id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303344-4aeu9n5v	Honke, Nadine	Multiple functions of USP18	2016-11-03		.txt	text/plain	5890	382	45	Lacking of USP18 leads to an increase signaling of IFN-I, IFN-III, TNF-α and high levels of conjugated ISG15 Interestingly, knockout mice generated on the FVB/N genetic background are more viable and do not exhibit the severe neurological symptoms that occur in mice generated on a C57BL/6 background, which develop brain injury because of necrosis of ependymal cells. 53 In addition to ISG15, USP18 also specifically inhibits K63-linked ubiquitination of NEMO, leading to the negative regulation of NF-κB activation induced by the TAK1-TAB complex. As expected, this upregulation inhibits IFN-I-induced genes in human microvascular endothelial cells; however, whether USP18 plays a role in controlling bacterial infection has not yet been fully clarified. Because DCs express more USP18 than do other types of cells, the lack of a response to the antiviral effect of IFN-I leads to augmented viral replication and a sufficient amount of autoantigen.	./cache/cord-303344-4aeu9n5v.txt	./txt/cord-303344-4aeu9n5v.txt