id	sid	tid	token	lemma	pos
cord-312386-88uwlmjx	1	1	key	key	NN
cord-312386-88uwlmjx	1	2	:	:	:
cord-312386-88uwlmjx	2	1	cord-312386	cord-312386	NNP
cord-312386-88uwlmjx	2	2	-	-	HYPH
cord-312386-88uwlmjx	2	3	88uwlmjx	88uwlmjx	CD
cord-312386-88uwlmjx	2	4	authors	author	NNS
cord-312386-88uwlmjx	2	5	:	:	:
cord-312386-88uwlmjx	2	6	Kuchipudi	Kuchipudi	NNP
cord-312386-88uwlmjx	2	7	,	,	,
cord-312386-88uwlmjx	2	8	Suresh	Suresh	NNP
cord-312386-88uwlmjx	2	9	V.	V.	NNP
cord-312386-88uwlmjx	2	10	title	title	NN
cord-312386-88uwlmjx	2	11	:	:	:
cord-312386-88uwlmjx	2	12	The	the	DT
cord-312386-88uwlmjx	2	13	Complex	Complex	NNP
cord-312386-88uwlmjx	2	14	Role	role	NN
cord-312386-88uwlmjx	2	15	of	of	IN
cord-312386-88uwlmjx	2	16	STAT3	STAT3	NNP
cord-312386-88uwlmjx	2	17	in	in	IN
cord-312386-88uwlmjx	2	18	Viral	Viral	NNP
cord-312386-88uwlmjx	2	19	Infections	Infections	NNPS
cord-312386-88uwlmjx	2	20	date	date	NN
cord-312386-88uwlmjx	2	21	:	:	:
cord-312386-88uwlmjx	2	22	2015	2015	CD
cord-312386-88uwlmjx	2	23	-	-	HYPH
cord-312386-88uwlmjx	2	24	06	06	CD
cord-312386-88uwlmjx	2	25	-	-	SYM
cord-312386-88uwlmjx	2	26	25	25	CD
cord-312386-88uwlmjx	2	27	journal	journal	NN
cord-312386-88uwlmjx	2	28	:	:	:
cord-312386-88uwlmjx	2	29	J	J	NNP
cord-312386-88uwlmjx	2	30	Immunol	Immunol	NNP
cord-312386-88uwlmjx	2	31	Res	Res	HYPH
cord-312386-88uwlmjx	2	32	DOI	doi	NN
cord-312386-88uwlmjx	2	33	:	:	:
cord-312386-88uwlmjx	2	34	10.1155/2015/272359	10.1155/2015/272359	CD
cord-312386-88uwlmjx	2	35	sha	sha	NNP
cord-312386-88uwlmjx	2	36	:	:	:
cord-312386-88uwlmjx	2	37	db0761035838151a0b08a13888982ee36641b467	db0761035838151a0b08a13888982ee36641b467	NNP
cord-312386-88uwlmjx	2	38	doc_id	doc_id	CD
cord-312386-88uwlmjx	2	39	:	:	:
cord-312386-88uwlmjx	2	40	312386	312386	CD
cord-312386-88uwlmjx	2	41	cord_uid	cord_uid	NNS
cord-312386-88uwlmjx	2	42	:	:	:
cord-312386-88uwlmjx	2	43	88uwlmjx	88uwlmjx	LS
cord-312386-88uwlmjx	2	44	Signal	signal	NN
cord-312386-88uwlmjx	2	45	transducer	transducer	NN
cord-312386-88uwlmjx	2	46	and	and	CC
cord-312386-88uwlmjx	2	47	activators	activator	NNS
cord-312386-88uwlmjx	2	48	of	of	IN
cord-312386-88uwlmjx	2	49	transcription-3	transcription-3	NN
cord-312386-88uwlmjx	2	50	(	(	-LRB-
cord-312386-88uwlmjx	2	51	STAT3	STAT3	NNP
cord-312386-88uwlmjx	2	52	)	)	-RRB-
cord-312386-88uwlmjx	2	53	regulates	regulate	VBZ
cord-312386-88uwlmjx	2	54	diverse	diverse	JJ
cord-312386-88uwlmjx	2	55	biological	biological	JJ
cord-312386-88uwlmjx	2	56	functions	function	NNS
cord-312386-88uwlmjx	2	57	including	include	VBG
cord-312386-88uwlmjx	2	58	cell	cell	NN
cord-312386-88uwlmjx	2	59	growth	growth	NN
cord-312386-88uwlmjx	2	60	,	,	,
cord-312386-88uwlmjx	2	61	differentiation	differentiation	NN
cord-312386-88uwlmjx	2	62	,	,	,
cord-312386-88uwlmjx	2	63	and	and	CC
cord-312386-88uwlmjx	2	64	apoptosis	apoptosis	NN
cord-312386-88uwlmjx	2	65	.	.	.
cord-312386-88uwlmjx	3	1	In	in	IN
cord-312386-88uwlmjx	3	2	addition	addition	NN
cord-312386-88uwlmjx	3	3	,	,	,
cord-312386-88uwlmjx	3	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	3	5	plays	play	VBZ
cord-312386-88uwlmjx	3	6	a	a	DT
cord-312386-88uwlmjx	3	7	key	key	JJ
cord-312386-88uwlmjx	3	8	role	role	NN
cord-312386-88uwlmjx	3	9	in	in	IN
cord-312386-88uwlmjx	3	10	regulating	regulate	VBG
cord-312386-88uwlmjx	3	11	host	host	NN
cord-312386-88uwlmjx	3	12	immune	immune	JJ
cord-312386-88uwlmjx	3	13	and	and	CC
cord-312386-88uwlmjx	3	14	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	3	15	responses	response	NNS
cord-312386-88uwlmjx	3	16	and	and	CC
cord-312386-88uwlmjx	3	17	in	in	IN
cord-312386-88uwlmjx	3	18	the	the	DT
cord-312386-88uwlmjx	3	19	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	3	20	of	of	IN
cord-312386-88uwlmjx	3	21	many	many	JJ
cord-312386-88uwlmjx	3	22	cancers	cancer	NNS
cord-312386-88uwlmjx	3	23	.	.	.
cord-312386-88uwlmjx	4	1	Several	several	JJ
cord-312386-88uwlmjx	4	2	studies	study	NNS
cord-312386-88uwlmjx	4	3	reported	report	VBD
cord-312386-88uwlmjx	4	4	differential	differential	JJ
cord-312386-88uwlmjx	4	5	regulation	regulation	NN
cord-312386-88uwlmjx	4	6	of	of	IN
cord-312386-88uwlmjx	4	7	STAT3	STAT3	NNP
cord-312386-88uwlmjx	4	8	in	in	IN
cord-312386-88uwlmjx	4	9	a	a	DT
cord-312386-88uwlmjx	4	10	range	range	NN
cord-312386-88uwlmjx	4	11	of	of	IN
cord-312386-88uwlmjx	4	12	viral	viral	JJ
cord-312386-88uwlmjx	4	13	infections	infection	NNS
cord-312386-88uwlmjx	4	14	.	.	.
cord-312386-88uwlmjx	5	1	Interestingly	interestingly	RB
cord-312386-88uwlmjx	5	2	,	,	,
cord-312386-88uwlmjx	5	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	5	4	appears	appear	VBZ
cord-312386-88uwlmjx	5	5	to	to	TO
cord-312386-88uwlmjx	5	6	direct	direct	VB
cord-312386-88uwlmjx	5	7	seemingly	seemingly	RB
cord-312386-88uwlmjx	5	8	contradictory	contradictory	JJ
cord-312386-88uwlmjx	5	9	responses	response	NNS
cord-312386-88uwlmjx	5	10	and	and	CC
cord-312386-88uwlmjx	5	11	both	both	CC
cord-312386-88uwlmjx	5	12	pro-	pro-	JJ
cord-312386-88uwlmjx	5	13	and	and	CC
cord-312386-88uwlmjx	5	14	antiviral	antiviral	JJ
cord-312386-88uwlmjx	5	15	roles	role	NNS
cord-312386-88uwlmjx	5	16	of	of	IN
cord-312386-88uwlmjx	5	17	STAT3	STAT3	NNP
cord-312386-88uwlmjx	5	18	have	have	VBP
cord-312386-88uwlmjx	5	19	been	be	VBN
cord-312386-88uwlmjx	5	20	described	describe	VBN
cord-312386-88uwlmjx	5	21	.	.	.
cord-312386-88uwlmjx	6	1	This	this	DT
cord-312386-88uwlmjx	6	2	review	review	NN
cord-312386-88uwlmjx	6	3	summarized	summarize	VBD
cord-312386-88uwlmjx	6	4	the	the	DT
cord-312386-88uwlmjx	6	5	currently	currently	RB
cord-312386-88uwlmjx	6	6	known	know	VBN
cord-312386-88uwlmjx	6	7	functions	function	NNS
cord-312386-88uwlmjx	6	8	of	of	IN
cord-312386-88uwlmjx	6	9	STAT3	STAT3	NNP
cord-312386-88uwlmjx	6	10	in	in	IN
cord-312386-88uwlmjx	6	11	the	the	DT
cord-312386-88uwlmjx	6	12	regulation	regulation	NN
cord-312386-88uwlmjx	6	13	of	of	IN
cord-312386-88uwlmjx	6	14	viral	viral	JJ
cord-312386-88uwlmjx	6	15	replication	replication	NN
cord-312386-88uwlmjx	6	16	and	and	CC
cord-312386-88uwlmjx	6	17	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	6	18	of	of	IN
cord-312386-88uwlmjx	6	19	viral	viral	JJ
cord-312386-88uwlmjx	6	20	infections	infection	NNS
cord-312386-88uwlmjx	6	21	.	.	.
cord-312386-88uwlmjx	7	1	Some	some	DT
cord-312386-88uwlmjx	7	2	of	of	IN
cord-312386-88uwlmjx	7	3	the	the	DT
cord-312386-88uwlmjx	7	4	key	key	JJ
cord-312386-88uwlmjx	7	5	unanswered	unanswered	JJ
cord-312386-88uwlmjx	7	6	questions	question	NNS
cord-312386-88uwlmjx	7	7	and	and	CC
cord-312386-88uwlmjx	7	8	the	the	DT
cord-312386-88uwlmjx	7	9	gap	gap	NN
cord-312386-88uwlmjx	7	10	in	in	IN
cord-312386-88uwlmjx	7	11	our	-PRON-	PRP$
cord-312386-88uwlmjx	7	12	current	current	JJ
cord-312386-88uwlmjx	7	13	understanding	understanding	NN
cord-312386-88uwlmjx	7	14	of	of	IN
cord-312386-88uwlmjx	7	15	the	the	DT
cord-312386-88uwlmjx	7	16	role	role	NN
cord-312386-88uwlmjx	7	17	of	of	IN
cord-312386-88uwlmjx	7	18	STAT3	STAT3	NNP
cord-312386-88uwlmjx	7	19	in	in	IN
cord-312386-88uwlmjx	7	20	viral	viral	JJ
cord-312386-88uwlmjx	7	21	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	7	22	are	be	VBP
cord-312386-88uwlmjx	7	23	discussed	discuss	VBN
cord-312386-88uwlmjx	7	24	.	.	.
cord-312386-88uwlmjx	8	1	Signal	signal	NN
cord-312386-88uwlmjx	8	2	transducers	transducer	NNS
cord-312386-88uwlmjx	8	3	and	and	CC
cord-312386-88uwlmjx	8	4	activators	activator	NNS
cord-312386-88uwlmjx	8	5	of	of	IN
cord-312386-88uwlmjx	8	6	transcription	transcription	NN
cord-312386-88uwlmjx	8	7	(	(	-LRB-
cord-312386-88uwlmjx	8	8	STATs	stat	NNS
cord-312386-88uwlmjx	8	9	)	)	-RRB-
cord-312386-88uwlmjx	8	10	are	be	VBP
cord-312386-88uwlmjx	8	11	a	a	DT
cord-312386-88uwlmjx	8	12	family	family	NN
cord-312386-88uwlmjx	8	13	of	of	IN
cord-312386-88uwlmjx	8	14	transcription	transcription	NN
cord-312386-88uwlmjx	8	15	factors	factor	NNS
cord-312386-88uwlmjx	8	16	that	that	WDT
cord-312386-88uwlmjx	8	17	play	play	VBP
cord-312386-88uwlmjx	8	18	crucial	crucial	JJ
cord-312386-88uwlmjx	8	19	roles	role	NNS
cord-312386-88uwlmjx	8	20	in	in	IN
cord-312386-88uwlmjx	8	21	regulating	regulate	VBG
cord-312386-88uwlmjx	8	22	a	a	DT
cord-312386-88uwlmjx	8	23	number	number	NN
cord-312386-88uwlmjx	8	24	of	of	IN
cord-312386-88uwlmjx	8	25	diverse	diverse	JJ
cord-312386-88uwlmjx	8	26	biological	biological	JJ
cord-312386-88uwlmjx	8	27	functions	function	NNS
cord-312386-88uwlmjx	8	28	including	include	VBG
cord-312386-88uwlmjx	8	29	cell	cell	NN
cord-312386-88uwlmjx	8	30	proliferation	proliferation	NN
cord-312386-88uwlmjx	8	31	,	,	,
cord-312386-88uwlmjx	8	32	differentiation	differentiation	NN
cord-312386-88uwlmjx	8	33	,	,	,
cord-312386-88uwlmjx	8	34	apoptosis	apoptosis	NN
cord-312386-88uwlmjx	8	35	,	,	,
cord-312386-88uwlmjx	8	36	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	8	37	response	response	NN
cord-312386-88uwlmjx	8	38	,	,	,
cord-312386-88uwlmjx	8	39	immunity	immunity	NN
cord-312386-88uwlmjx	8	40	,	,	,
cord-312386-88uwlmjx	8	41	and	and	CC
cord-312386-88uwlmjx	8	42	angiogenesis	angiogenesis	NN
cord-312386-88uwlmjx	8	43	[	[	-LRB-
cord-312386-88uwlmjx	8	44	1	1	CD
cord-312386-88uwlmjx	8	45	]	]	-RRB-
cord-312386-88uwlmjx	8	46	.	.	.
cord-312386-88uwlmjx	9	1	There	there	EX
cord-312386-88uwlmjx	9	2	are	be	VBP
cord-312386-88uwlmjx	9	3	seven	seven	CD
cord-312386-88uwlmjx	9	4	STAT	stat	NN
cord-312386-88uwlmjx	9	5	proteins	protein	NNS
cord-312386-88uwlmjx	9	6	(	(	-LRB-
cord-312386-88uwlmjx	9	7	STATs	stat	NNS
cord-312386-88uwlmjx	9	8	1	1	CD
cord-312386-88uwlmjx	9	9	,	,	,
cord-312386-88uwlmjx	9	10	2	2	CD
cord-312386-88uwlmjx	9	11	,	,	,
cord-312386-88uwlmjx	9	12	3	3	CD
cord-312386-88uwlmjx	9	13	,	,	,
cord-312386-88uwlmjx	9	14	4	4	CD
cord-312386-88uwlmjx	9	15	,	,	,
cord-312386-88uwlmjx	9	16	5a	5a	CD
cord-312386-88uwlmjx	9	17	,	,	,
cord-312386-88uwlmjx	9	18	5b	5b	NN
cord-312386-88uwlmjx	9	19	,	,	,
cord-312386-88uwlmjx	9	20	and	and	CC
cord-312386-88uwlmjx	9	21	6	6	CD
cord-312386-88uwlmjx	9	22	)	)	-RRB-
cord-312386-88uwlmjx	9	23	,	,	,
cord-312386-88uwlmjx	9	24	which	which	WDT
cord-312386-88uwlmjx	9	25	are	be	VBP
cord-312386-88uwlmjx	9	26	activated	activate	VBN
cord-312386-88uwlmjx	9	27	by	by	IN
cord-312386-88uwlmjx	9	28	the	the	DT
cord-312386-88uwlmjx	9	29	signals	signal	NNS
cord-312386-88uwlmjx	9	30	from	from	IN
cord-312386-88uwlmjx	9	31	cytokine	cytokine	NN
cord-312386-88uwlmjx	9	32	and	and	CC
cord-312386-88uwlmjx	9	33	growth	growth	NN
cord-312386-88uwlmjx	9	34	factor	factor	NN
cord-312386-88uwlmjx	9	35	receptors	receptor	NNS
cord-312386-88uwlmjx	9	36	in	in	IN
cord-312386-88uwlmjx	9	37	the	the	DT
cord-312386-88uwlmjx	9	38	plasma	plasma	NN
cord-312386-88uwlmjx	9	39	membrane	membrane	NN
cord-312386-88uwlmjx	9	40	and	and	CC
cord-312386-88uwlmjx	9	41	regulate	regulate	VB
cord-312386-88uwlmjx	9	42	gene	gene	NN
cord-312386-88uwlmjx	9	43	transcription	transcription	NN
cord-312386-88uwlmjx	9	44	[	[	-LRB-
cord-312386-88uwlmjx	9	45	2	2	CD
cord-312386-88uwlmjx	9	46	]	]	-RRB-
cord-312386-88uwlmjx	9	47	.	.	.
cord-312386-88uwlmjx	10	1	A	a	DT
cord-312386-88uwlmjx	10	2	unique	unique	JJ
cord-312386-88uwlmjx	10	3	feature	feature	NN
cord-312386-88uwlmjx	10	4	of	of	IN
cord-312386-88uwlmjx	10	5	STAT	stat	NN
cord-312386-88uwlmjx	10	6	proteins	protein	NNS
cord-312386-88uwlmjx	10	7	is	be	VBZ
cord-312386-88uwlmjx	10	8	their	-PRON-	PRP$
cord-312386-88uwlmjx	10	9	dual	dual	JJ
cord-312386-88uwlmjx	10	10	roles	role	NNS
cord-312386-88uwlmjx	10	11	,	,	,
cord-312386-88uwlmjx	10	12	which	which	WDT
cord-312386-88uwlmjx	10	13	include	include	VBP
cord-312386-88uwlmjx	10	14	signal	signal	NN
cord-312386-88uwlmjx	10	15	transduction	transduction	NN
cord-312386-88uwlmjx	10	16	through	through	IN
cord-312386-88uwlmjx	10	17	the	the	DT
cord-312386-88uwlmjx	10	18	cytoplasm	cytoplasm	NN
cord-312386-88uwlmjx	10	19	and	and	CC
cord-312386-88uwlmjx	10	20	functioning	function	VBG
cord-312386-88uwlmjx	10	21	as	as	IN
cord-312386-88uwlmjx	10	22	transcription	transcription	NN
cord-312386-88uwlmjx	10	23	factors	factor	NNS
cord-312386-88uwlmjx	10	24	in	in	IN
cord-312386-88uwlmjx	10	25	the	the	DT
cord-312386-88uwlmjx	10	26	nucleus	nucleus	NN
cord-312386-88uwlmjx	10	27	[	[	-LRB-
cord-312386-88uwlmjx	10	28	3	3	CD
cord-312386-88uwlmjx	10	29	]	]	-RRB-
cord-312386-88uwlmjx	10	30	[	[	-LRB-
cord-312386-88uwlmjx	10	31	4	4	CD
cord-312386-88uwlmjx	10	32	]	]	-RRB-
cord-312386-88uwlmjx	10	33	[	[	-LRB-
cord-312386-88uwlmjx	10	34	5	5	CD
cord-312386-88uwlmjx	10	35	]	]	-RRB-
cord-312386-88uwlmjx	10	36	.	.	.
cord-312386-88uwlmjx	11	1	STATs	stat	NNS
cord-312386-88uwlmjx	11	2	were	be	VBD
cord-312386-88uwlmjx	11	3	first	first	RB
cord-312386-88uwlmjx	11	4	discovered	discover	VBN
cord-312386-88uwlmjx	11	5	through	through	IN
cord-312386-88uwlmjx	11	6	their	-PRON-	PRP$
cord-312386-88uwlmjx	11	7	capacity	capacity	NN
cord-312386-88uwlmjx	11	8	to	to	TO
cord-312386-88uwlmjx	11	9	mediate	mediate	VB
cord-312386-88uwlmjx	11	10	signalling	signal	VBG
cord-312386-88uwlmjx	11	11	from	from	IN
cord-312386-88uwlmjx	11	12	interferon	interferon	NN
cord-312386-88uwlmjx	11	13	(	(	-LRB-
cord-312386-88uwlmjx	11	14	IFN	IFN	NNP
cord-312386-88uwlmjx	11	15	)	)	-RRB-
cord-312386-88uwlmjx	11	16	and	and	CC
cord-312386-88uwlmjx	11	17	interleukin-6	interleukin-6	NNP
cord-312386-88uwlmjx	11	18	(	(	-LRB-
cord-312386-88uwlmjx	11	19	IL-6	IL-6	NNP
cord-312386-88uwlmjx	11	20	)	)	-RRB-
cord-312386-88uwlmjx	11	21	receptors	receptor	NNS
cord-312386-88uwlmjx	11	22	following	follow	VBG
cord-312386-88uwlmjx	11	23	binding	bind	VBG
cord-312386-88uwlmjx	11	24	of	of	IN
cord-312386-88uwlmjx	11	25	cytokines	cytokine	NNS
cord-312386-88uwlmjx	11	26	[	[	-LRB-
cord-312386-88uwlmjx	11	27	3	3	CD
cord-312386-88uwlmjx	11	28	,	,	,
cord-312386-88uwlmjx	11	29	4	4	CD
cord-312386-88uwlmjx	11	30	,	,	,
cord-312386-88uwlmjx	11	31	[	[	-LRB-
cord-312386-88uwlmjx	11	32	6	6	CD
cord-312386-88uwlmjx	11	33	]	]	-RRB-
cord-312386-88uwlmjx	11	34	[	[	-LRB-
cord-312386-88uwlmjx	11	35	7	7	CD
cord-312386-88uwlmjx	11	36	]	]	-RRB-
cord-312386-88uwlmjx	11	37	[	[	-LRB-
cord-312386-88uwlmjx	11	38	8	8	CD
cord-312386-88uwlmjx	11	39	]	]	-RRB-
cord-312386-88uwlmjx	11	40	.	.	.
cord-312386-88uwlmjx	12	1	Each	each	DT
cord-312386-88uwlmjx	12	2	STAT	stat	NN
cord-312386-88uwlmjx	12	3	family	family	NN
cord-312386-88uwlmjx	12	4	protein	protein	NN
cord-312386-88uwlmjx	12	5	responds	respond	VBZ
cord-312386-88uwlmjx	12	6	to	to	IN
cord-312386-88uwlmjx	12	7	a	a	DT
cord-312386-88uwlmjx	12	8	defined	define	VBN
cord-312386-88uwlmjx	12	9	set	set	NN
cord-312386-88uwlmjx	12	10	of	of	IN
cord-312386-88uwlmjx	12	11	cytokines	cytokine	NNS
cord-312386-88uwlmjx	12	12	(	(	-LRB-
cord-312386-88uwlmjx	12	13	Table	table	NN
cord-312386-88uwlmjx	12	14	1	1	CD
cord-312386-88uwlmjx	12	15	)	)	-RRB-
cord-312386-88uwlmjx	12	16	,	,	,
cord-312386-88uwlmjx	12	17	and	and	CC
cord-312386-88uwlmjx	12	18	certain	certain	JJ
cord-312386-88uwlmjx	12	19	cytokines	cytokine	NNS
cord-312386-88uwlmjx	12	20	can	can	MD
cord-312386-88uwlmjx	12	21	activate	activate	VB
cord-312386-88uwlmjx	12	22	more	more	JJR
cord-312386-88uwlmjx	12	23	than	than	IN
cord-312386-88uwlmjx	12	24	one	one	CD
cord-312386-88uwlmjx	12	25	STAT	stat	NN
cord-312386-88uwlmjx	12	26	protein	protein	NN
cord-312386-88uwlmjx	12	27	[	[	-LRB-
cord-312386-88uwlmjx	12	28	9	9	CD
cord-312386-88uwlmjx	12	29	]	]	-RRB-
cord-312386-88uwlmjx	12	30	.	.	.
cord-312386-88uwlmjx	13	1	Cytokine	cytokine	NN
cord-312386-88uwlmjx	13	2	receptors	receptor	NNS
cord-312386-88uwlmjx	13	3	on	on	IN
cord-312386-88uwlmjx	13	4	plasma	plasma	NN
cord-312386-88uwlmjx	13	5	membrane	membrane	NN
cord-312386-88uwlmjx	13	6	do	do	VBP
cord-312386-88uwlmjx	13	7	not	not	RB
cord-312386-88uwlmjx	13	8	usually	usually	RB
cord-312386-88uwlmjx	13	9	possess	possess	VB
cord-312386-88uwlmjx	13	10	intrinsic	intrinsic	JJ
cord-312386-88uwlmjx	13	11	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	13	12	kinase	kinase	NN
cord-312386-88uwlmjx	13	13	activity	activity	NN
cord-312386-88uwlmjx	13	14	and	and	CC
cord-312386-88uwlmjx	13	15	their	-PRON-	PRP$
cord-312386-88uwlmjx	13	16	engagement	engagement	NN
cord-312386-88uwlmjx	13	17	activates	activate	VBZ
cord-312386-88uwlmjx	13	18	receptor	receptor	NN
cord-312386-88uwlmjx	13	19	-	-	HYPH
cord-312386-88uwlmjx	13	20	associated	associate	VBN
cord-312386-88uwlmjx	13	21	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	13	22	kinases	kinase	NNS
cord-312386-88uwlmjx	13	23	,	,	,
cord-312386-88uwlmjx	13	24	prominent	prominent	JJ
cord-312386-88uwlmjx	13	25	of	of	IN
cord-312386-88uwlmjx	13	26	which	which	WDT
cord-312386-88uwlmjx	13	27	are	be	VBP
cord-312386-88uwlmjx	13	28	Janus	Janus	NNP
cord-312386-88uwlmjx	13	29	kinase	kinase	NNS
cord-312386-88uwlmjx	13	30	(	(	-LRB-
cord-312386-88uwlmjx	13	31	JAK	JAK	NNP
cord-312386-88uwlmjx	13	32	)	)	-RRB-
cord-312386-88uwlmjx	13	33	family	family	NN
cord-312386-88uwlmjx	13	34	kinases	kinase	NNS
cord-312386-88uwlmjx	13	35	(	(	-LRB-
cord-312386-88uwlmjx	13	36	JAK1	JAK1	NNP
cord-312386-88uwlmjx	13	37	,	,	,
cord-312386-88uwlmjx	13	38	JAK2	JAK2	NNP
cord-312386-88uwlmjx	13	39	,	,	,
cord-312386-88uwlmjx	13	40	JAK3	JAK3	NNP
cord-312386-88uwlmjx	13	41	,	,	,
cord-312386-88uwlmjx	13	42	and	and	CC
cord-312386-88uwlmjx	13	43	TYK2	TYK2	NNP
cord-312386-88uwlmjx	13	44	)	)	-RRB-
cord-312386-88uwlmjx	13	45	[	[	-LRB-
cord-312386-88uwlmjx	13	46	3	3	CD
cord-312386-88uwlmjx	13	47	,	,	,
cord-312386-88uwlmjx	13	48	4	4	CD
cord-312386-88uwlmjx	13	49	,	,	,
cord-312386-88uwlmjx	13	50	[	[	-LRB-
cord-312386-88uwlmjx	13	51	8	8	CD
cord-312386-88uwlmjx	13	52	]	]	-RRB-
cord-312386-88uwlmjx	13	53	[	[	-LRB-
cord-312386-88uwlmjx	13	54	9	9	CD
cord-312386-88uwlmjx	13	55	]	]	-RRB-
cord-312386-88uwlmjx	13	56	[	[	-LRB-
cord-312386-88uwlmjx	13	57	10	10	CD
cord-312386-88uwlmjx	13	58	]	]	-RRB-
cord-312386-88uwlmjx	13	59	.	.	.
cord-312386-88uwlmjx	14	1	STAT	stat	NN
cord-312386-88uwlmjx	14	2	proteins	protein	NNS
cord-312386-88uwlmjx	14	3	are	be	VBP
cord-312386-88uwlmjx	14	4	activated	activate	VBN
cord-312386-88uwlmjx	14	5	by	by	IN
cord-312386-88uwlmjx	14	6	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	14	7	of	of	IN
cord-312386-88uwlmjx	14	8	specific	specific	JJ
cord-312386-88uwlmjx	14	9	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	14	10	residues	residue	NNS
cord-312386-88uwlmjx	14	11	,	,	,
cord-312386-88uwlmjx	14	12	following	follow	VBG
cord-312386-88uwlmjx	14	13	which	which	WDT
cord-312386-88uwlmjx	14	14	they	-PRON-	PRP
cord-312386-88uwlmjx	14	15	form	form	VBP
cord-312386-88uwlmjx	14	16	stable	stable	JJ
cord-312386-88uwlmjx	14	17	homodimers	homodimer	NNS
cord-312386-88uwlmjx	14	18	or	or	CC
cord-312386-88uwlmjx	14	19	heterodimers	heterodimer	NNS
cord-312386-88uwlmjx	14	20	with	with	IN
cord-312386-88uwlmjx	14	21	other	other	JJ
cord-312386-88uwlmjx	14	22	STAT	stat	NN
cord-312386-88uwlmjx	14	23	proteins	protein	NNS
cord-312386-88uwlmjx	14	24	through	through	IN
cord-312386-88uwlmjx	14	25	reciprocal	reciprocal	JJ
cord-312386-88uwlmjx	14	26	phosphotyrosine	phosphotyrosine	NN
cord-312386-88uwlmjx	14	27	-	-	HYPH
cord-312386-88uwlmjx	14	28	SRC	SRC	NNP
cord-312386-88uwlmjx	14	29	homology	homology	NN
cord-312386-88uwlmjx	14	30	2	2	CD
cord-312386-88uwlmjx	15	1	(	(	-LRB-
cord-312386-88uwlmjx	15	2	SH2	SH2	NNP
cord-312386-88uwlmjx	15	3	)	)	-RRB-
cord-312386-88uwlmjx	15	4	domain	domain	NN
cord-312386-88uwlmjx	15	5	interactions	interaction	NNS
cord-312386-88uwlmjx	15	6	[	[	-LRB-
cord-312386-88uwlmjx	15	7	9	9	CD
cord-312386-88uwlmjx	15	8	]	]	-RRB-
cord-312386-88uwlmjx	15	9	.	.	.
cord-312386-88uwlmjx	16	1	STAT	stat	NN
cord-312386-88uwlmjx	16	2	dimers	dimer	NNS
cord-312386-88uwlmjx	16	3	then	then	RB
cord-312386-88uwlmjx	16	4	translocate	translocate	VBP
cord-312386-88uwlmjx	16	5	to	to	IN
cord-312386-88uwlmjx	16	6	nucleus	nucleus	NN
cord-312386-88uwlmjx	16	7	where	where	WRB
cord-312386-88uwlmjx	16	8	they	-PRON-	PRP
cord-312386-88uwlmjx	16	9	regulate	regulate	VBP
cord-312386-88uwlmjx	16	10	the	the	DT
cord-312386-88uwlmjx	16	11	transcription	transcription	NN
cord-312386-88uwlmjx	16	12	of	of	IN
cord-312386-88uwlmjx	16	13	a	a	DT
cord-312386-88uwlmjx	16	14	set	set	NN
cord-312386-88uwlmjx	16	15	of	of	IN
cord-312386-88uwlmjx	16	16	specific	specific	JJ
cord-312386-88uwlmjx	16	17	genes	gene	NNS
cord-312386-88uwlmjx	16	18	.	.	.
cord-312386-88uwlmjx	17	1	A	a	DT
cord-312386-88uwlmjx	17	2	number	number	NN
cord-312386-88uwlmjx	17	3	of	of	IN
cord-312386-88uwlmjx	17	4	the	the	DT
cord-312386-88uwlmjx	17	5	downstream	downstream	JJ
cord-312386-88uwlmjx	17	6	target	target	NN
cord-312386-88uwlmjx	17	7	genes	gene	NNS
cord-312386-88uwlmjx	17	8	of	of	IN
cord-312386-88uwlmjx	17	9	STATs	stat	NNS
cord-312386-88uwlmjx	17	10	encode	encode	VBP
cord-312386-88uwlmjx	17	11	cytokines	cytokine	NNS
cord-312386-88uwlmjx	17	12	and	and	CC
cord-312386-88uwlmjx	17	13	growth	growth	NN
cord-312386-88uwlmjx	17	14	factors	factor	NNS
cord-312386-88uwlmjx	17	15	,	,	,
cord-312386-88uwlmjx	17	16	which	which	WDT
cord-312386-88uwlmjx	17	17	in	in	IN
cord-312386-88uwlmjx	17	18	turn	turn	NN
cord-312386-88uwlmjx	17	19	mediate	mediate	VBP
cord-312386-88uwlmjx	17	20	autocrine	autocrine	NN
cord-312386-88uwlmjx	17	21	and	and	CC
cord-312386-88uwlmjx	17	22	paracrine	paracrine	JJ
cord-312386-88uwlmjx	17	23	STAT	stat	NN
cord-312386-88uwlmjx	17	24	activation	activation	NN
cord-312386-88uwlmjx	17	25	[	[	-LRB-
cord-312386-88uwlmjx	17	26	9	9	CD
cord-312386-88uwlmjx	17	27	]	]	-RRB-
cord-312386-88uwlmjx	17	28	.	.	.
cord-312386-88uwlmjx	18	1	In	in	IN
cord-312386-88uwlmjx	18	2	addition	addition	NN
cord-312386-88uwlmjx	18	3	to	to	IN
cord-312386-88uwlmjx	18	4	the	the	DT
cord-312386-88uwlmjx	18	5	canonical	canonical	JJ
cord-312386-88uwlmjx	18	6	model	model	NN
cord-312386-88uwlmjx	18	7	of	of	IN
cord-312386-88uwlmjx	18	8	JAK	JAK	NNP
cord-312386-88uwlmjx	18	9	/	/	SYM
cord-312386-88uwlmjx	18	10	STAT	stat	NN
cord-312386-88uwlmjx	18	11	signalling	signal	VBG
cord-312386-88uwlmjx	18	12	,	,	,
cord-312386-88uwlmjx	18	13	STATs	stat	NNS
cord-312386-88uwlmjx	18	14	also	also	RB
cord-312386-88uwlmjx	18	15	form	form	VBP
cord-312386-88uwlmjx	18	16	dimers	dimer	NNS
cord-312386-88uwlmjx	18	17	in	in	IN
cord-312386-88uwlmjx	18	18	the	the	DT
cord-312386-88uwlmjx	18	19	absence	absence	NN
cord-312386-88uwlmjx	18	20	of	of	IN
cord-312386-88uwlmjx	18	21	the	the	DT
cord-312386-88uwlmjx	18	22	activating	activate	VBG
cord-312386-88uwlmjx	18	23	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	18	24	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	18	25	[	[	-LRB-
cord-312386-88uwlmjx	18	26	11	11	CD
cord-312386-88uwlmjx	18	27	]	]	-RRB-
cord-312386-88uwlmjx	18	28	.	.	.
cord-312386-88uwlmjx	19	1	In	in	IN
cord-312386-88uwlmjx	19	2	the	the	DT
cord-312386-88uwlmjx	19	3	noncanonical	noncanonical	JJ
cord-312386-88uwlmjx	19	4	model	model	NN
cord-312386-88uwlmjx	19	5	,	,	,
cord-312386-88uwlmjx	19	6	unphosphorylated	unphosphorylated	NNP
cord-312386-88uwlmjx	19	7	STATs	STATs	NNP
cord-312386-88uwlmjx	19	8	are	be	VBP
cord-312386-88uwlmjx	19	9	consistently	consistently	RB
cord-312386-88uwlmjx	19	10	found	find	VBN
cord-312386-88uwlmjx	19	11	as	as	IN
cord-312386-88uwlmjx	19	12	a	a	DT
cord-312386-88uwlmjx	19	13	result	result	NN
cord-312386-88uwlmjx	19	14	of	of	IN
cord-312386-88uwlmjx	19	15	constant	constant	JJ
cord-312386-88uwlmjx	19	16	nuclear	nuclear	JJ
cord-312386-88uwlmjx	19	17	import	import	NN
cord-312386-88uwlmjx	19	18	and	and	CC
cord-312386-88uwlmjx	19	19	export	export	NN
cord-312386-88uwlmjx	19	20	.	.	.
cord-312386-88uwlmjx	20	1	These	these	DT
cord-312386-88uwlmjx	20	2	unphosphorylated	unphosphorylate	VBN
cord-312386-88uwlmjx	20	3	nuclear	nuclear	JJ
cord-312386-88uwlmjx	20	4	STAT	stat	NN
cord-312386-88uwlmjx	20	5	molecules	molecule	NNS
cord-312386-88uwlmjx	20	6	might	may	MD
cord-312386-88uwlmjx	20	7	also	also	RB
cord-312386-88uwlmjx	20	8	contribute	contribute	VB
cord-312386-88uwlmjx	20	9	to	to	IN
cord-312386-88uwlmjx	20	10	gene	gene	NN
cord-312386-88uwlmjx	20	11	regulation	regulation	NN
cord-312386-88uwlmjx	20	12	[	[	-LRB-
cord-312386-88uwlmjx	20	13	12	12	CD
cord-312386-88uwlmjx	20	14	]	]	-RRB-
cord-312386-88uwlmjx	20	15	.	.	.
cord-312386-88uwlmjx	21	1	Of	of	IN
cord-312386-88uwlmjx	21	2	all	all	PDT
cord-312386-88uwlmjx	21	3	the	the	DT
cord-312386-88uwlmjx	21	4	STAT	stat	NN
cord-312386-88uwlmjx	21	5	family	family	NN
cord-312386-88uwlmjx	21	6	proteins	protein	NNS
cord-312386-88uwlmjx	21	7	,	,	,
cord-312386-88uwlmjx	21	8	STAT3	STAT3	NNP
cord-312386-88uwlmjx	21	9	is	be	VBZ
cord-312386-88uwlmjx	21	10	unique	unique	JJ
cord-312386-88uwlmjx	21	11	as	as	IN
cord-312386-88uwlmjx	21	12	it	-PRON-	PRP
cord-312386-88uwlmjx	21	13	is	be	VBZ
cord-312386-88uwlmjx	21	14	known	know	VBN
cord-312386-88uwlmjx	21	15	to	to	TO
cord-312386-88uwlmjx	21	16	direct	direct	VB
cord-312386-88uwlmjx	21	17	seemingly	seemingly	RB
cord-312386-88uwlmjx	21	18	contradictory	contradictory	JJ
cord-312386-88uwlmjx	21	19	responses	response	NNS
cord-312386-88uwlmjx	21	20	[	[	-LRB-
cord-312386-88uwlmjx	21	21	13	13	CD
cord-312386-88uwlmjx	21	22	]	]	-RRB-
cord-312386-88uwlmjx	21	23	and	and	CC
cord-312386-88uwlmjx	21	24	is	be	VBZ
cord-312386-88uwlmjx	21	25	essential	essential	JJ
cord-312386-88uwlmjx	21	26	for	for	IN
cord-312386-88uwlmjx	21	27	early	early	JJ
cord-312386-88uwlmjx	21	28	embryonic	embryonic	JJ
cord-312386-88uwlmjx	21	29	development	development	NN
cord-312386-88uwlmjx	21	30	in	in	IN
cord-312386-88uwlmjx	21	31	mice	mouse	NNS
cord-312386-88uwlmjx	21	32	[	[	-LRB-
cord-312386-88uwlmjx	21	33	14	14	CD
cord-312386-88uwlmjx	21	34	]	]	-RRB-
cord-312386-88uwlmjx	21	35	.	.	.
cord-312386-88uwlmjx	22	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	22	2	regulates	regulate	VBZ
cord-312386-88uwlmjx	22	3	cell	cell	NN
cord-312386-88uwlmjx	22	4	-	-	HYPH
cord-312386-88uwlmjx	22	5	cycle	cycle	NN
cord-312386-88uwlmjx	22	6	progression	progression	NN
cord-312386-88uwlmjx	22	7	and	and	CC
cord-312386-88uwlmjx	22	8	apoptosis	apoptosis	NN
cord-312386-88uwlmjx	22	9	,	,	,
cord-312386-88uwlmjx	22	10	plays	play	VBZ
cord-312386-88uwlmjx	22	11	a	a	DT
cord-312386-88uwlmjx	22	12	key	key	JJ
cord-312386-88uwlmjx	22	13	role	role	NN
cord-312386-88uwlmjx	22	14	in	in	IN
cord-312386-88uwlmjx	22	15	oncogenesis	oncogenesis	NNP
cord-312386-88uwlmjx	22	16	[	[	-LRB-
cord-312386-88uwlmjx	22	17	15	15	CD
cord-312386-88uwlmjx	22	18	]	]	-RRB-
cord-312386-88uwlmjx	22	19	,	,	,
cord-312386-88uwlmjx	22	20	and	and	CC
cord-312386-88uwlmjx	22	21	is	be	VBZ
cord-312386-88uwlmjx	22	22	aberrantly	aberrantly	RB
cord-312386-88uwlmjx	22	23	expressed	express	VBN
cord-312386-88uwlmjx	22	24	in	in	IN
cord-312386-88uwlmjx	22	25	cancer	cancer	NN
cord-312386-88uwlmjx	22	26	cells	cell	NNS
cord-312386-88uwlmjx	22	27	[	[	-LRB-
cord-312386-88uwlmjx	22	28	16	16	CD
cord-312386-88uwlmjx	22	29	]	]	-RRB-
cord-312386-88uwlmjx	22	30	.	.	.
cord-312386-88uwlmjx	23	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	23	2	function	function	NN
cord-312386-88uwlmjx	23	3	has	have	VBZ
cord-312386-88uwlmjx	23	4	been	be	VBN
cord-312386-88uwlmjx	23	5	extensively	extensively	RB
cord-312386-88uwlmjx	23	6	2	2	CD
cord-312386-88uwlmjx	23	7	Journal	Journal	NNP
cord-312386-88uwlmjx	23	8	of	of	IN
cord-312386-88uwlmjx	23	9	Immunology	Immunology	NNP
cord-312386-88uwlmjx	23	10	Research	Research	NNP
cord-312386-88uwlmjx	23	11	Table	Table	NNP
cord-312386-88uwlmjx	23	12	1	1	CD
cord-312386-88uwlmjx	23	13	:	:	:
cord-312386-88uwlmjx	23	14	Activators	activator	NNS
cord-312386-88uwlmjx	23	15	of	of	IN
cord-312386-88uwlmjx	23	16	STAT	stat	NN
cord-312386-88uwlmjx	23	17	family	family	NN
cord-312386-88uwlmjx	23	18	proteins	protein	NNS
cord-312386-88uwlmjx	23	19	(	(	-LRB-
cord-312386-88uwlmjx	23	20	adapted	adapt	VBN
cord-312386-88uwlmjx	23	21	from	from	IN
cord-312386-88uwlmjx	23	22	Yu	Yu	NNP
cord-312386-88uwlmjx	23	23	et	et	FW
cord-312386-88uwlmjx	23	24	al	al	NNP
cord-312386-88uwlmjx	23	25	.	.	NNP
cord-312386-88uwlmjx	23	26	,	,	,
cord-312386-88uwlmjx	23	27	2009	2009	CD
cord-312386-88uwlmjx	23	28	[	[	-LRB-
cord-312386-88uwlmjx	23	29	9	9	CD
cord-312386-88uwlmjx	23	30	]	]	-RRB-
cord-312386-88uwlmjx	23	31	)	)	-RRB-
cord-312386-88uwlmjx	23	32	.	.	.
cord-312386-88uwlmjx	24	1	Key	key	JJ
cord-312386-88uwlmjx	24	2	activators	activator	NNS
cord-312386-88uwlmjx	24	3	  	  	_SP
cord-312386-88uwlmjx	25	1	STAT1	STAT1	NNP
cord-312386-88uwlmjx	25	2	 	 	_SP
cord-312386-88uwlmjx	26	1	IFN	IFN	NNP
cord-312386-88uwlmjx	26	2	,	,	,
cord-312386-88uwlmjx	26	3	IFN	IFN	NNP
cord-312386-88uwlmjx	26	4	,	,	,
cord-312386-88uwlmjx	26	5	and	and	CC
cord-312386-88uwlmjx	26	6	IFN	IFN	NNP
cord-312386-88uwlmjx	26	7	 	 	_SP
cord-312386-88uwlmjx	26	8	STAT2	STAT2	NNS
cord-312386-88uwlmjx	26	9	 	 	_SP
cord-312386-88uwlmjx	27	1	IFN	IFN	NNP
cord-312386-88uwlmjx	27	2	and	and	CC
cord-312386-88uwlmjx	27	3	IFN	IFN	NNP
cord-312386-88uwlmjx	27	4	 	 	_SP
cord-312386-88uwlmjx	27	5	STAT3	STAT3	NNP
cord-312386-88uwlmjx	27	6	 	 	_SP
cord-312386-88uwlmjx	27	7	IL-6	IL-6	NNP
cord-312386-88uwlmjx	27	8	,	,	,
cord-312386-88uwlmjx	27	9	IL-10	IL-10	NNP
cord-312386-88uwlmjx	27	10	,	,	,
cord-312386-88uwlmjx	27	11	IL-23	IL-23	NNP
cord-312386-88uwlmjx	27	12	,	,	,
cord-312386-88uwlmjx	27	13	IL-21	IL-21	NNP
cord-312386-88uwlmjx	27	14	,	,	,
cord-312386-88uwlmjx	27	15	IL-11	IL-11	NNP
cord-312386-88uwlmjx	27	16	,	,	,
cord-312386-88uwlmjx	27	17	LIF	LIF	NNP
cord-312386-88uwlmjx	27	18	,	,	,
cord-312386-88uwlmjx	27	19	and	and	CC
cord-312386-88uwlmjx	27	20	OSM	OSM	NNP
cord-312386-88uwlmjx	27	21	 	 	_SP
cord-312386-88uwlmjx	28	1	STAT4	STAT4	NNP
cord-312386-88uwlmjx	28	2	 	 	_SP
cord-312386-88uwlmjx	29	1	IL-12	il-12	VB
cord-312386-88uwlmjx	29	2	 	 	_SP
cord-312386-88uwlmjx	29	3	STAT5A	STAT5A	NNP
cord-312386-88uwlmjx	29	4	and	and	CC
cord-312386-88uwlmjx	29	5	 	 	_SP
cord-312386-88uwlmjx	29	6	STAT5B	stat5b	NN
cord-312386-88uwlmjx	29	7	  	  	_SP
cord-312386-88uwlmjx	30	1	IL-2	IL-2	NNP
cord-312386-88uwlmjx	30	2	,	,	,
cord-312386-88uwlmjx	30	3	GM	GM	NNP
cord-312386-88uwlmjx	30	4	-	-	HYPH
cord-312386-88uwlmjx	30	5	CSF	CSF	NNP
cord-312386-88uwlmjx	30	6	,	,	,
cord-312386-88uwlmjx	30	7	IL-15	IL-15	NNP
cord-312386-88uwlmjx	30	8	,	,	,
cord-312386-88uwlmjx	30	9	IL-7	IL-7	NNP
cord-312386-88uwlmjx	30	10	,	,	,
cord-312386-88uwlmjx	30	11	IL-3	IL-3	NNP
cord-312386-88uwlmjx	30	12	,	,	,
cord-312386-88uwlmjx	30	13	IL-5	IL-5	NNP
cord-312386-88uwlmjx	30	14	,	,	,
cord-312386-88uwlmjx	30	15	growth	growth	NN
cord-312386-88uwlmjx	30	16	 	 	_SP
cord-312386-88uwlmjx	30	17	hormones	hormone	NNS
cord-312386-88uwlmjx	30	18	,	,	,
cord-312386-88uwlmjx	30	19	and	and	CC
cord-312386-88uwlmjx	30	20	prolactin	prolactin	NN
cord-312386-88uwlmjx	30	21	 	 	_SP
cord-312386-88uwlmjx	30	22	STAT6	stat6	XX
cord-312386-88uwlmjx	31	1	IL-4	IL-4	NNP
cord-312386-88uwlmjx	31	2	and	and	CC
cord-312386-88uwlmjx	31	3	IL-13	IL-13	NNP
cord-312386-88uwlmjx	31	4	studied	study	VBD
cord-312386-88uwlmjx	31	5	in	in	IN
cord-312386-88uwlmjx	31	6	cell	cell	NN
cord-312386-88uwlmjx	31	7	culture	culture	NN
cord-312386-88uwlmjx	31	8	systems	system	NNS
cord-312386-88uwlmjx	31	9	.	.	.
cord-312386-88uwlmjx	32	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	32	2	is	be	VBZ
cord-312386-88uwlmjx	32	3	known	know	VBN
cord-312386-88uwlmjx	32	4	to	to	TO
cord-312386-88uwlmjx	32	5	regulate	regulate	VB
cord-312386-88uwlmjx	32	6	a	a	DT
cord-312386-88uwlmjx	32	7	number	number	NN
cord-312386-88uwlmjx	32	8	of	of	IN
cord-312386-88uwlmjx	32	9	distinct	distinct	JJ
cord-312386-88uwlmjx	32	10	responses	response	NNS
cord-312386-88uwlmjx	32	11	in	in	IN
cord-312386-88uwlmjx	32	12	different	different	JJ
cord-312386-88uwlmjx	32	13	cells	cell	NNS
cord-312386-88uwlmjx	32	14	,	,	,
cord-312386-88uwlmjx	32	15	including	include	VBG
cord-312386-88uwlmjx	32	16	induction	induction	NN
cord-312386-88uwlmjx	32	17	of	of	IN
cord-312386-88uwlmjx	32	18	an	an	DT
cord-312386-88uwlmjx	32	19	acute	acute	JJ
cord-312386-88uwlmjx	32	20	-	-	HYPH
cord-312386-88uwlmjx	32	21	phase	phase	NN
cord-312386-88uwlmjx	32	22	response	response	NN
cord-312386-88uwlmjx	32	23	in	in	IN
cord-312386-88uwlmjx	32	24	hepatoma	hepatoma	NNP
cord-312386-88uwlmjx	32	25	cells	cell	NNS
cord-312386-88uwlmjx	32	26	,	,	,
cord-312386-88uwlmjx	32	27	stimulation	stimulation	NN
cord-312386-88uwlmjx	32	28	of	of	IN
cord-312386-88uwlmjx	32	29	proliferation	proliferation	NN
cord-312386-88uwlmjx	32	30	in	in	IN
cord-312386-88uwlmjx	32	31	B	b	NN
cord-312386-88uwlmjx	32	32	lymphocytes	lymphocyte	NNS
cord-312386-88uwlmjx	32	33	,	,	,
cord-312386-88uwlmjx	32	34	activation	activation	NN
cord-312386-88uwlmjx	32	35	of	of	IN
cord-312386-88uwlmjx	32	36	terminal	terminal	JJ
cord-312386-88uwlmjx	32	37	differentiation	differentiation	NN
cord-312386-88uwlmjx	32	38	and	and	CC
cord-312386-88uwlmjx	32	39	growth	growth	NN
cord-312386-88uwlmjx	32	40	arrest	arrest	NN
cord-312386-88uwlmjx	32	41	in	in	IN
cord-312386-88uwlmjx	32	42	monocytes	monocyte	NNS
cord-312386-88uwlmjx	32	43	[	[	-LRB-
cord-312386-88uwlmjx	32	44	4	4	CD
cord-312386-88uwlmjx	32	45	]	]	-RRB-
cord-312386-88uwlmjx	32	46	,	,	,
cord-312386-88uwlmjx	32	47	and	and	CC
cord-312386-88uwlmjx	32	48	maintenance	maintenance	NN
cord-312386-88uwlmjx	32	49	of	of	IN
cord-312386-88uwlmjx	32	50	the	the	DT
cord-312386-88uwlmjx	32	51	pluripotency	pluripotency	NN
cord-312386-88uwlmjx	32	52	of	of	IN
cord-312386-88uwlmjx	32	53	embryonic	embryonic	JJ
cord-312386-88uwlmjx	32	54	stem	stem	NN
cord-312386-88uwlmjx	32	55	cells	cell	NNS
cord-312386-88uwlmjx	32	56	[	[	-LRB-
cord-312386-88uwlmjx	32	57	13	13	CD
cord-312386-88uwlmjx	32	58	,	,	,
cord-312386-88uwlmjx	32	59	[	[	-LRB-
cord-312386-88uwlmjx	32	60	17	17	CD
cord-312386-88uwlmjx	32	61	]	]	-RRB-
cord-312386-88uwlmjx	32	62	[	[	-LRB-
cord-312386-88uwlmjx	32	63	18	18	CD
cord-312386-88uwlmjx	32	64	]	]	-RRB-
cord-312386-88uwlmjx	32	65	[	[	-LRB-
cord-312386-88uwlmjx	32	66	19	19	CD
cord-312386-88uwlmjx	32	67	]	]	-RRB-
cord-312386-88uwlmjx	32	68	[	[	-LRB-
cord-312386-88uwlmjx	32	69	20	20	CD
cord-312386-88uwlmjx	32	70	]	]	-RRB-
cord-312386-88uwlmjx	32	71	.	.	.
cord-312386-88uwlmjx	33	1	The	the	DT
cord-312386-88uwlmjx	33	2	seemingly	seemingly	RB
cord-312386-88uwlmjx	33	3	contradictory	contradictory	JJ
cord-312386-88uwlmjx	33	4	responses	response	NNS
cord-312386-88uwlmjx	33	5	of	of	IN
cord-312386-88uwlmjx	33	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	33	7	could	could	MD
cord-312386-88uwlmjx	33	8	be	be	VB
cord-312386-88uwlmjx	33	9	explained	explain	VBN
cord-312386-88uwlmjx	33	10	in	in	IN
cord-312386-88uwlmjx	33	11	part	part	NN
cord-312386-88uwlmjx	33	12	by	by	IN
cord-312386-88uwlmjx	33	13	the	the	DT
cord-312386-88uwlmjx	33	14	activation	activation	NN
cord-312386-88uwlmjx	33	15	of	of	IN
cord-312386-88uwlmjx	33	16	distinct	distinct	JJ
cord-312386-88uwlmjx	33	17	sets	set	NNS
cord-312386-88uwlmjx	33	18	of	of	IN
cord-312386-88uwlmjx	33	19	target	target	NN
cord-312386-88uwlmjx	33	20	gene	gene	NN
cord-312386-88uwlmjx	33	21	by	by	IN
cord-312386-88uwlmjx	33	22	STAT3	STAT3	NNP
cord-312386-88uwlmjx	33	23	in	in	IN
cord-312386-88uwlmjx	33	24	different	different	JJ
cord-312386-88uwlmjx	33	25	cells	cell	NNS
cord-312386-88uwlmjx	33	26	[	[	-LRB-
cord-312386-88uwlmjx	33	27	21	21	CD
cord-312386-88uwlmjx	33	28	]	]	-RRB-
cord-312386-88uwlmjx	33	29	.	.	.
cord-312386-88uwlmjx	34	1	ND	ND	NNP
cord-312386-88uwlmjx	34	2	CCD	CCD	NNP
cord-312386-88uwlmjx	34	3	DBD	DBD	NNP
cord-312386-88uwlmjx	35	1	Linker	Linker	NNP
cord-312386-88uwlmjx	35	2	SH2	SH2	NNP
cord-312386-88uwlmjx	36	1	TAD	TAD	NNP
cord-312386-88uwlmjx	37	1	The	the	DT
cord-312386-88uwlmjx	37	2	structure	structure	NN
cord-312386-88uwlmjx	37	3	of	of	IN
cord-312386-88uwlmjx	37	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	37	5	is	be	VBZ
cord-312386-88uwlmjx	37	6	similar	similar	JJ
cord-312386-88uwlmjx	37	7	to	to	IN
cord-312386-88uwlmjx	37	8	the	the	DT
cord-312386-88uwlmjx	37	9	other	other	JJ
cord-312386-88uwlmjx	37	10	STAT	stat	NN
cord-312386-88uwlmjx	37	11	family	family	NN
cord-312386-88uwlmjx	37	12	members	member	NNS
cord-312386-88uwlmjx	37	13	comprising	comprise	VBG
cord-312386-88uwlmjx	37	14	six	six	CD
cord-312386-88uwlmjx	37	15	structural	structural	JJ
cord-312386-88uwlmjx	37	16	regions	region	NNS
cord-312386-88uwlmjx	37	17	,	,	,
cord-312386-88uwlmjx	37	18	namely	namely	RB
cord-312386-88uwlmjx	37	19	,	,	,
cord-312386-88uwlmjx	37	20	Nterminal	Nterminal	NNP
cord-312386-88uwlmjx	37	21	domain	domain	NN
cord-312386-88uwlmjx	37	22	(	(	-LRB-
cord-312386-88uwlmjx	37	23	ND	ND	NNP
cord-312386-88uwlmjx	37	24	)	)	-RRB-
cord-312386-88uwlmjx	37	25	,	,	,
cord-312386-88uwlmjx	37	26	coiled	coil	VBN
cord-312386-88uwlmjx	37	27	-	-	HYPH
cord-312386-88uwlmjx	37	28	coil	coil	NN
cord-312386-88uwlmjx	37	29	domain	domain	NN
cord-312386-88uwlmjx	37	30	(	(	-LRB-
cord-312386-88uwlmjx	37	31	CCD	CCD	NNP
cord-312386-88uwlmjx	37	32	)	)	-RRB-
cord-312386-88uwlmjx	37	33	,	,	,
cord-312386-88uwlmjx	37	34	DNAbinding	dnabinding	NN
cord-312386-88uwlmjx	37	35	domain	domain	NN
cord-312386-88uwlmjx	37	36	(	(	-LRB-
cord-312386-88uwlmjx	37	37	DBD	DBD	NNP
cord-312386-88uwlmjx	37	38	)	)	-RRB-
cord-312386-88uwlmjx	37	39	,	,	,
cord-312386-88uwlmjx	37	40	linker	linker	NN
cord-312386-88uwlmjx	37	41	domain	domain	NN
cord-312386-88uwlmjx	37	42	,	,	,
cord-312386-88uwlmjx	37	43	SH2	SH2	NNP
cord-312386-88uwlmjx	37	44	domain	domain	NN
cord-312386-88uwlmjx	37	45	,	,	,
cord-312386-88uwlmjx	37	46	and	and	CC
cord-312386-88uwlmjx	37	47	a	a	DT
cord-312386-88uwlmjx	37	48	C	c	NN
cord-312386-88uwlmjx	37	49	-	-	HYPH
cord-312386-88uwlmjx	37	50	terminal	terminal	JJ
cord-312386-88uwlmjx	37	51	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	37	52	activation	activation	NN
cord-312386-88uwlmjx	37	53	domain	domain	NN
cord-312386-88uwlmjx	37	54	(	(	-LRB-
cord-312386-88uwlmjx	37	55	TAD	tad	NN
cord-312386-88uwlmjx	37	56	)	)	-RRB-
cord-312386-88uwlmjx	38	1	(	(	-LRB-
cord-312386-88uwlmjx	38	2	Figure	figure	NN
cord-312386-88uwlmjx	38	3	1	1	CD
cord-312386-88uwlmjx	38	4	)	)	-RRB-
cord-312386-88uwlmjx	38	5	.	.	.
cord-312386-88uwlmjx	39	1	The	the	DT
cord-312386-88uwlmjx	39	2	core	core	NN
cord-312386-88uwlmjx	39	3	fragment	fragment	NN
cord-312386-88uwlmjx	39	4	of	of	IN
cord-312386-88uwlmjx	39	5	STAT3	STAT3	NNP
cord-312386-88uwlmjx	39	6	comprising	comprise	VBG
cord-312386-88uwlmjx	39	7	CCD	CCD	NNP
cord-312386-88uwlmjx	39	8	,	,	,
cord-312386-88uwlmjx	39	9	DBD	DBD	NNP
cord-312386-88uwlmjx	39	10	,	,	,
cord-312386-88uwlmjx	39	11	linker	linker	NN
cord-312386-88uwlmjx	39	12	,	,	,
cord-312386-88uwlmjx	39	13	and	and	CC
cord-312386-88uwlmjx	39	14	SH2	SH2	NNP
cord-312386-88uwlmjx	39	15	domains	domain	NNS
cord-312386-88uwlmjx	39	16	is	be	VBZ
cord-312386-88uwlmjx	39	17	monomeric	monomeric	JJ
cord-312386-88uwlmjx	39	18	and	and	CC
cord-312386-88uwlmjx	39	19	the	the	DT
cord-312386-88uwlmjx	39	20	dimer	dimer	NN
cord-312386-88uwlmjx	39	21	interface	interface	NN
cord-312386-88uwlmjx	39	22	observed	observe	VBN
cord-312386-88uwlmjx	39	23	in	in	IN
cord-312386-88uwlmjx	39	24	the	the	DT
cord-312386-88uwlmjx	39	25	unphosphorylated	unphosphorylated	NNP
cord-312386-88uwlmjx	39	26	STAT1	STAT1	NNP
cord-312386-88uwlmjx	39	27	core	core	NN
cord-312386-88uwlmjx	39	28	fragment	fragment	NN
cord-312386-88uwlmjx	39	29	structure	structure	NN
cord-312386-88uwlmjx	39	30	is	be	VBZ
cord-312386-88uwlmjx	39	31	absent	absent	JJ
cord-312386-88uwlmjx	39	32	in	in	IN
cord-312386-88uwlmjx	39	33	the	the	DT
cord-312386-88uwlmjx	39	34	STAT3	STAT3	NNP
cord-312386-88uwlmjx	39	35	structure	structure	NN
cord-312386-88uwlmjx	39	36	[	[	-LRB-
cord-312386-88uwlmjx	39	37	22	22	CD
cord-312386-88uwlmjx	39	38	]	]	-RRB-
cord-312386-88uwlmjx	39	39	.	.	.
cord-312386-88uwlmjx	40	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	40	2	is	be	VBZ
cord-312386-88uwlmjx	40	3	activated	activate	VBN
cord-312386-88uwlmjx	40	4	by	by	IN
cord-312386-88uwlmjx	40	5	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	40	6	at	at	IN
cord-312386-88uwlmjx	40	7	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	40	8	705	705	CD
cord-312386-88uwlmjx	40	9	in	in	IN
cord-312386-88uwlmjx	40	10	the	the	DT
cord-312386-88uwlmjx	40	11	C	c	NN
cord-312386-88uwlmjx	40	12	-	-	HYPH
cord-312386-88uwlmjx	40	13	terminal	terminal	NN
cord-312386-88uwlmjx	40	14	domain	domain	NN
cord-312386-88uwlmjx	40	15	[	[	-LRB-
cord-312386-88uwlmjx	40	16	2	2	CD
cord-312386-88uwlmjx	40	17	]	]	-RRB-
cord-312386-88uwlmjx	40	18	and	and	CC
cord-312386-88uwlmjx	40	19	more	more	JJR
cord-312386-88uwlmjx	40	20	than	than	IN
cord-312386-88uwlmjx	40	21	40	40	CD
cord-312386-88uwlmjx	40	22	different	different	JJ
cord-312386-88uwlmjx	40	23	polypeptide	polypeptide	NN
cord-312386-88uwlmjx	40	24	ligands	ligand	NNS
cord-312386-88uwlmjx	40	25	are	be	VBP
cord-312386-88uwlmjx	40	26	known	know	VBN
cord-312386-88uwlmjx	40	27	to	to	TO
cord-312386-88uwlmjx	40	28	cause	cause	VB
cord-312386-88uwlmjx	40	29	STAT3	STAT3	NNP
cord-312386-88uwlmjx	40	30	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	40	31	[	[	-LRB-
cord-312386-88uwlmjx	40	32	16	16	CD
cord-312386-88uwlmjx	40	33	]	]	-RRB-
cord-312386-88uwlmjx	40	34	.	.	.
cord-312386-88uwlmjx	41	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	41	2	was	be	VBD
cord-312386-88uwlmjx	41	3	initially	initially	RB
cord-312386-88uwlmjx	41	4	described	describe	VBN
cord-312386-88uwlmjx	41	5	as	as	IN
cord-312386-88uwlmjx	41	6	a	a	DT
cord-312386-88uwlmjx	41	7	DNA	dna	NN
cord-312386-88uwlmjx	41	8	-	-	HYPH
cord-312386-88uwlmjx	41	9	binding	bind	VBG
cord-312386-88uwlmjx	41	10	factor	factor	NN
cord-312386-88uwlmjx	41	11	that	that	WDT
cord-312386-88uwlmjx	41	12	is	be	VBZ
cord-312386-88uwlmjx	41	13	capable	capable	JJ
cord-312386-88uwlmjx	41	14	of	of	IN
cord-312386-88uwlmjx	41	15	selectively	selectively	RB
cord-312386-88uwlmjx	41	16	interacting	interact	VBG
cord-312386-88uwlmjx	41	17	with	with	IN
cord-312386-88uwlmjx	41	18	an	an	DT
cord-312386-88uwlmjx	41	19	enhancer	enhancer	NN
cord-312386-88uwlmjx	41	20	element	element	NN
cord-312386-88uwlmjx	41	21	in	in	IN
cord-312386-88uwlmjx	41	22	the	the	DT
cord-312386-88uwlmjx	41	23	promoter	promoter	NN
cord-312386-88uwlmjx	41	24	region	region	NN
cord-312386-88uwlmjx	41	25	of	of	IN
cord-312386-88uwlmjx	41	26	acute	acute	JJ
cord-312386-88uwlmjx	41	27	-	-	HYPH
cord-312386-88uwlmjx	41	28	phase	phase	NN
cord-312386-88uwlmjx	41	29	genes	gene	NNS
cord-312386-88uwlmjx	41	30	in	in	IN
cord-312386-88uwlmjx	41	31	interleukin-6	interleukin-6	NNP
cord-312386-88uwlmjx	42	1	(	(	-LRB-
cord-312386-88uwlmjx	42	2	IL-6	IL-6	NNP
cord-312386-88uwlmjx	42	3	)	)	-RRB-
cord-312386-88uwlmjx	42	4	stimulated	stimulate	VBN
cord-312386-88uwlmjx	42	5	hepatocytes	hepatocyte	NNS
cord-312386-88uwlmjx	42	6	[	[	-LRB-
cord-312386-88uwlmjx	42	7	7	7	CD
cord-312386-88uwlmjx	42	8	]	]	-RRB-
cord-312386-88uwlmjx	42	9	.	.	.
cord-312386-88uwlmjx	43	1	Subsequently	subsequently	RB
cord-312386-88uwlmjx	43	2	,	,	,
cord-312386-88uwlmjx	43	3	it	-PRON-	PRP
cord-312386-88uwlmjx	43	4	became	become	VBD
cord-312386-88uwlmjx	43	5	evident	evident	JJ
cord-312386-88uwlmjx	43	6	that	that	IN
cord-312386-88uwlmjx	43	7	STAT3	STAT3	NNP
cord-312386-88uwlmjx	43	8	can	can	MD
cord-312386-88uwlmjx	43	9	be	be	VB
cord-312386-88uwlmjx	43	10	activated	activate	VBN
cord-312386-88uwlmjx	43	11	by	by	IN
cord-312386-88uwlmjx	43	12	the	the	DT
cord-312386-88uwlmjx	43	13	entire	entire	JJ
cord-312386-88uwlmjx	43	14	IL-6	IL-6	NNP
cord-312386-88uwlmjx	43	15	family	family	NN
cord-312386-88uwlmjx	43	16	and	and	CC
cord-312386-88uwlmjx	43	17	other	other	JJ
cord-312386-88uwlmjx	43	18	cytokines	cytokine	NNS
cord-312386-88uwlmjx	43	19	including	include	VBG
cord-312386-88uwlmjx	43	20	leukemia	leukemia	NN
cord-312386-88uwlmjx	43	21	inhibitory	inhibitory	JJ
cord-312386-88uwlmjx	43	22	factor	factor	NN
cord-312386-88uwlmjx	43	23	(	(	-LRB-
cord-312386-88uwlmjx	43	24	LIF	LIF	NNP
cord-312386-88uwlmjx	43	25	)	)	-RRB-
cord-312386-88uwlmjx	43	26	,	,	,
cord-312386-88uwlmjx	43	27	cardiotrophin-1	cardiotrophin-1	NNP
cord-312386-88uwlmjx	43	28	,	,	,
cord-312386-88uwlmjx	43	29	ciliary	ciliary	NN
cord-312386-88uwlmjx	43	30	neurotrophic	neurotrophic	NN
cord-312386-88uwlmjx	43	31	factor	factor	NN
cord-312386-88uwlmjx	43	32	(	(	-LRB-
cord-312386-88uwlmjx	43	33	CNTF	CNTF	NNP
cord-312386-88uwlmjx	43	34	)	)	-RRB-
cord-312386-88uwlmjx	43	35	,	,	,
cord-312386-88uwlmjx	43	36	IL-5	IL-5	NNP
cord-312386-88uwlmjx	43	37	,	,	,
cord-312386-88uwlmjx	43	38	IL-9	IL-9	NNP
cord-312386-88uwlmjx	43	39	,	,	,
cord-312386-88uwlmjx	43	40	IL-10	IL-10	NNP
cord-312386-88uwlmjx	43	41	,	,	,
cord-312386-88uwlmjx	43	42	IL-11	IL-11	NNP
cord-312386-88uwlmjx	43	43	,	,	,
cord-312386-88uwlmjx	43	44	IL-12	IL-12	NNP
cord-312386-88uwlmjx	43	45	,	,	,
cord-312386-88uwlmjx	43	46	IL-21	IL-21	NNP
cord-312386-88uwlmjx	43	47	,	,	,
cord-312386-88uwlmjx	43	48	IL-22	IL-22	NNP
cord-312386-88uwlmjx	43	49	,	,	,
cord-312386-88uwlmjx	43	50	IL-27	IL-27	NNP
cord-312386-88uwlmjx	43	51	,	,	,
cord-312386-88uwlmjx	43	52	IFN-	IFN-	NNP
cord-312386-88uwlmjx	43	53	,	,	,
cord-312386-88uwlmjx	43	54	TNF-	TNF-	NNP
cord-312386-88uwlmjx	43	55	,	,	,
cord-312386-88uwlmjx	43	56	LIGHT	LIGHT	NNP
cord-312386-88uwlmjx	43	57	,	,	,
cord-312386-88uwlmjx	43	58	a	a	DT
cord-312386-88uwlmjx	43	59	member	member	NN
cord-312386-88uwlmjx	43	60	of	of	IN
cord-312386-88uwlmjx	43	61	the	the	DT
cord-312386-88uwlmjx	43	62	TNF	TNF	NNP
cord-312386-88uwlmjx	43	63	superfamily	superfamily	NN
cord-312386-88uwlmjx	43	64	,	,	,
cord-312386-88uwlmjx	43	65	monocyte	monocyte	NNP
cord-312386-88uwlmjx	43	66	chemotactic	chemotactic	VBD
cord-312386-88uwlmjx	43	67	protein-1	protein-1	NNP
cord-312386-88uwlmjx	43	68	(	(	-LRB-
cord-312386-88uwlmjx	43	69	MCP-1	MCP-1	NNP
cord-312386-88uwlmjx	43	70	)	)	-RRB-
cord-312386-88uwlmjx	43	71	,	,	,
cord-312386-88uwlmjx	43	72	macrophage	macrophage	NN
cord-312386-88uwlmjx	43	73	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	43	74	protein-1	protein-1	NNP
cord-312386-88uwlmjx	43	75	(	(	-LRB-
cord-312386-88uwlmjx	43	76	MIP-1	MIP-1	NNP
cord-312386-88uwlmjx	43	77	)	)	-RRB-
cord-312386-88uwlmjx	43	78	,	,	,
cord-312386-88uwlmjx	43	79	CCL-5	CCL-5	NNP
cord-312386-88uwlmjx	43	80	/	/	SYM
cord-312386-88uwlmjx	43	81	RANTES	RANTES	NNPS
cord-312386-88uwlmjx	43	82	,	,	,
cord-312386-88uwlmjx	43	83	stem	stem	NN
cord-312386-88uwlmjx	43	84	cell	cell	NN
cord-312386-88uwlmjx	43	85	factor	factor	NN
cord-312386-88uwlmjx	43	86	(	(	-LRB-
cord-312386-88uwlmjx	43	87	SCF	SCF	NNP
cord-312386-88uwlmjx	43	88	)	)	-RRB-
cord-312386-88uwlmjx	43	89	,	,	,
cord-312386-88uwlmjx	43	90	and	and	CC
cord-312386-88uwlmjx	43	91	oncostatin	oncostatin	NNP
cord-312386-88uwlmjx	43	92	M	M	NNP
cord-312386-88uwlmjx	43	93	(	(	-LRB-
cord-312386-88uwlmjx	43	94	OSM	OSM	NNP
cord-312386-88uwlmjx	43	95	)	)	-RRB-
cord-312386-88uwlmjx	44	1	[	[	-LRB-
cord-312386-88uwlmjx	44	2	23	23	CD
cord-312386-88uwlmjx	44	3	]	]	-RRB-
cord-312386-88uwlmjx	45	1	[	[	-LRB-
cord-312386-88uwlmjx	45	2	24	24	CD
cord-312386-88uwlmjx	45	3	]	]	-RRB-
cord-312386-88uwlmjx	45	4	[	[	-LRB-
cord-312386-88uwlmjx	45	5	25	25	CD
cord-312386-88uwlmjx	45	6	]	]	-RRB-
cord-312386-88uwlmjx	45	7	[	[	-LRB-
cord-312386-88uwlmjx	45	8	26	26	CD
cord-312386-88uwlmjx	45	9	]	]	-RRB-
cord-312386-88uwlmjx	45	10	[	[	-LRB-
cord-312386-88uwlmjx	45	11	27	27	CD
cord-312386-88uwlmjx	45	12	]	]	-RRB-
cord-312386-88uwlmjx	45	13	[	[	-LRB-
cord-312386-88uwlmjx	45	14	28	28	CD
cord-312386-88uwlmjx	45	15	]	]	-RRB-
cord-312386-88uwlmjx	45	16	[	[	-LRB-
cord-312386-88uwlmjx	45	17	29	29	CD
cord-312386-88uwlmjx	45	18	]	]	-RRB-
cord-312386-88uwlmjx	46	1	[	[	-LRB-
cord-312386-88uwlmjx	46	2	30	30	CD
cord-312386-88uwlmjx	46	3	]	]	-RRB-
cord-312386-88uwlmjx	46	4	[	[	-LRB-
cord-312386-88uwlmjx	46	5	31	31	CD
cord-312386-88uwlmjx	46	6	]	]	-RRB-
cord-312386-88uwlmjx	47	1	[	[	-LRB-
cord-312386-88uwlmjx	47	2	32	32	CD
cord-312386-88uwlmjx	47	3	]	]	-RRB-
cord-312386-88uwlmjx	47	4	[	[	-LRB-
cord-312386-88uwlmjx	47	5	33	33	CD
cord-312386-88uwlmjx	47	6	]	]	-RRB-
cord-312386-88uwlmjx	47	7	[	[	-LRB-
cord-312386-88uwlmjx	47	8	34	34	CD
cord-312386-88uwlmjx	47	9	]	]	-RRB-
cord-312386-88uwlmjx	48	1	[	[	-LRB-
cord-312386-88uwlmjx	48	2	35	35	CD
cord-312386-88uwlmjx	48	3	]	]	-RRB-
cord-312386-88uwlmjx	48	4	[	[	-LRB-
cord-312386-88uwlmjx	48	5	36	36	CD
cord-312386-88uwlmjx	48	6	]	]	-RRB-
cord-312386-88uwlmjx	49	1	[	[	-LRB-
cord-312386-88uwlmjx	49	2	37	37	CD
cord-312386-88uwlmjx	49	3	]	]	-RRB-
cord-312386-88uwlmjx	49	4	[	[	-LRB-
cord-312386-88uwlmjx	49	5	38	38	CD
cord-312386-88uwlmjx	49	6	]	]	-RRB-
cord-312386-88uwlmjx	49	7	.	.	.
cord-312386-88uwlmjx	50	1	Various	various	JJ
cord-312386-88uwlmjx	50	2	growth	growth	NN
cord-312386-88uwlmjx	50	3	factor	factor	NN
cord-312386-88uwlmjx	50	4	receptors	receptor	NNS
cord-312386-88uwlmjx	50	5	also	also	RB
cord-312386-88uwlmjx	50	6	activate	activate	VBP
cord-312386-88uwlmjx	50	7	STAT3	STAT3	NNP
cord-312386-88uwlmjx	50	8	,	,	,
cord-312386-88uwlmjx	50	9	which	which	WDT
cord-312386-88uwlmjx	50	10	include	include	VBP
cord-312386-88uwlmjx	50	11	epidermal	epidermal	JJ
cord-312386-88uwlmjx	50	12	growth	growth	NN
cord-312386-88uwlmjx	50	13	factor	factor	NN
cord-312386-88uwlmjx	50	14	receptors	receptor	NNS
cord-312386-88uwlmjx	50	15	(	(	-LRB-
cord-312386-88uwlmjx	50	16	EGFRs	egfr	NNS
cord-312386-88uwlmjx	50	17	)	)	-RRB-
cord-312386-88uwlmjx	50	18	,	,	,
cord-312386-88uwlmjx	50	19	hepatocyte	hepatocyte	NN
cord-312386-88uwlmjx	50	20	growth	growth	NN
cord-312386-88uwlmjx	50	21	factor	factor	NN
cord-312386-88uwlmjx	50	22	receptors	receptor	NNS
cord-312386-88uwlmjx	50	23	(	(	-LRB-
cord-312386-88uwlmjx	50	24	HGFRs	hgfr	NNS
cord-312386-88uwlmjx	50	25	)	)	-RRB-
cord-312386-88uwlmjx	50	26	,	,	,
cord-312386-88uwlmjx	50	27	fibroblast	fibroblast	NN
cord-312386-88uwlmjx	50	28	growth	growth	NN
cord-312386-88uwlmjx	50	29	factor	factor	NN
cord-312386-88uwlmjx	50	30	receptors	receptor	NNS
cord-312386-88uwlmjx	50	31	(	(	-LRB-
cord-312386-88uwlmjx	50	32	FGFRs	fgfr	NNS
cord-312386-88uwlmjx	50	33	)	)	-RRB-
cord-312386-88uwlmjx	50	34	,	,	,
cord-312386-88uwlmjx	50	35	platelet	platelet	NN
cord-312386-88uwlmjx	50	36	-	-	HYPH
cord-312386-88uwlmjx	50	37	derived	derive	VBN
cord-312386-88uwlmjx	50	38	growth	growth	NN
cord-312386-88uwlmjx	50	39	factor	factor	NN
cord-312386-88uwlmjx	50	40	receptors	receptor	NNS
cord-312386-88uwlmjx	50	41	(	(	-LRB-
cord-312386-88uwlmjx	50	42	PDGFRs	PDGFRs	NNP
cord-312386-88uwlmjx	50	43	)	)	-RRB-
cord-312386-88uwlmjx	50	44	,	,	,
cord-312386-88uwlmjx	50	45	insulin	insulin	NN
cord-312386-88uwlmjx	50	46	-	-	HYPH
cord-312386-88uwlmjx	50	47	like	like	JJ
cord-312386-88uwlmjx	50	48	growth	growth	NN
cord-312386-88uwlmjx	50	49	factor	factor	NN
cord-312386-88uwlmjx	50	50	receptors	receptor	NNS
cord-312386-88uwlmjx	50	51	(	(	-LRB-
cord-312386-88uwlmjx	50	52	IGFRs	IGFRs	NNP
cord-312386-88uwlmjx	50	53	)	)	-RRB-
cord-312386-88uwlmjx	50	54	,	,	,
cord-312386-88uwlmjx	50	55	and	and	CC
cord-312386-88uwlmjx	50	56	vascular	vascular	JJ
cord-312386-88uwlmjx	50	57	endothelial	endothelial	JJ
cord-312386-88uwlmjx	50	58	growth	growth	NN
cord-312386-88uwlmjx	50	59	factor	factor	NN
cord-312386-88uwlmjx	50	60	receptors	receptor	NNS
cord-312386-88uwlmjx	50	61	(	(	-LRB-
cord-312386-88uwlmjx	50	62	VEGFRs	vegfr	NNS
cord-312386-88uwlmjx	50	63	)	)	-RRB-
cord-312386-88uwlmjx	51	1	[	[	-LRB-
cord-312386-88uwlmjx	51	2	39	39	CD
cord-312386-88uwlmjx	51	3	]	]	-RRB-
cord-312386-88uwlmjx	51	4	.	.	.
cord-312386-88uwlmjx	52	1	In	in	IN
cord-312386-88uwlmjx	52	2	addition	addition	NN
cord-312386-88uwlmjx	52	3	,	,	,
cord-312386-88uwlmjx	52	4	many	many	JJ
cord-312386-88uwlmjx	52	5	carcinogenic	carcinogenic	JJ
cord-312386-88uwlmjx	52	6	agents	agent	NNS
cord-312386-88uwlmjx	52	7	such	such	JJ
cord-312386-88uwlmjx	52	8	as	as	IN
cord-312386-88uwlmjx	52	9	nicotine	nicotine	NN
cord-312386-88uwlmjx	52	10	in	in	IN
cord-312386-88uwlmjx	52	11	cigarette	cigarette	NN
cord-312386-88uwlmjx	52	12	smoke	smoke	NN
cord-312386-88uwlmjx	52	13	,	,	,
cord-312386-88uwlmjx	52	14	diesel	diesel	NN
cord-312386-88uwlmjx	52	15	exhaust	exhaust	NN
cord-312386-88uwlmjx	52	16	particles	particle	NNS
cord-312386-88uwlmjx	52	17	,	,	,
cord-312386-88uwlmjx	52	18	bacterial	bacterial	JJ
cord-312386-88uwlmjx	52	19	lipopolysaccharide	lipopolysaccharide	NN
cord-312386-88uwlmjx	52	20	(	(	-LRB-
cord-312386-88uwlmjx	52	21	LPS	LPS	NNP
cord-312386-88uwlmjx	52	22	)	)	-RRB-
cord-312386-88uwlmjx	52	23	,	,	,
cord-312386-88uwlmjx	52	24	environmental	environmental	JJ
cord-312386-88uwlmjx	52	25	stress	stress	NN
cord-312386-88uwlmjx	52	26	including	include	VBG
cord-312386-88uwlmjx	52	27	ultraviolet	ultraviolet	JJ
cord-312386-88uwlmjx	52	28	light	light	NN
cord-312386-88uwlmjx	52	29	,	,	,
cord-312386-88uwlmjx	52	30	osmotic	osmotic	JJ
cord-312386-88uwlmjx	52	31	shock	shock	NN
cord-312386-88uwlmjx	52	32	,	,	,
cord-312386-88uwlmjx	52	33	heat	heat	NN
cord-312386-88uwlmjx	52	34	shock	shock	NN
cord-312386-88uwlmjx	52	35	,	,	,
cord-312386-88uwlmjx	52	36	and	and	CC
cord-312386-88uwlmjx	52	37	oxidative	oxidative	JJ
cord-312386-88uwlmjx	52	38	stress	stress	NN
cord-312386-88uwlmjx	52	39	,	,	.
cord-312386-88uwlmjx	53	1	Ca	ca	RB
cord-312386-88uwlmjx	53	2	2	2	CD
cord-312386-88uwlmjx	54	1	+	+	CC
cord-312386-88uwlmjx	54	2	/calmodulin	/calmodulin	JJ
cord-312386-88uwlmjx	54	3	-	-	HYPH
cord-312386-88uwlmjx	54	4	dependent	dependent	JJ
cord-312386-88uwlmjx	54	5	protein	protein	NN
cord-312386-88uwlmjx	54	6	kinase	kinase	NN
cord-312386-88uwlmjx	54	7	II	II	NNP
cord-312386-88uwlmjx	54	8	(	(	-LRB-
cord-312386-88uwlmjx	54	9	CaMKII	CaMKII	NNP
cord-312386-88uwlmjx	54	10	)	)	-RRB-
cord-312386-88uwlmjx	54	11	,	,	,
cord-312386-88uwlmjx	54	12	bile	bile	NN
cord-312386-88uwlmjx	54	13	acids	acid	NNS
cord-312386-88uwlmjx	54	14	,	,	,
cord-312386-88uwlmjx	54	15	leptin	leptin	NN
cord-312386-88uwlmjx	54	16	and	and	CC
cord-312386-88uwlmjx	54	17	low	low	JJ
cord-312386-88uwlmjx	54	18	pH	ph	NN
cord-312386-88uwlmjx	54	19	,	,	,
cord-312386-88uwlmjx	54	20	black	black	JJ
cord-312386-88uwlmjx	54	21	soy	soy	NN
cord-312386-88uwlmjx	54	22	peptides	peptide	NNS
cord-312386-88uwlmjx	54	23	,	,	,
cord-312386-88uwlmjx	54	24	diazoxide	diazoxide	NNP
cord-312386-88uwlmjx	54	25	,	,	,
cord-312386-88uwlmjx	54	26	isoliquiritigenin	isoliquiritigenin	NNP
cord-312386-88uwlmjx	54	27	,	,	,
cord-312386-88uwlmjx	54	28	and	and	CC
cord-312386-88uwlmjx	54	29	olanzapine	olanzapine	NN
cord-312386-88uwlmjx	54	30	have	have	VBP
cord-312386-88uwlmjx	54	31	been	be	VBN
cord-312386-88uwlmjx	54	32	found	find	VBN
cord-312386-88uwlmjx	54	33	to	to	TO
cord-312386-88uwlmjx	54	34	activate	activate	VB
cord-312386-88uwlmjx	54	35	STAT3	STAT3	NNP
cord-312386-88uwlmjx	54	36	(	(	-LRB-
cord-312386-88uwlmjx	54	37	reviewed	review	VBN
cord-312386-88uwlmjx	54	38	by	by	IN
cord-312386-88uwlmjx	54	39	Siveen	Siveen	NNP
cord-312386-88uwlmjx	54	40	et	et	NNP
cord-312386-88uwlmjx	54	41	al	al	NNP
cord-312386-88uwlmjx	54	42	.	.	NNP
cord-312386-88uwlmjx	54	43	,	,	,
cord-312386-88uwlmjx	54	44	2014	2014	CD
cord-312386-88uwlmjx	54	45	[	[	-LRB-
cord-312386-88uwlmjx	54	46	16	16	CD
cord-312386-88uwlmjx	54	47	]	]	-RRB-
cord-312386-88uwlmjx	54	48	)	)	-RRB-
cord-312386-88uwlmjx	54	49	.	.	.
cord-312386-88uwlmjx	55	1	Growth	growth	NN
cord-312386-88uwlmjx	55	2	factor	factor	NN
cord-312386-88uwlmjx	55	3	or	or	CC
cord-312386-88uwlmjx	55	4	cytokine	cytokine	JJ
cord-312386-88uwlmjx	55	5	receptor	receptor	NN
cord-312386-88uwlmjx	55	6	-	-	HYPH
cord-312386-88uwlmjx	55	7	ligand	ligand	NN
cord-312386-88uwlmjx	55	8	interaction	interaction	NN
cord-312386-88uwlmjx	55	9	results	result	NNS
cord-312386-88uwlmjx	55	10	in	in	IN
cord-312386-88uwlmjx	55	11	dimerization	dimerization	NN
cord-312386-88uwlmjx	55	12	of	of	IN
cord-312386-88uwlmjx	55	13	gp130	gp130	NNS
cord-312386-88uwlmjx	55	14	,	,	,
cord-312386-88uwlmjx	55	15	a	a	DT
cord-312386-88uwlmjx	55	16	signal	signal	NN
cord-312386-88uwlmjx	55	17	transducer	transducer	NN
cord-312386-88uwlmjx	55	18	protein	protein	NN
cord-312386-88uwlmjx	55	19	in	in	IN
cord-312386-88uwlmjx	55	20	cytoplasm	cytoplasm	NN
cord-312386-88uwlmjx	55	21	[	[	-LRB-
cord-312386-88uwlmjx	55	22	40	40	CD
cord-312386-88uwlmjx	55	23	]	]	-RRB-
cord-312386-88uwlmjx	55	24	.	.	.
cord-312386-88uwlmjx	56	1	This	this	DT
cord-312386-88uwlmjx	56	2	is	be	VBZ
cord-312386-88uwlmjx	56	3	followed	follow	VBN
cord-312386-88uwlmjx	56	4	by	by	IN
cord-312386-88uwlmjx	56	5	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	56	6	of	of	IN
cord-312386-88uwlmjx	56	7	JAK	JAK	NNP
cord-312386-88uwlmjx	56	8	family	family	NN
cord-312386-88uwlmjx	56	9	of	of	IN
cord-312386-88uwlmjx	56	10	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	56	11	kinases	kinase	NNS
cord-312386-88uwlmjx	56	12	especially	especially	RB
cord-312386-88uwlmjx	56	13	JAK1	JAK1	NNP
cord-312386-88uwlmjx	56	14	which	which	WDT
cord-312386-88uwlmjx	56	15	in	in	IN
cord-312386-88uwlmjx	56	16	turn	turn	NN
cord-312386-88uwlmjx	56	17	mediates	mediate	VBZ
cord-312386-88uwlmjx	56	18	STAT3	stat3	NN
cord-312386-88uwlmjx	56	19	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	56	20	[	[	-LRB-
cord-312386-88uwlmjx	56	21	21	21	CD
cord-312386-88uwlmjx	56	22	]	]	-RRB-
cord-312386-88uwlmjx	56	23	.	.	.
cord-312386-88uwlmjx	57	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	57	2	has	have	VBZ
cord-312386-88uwlmjx	57	3	two	two	CD
cord-312386-88uwlmjx	57	4	important	important	JJ
cord-312386-88uwlmjx	57	5	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	57	6	sites	site	NNS
cord-312386-88uwlmjx	57	7	at	at	IN
cord-312386-88uwlmjx	57	8	Tyr705	tyr705	CD
cord-312386-88uwlmjx	57	9	and	and	CC
cord-312386-88uwlmjx	57	10	Ser727	ser727	NN
cord-312386-88uwlmjx	57	11	.	.	.
cord-312386-88uwlmjx	58	1	Ser727	Ser727	NFP
cord-312386-88uwlmjx	58	2	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	58	3	has	have	VBZ
cord-312386-88uwlmjx	58	4	been	be	VBN
cord-312386-88uwlmjx	58	5	considered	consider	VBN
cord-312386-88uwlmjx	58	6	to	to	TO
cord-312386-88uwlmjx	58	7	be	be	VB
cord-312386-88uwlmjx	58	8	a	a	DT
cord-312386-88uwlmjx	58	9	secondary	secondary	JJ
cord-312386-88uwlmjx	58	10	event	event	NN
cord-312386-88uwlmjx	58	11	after	after	IN
cord-312386-88uwlmjx	58	12	Tyr705	tyr705	DT
cord-312386-88uwlmjx	58	13	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	58	14	.	.	.
cord-312386-88uwlmjx	59	1	However	however	RB
cord-312386-88uwlmjx	59	2	,	,	,
cord-312386-88uwlmjx	59	3	recent	recent	JJ
cord-312386-88uwlmjx	59	4	evidence	evidence	NN
cord-312386-88uwlmjx	59	5	suggests	suggest	VBZ
cord-312386-88uwlmjx	59	6	that	that	IN
cord-312386-88uwlmjx	59	7	Ser727	ser727	CD
cord-312386-88uwlmjx	59	8	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	59	9	on	on	IN
cord-312386-88uwlmjx	59	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	59	11	is	be	VBZ
cord-312386-88uwlmjx	59	12	not	not	RB
cord-312386-88uwlmjx	59	13	necessarily	necessarily	RB
cord-312386-88uwlmjx	59	14	a	a	DT
cord-312386-88uwlmjx	59	15	secondary	secondary	JJ
cord-312386-88uwlmjx	59	16	event	event	NN
cord-312386-88uwlmjx	59	17	after	after	IN
cord-312386-88uwlmjx	59	18	Tyr705	tyr705	DT
cord-312386-88uwlmjx	59	19	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	59	20	but	but	CC
cord-312386-88uwlmjx	59	21	has	have	VBZ
cord-312386-88uwlmjx	59	22	a	a	DT
cord-312386-88uwlmjx	59	23	role	role	NN
cord-312386-88uwlmjx	59	24	in	in	IN
cord-312386-88uwlmjx	59	25	the	the	DT
cord-312386-88uwlmjx	59	26	regulation	regulation	NN
cord-312386-88uwlmjx	59	27	of	of	IN
cord-312386-88uwlmjx	59	28	cell	cell	NN
cord-312386-88uwlmjx	59	29	survival	survival	NN
cord-312386-88uwlmjx	59	30	activity	activity	NN
cord-312386-88uwlmjx	59	31	and	and	CC
cord-312386-88uwlmjx	59	32	nuclear	nuclear	JJ
cord-312386-88uwlmjx	59	33	translocation	translocation	NN
cord-312386-88uwlmjx	59	34	of	of	IN
cord-312386-88uwlmjx	59	35	STAT3	STAT3	NNP
cord-312386-88uwlmjx	59	36	in	in	IN
cord-312386-88uwlmjx	59	37	melanocytic	melanocytic	JJ
cord-312386-88uwlmjx	59	38	cells	cell	NNS
cord-312386-88uwlmjx	59	39	[	[	-LRB-
cord-312386-88uwlmjx	59	40	41	41	CD
cord-312386-88uwlmjx	59	41	]	]	-RRB-
cord-312386-88uwlmjx	59	42	.	.	.
cord-312386-88uwlmjx	60	1	Further	further	RB
cord-312386-88uwlmjx	60	2	,	,	,
cord-312386-88uwlmjx	60	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	60	4	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	60	5	at	at	IN
cord-312386-88uwlmjx	60	6	serine	serine	NN
cord-312386-88uwlmjx	60	7	727	727	CD
cord-312386-88uwlmjx	60	8	in	in	IN
cord-312386-88uwlmjx	60	9	the	the	DT
cord-312386-88uwlmjx	60	10	C	C	NNP
cord-312386-88uwlmjx	60	11	-	-	HYPH
cord-312386-88uwlmjx	60	12	terminal	terminal	NN
cord-312386-88uwlmjx	60	13	transactivation	transactivation	NN
cord-312386-88uwlmjx	60	14	domain	domain	NN
cord-312386-88uwlmjx	60	15	promotes	promote	VBZ
cord-312386-88uwlmjx	60	16	maximal	maximal	JJ
cord-312386-88uwlmjx	60	17	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	60	18	activation	activation	NN
cord-312386-88uwlmjx	60	19	of	of	IN
cord-312386-88uwlmjx	60	20	a	a	DT
cord-312386-88uwlmjx	60	21	subset	subset	NN
cord-312386-88uwlmjx	60	22	of	of	IN
cord-312386-88uwlmjx	60	23	target	target	NN
cord-312386-88uwlmjx	60	24	genes	gene	NNS
cord-312386-88uwlmjx	60	25	[	[	-LRB-
cord-312386-88uwlmjx	60	26	42	42	CD
cord-312386-88uwlmjx	60	27	]	]	-RRB-
cord-312386-88uwlmjx	60	28	.	.	.
cord-312386-88uwlmjx	61	1	Furthermore	furthermore	RB
cord-312386-88uwlmjx	61	2	,	,	,
cord-312386-88uwlmjx	61	3	Ser727	ser727	CD
cord-312386-88uwlmjx	61	4	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	61	5	of	of	IN
cord-312386-88uwlmjx	61	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	61	7	appears	appear	VBZ
cord-312386-88uwlmjx	61	8	to	to	TO
cord-312386-88uwlmjx	61	9	be	be	VB
cord-312386-88uwlmjx	61	10	important	important	JJ
cord-312386-88uwlmjx	61	11	in	in	IN
cord-312386-88uwlmjx	61	12	tumorigenicity	tumorigenicity	NN
cord-312386-88uwlmjx	61	13	.	.	.
cord-312386-88uwlmjx	62	1	For	for	IN
cord-312386-88uwlmjx	62	2	example	example	NN
cord-312386-88uwlmjx	62	3	,	,	,
cord-312386-88uwlmjx	62	4	in	in	IN
cord-312386-88uwlmjx	62	5	glioma	glioma	NN
cord-312386-88uwlmjx	62	6	,	,	,
cord-312386-88uwlmjx	62	7	reduced	reduce	VBN
cord-312386-88uwlmjx	62	8	STAT3	STAT3	''
cord-312386-88uwlmjx	63	1	Ser727	Ser727	NFP
cord-312386-88uwlmjx	64	1	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	64	2	enhances	enhance	VBZ
cord-312386-88uwlmjx	64	3	tumorigenicity	tumorigenicity	NN
cord-312386-88uwlmjx	64	4	which	which	WDT
cord-312386-88uwlmjx	64	5	may	may	MD
cord-312386-88uwlmjx	64	6	be	be	VB
cord-312386-88uwlmjx	64	7	regulated	regulate	VBN
cord-312386-88uwlmjx	64	8	in	in	IN
cord-312386-88uwlmjx	64	9	part	part	NN
cord-312386-88uwlmjx	64	10	by	by	IN
cord-312386-88uwlmjx	64	11	CK2-PP2A	CK2-PP2A	NNP
cord-312386-88uwlmjx	64	12	pathway	pathway	NN
cord-312386-88uwlmjx	64	13	[	[	-LRB-
cord-312386-88uwlmjx	64	14	43	43	CD
cord-312386-88uwlmjx	64	15	]	]	-RRB-
cord-312386-88uwlmjx	64	16	.	.	.
cord-312386-88uwlmjx	65	1	The	the	DT
cord-312386-88uwlmjx	65	2	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	65	3	of	of	IN
cord-312386-88uwlmjx	65	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	65	5	promotes	promote	VBZ
cord-312386-88uwlmjx	65	6	homodimerization	homodimerization	NN
cord-312386-88uwlmjx	65	7	,	,	,
cord-312386-88uwlmjx	65	8	wherein	wherein	WRB
cord-312386-88uwlmjx	65	9	the	the	DT
cord-312386-88uwlmjx	65	10	SH2	SH2	NNP
cord-312386-88uwlmjx	65	11	domain	domain	NN
cord-312386-88uwlmjx	65	12	of	of	IN
cord-312386-88uwlmjx	65	13	each	each	DT
cord-312386-88uwlmjx	65	14	STAT3	STAT3	NNP
cord-312386-88uwlmjx	65	15	monomer	monomer	NN
cord-312386-88uwlmjx	65	16	interacts	interact	VBZ
cord-312386-88uwlmjx	65	17	with	with	IN
cord-312386-88uwlmjx	65	18	the	the	DT
cord-312386-88uwlmjx	65	19	Y705	y705	CD
cord-312386-88uwlmjx	65	20	residue	residue	NN
cord-312386-88uwlmjx	65	21	on	on	IN
cord-312386-88uwlmjx	65	22	another	another	DT
cord-312386-88uwlmjx	65	23	monomeric	monomeric	JJ
cord-312386-88uwlmjx	65	24	STAT3	stat3	CD
cord-312386-88uwlmjx	65	25	[	[	-LRB-
cord-312386-88uwlmjx	65	26	2	2	CD
cord-312386-88uwlmjx	65	27	]	]	-RRB-
cord-312386-88uwlmjx	65	28	.	.	.
cord-312386-88uwlmjx	66	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	67	1	homodimers	homodimer	NNS
cord-312386-88uwlmjx	67	2	translocate	translocate	VBP
cord-312386-88uwlmjx	67	3	into	into	IN
cord-312386-88uwlmjx	67	4	the	the	DT
cord-312386-88uwlmjx	67	5	nucleus	nucleus	NN
cord-312386-88uwlmjx	67	6	which	which	WDT
cord-312386-88uwlmjx	67	7	is	be	VBZ
cord-312386-88uwlmjx	67	8	mediated	mediate	VBN
cord-312386-88uwlmjx	67	9	by	by	IN
cord-312386-88uwlmjx	67	10	importin	importin	NNP
cord-312386-88uwlmjx	67	11	5	5	CD
cord-312386-88uwlmjx	68	1	/NPI-1	/NPI-1	NFP
cord-312386-88uwlmjx	68	2	[	[	-LRB-
cord-312386-88uwlmjx	68	3	44	44	CD
cord-312386-88uwlmjx	68	4	]	]	-RRB-
cord-312386-88uwlmjx	68	5	and	and	CC
cord-312386-88uwlmjx	68	6	bind	bind	VB
cord-312386-88uwlmjx	68	7	to	to	IN
cord-312386-88uwlmjx	68	8	specific	specific	JJ
cord-312386-88uwlmjx	68	9	DNA	dna	NN
cord-312386-88uwlmjx	68	10	response	response	NN
cord-312386-88uwlmjx	68	11	elements	element	NNS
cord-312386-88uwlmjx	68	12	such	such	JJ
cord-312386-88uwlmjx	68	13	as	as	IN
cord-312386-88uwlmjx	68	14	the	the	DT
cord-312386-88uwlmjx	68	15	IFN	IFN	NNP
cord-312386-88uwlmjx	68	16	-	-	HYPH
cord-312386-88uwlmjx	68	17	stimulated	stimulate	VBN
cord-312386-88uwlmjx	68	18	response	response	NN
cord-312386-88uwlmjx	68	19	element	element	NN
cord-312386-88uwlmjx	68	20	(	(	-LRB-
cord-312386-88uwlmjx	68	21	ISRE	ISRE	NNP
cord-312386-88uwlmjx	68	22	)	)	-RRB-
cord-312386-88uwlmjx	68	23	in	in	IN
cord-312386-88uwlmjx	68	24	the	the	DT
cord-312386-88uwlmjx	68	25	promoter	promoter	NN
cord-312386-88uwlmjx	68	26	regions	region	NNS
cord-312386-88uwlmjx	68	27	of	of	IN
cord-312386-88uwlmjx	68	28	responsive	responsive	JJ
cord-312386-88uwlmjx	68	29	target	target	NN
cord-312386-88uwlmjx	68	30	genes	gene	NNS
cord-312386-88uwlmjx	68	31	and	and	CC
cord-312386-88uwlmjx	68	32	regulate	regulate	VB
cord-312386-88uwlmjx	68	33	their	-PRON-	PRP$
cord-312386-88uwlmjx	68	34	transcription	transcription	NN
cord-312386-88uwlmjx	68	35	[	[	-LRB-
cord-312386-88uwlmjx	68	36	45	45	CD
cord-312386-88uwlmjx	68	37	]	]	-RRB-
cord-312386-88uwlmjx	68	38	[	[	-LRB-
cord-312386-88uwlmjx	68	39	46	46	CD
cord-312386-88uwlmjx	68	40	]	]	-RRB-
cord-312386-88uwlmjx	68	41	[	[	-LRB-
cord-312386-88uwlmjx	68	42	47	47	CD
cord-312386-88uwlmjx	68	43	]	]	-RRB-
cord-312386-88uwlmjx	69	1	(	(	-LRB-
cord-312386-88uwlmjx	69	2	Figure	figure	NN
cord-312386-88uwlmjx	69	3	2	2	CD
cord-312386-88uwlmjx	69	4	)	)	-RRB-
cord-312386-88uwlmjx	69	5	.	.	.
cord-312386-88uwlmjx	70	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	71	1	dimers	dimer	NNS
cord-312386-88uwlmjx	71	2	recognize	recognize	VBP
cord-312386-88uwlmjx	71	3	an	an	DT
cord-312386-88uwlmjx	71	4	8-to	8-to	CD
cord-312386-88uwlmjx	71	5	10-base	10-base	CD
cord-312386-88uwlmjx	71	6	pair	pair	NN
cord-312386-88uwlmjx	71	7	inverted	inverted	JJ
cord-312386-88uwlmjx	71	8	repeat	repeat	NN
cord-312386-88uwlmjx	71	9	DNA	dna	NN
cord-312386-88uwlmjx	71	10	element	element	NN
cord-312386-88uwlmjx	71	11	with	with	IN
cord-312386-88uwlmjx	71	12	a	a	DT
cord-312386-88uwlmjx	71	13	consensus	consensus	NN
cord-312386-88uwlmjx	71	14	sequence	sequence	NN
cord-312386-88uwlmjx	71	15	of	of	IN
cord-312386-88uwlmjx	71	16	5-TT(N)AA-3	5-tt(n)aa-3	CD
cord-312386-88uwlmjx	71	17	[	[	-LRB-
cord-312386-88uwlmjx	71	18	15	15	CD
cord-312386-88uwlmjx	71	19	]	]	-RRB-
cord-312386-88uwlmjx	71	20	.	.	.
cord-312386-88uwlmjx	72	1	Further	further	RB
cord-312386-88uwlmjx	72	2	,	,	,
cord-312386-88uwlmjx	72	3	nonphosphorylated	nonphosphorylate	VBD
cord-312386-88uwlmjx	72	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	73	1	monomers	monomer	NNS
cord-312386-88uwlmjx	73	2	are	be	VBP
cord-312386-88uwlmjx	73	3	also	also	RB
cord-312386-88uwlmjx	73	4	capable	capable	JJ
cord-312386-88uwlmjx	73	5	of	of	IN
cord-312386-88uwlmjx	73	6	dimerization	dimerization	NN
cord-312386-88uwlmjx	73	7	and	and	CC
cord-312386-88uwlmjx	73	8	induction	induction	NN
cord-312386-88uwlmjx	73	9	of	of	IN
cord-312386-88uwlmjx	73	10	transcription	transcription	NN
cord-312386-88uwlmjx	73	11	through	through	IN
cord-312386-88uwlmjx	73	12	binding	bind	VBG
cord-312386-88uwlmjx	73	13	to	to	IN
cord-312386-88uwlmjx	73	14	NFkappaB	NFkappaB	NNP
cord-312386-88uwlmjx	73	15	[	[	-LRB-
cord-312386-88uwlmjx	73	16	48	48	CD
cord-312386-88uwlmjx	73	17	]	]	-RRB-
cord-312386-88uwlmjx	73	18	.	.	.
cord-312386-88uwlmjx	74	1	Activation	activation	NN
cord-312386-88uwlmjx	74	2	of	of	IN
cord-312386-88uwlmjx	74	3	JAK	JAK	NNP
cord-312386-88uwlmjx	74	4	/	/	SYM
cord-312386-88uwlmjx	74	5	STAT	stat	NN
cord-312386-88uwlmjx	74	6	pathway	pathway	NN
cord-312386-88uwlmjx	74	7	begins	begin	VBZ
cord-312386-88uwlmjx	74	8	with	with	IN
cord-312386-88uwlmjx	74	9	the	the	DT
cord-312386-88uwlmjx	74	10	binding	binding	NN
cord-312386-88uwlmjx	74	11	of	of	IN
cord-312386-88uwlmjx	74	12	extracellular	extracellular	JJ
cord-312386-88uwlmjx	74	13	signalling	signal	VBG
cord-312386-88uwlmjx	74	14	proteins	protein	NNS
cord-312386-88uwlmjx	74	15	(	(	-LRB-
cord-312386-88uwlmjx	74	16	ESPs	esp	NNS
cord-312386-88uwlmjx	74	17	)	)	-RRB-
cord-312386-88uwlmjx	74	18	to	to	IN
cord-312386-88uwlmjx	74	19	specific	specific	JJ
cord-312386-88uwlmjx	74	20	receptors	receptor	NNS
cord-312386-88uwlmjx	74	21	associated	associate	VBN
cord-312386-88uwlmjx	74	22	with	with	IN
cord-312386-88uwlmjx	74	23	JAKs	jak	NNS
cord-312386-88uwlmjx	74	24	.	.	.
cord-312386-88uwlmjx	75	1	Activated	activate	VBN
cord-312386-88uwlmjx	75	2	JAKs	jak	NNS
cord-312386-88uwlmjx	75	3	then	then	RB
cord-312386-88uwlmjx	75	4	activate	activate	VB
cord-312386-88uwlmjx	75	5	STAT	stat	NN
cord-312386-88uwlmjx	75	6	proteins	protein	NNS
cord-312386-88uwlmjx	75	7	by	by	IN
cord-312386-88uwlmjx	75	8	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	75	9	which	which	WDT
cord-312386-88uwlmjx	75	10	otherwise	otherwise	RB
cord-312386-88uwlmjx	75	11	remain	remain	VBP
cord-312386-88uwlmjx	75	12	latent	latent	JJ
cord-312386-88uwlmjx	75	13	in	in	IN
cord-312386-88uwlmjx	75	14	the	the	DT
cord-312386-88uwlmjx	75	15	cytoplasmic	cytoplasmic	JJ
cord-312386-88uwlmjx	75	16	[	[	-LRB-
cord-312386-88uwlmjx	75	17	49	49	CD
cord-312386-88uwlmjx	75	18	,	,	,
cord-312386-88uwlmjx	75	19	50	50	CD
cord-312386-88uwlmjx	75	20	]	]	-RRB-
cord-312386-88uwlmjx	75	21	.	.	.
cord-312386-88uwlmjx	76	1	A	a	DT
cord-312386-88uwlmjx	76	2	range	range	NN
cord-312386-88uwlmjx	76	3	of	of	IN
cord-312386-88uwlmjx	76	4	endogenous	endogenous	JJ
cord-312386-88uwlmjx	76	5	protein	protein	NN
cord-312386-88uwlmjx	76	6	regulators	regulator	NNS
cord-312386-88uwlmjx	76	7	tightly	tightly	RB
cord-312386-88uwlmjx	76	8	control	control	VBP
cord-312386-88uwlmjx	76	9	the	the	DT
cord-312386-88uwlmjx	76	10	receptor	receptor	NN
cord-312386-88uwlmjx	76	11	-	-	HYPH
cord-312386-88uwlmjx	76	12	induced	induce	VBN
cord-312386-88uwlmjx	76	13	STAT3	stat3	CD
cord-312386-88uwlmjx	76	14	activation	activation	NN
cord-312386-88uwlmjx	76	15	[	[	-LRB-
cord-312386-88uwlmjx	76	16	4	4	CD
cord-312386-88uwlmjx	76	17	,	,	,
cord-312386-88uwlmjx	76	18	[	[	-LRB-
cord-312386-88uwlmjx	76	19	51	51	CD
cord-312386-88uwlmjx	76	20	]	]	-RRB-
cord-312386-88uwlmjx	77	1	[	[	-LRB-
cord-312386-88uwlmjx	77	2	52	52	CD
cord-312386-88uwlmjx	77	3	]	]	-RRB-
cord-312386-88uwlmjx	78	1	[	[	-LRB-
cord-312386-88uwlmjx	78	2	53	53	CD
cord-312386-88uwlmjx	78	3	]	]	-RRB-
cord-312386-88uwlmjx	78	4	.	.	.
cord-312386-88uwlmjx	79	1	Several	several	JJ
cord-312386-88uwlmjx	79	2	protein	protein	NN
cord-312386-88uwlmjx	79	3	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	79	4	phosphatases	phosphatase	NNS
cord-312386-88uwlmjx	79	5	(	(	-LRB-
cord-312386-88uwlmjx	79	6	PTPs	ptp	NNS
cord-312386-88uwlmjx	79	7	)	)	-RRB-
cord-312386-88uwlmjx	79	8	including	include	VBG
cord-312386-88uwlmjx	79	9	SHP-2	SHP-2	NNP
cord-312386-88uwlmjx	79	10	,	,	,
cord-312386-88uwlmjx	79	11	PTP1B	ptp1b	CD
cord-312386-88uwlmjx	79	12	,	,	,
cord-312386-88uwlmjx	79	13	PTP	PTP	NNP
cord-312386-88uwlmjx	79	14	C	C	NNP
cord-312386-88uwlmjx	79	15	,	,	,
cord-312386-88uwlmjx	79	16	TC45	TC45	NNP
cord-312386-88uwlmjx	79	17	,	,	,
cord-312386-88uwlmjx	79	18	and	and	CC
cord-312386-88uwlmjx	79	19	SHP-1	SHP-1	NNP
cord-312386-88uwlmjx	79	20	have	have	VBP
cord-312386-88uwlmjx	79	21	been	be	VBN
cord-312386-88uwlmjx	79	22	implicated	implicate	VBN
cord-312386-88uwlmjx	79	23	in	in	IN
cord-312386-88uwlmjx	79	24	the	the	DT
cord-312386-88uwlmjx	79	25	termination	termination	NN
cord-312386-88uwlmjx	79	26	of	of	IN
cord-312386-88uwlmjx	79	27	STAT3	STAT3	NNP
cord-312386-88uwlmjx	79	28	signaling	signal	VBG
cord-312386-88uwlmjx	79	29	.	.	.
cord-312386-88uwlmjx	80	1	Because	because	IN
cord-312386-88uwlmjx	80	2	only	only	RB
cord-312386-88uwlmjx	80	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	80	4	dimers	dimer	NNS
cord-312386-88uwlmjx	80	5	bind	bind	VBP
cord-312386-88uwlmjx	80	6	to	to	IN
cord-312386-88uwlmjx	80	7	DNA	DNA	NNP
cord-312386-88uwlmjx	80	8	,	,	,
cord-312386-88uwlmjx	80	9	the	the	DT
cord-312386-88uwlmjx	80	10	nuclear	nuclear	JJ
cord-312386-88uwlmjx	80	11	PTP	ptp	NN
cord-312386-88uwlmjx	81	1	TC45	TC45	NNP
cord-312386-88uwlmjx	81	2	may	may	MD
cord-312386-88uwlmjx	81	3	be	be	VB
cord-312386-88uwlmjx	81	4	important	important	JJ
cord-312386-88uwlmjx	81	5	in	in	IN
cord-312386-88uwlmjx	81	6	the	the	DT
cord-312386-88uwlmjx	81	7	termination	termination	NN
cord-312386-88uwlmjx	81	8	of	of	IN
cord-312386-88uwlmjx	81	9	STAT3-mediated	STAT3-mediated	NNP
cord-312386-88uwlmjx	81	10	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	81	11	activation	activation	NN
cord-312386-88uwlmjx	81	12	[	[	-LRB-
cord-312386-88uwlmjx	81	13	51	51	CD
cord-312386-88uwlmjx	81	14	,	,	,
cord-312386-88uwlmjx	81	15	53	53	CD
cord-312386-88uwlmjx	81	16	]	]	-RRB-
cord-312386-88uwlmjx	81	17	.	.	.
cord-312386-88uwlmjx	82	1	Protein	protein	NN
cord-312386-88uwlmjx	82	2	inhibitors	inhibitor	NNS
cord-312386-88uwlmjx	82	3	of	of	IN
cord-312386-88uwlmjx	82	4	activated	activate	VBN
cord-312386-88uwlmjx	82	5	STAT	stat	NN
cord-312386-88uwlmjx	82	6	(	(	-LRB-
cord-312386-88uwlmjx	82	7	PIAS	PIAS	NNP
cord-312386-88uwlmjx	82	8	)	)	-RRB-
cord-312386-88uwlmjx	82	9	family	family	NN
cord-312386-88uwlmjx	82	10	members	member	NNS
cord-312386-88uwlmjx	82	11	are	be	VBP
cord-312386-88uwlmjx	82	12	involved	involve	VBN
cord-312386-88uwlmjx	82	13	in	in	IN
cord-312386-88uwlmjx	82	14	blocking	block	VBG
cord-312386-88uwlmjx	82	15	the	the	DT
cord-312386-88uwlmjx	82	16	DNA	dna	NN
cord-312386-88uwlmjx	82	17	-	-	HYPH
cord-312386-88uwlmjx	82	18	binding	bind	VBG
cord-312386-88uwlmjx	82	19	ability	ability	NN
cord-312386-88uwlmjx	82	20	of	of	IN
cord-312386-88uwlmjx	82	21	STAT	stat	NN
cord-312386-88uwlmjx	82	22	proteins	protein	NNS
cord-312386-88uwlmjx	82	23	thereby	thereby	RB
cord-312386-88uwlmjx	82	24	inhibiting	inhibit	VBG
cord-312386-88uwlmjx	82	25	their	-PRON-	PRP$
cord-312386-88uwlmjx	82	26	function	function	NN
cord-312386-88uwlmjx	82	27	as	as	IN
cord-312386-88uwlmjx	82	28	transcription	transcription	NN
cord-312386-88uwlmjx	82	29	factors	factor	NNS
cord-312386-88uwlmjx	82	30	.	.	.
cord-312386-88uwlmjx	83	1	PIAS	PIAS	NNP
cord-312386-88uwlmjx	83	2	family	family	NN
cord-312386-88uwlmjx	83	3	of	of	IN
cord-312386-88uwlmjx	83	4	proteins	protein	NNS
cord-312386-88uwlmjx	83	5	shares	share	NNS
cord-312386-88uwlmjx	83	6	a	a	DT
cord-312386-88uwlmjx	83	7	highly	highly	RB
cord-312386-88uwlmjx	83	8	conserved	conserved	JJ
cord-312386-88uwlmjx	83	9	domain	domain	NN
cord-312386-88uwlmjx	83	10	structure	structure	NN
cord-312386-88uwlmjx	83	11	comprising	comprise	VBG
cord-312386-88uwlmjx	83	12	the	the	DT
cord-312386-88uwlmjx	83	13	N	n	CD
cord-312386-88uwlmjx	83	14	terminus	terminus	NN
cord-312386-88uwlmjx	83	15	SAP	SAP	NNP
cord-312386-88uwlmjx	83	16	domain	domain	NN
cord-312386-88uwlmjx	83	17	that	that	WDT
cord-312386-88uwlmjx	83	18	can	can	MD
cord-312386-88uwlmjx	83	19	bind	bind	VB
cord-312386-88uwlmjx	83	20	to	to	IN
cord-312386-88uwlmjx	83	21	AT	at	NN
cord-312386-88uwlmjx	83	22	-	-	HYPH
cord-312386-88uwlmjx	83	23	rich	rich	JJ
cord-312386-88uwlmjx	83	24	DNA	dna	NN
cord-312386-88uwlmjx	83	25	sequences	sequence	NNS
cord-312386-88uwlmjx	83	26	and	and	CC
cord-312386-88uwlmjx	83	27	a	a	DT
cord-312386-88uwlmjx	83	28	Pro	Pro	NNP
cord-312386-88uwlmjx	83	29	-	-	NNP
cord-312386-88uwlmjx	83	30	Ile	Ile	NNP
cord-312386-88uwlmjx	83	31	-	-	HYPH
cord-312386-88uwlmjx	83	32	Asn	Asn	NNP
cord-312386-88uwlmjx	83	33	-	-	HYPH
cord-312386-88uwlmjx	83	34	Ile	Ile	NNP
cord-312386-88uwlmjx	83	35	-	-	,
cord-312386-88uwlmjx	83	36	The	the	DT
cord-312386-88uwlmjx	83	37	(	(	-LRB-
cord-312386-88uwlmjx	83	38	PINIT	PINIT	NNP
cord-312386-88uwlmjx	83	39	)	)	-RRB-
cord-312386-88uwlmjx	83	40	motif	motif	NN
cord-312386-88uwlmjx	83	41	,	,	,
cord-312386-88uwlmjx	83	42	which	which	WDT
cord-312386-88uwlmjx	83	43	is	be	VBZ
cord-312386-88uwlmjx	83	44	involved	involve	VBN
cord-312386-88uwlmjx	83	45	in	in	IN
cord-312386-88uwlmjx	83	46	the	the	DT
cord-312386-88uwlmjx	83	47	nuclear	nuclear	JJ
cord-312386-88uwlmjx	83	48	retention	retention	NN
cord-312386-88uwlmjx	83	49	of	of	IN
cord-312386-88uwlmjx	83	50	PIAS	PIAS	NNP
cord-312386-88uwlmjx	83	51	proteins	protein	NNS
cord-312386-88uwlmjx	83	52	.	.	.
cord-312386-88uwlmjx	84	1	PIAS3	PIAS3	NNP
cord-312386-88uwlmjx	84	2	has	have	VBZ
cord-312386-88uwlmjx	84	3	been	be	VBN
cord-312386-88uwlmjx	84	4	shown	show	VBN
cord-312386-88uwlmjx	84	5	to	to	TO
cord-312386-88uwlmjx	84	6	specifically	specifically	RB
cord-312386-88uwlmjx	84	7	bind	bind	VB
cord-312386-88uwlmjx	84	8	to	to	IN
cord-312386-88uwlmjx	84	9	STAT3	STAT3	NNP
cord-312386-88uwlmjx	84	10	and	and	CC
cord-312386-88uwlmjx	84	11	block	block	VB
cord-312386-88uwlmjx	84	12	its	-PRON-	PRP$
cord-312386-88uwlmjx	84	13	DNA	dna	NN
cord-312386-88uwlmjx	84	14	-	-	HYPH
cord-312386-88uwlmjx	84	15	binding	bind	VBG
cord-312386-88uwlmjx	84	16	activity	activity	NN
cord-312386-88uwlmjx	84	17	and	and	CC
cord-312386-88uwlmjx	84	18	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	84	19	activation	activation	NN
cord-312386-88uwlmjx	84	20	[	[	-LRB-
cord-312386-88uwlmjx	84	21	2	2	CD
cord-312386-88uwlmjx	84	22	,	,	,
cord-312386-88uwlmjx	84	23	52	52	CD
cord-312386-88uwlmjx	84	24	,	,	,
cord-312386-88uwlmjx	84	25	54	54	CD
cord-312386-88uwlmjx	84	26	]	]	-RRB-
cord-312386-88uwlmjx	84	27	.	.	.
cord-312386-88uwlmjx	85	1	The	the	DT
cord-312386-88uwlmjx	85	2	family	family	NN
cord-312386-88uwlmjx	85	3	of	of	IN
cord-312386-88uwlmjx	85	4	suppressors	suppressor	NNS
cord-312386-88uwlmjx	85	5	of	of	IN
cord-312386-88uwlmjx	85	6	cytokine	cytokine	NN
cord-312386-88uwlmjx	85	7	signalling	signalling	NN
cord-312386-88uwlmjx	85	8	(	(	-LRB-
cord-312386-88uwlmjx	85	9	SOCS	SOCS	NNP
cord-312386-88uwlmjx	85	10	)	)	-RRB-
cord-312386-88uwlmjx	85	11	acts	act	VBZ
cord-312386-88uwlmjx	85	12	as	as	IN
cord-312386-88uwlmjx	85	13	classical	classical	JJ
cord-312386-88uwlmjx	85	14	feedback	feedback	NN
cord-312386-88uwlmjx	85	15	inhibitors	inhibitor	NNS
cord-312386-88uwlmjx	85	16	of	of	IN
cord-312386-88uwlmjx	85	17	the	the	DT
cord-312386-88uwlmjx	85	18	JAK	JAK	NNP
cord-312386-88uwlmjx	85	19	/	/	SYM
cord-312386-88uwlmjx	85	20	STAT	stat	NN
cord-312386-88uwlmjx	85	21	pathway	pathway	NN
cord-312386-88uwlmjx	85	22	.	.	.
cord-312386-88uwlmjx	86	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	86	2	activates	activate	VBZ
cord-312386-88uwlmjx	86	3	the	the	DT
cord-312386-88uwlmjx	86	4	transcription	transcription	NN
cord-312386-88uwlmjx	86	5	of	of	IN
cord-312386-88uwlmjx	86	6	SOCS3	socs3	NN
cord-312386-88uwlmjx	86	7	which	which	WDT
cord-312386-88uwlmjx	86	8	can	can	MD
cord-312386-88uwlmjx	86	9	block	block	VB
cord-312386-88uwlmjx	86	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	86	11	signalling	signal	VBG
cord-312386-88uwlmjx	86	12	either	either	CC
cord-312386-88uwlmjx	86	13	by	by	IN
cord-312386-88uwlmjx	86	14	direct	direct	JJ
cord-312386-88uwlmjx	86	15	binding	binding	NN
cord-312386-88uwlmjx	86	16	and	and	CC
cord-312386-88uwlmjx	86	17	inhibition	inhibition	NN
cord-312386-88uwlmjx	86	18	of	of	IN
cord-312386-88uwlmjx	86	19	JAKs	jak	NNS
cord-312386-88uwlmjx	86	20	,	,	,
cord-312386-88uwlmjx	86	21	by	by	IN
cord-312386-88uwlmjx	86	22	competing	compete	VBG
cord-312386-88uwlmjx	86	23	with	with	IN
cord-312386-88uwlmjx	86	24	STAT3	STAT3	NNP
cord-312386-88uwlmjx	86	25	for	for	IN
cord-312386-88uwlmjx	86	26	pY	py	NN
cord-312386-88uwlmjx	86	27	-	-	HYPH
cord-312386-88uwlmjx	86	28	binding	bind	VBG
cord-312386-88uwlmjx	86	29	sites	site	NNS
cord-312386-88uwlmjx	86	30	on	on	IN
cord-312386-88uwlmjx	86	31	activated	activate	VBN
cord-312386-88uwlmjx	86	32	receptor	receptor	NN
cord-312386-88uwlmjx	86	33	chains	chain	NNS
cord-312386-88uwlmjx	86	34	,	,	,
cord-312386-88uwlmjx	86	35	or	or	CC
cord-312386-88uwlmjx	86	36	by	by	IN
cord-312386-88uwlmjx	86	37	binding	bind	VBG
cord-312386-88uwlmjx	86	38	signalling	signal	VBG
cord-312386-88uwlmjx	86	39	proteins	protein	NNS
cord-312386-88uwlmjx	86	40	and	and	CC
cord-312386-88uwlmjx	86	41	targeting	target	VBG
cord-312386-88uwlmjx	86	42	them	-PRON-	PRP
cord-312386-88uwlmjx	86	43	for	for	IN
cord-312386-88uwlmjx	86	44	proteasomal	proteasomal	JJ
cord-312386-88uwlmjx	86	45	degradation	degradation	NN
cord-312386-88uwlmjx	86	46	[	[	-LRB-
cord-312386-88uwlmjx	86	47	55	55	CD
cord-312386-88uwlmjx	86	48	,	,	,
cord-312386-88uwlmjx	86	49	56	56	CD
cord-312386-88uwlmjx	86	50	]	]	-RRB-
cord-312386-88uwlmjx	87	1	(	(	-LRB-
cord-312386-88uwlmjx	87	2	Figure	figure	NN
cord-312386-88uwlmjx	87	3	2	2	CD
cord-312386-88uwlmjx	87	4	)	)	-RRB-
cord-312386-88uwlmjx	87	5	.	.	.
cord-312386-88uwlmjx	88	1	Cytokine	Cytokine	NNP
cord-312386-88uwlmjx	88	2	Response	Response	NNP
cord-312386-88uwlmjx	88	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	88	4	is	be	VBZ
cord-312386-88uwlmjx	88	5	a	a	DT
cord-312386-88uwlmjx	88	6	signaling	signal	VBG
cord-312386-88uwlmjx	88	7	mediator	mediator	NN
cord-312386-88uwlmjx	88	8	of	of	IN
cord-312386-88uwlmjx	88	9	IL-6	IL-6	NNP
cord-312386-88uwlmjx	88	10	and	and	CC
cord-312386-88uwlmjx	88	11	IL-10	IL-10	NNP
cord-312386-88uwlmjx	88	12	family	family	NN
cord-312386-88uwlmjx	88	13	members	member	NNS
cord-312386-88uwlmjx	88	14	and	and	CC
cord-312386-88uwlmjx	88	15	other	other	JJ
cord-312386-88uwlmjx	88	16	cytokines	cytokine	NNS
cord-312386-88uwlmjx	88	17	such	such	JJ
cord-312386-88uwlmjx	88	18	as	as	IN
cord-312386-88uwlmjx	88	19	leptin	leptin	NN
cord-312386-88uwlmjx	88	20	and	and	CC
cord-312386-88uwlmjx	88	21	G	G	NNP
cord-312386-88uwlmjx	88	22	-	-	HYPH
cord-312386-88uwlmjx	88	23	CSF	CSF	NNP
cord-312386-88uwlmjx	88	24	[	[	-LRB-
cord-312386-88uwlmjx	88	25	13	13	CD
cord-312386-88uwlmjx	88	26	,	,	,
cord-312386-88uwlmjx	88	27	57	57	CD
cord-312386-88uwlmjx	88	28	]	]	-RRB-
cord-312386-88uwlmjx	88	29	.	.	.
cord-312386-88uwlmjx	89	1	N	n	CD
cord-312386-88uwlmjx	89	2	-	-	HYPH
cord-312386-88uwlmjx	89	3	terminal	terminal	NN
cord-312386-88uwlmjx	89	4	domain	domain	NN
cord-312386-88uwlmjx	89	5	of	of	IN
cord-312386-88uwlmjx	89	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	89	7	negatively	negatively	RB
cord-312386-88uwlmjx	89	8	regulates	regulate	VBZ
cord-312386-88uwlmjx	89	9	type	type	NN
cord-312386-88uwlmjx	89	10	1	1	CD
cord-312386-88uwlmjx	89	11	interferon	interferon	NN
cord-312386-88uwlmjx	89	12	(	(	-LRB-
cord-312386-88uwlmjx	89	13	IFN	IFN	NNP
cord-312386-88uwlmjx	89	14	)	)	-RRB-
cord-312386-88uwlmjx	89	15	response	response	NN
cord-312386-88uwlmjx	89	16	in	in	IN
cord-312386-88uwlmjx	89	17	mice	mouse	NNS
cord-312386-88uwlmjx	89	18	,	,	,
cord-312386-88uwlmjx	89	19	which	which	WDT
cord-312386-88uwlmjx	89	20	is	be	VBZ
cord-312386-88uwlmjx	89	21	independent	independent	JJ
cord-312386-88uwlmjx	89	22	of	of	IN
cord-312386-88uwlmjx	89	23	its	-PRON-	PRP$
cord-312386-88uwlmjx	89	24	function	function	NN
cord-312386-88uwlmjx	89	25	as	as	IN
cord-312386-88uwlmjx	89	26	a	a	DT
cord-312386-88uwlmjx	89	27	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	89	28	factor	factor	NN
cord-312386-88uwlmjx	89	29	[	[	-LRB-
cord-312386-88uwlmjx	89	30	58	58	CD
cord-312386-88uwlmjx	89	31	]	]	-RRB-
cord-312386-88uwlmjx	89	32	.	.	.
cord-312386-88uwlmjx	90	1	While	while	IN
cord-312386-88uwlmjx	90	2	STAT1	stat1	NN
cord-312386-88uwlmjx	90	3	and	and	CC
cord-312386-88uwlmjx	90	4	STAT2	STAT2	NNS
cord-312386-88uwlmjx	90	5	mediate	mediate	VBP
cord-312386-88uwlmjx	90	6	antiviral	antiviral	JJ
cord-312386-88uwlmjx	90	7	and	and	CC
cord-312386-88uwlmjx	90	8	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	90	9	effects	effect	NNS
cord-312386-88uwlmjx	90	10	of	of	IN
cord-312386-88uwlmjx	90	11	type	type	NN
cord-312386-88uwlmjx	90	12	I	-PRON-	PRP
cord-312386-88uwlmjx	90	13	IFNs	ifns	NN
cord-312386-88uwlmjx	90	14	,	,	,
cord-312386-88uwlmjx	90	15	STAT3	STAT3	NNP
cord-312386-88uwlmjx	90	16	has	have	VBZ
cord-312386-88uwlmjx	90	17	been	be	VBN
cord-312386-88uwlmjx	90	18	shown	show	VBN
cord-312386-88uwlmjx	90	19	to	to	TO
cord-312386-88uwlmjx	90	20	negatively	negatively	RB
cord-312386-88uwlmjx	90	21	regulate	regulate	VB
cord-312386-88uwlmjx	90	22	the	the	DT
cord-312386-88uwlmjx	90	23	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	90	24	properties	property	NNS
cord-312386-88uwlmjx	90	25	of	of	IN
cord-312386-88uwlmjx	90	26	type	type	NN
cord-312386-88uwlmjx	90	27	I	-PRON-	PRP
cord-312386-88uwlmjx	90	28	IFNs	ifns	VBP
cord-312386-88uwlmjx	90	29	possibly	possibly	RB
cord-312386-88uwlmjx	90	30	through	through	IN
cord-312386-88uwlmjx	90	31	suppression	suppression	NN
cord-312386-88uwlmjx	90	32	of	of	IN
cord-312386-88uwlmjx	90	33	STAT1	stat1	NN
cord-312386-88uwlmjx	90	34	function	function	NN
cord-312386-88uwlmjx	90	35	[	[	-LRB-
cord-312386-88uwlmjx	90	36	59	59	CD
cord-312386-88uwlmjx	90	37	]	]	-RRB-
cord-312386-88uwlmjx	90	38	.	.	.
cord-312386-88uwlmjx	91	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	91	2	activation	activation	NN
cord-312386-88uwlmjx	91	3	results	result	NNS
cord-312386-88uwlmjx	91	4	in	in	IN
cord-312386-88uwlmjx	91	5	either	either	DT
cord-312386-88uwlmjx	91	6	activation	activation	NN
cord-312386-88uwlmjx	91	7	or	or	CC
cord-312386-88uwlmjx	91	8	suppression	suppression	NN
cord-312386-88uwlmjx	91	9	of	of	IN
cord-312386-88uwlmjx	91	10	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	91	11	response	response	NN
cord-312386-88uwlmjx	91	12	depending	depend	VBG
cord-312386-88uwlmjx	91	13	on	on	IN
cord-312386-88uwlmjx	91	14	the	the	DT
cord-312386-88uwlmjx	91	15	physiological	physiological	JJ
cord-312386-88uwlmjx	91	16	status	status	NN
cord-312386-88uwlmjx	91	17	of	of	IN
cord-312386-88uwlmjx	91	18	the	the	DT
cord-312386-88uwlmjx	91	19	cells	cell	NNS
cord-312386-88uwlmjx	91	20	.	.	.
cord-312386-88uwlmjx	92	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	92	2	is	be	VBZ
cord-312386-88uwlmjx	92	3	found	find	VBN
cord-312386-88uwlmjx	92	4	to	to	TO
cord-312386-88uwlmjx	92	5	be	be	VB
cord-312386-88uwlmjx	92	6	constitutively	constitutively	RB
cord-312386-88uwlmjx	92	7	activated	activate	VBN
cord-312386-88uwlmjx	92	8	in	in	IN
cord-312386-88uwlmjx	92	9	cancer	cancer	NN
cord-312386-88uwlmjx	92	10	cells	cell	NNS
cord-312386-88uwlmjx	92	11	and	and	CC
cord-312386-88uwlmjx	92	12	the	the	DT
cord-312386-88uwlmjx	92	13	persistent	persistent	JJ
cord-312386-88uwlmjx	92	14	activation	activation	NN
cord-312386-88uwlmjx	92	15	of	of	IN
cord-312386-88uwlmjx	92	16	STAT3	STAT3	NNP
cord-312386-88uwlmjx	92	17	in	in	IN
cord-312386-88uwlmjx	92	18	cancer	cancer	NN
cord-312386-88uwlmjx	92	19	cells	cell	NNS
cord-312386-88uwlmjx	92	20	mediates	mediate	VBZ
cord-312386-88uwlmjx	92	21	tumour	tumour	NN
cord-312386-88uwlmjx	92	22	-	-	HYPH
cord-312386-88uwlmjx	92	23	promoting	promote	VBG
cord-312386-88uwlmjx	92	24	inflammation	inflammation	NN
cord-312386-88uwlmjx	92	25	[	[	-LRB-
cord-312386-88uwlmjx	92	26	9	9	CD
cord-312386-88uwlmjx	92	27	]	]	-RRB-
cord-312386-88uwlmjx	92	28	.	.	.
cord-312386-88uwlmjx	93	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	93	2	also	also	RB
cord-312386-88uwlmjx	93	3	promotes	promote	VBZ
cord-312386-88uwlmjx	93	4	a	a	DT
cord-312386-88uwlmjx	93	5	potent	potent	JJ
cord-312386-88uwlmjx	93	6	anti	anti	JJ
cord-312386-88uwlmjx	93	7	-	-	JJ
cord-312386-88uwlmjx	93	8	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	93	9	response	response	NN
cord-312386-88uwlmjx	93	10	(	(	-LRB-
cord-312386-88uwlmjx	93	11	AIR	air	NN
cord-312386-88uwlmjx	93	12	)	)	-RRB-
cord-312386-88uwlmjx	93	13	;	;	:
cord-312386-88uwlmjx	93	14	for	for	IN
cord-312386-88uwlmjx	93	15	example	example	NN
cord-312386-88uwlmjx	93	16	,	,	,
cord-312386-88uwlmjx	93	17	Toxoplasma	Toxoplasma	NNP
cord-312386-88uwlmjx	93	18	gondii	gondii	NN
cord-312386-88uwlmjx	93	19	exploits	exploit	VBZ
cord-312386-88uwlmjx	93	20	host	host	NN
cord-312386-88uwlmjx	93	21	STAT3	STAT3	VBG
cord-312386-88uwlmjx	93	22	to	to	TO
cord-312386-88uwlmjx	93	23	prevent	prevent	VB
cord-312386-88uwlmjx	93	24	LPS	LPS	NNP
cord-312386-88uwlmjx	93	25	-	-	HYPH
cord-312386-88uwlmjx	93	26	triggered	trigger	VBN
cord-312386-88uwlmjx	93	27	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	93	28	cytokine	cytokine	NN
cord-312386-88uwlmjx	93	29	production	production	NN
cord-312386-88uwlmjx	93	30	in	in	IN
cord-312386-88uwlmjx	93	31	infected	infected	JJ
cord-312386-88uwlmjx	93	32	mouse	mouse	NN
cord-312386-88uwlmjx	93	33	macrophages	macrophage	NNS
cord-312386-88uwlmjx	93	34	[	[	-LRB-
cord-312386-88uwlmjx	93	35	60	60	CD
cord-312386-88uwlmjx	93	36	]	]	-RRB-
cord-312386-88uwlmjx	93	37	.	.	.
cord-312386-88uwlmjx	94	1	IL-10	IL-10	NNP
cord-312386-88uwlmjx	94	2	regulates	regulate	VBZ
cord-312386-88uwlmjx	94	3	both	both	CC
cord-312386-88uwlmjx	94	4	acute	acute	JJ
cord-312386-88uwlmjx	94	5	and	and	CC
cord-312386-88uwlmjx	94	6	chronic	chronic	JJ
cord-312386-88uwlmjx	94	7	inflammation	inflammation	NN
cord-312386-88uwlmjx	94	8	[	[	-LRB-
cord-312386-88uwlmjx	94	9	61	61	CD
cord-312386-88uwlmjx	94	10	]	]	-RRB-
cord-312386-88uwlmjx	94	11	and	and	CC
cord-312386-88uwlmjx	94	12	STAT3	STAT3	NNP
cord-312386-88uwlmjx	94	13	is	be	VBZ
cord-312386-88uwlmjx	94	14	essential	essential	JJ
cord-312386-88uwlmjx	94	15	for	for	IN
cord-312386-88uwlmjx	94	16	all	all	DT
cord-312386-88uwlmjx	94	17	known	know	VBN
cord-312386-88uwlmjx	94	18	aspects	aspect	NNS
cord-312386-88uwlmjx	94	19	of	of	IN
cord-312386-88uwlmjx	94	20	the	the	DT
cord-312386-88uwlmjx	94	21	IL-10-regulated	IL-10-regulated	NNP
cord-312386-88uwlmjx	94	22	anti	anti	JJ
cord-312386-88uwlmjx	94	23	-	-	JJ
cord-312386-88uwlmjx	94	24	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	94	25	effect	effect	NN
cord-312386-88uwlmjx	94	26	both	both	CC
cord-312386-88uwlmjx	94	27	in	in	IN
cord-312386-88uwlmjx	94	28	vivo	vivo	NN
cord-312386-88uwlmjx	94	29	and	and	CC
cord-312386-88uwlmjx	94	30	in	in	IN
cord-312386-88uwlmjx	94	31	vitro	vitro	FW
cord-312386-88uwlmjx	94	32	[	[	-LRB-
cord-312386-88uwlmjx	94	33	62	62	CD
cord-312386-88uwlmjx	94	34	]	]	-RRB-
cord-312386-88uwlmjx	94	35	[	[	-LRB-
cord-312386-88uwlmjx	94	36	63	63	CD
cord-312386-88uwlmjx	94	37	]	]	-RRB-
cord-312386-88uwlmjx	94	38	[	[	-LRB-
cord-312386-88uwlmjx	94	39	64	64	CD
cord-312386-88uwlmjx	94	40	]	]	-RRB-
cord-312386-88uwlmjx	94	41	.	.	.
cord-312386-88uwlmjx	95	1	While	while	IN
cord-312386-88uwlmjx	95	2	it	-PRON-	PRP
cord-312386-88uwlmjx	95	3	is	be	VBZ
cord-312386-88uwlmjx	95	4	not	not	RB
cord-312386-88uwlmjx	95	5	clear	clear	JJ
cord-312386-88uwlmjx	95	6	how	how	WRB
cord-312386-88uwlmjx	95	7	the	the	DT
cord-312386-88uwlmjx	95	8	pro	pro	JJ
cord-312386-88uwlmjx	95	9	-	-	JJ
cord-312386-88uwlmjx	95	10	and	and	CC
cord-312386-88uwlmjx	95	11	anti	anti	JJ
cord-312386-88uwlmjx	95	12	-	-	JJ
cord-312386-88uwlmjx	95	13	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	95	14	functions	function	NNS
cord-312386-88uwlmjx	95	15	of	of	IN
cord-312386-88uwlmjx	95	16	STAT3	STAT3	NNP
cord-312386-88uwlmjx	95	17	are	be	VBP
cord-312386-88uwlmjx	95	18	regulated	regulate	VBN
cord-312386-88uwlmjx	95	19	,	,	,
cord-312386-88uwlmjx	95	20	possible	possible	JJ
cord-312386-88uwlmjx	95	21	factors	factor	NNS
cord-312386-88uwlmjx	95	22	could	could	MD
cord-312386-88uwlmjx	95	23	be	be	VB
cord-312386-88uwlmjx	95	24	the	the	DT
cord-312386-88uwlmjx	95	25	physiological	physiological	JJ
cord-312386-88uwlmjx	95	26	status	status	NN
cord-312386-88uwlmjx	95	27	of	of	IN
cord-312386-88uwlmjx	95	28	the	the	DT
cord-312386-88uwlmjx	95	29	cells	cell	NNS
cord-312386-88uwlmjx	95	30	and	and	CC
cord-312386-88uwlmjx	95	31	the	the	DT
cord-312386-88uwlmjx	95	32	length	length	NN
cord-312386-88uwlmjx	95	33	of	of	IN
cord-312386-88uwlmjx	95	34	STAT3	stat3	CD
cord-312386-88uwlmjx	95	35	activation	activation	NN
cord-312386-88uwlmjx	95	36	during	during	IN
cord-312386-88uwlmjx	95	37	a	a	DT
cord-312386-88uwlmjx	95	38	response	response	NN
cord-312386-88uwlmjx	95	39	.	.	.
cord-312386-88uwlmjx	95	40	 	 	_SP
cord-312386-88uwlmjx	96	1	Several	several	JJ
cord-312386-88uwlmjx	96	2	studies	study	NNS
cord-312386-88uwlmjx	96	3	described	describe	VBD
cord-312386-88uwlmjx	96	4	the	the	DT
cord-312386-88uwlmjx	96	5	involvement	involvement	NN
cord-312386-88uwlmjx	96	6	of	of	IN
cord-312386-88uwlmjx	96	7	STAT3	STAT3	NNP
cord-312386-88uwlmjx	96	8	in	in	IN
cord-312386-88uwlmjx	96	9	the	the	DT
cord-312386-88uwlmjx	96	10	replication	replication	NN
cord-312386-88uwlmjx	96	11	and	and	CC
cord-312386-88uwlmjx	96	12	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	96	13	of	of	IN
cord-312386-88uwlmjx	96	14	viruses	virus	NNS
cord-312386-88uwlmjx	96	15	in	in	IN
cord-312386-88uwlmjx	96	16	humans	human	NNS
cord-312386-88uwlmjx	96	17	and	and	CC
cord-312386-88uwlmjx	96	18	animals	animal	NNS
cord-312386-88uwlmjx	96	19	.	.	.
cord-312386-88uwlmjx	97	1	Notably	notably	RB
cord-312386-88uwlmjx	97	2	,	,	,
cord-312386-88uwlmjx	97	3	both	both	CC
cord-312386-88uwlmjx	97	4	pro	pro	JJ
cord-312386-88uwlmjx	97	5	-	-	JJ
cord-312386-88uwlmjx	97	6	and	and	CC
cord-312386-88uwlmjx	97	7	antiviral	antiviral	JJ
cord-312386-88uwlmjx	97	8	functions	function	NNS
cord-312386-88uwlmjx	97	9	of	of	IN
cord-312386-88uwlmjx	97	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	97	11	have	have	VBP
cord-312386-88uwlmjx	97	12	been	be	VBN
cord-312386-88uwlmjx	97	13	documented	document	VBN
cord-312386-88uwlmjx	97	14	and	and	CC
cord-312386-88uwlmjx	97	15	its	-PRON-	PRP$
cord-312386-88uwlmjx	97	16	precise	precise	JJ
cord-312386-88uwlmjx	97	17	role	role	NN
cord-312386-88uwlmjx	97	18	in	in	IN
cord-312386-88uwlmjx	97	19	the	the	DT
cord-312386-88uwlmjx	97	20	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	97	21	of	of	IN
cord-312386-88uwlmjx	97	22	viral	viral	JJ
cord-312386-88uwlmjx	97	23	infections	infection	NNS
cord-312386-88uwlmjx	97	24	is	be	VBZ
cord-312386-88uwlmjx	97	25	not	not	RB
cord-312386-88uwlmjx	97	26	yet	yet	RB
cord-312386-88uwlmjx	97	27	fully	fully	RB
cord-312386-88uwlmjx	97	28	established	establish	VBN
cord-312386-88uwlmjx	97	29	.	.	.
cord-312386-88uwlmjx	98	1	A	a	DT
cord-312386-88uwlmjx	98	2	number	number	NN
cord-312386-88uwlmjx	98	3	of	of	IN
cord-312386-88uwlmjx	98	4	DNA	DNA	NNP
cord-312386-88uwlmjx	98	5	and	and	CC
cord-312386-88uwlmjx	98	6	RNA	RNA	NNP
cord-312386-88uwlmjx	98	7	viruses	virus	NNS
cord-312386-88uwlmjx	98	8	are	be	VBP
cord-312386-88uwlmjx	98	9	known	know	VBN
cord-312386-88uwlmjx	98	10	to	to	TO
cord-312386-88uwlmjx	98	11	regulate	regulate	VB
cord-312386-88uwlmjx	98	12	STAT3	STAT3	NNP
cord-312386-88uwlmjx	98	13	,	,	,
cord-312386-88uwlmjx	98	14	which	which	WDT
cord-312386-88uwlmjx	98	15	is	be	VBZ
cord-312386-88uwlmjx	98	16	summarized	summarize	VBN
cord-312386-88uwlmjx	98	17	in	in	IN
cord-312386-88uwlmjx	98	18	Table	Table	NNP
cord-312386-88uwlmjx	98	19	2	2	CD
cord-312386-88uwlmjx	98	20	.	.	.
cord-312386-88uwlmjx	99	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	99	2	is	be	VBZ
cord-312386-88uwlmjx	99	3	either	either	CC
cord-312386-88uwlmjx	99	4	positively	positively	RB
cord-312386-88uwlmjx	99	5	or	or	CC
cord-312386-88uwlmjx	99	6	negatively	negatively	RB
cord-312386-88uwlmjx	99	7	regulated	regulate	VBN
cord-312386-88uwlmjx	99	8	in	in	IN
cord-312386-88uwlmjx	99	9	a	a	DT
cord-312386-88uwlmjx	99	10	range	range	NN
cord-312386-88uwlmjx	99	11	of	of	IN
cord-312386-88uwlmjx	99	12	viral	viral	JJ
cord-312386-88uwlmjx	99	13	infections	infection	NNS
cord-312386-88uwlmjx	99	14	depending	depend	VBG
cord-312386-88uwlmjx	99	15	on	on	IN
cord-312386-88uwlmjx	99	16	the	the	DT
cord-312386-88uwlmjx	99	17	type	type	NN
cord-312386-88uwlmjx	99	18	of	of	IN
cord-312386-88uwlmjx	99	19	virus	virus	NN
cord-312386-88uwlmjx	99	20	[	[	-LRB-
cord-312386-88uwlmjx	99	21	73	73	CD
cord-312386-88uwlmjx	99	22	]	]	-RRB-
cord-312386-88uwlmjx	99	23	,	,	,
cord-312386-88uwlmjx	99	24	and	and	CC
cord-312386-88uwlmjx	99	25	Varicellazoster	Varicellazoster	NNP
cord-312386-88uwlmjx	99	26	virus	virus	NN
cord-312386-88uwlmjx	99	27	(	(	-LRB-
cord-312386-88uwlmjx	99	28	VZV	VZV	NNP
cord-312386-88uwlmjx	99	29	)	)	-RRB-
cord-312386-88uwlmjx	100	1	[	[	-LRB-
cord-312386-88uwlmjx	100	2	74	74	CD
cord-312386-88uwlmjx	100	3	]	]	-RRB-
cord-312386-88uwlmjx	100	4	promote	promote	VBP
cord-312386-88uwlmjx	100	5	STAT3	STAT3	NNP
cord-312386-88uwlmjx	100	6	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	100	7	in	in	IN
cord-312386-88uwlmjx	100	8	infected	infected	JJ
cord-312386-88uwlmjx	100	9	cells	cell	NNS
cord-312386-88uwlmjx	100	10	.	.	.
cord-312386-88uwlmjx	101	1	In	in	IN
cord-312386-88uwlmjx	101	2	contrast	contrast	NN
cord-312386-88uwlmjx	101	3	,	,	,
cord-312386-88uwlmjx	101	4	influenza	influenza	NN
cord-312386-88uwlmjx	101	5	A	a	DT
cord-312386-88uwlmjx	101	6	virus	virus	NN
cord-312386-88uwlmjx	101	7	(	(	-LRB-
cord-312386-88uwlmjx	101	8	IAV	IAV	NNP
cord-312386-88uwlmjx	101	9	)	)	-RRB-
cord-312386-88uwlmjx	101	10	nonstructural	nonstructural	JJ
cord-312386-88uwlmjx	101	11	protein	protein	NN
cord-312386-88uwlmjx	101	12	1	1	CD
cord-312386-88uwlmjx	101	13	(	(	-LRB-
cord-312386-88uwlmjx	101	14	NS-1	NS-1	NNP
cord-312386-88uwlmjx	101	15	)	)	-RRB-
cord-312386-88uwlmjx	101	16	[	[	-LRB-
cord-312386-88uwlmjx	101	17	75	75	CD
cord-312386-88uwlmjx	101	18	]	]	-RRB-
cord-312386-88uwlmjx	101	19	and	and	CC
cord-312386-88uwlmjx	101	20	human	human	JJ
cord-312386-88uwlmjx	101	21	metapneumovirus	metapneumovirus	NN
cord-312386-88uwlmjx	101	22	[	[	-LRB-
cord-312386-88uwlmjx	101	23	76	76	CD
cord-312386-88uwlmjx	101	24	]	]	-RRB-
cord-312386-88uwlmjx	101	25	impede	impede	VBP
cord-312386-88uwlmjx	101	26	STAT3	stat3	DT
cord-312386-88uwlmjx	101	27	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	101	28	in	in	IN
cord-312386-88uwlmjx	101	29	infected	infected	JJ
cord-312386-88uwlmjx	101	30	cells	cell	NNS
cord-312386-88uwlmjx	101	31	.	.	.
cord-312386-88uwlmjx	102	1	However	however	RB
cord-312386-88uwlmjx	102	2	,	,	,
cord-312386-88uwlmjx	102	3	human	human	JJ
cord-312386-88uwlmjx	102	4	cytomegalovirus	cytomegalovirus	NN
cord-312386-88uwlmjx	102	5	(	(	-LRB-
cord-312386-88uwlmjx	102	6	HCMV	HCMV	NNP
cord-312386-88uwlmjx	102	7	)	)	-RRB-
cord-312386-88uwlmjx	102	8	infection	infection	NN
cord-312386-88uwlmjx	102	9	inhibits	inhibit	VBZ
cord-312386-88uwlmjx	102	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	102	11	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	102	12	but	but	CC
cord-312386-88uwlmjx	102	13	rapidly	rapidly	RB
cord-312386-88uwlmjx	102	14	promotes	promote	VBZ
cord-312386-88uwlmjx	102	15	nuclear	nuclear	JJ
cord-312386-88uwlmjx	102	16	localization	localization	NN
cord-312386-88uwlmjx	102	17	of	of	IN
cord-312386-88uwlmjx	102	18	unphosphorylated	unphosphorylated	NNP
cord-312386-88uwlmjx	102	19	STAT3	STAT3	NNP
cord-312386-88uwlmjx	102	20	to	to	IN
cord-312386-88uwlmjx	102	21	the	the	DT
cord-312386-88uwlmjx	102	22	nucleus	nucleus	NN
cord-312386-88uwlmjx	102	23	and	and	CC
cord-312386-88uwlmjx	102	24	disrupts	disrupt	VBZ
cord-312386-88uwlmjx	102	25	IL-6-induced	il-6-induced	JJ
cord-312386-88uwlmjx	102	26	gene	gene	NN
cord-312386-88uwlmjx	102	27	expression	expression	NN
cord-312386-88uwlmjx	102	28	[	[	-LRB-
cord-312386-88uwlmjx	102	29	77	77	CD
cord-312386-88uwlmjx	102	30	]	]	-RRB-
cord-312386-88uwlmjx	102	31	.	.	.
cord-312386-88uwlmjx	103	1	Severe	severe	JJ
cord-312386-88uwlmjx	103	2	acute	acute	JJ
cord-312386-88uwlmjx	103	3	respiratory	respiratory	JJ
cord-312386-88uwlmjx	103	4	syndrome	syndrome	NN
cord-312386-88uwlmjx	103	5	coronavirus	coronavirus	NN
cord-312386-88uwlmjx	103	6	(	(	-LRB-
cord-312386-88uwlmjx	103	7	SARS	SARS	NNP
cord-312386-88uwlmjx	103	8	-	-	HYPH
cord-312386-88uwlmjx	103	9	CoV	CoV	NNP
cord-312386-88uwlmjx	103	10	)	)	-RRB-
cord-312386-88uwlmjx	103	11	infection	infection	NN
cord-312386-88uwlmjx	103	12	of	of	IN
cord-312386-88uwlmjx	103	13	Vero	Vero	NNP
cord-312386-88uwlmjx	103	14	E6	E6	NNP
cord-312386-88uwlmjx	103	15	cells	cell	NNS
cord-312386-88uwlmjx	103	16	results	result	NNS
cord-312386-88uwlmjx	103	17	in	in	IN
cord-312386-88uwlmjx	103	18	STAT3	stat3	CD
cord-312386-88uwlmjx	103	19	dephosphorylation	dephosphorylation	NN
cord-312386-88uwlmjx	103	20	at	at	IN
cord-312386-88uwlmjx	103	21	Tyr705	tyr705	ADD
cord-312386-88uwlmjx	103	22	[	[	-LRB-
cord-312386-88uwlmjx	103	23	78	78	CD
cord-312386-88uwlmjx	103	24	]	]	-RRB-
cord-312386-88uwlmjx	103	25	.	.	.
cord-312386-88uwlmjx	104	1	In	in	IN
cord-312386-88uwlmjx	104	2	addition	addition	NN
cord-312386-88uwlmjx	104	3	HCV	HCV	NNP
cord-312386-88uwlmjx	104	4	promotes	promote	VBZ
cord-312386-88uwlmjx	104	5	STAT3	STAT3	VBG
cord-312386-88uwlmjx	104	6	ubiquitination	ubiquitination	NN
cord-312386-88uwlmjx	104	7	and	and	CC
cord-312386-88uwlmjx	104	8	degradation	degradation	NN
cord-312386-88uwlmjx	104	9	via	via	IN
cord-312386-88uwlmjx	105	1	the	the	DT
cord-312386-88uwlmjx	105	2	proteasome	proteasome	NN
cord-312386-88uwlmjx	105	3	[	[	-LRB-
cord-312386-88uwlmjx	105	4	79	79	CD
cord-312386-88uwlmjx	105	5	]	]	-RRB-
cord-312386-88uwlmjx	105	6	.	.	.
cord-312386-88uwlmjx	106	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	106	2	plays	play	VBZ
cord-312386-88uwlmjx	106	3	an	an	DT
cord-312386-88uwlmjx	106	4	important	important	JJ
cord-312386-88uwlmjx	106	5	role	role	NN
cord-312386-88uwlmjx	106	6	in	in	IN
cord-312386-88uwlmjx	106	7	adaptive	adaptive	JJ
cord-312386-88uwlmjx	106	8	immune	immune	JJ
cord-312386-88uwlmjx	106	9	response	response	NN
cord-312386-88uwlmjx	106	10	,	,	,
cord-312386-88uwlmjx	106	11	in	in	IN
cord-312386-88uwlmjx	106	12	particular	particular	JJ
cord-312386-88uwlmjx	106	13	in	in	IN
cord-312386-88uwlmjx	106	14	the	the	DT
cord-312386-88uwlmjx	106	15	regulation	regulation	NN
cord-312386-88uwlmjx	106	16	of	of	IN
cord-312386-88uwlmjx	106	17	T	T	NNP
cord-312386-88uwlmjx	106	18	lymphocyte	lymphocyte	NN
cord-312386-88uwlmjx	106	19	function	function	NN
cord-312386-88uwlmjx	106	20	.	.	.
cord-312386-88uwlmjx	107	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	107	2	mediates	mediate	VBZ
cord-312386-88uwlmjx	107	3	IL-6-dependent	il-6-dependent	IN
cord-312386-88uwlmjx	107	4	T	t	NN
cord-312386-88uwlmjx	107	5	cell	cell	NN
cord-312386-88uwlmjx	107	6	proliferation	proliferation	NN
cord-312386-88uwlmjx	107	7	by	by	IN
cord-312386-88uwlmjx	107	8	preventing	prevent	VBG
cord-312386-88uwlmjx	107	9	apoptosis	apoptosis	NN
cord-312386-88uwlmjx	107	10	[	[	-LRB-
cord-312386-88uwlmjx	107	11	80	80	CD
cord-312386-88uwlmjx	107	12	]	]	-RRB-
cord-312386-88uwlmjx	107	13	.	.	.
cord-312386-88uwlmjx	108	1	Further	further	RB
cord-312386-88uwlmjx	108	2	,	,	,
cord-312386-88uwlmjx	108	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	108	4	regulates	regulate	VBZ
cord-312386-88uwlmjx	108	5	proliferation	proliferation	NN
cord-312386-88uwlmjx	108	6	,	,	,
cord-312386-88uwlmjx	108	7	survival	survival	NN
cord-312386-88uwlmjx	108	8	,	,	,
cord-312386-88uwlmjx	108	9	and	and	CC
cord-312386-88uwlmjx	108	10	differentiation	differentiation	NN
cord-312386-88uwlmjx	108	11	of	of	IN
cord-312386-88uwlmjx	108	12	CD4	CD4	NNP
cord-312386-88uwlmjx	108	13	+	+	CC
cord-312386-88uwlmjx	108	14	[	[	-LRB-
cord-312386-88uwlmjx	108	15	81	81	CD
cord-312386-88uwlmjx	108	16	]	]	-RRB-
cord-312386-88uwlmjx	108	17	and	and	CC
cord-312386-88uwlmjx	108	18	CD8	CD8	NNP
cord-312386-88uwlmjx	108	19	+	+	CC
cord-312386-88uwlmjx	108	20	T	T	NNP
cord-312386-88uwlmjx	108	21	cells	cell	NNS
cord-312386-88uwlmjx	108	22	[	[	-LRB-
cord-312386-88uwlmjx	108	23	82	82	CD
cord-312386-88uwlmjx	108	24	]	]	-RRB-
cord-312386-88uwlmjx	108	25	.	.	.
cord-312386-88uwlmjx	109	1	Furthermore	furthermore	RB
cord-312386-88uwlmjx	109	2	,	,	,
cord-312386-88uwlmjx	109	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	109	4	is	be	VBZ
cord-312386-88uwlmjx	109	5	essential	essential	JJ
cord-312386-88uwlmjx	109	6	in	in	IN
cord-312386-88uwlmjx	109	7	upregulating	upregulate	VBG
cord-312386-88uwlmjx	109	8	CD8	CD8	NNP
cord-312386-88uwlmjx	109	9	+	+	CC
cord-312386-88uwlmjx	109	10	T	T	NNP
cord-312386-88uwlmjx	109	11	cell	cell	NN
cord-312386-88uwlmjx	109	12	-	-	HYPH
cord-312386-88uwlmjx	109	13	mediated	mediate	VBN
cord-312386-88uwlmjx	109	14	responses	response	NNS
cord-312386-88uwlmjx	109	15	to	to	IN
cord-312386-88uwlmjx	109	16	viruses	virus	NNS
cord-312386-88uwlmjx	109	17	.	.	.
cord-312386-88uwlmjx	110	1	For	for	IN
cord-312386-88uwlmjx	110	2	example	example	NN
cord-312386-88uwlmjx	110	3	,	,	,
cord-312386-88uwlmjx	110	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	110	5	plays	play	VBZ
cord-312386-88uwlmjx	110	6	an	an	DT
cord-312386-88uwlmjx	110	7	important	important	JJ
cord-312386-88uwlmjx	110	8	role	role	NN
cord-312386-88uwlmjx	110	9	in	in	IN
cord-312386-88uwlmjx	110	10	the	the	DT
cord-312386-88uwlmjx	110	11	activation	activation	NN
cord-312386-88uwlmjx	110	12	of	of	IN
cord-312386-88uwlmjx	110	13	CD8	CD8	NNP
cord-312386-88uwlmjx	110	14	+	+	CC
cord-312386-88uwlmjx	110	15	T	T	NNP
cord-312386-88uwlmjx	110	16	cells	cell	NNS
cord-312386-88uwlmjx	110	17	effective	effective	JJ
cord-312386-88uwlmjx	110	18	response	response	NN
cord-312386-88uwlmjx	110	19	during	during	IN
cord-312386-88uwlmjx	110	20	herpes	herpes	NNP
cord-312386-88uwlmjx	110	21	simplex	simplex	NNP
cord-312386-88uwlmjx	110	22	virus	virus	NN
cord-312386-88uwlmjx	110	23	(	(	-LRB-
cord-312386-88uwlmjx	110	24	HSV-1	hsv-1	NN
cord-312386-88uwlmjx	110	25	)	)	-RRB-
cord-312386-88uwlmjx	110	26	infection	infection	NN
cord-312386-88uwlmjx	110	27	[	[	-LRB-
cord-312386-88uwlmjx	110	28	82	82	CD
cord-312386-88uwlmjx	110	29	]	]	-RRB-
cord-312386-88uwlmjx	110	30	.	.	.
cord-312386-88uwlmjx	111	1	It	-PRON-	PRP
cord-312386-88uwlmjx	111	2	is	be	VBZ
cord-312386-88uwlmjx	111	3	evident	evident	JJ
cord-312386-88uwlmjx	111	4	that	that	IN
cord-312386-88uwlmjx	111	5	viruses	virus	NNS
cord-312386-88uwlmjx	111	6	either	either	CC
cord-312386-88uwlmjx	111	7	promote	promote	VBP
cord-312386-88uwlmjx	111	8	or	or	CC
cord-312386-88uwlmjx	111	9	disrupt	disrupt	VB
cord-312386-88uwlmjx	111	10	STAT3mediated	STAT3mediated	NNP
cord-312386-88uwlmjx	111	11	gene	gene	NN
cord-312386-88uwlmjx	111	12	transcription	transcription	NN
cord-312386-88uwlmjx	111	13	and	and	CC
cord-312386-88uwlmjx	111	14	host	host	NN
cord-312386-88uwlmjx	111	15	immune	immune	JJ
cord-312386-88uwlmjx	111	16	responses	response	NNS
cord-312386-88uwlmjx	111	17	against	against	IN
cord-312386-88uwlmjx	111	18	viruses	virus	NNS
cord-312386-88uwlmjx	111	19	.	.	.
cord-312386-88uwlmjx	112	1	Further	further	RB
cord-312386-88uwlmjx	112	2	,	,	,
cord-312386-88uwlmjx	112	3	activation	activation	NN
cord-312386-88uwlmjx	112	4	or	or	CC
cord-312386-88uwlmjx	112	5	inhibition	inhibition	NN
cord-312386-88uwlmjx	112	6	of	of	IN
cord-312386-88uwlmjx	112	7	STAT3mediated	STAT3mediated	NNP
cord-312386-88uwlmjx	112	8	signalling	signalling	NN
cord-312386-88uwlmjx	112	9	appears	appear	VBZ
cord-312386-88uwlmjx	112	10	to	to	TO
cord-312386-88uwlmjx	112	11	be	be	VB
cord-312386-88uwlmjx	112	12	dependent	dependent	JJ
cord-312386-88uwlmjx	112	13	on	on	IN
cord-312386-88uwlmjx	112	14	virus	virus	NN
cord-312386-88uwlmjx	112	15	and	and	CC
cord-312386-88uwlmjx	112	16	host	host	NN
cord-312386-88uwlmjx	112	17	cell	cell	NN
cord-312386-88uwlmjx	112	18	type	type	NN
cord-312386-88uwlmjx	112	19	involved	involve	VBN
cord-312386-88uwlmjx	112	20	.	.	.
cord-312386-88uwlmjx	113	1	Inhibition	inhibition	NN
cord-312386-88uwlmjx	113	2	of	of	IN
cord-312386-88uwlmjx	113	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	113	4	activation	activation	NN
cord-312386-88uwlmjx	113	5	could	could	MD
cord-312386-88uwlmjx	113	6	be	be	VB
cord-312386-88uwlmjx	113	7	a	a	DT
cord-312386-88uwlmjx	113	8	strategy	strategy	NN
cord-312386-88uwlmjx	113	9	of	of	IN
cord-312386-88uwlmjx	113	10	viruses	virus	NNS
cord-312386-88uwlmjx	113	11	to	to	TO
cord-312386-88uwlmjx	113	12	subvert	subvert	VB
cord-312386-88uwlmjx	113	13	host	host	NN
cord-312386-88uwlmjx	113	14	immune	immune	JJ
cord-312386-88uwlmjx	113	15	responses	response	NNS
cord-312386-88uwlmjx	113	16	.	.	.
cord-312386-88uwlmjx	114	1	On	on	IN
cord-312386-88uwlmjx	114	2	the	the	DT
cord-312386-88uwlmjx	114	3	other	other	JJ
cord-312386-88uwlmjx	114	4	hand	hand	NN
cord-312386-88uwlmjx	114	5	STAT3-mediated	STAT3-mediated	NNP
cord-312386-88uwlmjx	114	6	gene	gene	NN
cord-312386-88uwlmjx	114	7	transcription	transcription	NN
cord-312386-88uwlmjx	114	8	of	of	IN
cord-312386-88uwlmjx	114	9	proviral	proviral	JJ
cord-312386-88uwlmjx	114	10	factors	factor	NNS
cord-312386-88uwlmjx	114	11	could	could	MD
cord-312386-88uwlmjx	114	12	be	be	VB
cord-312386-88uwlmjx	114	13	essential	essential	JJ
cord-312386-88uwlmjx	114	14	for	for	IN
cord-312386-88uwlmjx	114	15	certain	certain	JJ
cord-312386-88uwlmjx	114	16	other	other	JJ
cord-312386-88uwlmjx	114	17	viruses	virus	NNS
cord-312386-88uwlmjx	114	18	.	.	.
cord-312386-88uwlmjx	115	1	It	-PRON-	PRP
cord-312386-88uwlmjx	115	2	is	be	VBZ
cord-312386-88uwlmjx	115	3	possible	possible	JJ
cord-312386-88uwlmjx	115	4	that	that	IN
cord-312386-88uwlmjx	115	5	the	the	DT
cord-312386-88uwlmjx	115	6	timing	timing	NN
cord-312386-88uwlmjx	115	7	of	of	IN
cord-312386-88uwlmjx	115	8	STAT3	stat3	CD
cord-312386-88uwlmjx	115	9	regulation	regulation	NN
cord-312386-88uwlmjx	115	10	during	during	IN
cord-312386-88uwlmjx	115	11	virus	virus	NN
cord-312386-88uwlmjx	115	12	infection	infection	NN
cord-312386-88uwlmjx	115	13	may	may	MD
cord-312386-88uwlmjx	115	14	be	be	VB
cord-312386-88uwlmjx	115	15	critical	critical	JJ
cord-312386-88uwlmjx	115	16	and	and	CC
cord-312386-88uwlmjx	115	17	hence	hence	RB
cord-312386-88uwlmjx	115	18	require	require	VBP
cord-312386-88uwlmjx	115	19	further	further	RB
cord-312386-88uwlmjx	115	20	in	in	IN
cord-312386-88uwlmjx	115	21	depth	depth	NN
cord-312386-88uwlmjx	115	22	studies	study	NNS
cord-312386-88uwlmjx	115	23	to	to	TO
cord-312386-88uwlmjx	115	24	profile	profile	VB
cord-312386-88uwlmjx	115	25	STAT3	STAT3	NNP
cord-312386-88uwlmjx	115	26	regulation	regulation	NN
cord-312386-88uwlmjx	115	27	during	during	IN
cord-312386-88uwlmjx	115	28	different	different	JJ
cord-312386-88uwlmjx	115	29	stages	stage	NNS
cord-312386-88uwlmjx	115	30	of	of	IN
cord-312386-88uwlmjx	115	31	viral	viral	JJ
cord-312386-88uwlmjx	115	32	infection	infection	NN
cord-312386-88uwlmjx	115	33	.	.	.
cord-312386-88uwlmjx	116	1	The	the	DT
cord-312386-88uwlmjx	116	2	role	role	NN
cord-312386-88uwlmjx	116	3	of	of	IN
cord-312386-88uwlmjx	116	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	116	5	in	in	IN
cord-312386-88uwlmjx	116	6	virus	virus	NN
cord-312386-88uwlmjx	116	7	replication	replication	NN
cord-312386-88uwlmjx	116	8	appears	appear	VBZ
cord-312386-88uwlmjx	116	9	to	to	TO
cord-312386-88uwlmjx	116	10	be	be	VB
cord-312386-88uwlmjx	116	11	complex	complex	JJ
cord-312386-88uwlmjx	116	12	,	,	,
cord-312386-88uwlmjx	116	13	as	as	IN
cord-312386-88uwlmjx	116	14	it	-PRON-	PRP
cord-312386-88uwlmjx	116	15	appears	appear	VBZ
cord-312386-88uwlmjx	116	16	to	to	TO
cord-312386-88uwlmjx	116	17	function	function	VB
cord-312386-88uwlmjx	116	18	as	as	IN
cord-312386-88uwlmjx	116	19	a	a	DT
cord-312386-88uwlmjx	116	20	proviral	proviral	JJ
cord-312386-88uwlmjx	116	21	factor	factor	NN
cord-312386-88uwlmjx	116	22	in	in	IN
cord-312386-88uwlmjx	116	23	some	some	DT
cord-312386-88uwlmjx	116	24	viral	viral	JJ
cord-312386-88uwlmjx	116	25	infections	infection	NNS
cord-312386-88uwlmjx	116	26	and	and	CC
cord-312386-88uwlmjx	116	27	antiviral	antiviral	JJ
cord-312386-88uwlmjx	116	28	factor	factor	NN
cord-312386-88uwlmjx	116	29	in	in	IN
cord-312386-88uwlmjx	116	30	others	other	NNS
cord-312386-88uwlmjx	116	31	.	.	.
cord-312386-88uwlmjx	117	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	117	2	cooperatively	cooperatively	RB
cord-312386-88uwlmjx	117	3	interacts	interact	VBZ
cord-312386-88uwlmjx	117	4	with	with	IN
cord-312386-88uwlmjx	117	5	hepatocyte	hepatocyte	NN
cord-312386-88uwlmjx	117	6	nuclear	nuclear	JJ
cord-312386-88uwlmjx	117	7	factor	factor	NN
cord-312386-88uwlmjx	117	8	3	3	CD
cord-312386-88uwlmjx	117	9	(	(	-LRB-
cord-312386-88uwlmjx	117	10	HNF-3	HNF-3	NNP
cord-312386-88uwlmjx	117	11	)	)	-RRB-
cord-312386-88uwlmjx	117	12	and	and	CC
cord-312386-88uwlmjx	117	13	activates	activate	VBZ
cord-312386-88uwlmjx	117	14	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	117	15	B	B	NNP
cord-312386-88uwlmjx	117	16	virus	virus	NN
cord-312386-88uwlmjx	117	17	(	(	-LRB-
cord-312386-88uwlmjx	117	18	HBV	HBV	NNP
cord-312386-88uwlmjx	117	19	)	)	-RRB-
cord-312386-88uwlmjx	117	20	gene	gene	NN
cord-312386-88uwlmjx	117	21	expression	expression	NN
cord-312386-88uwlmjx	117	22	[	[	-LRB-
cord-312386-88uwlmjx	117	23	83	83	CD
cord-312386-88uwlmjx	117	24	]	]	-RRB-
cord-312386-88uwlmjx	117	25	.	.	.
cord-312386-88uwlmjx	118	1	There	there	EX
cord-312386-88uwlmjx	118	2	is	be	VBZ
cord-312386-88uwlmjx	118	3	a	a	DT
cord-312386-88uwlmjx	118	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	118	5	binding	binding	NN
cord-312386-88uwlmjx	118	6	site	site	NN
cord-312386-88uwlmjx	118	7	within	within	IN
cord-312386-88uwlmjx	118	8	the	the	DT
cord-312386-88uwlmjx	118	9	core	core	NN
cord-312386-88uwlmjx	118	10	domain	domain	NN
cord-312386-88uwlmjx	118	11	of	of	IN
cord-312386-88uwlmjx	118	12	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	118	13	B	B	NNP
cord-312386-88uwlmjx	118	14	virus	virus	NN
cord-312386-88uwlmjx	118	15	(	(	-LRB-
cord-312386-88uwlmjx	118	16	HBV	HBV	NNP
cord-312386-88uwlmjx	118	17	)	)	-RRB-
cord-312386-88uwlmjx	118	18	enhancer	enhancer	NN
cord-312386-88uwlmjx	118	19	1	1	CD
cord-312386-88uwlmjx	118	20	.	.	.
cord-312386-88uwlmjx	119	1	IL-6	IL-6	NNP
cord-312386-88uwlmjx	119	2	and	and	CC
cord-312386-88uwlmjx	119	3	epidermal	epidermal	JJ
cord-312386-88uwlmjx	119	4	growth	growth	NN
cord-312386-88uwlmjx	119	5	factor	factor	NN
cord-312386-88uwlmjx	119	6	stimulates	stimulate	VBZ
cord-312386-88uwlmjx	119	7	the	the	DT
cord-312386-88uwlmjx	119	8	interaction	interaction	NN
cord-312386-88uwlmjx	119	9	of	of	IN
cord-312386-88uwlmjx	119	10	HBV	HBV	NNP
cord-312386-88uwlmjx	119	11	enhancer	enhancer	NN
cord-312386-88uwlmjx	119	12	1	1	CD
cord-312386-88uwlmjx	119	13	DNA	dna	NN
cord-312386-88uwlmjx	119	14	-	-	HYPH
cord-312386-88uwlmjx	119	15	STAT3	stat3	NN
cord-312386-88uwlmjx	119	16	protein	protein	NN
cord-312386-88uwlmjx	119	17	resulting	result	VBG
cord-312386-88uwlmjx	119	18	in	in	IN
cord-312386-88uwlmjx	119	19	overall	overall	JJ
cord-312386-88uwlmjx	119	20	stimulation	stimulation	NN
cord-312386-88uwlmjx	119	21	of	of	IN
cord-312386-88uwlmjx	119	22	HBV	HBV	NNP
cord-312386-88uwlmjx	119	23	enhancer	enhancer	NN
cord-312386-88uwlmjx	119	24	1	1	CD
cord-312386-88uwlmjx	119	25	function	function	NN
cord-312386-88uwlmjx	119	26	and	and	CC
cord-312386-88uwlmjx	119	27	viral	viral	JJ
cord-312386-88uwlmjx	119	28	gene	gene	NN
cord-312386-88uwlmjx	119	29	expression	expression	NN
cord-312386-88uwlmjx	119	30	[	[	-LRB-
cord-312386-88uwlmjx	119	31	83	83	CD
cord-312386-88uwlmjx	119	32	]	]	-RRB-
cord-312386-88uwlmjx	119	33	.	.	.
cord-312386-88uwlmjx	120	1	HCV	HCV	NNP
cord-312386-88uwlmjx	120	2	constitutively	constitutively	RB
cord-312386-88uwlmjx	120	3	activates	activate	VBZ
cord-312386-88uwlmjx	120	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	120	5	in	in	IN
cord-312386-88uwlmjx	120	6	liver	liver	NN
cord-312386-88uwlmjx	120	7	cells	cell	NNS
cord-312386-88uwlmjx	120	8	which	which	WDT
cord-312386-88uwlmjx	120	9	plays	play	VBZ
cord-312386-88uwlmjx	120	10	an	an	DT
cord-312386-88uwlmjx	120	11	important	important	JJ
cord-312386-88uwlmjx	120	12	role	role	NN
cord-312386-88uwlmjx	120	13	in	in	IN
cord-312386-88uwlmjx	120	14	HCV	HCV	NNP
cord-312386-88uwlmjx	120	15	RNA	RNA	NNP
cord-312386-88uwlmjx	120	16	replication	replication	NN
cord-312386-88uwlmjx	120	17	[	[	-LRB-
cord-312386-88uwlmjx	120	18	84	84	CD
cord-312386-88uwlmjx	120	19	]	]	-RRB-
cord-312386-88uwlmjx	120	20	.	.	.
cord-312386-88uwlmjx	121	1	HCV	HCV	NNP
cord-312386-88uwlmjx	121	2	replicon	replicon	NN
cord-312386-88uwlmjx	121	3	-	-	HYPH
cord-312386-88uwlmjx	121	4	expressing	express	VBG
cord-312386-88uwlmjx	121	5	cells	cell	NNS
cord-312386-88uwlmjx	121	6	showed	show	VBD
cord-312386-88uwlmjx	121	7	constitutive	constitutive	JJ
cord-312386-88uwlmjx	121	8	activation	activation	NN
cord-312386-88uwlmjx	121	9	of	of	IN
cord-312386-88uwlmjx	121	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	121	11	which	which	WDT
cord-312386-88uwlmjx	121	12	is	be	VBZ
cord-312386-88uwlmjx	121	13	mediated	mediate	VBN
cord-312386-88uwlmjx	121	14	by	by	IN
cord-312386-88uwlmjx	121	15	oxidative	oxidative	JJ
cord-312386-88uwlmjx	121	16	stress	stress	NN
cord-312386-88uwlmjx	121	17	and	and	CC
cord-312386-88uwlmjx	121	18	influenced	influence	VBN
cord-312386-88uwlmjx	121	19	by	by	IN
cord-312386-88uwlmjx	121	20	the	the	DT
cord-312386-88uwlmjx	121	21	activation	activation	NN
cord-312386-88uwlmjx	121	22	of	of	IN
cord-312386-88uwlmjx	121	23	cellular	cellular	JJ
cord-312386-88uwlmjx	121	24	kinases	kinase	NNS
cord-312386-88uwlmjx	121	25	,	,	,
cord-312386-88uwlmjx	121	26	including	include	VBG
cord-312386-88uwlmjx	121	27	p38	p38	CD
cord-312386-88uwlmjx	121	28	mitogenactivated	mitogenactivated	JJ
cord-312386-88uwlmjx	121	29	protein	protein	NN
cord-312386-88uwlmjx	121	30	kinase	kinase	NN
cord-312386-88uwlmjx	121	31	,	,	,
cord-312386-88uwlmjx	121	32	JNK	JNK	NNP
cord-312386-88uwlmjx	121	33	,	,	,
cord-312386-88uwlmjx	121	34	JAK-2	JAK-2	NNP
cord-312386-88uwlmjx	121	35	,	,	,
cord-312386-88uwlmjx	121	36	and	and	CC
cord-312386-88uwlmjx	121	37	Src	Src	NNP
cord-312386-88uwlmjx	121	38	[	[	-LRB-
cord-312386-88uwlmjx	121	39	84	84	CD
cord-312386-88uwlmjx	121	40	]	]	-RRB-
cord-312386-88uwlmjx	121	41	.	.	.
cord-312386-88uwlmjx	122	1	HCMV	HCMV	NNP
cord-312386-88uwlmjx	122	2	primarily	primarily	RB
cord-312386-88uwlmjx	122	3	utilizes	utilize	VBZ
cord-312386-88uwlmjx	122	4	unphosphorylated	unphosphorylate	VBN
cord-312386-88uwlmjx	122	5	STAT3	STAT3	NNP
cord-312386-88uwlmjx	122	6	to	to	TO
cord-312386-88uwlmjx	122	7	promote	promote	VB
cord-312386-88uwlmjx	122	8	,	,	,
cord-312386-88uwlmjx	122	9	either	either	CC
cord-312386-88uwlmjx	122	10	directly	directly	RB
cord-312386-88uwlmjx	122	11	or	or	CC
cord-312386-88uwlmjx	122	12	indirectly	indirectly	RB
cord-312386-88uwlmjx	122	13	,	,	,
cord-312386-88uwlmjx	122	14	the	the	DT
cord-312386-88uwlmjx	122	15	initiation	initiation	NN
cord-312386-88uwlmjx	122	16	of	of	IN
cord-312386-88uwlmjx	122	17	HCMV	HCMV	NNP
cord-312386-88uwlmjx	122	18	DNA	dna	NN
cord-312386-88uwlmjx	122	19	replication	replication	NN
cord-312386-88uwlmjx	122	20	[	[	-LRB-
cord-312386-88uwlmjx	122	21	77	77	CD
cord-312386-88uwlmjx	122	22	]	]	-RRB-
cord-312386-88uwlmjx	122	23	.	.	.
cord-312386-88uwlmjx	123	1	HCMV	HCMV	NNP
cord-312386-88uwlmjx	123	2	infection	infection	NN
cord-312386-88uwlmjx	123	3	disrupts	disrupt	VBZ
cord-312386-88uwlmjx	123	4	IL-6	IL-6	NNP
cord-312386-88uwlmjx	123	5	induced	induce	VBN
cord-312386-88uwlmjx	123	6	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	123	7	of	of	IN
cord-312386-88uwlmjx	123	8	STAT3	stat3	NN
cord-312386-88uwlmjx	123	9	and	and	CC
cord-312386-88uwlmjx	123	10	expression	expression	NN
cord-312386-88uwlmjx	123	11	of	of	IN
cord-312386-88uwlmjx	123	12	a	a	DT
cord-312386-88uwlmjx	123	13	subset	subset	NN
cord-312386-88uwlmjx	123	14	of	of	IN
cord-312386-88uwlmjx	123	15	IL-6-induced	IL-6-induced	NNP
cord-312386-88uwlmjx	123	16	STAT3-regulated	STAT3-regulated	NNP
cord-312386-88uwlmjx	123	17	genes	gene	NNS
cord-312386-88uwlmjx	123	18	including	include	VBG
cord-312386-88uwlmjx	123	19	SOCS3	socs3	CD
cord-312386-88uwlmjx	123	20	.	.	.
cord-312386-88uwlmjx	124	1	HCMV	HCMV	NNP
cord-312386-88uwlmjx	124	2	72-kDa	72-kda	CD
cord-312386-88uwlmjx	124	3	immediate	immediate	JJ
cord-312386-88uwlmjx	124	4	-	-	HYPH
cord-312386-88uwlmjx	124	5	early	early	JJ
cord-312386-88uwlmjx	124	6	1	1	CD
cord-312386-88uwlmjx	124	7	(	(	-LRB-
cord-312386-88uwlmjx	124	8	IE1	ie1	NN
cord-312386-88uwlmjx	124	9	)	)	-RRB-
cord-312386-88uwlmjx	124	10	protein	protein	NN
cord-312386-88uwlmjx	124	11	associates	associate	NNS
cord-312386-88uwlmjx	124	12	with	with	IN
cord-312386-88uwlmjx	124	13	STAT3	STAT3	NNP
cord-312386-88uwlmjx	124	14	and	and	CC
cord-312386-88uwlmjx	124	15	rapidly	rapidly	RB
cord-312386-88uwlmjx	124	16	promotes	promote	VBZ
cord-312386-88uwlmjx	124	17	nuclear	nuclear	JJ
cord-312386-88uwlmjx	124	18	localization	localization	NN
cord-312386-88uwlmjx	124	19	of	of	IN
cord-312386-88uwlmjx	124	20	STAT3	STAT3	NNP
cord-312386-88uwlmjx	124	21	in	in	IN
cord-312386-88uwlmjx	124	22	the	the	DT
cord-312386-88uwlmjx	124	23	absence	absence	NN
cord-312386-88uwlmjx	124	24	of	of	IN
cord-312386-88uwlmjx	124	25	robust	robust	JJ
cord-312386-88uwlmjx	124	26	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	124	27	at	at	IN
cord-312386-88uwlmjx	124	28	Y705	y705	CD
cord-312386-88uwlmjx	124	29	and	and	CC
cord-312386-88uwlmjx	124	30	inhibition	inhibition	NN
cord-312386-88uwlmjx	124	31	of	of	IN
cord-312386-88uwlmjx	124	32	STAT3	STAT3	NNP
cord-312386-88uwlmjx	124	33	nuclear	nuclear	JJ
cord-312386-88uwlmjx	124	34	localization	localization	NN
cord-312386-88uwlmjx	124	35	or	or	CC
cord-312386-88uwlmjx	124	36	STAT3	stat3	CD
cord-312386-88uwlmjx	124	37	expression	expression	NN
cord-312386-88uwlmjx	124	38	during	during	IN
cord-312386-88uwlmjx	124	39	infection	infection	NN
cord-312386-88uwlmjx	124	40	results	result	NNS
cord-312386-88uwlmjx	124	41	in	in	IN
cord-312386-88uwlmjx	124	42	diminished	diminished	JJ
cord-312386-88uwlmjx	124	43	HCMV	HCMV	NNP
cord-312386-88uwlmjx	124	44	genome	genome	NN
cord-312386-88uwlmjx	124	45	replication	replication	NN
cord-312386-88uwlmjx	124	46	[	[	-LRB-
cord-312386-88uwlmjx	124	47	77	77	CD
cord-312386-88uwlmjx	124	48	]	]	-RRB-
cord-312386-88uwlmjx	124	49	.	.	.
cord-312386-88uwlmjx	125	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	125	2	activation	activation	NN
cord-312386-88uwlmjx	125	3	was	be	VBD
cord-312386-88uwlmjx	125	4	shown	show	VBN
cord-312386-88uwlmjx	125	5	to	to	TO
cord-312386-88uwlmjx	125	6	be	be	VB
cord-312386-88uwlmjx	125	7	critical	critical	JJ
cord-312386-88uwlmjx	125	8	for	for	IN
cord-312386-88uwlmjx	125	9	replication	replication	NN
cord-312386-88uwlmjx	125	10	of	of	IN
cord-312386-88uwlmjx	125	11	VZV	VZV	NNP
cord-312386-88uwlmjx	125	12	that	that	WDT
cord-312386-88uwlmjx	125	13	causes	cause	VBZ
cord-312386-88uwlmjx	125	14	varicella	varicella	NN
cord-312386-88uwlmjx	125	15	(	(	-LRB-
cord-312386-88uwlmjx	125	16	chickenpox	chickenpox	NN
cord-312386-88uwlmjx	125	17	)	)	-RRB-
cord-312386-88uwlmjx	125	18	during	during	IN
cord-312386-88uwlmjx	125	19	primary	primary	JJ
cord-312386-88uwlmjx	125	20	infection	infection	NN
cord-312386-88uwlmjx	125	21	and	and	CC
cord-312386-88uwlmjx	125	22	zoster	zoster	NN
cord-312386-88uwlmjx	125	23	(	(	-LRB-
cord-312386-88uwlmjx	125	24	shingles	shingle	NNS
cord-312386-88uwlmjx	125	25	)	)	-RRB-
cord-312386-88uwlmjx	125	26	upon	upon	IN
cord-312386-88uwlmjx	125	27	reactivation	reactivation	NN
cord-312386-88uwlmjx	125	28	[	[	-LRB-
cord-312386-88uwlmjx	125	29	74	74	CD
cord-312386-88uwlmjx	125	30	]	]	-RRB-
cord-312386-88uwlmjx	125	31	.	.	.
cord-312386-88uwlmjx	126	1	VZV	VZV	NNP
cord-312386-88uwlmjx	126	2	triggers	trigger	VBZ
cord-312386-88uwlmjx	126	3	STAT3	STAT3	VBG
cord-312386-88uwlmjx	126	4	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	126	5	in	in	IN
cord-312386-88uwlmjx	126	6	cells	cell	NNS
cord-312386-88uwlmjx	126	7	infected	infect	VBN
cord-312386-88uwlmjx	126	8	in	in	IN
cord-312386-88uwlmjx	126	9	vitro	vitro	FW
cord-312386-88uwlmjx	126	10	and	and	CC
cord-312386-88uwlmjx	126	11	also	also	RB
cord-312386-88uwlmjx	126	12	in	in	IN
cord-312386-88uwlmjx	126	13	human	human	JJ
cord-312386-88uwlmjx	126	14	skin	skin	NN
cord-312386-88uwlmjx	126	15	xenografts	xenograft	NNS
cord-312386-88uwlmjx	126	16	in	in	IN
cord-312386-88uwlmjx	126	17	SCID	SCID	NNP
cord-312386-88uwlmjx	126	18	mice	mouse	NNS
cord-312386-88uwlmjx	126	19	in	in	IN
cord-312386-88uwlmjx	126	20	vivo	vivo	NNP
cord-312386-88uwlmjx	126	21	.	.	.
cord-312386-88uwlmjx	127	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	127	2	activation	activation	NN
cord-312386-88uwlmjx	127	3	induces	induce	VBZ
cord-312386-88uwlmjx	127	4	the	the	DT
cord-312386-88uwlmjx	127	5	antiapoptotic	antiapoptotic	NNP
cord-312386-88uwlmjx	127	6	protein	protein	NN
cord-312386-88uwlmjx	127	7	survivin	survivin	NN
cord-312386-88uwlmjx	127	8	and	and	CC
cord-312386-88uwlmjx	127	9	both	both	DT
cord-312386-88uwlmjx	127	10	STAT3	stat3	XX
cord-312386-88uwlmjx	127	11	and	and	CC
cord-312386-88uwlmjx	127	12	surviving	survive	VBG
cord-312386-88uwlmjx	127	13	are	be	VBP
cord-312386-88uwlmjx	127	14	essential	essential	JJ
cord-312386-88uwlmjx	127	15	for	for	IN
cord-312386-88uwlmjx	127	16	VZV	VZV	NNP
cord-312386-88uwlmjx	127	17	replication	replication	NN
cord-312386-88uwlmjx	127	18	as	as	IN
cord-312386-88uwlmjx	127	19	inhibition	inhibition	NN
cord-312386-88uwlmjx	127	20	of	of	IN
cord-312386-88uwlmjx	127	21	STAT3	STAT3	NNP
cord-312386-88uwlmjx	127	22	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	127	23	and	and	CC
cord-312386-88uwlmjx	127	24	survivin	survivin	NN
cord-312386-88uwlmjx	127	25	results	result	NNS
cord-312386-88uwlmjx	127	26	in	in	IN
cord-312386-88uwlmjx	127	27	restricted	restrict	VBN
cord-312386-88uwlmjx	127	28	VZV	VZV	NNP
cord-312386-88uwlmjx	127	29	replication	replication	NN
cord-312386-88uwlmjx	127	30	[	[	-LRB-
cord-312386-88uwlmjx	127	31	74	74	CD
cord-312386-88uwlmjx	127	32	]	]	-RRB-
cord-312386-88uwlmjx	127	33	.	.	.
cord-312386-88uwlmjx	128	1	Mumps	mumps	NN
cord-312386-88uwlmjx	128	2	virus	virus	NN
cord-312386-88uwlmjx	128	3	V	v	NN
cord-312386-88uwlmjx	128	4	protein	protein	NN
cord-312386-88uwlmjx	128	5	functions	function	NNS
cord-312386-88uwlmjx	128	6	as	as	IN
cord-312386-88uwlmjx	128	7	a	a	DT
cord-312386-88uwlmjx	128	8	ubiquitin	ubiquitin	NN
cord-312386-88uwlmjx	128	9	ligase	ligase	NN
cord-312386-88uwlmjx	128	10	that	that	WDT
cord-312386-88uwlmjx	128	11	targets	target	VBZ
cord-312386-88uwlmjx	128	12	STAT3	STAT3	NNP
cord-312386-88uwlmjx	128	13	for	for	IN
cord-312386-88uwlmjx	128	14	degradation	degradation	NN
cord-312386-88uwlmjx	128	15	and	and	CC
cord-312386-88uwlmjx	128	16	STAT3	stat3	CD
cord-312386-88uwlmjx	128	17	evasion	evasion	NN
cord-312386-88uwlmjx	128	18	has	have	VBZ
cord-312386-88uwlmjx	128	19	been	be	VBN
cord-312386-88uwlmjx	128	20	proposed	propose	VBN
cord-312386-88uwlmjx	128	21	to	to	TO
cord-312386-88uwlmjx	128	22	be	be	VB
cord-312386-88uwlmjx	128	23	beneficial	beneficial	JJ
cord-312386-88uwlmjx	128	24	to	to	IN
cord-312386-88uwlmjx	128	25	the	the	DT
cord-312386-88uwlmjx	128	26	replication	replication	NN
cord-312386-88uwlmjx	128	27	of	of	IN
cord-312386-88uwlmjx	128	28	Paramyxoviruses	Paramyxoviruses	NNP
cord-312386-88uwlmjx	128	29	[	[	-LRB-
cord-312386-88uwlmjx	128	30	85	85	CD
cord-312386-88uwlmjx	128	31	]	]	-RRB-
cord-312386-88uwlmjx	128	32	.	.	.
cord-312386-88uwlmjx	129	1	Further	further	RB
cord-312386-88uwlmjx	129	2	,	,	,
cord-312386-88uwlmjx	129	3	mumps	mumps	NN
cord-312386-88uwlmjx	129	4	virus	virus	NN
cord-312386-88uwlmjx	129	5	V	v	NN
cord-312386-88uwlmjx	129	6	protein	protein	NN
cord-312386-88uwlmjx	129	7	prevents	prevent	VBZ
cord-312386-88uwlmjx	129	8	responses	response	NNS
cord-312386-88uwlmjx	129	9	to	to	IN
cord-312386-88uwlmjx	129	10	interleukin-6	interleukin-6	NNP
cord-312386-88uwlmjx	129	11	and	and	CC
cord-312386-88uwlmjx	129	12	v	v	LS
cord-312386-88uwlmjx	129	13	-	-	:
cord-312386-88uwlmjx	129	14	Src	Src	NNP
cord-312386-88uwlmjx	129	15	signals	signal	NNS
cord-312386-88uwlmjx	129	16	and	and	CC
cord-312386-88uwlmjx	129	17	can	can	MD
cord-312386-88uwlmjx	129	18	induce	induce	VB
cord-312386-88uwlmjx	129	19	apoptosis	apoptosis	NN
cord-312386-88uwlmjx	129	20	in	in	IN
cord-312386-88uwlmjx	129	21	STAT3-dependent	STAT3-dependent	NNP
cord-312386-88uwlmjx	129	22	multiple	multiple	JJ
cord-312386-88uwlmjx	129	23	myeloma	myeloma	NN
cord-312386-88uwlmjx	129	24	cells	cell	NNS
cord-312386-88uwlmjx	129	25	and	and	CC
cord-312386-88uwlmjx	129	26	transformed	transform	VBN
cord-312386-88uwlmjx	129	27	murine	murine	JJ
cord-312386-88uwlmjx	129	28	fibroblasts	fibroblast	NNS
cord-312386-88uwlmjx	129	29	[	[	-LRB-
cord-312386-88uwlmjx	129	30	85	85	CD
cord-312386-88uwlmjx	129	31	,	,	,
cord-312386-88uwlmjx	129	32	86	86	CD
cord-312386-88uwlmjx	129	33	]	]	-RRB-
cord-312386-88uwlmjx	129	34	.	.	.
cord-312386-88uwlmjx	130	1	In	in	IN
cord-312386-88uwlmjx	130	2	a	a	DT
cord-312386-88uwlmjx	130	3	similar	similar	JJ
cord-312386-88uwlmjx	130	4	fashion	fashion	NN
cord-312386-88uwlmjx	130	5	,	,	,
cord-312386-88uwlmjx	130	6	measles	measles	NN
cord-312386-88uwlmjx	130	7	virus	virus	NN
cord-312386-88uwlmjx	130	8	also	also	RB
cord-312386-88uwlmjx	130	9	interferes	interfere	VBZ
cord-312386-88uwlmjx	130	10	with	with	IN
cord-312386-88uwlmjx	130	11	STAT3	STAT3	NNP
cord-312386-88uwlmjx	130	12	activation	activation	NN
cord-312386-88uwlmjx	130	13	and	and	CC
cord-312386-88uwlmjx	130	14	it	-PRON-	PRP
cord-312386-88uwlmjx	130	15	was	be	VBD
cord-312386-88uwlmjx	130	16	proposed	propose	VBN
cord-312386-88uwlmjx	130	17	that	that	IN
cord-312386-88uwlmjx	130	18	this	this	DT
cord-312386-88uwlmjx	130	19	could	could	MD
cord-312386-88uwlmjx	130	20	provide	provide	VB
cord-312386-88uwlmjx	130	21	several	several	JJ
cord-312386-88uwlmjx	130	22	general	general	JJ
cord-312386-88uwlmjx	130	23	or	or	CC
cord-312386-88uwlmjx	130	24	tissuespecific	tissuespecific	JJ
cord-312386-88uwlmjx	130	25	replication	replication	NN
cord-312386-88uwlmjx	130	26	advantages	advantage	NNS
cord-312386-88uwlmjx	130	27	to	to	IN
cord-312386-88uwlmjx	130	28	the	the	DT
cord-312386-88uwlmjx	130	29	virus	virus	NN
cord-312386-88uwlmjx	130	30	[	[	-LRB-
cord-312386-88uwlmjx	130	31	86	86	CD
cord-312386-88uwlmjx	130	32	]	]	-RRB-
cord-312386-88uwlmjx	130	33	.	.	.
cord-312386-88uwlmjx	131	1	Influenza	Influenza	NNP
cord-312386-88uwlmjx	131	2	A	a	DT
cord-312386-88uwlmjx	131	3	virus	virus	NN
cord-312386-88uwlmjx	131	4	(	(	-LRB-
cord-312386-88uwlmjx	131	5	IAV	IAV	NNP
cord-312386-88uwlmjx	131	6	)	)	-RRB-
cord-312386-88uwlmjx	131	7	NS1	ns1	NN
cord-312386-88uwlmjx	131	8	protein	protein	NN
cord-312386-88uwlmjx	131	9	interferes	interfere	VBZ
cord-312386-88uwlmjx	131	10	with	with	IN
cord-312386-88uwlmjx	131	11	IFN	IFN	NNP
cord-312386-88uwlmjx	131	12	production	production	NN
cord-312386-88uwlmjx	131	13	[	[	-LRB-
cord-312386-88uwlmjx	131	14	87	87	CD
cord-312386-88uwlmjx	131	15	]	]	-RRB-
cord-312386-88uwlmjx	131	16	which	which	WDT
cord-312386-88uwlmjx	131	17	correlates	correlate	VBZ
cord-312386-88uwlmjx	131	18	to	to	IN
cord-312386-88uwlmjx	131	19	reduced	reduce	VBN
cord-312386-88uwlmjx	131	20	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	131	21	of	of	IN
cord-312386-88uwlmjx	131	22	STAT3	STAT3	NNP
cord-312386-88uwlmjx	131	23	.	.	.
cord-312386-88uwlmjx	132	1	Transfection	transfection	NN
cord-312386-88uwlmjx	132	2	of	of	IN
cord-312386-88uwlmjx	132	3	NS1	ns1	NN
cord-312386-88uwlmjx	132	4	from	from	IN
cord-312386-88uwlmjx	132	5	a	a	DT
cord-312386-88uwlmjx	132	6	highly	highly	RB
cord-312386-88uwlmjx	132	7	pathogenic	pathogenic	JJ
cord-312386-88uwlmjx	132	8	avian	avian	JJ
cord-312386-88uwlmjx	132	9	influenza	influenza	NN
cord-312386-88uwlmjx	132	10	(	(	-LRB-
cord-312386-88uwlmjx	132	11	HPAI	HPAI	NNP
cord-312386-88uwlmjx	132	12	)	)	-RRB-
cord-312386-88uwlmjx	133	1	H5N1	H5N1	NNP
cord-312386-88uwlmjx	133	2	virus	virus	NN
cord-312386-88uwlmjx	133	3	in	in	IN
cord-312386-88uwlmjx	133	4	human	human	JJ
cord-312386-88uwlmjx	133	5	lung	lung	NN
cord-312386-88uwlmjx	133	6	epithelial	epithelial	JJ
cord-312386-88uwlmjx	133	7	A549	a549	JJ
cord-312386-88uwlmjx	133	8	cells	cell	NNS
cord-312386-88uwlmjx	133	9	resulted	result	VBD
cord-312386-88uwlmjx	133	10	in	in	IN
cord-312386-88uwlmjx	133	11	a	a	DT
cord-312386-88uwlmjx	133	12	notable	notable	JJ
cord-312386-88uwlmjx	133	13	reduction	reduction	NN
cord-312386-88uwlmjx	133	14	in	in	IN
cord-312386-88uwlmjx	133	15	IFN	IFN	NNP
cord-312386-88uwlmjx	133	16	-	-	HYPH
cord-312386-88uwlmjx	133	17	inducible	inducible	JJ
cord-312386-88uwlmjx	133	18	STAT3	STAT3	NNP
cord-312386-88uwlmjx	133	19	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	133	20	[	[	-LRB-
cord-312386-88uwlmjx	133	21	75	75	CD
cord-312386-88uwlmjx	133	22	]	]	-RRB-
cord-312386-88uwlmjx	133	23	.	.	.
cord-312386-88uwlmjx	134	1	Viruses	virus	NNS
cord-312386-88uwlmjx	134	2	such	such	JJ
cord-312386-88uwlmjx	134	3	as	as	IN
cord-312386-88uwlmjx	134	4	HBV	HBV	NNP
cord-312386-88uwlmjx	134	5	,	,	,
cord-312386-88uwlmjx	134	6	HCV	HCV	NNP
cord-312386-88uwlmjx	134	7	,	,	,
cord-312386-88uwlmjx	134	8	and	and	CC
cord-312386-88uwlmjx	134	9	HCMV	HCMV	NNP
cord-312386-88uwlmjx	134	10	appear	appear	VBP
cord-312386-88uwlmjx	134	11	to	to	TO
cord-312386-88uwlmjx	134	12	exploit	exploit	VB
cord-312386-88uwlmjx	134	13	host	host	NN
cord-312386-88uwlmjx	134	14	genes	gene	NNS
cord-312386-88uwlmjx	134	15	transcriptionally	transcriptionally	RB
cord-312386-88uwlmjx	134	16	regulated	regulate	VBN
cord-312386-88uwlmjx	134	17	by	by	IN
cord-312386-88uwlmjx	134	18	STAT3	STAT3	NNP
cord-312386-88uwlmjx	134	19	for	for	IN
cord-312386-88uwlmjx	134	20	their	-PRON-	PRP$
cord-312386-88uwlmjx	134	21	gene	gene	NN
cord-312386-88uwlmjx	134	22	replication	replication	NN
cord-312386-88uwlmjx	134	23	which	which	WDT
cord-312386-88uwlmjx	134	24	could	could	MD
cord-312386-88uwlmjx	134	25	be	be	VB
cord-312386-88uwlmjx	134	26	independent	independent	JJ
cord-312386-88uwlmjx	134	27	of	of	IN
cord-312386-88uwlmjx	134	28	the	the	DT
cord-312386-88uwlmjx	134	29	regulatory	regulatory	JJ
cord-312386-88uwlmjx	134	30	effects	effect	NNS
cord-312386-88uwlmjx	134	31	of	of	IN
cord-312386-88uwlmjx	134	32	STAT3	STAT3	NNP
cord-312386-88uwlmjx	134	33	on	on	IN
cord-312386-88uwlmjx	134	34	type	type	NN
cord-312386-88uwlmjx	134	35	1	1	CD
cord-312386-88uwlmjx	134	36	IFN	IFN	NNP
cord-312386-88uwlmjx	134	37	response	response	NN
cord-312386-88uwlmjx	134	38	.	.	.
cord-312386-88uwlmjx	135	1	Whereas	whereas	IN
cord-312386-88uwlmjx	135	2	STAT3	STAT3	NNP
cord-312386-88uwlmjx	135	3	inhibition	inhibition	NN
cord-312386-88uwlmjx	135	4	appears	appear	VBZ
cord-312386-88uwlmjx	135	5	to	to	TO
cord-312386-88uwlmjx	135	6	be	be	VB
cord-312386-88uwlmjx	135	7	a	a	DT
cord-312386-88uwlmjx	135	8	strategy	strategy	NN
cord-312386-88uwlmjx	135	9	of	of	IN
cord-312386-88uwlmjx	135	10	viruses	virus	NNS
cord-312386-88uwlmjx	135	11	such	such	JJ
cord-312386-88uwlmjx	135	12	as	as	IN
cord-312386-88uwlmjx	135	13	Paramyxo	Paramyxo	NNP
cord-312386-88uwlmjx	135	14	-	-	:
cord-312386-88uwlmjx	135	15	and	and	CC
cord-312386-88uwlmjx	135	16	Orthomyxoviruses	Orthomyxoviruses	NNP
cord-312386-88uwlmjx	135	17	to	to	TO
cord-312386-88uwlmjx	135	18	evade	evade	VB
cord-312386-88uwlmjx	135	19	host	host	NN
cord-312386-88uwlmjx	135	20	innate	innate	JJ
cord-312386-88uwlmjx	135	21	and	and	CC
cord-312386-88uwlmjx	135	22	adaptive	adaptive	JJ
cord-312386-88uwlmjx	135	23	immune	immune	JJ
cord-312386-88uwlmjx	135	24	responses	response	NNS
cord-312386-88uwlmjx	135	25	,	,	,
cord-312386-88uwlmjx	135	26	it	-PRON-	PRP
cord-312386-88uwlmjx	135	27	is	be	VBZ
cord-312386-88uwlmjx	135	28	plausible	plausible	JJ
cord-312386-88uwlmjx	135	29	that	that	IN
cord-312386-88uwlmjx	135	30	inhibition	inhibition	NN
cord-312386-88uwlmjx	135	31	of	of	IN
cord-312386-88uwlmjx	135	32	STAT3	STAT3	NNP
cord-312386-88uwlmjx	135	33	signalling	signalling	NN
cord-312386-88uwlmjx	135	34	could	could	MD
cord-312386-88uwlmjx	135	35	provide	provide	VB
cord-312386-88uwlmjx	135	36	a	a	DT
cord-312386-88uwlmjx	135	37	much	much	RB
cord-312386-88uwlmjx	135	38	broader	broad	JJR
cord-312386-88uwlmjx	135	39	spectrum	spectrum	NN
cord-312386-88uwlmjx	135	40	of	of	IN
cord-312386-88uwlmjx	135	41	cytokine	cytokine	NN
cord-312386-88uwlmjx	135	42	and	and	CC
cord-312386-88uwlmjx	135	43	growth	growth	NN
cord-312386-88uwlmjx	135	44	factor	factor	NN
cord-312386-88uwlmjx	135	45	suppression	suppression	NN
cord-312386-88uwlmjx	135	46	to	to	TO
cord-312386-88uwlmjx	135	47	allow	allow	VB
cord-312386-88uwlmjx	135	48	replication	replication	NN
cord-312386-88uwlmjx	135	49	and	and	CC
cord-312386-88uwlmjx	135	50	spread	spread	NN
cord-312386-88uwlmjx	135	51	of	of	IN
cord-312386-88uwlmjx	135	52	these	these	DT
cord-312386-88uwlmjx	135	53	viruses	virus	NNS
cord-312386-88uwlmjx	135	54	in	in	IN
cord-312386-88uwlmjx	135	55	vivo	vivo	NN
cord-312386-88uwlmjx	135	56	.	.	.
cord-312386-88uwlmjx	136	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	137	1	role	role	NN
cord-312386-88uwlmjx	137	2	in	in	IN
cord-312386-88uwlmjx	137	3	viral	viral	JJ
cord-312386-88uwlmjx	137	4	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	137	5	appears	appear	VBZ
cord-312386-88uwlmjx	137	6	to	to	TO
cord-312386-88uwlmjx	137	7	be	be	VB
cord-312386-88uwlmjx	137	8	complex	complex	JJ
cord-312386-88uwlmjx	137	9	with	with	IN
cord-312386-88uwlmjx	137	10	reports	report	NNS
cord-312386-88uwlmjx	137	11	suggesting	suggest	VBG
cord-312386-88uwlmjx	137	12	both	both	DT
cord-312386-88uwlmjx	137	13	promotion	promotion	NN
cord-312386-88uwlmjx	137	14	of	of	IN
cord-312386-88uwlmjx	137	15	innate	innate	JJ
cord-312386-88uwlmjx	137	16	antiviral	antiviral	JJ
cord-312386-88uwlmjx	137	17	response	response	NN
cord-312386-88uwlmjx	137	18	and	and	CC
cord-312386-88uwlmjx	137	19	contribution	contribution	NN
cord-312386-88uwlmjx	137	20	to	to	IN
cord-312386-88uwlmjx	137	21	the	the	DT
cord-312386-88uwlmjx	137	22	detrimental	detrimental	JJ
cord-312386-88uwlmjx	137	23	effects	effect	NNS
cord-312386-88uwlmjx	137	24	of	of	IN
cord-312386-88uwlmjx	137	25	viral	viral	JJ
cord-312386-88uwlmjx	137	26	infection	infection	NN
cord-312386-88uwlmjx	137	27	.	.	.
cord-312386-88uwlmjx	138	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	138	2	is	be	VBZ
cord-312386-88uwlmjx	138	3	constitutively	constitutively	RB
cord-312386-88uwlmjx	138	4	phosphorylated	phosphorylate	VBN
cord-312386-88uwlmjx	138	5	in	in	IN
cord-312386-88uwlmjx	138	6	neoplastic	neoplastic	JJ
cord-312386-88uwlmjx	138	7	cells	cell	NNS
cord-312386-88uwlmjx	138	8	[	[	-LRB-
cord-312386-88uwlmjx	138	9	88	88	CD
cord-312386-88uwlmjx	138	10	]	]	-RRB-
cord-312386-88uwlmjx	138	11	and	and	CC
cord-312386-88uwlmjx	138	12	many	many	JJ
cord-312386-88uwlmjx	138	13	viruses	virus	NNS
cord-312386-88uwlmjx	138	14	exploit	exploit	VBP
cord-312386-88uwlmjx	138	15	the	the	DT
cord-312386-88uwlmjx	138	16	oncogenic	oncogenic	JJ
cord-312386-88uwlmjx	138	17	effects	effect	NNS
cord-312386-88uwlmjx	138	18	of	of	IN
cord-312386-88uwlmjx	138	19	phosphorylated	phosphorylated	JJ
cord-312386-88uwlmjx	138	20	STAT3	STAT3	NNP
cord-312386-88uwlmjx	138	21	(	(	-LRB-
cord-312386-88uwlmjx	138	22	pSTAT3	pstat3	CD
cord-312386-88uwlmjx	138	23	)	)	-RRB-
cord-312386-88uwlmjx	138	24	.	.	.
cord-312386-88uwlmjx	139	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	139	2	plays	play	VBZ
cord-312386-88uwlmjx	139	3	a	a	DT
cord-312386-88uwlmjx	139	4	central	central	JJ
cord-312386-88uwlmjx	139	5	role	role	NN
cord-312386-88uwlmjx	139	6	in	in	IN
cord-312386-88uwlmjx	139	7	the	the	DT
cord-312386-88uwlmjx	139	8	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	139	9	of	of	IN
cord-312386-88uwlmjx	139	10	oncogenic	oncogenic	JJ
cord-312386-88uwlmjx	139	11	viruses	virus	NNS
cord-312386-88uwlmjx	139	12	such	such	JJ
cord-312386-88uwlmjx	139	13	6	6	CD
cord-312386-88uwlmjx	139	14	Journal	Journal	NNP
cord-312386-88uwlmjx	139	15	of	of	IN
cord-312386-88uwlmjx	139	16	Immunology	Immunology	NNP
cord-312386-88uwlmjx	139	17	Research	Research	NNP
cord-312386-88uwlmjx	139	18	as	as	IN
cord-312386-88uwlmjx	139	19	the	the	DT
cord-312386-88uwlmjx	139	20	-herpesviruses	-herpesviruse	NNS
cord-312386-88uwlmjx	139	21	,	,	,
cord-312386-88uwlmjx	139	22	KSHV	KSHV	NNP
cord-312386-88uwlmjx	139	23	,	,	,
cord-312386-88uwlmjx	139	24	EBV	EBV	NNP
cord-312386-88uwlmjx	139	25	,	,	,
cord-312386-88uwlmjx	139	26	and	and	CC
cord-312386-88uwlmjx	139	27	Herpesvirus	Herpesvirus	NNP
cord-312386-88uwlmjx	139	28	saimiri	saimiri	NNP
cord-312386-88uwlmjx	139	29	[	[	-LRB-
cord-312386-88uwlmjx	139	30	72	72	CD
cord-312386-88uwlmjx	139	31	,	,	,
cord-312386-88uwlmjx	139	32	73	73	CD
cord-312386-88uwlmjx	139	33	,	,	,
cord-312386-88uwlmjx	139	34	89	89	CD
cord-312386-88uwlmjx	139	35	]	]	-RRB-
cord-312386-88uwlmjx	139	36	.	.	.
cord-312386-88uwlmjx	140	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	141	1	role	role	NN
cord-312386-88uwlmjx	141	2	has	have	VBZ
cord-312386-88uwlmjx	141	3	been	be	VBN
cord-312386-88uwlmjx	141	4	well	well	RB
cord-312386-88uwlmjx	141	5	characterized	characterize	VBN
cord-312386-88uwlmjx	141	6	in	in	IN
cord-312386-88uwlmjx	141	7	the	the	DT
cord-312386-88uwlmjx	141	8	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	141	9	of	of	IN
cord-312386-88uwlmjx	141	10	viral	viral	JJ
cord-312386-88uwlmjx	141	11	infections	infection	NNS
cord-312386-88uwlmjx	141	12	resulting	result	VBG
cord-312386-88uwlmjx	141	13	in	in	IN
cord-312386-88uwlmjx	141	14	liver	liver	NN
cord-312386-88uwlmjx	141	15	disease	disease	NN
cord-312386-88uwlmjx	141	16	in	in	IN
cord-312386-88uwlmjx	141	17	humans	human	NNS
cord-312386-88uwlmjx	141	18	.	.	.
cord-312386-88uwlmjx	142	1	HCV	HCV	NNP
cord-312386-88uwlmjx	142	2	infection	infection	NN
cord-312386-88uwlmjx	142	3	in	in	IN
cord-312386-88uwlmjx	142	4	liver	liver	NN
cord-312386-88uwlmjx	142	5	cells	cell	NNS
cord-312386-88uwlmjx	142	6	causes	cause	VBZ
cord-312386-88uwlmjx	142	7	constitutive	constitutive	JJ
cord-312386-88uwlmjx	142	8	activation	activation	NN
cord-312386-88uwlmjx	142	9	of	of	IN
cord-312386-88uwlmjx	142	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	142	11	,	,	,
cord-312386-88uwlmjx	142	12	which	which	WDT
cord-312386-88uwlmjx	142	13	plays	play	VBZ
cord-312386-88uwlmjx	142	14	a	a	DT
cord-312386-88uwlmjx	142	15	central	central	JJ
cord-312386-88uwlmjx	142	16	role	role	NN
cord-312386-88uwlmjx	142	17	in	in	IN
cord-312386-88uwlmjx	142	18	chronic	chronic	JJ
cord-312386-88uwlmjx	142	19	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	142	20	and	and	CC
cord-312386-88uwlmjx	142	21	often	often	RB
cord-312386-88uwlmjx	142	22	results	result	VBZ
cord-312386-88uwlmjx	142	23	in	in	IN
cord-312386-88uwlmjx	142	24	liver	liver	NN
cord-312386-88uwlmjx	142	25	cirrhosis	cirrhosis	NN
cord-312386-88uwlmjx	142	26	and	and	CC
cord-312386-88uwlmjx	142	27	hepatocellular	hepatocellular	JJ
cord-312386-88uwlmjx	142	28	carcinoma	carcinoma	NN
cord-312386-88uwlmjx	142	29	[	[	-LRB-
cord-312386-88uwlmjx	142	30	84	84	CD
cord-312386-88uwlmjx	142	31	]	]	-RRB-
cord-312386-88uwlmjx	142	32	.	.	.
cord-312386-88uwlmjx	143	1	HCV	HCV	NNP
cord-312386-88uwlmjx	143	2	core	core	NN
cord-312386-88uwlmjx	143	3	protein	protein	NN
cord-312386-88uwlmjx	143	4	directly	directly	RB
cord-312386-88uwlmjx	143	5	interacts	interact	VBZ
cord-312386-88uwlmjx	143	6	with	with	IN
cord-312386-88uwlmjx	143	7	and	and	CC
cord-312386-88uwlmjx	143	8	activates	activate	VBZ
cord-312386-88uwlmjx	143	9	STAT3	STAT3	VBN
cord-312386-88uwlmjx	143	10	through	through	IN
cord-312386-88uwlmjx	143	11	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	143	12	of	of	IN
cord-312386-88uwlmjx	143	13	the	the	DT
cord-312386-88uwlmjx	143	14	critical	critical	JJ
cord-312386-88uwlmjx	143	15	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	143	16	and	and	CC
cord-312386-88uwlmjx	143	17	is	be	VBZ
cord-312386-88uwlmjx	143	18	responsible	responsible	JJ
cord-312386-88uwlmjx	143	19	for	for	IN
cord-312386-88uwlmjx	143	20	the	the	DT
cord-312386-88uwlmjx	143	21	virus	virus	NN
cord-312386-88uwlmjx	143	22	-	-	HYPH
cord-312386-88uwlmjx	143	23	induced	induce	VBN
cord-312386-88uwlmjx	143	24	transformation	transformation	NN
cord-312386-88uwlmjx	143	25	.	.	.
cord-312386-88uwlmjx	144	1	Activation	activation	NN
cord-312386-88uwlmjx	144	2	of	of	IN
cord-312386-88uwlmjx	144	3	STAT3	STAT3	NNP
cord-312386-88uwlmjx	144	4	by	by	IN
cord-312386-88uwlmjx	144	5	the	the	DT
cord-312386-88uwlmjx	144	6	HCV	HCV	NNP
cord-312386-88uwlmjx	144	7	core	core	NN
cord-312386-88uwlmjx	144	8	results	result	NNS
cord-312386-88uwlmjx	144	9	in	in	IN
cord-312386-88uwlmjx	144	10	rapid	rapid	JJ
cord-312386-88uwlmjx	144	11	proliferation	proliferation	NN
cord-312386-88uwlmjx	144	12	and	and	CC
cord-312386-88uwlmjx	144	13	upregulation	upregulation	NN
cord-312386-88uwlmjx	144	14	of	of	IN
cord-312386-88uwlmjx	144	15	Bcl	Bcl	NNP
cord-312386-88uwlmjx	144	16	-	-	HYPH
cord-312386-88uwlmjx	144	17	XL	XL	NNP
cord-312386-88uwlmjx	144	18	and	and	CC
cord-312386-88uwlmjx	144	19	cyclin	cyclin	NN
cord-312386-88uwlmjx	144	20	-	-	HYPH
cord-312386-88uwlmjx	144	21	D1	d1	NN
cord-312386-88uwlmjx	144	22	and	and	CC
cord-312386-88uwlmjx	144	23	additional	additional	JJ
cord-312386-88uwlmjx	144	24	expression	expression	NN
cord-312386-88uwlmjx	144	25	of	of	IN
cord-312386-88uwlmjx	144	26	STAT3	STAT3	NNP
cord-312386-88uwlmjx	144	27	in	in	IN
cord-312386-88uwlmjx	144	28	HCV	HCV	NNP
cord-312386-88uwlmjx	144	29	core	core	NN
cord-312386-88uwlmjx	144	30	-	-	HYPH
cord-312386-88uwlmjx	144	31	expressing	express	VBG
cord-312386-88uwlmjx	144	32	cells	cell	NNS
cord-312386-88uwlmjx	144	33	results	result	NNS
cord-312386-88uwlmjx	144	34	in	in	IN
cord-312386-88uwlmjx	144	35	anchorage	anchorage	NN
cord-312386-88uwlmjx	144	36	-	-	HYPH
cord-312386-88uwlmjx	144	37	independent	independent	JJ
cord-312386-88uwlmjx	144	38	growth	growth	NN
cord-312386-88uwlmjx	144	39	and	and	CC
cord-312386-88uwlmjx	144	40	tumorigenesis	tumorigenesis	NN
cord-312386-88uwlmjx	144	41	[	[	-LRB-
cord-312386-88uwlmjx	144	42	90	90	CD
cord-312386-88uwlmjx	144	43	]	]	-RRB-
cord-312386-88uwlmjx	144	44	.	.	.
cord-312386-88uwlmjx	145	1	Cytokine	cytokine	JJ
cord-312386-88uwlmjx	145	2	stimulation	stimulation	NN
cord-312386-88uwlmjx	145	3	of	of	IN
cord-312386-88uwlmjx	145	4	HBV	HBV	NNP
cord-312386-88uwlmjx	145	5	gene	gene	NN
cord-312386-88uwlmjx	145	6	expression	expression	NN
cord-312386-88uwlmjx	145	7	represents	represent	VBZ
cord-312386-88uwlmjx	145	8	an	an	DT
cord-312386-88uwlmjx	145	9	important	important	JJ
cord-312386-88uwlmjx	145	10	regulatory	regulatory	JJ
cord-312386-88uwlmjx	145	11	scheme	scheme	NN
cord-312386-88uwlmjx	145	12	of	of	IN
cord-312386-88uwlmjx	145	13	direct	direct	JJ
cord-312386-88uwlmjx	145	14	relevance	relevance	NN
cord-312386-88uwlmjx	145	15	to	to	IN
cord-312386-88uwlmjx	145	16	the	the	DT
cord-312386-88uwlmjx	145	17	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	145	18	of	of	IN
cord-312386-88uwlmjx	145	19	liver	liver	NN
cord-312386-88uwlmjx	145	20	disease	disease	NN
cord-312386-88uwlmjx	145	21	associated	associate	VBN
cord-312386-88uwlmjx	145	22	with	with	IN
cord-312386-88uwlmjx	145	23	HBV	HBV	NNP
cord-312386-88uwlmjx	145	24	infection	infection	NN
cord-312386-88uwlmjx	145	25	[	[	-LRB-
cord-312386-88uwlmjx	145	26	83	83	CD
cord-312386-88uwlmjx	145	27	]	]	-RRB-
cord-312386-88uwlmjx	145	28	.	.	.
cord-312386-88uwlmjx	146	1	HCMV	HCMV	NNP
cord-312386-88uwlmjx	146	2	infection	infection	NN
cord-312386-88uwlmjx	146	3	of	of	IN
cord-312386-88uwlmjx	146	4	PHH	PHH	NNP
cord-312386-88uwlmjx	146	5	and	and	CC
cord-312386-88uwlmjx	146	6	HepG2	HepG2	NNP
cord-312386-88uwlmjx	146	7	cells	cell	NNS
cord-312386-88uwlmjx	146	8	results	result	NNS
cord-312386-88uwlmjx	146	9	in	in	IN
cord-312386-88uwlmjx	146	10	activation	activation	NN
cord-312386-88uwlmjx	146	11	of	of	IN
cord-312386-88uwlmjx	146	12	the	the	DT
cord-312386-88uwlmjx	146	13	IL-6-JAK	il-6-jak	NN
cord-312386-88uwlmjx	146	14	-	-	HYPH
cord-312386-88uwlmjx	146	15	STAT3	STAT3	NNP
cord-312386-88uwlmjx	146	16	pathway	pathway	NN
cord-312386-88uwlmjx	146	17	which	which	WDT
cord-312386-88uwlmjx	146	18	results	result	VBZ
cord-312386-88uwlmjx	146	19	in	in	IN
cord-312386-88uwlmjx	146	20	the	the	DT
cord-312386-88uwlmjx	146	21	transformation	transformation	NN
cord-312386-88uwlmjx	146	22	of	of	IN
cord-312386-88uwlmjx	146	23	PHH	PHH	NNP
cord-312386-88uwlmjx	146	24	cells	cell	NNS
cord-312386-88uwlmjx	146	25	and	and	CC
cord-312386-88uwlmjx	146	26	enhanced	enhance	VBN
cord-312386-88uwlmjx	146	27	HepG2	HepG2	NNP
cord-312386-88uwlmjx	146	28	tumorsphere	tumorsphere	NN
cord-312386-88uwlmjx	146	29	formation	formation	NN
cord-312386-88uwlmjx	146	30	raising	raise	VBG
cord-312386-88uwlmjx	146	31	the	the	DT
cord-312386-88uwlmjx	146	32	possibility	possibility	NN
cord-312386-88uwlmjx	146	33	that	that	IN
cord-312386-88uwlmjx	146	34	HCMV	HCMV	NNP
cord-312386-88uwlmjx	146	35	infection	infection	NN
cord-312386-88uwlmjx	146	36	might	may	MD
cord-312386-88uwlmjx	146	37	be	be	VB
cord-312386-88uwlmjx	146	38	involved	involve	VBN
cord-312386-88uwlmjx	146	39	in	in	IN
cord-312386-88uwlmjx	146	40	the	the	DT
cord-312386-88uwlmjx	146	41	genesis	genesis	NN
cord-312386-88uwlmjx	146	42	of	of	IN
cord-312386-88uwlmjx	146	43	hepatocellular	hepatocellular	JJ
cord-312386-88uwlmjx	146	44	carcinoma	carcinoma	NN
cord-312386-88uwlmjx	146	45	[	[	-LRB-
cord-312386-88uwlmjx	146	46	91	91	CD
cord-312386-88uwlmjx	146	47	]	]	-RRB-
cord-312386-88uwlmjx	146	48	.	.	.
cord-312386-88uwlmjx	147	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	147	2	activation	activation	NN
cord-312386-88uwlmjx	147	3	and	and	CC
cord-312386-88uwlmjx	147	4	upregulation	upregulation	NN
cord-312386-88uwlmjx	147	5	of	of	IN
cord-312386-88uwlmjx	147	6	antiapoptotic	antiapoptotic	NNP
cord-312386-88uwlmjx	147	7	protein	protein	NN
cord-312386-88uwlmjx	147	8	survivin	survivin	NN
cord-312386-88uwlmjx	147	9	play	play	VBP
cord-312386-88uwlmjx	147	10	an	an	DT
cord-312386-88uwlmjx	147	11	important	important	JJ
cord-312386-88uwlmjx	147	12	role	role	NN
cord-312386-88uwlmjx	147	13	in	in	IN
cord-312386-88uwlmjx	147	14	the	the	DT
cord-312386-88uwlmjx	147	15	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	147	16	of	of	IN
cord-312386-88uwlmjx	147	17	lytic	lytic	JJ
cord-312386-88uwlmjx	147	18	as	as	RB
cord-312386-88uwlmjx	147	19	well	well	RB
cord-312386-88uwlmjx	147	20	as	as	IN
cord-312386-88uwlmjx	147	21	tumorigenic	tumorigenic	NNP
cord-312386-88uwlmjx	147	22	herpesviruses	herpesviruses	NNP
cord-312386-88uwlmjx	147	23	[	[	-LRB-
cord-312386-88uwlmjx	147	24	74	74	CD
cord-312386-88uwlmjx	147	25	]	]	-RRB-
cord-312386-88uwlmjx	147	26	.	.	.
cord-312386-88uwlmjx	148	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	148	2	and	and	CC
cord-312386-88uwlmjx	148	3	survivin	survivin	NN
cord-312386-88uwlmjx	148	4	have	have	VBP
cord-312386-88uwlmjx	148	5	been	be	VBN
cord-312386-88uwlmjx	148	6	shown	show	VBN
cord-312386-88uwlmjx	148	7	to	to	TO
cord-312386-88uwlmjx	148	8	play	play	VB
cord-312386-88uwlmjx	148	9	a	a	DT
cord-312386-88uwlmjx	148	10	major	major	JJ
cord-312386-88uwlmjx	148	11	role	role	NN
cord-312386-88uwlmjx	148	12	in	in	IN
cord-312386-88uwlmjx	148	13	the	the	DT
cord-312386-88uwlmjx	148	14	malignant	malignant	JJ
cord-312386-88uwlmjx	148	15	transformation	transformation	NN
cord-312386-88uwlmjx	148	16	of	of	IN
cord-312386-88uwlmjx	148	17	cells	cell	NNS
cord-312386-88uwlmjx	148	18	infected	infect	VBN
cord-312386-88uwlmjx	148	19	by	by	IN
cord-312386-88uwlmjx	148	20	-herpesviruses	-herpesviruse	NNS
cord-312386-88uwlmjx	148	21	,	,	,
cord-312386-88uwlmjx	148	22	such	such	JJ
cord-312386-88uwlmjx	148	23	as	as	IN
cord-312386-88uwlmjx	148	24	KSHV	KSHV	NNP
cord-312386-88uwlmjx	148	25	[	[	-LRB-
cord-312386-88uwlmjx	148	26	72	72	CD
cord-312386-88uwlmjx	148	27	]	]	-RRB-
cord-312386-88uwlmjx	148	28	.	.	.
cord-312386-88uwlmjx	149	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	149	2	activation	activation	NN
cord-312386-88uwlmjx	149	3	is	be	VBZ
cord-312386-88uwlmjx	149	4	essential	essential	JJ
cord-312386-88uwlmjx	149	5	for	for	IN
cord-312386-88uwlmjx	149	6	the	the	DT
cord-312386-88uwlmjx	149	7	skin	skin	NN
cord-312386-88uwlmjx	149	8	infections	infection	NNS
cord-312386-88uwlmjx	149	9	caused	cause	VBN
cord-312386-88uwlmjx	149	10	by	by	IN
cord-312386-88uwlmjx	149	11	VZV	VZV	NNP
cord-312386-88uwlmjx	149	12	which	which	WDT
cord-312386-88uwlmjx	149	13	is	be	VBZ
cord-312386-88uwlmjx	149	14	necessary	necessary	JJ
cord-312386-88uwlmjx	149	15	for	for	IN
cord-312386-88uwlmjx	149	16	viral	viral	JJ
cord-312386-88uwlmjx	149	17	transmission	transmission	NN
cord-312386-88uwlmjx	149	18	and	and	CC
cord-312386-88uwlmjx	149	19	persistence	persistence	NN
cord-312386-88uwlmjx	149	20	in	in	IN
cord-312386-88uwlmjx	149	21	the	the	DT
cord-312386-88uwlmjx	149	22	human	human	JJ
cord-312386-88uwlmjx	149	23	population	population	NN
cord-312386-88uwlmjx	149	24	[	[	-LRB-
cord-312386-88uwlmjx	149	25	74	74	CD
cord-312386-88uwlmjx	149	26	]	]	-RRB-
cord-312386-88uwlmjx	149	27	.	.	.
cord-312386-88uwlmjx	150	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	150	2	is	be	VBZ
cord-312386-88uwlmjx	150	3	also	also	RB
cord-312386-88uwlmjx	150	4	known	know	VBN
cord-312386-88uwlmjx	150	5	to	to	TO
cord-312386-88uwlmjx	150	6	promote	promote	VB
cord-312386-88uwlmjx	150	7	host	host	NN
cord-312386-88uwlmjx	150	8	defense	defense	NN
cord-312386-88uwlmjx	150	9	against	against	IN
cord-312386-88uwlmjx	150	10	virus	virus	NN
cord-312386-88uwlmjx	150	11	infections	infection	NNS
cord-312386-88uwlmjx	150	12	and	and	CC
cord-312386-88uwlmjx	150	13	play	play	VB
cord-312386-88uwlmjx	150	14	a	a	DT
cord-312386-88uwlmjx	150	15	protective	protective	JJ
cord-312386-88uwlmjx	150	16	role	role	NN
cord-312386-88uwlmjx	150	17	in	in	IN
cord-312386-88uwlmjx	150	18	regulating	regulate	VBG
cord-312386-88uwlmjx	150	19	virus	virus	NN
cord-312386-88uwlmjx	150	20	mediated	mediate	VBN
cord-312386-88uwlmjx	150	21	proinflammation	proinflammation	NN
cord-312386-88uwlmjx	150	22	.	.	.
cord-312386-88uwlmjx	151	1	Gp130-STAT3	Gp130-STAT3	NNP
cord-312386-88uwlmjx	152	1	signalling	signalling	NN
cord-312386-88uwlmjx	152	2	plays	play	VBZ
cord-312386-88uwlmjx	152	3	an	an	DT
cord-312386-88uwlmjx	152	4	important	important	JJ
cord-312386-88uwlmjx	152	5	role	role	NN
cord-312386-88uwlmjx	152	6	in	in	IN
cord-312386-88uwlmjx	152	7	the	the	DT
cord-312386-88uwlmjx	152	8	innate	innate	JJ
cord-312386-88uwlmjx	152	9	immune	immune	JJ
cord-312386-88uwlmjx	152	10	response	response	NN
cord-312386-88uwlmjx	152	11	in	in	IN
cord-312386-88uwlmjx	152	12	cardiac	cardiac	JJ
cord-312386-88uwlmjx	152	13	myocytes	myocyte	NNS
cord-312386-88uwlmjx	152	14	against	against	IN
cord-312386-88uwlmjx	152	15	coxsackievirus	coxsackievirus	NNP
cord-312386-88uwlmjx	152	16	B3	B3	NNP
cord-312386-88uwlmjx	152	17	infection	infection	NN
cord-312386-88uwlmjx	152	18	[	[	-LRB-
cord-312386-88uwlmjx	152	19	92	92	CD
cord-312386-88uwlmjx	152	20	]	]	-RRB-
cord-312386-88uwlmjx	152	21	.	.	.
cord-312386-88uwlmjx	153	1	Dysregulation	Dysregulation	NNP
cord-312386-88uwlmjx	153	2	of	of	IN
cord-312386-88uwlmjx	153	3	host	host	NN
cord-312386-88uwlmjx	153	4	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	153	5	response	response	NN
cord-312386-88uwlmjx	153	6	is	be	VBZ
cord-312386-88uwlmjx	153	7	a	a	DT
cord-312386-88uwlmjx	153	8	key	key	JJ
cord-312386-88uwlmjx	153	9	contributing	contribute	VBG
cord-312386-88uwlmjx	153	10	factor	factor	NN
cord-312386-88uwlmjx	153	11	to	to	IN
cord-312386-88uwlmjx	153	12	the	the	DT
cord-312386-88uwlmjx	153	13	morbidity	morbidity	NN
cord-312386-88uwlmjx	153	14	and	and	CC
cord-312386-88uwlmjx	153	15	mortality	mortality	NN
cord-312386-88uwlmjx	153	16	of	of	IN
cord-312386-88uwlmjx	153	17	virulent	virulent	JJ
cord-312386-88uwlmjx	153	18	influenza	influenza	NN
cord-312386-88uwlmjx	153	19	virus	virus	NN
cord-312386-88uwlmjx	153	20	infections	infection	NNS
cord-312386-88uwlmjx	153	21	such	such	JJ
cord-312386-88uwlmjx	153	22	as	as	IN
cord-312386-88uwlmjx	153	23	the	the	DT
cord-312386-88uwlmjx	153	24	highly	highly	RB
cord-312386-88uwlmjx	153	25	pathogenic	pathogenic	JJ
cord-312386-88uwlmjx	153	26	avian	avian	JJ
cord-312386-88uwlmjx	153	27	influenza	influenza	NN
cord-312386-88uwlmjx	153	28	(	(	-LRB-
cord-312386-88uwlmjx	153	29	HPAI	HPAI	NNP
cord-312386-88uwlmjx	153	30	)	)	-RRB-
cord-312386-88uwlmjx	154	1	H5N1	H5N1	NNP
cord-312386-88uwlmjx	154	2	viruses	virus	NNS
cord-312386-88uwlmjx	154	3	[	[	-LRB-
cord-312386-88uwlmjx	154	4	93	93	CD
cord-312386-88uwlmjx	154	5	]	]	-RRB-
cord-312386-88uwlmjx	154	6	[	[	-LRB-
cord-312386-88uwlmjx	154	7	94	94	CD
cord-312386-88uwlmjx	154	8	]	]	-RRB-
cord-312386-88uwlmjx	154	9	[	[	-LRB-
cord-312386-88uwlmjx	154	10	95	95	CD
cord-312386-88uwlmjx	154	11	]	]	-RRB-
cord-312386-88uwlmjx	154	12	[	[	-LRB-
cord-312386-88uwlmjx	154	13	96	96	CD
cord-312386-88uwlmjx	154	14	]	]	-RRB-
cord-312386-88uwlmjx	154	15	.	.	.
cord-312386-88uwlmjx	155	1	We	-PRON-	PRP
cord-312386-88uwlmjx	155	2	recently	recently	RB
cord-312386-88uwlmjx	155	3	showed	show	VBD
cord-312386-88uwlmjx	155	4	that	that	IN
cord-312386-88uwlmjx	155	5	elevated	elevated	JJ
cord-312386-88uwlmjx	155	6	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	155	7	response	response	NN
cord-312386-88uwlmjx	155	8	in	in	IN
cord-312386-88uwlmjx	155	9	chickens	chicken	NNS
cord-312386-88uwlmjx	155	10	is	be	VBZ
cord-312386-88uwlmjx	155	11	a	a	DT
cord-312386-88uwlmjx	155	12	major	major	JJ
cord-312386-88uwlmjx	155	13	pathogenicity	pathogenicity	NN
cord-312386-88uwlmjx	155	14	factor	factor	NN
cord-312386-88uwlmjx	155	15	of	of	IN
cord-312386-88uwlmjx	155	16	HPAI	HPAI	NNP
cord-312386-88uwlmjx	155	17	-	-	HYPH
cord-312386-88uwlmjx	155	18	H5N1	H5N1	NNP
cord-312386-88uwlmjx	155	19	virus	virus	NN
cord-312386-88uwlmjx	155	20	infection	infection	NN
cord-312386-88uwlmjx	155	21	possibly	possibly	RB
cord-312386-88uwlmjx	155	22	mediated	mediate	VBN
cord-312386-88uwlmjx	155	23	by	by	IN
cord-312386-88uwlmjx	155	24	inhibition	inhibition	NN
cord-312386-88uwlmjx	155	25	of	of	IN
cord-312386-88uwlmjx	155	26	STAT3	STAT3	NNP
cord-312386-88uwlmjx	155	27	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	155	28	[	[	-LRB-
cord-312386-88uwlmjx	155	29	96	96	CD
cord-312386-88uwlmjx	155	30	]	]	-RRB-
cord-312386-88uwlmjx	155	31	.	.	.
cord-312386-88uwlmjx	156	1	HPAI	HPAI	NNP
cord-312386-88uwlmjx	156	2	-	-	HYPH
cord-312386-88uwlmjx	156	3	H5N1	H5N1	NNP
cord-312386-88uwlmjx	156	4	virus	virus	NN
cord-312386-88uwlmjx	156	5	infection	infection	NN
cord-312386-88uwlmjx	156	6	results	result	VBZ
cord-312386-88uwlmjx	156	7	in	in	IN
cord-312386-88uwlmjx	156	8	STAT3	STAT3	NNP
cord-312386-88uwlmjx	156	9	inhibition	inhibition	NN
cord-312386-88uwlmjx	156	10	and	and	CC
cord-312386-88uwlmjx	156	11	elevated	elevated	JJ
cord-312386-88uwlmjx	156	12	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	156	13	response	response	NN
cord-312386-88uwlmjx	156	14	in	in	IN
cord-312386-88uwlmjx	156	15	chicken	chicken	NN
cord-312386-88uwlmjx	156	16	cells	cell	NNS
cord-312386-88uwlmjx	156	17	.	.	.
cord-312386-88uwlmjx	157	1	In	in	IN
cord-312386-88uwlmjx	157	2	contrast	contrast	JJ
cord-312386-88uwlmjx	157	3	STAT3	stat3	CD
cord-312386-88uwlmjx	157	4	inhibition	inhibition	NN
cord-312386-88uwlmjx	157	5	was	be	VBD
cord-312386-88uwlmjx	157	6	not	not	RB
cord-312386-88uwlmjx	157	7	found	find	VBN
cord-312386-88uwlmjx	157	8	in	in	IN
cord-312386-88uwlmjx	157	9	HPAI	HPAI	NNP
cord-312386-88uwlmjx	157	10	-	-	HYPH
cord-312386-88uwlmjx	157	11	H5N1	H5N1	NNP
cord-312386-88uwlmjx	157	12	virus	virus	NN
cord-312386-88uwlmjx	157	13	infected	infect	VBN
cord-312386-88uwlmjx	157	14	duck	duck	NN
cord-312386-88uwlmjx	157	15	cells	cell	NNS
cord-312386-88uwlmjx	157	16	which	which	WDT
cord-312386-88uwlmjx	157	17	show	show	VBP
cord-312386-88uwlmjx	157	18	a	a	DT
cord-312386-88uwlmjx	157	19	moderate	moderate	JJ
cord-312386-88uwlmjx	157	20	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	157	21	response	response	NN
cord-312386-88uwlmjx	157	22	.	.	.
cord-312386-88uwlmjx	158	1	In	in	IN
cord-312386-88uwlmjx	158	2	summary	summary	NN
cord-312386-88uwlmjx	158	3	,	,	,
cord-312386-88uwlmjx	158	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	158	5	plays	play	VBZ
cord-312386-88uwlmjx	158	6	a	a	DT
cord-312386-88uwlmjx	158	7	significant	significant	JJ
cord-312386-88uwlmjx	158	8	role	role	NN
cord-312386-88uwlmjx	158	9	in	in	IN
cord-312386-88uwlmjx	158	10	the	the	DT
cord-312386-88uwlmjx	158	11	complex	complex	JJ
cord-312386-88uwlmjx	158	12	interplay	interplay	NN
cord-312386-88uwlmjx	158	13	between	between	IN
cord-312386-88uwlmjx	158	14	viruses	virus	NNS
cord-312386-88uwlmjx	158	15	and	and	CC
cord-312386-88uwlmjx	158	16	their	-PRON-	PRP$
cord-312386-88uwlmjx	158	17	hosts	host	NNS
cord-312386-88uwlmjx	158	18	and	and	CC
cord-312386-88uwlmjx	158	19	functions	function	NNS
cord-312386-88uwlmjx	158	20	as	as	IN
cord-312386-88uwlmjx	158	21	either	either	CC
cord-312386-88uwlmjx	158	22	a	a	DT
cord-312386-88uwlmjx	158	23	pro	pro	JJ
cord-312386-88uwlmjx	158	24	-	-	JJ
cord-312386-88uwlmjx	158	25	or	or	CC
cord-312386-88uwlmjx	158	26	antiviral	antiviral	JJ
cord-312386-88uwlmjx	158	27	factor	factor	NN
cord-312386-88uwlmjx	158	28	depending	depend	VBG
cord-312386-88uwlmjx	158	29	on	on	IN
cord-312386-88uwlmjx	158	30	the	the	DT
cord-312386-88uwlmjx	158	31	virus	virus	NN
cord-312386-88uwlmjx	158	32	and	and	CC
cord-312386-88uwlmjx	158	33	host	host	NN
cord-312386-88uwlmjx	158	34	cell	cell	NN
cord-312386-88uwlmjx	158	35	type	type	NN
cord-312386-88uwlmjx	158	36	involved	involve	VBN
cord-312386-88uwlmjx	158	37	.	.	.
cord-312386-88uwlmjx	159	1	While	while	IN
cord-312386-88uwlmjx	159	2	STAT3	STAT3	NNP
cord-312386-88uwlmjx	159	3	role	role	NN
cord-312386-88uwlmjx	159	4	has	have	VBZ
cord-312386-88uwlmjx	159	5	been	be	VBN
cord-312386-88uwlmjx	159	6	reasonably	reasonably	RB
cord-312386-88uwlmjx	159	7	well	well	RB
cord-312386-88uwlmjx	159	8	characterized	characterize	VBN
cord-312386-88uwlmjx	159	9	in	in	IN
cord-312386-88uwlmjx	159	10	the	the	DT
cord-312386-88uwlmjx	159	11	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	159	12	of	of	IN
cord-312386-88uwlmjx	159	13	oncogenic	oncogenic	JJ
cord-312386-88uwlmjx	159	14	viruses	virus	NNS
cord-312386-88uwlmjx	159	15	and	and	CC
cord-312386-88uwlmjx	159	16	viruses	virus	NNS
cord-312386-88uwlmjx	159	17	causing	cause	VBG
cord-312386-88uwlmjx	159	18	liver	liver	NN
cord-312386-88uwlmjx	159	19	pathology	pathology	NN
cord-312386-88uwlmjx	159	20	,	,	,
cord-312386-88uwlmjx	159	21	its	-PRON-	PRP$
cord-312386-88uwlmjx	159	22	role	role	NN
cord-312386-88uwlmjx	159	23	in	in	IN
cord-312386-88uwlmjx	159	24	many	many	JJ
cord-312386-88uwlmjx	159	25	other	other	JJ
cord-312386-88uwlmjx	159	26	viral	viral	JJ
cord-312386-88uwlmjx	159	27	infections	infection	NNS
cord-312386-88uwlmjx	159	28	is	be	VBZ
cord-312386-88uwlmjx	159	29	less	less	RBR
cord-312386-88uwlmjx	159	30	well	well	RB
cord-312386-88uwlmjx	159	31	understood	understand	VBN
cord-312386-88uwlmjx	159	32	.	.	.
cord-312386-88uwlmjx	160	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	160	2	regulates	regulate	VBZ
cord-312386-88uwlmjx	160	3	antiviral	antiviral	JJ
cord-312386-88uwlmjx	160	4	and	and	CC
cord-312386-88uwlmjx	160	5	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	160	6	responses	response	NNS
cord-312386-88uwlmjx	160	7	,	,	,
cord-312386-88uwlmjx	160	8	either	either	CC
cord-312386-88uwlmjx	160	9	through	through	IN
cord-312386-88uwlmjx	160	10	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	160	11	regulation	regulation	NN
cord-312386-88uwlmjx	160	12	of	of	IN
cord-312386-88uwlmjx	160	13	other	other	JJ
cord-312386-88uwlmjx	160	14	cellular	cellular	JJ
cord-312386-88uwlmjx	160	15	factors	factor	NNS
cord-312386-88uwlmjx	160	16	or	or	CC
cord-312386-88uwlmjx	160	17	through	through	IN
cord-312386-88uwlmjx	160	18	pathways	pathway	NNS
cord-312386-88uwlmjx	160	19	independent	independent	JJ
cord-312386-88uwlmjx	160	20	of	of	IN
cord-312386-88uwlmjx	160	21	its	-PRON-	PRP$
cord-312386-88uwlmjx	160	22	role	role	NN
cord-312386-88uwlmjx	160	23	as	as	IN
cord-312386-88uwlmjx	160	24	a	a	DT
cord-312386-88uwlmjx	160	25	transcription	transcription	NN
cord-312386-88uwlmjx	160	26	factor	factor	NN
cord-312386-88uwlmjx	160	27	.	.	.
cord-312386-88uwlmjx	161	1	The	the	DT
cord-312386-88uwlmjx	161	2	seemingly	seemingly	RB
cord-312386-88uwlmjx	161	3	contradictory	contradictory	JJ
cord-312386-88uwlmjx	161	4	roles	role	NNS
cord-312386-88uwlmjx	161	5	of	of	IN
cord-312386-88uwlmjx	161	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	161	7	in	in	IN
cord-312386-88uwlmjx	161	8	viral	viral	JJ
cord-312386-88uwlmjx	161	9	infections	infection	NNS
cord-312386-88uwlmjx	161	10	raise	raise	VBP
cord-312386-88uwlmjx	161	11	a	a	DT
cord-312386-88uwlmjx	161	12	number	number	NN
cord-312386-88uwlmjx	161	13	of	of	IN
cord-312386-88uwlmjx	161	14	interesting	interesting	JJ
cord-312386-88uwlmjx	161	15	questions	question	NNS
cord-312386-88uwlmjx	161	16	:	:	:
cord-312386-88uwlmjx	162	1	"	"	``
cord-312386-88uwlmjx	162	2	what	what	WDT
cord-312386-88uwlmjx	162	3	factors	factor	NNS
cord-312386-88uwlmjx	162	4	determine	determine	VBP
cord-312386-88uwlmjx	162	5	the	the	DT
cord-312386-88uwlmjx	162	6	switch	switch	NN
cord-312386-88uwlmjx	162	7	between	between	IN
cord-312386-88uwlmjx	162	8	pro	pro	JJ
cord-312386-88uwlmjx	162	9	-	-	JJ
cord-312386-88uwlmjx	162	10	and	and	CC
cord-312386-88uwlmjx	162	11	anti	anti	JJ
cord-312386-88uwlmjx	162	12	-	-	JJ
cord-312386-88uwlmjx	162	13	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	162	14	functions	function	NNS
cord-312386-88uwlmjx	162	15	of	of	IN
cord-312386-88uwlmjx	162	16	STAT3	STAT3	NNP
cord-312386-88uwlmjx	162	17	?	?	.
cord-312386-88uwlmjx	162	18	,	,	,
cord-312386-88uwlmjx	162	19	"	"	''
cord-312386-88uwlmjx	162	20	"	"	``
cord-312386-88uwlmjx	162	21	how	how	WRB
cord-312386-88uwlmjx	162	22	are	be	VBP
cord-312386-88uwlmjx	162	23	viruses	virus	NNS
cord-312386-88uwlmjx	162	24	able	able	JJ
cord-312386-88uwlmjx	162	25	to	to	TO
cord-312386-88uwlmjx	162	26	exploit	exploit	VB
cord-312386-88uwlmjx	162	27	STAT3	STAT3	NNP
cord-312386-88uwlmjx	162	28	signalling	signal	VBG
cord-312386-88uwlmjx	162	29	for	for	IN
cord-312386-88uwlmjx	162	30	their	-PRON-	PRP$
cord-312386-88uwlmjx	162	31	gene	gene	NN
cord-312386-88uwlmjx	162	32	replication	replication	NN
cord-312386-88uwlmjx	162	33	?	?	.
cord-312386-88uwlmjx	162	34	,	,	,
cord-312386-88uwlmjx	162	35	"	"	''
cord-312386-88uwlmjx	162	36	and	and	CC
cord-312386-88uwlmjx	162	37	"	"	``
cord-312386-88uwlmjx	162	38	does	do	VBZ
cord-312386-88uwlmjx	162	39	STAT3	stat3	XX
cord-312386-88uwlmjx	163	1	either	either	CC
cord-312386-88uwlmjx	163	2	negatively	negatively	RB
cord-312386-88uwlmjx	163	3	or	or	CC
cord-312386-88uwlmjx	163	4	positively	positively	RB
cord-312386-88uwlmjx	163	5	regulate	regulate	VB
cord-312386-88uwlmjx	163	6	type	type	NN
cord-312386-88uwlmjx	163	7	1	1	CD
cord-312386-88uwlmjx	163	8	IFN	IFN	NNP
cord-312386-88uwlmjx	163	9	response	response	NN
cord-312386-88uwlmjx	163	10	depending	depend	VBG
cord-312386-88uwlmjx	163	11	on	on	IN
cord-312386-88uwlmjx	163	12	the	the	DT
cord-312386-88uwlmjx	163	13	virus	virus	NN
cord-312386-88uwlmjx	163	14	type	type	NN
cord-312386-88uwlmjx	163	15	involved	involve	VBN
cord-312386-88uwlmjx	163	16	?	?	.
cord-312386-88uwlmjx	163	17	"	"	''
cord-312386-88uwlmjx	164	1	Further	further	RB
cord-312386-88uwlmjx	164	2	in	in	IN
cord-312386-88uwlmjx	164	3	depth	depth	NN
cord-312386-88uwlmjx	164	4	studies	study	NNS
cord-312386-88uwlmjx	164	5	to	to	TO
cord-312386-88uwlmjx	164	6	dissect	dissect	VB
cord-312386-88uwlmjx	164	7	the	the	DT
cord-312386-88uwlmjx	164	8	role	role	NN
cord-312386-88uwlmjx	164	9	of	of	IN
cord-312386-88uwlmjx	164	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	164	11	in	in	IN
cord-312386-88uwlmjx	164	12	viral	viral	JJ
cord-312386-88uwlmjx	164	13	infections	infection	NNS
cord-312386-88uwlmjx	164	14	could	could	MD
cord-312386-88uwlmjx	164	15	provide	provide	VB
cord-312386-88uwlmjx	164	16	valuable	valuable	JJ
cord-312386-88uwlmjx	164	17	insights	insight	NNS
cord-312386-88uwlmjx	164	18	into	into	IN
cord-312386-88uwlmjx	164	19	viral	viral	JJ
cord-312386-88uwlmjx	164	20	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	164	21	and	and	CC
cord-312386-88uwlmjx	164	22	development	development	NN
cord-312386-88uwlmjx	164	23	of	of	IN
cord-312386-88uwlmjx	164	24	novel	novel	JJ
cord-312386-88uwlmjx	164	25	antiviral	antiviral	JJ
cord-312386-88uwlmjx	164	26	therapies	therapy	NNS
cord-312386-88uwlmjx	164	27	.	.	.
cord-312386-88uwlmjx	165	1	In	in	IN
cord-312386-88uwlmjx	165	2	vitro	vitro	FW
cord-312386-88uwlmjx	165	3	studies	study	NNS
cord-312386-88uwlmjx	165	4	using	use	VBG
cord-312386-88uwlmjx	165	5	cell	cell	NN
cord-312386-88uwlmjx	165	6	culture	culture	NN
cord-312386-88uwlmjx	165	7	systems	system	NNS
cord-312386-88uwlmjx	165	8	are	be	VBP
cord-312386-88uwlmjx	165	9	a	a	DT
cord-312386-88uwlmjx	165	10	valuable	valuable	JJ
cord-312386-88uwlmjx	165	11	tool	tool	NN
cord-312386-88uwlmjx	165	12	to	to	TO
cord-312386-88uwlmjx	165	13	dissect	dissect	VB
cord-312386-88uwlmjx	165	14	the	the	DT
cord-312386-88uwlmjx	165	15	molecular	molecular	JJ
cord-312386-88uwlmjx	165	16	basis	basis	NN
cord-312386-88uwlmjx	165	17	of	of	IN
cord-312386-88uwlmjx	165	18	STAT3	STAT3	NNP
cord-312386-88uwlmjx	165	19	role	role	NN
cord-312386-88uwlmjx	165	20	in	in	IN
cord-312386-88uwlmjx	165	21	innate	innate	JJ
cord-312386-88uwlmjx	165	22	response	response	NN
cord-312386-88uwlmjx	165	23	to	to	IN
cord-312386-88uwlmjx	165	24	viruses	virus	NNS
cord-312386-88uwlmjx	165	25	.	.	.
cord-312386-88uwlmjx	166	1	However	however	RB
cord-312386-88uwlmjx	166	2	,	,	,
cord-312386-88uwlmjx	166	3	in	in	IN
cord-312386-88uwlmjx	166	4	vivo	vivo	NN
cord-312386-88uwlmjx	166	5	studies	study	NNS
cord-312386-88uwlmjx	166	6	are	be	VBP
cord-312386-88uwlmjx	166	7	essential	essential	JJ
cord-312386-88uwlmjx	166	8	to	to	TO
cord-312386-88uwlmjx	166	9	elucidate	elucidate	VB
cord-312386-88uwlmjx	166	10	STAT3	STAT3	NNP
cord-312386-88uwlmjx	166	11	role	role	NN
cord-312386-88uwlmjx	166	12	in	in	IN
cord-312386-88uwlmjx	166	13	adaptive	adaptive	JJ
cord-312386-88uwlmjx	166	14	immune	immune	JJ
cord-312386-88uwlmjx	166	15	response	response	NN
cord-312386-88uwlmjx	166	16	to	to	IN
cord-312386-88uwlmjx	166	17	viruses	virus	NNS
cord-312386-88uwlmjx	166	18	.	.	.
cord-312386-88uwlmjx	167	1	Complementary	complementary	JJ
cord-312386-88uwlmjx	167	2	in	in	IN
cord-312386-88uwlmjx	167	3	vitro	vitro	FW
cord-312386-88uwlmjx	167	4	and	and	CC
cord-312386-88uwlmjx	167	5	in	in	IN
cord-312386-88uwlmjx	167	6	vivo	vivo	NN
cord-312386-88uwlmjx	167	7	experiments	experiment	NNS
cord-312386-88uwlmjx	167	8	are	be	VBP
cord-312386-88uwlmjx	167	9	therefore	therefore	RB
cord-312386-88uwlmjx	167	10	essential	essential	JJ
cord-312386-88uwlmjx	167	11	to	to	TO
cord-312386-88uwlmjx	167	12	better	better	RB
cord-312386-88uwlmjx	167	13	understand	understand	VB
cord-312386-88uwlmjx	167	14	the	the	DT
cord-312386-88uwlmjx	167	15	seemingly	seemingly	RB
cord-312386-88uwlmjx	167	16	contradictory	contradictory	JJ
cord-312386-88uwlmjx	167	17	role	role	NN
cord-312386-88uwlmjx	167	18	of	of	IN
cord-312386-88uwlmjx	167	19	STAT3	STAT3	NNP
cord-312386-88uwlmjx	167	20	in	in	IN
cord-312386-88uwlmjx	167	21	viral	viral	JJ
cord-312386-88uwlmjx	167	22	infections	infection	NNS
cord-312386-88uwlmjx	167	23	.	.	.
cord-312386-88uwlmjx	168	1	The	the	DT
cord-312386-88uwlmjx	168	2	author	author	NN
cord-312386-88uwlmjx	168	3	declares	declare	VBZ
cord-312386-88uwlmjx	168	4	that	that	IN
cord-312386-88uwlmjx	168	5	there	there	EX
cord-312386-88uwlmjx	168	6	is	be	VBZ
cord-312386-88uwlmjx	168	7	no	no	DT
cord-312386-88uwlmjx	168	8	conflict	conflict	NN
cord-312386-88uwlmjx	168	9	of	of	IN
cord-312386-88uwlmjx	168	10	interests	interest	NNS
cord-312386-88uwlmjx	168	11	regarding	regard	VBG
cord-312386-88uwlmjx	168	12	the	the	DT
cord-312386-88uwlmjx	168	13	publication	publication	NN
cord-312386-88uwlmjx	168	14	of	of	IN
cord-312386-88uwlmjx	168	15	this	this	DT
cord-312386-88uwlmjx	168	16	paper	paper	NN
cord-312386-88uwlmjx	168	17	.	.	.
cord-312386-88uwlmjx	169	1	STAT	stat	NN
cord-312386-88uwlmjx	169	2	signaling	signal	VBG
cord-312386-88uwlmjx	169	3	is	be	VBZ
cord-312386-88uwlmjx	169	4	active	active	JJ
cord-312386-88uwlmjx	169	5	during	during	IN
cord-312386-88uwlmjx	169	6	early	early	JJ
cord-312386-88uwlmjx	169	7	mammalian	mammalian	JJ
cord-312386-88uwlmjx	169	8	development	development	NN
cord-312386-88uwlmjx	169	9	STAT3	STAT3	NNP
cord-312386-88uwlmjx	169	10	signaling	signal	VBG
cord-312386-88uwlmjx	169	11	:	:	:
cord-312386-88uwlmjx	169	12	anticancer	anticancer	JJ
cord-312386-88uwlmjx	169	13	strategies	strategy	NNS
cord-312386-88uwlmjx	169	14	and	and	CC
cord-312386-88uwlmjx	169	15	challenges	challenge	VBZ
cord-312386-88uwlmjx	169	16	Jak	Jak	NNP
cord-312386-88uwlmjx	169	17	-	-	HYPH
cord-312386-88uwlmjx	169	18	STAT	stat	NN
cord-312386-88uwlmjx	169	19	pathways	pathway	NNS
cord-312386-88uwlmjx	169	20	and	and	CC
cord-312386-88uwlmjx	169	21	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	169	22	activation	activation	NN
cord-312386-88uwlmjx	169	23	in	in	IN
cord-312386-88uwlmjx	169	24	response	response	NN
cord-312386-88uwlmjx	169	25	to	to	IN
cord-312386-88uwlmjx	169	26	IFNs	ifn	NNS
cord-312386-88uwlmjx	169	27	and	and	CC
cord-312386-88uwlmjx	169	28	other	other	JJ
cord-312386-88uwlmjx	169	29	extracellular	extracellular	JJ
cord-312386-88uwlmjx	169	30	signaling	signal	VBG
cord-312386-88uwlmjx	169	31	proteins	protein	NNS
cord-312386-88uwlmjx	169	32	Interleukin-6-type	interleukin-6-type	IN
cord-312386-88uwlmjx	169	33	cytokine	cytokine	NN
cord-312386-88uwlmjx	169	34	signalling	signal	VBG
cord-312386-88uwlmjx	169	35	through	through	IN
cord-312386-88uwlmjx	169	36	the	the	DT
cord-312386-88uwlmjx	169	37	gp130	gp130	NNS
cord-312386-88uwlmjx	169	38	/	/	SYM
cord-312386-88uwlmjx	169	39	Jak	Jak	NNP
cord-312386-88uwlmjx	169	40	/	/	SYM
cord-312386-88uwlmjx	169	41	STAT	stat	NN
cord-312386-88uwlmjx	169	42	pathway	pathway	NN
cord-312386-88uwlmjx	169	43	How	how	WRB
cord-312386-88uwlmjx	169	44	cells	cell	NNS
cord-312386-88uwlmjx	169	45	respond	respond	VBP
cord-312386-88uwlmjx	169	46	to	to	IN
cord-312386-88uwlmjx	169	47	interferons	interferon	NNS
cord-312386-88uwlmjx	170	1	Stat3	Stat3	NNP
cord-312386-88uwlmjx	170	2	:	:	:
cord-312386-88uwlmjx	171	1	a	a	DT
cord-312386-88uwlmjx	171	2	STAT	stat	NN
cord-312386-88uwlmjx	171	3	family	family	NN
cord-312386-88uwlmjx	171	4	member	member	NN
cord-312386-88uwlmjx	171	5	activated	activate	VBN
cord-312386-88uwlmjx	171	6	by	by	IN
cord-312386-88uwlmjx	171	7	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	171	8	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	171	9	in	in	IN
cord-312386-88uwlmjx	171	10	response	response	NN
cord-312386-88uwlmjx	171	11	to	to	IN
cord-312386-88uwlmjx	171	12	epidermal	epidermal	JJ
cord-312386-88uwlmjx	171	13	growth	growth	NN
cord-312386-88uwlmjx	171	14	factor	factor	NN
cord-312386-88uwlmjx	171	15	and	and	CC
cord-312386-88uwlmjx	171	16	interleukin-6	interleukin-6	NNP
cord-312386-88uwlmjx	171	17	Molecular	molecular	JJ
cord-312386-88uwlmjx	171	18	cloning	cloning	NN
cord-312386-88uwlmjx	171	19	of	of	IN
cord-312386-88uwlmjx	171	20	APRF	APRF	NNP
cord-312386-88uwlmjx	171	21	,	,	,
cord-312386-88uwlmjx	171	22	a	a	DT
cord-312386-88uwlmjx	171	23	novel	novel	NN
cord-312386-88uwlmjx	171	24	IFN	IFN	NNP
cord-312386-88uwlmjx	171	25	-	-	HYPH
cord-312386-88uwlmjx	171	26	stimulated	stimulate	VBN
cord-312386-88uwlmjx	171	27	gene	gene	NN
cord-312386-88uwlmjx	171	28	factor	factor	NN
cord-312386-88uwlmjx	171	29	3	3	CD
cord-312386-88uwlmjx	171	30	p91-related	p91-related	NN
cord-312386-88uwlmjx	171	31	transcription	transcription	NN
cord-312386-88uwlmjx	171	32	factor	factor	NN
cord-312386-88uwlmjx	171	33	involved	involve	VBN
cord-312386-88uwlmjx	171	34	in	in	IN
cord-312386-88uwlmjx	171	35	the	the	DT
cord-312386-88uwlmjx	171	36	gp130-mediated	gp130-mediate	VBN
cord-312386-88uwlmjx	171	37	signaling	signal	VBG
cord-312386-88uwlmjx	171	38	pathway	pathway	NN
cord-312386-88uwlmjx	171	39	JAK	JAK	NNP
cord-312386-88uwlmjx	171	40	-	-	HYPH
cord-312386-88uwlmjx	171	41	STAT	STAT	NNP
cord-312386-88uwlmjx	171	42	signaling	signaling	NN
cord-312386-88uwlmjx	171	43	:	:	:
cord-312386-88uwlmjx	171	44	from	from	IN
cord-312386-88uwlmjx	171	45	interferons	interferon	NNS
cord-312386-88uwlmjx	171	46	to	to	IN
cord-312386-88uwlmjx	171	47	cytokines	cytokine	NNS
cord-312386-88uwlmjx	171	48	STATs	stat	NNS
cord-312386-88uwlmjx	171	49	in	in	IN
cord-312386-88uwlmjx	171	50	cancer	cancer	NN
cord-312386-88uwlmjx	171	51	inflammation	inflammation	NN
cord-312386-88uwlmjx	171	52	and	and	CC
cord-312386-88uwlmjx	171	53	immunity	immunity	NN
cord-312386-88uwlmjx	171	54	:	:	:
cord-312386-88uwlmjx	171	55	a	a	DT
cord-312386-88uwlmjx	171	56	leading	lead	VBG
cord-312386-88uwlmjx	171	57	role	role	NN
cord-312386-88uwlmjx	171	58	for	for	IN
cord-312386-88uwlmjx	171	59	STAT3	STAT3	NNP
cord-312386-88uwlmjx	172	1	STATs	stat	NNS
cord-312386-88uwlmjx	172	2	:	:	:
cord-312386-88uwlmjx	173	1	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	173	2	control	control	NN
cord-312386-88uwlmjx	173	3	and	and	CC
cord-312386-88uwlmjx	173	4	biological	biological	JJ
cord-312386-88uwlmjx	173	5	impact	impact	NN
cord-312386-88uwlmjx	173	6	Dynamics	dynamic	NNS
cord-312386-88uwlmjx	173	7	and	and	CC
cord-312386-88uwlmjx	173	8	noncanonical	noncanonical	JJ
cord-312386-88uwlmjx	173	9	aspects	aspect	NNS
cord-312386-88uwlmjx	173	10	of	of	IN
cord-312386-88uwlmjx	173	11	JAK	JAK	NNP
cord-312386-88uwlmjx	173	12	/	/	SYM
cord-312386-88uwlmjx	173	13	STAT	STAT	NNP
cord-312386-88uwlmjx	173	14	signalling	signal	VBG
cord-312386-88uwlmjx	173	15	Canonical	canonical	JJ
cord-312386-88uwlmjx	173	16	and	and	CC
cord-312386-88uwlmjx	173	17	non	non	JJ
cord-312386-88uwlmjx	173	18	-	-	JJ
cord-312386-88uwlmjx	173	19	canonical	canonical	JJ
cord-312386-88uwlmjx	173	20	JAK	JAK	NNP
cord-312386-88uwlmjx	173	21	-	-	HYPH
cord-312386-88uwlmjx	173	22	STAT	STAT	NNP
cord-312386-88uwlmjx	174	1	signaling	signal	VBG
cord-312386-88uwlmjx	174	2	What	what	WP
cord-312386-88uwlmjx	174	3	does	do	VBZ
cord-312386-88uwlmjx	174	4	Stat3	Stat3	NNP
cord-312386-88uwlmjx	174	5	do	do	VB
cord-312386-88uwlmjx	174	6	?	?	.
cord-312386-88uwlmjx	175	1	Targeted	target	VBN
cord-312386-88uwlmjx	175	2	disruption	disruption	NN
cord-312386-88uwlmjx	175	3	of	of	IN
cord-312386-88uwlmjx	175	4	the	the	DT
cord-312386-88uwlmjx	175	5	mouse	mouse	NN
cord-312386-88uwlmjx	175	6	Stat3	Stat3	NNP
cord-312386-88uwlmjx	175	7	gene	gene	NN
cord-312386-88uwlmjx	175	8	leads	lead	VBZ
cord-312386-88uwlmjx	175	9	to	to	IN
cord-312386-88uwlmjx	175	10	early	early	JJ
cord-312386-88uwlmjx	175	11	embryonic	embryonic	JJ
cord-312386-88uwlmjx	175	12	lethality	lethality	NN
cord-312386-88uwlmjx	175	13	Potential	potential	JJ
cord-312386-88uwlmjx	175	14	role	role	NN
cord-312386-88uwlmjx	175	15	of	of	IN
cord-312386-88uwlmjx	175	16	signal	signal	NN
cord-312386-88uwlmjx	175	17	transducer	transducer	NN
cord-312386-88uwlmjx	175	18	and	and	CC
cord-312386-88uwlmjx	175	19	activator	activator	NN
cord-312386-88uwlmjx	175	20	of	of	IN
cord-312386-88uwlmjx	175	21	transcription	transcription	NN
cord-312386-88uwlmjx	176	1	(	(	-LRB-
cord-312386-88uwlmjx	176	2	STAT)3	STAT)3	NNP
cord-312386-88uwlmjx	176	3	signaling	signal	VBG
cord-312386-88uwlmjx	176	4	pathway	pathway	NN
cord-312386-88uwlmjx	176	5	in	in	IN
cord-312386-88uwlmjx	176	6	inflammation	inflammation	NN
cord-312386-88uwlmjx	176	7	,	,	,
cord-312386-88uwlmjx	176	8	survival	survival	NN
cord-312386-88uwlmjx	176	9	,	,	,
cord-312386-88uwlmjx	176	10	proliferation	proliferation	NN
cord-312386-88uwlmjx	176	11	and	and	CC
cord-312386-88uwlmjx	176	12	invasion	invasion	NN
cord-312386-88uwlmjx	176	13	of	of	IN
cord-312386-88uwlmjx	176	14	hepatocellular	hepatocellular	JJ
cord-312386-88uwlmjx	176	15	carcinoma	carcinoma	NN
cord-312386-88uwlmjx	176	16	Targeting	target	VBG
cord-312386-88uwlmjx	176	17	the	the	DT
cord-312386-88uwlmjx	176	18	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	19	signaling	signal	VBG
cord-312386-88uwlmjx	176	20	pathway	pathway	NN
cord-312386-88uwlmjx	176	21	in	in	IN
cord-312386-88uwlmjx	176	22	cancer	cancer	NN
cord-312386-88uwlmjx	176	23	:	:	:
cord-312386-88uwlmjx	176	24	role	role	NN
cord-312386-88uwlmjx	176	25	of	of	IN
cord-312386-88uwlmjx	176	26	synthetic	synthetic	JJ
cord-312386-88uwlmjx	176	27	and	and	CC
cord-312386-88uwlmjx	176	28	natural	natural	JJ
cord-312386-88uwlmjx	176	29	inhibitors	inhibitor	NNS
cord-312386-88uwlmjx	176	30	Leukemia	Leukemia	NNP
cord-312386-88uwlmjx	176	31	inhibitory	inhibitory	JJ
cord-312386-88uwlmjx	176	32	factor	factor	NN
cord-312386-88uwlmjx	176	33	-	-	HYPH
cord-312386-88uwlmjx	176	34	dependent	dependent	JJ
cord-312386-88uwlmjx	176	35	transcriptional	transcriptional	JJ
cord-312386-88uwlmjx	176	36	activation	activation	NN
cord-312386-88uwlmjx	176	37	in	in	IN
cord-312386-88uwlmjx	176	38	embryonic	embryonic	JJ
cord-312386-88uwlmjx	176	39	stem	stem	NN
cord-312386-88uwlmjx	176	40	cells	cell	NNS
cord-312386-88uwlmjx	176	41	Self	self	NN
cord-312386-88uwlmjx	176	42	-	-	HYPH
cord-312386-88uwlmjx	176	43	renewal	renewal	NN
cord-312386-88uwlmjx	176	44	of	of	IN
cord-312386-88uwlmjx	176	45	pluripotent	pluripotent	JJ
cord-312386-88uwlmjx	176	46	embryonic	embryonic	JJ
cord-312386-88uwlmjx	176	47	stem	stem	NN
cord-312386-88uwlmjx	176	48	cells	cell	NNS
cord-312386-88uwlmjx	176	49	is	be	VBZ
cord-312386-88uwlmjx	176	50	mediated	mediate	VBN
cord-312386-88uwlmjx	176	51	via	via	IN
cord-312386-88uwlmjx	176	52	activation	activation	NN
cord-312386-88uwlmjx	176	53	of	of	IN
cord-312386-88uwlmjx	176	54	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	55	Essential	essential	JJ
cord-312386-88uwlmjx	176	56	role	role	NN
cord-312386-88uwlmjx	176	57	of	of	IN
cord-312386-88uwlmjx	176	58	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	59	for	for	IN
cord-312386-88uwlmjx	176	60	embryonic	embryonic	JJ
cord-312386-88uwlmjx	176	61	stem	stem	NN
cord-312386-88uwlmjx	176	62	cell	cell	NN
cord-312386-88uwlmjx	176	63	pluripotency	pluripotency	NN
cord-312386-88uwlmjx	176	64	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	65	activation	activation	NN
cord-312386-88uwlmjx	176	66	is	be	VBZ
cord-312386-88uwlmjx	176	67	sufficient	sufficient	JJ
cord-312386-88uwlmjx	176	68	to	to	TO
cord-312386-88uwlmjx	176	69	maintain	maintain	VB
cord-312386-88uwlmjx	176	70	an	an	DT
cord-312386-88uwlmjx	176	71	undifferentiated	undifferentiated	JJ
cord-312386-88uwlmjx	176	72	state	state	NN
cord-312386-88uwlmjx	176	73	of	of	IN
cord-312386-88uwlmjx	176	74	mouse	mouse	NN
cord-312386-88uwlmjx	176	75	embryonic	embryonic	JJ
cord-312386-88uwlmjx	176	76	stem	stem	NN
cord-312386-88uwlmjx	176	77	cells	cell	NNS
cord-312386-88uwlmjx	176	78	Roles	role	NNS
cord-312386-88uwlmjx	176	79	of	of	IN
cord-312386-88uwlmjx	176	80	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	81	in	in	IN
cord-312386-88uwlmjx	176	82	mediating	mediate	VBG
cord-312386-88uwlmjx	176	83	the	the	DT
cord-312386-88uwlmjx	176	84	cell	cell	NN
cord-312386-88uwlmjx	176	85	growth	growth	NN
cord-312386-88uwlmjx	176	86	,	,	,
cord-312386-88uwlmjx	176	87	differentiation	differentiation	NN
cord-312386-88uwlmjx	176	88	and	and	CC
cord-312386-88uwlmjx	176	89	survival	survival	NN
cord-312386-88uwlmjx	176	90	signals	signal	NNS
cord-312386-88uwlmjx	176	91	relayed	relay	VBN
cord-312386-88uwlmjx	176	92	through	through	IN
cord-312386-88uwlmjx	176	93	the	the	DT
cord-312386-88uwlmjx	176	94	IL-6	IL-6	NNP
cord-312386-88uwlmjx	176	95	family	family	NN
cord-312386-88uwlmjx	176	96	of	of	IN
cord-312386-88uwlmjx	176	97	cytokine	cytokine	NN
cord-312386-88uwlmjx	176	98	receptors	receptor	NNS
cord-312386-88uwlmjx	176	99	Crystal	Crystal	NNP
cord-312386-88uwlmjx	176	100	structure	structure	NN
cord-312386-88uwlmjx	176	101	of	of	IN
cord-312386-88uwlmjx	176	102	unphosphorylated	unphosphorylated	NNP
cord-312386-88uwlmjx	176	103	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	104	core	core	NN
cord-312386-88uwlmjx	176	105	fragment	fragment	NN
cord-312386-88uwlmjx	176	106	Ciliary	Ciliary	NNP
cord-312386-88uwlmjx	176	107	neurotrophic	neurotrophic	JJ
cord-312386-88uwlmjx	176	108	factor	factor	NN
cord-312386-88uwlmjx	176	109	and	and	CC
cord-312386-88uwlmjx	176	110	stress	stress	NN
cord-312386-88uwlmjx	176	111	stimuli	stimulus	NNS
cord-312386-88uwlmjx	176	112	activate	activate	VBP
cord-312386-88uwlmjx	176	113	the	the	DT
cord-312386-88uwlmjx	176	114	Jak	Jak	NNP
cord-312386-88uwlmjx	176	115	-	-	HYPH
cord-312386-88uwlmjx	176	116	STAT	STAT	NNP
cord-312386-88uwlmjx	176	117	pathway	pathway	NN
cord-312386-88uwlmjx	176	118	in	in	IN
cord-312386-88uwlmjx	176	119	retinal	retinal	JJ
cord-312386-88uwlmjx	176	120	neurons	neuron	NNS
cord-312386-88uwlmjx	176	121	and	and	CC
cord-312386-88uwlmjx	176	122	glia	glia	NNP
cord-312386-88uwlmjx	176	123	IL-5	IL-5	NNP
cord-312386-88uwlmjx	176	124	and	and	CC
cord-312386-88uwlmjx	176	125	granulocyte	granulocyte	NN
cord-312386-88uwlmjx	176	126	-	-	HYPH
cord-312386-88uwlmjx	176	127	macrophage	macrophage	NN
cord-312386-88uwlmjx	176	128	colony	colony	NN
cord-312386-88uwlmjx	176	129	-	-	HYPH
cord-312386-88uwlmjx	176	130	stimulating	stimulate	VBG
cord-312386-88uwlmjx	176	131	factor	factor	NN
cord-312386-88uwlmjx	176	132	activate	activate	VBP
cord-312386-88uwlmjx	176	133	STAT3	STAT3	NNP
cord-312386-88uwlmjx	176	134	and	and	CC
cord-312386-88uwlmjx	176	135	STAT5	stat5	NN
cord-312386-88uwlmjx	176	136	and	and	CC
cord-312386-88uwlmjx	176	137	promote	promote	VB
cord-312386-88uwlmjx	176	138	Pim-1	Pim-1	NNP
cord-312386-88uwlmjx	176	139	and	and	CC
cord-312386-88uwlmjx	176	140	cyclin	cyclin	NN
cord-312386-88uwlmjx	176	141	D3	D3	NNP
cord-312386-88uwlmjx	176	142	protein	protein	NN
cord-312386-88uwlmjx	176	143	expression	expression	NN
cord-312386-88uwlmjx	176	144	in	in	IN
cord-312386-88uwlmjx	176	145	human	human	JJ
cord-312386-88uwlmjx	176	146	eosinophils	eosinophil	NNS
cord-312386-88uwlmjx	177	1	IL-9	IL-9	NNP
cord-312386-88uwlmjx	177	2	Induces	induce	VBZ
cord-312386-88uwlmjx	177	3	CCL11	CCL11	NNP
cord-312386-88uwlmjx	177	4	expression	expression	NN
cord-312386-88uwlmjx	177	5	via	via	IN
cord-312386-88uwlmjx	177	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	177	7	signalling	signal	VBG
cord-312386-88uwlmjx	177	8	in	in	IN
cord-312386-88uwlmjx	177	9	human	human	JJ
cord-312386-88uwlmjx	177	10	airway	airway	NN
cord-312386-88uwlmjx	177	11	smooth	smooth	JJ
cord-312386-88uwlmjx	177	12	muscle	muscle	NN
cord-312386-88uwlmjx	177	13	cells	cell	NNS
cord-312386-88uwlmjx	177	14	Activation	activation	NN
cord-312386-88uwlmjx	177	15	of	of	IN
cord-312386-88uwlmjx	177	16	STAT3	STAT3	NNP
cord-312386-88uwlmjx	178	1	by	by	IN
cord-312386-88uwlmjx	178	2	IL-6	IL-6	NNP
cord-312386-88uwlmjx	178	3	and	and	CC
cord-312386-88uwlmjx	178	4	IL-10	IL-10	NNP
cord-312386-88uwlmjx	178	5	in	in	IN
cord-312386-88uwlmjx	178	6	primary	primary	JJ
cord-312386-88uwlmjx	178	7	human	human	JJ
cord-312386-88uwlmjx	178	8	macrophages	macrophage	NNS
cord-312386-88uwlmjx	178	9	is	be	VBZ
cord-312386-88uwlmjx	178	10	differentially	differentially	RB
cord-312386-88uwlmjx	178	11	modulated	modulate	VBN
cord-312386-88uwlmjx	178	12	by	by	IN
cord-312386-88uwlmjx	178	13	suppressor	suppressor	NN
cord-312386-88uwlmjx	178	14	of	of	IN
cord-312386-88uwlmjx	178	15	cytokine	cytokine	NN
cord-312386-88uwlmjx	178	16	signaling	signaling	NN
cord-312386-88uwlmjx	179	1	3	3	LS
cord-312386-88uwlmjx	179	2	STAT3	STAT3	NNP
cord-312386-88uwlmjx	179	3	and	and	CC
cord-312386-88uwlmjx	179	4	STAT1	stat1	VB
cord-312386-88uwlmjx	179	5	mediate	mediate	VB
cord-312386-88uwlmjx	179	6	IL-11-dependent	il-11-dependent	NN
cord-312386-88uwlmjx	179	7	and	and	CC
cord-312386-88uwlmjx	179	8	inflammation	inflammation	NN
cord-312386-88uwlmjx	179	9	-	-	HYPH
cord-312386-88uwlmjx	179	10	associated	associate	VBN
cord-312386-88uwlmjx	179	11	gastric	gastric	JJ
cord-312386-88uwlmjx	179	12	tumorigenesis	tumorigenesis	NN
cord-312386-88uwlmjx	179	13	in	in	IN
cord-312386-88uwlmjx	179	14	gp130	gp130	NNP
cord-312386-88uwlmjx	179	15	receptor	receptor	NN
cord-312386-88uwlmjx	179	16	mutant	mutant	JJ
cord-312386-88uwlmjx	179	17	mice	mouse	NNS
cord-312386-88uwlmjx	180	1	Interleukin	interleukin	NN
cord-312386-88uwlmjx	180	2	12	12	CD
cord-312386-88uwlmjx	180	3	signaling	signal	VBG
cord-312386-88uwlmjx	180	4	in	in	IN
cord-312386-88uwlmjx	180	5	T	T	NNP
cord-312386-88uwlmjx	180	6	helper	helper	NN
cord-312386-88uwlmjx	180	7	type	type	NN
cord-312386-88uwlmjx	180	8	1	1	CD
cord-312386-88uwlmjx	180	9	(	(	-LRB-
cord-312386-88uwlmjx	180	10	Th1	Th1	NNP
cord-312386-88uwlmjx	180	11	)	)	-RRB-
cord-312386-88uwlmjx	180	12	cells	cell	NNS
cord-312386-88uwlmjx	180	13	involves	involve	VBZ
cord-312386-88uwlmjx	180	14	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	180	15	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	180	16	of	of	IN
cord-312386-88uwlmjx	180	17	signal	signal	NN
cord-312386-88uwlmjx	180	18	transducer	transducer	NN
cord-312386-88uwlmjx	180	19	and	and	CC
cord-312386-88uwlmjx	180	20	activator	activator	NN
cord-312386-88uwlmjx	180	21	of	of	IN
cord-312386-88uwlmjx	180	22	transcription	transcription	NN
cord-312386-88uwlmjx	180	23	(	(	-LRB-
cord-312386-88uwlmjx	180	24	Stat)3	Stat)3	NNP
cord-312386-88uwlmjx	180	25	and	and	CC
cord-312386-88uwlmjx	180	26	Stat4	Stat4	NNP
cord-312386-88uwlmjx	180	27	IL-21	IL-21	NNP
cord-312386-88uwlmjx	180	28	contributes	contribute	VBZ
cord-312386-88uwlmjx	180	29	to	to	IN
cord-312386-88uwlmjx	180	30	JAK3	JAK3	NNP
cord-312386-88uwlmjx	180	31	/	/	SYM
cord-312386-88uwlmjx	180	32	STAT3	stat3	CD
cord-312386-88uwlmjx	180	33	activation	activation	NN
cord-312386-88uwlmjx	180	34	and	and	CC
cord-312386-88uwlmjx	180	35	promotes	promote	VBZ
cord-312386-88uwlmjx	180	36	cell	cell	NN
cord-312386-88uwlmjx	180	37	growth	growth	NN
cord-312386-88uwlmjx	180	38	in	in	IN
cord-312386-88uwlmjx	180	39	ALKpositive	ALKpositive	NNP
cord-312386-88uwlmjx	180	40	anaplastic	anaplastic	JJ
cord-312386-88uwlmjx	180	41	large	large	JJ
cord-312386-88uwlmjx	180	42	cell	cell	NN
cord-312386-88uwlmjx	180	43	lymphoma	lymphoma	NN
cord-312386-88uwlmjx	180	44	IL-22	IL-22	NNP
cord-312386-88uwlmjx	180	45	is	be	VBZ
cord-312386-88uwlmjx	180	46	related	relate	VBN
cord-312386-88uwlmjx	180	47	to	to	IN
cord-312386-88uwlmjx	180	48	development	development	NN
cord-312386-88uwlmjx	180	49	of	of	IN
cord-312386-88uwlmjx	180	50	human	human	JJ
cord-312386-88uwlmjx	180	51	colon	colon	NN
cord-312386-88uwlmjx	180	52	cancer	cancer	NN
cord-312386-88uwlmjx	180	53	by	by	IN
cord-312386-88uwlmjx	180	54	activation	activation	NN
cord-312386-88uwlmjx	180	55	of	of	IN
cord-312386-88uwlmjx	180	56	STAT3	STAT3	NNP
cord-312386-88uwlmjx	181	1	A	a	DT
cord-312386-88uwlmjx	181	2	novel	novel	JJ
cord-312386-88uwlmjx	181	3	role	role	NN
cord-312386-88uwlmjx	181	4	for	for	IN
cord-312386-88uwlmjx	181	5	interleukin-27	interleukin-27	NN
cord-312386-88uwlmjx	181	6	(	(	-LRB-
cord-312386-88uwlmjx	181	7	IL-27	IL-27	NNP
cord-312386-88uwlmjx	181	8	)	)	-RRB-
cord-312386-88uwlmjx	181	9	as	as	IN
cord-312386-88uwlmjx	181	10	mediator	mediator	NN
cord-312386-88uwlmjx	181	11	of	of	IN
cord-312386-88uwlmjx	181	12	intestinal	intestinal	JJ
cord-312386-88uwlmjx	181	13	epithelial	epithelial	JJ
cord-312386-88uwlmjx	181	14	barrier	barrier	NN
cord-312386-88uwlmjx	181	15	protection	protection	NN
cord-312386-88uwlmjx	181	16	mediated	mediate	VBN
cord-312386-88uwlmjx	181	17	via	via	IN
cord-312386-88uwlmjx	181	18	differential	differential	JJ
cord-312386-88uwlmjx	181	19	signal	signal	NN
cord-312386-88uwlmjx	181	20	transducer	transducer	NN
cord-312386-88uwlmjx	181	21	and	and	CC
cord-312386-88uwlmjx	181	22	activator	activator	NN
cord-312386-88uwlmjx	181	23	of	of	IN
cord-312386-88uwlmjx	181	24	transcription	transcription	NN
cord-312386-88uwlmjx	181	25	(	(	-LRB-
cord-312386-88uwlmjx	181	26	STAT	stat	NN
cord-312386-88uwlmjx	181	27	)	)	-RRB-
cord-312386-88uwlmjx	181	28	protein	protein	NN
cord-312386-88uwlmjx	181	29	signaling	signaling	NN
cord-312386-88uwlmjx	181	30	and	and	CC
cord-312386-88uwlmjx	181	31	induction	induction	NN
cord-312386-88uwlmjx	181	32	of	of	IN
cord-312386-88uwlmjx	181	33	antibacterial	antibacterial	JJ
cord-312386-88uwlmjx	181	34	and	and	CC
cord-312386-88uwlmjx	181	35	anti	anti	JJ
cord-312386-88uwlmjx	181	36	-	-	JJ
cord-312386-88uwlmjx	181	37	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	181	38	proteins	protein	NNS
cord-312386-88uwlmjx	181	39	Activation	Activation	NNP
cord-312386-88uwlmjx	181	40	of	of	IN
cord-312386-88uwlmjx	181	41	signal	signal	NN
cord-312386-88uwlmjx	181	42	transducer	transducer	NN
cord-312386-88uwlmjx	181	43	and	and	CC
cord-312386-88uwlmjx	181	44	activator	activator	NN
cord-312386-88uwlmjx	181	45	of	of	IN
cord-312386-88uwlmjx	181	46	transcription-3	transcription-3	NN
cord-312386-88uwlmjx	182	1	(	(	-LRB-
cord-312386-88uwlmjx	182	2	stat3	stat3	NNP
cord-312386-88uwlmjx	182	3	)	)	-RRB-
cord-312386-88uwlmjx	182	4	expression	expression	NN
cord-312386-88uwlmjx	182	5	by	by	IN
cord-312386-88uwlmjx	182	6	interferon	interferon	NN
cord-312386-88uwlmjx	182	7	-	-	HYPH
cord-312386-88uwlmjx	182	8	gamma	gamma	NN
cord-312386-88uwlmjx	182	9	and	and	CC
cord-312386-88uwlmjx	182	10	interleukin-6	interleukin-6	NNP
cord-312386-88uwlmjx	183	1	in	in	IN
cord-312386-88uwlmjx	183	2	hepatoma	hepatoma	NNP
cord-312386-88uwlmjx	183	3	cells	cell	NNS
cord-312386-88uwlmjx	184	1	Tumor	tumor	NN
cord-312386-88uwlmjx	184	2	necrosis	necrosis	NN
cord-312386-88uwlmjx	184	3	factor	factor	NN
cord-312386-88uwlmjx	185	1	alpha	alpha	NNP
cord-312386-88uwlmjx	185	2	(	(	-LRB-
cord-312386-88uwlmjx	185	3	TNF	TNF	NNP
cord-312386-88uwlmjx	185	4	-	-	HYPH
cord-312386-88uwlmjx	185	5	alpha	alpha	NN
cord-312386-88uwlmjx	185	6	)	)	-RRB-
cord-312386-88uwlmjx	185	7	activates	activate	VBZ
cord-312386-88uwlmjx	185	8	Jak1	Jak1	NNP
cord-312386-88uwlmjx	185	9	/	/	SYM
cord-312386-88uwlmjx	185	10	Stat3-Stat5b	Stat3-Stat5b	NNP
cord-312386-88uwlmjx	185	11	signaling	signal	VBG
cord-312386-88uwlmjx	185	12	through	through	IN
cord-312386-88uwlmjx	185	13	TNFR-1	TNFR-1	NNP
cord-312386-88uwlmjx	185	14	in	in	IN
cord-312386-88uwlmjx	185	15	human	human	JJ
cord-312386-88uwlmjx	185	16	B	b	NN
cord-312386-88uwlmjx	185	17	cells	cell	NNS
cord-312386-88uwlmjx	185	18	LIGHT	light	NN
cord-312386-88uwlmjx	185	19	,	,	,
cord-312386-88uwlmjx	185	20	a	a	DT
cord-312386-88uwlmjx	185	21	member	member	NN
cord-312386-88uwlmjx	185	22	of	of	IN
cord-312386-88uwlmjx	185	23	the	the	DT
cord-312386-88uwlmjx	185	24	TNF	TNF	NNP
cord-312386-88uwlmjx	185	25	superfamily	superfamily	NN
cord-312386-88uwlmjx	185	26	,	,	,
cord-312386-88uwlmjx	185	27	activates	activate	VBZ
cord-312386-88uwlmjx	185	28	Stat3	Stat3	NNP
cord-312386-88uwlmjx	185	29	mediated	mediate	VBN
cord-312386-88uwlmjx	185	30	by	by	IN
cord-312386-88uwlmjx	185	31	NIK	NIK	NNP
cord-312386-88uwlmjx	185	32	pathway	pathway	NN
cord-312386-88uwlmjx	186	1	The	the	DT
cord-312386-88uwlmjx	186	2	chemokine	chemokine	NN
cord-312386-88uwlmjx	186	3	monocyte	monocyte	NNP
cord-312386-88uwlmjx	186	4	chemotactic	chemotactic	JJ
cord-312386-88uwlmjx	186	5	protein	protein	NN
cord-312386-88uwlmjx	186	6	1	1	CD
cord-312386-88uwlmjx	186	7	triggers	trigger	VBZ
cord-312386-88uwlmjx	186	8	Janus	Janus	NNP
cord-312386-88uwlmjx	186	9	kinase	kinase	NN
cord-312386-88uwlmjx	187	1	2	2	CD
cord-312386-88uwlmjx	187	2	activation	activation	NN
cord-312386-88uwlmjx	187	3	and	and	CC
cord-312386-88uwlmjx	187	4	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	187	5	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	187	6	of	of	IN
cord-312386-88uwlmjx	187	7	the	the	DT
cord-312386-88uwlmjx	187	8	CCR2B	ccr2b	NN
cord-312386-88uwlmjx	187	9	receptor	receptor	NN
cord-312386-88uwlmjx	187	10	RANTES	RANTES	NNP
cord-312386-88uwlmjx	187	11	and	and	CC
cord-312386-88uwlmjx	187	12	MIP-1alpha	MIP-1alpha	NNP
cord-312386-88uwlmjx	187	13	activate	activate	VB
cord-312386-88uwlmjx	187	14	Stats	Stats	NNP
cord-312386-88uwlmjx	187	15	in	in	IN
cord-312386-88uwlmjx	187	16	T	t	NN
cord-312386-88uwlmjx	187	17	cells	cell	NNS
cord-312386-88uwlmjx	187	18	Steel	Steel	NNP
cord-312386-88uwlmjx	187	19	factor	factor	NN
cord-312386-88uwlmjx	187	20	induces	induce	VBZ
cord-312386-88uwlmjx	187	21	serine	serine	JJ
cord-312386-88uwlmjx	187	22	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	187	23	of	of	IN
cord-312386-88uwlmjx	187	24	Stat3	Stat3	NNP
cord-312386-88uwlmjx	187	25	in	in	IN
cord-312386-88uwlmjx	187	26	human	human	JJ
cord-312386-88uwlmjx	187	27	growth	growth	NN
cord-312386-88uwlmjx	187	28	factor	factor	NN
cord-312386-88uwlmjx	187	29	-	-	HYPH
cord-312386-88uwlmjx	187	30	dependent	dependent	JJ
cord-312386-88uwlmjx	187	31	myeloid	myeloid	JJ
cord-312386-88uwlmjx	187	32	cell	cell	NN
cord-312386-88uwlmjx	187	33	lines	line	NNS
cord-312386-88uwlmjx	188	1	Oncostatin	Oncostatin	NNP
cord-312386-88uwlmjx	188	2	M	M	NNP
cord-312386-88uwlmjx	188	3	promotes	promote	VBZ
cord-312386-88uwlmjx	188	4	STAT3	STAT3	NNP
cord-312386-88uwlmjx	188	5	activation	activation	NN
cord-312386-88uwlmjx	188	6	,	,	,
cord-312386-88uwlmjx	188	7	VEGF	VEGF	NNP
cord-312386-88uwlmjx	188	8	production	production	NN
cord-312386-88uwlmjx	188	9	,	,	,
cord-312386-88uwlmjx	188	10	and	and	CC
cord-312386-88uwlmjx	188	11	invasion	invasion	NN
cord-312386-88uwlmjx	188	12	in	in	IN
cord-312386-88uwlmjx	188	13	osteosarcoma	osteosarcoma	NN
cord-312386-88uwlmjx	188	14	cell	cell	NN
cord-312386-88uwlmjx	188	15	lines	line	NNS
cord-312386-88uwlmjx	189	1	Small	small	JJ
cord-312386-88uwlmjx	189	2	molecule	molecule	NN
cord-312386-88uwlmjx	189	3	inhibitors	inhibitor	NNS
cord-312386-88uwlmjx	189	4	of	of	IN
cord-312386-88uwlmjx	189	5	signal	signal	NN
cord-312386-88uwlmjx	189	6	transducer	transducer	NN
cord-312386-88uwlmjx	189	7	and	and	CC
cord-312386-88uwlmjx	189	8	activator	activator	NN
cord-312386-88uwlmjx	189	9	of	of	IN
cord-312386-88uwlmjx	189	10	transcription	transcription	NN
cord-312386-88uwlmjx	189	11	3	3	CD
cord-312386-88uwlmjx	190	1	(	(	-LRB-
cord-312386-88uwlmjx	190	2	stat3	stat3	NNP
cord-312386-88uwlmjx	190	3	)	)	-RRB-
cord-312386-88uwlmjx	190	4	protein	protein	NN
cord-312386-88uwlmjx	190	5	Signal	Signal	NNP
cord-312386-88uwlmjx	190	6	transducer	transducer	NN
cord-312386-88uwlmjx	190	7	and	and	CC
cord-312386-88uwlmjx	190	8	activator	activator	NN
cord-312386-88uwlmjx	190	9	of	of	IN
cord-312386-88uwlmjx	190	10	transcription	transcription	NN
cord-312386-88uwlmjx	190	11	3	3	CD
cord-312386-88uwlmjx	190	12	in	in	IN
cord-312386-88uwlmjx	190	13	liver	liver	NN
cord-312386-88uwlmjx	190	14	diseases	disease	NNS
cord-312386-88uwlmjx	190	15	:	:	:
cord-312386-88uwlmjx	190	16	a	a	DT
cord-312386-88uwlmjx	190	17	novel	novel	JJ
cord-312386-88uwlmjx	190	18	therapeutic	therapeutic	JJ
cord-312386-88uwlmjx	190	19	8	8	CD
cord-312386-88uwlmjx	190	20	Journal	Journal	NNP
cord-312386-88uwlmjx	190	21	of	of	IN
cord-312386-88uwlmjx	190	22	Immunology	Immunology	NNP
cord-312386-88uwlmjx	190	23	Research	Research	NNP
cord-312386-88uwlmjx	190	24	target	target	NN
cord-312386-88uwlmjx	190	25	Role	role	NN
cord-312386-88uwlmjx	190	26	and	and	CC
cord-312386-88uwlmjx	190	27	regulation	regulation	NN
cord-312386-88uwlmjx	190	28	of	of	IN
cord-312386-88uwlmjx	190	29	STAT3	STAT3	NNP
cord-312386-88uwlmjx	190	30	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	190	31	at	at	IN
cord-312386-88uwlmjx	190	32	Ser727	ser727	CD
cord-312386-88uwlmjx	190	33	in	in	IN
cord-312386-88uwlmjx	190	34	melanocytes	melanocyte	NNS
cord-312386-88uwlmjx	190	35	and	and	CC
cord-312386-88uwlmjx	190	36	melanoma	melanoma	NN
cord-312386-88uwlmjx	190	37	cells	cell	NNS
cord-312386-88uwlmjx	190	38	STAT3	STAT3	VBN
cord-312386-88uwlmjx	190	39	as	as	IN
cord-312386-88uwlmjx	190	40	a	a	DT
cord-312386-88uwlmjx	190	41	central	central	JJ
cord-312386-88uwlmjx	190	42	mediator	mediator	NN
cord-312386-88uwlmjx	190	43	of	of	IN
cord-312386-88uwlmjx	190	44	neoplastic	neoplastic	JJ
cord-312386-88uwlmjx	190	45	cellular	cellular	JJ
cord-312386-88uwlmjx	190	46	transformation	transformation	NN
cord-312386-88uwlmjx	190	47	Reduced	reduce	VBN
cord-312386-88uwlmjx	190	48	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	190	49	of	of	IN
cord-312386-88uwlmjx	190	50	Stat3	Stat3	NNP
cord-312386-88uwlmjx	190	51	at	at	IN
cord-312386-88uwlmjx	190	52	Ser-727	Ser-727	NNP
cord-312386-88uwlmjx	190	53	mediated	mediate	VBN
cord-312386-88uwlmjx	190	54	by	by	IN
cord-312386-88uwlmjx	190	55	casein	casein	NN
cord-312386-88uwlmjx	190	56	kinase	kinase	NN
cord-312386-88uwlmjx	191	1	2-protein	2-protein	CD
cord-312386-88uwlmjx	191	2	phosphatase	phosphatase	NN
cord-312386-88uwlmjx	191	3	2A	2A	NNP
cord-312386-88uwlmjx	191	4	enhances	enhance	VBZ
cord-312386-88uwlmjx	191	5	Stat3	Stat3	NNP
cord-312386-88uwlmjx	191	6	Tyr-705	Tyr-705	NNP
cord-312386-88uwlmjx	191	7	induced	induce	VBD
cord-312386-88uwlmjx	191	8	tumorigenic	tumorigenic	JJ
cord-312386-88uwlmjx	191	9	potential	potential	NN
cord-312386-88uwlmjx	191	10	of	of	IN
cord-312386-88uwlmjx	191	11	glioma	glioma	NN
cord-312386-88uwlmjx	191	12	cells	cell	NNS
cord-312386-88uwlmjx	191	13	Regulation	regulation	NN
cord-312386-88uwlmjx	191	14	of	of	IN
cord-312386-88uwlmjx	191	15	Stat3	Stat3	NNP
cord-312386-88uwlmjx	191	16	nuclear	nuclear	JJ
cord-312386-88uwlmjx	191	17	import	import	NN
cord-312386-88uwlmjx	191	18	by	by	IN
cord-312386-88uwlmjx	191	19	importin	importin	NNP
cord-312386-88uwlmjx	191	20	5	5	CD
cord-312386-88uwlmjx	191	21	and	and	CC
cord-312386-88uwlmjx	191	22	importin	importin	NNP
cord-312386-88uwlmjx	191	23	7	7	CD
cord-312386-88uwlmjx	191	24	via	via	IN
cord-312386-88uwlmjx	191	25	two	two	CD
cord-312386-88uwlmjx	191	26	different	different	JJ
cord-312386-88uwlmjx	191	27	functional	functional	JJ
cord-312386-88uwlmjx	191	28	sequence	sequence	NN
cord-312386-88uwlmjx	191	29	elements	element	NNS
cord-312386-88uwlmjx	192	1	T40214	T40214	NNP
cord-312386-88uwlmjx	192	2	/	/	SYM
cord-312386-88uwlmjx	192	3	PEI	PEI	NNP
cord-312386-88uwlmjx	192	4	complex	complex	NN
cord-312386-88uwlmjx	192	5	:	:	:
cord-312386-88uwlmjx	192	6	a	a	DT
cord-312386-88uwlmjx	192	7	potent	potent	JJ
cord-312386-88uwlmjx	192	8	therapeutics	therapeutic	NNS
cord-312386-88uwlmjx	192	9	for	for	IN
cord-312386-88uwlmjx	192	10	prostate	prostate	NN
cord-312386-88uwlmjx	192	11	cancer	cancer	NN
cord-312386-88uwlmjx	192	12	that	that	WDT
cord-312386-88uwlmjx	192	13	targets	target	VBZ
cord-312386-88uwlmjx	192	14	STAT3	STAT3	NNP
cord-312386-88uwlmjx	192	15	signaling	signal	VBG
cord-312386-88uwlmjx	192	16	STAT3	stat3	CD
cord-312386-88uwlmjx	192	17	expression	expression	NN
cord-312386-88uwlmjx	192	18	in	in	IN
cord-312386-88uwlmjx	192	19	salivary	salivary	JJ
cord-312386-88uwlmjx	192	20	gland	gland	NN
cord-312386-88uwlmjx	192	21	tumours	tumour	NNS
cord-312386-88uwlmjx	193	1	Activated	Activated	NNP
cord-312386-88uwlmjx	193	2	STAT3	STAT3	NNP
cord-312386-88uwlmjx	193	3	is	be	VBZ
cord-312386-88uwlmjx	193	4	a	a	DT
cord-312386-88uwlmjx	193	5	mediator	mediator	NN
cord-312386-88uwlmjx	193	6	and	and	CC
cord-312386-88uwlmjx	193	7	biomarker	biomarker	NN
cord-312386-88uwlmjx	193	8	of	of	IN
cord-312386-88uwlmjx	193	9	VEGF	VEGF	NNP
cord-312386-88uwlmjx	193	10	endothelial	endothelial	JJ
cord-312386-88uwlmjx	193	11	activation	activation	NN
cord-312386-88uwlmjx	193	12	Unphosphorylated	Unphosphorylated	NNP
cord-312386-88uwlmjx	193	13	STAT3	STAT3	NNP
cord-312386-88uwlmjx	193	14	accumulates	accumulate	VBZ
cord-312386-88uwlmjx	193	15	in	in	IN
cord-312386-88uwlmjx	193	16	response	response	NN
cord-312386-88uwlmjx	193	17	to	to	IN
cord-312386-88uwlmjx	193	18	IL-6	IL-6	NNP
cord-312386-88uwlmjx	193	19	and	and	CC
cord-312386-88uwlmjx	193	20	activates	activate	VBZ
cord-312386-88uwlmjx	193	21	transcription	transcription	NN
cord-312386-88uwlmjx	193	22	by	by	IN
cord-312386-88uwlmjx	193	23	binding	bind	VBG
cord-312386-88uwlmjx	193	24	to	to	IN
cord-312386-88uwlmjx	193	25	NF	NF	NNP
cord-312386-88uwlmjx	193	26	B	B	NNP
cord-312386-88uwlmjx	193	27	Polypeptide	Polypeptide	NNP
cord-312386-88uwlmjx	193	28	signalling	signal	VBG
cord-312386-88uwlmjx	193	29	to	to	IN
cord-312386-88uwlmjx	193	30	the	the	DT
cord-312386-88uwlmjx	193	31	nucleus	nucleus	NN
cord-312386-88uwlmjx	193	32	through	through	IN
cord-312386-88uwlmjx	193	33	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	193	34	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	193	35	of	of	IN
cord-312386-88uwlmjx	193	36	Jak	Jak	NNP
cord-312386-88uwlmjx	193	37	and	and	CC
cord-312386-88uwlmjx	193	38	Stat	Stat	NNP
cord-312386-88uwlmjx	193	39	proteins	protein	NNS
cord-312386-88uwlmjx	193	40	Interferon	interferon	NN
cord-312386-88uwlmjx	193	41	-	-	HYPH
cord-312386-88uwlmjx	193	42	dependent	dependent	JJ
cord-312386-88uwlmjx	193	43	tyrosine	tyrosine	NN
cord-312386-88uwlmjx	193	44	phosphorylation	phosphorylation	NN
cord-312386-88uwlmjx	193	45	of	of	IN
cord-312386-88uwlmjx	193	46	a	a	DT
cord-312386-88uwlmjx	193	47	latent	latent	JJ
cord-312386-88uwlmjx	193	48	cytoplasmic	cytoplasmic	JJ
cord-312386-88uwlmjx	193	49	transcription	transcription	NN
cord-312386-88uwlmjx	193	50	factor	factor	NN
cord-312386-88uwlmjx	193	51	Principles	principle	NNS
cord-312386-88uwlmjx	193	52	of	of	IN
cord-312386-88uwlmjx	193	53	interleukin	interleukin	NN
cord-312386-88uwlmjx	193	54	(	(	-LRB-
cord-312386-88uwlmjx	193	55	IL)-6-type	IL)-6-type	NNP
cord-312386-88uwlmjx	193	56	cytokine	cytokine	NN
cord-312386-88uwlmjx	193	57	signalling	signalling	NN
cord-312386-88uwlmjx	193	58	and	and	CC
cord-312386-88uwlmjx	193	59	its	-PRON-	PRP$
cord-312386-88uwlmjx	193	60	regulation	regulation	NN
cord-312386-88uwlmjx	193	61	Inhibitors	Inhibitors	NNP
cord-312386-88uwlmjx	193	62	of	of	IN
cord-312386-88uwlmjx	193	63	cytokine	cytokine	NN
cord-312386-88uwlmjx	193	64	signal	signal	NN
cord-312386-88uwlmjx	193	65	transduction	transduction	NN
cord-312386-88uwlmjx	193	66	Nucleocytoplasmic	Nucleocytoplasmic	NNP
cord-312386-88uwlmjx	193	67	shuttling	shuttle	VBG
cord-312386-88uwlmjx	193	68	of	of	IN
cord-312386-88uwlmjx	193	69	persistently	persistently	RB
cord-312386-88uwlmjx	193	70	activated	activate	VBN
cord-312386-88uwlmjx	193	71	STAT3	STAT3	NNP
cord-312386-88uwlmjx	193	72	Regulation	regulation	NN
cord-312386-88uwlmjx	193	73	of	of	IN
cord-312386-88uwlmjx	193	74	cytokine	cytokine	NN
cord-312386-88uwlmjx	193	75	signaling	signal	VBG
cord-312386-88uwlmjx	193	76	pathways	pathway	NNS
cord-312386-88uwlmjx	193	77	by	by	IN
cord-312386-88uwlmjx	193	78	PIAS	PIAS	NNP
cord-312386-88uwlmjx	193	79	proteins	protein	NNS
cord-312386-88uwlmjx	193	80	Identification	Identification	NNP
cord-312386-88uwlmjx	193	81	of	of	IN
cord-312386-88uwlmjx	193	82	recurrent	recurrent	JJ
cord-312386-88uwlmjx	193	83	NAB2-STAT6	nab2-stat6	NN
cord-312386-88uwlmjx	193	84	gene	gene	NN
cord-312386-88uwlmjx	193	85	fusions	fusion	NNS
cord-312386-88uwlmjx	193	86	in	in	IN
cord-312386-88uwlmjx	193	87	solitary	solitary	JJ
cord-312386-88uwlmjx	193	88	fibrous	fibrous	JJ
cord-312386-88uwlmjx	193	89	tumor	tumor	NN
cord-312386-88uwlmjx	193	90	by	by	IN
cord-312386-88uwlmjx	193	91	integrative	integrative	JJ
cord-312386-88uwlmjx	193	92	sequencing	sequencing	NN
cord-312386-88uwlmjx	193	93	Somatic	somatic	JJ
cord-312386-88uwlmjx	193	94	STAT3	STAT3	NNP
cord-312386-88uwlmjx	193	95	mutations	mutation	NNS
cord-312386-88uwlmjx	193	96	in	in	IN
cord-312386-88uwlmjx	193	97	large	large	JJ
cord-312386-88uwlmjx	193	98	granular	granular	JJ
cord-312386-88uwlmjx	193	99	lymphocytic	lymphocytic	JJ
cord-312386-88uwlmjx	193	100	leukemia	leukemia	NN
cord-312386-88uwlmjx	193	101	Signal	signal	NN
cord-312386-88uwlmjx	193	102	transducer	transducer	NN
cord-312386-88uwlmjx	193	103	and	and	CC
cord-312386-88uwlmjx	193	104	activator	activator	NN
cord-312386-88uwlmjx	193	105	of	of	IN
cord-312386-88uwlmjx	193	106	transcription-3	transcription-3	NN
cord-312386-88uwlmjx	193	107	,	,	,
cord-312386-88uwlmjx	193	108	inflammation	inflammation	NN
cord-312386-88uwlmjx	193	109	,	,	,
cord-312386-88uwlmjx	193	110	and	and	CC
cord-312386-88uwlmjx	193	111	cancer	cancer	NN
cord-312386-88uwlmjx	193	112	:	:	:
cord-312386-88uwlmjx	194	1	how	how	WRB
cord-312386-88uwlmjx	194	2	intimate	intimate	JJ
cord-312386-88uwlmjx	194	3	is	be	VBZ
cord-312386-88uwlmjx	194	4	the	the	DT
cord-312386-88uwlmjx	194	5	relationship	relationship	NN
cord-312386-88uwlmjx	194	6	?	?	.
cord-312386-88uwlmjx	195	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	195	2	negatively	negatively	RB
cord-312386-88uwlmjx	195	3	regulates	regulate	VBZ
cord-312386-88uwlmjx	195	4	type	type	NN
cord-312386-88uwlmjx	195	5	I	-PRON-	PRP
cord-312386-88uwlmjx	195	6	IFN	IFN	NNP
cord-312386-88uwlmjx	195	7	-	-	HYPH
cord-312386-88uwlmjx	195	8	mediated	mediate	VBN
cord-312386-88uwlmjx	195	9	antiviral	antiviral	JJ
cord-312386-88uwlmjx	195	10	response	response	NN
cord-312386-88uwlmjx	195	11	Role	role	NN
cord-312386-88uwlmjx	195	12	of	of	IN
cord-312386-88uwlmjx	195	13	STAT3	STAT3	NNP
cord-312386-88uwlmjx	195	14	in	in	IN
cord-312386-88uwlmjx	195	15	type	type	NN
cord-312386-88uwlmjx	196	1	I	-PRON-	PRP
cord-312386-88uwlmjx	196	2	interferon	interferon	VBD
cord-312386-88uwlmjx	196	3	responses	response	NNS
cord-312386-88uwlmjx	196	4	:	:	:
cord-312386-88uwlmjx	196	5	negative	negative	JJ
cord-312386-88uwlmjx	196	6	regulation	regulation	NN
cord-312386-88uwlmjx	196	7	of	of	IN
cord-312386-88uwlmjx	196	8	STAT1-dependent	stat1-dependent	CD
cord-312386-88uwlmjx	196	9	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	196	10	gene	gene	NN
cord-312386-88uwlmjx	196	11	activation	activation	NN
cord-312386-88uwlmjx	196	12	Cutting	cutting	NN
cord-312386-88uwlmjx	196	13	edge	edge	NN
cord-312386-88uwlmjx	196	14	:	:	:
cord-312386-88uwlmjx	197	1	IL-10-independent	IL-10-independent	NNP
cord-312386-88uwlmjx	197	2	STAT3	stat3	CD
cord-312386-88uwlmjx	197	3	activation	activation	NN
cord-312386-88uwlmjx	197	4	by	by	IN
cord-312386-88uwlmjx	197	5	Toxoplasma	Toxoplasma	NNP
cord-312386-88uwlmjx	197	6	gondii	gondii	NN
cord-312386-88uwlmjx	197	7	mediates	mediate	VBZ
cord-312386-88uwlmjx	197	8	suppression	suppression	NN
cord-312386-88uwlmjx	197	9	of	of	IN
cord-312386-88uwlmjx	197	10	IL-12	IL-12	NNP
cord-312386-88uwlmjx	197	11	and	and	CC
cord-312386-88uwlmjx	197	12	TNF	TNF	NNP
cord-312386-88uwlmjx	197	13	-	-	HYPH
cord-312386-88uwlmjx	197	14	in	in	RP
cord-312386-88uwlmjx	197	15	host	host	NN
cord-312386-88uwlmjx	197	16	macrophages	macrophage	NNS
cord-312386-88uwlmjx	198	1	Interleukin-10	Interleukin-10	NNP
cord-312386-88uwlmjx	198	2	suppression	suppression	NN
cord-312386-88uwlmjx	198	3	of	of	IN
cord-312386-88uwlmjx	198	4	myeloid	myeloid	JJ
cord-312386-88uwlmjx	198	5	cell	cell	NN
cord-312386-88uwlmjx	198	6	activation	activation	NN
cord-312386-88uwlmjx	198	7	-A	-A	:
cord-312386-88uwlmjx	198	8	continuing	continue	VBG
cord-312386-88uwlmjx	198	9	puzzle	puzzle	NN
cord-312386-88uwlmjx	198	10	Toll	Toll	NNP
cord-312386-88uwlmjx	198	11	-	-	HYPH
cord-312386-88uwlmjx	198	12	like	like	JJ
cord-312386-88uwlmjx	198	13	receptor	receptor	NN
cord-312386-88uwlmjx	198	14	-	-	HYPH
cord-312386-88uwlmjx	198	15	dependent	dependent	JJ
cord-312386-88uwlmjx	198	16	production	production	NN
cord-312386-88uwlmjx	198	17	of	of	IN
cord-312386-88uwlmjx	198	18	IL-12p40	IL-12p40	NNP
cord-312386-88uwlmjx	198	19	causes	cause	VBZ
cord-312386-88uwlmjx	198	20	chronic	chronic	JJ
cord-312386-88uwlmjx	198	21	enterocolitis	enterocolitis	NN
cord-312386-88uwlmjx	198	22	in	in	IN
cord-312386-88uwlmjx	198	23	myeloid	myeloid	JJ
cord-312386-88uwlmjx	198	24	cell	cell	NN
cord-312386-88uwlmjx	198	25	-	-	HYPH
cord-312386-88uwlmjx	198	26	specific	specific	JJ
cord-312386-88uwlmjx	198	27	Stat3-deficient	Stat3-deficient	NNP
cord-312386-88uwlmjx	198	28	mice	mouse	NNS
cord-312386-88uwlmjx	198	29	Aberrant	aberrant	JJ
cord-312386-88uwlmjx	198	30	inflammation	inflammation	NN
cord-312386-88uwlmjx	198	31	and	and	CC
cord-312386-88uwlmjx	198	32	lethality	lethality	NN
cord-312386-88uwlmjx	198	33	to	to	IN
cord-312386-88uwlmjx	198	34	septic	septic	JJ
cord-312386-88uwlmjx	198	35	peritonitis	peritonitis	NN
cord-312386-88uwlmjx	198	36	in	in	IN
cord-312386-88uwlmjx	198	37	mice	mouse	NNS
cord-312386-88uwlmjx	198	38	lacking	lack	VBG
cord-312386-88uwlmjx	198	39	STAT3	STAT3	NNP
cord-312386-88uwlmjx	198	40	in	in	IN
cord-312386-88uwlmjx	198	41	macrophages	macrophage	NNS
cord-312386-88uwlmjx	198	42	and	and	CC
cord-312386-88uwlmjx	198	43	neutrophils	neutrophil	NNS
cord-312386-88uwlmjx	198	44	General	general	JJ
cord-312386-88uwlmjx	198	45	nature	nature	NN
cord-312386-88uwlmjx	198	46	of	of	IN
cord-312386-88uwlmjx	198	47	the	the	DT
cord-312386-88uwlmjx	198	48	STAT3-activated	STAT3-activated	NNP
cord-312386-88uwlmjx	198	49	anti	anti	JJ
cord-312386-88uwlmjx	198	50	-	-	JJ
cord-312386-88uwlmjx	198	51	inflammatory	inflammatory	JJ
cord-312386-88uwlmjx	198	52	response	response	NN
cord-312386-88uwlmjx	198	53	Epstein	Epstein	NNP
cord-312386-88uwlmjx	198	54	-	-	HYPH
cord-312386-88uwlmjx	198	55	Barr	Barr	NNP
cord-312386-88uwlmjx	198	56	virus	virus	NN
cord-312386-88uwlmjx	198	57	regulates	regulate	VBZ
cord-312386-88uwlmjx	198	58	STAT1	stat1	XX
cord-312386-88uwlmjx	198	59	through	through	IN
cord-312386-88uwlmjx	198	60	latent	latent	JJ
cord-312386-88uwlmjx	198	61	membrane	membrane	NN
cord-312386-88uwlmjx	198	62	protein	protein	NN
cord-312386-88uwlmjx	198	63	1	1	CD
cord-312386-88uwlmjx	198	64	Dengue	Dengue	NNP
cord-312386-88uwlmjx	198	65	virus	virus	NN
cord-312386-88uwlmjx	198	66	inhibits	inhibit	VBZ
cord-312386-88uwlmjx	198	67	alpha	alpha	NN
cord-312386-88uwlmjx	198	68	interferon	interferon	NN
cord-312386-88uwlmjx	198	69	signaling	signal	VBG
cord-312386-88uwlmjx	198	70	by	by	IN
cord-312386-88uwlmjx	198	71	reducing	reduce	VBG
cord-312386-88uwlmjx	198	72	STAT2	STAT2	NNS
cord-312386-88uwlmjx	198	73	expression	expression	NN
cord-312386-88uwlmjx	199	1	Epstein	Epstein	NNP
cord-312386-88uwlmjx	199	2	-	-	HYPH
cord-312386-88uwlmjx	199	3	barr	barr	NNP
cord-312386-88uwlmjx	199	4	virus	virus	NN
cord-312386-88uwlmjx	199	5	LMP1	LMP1	NNP
cord-312386-88uwlmjx	199	6	activates	activate	VBZ
cord-312386-88uwlmjx	199	7	EGFR	EGFR	NNP
cord-312386-88uwlmjx	199	8	,	,	,
cord-312386-88uwlmjx	199	9	STAT3	STAT3	NNP
cord-312386-88uwlmjx	199	10	,	,	,
cord-312386-88uwlmjx	199	11	and	and	CC
cord-312386-88uwlmjx	199	12	ERK	ERK	NNP
cord-312386-88uwlmjx	199	13	through	through	IN
cord-312386-88uwlmjx	199	14	effects	effect	NNS
cord-312386-88uwlmjx	199	15	on	on	IN
cord-312386-88uwlmjx	199	16	PKC	PKC	NNP
cord-312386-88uwlmjx	199	17	Human	Human	NNP
cord-312386-88uwlmjx	199	18	immunodeficiency	immunodeficiency	NN
cord-312386-88uwlmjx	199	19	virus	virus	NN
cord-312386-88uwlmjx	199	20	type	type	NN
cord-312386-88uwlmjx	199	21	1	1	CD
cord-312386-88uwlmjx	200	1	(	(	-LRB-
cord-312386-88uwlmjx	200	2	HIV-1	HIV-1	NNP
cord-312386-88uwlmjx	200	3	)	)	-RRB-
cord-312386-88uwlmjx	200	4	Nef	Nef	NNP
cord-312386-88uwlmjx	200	5	activates	activate	VBZ
cord-312386-88uwlmjx	200	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	200	7	in	in	IN
cord-312386-88uwlmjx	200	8	primary	primary	JJ
cord-312386-88uwlmjx	200	9	human	human	JJ
cord-312386-88uwlmjx	200	10	monocyte	monocyte	NNP
cord-312386-88uwlmjx	200	11	/	/	SYM
cord-312386-88uwlmjx	200	12	macrophages	macrophage	NNS
cord-312386-88uwlmjx	200	13	through	through	IN
cord-312386-88uwlmjx	200	14	the	the	DT
cord-312386-88uwlmjx	200	15	release	release	NN
cord-312386-88uwlmjx	200	16	of	of	IN
cord-312386-88uwlmjx	200	17	soluble	soluble	JJ
cord-312386-88uwlmjx	200	18	factors	factor	NNS
cord-312386-88uwlmjx	200	19	:	:	:
cord-312386-88uwlmjx	200	20	involvement	involvement	NN
cord-312386-88uwlmjx	200	21	of	of	IN
cord-312386-88uwlmjx	200	22	Nef	Nef	NNP
cord-312386-88uwlmjx	200	23	domains	domain	NNS
cord-312386-88uwlmjx	200	24	interacting	interact	VBG
cord-312386-88uwlmjx	200	25	with	with	IN
cord-312386-88uwlmjx	200	26	the	the	DT
cord-312386-88uwlmjx	200	27	cell	cell	NN
cord-312386-88uwlmjx	200	28	endocytotic	endocytotic	NN
cord-312386-88uwlmjx	200	29	machinery	machinery	NN
cord-312386-88uwlmjx	200	30	Extracellular	Extracellular	NNP
cord-312386-88uwlmjx	200	31	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	200	32	C	C	NNP
cord-312386-88uwlmjx	200	33	virus	virus	NN
cord-312386-88uwlmjx	200	34	core	core	NN
cord-312386-88uwlmjx	200	35	protein	protein	NN
cord-312386-88uwlmjx	200	36	activates	activate	VBZ
cord-312386-88uwlmjx	200	37	STAT3	STAT3	NNP
cord-312386-88uwlmjx	200	38	in	in	IN
cord-312386-88uwlmjx	200	39	human	human	JJ
cord-312386-88uwlmjx	200	40	monocytes	monocyte	NNS
cord-312386-88uwlmjx	200	41	/	/	SYM
cord-312386-88uwlmjx	200	42	macrophages	macrophage	NNS
cord-312386-88uwlmjx	200	43	/	/	SYM
cord-312386-88uwlmjx	200	44	dendritic	dendritic	JJ
cord-312386-88uwlmjx	200	45	cells	cell	NNS
cord-312386-88uwlmjx	200	46	via	via	IN
cord-312386-88uwlmjx	200	47	an	an	DT
cord-312386-88uwlmjx	200	48	IL-6	IL-6	NNP
cord-312386-88uwlmjx	200	49	autocrine	autocrine	JJ
cord-312386-88uwlmjx	200	50	pathway	pathway	NN
cord-312386-88uwlmjx	200	51	Human	Human	NNP
cord-312386-88uwlmjx	200	52	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	200	53	C	C	NNP
cord-312386-88uwlmjx	200	54	virus	virus	NN
cord-312386-88uwlmjx	201	1	NS5A	NS5A	NNP
cord-312386-88uwlmjx	202	1	protein	protein	NN
cord-312386-88uwlmjx	202	2	alters	alter	VBZ
cord-312386-88uwlmjx	202	3	intracellular	intracellular	JJ
cord-312386-88uwlmjx	202	4	calcium	calcium	NN
cord-312386-88uwlmjx	202	5	levels	level	NNS
cord-312386-88uwlmjx	202	6	,	,	,
cord-312386-88uwlmjx	202	7	induces	induce	VBZ
cord-312386-88uwlmjx	202	8	oxidative	oxidative	JJ
cord-312386-88uwlmjx	202	9	stress	stress	NN
cord-312386-88uwlmjx	202	10	,	,	,
cord-312386-88uwlmjx	202	11	and	and	CC
cord-312386-88uwlmjx	202	12	activates	activate	VBZ
cord-312386-88uwlmjx	202	13	STAT-3	STAT-3	NNP
cord-312386-88uwlmjx	202	14	and	and	CC
cord-312386-88uwlmjx	202	15	NF	nf	NN
cord-312386-88uwlmjx	202	16	-	-	HYPH
cord-312386-88uwlmjx	202	17	B	B	NNP
cord-312386-88uwlmjx	202	18	Mitochondrially	Mitochondrially	NNP
cord-312386-88uwlmjx	202	19	associated	associate	VBN
cord-312386-88uwlmjx	202	20	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	202	21	B	B	NNP
cord-312386-88uwlmjx	202	22	virus	virus	NN
cord-312386-88uwlmjx	202	23	X	x	NN
cord-312386-88uwlmjx	202	24	protein	protein	NN
cord-312386-88uwlmjx	202	25	constitutively	constitutively	RB
cord-312386-88uwlmjx	202	26	activates	activate	VBZ
cord-312386-88uwlmjx	202	27	transcription	transcription	NN
cord-312386-88uwlmjx	202	28	factors	factor	NNS
cord-312386-88uwlmjx	202	29	STAT-3	STAT-3	NNP
cord-312386-88uwlmjx	202	30	and	and	CC
cord-312386-88uwlmjx	202	31	NF	nf	NN
cord-312386-88uwlmjx	202	32	-	-	HYPH
cord-312386-88uwlmjx	202	33	kappa	kappa	NN
cord-312386-88uwlmjx	202	34	B	b	NN
cord-312386-88uwlmjx	202	35	via	via	IN
cord-312386-88uwlmjx	202	36	oxidative	oxidative	JJ
cord-312386-88uwlmjx	202	37	stress	stress	NN
cord-312386-88uwlmjx	202	38	Persistent	persistent	JJ
cord-312386-88uwlmjx	202	39	activation	activation	NN
cord-312386-88uwlmjx	202	40	of	of	IN
cord-312386-88uwlmjx	202	41	STAT3	STAT3	NNP
cord-312386-88uwlmjx	202	42	by	by	IN
cord-312386-88uwlmjx	202	43	latent	latent	JJ
cord-312386-88uwlmjx	202	44	Kaposi	Kaposi	NNP
cord-312386-88uwlmjx	202	45	's	's	POS
cord-312386-88uwlmjx	202	46	sarcoma	sarcoma	NN
cord-312386-88uwlmjx	202	47	-	-	HYPH
cord-312386-88uwlmjx	202	48	associated	associate	VBN
cord-312386-88uwlmjx	202	49	herpesvirus	herpesvirus	NN
cord-312386-88uwlmjx	202	50	infection	infection	NN
cord-312386-88uwlmjx	202	51	of	of	IN
cord-312386-88uwlmjx	202	52	endothelial	endothelial	JJ
cord-312386-88uwlmjx	202	53	cells	cell	NNS
cord-312386-88uwlmjx	202	54	Activation	activation	NN
cord-312386-88uwlmjx	202	55	of	of	IN
cord-312386-88uwlmjx	202	56	Stat3	stat3	JJ
cord-312386-88uwlmjx	202	57	transcription	transcription	NN
cord-312386-88uwlmjx	202	58	factor	factor	NN
cord-312386-88uwlmjx	202	59	by	by	IN
cord-312386-88uwlmjx	202	60	Herpesvirus	Herpesvirus	NNP
cord-312386-88uwlmjx	202	61	saimiri	saimiri	NNP
cord-312386-88uwlmjx	202	62	STP-	STP-	NNP
cord-312386-88uwlmjx	203	1	A	a	DT
cord-312386-88uwlmjx	203	2	oncoprotein	oncoprotein	NNP
cord-312386-88uwlmjx	203	3	Signal	Signal	NNP
cord-312386-88uwlmjx	203	4	transducer	transducer	NN
cord-312386-88uwlmjx	203	5	and	and	CC
cord-312386-88uwlmjx	203	6	activator	activator	NN
cord-312386-88uwlmjx	203	7	of	of	IN
cord-312386-88uwlmjx	203	8	transcription	transcription	NN
cord-312386-88uwlmjx	203	9	3	3	CD
cord-312386-88uwlmjx	203	10	(	(	-LRB-
cord-312386-88uwlmjx	203	11	STAT3	STAT3	NNP
cord-312386-88uwlmjx	203	12	)	)	-RRB-
cord-312386-88uwlmjx	203	13	and	and	CC
cord-312386-88uwlmjx	203	14	survivin	survivin	NN
cord-312386-88uwlmjx	203	15	induction	induction	NN
cord-312386-88uwlmjx	203	16	by	by	IN
cord-312386-88uwlmjx	203	17	varicella	varicella	NN
cord-312386-88uwlmjx	203	18	-	-	HYPH
cord-312386-88uwlmjx	203	19	zoster	zoster	NN
cord-312386-88uwlmjx	203	20	virus	virus	NN
cord-312386-88uwlmjx	203	21	promote	promote	VBP
cord-312386-88uwlmjx	203	22	replication	replication	NN
cord-312386-88uwlmjx	203	23	and	and	CC
cord-312386-88uwlmjx	203	24	skin	skin	NN
cord-312386-88uwlmjx	203	25	pathogenesis	pathogenesis	NN
cord-312386-88uwlmjx	203	26	Influenza	Influenza	NNP
cord-312386-88uwlmjx	203	27	virus	virus	NN
cord-312386-88uwlmjx	204	1	nonstructural	nonstructural	JJ
cord-312386-88uwlmjx	204	2	protein	protein	NNP
cord-312386-88uwlmjx	204	3	1	1	CD
cord-312386-88uwlmjx	204	4	(	(	-LRB-
cord-312386-88uwlmjx	204	5	NS1	NS1	NNS
cord-312386-88uwlmjx	204	6	)	)	-RRB-
cord-312386-88uwlmjx	204	7	disrupts	disrupt	VBZ
cord-312386-88uwlmjx	204	8	interferon	interferon	NN
cord-312386-88uwlmjx	204	9	signaling	signal	VBG
cord-312386-88uwlmjx	204	10	Human	Human	NNP
cord-312386-88uwlmjx	204	11	metapneumovirus	metapneumovirus	NN
cord-312386-88uwlmjx	205	1	inhibits	inhibit	VBZ
cord-312386-88uwlmjx	205	2	the	the	DT
cord-312386-88uwlmjx	205	3	IL-6-induced	il-6-induced	JJ
cord-312386-88uwlmjx	205	4	JAK	JAK	NNP
cord-312386-88uwlmjx	205	5	/	/	SYM
cord-312386-88uwlmjx	205	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	205	7	signalling	signal	VBG
cord-312386-88uwlmjx	205	8	cascade	cascade	NN
cord-312386-88uwlmjx	205	9	in	in	IN
cord-312386-88uwlmjx	205	10	airway	airway	NN
cord-312386-88uwlmjx	205	11	epithelium	epithelium	NN
cord-312386-88uwlmjx	205	12	Human	Human	NNP
cord-312386-88uwlmjx	205	13	cytomegalovirus	cytomegalovirus	NNP
cord-312386-88uwlmjx	205	14	IE1	ie1	NN
cord-312386-88uwlmjx	205	15	protein	protein	NN
cord-312386-88uwlmjx	205	16	disrupts	disrupt	VBZ
cord-312386-88uwlmjx	205	17	interleukin-6	interleukin-6	NNP
cord-312386-88uwlmjx	205	18	signaling	signal	VBG
cord-312386-88uwlmjx	205	19	by	by	IN
cord-312386-88uwlmjx	205	20	sequestering	sequester	VBG
cord-312386-88uwlmjx	205	21	STAT3	STAT3	NNP
cord-312386-88uwlmjx	205	22	in	in	IN
cord-312386-88uwlmjx	205	23	the	the	DT
cord-312386-88uwlmjx	205	24	nucleus	nucleus	NN
cord-312386-88uwlmjx	205	25	Tyrosine	Tyrosine	NNP
cord-312386-88uwlmjx	205	26	dephosphorylation	dephosphorylation	NN
cord-312386-88uwlmjx	205	27	of	of	IN
cord-312386-88uwlmjx	205	28	STAT3	STAT3	NNP
cord-312386-88uwlmjx	205	29	in	in	IN
cord-312386-88uwlmjx	206	1	SARS	SARS	NNP
cord-312386-88uwlmjx	206	2	coronavirus	coronavirus	NN
cord-312386-88uwlmjx	206	3	-	-	HYPH
cord-312386-88uwlmjx	206	4	infected	infect	VBN
cord-312386-88uwlmjx	206	5	Vero	Vero	NNP
cord-312386-88uwlmjx	206	6	E6	E6	NNP
cord-312386-88uwlmjx	206	7	cells	cell	NNS
cord-312386-88uwlmjx	207	1	Hepatitis	Hepatitis	NNP
cord-312386-88uwlmjx	207	2	C	C	NNP
cord-312386-88uwlmjx	207	3	virus	virus	NN
cord-312386-88uwlmjx	207	4	targets	target	VBZ
cord-312386-88uwlmjx	207	5	the	the	DT
cord-312386-88uwlmjx	207	6	interferon	interferon	NN
cord-312386-88uwlmjx	207	7	-	-	HYPH
cord-312386-88uwlmjx	207	8	JAK	JAK	NNP
cord-312386-88uwlmjx	207	9	/	/	SYM
cord-312386-88uwlmjx	207	10	STAT	stat	NN
cord-312386-88uwlmjx	207	11	pathway	pathway	NN
cord-312386-88uwlmjx	207	12	by	by	IN
cord-312386-88uwlmjx	207	13	promoting	promote	VBG
cord-312386-88uwlmjx	207	14	proteasomal	proteasomal	JJ
cord-312386-88uwlmjx	207	15	degradation	degradation	NN
cord-312386-88uwlmjx	207	16	in	in	IN
cord-312386-88uwlmjx	207	17	immune	immune	JJ
cord-312386-88uwlmjx	207	18	cells	cell	NNS
cord-312386-88uwlmjx	207	19	and	and	CC
cord-312386-88uwlmjx	207	20	hepatocytes	hepatocyte	NNS
cord-312386-88uwlmjx	207	21	Stat3	Stat3	NNP
cord-312386-88uwlmjx	207	22	activation	activation	NN
cord-312386-88uwlmjx	207	23	is	be	VBZ
cord-312386-88uwlmjx	207	24	responsible	responsible	JJ
cord-312386-88uwlmjx	207	25	for	for	IN
cord-312386-88uwlmjx	207	26	IL-6-dependent	il-6-dependent	CD
cord-312386-88uwlmjx	207	27	T	T	NNP
cord-312386-88uwlmjx	207	28	cell	cell	NN
cord-312386-88uwlmjx	207	29	proliferation	proliferation	NN
cord-312386-88uwlmjx	207	30	through	through	IN
cord-312386-88uwlmjx	207	31	preventing	prevent	VBG
cord-312386-88uwlmjx	207	32	apoptosis	apoptosis	NN
cord-312386-88uwlmjx	207	33	:	:	:
cord-312386-88uwlmjx	207	34	generation	generation	NN
cord-312386-88uwlmjx	207	35	and	and	CC
cord-312386-88uwlmjx	207	36	characterization	characterization	NN
cord-312386-88uwlmjx	207	37	of	of	IN
cord-312386-88uwlmjx	207	38	T	T	NNP
cord-312386-88uwlmjx	207	39	cell	cell	NN
cord-312386-88uwlmjx	207	40	-	-	HYPH
cord-312386-88uwlmjx	207	41	specific	specific	JJ
cord-312386-88uwlmjx	207	42	stat3-deficient	stat3-deficient	JJ
cord-312386-88uwlmjx	207	43	mice	mouse	NNS
cord-312386-88uwlmjx	207	44	STAT3	STAT3	NNP
cord-312386-88uwlmjx	208	1	protein	protein	NNP
cord-312386-88uwlmjx	208	2	promotes	promote	VBZ
cord-312386-88uwlmjx	208	3	T	t	NN
cord-312386-88uwlmjx	208	4	-	-	HYPH
cord-312386-88uwlmjx	208	5	cell	cell	NN
cord-312386-88uwlmjx	208	6	survival	survival	NN
cord-312386-88uwlmjx	208	7	and	and	CC
cord-312386-88uwlmjx	208	8	inhibits	inhibit	NNS
cord-312386-88uwlmjx	208	9	interleukin-2	interleukin-2	IN
cord-312386-88uwlmjx	208	10	production	production	NN
cord-312386-88uwlmjx	208	11	through	through	IN
cord-312386-88uwlmjx	208	12	up	up	IN
cord-312386-88uwlmjx	208	13	-	-	HYPH
cord-312386-88uwlmjx	208	14	regulation	regulation	NN
cord-312386-88uwlmjx	208	15	of	of	IN
cord-312386-88uwlmjx	208	16	class	class	NN
cord-312386-88uwlmjx	208	17	O	o	NN
cord-312386-88uwlmjx	208	18	forkhead	forkhead	NN
cord-312386-88uwlmjx	208	19	transcription	transcription	NN
cord-312386-88uwlmjx	208	20	factors	factor	NNS
cord-312386-88uwlmjx	209	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	209	2	regulates	regulate	VBZ
cord-312386-88uwlmjx	209	3	proliferation	proliferation	NN
cord-312386-88uwlmjx	209	4	and	and	CC
cord-312386-88uwlmjx	209	5	survival	survival	NN
cord-312386-88uwlmjx	209	6	of	of	IN
cord-312386-88uwlmjx	209	7	CD8	CD8	NNP
cord-312386-88uwlmjx	209	8	+	+	CC
cord-312386-88uwlmjx	209	9	T	T	NNP
cord-312386-88uwlmjx	209	10	cells	cell	NNS
cord-312386-88uwlmjx	209	11	:	:	:
cord-312386-88uwlmjx	209	12	enhances	enhance	VBZ
cord-312386-88uwlmjx	209	13	effector	effector	NN
cord-312386-88uwlmjx	209	14	responses	response	NNS
cord-312386-88uwlmjx	209	15	to	to	IN
cord-312386-88uwlmjx	209	16	HSV-1	hsv-1	NN
cord-312386-88uwlmjx	209	17	infection	infection	NN
cord-312386-88uwlmjx	209	18	,	,	,
cord-312386-88uwlmjx	209	19	and	and	CC
cord-312386-88uwlmjx	209	20	inhibits	inhibit	VBZ
cord-312386-88uwlmjx	209	21	IL-10	IL-10	NNP
cord-312386-88uwlmjx	209	22	+	+	CC
cord-312386-88uwlmjx	209	23	regulatory	regulatory	JJ
cord-312386-88uwlmjx	209	24	CD8	CD8	NNP
cord-312386-88uwlmjx	209	25	+	+	CC
cord-312386-88uwlmjx	209	26	T	T	NNP
cord-312386-88uwlmjx	209	27	cells	cell	NNS
cord-312386-88uwlmjx	209	28	in	in	IN
cord-312386-88uwlmjx	209	29	autoimmune	autoimmune	JJ
cord-312386-88uwlmjx	209	30	uveitis	uveitis	NN
cord-312386-88uwlmjx	209	31	Interaction	Interaction	NNP
cord-312386-88uwlmjx	209	32	between	between	IN
cord-312386-88uwlmjx	209	33	STAT-3	STAT-3	NNP
cord-312386-88uwlmjx	209	34	and	and	CC
cord-312386-88uwlmjx	209	35	HNF-3	HNF-3	NNP
cord-312386-88uwlmjx	209	36	leads	lead	VBZ
cord-312386-88uwlmjx	209	37	to	to	IN
cord-312386-88uwlmjx	209	38	the	the	DT
cord-312386-88uwlmjx	209	39	activation	activation	NN
cord-312386-88uwlmjx	209	40	of	of	IN
cord-312386-88uwlmjx	209	41	liver	liver	NN
cord-312386-88uwlmjx	209	42	-	-	HYPH
cord-312386-88uwlmjx	209	43	specific	specific	JJ
cord-312386-88uwlmjx	209	44	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	209	45	B	b	NN
cord-312386-88uwlmjx	209	46	virus	virus	NN
cord-312386-88uwlmjx	209	47	enhancer	enhancer	NN
cord-312386-88uwlmjx	210	1	1	1	CD
cord-312386-88uwlmjx	210	2	function	function	NN
cord-312386-88uwlmjx	210	3	Hepatitis	Hepatitis	NNP
cord-312386-88uwlmjx	210	4	C	C	NNP
cord-312386-88uwlmjx	210	5	virus	virus	NN
cord-312386-88uwlmjx	210	6	(	(	-LRB-
cord-312386-88uwlmjx	210	7	HCV	HCV	NNP
cord-312386-88uwlmjx	210	8	)	)	-RRB-
cord-312386-88uwlmjx	210	9	constitutively	constitutively	RB
cord-312386-88uwlmjx	210	10	activates	activate	VBZ
cord-312386-88uwlmjx	210	11	STAT-3	STAT-3	NNP
cord-312386-88uwlmjx	210	12	via	via	IN
cord-312386-88uwlmjx	210	13	oxidative	oxidative	JJ
cord-312386-88uwlmjx	210	14	stress	stress	NN
cord-312386-88uwlmjx	210	15	:	:	:
cord-312386-88uwlmjx	210	16	role	role	NN
cord-312386-88uwlmjx	210	17	of	of	IN
cord-312386-88uwlmjx	210	18	STAT-3	STAT-3	NNP
cord-312386-88uwlmjx	210	19	in	in	IN
cord-312386-88uwlmjx	210	20	HCV	HCV	NNP
cord-312386-88uwlmjx	210	21	replication	replication	NN
cord-312386-88uwlmjx	211	1	STAT3	STAT3	NNP
cord-312386-88uwlmjx	211	2	ubiquitylation	ubiquitylation	NN
cord-312386-88uwlmjx	211	3	and	and	CC
cord-312386-88uwlmjx	211	4	degradation	degradation	NN
cord-312386-88uwlmjx	211	5	by	by	IN
cord-312386-88uwlmjx	211	6	mumps	mumps	NN
cord-312386-88uwlmjx	211	7	virus	virus	NN
cord-312386-88uwlmjx	211	8	suppress	suppress	VBP
cord-312386-88uwlmjx	211	9	cytokine	cytokine	NN
cord-312386-88uwlmjx	211	10	and	and	CC
cord-312386-88uwlmjx	211	11	oncogene	oncogene	NN
cord-312386-88uwlmjx	211	12	signaling	signal	VBG
cord-312386-88uwlmjx	211	13	STAT	stat	NN
cord-312386-88uwlmjx	211	14	protein	protein	NN
cord-312386-88uwlmjx	211	15	interference	interference	NN
cord-312386-88uwlmjx	211	16	and	and	CC
cord-312386-88uwlmjx	211	17	suppression	suppression	NN
cord-312386-88uwlmjx	211	18	of	of	IN
cord-312386-88uwlmjx	211	19	cytokine	cytokine	NN
cord-312386-88uwlmjx	211	20	signal	signal	NN
cord-312386-88uwlmjx	211	21	transduction	transduction	NN
cord-312386-88uwlmjx	211	22	by	by	IN
cord-312386-88uwlmjx	211	23	measles	measle	NNS
cord-312386-88uwlmjx	211	24	virus	virus	NN
cord-312386-88uwlmjx	211	25	V	v	NN
cord-312386-88uwlmjx	211	26	protein	protein	NN
cord-312386-88uwlmjx	212	1	The	the	DT
cord-312386-88uwlmjx	212	2	multifunctional	multifunctional	JJ
cord-312386-88uwlmjx	212	3	NS1	ns1	NN
cord-312386-88uwlmjx	212	4	protein	protein	NN
cord-312386-88uwlmjx	212	5	of	of	IN
cord-312386-88uwlmjx	212	6	influenza	influenza	NN
cord-312386-88uwlmjx	212	7	A	a	NN
cord-312386-88uwlmjx	212	8	viruses	virus	NNS
cord-312386-88uwlmjx	212	9	Dangerous	dangerous	JJ
cord-312386-88uwlmjx	212	10	liaisons	liaison	NNS
cord-312386-88uwlmjx	212	11	:	:	:
cord-312386-88uwlmjx	212	12	STAT3	STAT3	NNP
cord-312386-88uwlmjx	212	13	and	and	CC
cord-312386-88uwlmjx	212	14	NF	NF	NNP
cord-312386-88uwlmjx	212	15	-	-	HYPH
cord-312386-88uwlmjx	212	16	kappaB	kappaB	NNP
cord-312386-88uwlmjx	212	17	collaboration	collaboration	NN
cord-312386-88uwlmjx	212	18	and	and	CC
cord-312386-88uwlmjx	212	19	crosstalk	crosstalk	NN
cord-312386-88uwlmjx	212	20	in	in	IN
cord-312386-88uwlmjx	212	21	cancer	cancer	NN
cord-312386-88uwlmjx	212	22	STAT3	stat3	CD
cord-312386-88uwlmjx	212	23	activation	activation	NN
cord-312386-88uwlmjx	212	24	induced	induce	VBN
cord-312386-88uwlmjx	212	25	by	by	IN
cord-312386-88uwlmjx	212	26	Epstein	Epstein	NNP
cord-312386-88uwlmjx	212	27	-	-	HYPH
cord-312386-88uwlmjx	212	28	Barr	Barr	NNP
cord-312386-88uwlmjx	212	29	virus	virus	NN
cord-312386-88uwlmjx	212	30	latent	latent	NN
cord-312386-88uwlmjx	212	31	membrane	membrane	NN
cord-312386-88uwlmjx	212	32	protein1	protein1	NN
cord-312386-88uwlmjx	212	33	causes	cause	VBZ
cord-312386-88uwlmjx	212	34	vascular	vascular	JJ
cord-312386-88uwlmjx	212	35	endothelial	endothelial	JJ
cord-312386-88uwlmjx	212	36	growth	growth	NN
cord-312386-88uwlmjx	212	37	factor	factor	NN
cord-312386-88uwlmjx	212	38	expression	expression	NN
cord-312386-88uwlmjx	212	39	and	and	CC
cord-312386-88uwlmjx	212	40	cellular	cellular	JJ
cord-312386-88uwlmjx	212	41	invasiveness	invasiveness	NN
cord-312386-88uwlmjx	212	42	via	via	IN
cord-312386-88uwlmjx	212	43	JAK3	JAK3	NNP
cord-312386-88uwlmjx	213	1	and	and	CC
cord-312386-88uwlmjx	213	2	ERK	ERK	NNP
cord-312386-88uwlmjx	213	3	signaling	signal	VBG
cord-312386-88uwlmjx	213	4	Activation	activation	NN
cord-312386-88uwlmjx	213	5	of	of	IN
cord-312386-88uwlmjx	213	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	213	7	by	by	IN
cord-312386-88uwlmjx	213	8	the	the	DT
cord-312386-88uwlmjx	213	9	hepatitis	hepatitis	NN
cord-312386-88uwlmjx	213	10	C	C	NNP
cord-312386-88uwlmjx	213	11	virus	virus	NN
cord-312386-88uwlmjx	213	12	core	core	NN
cord-312386-88uwlmjx	213	13	protein	protein	NN
cord-312386-88uwlmjx	214	1	leads	lead	VBZ
cord-312386-88uwlmjx	214	2	to	to	IN
cord-312386-88uwlmjx	214	3	cellular	cellular	JJ
cord-312386-88uwlmjx	214	4	transformation	transformation	NN
cord-312386-88uwlmjx	215	1	HCMV	HCMV	NNP
cord-312386-88uwlmjx	215	2	activates	activate	VBZ
cord-312386-88uwlmjx	215	3	the	the	DT
cord-312386-88uwlmjx	215	4	IL-6-JAK	il-6-jak	NN
cord-312386-88uwlmjx	215	5	-	-	HYPH
cord-312386-88uwlmjx	215	6	STAT3	STAT3	NNP
cord-312386-88uwlmjx	215	7	axis	axis	NN
cord-312386-88uwlmjx	215	8	in	in	IN
cord-312386-88uwlmjx	215	9	HepG2	HepG2	NNP
cord-312386-88uwlmjx	215	10	cells	cell	NNS
cord-312386-88uwlmjx	215	11	and	and	CC
cord-312386-88uwlmjx	215	12	primary	primary	JJ
cord-312386-88uwlmjx	215	13	human	human	JJ
cord-312386-88uwlmjx	215	14	hepatocytes	hepatocyte	NNS
cord-312386-88uwlmjx	216	1	Innate	innate	JJ
cord-312386-88uwlmjx	216	2	defense	defense	NN
cord-312386-88uwlmjx	216	3	mechanism	mechanism	NN
cord-312386-88uwlmjx	216	4	against	against	IN
cord-312386-88uwlmjx	216	5	virus	virus	NN
cord-312386-88uwlmjx	216	6	infection	infection	NN
cord-312386-88uwlmjx	216	7	within	within	IN
cord-312386-88uwlmjx	216	8	the	the	DT
cord-312386-88uwlmjx	216	9	cardiac	cardiac	NN
cord-312386-88uwlmjx	216	10	myocyte	myocyte	NN
cord-312386-88uwlmjx	216	11	requiring	require	VBG
cord-312386-88uwlmjx	216	12	gp130-STAT3	gp130-STAT3	NNP
cord-312386-88uwlmjx	216	13	signaling	signal	VBG
cord-312386-88uwlmjx	216	14	Innate	innate	JJ
cord-312386-88uwlmjx	216	15	immunity	immunity	NN
cord-312386-88uwlmjx	216	16	to	to	IN
cord-312386-88uwlmjx	216	17	H5N1	H5N1	NNP
cord-312386-88uwlmjx	216	18	influenza	influenza	NN
cord-312386-88uwlmjx	216	19	viruses	virus	NNS
cord-312386-88uwlmjx	216	20	in	in	IN
cord-312386-88uwlmjx	216	21	humans	human	NNS
cord-312386-88uwlmjx	216	22	Induction	Induction	NNP
cord-312386-88uwlmjx	216	23	of	of	IN
cord-312386-88uwlmjx	216	24	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	216	25	cytokines	cytokine	NNS
cord-312386-88uwlmjx	216	26	in	in	IN
cord-312386-88uwlmjx	216	27	human	human	JJ
cord-312386-88uwlmjx	216	28	macrophages	macrophage	NNS
cord-312386-88uwlmjx	216	29	by	by	IN
cord-312386-88uwlmjx	216	30	influenza	influenza	NN
cord-312386-88uwlmjx	216	31	A	a	NN
cord-312386-88uwlmjx	216	32	(	(	-LRB-
cord-312386-88uwlmjx	216	33	H5N1	H5N1	NNP
cord-312386-88uwlmjx	216	34	)	)	-RRB-
cord-312386-88uwlmjx	216	35	viruses	virus	NNS
cord-312386-88uwlmjx	216	36	:	:	:
cord-312386-88uwlmjx	216	37	a	a	DT
cord-312386-88uwlmjx	216	38	mechanism	mechanism	NN
cord-312386-88uwlmjx	216	39	for	for	IN
cord-312386-88uwlmjx	216	40	the	the	DT
cord-312386-88uwlmjx	216	41	unusual	unusual	JJ
cord-312386-88uwlmjx	216	42	severity	severity	NN
cord-312386-88uwlmjx	216	43	of	of	IN
cord-312386-88uwlmjx	216	44	human	human	JJ
cord-312386-88uwlmjx	216	45	disease	disease	NN
cord-312386-88uwlmjx	216	46	?	?	.
cord-312386-88uwlmjx	217	1	Pathogenesis	Pathogenesis	NNP
cord-312386-88uwlmjx	217	2	of	of	IN
cord-312386-88uwlmjx	217	3	Hong	Hong	NNP
cord-312386-88uwlmjx	217	4	Kong	Kong	NNP
cord-312386-88uwlmjx	217	5	H5N1	H5N1	NNP
cord-312386-88uwlmjx	218	1	influenza	influenza	NN
cord-312386-88uwlmjx	218	2	virus	virus	NN
cord-312386-88uwlmjx	218	3	NS	NS	NNP
cord-312386-88uwlmjx	218	4	gene	gene	NN
cord-312386-88uwlmjx	218	5	reassortants	reassortant	NNS
cord-312386-88uwlmjx	218	6	in	in	IN
cord-312386-88uwlmjx	218	7	mice	mice	NN
cord-312386-88uwlmjx	218	8	:	:	:
cord-312386-88uwlmjx	219	1	the	the	DT
cord-312386-88uwlmjx	219	2	role	role	NN
cord-312386-88uwlmjx	219	3	of	of	IN
cord-312386-88uwlmjx	219	4	cytokines	cytokine	NNS
cord-312386-88uwlmjx	219	5	and	and	CC
cord-312386-88uwlmjx	219	6	B	b	NN
cord-312386-88uwlmjx	219	7	-	-	:
cord-312386-88uwlmjx	219	8	and	and	CC
cord-312386-88uwlmjx	219	9	T	t	NN
cord-312386-88uwlmjx	219	10	-	-	HYPH
cord-312386-88uwlmjx	219	11	cell	cell	NN
cord-312386-88uwlmjx	219	12	responses	response	NNS
cord-312386-88uwlmjx	219	13	Highly	highly	RB
cord-312386-88uwlmjx	219	14	pathogenic	pathogenic	JJ
cord-312386-88uwlmjx	219	15	avian	avian	JJ
cord-312386-88uwlmjx	219	16	influenza	influenza	NN
cord-312386-88uwlmjx	219	17	virus	virus	NN
cord-312386-88uwlmjx	219	18	infection	infection	NN
cord-312386-88uwlmjx	219	19	in	in	IN
cord-312386-88uwlmjx	219	20	chickens	chicken	NNS
cord-312386-88uwlmjx	219	21	but	but	CC
cord-312386-88uwlmjx	219	22	not	not	RB
cord-312386-88uwlmjx	219	23	ducks	duck	NNS
cord-312386-88uwlmjx	219	24	is	be	VBZ
cord-312386-88uwlmjx	219	25	associated	associate	VBN
cord-312386-88uwlmjx	219	26	with	with	IN
cord-312386-88uwlmjx	219	27	elevated	elevated	JJ
cord-312386-88uwlmjx	219	28	host	host	NN
cord-312386-88uwlmjx	219	29	immune	immune	NN
cord-312386-88uwlmjx	219	30	and	and	CC
cord-312386-88uwlmjx	219	31	proinflammatory	proinflammatory	JJ
cord-312386-88uwlmjx	219	32	responses	response	NNS