id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312386-88uwlmjx	Kuchipudi, Suresh V.	The Complex Role of STAT3 in Viral Infections	2015-06-25		.txt	text/plain	4633	261	39	Signal transducer and activators of transcription-3 (STAT3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. Signal transducers and activators of transcription (STATs) are a family of transcription factors that play crucial roles in regulating a number of diverse biological functions including cell proliferation, differentiation, apoptosis, inflammatory response, immunity, and angiogenesis [1] . The seemingly contradictory roles of STAT3 in viral infections raise a number of interesting questions: "what factors determine the switch between pro-and anti-inflammatory functions of STAT3?," "how are viruses able to exploit STAT3 signalling for their gene replication?," and "does STAT3 either negatively or positively regulate type 1 IFN response depending on the virus type involved?" Further in depth studies to dissect the role of STAT3 in viral infections could provide valuable insights into viral pathogenesis and development of novel antiviral therapies. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins	./cache/cord-312386-88uwlmjx.txt	./txt/cord-312386-88uwlmjx.txt