043-cqmqwl3i 309 1 ( ( -LRB- cord-019043-cqmqwl3i 309 2 Table Table NNP cord-019043-cqmqwl3i 309 3 32 32 CD cord-019043-cqmqwl3i 309 4 . . . cord-019043-cqmqwl3i 309 5 9 9 CD cord-019043-cqmqwl3i 309 6 ) ) -RRB- cord-019043-cqmqwl3i 309 7 . . . cord-019043-cqmqwl3i 310 1 Ideally ideally RB cord-019043-cqmqwl3i 310 2 , , , cord-019043-cqmqwl3i 310 3 the the DT cord-019043-cqmqwl3i 310 4 modality modality NN cord-019043-cqmqwl3i 310 5 chosen choose VBN cord-019043-cqmqwl3i 310 6 should should MD cord-019043-cqmqwl3i 310 7 suit suit VB cord-019043-cqmqwl3i 310 8 the the DT cord-019043-cqmqwl3i 310 9 patient patient NN cord-019043-cqmqwl3i 310 10 's 's POS cord-019043-cqmqwl3i 310 11 acute acute JJ cord-019043-cqmqwl3i 310 12 physiology physiology NN cord-019043-cqmqwl3i 310 13 and and CC cord-019043-cqmqwl3i 310 14 therapeutic therapeutic JJ cord-019043-cqmqwl3i 310 15 objectives objective NNS cord-019043-cqmqwl3i 310 16 while while IN cord-019043-cqmqwl3i 310 17 avoiding avoid VBG cord-019043-cqmqwl3i 310 18 treatment treatment NN cord-019043-cqmqwl3i 310 19 - - HYPH cord-019043-cqmqwl3i 310 20 related relate VBN cord-019043-cqmqwl3i 310 21 complications complication NNS cord-019043-cqmqwl3i 310 22 . . . cord-019043-cqmqwl3i 311 1 CRRT CRRT NNP cord-019043-cqmqwl3i 311 2 is be VBZ cord-019043-cqmqwl3i 311 3 the the DT cord-019043-cqmqwl3i 311 4 preferred preferred JJ cord-019043-cqmqwl3i 311 5 modality modality NN cord-019043-cqmqwl3i 311 6 in in IN cord-019043-cqmqwl3i 311 7 hemodynamically hemodynamically RB cord-019043-cqmqwl3i 311 8 unstable unstable JJ cord-019043-cqmqwl3i 311 9 patients patient NNS cord-019043-cqmqwl3i 311 10 and and CC cord-019043-cqmqwl3i 311 11 those those DT cord-019043-cqmqwl3i 311 12 with with IN cord-019043-cqmqwl3i 311 13 acute acute JJ cord-019043-cqmqwl3i 311 14 brain brain NN cord-019043-cqmqwl3i 311 15 injury injury NN cord-019043-cqmqwl3i 311 16 or or CC cord-019043-cqmqwl3i 311 17 fulminant fulminant JJ cord-019043-cqmqwl3i 311 18 hepatic hepatic JJ cord-019043-cqmqwl3i 311 19 failure failure NN cord-019043-cqmqwl3i 311 20 and and CC cord-019043-cqmqwl3i 311 21 at at IN cord-019043-cqmqwl3i 311 22 risk risk NN cord-019043-cqmqwl3i 311 23 for for IN cord-019043-cqmqwl3i 311 24 intracranial intracranial JJ cord-019043-cqmqwl3i 311 25 hypertension hypertension NN cord-019043-cqmqwl3i 311 26 and and CC cord-019043-cqmqwl3i 311 27 cerebral cerebral JJ cord-019043-cqmqwl3i 311 28 edema edema NN cord-019043-cqmqwl3i 311 29 [ [ -LRB- cord-019043-cqmqwl3i 311 30 11 11 CD cord-019043-cqmqwl3i 311 31 ] ] -RRB- cord-019043-cqmqwl3i 311 32 . . . cord-019043-cqmqwl3i 312 1 CRRT CRRT NNP cord-019043-cqmqwl3i 312 2 has have VBZ cord-019043-cqmqwl3i 312 3 also also RB cord-019043-cqmqwl3i 312 4 been be VBN cord-019043-cqmqwl3i 312 5 shown show VBN cord-019043-cqmqwl3i 312 6 superior superior JJ cord-019043-cqmqwl3i 312 7 for for IN cord-019043-cqmqwl3i 312 8 maintaining maintain VBG cord-019043-cqmqwl3i 312 9 fluid fluid JJ cord-019043-cqmqwl3i 312 10 homeostasis homeostasis NN cord-019043-cqmqwl3i 312 11 and and CC cord-019043-cqmqwl3i 312 12 mitigating mitigate VBG cord-019043-cqmqwl3i 312 13 fluid fluid JJ cord-019043-cqmqwl3i 312 14 overload overload NN cord-019043-cqmqwl3i 312 15 . . . cord-019043-cqmqwl3i 313 1 A a DT cord-019043-cqmqwl3i 313 2 recent recent JJ cord-019043-cqmqwl3i 313 3 systematic systematic JJ cord-019043-cqmqwl3i 313 4 review review NN cord-019043-cqmqwl3i 313 5 suggested suggest VBD cord-019043-cqmqwl3i 313 6 that that IN cord-019043-cqmqwl3i 313 7 initial initial JJ cord-019043-cqmqwl3i 313 8 therapy therapy NN cord-019043-cqmqwl3i 313 9 with with IN cord-019043-cqmqwl3i 313 10 CRRT CRRT NNP cord-019043-cqmqwl3i 313 11 in in IN cord-019043-cqmqwl3i 313 12 critically critically RB cord-019043-cqmqwl3i 313 13 ill ill JJ cord-019043-cqmqwl3i 313 14 patients patient NNS cord-019043-cqmqwl3i 313 15 is be VBZ cord-019043-cqmqwl3i 313 16 associated associate VBN cord-019043-cqmqwl3i 313 17 with with IN cord-019043-cqmqwl3i 313 18 lower low JJR cord-019043-cqmqwl3i 313 19 rates rate NNS cord-019043-cqmqwl3i 313 20 of of IN cord-019043-cqmqwl3i 313 21 dialysis dialysis NN cord-019043-cqmqwl3i 313 22 dependence dependence NN cord-019043-cqmqwl3i 313 23 among among IN cord-019043-cqmqwl3i 313 24 survivors survivor NNS cord-019043-cqmqwl3i 313 25 when when WRB cord-019043-cqmqwl3i 313 26 compared compare VBN cord-019043-cqmqwl3i 313 27 with with IN cord-019043-cqmqwl3i 313 28 IRRT IRRT NNP cord-019043-cqmqwl3i 313 29 [ [ -LRB- cord-019043-cqmqwl3i 313 30 20 20 CD cord-019043-cqmqwl3i 313 31 ] ] -RRB- cord-019043-cqmqwl3i 313 32 . . . cord-019043-cqmqwl3i 314 1 These these DT cord-019043-cqmqwl3i 314 2 data datum NNS cord-019043-cqmqwl3i 314 3 may may MD cord-019043-cqmqwl3i 314 4 imply imply VB cord-019043-cqmqwl3i 314 5 CRRT CRRT NNP cord-019043-cqmqwl3i 314 6 may may MD cord-019043-cqmqwl3i 314 7 be be VB cord-019043-cqmqwl3i 314 8 the the DT cord-019043-cqmqwl3i 314 9 preferred preferred JJ cord-019043-cqmqwl3i 314 10 initial initial JJ cord-019043-cqmqwl3i 314 11 modality modality NN cord-019043-cqmqwl3i 314 12 for for IN cord-019043-cqmqwl3i 314 13 surviving survive VBG cord-019043-cqmqwl3i 314 14 critically critically RB cord-019043-cqmqwl3i 314 15 ill ill JJ cord-019043-cqmqwl3i 314 16 patients patient NNS cord-019043-cqmqwl3i 314 17 at at IN cord-019043-cqmqwl3i 314 18 increased increase VBN cord-019043-cqmqwl3i 314 19 risk risk NN cord-019043-cqmqwl3i 314 20 for for IN cord-019043-cqmqwl3i 314 21 incident incident NN cord-019043-cqmqwl3i 314 22 or or CC cord-019043-cqmqwl3i 314 23 worsening worsen VBG cord-019043-cqmqwl3i 314 24 CKD CKD NNP cord-019043-cqmqwl3i 314 25 ( ( -LRB- cord-019043-cqmqwl3i 314 26 i.e. i.e. FW cord-019043-cqmqwl3i 314 27 , , , cord-019043-cqmqwl3i 314 28 those those DT cord-019043-cqmqwl3i 314 29 with with IN cord-019043-cqmqwl3i 314 30 baseline baseline JJ cord-019043-cqmqwl3i 314 31 CKD CKD NNP cord-019043-cqmqwl3i 314 32 ) ) -RRB- cord-019043-cqmqwl3i 314 33 . . . cord-019043-cqmqwl3i 315 1 The the DT cord-019043-cqmqwl3i 315 2 optimal optimal JJ cord-019043-cqmqwl3i 315 3 mode mode NN cord-019043-cqmqwl3i 315 4 of of IN cord-019043-cqmqwl3i 315 5 CRRT CRRT NNP cord-019043-cqmqwl3i 315 6 to to TO cord-019043-cqmqwl3i 315 7 improve improve VB cord-019043-cqmqwl3i 315 8 outcome outcome NN cord-019043-cqmqwl3i 315 9 remains remain VBZ cord-019043-cqmqwl3i 315 10 uncertain uncertain JJ cord-019043-cqmqwl3i 315 11 . . . cord-019043-cqmqwl3i 316 1 The the DT cord-019043-cqmqwl3i 316 2 purported purport VBN cord-019043-cqmqwl3i 316 3 advantages advantage NNS cord-019043-cqmqwl3i 316 4 to to IN cord-019043-cqmqwl3i 316 5 hemofiltration hemofiltration NN cord-019043-cqmqwl3i 316 6 ( ( -LRB- cord-019043-cqmqwl3i 316 7 CVVH CVVH NNP cord-019043-cqmqwl3i 316 8 ) ) -RRB- cord-019043-cqmqwl3i 316 9 compared compare VBN cord-019043-cqmqwl3i 316 10 with with IN cord-019043-cqmqwl3i 316 11 hemodialysis hemodialysis NN cord-019043-cqmqwl3i 316 12 ( ( -LRB- cord-019043-cqmqwl3i 316 13 CVVHD CVVHD NNP cord-019043-cqmqwl3i 316 14 ) ) -RRB- cord-019043-cqmqwl3i 316 15 are be VBP cord-019043-cqmqwl3i 316 16 the the DT cord-019043-cqmqwl3i 316 17 improved improve VBN cord-019043-cqmqwl3i 316 18 convective convective JJ cord-019043-cqmqwl3i 316 19 clearance clearance NN cord-019043-cqmqwl3i 316 20 of of IN cord-019043-cqmqwl3i 316 21 middle middle JJ cord-019043-cqmqwl3i 316 22 molecular molecular JJ cord-019043-cqmqwl3i 316 23 weight weight NN cord-019043-cqmqwl3i 316 24 solutes solute NNS cord-019043-cqmqwl3i 316 25 such such JJ cord-019043-cqmqwl3i 316 26 as as IN cord-019043-cqmqwl3i 316 27 inflammatory inflammatory JJ cord-019043-cqmqwl3i 316 28 and and CC cord-019043-cqmqwl3i 316 29 toxic toxic JJ cord-019043-cqmqwl3i 316 30 mediators mediator NNS cord-019043-cqmqwl3i 316 31 . . . cord-019043-cqmqwl3i 317 1 Recent recent JJ cord-019043-cqmqwl3i 317 2 data datum NNS cord-019043-cqmqwl3i 317 3 have have VBP cord-019043-cqmqwl3i 317 4 suggested suggest VBN cord-019043-cqmqwl3i 317 5 equivalent equivalent JJ cord-019043-cqmqwl3i 317 6 outcomes outcome NNS cord-019043-cqmqwl3i 317 7 in in IN cord-019043-cqmqwl3i 317 8 terms term NNS cord-019043-cqmqwl3i 317 9 of of IN cord-019043-cqmqwl3i 317 10 survival survival NN cord-019043-cqmqwl3i 317 11 and and CC cord-019043-cqmqwl3i 317 12 recovery recovery NN cord-019043-cqmqwl3i 317 13 of of IN cord-019043-cqmqwl3i 317 14 kidney kidney NN cord-019043-cqmqwl3i 317 15 function function NN cord-019043-cqmqwl3i 317 16 ; ; : cord-019043-cqmqwl3i 317 17 however however RB cord-019043-cqmqwl3i 317 18 , , , cord-019043-cqmqwl3i 317 19 CVVH CVVH NNP cord-019043-cqmqwl3i 317 20 may may MD cord-019043-cqmqwl3i 317 21 be be VB cord-019043-cqmqwl3i 317 22 associated associate VBN cord-019043-cqmqwl3i 317 23 with with IN cord-019043-cqmqwl3i 317 24 short short JJ cord-019043-cqmqwl3i 317 25 filter filter NN cord-019043-cqmqwl3i 317 26 lifespan lifespan NN cord-019043-cqmqwl3i 317 27 compared compare VBN cord-019043-cqmqwl3i 317 28 with with IN cord-019043-cqmqwl3i 317 29 CVVHD CVVHD NNP cord-019043-cqmqwl3i 317 30 [ [ -LRB- cord-019043-cqmqwl3i 317 31 21 21 CD cord-019043-cqmqwl3i 317 32 ] ] -RRB- cord-019043-cqmqwl3i 317 33 . . . cord-019043-cqmqwl3i 318 1 The the DT cord-019043-cqmqwl3i 318 2 optimal optimal JJ cord-019043-cqmqwl3i 318 3 time time NN cord-019043-cqmqwl3i 318 4 to to TO cord-019043-cqmqwl3i 318 5 transition transition NN cord-019043-cqmqwl3i 318 6 from from IN cord-019043-cqmqwl3i 318 7 CRRT CRRT NNP cord-019043-cqmqwl3i 318 8 to to IN cord-019043-cqmqwl3i 318 9 either either CC cord-019043-cqmqwl3i 318 10 SLED SLED NNP cord-019043-cqmqwl3i 318 11 or or CC cord-019043-cqmqwl3i 318 12 IRRT IRRT NNP cord-019043-cqmqwl3i 318 13 is be VBZ cord-019043-cqmqwl3i 318 14 currently currently RB cord-019043-cqmqwl3i 318 15 unknown unknown JJ cord-019043-cqmqwl3i 318 16 ; ; : cord-019043-cqmqwl3i 318 17 however however RB cord-019043-cqmqwl3i 318 18 , , , cord-019043-cqmqwl3i 318 19 it -PRON- PRP cord-019043-cqmqwl3i 318 20 pragmatically pragmatically RB cord-019043-cqmqwl3i 318 21 will will MD cord-019043-cqmqwl3i 318 22 coincide coincide VB cord-019043-cqmqwl3i 318 23 with with IN cord-019043-cqmqwl3i 318 24 physiologic physiologic JJ cord-019043-cqmqwl3i 318 25 stabilization stabilization NN cord-019043-cqmqwl3i 318 26 and and CC cord-019043-cqmqwl3i 318 27 following follow VBG cord-019043-cqmqwl3i 318 28 weaning wean VBG cord-019043-cqmqwl3i 318 29 from from IN cord-019043-cqmqwl3i 318 30 vasoactive vasoactive JJ cord-019043-cqmqwl3i 318 31 support support NN cord-019043-cqmqwl3i 318 32 . . . cord-019043-cqmqwl3i 319 1 The the DT cord-019043-cqmqwl3i 319 2 utilization utilization NN cord-019043-cqmqwl3i 319 3 of of IN cord-019043-cqmqwl3i 319 4 peritoneal peritoneal JJ cord-019043-cqmqwl3i 319 5 dialysis dialysis NN cord-019043-cqmqwl3i 319 6 in in IN cord-019043-cqmqwl3i 319 7 critical critical JJ cord-019043-cqmqwl3i 319 8 illness illness NN cord-019043-cqmqwl3i 319 9 may may MD cord-019043-cqmqwl3i 319 10 be be VB cord-019043-cqmqwl3i 319 11 impractical impractical JJ cord-019043-cqmqwl3i 319 12 and and CC cord-019043-cqmqwl3i 319 13 result result VB cord-019043-cqmqwl3i 319 14 in in IN cord-019043-cqmqwl3i 319 15 insufficient insufficient JJ cord-019043-cqmqwl3i 319 16 solute solute NN cord-019043-cqmqwl3i 319 17 clearance clearance NN cord-019043-cqmqwl3i 319 18 in in IN cord-019043-cqmqwl3i 319 19 catabolic catabolic JJ cord-019043-cqmqwl3i 319 20 patients patient NNS cord-019043-cqmqwl3i 319 21 and and CC cord-019043-cqmqwl3i 319 22 inadequate inadequate JJ cord-019043-cqmqwl3i 319 23 fluid fluid NN cord-019043-cqmqwl3i 319 24 removal removal NN cord-019043-cqmqwl3i 319 25 . . . cord-019043-cqmqwl3i 320 1 These these DT cord-019043-cqmqwl3i 320 2 factors factor NNS cord-019043-cqmqwl3i 320 3 may may MD cord-019043-cqmqwl3i 320 4 have have VB cord-019043-cqmqwl3i 320 5 contributed contribute VBN cord-019043-cqmqwl3i 320 6 to to IN cord-019043-cqmqwl3i 320 7 the the DT cord-019043-cqmqwl3i 320 8 observation observation NN cord-019043-cqmqwl3i 320 9 of of IN cord-019043-cqmqwl3i 320 10 higher high JJR cord-019043-cqmqwl3i 320 11 mortality mortality NN cord-019043-cqmqwl3i 320 12 for for IN cord-019043-cqmqwl3i 320 13 critically critically RB cord-019043-cqmqwl3i 320 14 ill ill JJ cord-019043-cqmqwl3i 320 15 patients patient NNS cord-019043-cqmqwl3i 320 16 treated treat VBN cord-019043-cqmqwl3i 320 17 with with IN cord-019043-cqmqwl3i 320 18 ACEi ACEi NNS cord-019043-cqmqwl3i 320 19 and and CC cord-019043-cqmqwl3i 320 20 ARB ARB NNP cord-019043-cqmqwl3i 320 21 lead lead NN cord-019043-cqmqwl3i 320 22 to to IN cord-019043-cqmqwl3i 320 23 reduction reduction NN cord-019043-cqmqwl3i 320 24 in in IN cord-019043-cqmqwl3i 320 25 glomerular glomerular JJ cord-019043-cqmqwl3i 320 26 blood blood NN cord-019043-cqmqwl3i 320 27 flow flow NN cord-019043-cqmqwl3i 320 28 , , , cord-019043-cqmqwl3i 320 29 which which WDT cord-019043-cqmqwl3i 320 30 has have VBZ cord-019043-cqmqwl3i 320 31 beneficial beneficial JJ cord-019043-cqmqwl3i 320 32 effects effect NNS cord-019043-cqmqwl3i 320 33 for for IN cord-019043-cqmqwl3i 320 34 kidney kidney NN cord-019043-cqmqwl3i 320 35 survival survival NN cord-019043-cqmqwl3i 320 36 in in IN cord-019043-cqmqwl3i 320 37 chronic chronic JJ cord-019043-cqmqwl3i 320 38 kidney kidney NN cord-019043-cqmqwl3i 320 39 disease disease NN cord-019043-cqmqwl3i 320 40 patients patient NNS cord-019043-cqmqwl3i 320 41 but but CC cord-019043-cqmqwl3i 320 42 may may MD cord-019043-cqmqwl3i 320 43 lead lead VB cord-019043-cqmqwl3i 320 44 to to IN cord-019043-cqmqwl3i 320 45 worsening worsen VBG cord-019043-cqmqwl3i 320 46 kidney kidney NN cord-019043-cqmqwl3i 320 47 function function NN cord-019043-cqmqwl3i 320 48 in in IN cord-019043-cqmqwl3i 320 49 patients patient NNS cord-019043-cqmqwl3i 320 50 with with IN cord-019043-cqmqwl3i 320 51 AKI AKI NNP cord-019043-cqmqwl3i 320 52 peritoneal peritoneal JJ cord-019043-cqmqwl3i 320 53 dialysis dialysis NN cord-019043-cqmqwl3i 320 54 compared compare VBN cord-019043-cqmqwl3i 320 55 with with IN cord-019043-cqmqwl3i 320 56 those those DT cord-019043-cqmqwl3i 320 57 treated treat VBN cord-019043-cqmqwl3i 320 58 with with IN cord-019043-cqmqwl3i 320 59 hemodialysis hemodialysis NN cord-019043-cqmqwl3i 320 60 . . . cord-019043-cqmqwl3i 321 1 Determination determination NN cord-019043-cqmqwl3i 321 2 of of IN cord-019043-cqmqwl3i 321 3 the the DT cord-019043-cqmqwl3i 321 4 optimal optimal JJ cord-019043-cqmqwl3i 321 5 dose dose NN cord-019043-cqmqwl3i 321 6 intensity intensity NN cord-019043-cqmqwl3i 321 7 for for IN cord-019043-cqmqwl3i 321 8 small small JJ cord-019043-cqmqwl3i 321 9 solute solute NN cord-019043-cqmqwl3i 321 10 clearance clearance NN cord-019043-cqmqwl3i 321 11 for for IN cord-019043-cqmqwl3i 321 12 critically critically RB cord-019043-cqmqwl3i 321 13 ill ill JJ cord-019043-cqmqwl3i 321 14 patients patient NNS cord-019043-cqmqwl3i 321 15 with with IN cord-019043-cqmqwl3i 321 16 AKI AKI NNP cord-019043-cqmqwl3i 321 17 has have VBZ cord-019043-cqmqwl3i 321 18 long long RB cord-019043-cqmqwl3i 321 19 been be VBN cord-019043-cqmqwl3i 321 20 a a DT cord-019043-cqmqwl3i 321 21 clinical clinical JJ cord-019043-cqmqwl3i 321 22 priority priority NN cord-019043-cqmqwl3i 321 23 . . . cord-019043-cqmqwl3i 322 1 Early early JJ cord-019043-cqmqwl3i 322 2 randomized randomized JJ cord-019043-cqmqwl3i 322 3 trials trial NNS cord-019043-cqmqwl3i 322 4 clearly clearly RB cord-019043-cqmqwl3i 322 5 favored favor VBD cord-019043-cqmqwl3i 322 6 a a DT cord-019043-cqmqwl3i 322 7 more more RBR cord-019043-cqmqwl3i 322 8 intensive intensive JJ cord-019043-cqmqwl3i 322 9 strategy strategy NN cord-019043-cqmqwl3i 322 10 ; ; : cord-019043-cqmqwl3i 322 11 however however RB cord-019043-cqmqwl3i 322 12 , , , cord-019043-cqmqwl3i 322 13 recent recent JJ cord-019043-cqmqwl3i 322 14 high high JJ cord-019043-cqmqwl3i 322 15 - - HYPH cord-019043-cqmqwl3i 322 16 quality quality NN cord-019043-cqmqwl3i 322 17 data datum NNS cord-019043-cqmqwl3i 322 18 have have VBP cord-019043-cqmqwl3i 322 19 not not RB cord-019043-cqmqwl3i 322 20 shown show VBN cord-019043-cqmqwl3i 322 21 a a DT cord-019043-cqmqwl3i 322 22 benefit benefit NN cord-019043-cqmqwl3i 322 23 with with IN cord-019043-cqmqwl3i 322 24 this this DT cord-019043-cqmqwl3i 322 25 approach approach NN cord-019043-cqmqwl3i 322 26 . . . cord-019043-cqmqwl3i 323 1 Two two CD cord-019043-cqmqwl3i 323 2 multicenter multicenter JJ cord-019043-cqmqwl3i 323 3 randomized randomized JJ cord-019043-cqmqwl3i 323 4 trials trial NNS cord-019043-cqmqwl3i 323 5 , , , cord-019043-cqmqwl3i 323 6 the the DT cord-019043-cqmqwl3i 323 7 Department Department NNP cord-019043-cqmqwl3i 323 8 of of IN cord-019043-cqmqwl3i 323 9 Veterans Veterans NNP cord-019043-cqmqwl3i 323 10 Affairs Affairs NNP cord-019043-cqmqwl3i 323 11 / / SYM cord-019043-cqmqwl3i 323 12 National National NNP cord-019043-cqmqwl3i 323 13 Institutes Institutes NNPS cord-019043-cqmqwl3i 323 14 of of IN cord-019043-cqmqwl3i 323 15 Health Health NNP cord-019043-cqmqwl3i 323 16 ( ( -LRB- cord-019043-cqmqwl3i 323 17 VA VA NNP cord-019043-cqmqwl3i 323 18 / / SYM cord-019043-cqmqwl3i 323 19 NIH NIH NNP cord-019043-cqmqwl3i 323 20 ) ) -RRB- cord-019043-cqmqwl3i 324 1 Acute acute JJ cord-019043-cqmqwl3i 324 2 Renal Renal NNP cord-019043-cqmqwl3i 324 3 Failure Failure NNP cord-019043-cqmqwl3i 324 4 Trial Trial NNP cord-019043-cqmqwl3i 324 5 Network Network NNP cord-019043-cqmqwl3i 324 6 ( ( -LRB- cord-019043-cqmqwl3i 324 7 ATN ATN NNP cord-019043-cqmqwl3i 324 8 ) ) -RRB- cord-019043-cqmqwl3i 324 9 Study Study NNP cord-019043-cqmqwl3i 324 10 and and CC cord-019043-cqmqwl3i 324 11 the the DT cord-019043-cqmqwl3i 324 12 Randomized Randomized NNP cord-019043-cqmqwl3i 324 13 Evaluation Evaluation NNP cord-019043-cqmqwl3i 324 14 of of IN cord-019043-cqmqwl3i 324 15 Normal normal JJ cord-019043-cqmqwl3i 324 16 versus versus IN cord-019043-cqmqwl3i 324 17 Augmented augment VBN cord-019043-cqmqwl3i 324 18 Level level NN cord-019043-cqmqwl3i 324 19 ( ( -LRB- cord-019043-cqmqwl3i 324 20 RENAL RENAL NNP cord-019043-cqmqwl3i 324 21 ) ) -RRB- cord-019043-cqmqwl3i 324 22 Replacement replacement NN cord-019043-cqmqwl3i 324 23 Therapy Therapy NNP cord-019043-cqmqwl3i 324 24 Study Study NNP cord-019043-cqmqwl3i 324 25 , , , cord-019043-cqmqwl3i 324 26 found find VBD cord-019043-cqmqwl3i 324 27 no no DT cord-019043-cqmqwl3i 324 28 incremental incremental JJ cord-019043-cqmqwl3i 324 29 benefit benefit NN cord-019043-cqmqwl3i 324 30 in in IN cord-019043-cqmqwl3i 324 31 critically critically RB cord-019043-cqmqwl3i 324 32 ill ill JJ cord-019043-cqmqwl3i 324 33 patients patient NNS cord-019043-cqmqwl3i 324 34 with with IN cord-019043-cqmqwl3i 324 35 AKI AKI NNP cord-019043-cqmqwl3i 324 36 from from IN cord-019043-cqmqwl3i 324 37 a a DT cord-019043-cqmqwl3i 324 38 more more RBR cord-019043-cqmqwl3i 324 39 intensive intensive JJ cord-019043-cqmqwl3i 324 40 ( ( -LRB- cord-019043-cqmqwl3i 324 41 high high JJ cord-019043-cqmqwl3i 324 42 - - HYPH cord-019043-cqmqwl3i 324 43 dose dose NN cord-019043-cqmqwl3i 324 44 ) ) -RRB- cord-019043-cqmqwl3i 324 45 RRT rrt NN cord-019043-cqmqwl3i 324 46 compared compare VBN cord-019043-cqmqwl3i 324 47 with with IN cord-019043-cqmqwl3i 324 48 a a DT cord-019043-cqmqwl3i 324 49 less less RBR cord-019043-cqmqwl3i 324 50 intensive intensive JJ cord-019043-cqmqwl3i 324 51 RRT rrt NN cord-019043-cqmqwl3i 324 52 strategy strategy NN cord-019043-cqmqwl3i 324 53 [ [ -LRB- cord-019043-cqmqwl3i 324 54 22 22 CD cord-019043-cqmqwl3i 324 55 , , , cord-019043-cqmqwl3i 324 56 23 23 CD cord-019043-cqmqwl3i 324 57 ] ] -RRB- cord-019043-cqmqwl3i 324 58 . . . cord-019043-cqmqwl3i 325 1 The the DT cord-019043-cqmqwl3i 325 2 more more RBR cord-019043-cqmqwl3i 325 3 intensive intensive JJ cord-019043-cqmqwl3i 325 4 strategy strategy NN cord-019043-cqmqwl3i 325 5 did do VBD cord-019043-cqmqwl3i 325 6 not not RB cord-019043-cqmqwl3i 325 7 decrease decrease VB cord-019043-cqmqwl3i 325 8 mortality mortality NN cord-019043-cqmqwl3i 325 9 , , , cord-019043-cqmqwl3i 325 10 accelerate accelerate VB cord-019043-cqmqwl3i 325 11 recovery recovery NN cord-019043-cqmqwl3i 325 12 of of IN cord-019043-cqmqwl3i 325 13 kidney kidney NN cord-019043-cqmqwl3i 325 14 function function NN cord-019043-cqmqwl3i 325 15 , , , cord-019043-cqmqwl3i 325 16 or or CC cord-019043-cqmqwl3i 325 17 alter alter VB cord-019043-cqmqwl3i 325 18 the the DT cord-019043-cqmqwl3i 325 19 rate rate NN cord-019043-cqmqwl3i 325 20 of of IN cord-019043-cqmqwl3i 325 21 nonrenal nonrenal JJ cord-019043-cqmqwl3i 325 22 organ organ NN cord-019043-cqmqwl3i 325 23 failure failure NN cord-019043-cqmqwl3i 325 24 . . . cord-019043-cqmqwl3i 326 1 Importantly importantly RB cord-019043-cqmqwl3i 326 2 , , , cord-019043-cqmqwl3i 326 3 these these DT cord-019043-cqmqwl3i 326 4 findings finding NNS cord-019043-cqmqwl3i 326 5 do do VBP cord-019043-cqmqwl3i 326 6 not not RB cord-019043-cqmqwl3i 326 7 imply imply VB cord-019043-cqmqwl3i 326 8 that that IN cord-019043-cqmqwl3i 326 9 the the DT cord-019043-cqmqwl3i 326 10 dose dose NN cord-019043-cqmqwl3i 326 11 of of IN cord-019043-cqmqwl3i 326 12 RRT RRT NNP cord-019043-cqmqwl3i 326 13 is be VBZ cord-019043-cqmqwl3i 326 14 not not RB cord-019043-cqmqwl3i 326 15 important important JJ cord-019043-cqmqwl3i 326 16 , , , cord-019043-cqmqwl3i 326 17 but but CC cord-019043-cqmqwl3i 326 18 rather rather RB cord-019043-cqmqwl3i 326 19 , , , cord-019043-cqmqwl3i 326 20 the the DT cord-019043-cqmqwl3i 326 21 evidence evidence NN cord-019043-cqmqwl3i 326 22 would would MD cord-019043-cqmqwl3i 326 23 These these DT cord-019043-cqmqwl3i 326 24 indications indication NNS cord-019043-cqmqwl3i 326 25 in in IN cord-019043-cqmqwl3i 326 26 critical critical JJ cord-019043-cqmqwl3i 326 27 illness illness NN cord-019043-cqmqwl3i 326 28 may may MD cord-019043-cqmqwl3i 326 29 occur occur VB cord-019043-cqmqwl3i 326 30 separately separately RB cord-019043-cqmqwl3i 326 31 from from IN cord-019043-cqmqwl3i 326 32 patients patient NNS cord-019043-cqmqwl3i 326 33 with with IN cord-019043-cqmqwl3i 326 34 either either DT cord-019043-cqmqwl3i 326 35 life life NN cord-019043-cqmqwl3i 326 36 - - HYPH cord-019043-cqmqwl3i 326 37 threatening threaten VBG cord-019043-cqmqwl3i 326 38 complications complication NNS cord-019043-cqmqwl3i 326 39 of of IN cord-019043-cqmqwl3i 326 40 AKI AKI NNP cord-019043-cqmqwl3i 326 41 or or CC cord-019043-cqmqwl3i 326 42 advanced advanced JJ cord-019043-cqmqwl3i 326 43 AKI AKI NNP cord-019043-cqmqwl3i 326 44 and and CC cord-019043-cqmqwl3i 326 45 rather rather RB cord-019043-cqmqwl3i 326 46 can can MD cord-019043-cqmqwl3i 326 47 be be VB cord-019043-cqmqwl3i 326 48 viewed view VBN cord-019043-cqmqwl3i 326 49 as as IN cord-019043-cqmqwl3i 326 50 a a DT cord-019043-cqmqwl3i 326 51 platform platform NN cord-019043-cqmqwl3i 326 52 for for IN cord-019043-cqmqwl3i 326 53 organ organ NN cord-019043-cqmqwl3i 326 54 support support NN cord-019043-cqmqwl3i 326 55 to to TO cord-019043-cqmqwl3i 326 56 prevent prevent VB cord-019043-cqmqwl3i 326 57 complications complication NNS cord-019043-cqmqwl3i 326 58 and and CC cord-019043-cqmqwl3i 326 59 facilitate facilitate VB cord-019043-cqmqwl3i 326 60 treatment treatment NN cord-019043-cqmqwl3i 326 61 Volume volume NN cord-019043-cqmqwl3i 326 62 homeostasis homeostasis NN cord-019043-cqmqwl3i 326 63 Fluid Fluid NNP cord-019043-cqmqwl3i 326 64 accumulation accumulation NN cord-019043-cqmqwl3i 326 65 is be VBZ cord-019043-cqmqwl3i 326 66 worse bad JJR cord-019043-cqmqwl3i 326 67 in in IN cord-019043-cqmqwl3i 326 68 AKI AKI NNP cord-019043-cqmqwl3i 326 69 and and CC cord-019043-cqmqwl3i 326 70 is be VBZ cord-019043-cqmqwl3i 326 71 associated associate VBN cord-019043-cqmqwl3i 326 72 with with IN cord-019043-cqmqwl3i 326 73 worse bad JJR cord-019043-cqmqwl3i 326 74 outcome outcome NN cord-019043-cqmqwl3i 326 75 . . . cord-019043-cqmqwl3i 327 1 RRT RRT NNP cord-019043-cqmqwl3i 327 2 may may MD cord-019043-cqmqwl3i 327 3 represent represent VB cord-019043-cqmqwl3i 327 4 part part NN cord-019043-cqmqwl3i 327 5 of of IN cord-019043-cqmqwl3i 327 6 a a DT cord-019043-cqmqwl3i 327 7 strategy strategy NN cord-019043-cqmqwl3i 327 8 to to TO cord-019043-cqmqwl3i 327 9 mitigate mitigate VB cord-019043-cqmqwl3i 327 10 excessive excessive JJ cord-019043-cqmqwl3i 327 11 fluid fluid JJ cord-019043-cqmqwl3i 327 12 accumulation accumulation NN cord-019043-cqmqwl3i 327 13 Nutritional nutritional JJ cord-019043-cqmqwl3i 327 14 support support NN cord-019043-cqmqwl3i 327 15 RRT RRT NNP cord-019043-cqmqwl3i 327 16 can can MD cord-019043-cqmqwl3i 327 17 better well RBR cord-019043-cqmqwl3i 327 18 enable enable VB cord-019043-cqmqwl3i 327 19 the the DT cord-019043-cqmqwl3i 327 20 delivery delivery NN cord-019043-cqmqwl3i 327 21 of of IN cord-019043-cqmqwl3i 327 22 full full JJ cord-019043-cqmqwl3i 327 23 nutritional nutritional JJ cord-019043-cqmqwl3i 327 24 support support NN cord-019043-cqmqwl3i 327 25 ( ( -LRB- cord-019043-cqmqwl3i 327 26 i.e. i.e. FW cord-019043-cqmqwl3i 327 27 , , , cord-019043-cqmqwl3i 327 28 enteral enteral NN cord-019043-cqmqwl3i 327 29 or or CC cord-019043-cqmqwl3i 327 30 parenteral parenteral JJ cord-019043-cqmqwl3i 327 31 ) ) -RRB- cord-019043-cqmqwl3i 327 32 without without IN cord-019043-cqmqwl3i 327 33 the the DT cord-019043-cqmqwl3i 327 34 concern concern NN cord-019043-cqmqwl3i 327 35 for for IN cord-019043-cqmqwl3i 327 36 excessive excessive JJ cord-019043-cqmqwl3i 327 37 fluid fluid JJ cord-019043-cqmqwl3i 327 38 accumulation accumulation NN cord-019043-cqmqwl3i 328 1 Acid acid NN cord-019043-cqmqwl3i 328 2 - - HYPH cord-019043-cqmqwl3i 328 3 base base NN cord-019043-cqmqwl3i 328 4 / / SYM cord-019043-cqmqwl3i 328 5 electrolyte electrolyte NN cord-019043-cqmqwl3i 328 6 homeostasis homeostasis NN cord-019043-cqmqwl3i 328 7 RRT RRT NNP cord-019043-cqmqwl3i 328 8 may may MD cord-019043-cqmqwl3i 328 9 represent represent VB cord-019043-cqmqwl3i 328 10 part part NN cord-019043-cqmqwl3i 328 11 of of IN cord-019043-cqmqwl3i 328 12 a a DT cord-019043-cqmqwl3i 328 13 strategy strategy NN cord-019043-cqmqwl3i 328 14 to to TO cord-019043-cqmqwl3i 328 15 enable enable VB cord-019043-cqmqwl3i 328 16 " " `` cord-019043-cqmqwl3i 328 17 permissive permissive JJ cord-019043-cqmqwl3i 328 18 hypercapnia hypercapnia NN cord-019043-cqmqwl3i 328 19 " " '' cord-019043-cqmqwl3i 328 20 in in IN cord-019043-cqmqwl3i 328 21 ICU ICU NNP cord-019043-cqmqwl3i 328 22 patients patient NNS cord-019043-cqmqwl3i 328 23 with with IN cord-019043-cqmqwl3i 328 24 severe severe JJ cord-019043-cqmqwl3i 328 25 ARDS ARDS NNP cord-019043-cqmqwl3i 328 26 and and CC cord-019043-cqmqwl3i 328 27 AKI AKI NNP cord-019043-cqmqwl3i 328 28 / / SYM cord-019043-cqmqwl3i 328 29 CKD CKD NNP cord-019043-cqmqwl3i 328 30 or or CC cord-019043-cqmqwl3i 328 31 mitigate mitigate VB cord-019043-cqmqwl3i 328 32 adverse adverse JJ cord-019043-cqmqwl3i 328 33 effects effect NNS cord-019043-cqmqwl3i 328 34 from from IN cord-019043-cqmqwl3i 328 35 anticipated anticipate VBN cord-019043-cqmqwl3i 328 36 electrolyte electrolyte JJ cord-019043-cqmqwl3i 328 37 disorders disorder NNS cord-019043-cqmqwl3i 328 38 ( ( -LRB- cord-019043-cqmqwl3i 328 39 i.e. i.e. FW cord-019043-cqmqwl3i 328 40 , , , cord-019043-cqmqwl3i 328 41 tumor tumor NN cord-019043-cqmqwl3i 328 42 lysis lysis NN cord-019043-cqmqwl3i 328 43 syndrome syndrome NN cord-019043-cqmqwl3i 328 44 ) ) -RRB- cord-019043-cqmqwl3i 329 1 Immunomodulation Immunomodulation NNP cord-019043-cqmqwl3i 329 2 RRT RRT NNP cord-019043-cqmqwl3i 329 3 may may MD cord-019043-cqmqwl3i 329 4 represent represent VB cord-019043-cqmqwl3i 329 5 a a DT cord-019043-cqmqwl3i 329 6 strategy strategy NN cord-019043-cqmqwl3i 329 7 for for IN cord-019043-cqmqwl3i 329 8 modulating modulate VBG cord-019043-cqmqwl3i 329 9 and and CC cord-019043-cqmqwl3i 329 10 restoring restore VBG cord-019043-cqmqwl3i 329 11 immune immune JJ cord-019043-cqmqwl3i 329 12 function function NN cord-019043-cqmqwl3i 329 13 in in IN cord-019043-cqmqwl3i 329 14 sepsis sepsis NN cord-019043-cqmqwl3i 329 15 and and CC cord-019043-cqmqwl3i 329 16 associated associate VBD cord-019043-cqmqwl3i 329 17 severe severe JJ cord-019043-cqmqwl3i 329 18 inflammatory inflammatory JJ cord-019043-cqmqwl3i 329 19 states state NNS cord-019043-cqmqwl3i 329 20 . . . cord-019043-cqmqwl3i 330 1 Studies study NNS cord-019043-cqmqwl3i 330 2 are be VBP cord-019043-cqmqwl3i 330 3 ongoing ongoing JJ cord-019043-cqmqwl3i 330 4 Drug Drug NNP cord-019043-cqmqwl3i 330 5 delivery delivery NN cord-019043-cqmqwl3i 330 6 RRT rrt NN cord-019043-cqmqwl3i 330 7 can can MD cord-019043-cqmqwl3i 330 8 better well RBR cord-019043-cqmqwl3i 330 9 enable enable VB cord-019043-cqmqwl3i 330 10 the the DT cord-019043-cqmqwl3i 330 11 delivery delivery NN cord-019043-cqmqwl3i 330 12 of of IN cord-019043-cqmqwl3i 330 13 essential essential JJ cord-019043-cqmqwl3i 330 14 drugs drug NNS cord-019043-cqmqwl3i 330 15 ( ( -LRB- cord-019043-cqmqwl3i 330 16 i.e. i.e. FW cord-019043-cqmqwl3i 330 17 , , , cord-019043-cqmqwl3i 330 18 antimicrobials antimicrobial NNS cord-019043-cqmqwl3i 330 19 ) ) -RRB- cord-019043-cqmqwl3i 330 20 without without IN cord-019043-cqmqwl3i 330 21 the the DT cord-019043-cqmqwl3i 330 22 concern concern NN cord-019043-cqmqwl3i 330 23 for for IN cord-019043-cqmqwl3i 330 24 excessive excessive JJ cord-019043-cqmqwl3i 330 25 fluid fluid JJ cord-019043-cqmqwl3i 330 26 accumulation accumulation NN cord-019043-cqmqwl3i 331 1 In in IN cord-019043-cqmqwl3i 331 2 general general JJ cord-019043-cqmqwl3i 331 3 , , , cord-019043-cqmqwl3i 331 4 RRT rrt PRP cord-019043-cqmqwl3i 331 5 should should MD cord-019043-cqmqwl3i 331 6 be be VB cord-019043-cqmqwl3i 331 7 discontinued discontinue VBN cord-019043-cqmqwl3i 331 8 when when WRB cord-019043-cqmqwl3i 331 9 it -PRON- PRP cord-019043-cqmqwl3i 331 10 is be VBZ cord-019043-cqmqwl3i 331 11 no no RB cord-019043-cqmqwl3i 331 12 longer long RBR cord-019043-cqmqwl3i 331 13 indicated indicate VBN cord-019043-cqmqwl3i 331 14 due due IN cord-019043-cqmqwl3i 331 15 to to IN cord-019043-cqmqwl3i 331 16 either either CC cord-019043-cqmqwl3i 331 17 sufficient sufficient JJ cord-019043-cqmqwl3i 331 18 residual residual JJ cord-019043-cqmqwl3i 331 19 or or CC cord-019043-cqmqwl3i 331 20 recovering recover VBG cord-019043-cqmqwl3i 331 21 kidney kidney NN cord-019043-cqmqwl3i 331 22 function function NN cord-019043-cqmqwl3i 331 23 or or CC cord-019043-cqmqwl3i 331 24 a a DT cord-019043-cqmqwl3i 331 25 change change NN cord-019043-cqmqwl3i 331 26 in in IN cord-019043-cqmqwl3i 331 27 the the DT cord-019043-cqmqwl3i 331 28 overall overall JJ cord-019043-cqmqwl3i 331 29 goals goal NNS cord-019043-cqmqwl3i 331 30 of of IN cord-019043-cqmqwl3i 331 31 care care NN cord-019043-cqmqwl3i 331 32 of of IN cord-019043-cqmqwl3i 331 33 the the DT cord-019043-cqmqwl3i 331 34 patient patient NN cord-019043-cqmqwl3i 331 35 . . . cord-019043-cqmqwl3i 332 1 The the DT cord-019043-cqmqwl3i 332 2 best good JJS cord-019043-cqmqwl3i 332 3 predictor predictor NN cord-019043-cqmqwl3i 332 4 for for IN cord-019043-cqmqwl3i 332 5 successful successful JJ cord-019043-cqmqwl3i 332 6 weaning weaning NN cord-019043-cqmqwl3i 332 7 from from IN cord-019043-cqmqwl3i 332 8 RRT RRT NNP cord-019043-cqmqwl3i 332 9 for for IN cord-019043-cqmqwl3i 332 10 critically critically RB cord-019043-cqmqwl3i 332 11 ill ill JJ cord-019043-cqmqwl3i 332 12 patients patient NNS cord-019043-cqmqwl3i 332 13 is be VBZ cord-019043-cqmqwl3i 332 14 the the DT cord-019043-cqmqwl3i 332 15 volume volume NN cord-019043-cqmqwl3i 332 16 of of IN cord-019043-cqmqwl3i 332 17 spontaneous spontaneous JJ cord-019043-cqmqwl3i 332 18 urine urine NN cord-019043-cqmqwl3i 332 19 production production NN cord-019043-cqmqwl3i 332 20 in in IN cord-019043-cqmqwl3i 332 21 24 24 CD cord-019043-cqmqwl3i 332 22 h. h. NN cord-019043-cqmqwl3i 332 23 Those those DT cord-019043-cqmqwl3i 332 24 capable capable JJ cord-019043-cqmqwl3i 332 25 of of IN cord-019043-cqmqwl3i 332 26 producing produce VBG cord-019043-cqmqwl3i 332 27 ≥450 ≥450 ADD cord-019043-cqmqwl3i 332 28 - - HYPH cord-019043-cqmqwl3i 332 29 500 500 CD cord-019043-cqmqwl3i 332 30 mL ml NN cord-019043-cqmqwl3i 332 31 urine urine NN cord-019043-cqmqwl3i 332 32 per per IN cord-019043-cqmqwl3i 332 33 day day NN cord-019043-cqmqwl3i 332 34 have have VB cord-019043-cqmqwl3i 332 35 a a DT cord-019043-cqmqwl3i 332 36 higher high JJR cord-019043-cqmqwl3i 332 37 likelihood likelihood NN cord-019043-cqmqwl3i 332 38 of of IN cord-019043-cqmqwl3i 332 39 short short JJ cord-019043-cqmqwl3i 332 40 - - HYPH cord-019043-cqmqwl3i 332 41 term term NN cord-019043-cqmqwl3i 332 42 recovery recovery NN cord-019043-cqmqwl3i 332 43 and and CC cord-019043-cqmqwl3i 332 44 dialysis dialysis NN cord-019043-cqmqwl3i 332 45 independence independence NN cord-019043-cqmqwl3i 332 46 . . . cord-019043-cqmqwl3i 333 1 There there EX cord-019043-cqmqwl3i 333 2 is be VBZ cord-019043-cqmqwl3i 333 3 no no DT cord-019043-cqmqwl3i 333 4 evidence evidence NN cord-019043-cqmqwl3i 333 5 to to TO cord-019043-cqmqwl3i 333 6 suggest suggest VB cord-019043-cqmqwl3i 333 7 improved improve VBN cord-019043-cqmqwl3i 333 8 or or CC cord-019043-cqmqwl3i 333 9 accelerated accelerate VBN cord-019043-cqmqwl3i 333 10 recovery recovery NN cord-019043-cqmqwl3i 333 11 and and CC cord-019043-cqmqwl3i 333 12 dialysis dialysis NN cord-019043-cqmqwl3i 333 13 independence independence NN cord-019043-cqmqwl3i 333 14 with with IN cord-019043-cqmqwl3i 333 15 early early JJ cord-019043-cqmqwl3i 333 16 forced force VBN cord-019043-cqmqwl3i 333 17 diuresis diuresis NN cord-019043-cqmqwl3i 333 18 with with IN cord-019043-cqmqwl3i 333 19 furosemide furosemide NN cord-019043-cqmqwl3i 333 20 . . . cord-019043-cqmqwl3i 334 1 Drug drug NN cord-019043-cqmqwl3i 334 2 pharmacokinetics pharmacokinetic NNS cord-019043-cqmqwl3i 334 3 in in IN cord-019043-cqmqwl3i 334 4 critical critical JJ cord-019043-cqmqwl3i 334 5 illness illness NN cord-019043-cqmqwl3i 334 6 and and CC cord-019043-cqmqwl3i 334 7 AKI AKI NNP cord-019043-cqmqwl3i 334 8 is be VBZ cord-019043-cqmqwl3i 334 9 significantly significantly RB cord-019043-cqmqwl3i 334 10 modified modify VBN cord-019043-cqmqwl3i 334 11 due due IN cord-019043-cqmqwl3i 334 12 to to IN cord-019043-cqmqwl3i 334 13 alterations alteration NNS cord-019043-cqmqwl3i 334 14 in in IN cord-019043-cqmqwl3i 334 15 drug drug NN cord-019043-cqmqwl3i 334 16 bioavailability bioavailability NN cord-019043-cqmqwl3i 334 17 , , , cord-019043-cqmqwl3i 334 18 reduced reduced JJ cord-019043-cqmqwl3i 334 19 protein protein NN cord-019043-cqmqwl3i 334 20 binding binding NN cord-019043-cqmqwl3i 334 21 , , , cord-019043-cqmqwl3i 334 22 increased increase VBN cord-019043-cqmqwl3i 334 23 volume volume NN cord-019043-cqmqwl3i 334 24 of of IN cord-019043-cqmqwl3i 334 25 distribution distribution NN cord-019043-cqmqwl3i 334 26 , , , cord-019043-cqmqwl3i 334 27 altered alter VBN cord-019043-cqmqwl3i 334 28 biotransformation biotransformation NN cord-019043-cqmqwl3i 334 29 , , , cord-019043-cqmqwl3i 334 30 and and CC cord-019043-cqmqwl3i 334 31 reduced reduce VBN cord-019043-cqmqwl3i 334 32 intrinsic intrinsic JJ cord-019043-cqmqwl3i 334 33 clearance clearance NN cord-019043-cqmqwl3i 334 34 and and CC cord-019043-cqmqwl3i 334 35 elimination elimination NN cord-019043-cqmqwl3i 334 36 . . . cord-019043-cqmqwl3i 335 1 Appropriate appropriate JJ cord-019043-cqmqwl3i 335 2 drug drug NN cord-019043-cqmqwl3i 335 3 dosing dosing NN cord-019043-cqmqwl3i 335 4 is be VBZ cord-019043-cqmqwl3i 335 5 further far RBR cord-019043-cqmqwl3i 335 6 complicated complicate VBN cord-019043-cqmqwl3i 335 7 by by IN cord-019043-cqmqwl3i 335 8 a a DT cord-019043-cqmqwl3i 335 9 number number NN cord-019043-cqmqwl3i 335 10 of of IN cord-019043-cqmqwl3i 335 11 factors factor NNS cord-019043-cqmqwl3i 335 12 , , , cord-019043-cqmqwl3i 335 13 including include VBG cord-019043-cqmqwl3i 335 14 baseline baseline JJ cord-019043-cqmqwl3i 335 15 comorbid comorbid NN cord-019043-cqmqwl3i 335 16 disease disease NN cord-019043-cqmqwl3i 335 17 of of IN cord-019043-cqmqwl3i 335 18 patients patient NNS cord-019043-cqmqwl3i 335 19 ( ( -LRB- cord-019043-cqmqwl3i 335 20 i.e. i.e. FW cord-019043-cqmqwl3i 335 21 , , , cord-019043-cqmqwl3i 335 22 CKD CKD NNP cord-019043-cqmqwl3i 335 23 ) ) -RRB- cord-019043-cqmqwl3i 335 24 , , , cord-019043-cqmqwl3i 335 25 need need VBP cord-019043-cqmqwl3i 335 26 for for IN cord-019043-cqmqwl3i 335 27 multiple multiple JJ cord-019043-cqmqwl3i 335 28 drugs drug NNS cord-019043-cqmqwl3i 335 29 that that WDT cord-019043-cqmqwl3i 335 30 potentially potentially RB cord-019043-cqmqwl3i 335 31 interact interact VBP cord-019043-cqmqwl3i 335 32 with with IN cord-019043-cqmqwl3i 335 33 vital vital JJ cord-019043-cqmqwl3i 335 34 functions function NNS cord-019043-cqmqwl3i 335 35 , , , cord-019043-cqmqwl3i 335 36 lower lower VB cord-019043-cqmqwl3i 335 37 thresholds threshold NNS cord-019043-cqmqwl3i 335 38 for for IN cord-019043-cqmqwl3i 335 39 toxicity toxicity NN cord-019043-cqmqwl3i 335 40 , , , cord-019043-cqmqwl3i 335 41 evolving evolve VBG cord-019043-cqmqwl3i 335 42 illness illness NN cord-019043-cqmqwl3i 335 43 severity severity NN cord-019043-cqmqwl3i 335 44 and and CC cord-019043-cqmqwl3i 335 45 organ organ NN cord-019043-cqmqwl3i 335 46 dysfunction dysfunction NN cord-019043-cqmqwl3i 335 47 ( ( -LRB- cord-019043-cqmqwl3i 335 48 i.e. i.e. FW cord-019043-cqmqwl3i 335 49 , , , cord-019043-cqmqwl3i 335 50 changes change NNS cord-019043-cqmqwl3i 335 51 in in IN cord-019043-cqmqwl3i 335 52 GFR GFR NNP cord-019043-cqmqwl3i 335 53 ) ) -RRB- cord-019043-cqmqwl3i 335 54 , , , cord-019043-cqmqwl3i 335 55 and and CC cord-019043-cqmqwl3i 335 56 superimposed superimpose VBD cord-019043-cqmqwl3i 335 57 extracorporeal extracorporeal JJ cord-019043-cqmqwl3i 335 58 drug drug NN cord-019043-cqmqwl3i 335 59 removal removal NN cord-019043-cqmqwl3i 335 60 ( ( -LRB- cord-019043-cqmqwl3i 335 61 Table Table NNP cord-019043-cqmqwl3i 335 62 32 32 CD cord-019043-cqmqwl3i 335 63 .10 .10 CD cord-019043-cqmqwl3i 335 64 ) ) -RRB- cord-019043-cqmqwl3i 335 65 . . . cord-019043-cqmqwl3i 336 1 In in IN cord-019043-cqmqwl3i 336 2 general general JJ cord-019043-cqmqwl3i 336 3 , , , cord-019043-cqmqwl3i 336 4 there there EX cord-019043-cqmqwl3i 336 5 are be VBP cord-019043-cqmqwl3i 336 6 several several JJ cord-019043-cqmqwl3i 336 7 pragmatic pragmatic JJ cord-019043-cqmqwl3i 336 8 steps step NNS cord-019043-cqmqwl3i 336 9 to to TO cord-019043-cqmqwl3i 336 10 help help VB cord-019043-cqmqwl3i 336 11 guide guide VB cord-019043-cqmqwl3i 336 12 drug drug NN cord-019043-cqmqwl3i 336 13 dosing dose VBG cord-019043-cqmqwl3i 336 14 in in IN cord-019043-cqmqwl3i 336 15 critically critically RB cord-019043-cqmqwl3i 336 16 ill ill JJ cord-019043-cqmqwl3i 336 17 patients patient NNS cord-019043-cqmqwl3i 336 18 with with IN cord-019043-cqmqwl3i 336 19 AKI AKI NNP cord-019043-cqmqwl3i 336 20 and and CC cord-019043-cqmqwl3i 336 21 those those DT cord-019043-cqmqwl3i 336 22 receiving receive VBG cord-019043-cqmqwl3i 336 23 RRT RRT NNP cord-019043-cqmqwl3i 336 24 [ [ -LRB- cord-019043-cqmqwl3i 336 25 24 24 CD cord-019043-cqmqwl3i 336 26 ] ] -RRB- cord-019043-cqmqwl3i 336 27 . . . cord-019043-cqmqwl3i 337 1 First first RB cord-019043-cqmqwl3i 337 2 , , , cord-019043-cqmqwl3i 337 3 the the DT cord-019043-cqmqwl3i 337 4 literature literature NN cord-019043-cqmqwl3i 337 5 should should MD cord-019043-cqmqwl3i 337 6 be be VB cord-019043-cqmqwl3i 337 7 reviewed review VBN cord-019043-cqmqwl3i 337 8 for for IN cord-019043-cqmqwl3i 337 9 existing exist VBG cord-019043-cqmqwl3i 337 10 data datum NNS cord-019043-cqmqwl3i 337 11 on on IN cord-019043-cqmqwl3i 337 12 drug drug NN cord-019043-cqmqwl3i 337 13 dose dose NN cord-019043-cqmqwl3i 337 14 guidance guidance NN cord-019043-cqmqwl3i 337 15 for for IN cord-019043-cqmqwl3i 337 16 a a DT cord-019043-cqmqwl3i 337 17 specific specific JJ cord-019043-cqmqwl3i 337 18 drug drug NN cord-019043-cqmqwl3i 337 19 [ [ -LRB- cord-019043-cqmqwl3i 337 20 25 25 CD cord-019043-cqmqwl3i 337 21 ] ] -RRB- cord-019043-cqmqwl3i 337 22 . . . cord-019043-cqmqwl3i 338 1 Second second RB cord-019043-cqmqwl3i 338 2 , , , cord-019043-cqmqwl3i 338 3 for for IN cord-019043-cqmqwl3i 338 4 drugs drug NNS cord-019043-cqmqwl3i 338 5 with with IN cord-019043-cqmqwl3i 338 6 primary primary JJ cord-019043-cqmqwl3i 338 7 renal renal JJ cord-019043-cqmqwl3i 338 8 elimination elimination NN cord-019043-cqmqwl3i 338 9 , , , cord-019043-cqmqwl3i 338 10 a a DT cord-019043-cqmqwl3i 338 11 bedside bedside NN cord-019043-cqmqwl3i 338 12 estimate estimate NN cord-019043-cqmqwl3i 338 13 of of IN cord-019043-cqmqwl3i 338 14 baseline baseline JJ cord-019043-cqmqwl3i 338 15 GFR GFR NNP cord-019043-cqmqwl3i 338 16 and and CC cord-019043-cqmqwl3i 338 17 a a DT cord-019043-cqmqwl3i 338 18 dynamic dynamic JJ cord-019043-cqmqwl3i 338 19 assessment assessment NN cord-019043-cqmqwl3i 338 20 of of IN cord-019043-cqmqwl3i 338 21 total total JJ cord-019043-cqmqwl3i 338 22 creatinine creatinine NN cord-019043-cqmqwl3i 338 23 clearance clearance NN cord-019043-cqmqwl3i 338 24 , , , cord-019043-cqmqwl3i 338 25 if if IN cord-019043-cqmqwl3i 338 26 applicable applicable JJ cord-019043-cqmqwl3i 338 27 , , , cord-019043-cqmqwl3i 338 28 should should MD cord-019043-cqmqwl3i 338 29 be be VB cord-019043-cqmqwl3i 338 30 undertaken undertake VBN cord-019043-cqmqwl3i 338 31 , , , cord-019043-cqmqwl3i 338 32 assuming assume VBG cord-019043-cqmqwl3i 338 33 there there EX cord-019043-cqmqwl3i 338 34 is be VBZ cord-019043-cqmqwl3i 338 35 no no DT cord-019043-cqmqwl3i 338 36 significant significant JJ cord-019043-cqmqwl3i 338 37 secretion secretion NN cord-019043-cqmqwl3i 338 38 or or CC cord-019043-cqmqwl3i 338 39 reabsorption reabsorption NN cord-019043-cqmqwl3i 338 40 . . . cord-019043-cqmqwl3i 339 1 In in IN cord-019043-cqmqwl3i 339 2 particular particular JJ cord-019043-cqmqwl3i 339 3 , , , cord-019043-cqmqwl3i 339 4 consideration consideration NN cord-019043-cqmqwl3i 339 5 should should MD cord-019043-cqmqwl3i 339 6 be be VB cord-019043-cqmqwl3i 339 7 given give VBN cord-019043-cqmqwl3i 339 8 to to IN cord-019043-cqmqwl3i 339 9 patients patient NNS cord-019043-cqmqwl3i 339 10 receiving receive VBG cord-019043-cqmqwl3i 339 11 RRT rrt PRP cord-019043-cqmqwl3i 339 12 who who WP cord-019043-cqmqwl3i 339 13 have have VBP cord-019043-cqmqwl3i 339 14 recovering recover VBG cord-019043-cqmqwl3i 339 15 or or CC cord-019043-cqmqwl3i 339 16 residual residual JJ cord-019043-cqmqwl3i 339 17 renal renal JJ cord-019043-cqmqwl3i 339 18 function function NN cord-019043-cqmqwl3i 339 19 . . . cord-019043-cqmqwl3i 340 1 Third third RB cord-019043-cqmqwl3i 340 2 , , , cord-019043-cqmqwl3i 340 3 particularly particularly RB cord-019043-cqmqwl3i 340 4 for for IN cord-019043-cqmqwl3i 340 5 drugs drug NNS cord-019043-cqmqwl3i 340 6 with with IN cord-019043-cqmqwl3i 340 7 a a DT cord-019043-cqmqwl3i 340 8 narrow narrow JJ cord-019043-cqmqwl3i 340 9 therapeutic therapeutic JJ cord-019043-cqmqwl3i 340 10 index index NN cord-019043-cqmqwl3i 340 11 and and CC cord-019043-cqmqwl3i 340 12 risk risk NN cord-019043-cqmqwl3i 340 13 of of IN cord-019043-cqmqwl3i 340 14 toxicity toxicity NN cord-019043-cqmqwl3i 340 15 , , , cord-019043-cqmqwl3i 340 16 therapeutic therapeutic JJ cord-019043-cqmqwl3i 340 17 drug drug NN cord-019043-cqmqwl3i 340 18 monitoring monitoring NN cord-019043-cqmqwl3i 340 19 when when WRB cord-019043-cqmqwl3i 340 20 possible possible JJ cord-019043-cqmqwl3i 340 21 should should MD cord-019043-cqmqwl3i 340 22 be be VB cord-019043-cqmqwl3i 340 23 undertaken undertake VBN cord-019043-cqmqwl3i 340 24 ( ( -LRB- cord-019043-cqmqwl3i 340 25 i.e. i.e. FW cord-019043-cqmqwl3i 340 26 , , , cord-019043-cqmqwl3i 340 27 phenytoin phenytoin NN cord-019043-cqmqwl3i 340 28 , , , cord-019043-cqmqwl3i 340 29 vancomycin vancomycin NNS cord-019043-cqmqwl3i 340 30 , , , cord-019043-cqmqwl3i 340 31 aminoglycosides aminoglycoside NNS cord-019043-cqmqwl3i 340 32 ) ) -RRB- cord-019043-cqmqwl3i 340 33 . . . cord-019043-cqmqwl3i 341 1 Fourth fourth RB cord-019043-cqmqwl3i 341 2 , , , cord-019043-cqmqwl3i 341 3 several several JJ cord-019043-cqmqwl3i 341 4 drug drug NN cord-019043-cqmqwl3i 341 5 classes class NNS cord-019043-cqmqwl3i 341 6 may may MD cord-019043-cqmqwl3i 341 7 be be VB cord-019043-cqmqwl3i 341 8 administered administer VBN cord-019043-cqmqwl3i 341 9 based base VBN cord-019043-cqmqwl3i 341 10 on on IN cord-019043-cqmqwl3i 341 11 their -PRON- PRP$ cord-019043-cqmqwl3i 341 12 observed observed JJ cord-019043-cqmqwl3i 341 13 clinical clinical JJ cord-019043-cqmqwl3i 341 14 response response NN cord-019043-cqmqwl3i 341 15 , , , cord-019043-cqmqwl3i 341 16 such such JJ cord-019043-cqmqwl3i 341 17 as as IN cord-019043-cqmqwl3i 341 18 with with IN cord-019043-cqmqwl3i 341 19 sedatives sedative NNS cord-019043-cqmqwl3i 341 20 , , , cord-019043-cqmqwl3i 341 21 analgesics analgesic NNS cord-019043-cqmqwl3i 341 22 , , , cord-019043-cqmqwl3i 341 23 or or CC cord-019043-cqmqwl3i 341 24 vasoactive vasoactive JJ cord-019043-cqmqwl3i 341 25 medications medication NNS cord-019043-cqmqwl3i 341 26 . . . cord-019043-cqmqwl3i 342 1 However however RB cord-019043-cqmqwl3i 342 2 , , , cord-019043-cqmqwl3i 342 3 selected select VBN cord-019043-cqmqwl3i 342 4 drugs drug NNS cord-019043-cqmqwl3i 342 5 have have VBP cord-019043-cqmqwl3i 342 6 potentially potentially RB cord-019043-cqmqwl3i 342 7 toxic toxic JJ cord-019043-cqmqwl3i 342 8 metabolites metabolite NNS cord-019043-cqmqwl3i 342 9 that that WDT cord-019043-cqmqwl3i 342 10 can can MD cord-019043-cqmqwl3i 342 11 accumulate accumulate VB cord-019043-cqmqwl3i 342 12 in in IN cord-019043-cqmqwl3i 342 13 patients patient NNS cord-019043-cqmqwl3i 342 14 with with IN cord-019043-cqmqwl3i 342 15 reduced reduce VBN cord-019043-cqmqwl3i 342 16 kidney kidney NN cord-019043-cqmqwl3i 342 17 function function NN cord-019043-cqmqwl3i 342 18 . . . cord-019043-cqmqwl3i 343 1 As as IN cord-019043-cqmqwl3i 343 2 examples example NNS cord-019043-cqmqwl3i 343 3 , , , cord-019043-cqmqwl3i 343 4 the the DT cord-019043-cqmqwl3i 343 5 elimination elimination NN cord-019043-cqmqwl3i 343 6 of of IN cord-019043-cqmqwl3i 343 7 α1-hydroxymidazolam α1-hydroxymidazolam JJ cord-019043-cqmqwl3i 343 8 ( ( -LRB- cord-019043-cqmqwl3i 343 9 main main JJ cord-019043-cqmqwl3i 343 10 metabolite metabolite NN cord-019043-cqmqwl3i 343 11 of of IN cord-019043-cqmqwl3i 343 12 midazolam midazolam NNP cord-019043-cqmqwl3i 343 13 ) ) -RRB- cord-019043-cqmqwl3i 343 14 and and CC cord-019043-cqmqwl3i 343 15 glucuronide glucuronide JJ cord-019043-cqmqwl3i 343 16 metabolites metabolite NNS cord-019043-cqmqwl3i 343 17 of of IN cord-019043-cqmqwl3i 343 18 morphine morphine NN cord-019043-cqmqwl3i 343 19 are be VBP cord-019043-cqmqwl3i 343 20 principally principally RB cord-019043-cqmqwl3i 343 21 eliminated eliminate VBN cord-019043-cqmqwl3i 343 22 by by IN cord-019043-cqmqwl3i 343 23 the the DT cord-019043-cqmqwl3i 343 24 kidneys kidney NNS cord-019043-cqmqwl3i 343 25 and and CC cord-019043-cqmqwl3i 343 26 thus thus RB cord-019043-cqmqwl3i 343 27 may may MD cord-019043-cqmqwl3i 343 28 accumulate accumulate VB cord-019043-cqmqwl3i 343 29 in in IN cord-019043-cqmqwl3i 343 30 AKI AKI NNP cord-019043-cqmqwl3i 343 31 / / SYM cord-019043-cqmqwl3i 343 32 CKD CKD NNP cord-019043-cqmqwl3i 343 33 . . . cord-019043-cqmqwl3i 344 1 Finally finally RB cord-019043-cqmqwl3i 344 2 , , , cord-019043-cqmqwl3i 344 3 given give VBN cord-019043-cqmqwl3i 344 4 the the DT cord-019043-cqmqwl3i 344 5 complexity complexity NN cord-019043-cqmqwl3i 344 6 , , , cord-019043-cqmqwl3i 344 7 there there EX cord-019043-cqmqwl3i 344 8 is be VBZ cord-019043-cqmqwl3i 344 9 a a DT cord-019043-cqmqwl3i 344 10 recognized recognize VBN cord-019043-cqmqwl3i 344 11 need need NN cord-019043-cqmqwl3i 344 12 for for IN cord-019043-cqmqwl3i 344 13 a a DT cord-019043-cqmqwl3i 344 14 dedicated dedicated JJ cord-019043-cqmqwl3i 344 15 ICU ICU NNP cord-019043-cqmqwl3i 344 16 pharmacist pharmacist NN cord-019043-cqmqwl3i 344 17 among among IN cord-019043-cqmqwl3i 344 18 the the DT cord-019043-cqmqwl3i 344 19 interdisciplinary interdisciplinary JJ cord-019043-cqmqwl3i 344 20 ICU ICU NNP cord-019043-cqmqwl3i 344 21 team team NN cord-019043-cqmqwl3i 344 22 , , , cord-019043-cqmqwl3i 344 23 particularly particularly RB cord-019043-cqmqwl3i 344 24 for for IN cord-019043-cqmqwl3i 344 25 patients patient NNS cord-019043-cqmqwl3i 344 26 with with IN cord-019043-cqmqwl3i 344 27 CKD CKD NNP cord-019043-cqmqwl3i 344 28 or or CC cord-019043-cqmqwl3i 344 29 AKI AKI NNP cord-019043-cqmqwl3i 344 30 . . . cord-019043-cqmqwl3i 345 1 The the DT cord-019043-cqmqwl3i 345 2 prevalence prevalence NN cord-019043-cqmqwl3i 345 3 of of IN cord-019043-cqmqwl3i 345 4 CKD CKD NNP cord-019043-cqmqwl3i 345 5 and and CC cord-019043-cqmqwl3i 345 6 ESRD ESRD NNP cord-019043-cqmqwl3i 345 7 is be VBZ cord-019043-cqmqwl3i 345 8 increasing increase VBG cord-019043-cqmqwl3i 345 9 . . . cord-019043-cqmqwl3i 346 1 These these DT cord-019043-cqmqwl3i 346 2 patients patient NNS cord-019043-cqmqwl3i 346 3 are be VBP cord-019043-cqmqwl3i 346 4 burdened burden VBN cord-019043-cqmqwl3i 346 5 by by IN cord-019043-cqmqwl3i 346 6 high high JJ cord-019043-cqmqwl3i 346 7 comorbid comorbid NN cord-019043-cqmqwl3i 346 8 disease disease NN cord-019043-cqmqwl3i 346 9 , , , cord-019043-cqmqwl3i 346 10 are be VBP cord-019043-cqmqwl3i 346 11 more more RBR cord-019043-cqmqwl3i 346 12 likely likely JJ cord-019043-cqmqwl3i 346 13 to to TO cord-019043-cqmqwl3i 346 14 interact interact VB cord-019043-cqmqwl3i 346 15 with with IN cord-019043-cqmqwl3i 346 16 critical critical JJ cord-019043-cqmqwl3i 346 17 care care NN cord-019043-cqmqwl3i 346 18 services service NNS cord-019043-cqmqwl3i 346 19 , , , cord-019043-cqmqwl3i 346 20 and and CC cord-019043-cqmqwl3i 346 21 have have VBP cord-019043-cqmqwl3i 346 22 worse bad JJR cord-019043-cqmqwl3i 346 23 short short JJ cord-019043-cqmqwl3i 346 24 - - HYPH cord-019043-cqmqwl3i 346 25 term term NN cord-019043-cqmqwl3i 346 26 and and CC cord-019043-cqmqwl3i 346 27 long long JJ cord-019043-cqmqwl3i 346 28 - - HYPH cord-019043-cqmqwl3i 346 29 term term NN cord-019043-cqmqwl3i 346 30 outcomes outcome NNS cord-019043-cqmqwl3i 346 31 compared compare VBN cord-019043-cqmqwl3i 346 32 with with IN cord-019043-cqmqwl3i 346 33 non non JJ cord-019043-cqmqwl3i 346 34 - - JJ cord-019043-cqmqwl3i 346 35 CKD ckd JJ cord-019043-cqmqwl3i 346 36 patients patient NNS cord-019043-cqmqwl3i 346 37 . . . cord-019043-cqmqwl3i 347 1 Short short JJ cord-019043-cqmqwl3i 347 2 - - HYPH cord-019043-cqmqwl3i 347 3 term term NN cord-019043-cqmqwl3i 347 4 mortality mortality NN cord-019043-cqmqwl3i 347 5 is be VBZ cord-019043-cqmqwl3i 347 6 predominantly predominantly RB cord-019043-cqmqwl3i 347 7 driven drive VBN cord-019043-cqmqwl3i 347 8 by by IN cord-019043-cqmqwl3i 347 9 acuity acuity NN cord-019043-cqmqwl3i 347 10 of of IN cord-019043-cqmqwl3i 347 11 illness illness NN cord-019043-cqmqwl3i 347 12 rather rather RB cord-019043-cqmqwl3i 347 13 than than IN cord-019043-cqmqwl3i 347 14 CKD CKD NNP cord-019043-cqmqwl3i 347 15 status status NN cord-019043-cqmqwl3i 347 16 per per FW cord-019043-cqmqwl3i 347 17 se se FW cord-019043-cqmqwl3i 347 18 , , , cord-019043-cqmqwl3i 347 19 and and CC cord-019043-cqmqwl3i 347 20 CKD CKD NNP cord-019043-cqmqwl3i 347 21 status status NN cord-019043-cqmqwl3i 347 22 should should MD cord-019043-cqmqwl3i 347 23 likely likely RB cord-019043-cqmqwl3i 347 24 not not RB cord-019043-cqmqwl3i 347 25 preclude preclude VB cord-019043-cqmqwl3i 347 26 critical critical JJ cord-019043-cqmqwl3i 347 27 care care NN cord-019043-cqmqwl3i 347 28 support support NN cord-019043-cqmqwl3i 347 29 . . . cord-019043-cqmqwl3i 348 1 The the DT cord-019043-cqmqwl3i 348 2 pathophysiologic pathophysiologic NN cord-019043-cqmqwl3i 348 3 changes change NNS cord-019043-cqmqwl3i 348 4 associated associate VBN cord-019043-cqmqwl3i 348 5 with with IN cord-019043-cqmqwl3i 348 6 CKD CKD NNP cord-019043-cqmqwl3i 348 7 / / SYM cord-019043-cqmqwl3i 348 8 ESKD ESKD NNP cord-019043-cqmqwl3i 348 9 and and CC cord-019043-cqmqwl3i 348 10 development development NN cord-019043-cqmqwl3i 348 11 of of IN cord-019043-cqmqwl3i 348 12 superimposed superimpose VBN cord-019043-cqmqwl3i 348 13 AKI AKI NNP cord-019043-cqmqwl3i 348 14 can can MD cord-019043-cqmqwl3i 348 15 present present VB cord-019043-cqmqwl3i 348 16 unique unique JJ cord-019043-cqmqwl3i 348 17 challenges challenge NNS cord-019043-cqmqwl3i 348 18 for for IN cord-019043-cqmqwl3i 348 19 clinicians clinician NNS cord-019043-cqmqwl3i 348 20 in in IN cord-019043-cqmqwl3i 348 21 the the DT cord-019043-cqmqwl3i 348 22 ICU ICU NNP cord-019043-cqmqwl3i 348 23 management management NN cord-019043-cqmqwl3i 348 24 of of IN cord-019043-cqmqwl3i 348 25 these these DT cord-019043-cqmqwl3i 348 26 patients patient NNS cord-019043-cqmqwl3i 348 27 . . . cord-019043-cqmqwl3i 349 1 Only only JJ cord-019043-cqmqwl3i 349 2 drug drug NN cord-019043-cqmqwl3i 349 3 within within IN cord-019043-cqmqwl3i 349 4 intravascular intravascular JJ cord-019043-cqmqwl3i 349 5 compartment compartment NN cord-019043-cqmqwl3i 349 6 available available JJ cord-019043-cqmqwl3i 349 7 for for IN cord-019043-cqmqwl3i 349 8 EC EC NNP cord-019043-cqmqwl3i 349 9 clearance clearance NN cord-019043-cqmqwl3i 349 10 Extracorporeal extracorporeal NN cord-019043-cqmqwl3i 349 11 therapy therapy NN cord-019043-cqmqwl3i 349 12 Dose dose NN cord-019043-cqmqwl3i 349 13 intensity intensity NN cord-019043-cqmqwl3i 349 14 Higher higher RBR cord-019043-cqmqwl3i 349 15 dose dose NN cord-019043-cqmqwl3i 349 16 intensity intensity NN cord-019043-cqmqwl3i 349 17 , , , cord-019043-cqmqwl3i 349 18 such such JJ cord-019043-cqmqwl3i 349 19 as as IN cord-019043-cqmqwl3i 349 20 prescription prescription NN cord-019043-cqmqwl3i 349 21 of of IN cord-019043-cqmqwl3i 349 22 HVHF HVHF NNP cord-019043-cqmqwl3i 349 23 , , , cord-019043-cqmqwl3i 349 24 will will MD cord-019043-cqmqwl3i 349 25 increase increase VB cord-019043-cqmqwl3i 349 26 EC EC NNP cord-019043-cqmqwl3i 349 27 clearance clearance NN cord-019043-cqmqwl3i 349 28 ; ; : cord-019043-cqmqwl3i 349 29 clearance clearance NN cord-019043-cqmqwl3i 349 30 impacted impact VBD cord-019043-cqmqwl3i 349 31 if if IN cord-019043-cqmqwl3i 349 32 large large JJ cord-019043-cqmqwl3i 349 33 discrepancy discrepancy NN cord-019043-cqmqwl3i 349 34 between between IN cord-019043-cqmqwl3i 349 35 prescribed prescribe VBN cord-019043-cqmqwl3i 349 36 and and CC cord-019043-cqmqwl3i 349 37 delivered deliver VBD cord-019043-cqmqwl3i 349 38 dose dose NN cord-019043-cqmqwl3i 349 39 BFR BFR NNP cord-019043-cqmqwl3i 349 40 Higher high JJR cord-019043-cqmqwl3i 349 41 blood blood NN cord-019043-cqmqwl3i 349 42 flow flow NN cord-019043-cqmqwl3i 349 43 rate rate NN cord-019043-cqmqwl3i 349 44 will will MD cord-019043-cqmqwl3i 349 45 deliver deliver VB cord-019043-cqmqwl3i 349 46 more more JJR cord-019043-cqmqwl3i 349 47 drug drug NN cord-019043-cqmqwl3i 349 48 to to TO cord-019043-cqmqwl3i 349 49 filter filter VB cord-019043-cqmqwl3i 349 50 , , , cord-019043-cqmqwl3i 349 51 only only RB cord-019043-cqmqwl3i 349 52 important important JJ cord-019043-cqmqwl3i 349 53 at at IN cord-019043-cqmqwl3i 349 54 either either CC cord-019043-cqmqwl3i 349 55 very very RB cord-019043-cqmqwl3i 349 56 low low JJ cord-019043-cqmqwl3i 349 57 or or CC cord-019043-cqmqwl3i 349 58 high high JJ cord-019043-cqmqwl3i 349 59 blood blood NN cord-019043-cqmqwl3i 349 60 flow flow NN cord-019043-cqmqwl3i 349 61 or or CC cord-019043-cqmqwl3i 349 62 large large JJ cord-019043-cqmqwl3i 349 63 discrepancy discrepancy NN cord-019043-cqmqwl3i 349 64 between between IN cord-019043-cqmqwl3i 349 65 prescribed prescribe VBN cord-019043-cqmqwl3i 349 66 and and CC cord-019043-cqmqwl3i 349 67 delivered deliver VBN cord-019043-cqmqwl3i 349 68 dose dose NN cord-019043-cqmqwl3i 349 69 Mode mode NN cord-019043-cqmqwl3i 349 70 ( ( -LRB- cord-019043-cqmqwl3i 349 71 convention convention NN cord-019043-cqmqwl3i 349 72 vs. vs. IN cord-019043-cqmqwl3i 349 73 dialysis dialysis NN cord-019043-cqmqwl3i 349 74 ) ) -RRB- cord-019043-cqmqwl3i 350 1 EC EC NNP cord-019043-cqmqwl3i 350 2 clearance clearance NN cord-019043-cqmqwl3i 350 3 dependent dependent JJ cord-019043-cqmqwl3i 350 4 on on IN cord-019043-cqmqwl3i 350 5 total total JJ cord-019043-cqmqwl3i 350 6 effluent effluent NN cord-019043-cqmqwl3i 350 7 flow flow NN cord-019043-cqmqwl3i 350 8 rate rate NN cord-019043-cqmqwl3i 350 9 and/or and/or CC cord-019043-cqmqwl3i 350 10 dialysate dialysate NN cord-019043-cqmqwl3i 350 11 flow flow NN cord-019043-cqmqwl3i 350 12 rate rate NN cord-019043-cqmqwl3i 350 13 Replacement replacement NN cord-019043-cqmqwl3i 350 14 fluid fluid NN cord-019043-cqmqwl3i 350 15 Prefilter Prefilter NNP cord-019043-cqmqwl3i 350 16 replacement replacement NN cord-019043-cqmqwl3i 350 17 fluid fluid JJ cord-019043-cqmqwl3i 350 18 administration administration NN cord-019043-cqmqwl3i 350 19 will will MD cord-019043-cqmqwl3i 350 20 result result VB cord-019043-cqmqwl3i 350 21 in in IN cord-019043-cqmqwl3i 350 22 hemodilution hemodilution NN cord-019043-cqmqwl3i 350 23 and and CC cord-019043-cqmqwl3i 350 24 lower low JJR cord-019043-cqmqwl3i 350 25 EC EC NNP cord-019043-cqmqwl3i 350 26 clearance clearance NN cord-019043-cqmqwl3i 350 27 Filter filter NN cord-019043-cqmqwl3i 350 28 membrane membrane NN cord-019043-cqmqwl3i 350 29 Sieving Sieving NNP cord-019043-cqmqwl3i 350 30 / / SYM cord-019043-cqmqwl3i 350 31 diffusion diffusion NN cord-019043-cqmqwl3i 350 32 coefficient coefficient NN cord-019043-cqmqwl3i 350 33 important important JJ cord-019043-cqmqwl3i 350 34 , , , cord-019043-cqmqwl3i 350 35 whereas whereas IN cord-019043-cqmqwl3i 350 36 surface surface NN cord-019043-cqmqwl3i 350 37 area area NN cord-019043-cqmqwl3i 350 38 has have VBZ cord-019043-cqmqwl3i 350 39 limited limit VBN cord-019043-cqmqwl3i 350 40 impact impact NN cord-019043-cqmqwl3i 350 41 on on IN cord-019043-cqmqwl3i 350 42 EC EC NNP cord-019043-cqmqwl3i 350 43 clearance clearance NN cord-019043-cqmqwl3i 350 44 Organ Organ NNP cord-019043-cqmqwl3i 350 45 recovery recovery NN cord-019043-cqmqwl3i 350 46 Residual residual NN cord-019043-cqmqwl3i 350 47 or or CC cord-019043-cqmqwl3i 350 48 recovery recovery NN cord-019043-cqmqwl3i 350 49 kidney kidney NN cord-019043-cqmqwl3i 350 50 function function NN cord-019043-cqmqwl3i 350 51 can can MD cord-019043-cqmqwl3i 350 52 greatly greatly RB cord-019043-cqmqwl3i 350 53 increase increase VB cord-019043-cqmqwl3i 350 54 overall overall JJ cord-019043-cqmqwl3i 350 55 clearance clearance NN cord-019043-cqmqwl3i 350 56 during during IN cord-019043-cqmqwl3i 350 57 extracorporeal extracorporeal JJ cord-019043-cqmqwl3i 350 58 therapy therapy NN cord-019043-cqmqwl3i 350 59 Before before IN cord-019043-cqmqwl3i 350 60 You -PRON- PRP cord-019043-cqmqwl3i 350 61 Finish finish VBP cord-019043-cqmqwl3i 350 62 : : : cord-019043-cqmqwl3i 351 1 Practice practice VB cord-019043-cqmqwl3i 351 2 Pearls pearl NNS cord-019043-cqmqwl3i 351 3 for for IN cord-019043-cqmqwl3i 351 4 the the DT cord-019043-cqmqwl3i 351 5 Clinician clinician NN cord-019043-cqmqwl3i 352 1 • • NNP cord-019043-cqmqwl3i 352 2 CKD CKD NNP cord-019043-cqmqwl3i 352 3 and and CC cord-019043-cqmqwl3i 352 4 specially specially RB cord-019043-cqmqwl3i 352 5 ESRD ESRD NNP cord-019043-cqmqwl3i 352 6 status status NN cord-019043-cqmqwl3i 352 7 alone alone RB cord-019043-cqmqwl3i 352 8 should should MD cord-019043-cqmqwl3i 352 9 not not RB cord-019043-cqmqwl3i 352 10 exclude exclude VB cord-019043-cqmqwl3i 352 11 consideration consideration NN cord-019043-cqmqwl3i 352 12 for for IN cord-019043-cqmqwl3i 352 13 admission admission NN cord-019043-cqmqwl3i 352 14 in in IN cord-019043-cqmqwl3i 352 15 the the DT cord-019043-cqmqwl3i 352 16 ICU ICU NNP cord-019043-cqmqwl3i 352 17 . . . cord-019043-cqmqwl3i 353 1 • • NNP cord-019043-cqmqwl3i 354 1 Prognostic prognostic JJ cord-019043-cqmqwl3i 354 2 score score NN cord-019043-cqmqwl3i 354 3 results result NNS cord-019043-cqmqwl3i 354 4 should should MD cord-019043-cqmqwl3i 354 5 be be VB cord-019043-cqmqwl3i 354 6 carefully carefully RB cord-019043-cqmqwl3i 354 7 considered consider VBN cord-019043-cqmqwl3i 354 8 since since IN cord-019043-cqmqwl3i 354 9 they -PRON- PRP cord-019043-cqmqwl3i 354 10 routinely routinely RB cord-019043-cqmqwl3i 354 11 overestimate overestimate VBP cord-019043-cqmqwl3i 354 12 mortality mortality NN cord-019043-cqmqwl3i 354 13 in in IN cord-019043-cqmqwl3i 354 14 ESRD ESRD NNP cord-019043-cqmqwl3i 354 15 patients patient NNS cord-019043-cqmqwl3i 354 16 . . . cord-019043-cqmqwl3i 355 1 • • NNP cord-019043-cqmqwl3i 356 1 The the DT cord-019043-cqmqwl3i 356 2 principles principle NNS cord-019043-cqmqwl3i 356 3 of of IN cord-019043-cqmqwl3i 356 4 management management NN cord-019043-cqmqwl3i 356 5 of of IN cord-019043-cqmqwl3i 356 6 sepsis sepsis NN cord-019043-cqmqwl3i 356 7 should should MD cord-019043-cqmqwl3i 356 8 be be VB cord-019043-cqmqwl3i 356 9 applied apply VBN cord-019043-cqmqwl3i 356 10 to to IN cord-019043-cqmqwl3i 356 11 CKD CKD NNP cord-019043-cqmqwl3i 356 12 , , , cord-019043-cqmqwl3i 356 13 fluid fluid JJ cord-019043-cqmqwl3i 356 14 overload overload NN cord-019043-cqmqwl3i 356 15 being be VBG cord-019043-cqmqwl3i 356 16 an an DT cord-019043-cqmqwl3i 356 17 obvious obvious JJ cord-019043-cqmqwl3i 356 18 caveat caveat NN cord-019043-cqmqwl3i 356 19 . . . cord-019043-cqmqwl3i 357 1 • • NNP cord-019043-cqmqwl3i 358 1 Fluid fluid JJ cord-019043-cqmqwl3i 358 2 therapy therapy NN cord-019043-cqmqwl3i 358 3 should should MD cord-019043-cqmqwl3i 358 4 be be VB cord-019043-cqmqwl3i 358 5 considered consider VBN cord-019043-cqmqwl3i 358 6 a a DT cord-019043-cqmqwl3i 358 7 drug drug NN cord-019043-cqmqwl3i 358 8 therapy therapy NN cord-019043-cqmqwl3i 358 9 and and CC cord-019043-cqmqwl3i 358 10 dosed dose VBD cord-019043-cqmqwl3i 358 11 accordingly accordingly RB cord-019043-cqmqwl3i 358 12 . . . cord-019043-cqmqwl3i 359 1 • • NNP cord-019043-cqmqwl3i 360 1 Long long JJ cord-019043-cqmqwl3i 360 2 - - HYPH cord-019043-cqmqwl3i 360 3 term term NN cord-019043-cqmqwl3i 360 4 kidney kidney NN cord-019043-cqmqwl3i 360 5 function function NN cord-019043-cqmqwl3i 360 6 monitoring monitoring NN cord-019043-cqmqwl3i 360 7 is be VBZ cord-019043-cqmqwl3i 360 8 mandatory mandatory JJ cord-019043-cqmqwl3i 360 9 after after IN cord-019043-cqmqwl3i 360 10 an an DT cord-019043-cqmqwl3i 360 11 AKI AKI NNP cord-019043-cqmqwl3i 360 12 episode episode NN cord-019043-cqmqwl3i 360 13 . . . cord-019043-cqmqwl3i 361 1 • • NNP cord-019043-cqmqwl3i 362 1 Consider consider VB cord-019043-cqmqwl3i 362 2 initiation initiation NN cord-019043-cqmqwl3i 362 3 of of IN cord-019043-cqmqwl3i 362 4 RRT RRT NNP cord-019043-cqmqwl3i 362 5 ahead ahead RB cord-019043-cqmqwl3i 362 6 of of IN cord-019043-cqmqwl3i 362 7 absolute absolute JJ cord-019043-cqmqwl3i 362 8 indications indication NNS cord-019043-cqmqwl3i 362 9 . . . cord-019043-cqmqwl3i 363 1 CRRT CRRT NNP cord-019043-cqmqwl3i 363 2 is be VBZ cord-019043-cqmqwl3i 363 3 the the DT cord-019043-cqmqwl3i 363 4 preferred preferred JJ cord-019043-cqmqwl3i 363 5 option option NN cord-019043-cqmqwl3i 363 6 for for IN cord-019043-cqmqwl3i 363 7 the the DT cord-019043-cqmqwl3i 363 8 hemodynamically hemodynamically RB cord-019043-cqmqwl3i 363 9 unstable unstable JJ cord-019043-cqmqwl3i 363 10 patient patient NN cord-019043-cqmqwl3i 363 11 . . . cord-019043-cqmqwl3i 364 1 • • NNP cord-019043-cqmqwl3i 365 1 Avoid avoid VB cord-019043-cqmqwl3i 365 2 nephrotoxic nephrotoxic JJ cord-019043-cqmqwl3i 365 3 drugs drug NNS cord-019043-cqmqwl3i 365 4 for for IN cord-019043-cqmqwl3i 365 5 patients patient NNS cord-019043-cqmqwl3i 365 6 with with IN cord-019043-cqmqwl3i 365 7 CKD CKD NNP cord-019043-cqmqwl3i 365 8 and/or and/or CC cord-019043-cqmqwl3i 365 9 at at IN cord-019043-cqmqwl3i 365 10 risk risk NN cord-019043-cqmqwl3i 365 11 for for IN cord-019043-cqmqwl3i 365 12 AKI AKI NNP cord-019043-cqmqwl3i 365 13 . . . cord-019043-cqmqwl3i 366 1 • • NNP cord-019043-cqmqwl3i 367 1 Adjust adjust VB cord-019043-cqmqwl3i 367 2 drug drug NN cord-019043-cqmqwl3i 367 3 regimens regimen NNS cord-019043-cqmqwl3i 367 4 to to IN cord-019043-cqmqwl3i 367 5 kidney kidney NN cord-019043-cqmqwl3i 367 6 function function NN cord-019043-cqmqwl3i 367 7 , , , cord-019043-cqmqwl3i 367 8 except except IN cord-019043-cqmqwl3i 367 9 for for IN cord-019043-cqmqwl3i 367 10 the the DT cord-019043-cqmqwl3i 367 11 loading loading NN cord-019043-cqmqwl3i 367 12 dose dose NN cord-019043-cqmqwl3i 367 13 of of IN cord-019043-cqmqwl3i 367 14 antibiotics antibiotic NNS cord-019043-cqmqwl3i 367 15 . . . cord-019043-cqmqwl3i 368 1 Chronic chronic JJ cord-019043-cqmqwl3i 368 2 kidney kidney NN cord-019043-cqmqwl3i 368 3 disease disease NN cord-019043-cqmqwl3i 368 4 : : : cord-019043-cqmqwl3i 368 5 Kidney Kidney NNP cord-019043-cqmqwl3i 368 6 Disease Disease NNP cord-019043-cqmqwl3i 368 7 : : : cord-019043-cqmqwl3i 369 1 Improving improve VBG cord-019043-cqmqwl3i 369 2 Global Global NNP cord-019043-cqmqwl3i 369 3 Outcomes Outcomes NNPS cord-019043-cqmqwl3i 369 4 ( ( -LRB- cord-019043-cqmqwl3i 369 5 KDIGO KDIGO NNP cord-019043-cqmqwl3i 369 6 ) ) -RRB- cord-019043-cqmqwl3i 369 7 Chronic chronic JJ cord-019043-cqmqwl3i 369 8 Kidney kidney NN cord-019043-cqmqwl3i 369 9 Disease Disease NNP cord-019043-cqmqwl3i 369 10 Working Working NNP cord-019043-cqmqwl3i 369 11 Group Group NNP cord-019043-cqmqwl3i 369 12 . . . cord-019043-cqmqwl3i 370 1 KDIGO KDIGO NNP cord-019043-cqmqwl3i 370 2 2012 2012 CD cord-019043-cqmqwl3i 370 3 Clinical clinical JJ cord-019043-cqmqwl3i 370 4 practice practice NN cord-019043-cqmqwl3i 370 5 guideline guideline NN cord-019043-cqmqwl3i 370 6 for for IN cord-019043-cqmqwl3i 370 7 the the DT cord-019043-cqmqwl3i 370 8 evaluation evaluation NN cord-019043-cqmqwl3i 370 9 and and CC cord-019043-cqmqwl3i 370 10 management management NN cord-019043-cqmqwl3i 370 11 of of IN cord-019043-cqmqwl3i 370 12 chronic chronic JJ cord-019043-cqmqwl3i 370 13 kidney kidney NN cord-019043-cqmqwl3i 370 14 disease disease NN cord-019043-cqmqwl3i 370 15 Surviving survive VBG cord-019043-cqmqwl3i 370 16 sepsis sepsis NN cord-019043-cqmqwl3i 370 17 campaign campaign NN cord-019043-cqmqwl3i 370 18 : : : cord-019043-cqmqwl3i 370 19 international international NNP cord-019043-cqmqwl3i 370 20 guidelines guideline NNS cord-019043-cqmqwl3i 370 21 for for IN cord-019043-cqmqwl3i 370 22 management management NN cord-019043-cqmqwl3i 370 23 of of IN cord-019043-cqmqwl3i 370 24 severe severe JJ cord-019043-cqmqwl3i 370 25 sepsis sepsis NN cord-019043-cqmqwl3i 370 26 and and CC cord-019043-cqmqwl3i 370 27 septic septic JJ cord-019043-cqmqwl3i 370 28 shock shock NN cord-019043-cqmqwl3i 370 29 European European NNP cord-019043-cqmqwl3i 370 30 Society Society NNP cord-019043-cqmqwl3i 370 31 of of IN cord-019043-cqmqwl3i 370 32 Intensive Intensive NNP cord-019043-cqmqwl3i 370 33 Care Care NNP cord-019043-cqmqwl3i 370 34 Medicine Medicine NNP cord-019043-cqmqwl3i 370 35 . . . cord-019043-cqmqwl3i 371 1 Consensus consensus NN cord-019043-cqmqwl3i 371 2 statement statement NN cord-019043-cqmqwl3i 371 3 of of IN cord-019043-cqmqwl3i 371 4 the the DT cord-019043-cqmqwl3i 371 5 ESICM ESICM NNP cord-019043-cqmqwl3i 371 6 task task NN cord-019043-cqmqwl3i 371 7 force force NN cord-019043-cqmqwl3i 371 8 on on IN cord-019043-cqmqwl3i 371 9 colloid colloid NN cord-019043-cqmqwl3i 371 10 volume volume NN cord-019043-cqmqwl3i 371 11 therapy therapy NN cord-019043-cqmqwl3i 371 12 in in IN cord-019043-cqmqwl3i 371 13 critically critically RB cord-019043-cqmqwl3i 371 14 ill ill JJ cord-019043-cqmqwl3i 371 15 patients patient NNS cord-019043-cqmqwl3i 371 16 Nutritional nutritional JJ cord-019043-cqmqwl3i 371 17 support support NN cord-019043-cqmqwl3i 371 18 : : : cord-019043-cqmqwl3i 372 1 Critical Critical NNP cord-019043-cqmqwl3i 372 2 Care Care NNP cord-019043-cqmqwl3i 372 3 Nutrition Nutrition NNP cord-019043-cqmqwl3i 372 4 -Canadian -Canadian NNP cord-019043-cqmqwl3i 372 5 Clinical Clinical NNP cord-019043-cqmqwl3i 372 6 Practice Practice NNP cord-019043-cqmqwl3i 372 7 Guidelines Guidelines NNPS cord-019043-cqmqwl3i 372 8 Patients patient NNS cord-019043-cqmqwl3i 372 9 with with IN cord-019043-cqmqwl3i 372 10 end end NN cord-019043-cqmqwl3i 372 11 - - HYPH cord-019043-cqmqwl3i 372 12 stage stage NN cord-019043-cqmqwl3i 372 13 renal renal JJ cord-019043-cqmqwl3i 372 14 disease disease NN cord-019043-cqmqwl3i 372 15 admitted admit VBD cord-019043-cqmqwl3i 372 16 to to IN cord-019043-cqmqwl3i 372 17 the the DT cord-019043-cqmqwl3i 372 18 intensive intensive JJ cord-019043-cqmqwl3i 372 19 care care NN cord-019043-cqmqwl3i 372 20 unit unit NN cord-019043-cqmqwl3i 372 21 : : : cord-019043-cqmqwl3i 372 22 systematic systematic JJ cord-019043-cqmqwl3i 372 23 review review NN cord-019043-cqmqwl3i 373 1 Hemodynamic Hemodynamic NNP cord-019043-cqmqwl3i 373 2 monitoring monitoring NN cord-019043-cqmqwl3i 373 3 in in IN cord-019043-cqmqwl3i 373 4 the the DT cord-019043-cqmqwl3i 373 5 critically critically RB cord-019043-cqmqwl3i 373 6 ill ill JJ cord-019043-cqmqwl3i 373 7 : : : cord-019043-cqmqwl3i 374 1 spanning span VBG cord-019043-cqmqwl3i 374 2 the the DT cord-019043-cqmqwl3i 374 3 range range NN cord-019043-cqmqwl3i 374 4 of of IN cord-019043-cqmqwl3i 374 5 kidney kidney NN cord-019043-cqmqwl3i 374 6 function function NN cord-019043-cqmqwl3i 374 7 Mechanical mechanical JJ cord-019043-cqmqwl3i 374 8 ventilation ventilation NN cord-019043-cqmqwl3i 374 9 and and CC cord-019043-cqmqwl3i 374 10 the the DT cord-019043-cqmqwl3i 374 11 kidney kidney NN cord-019043-cqmqwl3i 374 12 Updates update NNS cord-019043-cqmqwl3i 374 13 in in IN cord-019043-cqmqwl3i 374 14 the the DT cord-019043-cqmqwl3i 374 15 management management NN cord-019043-cqmqwl3i 374 16 of of IN cord-019043-cqmqwl3i 374 17 acute acute JJ cord-019043-cqmqwl3i 374 18 lung lung NN cord-019043-cqmqwl3i 374 19 injury injury NN cord-019043-cqmqwl3i 374 20 : : : cord-019043-cqmqwl3i 374 21 a a DT cord-019043-cqmqwl3i 374 22 focus focus NN cord-019043-cqmqwl3i 374 23 on on IN cord-019043-cqmqwl3i 374 24 the the DT cord-019043-cqmqwl3i 374 25 overlap overlap NN cord-019043-cqmqwl3i 374 26 between between IN cord-019043-cqmqwl3i 374 27 AKI AKI NNP cord-019043-cqmqwl3i 374 28 and and CC cord-019043-cqmqwl3i 374 29 ARDS ARDS NNP cord-019043-cqmqwl3i 374 30 Fluid Fluid NNP cord-019043-cqmqwl3i 374 31 balance balance NN cord-019043-cqmqwl3i 374 32 and and CC cord-019043-cqmqwl3i 374 33 acute acute JJ cord-019043-cqmqwl3i 374 34 kidney kidney NN cord-019043-cqmqwl3i 374 35 injury injury NN cord-019043-cqmqwl3i 374 36 Chloride chloride NN cord-019043-cqmqwl3i 374 37 - - HYPH cord-019043-cqmqwl3i 374 38 restrictive restrictive JJ cord-019043-cqmqwl3i 374 39 fluid fluid JJ cord-019043-cqmqwl3i 374 40 administration administration NN cord-019043-cqmqwl3i 374 41 and and CC cord-019043-cqmqwl3i 374 42 incidence incidence NN cord-019043-cqmqwl3i 374 43 of of IN cord-019043-cqmqwl3i 374 44 acute acute JJ cord-019043-cqmqwl3i 374 45 kidney kidney NN cord-019043-cqmqwl3i 374 46 injury injury NN cord-019043-cqmqwl3i 374 47 - - HYPH cord-019043-cqmqwl3i 374 48 reply reply NN cord-019043-cqmqwl3i 374 49 Consensus Consensus NNP cord-019043-cqmqwl3i 374 50 statement statement NN cord-019043-cqmqwl3i 374 51 of of IN cord-019043-cqmqwl3i 374 52 the the DT cord-019043-cqmqwl3i 374 53 ESICM ESICM NNP cord-019043-cqmqwl3i 374 54 task task NN cord-019043-cqmqwl3i 374 55 force force NN cord-019043-cqmqwl3i 374 56 on on IN cord-019043-cqmqwl3i 374 57 colloid colloid NN cord-019043-cqmqwl3i 374 58 volume volume NN cord-019043-cqmqwl3i 374 59 therapy therapy NN cord-019043-cqmqwl3i 374 60 in in IN cord-019043-cqmqwl3i 374 61 critically critically RB cord-019043-cqmqwl3i 374 62 ill ill JJ cord-019043-cqmqwl3i 374 63 patients patient NNS cord-019043-cqmqwl3i 374 64 ESPEN ESPEN NNP cord-019043-cqmqwl3i 374 65 guidelines guideline NNS cord-019043-cqmqwl3i 374 66 on on IN cord-019043-cqmqwl3i 374 67 parenteral parenteral JJ cord-019043-cqmqwl3i 374 68 nutrition nutrition NN cord-019043-cqmqwl3i 374 69 : : : cord-019043-cqmqwl3i 374 70 adult adult NN cord-019043-cqmqwl3i 374 71 renal renal JJ cord-019043-cqmqwl3i 374 72 failure failure NN cord-019043-cqmqwl3i 375 1 Surviving survive VBG cord-019043-cqmqwl3i 375 2 sepsis sepsis NN cord-019043-cqmqwl3i 375 3 campaign campaign NN cord-019043-cqmqwl3i 375 4 : : : cord-019043-cqmqwl3i 376 1 international international NNP cord-019043-cqmqwl3i 376 2 guidelines guideline NNS cord-019043-cqmqwl3i 376 3 for for IN cord-019043-cqmqwl3i 376 4 management management NN cord-019043-cqmqwl3i 376 5 of of IN cord-019043-cqmqwl3i 376 6 severe severe JJ cord-019043-cqmqwl3i 376 7 sepsis sepsis NN cord-019043-cqmqwl3i 376 8 and and CC cord-019043-cqmqwl3i 376 9 septic septic JJ cord-019043-cqmqwl3i 376 10 shock shock NN cord-019043-cqmqwl3i 376 11 : : : cord-019043-cqmqwl3i 377 1 2012 2012 CD cord-019043-cqmqwl3i 377 2 Kidney Kidney NNP cord-019043-cqmqwl3i 377 3 Disease Disease NNP cord-019043-cqmqwl3i 377 4 : : : cord-019043-cqmqwl3i 377 5 Improving improve VBG cord-019043-cqmqwl3i 377 6 Global Global NNP cord-019043-cqmqwl3i 377 7 Outcomes Outcomes NNPS cord-019043-cqmqwl3i 377 8 ( ( -LRB- cord-019043-cqmqwl3i 377 9 KDIGO KDIGO NNP cord-019043-cqmqwl3i 377 10 ) ) -RRB- cord-019043-cqmqwl3i 377 11 Chronic chronic JJ cord-019043-cqmqwl3i 377 12 Kidney kidney NN cord-019043-cqmqwl3i 377 13 Disease Disease NNP cord-019043-cqmqwl3i 377 14 Work Work NNP cord-019043-cqmqwl3i 377 15 Group Group NNP cord-019043-cqmqwl3i 377 16 . . . cord-019043-cqmqwl3i 378 1 KDIGO KDIGO NNP cord-019043-cqmqwl3i 378 2 2012 2012 CD cord-019043-cqmqwl3i 378 3 clinical clinical JJ cord-019043-cqmqwl3i 378 4 practice practice NN cord-019043-cqmqwl3i 378 5 guideline guideline NN cord-019043-cqmqwl3i 378 6 for for IN cord-019043-cqmqwl3i 378 7 the the DT cord-019043-cqmqwl3i 378 8 evaluation evaluation NN cord-019043-cqmqwl3i 378 9 and and CC cord-019043-cqmqwl3i 378 10 management management NN cord-019043-cqmqwl3i 378 11 of of IN cord-019043-cqmqwl3i 378 12 chronic chronic JJ cord-019043-cqmqwl3i 378 13 kidney kidney NN cord-019043-cqmqwl3i 378 14 disease disease NN cord-019043-cqmqwl3i 378 15 Kidney Kidney NNP cord-019043-cqmqwl3i 378 16 Disease Disease NNP cord-019043-cqmqwl3i 378 17 : : : cord-019043-cqmqwl3i 378 18 Improving improve VBG cord-019043-cqmqwl3i 378 19 Global Global NNP cord-019043-cqmqwl3i 378 20 Outcomes Outcomes NNPS cord-019043-cqmqwl3i 378 21 ( ( -LRB- cord-019043-cqmqwl3i 378 22 KDIGO KDIGO NNP cord-019043-cqmqwl3i 378 23 ) ) -RRB- cord-019043-cqmqwl3i 379 1 Acute acute JJ cord-019043-cqmqwl3i 379 2 Kidney kidney NN cord-019043-cqmqwl3i 379 3 Injury injury NN cord-019043-cqmqwl3i 379 4 Work Work NNP cord-019043-cqmqwl3i 379 5 Group Group NNP cord-019043-cqmqwl3i 379 6 . . . cord-019043-cqmqwl3i 380 1 KDIGO KDIGO NNP cord-019043-cqmqwl3i 380 2 clinical clinical JJ cord-019043-cqmqwl3i 380 3 practice practice NN cord-019043-cqmqwl3i 380 4 guideline guideline NN cord-019043-cqmqwl3i 380 5 for for IN cord-019043-cqmqwl3i 380 6 acute acute JJ cord-019043-cqmqwl3i 380 7 kidney kidney NN cord-019043-cqmqwl3i 380 8 injury injury NN cord-019043-cqmqwl3i 380 9 Acute acute JJ cord-019043-cqmqwl3i 380 10 kidney kidney NN cord-019043-cqmqwl3i 380 11 injury injury NN cord-019043-cqmqwl3i 381 1 Acute acute JJ cord-019043-cqmqwl3i 381 2 renal renal JJ cord-019043-cqmqwl3i 381 3 failure failure NN cord-019043-cqmqwl3i 381 4 in in IN cord-019043-cqmqwl3i 381 5 critically critically RB cord-019043-cqmqwl3i 381 6 ill ill JJ cord-019043-cqmqwl3i 381 7 patients patient NNS cord-019043-cqmqwl3i 381 8 : : : cord-019043-cqmqwl3i 381 9 a a DT cord-019043-cqmqwl3i 381 10 multinational multinational JJ cord-019043-cqmqwl3i 381 11 , , , cord-019043-cqmqwl3i 381 12 multicenter multicenter JJ cord-019043-cqmqwl3i 381 13 study study NN cord-019043-cqmqwl3i 381 14 Chronic Chronic NNP cord-019043-cqmqwl3i 381 15 dialysis dialysis NN cord-019043-cqmqwl3i 381 16 and and CC cord-019043-cqmqwl3i 381 17 death death NN cord-019043-cqmqwl3i 381 18 among among IN cord-019043-cqmqwl3i 381 19 survivors survivor NNS cord-019043-cqmqwl3i 381 20 of of IN cord-019043-cqmqwl3i 381 21 acute acute JJ cord-019043-cqmqwl3i 381 22 kidney kidney NN cord-019043-cqmqwl3i 381 23 injury injury NN cord-019043-cqmqwl3i 381 24 requiring require VBG cord-019043-cqmqwl3i 381 25 dialysis dialysis NN cord-019043-cqmqwl3i 381 26 Prevention Prevention NNP cord-019043-cqmqwl3i 381 27 of of IN cord-019043-cqmqwl3i 381 28 acute acute JJ cord-019043-cqmqwl3i 381 29 kidney kidney NN cord-019043-cqmqwl3i 381 30 injury injury NN cord-019043-cqmqwl3i 381 31 and and CC cord-019043-cqmqwl3i 381 32 protection protection NN cord-019043-cqmqwl3i 381 33 of of IN cord-019043-cqmqwl3i 381 34 renal renal JJ cord-019043-cqmqwl3i 381 35 function function NN cord-019043-cqmqwl3i 381 36 in in IN cord-019043-cqmqwl3i 381 37 the the DT cord-019043-cqmqwl3i 381 38 intensive intensive JJ cord-019043-cqmqwl3i 381 39 care care NN cord-019043-cqmqwl3i 381 40 unit unit NN cord-019043-cqmqwl3i 381 41 . . . cord-019043-cqmqwl3i 382 1 Expert expert JJ cord-019043-cqmqwl3i 382 2 opinion opinion NN cord-019043-cqmqwl3i 382 3 of of IN cord-019043-cqmqwl3i 382 4 the the DT cord-019043-cqmqwl3i 382 5 working work VBG cord-019043-cqmqwl3i 382 6 group group NN cord-019043-cqmqwl3i 382 7 for for IN cord-019043-cqmqwl3i 382 8 nephrology nephrology NN cord-019043-cqmqwl3i 382 9 , , , cord-019043-cqmqwl3i 382 10 ESICM ESICM NNP cord-019043-cqmqwl3i 382 11 A a DT cord-019043-cqmqwl3i 382 12 comparison comparison NN cord-019043-cqmqwl3i 382 13 of of IN cord-019043-cqmqwl3i 382 14 early early JJ cord-019043-cqmqwl3i 382 15 versus versus IN cord-019043-cqmqwl3i 382 16 late late JJ cord-019043-cqmqwl3i 382 17 initiation initiation NN cord-019043-cqmqwl3i 382 18 of of IN cord-019043-cqmqwl3i 382 19 renal renal JJ cord-019043-cqmqwl3i 382 20 replacement replacement NN cord-019043-cqmqwl3i 382 21 therapy therapy NN cord-019043-cqmqwl3i 382 22 in in IN cord-019043-cqmqwl3i 382 23 critically critically RB cord-019043-cqmqwl3i 382 24 ill ill JJ cord-019043-cqmqwl3i 382 25 patients patient NNS cord-019043-cqmqwl3i 382 26 with with IN cord-019043-cqmqwl3i 382 27 acute acute JJ cord-019043-cqmqwl3i 382 28 kidney kidney NN cord-019043-cqmqwl3i 382 29 injury injury NN cord-019043-cqmqwl3i 382 30 : : : cord-019043-cqmqwl3i 382 31 a a DT cord-019043-cqmqwl3i 382 32 systematic systematic JJ cord-019043-cqmqwl3i 382 33 review review NN cord-019043-cqmqwl3i 382 34 and and CC cord-019043-cqmqwl3i 382 35 meta meta NNP cord-019043-cqmqwl3i 382 36 - - HYPH cord-019043-cqmqwl3i 382 37 analysis analysis NN cord-019043-cqmqwl3i 382 38 Timing timing NN cord-019043-cqmqwl3i 382 39 of of IN cord-019043-cqmqwl3i 382 40 renal renal JJ cord-019043-cqmqwl3i 382 41 replacement replacement NN cord-019043-cqmqwl3i 382 42 therapy therapy NN cord-019043-cqmqwl3i 382 43 initiation initiation NN cord-019043-cqmqwl3i 382 44 in in IN cord-019043-cqmqwl3i 382 45 acute acute JJ cord-019043-cqmqwl3i 382 46 renal renal JJ cord-019043-cqmqwl3i 382 47 failure failure NN cord-019043-cqmqwl3i 382 48 : : : cord-019043-cqmqwl3i 382 49 a a DT cord-019043-cqmqwl3i 382 50 metaanalysis metaanalysis NN cord-019043-cqmqwl3i 382 51 Continuous Continuous NNP cord-019043-cqmqwl3i 382 52 versus versus IN cord-019043-cqmqwl3i 382 53 intermittent intermittent JJ cord-019043-cqmqwl3i 382 54 renal renal JJ cord-019043-cqmqwl3i 382 55 replacement replacement NN cord-019043-cqmqwl3i 382 56 therapy therapy NN cord-019043-cqmqwl3i 382 57 for for IN cord-019043-cqmqwl3i 382 58 critically critically RB cord-019043-cqmqwl3i 382 59 ill ill JJ cord-019043-cqmqwl3i 382 60 patients patient NNS cord-019043-cqmqwl3i 382 61 with with IN cord-019043-cqmqwl3i 382 62 acute acute JJ cord-019043-cqmqwl3i 382 63 kidney kidney NN cord-019043-cqmqwl3i 382 64 injury injury NN cord-019043-cqmqwl3i 382 65 : : : cord-019043-cqmqwl3i 382 66 a a DT cord-019043-cqmqwl3i 382 67 meta meta JJ cord-019043-cqmqwl3i 382 68 - - HYPH cord-019043-cqmqwl3i 382 69 analysis analysis NN cord-019043-cqmqwl3i 382 70 Choice Choice NNP cord-019043-cqmqwl3i 382 71 of of IN cord-019043-cqmqwl3i 382 72 renal renal JJ cord-019043-cqmqwl3i 382 73 replacement replacement NN cord-019043-cqmqwl3i 382 74 therapy therapy NN cord-019043-cqmqwl3i 382 75 modality modality NN cord-019043-cqmqwl3i 382 76 and and CC cord-019043-cqmqwl3i 382 77 dialysis dialysis NN cord-019043-cqmqwl3i 382 78 dependence dependence NN cord-019043-cqmqwl3i 382 79 after after IN cord-019043-cqmqwl3i 382 80 acute acute JJ cord-019043-cqmqwl3i 382 81 kidney kidney NN cord-019043-cqmqwl3i 382 82 injury injury NN cord-019043-cqmqwl3i 382 83 : : : cord-019043-cqmqwl3i 382 84 a a DT cord-019043-cqmqwl3i 382 85 systematic systematic JJ cord-019043-cqmqwl3i 382 86 review review NN cord-019043-cqmqwl3i 382 87 and and CC cord-019043-cqmqwl3i 382 88 meta meta NNP cord-019043-cqmqwl3i 382 89 - - HYPH cord-019043-cqmqwl3i 382 90 analysis analysis NN cord-019043-cqmqwl3i 382 91 Hemofiltration Hemofiltration NNP cord-019043-cqmqwl3i 382 92 compared compare VBN cord-019043-cqmqwl3i 382 93 to to IN cord-019043-cqmqwl3i 382 94 hemodialysis hemodialysis NN cord-019043-cqmqwl3i 382 95 for for IN cord-019043-cqmqwl3i 382 96 acute acute JJ cord-019043-cqmqwl3i 382 97 kidney kidney NN cord-019043-cqmqwl3i 382 98 injury injury NN cord-019043-cqmqwl3i 382 99 : : : cord-019043-cqmqwl3i 382 100 systematic systematic JJ cord-019043-cqmqwl3i 382 101 review review NN cord-019043-cqmqwl3i 382 102 and and CC cord-019043-cqmqwl3i 382 103 meta meta NNP cord-019043-cqmqwl3i 382 104 - - HYPH cord-019043-cqmqwl3i 382 105 analysis analysis NN cord-019043-cqmqwl3i 382 106 Intensity intensity NN cord-019043-cqmqwl3i 382 107 of of IN cord-019043-cqmqwl3i 382 108 continuous continuous JJ cord-019043-cqmqwl3i 382 109 renal renal JJ cord-019043-cqmqwl3i 382 110 - - HYPH cord-019043-cqmqwl3i 382 111 replacement replacement NN cord-019043-cqmqwl3i 382 112 therapy therapy NN cord-019043-cqmqwl3i 382 113 in in IN cord-019043-cqmqwl3i 382 114 critically critically RB cord-019043-cqmqwl3i 382 115 ill ill JJ cord-019043-cqmqwl3i 382 116 patients patient NNS cord-019043-cqmqwl3i 382 117 Intensity intensity NN cord-019043-cqmqwl3i 382 118 of of IN cord-019043-cqmqwl3i 382 119 renal renal JJ cord-019043-cqmqwl3i 382 120 support support NN cord-019043-cqmqwl3i 382 121 in in IN cord-019043-cqmqwl3i 382 122 critically critically RB cord-019043-cqmqwl3i 382 123 ill ill JJ cord-019043-cqmqwl3i 382 124 patients patient NNS cord-019043-cqmqwl3i 382 125 with with IN cord-019043-cqmqwl3i 382 126 acute acute JJ cord-019043-cqmqwl3i 382 127 kidney kidney NN cord-019043-cqmqwl3i 382 128 injury injury NN cord-019043-cqmqwl3i 382 129 Drug Drug NNP cord-019043-cqmqwl3i 382 130 dosing dosing NN cord-019043-cqmqwl3i 382 131 consideration consideration NN cord-019043-cqmqwl3i 382 132 in in IN cord-019043-cqmqwl3i 382 133 patients patient NNS cord-019043-cqmqwl3i 382 134 with with IN cord-019043-cqmqwl3i 382 135 acute acute JJ cord-019043-cqmqwl3i 382 136 and and CC cord-019043-cqmqwl3i 382 137 chronic chronic JJ cord-019043-cqmqwl3i 382 138 kidney kidney NN cord-019043-cqmqwl3i 382 139 disease disease NN cord-019043-cqmqwl3i 382 140 - - : cord-019043-cqmqwl3i 382 141 a a DT cord-019043-cqmqwl3i 382 142 clinical clinical JJ cord-019043-cqmqwl3i 382 143 update update NN cord-019043-cqmqwl3i 382 144 from from IN cord-019043-cqmqwl3i 382 145 Kidney Kidney NNP cord-019043-cqmqwl3i 382 146 Disease Disease NNP cord-019043-cqmqwl3i 382 147 : : : cord-019043-cqmqwl3i 383 1 Improving improve VBG cord-019043-cqmqwl3i 383 2 Global Global NNP cord-019043-cqmqwl3i 383 3 Outcomes Outcomes NNPS cord-019043-cqmqwl3i 383 4 ( ( -LRB- cord-019043-cqmqwl3i 383 5 KDIGO KDIGO NNP cord-019043-cqmqwl3i 383 6 ) ) -RRB- cord-019043-cqmqwl3i 384 1 Antimicrobial antimicrobial JJ cord-019043-cqmqwl3i 384 2 dosing dosing NN cord-019043-cqmqwl3i 384 3 concepts concept NNS cord-019043-cqmqwl3i 384 4 and and CC cord-019043-cqmqwl3i 384 5 recommendations recommendation NNS cord-019043-cqmqwl3i 384 6 for for IN cord-019043-cqmqwl3i 384 7 critically critically RB cord-019043-cqmqwl3i 384 8 ill ill JJ cord-019043-cqmqwl3i 384 9 adult adult NN cord-019043-cqmqwl3i 384 10 patients patient NNS cord-019043-cqmqwl3i 384 11 receiving receive VBG cord-019043-cqmqwl3i 384 12 continuous continuous JJ cord-019043-cqmqwl3i 384 13 renal renal JJ cord-019043-cqmqwl3i 384 14 replacement replacement NN cord-019043-cqmqwl3i 384 15 therapy therapy NN cord-019043-cqmqwl3i 384 16 or or CC cord-019043-cqmqwl3i 384 17 intermittent intermittent JJ cord-019043-cqmqwl3i 384 18 hemodialysis hemodialysis NN