id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333600-k6ws97at	Mihm, Sabine	COVID-19: Possible Impact of the Genetic Background in IFNL Genes on Disease Outcomes	2020-04-28		.txt	text/plain	684	42	48	Host control of MHV infection is completely dependent on TLR7 triggering by viral RNA causing an immediate interferon (IFN) response [2] . Sex differences in TLR7 responses have been reported for humans -with female sex better coping with viral infection [4] [5] [6] -which is also a feature of COVID-19. Upon binding viral nucleic acid motifs, TLR7 induces the expression of type I IFNs (IFN-α and IFN-β) and the expression of the more recently described family of type III IFNs (IFN-λ [1] [2] [3] [4] . A common germ line genetic variation within the type III IFN gene locus has been most convincingly shown to determine the host's capacity to cope with an infection induced by hepatitis C virus (HCV), an enveloped ssRNA virus of positive orientation, too, featuring tropism for liver epithelial cells. CD200 receptor controls sex-specific TLR7 responses to viral infection IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes	./cache/cord-333600-k6ws97at.txt	./txt/cord-333600-k6ws97at.txt