id	sid	tid	token	lemma	pos
cord-252528-rgnhfcbx	1	1	key	key	NNP
cord-252528-rgnhfcbx	1	2	:	:	:
cord-252528-rgnhfcbx	1	3	cord-252528-rgnhfcbx	cord-252528-rgnhfcbx	NNP
cord-252528-rgnhfcbx	2	1	authors	author	NNS
cord-252528-rgnhfcbx	2	2	:	:	:
cord-252528-rgnhfcbx	2	3	Du	Du	NNP
cord-252528-rgnhfcbx	2	4	,	,	,
cord-252528-rgnhfcbx	2	5	Fenghe	Fenghe	NNP
cord-252528-rgnhfcbx	2	6	;	;	:
cord-252528-rgnhfcbx	2	7	Liu	Liu	NNP
cord-252528-rgnhfcbx	2	8	,	,	,
cord-252528-rgnhfcbx	2	9	Bao	Bao	NNP
cord-252528-rgnhfcbx	2	10	;	;	:
cord-252528-rgnhfcbx	2	11	Zhang	Zhang	NNP
cord-252528-rgnhfcbx	2	12	,	,	,
cord-252528-rgnhfcbx	2	13	Shuyang	Shuyang	NNP
cord-252528-rgnhfcbx	2	14	title	title	NN
cord-252528-rgnhfcbx	2	15	:	:	:
cord-252528-rgnhfcbx	3	1	COVID-19	covid-19	VB
cord-252528-rgnhfcbx	3	2	:	:	:
cord-252528-rgnhfcbx	3	3	the	the	DT
cord-252528-rgnhfcbx	3	4	role	role	NN
cord-252528-rgnhfcbx	3	5	of	of	IN
cord-252528-rgnhfcbx	3	6	excessive	excessive	JJ
cord-252528-rgnhfcbx	3	7	cytokine	cytokine	NN
cord-252528-rgnhfcbx	3	8	release	release	NN
cord-252528-rgnhfcbx	3	9	and	and	CC
cord-252528-rgnhfcbx	3	10	potential	potential	JJ
cord-252528-rgnhfcbx	3	11	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	3	12	down	down	NN
cord-252528-rgnhfcbx	3	13	-	-	HYPH
cord-252528-rgnhfcbx	3	14	regulation	regulation	NN
cord-252528-rgnhfcbx	3	15	in	in	IN
cord-252528-rgnhfcbx	3	16	promoting	promote	VBG
cord-252528-rgnhfcbx	3	17	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	3	18	state	state	NN
cord-252528-rgnhfcbx	3	19	associated	associate	VBN
cord-252528-rgnhfcbx	3	20	with	with	IN
cord-252528-rgnhfcbx	3	21	severe	severe	JJ
cord-252528-rgnhfcbx	3	22	illness	illness	NN
cord-252528-rgnhfcbx	3	23	date	date	NN
cord-252528-rgnhfcbx	3	24	:	:	:
cord-252528-rgnhfcbx	3	25	2020	2020	CD
cord-252528-rgnhfcbx	3	26	-	-	HYPH
cord-252528-rgnhfcbx	3	27	07	07	CD
cord-252528-rgnhfcbx	3	28	-	-	HYPH
cord-252528-rgnhfcbx	3	29	16	16	CD
cord-252528-rgnhfcbx	3	30	journal	journal	NN
cord-252528-rgnhfcbx	3	31	:	:	:
cord-252528-rgnhfcbx	4	1	J	J	NNP
cord-252528-rgnhfcbx	4	2	Thromb	Thromb	NNP
cord-252528-rgnhfcbx	4	3	Thrombolysis	Thrombolysis	NNP
cord-252528-rgnhfcbx	4	4	DOI	DOI	NNP
cord-252528-rgnhfcbx	4	5	:	:	:
cord-252528-rgnhfcbx	4	6	10.1007	10.1007	CD
cord-252528-rgnhfcbx	4	7	/	/	SYM
cord-252528-rgnhfcbx	4	8	s11239	s11239	CD
cord-252528-rgnhfcbx	4	9	-	-	HYPH
cord-252528-rgnhfcbx	4	10	020	020	CD
cord-252528-rgnhfcbx	4	11	-	-	HYPH
cord-252528-rgnhfcbx	4	12	02224	02224	CD
cord-252528-rgnhfcbx	4	13	-	-	SYM
cord-252528-rgnhfcbx	4	14	2	2	CD
cord-252528-rgnhfcbx	5	1	sha	sha	NNP
cord-252528-rgnhfcbx	5	2	:	:	:
cord-252528-rgnhfcbx	6	1	5b45f12f3ea9437aafb26022a2de293bf008d7ae	5b45f12f3ea9437aafb26022a2de293bf008d7ae	CD
cord-252528-rgnhfcbx	6	2	doc_id	doc_id	CD
cord-252528-rgnhfcbx	6	3	:	:	:
cord-252528-rgnhfcbx	6	4	252528	252528	CD
cord-252528-rgnhfcbx	6	5	cord_uid	cord_uid	NNS
cord-252528-rgnhfcbx	6	6	:	:	:
cord-252528-rgnhfcbx	6	7	rgnhfcbx	rgnhfcbx	NN
cord-252528-rgnhfcbx	6	8	[	[	-LRB-
cord-252528-rgnhfcbx	6	9	Image	image	NN
cord-252528-rgnhfcbx	6	10	:	:	:
cord-252528-rgnhfcbx	6	11	see	see	VB
cord-252528-rgnhfcbx	6	12	text	text	NN
cord-252528-rgnhfcbx	6	13	]	]	-RRB-
cord-252528-rgnhfcbx	7	1	Keywords	Keywords	NNPS
cord-252528-rgnhfcbx	7	2	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	7	3	·	·	NFP
cord-252528-rgnhfcbx	7	4	Excessive	excessive	JJ
cord-252528-rgnhfcbx	7	5	cytokine	cytokine	NN
cord-252528-rgnhfcbx	7	6	release	release	NN
cord-252528-rgnhfcbx	7	7	·	·	NFP
cord-252528-rgnhfcbx	7	8	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	7	9	·	·	NFP
cord-252528-rgnhfcbx	7	10	Hypercoagulable	hypercoagulable	NN
cord-252528-rgnhfcbx	7	11	state	state	NN
cord-252528-rgnhfcbx	7	12	·	·	.
cord-252528-rgnhfcbx	7	13	Vascular	vascular	JJ
cord-252528-rgnhfcbx	7	14	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	7	15	events	event	NNS
cord-252528-rgnhfcbx	8	1	Highlights	highlight	NNS
cord-252528-rgnhfcbx	9	1	•	•	NNP
cord-252528-rgnhfcbx	10	1	Dysregulated	dysregulated	JJ
cord-252528-rgnhfcbx	10	2	immune	immune	JJ
cord-252528-rgnhfcbx	10	3	responses	response	NNS
cord-252528-rgnhfcbx	10	4	in	in	IN
cord-252528-rgnhfcbx	10	5	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	10	6	could	could	MD
cord-252528-rgnhfcbx	10	7	lead	lead	VB
cord-252528-rgnhfcbx	10	8	to	to	IN
cord-252528-rgnhfcbx	10	9	inefficient	inefficient	JJ
cord-252528-rgnhfcbx	10	10	virus	virus	NN
cord-252528-rgnhfcbx	10	11	clearance	clearance	NN
cord-252528-rgnhfcbx	10	12	,	,	,
cord-252528-rgnhfcbx	10	13	which	which	WDT
cord-252528-rgnhfcbx	10	14	further	further	RB
cord-252528-rgnhfcbx	10	15	brings	bring	VBZ
cord-252528-rgnhfcbx	10	16	about	about	RB
cord-252528-rgnhfcbx	10	17	over	over	RB
cord-252528-rgnhfcbx	10	18	-	-	HYPH
cord-252528-rgnhfcbx	10	19	activated	activate	VBN
cord-252528-rgnhfcbx	10	20	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	10	21	response	response	NN
cord-252528-rgnhfcbx	10	22	and	and	CC
cord-252528-rgnhfcbx	10	23	excessive	excessive	JJ
cord-252528-rgnhfcbx	10	24	cytokine	cytokine	NN
cord-252528-rgnhfcbx	10	25	release	release	NN
cord-252528-rgnhfcbx	10	26	.	.	.
cord-252528-rgnhfcbx	11	1	•	•	NNP
cord-252528-rgnhfcbx	12	1	Excessive	excessive	JJ
cord-252528-rgnhfcbx	12	2	cytokine	cytokine	NN
cord-252528-rgnhfcbx	12	3	release	release	NN
cord-252528-rgnhfcbx	12	4	in	in	IN
cord-252528-rgnhfcbx	12	5	severe	severe	JJ
cord-252528-rgnhfcbx	12	6	cases	case	NNS
cord-252528-rgnhfcbx	12	7	of	of	IN
cord-252528-rgnhfcbx	12	8	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	12	9	is	be	VBZ
cord-252528-rgnhfcbx	12	10	characterized	characterize	VBN
cord-252528-rgnhfcbx	12	11	by	by	IN
cord-252528-rgnhfcbx	12	12	enhanced	enhanced	JJ
cord-252528-rgnhfcbx	12	13	serum	serum	NN
cord-252528-rgnhfcbx	12	14	levels	level	NNS
cord-252528-rgnhfcbx	12	15	of	of	IN
cord-252528-rgnhfcbx	12	16	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	12	17	,	,	,
cord-252528-rgnhfcbx	12	18	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	12	19	,	,	,
cord-252528-rgnhfcbx	12	20	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	12	21	,	,	,
cord-252528-rgnhfcbx	12	22	and	and	CC
cord-252528-rgnhfcbx	12	23	IFN	IFN	NNP
cord-252528-rgnhfcbx	12	24	-	-	HYPH
cord-252528-rgnhfcbx	12	25	γ	γ	NNP
cord-252528-rgnhfcbx	12	26	.	.	.
cord-252528-rgnhfcbx	13	1	Increased	increase	VBN
cord-252528-rgnhfcbx	13	2	serum	serum	NN
cord-252528-rgnhfcbx	13	3	level	level	NN
cord-252528-rgnhfcbx	13	4	of	of	IN
cord-252528-rgnhfcbx	13	5	the	the	DT
cord-252528-rgnhfcbx	13	6	anti	anti	JJ
cord-252528-rgnhfcbx	13	7	-	-	JJ
cord-252528-rgnhfcbx	13	8	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	13	9	cytokine	cytokine	NN
cord-252528-rgnhfcbx	13	10	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	13	11	might	may	MD
cord-252528-rgnhfcbx	13	12	be	be	VB
cord-252528-rgnhfcbx	13	13	a	a	DT
cord-252528-rgnhfcbx	13	14	compensatory	compensatory	JJ
cord-252528-rgnhfcbx	13	15	mechanism	mechanism	NN
cord-252528-rgnhfcbx	13	16	to	to	TO
cord-252528-rgnhfcbx	13	17	reduce	reduce	VB
cord-252528-rgnhfcbx	13	18	the	the	DT
cord-252528-rgnhfcbx	13	19	over	over	RB
cord-252528-rgnhfcbx	13	20	-	-	HYPH
cord-252528-rgnhfcbx	13	21	activated	activate	VBN
cord-252528-rgnhfcbx	13	22	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	13	23	response	response	NN
cord-252528-rgnhfcbx	13	24	.	.	.
cord-252528-rgnhfcbx	14	1	•	•	NNP
cord-252528-rgnhfcbx	15	1	ACE2	ace2	JJ
cord-252528-rgnhfcbx	15	2	expression	expression	NN
cord-252528-rgnhfcbx	15	3	levels	level	NNS
cord-252528-rgnhfcbx	15	4	could	could	MD
cord-252528-rgnhfcbx	15	5	be	be	VB
cord-252528-rgnhfcbx	15	6	down	down	RB
cord-252528-rgnhfcbx	15	7	-	-	HYPH
cord-252528-rgnhfcbx	15	8	regulated	regulate	VBN
cord-252528-rgnhfcbx	15	9	,	,	,
cord-252528-rgnhfcbx	15	10	according	accord	VBG
cord-252528-rgnhfcbx	15	11	to	to	IN
cord-252528-rgnhfcbx	15	12	the	the	DT
cord-252528-rgnhfcbx	15	13	recent	recent	JJ
cord-252528-rgnhfcbx	15	14	bio	bio	JJ
cord-252528-rgnhfcbx	15	15	-	-	JJ
cord-252528-rgnhfcbx	15	16	informatic	informatic	JJ
cord-252528-rgnhfcbx	15	17	analysis	analysis	NN
cord-252528-rgnhfcbx	15	18	with	with	IN
cord-252528-rgnhfcbx	15	19	the	the	DT
cord-252528-rgnhfcbx	15	20	interactome	interactome	NNP
cord-252528-rgnhfcbx	15	21	model	model	NN
cord-252528-rgnhfcbx	15	22	based	base	VBN
cord-252528-rgnhfcbx	15	23	on	on	IN
cord-252528-rgnhfcbx	15	24	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	15	25	of	of	IN
cord-252528-rgnhfcbx	15	26	human	human	JJ
cord-252528-rgnhfcbx	15	27	protein	protein	NN
cord-252528-rgnhfcbx	15	28	/	/	SYM
cord-252528-rgnhfcbx	15	29	SARS	SARS	NNP
cord-252528-rgnhfcbx	15	30	-	-	HYPH
cord-252528-rgnhfcbx	15	31	CoV	cov	NN
cord-252528-rgnhfcbx	15	32	interactions	interaction	NNS
cord-252528-rgnhfcbx	15	33	,	,	,
cord-252528-rgnhfcbx	15	34	but	but	CC
cord-252528-rgnhfcbx	15	35	a	a	DT
cord-252528-rgnhfcbx	15	36	direct	direct	JJ
cord-252528-rgnhfcbx	15	37	experimental	experimental	JJ
cord-252528-rgnhfcbx	15	38	evidence	evidence	NN
cord-252528-rgnhfcbx	15	39	is	be	VBZ
cord-252528-rgnhfcbx	15	40	still	still	RB
cord-252528-rgnhfcbx	15	41	required	require	VBN
cord-252528-rgnhfcbx	15	42	to	to	TO
cord-252528-rgnhfcbx	15	43	confirm	confirm	VB
cord-252528-rgnhfcbx	15	44	this	this	DT
cord-252528-rgnhfcbx	15	45	prediction	prediction	NN
cord-252528-rgnhfcbx	15	46	.	.	.
cord-252528-rgnhfcbx	16	1	•	•	NNP
cord-252528-rgnhfcbx	17	1	In	in	IN
cord-252528-rgnhfcbx	17	2	severe	severe	JJ
cord-252528-rgnhfcbx	17	3	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	17	4	,	,	,
cord-252528-rgnhfcbx	17	5	the	the	DT
cord-252528-rgnhfcbx	17	6	excessive	excessive	JJ
cord-252528-rgnhfcbx	17	7	cytokine	cytokine	NN
cord-252528-rgnhfcbx	17	8	release	release	NN
cord-252528-rgnhfcbx	17	9	and	and	CC
cord-252528-rgnhfcbx	17	10	potential	potential	JJ
cord-252528-rgnhfcbx	17	11	down	down	JJ
cord-252528-rgnhfcbx	17	12	-	-	HYPH
cord-252528-rgnhfcbx	17	13	regulation	regulation	NN
cord-252528-rgnhfcbx	17	14	in	in	IN
cord-252528-rgnhfcbx	17	15	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	17	16	expressions	expression	NNS
cord-252528-rgnhfcbx	17	17	can	can	MD
cord-252528-rgnhfcbx	17	18	not	not	RB
cord-252528-rgnhfcbx	17	19	only	only	RB
cord-252528-rgnhfcbx	17	20	promote	promote	VB
cord-252528-rgnhfcbx	17	21	a	a	DT
cord-252528-rgnhfcbx	17	22	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	17	23	state	state	NN
cord-252528-rgnhfcbx	17	24	individually	individually	RB
cord-252528-rgnhfcbx	17	25	,	,	,
cord-252528-rgnhfcbx	17	26	but	but	CC
cord-252528-rgnhfcbx	17	27	also	also	RB
cord-252528-rgnhfcbx	17	28	reciprocally	reciprocally	RB
cord-252528-rgnhfcbx	17	29	enhance	enhance	VB
cord-252528-rgnhfcbx	17	30	the	the	DT
cord-252528-rgnhfcbx	17	31	pro	pro	JJ
cord-252528-rgnhfcbx	17	32	-	-	JJ
cord-252528-rgnhfcbx	17	33	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	17	34	functions	function	NNS
cord-252528-rgnhfcbx	17	35	of	of	IN
cord-252528-rgnhfcbx	17	36	each	each	DT
cord-252528-rgnhfcbx	17	37	other	other	JJ
cord-252528-rgnhfcbx	17	38	.	.	.
cord-252528-rgnhfcbx	18	1	•	•	NNP
cord-252528-rgnhfcbx	18	2	Anti	anti	JJ
cord-252528-rgnhfcbx	18	3	-	-	JJ
cord-252528-rgnhfcbx	18	4	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	18	5	therapies	therapy	NNS
cord-252528-rgnhfcbx	18	6	,	,	,
cord-252528-rgnhfcbx	18	7	including	include	VBG
cord-252528-rgnhfcbx	18	8	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	18	9	,	,	,
cord-252528-rgnhfcbx	18	10	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	18	11	,	,	,
cord-252528-rgnhfcbx	18	12	and	and	CC
cord-252528-rgnhfcbx	18	13	hydroxychloroquine	hydroxychloroquine	NNP
cord-252528-rgnhfcbx	18	14	,	,	,
cord-252528-rgnhfcbx	18	15	which	which	WDT
cord-252528-rgnhfcbx	18	16	can	can	MD
cord-252528-rgnhfcbx	18	17	be	be	VB
cord-252528-rgnhfcbx	18	18	promising	promising	JJ
cord-252528-rgnhfcbx	18	19	treatment	treatment	NN
cord-252528-rgnhfcbx	18	20	to	to	TO
cord-252528-rgnhfcbx	18	21	control	control	VB
cord-252528-rgnhfcbx	18	22	excessive	excessive	JJ
cord-252528-rgnhfcbx	18	23	cytokine	cytokine	NN
cord-252528-rgnhfcbx	18	24	release	release	NN
cord-252528-rgnhfcbx	18	25	in	in	IN
cord-252528-rgnhfcbx	18	26	severe	severe	JJ
cord-252528-rgnhfcbx	18	27	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	18	28	,	,	,
cord-252528-rgnhfcbx	18	29	have	have	VBP
cord-252528-rgnhfcbx	18	30	the	the	DT
cord-252528-rgnhfcbx	18	31	potential	potential	NN
cord-252528-rgnhfcbx	18	32	to	to	TO
cord-252528-rgnhfcbx	18	33	reduce	reduce	VB
cord-252528-rgnhfcbx	18	34	the	the	DT
cord-252528-rgnhfcbx	18	35	risk	risk	NN
cord-252528-rgnhfcbx	18	36	of	of	IN
cord-252528-rgnhfcbx	18	37	vascular	vascular	JJ
cord-252528-rgnhfcbx	18	38	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	18	39	events	event	NNS
cord-252528-rgnhfcbx	18	40	,	,	,
cord-252528-rgnhfcbx	18	41	but	but	CC
cord-252528-rgnhfcbx	18	42	more	more	JJR
cord-252528-rgnhfcbx	18	43	clinical	clinical	JJ
cord-252528-rgnhfcbx	18	44	data	datum	NNS
cord-252528-rgnhfcbx	18	45	are	be	VBP
cord-252528-rgnhfcbx	18	46	needed	need	VBN
cord-252528-rgnhfcbx	18	47	for	for	IN
cord-252528-rgnhfcbx	18	48	optimum	optimum	JJ
cord-252528-rgnhfcbx	18	49	instruction	instruction	NN
cord-252528-rgnhfcbx	18	50	of	of	IN
cord-252528-rgnhfcbx	18	51	drug	drug	NN
cord-252528-rgnhfcbx	18	52	use	use	NN
cord-252528-rgnhfcbx	18	53	and	and	CC
cord-252528-rgnhfcbx	18	54	drug	drug	NN
cord-252528-rgnhfcbx	18	55	selection	selection	NN
cord-252528-rgnhfcbx	18	56	.	.	.
cord-252528-rgnhfcbx	19	1	The	the	DT
cord-252528-rgnhfcbx	19	2	novel	novel	JJ
cord-252528-rgnhfcbx	19	3	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	19	4	disease	disease	NN
cord-252528-rgnhfcbx	19	5	,	,	,
cord-252528-rgnhfcbx	19	6	caused	cause	VBN
cord-252528-rgnhfcbx	19	7	by	by	IN
cord-252528-rgnhfcbx	19	8	severe	severe	JJ
cord-252528-rgnhfcbx	19	9	acute	acute	JJ
cord-252528-rgnhfcbx	19	10	respiratory	respiratory	JJ
cord-252528-rgnhfcbx	19	11	syndrome	syndrome	NN
cord-252528-rgnhfcbx	19	12	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	19	13	type	type	NN
cord-252528-rgnhfcbx	19	14	2	2	CD
cord-252528-rgnhfcbx	20	1	(	(	-LRB-
cord-252528-rgnhfcbx	20	2	SARS	SARS	NNP
cord-252528-rgnhfcbx	20	3	-	-	HYPH
cord-252528-rgnhfcbx	20	4	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	20	5	)	)	-RRB-
cord-252528-rgnhfcbx	20	6	infection	infection	NN
cord-252528-rgnhfcbx	20	7	,	,	,
cord-252528-rgnhfcbx	20	8	is	be	VBZ
cord-252528-rgnhfcbx	20	9	currently	currently	RB
cord-252528-rgnhfcbx	20	10	leading	lead	VBG
cord-252528-rgnhfcbx	20	11	to	to	IN
cord-252528-rgnhfcbx	20	12	a	a	DT
cord-252528-rgnhfcbx	20	13	global	global	JJ
cord-252528-rgnhfcbx	20	14	pandemic	pandemic	NN
cord-252528-rgnhfcbx	20	15	.	.	.
cord-252528-rgnhfcbx	21	1	Clinical	clinical	JJ
cord-252528-rgnhfcbx	21	2	studies	study	NNS
cord-252528-rgnhfcbx	21	3	so	so	RB
cord-252528-rgnhfcbx	21	4	far	far	RB
cord-252528-rgnhfcbx	21	5	have	have	VBP
cord-252528-rgnhfcbx	21	6	demonstrated	demonstrate	VBN
cord-252528-rgnhfcbx	21	7	an	an	DT
cord-252528-rgnhfcbx	21	8	association	association	NN
cord-252528-rgnhfcbx	21	9	between	between	IN
cord-252528-rgnhfcbx	21	10	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	21	11	severity	severity	NN
cord-252528-rgnhfcbx	21	12	and	and	CC
cord-252528-rgnhfcbx	21	13	vascular	vascular	JJ
cord-252528-rgnhfcbx	21	14	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	21	15	or	or	CC
cord-252528-rgnhfcbx	21	16	thromboembolic	thromboembolic	JJ
cord-252528-rgnhfcbx	21	17	events	event	NNS
cord-252528-rgnhfcbx	21	18	[	[	-LRB-
cord-252528-rgnhfcbx	21	19	1	1	CD
cord-252528-rgnhfcbx	21	20	]	]	-RRB-
cord-252528-rgnhfcbx	21	21	.	.	.
cord-252528-rgnhfcbx	22	1	Moreover	moreover	RB
cord-252528-rgnhfcbx	22	2	,	,	,
cord-252528-rgnhfcbx	22	3	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	22	4	severity	severity	NN
cord-252528-rgnhfcbx	22	5	is	be	VBZ
cord-252528-rgnhfcbx	22	6	also	also	RB
cord-252528-rgnhfcbx	22	7	frequently	frequently	RB
cord-252528-rgnhfcbx	22	8	associated	associate	VBN
cord-252528-rgnhfcbx	22	9	with	with	IN
cord-252528-rgnhfcbx	22	10	over	over	RB
cord-252528-rgnhfcbx	22	11	-	-	HYPH
cord-252528-rgnhfcbx	22	12	activated	activate	VBN
cord-252528-rgnhfcbx	22	13	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	22	14	response	response	NN
cord-252528-rgnhfcbx	22	15	characterized	characterize	VBN
cord-252528-rgnhfcbx	22	16	by	by	IN
cord-252528-rgnhfcbx	22	17	excessive	excessive	JJ
cord-252528-rgnhfcbx	22	18	cytokine	cytokine	NN
cord-252528-rgnhfcbx	22	19	release	release	NN
cord-252528-rgnhfcbx	22	20	[	[	-LRB-
cord-252528-rgnhfcbx	22	21	2	2	CD
cord-252528-rgnhfcbx	22	22	]	]	-RRB-
cord-252528-rgnhfcbx	22	23	[	[	-LRB-
cord-252528-rgnhfcbx	22	24	3	3	CD
cord-252528-rgnhfcbx	22	25	]	]	-RRB-
cord-252528-rgnhfcbx	22	26	[	[	-LRB-
cord-252528-rgnhfcbx	22	27	4	4	CD
cord-252528-rgnhfcbx	22	28	]	]	-RRB-
cord-252528-rgnhfcbx	22	29	[	[	-LRB-
cord-252528-rgnhfcbx	22	30	5	5	CD
cord-252528-rgnhfcbx	22	31	]	]	-RRB-
cord-252528-rgnhfcbx	22	32	[	[	-LRB-
cord-252528-rgnhfcbx	22	33	6	6	CD
cord-252528-rgnhfcbx	22	34	]	]	-RRB-
cord-252528-rgnhfcbx	22	35	.	.	.
cord-252528-rgnhfcbx	23	1	To	to	TO
cord-252528-rgnhfcbx	23	2	prevent	prevent	VB
cord-252528-rgnhfcbx	23	3	the	the	DT
cord-252528-rgnhfcbx	23	4	vascular	vascular	JJ
cord-252528-rgnhfcbx	23	5	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	23	6	events	event	NNS
cord-252528-rgnhfcbx	23	7	in	in	IN
cord-252528-rgnhfcbx	23	8	severe	severe	JJ
cord-252528-rgnhfcbx	23	9	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	23	10	,	,	,
cord-252528-rgnhfcbx	23	11	it	-PRON-	PRP
cord-252528-rgnhfcbx	23	12	is	be	VBZ
cord-252528-rgnhfcbx	23	13	urgently	urgently	RB
cord-252528-rgnhfcbx	23	14	necessary	necessary	JJ
cord-252528-rgnhfcbx	23	15	to	to	TO
cord-252528-rgnhfcbx	23	16	understand	understand	VB
cord-252528-rgnhfcbx	23	17	the	the	DT
cord-252528-rgnhfcbx	23	18	underlying	underlie	VBG
cord-252528-rgnhfcbx	23	19	pathogenic	pathogenic	JJ
cord-252528-rgnhfcbx	23	20	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	23	21	.	.	.
cord-252528-rgnhfcbx	24	1	Based	base	VBN
cord-252528-rgnhfcbx	24	2	on	on	IN
cord-252528-rgnhfcbx	24	3	currently	currently	RB
cord-252528-rgnhfcbx	24	4	available	available	JJ
cord-252528-rgnhfcbx	24	5	evidence	evidence	NN
cord-252528-rgnhfcbx	24	6	,	,	,
cord-252528-rgnhfcbx	24	7	we	-PRON-	PRP
cord-252528-rgnhfcbx	24	8	discuss	discuss	VBP
cord-252528-rgnhfcbx	24	9	the	the	DT
cord-252528-rgnhfcbx	24	10	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	24	11	of	of	IN
cord-252528-rgnhfcbx	24	12	initiation	initiation	NN
cord-252528-rgnhfcbx	24	13	,	,	,
cord-252528-rgnhfcbx	24	14	the	the	DT
cord-252528-rgnhfcbx	24	15	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	24	16	,	,	,
cord-252528-rgnhfcbx	24	17	and	and	CC
cord-252528-rgnhfcbx	24	18	the	the	DT
cord-252528-rgnhfcbx	24	19	immuno	immuno	JJ
cord-252528-rgnhfcbx	24	20	-	-	JJ
cord-252528-rgnhfcbx	24	21	pathological	pathological	JJ
cord-252528-rgnhfcbx	24	22	basis	basis	NN
cord-252528-rgnhfcbx	24	23	of	of	IN
cord-252528-rgnhfcbx	24	24	the	the	DT
cord-252528-rgnhfcbx	24	25	over	over	RB
cord-252528-rgnhfcbx	24	26	-	-	HYPH
cord-252528-rgnhfcbx	24	27	activated	activate	VBN
cord-252528-rgnhfcbx	24	28	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	24	29	response	response	NN
cord-252528-rgnhfcbx	24	30	associated	associate	VBN
cord-252528-rgnhfcbx	24	31	with	with	IN
cord-252528-rgnhfcbx	24	32	severe	severe	JJ
cord-252528-rgnhfcbx	24	33	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	24	34	.	.	.
cord-252528-rgnhfcbx	25	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	25	2	,	,	,
cord-252528-rgnhfcbx	25	3	we	-PRON-	PRP
cord-252528-rgnhfcbx	25	4	summarize	summarize	VBP
cord-252528-rgnhfcbx	25	5	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	25	6	that	that	WDT
cord-252528-rgnhfcbx	25	7	have	have	VBP
cord-252528-rgnhfcbx	25	8	consistently	consistently	RB
cord-252528-rgnhfcbx	25	9	displayed	display	VBN
cord-252528-rgnhfcbx	25	10	enhanced	enhanced	JJ
cord-252528-rgnhfcbx	25	11	serum	serum	NN
cord-252528-rgnhfcbx	25	12	levels	level	NNS
cord-252528-rgnhfcbx	25	13	in	in	IN
cord-252528-rgnhfcbx	25	14	severe	severe	JJ
cord-252528-rgnhfcbx	25	15	patients	patient	NNS
cord-252528-rgnhfcbx	25	16	.	.	.
cord-252528-rgnhfcbx	26	1	Mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	26	2	through	through	IN
cord-252528-rgnhfcbx	26	3	which	which	WDT
cord-252528-rgnhfcbx	26	4	these	these	DT
cord-252528-rgnhfcbx	26	5	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	26	6	influence	influence	VBP
cord-252528-rgnhfcbx	26	7	the	the	DT
cord-252528-rgnhfcbx	26	8	coagulable	coagulable	JJ
cord-252528-rgnhfcbx	26	9	state	state	NN
cord-252528-rgnhfcbx	26	10	are	be	VBP
cord-252528-rgnhfcbx	26	11	reviewed	review	VBN
cord-252528-rgnhfcbx	26	12	in	in	IN
cord-252528-rgnhfcbx	26	13	detail	detail	NN
cord-252528-rgnhfcbx	26	14	after	after	IN
cord-252528-rgnhfcbx	26	15	an	an	DT
cord-252528-rgnhfcbx	26	16	overview	overview	NN
cord-252528-rgnhfcbx	26	17	of	of	IN
cord-252528-rgnhfcbx	26	18	the	the	DT
cord-252528-rgnhfcbx	26	19	role	role	NN
cord-252528-rgnhfcbx	26	20	of	of	IN
cord-252528-rgnhfcbx	26	21	excessive	excessive	JJ
cord-252528-rgnhfcbx	26	22	pro	pro	JJ
cord-252528-rgnhfcbx	26	23	-	-	JJ
cord-252528-rgnhfcbx	26	24	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	26	25	cytokine	cytokine	NN
cord-252528-rgnhfcbx	26	26	release	release	NN
cord-252528-rgnhfcbx	26	27	in	in	IN
cord-252528-rgnhfcbx	26	28	promoting	promote	VBG
cord-252528-rgnhfcbx	26	29	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	26	30	state	state	NN
cord-252528-rgnhfcbx	26	31	in	in	IN
cord-252528-rgnhfcbx	26	32	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	26	33	.	.	.
cord-252528-rgnhfcbx	27	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	27	2	,	,	,
cord-252528-rgnhfcbx	27	3	we	-PRON-	PRP
cord-252528-rgnhfcbx	27	4	discuss	discuss	VBP
cord-252528-rgnhfcbx	27	5	the	the	DT
cord-252528-rgnhfcbx	27	6	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	27	7	and	and	CC
cord-252528-rgnhfcbx	27	8	potential	potential	NN
cord-252528-rgnhfcbx	27	9	of	of	IN
cord-252528-rgnhfcbx	27	10	anti	anti	JJ
cord-252528-rgnhfcbx	27	11	-	-	JJ
cord-252528-rgnhfcbx	27	12	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	27	13	medications	medication	NNS
cord-252528-rgnhfcbx	27	14	investigated	investigate	VBN
cord-252528-rgnhfcbx	27	15	in	in	IN
cord-252528-rgnhfcbx	27	16	recent	recent	JJ
cord-252528-rgnhfcbx	27	17	clinical	clinical	JJ
cord-252528-rgnhfcbx	27	18	trials	trial	NNS
cord-252528-rgnhfcbx	27	19	to	to	TO
cord-252528-rgnhfcbx	27	20	prevent	prevent	VB
cord-252528-rgnhfcbx	27	21	the	the	DT
cord-252528-rgnhfcbx	27	22	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	27	23	state	state	NN
cord-252528-rgnhfcbx	27	24	in	in	IN
cord-252528-rgnhfcbx	27	25	severe	severe	JJ
cord-252528-rgnhfcbx	27	26	COVID-	covid-	NN
cord-252528-rgnhfcbx	27	27	19	19	CD
cord-252528-rgnhfcbx	27	28	.	.	.
cord-252528-rgnhfcbx	28	1	Despite	despite	IN
cord-252528-rgnhfcbx	28	2	a	a	DT
cord-252528-rgnhfcbx	28	3	lack	lack	NN
cord-252528-rgnhfcbx	28	4	of	of	IN
cord-252528-rgnhfcbx	28	5	direct	direct	JJ
cord-252528-rgnhfcbx	28	6	evidence	evidence	NN
cord-252528-rgnhfcbx	28	7	showing	show	VBG
cord-252528-rgnhfcbx	28	8	a	a	DT
cord-252528-rgnhfcbx	28	9	downregulation	downregulation	NN
cord-252528-rgnhfcbx	28	10	of	of	IN
cord-252528-rgnhfcbx	28	11	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	28	12	-	-	HYPH
cord-252528-rgnhfcbx	28	13	converting	convert	VBG
cord-252528-rgnhfcbx	28	14	enzyme	enzyme	NN
cord-252528-rgnhfcbx	28	15	2	2	CD
cord-252528-rgnhfcbx	28	16	(	(	-LRB-
cord-252528-rgnhfcbx	28	17	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	28	18	)	)	-RRB-
cord-252528-rgnhfcbx	28	19	expression	expression	NN
cord-252528-rgnhfcbx	28	20	levels	level	NNS
cord-252528-rgnhfcbx	28	21	in	in	IN
cord-252528-rgnhfcbx	28	22	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	28	23	,	,	,
cord-252528-rgnhfcbx	28	24	a	a	DT
cord-252528-rgnhfcbx	28	25	recent	recent	JJ
cord-252528-rgnhfcbx	28	26	bio	bio	JJ
cord-252528-rgnhfcbx	28	27	-	-	JJ
cord-252528-rgnhfcbx	28	28	informatic	informatic	JJ
cord-252528-rgnhfcbx	28	29	analysis	analysis	NN
cord-252528-rgnhfcbx	28	30	predicts	predict	VBZ
cord-252528-rgnhfcbx	28	31	a	a	DT
cord-252528-rgnhfcbx	28	32	downregulated	downregulate	VBN
cord-252528-rgnhfcbx	28	33	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	28	34	expression	expression	NN
cord-252528-rgnhfcbx	28	35	in	in	IN
cord-252528-rgnhfcbx	28	36	SARS	SARS	NNP
cord-252528-rgnhfcbx	28	37	-	-	HYPH
cord-252528-rgnhfcbx	28	38	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	28	39	infection	infection	NN
cord-252528-rgnhfcbx	28	40	[	[	-LRB-
cord-252528-rgnhfcbx	28	41	7	7	CD
cord-252528-rgnhfcbx	28	42	]	]	-RRB-
cord-252528-rgnhfcbx	28	43	.	.	.
cord-252528-rgnhfcbx	29	1	By	by	IN
cord-252528-rgnhfcbx	29	2	interpreting	interpret	VBG
cord-252528-rgnhfcbx	29	3	the	the	DT
cord-252528-rgnhfcbx	29	4	antithrombotic	antithrombotic	JJ
cord-252528-rgnhfcbx	29	5	and	and	CC
cord-252528-rgnhfcbx	29	6	anti	anti	JJ
cord-252528-rgnhfcbx	29	7	-	-	JJ
cord-252528-rgnhfcbx	29	8	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	29	9	functions	function	NNS
cord-252528-rgnhfcbx	29	10	of	of	IN
cord-252528-rgnhfcbx	29	11	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	29	12	,	,	,
cord-252528-rgnhfcbx	29	13	we	-PRON-	PRP
cord-252528-rgnhfcbx	29	14	propose	propose	VBP
cord-252528-rgnhfcbx	29	15	that	that	IN
cord-252528-rgnhfcbx	29	16	the	the	DT
cord-252528-rgnhfcbx	29	17	potential	potential	JJ
cord-252528-rgnhfcbx	29	18	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	29	19	down	down	IN
cord-252528-rgnhfcbx	29	20	-	-	HYPH
cord-252528-rgnhfcbx	29	21	regulation	regulation	NN
cord-252528-rgnhfcbx	29	22	in	in	IN
cord-252528-rgnhfcbx	29	23	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	29	24	can	can	MD
cord-252528-rgnhfcbx	29	25	contribute	contribute	VB
cord-252528-rgnhfcbx	29	26	to	to	IN
cord-252528-rgnhfcbx	29	27	the	the	DT
cord-252528-rgnhfcbx	29	28	pathogenesis	pathogenesis	NN
cord-252528-rgnhfcbx	29	29	of	of	IN
cord-252528-rgnhfcbx	29	30	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	29	31	state	state	NN
cord-252528-rgnhfcbx	29	32	and	and	CC
cord-252528-rgnhfcbx	29	33	excessive	excessive	JJ
cord-252528-rgnhfcbx	29	34	inflammation	inflammation	NN
cord-252528-rgnhfcbx	29	35	in	in	IN
cord-252528-rgnhfcbx	29	36	severe	severe	JJ
cord-252528-rgnhfcbx	29	37	cases	case	NNS
cord-252528-rgnhfcbx	29	38	.	.	.
cord-252528-rgnhfcbx	30	1	Moreover	moreover	RB
cord-252528-rgnhfcbx	30	2	,	,	,
cord-252528-rgnhfcbx	30	3	we	-PRON-	PRP
cord-252528-rgnhfcbx	30	4	further	further	RB
cord-252528-rgnhfcbx	30	5	discuss	discuss	VBP
cord-252528-rgnhfcbx	30	6	the	the	DT
cord-252528-rgnhfcbx	30	7	mutually	mutually	RB
cord-252528-rgnhfcbx	30	8	promoting	promote	VBG
cord-252528-rgnhfcbx	30	9	effects	effect	NNS
cord-252528-rgnhfcbx	30	10	of	of	IN
cord-252528-rgnhfcbx	30	11	excessive	excessive	JJ
cord-252528-rgnhfcbx	30	12	cytokine	cytokine	NN
cord-252528-rgnhfcbx	30	13	release	release	NN
cord-252528-rgnhfcbx	30	14	and	and	CC
cord-252528-rgnhfcbx	30	15	potential	potential	JJ
cord-252528-rgnhfcbx	30	16	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	30	17	down	down	NN
cord-252528-rgnhfcbx	30	18	-	-	HYPH
cord-252528-rgnhfcbx	30	19	regulation	regulation	NN
cord-252528-rgnhfcbx	30	20	on	on	IN
cord-252528-rgnhfcbx	30	21	the	the	DT
cord-252528-rgnhfcbx	30	22	pro	pro	JJ
cord-252528-rgnhfcbx	30	23	-	-	JJ
cord-252528-rgnhfcbx	30	24	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	30	25	activities	activity	NNS
cord-252528-rgnhfcbx	30	26	of	of	IN
cord-252528-rgnhfcbx	30	27	each	each	DT
cord-252528-rgnhfcbx	30	28	other	other	JJ
cord-252528-rgnhfcbx	30	29	.	.	.
cord-252528-rgnhfcbx	31	1	Ultimately	ultimately	RB
cord-252528-rgnhfcbx	31	2	,	,	,
cord-252528-rgnhfcbx	31	3	based	base	VBN
cord-252528-rgnhfcbx	31	4	on	on	IN
cord-252528-rgnhfcbx	31	5	previous	previous	JJ
cord-252528-rgnhfcbx	31	6	preclinical	preclinical	JJ
cord-252528-rgnhfcbx	31	7	studies	study	NNS
cord-252528-rgnhfcbx	31	8	and	and	CC
cord-252528-rgnhfcbx	31	9	recent	recent	JJ
cord-252528-rgnhfcbx	31	10	clinical	clinical	JJ
cord-252528-rgnhfcbx	31	11	studies	study	NNS
cord-252528-rgnhfcbx	31	12	,	,	,
cord-252528-rgnhfcbx	31	13	we	-PRON-	PRP
cord-252528-rgnhfcbx	31	14	analyze	analyze	VBP
cord-252528-rgnhfcbx	31	15	the	the	DT
cord-252528-rgnhfcbx	31	16	effects	effect	NNS
cord-252528-rgnhfcbx	31	17	of	of	IN
cord-252528-rgnhfcbx	31	18	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	31	19	-	-	HYPH
cord-252528-rgnhfcbx	31	20	converting	convert	VBG
cord-252528-rgnhfcbx	31	21	enzyme	enzyme	NN
cord-252528-rgnhfcbx	31	22	inhibitors	inhibitor	NNS
cord-252528-rgnhfcbx	31	23	(	(	-LRB-
cord-252528-rgnhfcbx	31	24	ACEIs	acei	NNS
cord-252528-rgnhfcbx	31	25	)	)	-RRB-
cord-252528-rgnhfcbx	31	26	and	and	CC
cord-252528-rgnhfcbx	31	27	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	31	28	II	II	NNP
cord-252528-rgnhfcbx	31	29	receptor	receptor	NN
cord-252528-rgnhfcbx	31	30	blockers	blocker	NNS
cord-252528-rgnhfcbx	31	31	(	(	-LRB-
cord-252528-rgnhfcbx	31	32	ARBs	arb	NNS
cord-252528-rgnhfcbx	31	33	)	)	-RRB-
cord-252528-rgnhfcbx	31	34	treatment	treatment	NN
cord-252528-rgnhfcbx	31	35	on	on	IN
cord-252528-rgnhfcbx	31	36	the	the	DT
cord-252528-rgnhfcbx	31	37	risk	risk	NN
cord-252528-rgnhfcbx	31	38	of	of	IN
cord-252528-rgnhfcbx	31	39	vascular	vascular	JJ
cord-252528-rgnhfcbx	31	40	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	31	41	.	.	.
cord-252528-rgnhfcbx	32	1	By	by	IN
cord-252528-rgnhfcbx	32	2	interpreting	interpret	VBG
cord-252528-rgnhfcbx	32	3	the	the	DT
cord-252528-rgnhfcbx	32	4	pathological	pathological	JJ
cord-252528-rgnhfcbx	32	5	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	32	6	,	,	,
cord-252528-rgnhfcbx	32	7	we	-PRON-	PRP
cord-252528-rgnhfcbx	32	8	aim	aim	VBP
cord-252528-rgnhfcbx	32	9	to	to	TO
cord-252528-rgnhfcbx	32	10	illustrate	illustrate	VB
cord-252528-rgnhfcbx	32	11	that	that	IN
cord-252528-rgnhfcbx	32	12	excessive	excessive	JJ
cord-252528-rgnhfcbx	32	13	pro	pro	JJ
cord-252528-rgnhfcbx	32	14	-	-	JJ
cord-252528-rgnhfcbx	32	15	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	32	16	cytokine	cytokine	NN
cord-252528-rgnhfcbx	32	17	release	release	NN
cord-252528-rgnhfcbx	32	18	and	and	CC
cord-252528-rgnhfcbx	32	19	potential	potential	JJ
cord-252528-rgnhfcbx	32	20	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	32	21	down	down	NN
cord-252528-rgnhfcbx	32	22	-	-	HYPH
cord-252528-rgnhfcbx	32	23	regulation	regulation	NN
cord-252528-rgnhfcbx	32	24	can	can	MD
cord-252528-rgnhfcbx	32	25	promote	promote	VB
cord-252528-rgnhfcbx	32	26	the	the	DT
cord-252528-rgnhfcbx	32	27	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	32	28	state	state	NN
cord-252528-rgnhfcbx	32	29	in	in	IN
cord-252528-rgnhfcbx	32	30	severe	severe	JJ
cord-252528-rgnhfcbx	32	31	COVID-	covid-	NN
cord-252528-rgnhfcbx	32	32	19	19	CD
cord-252528-rgnhfcbx	32	33	,	,	,
cord-252528-rgnhfcbx	32	34	and	and	CC
cord-252528-rgnhfcbx	32	35	propose	propose	VB
cord-252528-rgnhfcbx	32	36	that	that	IN
cord-252528-rgnhfcbx	32	37	the	the	DT
cord-252528-rgnhfcbx	32	38	anti	anti	JJ
cord-252528-rgnhfcbx	32	39	-	-	JJ
cord-252528-rgnhfcbx	32	40	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	32	41	medications	medication	NNS
cord-252528-rgnhfcbx	32	42	,	,	,
cord-252528-rgnhfcbx	32	43	as	as	RB
cord-252528-rgnhfcbx	32	44	well	well	RB
cord-252528-rgnhfcbx	32	45	as	as	IN
cord-252528-rgnhfcbx	32	46	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	32	47	/	/	SYM
cord-252528-rgnhfcbx	32	48	ARB	ARB	NNP
cord-252528-rgnhfcbx	32	49	,	,	,
cord-252528-rgnhfcbx	32	50	can	can	MD
cord-252528-rgnhfcbx	32	51	benefit	benefit	VB
cord-252528-rgnhfcbx	32	52	severe	severe	JJ
cord-252528-rgnhfcbx	32	53	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	32	54	patients	patient	NNS
cord-252528-rgnhfcbx	32	55	by	by	IN
cord-252528-rgnhfcbx	32	56	reducing	reduce	VBG
cord-252528-rgnhfcbx	32	57	the	the	DT
cord-252528-rgnhfcbx	32	58	risk	risk	NN
cord-252528-rgnhfcbx	32	59	of	of	IN
cord-252528-rgnhfcbx	32	60	vascular	vascular	JJ
cord-252528-rgnhfcbx	32	61	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	32	62	events	event	NNS
cord-252528-rgnhfcbx	32	63	.	.	.
cord-252528-rgnhfcbx	33	1	Although	although	IN
cord-252528-rgnhfcbx	33	2	pneumonia	pneumonia	NN
cord-252528-rgnhfcbx	33	3	is	be	VBZ
cord-252528-rgnhfcbx	33	4	the	the	DT
cord-252528-rgnhfcbx	33	5	most	most	RBS
cord-252528-rgnhfcbx	33	6	common	common	JJ
cord-252528-rgnhfcbx	33	7	manifestation	manifestation	NN
cord-252528-rgnhfcbx	33	8	of	of	IN
cord-252528-rgnhfcbx	33	9	severe	severe	JJ
cord-252528-rgnhfcbx	33	10	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	33	11	,	,	,
cord-252528-rgnhfcbx	33	12	recent	recent	JJ
cord-252528-rgnhfcbx	33	13	clinical	clinical	JJ
cord-252528-rgnhfcbx	33	14	studies	study	NNS
cord-252528-rgnhfcbx	33	15	have	have	VBP
cord-252528-rgnhfcbx	33	16	suggested	suggest	VBN
cord-252528-rgnhfcbx	33	17	a	a	DT
cord-252528-rgnhfcbx	33	18	significant	significant	JJ
cord-252528-rgnhfcbx	33	19	association	association	NN
cord-252528-rgnhfcbx	33	20	between	between	IN
cord-252528-rgnhfcbx	33	21	vascular	vascular	JJ
cord-252528-rgnhfcbx	33	22	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	33	23	or	or	CC
cord-252528-rgnhfcbx	33	24	thromboembolic	thromboembolic	JJ
cord-252528-rgnhfcbx	33	25	events	event	NNS
cord-252528-rgnhfcbx	33	26	and	and	CC
cord-252528-rgnhfcbx	33	27	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	33	28	severity	severity	NN
cord-252528-rgnhfcbx	33	29	[	[	-LRB-
cord-252528-rgnhfcbx	33	30	1	1	CD
cord-252528-rgnhfcbx	33	31	,	,	,
cord-252528-rgnhfcbx	33	32	2	2	CD
cord-252528-rgnhfcbx	33	33	,	,	,
cord-252528-rgnhfcbx	33	34	8	8	CD
cord-252528-rgnhfcbx	33	35	]	]	-RRB-
cord-252528-rgnhfcbx	33	36	.	.	.
cord-252528-rgnhfcbx	34	1	In	in	IN
cord-252528-rgnhfcbx	34	2	a	a	DT
cord-252528-rgnhfcbx	34	3	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	34	4	analysis	analysis	NN
cord-252528-rgnhfcbx	34	5	of	of	IN
cord-252528-rgnhfcbx	34	6	183	183	CD
cord-252528-rgnhfcbx	34	7	COVID-19	covid-19	CD
cord-252528-rgnhfcbx	34	8	patients	patient	NNS
cord-252528-rgnhfcbx	34	9	,	,	,
cord-252528-rgnhfcbx	34	10	a	a	DT
cord-252528-rgnhfcbx	34	11	marked	marked	JJ
cord-252528-rgnhfcbx	34	12	increase	increase	NN
cord-252528-rgnhfcbx	34	13	in	in	IN
cord-252528-rgnhfcbx	34	14	serum	serum	NN
cord-252528-rgnhfcbx	34	15	D	d	NN
cord-252528-rgnhfcbx	34	16	-	-	HYPH
cord-252528-rgnhfcbx	34	17	dimer	dimer	NN
cord-252528-rgnhfcbx	34	18	level	level	NN
cord-252528-rgnhfcbx	34	19	,	,	,
cord-252528-rgnhfcbx	34	20	indicating	indicate	VBG
cord-252528-rgnhfcbx	34	21	a	a	DT
cord-252528-rgnhfcbx	34	22	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	34	23	state	state	NN
cord-252528-rgnhfcbx	34	24	,	,	,
cord-252528-rgnhfcbx	34	25	is	be	VBZ
cord-252528-rgnhfcbx	34	26	frequently	frequently	RB
cord-252528-rgnhfcbx	34	27	observed	observe	VBN
cord-252528-rgnhfcbx	34	28	in	in	IN
cord-252528-rgnhfcbx	34	29	non	non	NNS
cord-252528-rgnhfcbx	34	30	-	-	NNS
cord-252528-rgnhfcbx	34	31	survivors	survivor	NNS
cord-252528-rgnhfcbx	34	32	.	.	.
cord-252528-rgnhfcbx	35	1	Disseminated	disseminate	VBN
cord-252528-rgnhfcbx	35	2	intravascular	intravascular	JJ
cord-252528-rgnhfcbx	35	3	coagulation	coagulation	NN
cord-252528-rgnhfcbx	35	4	(	(	-LRB-
cord-252528-rgnhfcbx	35	5	DIC	DIC	NNP
cord-252528-rgnhfcbx	35	6	)	)	-RRB-
cord-252528-rgnhfcbx	35	7	has	have	VBZ
cord-252528-rgnhfcbx	35	8	occurred	occur	VBN
cord-252528-rgnhfcbx	35	9	in	in	IN
cord-252528-rgnhfcbx	35	10	71.4	71.4	CD
cord-252528-rgnhfcbx	35	11	%	%	NN
cord-252528-rgnhfcbx	35	12	of	of	IN
cord-252528-rgnhfcbx	35	13	non	non	NNS
cord-252528-rgnhfcbx	35	14	-	-	NNS
cord-252528-rgnhfcbx	35	15	survivors	survivor	NNS
cord-252528-rgnhfcbx	35	16	,	,	,
cord-252528-rgnhfcbx	35	17	compared	compare	VBN
cord-252528-rgnhfcbx	35	18	to	to	IN
cord-252528-rgnhfcbx	35	19	an	an	DT
cord-252528-rgnhfcbx	35	20	only	only	JJ
cord-252528-rgnhfcbx	35	21	0.6	0.6	CD
cord-252528-rgnhfcbx	35	22	%	%	NN
cord-252528-rgnhfcbx	35	23	chance	chance	NN
cord-252528-rgnhfcbx	35	24	of	of	IN
cord-252528-rgnhfcbx	35	25	DIC	DIC	NNP
cord-252528-rgnhfcbx	35	26	in	in	IN
cord-252528-rgnhfcbx	35	27	patients	patient	NNS
cord-252528-rgnhfcbx	35	28	who	who	WP
cord-252528-rgnhfcbx	35	29	survived	survive	VBD
cord-252528-rgnhfcbx	35	30	[	[	-LRB-
cord-252528-rgnhfcbx	35	31	1	1	CD
cord-252528-rgnhfcbx	35	32	]	]	-RRB-
cord-252528-rgnhfcbx	35	33	.	.	.
cord-252528-rgnhfcbx	36	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	36	2	,	,	,
cord-252528-rgnhfcbx	36	3	a	a	DT
cord-252528-rgnhfcbx	36	4	pooled	pool	VBN
cord-252528-rgnhfcbx	36	5	analysis	analysis	NN
cord-252528-rgnhfcbx	36	6	has	have	VBZ
cord-252528-rgnhfcbx	36	7	further	further	RB
cord-252528-rgnhfcbx	36	8	confirmed	confirm	VBN
cord-252528-rgnhfcbx	36	9	the	the	DT
cord-252528-rgnhfcbx	36	10	association	association	NN
cord-252528-rgnhfcbx	36	11	between	between	IN
cord-252528-rgnhfcbx	36	12	increased	increased	JJ
cord-252528-rgnhfcbx	36	13	serum	serum	NN
cord-252528-rgnhfcbx	36	14	D	d	NN
cord-252528-rgnhfcbx	36	15	-	-	HYPH
cord-252528-rgnhfcbx	36	16	dimer	dimer	NN
cord-252528-rgnhfcbx	36	17	level	level	NN
cord-252528-rgnhfcbx	36	18	and	and	CC
cord-252528-rgnhfcbx	36	19	poor	poor	JJ
cord-252528-rgnhfcbx	36	20	clinical	clinical	JJ
cord-252528-rgnhfcbx	36	21	prognosis	prognosis	NN
cord-252528-rgnhfcbx	36	22	[	[	-LRB-
cord-252528-rgnhfcbx	36	23	9	9	CD
cord-252528-rgnhfcbx	36	24	]	]	-RRB-
cord-252528-rgnhfcbx	36	25	.	.	.
cord-252528-rgnhfcbx	37	1	In	in	IN
cord-252528-rgnhfcbx	37	2	a	a	DT
cord-252528-rgnhfcbx	37	3	recent	recent	JJ
cord-252528-rgnhfcbx	37	4	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	37	5	clinical	clinical	JJ
cord-252528-rgnhfcbx	37	6	case	case	NN
cord-252528-rgnhfcbx	37	7	report	report	NN
cord-252528-rgnhfcbx	37	8	,	,	,
cord-252528-rgnhfcbx	37	9	anti	anti	JJ
cord-252528-rgnhfcbx	37	10	-	-	JJ
cord-252528-rgnhfcbx	37	11	phospholipid	phospholipid	JJ
cord-252528-rgnhfcbx	37	12	antibodies	antibody	NNS
cord-252528-rgnhfcbx	37	13	(	(	-LRB-
cord-252528-rgnhfcbx	37	14	aPL	aPL	NNP
cord-252528-rgnhfcbx	37	15	)	)	-RRB-
cord-252528-rgnhfcbx	37	16	have	have	VBP
cord-252528-rgnhfcbx	37	17	been	be	VBN
cord-252528-rgnhfcbx	37	18	detected	detect	VBN
cord-252528-rgnhfcbx	37	19	in	in	IN
cord-252528-rgnhfcbx	37	20	3	3	CD
cord-252528-rgnhfcbx	37	21	ICU	ICU	NNP
cord-252528-rgnhfcbx	37	22	patients	patient	NNS
cord-252528-rgnhfcbx	37	23	with	with	IN
cord-252528-rgnhfcbx	37	24	multiple	multiple	JJ
cord-252528-rgnhfcbx	37	25	infarcts	infarct	NNS
cord-252528-rgnhfcbx	37	26	,	,	,
cord-252528-rgnhfcbx	37	27	and	and	CC
cord-252528-rgnhfcbx	37	28	anti	anti	JJ
cord-252528-rgnhfcbx	37	29	-	-	JJ
cord-252528-rgnhfcbx	37	30	phospholipid	phospholipid	JJ
cord-252528-rgnhfcbx	37	31	syndrome	syndrome	NN
cord-252528-rgnhfcbx	37	32	(	(	-LRB-
cord-252528-rgnhfcbx	37	33	APS	APS	NNP
cord-252528-rgnhfcbx	37	34	)	)	-RRB-
cord-252528-rgnhfcbx	37	35	is	be	VBZ
cord-252528-rgnhfcbx	37	36	suspected	suspect	VBN
cord-252528-rgnhfcbx	37	37	to	to	TO
cord-252528-rgnhfcbx	37	38	be	be	VB
cord-252528-rgnhfcbx	37	39	a	a	DT
cord-252528-rgnhfcbx	37	40	potential	potential	JJ
cord-252528-rgnhfcbx	37	41	cause	cause	NN
cord-252528-rgnhfcbx	37	42	of	of	IN
cord-252528-rgnhfcbx	37	43	the	the	DT
cord-252528-rgnhfcbx	37	44	vascular	vascular	JJ
cord-252528-rgnhfcbx	37	45	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	37	46	events	event	NNS
cord-252528-rgnhfcbx	37	47	in	in	IN
cord-252528-rgnhfcbx	37	48	these	these	DT
cord-252528-rgnhfcbx	37	49	severe	severe	JJ
cord-252528-rgnhfcbx	37	50	cases	case	NNS
cord-252528-rgnhfcbx	37	51	[	[	-LRB-
cord-252528-rgnhfcbx	37	52	10	10	CD
cord-252528-rgnhfcbx	37	53	]	]	-RRB-
cord-252528-rgnhfcbx	37	54	.	.	.
cord-252528-rgnhfcbx	38	1	As	as	IN
cord-252528-rgnhfcbx	38	2	evidenced	evidence	VBN
cord-252528-rgnhfcbx	38	3	by	by	IN
cord-252528-rgnhfcbx	38	4	previous	previous	JJ
cord-252528-rgnhfcbx	38	5	clinical	clinical	JJ
cord-252528-rgnhfcbx	38	6	studies	study	NNS
cord-252528-rgnhfcbx	38	7	,	,	,
cord-252528-rgnhfcbx	38	8	persistent	persistent	JJ
cord-252528-rgnhfcbx	38	9	positive	positive	JJ
cord-252528-rgnhfcbx	38	10	for	for	IN
cord-252528-rgnhfcbx	38	11	serum	serum	NN
cord-252528-rgnhfcbx	38	12	aPL	aPL	NNP
cord-252528-rgnhfcbx	38	13	is	be	VBZ
cord-252528-rgnhfcbx	38	14	not	not	RB
cord-252528-rgnhfcbx	38	15	necessarily	necessarily	RB
cord-252528-rgnhfcbx	38	16	related	relate	VBN
cord-252528-rgnhfcbx	38	17	to	to	IN
cord-252528-rgnhfcbx	38	18	the	the	DT
cord-252528-rgnhfcbx	38	19	clinical	clinical	JJ
cord-252528-rgnhfcbx	38	20	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	38	21	of	of	IN
cord-252528-rgnhfcbx	38	22	APS	APS	NNP
cord-252528-rgnhfcbx	38	23	,	,	,
cord-252528-rgnhfcbx	38	24	including	include	VBG
cord-252528-rgnhfcbx	38	25	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	38	26	events	event	NNS
cord-252528-rgnhfcbx	38	27	,	,	,
cord-252528-rgnhfcbx	38	28	in	in	IN
cord-252528-rgnhfcbx	38	29	patients	patient	NNS
cord-252528-rgnhfcbx	38	30	with	with	IN
cord-252528-rgnhfcbx	38	31	virus	virus	NN
cord-252528-rgnhfcbx	38	32	infection	infection	NN
cord-252528-rgnhfcbx	38	33	[	[	-LRB-
cord-252528-rgnhfcbx	38	34	11	11	CD
cord-252528-rgnhfcbx	38	35	]	]	-RRB-
cord-252528-rgnhfcbx	38	36	.	.	.
cord-252528-rgnhfcbx	39	1	In	in	IN
cord-252528-rgnhfcbx	39	2	addition	addition	NN
cord-252528-rgnhfcbx	39	3	to	to	IN
cord-252528-rgnhfcbx	39	4	the	the	DT
cord-252528-rgnhfcbx	39	5	increased	increase	VBN
cord-252528-rgnhfcbx	39	6	aPL	aPL	NNP
cord-252528-rgnhfcbx	39	7	,	,	,
cord-252528-rgnhfcbx	39	8	a	a	DT
cord-252528-rgnhfcbx	39	9	second	second	JJ
cord-252528-rgnhfcbx	39	10	thrombophilic	thrombophilic	JJ
cord-252528-rgnhfcbx	39	11	factor	factor	NN
cord-252528-rgnhfcbx	39	12	is	be	VBZ
cord-252528-rgnhfcbx	39	13	necessary	necessary	JJ
cord-252528-rgnhfcbx	39	14	for	for	IN
cord-252528-rgnhfcbx	39	15	the	the	DT
cord-252528-rgnhfcbx	39	16	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	39	17	events	event	NNS
cord-252528-rgnhfcbx	39	18	associated	associate	VBN
cord-252528-rgnhfcbx	39	19	with	with	IN
cord-252528-rgnhfcbx	39	20	APS	APS	NNP
cord-252528-rgnhfcbx	39	21	to	to	TO
cord-252528-rgnhfcbx	39	22	occur	occur	VB
cord-252528-rgnhfcbx	39	23	[	[	-LRB-
cord-252528-rgnhfcbx	39	24	12	12	CD
cord-252528-rgnhfcbx	39	25	]	]	-RRB-
cord-252528-rgnhfcbx	39	26	.	.	.
cord-252528-rgnhfcbx	40	1	Therefore	therefore	RB
cord-252528-rgnhfcbx	40	2	,	,	,
cord-252528-rgnhfcbx	40	3	a	a	DT
cord-252528-rgnhfcbx	40	4	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	40	5	state	state	NN
cord-252528-rgnhfcbx	40	6	might	may	MD
cord-252528-rgnhfcbx	40	7	be	be	VB
cord-252528-rgnhfcbx	40	8	an	an	DT
cord-252528-rgnhfcbx	40	9	essential	essential	JJ
cord-252528-rgnhfcbx	40	10	factor	factor	NN
cord-252528-rgnhfcbx	40	11	that	that	WDT
cord-252528-rgnhfcbx	40	12	synergistically	synergistically	RB
cord-252528-rgnhfcbx	40	13	contributes	contribute	VBZ
cord-252528-rgnhfcbx	40	14	to	to	IN
cord-252528-rgnhfcbx	40	15	the	the	DT
cord-252528-rgnhfcbx	40	16	observed	observed	JJ
cord-252528-rgnhfcbx	40	17	multiple	multiple	JJ
cord-252528-rgnhfcbx	40	18	infarctions	infarction	NNS
cord-252528-rgnhfcbx	40	19	along	along	IN
cord-252528-rgnhfcbx	40	20	with	with	IN
cord-252528-rgnhfcbx	40	21	the	the	DT
cord-252528-rgnhfcbx	40	22	enhanced	enhanced	JJ
cord-252528-rgnhfcbx	40	23	serum	serum	NN
cord-252528-rgnhfcbx	40	24	aPL	apl	NN
cord-252528-rgnhfcbx	40	25	in	in	IN
cord-252528-rgnhfcbx	40	26	the	the	DT
cord-252528-rgnhfcbx	40	27	3	3	CD
cord-252528-rgnhfcbx	40	28	ICU	ICU	NNP
cord-252528-rgnhfcbx	40	29	patients	patient	NNS
cord-252528-rgnhfcbx	40	30	with	with	IN
cord-252528-rgnhfcbx	40	31	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	40	32	.	.	.
cord-252528-rgnhfcbx	41	1	The	the	DT
cord-252528-rgnhfcbx	41	2	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	41	3	state	state	NN
cord-252528-rgnhfcbx	41	4	,	,	,
cord-252528-rgnhfcbx	41	5	manifested	manifest	VBN
cord-252528-rgnhfcbx	41	6	by	by	IN
cord-252528-rgnhfcbx	41	7	the	the	DT
cord-252528-rgnhfcbx	41	8	multiinfarctions	multiinfarction	NNS
cord-252528-rgnhfcbx	41	9	and	and	CC
cord-252528-rgnhfcbx	41	10	the	the	DT
cord-252528-rgnhfcbx	41	11	increased	increase	VBN
cord-252528-rgnhfcbx	41	12	serum	serum	NN
cord-252528-rgnhfcbx	41	13	level	level	NN
cord-252528-rgnhfcbx	41	14	of	of	IN
cord-252528-rgnhfcbx	41	15	D	d	NN
cord-252528-rgnhfcbx	41	16	-	-	HYPH
cord-252528-rgnhfcbx	41	17	dimer	dimer	NN
cord-252528-rgnhfcbx	41	18	,	,	,
cord-252528-rgnhfcbx	41	19	is	be	VBZ
cord-252528-rgnhfcbx	41	20	related	relate	VBN
cord-252528-rgnhfcbx	41	21	to	to	IN
cord-252528-rgnhfcbx	41	22	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	41	23	severity	severity	NN
cord-252528-rgnhfcbx	41	24	and	and	CC
cord-252528-rgnhfcbx	41	25	indicate	indicate	VBP
cord-252528-rgnhfcbx	41	26	a	a	DT
cord-252528-rgnhfcbx	41	27	poor	poor	JJ
cord-252528-rgnhfcbx	41	28	prognosis	prognosis	NN
cord-252528-rgnhfcbx	41	29	.	.	.
cord-252528-rgnhfcbx	42	1	Understanding	understand	VBG
cord-252528-rgnhfcbx	42	2	the	the	DT
cord-252528-rgnhfcbx	42	3	pathophysiology	pathophysiology	NN
cord-252528-rgnhfcbx	42	4	behind	behind	IN
cord-252528-rgnhfcbx	42	5	the	the	DT
cord-252528-rgnhfcbx	42	6	vascular	vascular	JJ
cord-252528-rgnhfcbx	42	7	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	42	8	events	event	NNS
cord-252528-rgnhfcbx	42	9	in	in	IN
cord-252528-rgnhfcbx	42	10	severe	severe	JJ
cord-252528-rgnhfcbx	42	11	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	42	12	is	be	VBZ
cord-252528-rgnhfcbx	42	13	beneficial	beneficial	JJ
cord-252528-rgnhfcbx	42	14	for	for	IN
cord-252528-rgnhfcbx	42	15	the	the	DT
cord-252528-rgnhfcbx	42	16	prevention	prevention	NN
cord-252528-rgnhfcbx	42	17	and	and	CC
cord-252528-rgnhfcbx	42	18	treatment	treatment	NN
cord-252528-rgnhfcbx	42	19	of	of	IN
cord-252528-rgnhfcbx	42	20	these	these	DT
cord-252528-rgnhfcbx	42	21	events	event	NNS
cord-252528-rgnhfcbx	42	22	.	.	.
cord-252528-rgnhfcbx	43	1	A	a	DT
cord-252528-rgnhfcbx	43	2	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	43	3	clinical	clinical	JJ
cord-252528-rgnhfcbx	43	4	study	study	NN
cord-252528-rgnhfcbx	43	5	indicates	indicate	VBZ
cord-252528-rgnhfcbx	43	6	that	that	IN
cord-252528-rgnhfcbx	43	7	,	,	,
cord-252528-rgnhfcbx	43	8	compared	compare	VBN
cord-252528-rgnhfcbx	43	9	to	to	IN
cord-252528-rgnhfcbx	43	10	mild	mild	JJ
cord-252528-rgnhfcbx	43	11	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	43	12	patients	patient	NNS
cord-252528-rgnhfcbx	43	13	,	,	,
cord-252528-rgnhfcbx	43	14	severe	severe	JJ
cord-252528-rgnhfcbx	43	15	patients	patient	NNS
cord-252528-rgnhfcbx	43	16	display	display	VBP
cord-252528-rgnhfcbx	43	17	lower	low	JJR
cord-252528-rgnhfcbx	43	18	levels	level	NNS
cord-252528-rgnhfcbx	43	19	of	of	IN
cord-252528-rgnhfcbx	43	20	CD4	CD4	NNP
cord-252528-rgnhfcbx	43	21	+	+	CC
cord-252528-rgnhfcbx	43	22	T	T	NNP
cord-252528-rgnhfcbx	43	23	cells	cell	NNS
cord-252528-rgnhfcbx	43	24	and	and	CC
cord-252528-rgnhfcbx	43	25	CD8	CD8	NNP
cord-252528-rgnhfcbx	43	26	+	+	CC
cord-252528-rgnhfcbx	43	27	T	T	NNP
cord-252528-rgnhfcbx	43	28	cells	cell	NNS
cord-252528-rgnhfcbx	43	29	,	,	,
cord-252528-rgnhfcbx	43	30	as	as	RB
cord-252528-rgnhfcbx	43	31	well	well	RB
cord-252528-rgnhfcbx	43	32	as	as	IN
cord-252528-rgnhfcbx	43	33	higher	high	JJR
cord-252528-rgnhfcbx	43	34	levels	level	NNS
cord-252528-rgnhfcbx	43	35	of	of	IN
cord-252528-rgnhfcbx	43	36	interleukin-6	interleukin-6	NNP
cord-252528-rgnhfcbx	43	37	(	(	-LRB-
cord-252528-rgnhfcbx	43	38	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	43	39	)	)	-RRB-
cord-252528-rgnhfcbx	43	40	and	and	CC
cord-252528-rgnhfcbx	43	41	interleukin-10	interleukin-10	FW
cord-252528-rgnhfcbx	43	42	(	(	-LRB-
cord-252528-rgnhfcbx	43	43	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	43	44	)	)	-RRB-
cord-252528-rgnhfcbx	43	45	in	in	IN
cord-252528-rgnhfcbx	43	46	the	the	DT
cord-252528-rgnhfcbx	43	47	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	43	48	blood	blood	NN
cord-252528-rgnhfcbx	43	49	before	before	IN
cord-252528-rgnhfcbx	43	50	receiving	receive	VBG
cord-252528-rgnhfcbx	43	51	any	any	DT
cord-252528-rgnhfcbx	43	52	treatment	treatment	NN
cord-252528-rgnhfcbx	43	53	for	for	IN
cord-252528-rgnhfcbx	43	54	the	the	DT
cord-252528-rgnhfcbx	43	55	disease	disease	NN
cord-252528-rgnhfcbx	43	56	.	.	.
cord-252528-rgnhfcbx	44	1	No	no	DT
cord-252528-rgnhfcbx	44	2	significant	significant	JJ
cord-252528-rgnhfcbx	44	3	difference	difference	NN
cord-252528-rgnhfcbx	44	4	is	be	VBZ
cord-252528-rgnhfcbx	44	5	found	find	VBN
cord-252528-rgnhfcbx	44	6	in	in	IN
cord-252528-rgnhfcbx	44	7	the	the	DT
cord-252528-rgnhfcbx	44	8	T	T	NNP
cord-252528-rgnhfcbx	44	9	cellpolarizing	cellpolarizing	NNP
cord-252528-rgnhfcbx	44	10	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	44	11	,	,	,
cord-252528-rgnhfcbx	44	12	including	include	VBG
cord-252528-rgnhfcbx	44	13	interleukin-17	interleukin-17	NN
cord-252528-rgnhfcbx	44	14	(	(	-LRB-
cord-252528-rgnhfcbx	44	15	IL-17	IL-17	NNP
cord-252528-rgnhfcbx	44	16	)	)	-RRB-
cord-252528-rgnhfcbx	44	17	,	,	,
cord-252528-rgnhfcbx	44	18	interferon	interferon	NN
cord-252528-rgnhfcbx	44	19	γ	γ	NN
cord-252528-rgnhfcbx	44	20	(	(	-LRB-
cord-252528-rgnhfcbx	44	21	IFN	IFN	NNP
cord-252528-rgnhfcbx	44	22	-	-	HYPH
cord-252528-rgnhfcbx	44	23	γ	γ	NNP
cord-252528-rgnhfcbx	44	24	)	)	-RRB-
cord-252528-rgnhfcbx	44	25	,	,	,
cord-252528-rgnhfcbx	44	26	and	and	CC
cord-252528-rgnhfcbx	44	27	interleukin-4	interleukin-4	NNP
cord-252528-rgnhfcbx	44	28	(	(	-LRB-
cord-252528-rgnhfcbx	44	29	IL-4	IL-4	NNP
cord-252528-rgnhfcbx	44	30	)	)	-RRB-
cord-252528-rgnhfcbx	44	31	,	,	,
cord-252528-rgnhfcbx	44	32	responsible	responsible	JJ
cord-252528-rgnhfcbx	44	33	for	for	IN
cord-252528-rgnhfcbx	44	34	the	the	DT
cord-252528-rgnhfcbx	44	35	polarization	polarization	NN
cord-252528-rgnhfcbx	44	36	of	of	IN
cord-252528-rgnhfcbx	44	37	T	T	NNP
cord-252528-rgnhfcbx	44	38	helper	helper	NN
cord-252528-rgnhfcbx	44	39	cell	cell	NN
cord-252528-rgnhfcbx	44	40	(	(	-LRB-
cord-252528-rgnhfcbx	44	41	Th	Th	NNP
cord-252528-rgnhfcbx	44	42	)	)	-RRB-
cord-252528-rgnhfcbx	44	43	17	17	CD
cord-252528-rgnhfcbx	44	44	,	,	,
cord-252528-rgnhfcbx	44	45	Th1	th1	CD
cord-252528-rgnhfcbx	44	46	,	,	,
cord-252528-rgnhfcbx	44	47	and	and	CC
cord-252528-rgnhfcbx	44	48	Th2	Th2	NNP
cord-252528-rgnhfcbx	44	49	,	,	,
cord-252528-rgnhfcbx	44	50	respectively	respectively	RB
cord-252528-rgnhfcbx	44	51	[	[	-LRB-
cord-252528-rgnhfcbx	44	52	3	3	CD
cord-252528-rgnhfcbx	44	53	]	]	-RRB-
cord-252528-rgnhfcbx	44	54	.	.	.
cord-252528-rgnhfcbx	45	1	However	however	RB
cord-252528-rgnhfcbx	45	2	,	,	,
cord-252528-rgnhfcbx	45	3	compared	compare	VBN
cord-252528-rgnhfcbx	45	4	to	to	IN
cord-252528-rgnhfcbx	45	5	healthy	healthy	JJ
cord-252528-rgnhfcbx	45	6	individuals	individual	NNS
cord-252528-rgnhfcbx	45	7	,	,	,
cord-252528-rgnhfcbx	45	8	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	45	9	patients	patient	NNS
cord-252528-rgnhfcbx	45	10	have	have	VBP
cord-252528-rgnhfcbx	45	11	displayed	display	VBN
cord-252528-rgnhfcbx	45	12	elevation	elevation	NN
cord-252528-rgnhfcbx	45	13	of	of	IN
cord-252528-rgnhfcbx	45	14	serum	serum	NN
cord-252528-rgnhfcbx	45	15	levels	level	NNS
cord-252528-rgnhfcbx	45	16	of	of	IN
cord-252528-rgnhfcbx	45	17	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	45	18	that	that	WDT
cord-252528-rgnhfcbx	45	19	are	be	VBP
cord-252528-rgnhfcbx	45	20	suggestive	suggestive	JJ
cord-252528-rgnhfcbx	45	21	of	of	IN
cord-252528-rgnhfcbx	45	22	pro	pro	JJ
cord-252528-rgnhfcbx	45	23	-	-	JJ
cord-252528-rgnhfcbx	45	24	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	45	25	Th1	th1	CD
cord-252528-rgnhfcbx	45	26	activation	activation	NN
cord-252528-rgnhfcbx	45	27	,	,	,
cord-252528-rgnhfcbx	45	28	including	include	VBG
cord-252528-rgnhfcbx	45	29	IFN	IFN	NNP
cord-252528-rgnhfcbx	45	30	-	-	HYPH
cord-252528-rgnhfcbx	45	31	γ	γ	NNP
cord-252528-rgnhfcbx	45	32	and	and	CC
cord-252528-rgnhfcbx	45	33	IFN	IFN	NNP
cord-252528-rgnhfcbx	45	34	-	-	HYPH
cord-252528-rgnhfcbx	45	35	γ	γ	NNP
cord-252528-rgnhfcbx	45	36	inducible	inducible	JJ
cord-252528-rgnhfcbx	45	37	protein	protein	NN
cord-252528-rgnhfcbx	45	38	10	10	CD
cord-252528-rgnhfcbx	45	39	(	(	-LRB-
cord-252528-rgnhfcbx	45	40	IP-10	IP-10	NNP
cord-252528-rgnhfcbx	45	41	)	)	-RRB-
cord-252528-rgnhfcbx	45	42	.	.	.
cord-252528-rgnhfcbx	46	1	Besides	besides	IN
cord-252528-rgnhfcbx	46	2	the	the	DT
cord-252528-rgnhfcbx	46	3	enhanced	enhance	VBN
cord-252528-rgnhfcbx	46	4	levels	level	NNS
cord-252528-rgnhfcbx	46	5	of	of	IN
cord-252528-rgnhfcbx	46	6	pro	pro	JJ
cord-252528-rgnhfcbx	46	7	-	-	JJ
cord-252528-rgnhfcbx	46	8	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	46	9	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	46	10	,	,	,
cord-252528-rgnhfcbx	46	11	increased	increase	VBN
cord-252528-rgnhfcbx	46	12	plasma	plasma	NN
cord-252528-rgnhfcbx	46	13	levels	level	NNS
cord-252528-rgnhfcbx	46	14	of	of	IN
cord-252528-rgnhfcbx	46	15	anti	anti	JJ
cord-252528-rgnhfcbx	46	16	-	-	JJ
cord-252528-rgnhfcbx	46	17	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	46	18	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	46	19	,	,	,
cord-252528-rgnhfcbx	46	20	including	include	VBG
cord-252528-rgnhfcbx	46	21	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	46	22	,	,	,
cord-252528-rgnhfcbx	46	23	have	have	VBP
cord-252528-rgnhfcbx	46	24	been	be	VBN
cord-252528-rgnhfcbx	46	25	simultaneously	simultaneously	RB
cord-252528-rgnhfcbx	46	26	detected	detect	VBN
cord-252528-rgnhfcbx	46	27	in	in	IN
cord-252528-rgnhfcbx	46	28	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	46	29	patients	patient	NNS
cord-252528-rgnhfcbx	46	30	,	,	,
cord-252528-rgnhfcbx	46	31	suggesting	suggest	VBG
cord-252528-rgnhfcbx	46	32	a	a	DT
cord-252528-rgnhfcbx	46	33	dysregulation	dysregulation	NN
cord-252528-rgnhfcbx	46	34	of	of	IN
cord-252528-rgnhfcbx	46	35	the	the	DT
cord-252528-rgnhfcbx	46	36	adaptive	adaptive	JJ
cord-252528-rgnhfcbx	46	37	immune	immune	JJ
cord-252528-rgnhfcbx	46	38	system	system	NN
cord-252528-rgnhfcbx	46	39	following	follow	VBG
cord-252528-rgnhfcbx	46	40	the	the	DT
cord-252528-rgnhfcbx	46	41	virus	virus	NN
cord-252528-rgnhfcbx	46	42	infection	infection	NN
cord-252528-rgnhfcbx	46	43	[	[	-LRB-
cord-252528-rgnhfcbx	46	44	2	2	CD
cord-252528-rgnhfcbx	46	45	]	]	-RRB-
cord-252528-rgnhfcbx	46	46	.	.	.
cord-252528-rgnhfcbx	47	1	Although	although	IN
cord-252528-rgnhfcbx	47	2	the	the	DT
cord-252528-rgnhfcbx	47	3	mechanism	mechanism	NN
cord-252528-rgnhfcbx	47	4	underlying	underlie	VBG
cord-252528-rgnhfcbx	47	5	the	the	DT
cord-252528-rgnhfcbx	47	6	dysregulated	dysregulate	VBN
cord-252528-rgnhfcbx	47	7	immune	immune	JJ
cord-252528-rgnhfcbx	47	8	response	response	NN
cord-252528-rgnhfcbx	47	9	in	in	IN
cord-252528-rgnhfcbx	47	10	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	47	11	is	be	VBZ
cord-252528-rgnhfcbx	47	12	by	by	IN
cord-252528-rgnhfcbx	47	13	far	far	RB
cord-252528-rgnhfcbx	47	14	beyond	beyond	IN
cord-252528-rgnhfcbx	47	15	comprehension	comprehension	NN
cord-252528-rgnhfcbx	47	16	,	,	,
cord-252528-rgnhfcbx	47	17	clinical	clinical	JJ
cord-252528-rgnhfcbx	47	18	studies	study	NNS
cord-252528-rgnhfcbx	47	19	have	have	VBP
cord-252528-rgnhfcbx	47	20	shown	show	VBN
cord-252528-rgnhfcbx	47	21	that	that	DT
cord-252528-rgnhfcbx	47	22	,	,	,
cord-252528-rgnhfcbx	47	23	both	both	DT
cord-252528-rgnhfcbx	47	24	declined	decline	VBD
cord-252528-rgnhfcbx	47	25	levels	level	NNS
cord-252528-rgnhfcbx	47	26	of	of	IN
cord-252528-rgnhfcbx	47	27	innate	innate	JJ
cord-252528-rgnhfcbx	47	28	and	and	CC
cord-252528-rgnhfcbx	47	29	adaptive	adaptive	JJ
cord-252528-rgnhfcbx	47	30	lymphoid	lymphoid	JJ
cord-252528-rgnhfcbx	47	31	cell	cell	NN
cord-252528-rgnhfcbx	47	32	,	,	,
cord-252528-rgnhfcbx	47	33	and	and	CC
cord-252528-rgnhfcbx	47	34	an	an	DT
cord-252528-rgnhfcbx	47	35	increase	increase	NN
cord-252528-rgnhfcbx	47	36	in	in	IN
cord-252528-rgnhfcbx	47	37	the	the	DT
cord-252528-rgnhfcbx	47	38	percentage	percentage	NN
cord-252528-rgnhfcbx	47	39	of	of	IN
cord-252528-rgnhfcbx	47	40	naïve	naïve	JJ
cord-252528-rgnhfcbx	47	41	CD4	CD4	NNP
cord-252528-rgnhfcbx	47	42	+	+	CC
cord-252528-rgnhfcbx	47	43	T	t	NN
cord-252528-rgnhfcbx	47	44	cells	cell	NNS
cord-252528-rgnhfcbx	47	45	accompanied	accompany	VBN
cord-252528-rgnhfcbx	47	46	by	by	IN
cord-252528-rgnhfcbx	47	47	a	a	DT
cord-252528-rgnhfcbx	47	48	reduction	reduction	NN
cord-252528-rgnhfcbx	47	49	in	in	IN
cord-252528-rgnhfcbx	47	50	the	the	DT
cord-252528-rgnhfcbx	47	51	percentage	percentage	NN
cord-252528-rgnhfcbx	47	52	of	of	IN
cord-252528-rgnhfcbx	47	53	memory	memory	NN
cord-252528-rgnhfcbx	47	54	CD4	CD4	NNP
cord-252528-rgnhfcbx	47	55	+	+	CC
cord-252528-rgnhfcbx	47	56	cells	cell	NNS
cord-252528-rgnhfcbx	47	57	,	,	,
cord-252528-rgnhfcbx	47	58	are	be	VBP
cord-252528-rgnhfcbx	47	59	associated	associate	VBN
cord-252528-rgnhfcbx	47	60	with	with	IN
cord-252528-rgnhfcbx	47	61	SARS	SARS	NNP
cord-252528-rgnhfcbx	47	62	-	-	HYPH
cord-252528-rgnhfcbx	47	63	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	47	64	infection	infection	NN
cord-252528-rgnhfcbx	47	65	,	,	,
cord-252528-rgnhfcbx	47	66	indicating	indicate	VBG
cord-252528-rgnhfcbx	47	67	a	a	DT
cord-252528-rgnhfcbx	47	68	reduced	reduce	VBN
cord-252528-rgnhfcbx	47	69	efficacy	efficacy	NN
cord-252528-rgnhfcbx	47	70	for	for	IN
cord-252528-rgnhfcbx	47	71	virus	virus	NN
cord-252528-rgnhfcbx	47	72	clearance	clearance	NN
cord-252528-rgnhfcbx	47	73	in	in	IN
cord-252528-rgnhfcbx	47	74	infected	infected	JJ
cord-252528-rgnhfcbx	47	75	patients	patient	NNS
cord-252528-rgnhfcbx	47	76	[	[	-LRB-
cord-252528-rgnhfcbx	47	77	13	13	CD
cord-252528-rgnhfcbx	47	78	,	,	,
cord-252528-rgnhfcbx	47	79	14	14	CD
cord-252528-rgnhfcbx	47	80	]	]	-RRB-
cord-252528-rgnhfcbx	47	81	.	.	.
cord-252528-rgnhfcbx	48	1	Thus	thus	RB
cord-252528-rgnhfcbx	48	2	,	,	,
cord-252528-rgnhfcbx	48	3	dysregulated	dysregulate	VBN
cord-252528-rgnhfcbx	48	4	T	t	NN
cord-252528-rgnhfcbx	48	5	cell	cell	NN
cord-252528-rgnhfcbx	48	6	immune	immune	JJ
cord-252528-rgnhfcbx	48	7	responses	response	NNS
cord-252528-rgnhfcbx	48	8	are	be	VBP
cord-252528-rgnhfcbx	48	9	observed	observe	VBN
cord-252528-rgnhfcbx	48	10	in	in	IN
cord-252528-rgnhfcbx	48	11	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	48	12	,	,	,
cord-252528-rgnhfcbx	48	13	potentially	potentially	RB
cord-252528-rgnhfcbx	48	14	contributing	contribute	VBG
cord-252528-rgnhfcbx	48	15	to	to	IN
cord-252528-rgnhfcbx	48	16	the	the	DT
cord-252528-rgnhfcbx	48	17	commonly	commonly	RB
cord-252528-rgnhfcbx	48	18	seen	see	VBN
cord-252528-rgnhfcbx	48	19	lymphocytopenia	lymphocytopenia	NNP
cord-252528-rgnhfcbx	48	20	in	in	IN
cord-252528-rgnhfcbx	48	21	infected	infected	JJ
cord-252528-rgnhfcbx	48	22	patients	patient	NNS
cord-252528-rgnhfcbx	48	23	,	,	,
cord-252528-rgnhfcbx	48	24	leading	lead	VBG
cord-252528-rgnhfcbx	48	25	to	to	IN
cord-252528-rgnhfcbx	48	26	inefficient	inefficient	JJ
cord-252528-rgnhfcbx	48	27	clearance	clearance	NN
cord-252528-rgnhfcbx	48	28	of	of	IN
cord-252528-rgnhfcbx	48	29	the	the	DT
cord-252528-rgnhfcbx	48	30	virus	virus	NN
cord-252528-rgnhfcbx	48	31	[	[	-LRB-
cord-252528-rgnhfcbx	48	32	2	2	CD
cord-252528-rgnhfcbx	48	33	,	,	,
cord-252528-rgnhfcbx	48	34	15	15	CD
cord-252528-rgnhfcbx	48	35	]	]	-RRB-
cord-252528-rgnhfcbx	48	36	.	.	.
cord-252528-rgnhfcbx	49	1	Previous	previous	JJ
cord-252528-rgnhfcbx	49	2	animal	animal	NN
cord-252528-rgnhfcbx	49	3	experiments	experiment	NNS
cord-252528-rgnhfcbx	49	4	using	use	VBG
cord-252528-rgnhfcbx	49	5	mouse	mouse	NN
cord-252528-rgnhfcbx	49	6	models	model	NNS
cord-252528-rgnhfcbx	49	7	with	with	IN
cord-252528-rgnhfcbx	49	8	MERS	MERS	NNP
cord-252528-rgnhfcbx	49	9	(	(	-LRB-
cord-252528-rgnhfcbx	49	10	Middle	Middle	NNP
cord-252528-rgnhfcbx	49	11	East	East	NNP
cord-252528-rgnhfcbx	49	12	respiratory	respiratory	JJ
cord-252528-rgnhfcbx	49	13	syndrome	syndrome	NN
cord-252528-rgnhfcbx	49	14	)	)	-RRB-
cord-252528-rgnhfcbx	49	15	and	and	CC
cord-252528-rgnhfcbx	49	16	SARS	SARS	NNP
cord-252528-rgnhfcbx	49	17	-	-	HYPH
cord-252528-rgnhfcbx	49	18	CoV	CoV	NNP
cord-252528-rgnhfcbx	49	19	(	(	-LRB-
cord-252528-rgnhfcbx	49	20	severe	severe	JJ
cord-252528-rgnhfcbx	49	21	acute	acute	JJ
cord-252528-rgnhfcbx	49	22	respiratory	respiratory	JJ
cord-252528-rgnhfcbx	49	23	syndrome	syndrome	NN
cord-252528-rgnhfcbx	49	24	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	49	25	)	)	-RRB-
cord-252528-rgnhfcbx	49	26	infections	infection	NNS
cord-252528-rgnhfcbx	49	27	have	have	VBP
cord-252528-rgnhfcbx	49	28	shown	show	VBN
cord-252528-rgnhfcbx	49	29	that	that	IN
cord-252528-rgnhfcbx	49	30	the	the	DT
cord-252528-rgnhfcbx	49	31	timing	timing	NN
cord-252528-rgnhfcbx	49	32	of	of	IN
cord-252528-rgnhfcbx	49	33	immune	immune	JJ
cord-252528-rgnhfcbx	49	34	response	response	NN
cord-252528-rgnhfcbx	49	35	in	in	IN
cord-252528-rgnhfcbx	49	36	the	the	DT
cord-252528-rgnhfcbx	49	37	virus	virus	NN
cord-252528-rgnhfcbx	49	38	infections	infection	NNS
cord-252528-rgnhfcbx	49	39	is	be	VBZ
cord-252528-rgnhfcbx	49	40	critical	critical	JJ
cord-252528-rgnhfcbx	49	41	for	for	IN
cord-252528-rgnhfcbx	49	42	optimal	optimal	JJ
cord-252528-rgnhfcbx	49	43	virus	virus	NN
cord-252528-rgnhfcbx	49	44	clearance	clearance	NN
cord-252528-rgnhfcbx	49	45	:	:	:
cord-252528-rgnhfcbx	49	46	an	an	DT
cord-252528-rgnhfcbx	49	47	early	early	JJ
cord-252528-rgnhfcbx	49	48	anti	anti	JJ
cord-252528-rgnhfcbx	49	49	-	-	JJ
cord-252528-rgnhfcbx	49	50	viral	viral	JJ
cord-252528-rgnhfcbx	49	51	response	response	NN
cord-252528-rgnhfcbx	49	52	before	before	IN
cord-252528-rgnhfcbx	49	53	the	the	DT
cord-252528-rgnhfcbx	49	54	peak	peak	NN
cord-252528-rgnhfcbx	49	55	of	of	IN
cord-252528-rgnhfcbx	49	56	virus	virus	NN
cord-252528-rgnhfcbx	49	57	replication	replication	NN
cord-252528-rgnhfcbx	49	58	after	after	IN
cord-252528-rgnhfcbx	49	59	an	an	DT
cord-252528-rgnhfcbx	49	60	infection	infection	NN
cord-252528-rgnhfcbx	49	61	is	be	VBZ
cord-252528-rgnhfcbx	49	62	important	important	JJ
cord-252528-rgnhfcbx	49	63	for	for	IN
cord-252528-rgnhfcbx	49	64	the	the	DT
cord-252528-rgnhfcbx	49	65	inhibition	inhibition	NN
cord-252528-rgnhfcbx	49	66	of	of	IN
cord-252528-rgnhfcbx	49	67	virus	virus	NN
cord-252528-rgnhfcbx	49	68	replication	replication	NN
cord-252528-rgnhfcbx	49	69	and	and	CC
cord-252528-rgnhfcbx	49	70	the	the	DT
cord-252528-rgnhfcbx	49	71	activation	activation	NN
cord-252528-rgnhfcbx	49	72	of	of	IN
cord-252528-rgnhfcbx	49	73	anti	anti	JJ
cord-252528-rgnhfcbx	49	74	-	-	JJ
cord-252528-rgnhfcbx	49	75	viral	viral	JJ
cord-252528-rgnhfcbx	49	76	adaptive	adaptive	JJ
cord-252528-rgnhfcbx	49	77	immune	immune	JJ
cord-252528-rgnhfcbx	49	78	responses	response	NNS
cord-252528-rgnhfcbx	49	79	;	;	:
cord-252528-rgnhfcbx	49	80	however	however	RB
cord-252528-rgnhfcbx	49	81	,	,	,
cord-252528-rgnhfcbx	49	82	a	a	DT
cord-252528-rgnhfcbx	49	83	delayed	delay	VBN
cord-252528-rgnhfcbx	49	84	immune	immune	JJ
cord-252528-rgnhfcbx	49	85	response	response	NN
cord-252528-rgnhfcbx	49	86	to	to	IN
cord-252528-rgnhfcbx	49	87	the	the	DT
cord-252528-rgnhfcbx	49	88	virus	virus	NN
cord-252528-rgnhfcbx	49	89	infection	infection	NN
cord-252528-rgnhfcbx	49	90	not	not	RB
cord-252528-rgnhfcbx	49	91	only	only	RB
cord-252528-rgnhfcbx	49	92	inhibits	inhibit	VBZ
cord-252528-rgnhfcbx	49	93	the	the	DT
cord-252528-rgnhfcbx	49	94	virus	virus	NN
cord-252528-rgnhfcbx	49	95	specific	specific	JJ
cord-252528-rgnhfcbx	49	96	adaptive	adaptive	JJ
cord-252528-rgnhfcbx	49	97	immune	immune	JJ
cord-252528-rgnhfcbx	49	98	responses	response	NNS
cord-252528-rgnhfcbx	49	99	,	,	,
cord-252528-rgnhfcbx	49	100	but	but	CC
cord-252528-rgnhfcbx	49	101	also	also	RB
cord-252528-rgnhfcbx	49	102	enhances	enhance	VBZ
cord-252528-rgnhfcbx	49	103	the	the	DT
cord-252528-rgnhfcbx	49	104	excessive	excessive	JJ
cord-252528-rgnhfcbx	49	105	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	49	106	cytokine	cytokine	NN
cord-252528-rgnhfcbx	49	107	release	release	NN
cord-252528-rgnhfcbx	49	108	and	and	CC
cord-252528-rgnhfcbx	49	109	the	the	DT
cord-252528-rgnhfcbx	49	110	leukocyte	leukocyte	NN
cord-252528-rgnhfcbx	49	111	infiltrations	infiltration	NNS
cord-252528-rgnhfcbx	49	112	into	into	IN
cord-252528-rgnhfcbx	49	113	tissues	tissue	NNS
cord-252528-rgnhfcbx	49	114	or	or	CC
cord-252528-rgnhfcbx	49	115	organs	organ	NNS
cord-252528-rgnhfcbx	49	116	,	,	,
cord-252528-rgnhfcbx	49	117	leading	lead	VBG
cord-252528-rgnhfcbx	49	118	to	to	IN
cord-252528-rgnhfcbx	49	119	a	a	DT
cord-252528-rgnhfcbx	49	120	poor	poor	JJ
cord-252528-rgnhfcbx	49	121	disease	disease	NN
cord-252528-rgnhfcbx	49	122	outcome	outcome	NN
cord-252528-rgnhfcbx	49	123	[	[	-LRB-
cord-252528-rgnhfcbx	49	124	16	16	CD
cord-252528-rgnhfcbx	49	125	,	,	,
cord-252528-rgnhfcbx	49	126	17	17	CD
cord-252528-rgnhfcbx	49	127	]	]	-RRB-
cord-252528-rgnhfcbx	49	128	.	.	.
cord-252528-rgnhfcbx	50	1	Therefore	therefore	RB
cord-252528-rgnhfcbx	50	2	,	,	,
cord-252528-rgnhfcbx	50	3	ineffective	ineffective	JJ
cord-252528-rgnhfcbx	50	4	clearance	clearance	NN
cord-252528-rgnhfcbx	50	5	of	of	IN
cord-252528-rgnhfcbx	50	6	SARS	SARS	NNP
cord-252528-rgnhfcbx	50	7	-	-	HYPH
cord-252528-rgnhfcbx	50	8	CoV2	CoV2	NNP
cord-252528-rgnhfcbx	50	9	following	follow	VBG
cord-252528-rgnhfcbx	50	10	its	-PRON-	PRP$
cord-252528-rgnhfcbx	50	11	infection	infection	NN
cord-252528-rgnhfcbx	50	12	can	can	MD
cord-252528-rgnhfcbx	50	13	lead	lead	VB
cord-252528-rgnhfcbx	50	14	to	to	IN
cord-252528-rgnhfcbx	50	15	a	a	DT
cord-252528-rgnhfcbx	50	16	delayed	delay	VBN
cord-252528-rgnhfcbx	50	17	immune	immune	JJ
cord-252528-rgnhfcbx	50	18	response	response	NN
cord-252528-rgnhfcbx	50	19	,	,	,
cord-252528-rgnhfcbx	50	20	which	which	WDT
cord-252528-rgnhfcbx	50	21	can	can	MD
cord-252528-rgnhfcbx	50	22	bring	bring	VB
cord-252528-rgnhfcbx	50	23	about	about	RP
cord-252528-rgnhfcbx	50	24	continuous	continuous	JJ
cord-252528-rgnhfcbx	50	25	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	50	26	and	and	CC
cord-252528-rgnhfcbx	50	27	excessive	excessive	JJ
cord-252528-rgnhfcbx	50	28	cytokine	cytokine	NN
cord-252528-rgnhfcbx	50	29	release	release	NN
cord-252528-rgnhfcbx	50	30	.	.	.
cord-252528-rgnhfcbx	51	1	According	accord	VBG
cord-252528-rgnhfcbx	51	2	to	to	IN
cord-252528-rgnhfcbx	51	3	the	the	DT
cord-252528-rgnhfcbx	51	4	result	result	NN
cord-252528-rgnhfcbx	51	5	of	of	IN
cord-252528-rgnhfcbx	51	6	a	a	DT
cord-252528-rgnhfcbx	51	7	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	51	8	clinical	clinical	JJ
cord-252528-rgnhfcbx	51	9	study	study	NN
cord-252528-rgnhfcbx	51	10	,	,	,
cord-252528-rgnhfcbx	51	11	excessive	excessive	JJ
cord-252528-rgnhfcbx	51	12	cytokine	cytokine	NN
cord-252528-rgnhfcbx	51	13	release	release	NN
cord-252528-rgnhfcbx	51	14	has	have	VBZ
cord-252528-rgnhfcbx	51	15	occurred	occur	VBN
cord-252528-rgnhfcbx	51	16	in	in	IN
cord-252528-rgnhfcbx	51	17	severe	severe	JJ
cord-252528-rgnhfcbx	51	18	patients	patient	NNS
cord-252528-rgnhfcbx	51	19	with	with	IN
cord-252528-rgnhfcbx	51	20	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	51	21	.	.	.
cord-252528-rgnhfcbx	52	1	Among	among	IN
cord-252528-rgnhfcbx	52	2	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	52	3	patients	patient	NNS
cord-252528-rgnhfcbx	52	4	,	,	,
cord-252528-rgnhfcbx	52	5	intensive	intensive	JJ
cord-252528-rgnhfcbx	52	6	care	care	NN
cord-252528-rgnhfcbx	52	7	unit	unit	NN
cord-252528-rgnhfcbx	52	8	(	(	-LRB-
cord-252528-rgnhfcbx	52	9	ICU	ICU	NNP
cord-252528-rgnhfcbx	52	10	)	)	-RRB-
cord-252528-rgnhfcbx	52	11	patients	patient	NNS
cord-252528-rgnhfcbx	52	12	(	(	-LRB-
cord-252528-rgnhfcbx	52	13	n	n	NN
cord-252528-rgnhfcbx	52	14	=	=	SYM
cord-252528-rgnhfcbx	52	15	13	13	CD
cord-252528-rgnhfcbx	52	16	)	)	-RRB-
cord-252528-rgnhfcbx	52	17	have	have	VBP
cord-252528-rgnhfcbx	52	18	higher	high	JJR
cord-252528-rgnhfcbx	52	19	serum	serum	NN
cord-252528-rgnhfcbx	52	20	levels	level	NNS
cord-252528-rgnhfcbx	52	21	of	of	IN
cord-252528-rgnhfcbx	52	22	interleukin-2	interleukin-2	IN
cord-252528-rgnhfcbx	52	23	(	(	-LRB-
cord-252528-rgnhfcbx	52	24	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	52	25	)	)	-RRB-
cord-252528-rgnhfcbx	52	26	,	,	,
cord-252528-rgnhfcbx	52	27	interleukin-7	interleukin-7	NNP
cord-252528-rgnhfcbx	52	28	(	(	-LRB-
cord-252528-rgnhfcbx	52	29	IL-7	IL-7	NNP
cord-252528-rgnhfcbx	52	30	)	)	-RRB-
cord-252528-rgnhfcbx	52	31	,	,	,
cord-252528-rgnhfcbx	52	32	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	52	33	,	,	,
cord-252528-rgnhfcbx	52	34	granulocytecolony	granulocytecolony	NN
cord-252528-rgnhfcbx	52	35	stimulating	stimulate	VBG
cord-252528-rgnhfcbx	52	36	factor	factor	NN
cord-252528-rgnhfcbx	52	37	(	(	-LRB-
cord-252528-rgnhfcbx	52	38	G	G	NNP
cord-252528-rgnhfcbx	52	39	-	-	HYPH
cord-252528-rgnhfcbx	52	40	CSF	CSF	NNP
cord-252528-rgnhfcbx	52	41	)	)	-RRB-
cord-252528-rgnhfcbx	52	42	,	,	,
cord-252528-rgnhfcbx	52	43	IP-10	IP-10	NNP
cord-252528-rgnhfcbx	52	44	,	,	,
cord-252528-rgnhfcbx	52	45	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	52	46	chemoattractant	chemoattractant	NNP
cord-252528-rgnhfcbx	52	47	protein-1	protein-1	NNP
cord-252528-rgnhfcbx	52	48	(	(	-LRB-
cord-252528-rgnhfcbx	52	49	MCP-1	MCP-1	NNP
cord-252528-rgnhfcbx	52	50	)	)	-RRB-
cord-252528-rgnhfcbx	53	1	,	,	,
cord-252528-rgnhfcbx	53	2	macrophage	macrophage	NN
cord-252528-rgnhfcbx	53	3	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	53	4	protein	protein	NN
cord-252528-rgnhfcbx	54	1	1-α	1-α	CD
cord-252528-rgnhfcbx	54	2	(	(	-LRB-
cord-252528-rgnhfcbx	54	3	MIP-1α	MIP-1α	NNP
cord-252528-rgnhfcbx	54	4	)	)	-RRB-
cord-252528-rgnhfcbx	54	5	,	,	,
cord-252528-rgnhfcbx	54	6	and	and	CC
cord-252528-rgnhfcbx	54	7	tumor	tumor	NN
cord-252528-rgnhfcbx	54	8	necrosis	necrosis	NN
cord-252528-rgnhfcbx	54	9	factor	factor	NN
cord-252528-rgnhfcbx	54	10	-	-	HYPH
cord-252528-rgnhfcbx	54	11	α	α	NN
cord-252528-rgnhfcbx	54	12	(	(	-LRB-
cord-252528-rgnhfcbx	54	13	TNFα	TNFα	NNP
cord-252528-rgnhfcbx	54	14	)	)	-RRB-
cord-252528-rgnhfcbx	54	15	than	than	IN
cord-252528-rgnhfcbx	54	16	non	non	JJ
cord-252528-rgnhfcbx	54	17	-	-	JJ
cord-252528-rgnhfcbx	54	18	ICU	icu	JJ
cord-252528-rgnhfcbx	54	19	patients	patient	NNS
cord-252528-rgnhfcbx	54	20	(	(	-LRB-
cord-252528-rgnhfcbx	54	21	n	n	NN
cord-252528-rgnhfcbx	54	22	=	=	SYM
cord-252528-rgnhfcbx	54	23	28	28	CD
cord-252528-rgnhfcbx	54	24	)	)	-RRB-
cord-252528-rgnhfcbx	54	25	.	.	.
cord-252528-rgnhfcbx	55	1	Compared	compare	VBN
cord-252528-rgnhfcbx	55	2	to	to	IN
cord-252528-rgnhfcbx	55	3	healthy	healthy	JJ
cord-252528-rgnhfcbx	55	4	adults	adult	NNS
cord-252528-rgnhfcbx	55	5	,	,	,
cord-252528-rgnhfcbx	55	6	both	both	CC
cord-252528-rgnhfcbx	55	7	ICU	ICU	NNP
cord-252528-rgnhfcbx	55	8	and	and	CC
cord-252528-rgnhfcbx	55	9	non	non	JJ
cord-252528-rgnhfcbx	55	10	-	-	JJ
cord-252528-rgnhfcbx	55	11	ICU	icu	JJ
cord-252528-rgnhfcbx	55	12	patients	patient	NNS
cord-252528-rgnhfcbx	55	13	have	have	VBP
cord-252528-rgnhfcbx	55	14	shown	show	VBN
cord-252528-rgnhfcbx	55	15	enhanced	enhance	VBN
cord-252528-rgnhfcbx	55	16	serum	serum	NN
cord-252528-rgnhfcbx	55	17	levels	level	NNS
cord-252528-rgnhfcbx	55	18	of	of	IN
cord-252528-rgnhfcbx	55	19	interleukin-1β	interleukin-1β	NNP
cord-252528-rgnhfcbx	55	20	(	(	-LRB-
cord-252528-rgnhfcbx	55	21	IL-1β	IL-1β	NNP
cord-252528-rgnhfcbx	55	22	)	)	-RRB-
cord-252528-rgnhfcbx	55	23	,	,	,
cord-252528-rgnhfcbx	55	24	interleukin-1	interleukin-1	NNP
cord-252528-rgnhfcbx	55	25	receptor	receptor	NN
cord-252528-rgnhfcbx	55	26	antagonist	antagonist	NN
cord-252528-rgnhfcbx	55	27	(	(	-LRB-
cord-252528-rgnhfcbx	55	28	IL-1RA	IL-1RA	NNP
cord-252528-rgnhfcbx	55	29	)	)	-RRB-
cord-252528-rgnhfcbx	55	30	,	,	,
cord-252528-rgnhfcbx	55	31	IL-7	IL-7	NNP
cord-252528-rgnhfcbx	55	32	,	,	,
cord-252528-rgnhfcbx	55	33	interleukin-8	interleukin-8	NNP
cord-252528-rgnhfcbx	55	34	(	(	-LRB-
cord-252528-rgnhfcbx	55	35	IL-8	IL-8	NNP
cord-252528-rgnhfcbx	55	36	)	)	-RRB-
cord-252528-rgnhfcbx	55	37	,	,	,
cord-252528-rgnhfcbx	55	38	interleukin-9	interleukin-9	NNP
cord-252528-rgnhfcbx	55	39	(	(	-LRB-
cord-252528-rgnhfcbx	55	40	IL-9	IL-9	NNP
cord-252528-rgnhfcbx	55	41	)	)	-RRB-
cord-252528-rgnhfcbx	55	42	,	,	,
cord-252528-rgnhfcbx	55	43	interleukin-10	interleukin-10	FW
cord-252528-rgnhfcbx	55	44	(	(	-LRB-
cord-252528-rgnhfcbx	55	45	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	55	46	)	)	-RRB-
cord-252528-rgnhfcbx	55	47	,	,	,
cord-252528-rgnhfcbx	55	48	basic	basic	JJ
cord-252528-rgnhfcbx	55	49	fibroblast	fibroblast	NN
cord-252528-rgnhfcbx	55	50	growth	growth	NN
cord-252528-rgnhfcbx	55	51	factor	factor	NN
cord-252528-rgnhfcbx	55	52	(	(	-LRB-
cord-252528-rgnhfcbx	55	53	FGF2	FGF2	NNP
cord-252528-rgnhfcbx	55	54	)	)	-RRB-
cord-252528-rgnhfcbx	55	55	,	,	,
cord-252528-rgnhfcbx	55	56	G	G	NNP
cord-252528-rgnhfcbx	55	57	-	-	HYPH
cord-252528-rgnhfcbx	55	58	CSF	CSF	NNP
cord-252528-rgnhfcbx	55	59	,	,	,
cord-252528-rgnhfcbx	55	60	granulocyte	granulocyte	NN
cord-252528-rgnhfcbx	55	61	-	-	HYPH
cord-252528-rgnhfcbx	55	62	macrophage	macrophage	NN
cord-252528-rgnhfcbx	55	63	colony	colony	NN
cord-252528-rgnhfcbx	55	64	-	-	HYPH
cord-252528-rgnhfcbx	55	65	stimulating	stimulate	VBG
cord-252528-rgnhfcbx	55	66	factor	factor	NN
cord-252528-rgnhfcbx	55	67	(	(	-LRB-
cord-252528-rgnhfcbx	55	68	GM	GM	NNP
cord-252528-rgnhfcbx	55	69	-	-	HYPH
cord-252528-rgnhfcbx	55	70	CSF	CSF	NNP
cord-252528-rgnhfcbx	55	71	)	)	-RRB-
cord-252528-rgnhfcbx	55	72	,	,	,
cord-252528-rgnhfcbx	55	73	IFN	IFN	NNP
cord-252528-rgnhfcbx	55	74	-	-	HYPH
cord-252528-rgnhfcbx	55	75	γ	γ	NNP
cord-252528-rgnhfcbx	55	76	,	,	,
cord-252528-rgnhfcbx	55	77	IP-10	IP-10	NNP
cord-252528-rgnhfcbx	55	78	,	,	,
cord-252528-rgnhfcbx	55	79	MCP-1	MCP-1	NNP
cord-252528-rgnhfcbx	55	80	,	,	,
cord-252528-rgnhfcbx	55	81	MIP-1α	MIP-1α	NNP
cord-252528-rgnhfcbx	55	82	,	,	,
cord-252528-rgnhfcbx	55	83	macrophage	macrophage	NN
cord-252528-rgnhfcbx	55	84	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	55	85	protein	protein	NN
cord-252528-rgnhfcbx	55	86	1-β	1-β	CD
cord-252528-rgnhfcbx	55	87	(	(	-LRB-
cord-252528-rgnhfcbx	55	88	MIP-1β	MIP-1β	NNP
cord-252528-rgnhfcbx	55	89	)	)	-RRB-
cord-252528-rgnhfcbx	55	90	,	,	,
cord-252528-rgnhfcbx	55	91	platelet	platelet	NN
cord-252528-rgnhfcbx	55	92	-	-	HYPH
cord-252528-rgnhfcbx	55	93	derived	derive	VBN
cord-252528-rgnhfcbx	55	94	growth	growth	NN
cord-252528-rgnhfcbx	55	95	factor	factor	NN
cord-252528-rgnhfcbx	55	96	(	(	-LRB-
cord-252528-rgnhfcbx	55	97	PDGF	PDGF	NNP
cord-252528-rgnhfcbx	55	98	)	)	-RRB-
cord-252528-rgnhfcbx	55	99	,	,	,
cord-252528-rgnhfcbx	55	100	TNF	TNF	NNP
cord-252528-rgnhfcbx	55	101	-	-	HYPH
cord-252528-rgnhfcbx	55	102	α	α	NNP
cord-252528-rgnhfcbx	55	103	,	,	,
cord-252528-rgnhfcbx	55	104	and	and	CC
cord-252528-rgnhfcbx	55	105	vascular	vascular	JJ
cord-252528-rgnhfcbx	55	106	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	55	107	growth	growth	NN
cord-252528-rgnhfcbx	55	108	factor	factor	NN
cord-252528-rgnhfcbx	55	109	(	(	-LRB-
cord-252528-rgnhfcbx	55	110	VEGF	VEGF	NNP
cord-252528-rgnhfcbx	55	111	)	)	-RRB-
cord-252528-rgnhfcbx	55	112	[	[	-LRB-
cord-252528-rgnhfcbx	55	113	2	2	CD
cord-252528-rgnhfcbx	55	114	]	]	-RRB-
cord-252528-rgnhfcbx	55	115	.	.	.
cord-252528-rgnhfcbx	56	1	Besides	besides	RB
cord-252528-rgnhfcbx	56	2	,	,	,
cord-252528-rgnhfcbx	56	3	Yang	Yang	NNP
cord-252528-rgnhfcbx	56	4	et	et	NNP
cord-252528-rgnhfcbx	56	5	al	al	NNP
cord-252528-rgnhfcbx	56	6	.	.	NNP
cord-252528-rgnhfcbx	56	7	have	have	VBP
cord-252528-rgnhfcbx	56	8	revealed	reveal	VBN
cord-252528-rgnhfcbx	56	9	a	a	DT
cord-252528-rgnhfcbx	56	10	positive	positive	JJ
cord-252528-rgnhfcbx	56	11	correlation	correlation	NN
cord-252528-rgnhfcbx	56	12	between	between	IN
cord-252528-rgnhfcbx	56	13	the	the	DT
cord-252528-rgnhfcbx	56	14	levels	level	NNS
cord-252528-rgnhfcbx	56	15	of	of	IN
cord-252528-rgnhfcbx	56	16	IP-10	IP-10	NNP
cord-252528-rgnhfcbx	56	17	,	,	,
cord-252528-rgnhfcbx	56	18	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	56	19	chemoattractant	chemoattractant	NNP
cord-252528-rgnhfcbx	56	20	protein-3	protein-3	NNP
cord-252528-rgnhfcbx	56	21	(	(	-LRB-
cord-252528-rgnhfcbx	56	22	MCP-3	MCP-3	NNP
cord-252528-rgnhfcbx	56	23	)	)	-RRB-
cord-252528-rgnhfcbx	56	24	,	,	,
cord-252528-rgnhfcbx	56	25	IL-1RA	IL-1RA	NNP
cord-252528-rgnhfcbx	56	26	in	in	IN
cord-252528-rgnhfcbx	56	27	the	the	DT
cord-252528-rgnhfcbx	56	28	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	56	29	blood	blood	NN
cord-252528-rgnhfcbx	56	30	,	,	,
cord-252528-rgnhfcbx	56	31	and	and	CC
cord-252528-rgnhfcbx	56	32	the	the	DT
cord-252528-rgnhfcbx	56	33	severity	severity	NN
cord-252528-rgnhfcbx	56	34	of	of	IN
cord-252528-rgnhfcbx	56	35	the	the	DT
cord-252528-rgnhfcbx	56	36	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	56	37	infection	infection	NN
cord-252528-rgnhfcbx	56	38	based	base	VBN
cord-252528-rgnhfcbx	56	39	on	on	IN
cord-252528-rgnhfcbx	56	40	the	the	DT
cord-252528-rgnhfcbx	56	41	Murray	Murray	NNP
cord-252528-rgnhfcbx	56	42	score	score	NN
cord-252528-rgnhfcbx	56	43	[	[	-LRB-
cord-252528-rgnhfcbx	56	44	4	4	CD
cord-252528-rgnhfcbx	56	45	]	]	-RRB-
cord-252528-rgnhfcbx	56	46	.	.	.
cord-252528-rgnhfcbx	57	1	Serum	serum	NN
cord-252528-rgnhfcbx	57	2	cytokine	cytokine	NN
cord-252528-rgnhfcbx	57	3	profiles	profile	NNS
cord-252528-rgnhfcbx	57	4	,	,	,
cord-252528-rgnhfcbx	57	5	including	include	VBG
cord-252528-rgnhfcbx	57	6	those	those	DT
cord-252528-rgnhfcbx	57	7	of	of	IN
cord-252528-rgnhfcbx	57	8	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	57	9	,	,	,
cord-252528-rgnhfcbx	57	10	IL-4	IL-4	NNP
cord-252528-rgnhfcbx	57	11	,	,	,
cord-252528-rgnhfcbx	57	12	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	57	13	,	,	,
cord-252528-rgnhfcbx	57	14	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	57	15	,	,	,
cord-252528-rgnhfcbx	57	16	IFN	IFN	NNP
cord-252528-rgnhfcbx	57	17	-	-	HYPH
cord-252528-rgnhfcbx	57	18	γ	γ	NNP
cord-252528-rgnhfcbx	57	19	,	,	,
cord-252528-rgnhfcbx	57	20	and	and	CC
cord-252528-rgnhfcbx	57	21	TNF	TNF	NNP
cord-252528-rgnhfcbx	57	22	-	-	HYPH
cord-252528-rgnhfcbx	57	23	α	α	NNP
cord-252528-rgnhfcbx	57	24	,	,	,
cord-252528-rgnhfcbx	57	25	change	change	VBP
cord-252528-rgnhfcbx	57	26	dynamically	dynamically	RB
cord-252528-rgnhfcbx	57	27	after	after	IN
cord-252528-rgnhfcbx	57	28	the	the	DT
cord-252528-rgnhfcbx	57	29	disease	disease	NN
cord-252528-rgnhfcbx	57	30	onset	onset	NN
cord-252528-rgnhfcbx	57	31	in	in	IN
cord-252528-rgnhfcbx	57	32	severe	severe	JJ
cord-252528-rgnhfcbx	57	33	patients	patient	NNS
cord-252528-rgnhfcbx	57	34	,	,	,
cord-252528-rgnhfcbx	57	35	reaching	reach	VBG
cord-252528-rgnhfcbx	57	36	their	-PRON-	PRP$
cord-252528-rgnhfcbx	57	37	peak	peak	NN
cord-252528-rgnhfcbx	57	38	levels	level	NNS
cord-252528-rgnhfcbx	57	39	in	in	IN
cord-252528-rgnhfcbx	57	40	4	4	CD
cord-252528-rgnhfcbx	57	41	to	to	TO
cord-252528-rgnhfcbx	57	42	6	6	CD
cord-252528-rgnhfcbx	57	43	days	day	NNS
cord-252528-rgnhfcbx	57	44	after	after	IN
cord-252528-rgnhfcbx	57	45	the	the	DT
cord-252528-rgnhfcbx	57	46	disease	disease	NN
cord-252528-rgnhfcbx	57	47	onset	onset	NN
cord-252528-rgnhfcbx	57	48	[	[	-LRB-
cord-252528-rgnhfcbx	57	49	5	5	CD
cord-252528-rgnhfcbx	57	50	]	]	-RRB-
cord-252528-rgnhfcbx	57	51	.	.	.
cord-252528-rgnhfcbx	58	1	After	after	IN
cord-252528-rgnhfcbx	58	2	the	the	DT
cord-252528-rgnhfcbx	58	3	disease	disease	NN
cord-252528-rgnhfcbx	58	4	onset	onset	NN
cord-252528-rgnhfcbx	58	5	,	,	,
cord-252528-rgnhfcbx	58	6	while	while	IN
cord-252528-rgnhfcbx	58	7	mild	mild	JJ
cord-252528-rgnhfcbx	58	8	patients	patient	NNS
cord-252528-rgnhfcbx	58	9	have	have	VBP
cord-252528-rgnhfcbx	58	10	not	not	RB
cord-252528-rgnhfcbx	58	11	had	have	VBN
cord-252528-rgnhfcbx	58	12	remarkable	remarkable	JJ
cord-252528-rgnhfcbx	58	13	fluctuations	fluctuation	NNS
cord-252528-rgnhfcbx	58	14	in	in	IN
cord-252528-rgnhfcbx	58	15	the	the	DT
cord-252528-rgnhfcbx	58	16	serum	serum	NN
cord-252528-rgnhfcbx	58	17	levels	level	NNS
cord-252528-rgnhfcbx	58	18	of	of	IN
cord-252528-rgnhfcbx	58	19	any	any	DT
cord-252528-rgnhfcbx	58	20	of	of	IN
cord-252528-rgnhfcbx	58	21	these	these	DT
cord-252528-rgnhfcbx	58	22	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	58	23	,	,	,
cord-252528-rgnhfcbx	58	24	significant	significant	JJ
cord-252528-rgnhfcbx	58	25	fluctuations	fluctuation	NNS
cord-252528-rgnhfcbx	58	26	in	in	IN
cord-252528-rgnhfcbx	58	27	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	58	28	and	and	CC
cord-252528-rgnhfcbx	58	29	IFN	IFN	NNP
cord-252528-rgnhfcbx	58	30	-	-	HYPH
cord-252528-rgnhfcbx	58	31	γ	γ	NN
cord-252528-rgnhfcbx	58	32	serum	serum	NN
cord-252528-rgnhfcbx	58	33	levels	level	NNS
cord-252528-rgnhfcbx	58	34	have	have	VBP
cord-252528-rgnhfcbx	58	35	been	be	VBN
cord-252528-rgnhfcbx	58	36	discovered	discover	VBN
cord-252528-rgnhfcbx	58	37	in	in	IN
cord-252528-rgnhfcbx	58	38	severe	severe	JJ
cord-252528-rgnhfcbx	58	39	patients	patient	NNS
cord-252528-rgnhfcbx	58	40	.	.	.
cord-252528-rgnhfcbx	59	1	In	in	IN
cord-252528-rgnhfcbx	59	2	severe	severe	JJ
cord-252528-rgnhfcbx	59	3	patients	patient	NNS
cord-252528-rgnhfcbx	59	4	,	,	,
cord-252528-rgnhfcbx	59	5	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	59	6	and	and	CC
cord-252528-rgnhfcbx	59	7	IFN	IFN	NNP
cord-252528-rgnhfcbx	59	8	-	-	HYPH
cord-252528-rgnhfcbx	59	9	γ	γ	NN
cord-252528-rgnhfcbx	59	10	serum	serum	NN
cord-252528-rgnhfcbx	59	11	levels	level	NNS
cord-252528-rgnhfcbx	59	12	have	have	VBP
cord-252528-rgnhfcbx	59	13	declined	decline	VBN
cord-252528-rgnhfcbx	59	14	to	to	IN
cord-252528-rgnhfcbx	59	15	the	the	DT
cord-252528-rgnhfcbx	59	16	initial	initial	JJ
cord-252528-rgnhfcbx	59	17	level	level	NN
cord-252528-rgnhfcbx	59	18	in	in	IN
cord-252528-rgnhfcbx	59	19	7	7	CD
cord-252528-rgnhfcbx	59	20	-	-	SYM
cord-252528-rgnhfcbx	59	21	9	9	CD
cord-252528-rgnhfcbx	59	22	days	day	NNS
cord-252528-rgnhfcbx	59	23	after	after	IN
cord-252528-rgnhfcbx	59	24	the	the	DT
cord-252528-rgnhfcbx	59	25	disease	disease	NN
cord-252528-rgnhfcbx	59	26	onset	onset	NN
cord-252528-rgnhfcbx	59	27	.	.	.
cord-252528-rgnhfcbx	60	1	The	the	DT
cord-252528-rgnhfcbx	60	2	serum	serum	NN
cord-252528-rgnhfcbx	60	3	level	level	NN
cord-252528-rgnhfcbx	60	4	of	of	IN
cord-252528-rgnhfcbx	60	5	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	60	6	has	have	VBZ
cord-252528-rgnhfcbx	60	7	remained	remain	VBN
cord-252528-rgnhfcbx	60	8	continuously	continuously	RB
cord-252528-rgnhfcbx	60	9	higher	high	JJR
cord-252528-rgnhfcbx	60	10	in	in	IN
cord-252528-rgnhfcbx	60	11	severe	severe	JJ
cord-252528-rgnhfcbx	60	12	patients	patient	NNS
cord-252528-rgnhfcbx	60	13	than	than	IN
cord-252528-rgnhfcbx	60	14	in	in	IN
cord-252528-rgnhfcbx	60	15	mild	mild	JJ
cord-252528-rgnhfcbx	60	16	patients	patient	NNS
cord-252528-rgnhfcbx	60	17	,	,	,
cord-252528-rgnhfcbx	60	18	and	and	CC
cord-252528-rgnhfcbx	60	19	the	the	DT
cord-252528-rgnhfcbx	60	20	serum	serum	NN
cord-252528-rgnhfcbx	60	21	level	level	NN
cord-252528-rgnhfcbx	60	22	of	of	IN
cord-252528-rgnhfcbx	60	23	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	60	24	has	have	VBZ
cord-252528-rgnhfcbx	60	25	remained	remain	VBN
cord-252528-rgnhfcbx	60	26	higher	high	JJR
cord-252528-rgnhfcbx	60	27	in	in	IN
cord-252528-rgnhfcbx	60	28	severe	severe	JJ
cord-252528-rgnhfcbx	60	29	patients	patient	NNS
cord-252528-rgnhfcbx	60	30	than	than	IN
cord-252528-rgnhfcbx	60	31	in	in	IN
cord-252528-rgnhfcbx	60	32	mild	mild	JJ
cord-252528-rgnhfcbx	60	33	patients	patient	NNS
cord-252528-rgnhfcbx	60	34	by	by	IN
cord-252528-rgnhfcbx	60	35	the	the	DT
cord-252528-rgnhfcbx	60	36	end	end	NN
cord-252528-rgnhfcbx	60	37	of	of	IN
cord-252528-rgnhfcbx	60	38	13	13	CD
cord-252528-rgnhfcbx	60	39	-	-	SYM
cord-252528-rgnhfcbx	60	40	15	15	CD
cord-252528-rgnhfcbx	60	41	days	day	NNS
cord-252528-rgnhfcbx	60	42	after	after	IN
cord-252528-rgnhfcbx	60	43	the	the	DT
cord-252528-rgnhfcbx	60	44	disease	disease	NN
cord-252528-rgnhfcbx	60	45	onset	onset	NN
cord-252528-rgnhfcbx	60	46	.	.	.
cord-252528-rgnhfcbx	61	1	However	however	RB
cord-252528-rgnhfcbx	61	2	,	,	,
cord-252528-rgnhfcbx	61	3	no	no	DT
cord-252528-rgnhfcbx	61	4	significant	significant	JJ
cord-252528-rgnhfcbx	61	5	difference	difference	NN
cord-252528-rgnhfcbx	61	6	in	in	IN
cord-252528-rgnhfcbx	61	7	serum	serum	NN
cord-252528-rgnhfcbx	61	8	levels	level	NNS
cord-252528-rgnhfcbx	61	9	of	of	IN
cord-252528-rgnhfcbx	61	10	IL-4	IL-4	NNP
cord-252528-rgnhfcbx	61	11	and	and	CC
cord-252528-rgnhfcbx	61	12	TNF	TNF	NNP
cord-252528-rgnhfcbx	61	13	-	-	HYPH
cord-252528-rgnhfcbx	61	14	α	α	NN
cord-252528-rgnhfcbx	61	15	between	between	IN
cord-252528-rgnhfcbx	61	16	mild	mild	JJ
cord-252528-rgnhfcbx	61	17	and	and	CC
cord-252528-rgnhfcbx	61	18	severe	severe	JJ
cord-252528-rgnhfcbx	61	19	patients	patient	NNS
cord-252528-rgnhfcbx	61	20	has	have	VBZ
cord-252528-rgnhfcbx	61	21	been	be	VBN
cord-252528-rgnhfcbx	61	22	detected	detect	VBN
cord-252528-rgnhfcbx	61	23	throughout	throughout	IN
cord-252528-rgnhfcbx	61	24	the	the	DT
cord-252528-rgnhfcbx	61	25	whole	whole	JJ
cord-252528-rgnhfcbx	61	26	course	course	NN
cord-252528-rgnhfcbx	61	27	of	of	IN
cord-252528-rgnhfcbx	61	28	the	the	DT
cord-252528-rgnhfcbx	61	29	disease	disease	NN
cord-252528-rgnhfcbx	61	30	[	[	-LRB-
cord-252528-rgnhfcbx	61	31	5	5	CD
cord-252528-rgnhfcbx	61	32	]	]	-RRB-
cord-252528-rgnhfcbx	61	33	.	.	.
cord-252528-rgnhfcbx	62	1	A	a	DT
cord-252528-rgnhfcbx	62	2	report	report	NN
cord-252528-rgnhfcbx	62	3	by	by	IN
cord-252528-rgnhfcbx	62	4	Zhou	Zhou	NNP
cord-252528-rgnhfcbx	62	5	et	et	NNP
cord-252528-rgnhfcbx	62	6	al	al	NNP
cord-252528-rgnhfcbx	62	7	.	.	NNP
cord-252528-rgnhfcbx	62	8	reveals	reveal	VBZ
cord-252528-rgnhfcbx	62	9	the	the	DT
cord-252528-rgnhfcbx	62	10	immuno	immuno	JJ
cord-252528-rgnhfcbx	62	11	-	-	JJ
cord-252528-rgnhfcbx	62	12	pathological	pathological	JJ
cord-252528-rgnhfcbx	62	13	basis	basis	NN
cord-252528-rgnhfcbx	62	14	behind	behind	IN
cord-252528-rgnhfcbx	62	15	the	the	DT
cord-252528-rgnhfcbx	62	16	hyper	hyper	JJ
cord-252528-rgnhfcbx	62	17	-	-	JJ
cord-252528-rgnhfcbx	62	18	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	62	19	immune	immune	JJ
cord-252528-rgnhfcbx	62	20	response	response	NN
cord-252528-rgnhfcbx	62	21	associated	associate	VBN
cord-252528-rgnhfcbx	62	22	with	with	IN
cord-252528-rgnhfcbx	62	23	severe	severe	JJ
cord-252528-rgnhfcbx	62	24	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	62	25	.	.	.
cord-252528-rgnhfcbx	63	1	By	by	IN
cord-252528-rgnhfcbx	63	2	intracellular	intracellular	JJ
cord-252528-rgnhfcbx	63	3	staining	staining	NN
cord-252528-rgnhfcbx	63	4	of	of	IN
cord-252528-rgnhfcbx	63	5	potential	potential	JJ
cord-252528-rgnhfcbx	63	6	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	63	7	responsible	responsible	JJ
cord-252528-rgnhfcbx	63	8	for	for	IN
cord-252528-rgnhfcbx	63	9	promoting	promote	VBG
cord-252528-rgnhfcbx	63	10	cytokine	cytokine	JJ
cord-252528-rgnhfcbx	63	11	storm	storm	NN
cord-252528-rgnhfcbx	63	12	in	in	IN
cord-252528-rgnhfcbx	63	13	SARS	SARS	NNP
cord-252528-rgnhfcbx	63	14	and	and	CC
cord-252528-rgnhfcbx	63	15	MERS	MERS	NNP
cord-252528-rgnhfcbx	63	16	,	,	,
cord-252528-rgnhfcbx	63	17	Zhou	Zhou	NNP
cord-252528-rgnhfcbx	63	18	et	et	NNP
cord-252528-rgnhfcbx	63	19	al	al	NNP
cord-252528-rgnhfcbx	63	20	.	.	NNP
cord-252528-rgnhfcbx	63	21	have	have	VBP
cord-252528-rgnhfcbx	63	22	demonstrated	demonstrate	VBN
cord-252528-rgnhfcbx	63	23	that	that	IN
cord-252528-rgnhfcbx	63	24	compared	compare	VBN
cord-252528-rgnhfcbx	63	25	to	to	IN
cord-252528-rgnhfcbx	63	26	healthy	healthy	JJ
cord-252528-rgnhfcbx	63	27	individuals	individual	NNS
cord-252528-rgnhfcbx	63	28	,	,	,
cord-252528-rgnhfcbx	63	29	ICU	ICU	NNP
cord-252528-rgnhfcbx	63	30	and	and	CC
cord-252528-rgnhfcbx	63	31	non	non	JJ
cord-252528-rgnhfcbx	63	32	-	-	JJ
cord-252528-rgnhfcbx	63	33	ICU	icu	JJ
cord-252528-rgnhfcbx	63	34	patients	patient	NNS
cord-252528-rgnhfcbx	63	35	have	have	VBP
cord-252528-rgnhfcbx	63	36	increased	increase	VBN
cord-252528-rgnhfcbx	63	37	expressions	expression	NNS
cord-252528-rgnhfcbx	63	38	of	of	IN
cord-252528-rgnhfcbx	63	39	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	63	40	and	and	CC
cord-252528-rgnhfcbx	63	41	GM	GM	NNP
cord-252528-rgnhfcbx	63	42	-	-	HYPH
cord-252528-rgnhfcbx	63	43	CSF	CSF	NNP
cord-252528-rgnhfcbx	63	44	in	in	IN
cord-252528-rgnhfcbx	63	45	the	the	DT
cord-252528-rgnhfcbx	63	46	CD4	CD4	NNP
cord-252528-rgnhfcbx	63	47	+	+	CC
cord-252528-rgnhfcbx	63	48	T	t	NN
cord-252528-rgnhfcbx	63	49	cells	cell	NNS
cord-252528-rgnhfcbx	63	50	.	.	.
cord-252528-rgnhfcbx	64	1	Moreover	moreover	RB
cord-252528-rgnhfcbx	64	2	,	,	,
cord-252528-rgnhfcbx	64	3	the	the	DT
cord-252528-rgnhfcbx	64	4	extent	extent	NN
cord-252528-rgnhfcbx	64	5	of	of	IN
cord-252528-rgnhfcbx	64	6	the	the	DT
cord-252528-rgnhfcbx	64	7	increment	increment	NN
cord-252528-rgnhfcbx	64	8	in	in	IN
cord-252528-rgnhfcbx	64	9	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	64	10	and	and	CC
cord-252528-rgnhfcbx	64	11	GM	GM	NNP
cord-252528-rgnhfcbx	64	12	-	-	HYPH
cord-252528-rgnhfcbx	64	13	CSF	CSF	NNP
cord-252528-rgnhfcbx	64	14	expressions	expression	NNS
cord-252528-rgnhfcbx	64	15	in	in	IN
cord-252528-rgnhfcbx	64	16	CD4	CD4	NNP
cord-252528-rgnhfcbx	64	17	+	+	CC
cord-252528-rgnhfcbx	64	18	T	t	NN
cord-252528-rgnhfcbx	64	19	cells	cell	NNS
cord-252528-rgnhfcbx	64	20	is	be	VBZ
cord-252528-rgnhfcbx	64	21	correlated	correlate	VBN
cord-252528-rgnhfcbx	64	22	with	with	IN
cord-252528-rgnhfcbx	64	23	the	the	DT
cord-252528-rgnhfcbx	64	24	severity	severity	NN
cord-252528-rgnhfcbx	64	25	of	of	IN
cord-252528-rgnhfcbx	64	26	disease	disease	NN
cord-252528-rgnhfcbx	64	27	manifestations	manifestation	NNS
cord-252528-rgnhfcbx	64	28	(	(	-LRB-
cord-252528-rgnhfcbx	64	29	Fig	Fig	NNP
cord-252528-rgnhfcbx	64	30	.	.	.
cord-252528-rgnhfcbx	64	31	1	1	CD
cord-252528-rgnhfcbx	64	32	)	)	-RRB-
cord-252528-rgnhfcbx	64	33	.	.	.
cord-252528-rgnhfcbx	65	1	Th1	th1	NN
cord-252528-rgnhfcbx	65	2	cells	cell	NNS
cord-252528-rgnhfcbx	65	3	,	,	,
cord-252528-rgnhfcbx	65	4	positively	positively	RB
cord-252528-rgnhfcbx	65	5	stained	stain	VBN
cord-252528-rgnhfcbx	65	6	for	for	IN
cord-252528-rgnhfcbx	65	7	both	both	DT
cord-252528-rgnhfcbx	65	8	GM	GM	NNP
cord-252528-rgnhfcbx	65	9	-	-	HYPH
cord-252528-rgnhfcbx	65	10	CSF	CSF	NNP
cord-252528-rgnhfcbx	65	11	and	and	CC
cord-252528-rgnhfcbx	65	12	IFNγ	IFNγ	NNS
cord-252528-rgnhfcbx	65	13	,	,	,
cord-252528-rgnhfcbx	65	14	are	be	VBP
cord-252528-rgnhfcbx	65	15	only	only	RB
cord-252528-rgnhfcbx	65	16	present	present	JJ
cord-252528-rgnhfcbx	65	17	in	in	IN
cord-252528-rgnhfcbx	65	18	ICU	ICU	NNP
cord-252528-rgnhfcbx	65	19	patients	patient	NNS
cord-252528-rgnhfcbx	65	20	,	,	,
cord-252528-rgnhfcbx	65	21	but	but	CC
cord-252528-rgnhfcbx	65	22	not	not	RB
cord-252528-rgnhfcbx	65	23	in	in	IN
cord-252528-rgnhfcbx	65	24	non	non	JJ
cord-252528-rgnhfcbx	65	25	-	-	JJ
cord-252528-rgnhfcbx	65	26	ICU	icu	JJ
cord-252528-rgnhfcbx	65	27	patients	patient	NNS
cord-252528-rgnhfcbx	65	28	.	.	.
cord-252528-rgnhfcbx	66	1	This	this	DT
cord-252528-rgnhfcbx	66	2	phenomenon	phenomenon	NN
cord-252528-rgnhfcbx	66	3	,	,	,
cord-252528-rgnhfcbx	66	4	in	in	IN
cord-252528-rgnhfcbx	66	5	part	part	NN
cord-252528-rgnhfcbx	66	6	,	,	,
cord-252528-rgnhfcbx	66	7	explains	explain	VBZ
cord-252528-rgnhfcbx	66	8	the	the	DT
cord-252528-rgnhfcbx	66	9	over	over	RB
cord-252528-rgnhfcbx	66	10	-	-	HYPH
cord-252528-rgnhfcbx	66	11	activated	activate	VBN
cord-252528-rgnhfcbx	66	12	inflammation	inflammation	NN
cord-252528-rgnhfcbx	66	13	in	in	IN
cord-252528-rgnhfcbx	66	14	severe	severe	JJ
cord-252528-rgnhfcbx	66	15	patients	patient	NNS
cord-252528-rgnhfcbx	66	16	with	with	IN
cord-252528-rgnhfcbx	66	17	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	66	18	[	[	-LRB-
cord-252528-rgnhfcbx	66	19	6	6	CD
cord-252528-rgnhfcbx	66	20	]	]	-RRB-
cord-252528-rgnhfcbx	66	21	.	.	.
cord-252528-rgnhfcbx	67	1	Enhanced	enhanced	JJ
cord-252528-rgnhfcbx	67	2	plasma	plasma	NN
cord-252528-rgnhfcbx	67	3	levels	level	NNS
cord-252528-rgnhfcbx	67	4	of	of	IN
cord-252528-rgnhfcbx	67	5	activated	activate	VBN
cord-252528-rgnhfcbx	67	6	CD14	CD14	NNP
cord-252528-rgnhfcbx	67	7	+	+	CC
cord-252528-rgnhfcbx	67	8	CD16	CD16	NNP
cord-252528-rgnhfcbx	67	9	+	+	CC
cord-252528-rgnhfcbx	67	10	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	67	11	capable	capable	JJ
cord-252528-rgnhfcbx	67	12	of	of	IN
cord-252528-rgnhfcbx	67	13	producing	produce	VBG
cord-252528-rgnhfcbx	67	14	pro	pro	JJ
cord-252528-rgnhfcbx	67	15	-	-	JJ
cord-252528-rgnhfcbx	67	16	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	67	17	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	67	18	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	67	19	and	and	CC
cord-252528-rgnhfcbx	68	1	GM	GM	NNP
cord-252528-rgnhfcbx	68	2	-	-	HYPH
cord-252528-rgnhfcbx	68	3	CSF	CSF	NNP
cord-252528-rgnhfcbx	68	4	are	be	VBP
cord-252528-rgnhfcbx	68	5	found	find	VBN
cord-252528-rgnhfcbx	68	6	only	only	RB
cord-252528-rgnhfcbx	68	7	in	in	IN
cord-252528-rgnhfcbx	68	8	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	68	9	patients	patient	NNS
cord-252528-rgnhfcbx	68	10	,	,	,
cord-252528-rgnhfcbx	68	11	but	but	CC
cord-252528-rgnhfcbx	68	12	not	not	RB
cord-252528-rgnhfcbx	68	13	in	in	IN
cord-252528-rgnhfcbx	68	14	healthy	healthy	JJ
cord-252528-rgnhfcbx	68	15	individuals	individual	NNS
cord-252528-rgnhfcbx	68	16	[	[	-LRB-
cord-252528-rgnhfcbx	68	17	6	6	CD
cord-252528-rgnhfcbx	68	18	]	]	-RRB-
cord-252528-rgnhfcbx	68	19	.	.	.
cord-252528-rgnhfcbx	69	1	Acting	act	VBG
cord-252528-rgnhfcbx	69	2	on	on	IN
cord-252528-rgnhfcbx	69	3	the	the	DT
cord-252528-rgnhfcbx	69	4	GM	GM	NNP
cord-252528-rgnhfcbx	69	5	-	-	HYPH
cord-252528-rgnhfcbx	69	6	CSF	CSF	NNP
cord-252528-rgnhfcbx	69	7	receptors	receptor	NNS
cord-252528-rgnhfcbx	69	8	on	on	IN
cord-252528-rgnhfcbx	69	9	myeloid	myeloid	JJ
cord-252528-rgnhfcbx	69	10	cells	cell	NNS
cord-252528-rgnhfcbx	69	11	,	,	,
cord-252528-rgnhfcbx	69	12	GM	GM	NNP
cord-252528-rgnhfcbx	69	13	-	-	HYPH
cord-252528-rgnhfcbx	69	14	CSF	CSF	NNP
cord-252528-rgnhfcbx	69	15	leads	lead	VBZ
cord-252528-rgnhfcbx	69	16	to	to	IN
cord-252528-rgnhfcbx	69	17	activation	activation	NN
cord-252528-rgnhfcbx	69	18	of	of	IN
cord-252528-rgnhfcbx	69	19	the	the	DT
cord-252528-rgnhfcbx	69	20	Janus	Janus	NNP
cord-252528-rgnhfcbx	69	21	kinase2-signal	kinase2-signal	JJ
cord-252528-rgnhfcbx	69	22	transducer	transducer	NN
cord-252528-rgnhfcbx	69	23	and	and	CC
cord-252528-rgnhfcbx	69	24	activator	activator	NN
cord-252528-rgnhfcbx	69	25	of	of	IN
cord-252528-rgnhfcbx	69	26	transcription5	transcription5	NNP
cord-252528-rgnhfcbx	69	27	(	(	-LRB-
cord-252528-rgnhfcbx	69	28	JAK2-STAT5	JAK2-STAT5	NNP
cord-252528-rgnhfcbx	69	29	)	)	-RRB-
cord-252528-rgnhfcbx	69	30	pathway	pathway	NN
cord-252528-rgnhfcbx	69	31	,	,	,
cord-252528-rgnhfcbx	69	32	influencing	influence	VBG
cord-252528-rgnhfcbx	69	33	both	both	CC
cord-252528-rgnhfcbx	69	34	the	the	DT
cord-252528-rgnhfcbx	69	35	differentiation	differentiation	NN
cord-252528-rgnhfcbx	69	36	of	of	IN
cord-252528-rgnhfcbx	69	37	myeloid	myeloid	JJ
cord-252528-rgnhfcbx	69	38	precursor	precursor	NN
cord-252528-rgnhfcbx	69	39	cells	cell	NNS
cord-252528-rgnhfcbx	69	40	and	and	CC
cord-252528-rgnhfcbx	69	41	the	the	DT
cord-252528-rgnhfcbx	69	42	polarization	polarization	NN
cord-252528-rgnhfcbx	69	43	of	of	IN
cord-252528-rgnhfcbx	69	44	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	69	45	[	[	-LRB-
cord-252528-rgnhfcbx	69	46	18	18	CD
cord-252528-rgnhfcbx	69	47	]	]	-RRB-
cord-252528-rgnhfcbx	69	48	.	.	.
cord-252528-rgnhfcbx	70	1	Although	although	IN
cord-252528-rgnhfcbx	70	2	the	the	DT
cord-252528-rgnhfcbx	70	3	activity	activity	NN
cord-252528-rgnhfcbx	70	4	of	of	IN
cord-252528-rgnhfcbx	70	5	GM	GM	NNP
cord-252528-rgnhfcbx	70	6	-	-	HYPH
cord-252528-rgnhfcbx	70	7	CSF	CSF	NNP
cord-252528-rgnhfcbx	70	8	is	be	VBZ
cord-252528-rgnhfcbx	70	9	redundant	redundant	JJ
cord-252528-rgnhfcbx	70	10	in	in	IN
cord-252528-rgnhfcbx	70	11	physiological	physiological	JJ
cord-252528-rgnhfcbx	70	12	myeloid	myeloid	NN
cord-252528-rgnhfcbx	70	13	hematopoiesis	hematopoiesis	NN
cord-252528-rgnhfcbx	70	14	because	because	IN
cord-252528-rgnhfcbx	70	15	of	of	IN
cord-252528-rgnhfcbx	70	16	the	the	DT
cord-252528-rgnhfcbx	70	17	presence	presence	NN
cord-252528-rgnhfcbx	70	18	of	of	IN
cord-252528-rgnhfcbx	70	19	G	G	NNP
cord-252528-rgnhfcbx	70	20	-	-	HYPH
cord-252528-rgnhfcbx	70	21	CSF	csf	NN
cord-252528-rgnhfcbx	70	22	and	and	CC
cord-252528-rgnhfcbx	70	23	macrophage	macrophage	NN
cord-252528-rgnhfcbx	70	24	-	-	HYPH
cord-252528-rgnhfcbx	70	25	colony	colony	NN
cord-252528-rgnhfcbx	70	26	stimulating	stimulating	NN
cord-252528-rgnhfcbx	70	27	factor	factor	NN
cord-252528-rgnhfcbx	70	28	(	(	-LRB-
cord-252528-rgnhfcbx	70	29	M	M	NNP
cord-252528-rgnhfcbx	70	30	-	-	HYPH
cord-252528-rgnhfcbx	70	31	CSF	CSF	NNP
cord-252528-rgnhfcbx	70	32	)	)	-RRB-
cord-252528-rgnhfcbx	70	33	,	,	,
cord-252528-rgnhfcbx	70	34	GM	GM	NNP
cord-252528-rgnhfcbx	70	35	-	-	HYPH
cord-252528-rgnhfcbx	70	36	CSF	CSF	NNP
cord-252528-rgnhfcbx	70	37	is	be	VBZ
cord-252528-rgnhfcbx	70	38	responsible	responsible	JJ
cord-252528-rgnhfcbx	70	39	for	for	IN
cord-252528-rgnhfcbx	70	40	emergent	emergent	JJ
cord-252528-rgnhfcbx	70	41	hematopoiesis	hematopoiesis	NN
cord-252528-rgnhfcbx	70	42	in	in	IN
cord-252528-rgnhfcbx	70	43	acute	acute	JJ
cord-252528-rgnhfcbx	70	44	pathological	pathological	JJ
cord-252528-rgnhfcbx	70	45	conditions	condition	NNS
cord-252528-rgnhfcbx	70	46	such	such	JJ
cord-252528-rgnhfcbx	70	47	as	as	IN
cord-252528-rgnhfcbx	70	48	acute	acute	JJ
cord-252528-rgnhfcbx	70	49	infections	infection	NNS
cord-252528-rgnhfcbx	70	50	,	,	,
cord-252528-rgnhfcbx	70	51	in	in	IN
cord-252528-rgnhfcbx	70	52	accordance	accordance	NN
cord-252528-rgnhfcbx	70	53	with	with	IN
cord-252528-rgnhfcbx	70	54	the	the	DT
cord-252528-rgnhfcbx	70	55	sudden	sudden	JJ
cord-252528-rgnhfcbx	70	56	increment	increment	NN
cord-252528-rgnhfcbx	70	57	of	of	IN
cord-252528-rgnhfcbx	70	58	its	-PRON-	PRP$
cord-252528-rgnhfcbx	70	59	serum	serum	NN
cord-252528-rgnhfcbx	70	60	level	level	NN
cord-252528-rgnhfcbx	70	61	following	follow	VBG
cord-252528-rgnhfcbx	70	62	an	an	DT
cord-252528-rgnhfcbx	70	63	acute	acute	JJ
cord-252528-rgnhfcbx	70	64	infection	infection	NN
cord-252528-rgnhfcbx	70	65	[	[	-LRB-
cord-252528-rgnhfcbx	70	66	19	19	CD
cord-252528-rgnhfcbx	70	67	]	]	-RRB-
cord-252528-rgnhfcbx	70	68	.	.	.
cord-252528-rgnhfcbx	71	1	In	in	IN
cord-252528-rgnhfcbx	71	2	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	71	3	,	,	,
cord-252528-rgnhfcbx	71	4	enhanced	enhance	VBN
cord-252528-rgnhfcbx	71	5	GM	GM	NNP
cord-252528-rgnhfcbx	71	6	-	-	HYPH
cord-252528-rgnhfcbx	71	7	CSF	csf	NN
cord-252528-rgnhfcbx	71	8	level	level	NN
cord-252528-rgnhfcbx	71	9	can	can	MD
cord-252528-rgnhfcbx	71	10	increase	increase	VB
cord-252528-rgnhfcbx	71	11	the	the	DT
cord-252528-rgnhfcbx	71	12	GM	GM	NNP
cord-252528-rgnhfcbx	71	13	-	-	HYPH
cord-252528-rgnhfcbx	71	14	CSF	csf	NN
cord-252528-rgnhfcbx	71	15	receptor	receptor	NN
cord-252528-rgnhfcbx	71	16	signal	signal	NN
cord-252528-rgnhfcbx	71	17	strength	strength	NN
cord-252528-rgnhfcbx	71	18	in	in	IN
cord-252528-rgnhfcbx	71	19	myeloid	myeloid	NN
cord-252528-rgnhfcbx	71	20	cells	cell	NNS
cord-252528-rgnhfcbx	71	21	,	,	,
cord-252528-rgnhfcbx	71	22	promoting	promote	VBG
cord-252528-rgnhfcbx	71	23	their	-PRON-	PRP$
cord-252528-rgnhfcbx	71	24	differentiation	differentiation	NN
cord-252528-rgnhfcbx	71	25	into	into	IN
cord-252528-rgnhfcbx	71	26	proinflammatory	proinflammatory	JJ
cord-252528-rgnhfcbx	71	27	macrophage	macrophage	NN
cord-252528-rgnhfcbx	71	28	subtype	subtype	NN
cord-252528-rgnhfcbx	71	29	[	[	-LRB-
cord-252528-rgnhfcbx	71	30	19	19	CD
cord-252528-rgnhfcbx	71	31	]	]	-RRB-
cord-252528-rgnhfcbx	71	32	.	.	.
cord-252528-rgnhfcbx	72	1	An	an	DT
cord-252528-rgnhfcbx	72	2	in	in	IN
cord-252528-rgnhfcbx	72	3	vivo	vivo	NN
cord-252528-rgnhfcbx	72	4	study	study	NN
cord-252528-rgnhfcbx	72	5	suggests	suggest	VBZ
cord-252528-rgnhfcbx	72	6	that	that	IN
cord-252528-rgnhfcbx	72	7	GM	GM	NNP
cord-252528-rgnhfcbx	72	8	-	-	HYPH
cord-252528-rgnhfcbx	72	9	CSF	CSF	NNP
cord-252528-rgnhfcbx	72	10	dependent	dependent	JJ
cord-252528-rgnhfcbx	72	11	PU.1	PU.1	NNP
cord-252528-rgnhfcbx	72	12	expression	expression	NN
cord-252528-rgnhfcbx	72	13	mediates	mediate	VBZ
cord-252528-rgnhfcbx	72	14	the	the	DT
cord-252528-rgnhfcbx	72	15	terminal	terminal	JJ
cord-252528-rgnhfcbx	72	16	differentiation	differentiation	NN
cord-252528-rgnhfcbx	72	17	of	of	IN
cord-252528-rgnhfcbx	72	18	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	72	19	and	and	CC
cord-252528-rgnhfcbx	72	20	the	the	DT
cord-252528-rgnhfcbx	72	21	enhancement	enhancement	NN
cord-252528-rgnhfcbx	72	22	in	in	IN
cord-252528-rgnhfcbx	72	23	phagocytic	phagocytic	JJ
cord-252528-rgnhfcbx	72	24	activities	activity	NNS
cord-252528-rgnhfcbx	72	25	of	of	IN
cord-252528-rgnhfcbx	72	26	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	72	27	[	[	-LRB-
cord-252528-rgnhfcbx	72	28	20	20	CD
cord-252528-rgnhfcbx	72	29	]	]	-RRB-
cord-252528-rgnhfcbx	72	30	.	.	.
cord-252528-rgnhfcbx	73	1	Besides	besides	IN
cord-252528-rgnhfcbx	73	2	the	the	DT
cord-252528-rgnhfcbx	73	3	role	role	NN
cord-252528-rgnhfcbx	73	4	of	of	IN
cord-252528-rgnhfcbx	73	5	GM	GM	NNP
cord-252528-rgnhfcbx	73	6	-	-	HYPH
cord-252528-rgnhfcbx	73	7	CSF	CSF	NNP
cord-252528-rgnhfcbx	73	8	in	in	IN
cord-252528-rgnhfcbx	73	9	regulating	regulate	VBG
cord-252528-rgnhfcbx	73	10	macrophage	macrophage	NN
cord-252528-rgnhfcbx	73	11	differentiation	differentiation	NN
cord-252528-rgnhfcbx	73	12	and	and	CC
cord-252528-rgnhfcbx	73	13	function	function	NN
cord-252528-rgnhfcbx	73	14	,	,	,
cord-252528-rgnhfcbx	73	15	GM	GM	NNP
cord-252528-rgnhfcbx	73	16	-	-	HYPH
cord-252528-rgnhfcbx	73	17	CSF	CSF	NNP
cord-252528-rgnhfcbx	73	18	can	can	MD
cord-252528-rgnhfcbx	73	19	also	also	RB
cord-252528-rgnhfcbx	73	20	up	up	RB
cord-252528-rgnhfcbx	73	21	-	-	HYPH
cord-252528-rgnhfcbx	73	22	regulate	regulate	VB
cord-252528-rgnhfcbx	73	23	the	the	DT
cord-252528-rgnhfcbx	73	24	immunological	immunological	JJ
cord-252528-rgnhfcbx	73	25	activities	activity	NNS
cord-252528-rgnhfcbx	73	26	of	of	IN
cord-252528-rgnhfcbx	73	27	neutrophils	neutrophil	NNS
cord-252528-rgnhfcbx	73	28	,	,	,
cord-252528-rgnhfcbx	73	29	including	include	VBG
cord-252528-rgnhfcbx	73	30	tissue	tissue	NN
cord-252528-rgnhfcbx	73	31	entries	entry	NNS
cord-252528-rgnhfcbx	73	32	,	,	,
cord-252528-rgnhfcbx	73	33	phagocytic	phagocytic	JJ
cord-252528-rgnhfcbx	73	34	activities	activity	NNS
cord-252528-rgnhfcbx	73	35	,	,	,
cord-252528-rgnhfcbx	73	36	and	and	CC
cord-252528-rgnhfcbx	73	37	reactive	reactive	JJ
cord-252528-rgnhfcbx	73	38	oxygen	oxygen	NN
cord-252528-rgnhfcbx	73	39	species	specie	NNS
cord-252528-rgnhfcbx	73	40	(	(	-LRB-
cord-252528-rgnhfcbx	73	41	ROS	ROS	NNP
cord-252528-rgnhfcbx	73	42	)	)	-RRB-
cord-252528-rgnhfcbx	73	43	productions	production	NNS
cord-252528-rgnhfcbx	73	44	(	(	-LRB-
cord-252528-rgnhfcbx	73	45	Fig	Fig	NNP
cord-252528-rgnhfcbx	73	46	.	.	.
cord-252528-rgnhfcbx	73	47	1	1	CD
cord-252528-rgnhfcbx	73	48	)	)	-RRB-
cord-252528-rgnhfcbx	73	49	[	[	-LRB-
cord-252528-rgnhfcbx	73	50	21	21	CD
cord-252528-rgnhfcbx	73	51	]	]	-RRB-
cord-252528-rgnhfcbx	73	52	.	.	.
cord-252528-rgnhfcbx	74	1	During	during	IN
cord-252528-rgnhfcbx	74	2	virus	virus	NN
cord-252528-rgnhfcbx	74	3	infections	infection	NNS
cord-252528-rgnhfcbx	74	4	,	,	,
cord-252528-rgnhfcbx	74	5	activated	activate	VBN
cord-252528-rgnhfcbx	74	6	T	t	NN
cord-252528-rgnhfcbx	74	7	cells	cell	NNS
cord-252528-rgnhfcbx	74	8	can	can	MD
cord-252528-rgnhfcbx	74	9	enter	enter	VB
cord-252528-rgnhfcbx	74	10	the	the	DT
cord-252528-rgnhfcbx	74	11	bone	bone	NN
cord-252528-rgnhfcbx	74	12	marrow	marrow	NN
cord-252528-rgnhfcbx	74	13	and	and	CC
cord-252528-rgnhfcbx	74	14	influence	influence	NN
cord-252528-rgnhfcbx	74	15	hematopoiesis	hematopoiesis	NN
cord-252528-rgnhfcbx	74	16	by	by	IN
cord-252528-rgnhfcbx	74	17	secreting	secrete	VBG
cord-252528-rgnhfcbx	74	18	IFN	IFN	NNP
cord-252528-rgnhfcbx	74	19	-	-	HYPH
cord-252528-rgnhfcbx	74	20	γ	γ	NNP
cord-252528-rgnhfcbx	74	21	[	[	-LRB-
cord-252528-rgnhfcbx	74	22	22	22	CD
cord-252528-rgnhfcbx	74	23	,	,	,
cord-252528-rgnhfcbx	74	24	23	23	CD
cord-252528-rgnhfcbx	74	25	]	]	-RRB-
cord-252528-rgnhfcbx	74	26	.	.	.
cord-252528-rgnhfcbx	75	1	Both	both	DT
cord-252528-rgnhfcbx	75	2	in	in	IN
cord-252528-rgnhfcbx	75	3	vitro	vitro	FW
cord-252528-rgnhfcbx	75	4	and	and	CC
cord-252528-rgnhfcbx	75	5	in	in	IN
cord-252528-rgnhfcbx	75	6	vivo	vivo	NN
cord-252528-rgnhfcbx	75	7	evidence	evidence	NN
cord-252528-rgnhfcbx	75	8	has	have	VBZ
cord-252528-rgnhfcbx	75	9	shown	show	VBN
cord-252528-rgnhfcbx	75	10	that	that	IN
cord-252528-rgnhfcbx	75	11	T	t	NN
cord-252528-rgnhfcbx	75	12	-	-	HYPH
cord-252528-rgnhfcbx	75	13	cell	cell	NN
cord-252528-rgnhfcbx	75	14	-	-	HYPH
cord-252528-rgnhfcbx	75	15	derived	derive	VBN
cord-252528-rgnhfcbx	75	16	IFN	IFN	NNP
cord-252528-rgnhfcbx	75	17	-	-	HYPH
cord-252528-rgnhfcbx	75	18	γ	γ	NN
cord-252528-rgnhfcbx	75	19	favors	favor	VBZ
cord-252528-rgnhfcbx	75	20	monocyte	monocyte	JJ
cord-252528-rgnhfcbx	75	21	differentiation	differentiation	NN
cord-252528-rgnhfcbx	75	22	over	over	IN
cord-252528-rgnhfcbx	75	23	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	75	24	differentiation	differentiation	NN
cord-252528-rgnhfcbx	75	25	during	during	IN
cord-252528-rgnhfcbx	75	26	myelopoiesis	myelopoiesis	NN
cord-252528-rgnhfcbx	75	27	in	in	IN
cord-252528-rgnhfcbx	75	28	the	the	DT
cord-252528-rgnhfcbx	75	29	bone	bone	NN
cord-252528-rgnhfcbx	75	30	marrow	marrow	NN
cord-252528-rgnhfcbx	75	31	.	.	.
cord-252528-rgnhfcbx	76	1	This	this	DT
cord-252528-rgnhfcbx	76	2	tilted	tilted	JJ
cord-252528-rgnhfcbx	76	3	balance	balance	NN
cord-252528-rgnhfcbx	76	4	of	of	IN
cord-252528-rgnhfcbx	76	5	myeloid	myeloid	JJ
cord-252528-rgnhfcbx	76	6	progenitor	progenitor	NN
cord-252528-rgnhfcbx	76	7	development	development	NN
cord-252528-rgnhfcbx	76	8	away	away	RB
cord-252528-rgnhfcbx	76	9	from	from	IN
cord-252528-rgnhfcbx	76	10	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	76	11	towards	towards	IN
cord-252528-rgnhfcbx	76	12	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	76	13	is	be	VBZ
cord-252528-rgnhfcbx	76	14	mediated	mediate	VBN
cord-252528-rgnhfcbx	76	15	by	by	IN
cord-252528-rgnhfcbx	76	16	both	both	CC
cord-252528-rgnhfcbx	76	17	IFN	IFN	NNP
cord-252528-rgnhfcbx	76	18	-	-	HYPH
cord-252528-rgnhfcbx	76	19	γ	γ	NN
cord-252528-rgnhfcbx	76	20	-	-	HYPH
cord-252528-rgnhfcbx	76	21	stimulated	stimulate	VBN
cord-252528-rgnhfcbx	76	22	expressions	expression	NNS
cord-252528-rgnhfcbx	76	23	of	of	IN
cord-252528-rgnhfcbx	76	24	PU.1	PU.1	NNP
cord-252528-rgnhfcbx	76	25	and	and	CC
cord-252528-rgnhfcbx	76	26	interferon	interferon	NN
cord-252528-rgnhfcbx	76	27	responsive	responsive	JJ
cord-252528-rgnhfcbx	76	28	factor	factor	NN
cord-252528-rgnhfcbx	76	29	8	8	CD
cord-252528-rgnhfcbx	76	30	(	(	-LRB-
cord-252528-rgnhfcbx	76	31	IRF-8	IRF-8	NNP
cord-252528-rgnhfcbx	76	32	)	)	-RRB-
cord-252528-rgnhfcbx	76	33	,	,	,
cord-252528-rgnhfcbx	76	34	which	which	WDT
cord-252528-rgnhfcbx	76	35	are	be	VBP
cord-252528-rgnhfcbx	76	36	inducers	inducer	NNS
cord-252528-rgnhfcbx	76	37	of	of	IN
cord-252528-rgnhfcbx	76	38	monocyte	monocyte	JJ
cord-252528-rgnhfcbx	76	39	differentiation	differentiation	NN
cord-252528-rgnhfcbx	76	40	,	,	,
cord-252528-rgnhfcbx	76	41	and	and	CC
cord-252528-rgnhfcbx	76	42	IFN	IFN	NNP
cord-252528-rgnhfcbx	76	43	-	-	HYPH
cord-252528-rgnhfcbx	76	44	γ	γ	NNP
cord-252528-rgnhfcbx	76	45	-	-	HYPH
cord-252528-rgnhfcbx	76	46	induced	induce	VBN
cord-252528-rgnhfcbx	76	47	activation	activation	NN
cord-252528-rgnhfcbx	76	48	of	of	IN
cord-252528-rgnhfcbx	76	49	suppressor	suppressor	NN
cord-252528-rgnhfcbx	76	50	of	of	IN
cord-252528-rgnhfcbx	76	51	cytokine	cytokine	NN
cord-252528-rgnhfcbx	76	52	signaling	signal	VBG
cord-252528-rgnhfcbx	76	53	3	3	CD
cord-252528-rgnhfcbx	76	54	(	(	-LRB-
cord-252528-rgnhfcbx	76	55	SOCS3	SOCS3	NNP
cord-252528-rgnhfcbx	76	56	)	)	-RRB-
cord-252528-rgnhfcbx	76	57	,	,	,
cord-252528-rgnhfcbx	76	58	which	which	WDT
cord-252528-rgnhfcbx	76	59	inhibits	inhibit	VBZ
cord-252528-rgnhfcbx	76	60	the	the	DT
cord-252528-rgnhfcbx	76	61	phosphorylation	phosphorylation	NN
cord-252528-rgnhfcbx	76	62	of	of	IN
cord-252528-rgnhfcbx	76	63	STAT3	STAT3	NNP
cord-252528-rgnhfcbx	76	64	in	in	IN
cord-252528-rgnhfcbx	76	65	response	response	NN
cord-252528-rgnhfcbx	76	66	to	to	IN
cord-252528-rgnhfcbx	76	67	G	G	NNP
cord-252528-rgnhfcbx	76	68	-	-	HYPH
cord-252528-rgnhfcbx	76	69	CSF	CSF	NNP
cord-252528-rgnhfcbx	76	70	,	,	,
cord-252528-rgnhfcbx	76	71	in	in	IN
cord-252528-rgnhfcbx	76	72	granulocyte	granulocyte	NN
cord-252528-rgnhfcbx	76	73	-	-	HYPH
cord-252528-rgnhfcbx	76	74	macrophage	macrophage	NN
cord-252528-rgnhfcbx	76	75	progenitors	progenitor	NNS
cord-252528-rgnhfcbx	76	76	(	(	-LRB-
cord-252528-rgnhfcbx	76	77	Fig	Fig	NNP
cord-252528-rgnhfcbx	76	78	.	.	.
cord-252528-rgnhfcbx	76	79	1	1	CD
cord-252528-rgnhfcbx	76	80	)	)	-RRB-
cord-252528-rgnhfcbx	77	1	[	[	-LRB-
cord-252528-rgnhfcbx	77	2	24	24	CD
cord-252528-rgnhfcbx	77	3	]	]	-RRB-
cord-252528-rgnhfcbx	77	4	.	.	.
cord-252528-rgnhfcbx	78	1	IFN	IFN	NNP
cord-252528-rgnhfcbx	78	2	-	-	HYPH
cord-252528-rgnhfcbx	78	3	γ	γ	NNP
cord-252528-rgnhfcbx	78	4	can	can	MD
cord-252528-rgnhfcbx	78	5	also	also	RB
cord-252528-rgnhfcbx	78	6	skew	skew	VB
cord-252528-rgnhfcbx	78	7	the	the	DT
cord-252528-rgnhfcbx	78	8	development	development	NN
cord-252528-rgnhfcbx	78	9	of	of	IN
cord-252528-rgnhfcbx	78	10	multipotent	multipotent	JJ
cord-252528-rgnhfcbx	78	11	hematopoietic	hematopoietic	JJ
cord-252528-rgnhfcbx	78	12	progenitors	progenitor	NNS
cord-252528-rgnhfcbx	78	13	to	to	IN
cord-252528-rgnhfcbx	78	14	the	the	DT
cord-252528-rgnhfcbx	78	15	monocytic	monocytic	JJ
cord-252528-rgnhfcbx	78	16	lineage	lineage	NN
cord-252528-rgnhfcbx	78	17	in	in	IN
cord-252528-rgnhfcbx	78	18	an	an	DT
cord-252528-rgnhfcbx	78	19	indirect	indirect	JJ
cord-252528-rgnhfcbx	78	20	manner	manner	NN
cord-252528-rgnhfcbx	78	21	by	by	IN
cord-252528-rgnhfcbx	78	22	stimulating	stimulate	VBG
cord-252528-rgnhfcbx	78	23	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	78	24	production	production	NN
cord-252528-rgnhfcbx	78	25	in	in	IN
cord-252528-rgnhfcbx	78	26	the	the	DT
cord-252528-rgnhfcbx	78	27	bone	bone	NN
cord-252528-rgnhfcbx	78	28	marrow	marrow	NN
cord-252528-rgnhfcbx	78	29	mesenchymal	mesenchymal	VBG
cord-252528-rgnhfcbx	78	30	stem	stem	NN
cord-252528-rgnhfcbx	78	31	cells	cell	NNS
cord-252528-rgnhfcbx	78	32	[	[	-LRB-
cord-252528-rgnhfcbx	78	33	25	25	CD
cord-252528-rgnhfcbx	78	34	]	]	-RRB-
cord-252528-rgnhfcbx	78	35	.	.	.
cord-252528-rgnhfcbx	79	1	Moreover	moreover	RB
cord-252528-rgnhfcbx	79	2	,	,	,
cord-252528-rgnhfcbx	79	3	in	in	IN
cord-252528-rgnhfcbx	79	4	response	response	NN
cord-252528-rgnhfcbx	79	5	to	to	IN
cord-252528-rgnhfcbx	79	6	IFN	IFN	NNP
cord-252528-rgnhfcbx	79	7	-	-	HYPH
cord-252528-rgnhfcbx	79	8	γ	γ	NNP
cord-252528-rgnhfcbx	79	9	,	,	,
cord-252528-rgnhfcbx	79	10	the	the	DT
cord-252528-rgnhfcbx	79	11	production	production	NN
cord-252528-rgnhfcbx	79	12	of	of	IN
cord-252528-rgnhfcbx	79	13	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	79	14	in	in	IN
cord-252528-rgnhfcbx	79	15	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	79	16	is	be	VBZ
cord-252528-rgnhfcbx	79	17	also	also	RB
cord-252528-rgnhfcbx	79	18	positively	positively	RB
cord-252528-rgnhfcbx	79	19	regulated	regulate	VBN
cord-252528-rgnhfcbx	79	20	through	through	IN
cord-252528-rgnhfcbx	79	21	direct	direct	JJ
cord-252528-rgnhfcbx	79	22	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	79	23	promoter	promoter	NN
cord-252528-rgnhfcbx	79	24	binding	bind	VBG
cord-252528-rgnhfcbx	79	25	by	by	IN
cord-252528-rgnhfcbx	79	26	Notch1	Notch1	NNP
cord-252528-rgnhfcbx	80	1	[	[	-LRB-
cord-252528-rgnhfcbx	80	2	26	26	CD
cord-252528-rgnhfcbx	80	3	]	]	-RRB-
cord-252528-rgnhfcbx	80	4	.	.	.
cord-252528-rgnhfcbx	81	1	When	when	WRB
cord-252528-rgnhfcbx	81	2	encountering	encounter	VBG
cord-252528-rgnhfcbx	81	3	the	the	DT
cord-252528-rgnhfcbx	81	4	novel	novel	JJ
cord-252528-rgnhfcbx	81	5	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	81	6	,	,	,
cord-252528-rgnhfcbx	81	7	the	the	DT
cord-252528-rgnhfcbx	81	8	immune	immune	JJ
cord-252528-rgnhfcbx	81	9	system	system	NN
cord-252528-rgnhfcbx	81	10	displays	display	VBZ
cord-252528-rgnhfcbx	81	11	low	low	JJ
cord-252528-rgnhfcbx	81	12	efficacy	efficacy	NN
cord-252528-rgnhfcbx	81	13	for	for	IN
cord-252528-rgnhfcbx	81	14	virus	virus	NN
cord-252528-rgnhfcbx	81	15	clearance	clearance	NN
cord-252528-rgnhfcbx	81	16	[	[	-LRB-
cord-252528-rgnhfcbx	81	17	13	13	CD
cord-252528-rgnhfcbx	81	18	,	,	,
cord-252528-rgnhfcbx	81	19	14	14	CD
cord-252528-rgnhfcbx	81	20	]	]	-RRB-
cord-252528-rgnhfcbx	81	21	.	.	.
cord-252528-rgnhfcbx	82	1	Constantly	constantly	RB
cord-252528-rgnhfcbx	82	2	exposed	expose	VBN
cord-252528-rgnhfcbx	82	3	to	to	IN
cord-252528-rgnhfcbx	82	4	the	the	DT
cord-252528-rgnhfcbx	82	5	viral	viral	JJ
cord-252528-rgnhfcbx	82	6	pathogen	pathogen	NN
cord-252528-rgnhfcbx	82	7	,	,	,
cord-252528-rgnhfcbx	82	8	the	the	DT
cord-252528-rgnhfcbx	82	9	immune	immune	JJ
cord-252528-rgnhfcbx	82	10	system	system	NN
cord-252528-rgnhfcbx	82	11	may	may	MD
cord-252528-rgnhfcbx	82	12	initiate	initiate	VB
cord-252528-rgnhfcbx	82	13	a	a	DT
cord-252528-rgnhfcbx	82	14	continuous	continuous	JJ
cord-252528-rgnhfcbx	82	15	systemic	systemic	JJ
cord-252528-rgnhfcbx	82	16	inflammation	inflammation	NN
cord-252528-rgnhfcbx	82	17	through	through	IN
cord-252528-rgnhfcbx	82	18	GM	GM	NNP
cord-252528-rgnhfcbx	82	19	-	-	HYPH
cord-252528-rgnhfcbx	82	20	CSF	CSF	NNP
cord-252528-rgnhfcbx	82	21	and	and	CC
cord-252528-rgnhfcbx	82	22	IFN	IFN	NNP
cord-252528-rgnhfcbx	82	23	-	-	HYPH
cord-252528-rgnhfcbx	82	24	γ	γ	NN
cord-252528-rgnhfcbx	82	25	production	production	NN
cord-252528-rgnhfcbx	82	26	by	by	IN
cord-252528-rgnhfcbx	82	27	T	t	NN
cord-252528-rgnhfcbx	82	28	cells	cell	NNS
cord-252528-rgnhfcbx	82	29	.	.	.
cord-252528-rgnhfcbx	83	1	GM	GM	NNP
cord-252528-rgnhfcbx	83	2	-	-	HYPH
cord-252528-rgnhfcbx	83	3	CSF	CSF	NNP
cord-252528-rgnhfcbx	83	4	and	and	CC
cord-252528-rgnhfcbx	83	5	IFN	IFN	NNP
cord-252528-rgnhfcbx	83	6	-	-	HYPH
cord-252528-rgnhfcbx	83	7	γ	γ	NNP
cord-252528-rgnhfcbx	83	8	could	could	MD
cord-252528-rgnhfcbx	83	9	promote	promote	VB
cord-252528-rgnhfcbx	83	10	both	both	CC
cord-252528-rgnhfcbx	83	11	the	the	DT
cord-252528-rgnhfcbx	83	12	function	function	NN
cord-252528-rgnhfcbx	83	13	and	and	CC
cord-252528-rgnhfcbx	83	14	the	the	DT
cord-252528-rgnhfcbx	83	15	production	production	NN
cord-252528-rgnhfcbx	83	16	of	of	IN
cord-252528-rgnhfcbx	83	17	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	83	18	.	.	.
cord-252528-rgnhfcbx	84	1	Activated	activate	VBN
cord-252528-rgnhfcbx	84	2	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	84	3	could	could	MD
cord-252528-rgnhfcbx	84	4	further	further	RB
cord-252528-rgnhfcbx	84	5	continue	continue	VB
cord-252528-rgnhfcbx	84	6	the	the	DT
cord-252528-rgnhfcbx	84	7	vicious	vicious	JJ
cord-252528-rgnhfcbx	84	8	cycle	cycle	NN
cord-252528-rgnhfcbx	84	9	of	of	IN
cord-252528-rgnhfcbx	84	10	excessive	excessive	JJ
cord-252528-rgnhfcbx	84	11	systemic	systemic	JJ
cord-252528-rgnhfcbx	84	12	inflammation	inflammation	NN
cord-252528-rgnhfcbx	84	13	by	by	IN
cord-252528-rgnhfcbx	84	14	promoting	promote	VBG
cord-252528-rgnhfcbx	84	15	the	the	DT
cord-252528-rgnhfcbx	84	16	production	production	NN
cord-252528-rgnhfcbx	84	17	and	and	CC
cord-252528-rgnhfcbx	84	18	immunological	immunological	JJ
cord-252528-rgnhfcbx	84	19	activities	activity	NNS
cord-252528-rgnhfcbx	84	20	of	of	IN
cord-252528-rgnhfcbx	84	21	itself	-PRON-	PRP
cord-252528-rgnhfcbx	84	22	through	through	IN
cord-252528-rgnhfcbx	84	23	GM	GM	NNP
cord-252528-rgnhfcbx	84	24	-	-	HYPH
cord-252528-rgnhfcbx	84	25	CSF	csf	NN
cord-252528-rgnhfcbx	84	26	secretion	secretion	NN
cord-252528-rgnhfcbx	84	27	(	(	-LRB-
cord-252528-rgnhfcbx	84	28	Fig	Fig	NNP
cord-252528-rgnhfcbx	84	29	.	.	.
cord-252528-rgnhfcbx	84	30	1	1	CD
cord-252528-rgnhfcbx	84	31	)	)	-RRB-
cord-252528-rgnhfcbx	84	32	[	[	-LRB-
cord-252528-rgnhfcbx	84	33	6	6	CD
cord-252528-rgnhfcbx	84	34	]	]	-RRB-
cord-252528-rgnhfcbx	84	35	.	.	.
cord-252528-rgnhfcbx	85	1	The	the	DT
cord-252528-rgnhfcbx	85	2	excessive	excessive	JJ
cord-252528-rgnhfcbx	85	3	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	85	4	response	response	NN
cord-252528-rgnhfcbx	85	5	in	in	IN
cord-252528-rgnhfcbx	85	6	severe	severe	JJ
cord-252528-rgnhfcbx	85	7	patients	patient	NNS
cord-252528-rgnhfcbx	85	8	,	,	,
cord-252528-rgnhfcbx	85	9	potentially	potentially	RB
cord-252528-rgnhfcbx	85	10	attributed	attribute	VBN
cord-252528-rgnhfcbx	85	11	to	to	IN
cord-252528-rgnhfcbx	85	12	unresolved	unresolved	JJ
cord-252528-rgnhfcbx	85	13	virus	virus	NN
cord-252528-rgnhfcbx	85	14	infection	infection	NN
cord-252528-rgnhfcbx	85	15	,	,	,
cord-252528-rgnhfcbx	85	16	could	could	MD
cord-252528-rgnhfcbx	85	17	eventually	eventually	RB
cord-252528-rgnhfcbx	85	18	result	result	VB
cord-252528-rgnhfcbx	85	19	in	in	IN
cord-252528-rgnhfcbx	85	20	T	T	NNP
cord-252528-rgnhfcbx	85	21	cell	cell	NN
cord-252528-rgnhfcbx	85	22	depletion	depletion	NN
cord-252528-rgnhfcbx	85	23	.	.	.
cord-252528-rgnhfcbx	86	1	In	in	IN
cord-252528-rgnhfcbx	86	2	accordance	accordance	NN
cord-252528-rgnhfcbx	86	3	,	,	,
cord-252528-rgnhfcbx	86	4	a	a	DT
cord-252528-rgnhfcbx	86	5	high	high	JJ
cord-252528-rgnhfcbx	86	6	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	86	7	to	to	IN
cord-252528-rgnhfcbx	86	8	CD8	CD8	NNP
cord-252528-rgnhfcbx	86	9	+	+	CC
cord-252528-rgnhfcbx	86	10	T	T	NNP
cord-252528-rgnhfcbx	86	11	cell	cell	NN
cord-252528-rgnhfcbx	86	12	ratio	ratio	NN
cord-252528-rgnhfcbx	86	13	(	(	-LRB-
cord-252528-rgnhfcbx	86	14	N8R	n8r	CD
cord-252528-rgnhfcbx	86	15	)	)	-RRB-
cord-252528-rgnhfcbx	86	16	in	in	IN
cord-252528-rgnhfcbx	86	17	the	the	DT
cord-252528-rgnhfcbx	86	18	blood	blood	NN
cord-252528-rgnhfcbx	86	19	has	have	VBZ
cord-252528-rgnhfcbx	86	20	been	be	VBN
cord-252528-rgnhfcbx	86	21	suggested	suggest	VBN
cord-252528-rgnhfcbx	86	22	to	to	TO
cord-252528-rgnhfcbx	86	23	predict	predict	VB
cord-252528-rgnhfcbx	86	24	a	a	DT
cord-252528-rgnhfcbx	86	25	worse	bad	JJR
cord-252528-rgnhfcbx	86	26	prognosis	prognosis	NN
cord-252528-rgnhfcbx	86	27	in	in	IN
cord-252528-rgnhfcbx	86	28	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	86	29	patients	patient	NNS
cord-252528-rgnhfcbx	86	30	[	[	-LRB-
cord-252528-rgnhfcbx	86	31	5	5	CD
cord-252528-rgnhfcbx	86	32	]	]	-RRB-
cord-252528-rgnhfcbx	86	33	.	.	.
cord-252528-rgnhfcbx	87	1	This	this	DT
cord-252528-rgnhfcbx	87	2	observation	observation	NN
cord-252528-rgnhfcbx	87	3	might	may	MD
cord-252528-rgnhfcbx	87	4	be	be	VB
cord-252528-rgnhfcbx	87	5	explained	explain	VBN
cord-252528-rgnhfcbx	87	6	by	by	IN
cord-252528-rgnhfcbx	87	7	the	the	DT
cord-252528-rgnhfcbx	87	8	T	T	NNP
cord-252528-rgnhfcbx	87	9	cell	cell	NN
cord-252528-rgnhfcbx	87	10	depletion	depletion	NN
cord-252528-rgnhfcbx	87	11	in	in	IN
cord-252528-rgnhfcbx	87	12	severe	severe	JJ
cord-252528-rgnhfcbx	87	13	patients	patient	NNS
cord-252528-rgnhfcbx	87	14	,	,	,
cord-252528-rgnhfcbx	87	15	in	in	IN
cord-252528-rgnhfcbx	87	16	conjunction	conjunction	NN
cord-252528-rgnhfcbx	87	17	with	with	IN
cord-252528-rgnhfcbx	87	18	the	the	DT
cord-252528-rgnhfcbx	87	19	role	role	NN
cord-252528-rgnhfcbx	87	20	of	of	IN
cord-252528-rgnhfcbx	87	21	IFN	IFN	NNP
cord-252528-rgnhfcbx	87	22	-	-	HYPH
cord-252528-rgnhfcbx	87	23	γ	γ	NNP
cord-252528-rgnhfcbx	87	24	,	,	,
cord-252528-rgnhfcbx	87	25	secreted	secrete	VBN
cord-252528-rgnhfcbx	87	26	by	by	IN
cord-252528-rgnhfcbx	87	27	T	T	NNP
cord-252528-rgnhfcbx	87	28	Fig	Fig	NNP
cord-252528-rgnhfcbx	87	29	.	.	.
cord-252528-rgnhfcbx	88	1	1	1	CD
cord-252528-rgnhfcbx	88	2	Schematic	Schematic	NNP
cord-252528-rgnhfcbx	88	3	diagram	diagram	NN
cord-252528-rgnhfcbx	88	4	showing	show	VBG
cord-252528-rgnhfcbx	88	5	the	the	DT
cord-252528-rgnhfcbx	88	6	immuno	immuno	JJ
cord-252528-rgnhfcbx	88	7	-	-	JJ
cord-252528-rgnhfcbx	88	8	pathological	pathological	JJ
cord-252528-rgnhfcbx	88	9	basis	basis	NN
cord-252528-rgnhfcbx	88	10	of	of	IN
cord-252528-rgnhfcbx	88	11	excessive	excessive	JJ
cord-252528-rgnhfcbx	88	12	cytokine	cytokine	NN
cord-252528-rgnhfcbx	88	13	release	release	NN
cord-252528-rgnhfcbx	88	14	in	in	IN
cord-252528-rgnhfcbx	88	15	severe	severe	JJ
cord-252528-rgnhfcbx	88	16	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	88	17	patients	patient	NNS
cord-252528-rgnhfcbx	88	18	.	.	.
cord-252528-rgnhfcbx	89	1	SARS	SARS	NNP
cord-252528-rgnhfcbx	89	2	-	-	HYPH
cord-252528-rgnhfcbx	89	3	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	89	4	severe	severe	JJ
cord-252528-rgnhfcbx	89	5	acute	acute	JJ
cord-252528-rgnhfcbx	89	6	respiratory	respiratory	JJ
cord-252528-rgnhfcbx	89	7	syndrome	syndrome	NN
cord-252528-rgnhfcbx	89	8	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	89	9	type	type	NN
cord-252528-rgnhfcbx	89	10	2	2	CD
cord-252528-rgnhfcbx	89	11	,	,	,
cord-252528-rgnhfcbx	89	12	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	89	13	interleukin-6	interleukin-6	NNP
cord-252528-rgnhfcbx	89	14	,	,	,
cord-252528-rgnhfcbx	90	1	GM	GM	NNP
cord-252528-rgnhfcbx	90	2	-	-	HYPH
cord-252528-rgnhfcbx	90	3	CSF	CSF	NNP
cord-252528-rgnhfcbx	90	4	granulocytemacrophage	granulocytemacrophage	NN
cord-252528-rgnhfcbx	90	5	colony	colony	NN
cord-252528-rgnhfcbx	90	6	-	-	HYPH
cord-252528-rgnhfcbx	90	7	stimulating	stimulate	VBG
cord-252528-rgnhfcbx	90	8	factor	factor	NN
cord-252528-rgnhfcbx	90	9	,	,	,
cord-252528-rgnhfcbx	90	10	IFN	IFN	NNP
cord-252528-rgnhfcbx	90	11	-	-	HYPH
cord-252528-rgnhfcbx	90	12	γ	γ	NNP
cord-252528-rgnhfcbx	90	13	interferon	interferon	NN
cord-252528-rgnhfcbx	90	14	γ	γ	NN
cord-252528-rgnhfcbx	90	15	,	,	,
cord-252528-rgnhfcbx	90	16	GMP	GMP	NNP
cord-252528-rgnhfcbx	90	17	granulocyte	granulocyte	NN
cord-252528-rgnhfcbx	90	18	-	-	HYPH
cord-252528-rgnhfcbx	90	19	macrophage	macrophage	NN
cord-252528-rgnhfcbx	90	20	progenitor	progenitor	NN
cord-252528-rgnhfcbx	90	21	,	,	,
cord-252528-rgnhfcbx	90	22	SOCS3	socs3	JJ
cord-252528-rgnhfcbx	90	23	suppressor	suppressor	NN
cord-252528-rgnhfcbx	90	24	of	of	IN
cord-252528-rgnhfcbx	90	25	cytokine	cytokine	NN
cord-252528-rgnhfcbx	90	26	signaling	signal	VBG
cord-252528-rgnhfcbx	90	27	3	3	CD
cord-252528-rgnhfcbx	90	28	,	,	,
cord-252528-rgnhfcbx	90	29	G	G	NNP
cord-252528-rgnhfcbx	90	30	-	-	HYPH
cord-252528-rgnhfcbx	90	31	CSF	csf	NN
cord-252528-rgnhfcbx	90	32	granulocyte	granulocyte	NN
cord-252528-rgnhfcbx	90	33	-	-	HYPH
cord-252528-rgnhfcbx	90	34	colony	colony	NN
cord-252528-rgnhfcbx	90	35	stimulating	stimulate	VBG
cord-252528-rgnhfcbx	90	36	factor	factor	NN
cord-252528-rgnhfcbx	90	37	,	,	,
cord-252528-rgnhfcbx	90	38	IRF-8	IRF-8	NNP
cord-252528-rgnhfcbx	90	39	interferon	interferon	NN
cord-252528-rgnhfcbx	90	40	responsive	responsive	JJ
cord-252528-rgnhfcbx	90	41	factor	factor	NN
cord-252528-rgnhfcbx	90	42	8	8	CD
cord-252528-rgnhfcbx	90	43	cells	cell	NNS
cord-252528-rgnhfcbx	90	44	,	,	,
cord-252528-rgnhfcbx	90	45	in	in	IN
cord-252528-rgnhfcbx	90	46	favoring	favor	VBG
cord-252528-rgnhfcbx	90	47	monocytes	monocytes	JJ
cord-252528-rgnhfcbx	90	48	differentiation	differentiation	NN
cord-252528-rgnhfcbx	90	49	versus	versus	IN
cord-252528-rgnhfcbx	90	50	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	90	51	differentiation	differentiation	NN
cord-252528-rgnhfcbx	90	52	in	in	IN
cord-252528-rgnhfcbx	90	53	the	the	DT
cord-252528-rgnhfcbx	90	54	bone	bone	NN
cord-252528-rgnhfcbx	90	55	marrow	marrow	NN
cord-252528-rgnhfcbx	90	56	during	during	IN
cord-252528-rgnhfcbx	90	57	virus	virus	NN
cord-252528-rgnhfcbx	90	58	infections	infection	NNS
cord-252528-rgnhfcbx	90	59	.	.	.
cord-252528-rgnhfcbx	91	1	Age	age	NN
cord-252528-rgnhfcbx	91	2	and	and	CC
cord-252528-rgnhfcbx	91	3	human	human	JJ
cord-252528-rgnhfcbx	91	4	leucocyte	leucocyte	NN
cord-252528-rgnhfcbx	91	5	antigen	antigen	NNP
cord-252528-rgnhfcbx	91	6	(	(	-LRB-
cord-252528-rgnhfcbx	91	7	HLA	HLA	NNP
cord-252528-rgnhfcbx	91	8	)	)	-RRB-
cord-252528-rgnhfcbx	91	9	polymorphisms	polymorphism	NNS
cord-252528-rgnhfcbx	91	10	can	can	MD
cord-252528-rgnhfcbx	91	11	be	be	VB
cord-252528-rgnhfcbx	91	12	factors	factor	NNS
cord-252528-rgnhfcbx	91	13	that	that	WDT
cord-252528-rgnhfcbx	91	14	predispose	predispose	VBP
cord-252528-rgnhfcbx	91	15	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	91	16	patients	patient	NNS
cord-252528-rgnhfcbx	91	17	to	to	IN
cord-252528-rgnhfcbx	91	18	prolonged	prolonged	JJ
cord-252528-rgnhfcbx	91	19	and	and	CC
cord-252528-rgnhfcbx	91	20	excessive	excessive	JJ
cord-252528-rgnhfcbx	91	21	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	91	22	.	.	.
cord-252528-rgnhfcbx	92	1	An	an	DT
cord-252528-rgnhfcbx	92	2	aged	aged	JJ
cord-252528-rgnhfcbx	92	3	immune	immune	JJ
cord-252528-rgnhfcbx	92	4	system	system	NN
cord-252528-rgnhfcbx	92	5	is	be	VBZ
cord-252528-rgnhfcbx	92	6	not	not	RB
cord-252528-rgnhfcbx	92	7	only	only	RB
cord-252528-rgnhfcbx	92	8	associated	associate	VBN
cord-252528-rgnhfcbx	92	9	with	with	IN
cord-252528-rgnhfcbx	92	10	a	a	DT
cord-252528-rgnhfcbx	92	11	decreased	decrease	VBN
cord-252528-rgnhfcbx	92	12	efficiency	efficiency	NN
cord-252528-rgnhfcbx	92	13	for	for	IN
cord-252528-rgnhfcbx	92	14	virus	virus	NN
cord-252528-rgnhfcbx	92	15	clearance	clearance	NN
cord-252528-rgnhfcbx	92	16	due	due	JJ
cord-252528-rgnhfcbx	92	17	to	to	IN
cord-252528-rgnhfcbx	92	18	declined	decline	VBD
cord-252528-rgnhfcbx	92	19	B	B	NNP
cord-252528-rgnhfcbx	92	20	and	and	CC
cord-252528-rgnhfcbx	92	21	T	T	NNP
cord-252528-rgnhfcbx	92	22	cell	cell	NN
cord-252528-rgnhfcbx	92	23	productions	production	NNS
cord-252528-rgnhfcbx	92	24	and	and	CC
cord-252528-rgnhfcbx	92	25	functions	function	NNS
cord-252528-rgnhfcbx	92	26	,	,	,
cord-252528-rgnhfcbx	92	27	leading	lead	VBG
cord-252528-rgnhfcbx	92	28	to	to	IN
cord-252528-rgnhfcbx	92	29	constant	constant	JJ
cord-252528-rgnhfcbx	92	30	viral	viral	JJ
cord-252528-rgnhfcbx	92	31	exposure	exposure	NN
cord-252528-rgnhfcbx	92	32	and	and	CC
cord-252528-rgnhfcbx	92	33	excessive	excessive	JJ
cord-252528-rgnhfcbx	92	34	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	92	35	,	,	,
cord-252528-rgnhfcbx	92	36	but	but	CC
cord-252528-rgnhfcbx	92	37	also	also	RB
cord-252528-rgnhfcbx	92	38	associated	associate	VBN
cord-252528-rgnhfcbx	92	39	with	with	IN
cord-252528-rgnhfcbx	92	40	an	an	DT
cord-252528-rgnhfcbx	92	41	increased	increase	VBN
cord-252528-rgnhfcbx	92	42	propensity	propensity	NN
cord-252528-rgnhfcbx	92	43	for	for	IN
cord-252528-rgnhfcbx	92	44	excessive	excessive	JJ
cord-252528-rgnhfcbx	92	45	pro	pro	JJ
cord-252528-rgnhfcbx	92	46	-	-	JJ
cord-252528-rgnhfcbx	92	47	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	92	48	cytokine	cytokine	NN
cord-252528-rgnhfcbx	92	49	release	release	NN
cord-252528-rgnhfcbx	92	50	because	because	IN
cord-252528-rgnhfcbx	92	51	of	of	IN
cord-252528-rgnhfcbx	92	52	reduced	reduce	VBN
cord-252528-rgnhfcbx	92	53	productions	production	NNS
cord-252528-rgnhfcbx	92	54	of	of	IN
cord-252528-rgnhfcbx	92	55	the	the	DT
cord-252528-rgnhfcbx	92	56	immunosuppressive	immunosuppressive	JJ
cord-252528-rgnhfcbx	92	57	thymusderived	thymusderive	VBN
cord-252528-rgnhfcbx	92	58	regulatory	regulatory	JJ
cord-252528-rgnhfcbx	92	59	T	T	NNP
cord-252528-rgnhfcbx	92	60	cells	cell	NNS
cord-252528-rgnhfcbx	92	61	(	(	-LRB-
cord-252528-rgnhfcbx	92	62	Tregs	Tregs	NNP
cord-252528-rgnhfcbx	92	63	)	)	-RRB-
cord-252528-rgnhfcbx	92	64	[	[	-LRB-
cord-252528-rgnhfcbx	92	65	27	27	CD
cord-252528-rgnhfcbx	92	66	,	,	,
cord-252528-rgnhfcbx	92	67	28	28	CD
cord-252528-rgnhfcbx	92	68	]	]	-RRB-
cord-252528-rgnhfcbx	92	69	.	.	.
cord-252528-rgnhfcbx	93	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	93	2	,	,	,
cord-252528-rgnhfcbx	93	3	HLA	HLA	NNP
cord-252528-rgnhfcbx	93	4	displays	display	VBZ
cord-252528-rgnhfcbx	93	5	extensive	extensive	JJ
cord-252528-rgnhfcbx	93	6	polymorphisms	polymorphism	NNS
cord-252528-rgnhfcbx	93	7	,	,	,
cord-252528-rgnhfcbx	93	8	and	and	CC
cord-252528-rgnhfcbx	93	9	is	be	VBZ
cord-252528-rgnhfcbx	93	10	crucial	crucial	JJ
cord-252528-rgnhfcbx	93	11	for	for	IN
cord-252528-rgnhfcbx	93	12	the	the	DT
cord-252528-rgnhfcbx	93	13	immune	immune	JJ
cord-252528-rgnhfcbx	93	14	response	response	NN
cord-252528-rgnhfcbx	93	15	to	to	IN
cord-252528-rgnhfcbx	93	16	viral	viral	JJ
cord-252528-rgnhfcbx	93	17	antigens	antigen	NNS
cord-252528-rgnhfcbx	93	18	.	.	.
cord-252528-rgnhfcbx	94	1	SARS	SARS	NNP
cord-252528-rgnhfcbx	94	2	-	-	HYPH
cord-252528-rgnhfcbx	94	3	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	94	4	infection	infection	NN
cord-252528-rgnhfcbx	94	5	may	may	MD
cord-252528-rgnhfcbx	94	6	be	be	VB
cord-252528-rgnhfcbx	94	7	similar	similar	JJ
cord-252528-rgnhfcbx	94	8	to	to	IN
cord-252528-rgnhfcbx	94	9	other	other	JJ
cord-252528-rgnhfcbx	94	10	types	type	NNS
cord-252528-rgnhfcbx	94	11	of	of	IN
cord-252528-rgnhfcbx	94	12	virus	virus	NN
cord-252528-rgnhfcbx	94	13	infection	infection	NN
cord-252528-rgnhfcbx	94	14	,	,	,
cord-252528-rgnhfcbx	94	15	where	where	WRB
cord-252528-rgnhfcbx	94	16	associations	association	NNS
cord-252528-rgnhfcbx	94	17	can	can	MD
cord-252528-rgnhfcbx	94	18	exist	exist	VB
cord-252528-rgnhfcbx	94	19	between	between	IN
cord-252528-rgnhfcbx	94	20	certain	certain	JJ
cord-252528-rgnhfcbx	94	21	HLA	HLA	NNP
cord-252528-rgnhfcbx	94	22	haplotypes	haplotype	NNS
cord-252528-rgnhfcbx	94	23	and	and	CC
cord-252528-rgnhfcbx	94	24	disease	disease	NN
cord-252528-rgnhfcbx	94	25	severity	severity	NN
cord-252528-rgnhfcbx	94	26	[	[	-LRB-
cord-252528-rgnhfcbx	94	27	29	29	CD
cord-252528-rgnhfcbx	94	28	]	]	-RRB-
cord-252528-rgnhfcbx	94	29	.	.	.
cord-252528-rgnhfcbx	95	1	Certain	certain	JJ
cord-252528-rgnhfcbx	95	2	HLA	HLA	NNP
cord-252528-rgnhfcbx	95	3	haplotypes	haplotype	NNS
cord-252528-rgnhfcbx	95	4	might	may	MD
cord-252528-rgnhfcbx	95	5	predispose	predispose	VB
cord-252528-rgnhfcbx	95	6	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	95	7	patients	patient	NNS
cord-252528-rgnhfcbx	95	8	to	to	IN
cord-252528-rgnhfcbx	95	9	a	a	DT
cord-252528-rgnhfcbx	95	10	more	more	RBR
cord-252528-rgnhfcbx	95	11	excessive	excessive	JJ
cord-252528-rgnhfcbx	95	12	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	95	13	response	response	NN
cord-252528-rgnhfcbx	95	14	.	.	.
cord-252528-rgnhfcbx	96	1	Future	future	JJ
cord-252528-rgnhfcbx	96	2	genetic	genetic	JJ
cord-252528-rgnhfcbx	96	3	sequencing	sequencing	NN
cord-252528-rgnhfcbx	96	4	studies	study	NNS
cord-252528-rgnhfcbx	96	5	are	be	VBP
cord-252528-rgnhfcbx	96	6	required	require	VBN
cord-252528-rgnhfcbx	96	7	to	to	TO
cord-252528-rgnhfcbx	96	8	understand	understand	VB
cord-252528-rgnhfcbx	96	9	this	this	DT
cord-252528-rgnhfcbx	96	10	association	association	NN
cord-252528-rgnhfcbx	96	11	,	,	,
cord-252528-rgnhfcbx	96	12	which	which	WDT
cord-252528-rgnhfcbx	96	13	can	can	MD
cord-252528-rgnhfcbx	96	14	guide	guide	VB
cord-252528-rgnhfcbx	96	15	the	the	DT
cord-252528-rgnhfcbx	96	16	treatment	treatment	NN
cord-252528-rgnhfcbx	96	17	and	and	CC
cord-252528-rgnhfcbx	96	18	management	management	NN
cord-252528-rgnhfcbx	96	19	of	of	IN
cord-252528-rgnhfcbx	96	20	patients	patient	NNS
cord-252528-rgnhfcbx	96	21	in	in	IN
cord-252528-rgnhfcbx	96	22	the	the	DT
cord-252528-rgnhfcbx	96	23	clinic	clinic	NN
cord-252528-rgnhfcbx	96	24	,	,	,
cord-252528-rgnhfcbx	96	25	as	as	RB
cord-252528-rgnhfcbx	96	26	well	well	RB
cord-252528-rgnhfcbx	96	27	as	as	IN
cord-252528-rgnhfcbx	96	28	vaccine	vaccine	NN
cord-252528-rgnhfcbx	96	29	productions	production	NNS
cord-252528-rgnhfcbx	96	30	.	.	.
cord-252528-rgnhfcbx	97	1	Early	early	JJ
cord-252528-rgnhfcbx	97	2	anti	anti	JJ
cord-252528-rgnhfcbx	97	3	-	-	JJ
cord-252528-rgnhfcbx	97	4	viral	viral	JJ
cord-252528-rgnhfcbx	97	5	immune	immune	JJ
cord-252528-rgnhfcbx	97	6	responses	response	NNS
cord-252528-rgnhfcbx	97	7	can	can	MD
cord-252528-rgnhfcbx	97	8	facilitate	facilitate	VB
cord-252528-rgnhfcbx	97	9	the	the	DT
cord-252528-rgnhfcbx	97	10	clearance	clearance	NN
cord-252528-rgnhfcbx	97	11	of	of	IN
cord-252528-rgnhfcbx	97	12	pathogens	pathogen	NNS
cord-252528-rgnhfcbx	97	13	;	;	:
cord-252528-rgnhfcbx	97	14	however	however	RB
cord-252528-rgnhfcbx	97	15	,	,	,
cord-252528-rgnhfcbx	97	16	the	the	DT
cord-252528-rgnhfcbx	97	17	prolonged	prolonged	JJ
cord-252528-rgnhfcbx	97	18	and	and	CC
cord-252528-rgnhfcbx	97	19	excessive	excessive	JJ
cord-252528-rgnhfcbx	97	20	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	97	21	activities	activity	NNS
cord-252528-rgnhfcbx	97	22	,	,	,
cord-252528-rgnhfcbx	97	23	observed	observe	VBN
cord-252528-rgnhfcbx	97	24	in	in	IN
cord-252528-rgnhfcbx	97	25	severe	severe	JJ
cord-252528-rgnhfcbx	97	26	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	97	27	patients	patient	NNS
cord-252528-rgnhfcbx	97	28	,	,	,
cord-252528-rgnhfcbx	97	29	can	can	MD
cord-252528-rgnhfcbx	97	30	result	result	VB
cord-252528-rgnhfcbx	97	31	in	in	IN
cord-252528-rgnhfcbx	97	32	tissue	tissue	NN
cord-252528-rgnhfcbx	97	33	damage	damage	NN
cord-252528-rgnhfcbx	97	34	and	and	CC
cord-252528-rgnhfcbx	97	35	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	97	36	state	state	NN
cord-252528-rgnhfcbx	97	37	.	.	.
cord-252528-rgnhfcbx	98	1	Differences	difference	NNS
cord-252528-rgnhfcbx	98	2	in	in	IN
cord-252528-rgnhfcbx	98	3	standards	standard	NNS
cord-252528-rgnhfcbx	98	4	for	for	IN
cord-252528-rgnhfcbx	98	5	severe	severe	JJ
cord-252528-rgnhfcbx	98	6	illness	illness	NN
cord-252528-rgnhfcbx	98	7	and	and	CC
cord-252528-rgnhfcbx	98	8	variations	variation	NNS
cord-252528-rgnhfcbx	98	9	in	in	IN
cord-252528-rgnhfcbx	98	10	health	health	NN
cord-252528-rgnhfcbx	98	11	conditions	condition	NNS
cord-252528-rgnhfcbx	98	12	among	among	IN
cord-252528-rgnhfcbx	98	13	patients	patient	NNS
cord-252528-rgnhfcbx	98	14	may	may	MD
cord-252528-rgnhfcbx	98	15	lead	lead	VB
cord-252528-rgnhfcbx	98	16	to	to	IN
cord-252528-rgnhfcbx	98	17	discrepancies	discrepancy	NNS
cord-252528-rgnhfcbx	98	18	of	of	IN
cord-252528-rgnhfcbx	98	19	the	the	DT
cord-252528-rgnhfcbx	98	20	results	result	NNS
cord-252528-rgnhfcbx	98	21	from	from	IN
cord-252528-rgnhfcbx	98	22	different	different	JJ
cord-252528-rgnhfcbx	98	23	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	98	24	clinical	clinical	JJ
cord-252528-rgnhfcbx	98	25	studies	study	NNS
cord-252528-rgnhfcbx	98	26	that	that	WDT
cord-252528-rgnhfcbx	98	27	compare	compare	VBP
cord-252528-rgnhfcbx	98	28	serum	serum	NN
cord-252528-rgnhfcbx	98	29	levels	level	NNS
cord-252528-rgnhfcbx	98	30	of	of	IN
cord-252528-rgnhfcbx	98	31	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	98	32	between	between	IN
cord-252528-rgnhfcbx	98	33	mild	mild	JJ
cord-252528-rgnhfcbx	98	34	and	and	CC
cord-252528-rgnhfcbx	98	35	severe	severe	JJ
cord-252528-rgnhfcbx	98	36	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	98	37	patients	patient	NNS
cord-252528-rgnhfcbx	98	38	.	.	.
cord-252528-rgnhfcbx	99	1	However	however	RB
cord-252528-rgnhfcbx	99	2	,	,	,
cord-252528-rgnhfcbx	99	3	most	most	JJS
cord-252528-rgnhfcbx	99	4	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	99	5	clinical	clinical	JJ
cord-252528-rgnhfcbx	99	6	studies	study	NNS
cord-252528-rgnhfcbx	99	7	so	so	RB
cord-252528-rgnhfcbx	99	8	far	far	RB
cord-252528-rgnhfcbx	99	9	have	have	VBP
cord-252528-rgnhfcbx	99	10	consistently	consistently	RB
cord-252528-rgnhfcbx	99	11	displayed	display	VBN
cord-252528-rgnhfcbx	99	12	enhanced	enhanced	JJ
cord-252528-rgnhfcbx	99	13	serum	serum	NN
cord-252528-rgnhfcbx	99	14	levels	level	NNS
cord-252528-rgnhfcbx	99	15	of	of	IN
cord-252528-rgnhfcbx	99	16	pro	pro	JJ
cord-252528-rgnhfcbx	99	17	-	-	JJ
cord-252528-rgnhfcbx	99	18	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	99	19	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	99	20	,	,	,
cord-252528-rgnhfcbx	99	21	including	include	VBG
cord-252528-rgnhfcbx	99	22	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	99	23	,	,	,
cord-252528-rgnhfcbx	99	24	Th1related	th1relate	VBD
cord-252528-rgnhfcbx	99	25	IFN	IFN	NNP
cord-252528-rgnhfcbx	99	26	-	-	HYPH
cord-252528-rgnhfcbx	99	27	γ	γ	NNP
cord-252528-rgnhfcbx	99	28	,	,	,
cord-252528-rgnhfcbx	99	29	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	99	30	along	along	IN
cord-252528-rgnhfcbx	99	31	with	with	IN
cord-252528-rgnhfcbx	99	32	increased	increase	VBN
cord-252528-rgnhfcbx	99	33	serum	serum	NN
cord-252528-rgnhfcbx	99	34	levels	level	NNS
cord-252528-rgnhfcbx	99	35	of	of	IN
cord-252528-rgnhfcbx	99	36	the	the	DT
cord-252528-rgnhfcbx	99	37	anti	anti	JJ
cord-252528-rgnhfcbx	99	38	-	-	JJ
cord-252528-rgnhfcbx	99	39	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	99	40	cytokine	cytokine	NN
cord-252528-rgnhfcbx	99	41	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	99	42	in	in	IN
cord-252528-rgnhfcbx	99	43	severe	severe	JJ
cord-252528-rgnhfcbx	99	44	patients	patient	NNS
cord-252528-rgnhfcbx	99	45	,	,	,
cord-252528-rgnhfcbx	99	46	in	in	IN
cord-252528-rgnhfcbx	99	47	comparison	comparison	NN
cord-252528-rgnhfcbx	99	48	with	with	IN
cord-252528-rgnhfcbx	99	49	the	the	DT
cord-252528-rgnhfcbx	99	50	serum	serum	NN
cord-252528-rgnhfcbx	99	51	levels	level	NNS
cord-252528-rgnhfcbx	99	52	of	of	IN
cord-252528-rgnhfcbx	99	53	these	these	DT
cord-252528-rgnhfcbx	99	54	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	99	55	in	in	IN
cord-252528-rgnhfcbx	99	56	mild	mild	JJ
cord-252528-rgnhfcbx	99	57	patients	patient	NNS
cord-252528-rgnhfcbx	99	58	[	[	-LRB-
cord-252528-rgnhfcbx	99	59	2	2	CD
cord-252528-rgnhfcbx	99	60	]	]	-RRB-
cord-252528-rgnhfcbx	99	61	[	[	-LRB-
cord-252528-rgnhfcbx	99	62	3	3	CD
cord-252528-rgnhfcbx	99	63	]	]	-RRB-
cord-252528-rgnhfcbx	99	64	[	[	-LRB-
cord-252528-rgnhfcbx	99	65	4	4	CD
cord-252528-rgnhfcbx	99	66	]	]	-RRB-
cord-252528-rgnhfcbx	99	67	[	[	-LRB-
cord-252528-rgnhfcbx	99	68	5	5	CD
cord-252528-rgnhfcbx	99	69	]	]	-RRB-
cord-252528-rgnhfcbx	99	70	[	[	-LRB-
cord-252528-rgnhfcbx	99	71	6	6	CD
cord-252528-rgnhfcbx	99	72	]	]	-RRB-
cord-252528-rgnhfcbx	99	73	.	.	.
cord-252528-rgnhfcbx	100	1	Based	base	VBN
cord-252528-rgnhfcbx	100	2	on	on	IN
cord-252528-rgnhfcbx	100	3	previous	previous	JJ
cord-252528-rgnhfcbx	100	4	experimental	experimental	JJ
cord-252528-rgnhfcbx	100	5	and	and	CC
cord-252528-rgnhfcbx	100	6	clinical	clinical	JJ
cord-252528-rgnhfcbx	100	7	evidence	evidence	NN
cord-252528-rgnhfcbx	100	8	,	,	,
cord-252528-rgnhfcbx	100	9	generally	generally	RB
cord-252528-rgnhfcbx	100	10	,	,	,
cord-252528-rgnhfcbx	100	11	the	the	DT
cord-252528-rgnhfcbx	100	12	pro	pro	JJ
cord-252528-rgnhfcbx	100	13	-	-	JJ
cord-252528-rgnhfcbx	100	14	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	100	15	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	100	16	,	,	,
cord-252528-rgnhfcbx	100	17	including	include	VBG
cord-252528-rgnhfcbx	100	18	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	100	19	,	,	,
cord-252528-rgnhfcbx	100	20	IFN	IFN	NNP
cord-252528-rgnhfcbx	100	21	-	-	HYPH
cord-252528-rgnhfcbx	100	22	γ	γ	NNP
cord-252528-rgnhfcbx	100	23	,	,	,
cord-252528-rgnhfcbx	100	24	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	100	25	,	,	,
cord-252528-rgnhfcbx	100	26	can	can	MD
cord-252528-rgnhfcbx	100	27	promote	promote	VB
cord-252528-rgnhfcbx	100	28	a	a	DT
cord-252528-rgnhfcbx	100	29	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	100	30	state	state	NN
cord-252528-rgnhfcbx	100	31	in	in	IN
cord-252528-rgnhfcbx	100	32	favor	favor	NN
cord-252528-rgnhfcbx	100	33	of	of	IN
cord-252528-rgnhfcbx	100	34	thrombus	thrombus	NN
cord-252528-rgnhfcbx	100	35	formation	formation	NN
cord-252528-rgnhfcbx	100	36	,	,	,
cord-252528-rgnhfcbx	100	37	whereas	whereas	IN
cord-252528-rgnhfcbx	100	38	the	the	DT
cord-252528-rgnhfcbx	100	39	anti	anti	JJ
cord-252528-rgnhfcbx	100	40	-	-	JJ
cord-252528-rgnhfcbx	100	41	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	100	42	cytokine	cytokine	NN
cord-252528-rgnhfcbx	100	43	,	,	,
cord-252528-rgnhfcbx	100	44	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	100	45	,	,	,
cord-252528-rgnhfcbx	100	46	conducts	conduct	VBZ
cord-252528-rgnhfcbx	100	47	anti	anti	JJ
cord-252528-rgnhfcbx	100	48	-	-	JJ
cord-252528-rgnhfcbx	100	49	coagulative	coagulative	JJ
cord-252528-rgnhfcbx	100	50	activities	activity	NNS
cord-252528-rgnhfcbx	100	51	which	which	WDT
cord-252528-rgnhfcbx	100	52	prevent	prevent	VBP
cord-252528-rgnhfcbx	100	53	vascular	vascular	JJ
cord-252528-rgnhfcbx	100	54	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	100	55	events	event	NNS
cord-252528-rgnhfcbx	100	56	(	(	-LRB-
cord-252528-rgnhfcbx	100	57	Fig	Fig	NNP
cord-252528-rgnhfcbx	100	58	.	.	NNP
cord-252528-rgnhfcbx	100	59	2	2	CD
cord-252528-rgnhfcbx	100	60	)	)	-RRB-
cord-252528-rgnhfcbx	100	61	.	.	.
cord-252528-rgnhfcbx	101	1	In	in	IN
cord-252528-rgnhfcbx	101	2	severe	severe	JJ
cord-252528-rgnhfcbx	101	3	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	101	4	,	,	,
cord-252528-rgnhfcbx	101	5	the	the	DT
cord-252528-rgnhfcbx	101	6	excessive	excessive	JJ
cord-252528-rgnhfcbx	101	7	pro	pro	JJ
cord-252528-rgnhfcbx	101	8	-	-	JJ
cord-252528-rgnhfcbx	101	9	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	101	10	cytokine	cytokine	NN
cord-252528-rgnhfcbx	101	11	release	release	NN
cord-252528-rgnhfcbx	101	12	can	can	MD
cord-252528-rgnhfcbx	101	13	contribute	contribute	VB
cord-252528-rgnhfcbx	101	14	to	to	IN
cord-252528-rgnhfcbx	101	15	the	the	DT
cord-252528-rgnhfcbx	101	16	activation	activation	NN
cord-252528-rgnhfcbx	101	17	of	of	IN
cord-252528-rgnhfcbx	101	18	coagulation	coagulation	NN
cord-252528-rgnhfcbx	101	19	cascade	cascade	NN
cord-252528-rgnhfcbx	101	20	.	.	.
cord-252528-rgnhfcbx	102	1	Thrombin	Thrombin	NNP
cord-252528-rgnhfcbx	102	2	,	,	,
cord-252528-rgnhfcbx	102	3	an	an	DT
cord-252528-rgnhfcbx	102	4	essential	essential	JJ
cord-252528-rgnhfcbx	102	5	candidate	candidate	NN
cord-252528-rgnhfcbx	102	6	in	in	IN
cord-252528-rgnhfcbx	102	7	the	the	DT
cord-252528-rgnhfcbx	102	8	coagulation	coagulation	NN
cord-252528-rgnhfcbx	102	9	cascade	cascade	NN
cord-252528-rgnhfcbx	102	10	,	,	,
cord-252528-rgnhfcbx	102	11	not	not	RB
cord-252528-rgnhfcbx	102	12	only	only	RB
cord-252528-rgnhfcbx	102	13	mediates	mediate	VBZ
cord-252528-rgnhfcbx	102	14	the	the	DT
cord-252528-rgnhfcbx	102	15	blood	blood	NN
cord-252528-rgnhfcbx	102	16	clot	clot	NN
cord-252528-rgnhfcbx	102	17	formation	formation	NN
cord-252528-rgnhfcbx	102	18	by	by	IN
cord-252528-rgnhfcbx	102	19	converting	convert	VBG
cord-252528-rgnhfcbx	102	20	fibrinogen	fibrinogen	NN
cord-252528-rgnhfcbx	102	21	to	to	IN
cord-252528-rgnhfcbx	102	22	fibrin	fibrin	NN
cord-252528-rgnhfcbx	102	23	,	,	,
cord-252528-rgnhfcbx	102	24	but	but	CC
cord-252528-rgnhfcbx	102	25	also	also	RB
cord-252528-rgnhfcbx	102	26	can	can	MD
cord-252528-rgnhfcbx	102	27	act	act	VB
cord-252528-rgnhfcbx	102	28	on	on	IN
cord-252528-rgnhfcbx	102	29	the	the	DT
cord-252528-rgnhfcbx	102	30	proteinase	proteinase	NN
cord-252528-rgnhfcbx	102	31	-	-	HYPH
cord-252528-rgnhfcbx	102	32	activated	activate	VBN
cord-252528-rgnhfcbx	102	33	receptors	receptor	NNS
cord-252528-rgnhfcbx	102	34	to	to	TO
cord-252528-rgnhfcbx	102	35	amplify	amplify	VB
cord-252528-rgnhfcbx	102	36	the	the	DT
cord-252528-rgnhfcbx	102	37	inflammation	inflammation	NN
cord-252528-rgnhfcbx	102	38	in	in	IN
cord-252528-rgnhfcbx	102	39	a	a	DT
cord-252528-rgnhfcbx	102	40	positive	positive	JJ
cord-252528-rgnhfcbx	102	41	feedback	feedback	NN
cord-252528-rgnhfcbx	102	42	manner	manner	NN
cord-252528-rgnhfcbx	102	43	[	[	-LRB-
cord-252528-rgnhfcbx	102	44	30	30	CD
cord-252528-rgnhfcbx	102	45	]	]	-RRB-
cord-252528-rgnhfcbx	102	46	.	.	.
cord-252528-rgnhfcbx	103	1	The	the	DT
cord-252528-rgnhfcbx	103	2	presence	presence	NN
cord-252528-rgnhfcbx	103	3	of	of	IN
cord-252528-rgnhfcbx	103	4	positive	positive	JJ
cord-252528-rgnhfcbx	103	5	regulations	regulation	NNS
cord-252528-rgnhfcbx	103	6	between	between	IN
cord-252528-rgnhfcbx	103	7	inflammation	inflammation	NN
cord-252528-rgnhfcbx	103	8	and	and	CC
cord-252528-rgnhfcbx	103	9	coagulation	coagulation	NN
cord-252528-rgnhfcbx	103	10	may	may	MD
cord-252528-rgnhfcbx	103	11	explain	explain	VB
cord-252528-rgnhfcbx	103	12	the	the	DT
cord-252528-rgnhfcbx	103	13	concurrent	concurrent	JJ
cord-252528-rgnhfcbx	103	14	existence	existence	NN
cord-252528-rgnhfcbx	103	15	of	of	IN
cord-252528-rgnhfcbx	103	16	excessive	excessive	JJ
cord-252528-rgnhfcbx	103	17	pro	pro	JJ
cord-252528-rgnhfcbx	103	18	-	-	JJ
cord-252528-rgnhfcbx	103	19	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	103	20	cytokine	cytokine	NN
cord-252528-rgnhfcbx	103	21	release	release	NN
cord-252528-rgnhfcbx	103	22	and	and	CC
cord-252528-rgnhfcbx	103	23	serum	serum	NN
cord-252528-rgnhfcbx	103	24	markers	marker	NNS
cord-252528-rgnhfcbx	103	25	of	of	IN
cord-252528-rgnhfcbx	103	26	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	103	27	state	state	NN
cord-252528-rgnhfcbx	103	28	in	in	IN
cord-252528-rgnhfcbx	103	29	severe	severe	JJ
cord-252528-rgnhfcbx	103	30	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	103	31	patients	patient	NNS
cord-252528-rgnhfcbx	103	32	.	.	.
cord-252528-rgnhfcbx	104	1	Although	although	IN
cord-252528-rgnhfcbx	104	2	the	the	DT
cord-252528-rgnhfcbx	104	3	excessive	excessive	JJ
cord-252528-rgnhfcbx	104	4	pro	pro	JJ
cord-252528-rgnhfcbx	104	5	-	-	JJ
cord-252528-rgnhfcbx	104	6	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	104	7	cytokine	cytokine	NN
cord-252528-rgnhfcbx	104	8	release	release	NN
cord-252528-rgnhfcbx	104	9	in	in	IN
cord-252528-rgnhfcbx	104	10	severe	severe	JJ
cord-252528-rgnhfcbx	104	11	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	104	12	patients	patient	NNS
cord-252528-rgnhfcbx	104	13	can	can	MD
cord-252528-rgnhfcbx	104	14	promote	promote	VB
cord-252528-rgnhfcbx	104	15	vascular	vascular	JJ
cord-252528-rgnhfcbx	104	16	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	104	17	through	through	IN
cord-252528-rgnhfcbx	104	18	complicated	complicated	JJ
cord-252528-rgnhfcbx	104	19	interplays	interplay	NNS
cord-252528-rgnhfcbx	104	20	with	with	IN
cord-252528-rgnhfcbx	104	21	factors	factor	NNS
cord-252528-rgnhfcbx	104	22	that	that	WDT
cord-252528-rgnhfcbx	104	23	participate	participate	VBP
cord-252528-rgnhfcbx	104	24	in	in	IN
cord-252528-rgnhfcbx	104	25	the	the	DT
cord-252528-rgnhfcbx	104	26	blood	blood	NN
cord-252528-rgnhfcbx	104	27	coagulation	coagulation	NN
cord-252528-rgnhfcbx	104	28	,	,	,
cord-252528-rgnhfcbx	104	29	it	-PRON-	PRP
cord-252528-rgnhfcbx	104	30	might	may	MD
cord-252528-rgnhfcbx	104	31	not	not	RB
cord-252528-rgnhfcbx	104	32	be	be	VB
cord-252528-rgnhfcbx	104	33	the	the	DT
cord-252528-rgnhfcbx	104	34	only	only	JJ
cord-252528-rgnhfcbx	104	35	etiology	etiology	NN
cord-252528-rgnhfcbx	104	36	of	of	IN
cord-252528-rgnhfcbx	104	37	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	104	38	state	state	NN
cord-252528-rgnhfcbx	104	39	and	and	CC
cord-252528-rgnhfcbx	104	40	vascular	vascular	JJ
cord-252528-rgnhfcbx	104	41	thrombus	thrombus	NN
cord-252528-rgnhfcbx	104	42	formation	formation	NN
cord-252528-rgnhfcbx	104	43	in	in	IN
cord-252528-rgnhfcbx	104	44	severe	severe	JJ
cord-252528-rgnhfcbx	104	45	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	104	46	.	.	.
cord-252528-rgnhfcbx	105	1	A	a	DT
cord-252528-rgnhfcbx	105	2	recent	recent	JJ
cord-252528-rgnhfcbx	105	3	autopsy	autopsy	JJ
cord-252528-rgnhfcbx	105	4	study	study	NN
cord-252528-rgnhfcbx	105	5	has	have	VBZ
cord-252528-rgnhfcbx	105	6	demonstrated	demonstrate	VBN
cord-252528-rgnhfcbx	105	7	that	that	IN
cord-252528-rgnhfcbx	105	8	SARS	SARS	NNP
cord-252528-rgnhfcbx	105	9	-	-	HYPH
cord-252528-rgnhfcbx	105	10	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	105	11	can	can	MD
cord-252528-rgnhfcbx	105	12	directly	directly	RB
cord-252528-rgnhfcbx	105	13	invade	invade	VB
cord-252528-rgnhfcbx	105	14	and	and	CC
cord-252528-rgnhfcbx	105	15	damage	damage	VB
cord-252528-rgnhfcbx	105	16	vascular	vascular	JJ
cord-252528-rgnhfcbx	105	17	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	105	18	cell	cell	NN
cord-252528-rgnhfcbx	105	19	(	(	-LRB-
cord-252528-rgnhfcbx	105	20	EC	EC	NNP
cord-252528-rgnhfcbx	105	21	)	)	-RRB-
cord-252528-rgnhfcbx	105	22	,	,	,
cord-252528-rgnhfcbx	105	23	as	as	IN
cord-252528-rgnhfcbx	105	24	evidenced	evidence	VBN
cord-252528-rgnhfcbx	105	25	by	by	IN
cord-252528-rgnhfcbx	105	26	the	the	DT
cord-252528-rgnhfcbx	105	27	presence	presence	NN
cord-252528-rgnhfcbx	105	28	of	of	IN
cord-252528-rgnhfcbx	105	29	viral	viral	JJ
cord-252528-rgnhfcbx	105	30	inclusions	inclusion	NNS
cord-252528-rgnhfcbx	105	31	inside	inside	IN
cord-252528-rgnhfcbx	105	32	the	the	DT
cord-252528-rgnhfcbx	105	33	vascular	vascular	JJ
cord-252528-rgnhfcbx	105	34	ECs	ec	NNS
cord-252528-rgnhfcbx	105	35	in	in	IN
cord-252528-rgnhfcbx	105	36	the	the	DT
cord-252528-rgnhfcbx	105	37	histological	histological	JJ
cord-252528-rgnhfcbx	105	38	analyses	analysis	NNS
cord-252528-rgnhfcbx	105	39	[	[	-LRB-
cord-252528-rgnhfcbx	105	40	31	31	CD
cord-252528-rgnhfcbx	105	41	]	]	-RRB-
cord-252528-rgnhfcbx	105	42	.	.	.
cord-252528-rgnhfcbx	106	1	Besides	besides	RB
cord-252528-rgnhfcbx	106	2	,	,	,
cord-252528-rgnhfcbx	106	3	aggregation	aggregation	NN
cord-252528-rgnhfcbx	106	4	of	of	IN
cord-252528-rgnhfcbx	106	5	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	106	6	leukocytes	leukocyte	NNS
cord-252528-rgnhfcbx	106	7	around	around	IN
cord-252528-rgnhfcbx	106	8	vascular	vascular	JJ
cord-252528-rgnhfcbx	106	9	ECs	ec	NNS
cord-252528-rgnhfcbx	106	10	has	have	VBZ
cord-252528-rgnhfcbx	106	11	also	also	RB
cord-252528-rgnhfcbx	106	12	been	be	VBN
cord-252528-rgnhfcbx	106	13	detected	detect	VBN
cord-252528-rgnhfcbx	106	14	in	in	IN
cord-252528-rgnhfcbx	106	15	the	the	DT
cord-252528-rgnhfcbx	106	16	histological	histological	JJ
cord-252528-rgnhfcbx	106	17	analyses	analysis	NNS
cord-252528-rgnhfcbx	106	18	,	,	,
cord-252528-rgnhfcbx	106	19	indicating	indicate	VBG
cord-252528-rgnhfcbx	106	20	that	that	IN
cord-252528-rgnhfcbx	106	21	SARS	SARS	NNP
cord-252528-rgnhfcbx	106	22	-	-	HYPH
cord-252528-rgnhfcbx	106	23	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	106	24	can	can	MD
cord-252528-rgnhfcbx	106	25	possibly	possibly	RB
cord-252528-rgnhfcbx	106	26	induce	induce	VB
cord-252528-rgnhfcbx	106	27	vascular	vascular	JJ
cord-252528-rgnhfcbx	106	28	endothelitis	endothelitis	NN
cord-252528-rgnhfcbx	106	29	by	by	IN
cord-252528-rgnhfcbx	106	30	directly	directly	RB
cord-252528-rgnhfcbx	106	31	invading	invade	VBG
cord-252528-rgnhfcbx	106	32	ECs	ECs	NNP
cord-252528-rgnhfcbx	106	33	,	,	,
cord-252528-rgnhfcbx	106	34	facilitating	facilitate	VBG
cord-252528-rgnhfcbx	106	35	vascular	vascular	JJ
cord-252528-rgnhfcbx	106	36	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	106	37	[	[	-LRB-
cord-252528-rgnhfcbx	106	38	31	31	CD
cord-252528-rgnhfcbx	106	39	]	]	-RRB-
cord-252528-rgnhfcbx	106	40	.	.	.
cord-252528-rgnhfcbx	107	1	Therefore	therefore	RB
cord-252528-rgnhfcbx	107	2	,	,	,
cord-252528-rgnhfcbx	107	3	the	the	DT
cord-252528-rgnhfcbx	107	4	significance	significance	NN
cord-252528-rgnhfcbx	107	5	of	of	IN
cord-252528-rgnhfcbx	107	6	excessive	excessive	JJ
cord-252528-rgnhfcbx	107	7	pro	pro	JJ
cord-252528-rgnhfcbx	107	8	-	-	JJ
cord-252528-rgnhfcbx	107	9	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	107	10	cytokine	cytokine	NN
cord-252528-rgnhfcbx	107	11	release	release	NN
cord-252528-rgnhfcbx	107	12	as	as	IN
cord-252528-rgnhfcbx	107	13	an	an	DT
cord-252528-rgnhfcbx	107	14	etiology	etiology	NN
cord-252528-rgnhfcbx	107	15	of	of	IN
cord-252528-rgnhfcbx	107	16	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	107	17	state	state	NN
cord-252528-rgnhfcbx	107	18	and	and	CC
cord-252528-rgnhfcbx	107	19	thrombus	thrombus	NN
cord-252528-rgnhfcbx	107	20	formation	formation	NN
cord-252528-rgnhfcbx	107	21	in	in	IN
cord-252528-rgnhfcbx	107	22	severe	severe	JJ
cord-252528-rgnhfcbx	107	23	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	107	24	should	should	MD
cord-252528-rgnhfcbx	107	25	be	be	VB
cord-252528-rgnhfcbx	107	26	further	further	RB
cord-252528-rgnhfcbx	107	27	assessed	assess	VBN
cord-252528-rgnhfcbx	107	28	in	in	IN
cord-252528-rgnhfcbx	107	29	future	future	JJ
cord-252528-rgnhfcbx	107	30	experimental	experimental	JJ
cord-252528-rgnhfcbx	107	31	studies	study	NNS
cord-252528-rgnhfcbx	107	32	.	.	.
cord-252528-rgnhfcbx	108	1	According	accord	VBG
cord-252528-rgnhfcbx	108	2	to	to	IN
cord-252528-rgnhfcbx	108	3	the	the	DT
cord-252528-rgnhfcbx	108	4	previously	previously	RB
cord-252528-rgnhfcbx	108	5	described	describe	VBN
cord-252528-rgnhfcbx	108	6	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	108	7	of	of	IN
cord-252528-rgnhfcbx	108	8	the	the	DT
cord-252528-rgnhfcbx	108	9	dynamically	dynamically	RB
cord-252528-rgnhfcbx	108	10	changing	change	VBG
cord-252528-rgnhfcbx	108	11	cytokine	cytokine	NN
cord-252528-rgnhfcbx	108	12	profiles	profile	NNS
cord-252528-rgnhfcbx	108	13	,	,	,
cord-252528-rgnhfcbx	108	14	in	in	IN
cord-252528-rgnhfcbx	108	15	severe	severe	JJ
cord-252528-rgnhfcbx	108	16	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	108	17	patients	patient	NNS
cord-252528-rgnhfcbx	108	18	,	,	,
cord-252528-rgnhfcbx	108	19	enhanced	enhance	VBN
cord-252528-rgnhfcbx	108	20	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	108	21	and	and	CC
cord-252528-rgnhfcbx	108	22	IFN	IFN	NNP
cord-252528-rgnhfcbx	108	23	-	-	HYPH
cord-252528-rgnhfcbx	108	24	γ	γ	NN
cord-252528-rgnhfcbx	108	25	serum	serum	NN
cord-252528-rgnhfcbx	108	26	levels	level	NNS
cord-252528-rgnhfcbx	108	27	persist	persist	VBP
cord-252528-rgnhfcbx	108	28	only	only	RB
cord-252528-rgnhfcbx	108	29	for	for	IN
cord-252528-rgnhfcbx	108	30	the	the	DT
cord-252528-rgnhfcbx	108	31	first	first	JJ
cord-252528-rgnhfcbx	108	32	7	7	CD
cord-252528-rgnhfcbx	108	33	-	-	SYM
cord-252528-rgnhfcbx	108	34	9	9	CD
cord-252528-rgnhfcbx	108	35	days	day	NNS
cord-252528-rgnhfcbx	108	36	following	follow	VBG
cord-252528-rgnhfcbx	108	37	disease	disease	NN
cord-252528-rgnhfcbx	108	38	onset	onset	NN
cord-252528-rgnhfcbx	108	39	,	,	,
cord-252528-rgnhfcbx	108	40	whereas	whereas	IN
cord-252528-rgnhfcbx	108	41	the	the	DT
cord-252528-rgnhfcbx	108	42	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	108	43	serum	serum	NN
cord-252528-rgnhfcbx	108	44	level	level	NN
cord-252528-rgnhfcbx	108	45	is	be	VBZ
cord-252528-rgnhfcbx	108	46	continuously	continuously	RB
cord-252528-rgnhfcbx	108	47	elevated	elevate	VBN
cord-252528-rgnhfcbx	108	48	throughout	throughout	IN
cord-252528-rgnhfcbx	108	49	the	the	DT
cord-252528-rgnhfcbx	108	50	whole	whole	JJ
cord-252528-rgnhfcbx	108	51	course	course	NN
cord-252528-rgnhfcbx	108	52	of	of	IN
cord-252528-rgnhfcbx	108	53	the	the	DT
cord-252528-rgnhfcbx	108	54	disease	disease	NN
cord-252528-rgnhfcbx	108	55	[	[	-LRB-
cord-252528-rgnhfcbx	108	56	5	5	CD
cord-252528-rgnhfcbx	108	57	]	]	-RRB-
cord-252528-rgnhfcbx	108	58	.	.	.
cord-252528-rgnhfcbx	109	1	Hence	hence	RB
cord-252528-rgnhfcbx	109	2	,	,	,
cord-252528-rgnhfcbx	109	3	in	in	IN
cord-252528-rgnhfcbx	109	4	severe	severe	JJ
cord-252528-rgnhfcbx	109	5	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	109	6	,	,	,
cord-252528-rgnhfcbx	109	7	enhanced	enhanced	JJ
cord-252528-rgnhfcbx	109	8	serum	serum	NN
cord-252528-rgnhfcbx	109	9	levels	level	NNS
cord-252528-rgnhfcbx	109	10	of	of	IN
cord-252528-rgnhfcbx	109	11	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	109	12	and	and	CC
cord-252528-rgnhfcbx	109	13	IFN	IFN	NNP
cord-252528-rgnhfcbx	109	14	-	-	HYPH
cord-252528-rgnhfcbx	109	15	γ	γ	NNP
cord-252528-rgnhfcbx	109	16	could	could	MD
cord-252528-rgnhfcbx	109	17	be	be	VB
cord-252528-rgnhfcbx	109	18	a	a	DT
cord-252528-rgnhfcbx	109	19	trigger	trigger	NN
cord-252528-rgnhfcbx	109	20	for	for	IN
cord-252528-rgnhfcbx	109	21	the	the	DT
cord-252528-rgnhfcbx	109	22	elevation	elevation	NN
cord-252528-rgnhfcbx	109	23	in	in	IN
cord-252528-rgnhfcbx	109	24	serum	serum	NN
cord-252528-rgnhfcbx	109	25	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	109	26	level	level	NN
cord-252528-rgnhfcbx	109	27	by	by	IN
cord-252528-rgnhfcbx	109	28	increasing	increase	VBG
cord-252528-rgnhfcbx	109	29	macrophage	macrophage	NN
cord-252528-rgnhfcbx	109	30	differentiation	differentiation	NN
cord-252528-rgnhfcbx	109	31	and	and	CC
cord-252528-rgnhfcbx	109	32	activation	activation	NN
cord-252528-rgnhfcbx	109	33	(	(	-LRB-
cord-252528-rgnhfcbx	109	34	Fig	Fig	NNP
cord-252528-rgnhfcbx	109	35	.	.	.
cord-252528-rgnhfcbx	109	36	1	1	CD
cord-252528-rgnhfcbx	109	37	)	)	-RRB-
cord-252528-rgnhfcbx	109	38	.	.	.
cord-252528-rgnhfcbx	110	1	The	the	DT
cord-252528-rgnhfcbx	110	2	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	110	3	by	by	IN
cord-252528-rgnhfcbx	110	4	which	which	WDT
cord-252528-rgnhfcbx	110	5	the	the	DT
cord-252528-rgnhfcbx	110	6	pro	pro	JJ
cord-252528-rgnhfcbx	110	7	-	-	JJ
cord-252528-rgnhfcbx	110	8	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	110	9	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	110	10	,	,	,
cord-252528-rgnhfcbx	110	11	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	110	12	,	,	,
cord-252528-rgnhfcbx	110	13	IFN	IFN	NNP
cord-252528-rgnhfcbx	110	14	-	-	HYPH
cord-252528-rgnhfcbx	110	15	γ	γ	NNP
cord-252528-rgnhfcbx	110	16	,	,	,
cord-252528-rgnhfcbx	110	17	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	110	18	,	,	,
cord-252528-rgnhfcbx	110	19	and	and	CC
cord-252528-rgnhfcbx	110	20	the	the	DT
cord-252528-rgnhfcbx	110	21	anti	anti	JJ
cord-252528-rgnhfcbx	110	22	-	-	JJ
cord-252528-rgnhfcbx	110	23	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	110	24	cytokine	cytokine	NN
cord-252528-rgnhfcbx	110	25	,	,	,
cord-252528-rgnhfcbx	110	26	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	110	27	,	,	,
cord-252528-rgnhfcbx	110	28	affect	affect	VB
cord-252528-rgnhfcbx	110	29	the	the	DT
cord-252528-rgnhfcbx	110	30	coagulable	coagulable	JJ
cord-252528-rgnhfcbx	110	31	state	state	NN
cord-252528-rgnhfcbx	110	32	are	be	VBP
cord-252528-rgnhfcbx	110	33	interpreted	interpret	VBN
cord-252528-rgnhfcbx	110	34	in	in	IN
cord-252528-rgnhfcbx	110	35	detail	detail	NN
cord-252528-rgnhfcbx	110	36	subsequently	subsequently	RB
cord-252528-rgnhfcbx	110	37	.	.	.
cord-252528-rgnhfcbx	111	1	The	the	DT
cord-252528-rgnhfcbx	111	2	order	order	NN
cord-252528-rgnhfcbx	111	3	of	of	IN
cord-252528-rgnhfcbx	111	4	discussion	discussion	NN
cord-252528-rgnhfcbx	111	5	on	on	IN
cord-252528-rgnhfcbx	111	6	the	the	DT
cord-252528-rgnhfcbx	111	7	proinflammatory	proinflammatory	JJ
cord-252528-rgnhfcbx	111	8	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	111	9	is	be	VBZ
cord-252528-rgnhfcbx	111	10	arranged	arrange	VBN
cord-252528-rgnhfcbx	111	11	based	base	VBN
cord-252528-rgnhfcbx	111	12	on	on	IN
cord-252528-rgnhfcbx	111	13	the	the	DT
cord-252528-rgnhfcbx	111	14	potential	potential	JJ
cord-252528-rgnhfcbx	111	15	course	course	NN
cord-252528-rgnhfcbx	111	16	of	of	IN
cord-252528-rgnhfcbx	111	17	sequence	sequence	NN
cord-252528-rgnhfcbx	111	18	by	by	IN
cord-252528-rgnhfcbx	111	19	which	which	WDT
cord-252528-rgnhfcbx	111	20	their	-PRON-	PRP$
cord-252528-rgnhfcbx	111	21	release	release	NN
cord-252528-rgnhfcbx	111	22	is	be	VBZ
cord-252528-rgnhfcbx	111	23	triggered	trigger	VBN
cord-252528-rgnhfcbx	111	24	during	during	IN
cord-252528-rgnhfcbx	111	25	the	the	DT
cord-252528-rgnhfcbx	111	26	over	over	RB
cord-252528-rgnhfcbx	111	27	-	-	HYPH
cord-252528-rgnhfcbx	111	28	activated	activate	VBN
cord-252528-rgnhfcbx	111	29	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	111	30	response	response	NN
cord-252528-rgnhfcbx	111	31	associated	associate	VBN
cord-252528-rgnhfcbx	111	32	with	with	IN
cord-252528-rgnhfcbx	111	33	severe	severe	JJ
cord-252528-rgnhfcbx	111	34	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	111	35	.	.	.
cord-252528-rgnhfcbx	112	1	The	the	DT
cord-252528-rgnhfcbx	112	2	excessive	excessive	JJ
cord-252528-rgnhfcbx	112	3	release	release	NN
cord-252528-rgnhfcbx	112	4	of	of	IN
cord-252528-rgnhfcbx	112	5	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	112	6	,	,	,
cord-252528-rgnhfcbx	112	7	IFN	IFN	NNP
cord-252528-rgnhfcbx	112	8	-	-	HYPH
cord-252528-rgnhfcbx	112	9	γ	γ	NNP
cord-252528-rgnhfcbx	112	10	,	,	,
cord-252528-rgnhfcbx	112	11	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	112	12	,	,	,
cord-252528-rgnhfcbx	112	13	and	and	CC
cord-252528-rgnhfcbx	112	14	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	112	15	in	in	IN
cord-252528-rgnhfcbx	112	16	severe	severe	JJ
cord-252528-rgnhfcbx	112	17	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	112	18	could	could	MD
cord-252528-rgnhfcbx	112	19	result	result	VB
cord-252528-rgnhfcbx	112	20	from	from	IN
cord-252528-rgnhfcbx	112	21	the	the	DT
cord-252528-rgnhfcbx	112	22	SARS	SARS	NNP
cord-252528-rgnhfcbx	112	23	-	-	HYPH
cord-252528-rgnhfcbx	112	24	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	112	25	infection	infection	NN
cord-252528-rgnhfcbx	112	26	itself	-PRON-	PRP
cord-252528-rgnhfcbx	112	27	,	,	,
cord-252528-rgnhfcbx	112	28	the	the	DT
cord-252528-rgnhfcbx	112	29	bacterial	bacterial	JJ
cord-252528-rgnhfcbx	112	30	infection	infection	NN
cord-252528-rgnhfcbx	112	31	secondary	secondary	JJ
cord-252528-rgnhfcbx	112	32	to	to	IN
cord-252528-rgnhfcbx	112	33	the	the	DT
cord-252528-rgnhfcbx	112	34	SARS	SARS	NNP
cord-252528-rgnhfcbx	112	35	-	-	HYPH
cord-252528-rgnhfcbx	112	36	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	112	37	infection	infection	NN
cord-252528-rgnhfcbx	112	38	in	in	IN
cord-252528-rgnhfcbx	112	39	immune	immune	NN
cord-252528-rgnhfcbx	112	40	-	-	HYPH
cord-252528-rgnhfcbx	112	41	compromised	compromise	VBN
cord-252528-rgnhfcbx	112	42	individuals	individual	NNS
cord-252528-rgnhfcbx	112	43	,	,	,
cord-252528-rgnhfcbx	112	44	or	or	CC
cord-252528-rgnhfcbx	112	45	the	the	DT
cord-252528-rgnhfcbx	112	46	excessive	excessive	JJ
cord-252528-rgnhfcbx	112	47	innate	innate	JJ
cord-252528-rgnhfcbx	112	48	immune	immune	JJ
cord-252528-rgnhfcbx	112	49	response	response	NN
cord-252528-rgnhfcbx	112	50	to	to	IN
cord-252528-rgnhfcbx	112	51	damage	damage	NN
cord-252528-rgnhfcbx	112	52	-	-	HYPH
cord-252528-rgnhfcbx	112	53	associated	associate	VBN
cord-252528-rgnhfcbx	112	54	molecular	molecular	JJ
cord-252528-rgnhfcbx	112	55	patterns	pattern	NNS
cord-252528-rgnhfcbx	112	56	(	(	-LRB-
cord-252528-rgnhfcbx	112	57	DAMP	damp	VB
cord-252528-rgnhfcbx	112	58	)	)	-RRB-
cord-252528-rgnhfcbx	112	59	produced	produce	VBN
cord-252528-rgnhfcbx	112	60	by	by	IN
cord-252528-rgnhfcbx	112	61	tissue	tissue	NN
cord-252528-rgnhfcbx	112	62	damages	damage	NNS
cord-252528-rgnhfcbx	112	63	due	due	JJ
cord-252528-rgnhfcbx	112	64	to	to	IN
cord-252528-rgnhfcbx	112	65	SARS	SARS	NNP
cord-252528-rgnhfcbx	112	66	-	-	HYPH
cord-252528-rgnhfcbx	112	67	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	112	68	invasion	invasion	NN
cord-252528-rgnhfcbx	112	69	[	[	-LRB-
cord-252528-rgnhfcbx	112	70	2	2	CD
cord-252528-rgnhfcbx	112	71	,	,	,
cord-252528-rgnhfcbx	112	72	4	4	CD
cord-252528-rgnhfcbx	112	73	]	]	-RRB-
cord-252528-rgnhfcbx	112	74	.	.	.
cord-252528-rgnhfcbx	113	1	Hence	hence	RB
cord-252528-rgnhfcbx	113	2	,	,	,
cord-252528-rgnhfcbx	113	3	blocking	block	VBG
cord-252528-rgnhfcbx	113	4	the	the	DT
cord-252528-rgnhfcbx	113	5	host	host	NN
cord-252528-rgnhfcbx	113	6	cell	cell	NN
cord-252528-rgnhfcbx	113	7	entry	entry	NN
cord-252528-rgnhfcbx	113	8	and	and	CC
cord-252528-rgnhfcbx	113	9	the	the	DT
cord-252528-rgnhfcbx	113	10	replication	replication	NN
cord-252528-rgnhfcbx	113	11	of	of	IN
cord-252528-rgnhfcbx	113	12	SARS	SARS	NNP
cord-252528-rgnhfcbx	113	13	-	-	HYPH
cord-252528-rgnhfcbx	113	14	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	113	15	during	during	IN
cord-252528-rgnhfcbx	113	16	early	early	JJ
cord-252528-rgnhfcbx	113	17	infection	infection	NN
cord-252528-rgnhfcbx	113	18	could	could	MD
cord-252528-rgnhfcbx	113	19	prevent	prevent	VB
cord-252528-rgnhfcbx	113	20	the	the	DT
cord-252528-rgnhfcbx	113	21	excessive	excessive	JJ
cord-252528-rgnhfcbx	113	22	release	release	NN
cord-252528-rgnhfcbx	113	23	of	of	IN
cord-252528-rgnhfcbx	113	24	the	the	DT
cord-252528-rgnhfcbx	113	25	pro	pro	JJ
cord-252528-rgnhfcbx	113	26	-	-	JJ
cord-252528-rgnhfcbx	113	27	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	113	28	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	113	29	in	in	IN
cord-252528-rgnhfcbx	113	30	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	113	31	.	.	.
cord-252528-rgnhfcbx	114	1	However	however	RB
cord-252528-rgnhfcbx	114	2	,	,	,
cord-252528-rgnhfcbx	114	3	for	for	IN
cord-252528-rgnhfcbx	114	4	severe	severe	JJ
cord-252528-rgnhfcbx	114	5	patients	patient	NNS
cord-252528-rgnhfcbx	114	6	who	who	WP
cord-252528-rgnhfcbx	114	7	have	have	VBP
cord-252528-rgnhfcbx	114	8	already	already	RB
cord-252528-rgnhfcbx	114	9	developed	develop	VBN
cord-252528-rgnhfcbx	114	10	excessive	excessive	JJ
cord-252528-rgnhfcbx	114	11	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	114	12	response	response	NN
cord-252528-rgnhfcbx	114	13	,	,	,
cord-252528-rgnhfcbx	114	14	antagonizing	antagonize	VBG
cord-252528-rgnhfcbx	114	15	the	the	DT
cord-252528-rgnhfcbx	114	16	productions	production	NNS
cord-252528-rgnhfcbx	114	17	and	and	CC
cord-252528-rgnhfcbx	114	18	activities	activity	NNS
cord-252528-rgnhfcbx	114	19	of	of	IN
cord-252528-rgnhfcbx	114	20	the	the	DT
cord-252528-rgnhfcbx	114	21	pro	pro	JJ
cord-252528-rgnhfcbx	114	22	-	-	JJ
cord-252528-rgnhfcbx	114	23	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	114	24	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	114	25	could	could	MD
cord-252528-rgnhfcbx	114	26	be	be	VB
cord-252528-rgnhfcbx	114	27	a	a	DT
cord-252528-rgnhfcbx	114	28	better	well	JJR
cord-252528-rgnhfcbx	114	29	approach	approach	NN
cord-252528-rgnhfcbx	114	30	to	to	TO
cord-252528-rgnhfcbx	114	31	attenuate	attenuate	VB
cord-252528-rgnhfcbx	114	32	the	the	DT
cord-252528-rgnhfcbx	114	33	over	over	RB
cord-252528-rgnhfcbx	114	34	-	-	HYPH
cord-252528-rgnhfcbx	114	35	activated	activate	VBN
cord-252528-rgnhfcbx	114	36	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	114	37	response	response	NN
cord-252528-rgnhfcbx	114	38	and	and	CC
cord-252528-rgnhfcbx	114	39	to	to	TO
cord-252528-rgnhfcbx	114	40	reduce	reduce	VB
cord-252528-rgnhfcbx	114	41	the	the	DT
cord-252528-rgnhfcbx	114	42	risk	risk	NN
cord-252528-rgnhfcbx	114	43	of	of	IN
cord-252528-rgnhfcbx	114	44	vascular	vascular	JJ
cord-252528-rgnhfcbx	114	45	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	114	46	.	.	.
cord-252528-rgnhfcbx	115	1	Cytokines	cytokine	NNS
cord-252528-rgnhfcbx	115	2	with	with	IN
cord-252528-rgnhfcbx	115	3	pro	pro	JJ
cord-252528-rgnhfcbx	115	4	-	-	JJ
cord-252528-rgnhfcbx	115	5	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	115	6	activities	activity	NNS
cord-252528-rgnhfcbx	115	7	IL-2	il-2	NN
cord-252528-rgnhfcbx	116	1	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	116	2	is	be	VBZ
cord-252528-rgnhfcbx	116	3	pleiotropic	pleiotropic	JJ
cord-252528-rgnhfcbx	116	4	regarding	regard	VBG
cord-252528-rgnhfcbx	116	5	its	-PRON-	PRP$
cord-252528-rgnhfcbx	116	6	influence	influence	NN
cord-252528-rgnhfcbx	116	7	on	on	IN
cord-252528-rgnhfcbx	116	8	the	the	DT
cord-252528-rgnhfcbx	116	9	differentiation	differentiation	NN
cord-252528-rgnhfcbx	116	10	of	of	IN
cord-252528-rgnhfcbx	116	11	various	various	JJ
cord-252528-rgnhfcbx	116	12	CD4	CD4	NNP
cord-252528-rgnhfcbx	116	13	+	+	CC
cord-252528-rgnhfcbx	116	14	T	t	NN
cord-252528-rgnhfcbx	116	15	cell	cell	NN
cord-252528-rgnhfcbx	116	16	subsets	subset	NNS
cord-252528-rgnhfcbx	116	17	.	.	.
cord-252528-rgnhfcbx	117	1	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	117	2	induces	induce	VBZ
cord-252528-rgnhfcbx	117	3	Th1	th1	NN
cord-252528-rgnhfcbx	117	4	and	and	CC
cord-252528-rgnhfcbx	117	5	Th2	th2	CD
cord-252528-rgnhfcbx	117	6	differentiation	differentiation	NN
cord-252528-rgnhfcbx	117	7	by	by	IN
cord-252528-rgnhfcbx	117	8	enhancing	enhance	VBG
cord-252528-rgnhfcbx	117	9	interleukin-12	interleukin-12	XX
cord-252528-rgnhfcbx	117	10	(	(	-LRB-
cord-252528-rgnhfcbx	117	11	IL-12	IL-12	NNP
cord-252528-rgnhfcbx	117	12	)	)	-RRB-
cord-252528-rgnhfcbx	117	13	receptor	receptor	NN
cord-252528-rgnhfcbx	117	14	expression	expression	NN
cord-252528-rgnhfcbx	117	15	and	and	CC
cord-252528-rgnhfcbx	117	16	IL-4	IL-4	NNP
cord-252528-rgnhfcbx	117	17	receptor	receptor	NN
cord-252528-rgnhfcbx	117	18	expression	expression	NN
cord-252528-rgnhfcbx	117	19	,	,	,
cord-252528-rgnhfcbx	117	20	respectively	respectively	RB
cord-252528-rgnhfcbx	117	21	,	,	,
cord-252528-rgnhfcbx	117	22	through	through	IN
cord-252528-rgnhfcbx	117	23	STAT5	stat5	NN
cord-252528-rgnhfcbx	117	24	[	[	-LRB-
cord-252528-rgnhfcbx	117	25	32	32	CD
cord-252528-rgnhfcbx	117	26	,	,	,
cord-252528-rgnhfcbx	117	27	33	33	CD
cord-252528-rgnhfcbx	117	28	]	]	-RRB-
cord-252528-rgnhfcbx	117	29	.	.	.
cord-252528-rgnhfcbx	118	1	However	however	RB
cord-252528-rgnhfcbx	118	2	,	,	,
cord-252528-rgnhfcbx	118	3	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	118	4	plays	play	VBZ
cord-252528-rgnhfcbx	118	5	an	an	DT
cord-252528-rgnhfcbx	118	6	inhibitory	inhibitory	JJ
cord-252528-rgnhfcbx	118	7	role	role	NN
cord-252528-rgnhfcbx	118	8	in	in	IN
cord-252528-rgnhfcbx	118	9	the	the	DT
cord-252528-rgnhfcbx	118	10	differentiation	differentiation	NN
cord-252528-rgnhfcbx	118	11	of	of	IN
cord-252528-rgnhfcbx	118	12	Th17	Th17	NNP
cord-252528-rgnhfcbx	118	13	[	[	-LRB-
cord-252528-rgnhfcbx	118	14	32	32	CD
cord-252528-rgnhfcbx	118	15	]	]	-RRB-
cord-252528-rgnhfcbx	118	16	.	.	.
cord-252528-rgnhfcbx	119	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	119	2	,	,	,
cord-252528-rgnhfcbx	119	3	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	119	4	has	have	VBZ
cord-252528-rgnhfcbx	119	5	been	be	VBN
cord-252528-rgnhfcbx	119	6	shown	show	VBN
cord-252528-rgnhfcbx	119	7	to	to	TO
cord-252528-rgnhfcbx	119	8	increase	increase	VB
cord-252528-rgnhfcbx	119	9	the	the	DT
cord-252528-rgnhfcbx	119	10	thymic	thymic	JJ
cord-252528-rgnhfcbx	119	11	or	or	CC
cord-252528-rgnhfcbx	119	12	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	119	13	production	production	NN
cord-252528-rgnhfcbx	119	14	of	of	IN
cord-252528-rgnhfcbx	119	15	Tregs	Tregs	NNP
cord-252528-rgnhfcbx	119	16	and	and	CC
cord-252528-rgnhfcbx	119	17	the	the	DT
cord-252528-rgnhfcbx	119	18	immuno	immuno	JJ
cord-252528-rgnhfcbx	119	19	-	-	HYPH
cord-252528-rgnhfcbx	119	20	suppressive	suppressive	JJ
cord-252528-rgnhfcbx	119	21	activity	activity	NN
cord-252528-rgnhfcbx	119	22	of	of	IN
cord-252528-rgnhfcbx	119	23	Tregs	Tregs	NNP
cord-252528-rgnhfcbx	119	24	[	[	-LRB-
cord-252528-rgnhfcbx	119	25	34	34	CD
cord-252528-rgnhfcbx	119	26	,	,	,
cord-252528-rgnhfcbx	119	27	35	35	CD
cord-252528-rgnhfcbx	119	28	]	]	-RRB-
cord-252528-rgnhfcbx	119	29	.	.	.
cord-252528-rgnhfcbx	120	1	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	120	2	can	can	MD
cord-252528-rgnhfcbx	120	3	stimulate	stimulate	VB
cord-252528-rgnhfcbx	120	4	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	120	5	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	120	6	activator	activator	NN
cord-252528-rgnhfcbx	120	7	inhibitor	inhibitor	NN
cord-252528-rgnhfcbx	120	8	(	(	-LRB-
cord-252528-rgnhfcbx	120	9	PAI-1	PAI-1	NNP
cord-252528-rgnhfcbx	120	10	)	)	-RRB-
cord-252528-rgnhfcbx	120	11	release	release	NN
cord-252528-rgnhfcbx	120	12	in	in	IN
cord-252528-rgnhfcbx	120	13	vitro	vitro	FW
cord-252528-rgnhfcbx	120	14	,	,	,
cord-252528-rgnhfcbx	120	15	indicating	indicate	VBG
cord-252528-rgnhfcbx	120	16	a	a	DT
cord-252528-rgnhfcbx	120	17	potential	potential	NN
cord-252528-rgnhfcbx	120	18	for	for	IN
cord-252528-rgnhfcbx	120	19	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	120	20	to	to	TO
cord-252528-rgnhfcbx	120	21	inhibit	inhibit	VB
cord-252528-rgnhfcbx	120	22	fibrinolysis	fibrinolysis	NN
cord-252528-rgnhfcbx	120	23	[	[	-LRB-
cord-252528-rgnhfcbx	120	24	36	36	CD
cord-252528-rgnhfcbx	120	25	]	]	-RRB-
cord-252528-rgnhfcbx	120	26	.	.	.
cord-252528-rgnhfcbx	121	1	Results	result	NNS
cord-252528-rgnhfcbx	121	2	of	of	IN
cord-252528-rgnhfcbx	121	3	clinical	clinical	JJ
cord-252528-rgnhfcbx	121	4	study	study	NN
cord-252528-rgnhfcbx	121	5	have	have	VBP
cord-252528-rgnhfcbx	121	6	shown	show	VBN
cord-252528-rgnhfcbx	121	7	that	that	IN
cord-252528-rgnhfcbx	121	8	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	121	9	can	can	MD
cord-252528-rgnhfcbx	121	10	activate	activate	VB
cord-252528-rgnhfcbx	121	11	both	both	DT
cord-252528-rgnhfcbx	121	12	coagulation	coagulation	NN
cord-252528-rgnhfcbx	121	13	and	and	CC
cord-252528-rgnhfcbx	121	14	fibrinolysis	fibrinolysis	NN
cord-252528-rgnhfcbx	121	15	in	in	IN
cord-252528-rgnhfcbx	121	16	vivo	vivo	NN
cord-252528-rgnhfcbx	121	17	,	,	,
cord-252528-rgnhfcbx	121	18	possibly	possibly	RB
cord-252528-rgnhfcbx	121	19	mediated	mediate	VBN
cord-252528-rgnhfcbx	121	20	by	by	IN
cord-252528-rgnhfcbx	121	21	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	121	22	induced	induce	VBD
cord-252528-rgnhfcbx	121	23	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	121	24	that	that	WDT
cord-252528-rgnhfcbx	121	25	can	can	MD
cord-252528-rgnhfcbx	121	26	impair	impair	VB
cord-252528-rgnhfcbx	121	27	the	the	DT
cord-252528-rgnhfcbx	121	28	anti	anti	JJ
cord-252528-rgnhfcbx	121	29	-	-	JJ
cord-252528-rgnhfcbx	121	30	coagulant	coagulant	JJ
cord-252528-rgnhfcbx	121	31	function	function	NN
cord-252528-rgnhfcbx	121	32	of	of	IN
cord-252528-rgnhfcbx	121	33	the	the	DT
cord-252528-rgnhfcbx	121	34	vascular	vascular	JJ
cord-252528-rgnhfcbx	121	35	endothelium	endothelium	NN
cord-252528-rgnhfcbx	121	36	[	[	-LRB-
cord-252528-rgnhfcbx	121	37	37	37	CD
cord-252528-rgnhfcbx	121	38	]	]	-RRB-
cord-252528-rgnhfcbx	121	39	.	.	.
cord-252528-rgnhfcbx	122	1	By	by	IN
cord-252528-rgnhfcbx	122	2	initiating	initiate	VBG
cord-252528-rgnhfcbx	122	3	the	the	DT
cord-252528-rgnhfcbx	122	4	differentiation	differentiation	NN
cord-252528-rgnhfcbx	122	5	of	of	IN
cord-252528-rgnhfcbx	122	6	Th1	th1	NN
cord-252528-rgnhfcbx	122	7	,	,	,
cord-252528-rgnhfcbx	122	8	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	122	9	can	can	MD
cord-252528-rgnhfcbx	122	10	induce	induce	VB
cord-252528-rgnhfcbx	122	11	the	the	DT
cord-252528-rgnhfcbx	122	12	production	production	NN
cord-252528-rgnhfcbx	122	13	of	of	IN
cord-252528-rgnhfcbx	122	14	IFN	IFN	NNP
cord-252528-rgnhfcbx	122	15	-	-	HYPH
cord-252528-rgnhfcbx	122	16	γ	γ	NNP
cord-252528-rgnhfcbx	122	17	in	in	IN
cord-252528-rgnhfcbx	122	18	T	T	NNP
cord-252528-rgnhfcbx	122	19	cell	cell	NN
cord-252528-rgnhfcbx	122	20	subsets	subset	NNS
cord-252528-rgnhfcbx	122	21	[	[	-LRB-
cord-252528-rgnhfcbx	122	22	32	32	CD
cord-252528-rgnhfcbx	122	23	,	,	,
cord-252528-rgnhfcbx	122	24	38	38	CD
cord-252528-rgnhfcbx	122	25	]	]	-RRB-
cord-252528-rgnhfcbx	122	26	.	.	.
cord-252528-rgnhfcbx	123	1	IFN	IFN	NNP
cord-252528-rgnhfcbx	123	2	-	-	HYPH
cord-252528-rgnhfcbx	123	3	γ	γ	NNP
cord-252528-rgnhfcbx	123	4	is	be	VBZ
cord-252528-rgnhfcbx	123	5	associated	associate	VBN
cord-252528-rgnhfcbx	123	6	with	with	IN
cord-252528-rgnhfcbx	123	7	pro	pro	JJ
cord-252528-rgnhfcbx	123	8	-	-	JJ
cord-252528-rgnhfcbx	123	9	coagulant	coagulant	JJ
cord-252528-rgnhfcbx	123	10	effects	effect	NNS
cord-252528-rgnhfcbx	123	11	by	by	IN
cord-252528-rgnhfcbx	123	12	several	several	JJ
cord-252528-rgnhfcbx	123	13	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	123	14	introduced	introduce	VBN
cord-252528-rgnhfcbx	123	15	below	below	RB
cord-252528-rgnhfcbx	123	16	.	.	.
cord-252528-rgnhfcbx	124	1	IFN	IFN	NNP
cord-252528-rgnhfcbx	124	2	-	-	HYPH
cord-252528-rgnhfcbx	124	3	γ	γ	NN
cord-252528-rgnhfcbx	124	4	IFN	IFN	NNP
cord-252528-rgnhfcbx	124	5	-	-	HYPH
cord-252528-rgnhfcbx	124	6	γ	γ	NNP
cord-252528-rgnhfcbx	124	7	plays	play	VBZ
cord-252528-rgnhfcbx	124	8	a	a	DT
cord-252528-rgnhfcbx	124	9	dual	dual	JJ
cord-252528-rgnhfcbx	124	10	role	role	NN
cord-252528-rgnhfcbx	124	11	in	in	IN
cord-252528-rgnhfcbx	124	12	vascular	vascular	JJ
cord-252528-rgnhfcbx	124	13	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	124	14	by	by	IN
cord-252528-rgnhfcbx	124	15	promoting	promote	VBG
cord-252528-rgnhfcbx	124	16	thrombus	thrombus	NN
cord-252528-rgnhfcbx	124	17	formation	formation	NN
cord-252528-rgnhfcbx	124	18	,	,	,
cord-252528-rgnhfcbx	124	19	while	while	IN
cord-252528-rgnhfcbx	124	20	delaying	delay	VBG
cord-252528-rgnhfcbx	124	21	thrombus	thrombus	NN
cord-252528-rgnhfcbx	124	22	resolution	resolution	NN
cord-252528-rgnhfcbx	124	23	.	.	.
cord-252528-rgnhfcbx	125	1	According	accord	VBG
cord-252528-rgnhfcbx	125	2	to	to	IN
cord-252528-rgnhfcbx	125	3	previous	previous	JJ
cord-252528-rgnhfcbx	125	4	experimental	experimental	JJ
cord-252528-rgnhfcbx	125	5	evidence	evidence	NN
cord-252528-rgnhfcbx	125	6	,	,	,
cord-252528-rgnhfcbx	125	7	IFN	IFN	NNP
cord-252528-rgnhfcbx	125	8	-	-	HYPH
cord-252528-rgnhfcbx	125	9	γ	γ	NNP
cord-252528-rgnhfcbx	125	10	promotes	promote	VBZ
cord-252528-rgnhfcbx	125	11	thrombus	thrombus	NN
cord-252528-rgnhfcbx	125	12	formation	formation	NN
cord-252528-rgnhfcbx	125	13	mainly	mainly	RB
cord-252528-rgnhfcbx	125	14	through	through	IN
cord-252528-rgnhfcbx	125	15	increasing	increase	VBG
cord-252528-rgnhfcbx	125	16	the	the	DT
cord-252528-rgnhfcbx	125	17	platelet	platelet	NN
cord-252528-rgnhfcbx	125	18	activities	activity	NNS
cord-252528-rgnhfcbx	125	19	and	and	CC
cord-252528-rgnhfcbx	125	20	impairing	impair	VBG
cord-252528-rgnhfcbx	125	21	the	the	DT
cord-252528-rgnhfcbx	125	22	vascular	vascular	JJ
cord-252528-rgnhfcbx	125	23	endothelium	endothelium	NN
cord-252528-rgnhfcbx	125	24	.	.	.
cord-252528-rgnhfcbx	126	1	In	in	IN
cord-252528-rgnhfcbx	126	2	vitro	vitro	FW
cord-252528-rgnhfcbx	126	3	experiment	experiment	NN
cord-252528-rgnhfcbx	126	4	on	on	IN
cord-252528-rgnhfcbx	126	5	monocytic	monocytic	JJ
cord-252528-rgnhfcbx	126	6	U937	U937	NNP
cord-252528-rgnhfcbx	126	7	cell	cell	NN
cord-252528-rgnhfcbx	126	8	in	in	IN
cord-252528-rgnhfcbx	126	9	the	the	DT
cord-252528-rgnhfcbx	126	10	condition	condition	NN
cord-252528-rgnhfcbx	126	11	of	of	IN
cord-252528-rgnhfcbx	126	12	a	a	DT
cord-252528-rgnhfcbx	126	13	low	low	JJ
cord-252528-rgnhfcbx	126	14	thrombin	thrombin	JJ
cord-252528-rgnhfcbx	126	15	concentration	concentration	NN
cord-252528-rgnhfcbx	126	16	has	have	VBZ
cord-252528-rgnhfcbx	126	17	shown	show	VBN
cord-252528-rgnhfcbx	126	18	that	that	IN
cord-252528-rgnhfcbx	126	19	IFN	IFN	NNP
cord-252528-rgnhfcbx	126	20	-	-	HYPH
cord-252528-rgnhfcbx	126	21	γ	γ	NNP
cord-252528-rgnhfcbx	126	22	increases	increase	VBZ
cord-252528-rgnhfcbx	126	23	platelet	platelet	NN
cord-252528-rgnhfcbx	126	24	adhesion	adhesion	NN
cord-252528-rgnhfcbx	126	25	to	to	IN
cord-252528-rgnhfcbx	126	26	the	the	DT
cord-252528-rgnhfcbx	126	27	monocytic	monocytic	JJ
cord-252528-rgnhfcbx	126	28	cell	cell	NN
cord-252528-rgnhfcbx	126	29	,	,	,
cord-252528-rgnhfcbx	126	30	thereby	thereby	RB
cord-252528-rgnhfcbx	126	31	promoting	promote	VBG
cord-252528-rgnhfcbx	126	32	platelet	platelet	NN
cord-252528-rgnhfcbx	126	33	activation	activation	NN
cord-252528-rgnhfcbx	126	34	,	,	,
cord-252528-rgnhfcbx	126	35	which	which	WDT
cord-252528-rgnhfcbx	126	36	is	be	VBZ
cord-252528-rgnhfcbx	126	37	indicated	indicate	VBN
cord-252528-rgnhfcbx	126	38	by	by	IN
cord-252528-rgnhfcbx	126	39	enhanced	enhanced	JJ
cord-252528-rgnhfcbx	126	40	platelet	platelet	NN
cord-252528-rgnhfcbx	126	41	5-hydroxytryptamine	5-hydroxytryptamine	CD
cord-252528-rgnhfcbx	126	42	(	(	-LRB-
cord-252528-rgnhfcbx	126	43	5-HT	5-ht	CD
cord-252528-rgnhfcbx	126	44	)	)	-RRB-
cord-252528-rgnhfcbx	126	45	release	release	VBP
cord-252528-rgnhfcbx	126	46	[	[	-LRB-
cord-252528-rgnhfcbx	126	47	39	39	CD
cord-252528-rgnhfcbx	126	48	]	]	-RRB-
cord-252528-rgnhfcbx	126	49	.	.	.
cord-252528-rgnhfcbx	127	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	127	2	,	,	,
cord-252528-rgnhfcbx	127	3	in	in	IN
cord-252528-rgnhfcbx	127	4	vitro	vitro	FW
cord-252528-rgnhfcbx	127	5	evidence	evidence	NN
cord-252528-rgnhfcbx	127	6	has	have	VBZ
cord-252528-rgnhfcbx	127	7	also	also	RB
cord-252528-rgnhfcbx	127	8	indicated	indicate	VBN
cord-252528-rgnhfcbx	127	9	that	that	IN
cord-252528-rgnhfcbx	127	10	Th1related	th1relate	VBN
cord-252528-rgnhfcbx	127	11	activities	activity	NNS
cord-252528-rgnhfcbx	127	12	,	,	,
cord-252528-rgnhfcbx	127	13	especially	especially	RB
cord-252528-rgnhfcbx	127	14	IFN	IFN	NNP
cord-252528-rgnhfcbx	127	15	-	-	HYPH
cord-252528-rgnhfcbx	127	16	γ	γ	NN
cord-252528-rgnhfcbx	127	17	secretion	secretion	NN
cord-252528-rgnhfcbx	127	18	,	,	,
cord-252528-rgnhfcbx	127	19	increase	increase	VB
cord-252528-rgnhfcbx	127	20	the	the	DT
cord-252528-rgnhfcbx	127	21	expression	expression	NN
cord-252528-rgnhfcbx	127	22	of	of	IN
cord-252528-rgnhfcbx	127	23	tissue	tissue	NN
cord-252528-rgnhfcbx	127	24	factor	factor	NN
cord-252528-rgnhfcbx	127	25	(	(	-LRB-
cord-252528-rgnhfcbx	127	26	TF	TF	NNP
cord-252528-rgnhfcbx	127	27	)	)	-RRB-
cord-252528-rgnhfcbx	127	28	in	in	IN
cord-252528-rgnhfcbx	127	29	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	127	30	,	,	,
cord-252528-rgnhfcbx	127	31	facilitating	facilitate	VBG
cord-252528-rgnhfcbx	127	32	the	the	DT
cord-252528-rgnhfcbx	127	33	pro	pro	JJ
cord-252528-rgnhfcbx	127	34	-	-	JJ
cord-252528-rgnhfcbx	127	35	coagulant	coagulant	JJ
cord-252528-rgnhfcbx	127	36	activity	activity	NN
cord-252528-rgnhfcbx	127	37	of	of	IN
cord-252528-rgnhfcbx	127	38	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	127	39	[	[	-LRB-
cord-252528-rgnhfcbx	127	40	40	40	CD
cord-252528-rgnhfcbx	127	41	]	]	-RRB-
cord-252528-rgnhfcbx	127	42	.	.	.
cord-252528-rgnhfcbx	128	1	IFN	IFN	NNP
cord-252528-rgnhfcbx	128	2	-	-	HYPH
cord-252528-rgnhfcbx	128	3	γ	γ	NNP
cord-252528-rgnhfcbx	128	4	plays	play	VBZ
cord-252528-rgnhfcbx	128	5	a	a	DT
cord-252528-rgnhfcbx	128	6	crucial	crucial	JJ
cord-252528-rgnhfcbx	128	7	role	role	NN
cord-252528-rgnhfcbx	128	8	in	in	IN
cord-252528-rgnhfcbx	128	9	inflammation	inflammation	NN
cord-252528-rgnhfcbx	128	10	by	by	IN
cord-252528-rgnhfcbx	128	11	mediating	mediate	VBG
cord-252528-rgnhfcbx	128	12	macrophage	macrophage	NN
cord-252528-rgnhfcbx	128	13	activation	activation	NN
cord-252528-rgnhfcbx	128	14	and	and	CC
cord-252528-rgnhfcbx	128	15	leukocyte	leukocyte	NN
cord-252528-rgnhfcbx	128	16	recruitment	recruitment	NN
cord-252528-rgnhfcbx	128	17	.	.	.
cord-252528-rgnhfcbx	129	1	Results	result	NNS
cord-252528-rgnhfcbx	129	2	of	of	IN
cord-252528-rgnhfcbx	129	3	animal	animal	NN
cord-252528-rgnhfcbx	129	4	studies	study	NNS
cord-252528-rgnhfcbx	129	5	suggest	suggest	VBP
cord-252528-rgnhfcbx	129	6	that	that	IN
cord-252528-rgnhfcbx	129	7	increased	increase	VBN
cord-252528-rgnhfcbx	129	8	IFN	IFN	NNP
cord-252528-rgnhfcbx	129	9	-	-	HYPH
cord-252528-rgnhfcbx	129	10	γ	γ	NNP
cord-252528-rgnhfcbx	129	11	production	production	NN
cord-252528-rgnhfcbx	129	12	mediates	mediate	VBZ
cord-252528-rgnhfcbx	129	13	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	129	14	activation	activation	NN
cord-252528-rgnhfcbx	129	15	and	and	CC
cord-252528-rgnhfcbx	129	16	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	129	17	recruitment	recruitment	NNP
cord-252528-rgnhfcbx	129	18	to	to	IN
cord-252528-rgnhfcbx	129	19	the	the	DT
cord-252528-rgnhfcbx	129	20	vessel	vessel	NN
cord-252528-rgnhfcbx	129	21	,	,	,
cord-252528-rgnhfcbx	129	22	promoting	promote	VBG
cord-252528-rgnhfcbx	129	23	vascular	vascular	JJ
cord-252528-rgnhfcbx	129	24	inflammation	inflammation	NN
cord-252528-rgnhfcbx	129	25	,	,	,
cord-252528-rgnhfcbx	129	26	ROS	ROS	NNP
cord-252528-rgnhfcbx	129	27	production	production	NN
cord-252528-rgnhfcbx	129	28	,	,	,
cord-252528-rgnhfcbx	129	29	together	together	RB
cord-252528-rgnhfcbx	129	30	with	with	IN
cord-252528-rgnhfcbx	129	31	vascular	vascular	JJ
cord-252528-rgnhfcbx	129	32	EC	EC	NNP
cord-252528-rgnhfcbx	129	33	and	and	CC
cord-252528-rgnhfcbx	129	34	vascular	vascular	JJ
cord-252528-rgnhfcbx	129	35	smooth	smooth	JJ
cord-252528-rgnhfcbx	129	36	muscle	muscle	NN
cord-252528-rgnhfcbx	129	37	cell	cell	NN
cord-252528-rgnhfcbx	129	38	(	(	-LRB-
cord-252528-rgnhfcbx	129	39	SMC	SMC	NNP
cord-252528-rgnhfcbx	129	40	)	)	-RRB-
cord-252528-rgnhfcbx	129	41	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	129	42	[	[	-LRB-
cord-252528-rgnhfcbx	129	43	41	41	CD
cord-252528-rgnhfcbx	129	44	]	]	-RRB-
cord-252528-rgnhfcbx	129	45	.	.	.
cord-252528-rgnhfcbx	130	1	In	in	IN
cord-252528-rgnhfcbx	130	2	physiologic	physiologic	JJ
cord-252528-rgnhfcbx	130	3	conditions	condition	NNS
cord-252528-rgnhfcbx	130	4	,	,	,
cord-252528-rgnhfcbx	130	5	vascular	vascular	JJ
cord-252528-rgnhfcbx	130	6	ECs	ec	NNS
cord-252528-rgnhfcbx	130	7	maintain	maintain	VBP
cord-252528-rgnhfcbx	130	8	their	-PRON-	PRP$
cord-252528-rgnhfcbx	130	9	anti	anti	JJ
cord-252528-rgnhfcbx	130	10	-	-	JJ
cord-252528-rgnhfcbx	130	11	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	130	12	,	,	,
cord-252528-rgnhfcbx	130	13	anti	anti	JJ
cord-252528-rgnhfcbx	130	14	-	-	JJ
cord-252528-rgnhfcbx	130	15	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	130	16	,	,	,
cord-252528-rgnhfcbx	130	17	and	and	CC
cord-252528-rgnhfcbx	130	18	vasodilative	vasodilative	JJ
cord-252528-rgnhfcbx	130	19	properties	property	NNS
cord-252528-rgnhfcbx	130	20	by	by	IN
cord-252528-rgnhfcbx	130	21	producing	produce	VBG
cord-252528-rgnhfcbx	130	22	substances	substance	NNS
cord-252528-rgnhfcbx	130	23	,	,	,
cord-252528-rgnhfcbx	130	24	including	include	VBG
cord-252528-rgnhfcbx	130	25	anti	anti	NN
cord-252528-rgnhfcbx	130	26	-	-	JJ
cord-252528-rgnhfcbx	130	27	thrombin	thrombin	JJ
cord-252528-rgnhfcbx	130	28	,	,	,
cord-252528-rgnhfcbx	130	29	thrombomodulin	thrombomodulin	NNP
cord-252528-rgnhfcbx	130	30	,	,	,
cord-252528-rgnhfcbx	130	31	prostaglandins	prostaglandin	NNS
cord-252528-rgnhfcbx	130	32	,	,	,
cord-252528-rgnhfcbx	130	33	and	and	CC
cord-252528-rgnhfcbx	130	34	nitric	nitric	NN
cord-252528-rgnhfcbx	130	35	oxide	oxide	NN
cord-252528-rgnhfcbx	130	36	(	(	-LRB-
cord-252528-rgnhfcbx	130	37	NO	no	RB
cord-252528-rgnhfcbx	130	38	)	)	-RRB-
cord-252528-rgnhfcbx	130	39	[	[	-LRB-
cord-252528-rgnhfcbx	130	40	42	42	CD
cord-252528-rgnhfcbx	130	41	]	]	-RRB-
cord-252528-rgnhfcbx	130	42	.	.	.
cord-252528-rgnhfcbx	131	1	IFN	IFN	NNP
cord-252528-rgnhfcbx	131	2	-	-	HYPH
cord-252528-rgnhfcbx	131	3	γ	γ	NNP
cord-252528-rgnhfcbx	131	4	induces	induce	VBZ
cord-252528-rgnhfcbx	131	5	vascular	vascular	JJ
cord-252528-rgnhfcbx	131	6	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	131	7	by	by	IN
cord-252528-rgnhfcbx	131	8	promoting	promote	VBG
cord-252528-rgnhfcbx	131	9	the	the	DT
cord-252528-rgnhfcbx	131	10	expression	expression	NN
cord-252528-rgnhfcbx	131	11	of	of	IN
cord-252528-rgnhfcbx	131	12	chemoattractant	chemoattractant	NN
cord-252528-rgnhfcbx	131	13	molecule	molecule	NN
cord-252528-rgnhfcbx	131	14	MCP-1	MCP-1	NNP
cord-252528-rgnhfcbx	131	15	,	,	,
cord-252528-rgnhfcbx	131	16	changing	change	VBG
cord-252528-rgnhfcbx	131	17	the	the	DT
cord-252528-rgnhfcbx	131	18	physiologic	physiologic	JJ
cord-252528-rgnhfcbx	131	19	anti	anti	JJ
cord-252528-rgnhfcbx	131	20	-	-	JJ
cord-252528-rgnhfcbx	131	21	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	131	22	phenotype	phenotype	NN
cord-252528-rgnhfcbx	131	23	of	of	IN
cord-252528-rgnhfcbx	131	24	the	the	DT
cord-252528-rgnhfcbx	131	25	vascular	vascular	JJ
cord-252528-rgnhfcbx	131	26	ECs	ec	NNS
cord-252528-rgnhfcbx	131	27	into	into	IN
cord-252528-rgnhfcbx	131	28	the	the	DT
cord-252528-rgnhfcbx	131	29	pathological	pathological	JJ
cord-252528-rgnhfcbx	131	30	pro	pro	JJ
cord-252528-rgnhfcbx	131	31	-	-	JJ
cord-252528-rgnhfcbx	131	32	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	131	33	phenotype	phenotype	NN
cord-252528-rgnhfcbx	131	34	,	,	,
cord-252528-rgnhfcbx	131	35	thereby	thereby	RB
cord-252528-rgnhfcbx	131	36	leading	lead	VBG
cord-252528-rgnhfcbx	131	37	to	to	IN
cord-252528-rgnhfcbx	131	38	enhanced	enhance	VBN
cord-252528-rgnhfcbx	131	39	ROS	ROS	NNP
cord-252528-rgnhfcbx	131	40	production	production	NN
cord-252528-rgnhfcbx	131	41	and	and	CC
cord-252528-rgnhfcbx	131	42	decreased	decrease	VBD
cord-252528-rgnhfcbx	131	43	vasodilative	vasodilative	JJ
cord-252528-rgnhfcbx	131	44	function	function	NN
cord-252528-rgnhfcbx	131	45	of	of	IN
cord-252528-rgnhfcbx	131	46	the	the	DT
cord-252528-rgnhfcbx	131	47	vascular	vascular	JJ
cord-252528-rgnhfcbx	131	48	endothelium	endothelium	NN
cord-252528-rgnhfcbx	131	49	,	,	,
cord-252528-rgnhfcbx	131	50	in	in	IN
cord-252528-rgnhfcbx	131	51	favor	favor	NN
cord-252528-rgnhfcbx	131	52	of	of	IN
cord-252528-rgnhfcbx	131	53	thrombus	thrombus	NN
cord-252528-rgnhfcbx	131	54	formation	formation	NN
cord-252528-rgnhfcbx	131	55	[	[	-LRB-
cord-252528-rgnhfcbx	131	56	43	43	CD
cord-252528-rgnhfcbx	131	57	]	]	-RRB-
cord-252528-rgnhfcbx	131	58	.	.	.
cord-252528-rgnhfcbx	132	1	Damage	damage	NN
cord-252528-rgnhfcbx	132	2	of	of	IN
cord-252528-rgnhfcbx	132	3	vascular	vascular	JJ
cord-252528-rgnhfcbx	132	4	ECs	ec	NNS
cord-252528-rgnhfcbx	132	5	exposes	expose	VBZ
cord-252528-rgnhfcbx	132	6	the	the	DT
cord-252528-rgnhfcbx	132	7	sub	sub	JJ
cord-252528-rgnhfcbx	132	8	-	-	JJ
cord-252528-rgnhfcbx	132	9	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	132	10	pro	pro	JJ
cord-252528-rgnhfcbx	132	11	-	-	JJ
cord-252528-rgnhfcbx	132	12	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	132	13	matrix	matrix	NN
cord-252528-rgnhfcbx	132	14	to	to	IN
cord-252528-rgnhfcbx	132	15	the	the	DT
cord-252528-rgnhfcbx	132	16	circulating	circulate	VBG
cord-252528-rgnhfcbx	132	17	platelets	platelet	NNS
cord-252528-rgnhfcbx	132	18	.	.	.
cord-252528-rgnhfcbx	133	1	Interactions	interaction	NNS
cord-252528-rgnhfcbx	133	2	between	between	IN
cord-252528-rgnhfcbx	133	3	subendothelial	subendothelial	JJ
cord-252528-rgnhfcbx	133	4	pro	pro	JJ
cord-252528-rgnhfcbx	133	5	-	-	JJ
cord-252528-rgnhfcbx	133	6	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	133	7	proteins	protein	NNS
cord-252528-rgnhfcbx	133	8	and	and	CC
cord-252528-rgnhfcbx	133	9	platelets	platelet	NNS
cord-252528-rgnhfcbx	133	10	result	result	VBP
cord-252528-rgnhfcbx	133	11	in	in	IN
cord-252528-rgnhfcbx	133	12	platelet	platelet	NN
cord-252528-rgnhfcbx	133	13	adhesion	adhesion	NN
cord-252528-rgnhfcbx	133	14	,	,	,
cord-252528-rgnhfcbx	133	15	activation	activation	NN
cord-252528-rgnhfcbx	133	16	,	,	,
cord-252528-rgnhfcbx	133	17	and	and	CC
cord-252528-rgnhfcbx	133	18	aggregation	aggregation	NN
cord-252528-rgnhfcbx	133	19	through	through	IN
cord-252528-rgnhfcbx	133	20	complex	complex	JJ
cord-252528-rgnhfcbx	133	21	receptor	receptor	NN
cord-252528-rgnhfcbx	133	22	-	-	HYPH
cord-252528-rgnhfcbx	133	23	mediated	mediate	VBN
cord-252528-rgnhfcbx	133	24	signalings	signaling	NNS
cord-252528-rgnhfcbx	133	25	[	[	-LRB-
cord-252528-rgnhfcbx	133	26	44	44	CD
cord-252528-rgnhfcbx	133	27	,	,	,
cord-252528-rgnhfcbx	133	28	45	45	CD
cord-252528-rgnhfcbx	133	29	]	]	-RRB-
cord-252528-rgnhfcbx	133	30	.	.	.
cord-252528-rgnhfcbx	134	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	134	2	,	,	,
cord-252528-rgnhfcbx	134	3	a	a	DT
cord-252528-rgnhfcbx	134	4	recent	recent	JJ
cord-252528-rgnhfcbx	134	5	animal	animal	NN
cord-252528-rgnhfcbx	134	6	experiment	experiment	NN
cord-252528-rgnhfcbx	134	7	shows	show	VBZ
cord-252528-rgnhfcbx	134	8	that	that	IN
cord-252528-rgnhfcbx	134	9	IFN	IFN	NNP
cord-252528-rgnhfcbx	134	10	-	-	HYPH
cord-252528-rgnhfcbx	134	11	γ	γ	NN
cord-252528-rgnhfcbx	134	12	can	can	MD
cord-252528-rgnhfcbx	134	13	promote	promote	VB
cord-252528-rgnhfcbx	134	14	deep	deep	JJ
cord-252528-rgnhfcbx	134	15	venous	venous	JJ
cord-252528-rgnhfcbx	134	16	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	134	17	by	by	IN
cord-252528-rgnhfcbx	134	18	mediating	mediate	VBG
cord-252528-rgnhfcbx	134	19	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	134	20	extracellular	extracellular	JJ
cord-252528-rgnhfcbx	134	21	traps	trap	NNS
cord-252528-rgnhfcbx	134	22	(	(	-LRB-
cord-252528-rgnhfcbx	134	23	NETs	nets	NN
cord-252528-rgnhfcbx	134	24	)	)	-RRB-
cord-252528-rgnhfcbx	134	25	formation	formation	NN
cord-252528-rgnhfcbx	134	26	[	[	-LRB-
cord-252528-rgnhfcbx	134	27	46	46	CD
cord-252528-rgnhfcbx	134	28	]	]	-RRB-
cord-252528-rgnhfcbx	134	29	.	.	.
cord-252528-rgnhfcbx	135	1	After	after	IN
cord-252528-rgnhfcbx	135	2	thrombus	thrombus	NN
cord-252528-rgnhfcbx	135	3	formation	formation	NN
cord-252528-rgnhfcbx	135	4	,	,	,
cord-252528-rgnhfcbx	135	5	IFN	IFN	NNP
cord-252528-rgnhfcbx	135	6	-	-	HYPH
cord-252528-rgnhfcbx	135	7	γ	γ	NNP
cord-252528-rgnhfcbx	135	8	could	could	MD
cord-252528-rgnhfcbx	135	9	impede	impede	VB
cord-252528-rgnhfcbx	135	10	the	the	DT
cord-252528-rgnhfcbx	135	11	thrombus	thrombus	NN
cord-252528-rgnhfcbx	135	12	resolution	resolution	NN
cord-252528-rgnhfcbx	135	13	through	through	IN
cord-252528-rgnhfcbx	135	14	decreased	decrease	VBN
cord-252528-rgnhfcbx	135	15	VEGF	vegf	NN
cord-252528-rgnhfcbx	135	16	and	and	CC
cord-252528-rgnhfcbx	135	17	matrix	matrix	NN
cord-252528-rgnhfcbx	135	18	metalloproteinase	metalloproteinase	NN
cord-252528-rgnhfcbx	135	19	9	9	CD
cord-252528-rgnhfcbx	135	20	(	(	-LRB-
cord-252528-rgnhfcbx	135	21	Mmp9	Mmp9	NNP
cord-252528-rgnhfcbx	135	22	)	)	-RRB-
cord-252528-rgnhfcbx	135	23	expressions	expression	NNS
cord-252528-rgnhfcbx	135	24	in	in	IN
cord-252528-rgnhfcbx	135	25	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	135	26	mediated	mediate	VBN
cord-252528-rgnhfcbx	135	27	by	by	IN
cord-252528-rgnhfcbx	135	28	IFN	IFN	NNP
cord-252528-rgnhfcbx	135	29	-	-	HYPH
cord-252528-rgnhfcbx	135	30	γ	γ	NNP
cord-252528-rgnhfcbx	135	31	/STAT1	/STAT1	,
cord-252528-rgnhfcbx	135	32	signal	signal	NNP
cord-252528-rgnhfcbx	135	33	pathway	pathway	NN
cord-252528-rgnhfcbx	135	34	activation	activation	NN
cord-252528-rgnhfcbx	135	35	[	[	-LRB-
cord-252528-rgnhfcbx	135	36	47	47	CD
cord-252528-rgnhfcbx	135	37	]	]	-RRB-
cord-252528-rgnhfcbx	135	38	.	.	.
cord-252528-rgnhfcbx	136	1	Overall	overall	RB
cord-252528-rgnhfcbx	136	2	,	,	,
cord-252528-rgnhfcbx	136	3	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	136	4	contributes	contribute	VBZ
cord-252528-rgnhfcbx	136	5	to	to	IN
cord-252528-rgnhfcbx	136	6	a	a	DT
cord-252528-rgnhfcbx	136	7	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	136	8	state	state	NN
cord-252528-rgnhfcbx	136	9	by	by	IN
cord-252528-rgnhfcbx	136	10	enhancing	enhance	VBG
cord-252528-rgnhfcbx	136	11	the	the	DT
cord-252528-rgnhfcbx	136	12	activity	activity	NN
cord-252528-rgnhfcbx	136	13	and	and	CC
cord-252528-rgnhfcbx	136	14	production	production	NN
cord-252528-rgnhfcbx	136	15	of	of	IN
cord-252528-rgnhfcbx	136	16	platelets	platelet	NNS
cord-252528-rgnhfcbx	136	17	,	,	,
cord-252528-rgnhfcbx	136	18	promoting	promote	VBG
cord-252528-rgnhfcbx	136	19	an	an	DT
cord-252528-rgnhfcbx	136	20	imbalance	imbalance	NN
cord-252528-rgnhfcbx	136	21	between	between	IN
cord-252528-rgnhfcbx	136	22	plasma	plasma	NN
cord-252528-rgnhfcbx	136	23	levels	level	NNS
cord-252528-rgnhfcbx	136	24	of	of	IN
cord-252528-rgnhfcbx	136	25	coagulative	coagulative	JJ
cord-252528-rgnhfcbx	136	26	factors	factor	NNS
cord-252528-rgnhfcbx	136	27	and	and	CC
cord-252528-rgnhfcbx	136	28	anti	anti	JJ
cord-252528-rgnhfcbx	136	29	-	-	JJ
cord-252528-rgnhfcbx	136	30	coagulative	coagulative	JJ
cord-252528-rgnhfcbx	136	31	factors	factor	NNS
cord-252528-rgnhfcbx	136	32	,	,	,
cord-252528-rgnhfcbx	136	33	and	and	CC
cord-252528-rgnhfcbx	136	34	inducing	induce	VBG
cord-252528-rgnhfcbx	136	35	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	136	36	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	136	37	.	.	.
cord-252528-rgnhfcbx	137	1	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	137	2	induces	induce	VBZ
cord-252528-rgnhfcbx	137	3	thrombus	thrombus	NN
cord-252528-rgnhfcbx	137	4	formation	formation	NN
cord-252528-rgnhfcbx	137	5	by	by	IN
cord-252528-rgnhfcbx	137	6	increasing	increase	VBG
cord-252528-rgnhfcbx	137	7	platelet	platelet	NN
cord-252528-rgnhfcbx	137	8	production	production	NN
cord-252528-rgnhfcbx	137	9	and	and	CC
cord-252528-rgnhfcbx	137	10	activity	activity	NN
cord-252528-rgnhfcbx	137	11	.	.	.
cord-252528-rgnhfcbx	138	1	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	138	2	has	have	VBZ
cord-252528-rgnhfcbx	138	3	been	be	VBN
cord-252528-rgnhfcbx	138	4	shown	show	VBN
cord-252528-rgnhfcbx	138	5	to	to	TO
cord-252528-rgnhfcbx	138	6	promote	promote	VB
cord-252528-rgnhfcbx	138	7	a	a	DT
cord-252528-rgnhfcbx	138	8	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	138	9	state	state	NN
cord-252528-rgnhfcbx	138	10	and	and	CC
cord-252528-rgnhfcbx	138	11	accelerate	accelerate	VB
cord-252528-rgnhfcbx	138	12	blood	blood	NN
cord-252528-rgnhfcbx	138	13	clot	clot	NN
cord-252528-rgnhfcbx	138	14	formation	formation	NN
cord-252528-rgnhfcbx	138	15	via	via	IN
cord-252528-rgnhfcbx	138	16	whole	whole	JJ
cord-252528-rgnhfcbx	138	17	blood	blood	NN
cord-252528-rgnhfcbx	138	18	thromboelastography	thromboelastography	NN
cord-252528-rgnhfcbx	138	19	,	,	,
cord-252528-rgnhfcbx	138	20	as	as	IN
cord-252528-rgnhfcbx	138	21	evidenced	evidence	VBN
cord-252528-rgnhfcbx	138	22	by	by	IN
cord-252528-rgnhfcbx	138	23	the	the	DT
cord-252528-rgnhfcbx	138	24	markedly	markedly	RB
cord-252528-rgnhfcbx	138	25	reduced	reduce	VBN
cord-252528-rgnhfcbx	138	26	time	time	NN
cord-252528-rgnhfcbx	138	27	before	before	IN
cord-252528-rgnhfcbx	138	28	maximum	maximum	JJ
cord-252528-rgnhfcbx	138	29	velocity	velocity	NN
cord-252528-rgnhfcbx	138	30	of	of	IN
cord-252528-rgnhfcbx	138	31	clot	clot	NN
cord-252528-rgnhfcbx	138	32	growth	growth	NN
cord-252528-rgnhfcbx	138	33	(	(	-LRB-
cord-252528-rgnhfcbx	138	34	TMRTG	TMRTG	NNP
cord-252528-rgnhfcbx	138	35	)	)	-RRB-
cord-252528-rgnhfcbx	138	36	.	.	.
cord-252528-rgnhfcbx	139	1	The	the	DT
cord-252528-rgnhfcbx	139	2	IL-6-induced	il-6-induced	CD
cord-252528-rgnhfcbx	139	3	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	139	4	state	state	NN
cord-252528-rgnhfcbx	139	5	in	in	IN
cord-252528-rgnhfcbx	139	6	the	the	DT
cord-252528-rgnhfcbx	139	7	whole	whole	JJ
cord-252528-rgnhfcbx	139	8	blood	blood	NN
cord-252528-rgnhfcbx	139	9	has	have	VBZ
cord-252528-rgnhfcbx	139	10	been	be	VBN
cord-252528-rgnhfcbx	139	11	further	further	RB
cord-252528-rgnhfcbx	139	12	confirmed	confirm	VBN
cord-252528-rgnhfcbx	139	13	by	by	IN
cord-252528-rgnhfcbx	139	14	the	the	DT
cord-252528-rgnhfcbx	139	15	hyper	hyper	NN
cord-252528-rgnhfcbx	139	16	-	-	NN
cord-252528-rgnhfcbx	139	17	activation	activation	NN
cord-252528-rgnhfcbx	139	18	of	of	IN
cord-252528-rgnhfcbx	139	19	platelets	platelet	NNS
cord-252528-rgnhfcbx	139	20	under	under	IN
cord-252528-rgnhfcbx	139	21	scanning	scanning	NN
cord-252528-rgnhfcbx	139	22	electron	electron	NN
cord-252528-rgnhfcbx	139	23	microscopy	microscopy	NN
cord-252528-rgnhfcbx	139	24	[	[	-LRB-
cord-252528-rgnhfcbx	139	25	48	48	CD
cord-252528-rgnhfcbx	139	26	]	]	-RRB-
cord-252528-rgnhfcbx	139	27	.	.	.
cord-252528-rgnhfcbx	140	1	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	140	2	contributes	contribute	VBZ
cord-252528-rgnhfcbx	140	3	to	to	IN
cord-252528-rgnhfcbx	140	4	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	140	5	thrombocytosis	thrombocytosis	NN
cord-252528-rgnhfcbx	140	6	by	by	IN
cord-252528-rgnhfcbx	140	7	up	up	NN
cord-252528-rgnhfcbx	140	8	-	-	HYPH
cord-252528-rgnhfcbx	140	9	regulating	regulate	VBG
cord-252528-rgnhfcbx	140	10	thrombopoietin	thrombopoietin	XX
cord-252528-rgnhfcbx	140	11	(	(	-LRB-
cord-252528-rgnhfcbx	140	12	TPO	TPO	NNP
cord-252528-rgnhfcbx	140	13	)	)	-RRB-
cord-252528-rgnhfcbx	140	14	production	production	NN
cord-252528-rgnhfcbx	140	15	in	in	IN
cord-252528-rgnhfcbx	140	16	hepatocytes	hepatocyte	NNS
cord-252528-rgnhfcbx	140	17	,	,	,
cord-252528-rgnhfcbx	140	18	indicated	indicate	VBN
cord-252528-rgnhfcbx	140	19	by	by	IN
cord-252528-rgnhfcbx	140	20	in	in	IN
cord-252528-rgnhfcbx	140	21	vivo	vivo	NN
cord-252528-rgnhfcbx	140	22	experiments	experiment	NNS
cord-252528-rgnhfcbx	140	23	involving	involve	VBG
cord-252528-rgnhfcbx	140	24	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	140	25	administration	administration	NN
cord-252528-rgnhfcbx	140	26	and	and	CC
cord-252528-rgnhfcbx	140	27	TPO	TPO	NNP
cord-252528-rgnhfcbx	140	28	neutralization	neutralization	NN
cord-252528-rgnhfcbx	140	29	in	in	IN
cord-252528-rgnhfcbx	140	30	C57BL/10	C57BL/10	NNP
cord-252528-rgnhfcbx	140	31	mice	mouse	NNS
cord-252528-rgnhfcbx	140	32	[	[	-LRB-
cord-252528-rgnhfcbx	140	33	49	49	CD
cord-252528-rgnhfcbx	140	34	]	]	-RRB-
cord-252528-rgnhfcbx	140	35	.	.	.
cord-252528-rgnhfcbx	141	1	Increased	increase	VBN
cord-252528-rgnhfcbx	141	2	platelet	platelet	NN
cord-252528-rgnhfcbx	141	3	production	production	NN
cord-252528-rgnhfcbx	141	4	plays	play	VBZ
cord-252528-rgnhfcbx	141	5	a	a	DT
cord-252528-rgnhfcbx	141	6	role	role	NN
cord-252528-rgnhfcbx	141	7	in	in	IN
cord-252528-rgnhfcbx	141	8	promoting	promote	VBG
cord-252528-rgnhfcbx	141	9	primary	primary	JJ
cord-252528-rgnhfcbx	141	10	hemostasis	hemostasis	NN
cord-252528-rgnhfcbx	141	11	during	during	IN
cord-252528-rgnhfcbx	141	12	inflammation	inflammation	NN
cord-252528-rgnhfcbx	141	13	.	.	.
cord-252528-rgnhfcbx	142	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	142	2	,	,	,
cord-252528-rgnhfcbx	142	3	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	142	4	can	can	MD
cord-252528-rgnhfcbx	142	5	promote	promote	VB
cord-252528-rgnhfcbx	142	6	hypercoagulability	hypercoagulability	NN
cord-252528-rgnhfcbx	142	7	by	by	IN
cord-252528-rgnhfcbx	142	8	modulating	modulate	VBG
cord-252528-rgnhfcbx	142	9	plasma	plasma	NN
cord-252528-rgnhfcbx	142	10	levels	level	NNS
cord-252528-rgnhfcbx	142	11	of	of	IN
cord-252528-rgnhfcbx	142	12	coagulant	coagulant	NN
cord-252528-rgnhfcbx	142	13	factors	factor	NNS
cord-252528-rgnhfcbx	142	14	.	.	.
cord-252528-rgnhfcbx	143	1	In	in	IN
cord-252528-rgnhfcbx	143	2	vitro	vitro	FW
cord-252528-rgnhfcbx	143	3	evidence	evidence	NN
cord-252528-rgnhfcbx	143	4	has	have	VBZ
cord-252528-rgnhfcbx	143	5	suggested	suggest	VBN
cord-252528-rgnhfcbx	143	6	that	that	IN
cord-252528-rgnhfcbx	143	7	,	,	,
cord-252528-rgnhfcbx	143	8	in	in	IN
cord-252528-rgnhfcbx	143	9	ECs	ec	NNS
cord-252528-rgnhfcbx	143	10	and	and	CC
cord-252528-rgnhfcbx	143	11	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	143	12	,	,	,
cord-252528-rgnhfcbx	143	13	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	143	14	increases	increase	VBZ
cord-252528-rgnhfcbx	143	15	the	the	DT
cord-252528-rgnhfcbx	143	16	expression	expression	NN
cord-252528-rgnhfcbx	143	17	of	of	IN
cord-252528-rgnhfcbx	143	18	TF	TF	NNP
cord-252528-rgnhfcbx	143	19	,	,	,
cord-252528-rgnhfcbx	143	20	which	which	WDT
cord-252528-rgnhfcbx	143	21	initiates	initiate	VBZ
cord-252528-rgnhfcbx	143	22	the	the	DT
cord-252528-rgnhfcbx	143	23	activation	activation	NN
cord-252528-rgnhfcbx	143	24	of	of	IN
cord-252528-rgnhfcbx	143	25	extrinsic	extrinsic	JJ
cord-252528-rgnhfcbx	143	26	coagulation	coagulation	NN
cord-252528-rgnhfcbx	143	27	pathway	pathway	NN
cord-252528-rgnhfcbx	143	28	that	that	WDT
cord-252528-rgnhfcbx	143	29	is	be	VBZ
cord-252528-rgnhfcbx	143	30	responsible	responsible	JJ
cord-252528-rgnhfcbx	143	31	for	for	IN
cord-252528-rgnhfcbx	143	32	thrombus	thrombus	NN
cord-252528-rgnhfcbx	143	33	formation	formation	NN
cord-252528-rgnhfcbx	143	34	[	[	-LRB-
cord-252528-rgnhfcbx	143	35	50	50	CD
cord-252528-rgnhfcbx	143	36	,	,	,
cord-252528-rgnhfcbx	143	37	51	51	CD
cord-252528-rgnhfcbx	143	38	]	]	-RRB-
cord-252528-rgnhfcbx	143	39	.	.	.
cord-252528-rgnhfcbx	144	1	Results	result	NNS
cord-252528-rgnhfcbx	144	2	of	of	IN
cord-252528-rgnhfcbx	144	3	animal	animal	NN
cord-252528-rgnhfcbx	144	4	experiments	experiment	NNS
cord-252528-rgnhfcbx	144	5	also	also	RB
cord-252528-rgnhfcbx	144	6	confirm	confirm	VBP
cord-252528-rgnhfcbx	144	7	the	the	DT
cord-252528-rgnhfcbx	144	8	capability	capability	NN
cord-252528-rgnhfcbx	144	9	of	of	IN
cord-252528-rgnhfcbx	144	10	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	144	11	to	to	TO
cord-252528-rgnhfcbx	144	12	stimulate	stimulate	VB
cord-252528-rgnhfcbx	144	13	the	the	DT
cord-252528-rgnhfcbx	144	14	initiation	initiation	NN
cord-252528-rgnhfcbx	144	15	of	of	IN
cord-252528-rgnhfcbx	144	16	coagulation	coagulation	NN
cord-252528-rgnhfcbx	144	17	.	.	.
cord-252528-rgnhfcbx	145	1	In	in	IN
cord-252528-rgnhfcbx	145	2	response	response	NN
cord-252528-rgnhfcbx	145	3	to	to	IN
cord-252528-rgnhfcbx	145	4	an	an	DT
cord-252528-rgnhfcbx	145	5	Escherichia	Escherichia	NNP
cord-252528-rgnhfcbx	145	6	coli	coli	NNS
cord-252528-rgnhfcbx	145	7	(	(	-LRB-
cord-252528-rgnhfcbx	145	8	E	e	NN
cord-252528-rgnhfcbx	145	9	coli	coli	NNS
cord-252528-rgnhfcbx	145	10	.	.	.
cord-252528-rgnhfcbx	145	11	)	)	-RRB-
cord-252528-rgnhfcbx	146	1	endotoxin	endotoxin	NN
cord-252528-rgnhfcbx	146	2	injection	injection	NN
cord-252528-rgnhfcbx	146	3	,	,	,
cord-252528-rgnhfcbx	146	4	an	an	DT
cord-252528-rgnhfcbx	146	5	increase	increase	NN
cord-252528-rgnhfcbx	146	6	in	in	IN
cord-252528-rgnhfcbx	146	7	plasma	plasma	NN
cord-252528-rgnhfcbx	146	8	levels	level	NNS
cord-252528-rgnhfcbx	146	9	of	of	IN
cord-252528-rgnhfcbx	146	10	thrombin	thrombin	NN
cord-252528-rgnhfcbx	146	11	fragments	fragment	NNS
cord-252528-rgnhfcbx	146	12	F1	F1	NNP
cord-252528-rgnhfcbx	146	13	F2	f2	NN
cord-252528-rgnhfcbx	146	14	and	and	CC
cord-252528-rgnhfcbx	146	15	thrombin	thrombin	NN
cord-252528-rgnhfcbx	146	16	-	-	HYPH
cord-252528-rgnhfcbx	146	17	antithrombin	antithrombin	NN
cord-252528-rgnhfcbx	146	18	III	iii	CD
cord-252528-rgnhfcbx	146	19	complexes	complex	NNS
cord-252528-rgnhfcbx	146	20	,	,	,
cord-252528-rgnhfcbx	146	21	indicating	indicate	VBG
cord-252528-rgnhfcbx	146	22	coagulation	coagulation	NN
cord-252528-rgnhfcbx	146	23	activation	activation	NN
cord-252528-rgnhfcbx	146	24	,	,	,
cord-252528-rgnhfcbx	146	25	is	be	VBZ
cord-252528-rgnhfcbx	146	26	abrogated	abrogate	VBN
cord-252528-rgnhfcbx	146	27	by	by	IN
cord-252528-rgnhfcbx	146	28	a	a	DT
cord-252528-rgnhfcbx	146	29	simultaneous	simultaneous	JJ
cord-252528-rgnhfcbx	146	30	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	146	31	antibody	antibody	NN
cord-252528-rgnhfcbx	146	32	injection	injection	NN
cord-252528-rgnhfcbx	146	33	in	in	IN
cord-252528-rgnhfcbx	146	34	chimpanzees	chimpanzee	NNS
cord-252528-rgnhfcbx	146	35	[	[	-LRB-
cord-252528-rgnhfcbx	146	36	52	52	CD
cord-252528-rgnhfcbx	146	37	]	]	-RRB-
cord-252528-rgnhfcbx	146	38	.	.	.
cord-252528-rgnhfcbx	147	1	In	in	IN
cord-252528-rgnhfcbx	147	2	canine	canine	NN
cord-252528-rgnhfcbx	147	3	,	,	,
cord-252528-rgnhfcbx	147	4	following	follow	VBG
cord-252528-rgnhfcbx	147	5	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	147	6	injection	injection	NN
cord-252528-rgnhfcbx	147	7	,	,	,
cord-252528-rgnhfcbx	147	8	plasma	plasma	NN
cord-252528-rgnhfcbx	147	9	levels	level	NNS
cord-252528-rgnhfcbx	147	10	of	of	IN
cord-252528-rgnhfcbx	147	11	fibrinogen	fibrinogen	NN
cord-252528-rgnhfcbx	147	12	and	and	CC
cord-252528-rgnhfcbx	147	13	von	von	NNP
cord-252528-rgnhfcbx	147	14	Willebrand	Willebrand	NNP
cord-252528-rgnhfcbx	147	15	factor	factor	NN
cord-252528-rgnhfcbx	147	16	(	(	-LRB-
cord-252528-rgnhfcbx	147	17	vWf	vWf	NNS
cord-252528-rgnhfcbx	147	18	)	)	-RRB-
cord-252528-rgnhfcbx	147	19	are	be	VBP
cord-252528-rgnhfcbx	147	20	increased	increase	VBN
cord-252528-rgnhfcbx	147	21	,	,	,
cord-252528-rgnhfcbx	147	22	while	while	IN
cord-252528-rgnhfcbx	147	23	the	the	DT
cord-252528-rgnhfcbx	147	24	plasma	plasma	NN
cord-252528-rgnhfcbx	147	25	concentration	concentration	NN
cord-252528-rgnhfcbx	147	26	of	of	IN
cord-252528-rgnhfcbx	147	27	free	free	JJ
cord-252528-rgnhfcbx	147	28	protein	protein	NN
cord-252528-rgnhfcbx	147	29	S	S	NNP
cord-252528-rgnhfcbx	147	30	is	be	VBZ
cord-252528-rgnhfcbx	147	31	reduced	reduce	VBN
cord-252528-rgnhfcbx	147	32	,	,	,
cord-252528-rgnhfcbx	147	33	suggesting	suggest	VBG
cord-252528-rgnhfcbx	147	34	that	that	IN
cord-252528-rgnhfcbx	147	35	increasing	increase	VBG
cord-252528-rgnhfcbx	147	36	the	the	DT
cord-252528-rgnhfcbx	147	37	plasma	plasma	NN
cord-252528-rgnhfcbx	147	38	level	level	NN
cord-252528-rgnhfcbx	147	39	of	of	IN
cord-252528-rgnhfcbx	147	40	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	147	41	can	can	MD
cord-252528-rgnhfcbx	147	42	induce	induce	VB
cord-252528-rgnhfcbx	147	43	a	a	DT
cord-252528-rgnhfcbx	147	44	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	147	45	state	state	NN
cord-252528-rgnhfcbx	147	46	[	[	-LRB-
cord-252528-rgnhfcbx	147	47	53	53	CD
cord-252528-rgnhfcbx	147	48	]	]	-RRB-
cord-252528-rgnhfcbx	147	49	.	.	.
cord-252528-rgnhfcbx	148	1	Last	last	JJ
cord-252528-rgnhfcbx	148	2	but	but	CC
cord-252528-rgnhfcbx	148	3	not	not	RB
cord-252528-rgnhfcbx	148	4	least	least	JJS
cord-252528-rgnhfcbx	148	5	,	,	,
cord-252528-rgnhfcbx	148	6	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	148	7	signaling	signal	VBG
cord-252528-rgnhfcbx	148	8	in	in	IN
cord-252528-rgnhfcbx	148	9	ECs	ec	NNS
cord-252528-rgnhfcbx	148	10	results	result	NNS
cord-252528-rgnhfcbx	148	11	in	in	IN
cord-252528-rgnhfcbx	148	12	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	148	13	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	148	14	,	,	,
cord-252528-rgnhfcbx	148	15	increasing	increase	VBG
cord-252528-rgnhfcbx	148	16	the	the	DT
cord-252528-rgnhfcbx	148	17	risk	risk	NN
cord-252528-rgnhfcbx	148	18	of	of	IN
cord-252528-rgnhfcbx	148	19	vascular	vascular	JJ
cord-252528-rgnhfcbx	148	20	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	148	21	events	event	NNS
cord-252528-rgnhfcbx	148	22	.	.	.
cord-252528-rgnhfcbx	149	1	Although	although	IN
cord-252528-rgnhfcbx	149	2	ECs	ec	NNS
cord-252528-rgnhfcbx	149	3	do	do	VBP
cord-252528-rgnhfcbx	149	4	not	not	RB
cord-252528-rgnhfcbx	149	5	have	have	VB
cord-252528-rgnhfcbx	149	6	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	149	7	receptor	receptor	NN
cord-252528-rgnhfcbx	149	8	expression	expression	NN
cord-252528-rgnhfcbx	149	9	,	,	,
cord-252528-rgnhfcbx	149	10	they	-PRON-	PRP
cord-252528-rgnhfcbx	149	11	do	do	VBP
cord-252528-rgnhfcbx	149	12	have	have	VB
cord-252528-rgnhfcbx	149	13	the	the	DT
cord-252528-rgnhfcbx	149	14	expression	expression	NN
cord-252528-rgnhfcbx	149	15	of	of	IN
cord-252528-rgnhfcbx	149	16	glycoprotein	glycoprotein	NN
cord-252528-rgnhfcbx	149	17	130	130	CD
cord-252528-rgnhfcbx	149	18	(	(	-LRB-
cord-252528-rgnhfcbx	149	19	Gp130	Gp130	NNP
cord-252528-rgnhfcbx	149	20	)	)	-RRB-
cord-252528-rgnhfcbx	149	21	,	,	,
cord-252528-rgnhfcbx	149	22	which	which	WDT
cord-252528-rgnhfcbx	149	23	can	can	MD
cord-252528-rgnhfcbx	149	24	bind	bind	VB
cord-252528-rgnhfcbx	149	25	to	to	IN
cord-252528-rgnhfcbx	149	26	the	the	DT
cord-252528-rgnhfcbx	149	27	complex	complex	NN
cord-252528-rgnhfcbx	149	28	of	of	IN
cord-252528-rgnhfcbx	149	29	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	149	30	and	and	CC
cord-252528-rgnhfcbx	149	31	its	-PRON-	PRP$
cord-252528-rgnhfcbx	149	32	soluble	soluble	JJ
cord-252528-rgnhfcbx	149	33	receptor	receptor	NN
cord-252528-rgnhfcbx	149	34	sIL-6R	sil-6r	NN
cord-252528-rgnhfcbx	149	35	in	in	IN
cord-252528-rgnhfcbx	149	36	the	the	DT
cord-252528-rgnhfcbx	149	37	plasma	plasma	NN
cord-252528-rgnhfcbx	149	38	,	,	,
cord-252528-rgnhfcbx	149	39	allowing	allow	VBG
cord-252528-rgnhfcbx	149	40	ECs	ec	NNS
cord-252528-rgnhfcbx	149	41	to	to	TO
cord-252528-rgnhfcbx	149	42	respond	respond	VB
cord-252528-rgnhfcbx	149	43	to	to	IN
cord-252528-rgnhfcbx	149	44	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	149	45	stimulation	stimulation	NN
cord-252528-rgnhfcbx	149	46	[	[	-LRB-
cord-252528-rgnhfcbx	149	47	54	54	CD
cord-252528-rgnhfcbx	149	48	]	]	-RRB-
cord-252528-rgnhfcbx	149	49	.	.	.
cord-252528-rgnhfcbx	150	1	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	150	2	trans	trans	NNP
cord-252528-rgnhfcbx	150	3	-	-	HYPH
cord-252528-rgnhfcbx	150	4	signaling	signaling	NN
cord-252528-rgnhfcbx	150	5	can	can	MD
cord-252528-rgnhfcbx	150	6	activate	activate	VB
cord-252528-rgnhfcbx	150	7	vascular	vascular	JJ
cord-252528-rgnhfcbx	150	8	ECs	ec	NNS
cord-252528-rgnhfcbx	150	9	by	by	IN
cord-252528-rgnhfcbx	150	10	increasing	increase	VBG
cord-252528-rgnhfcbx	150	11	the	the	DT
cord-252528-rgnhfcbx	150	12	expressions	expression	NNS
cord-252528-rgnhfcbx	150	13	of	of	IN
cord-252528-rgnhfcbx	150	14	chemokines	chemokine	NNS
cord-252528-rgnhfcbx	150	15	and	and	CC
cord-252528-rgnhfcbx	150	16	cell	cell	NN
cord-252528-rgnhfcbx	150	17	adhesion	adhesion	NN
cord-252528-rgnhfcbx	150	18	molecules	molecule	NNS
cord-252528-rgnhfcbx	150	19	,	,	,
cord-252528-rgnhfcbx	150	20	as	as	RB
cord-252528-rgnhfcbx	150	21	well	well	RB
cord-252528-rgnhfcbx	150	22	as	as	IN
cord-252528-rgnhfcbx	150	23	the	the	DT
cord-252528-rgnhfcbx	150	24	secretion	secretion	NN
cord-252528-rgnhfcbx	150	25	of	of	IN
cord-252528-rgnhfcbx	150	26	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	150	27	by	by	IN
cord-252528-rgnhfcbx	150	28	the	the	DT
cord-252528-rgnhfcbx	150	29	vascular	vascular	JJ
cord-252528-rgnhfcbx	150	30	ECs	ECs	NNP
cord-252528-rgnhfcbx	150	31	,	,	,
cord-252528-rgnhfcbx	150	32	turning	turn	VBG
cord-252528-rgnhfcbx	150	33	the	the	DT
cord-252528-rgnhfcbx	150	34	physiologic	physiologic	JJ
cord-252528-rgnhfcbx	150	35	phenotype	phenotype	NN
cord-252528-rgnhfcbx	150	36	of	of	IN
cord-252528-rgnhfcbx	150	37	the	the	DT
cord-252528-rgnhfcbx	150	38	vascular	vascular	JJ
cord-252528-rgnhfcbx	150	39	ECs	ec	NNS
cord-252528-rgnhfcbx	150	40	into	into	IN
cord-252528-rgnhfcbx	150	41	the	the	DT
cord-252528-rgnhfcbx	150	42	pathologic	pathologic	JJ
cord-252528-rgnhfcbx	150	43	phenotype	phenotype	NN
cord-252528-rgnhfcbx	150	44	[	[	-LRB-
cord-252528-rgnhfcbx	150	45	54	54	CD
cord-252528-rgnhfcbx	150	46	]	]	-RRB-
cord-252528-rgnhfcbx	150	47	.	.	.
cord-252528-rgnhfcbx	151	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	151	2	,	,	,
cord-252528-rgnhfcbx	151	3	in	in	IN
cord-252528-rgnhfcbx	151	4	a	a	DT
cord-252528-rgnhfcbx	151	5	cell	cell	NN
cord-252528-rgnhfcbx	151	6	culture	culture	NN
cord-252528-rgnhfcbx	151	7	experiment	experiment	NN
cord-252528-rgnhfcbx	151	8	,	,	,
cord-252528-rgnhfcbx	151	9	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	151	10	trans	trans	NNP
cord-252528-rgnhfcbx	151	11	-	-	HYPH
cord-252528-rgnhfcbx	151	12	signaling	signal	VBG
cord-252528-rgnhfcbx	151	13	in	in	IN
cord-252528-rgnhfcbx	151	14	microvascular	microvascular	JJ
cord-252528-rgnhfcbx	151	15	ECs	ec	NNS
cord-252528-rgnhfcbx	151	16	leads	lead	VBZ
cord-252528-rgnhfcbx	151	17	to	to	IN
cord-252528-rgnhfcbx	151	18	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	151	19	damages	damage	NNS
cord-252528-rgnhfcbx	151	20	by	by	IN
cord-252528-rgnhfcbx	151	21	promoting	promote	VBG
cord-252528-rgnhfcbx	151	22	apoptosis	apoptosis	NN
cord-252528-rgnhfcbx	151	23	[	[	-LRB-
cord-252528-rgnhfcbx	151	24	55	55	CD
cord-252528-rgnhfcbx	151	25	]	]	-RRB-
cord-252528-rgnhfcbx	151	26	.	.	.
cord-252528-rgnhfcbx	152	1	Despite	despite	IN
cord-252528-rgnhfcbx	152	2	plenty	plenty	NN
cord-252528-rgnhfcbx	152	3	of	of	IN
cord-252528-rgnhfcbx	152	4	evidence	evidence	NN
cord-252528-rgnhfcbx	152	5	showing	show	VBG
cord-252528-rgnhfcbx	152	6	the	the	DT
cord-252528-rgnhfcbx	152	7	contribution	contribution	NN
cord-252528-rgnhfcbx	152	8	of	of	IN
cord-252528-rgnhfcbx	152	9	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	152	10	to	to	TO
cord-252528-rgnhfcbx	152	11	increased	increase	VBN
cord-252528-rgnhfcbx	152	12	blood	blood	NN
cord-252528-rgnhfcbx	152	13	coagulability	coagulability	NN
cord-252528-rgnhfcbx	152	14	and	and	CC
cord-252528-rgnhfcbx	152	15	thrombus	thrombus	NN
cord-252528-rgnhfcbx	152	16	formation	formation	NN
cord-252528-rgnhfcbx	152	17	,	,	,
cord-252528-rgnhfcbx	152	18	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	152	19	could	could	MD
cord-252528-rgnhfcbx	152	20	also	also	RB
cord-252528-rgnhfcbx	152	21	be	be	VB
cord-252528-rgnhfcbx	152	22	necessary	necessary	JJ
cord-252528-rgnhfcbx	152	23	for	for	IN
cord-252528-rgnhfcbx	152	24	venous	venous	JJ
cord-252528-rgnhfcbx	152	25	thrombus	thrombus	NN
cord-252528-rgnhfcbx	152	26	resolution	resolution	NN
cord-252528-rgnhfcbx	152	27	by	by	IN
cord-252528-rgnhfcbx	152	28	recruiting	recruit	VBG
cord-252528-rgnhfcbx	152	29	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	152	30	and	and	CC
cord-252528-rgnhfcbx	152	31	enhancing	enhance	VBG
cord-252528-rgnhfcbx	152	32	expressions	expression	NNS
cord-252528-rgnhfcbx	152	33	of	of	IN
cord-252528-rgnhfcbx	152	34	Mmp2	Mmp2	NNP
cord-252528-rgnhfcbx	152	35	,	,	,
cord-252528-rgnhfcbx	152	36	Mmp9	Mmp9	NNP
cord-252528-rgnhfcbx	152	37	,	,	,
cord-252528-rgnhfcbx	152	38	and	and	CC
cord-252528-rgnhfcbx	152	39	urokinase	urokinase	NN
cord-252528-rgnhfcbx	152	40	-	-	HYPH
cord-252528-rgnhfcbx	152	41	type	type	NN
cord-252528-rgnhfcbx	152	42	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	152	43	activator	activator	NN
cord-252528-rgnhfcbx	152	44	(	(	-LRB-
cord-252528-rgnhfcbx	152	45	Plau	Plau	NNP
cord-252528-rgnhfcbx	152	46	)	)	-RRB-
cord-252528-rgnhfcbx	152	47	through	through	IN
cord-252528-rgnhfcbx	152	48	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	152	49	/	/	SYM
cord-252528-rgnhfcbx	152	50	STAT3	STAT3	NNP
cord-252528-rgnhfcbx	152	51	signaling	signal	VBG
cord-252528-rgnhfcbx	152	52	in	in	IN
cord-252528-rgnhfcbx	152	53	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	152	54	[	[	-LRB-
cord-252528-rgnhfcbx	152	55	56	56	CD
cord-252528-rgnhfcbx	152	56	]	]	-RRB-
cord-252528-rgnhfcbx	152	57	.	.	.
cord-252528-rgnhfcbx	153	1	However	however	RB
cord-252528-rgnhfcbx	153	2	,	,	,
cord-252528-rgnhfcbx	153	3	the	the	DT
cord-252528-rgnhfcbx	153	4	exact	exact	JJ
cord-252528-rgnhfcbx	153	5	role	role	NN
cord-252528-rgnhfcbx	153	6	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	153	7	plays	play	VBZ
cord-252528-rgnhfcbx	153	8	in	in	IN
cord-252528-rgnhfcbx	153	9	thrombus	thrombus	NN
cord-252528-rgnhfcbx	153	10	resolution	resolution	NN
cord-252528-rgnhfcbx	153	11	can	can	MD
cord-252528-rgnhfcbx	153	12	be	be	VB
cord-252528-rgnhfcbx	153	13	controversial	controversial	JJ
cord-252528-rgnhfcbx	153	14	because	because	IN
cord-252528-rgnhfcbx	153	15	of	of	IN
cord-252528-rgnhfcbx	153	16	the	the	DT
cord-252528-rgnhfcbx	153	17	in	in	FW
cord-252528-rgnhfcbx	153	18	vitro	vitro	FW
cord-252528-rgnhfcbx	153	19	evidence	evidence	NN
cord-252528-rgnhfcbx	153	20	showing	show	VBG
cord-252528-rgnhfcbx	153	21	up	up	RP
cord-252528-rgnhfcbx	153	22	-	-	HYPH
cord-252528-rgnhfcbx	153	23	regulated	regulated	JJ
cord-252528-rgnhfcbx	153	24	PAI-1	PAI-1	NNP
cord-252528-rgnhfcbx	153	25	expression	expression	NN
cord-252528-rgnhfcbx	153	26	in	in	IN
cord-252528-rgnhfcbx	153	27	adipose	adipose	JJ
cord-252528-rgnhfcbx	153	28	tissue	tissue	NN
cord-252528-rgnhfcbx	153	29	by	by	IN
cord-252528-rgnhfcbx	153	30	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	153	31	[	[	-LRB-
cord-252528-rgnhfcbx	153	32	57	57	CD
cord-252528-rgnhfcbx	153	33	]	]	-RRB-
cord-252528-rgnhfcbx	153	34	.	.	.
cord-252528-rgnhfcbx	154	1	The	the	DT
cord-252528-rgnhfcbx	154	2	role	role	NN
cord-252528-rgnhfcbx	154	3	and	and	CC
cord-252528-rgnhfcbx	154	4	mechanism	mechanism	NN
cord-252528-rgnhfcbx	154	5	of	of	IN
cord-252528-rgnhfcbx	154	6	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	154	7	production	production	NN
cord-252528-rgnhfcbx	154	8	during	during	IN
cord-252528-rgnhfcbx	154	9	acute	acute	JJ
cord-252528-rgnhfcbx	154	10	virus	virus	NN
cord-252528-rgnhfcbx	154	11	infection	infection	NN
cord-252528-rgnhfcbx	154	12	were	be	VBD
cord-252528-rgnhfcbx	154	13	elegantly	elegantly	RB
cord-252528-rgnhfcbx	154	14	reviewed	review	VBN
cord-252528-rgnhfcbx	154	15	by	by	IN
cord-252528-rgnhfcbx	154	16	José	José	NNP
cord-252528-rgnhfcbx	154	17	M.	M.	NNP
cord-252528-rgnhfcbx	154	18	Rojas	Rojas	NNP
cord-252528-rgnhfcbx	154	19	et	et	NNP
cord-252528-rgnhfcbx	154	20	al	al	NNP
cord-252528-rgnhfcbx	154	21	.	.	.
cord-252528-rgnhfcbx	155	1	[	[	-LRB-
cord-252528-rgnhfcbx	155	2	58	58	CD
cord-252528-rgnhfcbx	155	3	]	]	-RRB-
cord-252528-rgnhfcbx	155	4	.	.	.
cord-252528-rgnhfcbx	156	1	By	by	IN
cord-252528-rgnhfcbx	156	2	mediating	mediate	VBG
cord-252528-rgnhfcbx	156	3	negative	negative	JJ
cord-252528-rgnhfcbx	156	4	regulation	regulation	NN
cord-252528-rgnhfcbx	156	5	of	of	IN
cord-252528-rgnhfcbx	156	6	MHC	MHC	NNP
cord-252528-rgnhfcbx	156	7	II	II	NNP
cord-252528-rgnhfcbx	156	8	expression	expression	NN
cord-252528-rgnhfcbx	156	9	on	on	IN
cord-252528-rgnhfcbx	156	10	antigen	antigen	NN
cord-252528-rgnhfcbx	156	11	-	-	HYPH
cord-252528-rgnhfcbx	156	12	presenting	present	VBG
cord-252528-rgnhfcbx	156	13	cells	cell	NNS
cord-252528-rgnhfcbx	156	14	,	,	,
cord-252528-rgnhfcbx	156	15	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	156	16	can	can	MD
cord-252528-rgnhfcbx	156	17	impair	impair	VB
cord-252528-rgnhfcbx	156	18	the	the	DT
cord-252528-rgnhfcbx	156	19	priming	priming	NN
cord-252528-rgnhfcbx	156	20	of	of	IN
cord-252528-rgnhfcbx	156	21	Th1	th1	NN
cord-252528-rgnhfcbx	156	22	,	,	,
cord-252528-rgnhfcbx	156	23	which	which	WDT
cord-252528-rgnhfcbx	156	24	plays	play	VBZ
cord-252528-rgnhfcbx	156	25	a	a	DT
cord-252528-rgnhfcbx	156	26	vital	vital	JJ
cord-252528-rgnhfcbx	156	27	role	role	NN
cord-252528-rgnhfcbx	156	28	in	in	IN
cord-252528-rgnhfcbx	156	29	controlling	control	VBG
cord-252528-rgnhfcbx	156	30	virus	virus	NN
cord-252528-rgnhfcbx	156	31	infections	infection	NNS
cord-252528-rgnhfcbx	156	32	by	by	IN
cord-252528-rgnhfcbx	156	33	facilitating	facilitate	VBG
cord-252528-rgnhfcbx	156	34	the	the	DT
cord-252528-rgnhfcbx	156	35	effector	effector	NN
cord-252528-rgnhfcbx	156	36	functions	function	NNS
cord-252528-rgnhfcbx	156	37	of	of	IN
cord-252528-rgnhfcbx	156	38	cytotoxic	cytotoxic	JJ
cord-252528-rgnhfcbx	156	39	leukocytes	leukocyte	NNS
cord-252528-rgnhfcbx	156	40	and	and	CC
cord-252528-rgnhfcbx	156	41	lymphocytes	lymphocyte	NNS
cord-252528-rgnhfcbx	156	42	[	[	-LRB-
cord-252528-rgnhfcbx	156	43	58	58	CD
cord-252528-rgnhfcbx	156	44	,	,	,
cord-252528-rgnhfcbx	156	45	59	59	CD
cord-252528-rgnhfcbx	156	46	]	]	-RRB-
cord-252528-rgnhfcbx	156	47	.	.	.
cord-252528-rgnhfcbx	157	1	Although	although	IN
cord-252528-rgnhfcbx	157	2	it	-PRON-	PRP
cord-252528-rgnhfcbx	157	3	is	be	VBZ
cord-252528-rgnhfcbx	157	4	unclear	unclear	JJ
cord-252528-rgnhfcbx	157	5	whether	whether	IN
cord-252528-rgnhfcbx	157	6	the	the	DT
cord-252528-rgnhfcbx	157	7	elevation	elevation	NN
cord-252528-rgnhfcbx	157	8	of	of	IN
cord-252528-rgnhfcbx	157	9	serum	serum	NN
cord-252528-rgnhfcbx	157	10	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	157	11	in	in	IN
cord-252528-rgnhfcbx	157	12	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	157	13	patients	patient	NNS
cord-252528-rgnhfcbx	157	14	is	be	VBZ
cord-252528-rgnhfcbx	157	15	a	a	DT
cord-252528-rgnhfcbx	157	16	mechanism	mechanism	NN
cord-252528-rgnhfcbx	157	17	by	by	IN
cord-252528-rgnhfcbx	157	18	which	which	WDT
cord-252528-rgnhfcbx	157	19	SARS	SARS	NNP
cord-252528-rgnhfcbx	157	20	-	-	:
cord-252528-rgnhfcbx	157	21	COV-2	COV-2	NNP
cord-252528-rgnhfcbx	157	22	circumvent	circumvent	VB
cord-252528-rgnhfcbx	157	23	the	the	DT
cord-252528-rgnhfcbx	157	24	surveillance	surveillance	NN
cord-252528-rgnhfcbx	157	25	of	of	IN
cord-252528-rgnhfcbx	157	26	adaptive	adaptive	JJ
cord-252528-rgnhfcbx	157	27	immunity	immunity	NN
cord-252528-rgnhfcbx	157	28	,	,	,
cord-252528-rgnhfcbx	157	29	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	157	30	enhancement	enhancement	NN
cord-252528-rgnhfcbx	157	31	in	in	IN
cord-252528-rgnhfcbx	157	32	severe	severe	JJ
cord-252528-rgnhfcbx	157	33	cases	case	NNS
cord-252528-rgnhfcbx	157	34	is	be	VBZ
cord-252528-rgnhfcbx	157	35	likely	likely	RB
cord-252528-rgnhfcbx	157	36	a	a	DT
cord-252528-rgnhfcbx	157	37	compensatory	compensatory	JJ
cord-252528-rgnhfcbx	157	38	mechanism	mechanism	NN
cord-252528-rgnhfcbx	157	39	to	to	TO
cord-252528-rgnhfcbx	157	40	quench	quench	VB
cord-252528-rgnhfcbx	157	41	the	the	DT
cord-252528-rgnhfcbx	157	42	over	over	RB
cord-252528-rgnhfcbx	157	43	-	-	HYPH
cord-252528-rgnhfcbx	157	44	activated	activate	VBN
cord-252528-rgnhfcbx	157	45	inflammation	inflammation	NN
cord-252528-rgnhfcbx	157	46	,	,	,
cord-252528-rgnhfcbx	157	47	having	have	VBG
cord-252528-rgnhfcbx	157	48	an	an	DT
cord-252528-rgnhfcbx	157	49	inhibitory	inhibitory	JJ
cord-252528-rgnhfcbx	157	50	effect	effect	NN
cord-252528-rgnhfcbx	157	51	on	on	IN
cord-252528-rgnhfcbx	157	52	coagulation	coagulation	NN
cord-252528-rgnhfcbx	157	53	and	and	CC
cord-252528-rgnhfcbx	157	54	thrombus	thrombus	NN
cord-252528-rgnhfcbx	157	55	formation	formation	NN
cord-252528-rgnhfcbx	157	56	.	.	.
cord-252528-rgnhfcbx	158	1	Because	because	IN
cord-252528-rgnhfcbx	158	2	of	of	IN
cord-252528-rgnhfcbx	158	3	the	the	DT
cord-252528-rgnhfcbx	158	4	anti	anti	JJ
cord-252528-rgnhfcbx	158	5	-	-	JJ
cord-252528-rgnhfcbx	158	6	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	158	7	function	function	NN
cord-252528-rgnhfcbx	158	8	of	of	IN
cord-252528-rgnhfcbx	158	9	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	158	10	,	,	,
cord-252528-rgnhfcbx	158	11	it	-PRON-	PRP
cord-252528-rgnhfcbx	158	12	could	could	MD
cord-252528-rgnhfcbx	158	13	prevent	prevent	VB
cord-252528-rgnhfcbx	158	14	vascular	vascular	JJ
cord-252528-rgnhfcbx	158	15	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	158	16	by	by	IN
cord-252528-rgnhfcbx	158	17	alleviating	alleviate	VBG
cord-252528-rgnhfcbx	158	18	the	the	DT
cord-252528-rgnhfcbx	158	19	pro	pro	JJ
cord-252528-rgnhfcbx	158	20	-	-	JJ
cord-252528-rgnhfcbx	158	21	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	158	22	effects	effect	NNS
cord-252528-rgnhfcbx	158	23	associated	associate	VBN
cord-252528-rgnhfcbx	158	24	with	with	IN
cord-252528-rgnhfcbx	158	25	pro	pro	JJ
cord-252528-rgnhfcbx	158	26	-	-	JJ
cord-252528-rgnhfcbx	158	27	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	158	28	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	158	29	[	[	-LRB-
cord-252528-rgnhfcbx	158	30	40	40	CD
cord-252528-rgnhfcbx	158	31	,	,	,
cord-252528-rgnhfcbx	158	32	58	58	CD
cord-252528-rgnhfcbx	158	33	]	]	-RRB-
cord-252528-rgnhfcbx	158	34	.	.	.
cord-252528-rgnhfcbx	159	1	By	by	IN
cord-252528-rgnhfcbx	159	2	inhibiting	inhibit	VBG
cord-252528-rgnhfcbx	159	3	the	the	DT
cord-252528-rgnhfcbx	159	4	production	production	NN
cord-252528-rgnhfcbx	159	5	of	of	IN
cord-252528-rgnhfcbx	159	6	proinflammatory	proinflammatory	JJ
cord-252528-rgnhfcbx	159	7	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	159	8	,	,	,
cord-252528-rgnhfcbx	159	9	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	159	10	can	can	MD
cord-252528-rgnhfcbx	159	11	indirectly	indirectly	RB
cord-252528-rgnhfcbx	159	12	decrease	decrease	VB
cord-252528-rgnhfcbx	159	13	mitochondrial	mitochondrial	JJ
cord-252528-rgnhfcbx	159	14	ROS	ROS	NNP
cord-252528-rgnhfcbx	159	15	production	production	NN
cord-252528-rgnhfcbx	159	16	in	in	IN
cord-252528-rgnhfcbx	159	17	ECs	ECs	NNP
cord-252528-rgnhfcbx	159	18	,	,	,
cord-252528-rgnhfcbx	159	19	reducing	reduce	VBG
cord-252528-rgnhfcbx	159	20	the	the	DT
cord-252528-rgnhfcbx	159	21	acute	acute	JJ
cord-252528-rgnhfcbx	159	22	vascular	vascular	JJ
cord-252528-rgnhfcbx	159	23	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	159	24	cell	cell	NN
cord-252528-rgnhfcbx	159	25	activation	activation	NN
cord-252528-rgnhfcbx	159	26	[	[	-LRB-
cord-252528-rgnhfcbx	159	27	60	60	CD
cord-252528-rgnhfcbx	159	28	]	]	-RRB-
cord-252528-rgnhfcbx	159	29	.	.	.
cord-252528-rgnhfcbx	160	1	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	160	2	is	be	VBZ
cord-252528-rgnhfcbx	160	3	elevated	elevate	VBN
cord-252528-rgnhfcbx	160	4	in	in	IN
cord-252528-rgnhfcbx	160	5	response	response	NN
cord-252528-rgnhfcbx	160	6	to	to	IN
cord-252528-rgnhfcbx	160	7	venous	venous	JJ
cord-252528-rgnhfcbx	160	8	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	160	9	in	in	IN
cord-252528-rgnhfcbx	160	10	the	the	DT
cord-252528-rgnhfcbx	160	11	vascular	vascular	JJ
cord-252528-rgnhfcbx	160	12	wall	wall	NN
cord-252528-rgnhfcbx	160	13	,	,	,
cord-252528-rgnhfcbx	160	14	playing	play	VBG
cord-252528-rgnhfcbx	160	15	a	a	DT
cord-252528-rgnhfcbx	160	16	role	role	NN
cord-252528-rgnhfcbx	160	17	in	in	IN
cord-252528-rgnhfcbx	160	18	suppressing	suppress	VBG
cord-252528-rgnhfcbx	160	19	vascular	vascular	JJ
cord-252528-rgnhfcbx	160	20	inflammation	inflammation	NN
cord-252528-rgnhfcbx	160	21	and	and	CC
cord-252528-rgnhfcbx	160	22	reducing	reduce	VBG
cord-252528-rgnhfcbx	160	23	venous	venous	JJ
cord-252528-rgnhfcbx	160	24	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	160	25	,	,	,
cord-252528-rgnhfcbx	160	26	as	as	IN
cord-252528-rgnhfcbx	160	27	evidenced	evidence	VBN
cord-252528-rgnhfcbx	160	28	by	by	IN
cord-252528-rgnhfcbx	160	29	animal	animal	NN
cord-252528-rgnhfcbx	160	30	experiments	experiment	NNS
cord-252528-rgnhfcbx	160	31	in	in	IN
cord-252528-rgnhfcbx	160	32	rats	rat	NNS
cord-252528-rgnhfcbx	160	33	[	[	-LRB-
cord-252528-rgnhfcbx	160	34	61	61	CD
cord-252528-rgnhfcbx	160	35	]	]	-RRB-
cord-252528-rgnhfcbx	160	36	.	.	.
cord-252528-rgnhfcbx	161	1	In	in	IN
cord-252528-rgnhfcbx	161	2	a	a	DT
cord-252528-rgnhfcbx	161	3	double	double	RB
cord-252528-rgnhfcbx	161	4	-	-	HYPH
cord-252528-rgnhfcbx	161	5	blinded	blinded	JJ
cord-252528-rgnhfcbx	161	6	cohort	cohort	NN
cord-252528-rgnhfcbx	161	7	study	study	NN
cord-252528-rgnhfcbx	161	8	involving	involve	VBG
cord-252528-rgnhfcbx	161	9	12	12	CD
cord-252528-rgnhfcbx	161	10	healthy	healthy	JJ
cord-252528-rgnhfcbx	161	11	volunteers	volunteer	NNS
cord-252528-rgnhfcbx	161	12	,	,	,
cord-252528-rgnhfcbx	161	13	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	161	14	injection	injection	NN
cord-252528-rgnhfcbx	161	15	has	have	VBZ
cord-252528-rgnhfcbx	161	16	resulted	result	VBN
cord-252528-rgnhfcbx	161	17	in	in	IN
cord-252528-rgnhfcbx	161	18	decreased	decrease	VBN
cord-252528-rgnhfcbx	161	19	bone	bone	NN
cord-252528-rgnhfcbx	161	20	marrow	marrow	NN
cord-252528-rgnhfcbx	161	21	platelet	platelet	NN
cord-252528-rgnhfcbx	161	22	production	production	NN
cord-252528-rgnhfcbx	161	23	compared	compare	VBN
cord-252528-rgnhfcbx	161	24	to	to	IN
cord-252528-rgnhfcbx	161	25	placebo	placebo	NN
cord-252528-rgnhfcbx	161	26	,	,	,
cord-252528-rgnhfcbx	161	27	therefore	therefore	RB
cord-252528-rgnhfcbx	161	28	reducing	reduce	VBG
cord-252528-rgnhfcbx	161	29	the	the	DT
cord-252528-rgnhfcbx	161	30	risk	risk	NN
cord-252528-rgnhfcbx	161	31	of	of	IN
cord-252528-rgnhfcbx	161	32	thrombus	thrombus	NN
cord-252528-rgnhfcbx	161	33	formation	formation	NN
cord-252528-rgnhfcbx	161	34	[	[	-LRB-
cord-252528-rgnhfcbx	161	35	62	62	CD
cord-252528-rgnhfcbx	161	36	]	]	-RRB-
cord-252528-rgnhfcbx	161	37	.	.	.
cord-252528-rgnhfcbx	162	1	A	a	DT
cord-252528-rgnhfcbx	162	2	clinical	clinical	JJ
cord-252528-rgnhfcbx	162	3	study	study	NN
cord-252528-rgnhfcbx	162	4	has	have	VBZ
cord-252528-rgnhfcbx	162	5	further	further	RB
cord-252528-rgnhfcbx	162	6	revealed	reveal	VBN
cord-252528-rgnhfcbx	162	7	the	the	DT
cord-252528-rgnhfcbx	162	8	association	association	NN
cord-252528-rgnhfcbx	162	9	between	between	IN
cord-252528-rgnhfcbx	162	10	decreased	decrease	VBD
cord-252528-rgnhfcbx	162	11	serum	serum	NN
cord-252528-rgnhfcbx	162	12	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	162	13	and	and	CC
cord-252528-rgnhfcbx	162	14	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	162	15	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	162	16	in	in	IN
cord-252528-rgnhfcbx	162	17	patients	patient	NNS
cord-252528-rgnhfcbx	162	18	with	with	IN
cord-252528-rgnhfcbx	162	19	venous	venous	JJ
cord-252528-rgnhfcbx	162	20	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	162	21	[	[	-LRB-
cord-252528-rgnhfcbx	162	22	63	63	CD
cord-252528-rgnhfcbx	162	23	]	]	-RRB-
cord-252528-rgnhfcbx	162	24	.	.	.
cord-252528-rgnhfcbx	163	1	By	by	IN
cord-252528-rgnhfcbx	163	2	targeting	target	VBG
cord-252528-rgnhfcbx	163	3	the	the	DT
cord-252528-rgnhfcbx	163	4	excessively	excessively	RB
cord-252528-rgnhfcbx	163	5	released	release	VBN
cord-252528-rgnhfcbx	163	6	pro	pro	JJ
cord-252528-rgnhfcbx	163	7	-	-	JJ
cord-252528-rgnhfcbx	163	8	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	163	9	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	163	10	in	in	IN
cord-252528-rgnhfcbx	163	11	severe	severe	JJ
cord-252528-rgnhfcbx	163	12	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	163	13	,	,	,
cord-252528-rgnhfcbx	163	14	anti	anti	JJ
cord-252528-rgnhfcbx	163	15	-	-	JJ
cord-252528-rgnhfcbx	163	16	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	163	17	therapy	therapy	NN
cord-252528-rgnhfcbx	163	18	can	can	MD
cord-252528-rgnhfcbx	163	19	theoretically	theoretically	RB
cord-252528-rgnhfcbx	163	20	alleviate	alleviate	VB
cord-252528-rgnhfcbx	163	21	the	the	DT
cord-252528-rgnhfcbx	163	22	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	163	23	state	state	NN
cord-252528-rgnhfcbx	163	24	.	.	.
cord-252528-rgnhfcbx	164	1	Currently	currently	RB
cord-252528-rgnhfcbx	164	2	,	,	,
cord-252528-rgnhfcbx	164	3	it	-PRON-	PRP
cord-252528-rgnhfcbx	164	4	is	be	VBZ
cord-252528-rgnhfcbx	164	5	believed	believe	VBN
cord-252528-rgnhfcbx	164	6	that	that	IN
cord-252528-rgnhfcbx	164	7	the	the	DT
cord-252528-rgnhfcbx	164	8	timing	timing	NN
cord-252528-rgnhfcbx	164	9	of	of	IN
cord-252528-rgnhfcbx	164	10	anti	anti	JJ
cord-252528-rgnhfcbx	164	11	-	-	JJ
cord-252528-rgnhfcbx	164	12	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	164	13	therapy	therapy	NN
cord-252528-rgnhfcbx	164	14	is	be	VBZ
cord-252528-rgnhfcbx	164	15	an	an	DT
cord-252528-rgnhfcbx	164	16	essential	essential	JJ
cord-252528-rgnhfcbx	164	17	factor	factor	NN
cord-252528-rgnhfcbx	164	18	to	to	TO
cord-252528-rgnhfcbx	164	19	be	be	VB
cord-252528-rgnhfcbx	164	20	considered	consider	VBN
cord-252528-rgnhfcbx	164	21	when	when	WRB
cord-252528-rgnhfcbx	164	22	weighing	weigh	VBG
cord-252528-rgnhfcbx	164	23	the	the	DT
cord-252528-rgnhfcbx	164	24	risks	risk	NNS
cord-252528-rgnhfcbx	164	25	and	and	CC
cord-252528-rgnhfcbx	164	26	benefits	benefit	NNS
cord-252528-rgnhfcbx	164	27	for	for	IN
cord-252528-rgnhfcbx	164	28	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	164	29	patients	patient	NNS
cord-252528-rgnhfcbx	164	30	.	.	.
cord-252528-rgnhfcbx	165	1	During	during	IN
cord-252528-rgnhfcbx	165	2	the	the	DT
cord-252528-rgnhfcbx	165	3	incubation	incubation	NN
cord-252528-rgnhfcbx	165	4	period	period	NN
cord-252528-rgnhfcbx	165	5	and	and	CC
cord-252528-rgnhfcbx	165	6	the	the	DT
cord-252528-rgnhfcbx	165	7	non	non	JJ
cord-252528-rgnhfcbx	165	8	-	-	JJ
cord-252528-rgnhfcbx	165	9	severe	severe	JJ
cord-252528-rgnhfcbx	165	10	symptomatic	symptomatic	JJ
cord-252528-rgnhfcbx	165	11	stage	stage	NN
cord-252528-rgnhfcbx	165	12	of	of	IN
cord-252528-rgnhfcbx	165	13	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	165	14	,	,	,
cord-252528-rgnhfcbx	165	15	anti	anti	JJ
cord-252528-rgnhfcbx	165	16	-	-	JJ
cord-252528-rgnhfcbx	165	17	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	165	18	therapy	therapy	NN
cord-252528-rgnhfcbx	165	19	can	can	MD
cord-252528-rgnhfcbx	165	20	impair	impair	VB
cord-252528-rgnhfcbx	165	21	the	the	DT
cord-252528-rgnhfcbx	165	22	antiviral	antiviral	JJ
cord-252528-rgnhfcbx	165	23	immune	immune	JJ
cord-252528-rgnhfcbx	165	24	response	response	NN
cord-252528-rgnhfcbx	165	25	,	,	,
cord-252528-rgnhfcbx	165	26	increasing	increase	VBG
cord-252528-rgnhfcbx	165	27	the	the	DT
cord-252528-rgnhfcbx	165	28	risk	risk	NN
cord-252528-rgnhfcbx	165	29	of	of	IN
cord-252528-rgnhfcbx	165	30	aggravating	aggravate	VBG
cord-252528-rgnhfcbx	165	31	disease	disease	NN
cord-252528-rgnhfcbx	165	32	severity	severity	NN
cord-252528-rgnhfcbx	165	33	;	;	:
cord-252528-rgnhfcbx	165	34	however	however	RB
cord-252528-rgnhfcbx	165	35	,	,	,
cord-252528-rgnhfcbx	165	36	anti	anti	JJ
cord-252528-rgnhfcbx	165	37	-	-	JJ
cord-252528-rgnhfcbx	165	38	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	165	39	therapy	therapy	NN
cord-252528-rgnhfcbx	165	40	in	in	IN
cord-252528-rgnhfcbx	165	41	the	the	DT
cord-252528-rgnhfcbx	165	42	severe	severe	JJ
cord-252528-rgnhfcbx	165	43	stage	stage	NN
cord-252528-rgnhfcbx	165	44	of	of	IN
cord-252528-rgnhfcbx	165	45	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	165	46	,	,	,
cord-252528-rgnhfcbx	165	47	when	when	WRB
cord-252528-rgnhfcbx	165	48	the	the	DT
cord-252528-rgnhfcbx	165	49	viral	viral	JJ
cord-252528-rgnhfcbx	165	50	load	load	NN
cord-252528-rgnhfcbx	165	51	is	be	VBZ
cord-252528-rgnhfcbx	165	52	high	high	JJ
cord-252528-rgnhfcbx	165	53	and	and	CC
cord-252528-rgnhfcbx	165	54	the	the	DT
cord-252528-rgnhfcbx	165	55	optimal	optimal	JJ
cord-252528-rgnhfcbx	165	56	time	time	NN
cord-252528-rgnhfcbx	165	57	window	window	NN
cord-252528-rgnhfcbx	165	58	for	for	IN
cord-252528-rgnhfcbx	165	59	virus	virus	NN
cord-252528-rgnhfcbx	165	60	clearance	clearance	NN
cord-252528-rgnhfcbx	165	61	is	be	VBZ
cord-252528-rgnhfcbx	165	62	missed	miss	VBN
cord-252528-rgnhfcbx	165	63	,	,	,
cord-252528-rgnhfcbx	165	64	can	can	MD
cord-252528-rgnhfcbx	165	65	benefit	benefit	VB
cord-252528-rgnhfcbx	165	66	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	165	67	patients	patient	NNS
cord-252528-rgnhfcbx	165	68	by	by	IN
cord-252528-rgnhfcbx	165	69	alleviating	alleviate	VBG
cord-252528-rgnhfcbx	165	70	tissue	tissue	NN
cord-252528-rgnhfcbx	165	71	damages	damage	NNS
cord-252528-rgnhfcbx	165	72	due	due	IN
cord-252528-rgnhfcbx	165	73	to	to	IN
cord-252528-rgnhfcbx	165	74	the	the	DT
cord-252528-rgnhfcbx	165	75	excessively	excessively	RB
cord-252528-rgnhfcbx	165	76	activated	activate	VBN
cord-252528-rgnhfcbx	165	77	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	165	78	response	response	NN
cord-252528-rgnhfcbx	165	79	[	[	-LRB-
cord-252528-rgnhfcbx	165	80	64	64	CD
cord-252528-rgnhfcbx	165	81	]	]	-RRB-
cord-252528-rgnhfcbx	165	82	.	.	.
cord-252528-rgnhfcbx	166	1	The	the	DT
cord-252528-rgnhfcbx	166	2	use	use	NN
cord-252528-rgnhfcbx	166	3	of	of	IN
cord-252528-rgnhfcbx	166	4	anti	anti	JJ
cord-252528-rgnhfcbx	166	5	-	-	JJ
cord-252528-rgnhfcbx	166	6	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	166	7	medications	medication	NNS
cord-252528-rgnhfcbx	166	8	,	,	,
cord-252528-rgnhfcbx	166	9	including	include	VBG
cord-252528-rgnhfcbx	166	10	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	166	11	,	,	,
cord-252528-rgnhfcbx	166	12	as	as	RB
cord-252528-rgnhfcbx	166	13	well	well	RB
cord-252528-rgnhfcbx	166	14	as	as	IN
cord-252528-rgnhfcbx	166	15	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	166	16	and	and	CC
cord-252528-rgnhfcbx	166	17	hydroxycloroquine	hydroxycloroquine	NN
cord-252528-rgnhfcbx	166	18	,	,	,
cord-252528-rgnhfcbx	166	19	to	to	TO
cord-252528-rgnhfcbx	166	20	suppress	suppress	VB
cord-252528-rgnhfcbx	166	21	the	the	DT
cord-252528-rgnhfcbx	166	22	over	over	RB
cord-252528-rgnhfcbx	166	23	-	-	HYPH
cord-252528-rgnhfcbx	166	24	activated	activate	VBN
cord-252528-rgnhfcbx	166	25	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	166	26	response	response	NN
cord-252528-rgnhfcbx	166	27	in	in	IN
cord-252528-rgnhfcbx	166	28	severe	severe	JJ
cord-252528-rgnhfcbx	166	29	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	166	30	has	have	VBZ
cord-252528-rgnhfcbx	166	31	been	be	VBN
cord-252528-rgnhfcbx	166	32	undergoing	undergo	VBG
cord-252528-rgnhfcbx	166	33	clinical	clinical	JJ
cord-252528-rgnhfcbx	166	34	investigations	investigation	NNS
cord-252528-rgnhfcbx	166	35	.	.	.
cord-252528-rgnhfcbx	167	1	By	by	IN
cord-252528-rgnhfcbx	167	2	antagonizing	antagonize	VBG
cord-252528-rgnhfcbx	167	3	the	the	DT
cord-252528-rgnhfcbx	167	4	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	167	5	with	with	IN
cord-252528-rgnhfcbx	167	6	pro	pro	JJ
cord-252528-rgnhfcbx	167	7	-	-	JJ
cord-252528-rgnhfcbx	167	8	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	167	9	effects	effect	NNS
cord-252528-rgnhfcbx	167	10	,	,	,
cord-252528-rgnhfcbx	167	11	these	these	DT
cord-252528-rgnhfcbx	167	12	anti	anti	JJ
cord-252528-rgnhfcbx	167	13	-	-	JJ
cord-252528-rgnhfcbx	167	14	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	167	15	medications	medication	NNS
cord-252528-rgnhfcbx	167	16	also	also	RB
cord-252528-rgnhfcbx	167	17	have	have	VBP
cord-252528-rgnhfcbx	167	18	the	the	DT
cord-252528-rgnhfcbx	167	19	potential	potential	NN
cord-252528-rgnhfcbx	167	20	to	to	TO
cord-252528-rgnhfcbx	167	21	lower	lower	VB
cord-252528-rgnhfcbx	167	22	the	the	DT
cord-252528-rgnhfcbx	167	23	risk	risk	NN
cord-252528-rgnhfcbx	167	24	of	of	IN
cord-252528-rgnhfcbx	167	25	vascular	vascular	JJ
cord-252528-rgnhfcbx	167	26	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	167	27	.	.	.
cord-252528-rgnhfcbx	168	1	Conventionally	conventionally	RB
cord-252528-rgnhfcbx	168	2	,	,	,
cord-252528-rgnhfcbx	168	3	corticosteroids	corticosteroid	NNS
cord-252528-rgnhfcbx	168	4	are	be	VBP
cord-252528-rgnhfcbx	168	5	used	use	VBN
cord-252528-rgnhfcbx	168	6	as	as	IN
cord-252528-rgnhfcbx	168	7	a	a	DT
cord-252528-rgnhfcbx	168	8	treatment	treatment	NN
cord-252528-rgnhfcbx	168	9	for	for	IN
cord-252528-rgnhfcbx	168	10	excessive	excessive	JJ
cord-252528-rgnhfcbx	168	11	inflammation	inflammation	NN
cord-252528-rgnhfcbx	168	12	,	,	,
cord-252528-rgnhfcbx	168	13	but	but	CC
cord-252528-rgnhfcbx	168	14	high	high	JJ
cord-252528-rgnhfcbx	168	15	doses	dose	NNS
cord-252528-rgnhfcbx	168	16	and	and	CC
cord-252528-rgnhfcbx	168	17	long	long	JJ
cord-252528-rgnhfcbx	168	18	durations	duration	NNS
cord-252528-rgnhfcbx	168	19	of	of	IN
cord-252528-rgnhfcbx	168	20	drug	drug	NN
cord-252528-rgnhfcbx	168	21	intake	intake	NN
cord-252528-rgnhfcbx	168	22	are	be	VBP
cord-252528-rgnhfcbx	168	23	often	often	RB
cord-252528-rgnhfcbx	168	24	needed	need	VBN
cord-252528-rgnhfcbx	168	25	,	,	,
cord-252528-rgnhfcbx	168	26	usually	usually	RB
cord-252528-rgnhfcbx	168	27	leading	lead	VBG
cord-252528-rgnhfcbx	168	28	to	to	IN
cord-252528-rgnhfcbx	168	29	serious	serious	JJ
cord-252528-rgnhfcbx	168	30	side	side	NN
cord-252528-rgnhfcbx	168	31	effects	effect	NNS
cord-252528-rgnhfcbx	168	32	[	[	-LRB-
cord-252528-rgnhfcbx	168	33	65	65	CD
cord-252528-rgnhfcbx	168	34	,	,	,
cord-252528-rgnhfcbx	168	35	66	66	CD
cord-252528-rgnhfcbx	168	36	]	]	-RRB-
cord-252528-rgnhfcbx	168	37	.	.	.
cord-252528-rgnhfcbx	169	1	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	169	2	is	be	VBZ
cord-252528-rgnhfcbx	169	3	considered	consider	VBN
cord-252528-rgnhfcbx	169	4	as	as	IN
cord-252528-rgnhfcbx	169	5	a	a	DT
cord-252528-rgnhfcbx	169	6	key	key	JJ
cord-252528-rgnhfcbx	169	7	mediator	mediator	NN
cord-252528-rgnhfcbx	169	8	of	of	IN
cord-252528-rgnhfcbx	169	9	excessive	excessive	JJ
cord-252528-rgnhfcbx	169	10	pro	pro	JJ
cord-252528-rgnhfcbx	169	11	-	-	JJ
cord-252528-rgnhfcbx	169	12	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	169	13	cytokine	cytokine	NN
cord-252528-rgnhfcbx	169	14	release	release	NN
cord-252528-rgnhfcbx	169	15	in	in	IN
cord-252528-rgnhfcbx	169	16	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	169	17	,	,	,
cord-252528-rgnhfcbx	169	18	and	and	CC
cord-252528-rgnhfcbx	169	19	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	169	20	,	,	,
cord-252528-rgnhfcbx	169	21	an	an	DT
cord-252528-rgnhfcbx	169	22	anti	anti	JJ
cord-252528-rgnhfcbx	169	23	-	-	JJ
cord-252528-rgnhfcbx	169	24	IL-6	il-6	JJ
cord-252528-rgnhfcbx	169	25	receptor	receptor	NN
cord-252528-rgnhfcbx	169	26	monoclonal	monoclonal	JJ
cord-252528-rgnhfcbx	169	27	antibody	antibody	NN
cord-252528-rgnhfcbx	169	28	,	,	,
cord-252528-rgnhfcbx	169	29	is	be	VBZ
cord-252528-rgnhfcbx	169	30	used	use	VBN
cord-252528-rgnhfcbx	169	31	to	to	TO
cord-252528-rgnhfcbx	169	32	suppress	suppress	VB
cord-252528-rgnhfcbx	169	33	the	the	DT
cord-252528-rgnhfcbx	169	34	over	over	RB
cord-252528-rgnhfcbx	169	35	-	-	HYPH
cord-252528-rgnhfcbx	169	36	activated	activate	VBN
cord-252528-rgnhfcbx	169	37	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	169	38	response	response	NN
cord-252528-rgnhfcbx	169	39	in	in	IN
cord-252528-rgnhfcbx	169	40	severe	severe	JJ
cord-252528-rgnhfcbx	169	41	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	169	42	cases	case	NNS
cord-252528-rgnhfcbx	169	43	in	in	IN
cord-252528-rgnhfcbx	169	44	several	several	JJ
cord-252528-rgnhfcbx	169	45	recent	recent	JJ
cord-252528-rgnhfcbx	169	46	observational	observational	JJ
cord-252528-rgnhfcbx	169	47	clinical	clinical	JJ
cord-252528-rgnhfcbx	169	48	studies	study	NNS
cord-252528-rgnhfcbx	169	49	.	.	.
cord-252528-rgnhfcbx	170	1	These	these	DT
cord-252528-rgnhfcbx	170	2	studies	study	NNS
cord-252528-rgnhfcbx	170	3	indicate	indicate	VBP
cord-252528-rgnhfcbx	170	4	that	that	IN
cord-252528-rgnhfcbx	170	5	tocilizumab	tocilizumab	NN
cord-252528-rgnhfcbx	170	6	,	,	,
cord-252528-rgnhfcbx	170	7	without	without	IN
cord-252528-rgnhfcbx	170	8	significant	significant	JJ
cord-252528-rgnhfcbx	170	9	associated	associate	VBD
cord-252528-rgnhfcbx	170	10	adverse	adverse	JJ
cord-252528-rgnhfcbx	170	11	effect	effect	NN
cord-252528-rgnhfcbx	170	12	,	,	,
cord-252528-rgnhfcbx	170	13	is	be	VBZ
cord-252528-rgnhfcbx	170	14	effective	effective	JJ
cord-252528-rgnhfcbx	170	15	for	for	IN
cord-252528-rgnhfcbx	170	16	controlling	control	VBG
cord-252528-rgnhfcbx	170	17	excessive	excessive	JJ
cord-252528-rgnhfcbx	170	18	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	170	19	and	and	CC
cord-252528-rgnhfcbx	170	20	reducing	reduce	VBG
cord-252528-rgnhfcbx	170	21	disease	disease	NN
cord-252528-rgnhfcbx	170	22	mortality	mortality	NN
cord-252528-rgnhfcbx	170	23	in	in	IN
cord-252528-rgnhfcbx	170	24	severe	severe	JJ
cord-252528-rgnhfcbx	170	25	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	170	26	patients	patient	NNS
cord-252528-rgnhfcbx	170	27	,	,	,
cord-252528-rgnhfcbx	170	28	especially	especially	RB
cord-252528-rgnhfcbx	170	29	for	for	IN
cord-252528-rgnhfcbx	170	30	those	those	DT
cord-252528-rgnhfcbx	170	31	with	with	IN
cord-252528-rgnhfcbx	170	32	significant	significant	JJ
cord-252528-rgnhfcbx	170	33	elevation	elevation	NN
cord-252528-rgnhfcbx	170	34	in	in	IN
cord-252528-rgnhfcbx	170	35	serum	serum	NN
cord-252528-rgnhfcbx	170	36	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	170	37	level	level	NN
cord-252528-rgnhfcbx	170	38	[	[	-LRB-
cord-252528-rgnhfcbx	170	39	66	66	CD
cord-252528-rgnhfcbx	170	40	,	,	,
cord-252528-rgnhfcbx	170	41	67	67	CD
cord-252528-rgnhfcbx	170	42	]	]	-RRB-
cord-252528-rgnhfcbx	170	43	.	.	.
cord-252528-rgnhfcbx	171	1	Besides	besides	RB
cord-252528-rgnhfcbx	171	2	,	,	,
cord-252528-rgnhfcbx	171	3	a	a	DT
cord-252528-rgnhfcbx	171	4	systemic	systemic	JJ
cord-252528-rgnhfcbx	171	5	review	review	NN
cord-252528-rgnhfcbx	171	6	also	also	RB
cord-252528-rgnhfcbx	171	7	indicates	indicate	VBZ
cord-252528-rgnhfcbx	171	8	that	that	IN
cord-252528-rgnhfcbx	171	9	tocilizumab	tocilizumab	NN
cord-252528-rgnhfcbx	171	10	could	could	MD
cord-252528-rgnhfcbx	171	11	be	be	VB
cord-252528-rgnhfcbx	171	12	a	a	DT
cord-252528-rgnhfcbx	171	13	promising	promising	JJ
cord-252528-rgnhfcbx	171	14	treatment	treatment	NN
cord-252528-rgnhfcbx	171	15	for	for	IN
cord-252528-rgnhfcbx	171	16	the	the	DT
cord-252528-rgnhfcbx	171	17	excessive	excessive	JJ
cord-252528-rgnhfcbx	171	18	inflammation	inflammation	NN
cord-252528-rgnhfcbx	171	19	in	in	IN
cord-252528-rgnhfcbx	171	20	severe	severe	JJ
cord-252528-rgnhfcbx	171	21	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	171	22	[	[	-LRB-
cord-252528-rgnhfcbx	171	23	68	68	CD
cord-252528-rgnhfcbx	171	24	]	]	-RRB-
cord-252528-rgnhfcbx	171	25	.	.	.
cord-252528-rgnhfcbx	172	1	However	however	RB
cord-252528-rgnhfcbx	172	2	,	,	,
cord-252528-rgnhfcbx	172	3	considering	consider	VBG
cord-252528-rgnhfcbx	172	4	the	the	DT
cord-252528-rgnhfcbx	172	5	number	number	NN
cord-252528-rgnhfcbx	172	6	of	of	IN
cord-252528-rgnhfcbx	172	7	patients	patient	NNS
cord-252528-rgnhfcbx	172	8	participated	participate	VBN
cord-252528-rgnhfcbx	172	9	in	in	IN
cord-252528-rgnhfcbx	172	10	these	these	DT
cord-252528-rgnhfcbx	172	11	studies	study	NNS
cord-252528-rgnhfcbx	172	12	are	be	VBP
cord-252528-rgnhfcbx	172	13	relatively	relatively	RB
cord-252528-rgnhfcbx	172	14	small	small	JJ
cord-252528-rgnhfcbx	172	15	,	,	,
cord-252528-rgnhfcbx	172	16	and	and	CC
cord-252528-rgnhfcbx	172	17	these	these	DT
cord-252528-rgnhfcbx	172	18	studies	study	NNS
cord-252528-rgnhfcbx	172	19	are	be	VBP
cord-252528-rgnhfcbx	172	20	merely	merely	RB
cord-252528-rgnhfcbx	172	21	observational	observational	JJ
cord-252528-rgnhfcbx	172	22	,	,	,
cord-252528-rgnhfcbx	172	23	the	the	DT
cord-252528-rgnhfcbx	172	24	conclusions	conclusion	NNS
cord-252528-rgnhfcbx	172	25	of	of	IN
cord-252528-rgnhfcbx	172	26	these	these	DT
cord-252528-rgnhfcbx	172	27	studies	study	NNS
cord-252528-rgnhfcbx	172	28	need	need	VBP
cord-252528-rgnhfcbx	172	29	to	to	TO
cord-252528-rgnhfcbx	172	30	be	be	VB
cord-252528-rgnhfcbx	172	31	confirmed	confirm	VBN
cord-252528-rgnhfcbx	172	32	by	by	IN
cord-252528-rgnhfcbx	172	33	randomized	randomized	JJ
cord-252528-rgnhfcbx	172	34	controlled	control	VBN
cord-252528-rgnhfcbx	172	35	clinical	clinical	JJ
cord-252528-rgnhfcbx	172	36	trials	trial	NNS
cord-252528-rgnhfcbx	172	37	with	with	IN
cord-252528-rgnhfcbx	172	38	larger	large	JJR
cord-252528-rgnhfcbx	172	39	numbers	number	NNS
cord-252528-rgnhfcbx	172	40	of	of	IN
cord-252528-rgnhfcbx	172	41	participants	participant	NNS
cord-252528-rgnhfcbx	172	42	.	.	.
cord-252528-rgnhfcbx	173	1	By	by	IN
cord-252528-rgnhfcbx	173	2	suppressing	suppress	VBG
cord-252528-rgnhfcbx	173	3	the	the	DT
cord-252528-rgnhfcbx	173	4	over	over	RB
cord-252528-rgnhfcbx	173	5	-	-	HYPH
cord-252528-rgnhfcbx	173	6	activated	activate	VBN
cord-252528-rgnhfcbx	173	7	inflammation	inflammation	NN
cord-252528-rgnhfcbx	173	8	,	,	,
cord-252528-rgnhfcbx	173	9	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	173	10	can	can	MD
cord-252528-rgnhfcbx	173	11	theoretically	theoretically	RB
cord-252528-rgnhfcbx	173	12	mitigate	mitigate	VB
cord-252528-rgnhfcbx	173	13	vascular	vascular	JJ
cord-252528-rgnhfcbx	173	14	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	173	15	by	by	IN
cord-252528-rgnhfcbx	173	16	reducing	reduce	VBG
cord-252528-rgnhfcbx	173	17	the	the	DT
cord-252528-rgnhfcbx	173	18	pro	pro	JJ
cord-252528-rgnhfcbx	173	19	-	-	JJ
cord-252528-rgnhfcbx	173	20	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	173	21	effects	effect	NNS
cord-252528-rgnhfcbx	173	22	of	of	IN
cord-252528-rgnhfcbx	173	23	the	the	DT
cord-252528-rgnhfcbx	173	24	pro	pro	JJ
cord-252528-rgnhfcbx	173	25	-	-	JJ
cord-252528-rgnhfcbx	173	26	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	173	27	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	173	28	during	during	IN
cord-252528-rgnhfcbx	173	29	excessive	excessive	JJ
cord-252528-rgnhfcbx	173	30	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	173	31	in	in	IN
cord-252528-rgnhfcbx	173	32	severe	severe	JJ
cord-252528-rgnhfcbx	173	33	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	173	34	(	(	-LRB-
cord-252528-rgnhfcbx	173	35	Fig	Fig	NNP
cord-252528-rgnhfcbx	173	36	.	.	NNP
cord-252528-rgnhfcbx	173	37	2	2	CD
cord-252528-rgnhfcbx	173	38	)	)	-RRB-
cord-252528-rgnhfcbx	173	39	.	.	.
cord-252528-rgnhfcbx	174	1	Hence	hence	RB
cord-252528-rgnhfcbx	174	2	,	,	,
cord-252528-rgnhfcbx	174	3	future	future	JJ
cord-252528-rgnhfcbx	174	4	clinical	clinical	JJ
cord-252528-rgnhfcbx	174	5	studies	study	NNS
cord-252528-rgnhfcbx	174	6	of	of	IN
cord-252528-rgnhfcbx	174	7	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	174	8	could	could	MD
cord-252528-rgnhfcbx	174	9	evaluate	evaluate	VB
cord-252528-rgnhfcbx	174	10	the	the	DT
cord-252528-rgnhfcbx	174	11	potential	potential	NN
cord-252528-rgnhfcbx	174	12	of	of	IN
cord-252528-rgnhfcbx	174	13	tocilizumab	tocilizumab	NN
cord-252528-rgnhfcbx	174	14	to	to	TO
cord-252528-rgnhfcbx	174	15	reduce	reduce	VB
cord-252528-rgnhfcbx	174	16	vascular	vascular	JJ
cord-252528-rgnhfcbx	174	17	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	174	18	events	event	NNS
cord-252528-rgnhfcbx	174	19	by	by	IN
cord-252528-rgnhfcbx	174	20	adding	add	VBG
cord-252528-rgnhfcbx	174	21	vascular	vascular	JJ
cord-252528-rgnhfcbx	174	22	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	174	23	complications	complication	NNS
cord-252528-rgnhfcbx	174	24	,	,	,
cord-252528-rgnhfcbx	174	25	including	include	VBG
cord-252528-rgnhfcbx	174	26	DIC	DIC	NNP
cord-252528-rgnhfcbx	174	27	,	,	,
cord-252528-rgnhfcbx	174	28	as	as	IN
cord-252528-rgnhfcbx	174	29	a	a	DT
cord-252528-rgnhfcbx	174	30	secondary	secondary	JJ
cord-252528-rgnhfcbx	174	31	endpoint	endpoint	NN
cord-252528-rgnhfcbx	174	32	.	.	.
cord-252528-rgnhfcbx	175	1	According	accord	VBG
cord-252528-rgnhfcbx	175	2	to	to	IN
cord-252528-rgnhfcbx	175	3	recent	recent	JJ
cord-252528-rgnhfcbx	175	4	clinical	clinical	JJ
cord-252528-rgnhfcbx	175	5	studies	study	NNS
cord-252528-rgnhfcbx	175	6	,	,	,
cord-252528-rgnhfcbx	175	7	low	low	JJ
cord-252528-rgnhfcbx	175	8	dosage	dosage	NN
cord-252528-rgnhfcbx	175	9	of	of	IN
cord-252528-rgnhfcbx	175	10	adjunctive	adjunctive	JJ
cord-252528-rgnhfcbx	175	11	chloroquine	chloroquine	NNP
cord-252528-rgnhfcbx	175	12	and	and	CC
cord-252528-rgnhfcbx	175	13	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	175	14	treatment	treatment	NN
cord-252528-rgnhfcbx	175	15	could	could	MD
cord-252528-rgnhfcbx	175	16	be	be	VB
cord-252528-rgnhfcbx	175	17	an	an	DT
cord-252528-rgnhfcbx	175	18	effective	effective	JJ
cord-252528-rgnhfcbx	175	19	solution	solution	NN
cord-252528-rgnhfcbx	175	20	for	for	IN
cord-252528-rgnhfcbx	175	21	excessive	excessive	JJ
cord-252528-rgnhfcbx	175	22	pro	pro	JJ
cord-252528-rgnhfcbx	175	23	-	-	JJ
cord-252528-rgnhfcbx	175	24	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	175	25	cytokine	cytokine	NN
cord-252528-rgnhfcbx	175	26	release	release	NN
cord-252528-rgnhfcbx	175	27	in	in	IN
cord-252528-rgnhfcbx	175	28	severe	severe	JJ
cord-252528-rgnhfcbx	175	29	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	175	30	patients	patient	NNS
cord-252528-rgnhfcbx	175	31	.	.	.
cord-252528-rgnhfcbx	176	1	In	in	IN
cord-252528-rgnhfcbx	176	2	a	a	DT
cord-252528-rgnhfcbx	176	3	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	176	4	observational	observational	JJ
cord-252528-rgnhfcbx	176	5	study	study	NN
cord-252528-rgnhfcbx	176	6	with	with	IN
cord-252528-rgnhfcbx	176	7	550	550	CD
cord-252528-rgnhfcbx	176	8	patients	patient	NNS
cord-252528-rgnhfcbx	176	9	,	,	,
cord-252528-rgnhfcbx	176	10	in	in	IN
cord-252528-rgnhfcbx	176	11	addition	addition	NN
cord-252528-rgnhfcbx	176	12	to	to	IN
cord-252528-rgnhfcbx	176	13	the	the	DT
cord-252528-rgnhfcbx	176	14	basic	basic	JJ
cord-252528-rgnhfcbx	176	15	treatments	treatment	NNS
cord-252528-rgnhfcbx	176	16	for	for	IN
cord-252528-rgnhfcbx	176	17	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	176	18	,	,	,
cord-252528-rgnhfcbx	176	19	low	low	JJ
cord-252528-rgnhfcbx	176	20	doses	dose	NNS
cord-252528-rgnhfcbx	176	21	of	of	IN
cord-252528-rgnhfcbx	176	22	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	176	23	significantly	significantly	RB
cord-252528-rgnhfcbx	176	24	reduce	reduce	VB
cord-252528-rgnhfcbx	176	25	the	the	DT
cord-252528-rgnhfcbx	176	26	fatality	fatality	NN
cord-252528-rgnhfcbx	176	27	and	and	CC
cord-252528-rgnhfcbx	176	28	the	the	DT
cord-252528-rgnhfcbx	176	29	serum	serum	NN
cord-252528-rgnhfcbx	176	30	level	level	NN
cord-252528-rgnhfcbx	176	31	of	of	IN
cord-252528-rgnhfcbx	176	32	pro	pro	JJ
cord-252528-rgnhfcbx	176	33	-	-	JJ
cord-252528-rgnhfcbx	176	34	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	176	35	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	176	36	in	in	IN
cord-252528-rgnhfcbx	176	37	severe	severe	JJ
cord-252528-rgnhfcbx	176	38	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	176	39	patients	patient	NNS
cord-252528-rgnhfcbx	176	40	[	[	-LRB-
cord-252528-rgnhfcbx	176	41	69	69	CD
cord-252528-rgnhfcbx	176	42	]	]	-RRB-
cord-252528-rgnhfcbx	176	43	.	.	.
cord-252528-rgnhfcbx	177	1	A	a	DT
cord-252528-rgnhfcbx	177	2	randomized	randomized	JJ
cord-252528-rgnhfcbx	177	3	controlled	control	VBN
cord-252528-rgnhfcbx	177	4	clinical	clinical	JJ
cord-252528-rgnhfcbx	177	5	trial	trial	NN
cord-252528-rgnhfcbx	177	6	suggests	suggest	VBZ
cord-252528-rgnhfcbx	177	7	that	that	IN
cord-252528-rgnhfcbx	177	8	compared	compare	VBN
cord-252528-rgnhfcbx	177	9	to	to	IN
cord-252528-rgnhfcbx	177	10	a	a	DT
cord-252528-rgnhfcbx	177	11	low	low	JJ
cord-252528-rgnhfcbx	177	12	dosage	dosage	NN
cord-252528-rgnhfcbx	177	13	of	of	IN
cord-252528-rgnhfcbx	177	14	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	177	15	treatment	treatment	NN
cord-252528-rgnhfcbx	177	16	,	,	,
cord-252528-rgnhfcbx	177	17	a	a	DT
cord-252528-rgnhfcbx	177	18	high	high	JJ
cord-252528-rgnhfcbx	177	19	dosage	dosage	NN
cord-252528-rgnhfcbx	177	20	of	of	IN
cord-252528-rgnhfcbx	177	21	chloroquine	chloroquine	JJ
cord-252528-rgnhfcbx	177	22	treatment	treatment	NN
cord-252528-rgnhfcbx	177	23	for	for	IN
cord-252528-rgnhfcbx	177	24	severe	severe	JJ
cord-252528-rgnhfcbx	177	25	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	177	26	patients	patient	NNS
cord-252528-rgnhfcbx	177	27	is	be	VBZ
cord-252528-rgnhfcbx	177	28	associated	associate	VBN
cord-252528-rgnhfcbx	177	29	with	with	IN
cord-252528-rgnhfcbx	177	30	increased	increase	VBN
cord-252528-rgnhfcbx	177	31	incidences	incidence	NNS
cord-252528-rgnhfcbx	177	32	of	of	IN
cord-252528-rgnhfcbx	177	33	adverse	adverse	JJ
cord-252528-rgnhfcbx	177	34	effects	effect	NNS
cord-252528-rgnhfcbx	177	35	,	,	,
cord-252528-rgnhfcbx	177	36	especially	especially	RB
cord-252528-rgnhfcbx	177	37	when	when	WRB
cord-252528-rgnhfcbx	177	38	used	use	VBN
cord-252528-rgnhfcbx	177	39	adjunctively	adjunctively	RB
cord-252528-rgnhfcbx	177	40	with	with	IN
cord-252528-rgnhfcbx	177	41	other	other	JJ
cord-252528-rgnhfcbx	177	42	antibiotics	antibiotic	NNS
cord-252528-rgnhfcbx	177	43	or	or	CC
cord-252528-rgnhfcbx	177	44	anti	anti	JJ
cord-252528-rgnhfcbx	177	45	-	-	JJ
cord-252528-rgnhfcbx	177	46	viral	viral	JJ
cord-252528-rgnhfcbx	177	47	medications	medication	NNS
cord-252528-rgnhfcbx	177	48	[	[	-LRB-
cord-252528-rgnhfcbx	177	49	70	70	CD
cord-252528-rgnhfcbx	177	50	]	]	-RRB-
cord-252528-rgnhfcbx	177	51	.	.	.
cord-252528-rgnhfcbx	178	1	However	however	RB
cord-252528-rgnhfcbx	178	2	,	,	,
cord-252528-rgnhfcbx	178	3	severe	severe	JJ
cord-252528-rgnhfcbx	178	4	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	178	5	patients	patient	NNS
cord-252528-rgnhfcbx	178	6	in	in	IN
cord-252528-rgnhfcbx	178	7	the	the	DT
cord-252528-rgnhfcbx	178	8	group	group	NN
cord-252528-rgnhfcbx	178	9	receiving	receive	VBG
cord-252528-rgnhfcbx	178	10	high	high	JJ
cord-252528-rgnhfcbx	178	11	dosage	dosage	NN
cord-252528-rgnhfcbx	178	12	of	of	IN
cord-252528-rgnhfcbx	178	13	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	178	14	treatment	treatment	NN
cord-252528-rgnhfcbx	178	15	are	be	VBP
cord-252528-rgnhfcbx	178	16	of	of	IN
cord-252528-rgnhfcbx	178	17	older	old	JJR
cord-252528-rgnhfcbx	178	18	ages	age	NNS
cord-252528-rgnhfcbx	178	19	,	,	,
cord-252528-rgnhfcbx	178	20	which	which	WDT
cord-252528-rgnhfcbx	178	21	could	could	MD
cord-252528-rgnhfcbx	178	22	be	be	VB
cord-252528-rgnhfcbx	178	23	a	a	DT
cord-252528-rgnhfcbx	178	24	confounding	confounding	JJ
cord-252528-rgnhfcbx	178	25	factor	factor	NN
cord-252528-rgnhfcbx	178	26	in	in	IN
cord-252528-rgnhfcbx	178	27	this	this	DT
cord-252528-rgnhfcbx	178	28	randomized	randomized	JJ
cord-252528-rgnhfcbx	178	29	clinical	clinical	JJ
cord-252528-rgnhfcbx	178	30	trial	trial	NN
cord-252528-rgnhfcbx	178	31	.	.	.
cord-252528-rgnhfcbx	179	1	Chloroquine	Chloroquine	NNP
cord-252528-rgnhfcbx	179	2	and	and	CC
cord-252528-rgnhfcbx	179	3	hydroxychloroquine	hydroxychloroquine	NNP
cord-252528-rgnhfcbx	179	4	,	,	,
cord-252528-rgnhfcbx	179	5	which	which	WDT
cord-252528-rgnhfcbx	179	6	can	can	MD
cord-252528-rgnhfcbx	179	7	be	be	VB
cord-252528-rgnhfcbx	179	8	promising	promise	VBG
cord-252528-rgnhfcbx	179	9	in	in	IN
cord-252528-rgnhfcbx	179	10	the	the	DT
cord-252528-rgnhfcbx	179	11	treatment	treatment	NN
cord-252528-rgnhfcbx	179	12	of	of	IN
cord-252528-rgnhfcbx	179	13	excessive	excessive	JJ
cord-252528-rgnhfcbx	179	14	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	179	15	response	response	NN
cord-252528-rgnhfcbx	179	16	in	in	IN
cord-252528-rgnhfcbx	179	17	severe	severe	JJ
cord-252528-rgnhfcbx	179	18	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	179	19	,	,	,
cord-252528-rgnhfcbx	179	20	have	have	VBP
cord-252528-rgnhfcbx	179	21	both	both	DT
cord-252528-rgnhfcbx	179	22	immuno	immuno	JJ
cord-252528-rgnhfcbx	179	23	-	-	HYPH
cord-252528-rgnhfcbx	179	24	modulatory	modulatory	JJ
cord-252528-rgnhfcbx	179	25	and	and	CC
cord-252528-rgnhfcbx	179	26	anti	anti	JJ
cord-252528-rgnhfcbx	179	27	-	-	JJ
cord-252528-rgnhfcbx	179	28	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	179	29	functions	function	NNS
cord-252528-rgnhfcbx	179	30	.	.	.
cord-252528-rgnhfcbx	180	1	Chloroquine	Chloroquine	NNP
cord-252528-rgnhfcbx	180	2	and	and	CC
cord-252528-rgnhfcbx	180	3	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	180	4	can	can	MD
cord-252528-rgnhfcbx	180	5	inhibit	inhibit	VB
cord-252528-rgnhfcbx	180	6	the	the	DT
cord-252528-rgnhfcbx	180	7	production	production	NN
cord-252528-rgnhfcbx	180	8	of	of	IN
cord-252528-rgnhfcbx	180	9	IFN	IFN	NNP
cord-252528-rgnhfcbx	180	10	-	-	HYPH
cord-252528-rgnhfcbx	180	11	γ	γ	NNP
cord-252528-rgnhfcbx	180	12	,	,	,
cord-252528-rgnhfcbx	180	13	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	180	14	,	,	,
cord-252528-rgnhfcbx	180	15	and	and	CC
cord-252528-rgnhfcbx	180	16	TNF	TNF	NNP
cord-252528-rgnhfcbx	180	17	-	-	HYPH
cord-252528-rgnhfcbx	180	18	α	α	NN
cord-252528-rgnhfcbx	180	19	by	by	IN
cord-252528-rgnhfcbx	180	20	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	180	21	blood	blood	NN
cord-252528-rgnhfcbx	180	22	mononuclear	mononuclear	NN
cord-252528-rgnhfcbx	180	23	cells	cell	NNS
cord-252528-rgnhfcbx	180	24	(	(	-LRB-
cord-252528-rgnhfcbx	180	25	PBMCs	pbmc	NNS
cord-252528-rgnhfcbx	180	26	)	)	-RRB-
cord-252528-rgnhfcbx	180	27	[	[	-LRB-
cord-252528-rgnhfcbx	180	28	71	71	CD
cord-252528-rgnhfcbx	180	29	]	]	-RRB-
cord-252528-rgnhfcbx	180	30	.	.	.
cord-252528-rgnhfcbx	181	1	This	this	DT
cord-252528-rgnhfcbx	181	2	modulation	modulation	NN
cord-252528-rgnhfcbx	181	3	in	in	IN
cord-252528-rgnhfcbx	181	4	immunological	immunological	JJ
cord-252528-rgnhfcbx	181	5	activities	activity	NNS
cord-252528-rgnhfcbx	181	6	of	of	IN
cord-252528-rgnhfcbx	181	7	PBMCs	pbmc	NNS
cord-252528-rgnhfcbx	181	8	is	be	VBZ
cord-252528-rgnhfcbx	181	9	critical	critical	JJ
cord-252528-rgnhfcbx	181	10	in	in	IN
cord-252528-rgnhfcbx	181	11	preventing	prevent	VBG
cord-252528-rgnhfcbx	181	12	the	the	DT
cord-252528-rgnhfcbx	181	13	viscious	viscious	JJ
cord-252528-rgnhfcbx	181	14	cycle	cycle	NN
cord-252528-rgnhfcbx	181	15	of	of	IN
cord-252528-rgnhfcbx	181	16	excessive	excessive	JJ
cord-252528-rgnhfcbx	181	17	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	181	18	in	in	IN
cord-252528-rgnhfcbx	181	19	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	181	20	(	(	-LRB-
cord-252528-rgnhfcbx	181	21	Fig	Fig	NNP
cord-252528-rgnhfcbx	181	22	.	.	.
cord-252528-rgnhfcbx	181	23	1	1	CD
cord-252528-rgnhfcbx	181	24	)	)	-RRB-
cord-252528-rgnhfcbx	181	25	,	,	,
cord-252528-rgnhfcbx	181	26	hence	hence	RB
cord-252528-rgnhfcbx	181	27	,	,	,
cord-252528-rgnhfcbx	181	28	reducing	reduce	VBG
cord-252528-rgnhfcbx	181	29	the	the	DT
cord-252528-rgnhfcbx	181	30	risk	risk	NN
cord-252528-rgnhfcbx	181	31	of	of	IN
cord-252528-rgnhfcbx	181	32	excessive	excessive	JJ
cord-252528-rgnhfcbx	181	33	pro	pro	JJ
cord-252528-rgnhfcbx	181	34	-	-	JJ
cord-252528-rgnhfcbx	181	35	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	181	36	cytokine	cytokine	NN
cord-252528-rgnhfcbx	181	37	release	release	NN
cord-252528-rgnhfcbx	181	38	and	and	CC
cord-252528-rgnhfcbx	181	39	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	181	40	state	state	NN
cord-252528-rgnhfcbx	182	1	(	(	-LRB-
cord-252528-rgnhfcbx	182	2	Fig	Fig	NNP
cord-252528-rgnhfcbx	182	3	.	.	NNP
cord-252528-rgnhfcbx	182	4	2	2	CD
cord-252528-rgnhfcbx	182	5	)	)	-RRB-
cord-252528-rgnhfcbx	182	6	.	.	.
cord-252528-rgnhfcbx	183	1	Despite	despite	IN
cord-252528-rgnhfcbx	183	2	the	the	DT
cord-252528-rgnhfcbx	183	3	negative	negative	JJ
cord-252528-rgnhfcbx	183	4	regulating	regulate	VBG
cord-252528-rgnhfcbx	183	5	effects	effect	NNS
cord-252528-rgnhfcbx	183	6	on	on	IN
cord-252528-rgnhfcbx	183	7	pro	pro	JJ
cord-252528-rgnhfcbx	183	8	-	-	JJ
cord-252528-rgnhfcbx	183	9	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	183	10	cytokine	cytokine	NN
cord-252528-rgnhfcbx	183	11	productions	production	NNS
cord-252528-rgnhfcbx	183	12	,	,	,
cord-252528-rgnhfcbx	183	13	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	183	14	and	and	CC
cord-252528-rgnhfcbx	183	15	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	183	16	are	be	VBP
cord-252528-rgnhfcbx	183	17	less	less	RBR
cord-252528-rgnhfcbx	183	18	associated	associate	VBN
cord-252528-rgnhfcbx	183	19	with	with	IN
cord-252528-rgnhfcbx	183	20	secondary	secondary	JJ
cord-252528-rgnhfcbx	183	21	infections	infection	NNS
cord-252528-rgnhfcbx	183	22	following	follow	VBG
cord-252528-rgnhfcbx	183	23	their	-PRON-	PRP$
cord-252528-rgnhfcbx	183	24	treatment	treatment	NN
cord-252528-rgnhfcbx	183	25	than	than	IN
cord-252528-rgnhfcbx	183	26	immuno	immuno	JJ
cord-252528-rgnhfcbx	183	27	-	-	JJ
cord-252528-rgnhfcbx	183	28	suppressive	suppressive	JJ
cord-252528-rgnhfcbx	183	29	medications	medication	NNS
cord-252528-rgnhfcbx	183	30	are	be	VBP
cord-252528-rgnhfcbx	183	31	,	,	,
cord-252528-rgnhfcbx	183	32	as	as	IN
cord-252528-rgnhfcbx	183	33	their	-PRON-	PRP$
cord-252528-rgnhfcbx	183	34	effects	effect	NNS
cord-252528-rgnhfcbx	183	35	on	on	IN
cord-252528-rgnhfcbx	183	36	the	the	DT
cord-252528-rgnhfcbx	183	37	immune	immune	JJ
cord-252528-rgnhfcbx	183	38	system	system	NN
cord-252528-rgnhfcbx	183	39	is	be	VBZ
cord-252528-rgnhfcbx	183	40	immuno	immuno	JJ
cord-252528-rgnhfcbx	183	41	-	-	JJ
cord-252528-rgnhfcbx	183	42	modulatory	modulatory	JJ
cord-252528-rgnhfcbx	183	43	[	[	-LRB-
cord-252528-rgnhfcbx	183	44	72	72	CD
cord-252528-rgnhfcbx	183	45	]	]	-RRB-
cord-252528-rgnhfcbx	183	46	.	.	.
cord-252528-rgnhfcbx	184	1	In	in	IN
cord-252528-rgnhfcbx	184	2	addition	addition	NN
cord-252528-rgnhfcbx	184	3	,	,	,
cord-252528-rgnhfcbx	184	4	hydroxychloroquine	hydroxychloroquine	NNP
cord-252528-rgnhfcbx	184	5	reduces	reduce	VBZ
cord-252528-rgnhfcbx	184	6	the	the	DT
cord-252528-rgnhfcbx	184	7	risk	risk	NN
cord-252528-rgnhfcbx	184	8	of	of	IN
cord-252528-rgnhfcbx	184	9	vascular	vascular	JJ
cord-252528-rgnhfcbx	184	10	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	184	11	by	by	IN
cord-252528-rgnhfcbx	184	12	inhibiting	inhibit	VBG
cord-252528-rgnhfcbx	184	13	platelet	platelet	NN
cord-252528-rgnhfcbx	184	14	activation	activation	NN
cord-252528-rgnhfcbx	184	15	in	in	IN
cord-252528-rgnhfcbx	184	16	response	response	NN
cord-252528-rgnhfcbx	184	17	to	to	IN
cord-252528-rgnhfcbx	184	18	pro	pro	JJ
cord-252528-rgnhfcbx	184	19	-	-	JJ
cord-252528-rgnhfcbx	184	20	coagulant	coagulant	JJ
cord-252528-rgnhfcbx	184	21	factors	factor	NNS
cord-252528-rgnhfcbx	184	22	,	,	,
cord-252528-rgnhfcbx	184	23	as	as	IN
cord-252528-rgnhfcbx	184	24	evidenced	evidence	VBN
cord-252528-rgnhfcbx	184	25	by	by	IN
cord-252528-rgnhfcbx	184	26	the	the	DT
cord-252528-rgnhfcbx	184	27	in	in	FW
cord-252528-rgnhfcbx	184	28	vitro	vitro	FW
cord-252528-rgnhfcbx	184	29	study	study	NN
cord-252528-rgnhfcbx	184	30	showing	show	VBG
cord-252528-rgnhfcbx	184	31	that	that	IN
cord-252528-rgnhfcbx	184	32	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	184	33	,	,	,
cord-252528-rgnhfcbx	184	34	at	at	IN
cord-252528-rgnhfcbx	184	35	the	the	DT
cord-252528-rgnhfcbx	184	36	concentration	concentration	NN
cord-252528-rgnhfcbx	184	37	of	of	IN
cord-252528-rgnhfcbx	184	38	1	1	CD
cord-252528-rgnhfcbx	184	39	mM	mm	CD
cord-252528-rgnhfcbx	184	40	,	,	,
cord-252528-rgnhfcbx	184	41	abrogates	abrogate	VBZ
cord-252528-rgnhfcbx	184	42	expressions	expression	NNS
cord-252528-rgnhfcbx	184	43	of	of	IN
cord-252528-rgnhfcbx	184	44	platelet	platelet	NN
cord-252528-rgnhfcbx	184	45	CD41a	CD41a	NNP
cord-252528-rgnhfcbx	184	46	and	and	CC
cord-252528-rgnhfcbx	184	47	CD61	CD61	NNP
cord-252528-rgnhfcbx	184	48	,	,	,
cord-252528-rgnhfcbx	184	49	which	which	WDT
cord-252528-rgnhfcbx	184	50	indicate	indicate	VBP
cord-252528-rgnhfcbx	184	51	platelet	platelet	NN
cord-252528-rgnhfcbx	184	52	activation	activation	NN
cord-252528-rgnhfcbx	184	53	,	,	,
cord-252528-rgnhfcbx	184	54	following	follow	VBG
cord-252528-rgnhfcbx	184	55	aPL	apl	CD
cord-252528-rgnhfcbx	184	56	and	and	CC
cord-252528-rgnhfcbx	184	57	thrombin	thrombin	JJ
cord-252528-rgnhfcbx	184	58	agonist	agonist	NN
cord-252528-rgnhfcbx	184	59	receptor	receptor	NN
cord-252528-rgnhfcbx	184	60	peptide	peptide	NN
cord-252528-rgnhfcbx	184	61	treatment	treatment	NN
cord-252528-rgnhfcbx	184	62	.	.	.
cord-252528-rgnhfcbx	185	1	This	this	DT
cord-252528-rgnhfcbx	185	2	inhibitory	inhibitory	JJ
cord-252528-rgnhfcbx	185	3	effect	effect	NN
cord-252528-rgnhfcbx	185	4	of	of	IN
cord-252528-rgnhfcbx	185	5	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	185	6	on	on	IN
cord-252528-rgnhfcbx	185	7	platelet	platelet	NN
cord-252528-rgnhfcbx	185	8	activation	activation	NN
cord-252528-rgnhfcbx	185	9	is	be	VBZ
cord-252528-rgnhfcbx	185	10	also	also	RB
cord-252528-rgnhfcbx	185	11	present	present	JJ
cord-252528-rgnhfcbx	185	12	even	even	RB
cord-252528-rgnhfcbx	185	13	when	when	WRB
cord-252528-rgnhfcbx	185	14	the	the	DT
cord-252528-rgnhfcbx	185	15	concentration	concentration	NN
cord-252528-rgnhfcbx	185	16	of	of	IN
cord-252528-rgnhfcbx	185	17	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	185	18	is	be	VBZ
cord-252528-rgnhfcbx	185	19	as	as	RB
cord-252528-rgnhfcbx	185	20	low	low	JJ
cord-252528-rgnhfcbx	185	21	as	as	IN
cord-252528-rgnhfcbx	185	22	0.0125	0.0125	CD
cord-252528-rgnhfcbx	185	23	mM	mm	CD
cord-252528-rgnhfcbx	185	24	[	[	-LRB-
cord-252528-rgnhfcbx	185	25	73	73	CD
cord-252528-rgnhfcbx	185	26	]	]	-RRB-
cord-252528-rgnhfcbx	185	27	.	.	.
cord-252528-rgnhfcbx	186	1	Similar	similar	JJ
cord-252528-rgnhfcbx	186	2	function	function	NN
cord-252528-rgnhfcbx	186	3	in	in	IN
cord-252528-rgnhfcbx	186	4	the	the	DT
cord-252528-rgnhfcbx	186	5	inhibition	inhibition	NN
cord-252528-rgnhfcbx	186	6	of	of	IN
cord-252528-rgnhfcbx	186	7	platelet	platelet	NN
cord-252528-rgnhfcbx	186	8	activation	activation	NN
cord-252528-rgnhfcbx	186	9	has	have	VBZ
cord-252528-rgnhfcbx	186	10	also	also	RB
cord-252528-rgnhfcbx	186	11	been	be	VBN
cord-252528-rgnhfcbx	186	12	demonstrated	demonstrate	VBN
cord-252528-rgnhfcbx	186	13	in	in	IN
cord-252528-rgnhfcbx	186	14	vitro	vitro	FW
cord-252528-rgnhfcbx	186	15	with	with	IN
cord-252528-rgnhfcbx	186	16	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	186	17	[	[	-LRB-
cord-252528-rgnhfcbx	186	18	74	74	CD
cord-252528-rgnhfcbx	186	19	]	]	-RRB-
cord-252528-rgnhfcbx	186	20	.	.	.
cord-252528-rgnhfcbx	187	1	In	in	IN
cord-252528-rgnhfcbx	187	2	agreement	agreement	NN
cord-252528-rgnhfcbx	187	3	with	with	IN
cord-252528-rgnhfcbx	187	4	its	-PRON-	PRP$
cord-252528-rgnhfcbx	187	5	function	function	NN
cord-252528-rgnhfcbx	187	6	of	of	IN
cord-252528-rgnhfcbx	187	7	platelet	platelet	NN
cord-252528-rgnhfcbx	187	8	inhibition	inhibition	NN
cord-252528-rgnhfcbx	187	9	,	,	,
cord-252528-rgnhfcbx	187	10	hydroxychloroquine	hydroxychloroquine	NNP
cord-252528-rgnhfcbx	187	11	can	can	MD
cord-252528-rgnhfcbx	187	12	reduce	reduce	VB
cord-252528-rgnhfcbx	187	13	the	the	DT
cord-252528-rgnhfcbx	187	14	incidence	incidence	NN
cord-252528-rgnhfcbx	187	15	of	of	IN
cord-252528-rgnhfcbx	187	16	vascular	vascular	JJ
cord-252528-rgnhfcbx	187	17	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	187	18	events	event	NNS
cord-252528-rgnhfcbx	187	19	after	after	IN
cord-252528-rgnhfcbx	187	20	operations	operation	NNS
cord-252528-rgnhfcbx	187	21	or	or	CC
cord-252528-rgnhfcbx	187	22	in	in	IN
cord-252528-rgnhfcbx	187	23	autoimmune	autoimmune	JJ
cord-252528-rgnhfcbx	187	24	diseases	disease	NNS
cord-252528-rgnhfcbx	187	25	including	include	VBG
cord-252528-rgnhfcbx	187	26	systemic	systemic	JJ
cord-252528-rgnhfcbx	187	27	lupus	lupus	NN
cord-252528-rgnhfcbx	187	28	erythematosus	erythematosus	NN
cord-252528-rgnhfcbx	187	29	(	(	-LRB-
cord-252528-rgnhfcbx	187	30	SLE	SLE	NNP
cord-252528-rgnhfcbx	187	31	)	)	-RRB-
cord-252528-rgnhfcbx	187	32	and	and	CC
cord-252528-rgnhfcbx	187	33	APS	APS	NNP
cord-252528-rgnhfcbx	187	34	[	[	-LRB-
cord-252528-rgnhfcbx	187	35	75	75	CD
cord-252528-rgnhfcbx	187	36	,	,	,
cord-252528-rgnhfcbx	187	37	76	76	CD
cord-252528-rgnhfcbx	187	38	]	]	-RRB-
cord-252528-rgnhfcbx	187	39	.	.	.
cord-252528-rgnhfcbx	188	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	188	2	,	,	,
cord-252528-rgnhfcbx	188	3	In	in	IN
cord-252528-rgnhfcbx	188	4	vitro	vitro	FW
cord-252528-rgnhfcbx	188	5	evidence	evidence	NN
cord-252528-rgnhfcbx	188	6	has	have	VBZ
cord-252528-rgnhfcbx	188	7	shown	show	VBN
cord-252528-rgnhfcbx	188	8	that	that	IN
cord-252528-rgnhfcbx	188	9	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	188	10	prevents	prevent	VBZ
cord-252528-rgnhfcbx	188	11	SARS	SARS	NNP
cord-252528-rgnhfcbx	188	12	-	-	HYPH
cord-252528-rgnhfcbx	188	13	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	188	14	infection	infection	NN
cord-252528-rgnhfcbx	188	15	in	in	IN
cord-252528-rgnhfcbx	188	16	Vero	Vero	NNP
cord-252528-rgnhfcbx	188	17	E6	E6	NNP
cord-252528-rgnhfcbx	188	18	cells	cell	NNS
cord-252528-rgnhfcbx	188	19	by	by	IN
cord-252528-rgnhfcbx	188	20	preventing	prevent	VBG
cord-252528-rgnhfcbx	188	21	cell	cell	NN
cord-252528-rgnhfcbx	188	22	entry	entry	NN
cord-252528-rgnhfcbx	188	23	and	and	CC
cord-252528-rgnhfcbx	188	24	interfering	interfere	VBG
cord-252528-rgnhfcbx	188	25	with	with	IN
cord-252528-rgnhfcbx	188	26	the	the	DT
cord-252528-rgnhfcbx	188	27	process	process	NN
cord-252528-rgnhfcbx	188	28	of	of	IN
cord-252528-rgnhfcbx	188	29	virus	virus	NN
cord-252528-rgnhfcbx	188	30	-	-	HYPH
cord-252528-rgnhfcbx	188	31	cell	cell	NN
cord-252528-rgnhfcbx	188	32	fusion	fusion	NN
cord-252528-rgnhfcbx	188	33	[	[	-LRB-
cord-252528-rgnhfcbx	188	34	77	77	CD
cord-252528-rgnhfcbx	188	35	]	]	-RRB-
cord-252528-rgnhfcbx	188	36	.	.	.
cord-252528-rgnhfcbx	189	1	Chloroquine	Chloroquine	NNP
cord-252528-rgnhfcbx	189	2	can	can	MD
cord-252528-rgnhfcbx	189	3	interfere	interfere	VB
cord-252528-rgnhfcbx	189	4	with	with	IN
cord-252528-rgnhfcbx	189	5	host	host	NN
cord-252528-rgnhfcbx	189	6	cell	cell	NN
cord-252528-rgnhfcbx	189	7	-	-	HYPH
cord-252528-rgnhfcbx	189	8	entry	entry	NN
cord-252528-rgnhfcbx	189	9	of	of	IN
cord-252528-rgnhfcbx	189	10	SARS	SARS	NNP
cord-252528-rgnhfcbx	189	11	-	-	HYPH
cord-252528-rgnhfcbx	189	12	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	189	13	by	by	IN
cord-252528-rgnhfcbx	189	14	preventing	prevent	VBG
cord-252528-rgnhfcbx	189	15	the	the	DT
cord-252528-rgnhfcbx	189	16	terminal	terminal	JJ
cord-252528-rgnhfcbx	189	17	glycosylation	glycosylation	NN
cord-252528-rgnhfcbx	189	18	of	of	IN
cord-252528-rgnhfcbx	189	19	its	-PRON-	PRP$
cord-252528-rgnhfcbx	189	20	receptor	receptor	NN
cord-252528-rgnhfcbx	189	21	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	189	22	[	[	-LRB-
cord-252528-rgnhfcbx	189	23	72	72	CD
cord-252528-rgnhfcbx	189	24	]	]	-RRB-
cord-252528-rgnhfcbx	189	25	.	.	.
cord-252528-rgnhfcbx	190	1	Therefore	therefore	RB
cord-252528-rgnhfcbx	190	2	,	,	,
cord-252528-rgnhfcbx	190	3	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	190	4	and	and	CC
cord-252528-rgnhfcbx	190	5	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	190	6	can	can	MD
cord-252528-rgnhfcbx	190	7	theoretically	theoretically	RB
cord-252528-rgnhfcbx	190	8	lower	lower	VB
cord-252528-rgnhfcbx	190	9	the	the	DT
cord-252528-rgnhfcbx	190	10	risk	risk	NN
cord-252528-rgnhfcbx	190	11	of	of	IN
cord-252528-rgnhfcbx	190	12	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	190	13	state	state	NN
cord-252528-rgnhfcbx	190	14	and	and	CC
cord-252528-rgnhfcbx	190	15	vascular	vascular	JJ
cord-252528-rgnhfcbx	190	16	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	190	17	by	by	IN
cord-252528-rgnhfcbx	190	18	alleviating	alleviate	VBG
cord-252528-rgnhfcbx	190	19	the	the	DT
cord-252528-rgnhfcbx	190	20	endothelitis	endothelitis	NN
cord-252528-rgnhfcbx	190	21	caused	cause	VBN
cord-252528-rgnhfcbx	190	22	by	by	IN
cord-252528-rgnhfcbx	190	23	direct	direct	JJ
cord-252528-rgnhfcbx	190	24	SARS	SARS	NNP
cord-252528-rgnhfcbx	190	25	-	-	HYPH
cord-252528-rgnhfcbx	190	26	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	190	27	invasion	invasion	NN
cord-252528-rgnhfcbx	190	28	into	into	IN
cord-252528-rgnhfcbx	190	29	the	the	DT
cord-252528-rgnhfcbx	190	30	host	host	NN
cord-252528-rgnhfcbx	190	31	vascular	vascular	JJ
cord-252528-rgnhfcbx	190	32	ECs	ECs	NNP
cord-252528-rgnhfcbx	190	33	in	in	IN
cord-252528-rgnhfcbx	190	34	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	190	35	[	[	-LRB-
cord-252528-rgnhfcbx	190	36	31	31	CD
cord-252528-rgnhfcbx	190	37	]	]	-RRB-
cord-252528-rgnhfcbx	190	38	.	.	.
cord-252528-rgnhfcbx	191	1	SARS	SARS	NNP
cord-252528-rgnhfcbx	191	2	-	-	HYPH
cord-252528-rgnhfcbx	191	3	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	191	4	and	and	CC
cord-252528-rgnhfcbx	191	5	SARS	SARS	NNP
cord-252528-rgnhfcbx	191	6	-	-	HYPH
cord-252528-rgnhfcbx	191	7	CoV	CoV	NNP
cord-252528-rgnhfcbx	191	8	bind	bind	NN
cord-252528-rgnhfcbx	191	9	to	to	IN
cord-252528-rgnhfcbx	191	10	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	191	11	for	for	IN
cord-252528-rgnhfcbx	191	12	cell	cell	NN
cord-252528-rgnhfcbx	191	13	entry	entry	NN
cord-252528-rgnhfcbx	191	14	,	,	,
cord-252528-rgnhfcbx	191	15	and	and	CC
cord-252528-rgnhfcbx	191	16	share	share	VB
cord-252528-rgnhfcbx	191	17	a	a	DT
cord-252528-rgnhfcbx	191	18	similar	similar	JJ
cord-252528-rgnhfcbx	191	19	amino	amino	NN
cord-252528-rgnhfcbx	191	20	acid	acid	NN
cord-252528-rgnhfcbx	191	21	sequence	sequence	NN
cord-252528-rgnhfcbx	191	22	in	in	IN
cord-252528-rgnhfcbx	191	23	their	-PRON-	PRP$
cord-252528-rgnhfcbx	191	24	receptor	receptor	NN
cord-252528-rgnhfcbx	191	25	-	-	HYPH
cord-252528-rgnhfcbx	191	26	binding	bind	VBG
cord-252528-rgnhfcbx	191	27	spike	spike	NN
cord-252528-rgnhfcbx	191	28	proteins	protein	NNS
cord-252528-rgnhfcbx	191	29	,	,	,
cord-252528-rgnhfcbx	191	30	with	with	IN
cord-252528-rgnhfcbx	191	31	a	a	DT
cord-252528-rgnhfcbx	191	32	76	76	CD
cord-252528-rgnhfcbx	191	33	%	%	NN
cord-252528-rgnhfcbx	191	34	amino	amino	NN
cord-252528-rgnhfcbx	191	35	acid	acid	NN
cord-252528-rgnhfcbx	191	36	sequence	sequence	NN
cord-252528-rgnhfcbx	191	37	similarity	similarity	NN
cord-252528-rgnhfcbx	191	38	between	between	IN
cord-252528-rgnhfcbx	191	39	the	the	DT
cord-252528-rgnhfcbx	191	40	spike	spike	NN
cord-252528-rgnhfcbx	191	41	protein	protein	NN
cord-252528-rgnhfcbx	191	42	of	of	IN
cord-252528-rgnhfcbx	191	43	SARS	SARS	NNP
cord-252528-rgnhfcbx	191	44	-	-	HYPH
cord-252528-rgnhfcbx	191	45	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	191	46	and	and	CC
cord-252528-rgnhfcbx	191	47	that	that	DT
cord-252528-rgnhfcbx	191	48	of	of	IN
cord-252528-rgnhfcbx	191	49	SARS	SARS	NNP
cord-252528-rgnhfcbx	191	50	-	-	HYPH
cord-252528-rgnhfcbx	191	51	CoV	CoV	NNP
cord-252528-rgnhfcbx	191	52	S	S	NNP
cord-252528-rgnhfcbx	191	53	Urbani	Urbani	NNP
cord-252528-rgnhfcbx	191	54	[	[	-LRB-
cord-252528-rgnhfcbx	191	55	78	78	CD
cord-252528-rgnhfcbx	191	56	,	,	,
cord-252528-rgnhfcbx	191	57	79	79	CD
cord-252528-rgnhfcbx	191	58	]	]	-RRB-
cord-252528-rgnhfcbx	191	59	.	.	.
cord-252528-rgnhfcbx	192	1	These	these	DT
cord-252528-rgnhfcbx	192	2	two	two	CD
cord-252528-rgnhfcbx	192	3	viruses	virus	NNS
cord-252528-rgnhfcbx	192	4	also	also	RB
cord-252528-rgnhfcbx	192	5	bind	bind	VBP
cord-252528-rgnhfcbx	192	6	to	to	IN
cord-252528-rgnhfcbx	192	7	the	the	DT
cord-252528-rgnhfcbx	192	8	same	same	JJ
cord-252528-rgnhfcbx	192	9	receptor	receptor	NN
cord-252528-rgnhfcbx	192	10	,	,	,
cord-252528-rgnhfcbx	192	11	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	192	12	,	,	,
cord-252528-rgnhfcbx	192	13	for	for	IN
cord-252528-rgnhfcbx	192	14	cell	cell	NN
cord-252528-rgnhfcbx	192	15	entry	entry	NN
cord-252528-rgnhfcbx	192	16	[	[	-LRB-
cord-252528-rgnhfcbx	192	17	78	78	CD
cord-252528-rgnhfcbx	192	18	]	]	-RRB-
cord-252528-rgnhfcbx	192	19	.	.	.
cord-252528-rgnhfcbx	193	1	As	as	IN
cord-252528-rgnhfcbx	193	2	in	in	IN
cord-252528-rgnhfcbx	193	3	the	the	DT
cord-252528-rgnhfcbx	193	4	case	case	NN
cord-252528-rgnhfcbx	193	5	of	of	IN
cord-252528-rgnhfcbx	193	6	SARS	SARS	NNP
cord-252528-rgnhfcbx	193	7	-	-	HYPH
cord-252528-rgnhfcbx	193	8	CoV	CoV	NNP
cord-252528-rgnhfcbx	193	9	infection	infection	NN
cord-252528-rgnhfcbx	193	10	,	,	,
cord-252528-rgnhfcbx	193	11	the	the	DT
cord-252528-rgnhfcbx	193	12	SARS	SARS	NNP
cord-252528-rgnhfcbx	193	13	-	-	HYPH
cord-252528-rgnhfcbx	193	14	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	193	15	spike	spike	NN
cord-252528-rgnhfcbx	193	16	protein	protein	NN
cord-252528-rgnhfcbx	193	17	is	be	VBZ
cord-252528-rgnhfcbx	193	18	primed	prime	VBN
cord-252528-rgnhfcbx	193	19	by	by	IN
cord-252528-rgnhfcbx	193	20	the	the	DT
cord-252528-rgnhfcbx	193	21	transmembrane	transmembrane	NN
cord-252528-rgnhfcbx	193	22	serine	serine	NN
cord-252528-rgnhfcbx	193	23	protease	protease	NN
cord-252528-rgnhfcbx	193	24	2	2	CD
cord-252528-rgnhfcbx	193	25	(	(	-LRB-
cord-252528-rgnhfcbx	193	26	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	193	27	)	)	-RRB-
cord-252528-rgnhfcbx	193	28	,	,	,
cord-252528-rgnhfcbx	193	29	which	which	WDT
cord-252528-rgnhfcbx	193	30	facilitates	facilitate	VBZ
cord-252528-rgnhfcbx	193	31	viral	viral	JJ
cord-252528-rgnhfcbx	193	32	entry	entry	NN
cord-252528-rgnhfcbx	193	33	into	into	IN
cord-252528-rgnhfcbx	193	34	host	host	NN
cord-252528-rgnhfcbx	193	35	cells	cell	NNS
cord-252528-rgnhfcbx	193	36	[	[	-LRB-
cord-252528-rgnhfcbx	193	37	80	80	CD
cord-252528-rgnhfcbx	193	38	]	]	-RRB-
cord-252528-rgnhfcbx	193	39	.	.	.
cord-252528-rgnhfcbx	194	1	A	a	DT
cord-252528-rgnhfcbx	194	2	recent	recent	JJ
cord-252528-rgnhfcbx	194	3	study	study	NN
cord-252528-rgnhfcbx	194	4	using	use	VBG
cord-252528-rgnhfcbx	194	5	single	single	JJ
cord-252528-rgnhfcbx	194	6	-	-	HYPH
cord-252528-rgnhfcbx	194	7	cell	cell	NN
cord-252528-rgnhfcbx	194	8	RNA	rna	NN
cord-252528-rgnhfcbx	194	9	-	-	HYPH
cord-252528-rgnhfcbx	194	10	sequencing	sequence	VBG
cord-252528-rgnhfcbx	194	11	(	(	-LRB-
cord-252528-rgnhfcbx	194	12	scRNA	scRNA	NNP
cord-252528-rgnhfcbx	194	13	-	-	HYPH
cord-252528-rgnhfcbx	194	14	seq	seq	NN
cord-252528-rgnhfcbx	194	15	)	)	-RRB-
cord-252528-rgnhfcbx	194	16	has	have	VBZ
cord-252528-rgnhfcbx	194	17	identified	identify	VBN
cord-252528-rgnhfcbx	194	18	cells	cell	NNS
cord-252528-rgnhfcbx	194	19	with	with	IN
cord-252528-rgnhfcbx	194	20	co	co	NNS
cord-252528-rgnhfcbx	194	21	-	-	NNS
cord-252528-rgnhfcbx	194	22	expressions	expression	NNS
cord-252528-rgnhfcbx	194	23	of	of	IN
cord-252528-rgnhfcbx	194	24	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	194	25	and	and	CC
cord-252528-rgnhfcbx	194	26	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	194	27	,	,	,
cord-252528-rgnhfcbx	194	28	including	include	VBG
cord-252528-rgnhfcbx	194	29	type	type	NN
cord-252528-rgnhfcbx	194	30	II	II	NNP
cord-252528-rgnhfcbx	194	31	pneumocytes	pneumocyte	NNS
cord-252528-rgnhfcbx	194	32	,	,	,
cord-252528-rgnhfcbx	194	33	ileal	ileal	JJ
cord-252528-rgnhfcbx	194	34	enterocytes	enterocyte	NNS
cord-252528-rgnhfcbx	194	35	,	,	,
cord-252528-rgnhfcbx	194	36	and	and	CC
cord-252528-rgnhfcbx	194	37	nasal	nasal	JJ
cord-252528-rgnhfcbx	194	38	goblet	goblet	NN
cord-252528-rgnhfcbx	194	39	cells	cell	NNS
cord-252528-rgnhfcbx	194	40	[	[	-LRB-
cord-252528-rgnhfcbx	194	41	81	81	CD
cord-252528-rgnhfcbx	194	42	]	]	-RRB-
cord-252528-rgnhfcbx	194	43	.	.	.
cord-252528-rgnhfcbx	195	1	These	these	DT
cord-252528-rgnhfcbx	195	2	cells	cell	NNS
cord-252528-rgnhfcbx	195	3	are	be	VBP
cord-252528-rgnhfcbx	195	4	,	,	,
cord-252528-rgnhfcbx	195	5	therefore	therefore	RB
cord-252528-rgnhfcbx	195	6	,	,	,
cord-252528-rgnhfcbx	195	7	targets	target	NNS
cord-252528-rgnhfcbx	195	8	for	for	IN
cord-252528-rgnhfcbx	195	9	SARS	SARS	NNP
cord-252528-rgnhfcbx	195	10	-	-	HYPH
cord-252528-rgnhfcbx	195	11	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	195	12	invasion	invasion	NN
cord-252528-rgnhfcbx	195	13	in	in	IN
cord-252528-rgnhfcbx	195	14	the	the	DT
cord-252528-rgnhfcbx	195	15	host	host	NN
cord-252528-rgnhfcbx	195	16	.	.	.
cord-252528-rgnhfcbx	196	1	Interactome	Interactome	NNP
cord-252528-rgnhfcbx	196	2	model	model	NN
cord-252528-rgnhfcbx	196	3	for	for	IN
cord-252528-rgnhfcbx	196	4	interactions	interaction	NNS
cord-252528-rgnhfcbx	196	5	between	between	IN
cord-252528-rgnhfcbx	196	6	SARS	SARS	NNP
cord-252528-rgnhfcbx	196	7	-	-	HYPH
cord-252528-rgnhfcbx	196	8	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	196	9	and	and	CC
cord-252528-rgnhfcbx	196	10	human	human	JJ
cord-252528-rgnhfcbx	196	11	cell	cell	NN
cord-252528-rgnhfcbx	196	12	,	,	,
cord-252528-rgnhfcbx	196	13	based	base	VBN
cord-252528-rgnhfcbx	196	14	on	on	IN
cord-252528-rgnhfcbx	196	15	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	196	16	of	of	IN
cord-252528-rgnhfcbx	196	17	human	human	JJ
cord-252528-rgnhfcbx	196	18	protein/	protein/	NNP
cord-252528-rgnhfcbx	196	19	SARS	SARS	NNP
cord-252528-rgnhfcbx	196	20	-	-	HYPH
cord-252528-rgnhfcbx	196	21	CoV	CoV	NNP
cord-252528-rgnhfcbx	196	22	and	and	CC
cord-252528-rgnhfcbx	196	23	human	human	JJ
cord-252528-rgnhfcbx	196	24	protein	protein	NN
cord-252528-rgnhfcbx	196	25	/	/	SYM
cord-252528-rgnhfcbx	196	26	MERS	MERS	NNP
cord-252528-rgnhfcbx	196	27	-	-	HYPH
cord-252528-rgnhfcbx	196	28	CoV	CoV	NNP
cord-252528-rgnhfcbx	196	29	interactions	interaction	NNS
cord-252528-rgnhfcbx	196	30	,	,	,
cord-252528-rgnhfcbx	196	31	predicts	predict	VBZ
cord-252528-rgnhfcbx	196	32	a	a	DT
cord-252528-rgnhfcbx	196	33	down	down	RB
cord-252528-rgnhfcbx	196	34	-	-	HYPH
cord-252528-rgnhfcbx	196	35	regulating	regulating	NN
cord-252528-rgnhfcbx	196	36	effect	effect	NN
cord-252528-rgnhfcbx	196	37	of	of	IN
cord-252528-rgnhfcbx	196	38	SARS	SARS	NNP
cord-252528-rgnhfcbx	196	39	-	-	HYPH
cord-252528-rgnhfcbx	196	40	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	196	41	infection	infection	NN
cord-252528-rgnhfcbx	196	42	on	on	IN
cord-252528-rgnhfcbx	196	43	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	196	44	expression	expression	NN
cord-252528-rgnhfcbx	196	45	in	in	IN
cord-252528-rgnhfcbx	196	46	human	human	JJ
cord-252528-rgnhfcbx	196	47	cells	cell	NNS
cord-252528-rgnhfcbx	196	48	[	[	-LRB-
cord-252528-rgnhfcbx	196	49	7	7	CD
cord-252528-rgnhfcbx	196	50	]	]	-RRB-
cord-252528-rgnhfcbx	196	51	.	.	.
cord-252528-rgnhfcbx	197	1	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	197	2	protein	protein	NN
cord-252528-rgnhfcbx	197	3	expression	expression	NN
cord-252528-rgnhfcbx	197	4	is	be	VBZ
cord-252528-rgnhfcbx	197	5	found	find	VBN
cord-252528-rgnhfcbx	197	6	in	in	IN
cord-252528-rgnhfcbx	197	7	multiple	multiple	JJ
cord-252528-rgnhfcbx	197	8	organs	organ	NNS
cord-252528-rgnhfcbx	197	9	and	and	CC
cord-252528-rgnhfcbx	197	10	tissues	tissue	NNS
cord-252528-rgnhfcbx	197	11	,	,	,
cord-252528-rgnhfcbx	197	12	including	include	VBG
cord-252528-rgnhfcbx	197	13	vascular	vascular	JJ
cord-252528-rgnhfcbx	197	14	ECs	ec	NNS
cord-252528-rgnhfcbx	197	15	and	and	CC
cord-252528-rgnhfcbx	197	16	SMCs	smc	NNS
cord-252528-rgnhfcbx	197	17	[	[	-LRB-
cord-252528-rgnhfcbx	197	18	82	82	CD
cord-252528-rgnhfcbx	197	19	]	]	-RRB-
cord-252528-rgnhfcbx	197	20	.	.	.
cord-252528-rgnhfcbx	198	1	Both	both	DT
cord-252528-rgnhfcbx	198	2	in	in	IN
cord-252528-rgnhfcbx	198	3	vitro	vitro	FW
cord-252528-rgnhfcbx	198	4	and	and	CC
cord-252528-rgnhfcbx	198	5	in	in	IN
cord-252528-rgnhfcbx	198	6	vivo	vivo	NN
cord-252528-rgnhfcbx	198	7	experiments	experiment	NNS
cord-252528-rgnhfcbx	198	8	have	have	VBP
cord-252528-rgnhfcbx	198	9	pointed	point	VBN
cord-252528-rgnhfcbx	198	10	out	out	RP
cord-252528-rgnhfcbx	198	11	the	the	DT
cord-252528-rgnhfcbx	198	12	role	role	NN
cord-252528-rgnhfcbx	198	13	of	of	IN
cord-252528-rgnhfcbx	198	14	SARS	SARS	NNP
cord-252528-rgnhfcbx	198	15	-	-	HYPH
cord-252528-rgnhfcbx	198	16	CoV	CoV	NNP
cord-252528-rgnhfcbx	198	17	spike	spike	NN
cord-252528-rgnhfcbx	198	18	protein	protein	NN
cord-252528-rgnhfcbx	198	19	in	in	IN
cord-252528-rgnhfcbx	198	20	down	down	RB
cord-252528-rgnhfcbx	198	21	-	-	HYPH
cord-252528-rgnhfcbx	198	22	regulating	regulate	VBG
cord-252528-rgnhfcbx	198	23	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	198	24	expression	expression	NN
cord-252528-rgnhfcbx	198	25	through	through	IN
cord-252528-rgnhfcbx	198	26	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	198	27	binding	bind	VBG
cord-252528-rgnhfcbx	198	28	[	[	-LRB-
cord-252528-rgnhfcbx	198	29	83	83	CD
cord-252528-rgnhfcbx	198	30	]	]	-RRB-
cord-252528-rgnhfcbx	198	31	.	.	.
cord-252528-rgnhfcbx	199	1	SARS	SARS	NNP
cord-252528-rgnhfcbx	199	2	-	-	HYPH
cord-252528-rgnhfcbx	199	3	CoV	CoV	NNP
cord-252528-rgnhfcbx	199	4	infection	infection	NN
cord-252528-rgnhfcbx	199	5	can	can	MD
cord-252528-rgnhfcbx	199	6	result	result	VB
cord-252528-rgnhfcbx	199	7	in	in	IN
cord-252528-rgnhfcbx	199	8	a	a	DT
cord-252528-rgnhfcbx	199	9	reduction	reduction	NN
cord-252528-rgnhfcbx	199	10	in	in	IN
cord-252528-rgnhfcbx	199	11	myocardial	myocardial	JJ
cord-252528-rgnhfcbx	199	12	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	199	13	expression	expression	NN
cord-252528-rgnhfcbx	199	14	at	at	IN
cord-252528-rgnhfcbx	199	15	mRNA	mrna	NN
cord-252528-rgnhfcbx	199	16	and	and	CC
cord-252528-rgnhfcbx	199	17	protein	protein	NN
cord-252528-rgnhfcbx	199	18	levels	level	NNS
cord-252528-rgnhfcbx	199	19	in	in	IN
cord-252528-rgnhfcbx	199	20	mice	mouse	NNS
cord-252528-rgnhfcbx	199	21	[	[	-LRB-
cord-252528-rgnhfcbx	199	22	84	84	CD
cord-252528-rgnhfcbx	199	23	]	]	-RRB-
cord-252528-rgnhfcbx	199	24	.	.	.
cord-252528-rgnhfcbx	200	1	In	in	IN
cord-252528-rgnhfcbx	200	2	vitro	vitro	FW
cord-252528-rgnhfcbx	200	3	experiments	experiment	NNS
cord-252528-rgnhfcbx	200	4	have	have	VBP
cord-252528-rgnhfcbx	200	5	proved	prove	VBN
cord-252528-rgnhfcbx	200	6	the	the	DT
cord-252528-rgnhfcbx	200	7	ability	ability	NN
cord-252528-rgnhfcbx	200	8	of	of	IN
cord-252528-rgnhfcbx	200	9	SARS	SARS	NNP
cord-252528-rgnhfcbx	200	10	-	-	HYPH
cord-252528-rgnhfcbx	200	11	CoV	CoV	NNP
cord-252528-rgnhfcbx	200	12	spike	spike	NN
cord-252528-rgnhfcbx	200	13	protein	protein	NN
cord-252528-rgnhfcbx	200	14	to	to	TO
cord-252528-rgnhfcbx	200	15	induce	induce	VB
cord-252528-rgnhfcbx	200	16	the	the	DT
cord-252528-rgnhfcbx	200	17	activity	activity	NN
cord-252528-rgnhfcbx	200	18	of	of	IN
cord-252528-rgnhfcbx	200	19	a	a	DT
cord-252528-rgnhfcbx	200	20	disintegrin	disintegrin	NNP
cord-252528-rgnhfcbx	200	21	and	and	CC
cord-252528-rgnhfcbx	200	22	metalloprotease	metalloprotease	NNP
cord-252528-rgnhfcbx	200	23	(	(	-LRB-
cord-252528-rgnhfcbx	200	24	ADAM17	ADAM17	NNP
cord-252528-rgnhfcbx	200	25	)	)	-RRB-
cord-252528-rgnhfcbx	200	26	,	,	,
cord-252528-rgnhfcbx	200	27	which	which	WDT
cord-252528-rgnhfcbx	200	28	sheds	shed	VBZ
cord-252528-rgnhfcbx	200	29	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	200	30	from	from	IN
cord-252528-rgnhfcbx	200	31	the	the	DT
cord-252528-rgnhfcbx	200	32	membrane	membrane	NN
cord-252528-rgnhfcbx	200	33	,	,	,
cord-252528-rgnhfcbx	200	34	down	down	RB
cord-252528-rgnhfcbx	200	35	-	-	HYPH
cord-252528-rgnhfcbx	200	36	regulating	regulate	VBG
cord-252528-rgnhfcbx	200	37	the	the	DT
cord-252528-rgnhfcbx	200	38	expression	expression	NN
cord-252528-rgnhfcbx	200	39	of	of	IN
cord-252528-rgnhfcbx	200	40	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	200	41	in	in	IN
cord-252528-rgnhfcbx	200	42	Vero	Vero	NNP
cord-252528-rgnhfcbx	200	43	E6	E6	NNP
cord-252528-rgnhfcbx	200	44	cells	cell	NNS
cord-252528-rgnhfcbx	200	45	[	[	-LRB-
cord-252528-rgnhfcbx	200	46	85	85	CD
cord-252528-rgnhfcbx	200	47	]	]	-RRB-
cord-252528-rgnhfcbx	200	48	.	.	.
cord-252528-rgnhfcbx	201	1	Although	although	IN
cord-252528-rgnhfcbx	201	2	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	201	3	may	may	MD
cord-252528-rgnhfcbx	201	4	interfere	interfere	VB
cord-252528-rgnhfcbx	201	5	with	with	IN
cord-252528-rgnhfcbx	201	6	the	the	DT
cord-252528-rgnhfcbx	201	7	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	201	8	shedding	shed	VBG
cord-252528-rgnhfcbx	201	9	activity	activity	NN
cord-252528-rgnhfcbx	201	10	of	of	IN
cord-252528-rgnhfcbx	201	11	ADAM17	ADAM17	NNP
cord-252528-rgnhfcbx	201	12	,	,	,
cord-252528-rgnhfcbx	201	13	coexpressions	coexpression	NNS
cord-252528-rgnhfcbx	201	14	of	of	IN
cord-252528-rgnhfcbx	201	15	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	201	16	and	and	CC
cord-252528-rgnhfcbx	201	17	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	201	18	can	can	MD
cord-252528-rgnhfcbx	201	19	only	only	RB
cord-252528-rgnhfcbx	201	20	be	be	VB
cord-252528-rgnhfcbx	201	21	found	find	VBN
cord-252528-rgnhfcbx	201	22	in	in	IN
cord-252528-rgnhfcbx	201	23	restricted	restricted	JJ
cord-252528-rgnhfcbx	201	24	types	type	NNS
cord-252528-rgnhfcbx	201	25	of	of	IN
cord-252528-rgnhfcbx	201	26	cells	cell	NNS
cord-252528-rgnhfcbx	201	27	,	,	,
cord-252528-rgnhfcbx	201	28	as	as	IN
cord-252528-rgnhfcbx	201	29	indicated	indicate	VBN
cord-252528-rgnhfcbx	201	30	by	by	IN
cord-252528-rgnhfcbx	201	31	the	the	DT
cord-252528-rgnhfcbx	201	32	result	result	NN
cord-252528-rgnhfcbx	201	33	of	of	IN
cord-252528-rgnhfcbx	201	34	the	the	DT
cord-252528-rgnhfcbx	201	35	recent	recent	JJ
cord-252528-rgnhfcbx	201	36	scRNA	scrna	JJ
cord-252528-rgnhfcbx	201	37	-	-	HYPH
cord-252528-rgnhfcbx	201	38	seq	seq	NN
cord-252528-rgnhfcbx	201	39	experiment	experiment	NN
cord-252528-rgnhfcbx	201	40	[	[	-LRB-
cord-252528-rgnhfcbx	201	41	81	81	CD
cord-252528-rgnhfcbx	201	42	,	,	,
cord-252528-rgnhfcbx	201	43	86	86	CD
cord-252528-rgnhfcbx	201	44	]	]	-RRB-
cord-252528-rgnhfcbx	201	45	.	.	.
cord-252528-rgnhfcbx	202	1	Due	due	IN
cord-252528-rgnhfcbx	202	2	to	to	IN
cord-252528-rgnhfcbx	202	3	the	the	DT
cord-252528-rgnhfcbx	202	4	similarity	similarity	NN
cord-252528-rgnhfcbx	202	5	between	between	IN
cord-252528-rgnhfcbx	202	6	amino	amino	NN
cord-252528-rgnhfcbx	202	7	acid	acid	NN
cord-252528-rgnhfcbx	202	8	sequences	sequence	NNS
cord-252528-rgnhfcbx	202	9	of	of	IN
cord-252528-rgnhfcbx	202	10	SARS	SARS	NNP
cord-252528-rgnhfcbx	202	11	-	-	HYPH
cord-252528-rgnhfcbx	202	12	CoV	CoV	NNP
cord-252528-rgnhfcbx	202	13	and	and	CC
cord-252528-rgnhfcbx	202	14	SARS	SARS	NNP
cord-252528-rgnhfcbx	202	15	-	-	HYPH
cord-252528-rgnhfcbx	202	16	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	202	17	spike	spike	NN
cord-252528-rgnhfcbx	202	18	proteins	protein	NNS
cord-252528-rgnhfcbx	202	19	,	,	,
cord-252528-rgnhfcbx	202	20	SARS	SARS	NNP
cord-252528-rgnhfcbx	202	21	-	-	HYPH
cord-252528-rgnhfcbx	202	22	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	202	23	could	could	MD
cord-252528-rgnhfcbx	202	24	lead	lead	VB
cord-252528-rgnhfcbx	202	25	to	to	IN
cord-252528-rgnhfcbx	202	26	a	a	DT
cord-252528-rgnhfcbx	202	27	downregulation	downregulation	NN
cord-252528-rgnhfcbx	202	28	in	in	IN
cord-252528-rgnhfcbx	202	29	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	202	30	expression	expression	NN
cord-252528-rgnhfcbx	202	31	in	in	IN
cord-252528-rgnhfcbx	202	32	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	202	33	through	through	IN
cord-252528-rgnhfcbx	202	34	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	202	35	binding	binding	NN
cord-252528-rgnhfcbx	202	36	.	.	.
cord-252528-rgnhfcbx	203	1	However	however	RB
cord-252528-rgnhfcbx	203	2	,	,	,
cord-252528-rgnhfcbx	203	3	further	further	JJ
cord-252528-rgnhfcbx	203	4	experiments	experiment	NNS
cord-252528-rgnhfcbx	203	5	using	use	VBG
cord-252528-rgnhfcbx	203	6	animal	animal	NN
cord-252528-rgnhfcbx	203	7	models	model	NNS
cord-252528-rgnhfcbx	203	8	with	with	IN
cord-252528-rgnhfcbx	203	9	SARS	SARS	NNP
cord-252528-rgnhfcbx	203	10	-	-	HYPH
cord-252528-rgnhfcbx	203	11	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	203	12	infection	infection	NN
cord-252528-rgnhfcbx	203	13	are	be	VBP
cord-252528-rgnhfcbx	203	14	still	still	RB
cord-252528-rgnhfcbx	203	15	required	require	VBN
cord-252528-rgnhfcbx	203	16	to	to	TO
cord-252528-rgnhfcbx	203	17	better	well	RBR
cord-252528-rgnhfcbx	203	18	clarify	clarify	VB
cord-252528-rgnhfcbx	203	19	the	the	DT
cord-252528-rgnhfcbx	203	20	effect	effect	NN
cord-252528-rgnhfcbx	203	21	of	of	IN
cord-252528-rgnhfcbx	203	22	SARS	SARS	NNP
cord-252528-rgnhfcbx	203	23	-	-	HYPH
cord-252528-rgnhfcbx	203	24	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	203	25	infection	infection	NN
cord-252528-rgnhfcbx	203	26	on	on	IN
cord-252528-rgnhfcbx	203	27	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	203	28	expression	expression	NN
cord-252528-rgnhfcbx	203	29	in	in	IN
cord-252528-rgnhfcbx	203	30	different	different	JJ
cord-252528-rgnhfcbx	203	31	tissues	tissue	NNS
cord-252528-rgnhfcbx	203	32	or	or	CC
cord-252528-rgnhfcbx	203	33	cell	cell	NN
cord-252528-rgnhfcbx	203	34	types	type	NNS
cord-252528-rgnhfcbx	203	35	.	.	.
cord-252528-rgnhfcbx	204	1	Ang	Ang	NNP
cord-252528-rgnhfcbx	204	2	II	II	NNP
cord-252528-rgnhfcbx	204	3	(	(	-LRB-
cord-252528-rgnhfcbx	204	4	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	204	5	II	II	NNP
cord-252528-rgnhfcbx	204	6	)	)	-RRB-
cord-252528-rgnhfcbx	204	7	is	be	VBZ
cord-252528-rgnhfcbx	204	8	the	the	DT
cord-252528-rgnhfcbx	204	9	effector	effector	NN
cord-252528-rgnhfcbx	204	10	molecule	molecule	NN
cord-252528-rgnhfcbx	204	11	in	in	IN
cord-252528-rgnhfcbx	204	12	the	the	DT
cord-252528-rgnhfcbx	204	13	ACE/	ACE/	NNP
cord-252528-rgnhfcbx	204	14	Ang	Ang	NNP
cord-252528-rgnhfcbx	204	15	II	II	NNP
cord-252528-rgnhfcbx	204	16	/	/	SYM
cord-252528-rgnhfcbx	204	17	AT1	AT1	NNP
cord-252528-rgnhfcbx	204	18	receptor	receptor	NN
cord-252528-rgnhfcbx	204	19	(	(	-LRB-
cord-252528-rgnhfcbx	204	20	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	204	21	II	II	NNP
cord-252528-rgnhfcbx	204	22	receptor	receptor	NN
cord-252528-rgnhfcbx	204	23	type	type	NN
cord-252528-rgnhfcbx	204	24	1	1	CD
cord-252528-rgnhfcbx	204	25	)	)	-RRB-
cord-252528-rgnhfcbx	204	26	axis	axis	NN
cord-252528-rgnhfcbx	204	27	,	,	,
cord-252528-rgnhfcbx	204	28	associated	associate	VBN
cord-252528-rgnhfcbx	204	29	with	with	IN
cord-252528-rgnhfcbx	204	30	pro	pro	JJ
cord-252528-rgnhfcbx	204	31	-	-	JJ
cord-252528-rgnhfcbx	204	32	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	204	33	activities	activity	NNS
cord-252528-rgnhfcbx	204	34	including	include	VBG
cord-252528-rgnhfcbx	204	35	increased	increase	VBN
cord-252528-rgnhfcbx	204	36	TF	TF	NNP
cord-252528-rgnhfcbx	204	37	and	and	CC
cord-252528-rgnhfcbx	204	38	PAI-1	PAI-1	NNP
cord-252528-rgnhfcbx	204	39	production	production	NN
cord-252528-rgnhfcbx	204	40	by	by	IN
cord-252528-rgnhfcbx	204	41	aortic	aortic	JJ
cord-252528-rgnhfcbx	204	42	ECs	ec	NNS
cord-252528-rgnhfcbx	204	43	and	and	CC
cord-252528-rgnhfcbx	204	44	SMCs	SMCs	NNP
cord-252528-rgnhfcbx	204	45	[	[	-LRB-
cord-252528-rgnhfcbx	204	46	87	87	CD
cord-252528-rgnhfcbx	204	47	,	,	,
cord-252528-rgnhfcbx	204	48	88	88	CD
cord-252528-rgnhfcbx	204	49	]	]	-RRB-
cord-252528-rgnhfcbx	204	50	.	.	.
cord-252528-rgnhfcbx	205	1	Upon	upon	IN
cord-252528-rgnhfcbx	205	2	binding	bind	VBG
cord-252528-rgnhfcbx	205	3	to	to	IN
cord-252528-rgnhfcbx	205	4	AT1R	AT1R	NNP
cord-252528-rgnhfcbx	205	5	,	,	,
cord-252528-rgnhfcbx	205	6	Ang	Ang	NNP
cord-252528-rgnhfcbx	205	7	II	II	NNP
cord-252528-rgnhfcbx	205	8	can	can	MD
cord-252528-rgnhfcbx	205	9	induce	induce	VB
cord-252528-rgnhfcbx	205	10	ROS	ROS	NNP
cord-252528-rgnhfcbx	205	11	production	production	NN
cord-252528-rgnhfcbx	205	12	by	by	IN
cord-252528-rgnhfcbx	205	13	stimulating	stimulate	VBG
cord-252528-rgnhfcbx	205	14	the	the	DT
cord-252528-rgnhfcbx	205	15	activity	activity	NN
cord-252528-rgnhfcbx	205	16	of	of	IN
cord-252528-rgnhfcbx	205	17	NADH	NADH	NNP
cord-252528-rgnhfcbx	205	18	and	and	CC
cord-252528-rgnhfcbx	205	19	NADPH	NADPH	NNP
cord-252528-rgnhfcbx	205	20	oxidases	oxidase	NNS
cord-252528-rgnhfcbx	205	21	in	in	IN
cord-252528-rgnhfcbx	205	22	vascular	vascular	JJ
cord-252528-rgnhfcbx	205	23	SMCs	smc	NNS
cord-252528-rgnhfcbx	205	24	,	,	,
cord-252528-rgnhfcbx	205	25	promoting	promote	VBG
cord-252528-rgnhfcbx	205	26	oxidative	oxidative	JJ
cord-252528-rgnhfcbx	205	27	stress	stress	NN
cord-252528-rgnhfcbx	205	28	and	and	CC
cord-252528-rgnhfcbx	205	29	vascular	vascular	JJ
cord-252528-rgnhfcbx	205	30	inflammation	inflammation	NN
cord-252528-rgnhfcbx	205	31	,	,	,
cord-252528-rgnhfcbx	205	32	which	which	WDT
cord-252528-rgnhfcbx	205	33	can	can	MD
cord-252528-rgnhfcbx	205	34	lead	lead	VB
cord-252528-rgnhfcbx	205	35	to	to	IN
cord-252528-rgnhfcbx	205	36	vascular	vascular	JJ
cord-252528-rgnhfcbx	205	37	injury	injury	NN
cord-252528-rgnhfcbx	205	38	and	and	CC
cord-252528-rgnhfcbx	205	39	thrombus	thrombus	NN
cord-252528-rgnhfcbx	205	40	formation	formation	NN
cord-252528-rgnhfcbx	205	41	[	[	-LRB-
cord-252528-rgnhfcbx	205	42	89	89	CD
cord-252528-rgnhfcbx	205	43	]	]	-RRB-
cord-252528-rgnhfcbx	205	44	.	.	.
cord-252528-rgnhfcbx	206	1	Many	many	JJ
cord-252528-rgnhfcbx	206	2	pieces	piece	NNS
cord-252528-rgnhfcbx	206	3	of	of	IN
cord-252528-rgnhfcbx	206	4	experimental	experimental	JJ
cord-252528-rgnhfcbx	206	5	evidence	evidence	NN
cord-252528-rgnhfcbx	206	6	have	have	VBP
cord-252528-rgnhfcbx	206	7	suggested	suggest	VBN
cord-252528-rgnhfcbx	206	8	the	the	DT
cord-252528-rgnhfcbx	206	9	anti	anti	JJ
cord-252528-rgnhfcbx	206	10	-	-	JJ
cord-252528-rgnhfcbx	206	11	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	206	12	activity	activity	NN
cord-252528-rgnhfcbx	206	13	of	of	IN
cord-252528-rgnhfcbx	206	14	the	the	DT
cord-252528-rgnhfcbx	206	15	ACE2/	ACE2/	NNP
cord-252528-rgnhfcbx	207	1	Ang	Ang	NNP
cord-252528-rgnhfcbx	207	2	1	1	CD
cord-252528-rgnhfcbx	207	3	-	-	SYM
cord-252528-rgnhfcbx	207	4	7	7	CD
cord-252528-rgnhfcbx	208	1	(	(	-LRB-
cord-252528-rgnhfcbx	208	2	Angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	208	3	1	1	CD
cord-252528-rgnhfcbx	208	4	-	-	HYPH
cord-252528-rgnhfcbx	208	5	7)/Mas	7)/mas	CD
cord-252528-rgnhfcbx	208	6	receptor	receptor	NN
cord-252528-rgnhfcbx	208	7	axis	axis	NN
cord-252528-rgnhfcbx	208	8	.	.	.
cord-252528-rgnhfcbx	209	1	In	in	IN
cord-252528-rgnhfcbx	209	2	rats	rat	NNS
cord-252528-rgnhfcbx	209	3	,	,	,
cord-252528-rgnhfcbx	209	4	low	low	JJ
cord-252528-rgnhfcbx	209	5	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	209	6	activity	activity	NN
cord-252528-rgnhfcbx	209	7	is	be	VBZ
cord-252528-rgnhfcbx	209	8	related	relate	VBN
cord-252528-rgnhfcbx	209	9	to	to	IN
cord-252528-rgnhfcbx	209	10	thrombus	thrombus	NN
cord-252528-rgnhfcbx	209	11	formation	formation	NN
cord-252528-rgnhfcbx	209	12	,	,	,
cord-252528-rgnhfcbx	209	13	whereas	whereas	IN
cord-252528-rgnhfcbx	209	14	enhancing	enhance	VBG
cord-252528-rgnhfcbx	209	15	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	209	16	activity	activity	NN
cord-252528-rgnhfcbx	209	17	decreases	decrease	VBZ
cord-252528-rgnhfcbx	209	18	both	both	CC
cord-252528-rgnhfcbx	209	19	platelet	platelet	NN
cord-252528-rgnhfcbx	209	20	accumulation	accumulation	NN
cord-252528-rgnhfcbx	209	21	and	and	CC
cord-252528-rgnhfcbx	209	22	size	size	NN
cord-252528-rgnhfcbx	209	23	of	of	IN
cord-252528-rgnhfcbx	209	24	thrombi	thrombi	NNP
cord-252528-rgnhfcbx	209	25	,	,	,
cord-252528-rgnhfcbx	209	26	delaying	delay	VBG
cord-252528-rgnhfcbx	209	27	the	the	DT
cord-252528-rgnhfcbx	209	28	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	209	29	[	[	-LRB-
cord-252528-rgnhfcbx	209	30	90	90	CD
cord-252528-rgnhfcbx	209	31	]	]	-RRB-
cord-252528-rgnhfcbx	209	32	.	.	.
cord-252528-rgnhfcbx	210	1	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	210	2	catalyzes	catalyze	VBZ
cord-252528-rgnhfcbx	210	3	Ang	Ang	NNP
cord-252528-rgnhfcbx	210	4	II	II	NNP
cord-252528-rgnhfcbx	210	5	to	to	IN
cord-252528-rgnhfcbx	210	6	Ang	Ang	NNP
cord-252528-rgnhfcbx	210	7	1	1	CD
cord-252528-rgnhfcbx	210	8	-	-	SYM
cord-252528-rgnhfcbx	210	9	7	7	CD
cord-252528-rgnhfcbx	210	10	,	,	,
cord-252528-rgnhfcbx	210	11	which	which	WDT
cord-252528-rgnhfcbx	210	12	does	do	VBZ
cord-252528-rgnhfcbx	210	13	not	not	RB
cord-252528-rgnhfcbx	210	14	have	have	VB
cord-252528-rgnhfcbx	210	15	the	the	DT
cord-252528-rgnhfcbx	210	16	pro	pro	JJ
cord-252528-rgnhfcbx	210	17	-	-	JJ
cord-252528-rgnhfcbx	210	18	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	210	19	functions	function	NNS
cord-252528-rgnhfcbx	210	20	associated	associate	VBN
cord-252528-rgnhfcbx	210	21	with	with	IN
cord-252528-rgnhfcbx	210	22	Ang	Ang	NNP
cord-252528-rgnhfcbx	210	23	II	II	NNP
cord-252528-rgnhfcbx	210	24	[	[	-LRB-
cord-252528-rgnhfcbx	210	25	91	91	CD
cord-252528-rgnhfcbx	210	26	]	]	-RRB-
cord-252528-rgnhfcbx	210	27	,	,	,
cord-252528-rgnhfcbx	210	28	preventing	prevent	VBG
cord-252528-rgnhfcbx	210	29	the	the	DT
cord-252528-rgnhfcbx	210	30	adverse	adverse	JJ
cord-252528-rgnhfcbx	210	31	effect	effect	NN
cord-252528-rgnhfcbx	210	32	of	of	IN
cord-252528-rgnhfcbx	210	33	Ang	Ang	NNP
cord-252528-rgnhfcbx	210	34	II	II	NNP
cord-252528-rgnhfcbx	210	35	on	on	IN
cord-252528-rgnhfcbx	210	36	vascular	vascular	JJ
cord-252528-rgnhfcbx	210	37	injury	injury	NN
cord-252528-rgnhfcbx	210	38	and	and	CC
cord-252528-rgnhfcbx	210	39	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	210	40	[	[	-LRB-
cord-252528-rgnhfcbx	210	41	92	92	CD
cord-252528-rgnhfcbx	210	42	]	]	-RRB-
cord-252528-rgnhfcbx	210	43	.	.	.
cord-252528-rgnhfcbx	211	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	211	2	,	,	,
cord-252528-rgnhfcbx	211	3	Ang	Ang	NNP
cord-252528-rgnhfcbx	211	4	1	1	CD
cord-252528-rgnhfcbx	211	5	-	-	SYM
cord-252528-rgnhfcbx	211	6	7	7	CD
cord-252528-rgnhfcbx	211	7	can	can	MD
cord-252528-rgnhfcbx	211	8	promote	promote	VB
cord-252528-rgnhfcbx	211	9	platelet	platelet	NN
cord-252528-rgnhfcbx	211	10	NO	no	DT
cord-252528-rgnhfcbx	211	11	release	release	NN
cord-252528-rgnhfcbx	211	12	by	by	IN
cord-252528-rgnhfcbx	211	13	binding	bind	VBG
cord-252528-rgnhfcbx	211	14	to	to	IN
cord-252528-rgnhfcbx	211	15	the	the	DT
cord-252528-rgnhfcbx	211	16	Mas	Mas	NNP
cord-252528-rgnhfcbx	211	17	receptor	receptor	NN
cord-252528-rgnhfcbx	211	18	on	on	IN
cord-252528-rgnhfcbx	211	19	the	the	DT
cord-252528-rgnhfcbx	211	20	platelet	platelet	NN
cord-252528-rgnhfcbx	211	21	[	[	-LRB-
cord-252528-rgnhfcbx	211	22	93	93	CD
cord-252528-rgnhfcbx	211	23	]	]	-RRB-
cord-252528-rgnhfcbx	211	24	.	.	.
cord-252528-rgnhfcbx	212	1	Therefore	therefore	RB
cord-252528-rgnhfcbx	212	2	,	,	,
cord-252528-rgnhfcbx	212	3	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	212	4	down	down	NN
cord-252528-rgnhfcbx	212	5	-	-	HYPH
cord-252528-rgnhfcbx	212	6	regulation	regulation	NN
cord-252528-rgnhfcbx	212	7	,	,	,
cord-252528-rgnhfcbx	212	8	which	which	WDT
cord-252528-rgnhfcbx	212	9	possibly	possibly	RB
cord-252528-rgnhfcbx	212	10	occurs	occur	VBZ
cord-252528-rgnhfcbx	212	11	in	in	IN
cord-252528-rgnhfcbx	212	12	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	212	13	,	,	,
cord-252528-rgnhfcbx	212	14	enhances	enhance	VBZ
cord-252528-rgnhfcbx	212	15	the	the	DT
cord-252528-rgnhfcbx	212	16	activation	activation	NN
cord-252528-rgnhfcbx	212	17	of	of	IN
cord-252528-rgnhfcbx	212	18	the	the	DT
cord-252528-rgnhfcbx	212	19	ACE/	ACE/	NNP
cord-252528-rgnhfcbx	212	20	Ang	Ang	NNP
cord-252528-rgnhfcbx	212	21	II	II	NNP
cord-252528-rgnhfcbx	212	22	/	/	SYM
cord-252528-rgnhfcbx	212	23	AT1	at1	NN
cord-252528-rgnhfcbx	212	24	receptor	receptor	NN
cord-252528-rgnhfcbx	212	25	axis	axis	NN
cord-252528-rgnhfcbx	212	26	.	.	.
cord-252528-rgnhfcbx	213	1	In	in	IN
cord-252528-rgnhfcbx	213	2	addition	addition	NN
cord-252528-rgnhfcbx	213	3	to	to	IN
cord-252528-rgnhfcbx	213	4	the	the	DT
cord-252528-rgnhfcbx	213	5	pro	pro	JJ
cord-252528-rgnhfcbx	213	6	-	-	JJ
cord-252528-rgnhfcbx	213	7	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	213	8	activities	activity	NNS
cord-252528-rgnhfcbx	213	9	of	of	IN
cord-252528-rgnhfcbx	213	10	the	the	DT
cord-252528-rgnhfcbx	213	11	ACE	ACE	NNP
cord-252528-rgnhfcbx	213	12	/	/	SYM
cord-252528-rgnhfcbx	213	13	Ang	Ang	NNP
cord-252528-rgnhfcbx	213	14	II	II	NNP
cord-252528-rgnhfcbx	213	15	/	/	SYM
cord-252528-rgnhfcbx	213	16	AT1	at1	NN
cord-252528-rgnhfcbx	213	17	receptor	receptor	NN
cord-252528-rgnhfcbx	213	18	axis	axis	NN
cord-252528-rgnhfcbx	213	19	,	,	,
cord-252528-rgnhfcbx	213	20	enhanced	enhance	VBN
cord-252528-rgnhfcbx	213	21	Ang	Ang	NNP
cord-252528-rgnhfcbx	213	22	II	II	NNP
cord-252528-rgnhfcbx	213	23	level	level	NN
cord-252528-rgnhfcbx	213	24	can	can	MD
cord-252528-rgnhfcbx	213	25	further	far	RBR
cord-252528-rgnhfcbx	213	26	inhibit	inhibit	VB
cord-252528-rgnhfcbx	213	27	the	the	DT
cord-252528-rgnhfcbx	213	28	expression	expression	NN
cord-252528-rgnhfcbx	213	29	of	of	IN
cord-252528-rgnhfcbx	213	30	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	213	31	by	by	IN
cord-252528-rgnhfcbx	213	32	activating	activate	VBG
cord-252528-rgnhfcbx	213	33	mitogen	mitogen	NN
cord-252528-rgnhfcbx	213	34	-	-	HYPH
cord-252528-rgnhfcbx	213	35	activated	activate	VBN
cord-252528-rgnhfcbx	213	36	protein	protein	NN
cord-252528-rgnhfcbx	213	37	kinase	kinase	NN
cord-252528-rgnhfcbx	213	38	1	1	CD
cord-252528-rgnhfcbx	213	39	(	(	-LRB-
cord-252528-rgnhfcbx	213	40	MAPK1	MAPK1	NNP
cord-252528-rgnhfcbx	213	41	)	)	-RRB-
cord-252528-rgnhfcbx	213	42	and	and	CC
cord-252528-rgnhfcbx	213	43	MAPK3	MAPK3	NNP
cord-252528-rgnhfcbx	213	44	,	,	,
cord-252528-rgnhfcbx	213	45	worsening	worsen	VBG
cord-252528-rgnhfcbx	213	46	the	the	DT
cord-252528-rgnhfcbx	213	47	vascular	vascular	JJ
cord-252528-rgnhfcbx	213	48	injury	injury	NN
cord-252528-rgnhfcbx	213	49	and	and	CC
cord-252528-rgnhfcbx	213	50	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	213	51	[	[	-LRB-
cord-252528-rgnhfcbx	213	52	94	94	CD
cord-252528-rgnhfcbx	213	53	]	]	-RRB-
cord-252528-rgnhfcbx	213	54	.	.	.
cord-252528-rgnhfcbx	214	1	Excessive	excessive	JJ
cord-252528-rgnhfcbx	214	2	cytokine	cytokine	NN
cord-252528-rgnhfcbx	214	3	release	release	NN
cord-252528-rgnhfcbx	214	4	in	in	IN
cord-252528-rgnhfcbx	214	5	severe	severe	JJ
cord-252528-rgnhfcbx	214	6	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	214	7	can	can	MD
cord-252528-rgnhfcbx	214	8	be	be	VB
cord-252528-rgnhfcbx	214	9	a	a	DT
cord-252528-rgnhfcbx	214	10	crucial	crucial	JJ
cord-252528-rgnhfcbx	214	11	factor	factor	NN
cord-252528-rgnhfcbx	214	12	contributing	contribute	VBG
cord-252528-rgnhfcbx	214	13	to	to	IN
cord-252528-rgnhfcbx	214	14	the	the	DT
cord-252528-rgnhfcbx	214	15	pro	pro	JJ
cord-252528-rgnhfcbx	214	16	-	-	JJ
cord-252528-rgnhfcbx	214	17	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	214	18	activities	activity	NNS
cord-252528-rgnhfcbx	214	19	related	relate	VBN
cord-252528-rgnhfcbx	214	20	to	to	IN
cord-252528-rgnhfcbx	214	21	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	214	22	down	down	JJ
cord-252528-rgnhfcbx	214	23	-	-	HYPH
cord-252528-rgnhfcbx	214	24	regulation	regulation	NN
cord-252528-rgnhfcbx	215	1	(	(	-LRB-
cord-252528-rgnhfcbx	215	2	Fig	Fig	NNP
cord-252528-rgnhfcbx	215	3	.	.	.
cord-252528-rgnhfcbx	215	4	3	3	CD
cord-252528-rgnhfcbx	215	5	)	)	-RRB-
cord-252528-rgnhfcbx	215	6	.	.	.
cord-252528-rgnhfcbx	216	1	Emerging	emerge	VBG
cord-252528-rgnhfcbx	216	2	amounts	amount	NNS
cord-252528-rgnhfcbx	216	3	of	of	IN
cord-252528-rgnhfcbx	216	4	evidence	evidence	NN
cord-252528-rgnhfcbx	216	5	have	have	VBP
cord-252528-rgnhfcbx	216	6	shown	show	VBN
cord-252528-rgnhfcbx	216	7	the	the	DT
cord-252528-rgnhfcbx	216	8	critical	critical	JJ
cord-252528-rgnhfcbx	216	9	role	role	NN
cord-252528-rgnhfcbx	216	10	of	of	IN
cord-252528-rgnhfcbx	216	11	pro	pro	JJ
cord-252528-rgnhfcbx	216	12	-	-	JJ
cord-252528-rgnhfcbx	216	13	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	216	14	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	216	15	in	in	IN
cord-252528-rgnhfcbx	216	16	Ang	Ang	NNP
cord-252528-rgnhfcbx	216	17	II	II	NNP
cord-252528-rgnhfcbx	216	18	-	-	HYPH
cord-252528-rgnhfcbx	216	19	mediated	mediate	VBN
cord-252528-rgnhfcbx	216	20	vascular	vascular	JJ
cord-252528-rgnhfcbx	216	21	Fig	fig	NN
cord-252528-rgnhfcbx	216	22	.	.	.
cord-252528-rgnhfcbx	217	1	3	3	CD
cord-252528-rgnhfcbx	217	2	Schematic	Schematic	NNP
cord-252528-rgnhfcbx	217	3	diagram	diagram	NN
cord-252528-rgnhfcbx	217	4	showing	show	VBG
cord-252528-rgnhfcbx	217	5	the	the	DT
cord-252528-rgnhfcbx	217	6	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	217	7	by	by	IN
cord-252528-rgnhfcbx	217	8	which	which	WDT
cord-252528-rgnhfcbx	217	9	potential	potential	JJ
cord-252528-rgnhfcbx	217	10	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	217	11	expression	expression	NN
cord-252528-rgnhfcbx	217	12	down	down	IN
cord-252528-rgnhfcbx	217	13	-	-	HYPH
cord-252528-rgnhfcbx	217	14	regulation	regulation	NN
cord-252528-rgnhfcbx	217	15	in	in	IN
cord-252528-rgnhfcbx	217	16	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	217	17	contributes	contribute	VBZ
cord-252528-rgnhfcbx	217	18	to	to	IN
cord-252528-rgnhfcbx	217	19	vascular	vascular	JJ
cord-252528-rgnhfcbx	217	20	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	217	21	and	and	CC
cord-252528-rgnhfcbx	217	22	the	the	DT
cord-252528-rgnhfcbx	217	23	reciprocal	reciprocal	JJ
cord-252528-rgnhfcbx	217	24	promoting	promote	VBG
cord-252528-rgnhfcbx	217	25	relationship	relationship	NN
cord-252528-rgnhfcbx	217	26	between	between	IN
cord-252528-rgnhfcbx	217	27	the	the	DT
cord-252528-rgnhfcbx	217	28	effect	effect	NN
cord-252528-rgnhfcbx	217	29	of	of	IN
cord-252528-rgnhfcbx	217	30	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	217	31	expression	expression	NN
cord-252528-rgnhfcbx	217	32	down	down	IN
cord-252528-rgnhfcbx	217	33	-	-	HYPH
cord-252528-rgnhfcbx	217	34	regulation	regulation	NN
cord-252528-rgnhfcbx	217	35	and	and	CC
cord-252528-rgnhfcbx	217	36	that	that	DT
cord-252528-rgnhfcbx	217	37	of	of	IN
cord-252528-rgnhfcbx	217	38	excessive	excessive	JJ
cord-252528-rgnhfcbx	217	39	cytokine	cytokine	NN
cord-252528-rgnhfcbx	217	40	release	release	NN
cord-252528-rgnhfcbx	217	41	on	on	IN
cord-252528-rgnhfcbx	217	42	vascular	vascular	JJ
cord-252528-rgnhfcbx	217	43	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	217	44	.	.	.
cord-252528-rgnhfcbx	218	1	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	218	2	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	218	3	-	-	HYPH
cord-252528-rgnhfcbx	218	4	converting	convert	VBG
cord-252528-rgnhfcbx	218	5	enzyme	enzyme	NN
cord-252528-rgnhfcbx	218	6	2	2	CD
cord-252528-rgnhfcbx	219	1	,	,	,
cord-252528-rgnhfcbx	219	2	IFN	IFN	NNP
cord-252528-rgnhfcbx	219	3	-	-	HYPH
cord-252528-rgnhfcbx	219	4	γ	γ	NNP
cord-252528-rgnhfcbx	219	5	interferon	interferon	NN
cord-252528-rgnhfcbx	219	6	γ	γ	NN
cord-252528-rgnhfcbx	219	7	,	,	,
cord-252528-rgnhfcbx	219	8	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	219	9	interleukin-6	interleukin-6	NNP
cord-252528-rgnhfcbx	219	10	,	,	,
cord-252528-rgnhfcbx	219	11	PAI-1	PAI-1	NNP
cord-252528-rgnhfcbx	219	12	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	219	13	activator	activator	NN
cord-252528-rgnhfcbx	219	14	inhibitor-1	inhibitor-1	NNP
cord-252528-rgnhfcbx	219	15	,	,	,
cord-252528-rgnhfcbx	219	16	TF	TF	NNP
cord-252528-rgnhfcbx	219	17	tissue	tissue	NN
cord-252528-rgnhfcbx	219	18	factor	factor	NN
cord-252528-rgnhfcbx	219	19	dysfunctions	dysfunction	NNS
cord-252528-rgnhfcbx	219	20	.	.	.
cord-252528-rgnhfcbx	220	1	In	in	IN
cord-252528-rgnhfcbx	220	2	IFN	IFN	NNP
cord-252528-rgnhfcbx	220	3	-	-	HYPH
cord-252528-rgnhfcbx	220	4	γ	γ	NN
cord-252528-rgnhfcbx	220	5	knockout	knockout	NN
cord-252528-rgnhfcbx	220	6	mice	mouse	NNS
cord-252528-rgnhfcbx	220	7	,	,	,
cord-252528-rgnhfcbx	220	8	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	220	9	of	of	IN
cord-252528-rgnhfcbx	220	10	Ang	Ang	NNP
cord-252528-rgnhfcbx	220	11	II	II	NNP
cord-252528-rgnhfcbx	220	12	-	-	HYPH
cord-252528-rgnhfcbx	220	13	mediated	mediate	VBN
cord-252528-rgnhfcbx	220	14	vascular	vascular	JJ
cord-252528-rgnhfcbx	220	15	injury	injury	NN
cord-252528-rgnhfcbx	220	16	are	be	VBP
cord-252528-rgnhfcbx	220	17	attenuated	attenuated	JJ
cord-252528-rgnhfcbx	220	18	.	.	.
cord-252528-rgnhfcbx	221	1	This	this	DT
cord-252528-rgnhfcbx	221	2	attenuation	attenuation	NN
cord-252528-rgnhfcbx	221	3	of	of	IN
cord-252528-rgnhfcbx	221	4	vascular	vascular	JJ
cord-252528-rgnhfcbx	221	5	injury	injury	NN
cord-252528-rgnhfcbx	221	6	is	be	VBZ
cord-252528-rgnhfcbx	221	7	due	due	JJ
cord-252528-rgnhfcbx	221	8	to	to	IN
cord-252528-rgnhfcbx	221	9	decreased	decrease	VBN
cord-252528-rgnhfcbx	221	10	IFN	IFN	NNP
cord-252528-rgnhfcbx	221	11	-	-	HYPH
cord-252528-rgnhfcbx	221	12	γ	γ	NNP
cord-252528-rgnhfcbx	221	13	mediated	mediate	VBD
cord-252528-rgnhfcbx	221	14	nature	nature	NN
cord-252528-rgnhfcbx	221	15	killer	killer	NN
cord-252528-rgnhfcbx	221	16	(	(	-LRB-
cord-252528-rgnhfcbx	221	17	NK	NK	NNP
cord-252528-rgnhfcbx	221	18	)	)	-RRB-
cord-252528-rgnhfcbx	221	19	cell	cell	NN
cord-252528-rgnhfcbx	221	20	and	and	CC
cord-252528-rgnhfcbx	221	21	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	221	22	recruitment	recruitment	NNP
cord-252528-rgnhfcbx	221	23	,	,	,
cord-252528-rgnhfcbx	221	24	and	and	CC
cord-252528-rgnhfcbx	221	25	reduced	reduce	VBN
cord-252528-rgnhfcbx	221	26	mutual	mutual	JJ
cord-252528-rgnhfcbx	221	27	activation	activation	NN
cord-252528-rgnhfcbx	221	28	of	of	IN
cord-252528-rgnhfcbx	221	29	NK	NK	NNP
cord-252528-rgnhfcbx	221	30	cells	cell	NNS
cord-252528-rgnhfcbx	221	31	and	and	CC
cord-252528-rgnhfcbx	221	32	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	221	33	at	at	IN
cord-252528-rgnhfcbx	221	34	the	the	DT
cord-252528-rgnhfcbx	221	35	vessel	vessel	NN
cord-252528-rgnhfcbx	221	36	[	[	-LRB-
cord-252528-rgnhfcbx	221	37	95	95	CD
cord-252528-rgnhfcbx	221	38	]	]	-RRB-
cord-252528-rgnhfcbx	221	39	.	.	.
cord-252528-rgnhfcbx	222	1	In	in	IN
cord-252528-rgnhfcbx	222	2	addition	addition	NN
cord-252528-rgnhfcbx	222	3	,	,	,
cord-252528-rgnhfcbx	222	4	a	a	DT
cord-252528-rgnhfcbx	222	5	recent	recent	JJ
cord-252528-rgnhfcbx	222	6	animal	animal	NN
cord-252528-rgnhfcbx	222	7	study	study	NN
cord-252528-rgnhfcbx	222	8	suggests	suggest	VBZ
cord-252528-rgnhfcbx	222	9	that	that	IN
cord-252528-rgnhfcbx	222	10	Ang	Ang	NNP
cord-252528-rgnhfcbx	222	11	II	II	NNP
cord-252528-rgnhfcbx	222	12	promotes	promote	VBZ
cord-252528-rgnhfcbx	222	13	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	222	14	through	through	IN
cord-252528-rgnhfcbx	222	15	increased	increase	VBN
cord-252528-rgnhfcbx	222	16	platelet	platelet	NN
cord-252528-rgnhfcbx	222	17	activation	activation	NN
cord-252528-rgnhfcbx	222	18	induced	induce	VBN
cord-252528-rgnhfcbx	222	19	by	by	IN
cord-252528-rgnhfcbx	222	20	T	T	NNP
cord-252528-rgnhfcbx	222	21	cell	cell	NN
cord-252528-rgnhfcbx	222	22	-	-	HYPH
cord-252528-rgnhfcbx	222	23	dependent	dependent	JJ
cord-252528-rgnhfcbx	222	24	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	222	25	signaling	signal	VBG
cord-252528-rgnhfcbx	222	26	[	[	-LRB-
cord-252528-rgnhfcbx	222	27	96	96	CD
cord-252528-rgnhfcbx	222	28	]	]	-RRB-
cord-252528-rgnhfcbx	222	29	.	.	.
cord-252528-rgnhfcbx	223	1	Hence	hence	RB
cord-252528-rgnhfcbx	223	2	,	,	,
cord-252528-rgnhfcbx	223	3	the	the	DT
cord-252528-rgnhfcbx	223	4	elevated	elevated	JJ
cord-252528-rgnhfcbx	223	5	serum	serum	NN
cord-252528-rgnhfcbx	223	6	levels	level	NNS
cord-252528-rgnhfcbx	223	7	of	of	IN
cord-252528-rgnhfcbx	223	8	pro	pro	JJ
cord-252528-rgnhfcbx	223	9	-	-	JJ
cord-252528-rgnhfcbx	223	10	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	223	11	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	223	12	in	in	IN
cord-252528-rgnhfcbx	223	13	severe	severe	JJ
cord-252528-rgnhfcbx	223	14	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	223	15	tend	tend	NNS
cord-252528-rgnhfcbx	223	16	to	to	TO
cord-252528-rgnhfcbx	223	17	favor	favor	VB
cord-252528-rgnhfcbx	223	18	the	the	DT
cord-252528-rgnhfcbx	223	19	Ang	Ang	NNP
cord-252528-rgnhfcbx	223	20	IImediated	IImediated	NNP
cord-252528-rgnhfcbx	223	21	vascular	vascular	JJ
cord-252528-rgnhfcbx	223	22	injury	injury	NN
cord-252528-rgnhfcbx	223	23	and	and	CC
cord-252528-rgnhfcbx	223	24	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	223	25	.	.	.
cord-252528-rgnhfcbx	224	1	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	224	2	down	down	NN
cord-252528-rgnhfcbx	224	3	-	-	HYPH
cord-252528-rgnhfcbx	224	4	regulation	regulation	NN
cord-252528-rgnhfcbx	224	5	can	can	MD
cord-252528-rgnhfcbx	224	6	,	,	,
cord-252528-rgnhfcbx	224	7	in	in	IN
cord-252528-rgnhfcbx	224	8	turn	turn	NN
cord-252528-rgnhfcbx	224	9	,	,	,
cord-252528-rgnhfcbx	224	10	lead	lead	VB
cord-252528-rgnhfcbx	224	11	to	to	IN
cord-252528-rgnhfcbx	224	12	enhanced	enhance	VBN
cord-252528-rgnhfcbx	224	13	levels	level	NNS
cord-252528-rgnhfcbx	224	14	of	of	IN
cord-252528-rgnhfcbx	224	15	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	224	16	with	with	IN
cord-252528-rgnhfcbx	224	17	pro	pro	JJ
cord-252528-rgnhfcbx	224	18	-	-	JJ
cord-252528-rgnhfcbx	224	19	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	224	20	activities	activity	NNS
cord-252528-rgnhfcbx	224	21	(	(	-LRB-
cord-252528-rgnhfcbx	224	22	Fig	Fig	NNP
cord-252528-rgnhfcbx	224	23	.	.	.
cord-252528-rgnhfcbx	224	24	3	3	CD
cord-252528-rgnhfcbx	224	25	)	)	-RRB-
cord-252528-rgnhfcbx	224	26	.	.	.
cord-252528-rgnhfcbx	225	1	A	a	DT
cord-252528-rgnhfcbx	225	2	randomized	randomized	JJ
cord-252528-rgnhfcbx	225	3	double	double	JJ
cord-252528-rgnhfcbx	225	4	-	-	HYPH
cord-252528-rgnhfcbx	225	5	blind	blind	JJ
cord-252528-rgnhfcbx	225	6	clinical	clinical	JJ
cord-252528-rgnhfcbx	225	7	study	study	NN
cord-252528-rgnhfcbx	225	8	has	have	VBZ
cord-252528-rgnhfcbx	225	9	shown	show	VBN
cord-252528-rgnhfcbx	225	10	that	that	IN
cord-252528-rgnhfcbx	225	11	in	in	IN
cord-252528-rgnhfcbx	225	12	patients	patient	NNS
cord-252528-rgnhfcbx	225	13	with	with	IN
cord-252528-rgnhfcbx	225	14	coronary	coronary	JJ
cord-252528-rgnhfcbx	225	15	artery	artery	NN
cord-252528-rgnhfcbx	225	16	disease	disease	NN
cord-252528-rgnhfcbx	225	17	,	,	,
cord-252528-rgnhfcbx	225	18	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	225	19	/	/	SYM
cord-252528-rgnhfcbx	225	20	ARB	ARB	NNP
cord-252528-rgnhfcbx	225	21	treatment	treatment	NN
cord-252528-rgnhfcbx	225	22	elevates	elevate	VBZ
cord-252528-rgnhfcbx	225	23	the	the	DT
cord-252528-rgnhfcbx	225	24	serum	serum	NN
cord-252528-rgnhfcbx	225	25	level	level	NN
cord-252528-rgnhfcbx	225	26	of	of	IN
cord-252528-rgnhfcbx	225	27	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	225	28	,	,	,
cord-252528-rgnhfcbx	225	29	but	but	CC
cord-252528-rgnhfcbx	225	30	reduce	reduce	VB
cord-252528-rgnhfcbx	225	31	the	the	DT
cord-252528-rgnhfcbx	225	32	serum	serum	NN
cord-252528-rgnhfcbx	225	33	level	level	NN
cord-252528-rgnhfcbx	225	34	of	of	IN
cord-252528-rgnhfcbx	225	35	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	225	36	,	,	,
cord-252528-rgnhfcbx	225	37	thereby	thereby	RB
cord-252528-rgnhfcbx	225	38	decreasing	decrease	VBG
cord-252528-rgnhfcbx	225	39	the	the	DT
cord-252528-rgnhfcbx	225	40	thrombin	thrombin	NN
cord-252528-rgnhfcbx	225	41	stimulated	stimulate	VBN
cord-252528-rgnhfcbx	225	42	platelet	platelet	NN
cord-252528-rgnhfcbx	225	43	aggregation	aggregation	NN
cord-252528-rgnhfcbx	225	44	in	in	IN
cord-252528-rgnhfcbx	225	45	the	the	DT
cord-252528-rgnhfcbx	225	46	plasma	plasma	NN
cord-252528-rgnhfcbx	225	47	[	[	-LRB-
cord-252528-rgnhfcbx	225	48	97	97	CD
cord-252528-rgnhfcbx	225	49	]	]	-RRB-
cord-252528-rgnhfcbx	225	50	.	.	.
cord-252528-rgnhfcbx	226	1	Thus	thus	RB
cord-252528-rgnhfcbx	226	2	,	,	,
cord-252528-rgnhfcbx	226	3	in	in	IN
cord-252528-rgnhfcbx	226	4	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	226	5	,	,	,
cord-252528-rgnhfcbx	226	6	the	the	DT
cord-252528-rgnhfcbx	226	7	possible	possible	JJ
cord-252528-rgnhfcbx	226	8	down	down	RB
cord-252528-rgnhfcbx	226	9	-	-	HYPH
cord-252528-rgnhfcbx	226	10	regulated	regulate	VBN
cord-252528-rgnhfcbx	226	11	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	226	12	activity	activity	NN
cord-252528-rgnhfcbx	226	13	can	can	MD
cord-252528-rgnhfcbx	226	14	leave	leave	VB
cord-252528-rgnhfcbx	226	15	the	the	DT
cord-252528-rgnhfcbx	226	16	activity	activity	NN
cord-252528-rgnhfcbx	226	17	of	of	IN
cord-252528-rgnhfcbx	226	18	ACE	ACE	NNP
cord-252528-rgnhfcbx	226	19	/	/	SYM
cord-252528-rgnhfcbx	226	20	Ang	Ang	NNP
cord-252528-rgnhfcbx	226	21	II	II	NNP
cord-252528-rgnhfcbx	226	22	/	/	SYM
cord-252528-rgnhfcbx	226	23	AT1	at1	NN
cord-252528-rgnhfcbx	226	24	axis	axis	NN
cord-252528-rgnhfcbx	226	25	uncontrolled	uncontrolled	JJ
cord-252528-rgnhfcbx	226	26	,	,	,
cord-252528-rgnhfcbx	226	27	resulting	result	VBG
cord-252528-rgnhfcbx	226	28	in	in	IN
cord-252528-rgnhfcbx	226	29	excessive	excessive	JJ
cord-252528-rgnhfcbx	226	30	inflammation	inflammation	NN
cord-252528-rgnhfcbx	226	31	characterized	characterize	VBN
cord-252528-rgnhfcbx	226	32	by	by	IN
cord-252528-rgnhfcbx	226	33	increased	increase	VBN
cord-252528-rgnhfcbx	226	34	serum	serum	NN
cord-252528-rgnhfcbx	226	35	levels	level	NNS
cord-252528-rgnhfcbx	226	36	of	of	IN
cord-252528-rgnhfcbx	226	37	pro	pro	JJ
cord-252528-rgnhfcbx	226	38	-	-	JJ
cord-252528-rgnhfcbx	226	39	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	226	40	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	226	41	but	but	CC
cord-252528-rgnhfcbx	226	42	decreased	decrease	VBD
cord-252528-rgnhfcbx	226	43	serum	serum	NN
cord-252528-rgnhfcbx	226	44	levels	level	NNS
cord-252528-rgnhfcbx	226	45	of	of	IN
cord-252528-rgnhfcbx	226	46	antithrombotic	antithrombotic	JJ
cord-252528-rgnhfcbx	226	47	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	226	48	,	,	,
cord-252528-rgnhfcbx	226	49	contributing	contribute	VBG
cord-252528-rgnhfcbx	226	50	to	to	IN
cord-252528-rgnhfcbx	226	51	vascular	vascular	JJ
cord-252528-rgnhfcbx	226	52	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	226	53	.	.	.
cord-252528-rgnhfcbx	227	1	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	227	2	/	/	SYM
cord-252528-rgnhfcbx	227	3	ARB	ARB	NNP
cord-252528-rgnhfcbx	227	4	has	have	VBZ
cord-252528-rgnhfcbx	227	5	been	be	VBN
cord-252528-rgnhfcbx	227	6	essential	essential	JJ
cord-252528-rgnhfcbx	227	7	for	for	IN
cord-252528-rgnhfcbx	227	8	treating	treat	VBG
cord-252528-rgnhfcbx	227	9	hypertension	hypertension	NN
cord-252528-rgnhfcbx	227	10	and	and	CC
cord-252528-rgnhfcbx	227	11	heart	heart	NN
cord-252528-rgnhfcbx	227	12	failure	failure	NN
cord-252528-rgnhfcbx	227	13	,	,	,
cord-252528-rgnhfcbx	227	14	but	but	CC
cord-252528-rgnhfcbx	227	15	the	the	DT
cord-252528-rgnhfcbx	227	16	use	use	NN
cord-252528-rgnhfcbx	227	17	of	of	IN
cord-252528-rgnhfcbx	227	18	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	227	19	/	/	SYM
cord-252528-rgnhfcbx	227	20	ARB	ARB	NNP
cord-252528-rgnhfcbx	227	21	during	during	IN
cord-252528-rgnhfcbx	227	22	the	the	DT
cord-252528-rgnhfcbx	227	23	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	227	24	pandemic	pandemic	NN
cord-252528-rgnhfcbx	227	25	was	be	VBD
cord-252528-rgnhfcbx	227	26	concerned	concerned	JJ
cord-252528-rgnhfcbx	227	27	because	because	IN
cord-252528-rgnhfcbx	227	28	of	of	IN
cord-252528-rgnhfcbx	227	29	the	the	DT
cord-252528-rgnhfcbx	227	30	potential	potential	JJ
cord-252528-rgnhfcbx	227	31	risk	risk	NN
cord-252528-rgnhfcbx	227	32	of	of	IN
cord-252528-rgnhfcbx	227	33	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	227	34	/	/	SYM
cord-252528-rgnhfcbx	227	35	ARB	ARB	NNP
cord-252528-rgnhfcbx	227	36	in	in	IN
cord-252528-rgnhfcbx	227	37	enhancing	enhance	VBG
cord-252528-rgnhfcbx	227	38	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	227	39	expression	expression	NN
cord-252528-rgnhfcbx	227	40	,	,	,
cord-252528-rgnhfcbx	227	41	which	which	WDT
cord-252528-rgnhfcbx	227	42	may	may	MD
cord-252528-rgnhfcbx	227	43	increase	increase	VB
cord-252528-rgnhfcbx	227	44	the	the	DT
cord-252528-rgnhfcbx	227	45	chance	chance	NN
cord-252528-rgnhfcbx	227	46	or	or	CC
cord-252528-rgnhfcbx	227	47	severity	severity	NN
cord-252528-rgnhfcbx	227	48	of	of	IN
cord-252528-rgnhfcbx	227	49	infection	infection	NN
cord-252528-rgnhfcbx	227	50	.	.	.
cord-252528-rgnhfcbx	228	1	However	however	RB
cord-252528-rgnhfcbx	228	2	,	,	,
cord-252528-rgnhfcbx	228	3	most	most	JJS
cord-252528-rgnhfcbx	228	4	of	of	IN
cord-252528-rgnhfcbx	228	5	recent	recent	JJ
cord-252528-rgnhfcbx	228	6	clinical	clinical	JJ
cord-252528-rgnhfcbx	228	7	studies	study	NNS
cord-252528-rgnhfcbx	228	8	do	do	VBP
cord-252528-rgnhfcbx	228	9	not	not	RB
cord-252528-rgnhfcbx	228	10	indicate	indicate	VB
cord-252528-rgnhfcbx	228	11	an	an	DT
cord-252528-rgnhfcbx	228	12	association	association	NN
cord-252528-rgnhfcbx	228	13	between	between	IN
cord-252528-rgnhfcbx	228	14	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	228	15	/	/	SYM
cord-252528-rgnhfcbx	228	16	ARB	ARB	NNP
cord-252528-rgnhfcbx	228	17	treatment	treatment	NN
cord-252528-rgnhfcbx	228	18	and	and	CC
cord-252528-rgnhfcbx	228	19	a	a	DT
cord-252528-rgnhfcbx	228	20	higher	high	JJR
cord-252528-rgnhfcbx	228	21	risk	risk	NN
cord-252528-rgnhfcbx	228	22	of	of	IN
cord-252528-rgnhfcbx	228	23	SARS	SARS	NNP
cord-252528-rgnhfcbx	228	24	-	-	HYPH
cord-252528-rgnhfcbx	228	25	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	228	26	infection	infection	NN
cord-252528-rgnhfcbx	228	27	.	.	.
cord-252528-rgnhfcbx	229	1	A	a	DT
cord-252528-rgnhfcbx	229	2	meta	meta	NN
cord-252528-rgnhfcbx	229	3	-	-	HYPH
cord-252528-rgnhfcbx	229	4	analysis	analysis	NN
cord-252528-rgnhfcbx	229	5	on	on	IN
cord-252528-rgnhfcbx	229	6	19,000	19,000	CD
cord-252528-rgnhfcbx	229	7	cases	case	NNS
cord-252528-rgnhfcbx	229	8	of	of	IN
cord-252528-rgnhfcbx	229	9	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	229	10	suggests	suggest	VBZ
cord-252528-rgnhfcbx	229	11	that	that	IN
cord-252528-rgnhfcbx	229	12	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	229	13	/	/	SYM
cord-252528-rgnhfcbx	229	14	ARB	ARB	NNP
cord-252528-rgnhfcbx	229	15	does	do	VBZ
cord-252528-rgnhfcbx	229	16	not	not	RB
cord-252528-rgnhfcbx	229	17	increase	increase	VB
cord-252528-rgnhfcbx	229	18	the	the	DT
cord-252528-rgnhfcbx	229	19	risk	risk	NN
cord-252528-rgnhfcbx	229	20	of	of	IN
cord-252528-rgnhfcbx	229	21	SARS	SARS	NNP
cord-252528-rgnhfcbx	229	22	-	-	HYPH
cord-252528-rgnhfcbx	229	23	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	229	24	infection	infection	NN
cord-252528-rgnhfcbx	229	25	and	and	CC
cord-252528-rgnhfcbx	229	26	the	the	DT
cord-252528-rgnhfcbx	229	27	disease	disease	NN
cord-252528-rgnhfcbx	229	28	transition	transition	NN
cord-252528-rgnhfcbx	229	29	from	from	IN
cord-252528-rgnhfcbx	229	30	mild	mild	JJ
cord-252528-rgnhfcbx	229	31	to	to	IN
cord-252528-rgnhfcbx	229	32	severe	severe	JJ
cord-252528-rgnhfcbx	229	33	,	,	,
cord-252528-rgnhfcbx	229	34	and	and	CC
cord-252528-rgnhfcbx	229	35	that	that	IN
cord-252528-rgnhfcbx	229	36	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	229	37	/	/	SYM
cord-252528-rgnhfcbx	229	38	ARB	ARB	NNP
cord-252528-rgnhfcbx	229	39	treatment	treatment	NN
cord-252528-rgnhfcbx	229	40	reduces	reduce	VBZ
cord-252528-rgnhfcbx	229	41	the	the	DT
cord-252528-rgnhfcbx	229	42	incidence	incidence	NN
cord-252528-rgnhfcbx	229	43	of	of	IN
cord-252528-rgnhfcbx	229	44	mortality	mortality	NN
cord-252528-rgnhfcbx	229	45	compared	compare	VBN
cord-252528-rgnhfcbx	229	46	to	to	IN
cord-252528-rgnhfcbx	229	47	other	other	JJ
cord-252528-rgnhfcbx	229	48	anti	anti	JJ
cord-252528-rgnhfcbx	229	49	-	-	JJ
cord-252528-rgnhfcbx	229	50	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	229	51	agents	agent	NNS
cord-252528-rgnhfcbx	229	52	in	in	IN
cord-252528-rgnhfcbx	229	53	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	229	54	patients	patient	NNS
cord-252528-rgnhfcbx	229	55	with	with	IN
cord-252528-rgnhfcbx	229	56	hypertension	hypertension	NN
cord-252528-rgnhfcbx	229	57	[	[	-LRB-
cord-252528-rgnhfcbx	229	58	98	98	CD
cord-252528-rgnhfcbx	229	59	]	]	-RRB-
cord-252528-rgnhfcbx	229	60	.	.	.
cord-252528-rgnhfcbx	230	1	Moreover	moreover	RB
cord-252528-rgnhfcbx	230	2	,	,	,
cord-252528-rgnhfcbx	230	3	in	in	IN
cord-252528-rgnhfcbx	230	4	a	a	DT
cord-252528-rgnhfcbx	230	5	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	230	6	analysis	analysis	NN
cord-252528-rgnhfcbx	230	7	of	of	IN
cord-252528-rgnhfcbx	230	8	1128	1128	CD
cord-252528-rgnhfcbx	230	9	adult	adult	NN
cord-252528-rgnhfcbx	230	10	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	230	11	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	230	12	patients	patient	NNS
cord-252528-rgnhfcbx	230	13	,	,	,
cord-252528-rgnhfcbx	230	14	compared	compare	VBN
cord-252528-rgnhfcbx	230	15	to	to	IN
cord-252528-rgnhfcbx	230	16	patients	patient	NNS
cord-252528-rgnhfcbx	230	17	not	not	RB
cord-252528-rgnhfcbx	230	18	taking	take	VBG
cord-252528-rgnhfcbx	230	19	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	230	20	/	/	SYM
cord-252528-rgnhfcbx	230	21	ARB	ARB	NNP
cord-252528-rgnhfcbx	230	22	or	or	CC
cord-252528-rgnhfcbx	230	23	taking	take	VBG
cord-252528-rgnhfcbx	230	24	other	other	JJ
cord-252528-rgnhfcbx	230	25	anti	anti	JJ
cord-252528-rgnhfcbx	230	26	-	-	JJ
cord-252528-rgnhfcbx	230	27	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	230	28	drugs	drug	NNS
cord-252528-rgnhfcbx	230	29	,	,	,
cord-252528-rgnhfcbx	230	30	those	those	DT
cord-252528-rgnhfcbx	230	31	taking	take	VBG
cord-252528-rgnhfcbx	230	32	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	230	33	/	/	SYM
cord-252528-rgnhfcbx	230	34	ARB	ARB	NNP
cord-252528-rgnhfcbx	230	35	are	be	VBP
cord-252528-rgnhfcbx	230	36	associated	associate	VBN
cord-252528-rgnhfcbx	230	37	with	with	IN
cord-252528-rgnhfcbx	230	38	a	a	DT
cord-252528-rgnhfcbx	230	39	lower	low	JJR
cord-252528-rgnhfcbx	230	40	risk	risk	NN
cord-252528-rgnhfcbx	230	41	of	of	IN
cord-252528-rgnhfcbx	230	42	DIC	DIC	NNP
cord-252528-rgnhfcbx	230	43	and	and	CC
cord-252528-rgnhfcbx	230	44	mortality	mortality	NN
cord-252528-rgnhfcbx	230	45	[	[	-LRB-
cord-252528-rgnhfcbx	230	46	99	99	CD
cord-252528-rgnhfcbx	230	47	]	]	-RRB-
cord-252528-rgnhfcbx	230	48	.	.	.
cord-252528-rgnhfcbx	231	1	As	as	IN
cord-252528-rgnhfcbx	231	2	described	describe	VBN
cord-252528-rgnhfcbx	231	3	at	at	IN
cord-252528-rgnhfcbx	231	4	the	the	DT
cord-252528-rgnhfcbx	231	5	end	end	NN
cord-252528-rgnhfcbx	231	6	of	of	IN
cord-252528-rgnhfcbx	231	7	the	the	DT
cord-252528-rgnhfcbx	231	8	previous	previous	JJ
cord-252528-rgnhfcbx	231	9	section	section	NN
cord-252528-rgnhfcbx	231	10	,	,	,
cord-252528-rgnhfcbx	231	11	ACEI/	ACEI/	NNP
cord-252528-rgnhfcbx	231	12	ARB	ARB	NNP
cord-252528-rgnhfcbx	231	13	can	can	MD
cord-252528-rgnhfcbx	231	14	lower	lower	VB
cord-252528-rgnhfcbx	231	15	the	the	DT
cord-252528-rgnhfcbx	231	16	risk	risk	NN
cord-252528-rgnhfcbx	231	17	of	of	IN
cord-252528-rgnhfcbx	231	18	hypercoagulability	hypercoagulability	NN
cord-252528-rgnhfcbx	231	19	by	by	IN
cord-252528-rgnhfcbx	231	20	controlling	control	VBG
cord-252528-rgnhfcbx	231	21	systemic	systemic	JJ
cord-252528-rgnhfcbx	231	22	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	231	23	.	.	.
cord-252528-rgnhfcbx	232	1	Besides	besides	RB
cord-252528-rgnhfcbx	232	2	,	,	,
cord-252528-rgnhfcbx	232	3	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	232	4	/	/	SYM
cord-252528-rgnhfcbx	232	5	ARB	ARB	NNP
cord-252528-rgnhfcbx	232	6	can	can	MD
cord-252528-rgnhfcbx	232	7	also	also	RB
cord-252528-rgnhfcbx	232	8	reduce	reduce	VB
cord-252528-rgnhfcbx	232	9	vascular	vascular	JJ
cord-252528-rgnhfcbx	232	10	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	232	11	,	,	,
cord-252528-rgnhfcbx	232	12	preventing	prevent	VBG
cord-252528-rgnhfcbx	232	13	vascular	vascular	JJ
cord-252528-rgnhfcbx	232	14	injuries	injury	NNS
cord-252528-rgnhfcbx	232	15	and	and	CC
cord-252528-rgnhfcbx	232	16	platelet	platelet	NN
cord-252528-rgnhfcbx	232	17	activations	activation	NNS
cord-252528-rgnhfcbx	232	18	(	(	-LRB-
cord-252528-rgnhfcbx	232	19	Fig	Fig	NNP
cord-252528-rgnhfcbx	232	20	.	.	.
cord-252528-rgnhfcbx	232	21	3	3	CD
cord-252528-rgnhfcbx	232	22	)	)	-RRB-
cord-252528-rgnhfcbx	233	1	[	[	-LRB-
cord-252528-rgnhfcbx	233	2	97	97	CD
cord-252528-rgnhfcbx	233	3	]	]	-RRB-
cord-252528-rgnhfcbx	233	4	.	.	.
cord-252528-rgnhfcbx	234	1	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	234	2	can	can	MD
cord-252528-rgnhfcbx	234	3	prevent	prevent	VB
cord-252528-rgnhfcbx	234	4	vascular	vascular	JJ
cord-252528-rgnhfcbx	234	5	inflammation	inflammation	NN
cord-252528-rgnhfcbx	234	6	by	by	IN
cord-252528-rgnhfcbx	234	7	reducing	reduce	VBG
cord-252528-rgnhfcbx	234	8	the	the	DT
cord-252528-rgnhfcbx	234	9	activity	activity	NN
cord-252528-rgnhfcbx	234	10	of	of	IN
cord-252528-rgnhfcbx	234	11	nuclear	nuclear	JJ
cord-252528-rgnhfcbx	234	12	factor	factor	NN
cord-252528-rgnhfcbx	234	13	kappa	kappa	NN
cord-252528-rgnhfcbx	234	14	-	-	HYPH
cord-252528-rgnhfcbx	234	15	B	B	NNP
cord-252528-rgnhfcbx	234	16	(	(	-LRB-
cord-252528-rgnhfcbx	234	17	NF	nf	NN
cord-252528-rgnhfcbx	234	18	-	-	HYPH
cord-252528-rgnhfcbx	234	19	κB	κB	NNP
cord-252528-rgnhfcbx	234	20	)	)	-RRB-
cord-252528-rgnhfcbx	234	21	in	in	IN
cord-252528-rgnhfcbx	234	22	vascular	vascular	JJ
cord-252528-rgnhfcbx	234	23	cells	cell	NNS
cord-252528-rgnhfcbx	234	24	and	and	CC
cord-252528-rgnhfcbx	234	25	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	234	26	[	[	-LRB-
cord-252528-rgnhfcbx	234	27	100	100	CD
cord-252528-rgnhfcbx	234	28	,	,	,
cord-252528-rgnhfcbx	234	29	101	101	CD
cord-252528-rgnhfcbx	234	30	]	]	-RRB-
cord-252528-rgnhfcbx	234	31	.	.	.
cord-252528-rgnhfcbx	235	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	235	2	,	,	,
cord-252528-rgnhfcbx	235	3	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	235	4	reduces	reduce	VBZ
cord-252528-rgnhfcbx	235	5	levels	level	NNS
cord-252528-rgnhfcbx	235	6	of	of	IN
cord-252528-rgnhfcbx	235	7	pro	pro	JJ
cord-252528-rgnhfcbx	235	8	-	-	JJ
cord-252528-rgnhfcbx	235	9	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	235	10	cytokine	cytokine	NN
cord-252528-rgnhfcbx	235	11	expressions	expression	NNS
cord-252528-rgnhfcbx	235	12	in	in	IN
cord-252528-rgnhfcbx	235	13	the	the	DT
cord-252528-rgnhfcbx	235	14	aorta	aorta	NN
cord-252528-rgnhfcbx	235	15	in	in	IN
cord-252528-rgnhfcbx	235	16	patients	patient	NNS
cord-252528-rgnhfcbx	235	17	with	with	IN
cord-252528-rgnhfcbx	235	18	abdominal	abdominal	JJ
cord-252528-rgnhfcbx	235	19	aortic	aortic	JJ
cord-252528-rgnhfcbx	235	20	aneurysm	aneurysm	NN
cord-252528-rgnhfcbx	235	21	,	,	,
cord-252528-rgnhfcbx	235	22	indicating	indicate	VBG
cord-252528-rgnhfcbx	235	23	the	the	DT
cord-252528-rgnhfcbx	235	24	ability	ability	NN
cord-252528-rgnhfcbx	235	25	of	of	IN
cord-252528-rgnhfcbx	235	26	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	235	27	to	to	TO
cord-252528-rgnhfcbx	235	28	reduce	reduce	VB
cord-252528-rgnhfcbx	235	29	vascular	vascular	JJ
cord-252528-rgnhfcbx	235	30	inflammation	inflammation	NN
cord-252528-rgnhfcbx	235	31	[	[	-LRB-
cord-252528-rgnhfcbx	235	32	102	102	CD
cord-252528-rgnhfcbx	235	33	]	]	-RRB-
cord-252528-rgnhfcbx	235	34	.	.	.
cord-252528-rgnhfcbx	236	1	Additionally	additionally	RB
cord-252528-rgnhfcbx	236	2	,	,	,
cord-252528-rgnhfcbx	236	3	ARB	ARB	NNP
cord-252528-rgnhfcbx	236	4	can	can	MD
cord-252528-rgnhfcbx	236	5	normalize	normalize	VB
cord-252528-rgnhfcbx	236	6	the	the	DT
cord-252528-rgnhfcbx	236	7	vascular	vascular	JJ
cord-252528-rgnhfcbx	236	8	inflammation	inflammation	NN
cord-252528-rgnhfcbx	236	9	and	and	CC
cord-252528-rgnhfcbx	236	10	vascular	vascular	JJ
cord-252528-rgnhfcbx	236	11	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	236	12	caused	cause	VBN
cord-252528-rgnhfcbx	236	13	by	by	IN
cord-252528-rgnhfcbx	236	14	Ang	Ang	NNP
cord-252528-rgnhfcbx	236	15	II	II	NNP
cord-252528-rgnhfcbx	236	16	[	[	-LRB-
cord-252528-rgnhfcbx	236	17	103	103	CD
cord-252528-rgnhfcbx	236	18	]	]	-RRB-
cord-252528-rgnhfcbx	236	19	.	.	.
cord-252528-rgnhfcbx	237	1	Antagonization	Antagonization	NNP
cord-252528-rgnhfcbx	237	2	of	of	IN
cord-252528-rgnhfcbx	237	3	AT1	AT1	NNP
cord-252528-rgnhfcbx	237	4	by	by	IN
cord-252528-rgnhfcbx	237	5	ARB	ARB	NNP
cord-252528-rgnhfcbx	237	6	can	can	MD
cord-252528-rgnhfcbx	237	7	result	result	VB
cord-252528-rgnhfcbx	237	8	in	in	IN
cord-252528-rgnhfcbx	237	9	increased	increase	VBN
cord-252528-rgnhfcbx	237	10	Ang	Ang	NNP
cord-252528-rgnhfcbx	237	11	II	II	NNP
cord-252528-rgnhfcbx	237	12	-	-	HYPH
cord-252528-rgnhfcbx	237	13	induced	induce	VBN
cord-252528-rgnhfcbx	237	14	EC	EC	NNP
cord-252528-rgnhfcbx	237	15	AT2	at2	NN
cord-252528-rgnhfcbx	237	16	activation	activation	NN
cord-252528-rgnhfcbx	237	17	,	,	,
cord-252528-rgnhfcbx	237	18	which	which	WDT
cord-252528-rgnhfcbx	237	19	can	can	MD
cord-252528-rgnhfcbx	237	20	promote	promote	VB
cord-252528-rgnhfcbx	237	21	NO	no	DT
cord-252528-rgnhfcbx	237	22	production	production	NN
cord-252528-rgnhfcbx	237	23	,	,	,
cord-252528-rgnhfcbx	237	24	preventing	prevent	VBG
cord-252528-rgnhfcbx	237	25	vascular	vascular	JJ
cord-252528-rgnhfcbx	237	26	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	237	27	[	[	-LRB-
cord-252528-rgnhfcbx	237	28	104	104	CD
cord-252528-rgnhfcbx	237	29	,	,	,
cord-252528-rgnhfcbx	237	30	105	105	CD
cord-252528-rgnhfcbx	237	31	]	]	-RRB-
cord-252528-rgnhfcbx	237	32	.	.	.
cord-252528-rgnhfcbx	238	1	Hence	hence	RB
cord-252528-rgnhfcbx	238	2	,	,	,
cord-252528-rgnhfcbx	238	3	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	238	4	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	238	5	patients	patient	NNS
cord-252528-rgnhfcbx	238	6	can	can	MD
cord-252528-rgnhfcbx	238	7	benefit	benefit	VB
cord-252528-rgnhfcbx	238	8	from	from	IN
cord-252528-rgnhfcbx	238	9	the	the	DT
cord-252528-rgnhfcbx	238	10	vasoprotective	vasoprotective	JJ
cord-252528-rgnhfcbx	238	11	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	238	12	of	of	IN
cord-252528-rgnhfcbx	238	13	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	238	14	/	/	SYM
cord-252528-rgnhfcbx	238	15	ARB	ARB	NNP
cord-252528-rgnhfcbx	238	16	.	.	.
cord-252528-rgnhfcbx	239	1	Better	well	JJR
cord-252528-rgnhfcbx	239	2	clinical	clinical	JJ
cord-252528-rgnhfcbx	239	3	outcomes	outcome	NNS
cord-252528-rgnhfcbx	239	4	of	of	IN
cord-252528-rgnhfcbx	239	5	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	239	6	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	239	7	patients	patient	NNS
cord-252528-rgnhfcbx	239	8	who	who	WP
cord-252528-rgnhfcbx	239	9	received	receive	VBD
cord-252528-rgnhfcbx	239	10	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	239	11	/	/	SYM
cord-252528-rgnhfcbx	239	12	ARB	ARB	NNP
cord-252528-rgnhfcbx	239	13	in	in	IN
cord-252528-rgnhfcbx	239	14	recent	recent	JJ
cord-252528-rgnhfcbx	239	15	clinical	clinical	JJ
cord-252528-rgnhfcbx	239	16	studies	study	NNS
cord-252528-rgnhfcbx	239	17	can	can	MD
cord-252528-rgnhfcbx	239	18	be	be	VB
cord-252528-rgnhfcbx	239	19	in	in	IN
cord-252528-rgnhfcbx	239	20	part	part	NN
cord-252528-rgnhfcbx	239	21	attributed	attribute	VBN
cord-252528-rgnhfcbx	239	22	to	to	IN
cord-252528-rgnhfcbx	239	23	the	the	DT
cord-252528-rgnhfcbx	239	24	capability	capability	NN
cord-252528-rgnhfcbx	239	25	of	of	IN
cord-252528-rgnhfcbx	239	26	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	239	27	/	/	SYM
cord-252528-rgnhfcbx	239	28	ARB	ARB	NNP
cord-252528-rgnhfcbx	239	29	to	to	TO
cord-252528-rgnhfcbx	239	30	prevent	prevent	VB
cord-252528-rgnhfcbx	239	31	a	a	DT
cord-252528-rgnhfcbx	239	32	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	239	33	state	state	NN
cord-252528-rgnhfcbx	239	34	.	.	.
cord-252528-rgnhfcbx	240	1	The	the	DT
cord-252528-rgnhfcbx	240	2	severity	severity	NN
cord-252528-rgnhfcbx	240	3	of	of	IN
cord-252528-rgnhfcbx	240	4	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	240	5	is	be	VBZ
cord-252528-rgnhfcbx	240	6	associated	associate	VBN
cord-252528-rgnhfcbx	240	7	with	with	IN
cord-252528-rgnhfcbx	240	8	both	both	DT
cord-252528-rgnhfcbx	240	9	excessive	excessive	JJ
cord-252528-rgnhfcbx	240	10	cytokine	cytokine	NN
cord-252528-rgnhfcbx	240	11	release	release	NN
cord-252528-rgnhfcbx	240	12	and	and	CC
cord-252528-rgnhfcbx	240	13	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	240	14	state	state	NN
cord-252528-rgnhfcbx	240	15	.	.	.
cord-252528-rgnhfcbx	241	1	Age	Age	NNP
cord-252528-rgnhfcbx	241	2	and	and	CC
cord-252528-rgnhfcbx	241	3	HLA	HLA	NNP
cord-252528-rgnhfcbx	241	4	polymorphisms	polymorphism	NNS
cord-252528-rgnhfcbx	241	5	could	could	MD
cord-252528-rgnhfcbx	241	6	be	be	VB
cord-252528-rgnhfcbx	241	7	factors	factor	NNS
cord-252528-rgnhfcbx	241	8	that	that	WDT
cord-252528-rgnhfcbx	241	9	determine	determine	VBP
cord-252528-rgnhfcbx	241	10	the	the	DT
cord-252528-rgnhfcbx	241	11	propensity	propensity	NN
cord-252528-rgnhfcbx	241	12	to	to	TO
cord-252528-rgnhfcbx	241	13	develop	develop	VB
cord-252528-rgnhfcbx	241	14	the	the	DT
cord-252528-rgnhfcbx	241	15	over	over	RB
cord-252528-rgnhfcbx	241	16	-	-	HYPH
cord-252528-rgnhfcbx	241	17	activated	activate	VBN
cord-252528-rgnhfcbx	241	18	inflammations	inflammation	NNS
cord-252528-rgnhfcbx	241	19	in	in	IN
cord-252528-rgnhfcbx	241	20	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	241	21	.	.	.
cord-252528-rgnhfcbx	242	1	In	in	IN
cord-252528-rgnhfcbx	242	2	severe	severe	JJ
cord-252528-rgnhfcbx	242	3	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	242	4	patients	patient	NNS
cord-252528-rgnhfcbx	242	5	,	,	,
cord-252528-rgnhfcbx	242	6	the	the	DT
cord-252528-rgnhfcbx	242	7	excessive	excessive	JJ
cord-252528-rgnhfcbx	242	8	release	release	NN
cord-252528-rgnhfcbx	242	9	of	of	IN
cord-252528-rgnhfcbx	242	10	pro	pro	JJ
cord-252528-rgnhfcbx	242	11	-	-	JJ
cord-252528-rgnhfcbx	242	12	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	242	13	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	242	14	,	,	,
cord-252528-rgnhfcbx	242	15	including	include	VBG
cord-252528-rgnhfcbx	242	16	IL-2	il-2	NN
cord-252528-rgnhfcbx	242	17	,	,	,
cord-252528-rgnhfcbx	242	18	IFNγ	IFNγ	NNS
cord-252528-rgnhfcbx	242	19	,	,	,
cord-252528-rgnhfcbx	242	20	and	and	CC
cord-252528-rgnhfcbx	242	21	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	242	22	,	,	,
cord-252528-rgnhfcbx	242	23	has	have	VBZ
cord-252528-rgnhfcbx	242	24	been	be	VBN
cord-252528-rgnhfcbx	242	25	consistently	consistently	RB
cord-252528-rgnhfcbx	242	26	shown	show	VBN
cord-252528-rgnhfcbx	242	27	in	in	IN
cord-252528-rgnhfcbx	242	28	recent	recent	JJ
cord-252528-rgnhfcbx	242	29	retrospective	retrospective	JJ
cord-252528-rgnhfcbx	242	30	clinical	clinical	JJ
cord-252528-rgnhfcbx	242	31	studies	study	NNS
cord-252528-rgnhfcbx	242	32	.	.	.
cord-252528-rgnhfcbx	243	1	Abundant	abundant	JJ
cord-252528-rgnhfcbx	243	2	pieces	piece	NNS
cord-252528-rgnhfcbx	243	3	of	of	IN
cord-252528-rgnhfcbx	243	4	evidence	evidence	NN
cord-252528-rgnhfcbx	243	5	have	have	VBP
cord-252528-rgnhfcbx	243	6	indicated	indicate	VBN
cord-252528-rgnhfcbx	243	7	the	the	DT
cord-252528-rgnhfcbx	243	8	role	role	NN
cord-252528-rgnhfcbx	243	9	of	of	IN
cord-252528-rgnhfcbx	243	10	these	these	DT
cord-252528-rgnhfcbx	243	11	pro	pro	JJ
cord-252528-rgnhfcbx	243	12	-	-	JJ
cord-252528-rgnhfcbx	243	13	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	243	14	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	243	15	in	in	IN
cord-252528-rgnhfcbx	243	16	promoting	promote	VBG
cord-252528-rgnhfcbx	243	17	a	a	DT
cord-252528-rgnhfcbx	243	18	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	243	19	state	state	NN
cord-252528-rgnhfcbx	243	20	and	and	CC
cord-252528-rgnhfcbx	243	21	,	,	,
cord-252528-rgnhfcbx	243	22	therefore	therefore	RB
cord-252528-rgnhfcbx	243	23	,	,	,
cord-252528-rgnhfcbx	243	24	vascular	vascular	JJ
cord-252528-rgnhfcbx	243	25	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	243	26	.	.	.
cord-252528-rgnhfcbx	244	1	However	however	RB
cord-252528-rgnhfcbx	244	2	,	,	,
cord-252528-rgnhfcbx	244	3	excessive	excessive	JJ
cord-252528-rgnhfcbx	244	4	pro	pro	JJ
cord-252528-rgnhfcbx	244	5	-	-	JJ
cord-252528-rgnhfcbx	244	6	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	244	7	cytokine	cytokine	NN
cord-252528-rgnhfcbx	244	8	release	release	NN
cord-252528-rgnhfcbx	244	9	might	may	MD
cord-252528-rgnhfcbx	244	10	not	not	RB
cord-252528-rgnhfcbx	244	11	be	be	VB
cord-252528-rgnhfcbx	244	12	the	the	DT
cord-252528-rgnhfcbx	244	13	only	only	JJ
cord-252528-rgnhfcbx	244	14	etiology	etiology	NN
cord-252528-rgnhfcbx	244	15	of	of	IN
cord-252528-rgnhfcbx	244	16	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	244	17	state	state	NN
cord-252528-rgnhfcbx	244	18	in	in	IN
cord-252528-rgnhfcbx	244	19	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	244	20	,	,	,
cord-252528-rgnhfcbx	244	21	and	and	CC
cord-252528-rgnhfcbx	244	22	its	-PRON-	PRP$
cord-252528-rgnhfcbx	244	23	significance	significance	NN
cord-252528-rgnhfcbx	244	24	in	in	IN
cord-252528-rgnhfcbx	244	25	the	the	DT
cord-252528-rgnhfcbx	244	26	pathogenesis	pathogenesis	NN
cord-252528-rgnhfcbx	244	27	of	of	IN
cord-252528-rgnhfcbx	244	28	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	244	29	state	state	NN
cord-252528-rgnhfcbx	244	30	in	in	IN
cord-252528-rgnhfcbx	244	31	severe	severe	JJ
cord-252528-rgnhfcbx	244	32	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	244	33	should	should	MD
cord-252528-rgnhfcbx	244	34	be	be	VB
cord-252528-rgnhfcbx	244	35	investigated	investigate	VBN
cord-252528-rgnhfcbx	244	36	in	in	IN
cord-252528-rgnhfcbx	244	37	future	future	JJ
cord-252528-rgnhfcbx	244	38	studies	study	NNS
cord-252528-rgnhfcbx	244	39	.	.	.
cord-252528-rgnhfcbx	245	1	Because	because	IN
cord-252528-rgnhfcbx	245	2	of	of	IN
cord-252528-rgnhfcbx	245	3	structural	structural	JJ
cord-252528-rgnhfcbx	245	4	similarities	similarity	NNS
cord-252528-rgnhfcbx	245	5	between	between	IN
cord-252528-rgnhfcbx	245	6	receptor	receptor	NN
cord-252528-rgnhfcbx	245	7	binding	bind	VBG
cord-252528-rgnhfcbx	245	8	proteins	protein	NNS
cord-252528-rgnhfcbx	245	9	of	of	IN
cord-252528-rgnhfcbx	245	10	SARS	SARS	NNP
cord-252528-rgnhfcbx	245	11	-	-	HYPH
cord-252528-rgnhfcbx	245	12	CoV	CoV	NNP
cord-252528-rgnhfcbx	245	13	and	and	CC
cord-252528-rgnhfcbx	245	14	SARS	SARS	NNP
cord-252528-rgnhfcbx	245	15	-	-	HYPH
cord-252528-rgnhfcbx	245	16	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	245	17	,	,	,
cord-252528-rgnhfcbx	245	18	SARS	SARS	NNP
cord-252528-rgnhfcbx	245	19	-	-	HYPH
cord-252528-rgnhfcbx	245	20	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	245	21	infection	infection	NN
cord-252528-rgnhfcbx	245	22	is	be	VBZ
cord-252528-rgnhfcbx	245	23	likely	likely	JJ
cord-252528-rgnhfcbx	245	24	to	to	TO
cord-252528-rgnhfcbx	245	25	result	result	VB
cord-252528-rgnhfcbx	245	26	in	in	IN
cord-252528-rgnhfcbx	245	27	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	245	28	down	down	NN
cord-252528-rgnhfcbx	245	29	-	-	HYPH
cord-252528-rgnhfcbx	245	30	regulation	regulation	NN
cord-252528-rgnhfcbx	245	31	,	,	,
cord-252528-rgnhfcbx	245	32	which	which	WDT
cord-252528-rgnhfcbx	245	33	has	have	VBZ
cord-252528-rgnhfcbx	245	34	been	be	VBN
cord-252528-rgnhfcbx	245	35	confirmed	confirm	VBN
cord-252528-rgnhfcbx	245	36	in	in	IN
cord-252528-rgnhfcbx	245	37	SARS	SARS	NNP
cord-252528-rgnhfcbx	245	38	-	-	HYPH
cord-252528-rgnhfcbx	245	39	CoV	CoV	NNP
cord-252528-rgnhfcbx	245	40	infection	infection	NN
cord-252528-rgnhfcbx	245	41	previously	previously	RB
cord-252528-rgnhfcbx	245	42	.	.	.
cord-252528-rgnhfcbx	246	1	This	this	DT
cord-252528-rgnhfcbx	246	2	hypothesis	hypothesis	NN
cord-252528-rgnhfcbx	246	3	is	be	VBZ
cord-252528-rgnhfcbx	246	4	currently	currently	RB
cord-252528-rgnhfcbx	246	5	supported	support	VBN
cord-252528-rgnhfcbx	246	6	by	by	IN
cord-252528-rgnhfcbx	246	7	the	the	DT
cord-252528-rgnhfcbx	246	8	prediction	prediction	NN
cord-252528-rgnhfcbx	246	9	using	use	VBG
cord-252528-rgnhfcbx	246	10	an	an	DT
cord-252528-rgnhfcbx	246	11	interactome	interactome	NN
cord-252528-rgnhfcbx	246	12	model	model	NN
cord-252528-rgnhfcbx	246	13	,	,	,
cord-252528-rgnhfcbx	246	14	but	but	CC
cord-252528-rgnhfcbx	246	15	further	further	JJ
cord-252528-rgnhfcbx	246	16	experimental	experimental	JJ
cord-252528-rgnhfcbx	246	17	studies	study	NNS
cord-252528-rgnhfcbx	246	18	are	be	VBP
cord-252528-rgnhfcbx	246	19	needed	need	VBN
cord-252528-rgnhfcbx	246	20	to	to	TO
cord-252528-rgnhfcbx	246	21	confirm	confirm	VB
cord-252528-rgnhfcbx	246	22	the	the	DT
cord-252528-rgnhfcbx	246	23	hypothesis	hypothesis	NN
cord-252528-rgnhfcbx	246	24	.	.	.
cord-252528-rgnhfcbx	247	1	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	247	2	down	down	NN
cord-252528-rgnhfcbx	247	3	-	-	HYPH
cord-252528-rgnhfcbx	247	4	regulation	regulation	NN
cord-252528-rgnhfcbx	247	5	can	can	MD
cord-252528-rgnhfcbx	247	6	lead	lead	VB
cord-252528-rgnhfcbx	247	7	to	to	IN
cord-252528-rgnhfcbx	247	8	Ang	Ang	NNP
cord-252528-rgnhfcbx	247	9	II	II	NNP
cord-252528-rgnhfcbx	247	10	-	-	HYPH
cord-252528-rgnhfcbx	247	11	mediated	mediate	VBN
cord-252528-rgnhfcbx	247	12	vascular	vascular	JJ
cord-252528-rgnhfcbx	247	13	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	247	14	and	and	CC
cord-252528-rgnhfcbx	247	15	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	247	16	.	.	.
cord-252528-rgnhfcbx	248	1	Furthermore	furthermore	RB
cord-252528-rgnhfcbx	248	2	,	,	,
cord-252528-rgnhfcbx	248	3	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	248	4	down	down	NN
cord-252528-rgnhfcbx	248	5	-	-	HYPH
cord-252528-rgnhfcbx	248	6	regulation	regulation	NN
cord-252528-rgnhfcbx	248	7	and	and	CC
cord-252528-rgnhfcbx	248	8	excessive	excessive	JJ
cord-252528-rgnhfcbx	248	9	pro	pro	JJ
cord-252528-rgnhfcbx	248	10	-	-	JJ
cord-252528-rgnhfcbx	248	11	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	248	12	cytokine	cytokine	NN
cord-252528-rgnhfcbx	248	13	release	release	NN
cord-252528-rgnhfcbx	248	14	can	can	MD
cord-252528-rgnhfcbx	248	15	mutually	mutually	RB
cord-252528-rgnhfcbx	248	16	promote	promote	VB
cord-252528-rgnhfcbx	248	17	the	the	DT
cord-252528-rgnhfcbx	248	18	pro	pro	JJ
cord-252528-rgnhfcbx	248	19	-	-	JJ
cord-252528-rgnhfcbx	248	20	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	248	21	activities	activity	NNS
cord-252528-rgnhfcbx	248	22	of	of	IN
cord-252528-rgnhfcbx	248	23	each	each	DT
cord-252528-rgnhfcbx	248	24	other	other	JJ
cord-252528-rgnhfcbx	248	25	.	.	.
cord-252528-rgnhfcbx	249	1	Understanding	understand	VBG
cord-252528-rgnhfcbx	249	2	the	the	DT
cord-252528-rgnhfcbx	249	3	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	249	4	behind	behind	IN
cord-252528-rgnhfcbx	249	5	the	the	DT
cord-252528-rgnhfcbx	249	6	vascular	vascular	JJ
cord-252528-rgnhfcbx	249	7	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	249	8	events	event	NNS
cord-252528-rgnhfcbx	249	9	in	in	IN
cord-252528-rgnhfcbx	249	10	severe	severe	JJ
cord-252528-rgnhfcbx	249	11	patients	patient	NNS
cord-252528-rgnhfcbx	249	12	with	with	IN
cord-252528-rgnhfcbx	249	13	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	249	14	is	be	VBZ
cord-252528-rgnhfcbx	249	15	essential	essential	JJ
cord-252528-rgnhfcbx	249	16	for	for	IN
cord-252528-rgnhfcbx	249	17	the	the	DT
cord-252528-rgnhfcbx	249	18	prevention	prevention	NN
cord-252528-rgnhfcbx	249	19	and	and	CC
cord-252528-rgnhfcbx	249	20	treatment	treatment	NN
cord-252528-rgnhfcbx	249	21	of	of	IN
cord-252528-rgnhfcbx	249	22	vascular	vascular	JJ
cord-252528-rgnhfcbx	249	23	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	249	24	in	in	IN
cord-252528-rgnhfcbx	249	25	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	249	26	.	.	.
cord-252528-rgnhfcbx	250	1	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	250	2	/	/	SYM
cord-252528-rgnhfcbx	250	3	ARB	ARB	NNP
cord-252528-rgnhfcbx	250	4	can	can	MD
cord-252528-rgnhfcbx	250	5	prevent	prevent	VB
cord-252528-rgnhfcbx	250	6	hypercoagulable	hypercoagulable	JJ
cord-252528-rgnhfcbx	250	7	state	state	NN
cord-252528-rgnhfcbx	250	8	by	by	IN
cord-252528-rgnhfcbx	250	9	activating	activate	VBG
cord-252528-rgnhfcbx	250	10	ACE2/	ACE2/	NNP
cord-252528-rgnhfcbx	251	1	Ang	Ang	NNP
cord-252528-rgnhfcbx	251	2	1	1	CD
cord-252528-rgnhfcbx	251	3	-	-	SYM
cord-252528-rgnhfcbx	251	4	7	7	CD
cord-252528-rgnhfcbx	251	5	/Mas	/Mas	NNP
cord-252528-rgnhfcbx	251	6	receptor	receptor	NN
cord-252528-rgnhfcbx	251	7	axis	axis	NN
cord-252528-rgnhfcbx	251	8	while	while	IN
cord-252528-rgnhfcbx	251	9	inhibiting	inhibit	VBG
cord-252528-rgnhfcbx	251	10	ACE	ACE	NNP
cord-252528-rgnhfcbx	251	11	/	/	SYM
cord-252528-rgnhfcbx	251	12	Ang	Ang	NNP
cord-252528-rgnhfcbx	251	13	II	II	NNP
cord-252528-rgnhfcbx	251	14	/	/	SYM
cord-252528-rgnhfcbx	251	15	AT1	at1	NN
cord-252528-rgnhfcbx	251	16	receptor	receptor	NN
cord-252528-rgnhfcbx	251	17	axis	axis	NN
cord-252528-rgnhfcbx	251	18	,	,	,
cord-252528-rgnhfcbx	251	19	which	which	WDT
cord-252528-rgnhfcbx	251	20	possibly	possibly	RB
cord-252528-rgnhfcbx	251	21	explains	explain	VBZ
cord-252528-rgnhfcbx	251	22	the	the	DT
cord-252528-rgnhfcbx	251	23	reduced	reduce	VBN
cord-252528-rgnhfcbx	251	24	incidence	incidence	NN
cord-252528-rgnhfcbx	251	25	of	of	IN
cord-252528-rgnhfcbx	251	26	DIC	DIC	NNP
cord-252528-rgnhfcbx	251	27	in	in	IN
cord-252528-rgnhfcbx	251	28	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	251	29	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	251	30	patients	patient	NNS
cord-252528-rgnhfcbx	251	31	receiving	receive	VBG
cord-252528-rgnhfcbx	251	32	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	251	33	/	/	SYM
cord-252528-rgnhfcbx	251	34	ARB	arb	NN
cord-252528-rgnhfcbx	251	35	treatment	treatment	NN
cord-252528-rgnhfcbx	251	36	.	.	.
cord-252528-rgnhfcbx	252	1	Anti	anti	JJ
cord-252528-rgnhfcbx	252	2	-	-	JJ
cord-252528-rgnhfcbx	252	3	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	252	4	medications	medication	NNS
cord-252528-rgnhfcbx	252	5	,	,	,
cord-252528-rgnhfcbx	252	6	including	include	VBG
cord-252528-rgnhfcbx	252	7	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	252	8	,	,	,
cord-252528-rgnhfcbx	252	9	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	252	10	,	,	,
cord-252528-rgnhfcbx	252	11	and	and	CC
cord-252528-rgnhfcbx	252	12	hydroxychloroquine	hydroxychloroquine	NNP
cord-252528-rgnhfcbx	252	13	,	,	,
cord-252528-rgnhfcbx	252	14	could	could	MD
cord-252528-rgnhfcbx	252	15	be	be	VB
cord-252528-rgnhfcbx	252	16	an	an	DT
cord-252528-rgnhfcbx	252	17	effective	effective	JJ
cord-252528-rgnhfcbx	252	18	treatment	treatment	NN
cord-252528-rgnhfcbx	252	19	to	to	TO
cord-252528-rgnhfcbx	252	20	control	control	VB
cord-252528-rgnhfcbx	252	21	the	the	DT
cord-252528-rgnhfcbx	252	22	over	over	RB
cord-252528-rgnhfcbx	252	23	-	-	HYPH
cord-252528-rgnhfcbx	252	24	activated	activate	VBN
cord-252528-rgnhfcbx	252	25	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	252	26	response	response	NN
cord-252528-rgnhfcbx	252	27	and	and	CC
cord-252528-rgnhfcbx	252	28	have	have	VBP
cord-252528-rgnhfcbx	252	29	the	the	DT
cord-252528-rgnhfcbx	252	30	potential	potential	NN
cord-252528-rgnhfcbx	252	31	to	to	TO
cord-252528-rgnhfcbx	252	32	reduce	reduce	VB
cord-252528-rgnhfcbx	252	33	the	the	DT
cord-252528-rgnhfcbx	252	34	risk	risk	NN
cord-252528-rgnhfcbx	252	35	of	of	IN
cord-252528-rgnhfcbx	252	36	vascular	vascular	JJ
cord-252528-rgnhfcbx	252	37	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	252	38	in	in	IN
cord-252528-rgnhfcbx	252	39	severe	severe	JJ
cord-252528-rgnhfcbx	252	40	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	252	41	.	.	.
cord-252528-rgnhfcbx	253	1	The	the	DT
cord-252528-rgnhfcbx	253	2	potential	potential	NN
cord-252528-rgnhfcbx	253	3	of	of	IN
cord-252528-rgnhfcbx	253	4	these	these	DT
cord-252528-rgnhfcbx	253	5	anti	anti	JJ
cord-252528-rgnhfcbx	253	6	-	-	JJ
cord-252528-rgnhfcbx	253	7	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	253	8	medications	medication	NNS
cord-252528-rgnhfcbx	253	9	to	to	TO
cord-252528-rgnhfcbx	253	10	reduce	reduce	VB
cord-252528-rgnhfcbx	253	11	vascular	vascular	JJ
cord-252528-rgnhfcbx	253	12	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	253	13	events	event	NNS
cord-252528-rgnhfcbx	253	14	,	,	,
cord-252528-rgnhfcbx	253	15	along	along	IN
cord-252528-rgnhfcbx	253	16	with	with	IN
cord-252528-rgnhfcbx	253	17	the	the	DT
cord-252528-rgnhfcbx	253	18	optimum	optimum	JJ
cord-252528-rgnhfcbx	253	19	choice	choice	NN
cord-252528-rgnhfcbx	253	20	of	of	IN
cord-252528-rgnhfcbx	253	21	an	an	DT
cord-252528-rgnhfcbx	253	22	anti	anti	JJ
cord-252528-rgnhfcbx	253	23	-	-	JJ
cord-252528-rgnhfcbx	253	24	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	253	25	drug	drug	NN
cord-252528-rgnhfcbx	253	26	to	to	TO
cord-252528-rgnhfcbx	253	27	control	control	VB
cord-252528-rgnhfcbx	253	28	the	the	DT
cord-252528-rgnhfcbx	253	29	excessive	excessive	JJ
cord-252528-rgnhfcbx	253	30	cytokine	cytokine	NN
cord-252528-rgnhfcbx	253	31	release	release	NN
cord-252528-rgnhfcbx	253	32	,	,	,
cord-252528-rgnhfcbx	253	33	detailed	detailed	JJ
cord-252528-rgnhfcbx	253	34	standards	standard	NNS
cord-252528-rgnhfcbx	253	35	for	for	IN
cord-252528-rgnhfcbx	253	36	patient	patient	NN
cord-252528-rgnhfcbx	253	37	selection	selection	NN
cord-252528-rgnhfcbx	253	38	,	,	,
cord-252528-rgnhfcbx	253	39	as	as	RB
cord-252528-rgnhfcbx	253	40	well	well	RB
cord-252528-rgnhfcbx	253	41	as	as	IN
cord-252528-rgnhfcbx	253	42	the	the	DT
cord-252528-rgnhfcbx	253	43	optimal	optimal	JJ
cord-252528-rgnhfcbx	253	44	time	time	NN
cord-252528-rgnhfcbx	253	45	of	of	IN
cord-252528-rgnhfcbx	253	46	initiation	initiation	NN
cord-252528-rgnhfcbx	253	47	and	and	CC
cord-252528-rgnhfcbx	253	48	the	the	DT
cord-252528-rgnhfcbx	253	49	optimal	optimal	JJ
cord-252528-rgnhfcbx	253	50	duration	duration	NN
cord-252528-rgnhfcbx	253	51	of	of	IN
cord-252528-rgnhfcbx	253	52	the	the	DT
cord-252528-rgnhfcbx	253	53	anti	anti	JJ
cord-252528-rgnhfcbx	253	54	-	-	JJ
cord-252528-rgnhfcbx	253	55	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	253	56	therapy	therapy	NN
cord-252528-rgnhfcbx	253	57	,	,	,
cord-252528-rgnhfcbx	253	58	are	be	VBP
cord-252528-rgnhfcbx	253	59	remained	remain	VBN
cord-252528-rgnhfcbx	253	60	to	to	TO
cord-252528-rgnhfcbx	253	61	be	be	VB
cord-252528-rgnhfcbx	253	62	elucidated	elucidate	VBN
cord-252528-rgnhfcbx	253	63	in	in	IN
cord-252528-rgnhfcbx	253	64	future	future	JJ
cord-252528-rgnhfcbx	253	65	clinical	clinical	JJ
cord-252528-rgnhfcbx	253	66	studies	study	NNS
cord-252528-rgnhfcbx	253	67	.	.	.
cord-252528-rgnhfcbx	254	1	Author	author	NN
cord-252528-rgnhfcbx	254	2	contributions	contribution	NNS
cord-252528-rgnhfcbx	255	1	All	all	DT
cord-252528-rgnhfcbx	255	2	authors	author	NNS
cord-252528-rgnhfcbx	255	3	contributed	contribute	VBD
cord-252528-rgnhfcbx	255	4	equally	equally	RB
cord-252528-rgnhfcbx	255	5	to	to	IN
cord-252528-rgnhfcbx	255	6	the	the	DT
cord-252528-rgnhfcbx	255	7	preparation	preparation	NN
cord-252528-rgnhfcbx	255	8	of	of	IN
cord-252528-rgnhfcbx	255	9	this	this	DT
cord-252528-rgnhfcbx	255	10	manuscript	manuscript	NN
cord-252528-rgnhfcbx	255	11	.	.	.
cord-252528-rgnhfcbx	255	12	 	 	_SP
cord-252528-rgnhfcbx	256	1	Conflict	conflict	NN
cord-252528-rgnhfcbx	256	2	of	of	IN
cord-252528-rgnhfcbx	256	3	interest	interest	NN
cord-252528-rgnhfcbx	257	1	There	there	EX
cord-252528-rgnhfcbx	257	2	is	be	VBZ
cord-252528-rgnhfcbx	257	3	no	no	DT
cord-252528-rgnhfcbx	257	4	conflict	conflict	NN
cord-252528-rgnhfcbx	257	5	of	of	IN
cord-252528-rgnhfcbx	257	6	interest	interest	NN
cord-252528-rgnhfcbx	257	7	involved	involve	VBN
cord-252528-rgnhfcbx	257	8	in	in	IN
cord-252528-rgnhfcbx	257	9	the	the	DT
cord-252528-rgnhfcbx	257	10	article	article	NN
cord-252528-rgnhfcbx	257	11	.	.	.
cord-252528-rgnhfcbx	258	1	Informed	informed	JJ
cord-252528-rgnhfcbx	258	2	consent	consent	NN
cord-252528-rgnhfcbx	258	3	Consents	Consents	NNP
cord-252528-rgnhfcbx	258	4	in	in	IN
cord-252528-rgnhfcbx	258	5	written	write	VBN
cord-252528-rgnhfcbx	258	6	form	form	NN
cord-252528-rgnhfcbx	258	7	were	be	VBD
cord-252528-rgnhfcbx	258	8	obtained	obtain	VBN
cord-252528-rgnhfcbx	258	9	from	from	IN
cord-252528-rgnhfcbx	258	10	all	all	DT
cord-252528-rgnhfcbx	258	11	participants	participant	NNS
cord-252528-rgnhfcbx	258	12	.	.	.
cord-252528-rgnhfcbx	259	1	All	all	DT
cord-252528-rgnhfcbx	259	2	authors	author	NNS
cord-252528-rgnhfcbx	259	3	have	have	VBP
cord-252528-rgnhfcbx	259	4	read	read	VBN
cord-252528-rgnhfcbx	259	5	the	the	DT
cord-252528-rgnhfcbx	259	6	manuscript	manuscript	NN
cord-252528-rgnhfcbx	259	7	and	and	CC
cord-252528-rgnhfcbx	259	8	approved	approve	VBD
cord-252528-rgnhfcbx	259	9	the	the	DT
cord-252528-rgnhfcbx	259	10	manuscript	manuscript	NN
cord-252528-rgnhfcbx	259	11	for	for	IN
cord-252528-rgnhfcbx	259	12	publication	publication	NN
cord-252528-rgnhfcbx	259	13	.	.	.
cord-252528-rgnhfcbx	260	1	Abnormal	abnormal	JJ
cord-252528-rgnhfcbx	260	2	coagulation	coagulation	NN
cord-252528-rgnhfcbx	260	3	parameters	parameter	NNS
cord-252528-rgnhfcbx	260	4	are	be	VBP
cord-252528-rgnhfcbx	260	5	associated	associate	VBN
cord-252528-rgnhfcbx	260	6	with	with	IN
cord-252528-rgnhfcbx	260	7	poor	poor	JJ
cord-252528-rgnhfcbx	260	8	prognosis	prognosis	NN
cord-252528-rgnhfcbx	260	9	in	in	IN
cord-252528-rgnhfcbx	260	10	patients	patient	NNS
cord-252528-rgnhfcbx	260	11	with	with	IN
cord-252528-rgnhfcbx	260	12	novel	novel	JJ
cord-252528-rgnhfcbx	260	13	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	260	14	pneumonia	pneumonia	NN
cord-252528-rgnhfcbx	260	15	Clinical	clinical	JJ
cord-252528-rgnhfcbx	260	16	features	feature	NNS
cord-252528-rgnhfcbx	260	17	of	of	IN
cord-252528-rgnhfcbx	260	18	patients	patient	NNS
cord-252528-rgnhfcbx	260	19	infected	infect	VBN
cord-252528-rgnhfcbx	260	20	with	with	IN
cord-252528-rgnhfcbx	260	21	2019	2019	CD
cord-252528-rgnhfcbx	260	22	novel	novel	JJ
cord-252528-rgnhfcbx	260	23	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	260	24	in	in	IN
cord-252528-rgnhfcbx	260	25	Characteristics	characteristic	NNS
cord-252528-rgnhfcbx	260	26	of	of	IN
cord-252528-rgnhfcbx	260	27	lymphocyte	lymphocyte	NN
cord-252528-rgnhfcbx	260	28	subsets	subset	NNS
cord-252528-rgnhfcbx	260	29	and	and	CC
cord-252528-rgnhfcbx	260	30	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	260	31	in	in	IN
cord-252528-rgnhfcbx	260	32	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	260	33	blood	blood	NN
cord-252528-rgnhfcbx	260	34	of	of	IN
cord-252528-rgnhfcbx	260	35	123	123	CD
cord-252528-rgnhfcbx	260	36	hospitalized	hospitalize	VBN
cord-252528-rgnhfcbx	260	37	patients	patient	NNS
cord-252528-rgnhfcbx	260	38	with	with	IN
cord-252528-rgnhfcbx	260	39	2019	2019	CD
cord-252528-rgnhfcbx	260	40	novel	novel	JJ
cord-252528-rgnhfcbx	260	41	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	260	42	pneumonia	pneumonia	NN
cord-252528-rgnhfcbx	260	43	(	(	-LRB-
cord-252528-rgnhfcbx	260	44	NCP	NCP	NNP
cord-252528-rgnhfcbx	260	45	)	)	-RRB-
cord-252528-rgnhfcbx	261	1	Exuberant	exuberant	JJ
cord-252528-rgnhfcbx	261	2	elevation	elevation	NN
cord-252528-rgnhfcbx	261	3	of	of	IN
cord-252528-rgnhfcbx	261	4	IP-10	IP-10	NNP
cord-252528-rgnhfcbx	261	5	,	,	,
cord-252528-rgnhfcbx	261	6	MCP-3	MCP-3	NNP
cord-252528-rgnhfcbx	261	7	and	and	CC
cord-252528-rgnhfcbx	261	8	IL-1ra	IL-1ra	NNP
cord-252528-rgnhfcbx	261	9	during	during	IN
cord-252528-rgnhfcbx	261	10	SARS	SARS	NNP
cord-252528-rgnhfcbx	261	11	-	-	HYPH
cord-252528-rgnhfcbx	261	12	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	261	13	infection	infection	NN
cord-252528-rgnhfcbx	261	14	is	be	VBZ
cord-252528-rgnhfcbx	261	15	associated	associate	VBN
cord-252528-rgnhfcbx	261	16	with	with	IN
cord-252528-rgnhfcbx	261	17	disease	disease	NN
cord-252528-rgnhfcbx	261	18	severity	severity	NN
cord-252528-rgnhfcbx	261	19	and	and	CC
cord-252528-rgnhfcbx	261	20	fatal	fatal	JJ
cord-252528-rgnhfcbx	261	21	outcome	outcome	NN
cord-252528-rgnhfcbx	261	22	Longitudinal	longitudinal	JJ
cord-252528-rgnhfcbx	261	23	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	261	24	of	of	IN
cord-252528-rgnhfcbx	261	25	lymphocyte	lymphocyte	NN
cord-252528-rgnhfcbx	261	26	responses	response	NNS
cord-252528-rgnhfcbx	261	27	and	and	CC
cord-252528-rgnhfcbx	261	28	cytokine	cytokine	NN
cord-252528-rgnhfcbx	261	29	profiles	profile	NNS
cord-252528-rgnhfcbx	261	30	in	in	IN
cord-252528-rgnhfcbx	261	31	the	the	DT
cord-252528-rgnhfcbx	261	32	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	261	33	blood	blood	NN
cord-252528-rgnhfcbx	261	34	of	of	IN
cord-252528-rgnhfcbx	261	35	SARS	SARS	NNP
cord-252528-rgnhfcbx	261	36	-	-	HYPH
cord-252528-rgnhfcbx	261	37	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	261	38	infected	infect	VBN
cord-252528-rgnhfcbx	261	39	patients	patient	NNS
cord-252528-rgnhfcbx	261	40	Aberrant	aberrant	JJ
cord-252528-rgnhfcbx	261	41	pathogenic	pathogenic	JJ
cord-252528-rgnhfcbx	261	42	GM	GM	NNP
cord-252528-rgnhfcbx	261	43	-	-	HYPH
cord-252528-rgnhfcbx	261	44	CSF+	CSF+	NNP
cord-252528-rgnhfcbx	261	45	T	T	NNP
cord-252528-rgnhfcbx	261	46	cells	cell	NNS
cord-252528-rgnhfcbx	261	47	and	and	CC
cord-252528-rgnhfcbx	261	48	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	261	49	CD14+CD16	CD14+CD16	NNP
cord-252528-rgnhfcbx	261	50	+	+	CC
cord-252528-rgnhfcbx	261	51	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	261	52	in	in	IN
cord-252528-rgnhfcbx	261	53	severe	severe	JJ
cord-252528-rgnhfcbx	261	54	pulmonary	pulmonary	JJ
cord-252528-rgnhfcbx	261	55	syndrome	syndrome	NN
cord-252528-rgnhfcbx	261	56	patients	patient	NNS
cord-252528-rgnhfcbx	261	57	of	of	IN
cord-252528-rgnhfcbx	261	58	a	a	DT
cord-252528-rgnhfcbx	261	59	new	new	JJ
cord-252528-rgnhfcbx	261	60	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	261	61	Master	Master	NNP
cord-252528-rgnhfcbx	261	62	regulator	regulator	NN
cord-252528-rgnhfcbx	261	63	analysis	analysis	NN
cord-252528-rgnhfcbx	261	64	of	of	IN
cord-252528-rgnhfcbx	261	65	the	the	DT
cord-252528-rgnhfcbx	261	66	SARS	SARS	NNP
cord-252528-rgnhfcbx	261	67	-	-	HYPH
cord-252528-rgnhfcbx	261	68	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	261	69	/	/	SYM
cord-252528-rgnhfcbx	261	70	human	human	JJ
cord-252528-rgnhfcbx	261	71	interactome	interactome	NNP
cord-252528-rgnhfcbx	261	72	China	China	NNP
cord-252528-rgnhfcbx	261	73	Medical	Medical	NNP
cord-252528-rgnhfcbx	261	74	Treatment	Treatment	NNP
cord-252528-rgnhfcbx	261	75	Expert	Expert	NNP
cord-252528-rgnhfcbx	261	76	Group	Group	NNP
cord-252528-rgnhfcbx	261	77	for	for	IN
cord-252528-rgnhfcbx	261	78	C	C	NNP
cord-252528-rgnhfcbx	261	79	(	(	-LRB-
cord-252528-rgnhfcbx	261	80	2020	2020	CD
cord-252528-rgnhfcbx	261	81	)	)	-RRB-
cord-252528-rgnhfcbx	262	1	Clinical	clinical	JJ
cord-252528-rgnhfcbx	262	2	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	262	3	of	of	IN
cord-252528-rgnhfcbx	262	4	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	262	5	disease	disease	NN
cord-252528-rgnhfcbx	262	6	2019	2019	CD
cord-252528-rgnhfcbx	262	7	in	in	IN
cord-252528-rgnhfcbx	262	8	China	China	NNP
cord-252528-rgnhfcbx	262	9	D	D	NNP
cord-252528-rgnhfcbx	262	10	-	-	HYPH
cord-252528-rgnhfcbx	262	11	dimer	dimer	NN
cord-252528-rgnhfcbx	262	12	is	be	VBZ
cord-252528-rgnhfcbx	262	13	associated	associate	VBN
cord-252528-rgnhfcbx	262	14	with	with	IN
cord-252528-rgnhfcbx	262	15	severity	severity	NN
cord-252528-rgnhfcbx	262	16	of	of	IN
cord-252528-rgnhfcbx	262	17	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	262	18	disease	disease	NN
cord-252528-rgnhfcbx	262	19	2019	2019	CD
cord-252528-rgnhfcbx	262	20	:	:	:
cord-252528-rgnhfcbx	262	21	a	a	DT
cord-252528-rgnhfcbx	262	22	pooled	pool	VBN
cord-252528-rgnhfcbx	262	23	analysis	analysis	NN
cord-252528-rgnhfcbx	262	24	Coagulopathy	Coagulopathy	NNP
cord-252528-rgnhfcbx	262	25	and	and	CC
cord-252528-rgnhfcbx	262	26	antiphospholipid	antiphospholipid	NNP
cord-252528-rgnhfcbx	262	27	antibodies	antibody	NNS
cord-252528-rgnhfcbx	262	28	in	in	IN
cord-252528-rgnhfcbx	262	29	patients	patient	NNS
cord-252528-rgnhfcbx	262	30	with	with	IN
cord-252528-rgnhfcbx	262	31	Covid-19	Covid-19	NNP
cord-252528-rgnhfcbx	262	32	Antiphospholipid	Antiphospholipid	NNP
cord-252528-rgnhfcbx	262	33	antibodies	antibody	NNS
cord-252528-rgnhfcbx	262	34	in	in	IN
cord-252528-rgnhfcbx	262	35	HIV	HIV	NNP
cord-252528-rgnhfcbx	262	36	-	-	HYPH
cord-252528-rgnhfcbx	262	37	positive	positive	JJ
cord-252528-rgnhfcbx	262	38	patients	patient	NNS
cord-252528-rgnhfcbx	262	39	Infectious	infectious	JJ
cord-252528-rgnhfcbx	262	40	origin	origin	NN
cord-252528-rgnhfcbx	262	41	of	of	IN
cord-252528-rgnhfcbx	262	42	the	the	DT
cord-252528-rgnhfcbx	262	43	antiphospholipid	antiphospholipid	NNP
cord-252528-rgnhfcbx	262	44	syndrome	syndrome	NN
cord-252528-rgnhfcbx	262	45	Dysregulation	Dysregulation	NNP
cord-252528-rgnhfcbx	262	46	of	of	IN
cord-252528-rgnhfcbx	262	47	immune	immune	JJ
cord-252528-rgnhfcbx	262	48	response	response	NN
cord-252528-rgnhfcbx	262	49	in	in	IN
cord-252528-rgnhfcbx	262	50	patients	patient	NNS
cord-252528-rgnhfcbx	262	51	with	with	IN
cord-252528-rgnhfcbx	262	52	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	262	53	in	in	IN
cord-252528-rgnhfcbx	262	54	Wuhan	Wuhan	NNP
cord-252528-rgnhfcbx	262	55	,	,	,
cord-252528-rgnhfcbx	262	56	China	China	NNP
cord-252528-rgnhfcbx	262	57	Characteristics	Characteristics	NNP
cord-252528-rgnhfcbx	262	58	of	of	IN
cord-252528-rgnhfcbx	262	59	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	262	60	lymphocyte	lymphocyte	NN
cord-252528-rgnhfcbx	262	61	subset	subset	VBN
cord-252528-rgnhfcbx	262	62	alteration	alteration	NN
cord-252528-rgnhfcbx	262	63	in	in	IN
cord-252528-rgnhfcbx	262	64	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	262	65	pneumonia	pneumonia	NN
cord-252528-rgnhfcbx	262	66	Clinical	clinical	JJ
cord-252528-rgnhfcbx	262	67	characteristics	characteristic	NNS
cord-252528-rgnhfcbx	262	68	of	of	IN
cord-252528-rgnhfcbx	262	69	Covid-19	covid-19	NN
cord-252528-rgnhfcbx	262	70	in	in	IN
cord-252528-rgnhfcbx	262	71	New	New	NNP
cord-252528-rgnhfcbx	262	72	York	York	NNP
cord-252528-rgnhfcbx	262	73	city	city	NN
cord-252528-rgnhfcbx	262	74	IFN-	ifn-	NN
cord-252528-rgnhfcbx	263	1	I	-PRON-	PRP
cord-252528-rgnhfcbx	263	2	response	response	VBP
cord-252528-rgnhfcbx	263	3	timing	timing	NN
cord-252528-rgnhfcbx	263	4	relative	relative	JJ
cord-252528-rgnhfcbx	263	5	to	to	IN
cord-252528-rgnhfcbx	263	6	virus	virus	NN
cord-252528-rgnhfcbx	263	7	replication	replication	NN
cord-252528-rgnhfcbx	263	8	determines	determine	VBZ
cord-252528-rgnhfcbx	263	9	MERS	MERS	NNP
cord-252528-rgnhfcbx	263	10	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	263	11	infection	infection	NN
cord-252528-rgnhfcbx	263	12	outcomes	outcome	NNS
cord-252528-rgnhfcbx	264	1	Dysregulated	Dysregulated	NNP
cord-252528-rgnhfcbx	264	2	type	type	NN
cord-252528-rgnhfcbx	265	1	I	-PRON-	PRP
cord-252528-rgnhfcbx	265	2	interferon	interferon	VBD
cord-252528-rgnhfcbx	265	3	and	and	CC
cord-252528-rgnhfcbx	265	4	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	265	5	monocyte	monocyte	JJ
cord-252528-rgnhfcbx	265	6	-	-	HYPH
cord-252528-rgnhfcbx	265	7	macrophage	macrophage	NN
cord-252528-rgnhfcbx	265	8	responses	response	NNS
cord-252528-rgnhfcbx	265	9	cause	cause	VBP
cord-252528-rgnhfcbx	265	10	lethal	lethal	JJ
cord-252528-rgnhfcbx	265	11	pneumonia	pneumonia	NN
cord-252528-rgnhfcbx	265	12	in	in	IN
cord-252528-rgnhfcbx	265	13	SARS	SARS	NNP
cord-252528-rgnhfcbx	265	14	-	-	HYPH
cord-252528-rgnhfcbx	265	15	CoV	CoV	NNP
cord-252528-rgnhfcbx	265	16	-	-	HYPH
cord-252528-rgnhfcbx	265	17	infected	infect	VBN
cord-252528-rgnhfcbx	265	18	mice	mouse	NNS
cord-252528-rgnhfcbx	265	19	GM	GM	NNP
cord-252528-rgnhfcbx	265	20	-	-	HYPH
cord-252528-rgnhfcbx	265	21	CSF	CSF	NNP
cord-252528-rgnhfcbx	265	22	:	:	:
cord-252528-rgnhfcbx	265	23	from	from	IN
cord-252528-rgnhfcbx	265	24	growth	growth	NN
cord-252528-rgnhfcbx	265	25	factor	factor	NN
cord-252528-rgnhfcbx	265	26	to	to	IN
cord-252528-rgnhfcbx	265	27	central	central	JJ
cord-252528-rgnhfcbx	265	28	mediator	mediator	NN
cord-252528-rgnhfcbx	265	29	of	of	IN
cord-252528-rgnhfcbx	265	30	tissue	tissue	NN
cord-252528-rgnhfcbx	265	31	inflammation	inflammation	NN
cord-252528-rgnhfcbx	265	32	GM	GM	NNP
cord-252528-rgnhfcbx	265	33	-	-	HYPH
cord-252528-rgnhfcbx	265	34	CSF	CSF	NNP
cord-252528-rgnhfcbx	265	35	grown	grow	VBN
cord-252528-rgnhfcbx	265	36	bone	bone	NN
cord-252528-rgnhfcbx	265	37	marrow	marrow	NN
cord-252528-rgnhfcbx	265	38	derived	derive	VBN
cord-252528-rgnhfcbx	265	39	cells	cell	NNS
cord-252528-rgnhfcbx	265	40	are	be	VBP
cord-252528-rgnhfcbx	265	41	composed	compose	VBN
cord-252528-rgnhfcbx	265	42	of	of	IN
cord-252528-rgnhfcbx	265	43	phenotypically	phenotypically	RB
cord-252528-rgnhfcbx	265	44	different	different	JJ
cord-252528-rgnhfcbx	265	45	dendritic	dendritic	JJ
cord-252528-rgnhfcbx	265	46	cells	cell	NNS
cord-252528-rgnhfcbx	265	47	and	and	CC
cord-252528-rgnhfcbx	265	48	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	266	1	GM	GM	NNP
cord-252528-rgnhfcbx	266	2	-	-	HYPH
cord-252528-rgnhfcbx	266	3	CSF	CSF	NNP
cord-252528-rgnhfcbx	266	4	regulates	regulate	VBZ
cord-252528-rgnhfcbx	266	5	alveolar	alveolar	JJ
cord-252528-rgnhfcbx	266	6	macrophage	macrophage	NN
cord-252528-rgnhfcbx	266	7	differentiation	differentiation	NN
cord-252528-rgnhfcbx	266	8	and	and	CC
cord-252528-rgnhfcbx	266	9	innate	innate	JJ
cord-252528-rgnhfcbx	266	10	immunity	immunity	NN
cord-252528-rgnhfcbx	266	11	in	in	IN
cord-252528-rgnhfcbx	266	12	the	the	DT
cord-252528-rgnhfcbx	266	13	lung	lung	NN
cord-252528-rgnhfcbx	266	14	through	through	IN
cord-252528-rgnhfcbx	266	15	PU.1	PU.1	NNP
cord-252528-rgnhfcbx	266	16	.	.	.
cord-252528-rgnhfcbx	267	1	Immunity	Immunity	NNP
cord-252528-rgnhfcbx	267	2	GM	GM	NNP
cord-252528-rgnhfcbx	267	3	-	-	HYPH
cord-252528-rgnhfcbx	267	4	CSF	csf	NN
cord-252528-rgnhfcbx	267	5	autoantibodies	autoantibody	NNS
cord-252528-rgnhfcbx	267	6	and	and	CC
cord-252528-rgnhfcbx	267	7	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	267	8	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	267	9	in	in	IN
cord-252528-rgnhfcbx	268	1	pulmonary	pulmonary	JJ
cord-252528-rgnhfcbx	268	2	alveolar	alveolar	NN
cord-252528-rgnhfcbx	268	3	proteinosis	proteinosis	NN
cord-252528-rgnhfcbx	268	4	Bone	Bone	NNP
cord-252528-rgnhfcbx	268	5	marrow	marrow	NN
cord-252528-rgnhfcbx	268	6	contains	contain	VBZ
cord-252528-rgnhfcbx	268	7	virus	virus	NN
cord-252528-rgnhfcbx	268	8	-	-	HYPH
cord-252528-rgnhfcbx	268	9	specific	specific	JJ
cord-252528-rgnhfcbx	268	10	cytotoxic	cytotoxic	JJ
cord-252528-rgnhfcbx	268	11	T	t	NN
cord-252528-rgnhfcbx	268	12	lymphocytes	lymphocyte	NNS
cord-252528-rgnhfcbx	268	13	Eosinophil	eosinophil	JJ
cord-252528-rgnhfcbx	268	14	differentiation	differentiation	NN
cord-252528-rgnhfcbx	268	15	in	in	IN
cord-252528-rgnhfcbx	268	16	the	the	DT
cord-252528-rgnhfcbx	268	17	bone	bone	NN
cord-252528-rgnhfcbx	268	18	marrow	marrow	NN
cord-252528-rgnhfcbx	268	19	is	be	VBZ
cord-252528-rgnhfcbx	268	20	inhibited	inhibit	VBN
cord-252528-rgnhfcbx	268	21	by	by	IN
cord-252528-rgnhfcbx	268	22	T	T	NNP
cord-252528-rgnhfcbx	268	23	cell	cell	NN
cord-252528-rgnhfcbx	268	24	-	-	HYPH
cord-252528-rgnhfcbx	268	25	derived	derive	VBN
cord-252528-rgnhfcbx	268	26	IFN	IFN	NNP
cord-252528-rgnhfcbx	268	27	-	-	HYPH
cord-252528-rgnhfcbx	268	28	gamma	gamma	NN
cord-252528-rgnhfcbx	268	29	IFNγ	IFNγ	NNS
cord-252528-rgnhfcbx	268	30	induces	induce	VBZ
cord-252528-rgnhfcbx	268	31	monopoiesis	monopoiesis	NN
cord-252528-rgnhfcbx	268	32	and	and	CC
cord-252528-rgnhfcbx	268	33	inhibits	inhibit	VBZ
cord-252528-rgnhfcbx	268	34	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	268	35	development	development	NN
cord-252528-rgnhfcbx	268	36	during	during	IN
cord-252528-rgnhfcbx	268	37	inflammation	inflammation	NN
cord-252528-rgnhfcbx	268	38	Cytotoxic	Cytotoxic	NNP
cord-252528-rgnhfcbx	268	39	CD8	CD8	NNP
cord-252528-rgnhfcbx	268	40	+	+	CC
cord-252528-rgnhfcbx	268	41	T	t	NN
cord-252528-rgnhfcbx	268	42	cells	cell	NNS
cord-252528-rgnhfcbx	268	43	stimulate	stimulate	VBP
cord-252528-rgnhfcbx	268	44	hematopoietic	hematopoietic	JJ
cord-252528-rgnhfcbx	268	45	progenitors	progenitor	NNS
cord-252528-rgnhfcbx	268	46	by	by	IN
cord-252528-rgnhfcbx	268	47	promoting	promote	VBG
cord-252528-rgnhfcbx	268	48	cytokine	cytokine	NN
cord-252528-rgnhfcbx	268	49	release	release	NN
cord-252528-rgnhfcbx	268	50	from	from	IN
cord-252528-rgnhfcbx	268	51	bone	bone	NN
cord-252528-rgnhfcbx	268	52	marrow	marrow	NN
cord-252528-rgnhfcbx	268	53	mesenchymal	mesenchymal	JJ
cord-252528-rgnhfcbx	268	54	stromal	stromal	NN
cord-252528-rgnhfcbx	268	55	cells	cell	NNS
cord-252528-rgnhfcbx	268	56	Direct	direct	JJ
cord-252528-rgnhfcbx	268	57	regulation	regulation	NN
cord-252528-rgnhfcbx	268	58	of	of	IN
cord-252528-rgnhfcbx	268	59	interleukin-6	interleukin-6	JJ
cord-252528-rgnhfcbx	268	60	expression	expression	NN
cord-252528-rgnhfcbx	268	61	by	by	IN
cord-252528-rgnhfcbx	268	62	Notch	notch	NN
cord-252528-rgnhfcbx	268	63	signaling	signaling	NN
cord-252528-rgnhfcbx	268	64	in	in	IN
cord-252528-rgnhfcbx	268	65	macrophages	macrophage	NNS
cord-252528-rgnhfcbx	268	66	Causes	cause	NNS
cord-252528-rgnhfcbx	268	67	,	,	,
cord-252528-rgnhfcbx	268	68	consequences	consequence	NNS
cord-252528-rgnhfcbx	268	69	,	,	,
cord-252528-rgnhfcbx	268	70	and	and	CC
cord-252528-rgnhfcbx	268	71	reversal	reversal	NN
cord-252528-rgnhfcbx	268	72	of	of	IN
cord-252528-rgnhfcbx	268	73	immune	immune	JJ
cord-252528-rgnhfcbx	268	74	system	system	NN
cord-252528-rgnhfcbx	268	75	aging	age	VBG
cord-252528-rgnhfcbx	268	76	Agedependent	Agedependent	NNP
cord-252528-rgnhfcbx	268	77	changes	change	NNS
cord-252528-rgnhfcbx	268	78	in	in	IN
cord-252528-rgnhfcbx	268	79	regulatory	regulatory	JJ
cord-252528-rgnhfcbx	268	80	T	t	NN
cord-252528-rgnhfcbx	268	81	lymphocyte	lymphocyte	NN
cord-252528-rgnhfcbx	268	82	development	development	NN
cord-252528-rgnhfcbx	268	83	and	and	CC
cord-252528-rgnhfcbx	268	84	function	function	NN
cord-252528-rgnhfcbx	268	85	:	:	:
cord-252528-rgnhfcbx	268	86	a	a	DT
cord-252528-rgnhfcbx	268	87	mini	mini	JJ
cord-252528-rgnhfcbx	268	88	-	-	NN
cord-252528-rgnhfcbx	268	89	review	review	JJ
cord-252528-rgnhfcbx	268	90	Polymorphism	polymorphism	NN
cord-252528-rgnhfcbx	268	91	of	of	IN
cord-252528-rgnhfcbx	268	92	HLA	HLA	NNP
cord-252528-rgnhfcbx	268	93	class	class	NN
cord-252528-rgnhfcbx	268	94	I	i	NN
cord-252528-rgnhfcbx	268	95	and	and	CC
cord-252528-rgnhfcbx	268	96	class	class	NN
cord-252528-rgnhfcbx	268	97	II	ii	CD
cord-252528-rgnhfcbx	268	98	alleles	allele	NNS
cord-252528-rgnhfcbx	268	99	in	in	IN
cord-252528-rgnhfcbx	268	100	influenza	influenza	NN
cord-252528-rgnhfcbx	268	101	A(H1N1)pdm09	a(h1n1)pdm09	IN
cord-252528-rgnhfcbx	268	102	virus	virus	NN
cord-252528-rgnhfcbx	268	103	infected	infect	VBD
cord-252528-rgnhfcbx	268	104	population	population	NN
cord-252528-rgnhfcbx	268	105	of	of	IN
cord-252528-rgnhfcbx	268	106	Assam	Assam	NNP
cord-252528-rgnhfcbx	268	107	,	,	,
cord-252528-rgnhfcbx	268	108	Northeast	Northeast	NNP
cord-252528-rgnhfcbx	268	109	India	India	NNP
cord-252528-rgnhfcbx	268	110	Proteinase	Proteinase	NNP
cord-252528-rgnhfcbx	268	111	-	-	HYPH
cord-252528-rgnhfcbx	268	112	activated	activate	VBN
cord-252528-rgnhfcbx	268	113	receptors	receptor	NNS
cord-252528-rgnhfcbx	268	114	in	in	IN
cord-252528-rgnhfcbx	268	115	fibroproliferative	fibroproliferative	JJ
cord-252528-rgnhfcbx	268	116	lung	lung	NN
cord-252528-rgnhfcbx	268	117	disease	disease	NN
cord-252528-rgnhfcbx	268	118	Endothelial	endothelial	JJ
cord-252528-rgnhfcbx	268	119	cell	cell	NN
cord-252528-rgnhfcbx	268	120	infection	infection	NN
cord-252528-rgnhfcbx	268	121	and	and	CC
cord-252528-rgnhfcbx	268	122	endotheliitis	endotheliitis	NN
cord-252528-rgnhfcbx	268	123	in	in	IN
cord-252528-rgnhfcbx	268	124	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	268	125	Modulation	Modulation	NNP
cord-252528-rgnhfcbx	268	126	of	of	IN
cord-252528-rgnhfcbx	268	127	cytokine	cytokine	NN
cord-252528-rgnhfcbx	268	128	receptors	receptor	NNS
cord-252528-rgnhfcbx	268	129	by	by	IN
cord-252528-rgnhfcbx	268	130	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	268	131	broadly	broadly	RB
cord-252528-rgnhfcbx	268	132	regulates	regulate	VBZ
cord-252528-rgnhfcbx	268	133	differentiation	differentiation	NN
cord-252528-rgnhfcbx	268	134	into	into	IN
cord-252528-rgnhfcbx	268	135	helper	helper	NN
cord-252528-rgnhfcbx	268	136	T	t	NN
cord-252528-rgnhfcbx	268	137	cell	cell	NN
cord-252528-rgnhfcbx	268	138	lineages	lineage	NNS
cord-252528-rgnhfcbx	268	139	Priming	prime	VBG
cord-252528-rgnhfcbx	268	140	for	for	IN
cord-252528-rgnhfcbx	268	141	T	T	NNP
cord-252528-rgnhfcbx	268	142	helper	helper	NN
cord-252528-rgnhfcbx	268	143	type	type	NN
cord-252528-rgnhfcbx	268	144	2	2	CD
cord-252528-rgnhfcbx	268	145	differentiation	differentiation	NN
cord-252528-rgnhfcbx	268	146	by	by	IN
cord-252528-rgnhfcbx	268	147	interleukin	interleukin	NN
cord-252528-rgnhfcbx	268	148	2-mediated	2-mediated	CD
cord-252528-rgnhfcbx	268	149	induction	induction	NN
cord-252528-rgnhfcbx	268	150	of	of	IN
cord-252528-rgnhfcbx	268	151	interleukin	interleukin	NN
cord-252528-rgnhfcbx	268	152	4	4	CD
cord-252528-rgnhfcbx	268	153	receptor	receptor	NN
cord-252528-rgnhfcbx	268	154	alpha	alpha	NN
cord-252528-rgnhfcbx	268	155	-	-	HYPH
cord-252528-rgnhfcbx	268	156	chain	chain	NN
cord-252528-rgnhfcbx	268	157	expression	expression	NN
cord-252528-rgnhfcbx	269	1	An	an	DT
cord-252528-rgnhfcbx	269	2	essential	essential	JJ
cord-252528-rgnhfcbx	269	3	role	role	NN
cord-252528-rgnhfcbx	269	4	for	for	IN
cord-252528-rgnhfcbx	269	5	the	the	DT
cord-252528-rgnhfcbx	269	6	IL-2	IL-2	NNP
cord-252528-rgnhfcbx	269	7	receptor	receptor	NN
cord-252528-rgnhfcbx	269	8	in	in	IN
cord-252528-rgnhfcbx	269	9	T(reg	T(reg	NNP
cord-252528-rgnhfcbx	269	10	)	)	-RRB-
cord-252528-rgnhfcbx	270	1	cell	cell	NN
cord-252528-rgnhfcbx	270	2	function	function	NN
cord-252528-rgnhfcbx	270	3	Regulatory	Regulatory	NNP
cord-252528-rgnhfcbx	270	4	T	T	NNP
cord-252528-rgnhfcbx	270	5	cells	cell	NNS
cord-252528-rgnhfcbx	270	6	:	:	:
cord-252528-rgnhfcbx	270	7	mechanisms	mechanism	NNS
cord-252528-rgnhfcbx	270	8	of	of	IN
cord-252528-rgnhfcbx	270	9	differentiation	differentiation	NN
cord-252528-rgnhfcbx	270	10	and	and	CC
cord-252528-rgnhfcbx	270	11	function	function	NN
cord-252528-rgnhfcbx	270	12	Increased	increase	VBN
cord-252528-rgnhfcbx	270	13	secretion	secretion	NN
cord-252528-rgnhfcbx	270	14	of	of	IN
cord-252528-rgnhfcbx	270	15	urokinase	urokinase	NN
cord-252528-rgnhfcbx	270	16	-	-	HYPH
cord-252528-rgnhfcbx	270	17	type	type	NN
cord-252528-rgnhfcbx	270	18	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	270	19	activator	activator	NN
cord-252528-rgnhfcbx	270	20	by	by	IN
cord-252528-rgnhfcbx	270	21	human	human	JJ
cord-252528-rgnhfcbx	270	22	lung	lung	NN
cord-252528-rgnhfcbx	270	23	microvascular	microvascular	NN
cord-252528-rgnhfcbx	270	24	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	270	25	cells	cell	NNS
cord-252528-rgnhfcbx	271	1	Interleukin-2	interleukin-2	CC
cord-252528-rgnhfcbx	271	2	induces	induce	VBZ
cord-252528-rgnhfcbx	271	3	activation	activation	NN
cord-252528-rgnhfcbx	271	4	of	of	IN
cord-252528-rgnhfcbx	271	5	coagulation	coagulation	NN
cord-252528-rgnhfcbx	271	6	and	and	CC
cord-252528-rgnhfcbx	271	7	fibrinolysis	fibrinolysis	NN
cord-252528-rgnhfcbx	271	8	:	:	:
cord-252528-rgnhfcbx	272	1	resemblance	resemblance	NN
cord-252528-rgnhfcbx	272	2	to	to	IN
cord-252528-rgnhfcbx	272	3	the	the	DT
cord-252528-rgnhfcbx	272	4	changes	change	NNS
cord-252528-rgnhfcbx	272	5	seen	see	VBN
cord-252528-rgnhfcbx	272	6	during	during	IN
cord-252528-rgnhfcbx	272	7	experimental	experimental	JJ
cord-252528-rgnhfcbx	272	8	endotoxaemia	endotoxaemia	NN
cord-252528-rgnhfcbx	273	1	Interleukin	interleukin	NN
cord-252528-rgnhfcbx	273	2	2-mediated	2-mediated	CD
cord-252528-rgnhfcbx	274	1	immune	immune	JJ
cord-252528-rgnhfcbx	274	2	interferon	interferon	NNP
cord-252528-rgnhfcbx	275	1	(	(	-LRB-
cord-252528-rgnhfcbx	275	2	IFN	IFN	NNP
cord-252528-rgnhfcbx	275	3	-	-	HYPH
cord-252528-rgnhfcbx	275	4	gamma	gamma	NN
cord-252528-rgnhfcbx	275	5	)	)	-RRB-
cord-252528-rgnhfcbx	275	6	production	production	NN
cord-252528-rgnhfcbx	275	7	by	by	IN
cord-252528-rgnhfcbx	275	8	human	human	JJ
cord-252528-rgnhfcbx	275	9	T	T	NNP
cord-252528-rgnhfcbx	275	10	cells	cell	NNS
cord-252528-rgnhfcbx	275	11	and	and	CC
cord-252528-rgnhfcbx	275	12	T	t	NN
cord-252528-rgnhfcbx	275	13	cell	cell	NN
cord-252528-rgnhfcbx	275	14	subsets	subset	NNS
cord-252528-rgnhfcbx	275	15	Enhancement	Enhancement	NNP
cord-252528-rgnhfcbx	275	16	by	by	IN
cord-252528-rgnhfcbx	275	17	IL-1β	IL-1β	NNP
cord-252528-rgnhfcbx	275	18	and	and	CC
cord-252528-rgnhfcbx	275	19	IFN	IFN	NNP
cord-252528-rgnhfcbx	275	20	-	-	HYPH
cord-252528-rgnhfcbx	275	21	γ	γ	NNP
cord-252528-rgnhfcbx	275	22	of	of	IN
cord-252528-rgnhfcbx	275	23	platelet	platelet	NN
cord-252528-rgnhfcbx	275	24	activation	activation	NN
cord-252528-rgnhfcbx	275	25	:	:	:
cord-252528-rgnhfcbx	275	26	adhesion	adhesion	NN
cord-252528-rgnhfcbx	275	27	to	to	IN
cord-252528-rgnhfcbx	275	28	leukocytes	leukocyte	NNS
cord-252528-rgnhfcbx	275	29	via	via	IN
cord-252528-rgnhfcbx	275	30	GMP-140	GMP-140	NNP
cord-252528-rgnhfcbx	275	31	/	/	SYM
cord-252528-rgnhfcbx	275	32	padgem	padgem	NNP
cord-252528-rgnhfcbx	275	33	protein	protein	NN
cord-252528-rgnhfcbx	275	34	(	(	-LRB-
cord-252528-rgnhfcbx	275	35	CD62	CD62	NNP
cord-252528-rgnhfcbx	275	36	)	)	-RRB-
cord-252528-rgnhfcbx	275	37	Th1	th1	NN
cord-252528-rgnhfcbx	275	38	and	and	CC
cord-252528-rgnhfcbx	275	39	Th2	Th2	NNP
cord-252528-rgnhfcbx	275	40	T	T	NNP
cord-252528-rgnhfcbx	275	41	-	-	HYPH
cord-252528-rgnhfcbx	275	42	helper	helper	NN
cord-252528-rgnhfcbx	275	43	cells	cell	NNS
cord-252528-rgnhfcbx	275	44	exert	exert	VBP
cord-252528-rgnhfcbx	275	45	opposite	opposite	JJ
cord-252528-rgnhfcbx	275	46	regulatory	regulatory	JJ
cord-252528-rgnhfcbx	275	47	effects	effect	NNS
cord-252528-rgnhfcbx	275	48	on	on	IN
cord-252528-rgnhfcbx	275	49	procoagulant	procoagulant	NN
cord-252528-rgnhfcbx	275	50	activity	activity	NN
cord-252528-rgnhfcbx	275	51	and	and	CC
cord-252528-rgnhfcbx	275	52	tissue	tissue	NN
cord-252528-rgnhfcbx	275	53	factor	factor	NN
cord-252528-rgnhfcbx	275	54	production	production	NN
cord-252528-rgnhfcbx	275	55	by	by	IN
cord-252528-rgnhfcbx	275	56	human	human	JJ
cord-252528-rgnhfcbx	275	57	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	276	1	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	276	2	II	II	NNP
cord-252528-rgnhfcbx	276	3	-	-	HYPH
cord-252528-rgnhfcbx	276	4	induced	induce	VBN
cord-252528-rgnhfcbx	276	5	vascular	vascular	JJ
cord-252528-rgnhfcbx	276	6	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	276	7	depends	depend	VBZ
cord-252528-rgnhfcbx	276	8	on	on	IN
cord-252528-rgnhfcbx	276	9	interferon	interferon	NN
cord-252528-rgnhfcbx	276	10	-	-	HYPH
cord-252528-rgnhfcbx	276	11	γ	γ	NN
cord-252528-rgnhfcbx	276	12	-	-	HYPH
cord-252528-rgnhfcbx	276	13	driven	drive	VBN
cord-252528-rgnhfcbx	276	14	immune	immune	JJ
cord-252528-rgnhfcbx	276	15	cell	cell	NN
cord-252528-rgnhfcbx	276	16	recruitment	recruitment	NN
cord-252528-rgnhfcbx	276	17	and	and	CC
cord-252528-rgnhfcbx	276	18	mutual	mutual	JJ
cord-252528-rgnhfcbx	276	19	activation	activation	NN
cord-252528-rgnhfcbx	276	20	of	of	IN
cord-252528-rgnhfcbx	276	21	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	276	22	and	and	CC
cord-252528-rgnhfcbx	276	23	NK	nk	NN
cord-252528-rgnhfcbx	276	24	-	-	HYPH
cord-252528-rgnhfcbx	276	25	cells	cell	NNS
cord-252528-rgnhfcbx	277	1	Nitric	nitric	NN
cord-252528-rgnhfcbx	277	2	oxide	oxide	NN
cord-252528-rgnhfcbx	277	3	decreases	decrease	VBZ
cord-252528-rgnhfcbx	277	4	cytokine	cytokine	NN
cord-252528-rgnhfcbx	277	5	-	-	HYPH
cord-252528-rgnhfcbx	277	6	induced	induce	VBN
cord-252528-rgnhfcbx	277	7	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	277	8	activation	activation	NN
cord-252528-rgnhfcbx	277	9	.	.	.
cord-252528-rgnhfcbx	278	1	Nitric	nitric	NN
cord-252528-rgnhfcbx	278	2	oxide	oxide	NN
cord-252528-rgnhfcbx	278	3	selectively	selectively	RB
cord-252528-rgnhfcbx	278	4	reduces	reduce	VBZ
cord-252528-rgnhfcbx	278	5	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	278	6	expression	expression	NN
cord-252528-rgnhfcbx	278	7	of	of	IN
cord-252528-rgnhfcbx	278	8	adhesion	adhesion	NN
cord-252528-rgnhfcbx	278	9	molecules	molecule	NNS
cord-252528-rgnhfcbx	278	10	and	and	CC
cord-252528-rgnhfcbx	278	11	proinflammatory	proinflammatory	JJ
cord-252528-rgnhfcbx	278	12	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	279	1	Interferon	interferon	NN
cord-252528-rgnhfcbx	279	2	-	-	HYPH
cord-252528-rgnhfcbx	279	3	gamma	gamma	NN
cord-252528-rgnhfcbx	279	4	induced	induce	VBD
cord-252528-rgnhfcbx	279	5	adipose	adipose	JJ
cord-252528-rgnhfcbx	279	6	tissue	tissue	NN
cord-252528-rgnhfcbx	279	7	inflammation	inflammation	NN
cord-252528-rgnhfcbx	279	8	is	be	VBZ
cord-252528-rgnhfcbx	279	9	linked	link	VBN
cord-252528-rgnhfcbx	279	10	to	to	IN
cord-252528-rgnhfcbx	279	11	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	279	12	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	279	13	in	in	IN
cord-252528-rgnhfcbx	279	14	type	type	NN
cord-252528-rgnhfcbx	279	15	2	2	CD
cord-252528-rgnhfcbx	279	16	diabetic	diabetic	JJ
cord-252528-rgnhfcbx	279	17	mice	mouse	NNS
cord-252528-rgnhfcbx	279	18	Central	central	JJ
cord-252528-rgnhfcbx	279	19	role	role	NN
cord-252528-rgnhfcbx	279	20	of	of	IN
cord-252528-rgnhfcbx	279	21	the	the	DT
cord-252528-rgnhfcbx	279	22	P2Y12	P2Y12	NNP
cord-252528-rgnhfcbx	279	23	receptor	receptor	NN
cord-252528-rgnhfcbx	279	24	in	in	IN
cord-252528-rgnhfcbx	279	25	platelet	platelet	NN
cord-252528-rgnhfcbx	279	26	activation	activation	NN
cord-252528-rgnhfcbx	279	27	Platelet	platelet	NN
cord-252528-rgnhfcbx	279	28	interaction	interaction	NN
cord-252528-rgnhfcbx	279	29	with	with	IN
cord-252528-rgnhfcbx	279	30	activated	activate	VBN
cord-252528-rgnhfcbx	279	31	endothelium	endothelium	NN
cord-252528-rgnhfcbx	279	32	:	:	:
cord-252528-rgnhfcbx	279	33	mechanistic	mechanistic	JJ
cord-252528-rgnhfcbx	279	34	insights	insight	NNS
cord-252528-rgnhfcbx	279	35	from	from	IN
cord-252528-rgnhfcbx	279	36	microfluidics	microfluidic	NNS
cord-252528-rgnhfcbx	279	37	Natural	natural	JJ
cord-252528-rgnhfcbx	279	38	killer	killer	NN
cord-252528-rgnhfcbx	279	39	cells	cell	NNS
cord-252528-rgnhfcbx	279	40	induce	induce	VBP
cord-252528-rgnhfcbx	279	41	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	279	42	extracellular	extracellular	JJ
cord-252528-rgnhfcbx	279	43	trap	trap	NN
cord-252528-rgnhfcbx	279	44	formation	formation	NN
cord-252528-rgnhfcbx	279	45	in	in	IN
cord-252528-rgnhfcbx	279	46	venous	venous	JJ
cord-252528-rgnhfcbx	279	47	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	279	48	Absence	absence	NN
cord-252528-rgnhfcbx	279	49	of	of	IN
cord-252528-rgnhfcbx	279	50	IFN	IFN	NNP
cord-252528-rgnhfcbx	279	51	-	-	HYPH
cord-252528-rgnhfcbx	279	52	γ	γ	NNP
cord-252528-rgnhfcbx	279	53	accelerates	accelerate	VBZ
cord-252528-rgnhfcbx	279	54	thrombus	thrombus	NN
cord-252528-rgnhfcbx	279	55	resolution	resolution	NN
cord-252528-rgnhfcbx	279	56	through	through	IN
cord-252528-rgnhfcbx	279	57	enhanced	enhance	VBN
cord-252528-rgnhfcbx	279	58	MMP-9	MMP-9	NNP
cord-252528-rgnhfcbx	279	59	and	and	CC
cord-252528-rgnhfcbx	279	60	VEGF	VEGF	NNP
cord-252528-rgnhfcbx	279	61	expression	expression	NN
cord-252528-rgnhfcbx	279	62	in	in	IN
cord-252528-rgnhfcbx	279	63	mice	mice	NN
cord-252528-rgnhfcbx	279	64	Effects	effect	NNS
cord-252528-rgnhfcbx	279	65	of	of	IN
cord-252528-rgnhfcbx	279	66	IL-1β	il-1β	NN
cord-252528-rgnhfcbx	279	67	,	,	,
cord-252528-rgnhfcbx	279	68	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	279	69	and	and	CC
cord-252528-rgnhfcbx	279	70	IL-8	IL-8	NNP
cord-252528-rgnhfcbx	279	71	on	on	IN
cord-252528-rgnhfcbx	279	72	erythrocytes	erythrocyte	NNS
cord-252528-rgnhfcbx	279	73	Interleukin-6	Interleukin-6	NNP
cord-252528-rgnhfcbx	279	74	stimulates	stimulate	VBZ
cord-252528-rgnhfcbx	279	75	thrombopoiesis	thrombopoiesis	NN
cord-252528-rgnhfcbx	279	76	through	through	IN
cord-252528-rgnhfcbx	279	77	thrombopoietin	thrombopoietin	NNP
cord-252528-rgnhfcbx	279	78	:	:	:
cord-252528-rgnhfcbx	279	79	role	role	NN
cord-252528-rgnhfcbx	279	80	in	in	IN
cord-252528-rgnhfcbx	279	81	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	279	82	thrombocytosis	thrombocytosis	NN
cord-252528-rgnhfcbx	279	83	Porcine	Porcine	NNP
cord-252528-rgnhfcbx	279	84	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	279	85	,	,	,
cord-252528-rgnhfcbx	279	86	IL-1β	IL-1β	NNP
cord-252528-rgnhfcbx	279	87	,	,	,
cord-252528-rgnhfcbx	279	88	and	and	CC
cord-252528-rgnhfcbx	279	89	TNF	TNF	NNP
cord-252528-rgnhfcbx	279	90	-	-	HYPH
cord-252528-rgnhfcbx	279	91	α	α	NN
cord-252528-rgnhfcbx	279	92	regulate	regulate	VBP
cord-252528-rgnhfcbx	279	93	the	the	DT
cord-252528-rgnhfcbx	279	94	expression	expression	NN
cord-252528-rgnhfcbx	279	95	of	of	IN
cord-252528-rgnhfcbx	279	96	pro	pro	JJ
cord-252528-rgnhfcbx	279	97	-	-	JJ
cord-252528-rgnhfcbx	279	98	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	279	99	-	-	HYPH
cord-252528-rgnhfcbx	279	100	related	relate	VBN
cord-252528-rgnhfcbx	279	101	genes	gene	NNS
cord-252528-rgnhfcbx	279	102	and	and	CC
cord-252528-rgnhfcbx	279	103	tissue	tissue	NN
cord-252528-rgnhfcbx	279	104	factor	factor	NN
cord-252528-rgnhfcbx	279	105	in	in	IN
cord-252528-rgnhfcbx	279	106	human	human	JJ
cord-252528-rgnhfcbx	279	107	umbilical	umbilical	JJ
cord-252528-rgnhfcbx	279	108	vein	vein	NN
cord-252528-rgnhfcbx	279	109	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	279	110	cells	cell	NNS
cord-252528-rgnhfcbx	279	111	Effect	effect	NN
cord-252528-rgnhfcbx	279	112	of	of	IN
cord-252528-rgnhfcbx	279	113	human	human	JJ
cord-252528-rgnhfcbx	279	114	recombinant	recombinant	NN
cord-252528-rgnhfcbx	279	115	interleukin-6	interleukin-6	NNP
cord-252528-rgnhfcbx	279	116	and	and	CC
cord-252528-rgnhfcbx	279	117	interleukin-8	interleukin-8	NNP
cord-252528-rgnhfcbx	279	118	on	on	IN
cord-252528-rgnhfcbx	279	119	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	279	120	procoagulant	procoagulant	NNP
cord-252528-rgnhfcbx	279	121	activity	activity	NNP
cord-252528-rgnhfcbx	279	122	Elimination	Elimination	NNP
cord-252528-rgnhfcbx	279	123	of	of	IN
cord-252528-rgnhfcbx	279	124	interleukin	interleukin	NN
cord-252528-rgnhfcbx	279	125	6	6	CD
cord-252528-rgnhfcbx	280	1	attenuates	attenuate	VBZ
cord-252528-rgnhfcbx	280	2	coagulation	coagulation	NN
cord-252528-rgnhfcbx	280	3	activation	activation	NN
cord-252528-rgnhfcbx	280	4	in	in	IN
cord-252528-rgnhfcbx	280	5	experimental	experimental	JJ
cord-252528-rgnhfcbx	280	6	endotoxemia	endotoxemia	NN
cord-252528-rgnhfcbx	280	7	in	in	IN
cord-252528-rgnhfcbx	280	8	chimpanzees	chimpanzee	NNS
cord-252528-rgnhfcbx	280	9	Cytokine	cytokine	NN
cord-252528-rgnhfcbx	280	10	-	-	HYPH
cord-252528-rgnhfcbx	280	11	induced	induce	VBN
cord-252528-rgnhfcbx	280	12	alteration	alteration	NN
cord-252528-rgnhfcbx	280	13	of	of	IN
cord-252528-rgnhfcbx	280	14	platelet	platelet	NN
cord-252528-rgnhfcbx	280	15	and	and	CC
cord-252528-rgnhfcbx	280	16	hemostatic	hemostatic	JJ
cord-252528-rgnhfcbx	280	17	function	function	NN
cord-252528-rgnhfcbx	280	18	Role	role	NN
cord-252528-rgnhfcbx	280	19	of	of	IN
cord-252528-rgnhfcbx	280	20	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	280	21	and	and	CC
cord-252528-rgnhfcbx	280	22	its	-PRON-	PRP$
cord-252528-rgnhfcbx	280	23	soluble	soluble	JJ
cord-252528-rgnhfcbx	280	24	receptor	receptor	NN
cord-252528-rgnhfcbx	280	25	in	in	IN
cord-252528-rgnhfcbx	280	26	induction	induction	NN
cord-252528-rgnhfcbx	280	27	of	of	IN
cord-252528-rgnhfcbx	280	28	chemokines	chemokine	NNS
cord-252528-rgnhfcbx	280	29	and	and	CC
cord-252528-rgnhfcbx	280	30	leukocyte	leukocyte	NN
cord-252528-rgnhfcbx	280	31	recruitment	recruitment	NN
cord-252528-rgnhfcbx	280	32	Endothelial	Endothelial	NNP
cord-252528-rgnhfcbx	280	33	activation	activation	NN
cord-252528-rgnhfcbx	280	34	and	and	CC
cord-252528-rgnhfcbx	280	35	apoptosis	apoptosis	NN
cord-252528-rgnhfcbx	280	36	mediated	mediate	VBN
cord-252528-rgnhfcbx	280	37	by	by	IN
cord-252528-rgnhfcbx	280	38	neutrophil	neutrophil	NN
cord-252528-rgnhfcbx	280	39	-	-	HYPH
cord-252528-rgnhfcbx	280	40	dependent	dependent	JJ
cord-252528-rgnhfcbx	280	41	interleukin	interleukin	NN
cord-252528-rgnhfcbx	280	42	6	6	CD
cord-252528-rgnhfcbx	280	43	trans	trans	NN
cord-252528-rgnhfcbx	280	44	-	-	NN
cord-252528-rgnhfcbx	280	45	signalling	signalling	NN
cord-252528-rgnhfcbx	280	46	:	:	:
cord-252528-rgnhfcbx	280	47	a	a	DT
cord-252528-rgnhfcbx	280	48	novel	novel	JJ
cord-252528-rgnhfcbx	280	49	target	target	NN
cord-252528-rgnhfcbx	280	50	for	for	IN
cord-252528-rgnhfcbx	280	51	systemic	systemic	JJ
cord-252528-rgnhfcbx	280	52	sclerosis	sclerosis	NN
cord-252528-rgnhfcbx	280	53	?	?	.
cord-252528-rgnhfcbx	281	1	Crucial	crucial	JJ
cord-252528-rgnhfcbx	281	2	involvement	involvement	NN
cord-252528-rgnhfcbx	281	3	of	of	IN
cord-252528-rgnhfcbx	281	4	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	281	5	in	in	IN
cord-252528-rgnhfcbx	281	6	thrombus	thrombus	NN
cord-252528-rgnhfcbx	281	7	resolution	resolution	NN
cord-252528-rgnhfcbx	281	8	in	in	IN
cord-252528-rgnhfcbx	281	9	mice	mouse	NNS
cord-252528-rgnhfcbx	281	10	via	via	IN
cord-252528-rgnhfcbx	281	11	macrophage	macrophage	NN
cord-252528-rgnhfcbx	281	12	recruitment	recruitment	NN
cord-252528-rgnhfcbx	281	13	and	and	CC
cord-252528-rgnhfcbx	281	14	the	the	DT
cord-252528-rgnhfcbx	281	15	induction	induction	NN
cord-252528-rgnhfcbx	281	16	of	of	IN
cord-252528-rgnhfcbx	281	17	proteolytic	proteolytic	JJ
cord-252528-rgnhfcbx	281	18	enzymes	enzyme	NNS
cord-252528-rgnhfcbx	281	19	Inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	281	20	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	281	21	interleukin-6	interleukin-6	NNS
cord-252528-rgnhfcbx	281	22	and	and	CC
cord-252528-rgnhfcbx	281	23	oncostatin	oncostatin	NNS
cord-252528-rgnhfcbx	281	24	m	m	CD
cord-252528-rgnhfcbx	281	25	induce	induce	VBP
cord-252528-rgnhfcbx	281	26	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	281	27	activator	activator	NN
cord-252528-rgnhfcbx	281	28	inhibitor-1	inhibitor-1	NNP
cord-252528-rgnhfcbx	281	29	in	in	IN
cord-252528-rgnhfcbx	281	30	human	human	JJ
cord-252528-rgnhfcbx	281	31	adipose	adipose	NN
cord-252528-rgnhfcbx	281	32	tissue	tissue	NN
cord-252528-rgnhfcbx	281	33	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	281	34	:	:	:
cord-252528-rgnhfcbx	281	35	a	a	DT
cord-252528-rgnhfcbx	281	36	multifunctional	multifunctional	JJ
cord-252528-rgnhfcbx	281	37	cytokine	cytokine	NN
cord-252528-rgnhfcbx	281	38	in	in	IN
cord-252528-rgnhfcbx	281	39	viral	viral	JJ
cord-252528-rgnhfcbx	281	40	infections	infection	NNS
cord-252528-rgnhfcbx	281	41	Autocrine	Autocrine	NNP
cord-252528-rgnhfcbx	281	42	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	281	43	impairs	impair	VBZ
cord-252528-rgnhfcbx	281	44	dendritic	dendritic	JJ
cord-252528-rgnhfcbx	281	45	cell	cell	NN
cord-252528-rgnhfcbx	281	46	(	(	-LRB-
cord-252528-rgnhfcbx	281	47	DC)-derived	dc)-derived	CD
cord-252528-rgnhfcbx	281	48	immune	immune	JJ
cord-252528-rgnhfcbx	281	49	responses	response	NNS
cord-252528-rgnhfcbx	281	50	to	to	IN
cord-252528-rgnhfcbx	281	51	mycobacterial	mycobacterial	JJ
cord-252528-rgnhfcbx	281	52	infection	infection	NN
cord-252528-rgnhfcbx	281	53	by	by	IN
cord-252528-rgnhfcbx	281	54	suppressing	suppress	VBG
cord-252528-rgnhfcbx	281	55	DC	DC	NNP
cord-252528-rgnhfcbx	281	56	trafficking	traffic	VBG
cord-252528-rgnhfcbx	281	57	to	to	IN
cord-252528-rgnhfcbx	281	58	draining	drain	VBG
cord-252528-rgnhfcbx	281	59	lymph	lymph	NN
cord-252528-rgnhfcbx	281	60	nodes	node	NNS
cord-252528-rgnhfcbx	281	61	and	and	CC
cord-252528-rgnhfcbx	281	62	local	local	JJ
cord-252528-rgnhfcbx	281	63	IL-12	IL-12	NNP
cord-252528-rgnhfcbx	281	64	production	production	NN
cord-252528-rgnhfcbx	281	65	Anti	anti	JJ
cord-252528-rgnhfcbx	281	66	-	-	JJ
cord-252528-rgnhfcbx	281	67	inflammatory	inflammatory	JJ
cord-252528-rgnhfcbx	281	68	cytokines	cytokine	NNS
cord-252528-rgnhfcbx	281	69	IL-35	IL-35	NNP
cord-252528-rgnhfcbx	281	70	and	and	CC
cord-252528-rgnhfcbx	281	71	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	281	72	block	block	NN
cord-252528-rgnhfcbx	281	73	atherogenic	atherogenic	JJ
cord-252528-rgnhfcbx	281	74	lysophosphatidylcholine	lysophosphatidylcholine	NN
cord-252528-rgnhfcbx	281	75	-	-	HYPH
cord-252528-rgnhfcbx	281	76	induced	induce	VBN
cord-252528-rgnhfcbx	281	77	,	,	,
cord-252528-rgnhfcbx	281	78	mitochondrial	mitochondrial	JJ
cord-252528-rgnhfcbx	281	79	ROS	ROS	NNP
cord-252528-rgnhfcbx	281	80	-	-	HYPH
cord-252528-rgnhfcbx	281	81	mediated	mediate	VBN
cord-252528-rgnhfcbx	281	82	innate	innate	JJ
cord-252528-rgnhfcbx	281	83	immune	immune	JJ
cord-252528-rgnhfcbx	281	84	activation	activation	NN
cord-252528-rgnhfcbx	281	85	,	,	,
cord-252528-rgnhfcbx	281	86	but	but	CC
cord-252528-rgnhfcbx	281	87	spare	spare	JJ
cord-252528-rgnhfcbx	281	88	innate	innate	JJ
cord-252528-rgnhfcbx	281	89	immune	immune	JJ
cord-252528-rgnhfcbx	281	90	memory	memory	NN
cord-252528-rgnhfcbx	281	91	signature	signature	NN
cord-252528-rgnhfcbx	281	92	in	in	IN
cord-252528-rgnhfcbx	281	93	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	281	94	cells	cell	NNS
cord-252528-rgnhfcbx	281	95	IL-10	IL-10	NNP
cord-252528-rgnhfcbx	281	96	regulates	regulate	VBZ
cord-252528-rgnhfcbx	281	97	thrombus	thrombus	NN
cord-252528-rgnhfcbx	281	98	-	-	HYPH
cord-252528-rgnhfcbx	281	99	induced	induce	VBN
cord-252528-rgnhfcbx	281	100	vein	vein	NN
cord-252528-rgnhfcbx	281	101	wall	wall	NN
cord-252528-rgnhfcbx	281	102	inflammation	inflammation	NN
cord-252528-rgnhfcbx	281	103	and	and	CC
cord-252528-rgnhfcbx	281	104	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	281	105	Interleukin	Interleukin	NNP
cord-252528-rgnhfcbx	281	106	10-induced	10-induced	CD
cord-252528-rgnhfcbx	281	107	thrombocytopenia	thrombocytopenia	NN
cord-252528-rgnhfcbx	281	108	in	in	IN
cord-252528-rgnhfcbx	281	109	normal	normal	JJ
cord-252528-rgnhfcbx	281	110	healthy	healthy	JJ
cord-252528-rgnhfcbx	281	111	adult	adult	NN
cord-252528-rgnhfcbx	281	112	volunteers	volunteer	NNS
cord-252528-rgnhfcbx	281	113	:	:	:
cord-252528-rgnhfcbx	281	114	evidence	evidence	NN
cord-252528-rgnhfcbx	281	115	for	for	IN
cord-252528-rgnhfcbx	281	116	decreased	decreased	JJ
cord-252528-rgnhfcbx	281	117	platelet	platelet	NN
cord-252528-rgnhfcbx	281	118	production	production	NN
cord-252528-rgnhfcbx	282	1	In	in	IN
cord-252528-rgnhfcbx	282	2	patients	patient	NNS
cord-252528-rgnhfcbx	282	3	with	with	IN
cord-252528-rgnhfcbx	282	4	idiopathic	idiopathic	JJ
cord-252528-rgnhfcbx	282	5	venous	venous	JJ
cord-252528-rgnhfcbx	282	6	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	282	7	,	,	,
cord-252528-rgnhfcbx	282	8	interleukin-10	interleukin-10	NNP
cord-252528-rgnhfcbx	282	9	is	be	VBZ
cord-252528-rgnhfcbx	282	10	decreased	decrease	VBN
cord-252528-rgnhfcbx	282	11	and	and	CC
cord-252528-rgnhfcbx	282	12	related	relate	VBN
cord-252528-rgnhfcbx	282	13	to	to	IN
cord-252528-rgnhfcbx	282	14	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	282	15	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	283	1	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	283	2	infection	infection	NN
cord-252528-rgnhfcbx	283	3	:	:	:
cord-252528-rgnhfcbx	283	4	the	the	DT
cord-252528-rgnhfcbx	283	5	perspectives	perspective	NNS
cord-252528-rgnhfcbx	283	6	on	on	IN
cord-252528-rgnhfcbx	283	7	immune	immune	JJ
cord-252528-rgnhfcbx	283	8	responses	response	NNS
cord-252528-rgnhfcbx	283	9	The	the	DT
cord-252528-rgnhfcbx	283	10	cytokine	cytokine	NN
cord-252528-rgnhfcbx	283	11	storm	storm	NN
cord-252528-rgnhfcbx	283	12	of	of	IN
cord-252528-rgnhfcbx	283	13	severe	severe	JJ
cord-252528-rgnhfcbx	283	14	influenza	influenza	NN
cord-252528-rgnhfcbx	283	15	and	and	CC
cord-252528-rgnhfcbx	283	16	development	development	NN
cord-252528-rgnhfcbx	283	17	of	of	IN
cord-252528-rgnhfcbx	283	18	immunomodulatory	immunomodulatory	JJ
cord-252528-rgnhfcbx	283	19	therapy	therapy	NN
cord-252528-rgnhfcbx	283	20	Tocilizumab	tocilizumab	JJ
cord-252528-rgnhfcbx	283	21	treatment	treatment	NN
cord-252528-rgnhfcbx	283	22	in	in	IN
cord-252528-rgnhfcbx	283	23	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	283	24	:	:	:
cord-252528-rgnhfcbx	283	25	A	a	DT
cord-252528-rgnhfcbx	283	26	single	single	JJ
cord-252528-rgnhfcbx	283	27	center	center	NN
cord-252528-rgnhfcbx	283	28	experience	experience	NN
cord-252528-rgnhfcbx	283	29	Effective	effective	JJ
cord-252528-rgnhfcbx	283	30	treatment	treatment	NN
cord-252528-rgnhfcbx	283	31	of	of	IN
cord-252528-rgnhfcbx	283	32	severe	severe	JJ
cord-252528-rgnhfcbx	283	33	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	283	34	patients	patient	NNS
cord-252528-rgnhfcbx	283	35	with	with	IN
cord-252528-rgnhfcbx	283	36	tocilizumab	tocilizumab	JJ
cord-252528-rgnhfcbx	283	37	Clinical	clinical	JJ
cord-252528-rgnhfcbx	283	38	outcomes	outcome	NNS
cord-252528-rgnhfcbx	283	39	in	in	IN
cord-252528-rgnhfcbx	283	40	COVID-19	covid-19	JJ
cord-252528-rgnhfcbx	283	41	patients	patient	NNS
cord-252528-rgnhfcbx	283	42	treated	treat	VBN
cord-252528-rgnhfcbx	283	43	with	with	IN
cord-252528-rgnhfcbx	283	44	tocilizumab	tocilizumab	NNP
cord-252528-rgnhfcbx	283	45	:	:	:
cord-252528-rgnhfcbx	283	46	an	an	DT
cord-252528-rgnhfcbx	283	47	individual	individual	JJ
cord-252528-rgnhfcbx	283	48	patient	patient	NN
cord-252528-rgnhfcbx	283	49	data	datum	NNS
cord-252528-rgnhfcbx	283	50	systematic	systematic	JJ
cord-252528-rgnhfcbx	283	51	review	review	NN
cord-252528-rgnhfcbx	283	52	Low	Low	NNP
cord-252528-rgnhfcbx	283	53	dose	dose	NN
cord-252528-rgnhfcbx	283	54	of	of	IN
cord-252528-rgnhfcbx	283	55	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	283	56	reduces	reduce	VBZ
cord-252528-rgnhfcbx	283	57	fatality	fatality	NN
cord-252528-rgnhfcbx	283	58	of	of	IN
cord-252528-rgnhfcbx	283	59	critically	critically	RB
cord-252528-rgnhfcbx	283	60	ill	ill	JJ
cord-252528-rgnhfcbx	283	61	patients	patient	NNS
cord-252528-rgnhfcbx	283	62	with	with	IN
cord-252528-rgnhfcbx	283	63	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	283	64	Team	Team	NNP
cord-252528-rgnhfcbx	283	65	ftC-(2020	ftc-(2020	ADD
cord-252528-rgnhfcbx	283	66	)	)	-RRB-
cord-252528-rgnhfcbx	284	1	Effect	effect	NN
cord-252528-rgnhfcbx	284	2	of	of	IN
cord-252528-rgnhfcbx	284	3	high	high	JJ
cord-252528-rgnhfcbx	284	4	vs	vs	IN
cord-252528-rgnhfcbx	284	5	low	low	JJ
cord-252528-rgnhfcbx	284	6	doses	dose	NNS
cord-252528-rgnhfcbx	284	7	of	of	IN
cord-252528-rgnhfcbx	284	8	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	284	9	diphosphate	diphosphate	NN
cord-252528-rgnhfcbx	284	10	as	as	IN
cord-252528-rgnhfcbx	284	11	adjunctive	adjunctive	JJ
cord-252528-rgnhfcbx	284	12	therapy	therapy	NN
cord-252528-rgnhfcbx	284	13	for	for	IN
cord-252528-rgnhfcbx	284	14	patients	patient	NNS
cord-252528-rgnhfcbx	284	15	hospitalized	hospitalize	VBN
cord-252528-rgnhfcbx	284	16	with	with	IN
cord-252528-rgnhfcbx	284	17	severe	severe	JJ
cord-252528-rgnhfcbx	284	18	acute	acute	JJ
cord-252528-rgnhfcbx	284	19	respiratory	respiratory	JJ
cord-252528-rgnhfcbx	284	20	syndrome	syndrome	NN
cord-252528-rgnhfcbx	284	21	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	284	22	2	2	CD
cord-252528-rgnhfcbx	285	1	(	(	-LRB-
cord-252528-rgnhfcbx	285	2	SARS	SARS	NNP
cord-252528-rgnhfcbx	285	3	-	-	HYPH
cord-252528-rgnhfcbx	285	4	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	285	5	)	)	-RRB-
cord-252528-rgnhfcbx	285	6	infection	infection	NN
cord-252528-rgnhfcbx	285	7	:	:	:
cord-252528-rgnhfcbx	285	8	a	a	DT
cord-252528-rgnhfcbx	285	9	randomized	randomized	JJ
cord-252528-rgnhfcbx	285	10	clinical	clinical	JJ
cord-252528-rgnhfcbx	285	11	trial	trial	NN
cord-252528-rgnhfcbx	285	12	Chloroquine	Chloroquine	NNP
cord-252528-rgnhfcbx	285	13	and	and	CC
cord-252528-rgnhfcbx	285	14	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	285	15	equally	equally	RB
cord-252528-rgnhfcbx	285	16	affect	affect	VBP
cord-252528-rgnhfcbx	285	17	tumor	tumor	NN
cord-252528-rgnhfcbx	285	18	necrosis	necrosis	NN
cord-252528-rgnhfcbx	285	19	factor	factor	NN
cord-252528-rgnhfcbx	285	20	-	-	HYPH
cord-252528-rgnhfcbx	285	21	alpha	alpha	NN
cord-252528-rgnhfcbx	285	22	,	,	,
cord-252528-rgnhfcbx	285	23	interleukin	interleukin	NN
cord-252528-rgnhfcbx	285	24	6	6	CD
cord-252528-rgnhfcbx	285	25	,	,	,
cord-252528-rgnhfcbx	285	26	and	and	CC
cord-252528-rgnhfcbx	285	27	interferongamma	interferongamma	JJ
cord-252528-rgnhfcbx	285	28	production	production	NN
cord-252528-rgnhfcbx	285	29	by	by	IN
cord-252528-rgnhfcbx	285	30	peripheral	peripheral	JJ
cord-252528-rgnhfcbx	285	31	blood	blood	NN
cord-252528-rgnhfcbx	285	32	mononuclear	mononuclear	NN
cord-252528-rgnhfcbx	285	33	cells	cell	NNS
cord-252528-rgnhfcbx	285	34	Predictors	predictor	NNS
cord-252528-rgnhfcbx	285	35	of	of	IN
cord-252528-rgnhfcbx	285	36	major	major	JJ
cord-252528-rgnhfcbx	285	37	infections	infection	NNS
cord-252528-rgnhfcbx	285	38	in	in	IN
cord-252528-rgnhfcbx	285	39	systemic	systemic	JJ
cord-252528-rgnhfcbx	285	40	lupus	lupus	NN
cord-252528-rgnhfcbx	286	1	erythematosus	erythematosus	NNP
cord-252528-rgnhfcbx	286	2	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-252528-rgnhfcbx	286	3	reverses	reverse	VBZ
cord-252528-rgnhfcbx	286	4	platelet	platelet	NN
cord-252528-rgnhfcbx	286	5	activation	activation	NN
cord-252528-rgnhfcbx	286	6	induced	induce	VBN
cord-252528-rgnhfcbx	286	7	by	by	IN
cord-252528-rgnhfcbx	286	8	human	human	JJ
cord-252528-rgnhfcbx	286	9	IgG	IgG	NNP
cord-252528-rgnhfcbx	286	10	antiphospholipid	antiphospholipid	NNP
cord-252528-rgnhfcbx	286	11	antibodies	antibody	NNS
cord-252528-rgnhfcbx	286	12	On	on	IN
cord-252528-rgnhfcbx	286	13	the	the	DT
cord-252528-rgnhfcbx	286	14	inhibitory	inhibitory	JJ
cord-252528-rgnhfcbx	286	15	effect	effect	NN
cord-252528-rgnhfcbx	286	16	of	of	IN
cord-252528-rgnhfcbx	286	17	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	286	18	on	on	IN
cord-252528-rgnhfcbx	286	19	blood	blood	NN
cord-252528-rgnhfcbx	286	20	platelet	platelet	NN
cord-252528-rgnhfcbx	286	21	aggregation	aggregation	NN
cord-252528-rgnhfcbx	286	22	Prevention	Prevention	NNP
cord-252528-rgnhfcbx	286	23	of	of	IN
cord-252528-rgnhfcbx	286	24	postoperative	postoperative	JJ
cord-252528-rgnhfcbx	286	25	deep	deep	JJ
cord-252528-rgnhfcbx	286	26	venous	venous	JJ
cord-252528-rgnhfcbx	286	27	thrombosis	thrombosis	NN
cord-252528-rgnhfcbx	286	28	in	in	IN
cord-252528-rgnhfcbx	286	29	legs	leg	NNS
cord-252528-rgnhfcbx	286	30	by	by	IN
cord-252528-rgnhfcbx	286	31	orally	orally	RB
cord-252528-rgnhfcbx	286	32	administered	administer	VBN
cord-252528-rgnhfcbx	286	33	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	286	34	sulphate	sulphate	NN
cord-252528-rgnhfcbx	287	1	What	what	WP
cord-252528-rgnhfcbx	287	2	is	be	VBZ
cord-252528-rgnhfcbx	287	3	the	the	DT
cord-252528-rgnhfcbx	287	4	role	role	NN
cord-252528-rgnhfcbx	287	5	of	of	IN
cord-252528-rgnhfcbx	287	6	hydroxychloroquine	hydroxychloroquine	NN
cord-252528-rgnhfcbx	287	7	in	in	IN
cord-252528-rgnhfcbx	287	8	reducing	reduce	VBG
cord-252528-rgnhfcbx	287	9	thrombotic	thrombotic	JJ
cord-252528-rgnhfcbx	287	10	risk	risk	NN
cord-252528-rgnhfcbx	287	11	in	in	IN
cord-252528-rgnhfcbx	287	12	patients	patient	NNS
cord-252528-rgnhfcbx	287	13	with	with	IN
cord-252528-rgnhfcbx	287	14	antiphospholipid	antiphospholipid	NNP
cord-252528-rgnhfcbx	287	15	antibodies	antibody	NNS
cord-252528-rgnhfcbx	287	16	?	?	.
cord-252528-rgnhfcbx	288	1	Remdesivir	Remdesivir	NNP
cord-252528-rgnhfcbx	288	2	and	and	CC
cord-252528-rgnhfcbx	288	3	chloroquine	chloroquine	NN
cord-252528-rgnhfcbx	288	4	effectively	effectively	RB
cord-252528-rgnhfcbx	288	5	inhibit	inhibit	VBP
cord-252528-rgnhfcbx	288	6	the	the	DT
cord-252528-rgnhfcbx	288	7	recently	recently	RB
cord-252528-rgnhfcbx	288	8	emerged	emerge	VBN
cord-252528-rgnhfcbx	288	9	novel	novel	JJ
cord-252528-rgnhfcbx	288	10	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	288	11	(	(	-LRB-
cord-252528-rgnhfcbx	288	12	2019-nCoV	2019-ncov	CD
cord-252528-rgnhfcbx	288	13	)	)	-RRB-
cord-252528-rgnhfcbx	289	1	in	in	FW
cord-252528-rgnhfcbx	289	2	vitro	vitro	FW
cord-252528-rgnhfcbx	289	3	A	a	DT
cord-252528-rgnhfcbx	289	4	pneumonia	pneumonia	NN
cord-252528-rgnhfcbx	289	5	outbreak	outbreak	NN
cord-252528-rgnhfcbx	289	6	associated	associate	VBN
cord-252528-rgnhfcbx	289	7	with	with	IN
cord-252528-rgnhfcbx	289	8	a	a	DT
cord-252528-rgnhfcbx	289	9	new	new	JJ
cord-252528-rgnhfcbx	289	10	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	289	11	of	of	IN
cord-252528-rgnhfcbx	289	12	probable	probable	JJ
cord-252528-rgnhfcbx	289	13	bat	bat	NN
cord-252528-rgnhfcbx	289	14	origin	origin	NN
cord-252528-rgnhfcbx	289	15	Veesler	veesler	NN
cord-252528-rgnhfcbx	289	16	D	d	NN
cord-252528-rgnhfcbx	289	17	(	(	-LRB-
cord-252528-rgnhfcbx	289	18	2020	2020	CD
cord-252528-rgnhfcbx	289	19	)	)	-RRB-
cord-252528-rgnhfcbx	289	20	Structure	structure	NN
cord-252528-rgnhfcbx	289	21	,	,	,
cord-252528-rgnhfcbx	289	22	function	function	NN
cord-252528-rgnhfcbx	289	23	,	,	,
cord-252528-rgnhfcbx	289	24	and	and	CC
cord-252528-rgnhfcbx	289	25	antigenicity	antigenicity	NN
cord-252528-rgnhfcbx	289	26	of	of	IN
cord-252528-rgnhfcbx	289	27	the	the	DT
cord-252528-rgnhfcbx	289	28	SARS	SARS	NNP
cord-252528-rgnhfcbx	289	29	-	-	HYPH
cord-252528-rgnhfcbx	289	30	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	289	31	spike	spike	NN
cord-252528-rgnhfcbx	289	32	glycoprotein	glycoprotein	NN
cord-252528-rgnhfcbx	289	33	SARS	SARS	NNP
cord-252528-rgnhfcbx	289	34	-	-	HYPH
cord-252528-rgnhfcbx	289	35	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	289	36	Cell	cell	NN
cord-252528-rgnhfcbx	289	37	entry	entry	NN
cord-252528-rgnhfcbx	289	38	depends	depend	VBZ
cord-252528-rgnhfcbx	289	39	on	on	IN
cord-252528-rgnhfcbx	289	40	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	289	41	and	and	CC
cord-252528-rgnhfcbx	289	42	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	289	43	and	and	CC
cord-252528-rgnhfcbx	289	44	is	be	VBZ
cord-252528-rgnhfcbx	289	45	blocked	block	VBN
cord-252528-rgnhfcbx	289	46	by	by	IN
cord-252528-rgnhfcbx	289	47	a	a	DT
cord-252528-rgnhfcbx	289	48	clinically	clinically	RB
cord-252528-rgnhfcbx	289	49	proven	prove	VBN
cord-252528-rgnhfcbx	289	50	protease	protease	NN
cord-252528-rgnhfcbx	289	51	inhibitor	inhibitor	NN
cord-252528-rgnhfcbx	289	52	SARS	SARS	NNP
cord-252528-rgnhfcbx	289	53	-	-	HYPH
cord-252528-rgnhfcbx	289	54	CoV-2	CoV-2	NNP
cord-252528-rgnhfcbx	289	55	receptor	receptor	NN
cord-252528-rgnhfcbx	289	56	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	290	1	is	be	VBZ
cord-252528-rgnhfcbx	290	2	an	an	DT
cord-252528-rgnhfcbx	290	3	interferon	interferon	NN
cord-252528-rgnhfcbx	290	4	-	-	HYPH
cord-252528-rgnhfcbx	290	5	stimulated	stimulate	VBN
cord-252528-rgnhfcbx	290	6	gene	gene	NN
cord-252528-rgnhfcbx	290	7	in	in	IN
cord-252528-rgnhfcbx	290	8	human	human	JJ
cord-252528-rgnhfcbx	290	9	airway	airway	NN
cord-252528-rgnhfcbx	290	10	epithelial	epithelial	JJ
cord-252528-rgnhfcbx	290	11	cells	cell	NNS
cord-252528-rgnhfcbx	290	12	and	and	CC
cord-252528-rgnhfcbx	290	13	is	be	VBZ
cord-252528-rgnhfcbx	290	14	detected	detect	VBN
cord-252528-rgnhfcbx	290	15	in	in	IN
cord-252528-rgnhfcbx	290	16	specific	specific	JJ
cord-252528-rgnhfcbx	290	17	cell	cell	NN
cord-252528-rgnhfcbx	290	18	subsets	subset	NNS
cord-252528-rgnhfcbx	290	19	across	across	IN
cord-252528-rgnhfcbx	290	20	tissues	tissue	NNS
cord-252528-rgnhfcbx	290	21	Tissue	tissue	NN
cord-252528-rgnhfcbx	290	22	distribution	distribution	NN
cord-252528-rgnhfcbx	290	23	of	of	IN
cord-252528-rgnhfcbx	290	24	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	290	25	protein	protein	NN
cord-252528-rgnhfcbx	290	26	,	,	,
cord-252528-rgnhfcbx	290	27	the	the	DT
cord-252528-rgnhfcbx	290	28	functional	functional	JJ
cord-252528-rgnhfcbx	290	29	receptor	receptor	NN
cord-252528-rgnhfcbx	290	30	for	for	IN
cord-252528-rgnhfcbx	290	31	SARS	SARS	NNP
cord-252528-rgnhfcbx	290	32	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	290	33	.	.	.
cord-252528-rgnhfcbx	291	1	A	a	DT
cord-252528-rgnhfcbx	291	2	first	first	JJ
cord-252528-rgnhfcbx	291	3	step	step	NN
cord-252528-rgnhfcbx	291	4	in	in	IN
cord-252528-rgnhfcbx	291	5	understanding	understand	VBG
cord-252528-rgnhfcbx	291	6	SARS	SARS	NNP
cord-252528-rgnhfcbx	291	7	pathogenesis	pathogenesis	NN
cord-252528-rgnhfcbx	292	1	A	a	DT
cord-252528-rgnhfcbx	292	2	crucial	crucial	JJ
cord-252528-rgnhfcbx	292	3	role	role	NN
cord-252528-rgnhfcbx	292	4	of	of	IN
cord-252528-rgnhfcbx	292	5	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	292	6	converting	convert	VBG
cord-252528-rgnhfcbx	292	7	enzyme	enzyme	NN
cord-252528-rgnhfcbx	292	8	2	2	CD
cord-252528-rgnhfcbx	292	9	(	(	-LRB-
cord-252528-rgnhfcbx	292	10	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	292	11	)	)	-RRB-
cord-252528-rgnhfcbx	292	12	in	in	IN
cord-252528-rgnhfcbx	292	13	SARS	SARS	NNP
cord-252528-rgnhfcbx	292	14	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	292	15	-	-	HYPH
cord-252528-rgnhfcbx	292	16	induced	induce	VBN
cord-252528-rgnhfcbx	292	17	lung	lung	NN
cord-252528-rgnhfcbx	292	18	injury	injury	NN
cord-252528-rgnhfcbx	292	19	SARS	SARS	NNP
cord-252528-rgnhfcbx	292	20	-	-	HYPH
cord-252528-rgnhfcbx	292	21	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	292	22	modulation	modulation	NN
cord-252528-rgnhfcbx	292	23	of	of	IN
cord-252528-rgnhfcbx	292	24	myocardial	myocardial	JJ
cord-252528-rgnhfcbx	292	25	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	292	26	expression	expression	NN
cord-252528-rgnhfcbx	292	27	and	and	CC
cord-252528-rgnhfcbx	292	28	inflammation	inflammation	NN
cord-252528-rgnhfcbx	292	29	in	in	IN
cord-252528-rgnhfcbx	292	30	patients	patient	NNS
cord-252528-rgnhfcbx	292	31	with	with	IN
cord-252528-rgnhfcbx	292	32	SARS	SARS	NNP
cord-252528-rgnhfcbx	292	33	Modulation	Modulation	NNP
cord-252528-rgnhfcbx	292	34	of	of	IN
cord-252528-rgnhfcbx	292	35	TNF	TNF	NNP
cord-252528-rgnhfcbx	292	36	-	-	HYPH
cord-252528-rgnhfcbx	292	37	alpha	alpha	NN
cord-252528-rgnhfcbx	292	38	-	-	HYPH
cord-252528-rgnhfcbx	292	39	converting	convert	VBG
cord-252528-rgnhfcbx	292	40	enzyme	enzyme	NN
cord-252528-rgnhfcbx	292	41	by	by	IN
cord-252528-rgnhfcbx	292	42	the	the	DT
cord-252528-rgnhfcbx	292	43	spike	spike	NN
cord-252528-rgnhfcbx	292	44	protein	protein	NN
cord-252528-rgnhfcbx	292	45	of	of	IN
cord-252528-rgnhfcbx	292	46	SARS	SARS	NNP
cord-252528-rgnhfcbx	292	47	-	-	HYPH
cord-252528-rgnhfcbx	292	48	CoV	CoV	NNP
cord-252528-rgnhfcbx	292	49	and	and	CC
cord-252528-rgnhfcbx	292	50	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	292	51	induces	induce	VBZ
cord-252528-rgnhfcbx	292	52	TNF	tnf	NN
cord-252528-rgnhfcbx	292	53	-	-	HYPH
cord-252528-rgnhfcbx	292	54	alpha	alpha	NN
cord-252528-rgnhfcbx	292	55	production	production	NN
cord-252528-rgnhfcbx	292	56	and	and	CC
cord-252528-rgnhfcbx	292	57	facilitates	facilitate	VBZ
cord-252528-rgnhfcbx	292	58	viral	viral	JJ
cord-252528-rgnhfcbx	292	59	entry	entry	NN
cord-252528-rgnhfcbx	292	60	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	293	1	and	and	CC
cord-252528-rgnhfcbx	293	2	ADAM17	adam17	UH
cord-252528-rgnhfcbx	293	3	cleave	cleave	VB
cord-252528-rgnhfcbx	293	4	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	293	5	differentially	differentially	RB
cord-252528-rgnhfcbx	294	1	and	and	CC
cord-252528-rgnhfcbx	294	2	only	only	JJ
cord-252528-rgnhfcbx	294	3	proteolysis	proteolysis	NN
cord-252528-rgnhfcbx	294	4	by	by	IN
cord-252528-rgnhfcbx	294	5	TMPRSS2	TMPRSS2	NNP
cord-252528-rgnhfcbx	294	6	augments	augment	VBZ
cord-252528-rgnhfcbx	294	7	entry	entry	NN
cord-252528-rgnhfcbx	294	8	driven	drive	VBN
cord-252528-rgnhfcbx	294	9	by	by	IN
cord-252528-rgnhfcbx	294	10	the	the	DT
cord-252528-rgnhfcbx	294	11	severe	severe	JJ
cord-252528-rgnhfcbx	294	12	acute	acute	JJ
cord-252528-rgnhfcbx	294	13	respiratory	respiratory	JJ
cord-252528-rgnhfcbx	294	14	syndrome	syndrome	NN
cord-252528-rgnhfcbx	294	15	coronavirus	coronavirus	NN
cord-252528-rgnhfcbx	294	16	spike	spike	NN
cord-252528-rgnhfcbx	294	17	protein	protein	NN
cord-252528-rgnhfcbx	294	18	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	294	19	II	II	NNP
cord-252528-rgnhfcbx	294	20	increases	increase	VBZ
cord-252528-rgnhfcbx	294	21	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	294	22	activator	activator	NN
cord-252528-rgnhfcbx	294	23	inhibitor	inhibitor	NN
cord-252528-rgnhfcbx	294	24	type	type	NN
cord-252528-rgnhfcbx	294	25	1	1	CD
cord-252528-rgnhfcbx	294	26	and	and	CC
cord-252528-rgnhfcbx	294	27	tissue	tissue	NN
cord-252528-rgnhfcbx	294	28	-	-	HYPH
cord-252528-rgnhfcbx	294	29	type	type	NN
cord-252528-rgnhfcbx	294	30	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	294	31	activator	activator	NN
cord-252528-rgnhfcbx	294	32	messenger	messenger	NN
cord-252528-rgnhfcbx	294	33	RNA	RNA	NNP
cord-252528-rgnhfcbx	294	34	in	in	IN
cord-252528-rgnhfcbx	294	35	cultured	cultured	JJ
cord-252528-rgnhfcbx	294	36	rat	rat	NN
cord-252528-rgnhfcbx	294	37	aortic	aortic	JJ
cord-252528-rgnhfcbx	294	38	smooth	smooth	JJ
cord-252528-rgnhfcbx	294	39	muscle	muscle	NN
cord-252528-rgnhfcbx	294	40	cells	cell	NNS
cord-252528-rgnhfcbx	294	41	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	294	42	II	II	NNP
cord-252528-rgnhfcbx	294	43	increases	increase	VBZ
cord-252528-rgnhfcbx	294	44	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	294	45	activator	activator	NN
cord-252528-rgnhfcbx	294	46	inhibitor-1	inhibitor-1	NNP
cord-252528-rgnhfcbx	294	47	and	and	CC
cord-252528-rgnhfcbx	294	48	tissue	tissue	NN
cord-252528-rgnhfcbx	294	49	factor	factor	NN
cord-252528-rgnhfcbx	295	1	mRNA	mrna	NN
cord-252528-rgnhfcbx	295	2	expression	expression	NN
cord-252528-rgnhfcbx	295	3	without	without	IN
cord-252528-rgnhfcbx	295	4	changing	change	VBG
cord-252528-rgnhfcbx	295	5	that	that	DT
cord-252528-rgnhfcbx	295	6	of	of	IN
cord-252528-rgnhfcbx	295	7	tissue	tissue	NN
cord-252528-rgnhfcbx	295	8	type	type	NN
cord-252528-rgnhfcbx	295	9	plasminogen	plasminogen	NN
cord-252528-rgnhfcbx	295	10	activator	activator	NN
cord-252528-rgnhfcbx	295	11	or	or	CC
cord-252528-rgnhfcbx	295	12	tissue	tissue	NN
cord-252528-rgnhfcbx	295	13	factor	factor	NN
cord-252528-rgnhfcbx	295	14	pathway	pathway	NN
cord-252528-rgnhfcbx	295	15	inhibitor	inhibitor	NN
cord-252528-rgnhfcbx	295	16	in	in	IN
cord-252528-rgnhfcbx	295	17	cultured	cultured	JJ
cord-252528-rgnhfcbx	295	18	rat	rat	NN
cord-252528-rgnhfcbx	295	19	aortic	aortic	JJ
cord-252528-rgnhfcbx	295	20	endothelial	endothelial	NN
cord-252528-rgnhfcbx	295	21	cells	cell	NNS
cord-252528-rgnhfcbx	295	22	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	295	23	II	II	NNP
cord-252528-rgnhfcbx	295	24	stimulates	stimulate	VBZ
cord-252528-rgnhfcbx	295	25	NADH	NADH	NNP
cord-252528-rgnhfcbx	295	26	and	and	CC
cord-252528-rgnhfcbx	295	27	NADPH	NADPH	NNP
cord-252528-rgnhfcbx	295	28	oxidase	oxidase	NN
cord-252528-rgnhfcbx	295	29	activity	activity	NN
cord-252528-rgnhfcbx	295	30	in	in	IN
cord-252528-rgnhfcbx	295	31	cultured	cultured	JJ
cord-252528-rgnhfcbx	295	32	vascular	vascular	JJ
cord-252528-rgnhfcbx	295	33	smooth	smooth	JJ
cord-252528-rgnhfcbx	295	34	muscle	muscle	NN
cord-252528-rgnhfcbx	295	35	cells	cell	NNS
cord-252528-rgnhfcbx	295	36	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	295	37	activation	activation	NN
cord-252528-rgnhfcbx	295	38	promotes	promote	VBZ
cord-252528-rgnhfcbx	295	39	antithrombotic	antithrombotic	JJ
cord-252528-rgnhfcbx	295	40	activity	activity	NN
cord-252528-rgnhfcbx	296	1	The	the	DT
cord-252528-rgnhfcbx	296	2	effects	effect	NNS
cord-252528-rgnhfcbx	296	3	of	of	IN
cord-252528-rgnhfcbx	296	4	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	296	5	metabolites	metabolite	NNS
cord-252528-rgnhfcbx	296	6	on	on	IN
cord-252528-rgnhfcbx	296	7	the	the	DT
cord-252528-rgnhfcbx	296	8	regulation	regulation	NN
cord-252528-rgnhfcbx	296	9	of	of	IN
cord-252528-rgnhfcbx	296	10	coagulation	coagulation	NN
cord-252528-rgnhfcbx	296	11	and	and	CC
cord-252528-rgnhfcbx	296	12	fibrinolysis	fibrinolysis	NN
cord-252528-rgnhfcbx	296	13	in	in	IN
cord-252528-rgnhfcbx	296	14	cultured	cultured	JJ
cord-252528-rgnhfcbx	296	15	rat	rat	NN
cord-252528-rgnhfcbx	296	16	aortic	aortic	JJ
cord-252528-rgnhfcbx	296	17	endothelial	endothelial	NN
cord-252528-rgnhfcbx	296	18	cells	cell	NNS
cord-252528-rgnhfcbx	296	19	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	296	20	internalization	internalization	NN
cord-252528-rgnhfcbx	296	21	and	and	CC
cord-252528-rgnhfcbx	296	22	degradation	degradation	NN
cord-252528-rgnhfcbx	296	23	is	be	VBZ
cord-252528-rgnhfcbx	296	24	controlled	control	VBN
cord-252528-rgnhfcbx	296	25	by	by	IN
cord-252528-rgnhfcbx	296	26	ubiquitin	ubiquitin	NN
cord-252528-rgnhfcbx	296	27	ligase	ligase	NN
cord-252528-rgnhfcbx	296	28	NEDD4	NEDD4	NNP
cord-252528-rgnhfcbx	297	1	The	the	DT
cord-252528-rgnhfcbx	297	2	antithrombotic	antithrombotic	JJ
cord-252528-rgnhfcbx	297	3	effect	effect	NN
cord-252528-rgnhfcbx	297	4	of	of	IN
cord-252528-rgnhfcbx	297	5	angiotensin-(1	angiotensin-(1	CD
cord-252528-rgnhfcbx	297	6	-	-	SYM
cord-252528-rgnhfcbx	297	7	7	7	CD
cord-252528-rgnhfcbx	297	8	)	)	-RRB-
cord-252528-rgnhfcbx	297	9	involves	involve	VBZ
cord-252528-rgnhfcbx	297	10	mas	mas	NNP
cord-252528-rgnhfcbx	297	11	-	-	HYPH
cord-252528-rgnhfcbx	297	12	mediated	mediate	VBN
cord-252528-rgnhfcbx	297	13	NO	no	DT
cord-252528-rgnhfcbx	297	14	release	release	NN
cord-252528-rgnhfcbx	297	15	from	from	IN
cord-252528-rgnhfcbx	297	16	platelets	platelet	NNS
cord-252528-rgnhfcbx	297	17	MAP	MAP	NNP
cord-252528-rgnhfcbx	297	18	kinase/	kinase/	WDT
cord-252528-rgnhfcbx	297	19	phosphatase	phosphatase	NN
cord-252528-rgnhfcbx	297	20	pathway	pathway	NN
cord-252528-rgnhfcbx	298	1	mediates	mediate	VBZ
cord-252528-rgnhfcbx	298	2	the	the	DT
cord-252528-rgnhfcbx	298	3	regulation	regulation	NN
cord-252528-rgnhfcbx	298	4	of	of	IN
cord-252528-rgnhfcbx	298	5	ACE2	ACE2	NNP
cord-252528-rgnhfcbx	298	6	by	by	IN
cord-252528-rgnhfcbx	298	7	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	298	8	peptides	peptide	NNS
cord-252528-rgnhfcbx	298	9	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	298	10	II	II	NNP
cord-252528-rgnhfcbx	298	11	-	-	HYPH
cord-252528-rgnhfcbx	298	12	induced	induce	VBN
cord-252528-rgnhfcbx	298	13	vascular	vascular	JJ
cord-252528-rgnhfcbx	298	14	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	298	15	depends	depend	VBZ
cord-252528-rgnhfcbx	298	16	on	on	IN
cord-252528-rgnhfcbx	298	17	interferon	interferon	NN
cord-252528-rgnhfcbx	298	18	-	-	HYPH
cord-252528-rgnhfcbx	298	19	gamma	gamma	NN
cord-252528-rgnhfcbx	298	20	-	-	HYPH
cord-252528-rgnhfcbx	298	21	driven	drive	VBN
cord-252528-rgnhfcbx	298	22	immune	immune	JJ
cord-252528-rgnhfcbx	298	23	cell	cell	NN
cord-252528-rgnhfcbx	298	24	recruitment	recruitment	NN
cord-252528-rgnhfcbx	298	25	and	and	CC
cord-252528-rgnhfcbx	298	26	mutual	mutual	JJ
cord-252528-rgnhfcbx	298	27	activation	activation	NN
cord-252528-rgnhfcbx	298	28	of	of	IN
cord-252528-rgnhfcbx	298	29	monocytes	monocyte	NNS
cord-252528-rgnhfcbx	298	30	and	and	CC
cord-252528-rgnhfcbx	298	31	NK	nk	NN
cord-252528-rgnhfcbx	298	32	-	-	HYPH
cord-252528-rgnhfcbx	298	33	cells	cell	NNS
cord-252528-rgnhfcbx	298	34	Novel	novel	JJ
cord-252528-rgnhfcbx	298	35	role	role	NN
cord-252528-rgnhfcbx	298	36	of	of	IN
cord-252528-rgnhfcbx	298	37	T	t	NN
cord-252528-rgnhfcbx	298	38	cells	cell	NNS
cord-252528-rgnhfcbx	298	39	and	and	CC
cord-252528-rgnhfcbx	298	40	IL-6	IL-6	NNP
cord-252528-rgnhfcbx	298	41	(	(	-LRB-
cord-252528-rgnhfcbx	298	42	Interleukin-6	Interleukin-6	NNP
cord-252528-rgnhfcbx	298	43	)	)	-RRB-
cord-252528-rgnhfcbx	298	44	in	in	IN
cord-252528-rgnhfcbx	298	45	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	298	46	II	II	NNP
cord-252528-rgnhfcbx	298	47	-	-	HYPH
cord-252528-rgnhfcbx	298	48	induced	induce	VBN
cord-252528-rgnhfcbx	298	49	microvascular	microvascular	JJ
cord-252528-rgnhfcbx	298	50	dysfunction	dysfunction	NN
cord-252528-rgnhfcbx	298	51	Comparative	comparative	JJ
cord-252528-rgnhfcbx	298	52	effects	effect	NNS
cord-252528-rgnhfcbx	298	53	of	of	IN
cord-252528-rgnhfcbx	298	54	AT1-antagonism	at1-antagonism	NN
cord-252528-rgnhfcbx	298	55	and	and	CC
cord-252528-rgnhfcbx	298	56	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	298	57	-	-	HYPH
cord-252528-rgnhfcbx	298	58	converting	convert	VBG
cord-252528-rgnhfcbx	298	59	enzyme	enzyme	NN
cord-252528-rgnhfcbx	298	60	inhibition	inhibition	NN
cord-252528-rgnhfcbx	298	61	on	on	IN
cord-252528-rgnhfcbx	298	62	markers	marker	NNS
cord-252528-rgnhfcbx	298	63	of	of	IN
cord-252528-rgnhfcbx	298	64	inflammation	inflammation	NN
cord-252528-rgnhfcbx	298	65	and	and	CC
cord-252528-rgnhfcbx	298	66	platelet	platelet	NN
cord-252528-rgnhfcbx	298	67	aggregation	aggregation	NN
cord-252528-rgnhfcbx	298	68	in	in	IN
cord-252528-rgnhfcbx	298	69	patients	patient	NNS
cord-252528-rgnhfcbx	298	70	with	with	IN
cord-252528-rgnhfcbx	298	71	coronary	coronary	JJ
cord-252528-rgnhfcbx	298	72	artery	artery	NN
cord-252528-rgnhfcbx	298	73	disease	disease	NN
cord-252528-rgnhfcbx	298	74	ACEI	ACEI	NNP
cord-252528-rgnhfcbx	298	75	/	/	SYM
cord-252528-rgnhfcbx	298	76	ARB	ARB	NNP
cord-252528-rgnhfcbx	298	77	use	use	NN
cord-252528-rgnhfcbx	298	78	and	and	CC
cord-252528-rgnhfcbx	298	79	risk	risk	NN
cord-252528-rgnhfcbx	298	80	of	of	IN
cord-252528-rgnhfcbx	298	81	infection	infection	NN
cord-252528-rgnhfcbx	298	82	or	or	CC
cord-252528-rgnhfcbx	298	83	severity	severity	NN
cord-252528-rgnhfcbx	298	84	or	or	CC
cord-252528-rgnhfcbx	298	85	mortality	mortality	NN
cord-252528-rgnhfcbx	298	86	of	of	IN
cord-252528-rgnhfcbx	298	87	COVID-19	covid-19	NN
cord-252528-rgnhfcbx	298	88	:	:	:
cord-252528-rgnhfcbx	299	1	a	a	DT
cord-252528-rgnhfcbx	299	2	systematic	systematic	JJ
cord-252528-rgnhfcbx	299	3	review	review	NN
cord-252528-rgnhfcbx	299	4	and	and	CC
cord-252528-rgnhfcbx	299	5	meta	meta	NNP
cord-252528-rgnhfcbx	299	6	-	-	HYPH
cord-252528-rgnhfcbx	299	7	analysis	analysis	NNP
cord-252528-rgnhfcbx	299	8	Association	Association	NNP
cord-252528-rgnhfcbx	299	9	of	of	IN
cord-252528-rgnhfcbx	299	10	inpatient	inpatient	JJ
cord-252528-rgnhfcbx	299	11	use	use	NN
cord-252528-rgnhfcbx	299	12	of	of	IN
cord-252528-rgnhfcbx	299	13	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	299	14	-	-	HYPH
cord-252528-rgnhfcbx	299	15	converting	convert	VBG
cord-252528-rgnhfcbx	299	16	enzyme	enzyme	NN
cord-252528-rgnhfcbx	299	17	inhibitors	inhibitor	NNS
cord-252528-rgnhfcbx	299	18	and	and	CC
cord-252528-rgnhfcbx	299	19	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	299	20	II	ii	CD
cord-252528-rgnhfcbx	299	21	receptor	receptor	NN
cord-252528-rgnhfcbx	299	22	blockers	blocker	NNS
cord-252528-rgnhfcbx	299	23	with	with	IN
cord-252528-rgnhfcbx	299	24	mortality	mortality	NN
cord-252528-rgnhfcbx	299	25	among	among	IN
cord-252528-rgnhfcbx	299	26	patients	patient	NNS
cord-252528-rgnhfcbx	299	27	with	with	IN
cord-252528-rgnhfcbx	299	28	hypertension	hypertension	NN
cord-252528-rgnhfcbx	299	29	hospitalized	hospitalize	VBN
cord-252528-rgnhfcbx	299	30	with	with	IN
cord-252528-rgnhfcbx	299	31	COVID-19	COVID-19	NNP
cord-252528-rgnhfcbx	299	32	ACE	ACE	NNP
cord-252528-rgnhfcbx	299	33	inhibitor	inhibitor	NN
cord-252528-rgnhfcbx	299	34	quinapril	quinapril	NNP
cord-252528-rgnhfcbx	299	35	reduces	reduce	VBZ
cord-252528-rgnhfcbx	299	36	the	the	DT
cord-252528-rgnhfcbx	299	37	arterial	arterial	JJ
cord-252528-rgnhfcbx	299	38	expression	expression	NN
cord-252528-rgnhfcbx	299	39	of	of	IN
cord-252528-rgnhfcbx	299	40	NF	NF	NNP
cord-252528-rgnhfcbx	299	41	-	-	HYPH
cord-252528-rgnhfcbx	299	42	kappaB	kappaB	NNP
cord-252528-rgnhfcbx	299	43	-	-	HYPH
cord-252528-rgnhfcbx	299	44	dependent	dependent	JJ
cord-252528-rgnhfcbx	299	45	proinflammatory	proinflammatory	JJ
cord-252528-rgnhfcbx	299	46	factors	factor	NNS
cord-252528-rgnhfcbx	299	47	but	but	CC
cord-252528-rgnhfcbx	299	48	not	not	RB
cord-252528-rgnhfcbx	299	49	of	of	IN
cord-252528-rgnhfcbx	299	50	collagen	collagen	NN
cord-252528-rgnhfcbx	299	51	I	-PRON-	PRP
cord-252528-rgnhfcbx	299	52	in	in	IN
cord-252528-rgnhfcbx	299	53	a	a	DT
cord-252528-rgnhfcbx	299	54	rabbit	rabbit	NN
cord-252528-rgnhfcbx	299	55	model	model	NN
cord-252528-rgnhfcbx	299	56	of	of	IN
cord-252528-rgnhfcbx	299	57	atherosclerosis	atherosclerosis	NN
cord-252528-rgnhfcbx	299	58	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	299	59	-	-	HYPH
cord-252528-rgnhfcbx	299	60	converting	convert	VBG
cord-252528-rgnhfcbx	299	61	enzyme	enzyme	NN
cord-252528-rgnhfcbx	299	62	inhibition	inhibition	NN
cord-252528-rgnhfcbx	299	63	prevents	prevent	VBZ
cord-252528-rgnhfcbx	299	64	arterial	arterial	JJ
cord-252528-rgnhfcbx	299	65	nuclear	nuclear	JJ
cord-252528-rgnhfcbx	299	66	factor	factor	NN
cord-252528-rgnhfcbx	299	67	-	-	HYPH
cord-252528-rgnhfcbx	299	68	kappa	kappa	NN
cord-252528-rgnhfcbx	299	69	B	B	NNP
cord-252528-rgnhfcbx	299	70	activation	activation	NN
cord-252528-rgnhfcbx	299	71	,	,	,
cord-252528-rgnhfcbx	299	72	monocyte	monocyte	NNP
cord-252528-rgnhfcbx	299	73	chemoattractant	chemoattractant	NNP
cord-252528-rgnhfcbx	299	74	protein-1	protein-1	NNP
cord-252528-rgnhfcbx	299	75	expression	expression	NN
cord-252528-rgnhfcbx	299	76	,	,	,
cord-252528-rgnhfcbx	299	77	and	and	CC
cord-252528-rgnhfcbx	299	78	macrophage	macrophage	NN
cord-252528-rgnhfcbx	299	79	infiltration	infiltration	NN
cord-252528-rgnhfcbx	299	80	in	in	IN
cord-252528-rgnhfcbx	299	81	a	a	DT
cord-252528-rgnhfcbx	299	82	rabbit	rabbit	NN
cord-252528-rgnhfcbx	299	83	model	model	NN
cord-252528-rgnhfcbx	299	84	of	of	IN
cord-252528-rgnhfcbx	299	85	early	early	JJ
cord-252528-rgnhfcbx	299	86	accelerated	accelerated	JJ
cord-252528-rgnhfcbx	299	87	atherosclerosis	atherosclerosis	NN
cord-252528-rgnhfcbx	299	88	ACE	ACE	NNP
cord-252528-rgnhfcbx	299	89	inhibitors	inhibitor	NNS
cord-252528-rgnhfcbx	299	90	potently	potently	RB
cord-252528-rgnhfcbx	299	91	reduce	reduce	VBP
cord-252528-rgnhfcbx	299	92	vascular	vascular	JJ
cord-252528-rgnhfcbx	299	93	inflammation	inflammation	NN
cord-252528-rgnhfcbx	299	94	,	,	,
cord-252528-rgnhfcbx	299	95	results	result	NNS
cord-252528-rgnhfcbx	299	96	of	of	IN
cord-252528-rgnhfcbx	299	97	an	an	DT
cord-252528-rgnhfcbx	299	98	open	open	JJ
cord-252528-rgnhfcbx	299	99	proof	proof	NN
cord-252528-rgnhfcbx	299	100	-	-	HYPH
cord-252528-rgnhfcbx	299	101	of	of	IN
cord-252528-rgnhfcbx	299	102	-	-	HYPH
cord-252528-rgnhfcbx	299	103	concept	concept	NN
cord-252528-rgnhfcbx	299	104	study	study	NN
cord-252528-rgnhfcbx	299	105	in	in	IN
cord-252528-rgnhfcbx	299	106	the	the	DT
cord-252528-rgnhfcbx	299	107	abdominal	abdominal	JJ
cord-252528-rgnhfcbx	299	108	aortic	aortic	JJ
cord-252528-rgnhfcbx	299	109	aneurysm	aneurysm	NN
cord-252528-rgnhfcbx	299	110	Angiotensin	Angiotensin	NNP
cord-252528-rgnhfcbx	299	111	II	II	NNP
cord-252528-rgnhfcbx	299	112	-	-	HYPH
cord-252528-rgnhfcbx	299	113	mediated	mediate	VBN
cord-252528-rgnhfcbx	299	114	hypertension	hypertension	NN
cord-252528-rgnhfcbx	299	115	in	in	IN
cord-252528-rgnhfcbx	299	116	the	the	DT
cord-252528-rgnhfcbx	299	117	rat	rat	NN
cord-252528-rgnhfcbx	299	118	increases	increase	VBZ
cord-252528-rgnhfcbx	299	119	vascular	vascular	JJ
cord-252528-rgnhfcbx	299	120	superoxide	superoxide	NN
cord-252528-rgnhfcbx	299	121	production	production	NN
cord-252528-rgnhfcbx	299	122	via	via	IN
cord-252528-rgnhfcbx	299	123	membrane	membrane	NN
cord-252528-rgnhfcbx	299	124	NADH	NADH	NNP
cord-252528-rgnhfcbx	299	125	/	/	SYM
cord-252528-rgnhfcbx	299	126	NADPH	NADPH	NNP
cord-252528-rgnhfcbx	299	127	oxidase	oxidase	NN
cord-252528-rgnhfcbx	299	128	activation	activation	NN
cord-252528-rgnhfcbx	299	129	.	.	.
cord-252528-rgnhfcbx	300	1	Contribution	contribution	NN
cord-252528-rgnhfcbx	300	2	to	to	IN
cord-252528-rgnhfcbx	300	3	alterations	alteration	NNS
cord-252528-rgnhfcbx	300	4	of	of	IN
cord-252528-rgnhfcbx	300	5	vasomotor	vasomotor	NN
cord-252528-rgnhfcbx	300	6	tone	tone	NN
cord-252528-rgnhfcbx	300	7	Losartan	Losartan	NNP
cord-252528-rgnhfcbx	300	8	reduces	reduce	VBZ
cord-252528-rgnhfcbx	300	9	phenylephrine	phenylephrine	JJ
cord-252528-rgnhfcbx	300	10	constrictor	constrictor	NN
cord-252528-rgnhfcbx	300	11	response	response	NN
cord-252528-rgnhfcbx	300	12	in	in	IN
cord-252528-rgnhfcbx	300	13	aortic	aortic	JJ
cord-252528-rgnhfcbx	300	14	rings	ring	NNS
cord-252528-rgnhfcbx	300	15	from	from	IN
cord-252528-rgnhfcbx	300	16	spontaneously	spontaneously	RB
cord-252528-rgnhfcbx	300	17	hypertensive	hypertensive	JJ
cord-252528-rgnhfcbx	300	18	rats	rat	NNS
cord-252528-rgnhfcbx	301	1	Role	role	NN
cord-252528-rgnhfcbx	301	2	of	of	IN
cord-252528-rgnhfcbx	301	3	nitric	nitric	NN
cord-252528-rgnhfcbx	301	4	oxide	oxide	NN
cord-252528-rgnhfcbx	301	5	and	and	CC
cord-252528-rgnhfcbx	301	6	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	301	7	II	ii	CD
cord-252528-rgnhfcbx	301	8	type	type	NN
cord-252528-rgnhfcbx	301	9	2	2	CD
cord-252528-rgnhfcbx	301	10	receptors	receptor	NNS
cord-252528-rgnhfcbx	302	1	The	the	DT
cord-252528-rgnhfcbx	302	2	possible	possible	JJ
cord-252528-rgnhfcbx	302	3	role	role	NN
cord-252528-rgnhfcbx	302	4	of	of	IN
cord-252528-rgnhfcbx	302	5	angiotensin	angiotensin	NN
cord-252528-rgnhfcbx	302	6	II	II	NNP
cord-252528-rgnhfcbx	302	7	subtype	subtype	NN
cord-252528-rgnhfcbx	302	8	AT2	at2	NN
cord-252528-rgnhfcbx	302	9	receptors	receptor	NNS
cord-252528-rgnhfcbx	302	10	in	in	IN
cord-252528-rgnhfcbx	302	11	endothelial	endothelial	JJ
cord-252528-rgnhfcbx	302	12	cells	cell	NNS
cord-252528-rgnhfcbx	302	13	and	and	CC
cord-252528-rgnhfcbx	302	14	isolated	isolate	VBN
cord-252528-rgnhfcbx	302	15	ischemic	ischemic	JJ
cord-252528-rgnhfcbx	302	16	rat	rat	NN
cord-252528-rgnhfcbx	302	17	hearts	heart	NNS
cord-252528-rgnhfcbx	303	1	Publisher	publisher	NN
cord-252528-rgnhfcbx	303	2	's	's	POS
cord-252528-rgnhfcbx	303	3	Note	Note	NNP
cord-252528-rgnhfcbx	303	4	Springer	Springer	NNP
cord-252528-rgnhfcbx	303	5	Nature	Nature	NNP
cord-252528-rgnhfcbx	303	6	remains	remain	VBZ
cord-252528-rgnhfcbx	303	7	neutral	neutral	JJ
cord-252528-rgnhfcbx	303	8	with	with	IN
cord-252528-rgnhfcbx	303	9	regard	regard	NN
cord-252528-rgnhfcbx	303	10	to	to	IN
cord-252528-rgnhfcbx	303	11	jurisdictional	jurisdictional	JJ
cord-252528-rgnhfcbx	303	12	claims	claim	NNS
cord-252528-rgnhfcbx	303	13	in	in	IN
cord-252528-rgnhfcbx	303	14	published	publish	VBN
cord-252528-rgnhfcbx	303	15	maps	map	NNS
cord-252528-rgnhfcbx	303	16	and	and	CC
cord-252528-rgnhfcbx	303	17	institutional	institutional	JJ
cord-252528-rgnhfcbx	303	18	affiliations	affiliation	NNS
cord-252528-rgnhfcbx	303	19	.	.	.