id	sid	tid	token	lemma	pos
cord-337365-hugenn14	1	1	key	key	NN
cord-337365-hugenn14	1	2	:	:	:
cord-337365-hugenn14	2	1	cord-337365-hugenn14	cord-337365-hugenn14	VBN
cord-337365-hugenn14	3	1	authors	author	NNS
cord-337365-hugenn14	3	2	:	:	:
cord-337365-hugenn14	3	3	Chen	Chen	NNP
cord-337365-hugenn14	3	4	,	,	,
cord-337365-hugenn14	3	5	Zhuangzhuang	Zhuangzhuang	NNP
cord-337365-hugenn14	3	6	;	;	:
cord-337365-hugenn14	3	7	Zhong	Zhong	NNP
cord-337365-hugenn14	3	8	,	,	,
cord-337365-hugenn14	3	9	Di	Di	NNP
cord-337365-hugenn14	3	10	;	;	:
cord-337365-hugenn14	3	11	Li	Li	NNP
cord-337365-hugenn14	3	12	,	,	,
cord-337365-hugenn14	4	1	Guozhong	Guozhong	NNP
cord-337365-hugenn14	4	2	title	title	NN
cord-337365-hugenn14	4	3	:	:	:
cord-337365-hugenn14	5	1	The	the	DT
cord-337365-hugenn14	5	2	role	role	NN
cord-337365-hugenn14	5	3	of	of	IN
cord-337365-hugenn14	5	4	microglia	microglia	NN
cord-337365-hugenn14	5	5	in	in	IN
cord-337365-hugenn14	5	6	viral	viral	JJ
cord-337365-hugenn14	5	7	encephalitis	encephalitis	NN
cord-337365-hugenn14	5	8	:	:	:
cord-337365-hugenn14	5	9	a	a	DT
cord-337365-hugenn14	5	10	review	review	NN
cord-337365-hugenn14	5	11	date	date	NN
cord-337365-hugenn14	5	12	:	:	:
cord-337365-hugenn14	5	13	2019	2019	CD
cord-337365-hugenn14	5	14	-	-	HYPH
cord-337365-hugenn14	5	15	04	04	CD
cord-337365-hugenn14	5	16	-	-	HYPH
cord-337365-hugenn14	5	17	09	09	CD
cord-337365-hugenn14	5	18	journal	journal	NN
cord-337365-hugenn14	5	19	:	:	:
cord-337365-hugenn14	5	20	J	J	NNP
cord-337365-hugenn14	5	21	Neuroinflammation	Neuroinflammation	NNP
cord-337365-hugenn14	5	22	DOI	DOI	NNP
cord-337365-hugenn14	5	23	:	:	:
cord-337365-hugenn14	6	1	10.1186	10.1186	CD
cord-337365-hugenn14	6	2	/	/	SYM
cord-337365-hugenn14	6	3	s12974	s12974	CD
cord-337365-hugenn14	6	4	-	-	HYPH
cord-337365-hugenn14	6	5	019	019	CD
cord-337365-hugenn14	6	6	-	-	HYPH
cord-337365-hugenn14	6	7	1443	1443	CD
cord-337365-hugenn14	6	8	-	-	SYM
cord-337365-hugenn14	6	9	2	2	CD
cord-337365-hugenn14	6	10	sha	sha	NN
cord-337365-hugenn14	6	11	:	:	:
cord-337365-hugenn14	7	1	f0384ad1acd95e489c5d835a494de1cdd3fd365f	f0384ad1acd95e489c5d835a494de1cdd3fd365f	NNP
cord-337365-hugenn14	7	2	doc_id	doc_id	NNP
cord-337365-hugenn14	7	3	:	:	:
cord-337365-hugenn14	7	4	337365	337365	CD
cord-337365-hugenn14	7	5	cord_uid	cord_uid	NNS
cord-337365-hugenn14	7	6	:	:	:
cord-337365-hugenn14	8	1	hugenn14	hugenn14	NN
cord-337365-hugenn14	9	1	Viral	viral	JJ
cord-337365-hugenn14	9	2	encephalitis	encephalitis	RB
cord-337365-hugenn14	9	3	is	be	VBZ
cord-337365-hugenn14	9	4	still	still	RB
cord-337365-hugenn14	9	5	very	very	RB
cord-337365-hugenn14	9	6	prominent	prominent	JJ
cord-337365-hugenn14	9	7	around	around	IN
cord-337365-hugenn14	9	8	the	the	DT
cord-337365-hugenn14	9	9	world	world	NN
cord-337365-hugenn14	9	10	,	,	,
cord-337365-hugenn14	9	11	and	and	CC
cord-337365-hugenn14	9	12	traditional	traditional	JJ
cord-337365-hugenn14	9	13	antiviral	antiviral	JJ
cord-337365-hugenn14	9	14	therapies	therapy	NNS
cord-337365-hugenn14	9	15	still	still	RB
cord-337365-hugenn14	9	16	have	have	VBP
cord-337365-hugenn14	9	17	shortcomings	shortcoming	NNS
cord-337365-hugenn14	9	18	.	.	.
cord-337365-hugenn14	10	1	Some	some	DT
cord-337365-hugenn14	10	2	patients	patient	NNS
cord-337365-hugenn14	10	3	can	can	MD
cord-337365-hugenn14	10	4	not	not	RB
cord-337365-hugenn14	10	5	get	get	VB
cord-337365-hugenn14	10	6	effective	effective	JJ
cord-337365-hugenn14	10	7	relief	relief	NN
cord-337365-hugenn14	10	8	or	or	CC
cord-337365-hugenn14	10	9	suffer	suffer	VB
cord-337365-hugenn14	10	10	from	from	IN
cord-337365-hugenn14	10	11	serious	serious	JJ
cord-337365-hugenn14	10	12	sequelae	sequela	NNS
cord-337365-hugenn14	10	13	.	.	.
cord-337365-hugenn14	11	1	At	at	IN
cord-337365-hugenn14	11	2	present	present	JJ
cord-337365-hugenn14	11	3	,	,	,
cord-337365-hugenn14	11	4	people	people	NNS
cord-337365-hugenn14	11	5	are	be	VBP
cord-337365-hugenn14	11	6	studying	study	VBG
cord-337365-hugenn14	11	7	the	the	DT
cord-337365-hugenn14	11	8	role	role	NN
cord-337365-hugenn14	11	9	of	of	IN
cord-337365-hugenn14	11	10	the	the	DT
cord-337365-hugenn14	11	11	innate	innate	JJ
cord-337365-hugenn14	11	12	immune	immune	JJ
cord-337365-hugenn14	11	13	system	system	NN
cord-337365-hugenn14	11	14	in	in	IN
cord-337365-hugenn14	11	15	viral	viral	JJ
cord-337365-hugenn14	11	16	encephalitis	encephalitis	RB
cord-337365-hugenn14	11	17	.	.	.
cord-337365-hugenn14	12	1	Microglia	Microglia	NNP
cord-337365-hugenn14	12	2	,	,	,
cord-337365-hugenn14	12	3	as	as	IN
cord-337365-hugenn14	12	4	resident	resident	JJ
cord-337365-hugenn14	12	5	cells	cell	NNS
cord-337365-hugenn14	12	6	of	of	IN
cord-337365-hugenn14	12	7	the	the	DT
cord-337365-hugenn14	12	8	central	central	JJ
cord-337365-hugenn14	12	9	nervous	nervous	JJ
cord-337365-hugenn14	12	10	system	system	NN
cord-337365-hugenn14	12	11	(	(	-LRB-
cord-337365-hugenn14	12	12	CNS	CNS	NNP
cord-337365-hugenn14	12	13	)	)	-RRB-
cord-337365-hugenn14	12	14	,	,	,
cord-337365-hugenn14	12	15	can	can	MD
cord-337365-hugenn14	12	16	respond	respond	VB
cord-337365-hugenn14	12	17	quickly	quickly	RB
cord-337365-hugenn14	12	18	to	to	IN
cord-337365-hugenn14	12	19	various	various	JJ
cord-337365-hugenn14	12	20	CNS	CNS	NNP
cord-337365-hugenn14	12	21	injuries	injury	NNS
cord-337365-hugenn14	12	22	including	include	VBG
cord-337365-hugenn14	12	23	trauma	trauma	NN
cord-337365-hugenn14	12	24	,	,	,
cord-337365-hugenn14	12	25	ischemia	ischemia	NN
cord-337365-hugenn14	12	26	,	,	,
cord-337365-hugenn14	12	27	and	and	CC
cord-337365-hugenn14	12	28	infection	infection	NN
cord-337365-hugenn14	12	29	and	and	CC
cord-337365-hugenn14	12	30	maintain	maintain	VB
cord-337365-hugenn14	12	31	the	the	DT
cord-337365-hugenn14	12	32	homeostasis	homeostasis	NN
cord-337365-hugenn14	12	33	of	of	IN
cord-337365-hugenn14	12	34	CNS	CNS	NNP
cord-337365-hugenn14	12	35	,	,	,
cord-337365-hugenn14	12	36	but	but	CC
cord-337365-hugenn14	12	37	this	this	DT
cord-337365-hugenn14	12	38	response	response	NN
cord-337365-hugenn14	12	39	is	be	VBZ
cord-337365-hugenn14	12	40	not	not	RB
cord-337365-hugenn14	12	41	always	always	RB
cord-337365-hugenn14	12	42	good	good	JJ
cord-337365-hugenn14	12	43	;	;	:
cord-337365-hugenn14	12	44	sometimes	sometimes	RB
cord-337365-hugenn14	12	45	,	,	,
cord-337365-hugenn14	12	46	it	-PRON-	PRP
cord-337365-hugenn14	12	47	will	will	MD
cord-337365-hugenn14	12	48	exacerbate	exacerbate	VB
cord-337365-hugenn14	12	49	damage	damage	NN
cord-337365-hugenn14	12	50	.	.	.
cord-337365-hugenn14	13	1	Studies	study	NNS
cord-337365-hugenn14	13	2	have	have	VBP
cord-337365-hugenn14	13	3	shown	show	VBN
cord-337365-hugenn14	13	4	that	that	IN
cord-337365-hugenn14	13	5	microglia	microglia	NNS
cord-337365-hugenn14	13	6	also	also	RB
cord-337365-hugenn14	13	7	act	act	VBP
cord-337365-hugenn14	13	8	as	as	IN
cord-337365-hugenn14	13	9	a	a	DT
cord-337365-hugenn14	13	10	double	double	RB
cord-337365-hugenn14	13	11	-	-	HYPH
cord-337365-hugenn14	13	12	edged	edged	JJ
cord-337365-hugenn14	13	13	sword	sword	NN
cord-337365-hugenn14	13	14	during	during	IN
cord-337365-hugenn14	13	15	viral	viral	JJ
cord-337365-hugenn14	13	16	encephalitis	encephalitis	RB
cord-337365-hugenn14	13	17	.	.	.
cord-337365-hugenn14	14	1	On	on	IN
cord-337365-hugenn14	14	2	the	the	DT
cord-337365-hugenn14	14	3	one	one	CD
cord-337365-hugenn14	14	4	hand	hand	NN
cord-337365-hugenn14	14	5	,	,	,
cord-337365-hugenn14	14	6	microglia	microglia	NNP
cord-337365-hugenn14	14	7	can	can	MD
cord-337365-hugenn14	14	8	sense	sense	VB
cord-337365-hugenn14	14	9	ATP	ATP	NNP
cord-337365-hugenn14	14	10	signals	signal	NNS
cord-337365-hugenn14	14	11	through	through	IN
cord-337365-hugenn14	14	12	the	the	DT
cord-337365-hugenn14	14	13	purinergic	purinergic	JJ
cord-337365-hugenn14	14	14	receptor	receptor	NN
cord-337365-hugenn14	14	15	P2Y12	P2Y12	NNP
cord-337365-hugenn14	14	16	and	and	CC
cord-337365-hugenn14	14	17	are	be	VBP
cord-337365-hugenn14	14	18	recruited	recruit	VBN
cord-337365-hugenn14	14	19	around	around	IN
cord-337365-hugenn14	14	20	infected	infected	JJ
cord-337365-hugenn14	14	21	neurons	neuron	NNS
cord-337365-hugenn14	14	22	to	to	TO
cord-337365-hugenn14	14	23	exert	exert	VB
cord-337365-hugenn14	14	24	phagocytic	phagocytic	JJ
cord-337365-hugenn14	14	25	activity	activity	NN
cord-337365-hugenn14	14	26	.	.	.
cord-337365-hugenn14	15	1	Microglia	Microglia	NNP
cord-337365-hugenn14	15	2	can	can	MD
cord-337365-hugenn14	15	3	exert	exert	VB
cord-337365-hugenn14	15	4	a	a	DT
cord-337365-hugenn14	15	5	direct	direct	JJ
cord-337365-hugenn14	15	6	antiviral	antiviral	JJ
cord-337365-hugenn14	15	7	effect	effect	NN
cord-337365-hugenn14	15	8	by	by	IN
cord-337365-hugenn14	15	9	producing	produce	VBG
cord-337365-hugenn14	15	10	type	type	NN
cord-337365-hugenn14	15	11	1	1	CD
cord-337365-hugenn14	16	1	interferon	interferon	NNP
cord-337365-hugenn14	16	2	(	(	-LRB-
cord-337365-hugenn14	16	3	IFN-1	IFN-1	NNP
cord-337365-hugenn14	16	4	)	)	-RRB-
cord-337365-hugenn14	17	1	to	to	TO
cord-337365-hugenn14	17	2	induce	induce	VB
cord-337365-hugenn14	17	3	IFN	IFN	NNP
cord-337365-hugenn14	17	4	-	-	HYPH
cord-337365-hugenn14	17	5	stimulated	stimulate	VBN
cord-337365-hugenn14	17	6	gene	gene	NN
cord-337365-hugenn14	17	7	(	(	-LRB-
cord-337365-hugenn14	17	8	ISG	ISG	NNP
cord-337365-hugenn14	17	9	)	)	-RRB-
cord-337365-hugenn14	17	10	expression	expression	NN
cord-337365-hugenn14	17	11	of	of	IN
cord-337365-hugenn14	17	12	themselves	-PRON-	PRP
cord-337365-hugenn14	17	13	or	or	CC
cord-337365-hugenn14	17	14	indirect	indirect	JJ
cord-337365-hugenn14	17	15	antiviral	antiviral	JJ
cord-337365-hugenn14	17	16	effects	effect	NNS
cord-337365-hugenn14	17	17	by	by	IN
cord-337365-hugenn14	17	18	IFN-1	IFN-1	NNP
cord-337365-hugenn14	17	19	acting	act	VBG
cord-337365-hugenn14	17	20	on	on	IN
cord-337365-hugenn14	17	21	other	other	JJ
cord-337365-hugenn14	17	22	cells	cell	NNS
cord-337365-hugenn14	17	23	to	to	TO
cord-337365-hugenn14	17	24	activate	activate	VB
cord-337365-hugenn14	17	25	corresponding	correspond	VBG
cord-337365-hugenn14	17	26	signaling	signal	VBG
cord-337365-hugenn14	17	27	pathways	pathway	NNS
cord-337365-hugenn14	17	28	.	.	.
cord-337365-hugenn14	18	1	In	in	IN
cord-337365-hugenn14	18	2	addition	addition	NN
cord-337365-hugenn14	18	3	,	,	,
cord-337365-hugenn14	18	4	microglia	microglia	NNP
cord-337365-hugenn14	18	5	can	can	MD
cord-337365-hugenn14	18	6	also	also	RB
cord-337365-hugenn14	18	7	exert	exert	VB
cord-337365-hugenn14	18	8	an	an	DT
cord-337365-hugenn14	18	9	antiviral	antiviral	JJ
cord-337365-hugenn14	18	10	effect	effect	NN
cord-337365-hugenn14	18	11	by	by	IN
cord-337365-hugenn14	18	12	inducing	induce	VBG
cord-337365-hugenn14	18	13	autophagy	autophagy	NN
cord-337365-hugenn14	18	14	or	or	CC
cord-337365-hugenn14	18	15	secreting	secrete	VBG
cord-337365-hugenn14	18	16	cytokines	cytokine	NNS
cord-337365-hugenn14	18	17	.	.	.
cord-337365-hugenn14	19	1	On	on	IN
cord-337365-hugenn14	19	2	the	the	DT
cord-337365-hugenn14	19	3	other	other	JJ
cord-337365-hugenn14	19	4	hand	hand	NN
cord-337365-hugenn14	19	5	,	,	,
cord-337365-hugenn14	19	6	microglia	microglia	NNS
cord-337365-hugenn14	19	7	mediate	mediate	VBP
cord-337365-hugenn14	19	8	presynaptic	presynaptic	JJ
cord-337365-hugenn14	19	9	membrane	membrane	NN
cord-337365-hugenn14	19	10	damage	damage	NN
cord-337365-hugenn14	19	11	in	in	IN
cord-337365-hugenn14	19	12	the	the	DT
cord-337365-hugenn14	19	13	hippocampus	hippocampus	NN
cord-337365-hugenn14	19	14	through	through	IN
cord-337365-hugenn14	19	15	complement	complement	NN
cord-337365-hugenn14	19	16	,	,	,
cord-337365-hugenn14	19	17	resulting	result	VBG
cord-337365-hugenn14	19	18	in	in	IN
cord-337365-hugenn14	19	19	long	long	JJ
cord-337365-hugenn14	19	20	-	-	HYPH
cord-337365-hugenn14	19	21	term	term	NN
cord-337365-hugenn14	19	22	memory	memory	NN
cord-337365-hugenn14	19	23	impairment	impairment	NN
cord-337365-hugenn14	19	24	and	and	CC
cord-337365-hugenn14	19	25	cognitive	cognitive	JJ
cord-337365-hugenn14	19	26	dysfunction	dysfunction	NN
cord-337365-hugenn14	19	27	in	in	IN
cord-337365-hugenn14	19	28	patients	patient	NNS
cord-337365-hugenn14	19	29	with	with	IN
cord-337365-hugenn14	19	30	encephalitis	encephalitis	NN
cord-337365-hugenn14	19	31	.	.	.
cord-337365-hugenn14	20	1	Microglia	Microglia	NNP
cord-337365-hugenn14	20	2	mediate	mediate	VB
cord-337365-hugenn14	20	3	fetal	fetal	JJ
cord-337365-hugenn14	20	4	congenital	congenital	JJ
cord-337365-hugenn14	20	5	malformations	malformation	NNS
cord-337365-hugenn14	20	6	caused	cause	VBN
cord-337365-hugenn14	20	7	by	by	IN
cord-337365-hugenn14	20	8	Zika	Zika	NNP
cord-337365-hugenn14	20	9	virus	virus	NN
cord-337365-hugenn14	20	10	(	(	-LRB-
cord-337365-hugenn14	20	11	ZIKV	zikv	NN
cord-337365-hugenn14	20	12	)	)	-RRB-
cord-337365-hugenn14	20	13	infection	infection	NN
cord-337365-hugenn14	20	14	.	.	.
cord-337365-hugenn14	21	1	The	the	DT
cord-337365-hugenn14	21	2	gene	gene	NN
cord-337365-hugenn14	21	3	expression	expression	NN
cord-337365-hugenn14	21	4	profile	profile	NN
cord-337365-hugenn14	21	5	of	of	IN
cord-337365-hugenn14	21	6	microglia	microglia	NN
cord-337365-hugenn14	21	7	in	in	IN
cord-337365-hugenn14	21	8	HIV	HIV	NNP
cord-337365-hugenn14	21	9	encephalitis	encephalitis	RB
cord-337365-hugenn14	21	10	changes	change	NNS
cord-337365-hugenn14	21	11	,	,	,
cord-337365-hugenn14	21	12	and	and	CC
cord-337365-hugenn14	21	13	they	-PRON-	PRP
cord-337365-hugenn14	21	14	tend	tend	VBP
cord-337365-hugenn14	21	15	to	to	TO
cord-337365-hugenn14	21	16	be	be	VB
cord-337365-hugenn14	21	17	a	a	DT
cord-337365-hugenn14	21	18	pro	pro	JJ
cord-337365-hugenn14	21	19	-	-	JJ
cord-337365-hugenn14	21	20	inflammatory	inflammatory	JJ
cord-337365-hugenn14	21	21	type	type	NN
cord-337365-hugenn14	21	22	.	.	.
cord-337365-hugenn14	22	1	Microglia	Microglia	NNP
cord-337365-hugenn14	22	2	inhibited	inhibit	VBN
cord-337365-hugenn14	22	3	neuronal	neuronal	JJ
cord-337365-hugenn14	22	4	autophagy	autophagy	NN
cord-337365-hugenn14	22	5	and	and	CC
cord-337365-hugenn14	22	6	aggravated	aggravate	VBD
cord-337365-hugenn14	22	7	the	the	DT
cord-337365-hugenn14	22	8	damage	damage	NN
cord-337365-hugenn14	22	9	of	of	IN
cord-337365-hugenn14	22	10	CNS	CNS	NNP
cord-337365-hugenn14	22	11	in	in	IN
cord-337365-hugenn14	22	12	HIV	HIV	NNP
cord-337365-hugenn14	22	13	encephalitis	encephalitis	RB
cord-337365-hugenn14	22	14	;	;	:
cord-337365-hugenn14	22	15	E3	E3	NNP
cord-337365-hugenn14	22	16	ubiquitin	ubiquitin	NN
cord-337365-hugenn14	22	17	ligase	ligase	NN
cord-337365-hugenn14	22	18	Pellino	Pellino	NNP
cord-337365-hugenn14	22	19	(	(	-LRB-
cord-337365-hugenn14	22	20	pelia	pelia	NNP
cord-337365-hugenn14	22	21	)	)	-RRB-
cord-337365-hugenn14	22	22	expressed	express	VBN
cord-337365-hugenn14	22	23	by	by	IN
cord-337365-hugenn14	22	24	microglia	microglia	NNP
cord-337365-hugenn14	22	25	promotes	promote	VBZ
cord-337365-hugenn14	22	26	the	the	DT
cord-337365-hugenn14	22	27	replication	replication	NN
cord-337365-hugenn14	22	28	of	of	IN
cord-337365-hugenn14	22	29	virus	virus	NN
cord-337365-hugenn14	22	30	in	in	IN
cord-337365-hugenn14	22	31	neurons	neuron	NNS
cord-337365-hugenn14	22	32	.	.	.
cord-337365-hugenn14	23	1	The	the	DT
cord-337365-hugenn14	23	2	interaction	interaction	NN
cord-337365-hugenn14	23	3	between	between	IN
cord-337365-hugenn14	23	4	amyloid	amyloid	NN
cord-337365-hugenn14	23	5	-	-	HYPH
cord-337365-hugenn14	23	6	β	β	NN
cord-337365-hugenn14	23	7	peptide	peptide	NN
cord-337365-hugenn14	23	8	(	(	-LRB-
cord-337365-hugenn14	23	9	Aβ	Aβ	NNP
cord-337365-hugenn14	23	10	)	)	-RRB-
cord-337365-hugenn14	23	11	produced	produce	VBN
cord-337365-hugenn14	23	12	by	by	IN
cord-337365-hugenn14	23	13	neurons	neuron	NNS
cord-337365-hugenn14	23	14	and	and	CC
cord-337365-hugenn14	23	15	activated	activate	VBN
cord-337365-hugenn14	23	16	microglia	microglia	NNS
cord-337365-hugenn14	23	17	during	during	IN
cord-337365-hugenn14	23	18	viral	viral	JJ
cord-337365-hugenn14	23	19	infection	infection	NN
cord-337365-hugenn14	23	20	is	be	VBZ
cord-337365-hugenn14	23	21	uncertain	uncertain	JJ
cord-337365-hugenn14	23	22	.	.	.
cord-337365-hugenn14	24	1	Although	although	IN
cord-337365-hugenn14	24	2	neurons	neuron	NNS
cord-337365-hugenn14	24	3	can	can	MD
cord-337365-hugenn14	24	4	mediate	mediate	VB
cord-337365-hugenn14	24	5	antiviral	antiviral	JJ
cord-337365-hugenn14	24	6	effects	effect	NNS
cord-337365-hugenn14	24	7	by	by	IN
cord-337365-hugenn14	24	8	activating	activate	VBG
cord-337365-hugenn14	24	9	receptor	receptor	NN
cord-337365-hugenn14	24	10	-	-	HYPH
cord-337365-hugenn14	24	11	interacting	interact	VBG
cord-337365-hugenn14	24	12	protein	protein	NN
cord-337365-hugenn14	24	13	kinases	kinase	NNS
cord-337365-hugenn14	24	14	3	3	CD
cord-337365-hugenn14	24	15	(	(	-LRB-
cord-337365-hugenn14	24	16	RIPK3	RIPK3	NNP
cord-337365-hugenn14	24	17	)	)	-RRB-
cord-337365-hugenn14	24	18	in	in	IN
cord-337365-hugenn14	24	19	a	a	DT
cord-337365-hugenn14	24	20	death	death	NN
cord-337365-hugenn14	24	21	-	-	HYPH
cord-337365-hugenn14	24	22	independent	independent	JJ
cord-337365-hugenn14	24	23	pathway	pathway	NN
cord-337365-hugenn14	24	24	,	,	,
cord-337365-hugenn14	24	25	the	the	DT
cord-337365-hugenn14	24	26	RIPK3	ripk3	NN
cord-337365-hugenn14	24	27	pathway	pathway	NN
cord-337365-hugenn14	24	28	of	of	IN
cord-337365-hugenn14	24	29	microglia	microglia	NNP
cord-337365-hugenn14	24	30	is	be	VBZ
cord-337365-hugenn14	24	31	unknown	unknown	JJ
cord-337365-hugenn14	24	32	.	.	.
cord-337365-hugenn14	25	1	Different	different	JJ
cord-337365-hugenn14	25	2	brain	brain	NN
cord-337365-hugenn14	25	3	regions	region	NNS
cord-337365-hugenn14	25	4	have	have	VBP
cord-337365-hugenn14	25	5	different	different	JJ
cord-337365-hugenn14	25	6	susceptibility	susceptibility	NN
cord-337365-hugenn14	25	7	to	to	IN
cord-337365-hugenn14	25	8	viruses	virus	NNS
cord-337365-hugenn14	25	9	,	,	,
cord-337365-hugenn14	25	10	and	and	CC
cord-337365-hugenn14	25	11	the	the	DT
cord-337365-hugenn14	25	12	gene	gene	NN
cord-337365-hugenn14	25	13	expression	expression	NN
cord-337365-hugenn14	25	14	of	of	IN
cord-337365-hugenn14	25	15	microglia	microglia	NNS
cord-337365-hugenn14	25	16	in	in	IN
cord-337365-hugenn14	25	17	different	different	JJ
cord-337365-hugenn14	25	18	brain	brain	NN
cord-337365-hugenn14	25	19	regions	region	NNS
cord-337365-hugenn14	25	20	is	be	VBZ
cord-337365-hugenn14	25	21	specific	specific	JJ
cord-337365-hugenn14	25	22	.	.	.
cord-337365-hugenn14	26	1	The	the	DT
cord-337365-hugenn14	26	2	relationship	relationship	NN
cord-337365-hugenn14	26	3	between	between	IN
cord-337365-hugenn14	26	4	the	the	DT
cord-337365-hugenn14	26	5	two	two	CD
cord-337365-hugenn14	26	6	needs	need	NNS
cord-337365-hugenn14	26	7	to	to	TO
cord-337365-hugenn14	26	8	be	be	VB
cord-337365-hugenn14	26	9	further	further	RB
cord-337365-hugenn14	26	10	confirmed	confirm	VBN
cord-337365-hugenn14	26	11	.	.	.
cord-337365-hugenn14	27	1	How	how	WRB
cord-337365-hugenn14	27	2	to	to	TO
cord-337365-hugenn14	27	3	properly	properly	RB
cord-337365-hugenn14	27	4	regulate	regulate	VB
cord-337365-hugenn14	27	5	the	the	DT
cord-337365-hugenn14	27	6	function	function	NN
cord-337365-hugenn14	27	7	of	of	IN
cord-337365-hugenn14	27	8	microglia	microglia	NN
cord-337365-hugenn14	27	9	and	and	CC
cord-337365-hugenn14	27	10	make	make	VB
cord-337365-hugenn14	27	11	it	-PRON-	PRP
cord-337365-hugenn14	27	12	exert	exert	VB
cord-337365-hugenn14	27	13	more	more	RBR
cord-337365-hugenn14	27	14	anti	anti	JJ
cord-337365-hugenn14	27	15	-	-	JJ
cord-337365-hugenn14	27	16	inflammatory	inflammatory	JJ
cord-337365-hugenn14	27	17	effects	effect	NNS
cord-337365-hugenn14	27	18	is	be	VBZ
cord-337365-hugenn14	27	19	our	-PRON-	PRP$
cord-337365-hugenn14	27	20	next	next	JJ
cord-337365-hugenn14	27	21	research	research	NN
cord-337365-hugenn14	27	22	direction	direction	NN
cord-337365-hugenn14	27	23	.	.	.
cord-337365-hugenn14	28	1	Encephalitis	encephalitis	NN
cord-337365-hugenn14	28	2	is	be	VBZ
cord-337365-hugenn14	28	3	a	a	DT
cord-337365-hugenn14	28	4	common	common	JJ
cord-337365-hugenn14	28	5	and	and	CC
cord-337365-hugenn14	28	6	serious	serious	JJ
cord-337365-hugenn14	28	7	disease	disease	NN
cord-337365-hugenn14	28	8	,	,	,
cord-337365-hugenn14	28	9	and	and	CC
cord-337365-hugenn14	28	10	its	-PRON-	PRP$
cord-337365-hugenn14	28	11	clinical	clinical	JJ
cord-337365-hugenn14	28	12	manifestations	manifestation	NNS
cord-337365-hugenn14	28	13	vary	vary	VBP
cord-337365-hugenn14	28	14	from	from	IN
cord-337365-hugenn14	28	15	person	person	NN
cord-337365-hugenn14	28	16	to	to	IN
cord-337365-hugenn14	28	17	person	person	NN
cord-337365-hugenn14	28	18	.	.	.
cord-337365-hugenn14	29	1	Its	-PRON-	PRP$
cord-337365-hugenn14	29	2	main	main	JJ
cord-337365-hugenn14	29	3	characteristics	characteristic	NNS
cord-337365-hugenn14	29	4	include	include	VBP
cord-337365-hugenn14	29	5	altered	alter	VBN
cord-337365-hugenn14	29	6	mental	mental	JJ
cord-337365-hugenn14	29	7	status	status	NN
cord-337365-hugenn14	29	8	and	and	CC
cord-337365-hugenn14	29	9	various	various	JJ
cord-337365-hugenn14	29	10	combinations	combination	NNS
cord-337365-hugenn14	29	11	of	of	IN
cord-337365-hugenn14	29	12	acute	acute	JJ
cord-337365-hugenn14	29	13	fever	fever	NN
cord-337365-hugenn14	29	14	,	,	,
cord-337365-hugenn14	29	15	seizures	seizure	NNS
cord-337365-hugenn14	29	16	,	,	,
cord-337365-hugenn14	29	17	neurologic	neurologic	JJ
cord-337365-hugenn14	29	18	deficits	deficit	NNS
cord-337365-hugenn14	29	19	,	,	,
cord-337365-hugenn14	29	20	cerebrospinal	cerebrospinal	JJ
cord-337365-hugenn14	29	21	fluid	fluid	NN
cord-337365-hugenn14	29	22	(	(	-LRB-
cord-337365-hugenn14	29	23	CSF	CSF	NNP
cord-337365-hugenn14	29	24	)	)	-RRB-
cord-337365-hugenn14	29	25	pleocytosis	pleocytosis	NNP
cord-337365-hugenn14	29	26	,	,	,
cord-337365-hugenn14	29	27	and	and	CC
cord-337365-hugenn14	29	28	abnormalities	abnormality	NNS
cord-337365-hugenn14	29	29	in	in	IN
cord-337365-hugenn14	29	30	electroencephalographic	electroencephalographic	JJ
cord-337365-hugenn14	29	31	(	(	-LRB-
cord-337365-hugenn14	29	32	EEG	EEG	NNP
cord-337365-hugenn14	29	33	)	)	-RRB-
cord-337365-hugenn14	29	34	[	[	-LRB-
cord-337365-hugenn14	29	35	1	1	CD
cord-337365-hugenn14	29	36	]	]	-RRB-
cord-337365-hugenn14	29	37	.	.	.
cord-337365-hugenn14	30	1	Although	although	IN
cord-337365-hugenn14	30	2	there	there	EX
cord-337365-hugenn14	30	3	are	be	VBP
cord-337365-hugenn14	30	4	many	many	JJ
cord-337365-hugenn14	30	5	reasons	reason	NNS
cord-337365-hugenn14	30	6	accounting	account	VBG
cord-337365-hugenn14	30	7	for	for	IN
cord-337365-hugenn14	30	8	this	this	DT
cord-337365-hugenn14	30	9	disease	disease	NN
cord-337365-hugenn14	30	10	,	,	,
cord-337365-hugenn14	30	11	the	the	DT
cord-337365-hugenn14	30	12	most	most	RBS
cord-337365-hugenn14	30	13	commonly	commonly	RB
cord-337365-hugenn14	30	14	identified	identify	VBN
cord-337365-hugenn14	30	15	causes	cause	NNS
cord-337365-hugenn14	30	16	are	be	VBP
cord-337365-hugenn14	30	17	neurotropic	neurotropic	JJ
cord-337365-hugenn14	30	18	viruses	virus	NNS
cord-337365-hugenn14	30	19	.	.	.
cord-337365-hugenn14	31	1	Every	every	DT
cord-337365-hugenn14	31	2	year	year	NN
cord-337365-hugenn14	31	3	in	in	IN
cord-337365-hugenn14	31	4	the	the	DT
cord-337365-hugenn14	31	5	USA	USA	NNP
cord-337365-hugenn14	31	6	,	,	,
cord-337365-hugenn14	31	7	there	there	EX
cord-337365-hugenn14	31	8	are	be	VBP
cord-337365-hugenn14	31	9	about	about	RB
cord-337365-hugenn14	31	10	seven	seven	CD
cord-337365-hugenn14	31	11	patients	patient	NNS
cord-337365-hugenn14	31	12	per	per	IN
cord-337365-hugenn14	31	13	100,000	100,000	CD
cord-337365-hugenn14	31	14	population	population	NN
cord-337365-hugenn14	31	15	diagnosed	diagnose	VBN
cord-337365-hugenn14	31	16	as	as	RB
cord-337365-hugenn14	31	17	encephalitis	encephalitis	RB
cord-337365-hugenn14	31	18	.	.	.
cord-337365-hugenn14	32	1	Among	among	IN
cord-337365-hugenn14	32	2	all	all	PDT
cord-337365-hugenn14	32	3	the	the	DT
cord-337365-hugenn14	32	4	cases	case	NNS
cord-337365-hugenn14	32	5	,	,	,
cord-337365-hugenn14	32	6	approximately	approximately	RB
cord-337365-hugenn14	32	7	half	half	NN
cord-337365-hugenn14	32	8	of	of	IN
cord-337365-hugenn14	32	9	them	-PRON-	PRP
cord-337365-hugenn14	32	10	have	have	VBP
cord-337365-hugenn14	32	11	unknown	unknown	JJ
cord-337365-hugenn14	32	12	reasons	reason	NNS
cord-337365-hugenn14	32	13	.	.	.
cord-337365-hugenn14	33	1	Of	of	IN
cord-337365-hugenn14	33	2	the	the	DT
cord-337365-hugenn14	33	3	cases	case	NNS
cord-337365-hugenn14	33	4	with	with	IN
cord-337365-hugenn14	33	5	a	a	DT
cord-337365-hugenn14	33	6	known	know	VBN
cord-337365-hugenn14	33	7	cause	cause	NN
cord-337365-hugenn14	33	8	,	,	,
cord-337365-hugenn14	33	9	viruses	virus	NNS
cord-337365-hugenn14	33	10	represent	represent	VBP
cord-337365-hugenn14	33	11	20	20	CD
cord-337365-hugenn14	33	12	-	-	SYM
cord-337365-hugenn14	33	13	50	50	CD
cord-337365-hugenn14	33	14	%	%	NN
cord-337365-hugenn14	33	15	.	.	.
cord-337365-hugenn14	34	1	Herpes	Herpes	NNP
cord-337365-hugenn14	34	2	simplex	simplex	NN
cord-337365-hugenn14	34	3	virus	virus	NN
cord-337365-hugenn14	34	4	(	(	-LRB-
cord-337365-hugenn14	34	5	HSV	HSV	NNP
cord-337365-hugenn14	34	6	)	)	-RRB-
cord-337365-hugenn14	34	7	takes	take	VBZ
cord-337365-hugenn14	34	8	up	up	RP
cord-337365-hugenn14	34	9	50	50	CD
cord-337365-hugenn14	34	10	to	to	TO
cord-337365-hugenn14	34	11	75	75	CD
cord-337365-hugenn14	34	12	%	%	NN
cord-337365-hugenn14	34	13	of	of	IN
cord-337365-hugenn14	34	14	identified	identify	VBN
cord-337365-hugenn14	34	15	viral	viral	JJ
cord-337365-hugenn14	34	16	cases	case	NNS
cord-337365-hugenn14	34	17	,	,	,
cord-337365-hugenn14	34	18	with	with	IN
cord-337365-hugenn14	34	19	varicella	varicella	NN
cord-337365-hugenn14	34	20	-	-	HYPH
cord-337365-hugenn14	34	21	zoster	zoster	NN
cord-337365-hugenn14	34	22	virus	virus	NN
cord-337365-hugenn14	34	23	(	(	-LRB-
cord-337365-hugenn14	34	24	VZV	VZV	NNP
cord-337365-hugenn14	34	25	)	)	-RRB-
cord-337365-hugenn14	34	26	,	,	,
cord-337365-hugenn14	34	27	enteroviruses	enteroviruses	NNP
cord-337365-hugenn14	34	28	,	,	,
cord-337365-hugenn14	34	29	and	and	CC
cord-337365-hugenn14	34	30	arboviruses	arboviruses	NNP
cord-337365-hugenn14	34	31	accounting	account	VBG
cord-337365-hugenn14	34	32	for	for	IN
cord-337365-hugenn14	34	33	the	the	DT
cord-337365-hugenn14	34	34	majority	majority	NN
cord-337365-hugenn14	34	35	of	of	IN
cord-337365-hugenn14	34	36	the	the	DT
cord-337365-hugenn14	34	37	remainders	remainder	NNS
cord-337365-hugenn14	34	38	[	[	-LRB-
cord-337365-hugenn14	34	39	2	2	CD
cord-337365-hugenn14	34	40	]	]	-RRB-
cord-337365-hugenn14	34	41	.	.	.
cord-337365-hugenn14	35	1	It	-PRON-	PRP
cord-337365-hugenn14	35	2	is	be	VBZ
cord-337365-hugenn14	35	3	estimated	estimate	VBN
cord-337365-hugenn14	35	4	that	that	IN
cord-337365-hugenn14	35	5	the	the	DT
cord-337365-hugenn14	35	6	median	median	JJ
cord-337365-hugenn14	35	7	hospitalization	hospitalization	NN
cord-337365-hugenn14	35	8	charge	charge	NN
cord-337365-hugenn14	35	9	for	for	IN
cord-337365-hugenn14	35	10	a	a	DT
cord-337365-hugenn14	35	11	patient	patient	NN
cord-337365-hugenn14	35	12	with	with	IN
cord-337365-hugenn14	35	13	viral	viral	JJ
cord-337365-hugenn14	35	14	encephalitis	encephalitis	NN
cord-337365-hugenn14	35	15	is	be	VBZ
cord-337365-hugenn14	35	16	$	$	$
cord-337365-hugenn14	35	17	89,600	89,600	CD
cord-337365-hugenn14	35	18	for	for	IN
cord-337365-hugenn14	35	19	West	West	NNP
cord-337365-hugenn14	35	20	Nile	Nile	NNP
cord-337365-hugenn14	35	21	virus	virus	NN
cord-337365-hugenn14	35	22	encephalitis	encephalitis	NN
cord-337365-hugenn14	35	23	and	and	CC
cord-337365-hugenn14	35	24	$	$	$
cord-337365-hugenn14	35	25	58,000	58,000	CD
cord-337365-hugenn14	35	26	for	for	IN
cord-337365-hugenn14	35	27	HSV	HSV	NNP
cord-337365-hugenn14	35	28	encephalitis	encephalitis	RB
cord-337365-hugenn14	35	29	.	.	.
cord-337365-hugenn14	36	1	Each	each	DT
cord-337365-hugenn14	36	2	year	year	NN
cord-337365-hugenn14	36	3	in	in	IN
cord-337365-hugenn14	36	4	the	the	DT
cord-337365-hugenn14	36	5	USA	USA	NNP
cord-337365-hugenn14	36	6	,	,	,
cord-337365-hugenn14	36	7	approximately	approximately	RB
cord-337365-hugenn14	36	8	6000	6000	CD
cord-337365-hugenn14	36	9	patients	patient	NNS
cord-337365-hugenn14	36	10	are	be	VBP
cord-337365-hugenn14	36	11	hospitalized	hospitalize	VBN
cord-337365-hugenn14	36	12	for	for	IN
cord-337365-hugenn14	36	13	acute	acute	JJ
cord-337365-hugenn14	36	14	viral	viral	JJ
cord-337365-hugenn14	36	15	encephalitis	encephalitis	RB
cord-337365-hugenn14	36	16	.	.	.
cord-337365-hugenn14	37	1	The	the	DT
cord-337365-hugenn14	37	2	total	total	JJ
cord-337365-hugenn14	37	3	annual	annual	JJ
cord-337365-hugenn14	37	4	cost	cost	NN
cord-337365-hugenn14	37	5	is	be	VBZ
cord-337365-hugenn14	37	6	up	up	IN
cord-337365-hugenn14	37	7	to	to	TO
cord-337365-hugenn14	37	8	$	$	$
cord-337365-hugenn14	37	9	350	350	CD
cord-337365-hugenn14	37	10	million	million	CD
cord-337365-hugenn14	37	11	to	to	TO
cord-337365-hugenn14	37	12	$	$	$
cord-337365-hugenn14	37	13	540	540	CD
cord-337365-hugenn14	37	14	million	million	CD
cord-337365-hugenn14	37	15	,	,	,
cord-337365-hugenn14	37	16	without	without	IN
cord-337365-hugenn14	37	17	counting	count	VBG
cord-337365-hugenn14	37	18	the	the	DT
cord-337365-hugenn14	37	19	cost	cost	NN
cord-337365-hugenn14	37	20	of	of	IN
cord-337365-hugenn14	37	21	care	care	NN
cord-337365-hugenn14	37	22	after	after	IN
cord-337365-hugenn14	37	23	discharge	discharge	NN
cord-337365-hugenn14	37	24	,	,	,
cord-337365-hugenn14	37	25	costs	cost	NNS
cord-337365-hugenn14	37	26	for	for	IN
cord-337365-hugenn14	37	27	family	family	NN
cord-337365-hugenn14	37	28	caregivers	caregiver	NNS
cord-337365-hugenn14	37	29	,	,	,
cord-337365-hugenn14	37	30	and	and	CC
cord-337365-hugenn14	37	31	lost	lose	VBD
cord-337365-hugenn14	37	32	earning	earn	VBG
cord-337365-hugenn14	37	33	[	[	-LRB-
cord-337365-hugenn14	37	34	3	3	CD
cord-337365-hugenn14	37	35	]	]	-RRB-
cord-337365-hugenn14	37	36	.	.	.
cord-337365-hugenn14	38	1	Microglia	Microglia	NNP
cord-337365-hugenn14	38	2	are	be	VBP
cord-337365-hugenn14	38	3	CNS	CNS	NNP
cord-337365-hugenn14	38	4	-	-	HYPH
cord-337365-hugenn14	38	5	resident	resident	JJ
cord-337365-hugenn14	38	6	mononuclear	mononuclear	JJ
cord-337365-hugenn14	38	7	phagocytic	phagocytic	JJ
cord-337365-hugenn14	38	8	cells	cell	NNS
cord-337365-hugenn14	38	9	characterized	characterize	VBN
cord-337365-hugenn14	38	10	by	by	IN
cord-337365-hugenn14	38	11	a	a	DT
cord-337365-hugenn14	38	12	unique	unique	JJ
cord-337365-hugenn14	38	13	ramified	ramified	JJ
cord-337365-hugenn14	38	14	shape	shape	NN
cord-337365-hugenn14	38	15	and	and	CC
cord-337365-hugenn14	38	16	distinctive	distinctive	JJ
cord-337365-hugenn14	38	17	gene	gene	NN
cord-337365-hugenn14	38	18	expression	expression	NN
cord-337365-hugenn14	38	19	[	[	-LRB-
cord-337365-hugenn14	38	20	4	4	CD
cord-337365-hugenn14	38	21	]	]	-RRB-
cord-337365-hugenn14	38	22	.	.	.
cord-337365-hugenn14	39	1	Most	Most	JJS
cord-337365-hugenn14	39	2	microglia	microglia	NNS
cord-337365-hugenn14	39	3	are	be	VBP
cord-337365-hugenn14	39	4	derived	derive	VBN
cord-337365-hugenn14	39	5	from	from	IN
cord-337365-hugenn14	39	6	a	a	DT
cord-337365-hugenn14	39	7	yolk	yolk	NN
cord-337365-hugenn14	39	8	sac	sac	NN
cord-337365-hugenn14	39	9	progenitor	progenitor	NN
cord-337365-hugenn14	39	10	and	and	CC
cord-337365-hugenn14	39	11	seed	seed	VB
cord-337365-hugenn14	39	12	the	the	DT
cord-337365-hugenn14	39	13	brain	brain	NN
cord-337365-hugenn14	39	14	early	early	RB
cord-337365-hugenn14	39	15	in	in	IN
cord-337365-hugenn14	39	16	development	development	NN
cord-337365-hugenn14	39	17	[	[	-LRB-
cord-337365-hugenn14	39	18	5	5	CD
cord-337365-hugenn14	39	19	]	]	-RRB-
cord-337365-hugenn14	39	20	.	.	.
cord-337365-hugenn14	40	1	As	as	IN
cord-337365-hugenn14	40	2	resident	resident	JJ
cord-337365-hugenn14	40	3	cells	cell	NNS
cord-337365-hugenn14	40	4	,	,	,
cord-337365-hugenn14	40	5	microglia	microglia	NNS
cord-337365-hugenn14	40	6	are	be	VBP
cord-337365-hugenn14	40	7	assumed	assume	VBN
cord-337365-hugenn14	40	8	to	to	TO
cord-337365-hugenn14	40	9	help	help	VB
cord-337365-hugenn14	40	10	orchestrate	orchestrate	VB
cord-337365-hugenn14	40	11	the	the	DT
cord-337365-hugenn14	40	12	immune	immune	JJ
cord-337365-hugenn14	40	13	response	response	NN
cord-337365-hugenn14	40	14	to	to	IN
cord-337365-hugenn14	40	15	pathogen	pathogen	NN
cord-337365-hugenn14	40	16	infection	infection	NN
cord-337365-hugenn14	40	17	of	of	IN
cord-337365-hugenn14	40	18	the	the	DT
cord-337365-hugenn14	40	19	brain	brain	NN
cord-337365-hugenn14	40	20	.	.	.
cord-337365-hugenn14	41	1	While	while	IN
cord-337365-hugenn14	41	2	often	often	RB
cord-337365-hugenn14	41	3	touted	tout	VBN
cord-337365-hugenn14	41	4	as	as	IN
cord-337365-hugenn14	41	5	immune	immune	JJ
cord-337365-hugenn14	41	6	sentinels	sentinel	NNS
cord-337365-hugenn14	41	7	,	,	,
cord-337365-hugenn14	41	8	little	little	JJ
cord-337365-hugenn14	41	9	is	be	VBZ
cord-337365-hugenn14	41	10	known	know	VBN
cord-337365-hugenn14	41	11	about	about	IN
cord-337365-hugenn14	41	12	how	how	WRB
cord-337365-hugenn14	41	13	or	or	CC
cord-337365-hugenn14	41	14	if	if	IN
cord-337365-hugenn14	41	15	microglia	microglia	NNS
cord-337365-hugenn14	41	16	engage	engage	VBP
cord-337365-hugenn14	41	17	in	in	IN
cord-337365-hugenn14	41	18	this	this	DT
cord-337365-hugenn14	41	19	function	function	NN
cord-337365-hugenn14	41	20	[	[	-LRB-
cord-337365-hugenn14	41	21	6	6	CD
cord-337365-hugenn14	41	22	]	]	-RRB-
cord-337365-hugenn14	41	23	.	.	.
cord-337365-hugenn14	42	1	So	so	RB
cord-337365-hugenn14	42	2	far	far	RB
cord-337365-hugenn14	42	3	,	,	,
cord-337365-hugenn14	42	4	a	a	DT
cord-337365-hugenn14	42	5	large	large	JJ
cord-337365-hugenn14	42	6	body	body	NN
cord-337365-hugenn14	42	7	of	of	IN
cord-337365-hugenn14	42	8	evidence	evidence	NN
cord-337365-hugenn14	42	9	stemming	stem	VBG
cord-337365-hugenn14	42	10	from	from	IN
cord-337365-hugenn14	42	11	both	both	DT
cord-337365-hugenn14	42	12	in	in	IN
cord-337365-hugenn14	42	13	vitro	vitro	FW
cord-337365-hugenn14	42	14	and	and	CC
cord-337365-hugenn14	42	15	in	in	IN
cord-337365-hugenn14	42	16	vivo	vivo	NNP
cord-337365-hugenn14	42	17	studies	study	NNS
cord-337365-hugenn14	42	18	have	have	VBP
cord-337365-hugenn14	42	19	indicated	indicate	VBN
cord-337365-hugenn14	42	20	that	that	IN
cord-337365-hugenn14	42	21	microglia	microglia	NNS
cord-337365-hugenn14	42	22	are	be	VBP
cord-337365-hugenn14	42	23	capable	capable	JJ
cord-337365-hugenn14	42	24	of	of	IN
cord-337365-hugenn14	42	25	responding	respond	VBG
cord-337365-hugenn14	42	26	to	to	IN
cord-337365-hugenn14	42	27	viral	viral	JJ
cord-337365-hugenn14	42	28	PAMPs	pamp	NNS
cord-337365-hugenn14	42	29	[	[	-LRB-
cord-337365-hugenn14	42	30	7	7	CD
cord-337365-hugenn14	42	31	,	,	,
cord-337365-hugenn14	42	32	8	8	CD
cord-337365-hugenn14	42	33	]	]	-RRB-
cord-337365-hugenn14	42	34	,	,	,
cord-337365-hugenn14	42	35	but	but	CC
cord-337365-hugenn14	42	36	the	the	DT
cord-337365-hugenn14	42	37	multifaceted	multifaceted	JJ
cord-337365-hugenn14	42	38	function	function	NN
cord-337365-hugenn14	42	39	of	of	IN
cord-337365-hugenn14	42	40	microglia	microglia	NNS
cord-337365-hugenn14	42	41	involved	involve	VBN
cord-337365-hugenn14	42	42	in	in	IN
cord-337365-hugenn14	42	43	viral	viral	JJ
cord-337365-hugenn14	42	44	encephalitis	encephalitis	NN
cord-337365-hugenn14	42	45	needs	need	VBZ
cord-337365-hugenn14	42	46	further	further	JJ
cord-337365-hugenn14	42	47	understanding	understanding	NN
cord-337365-hugenn14	42	48	.	.	.
cord-337365-hugenn14	43	1	Recently	recently	RB
cord-337365-hugenn14	43	2	,	,	,
cord-337365-hugenn14	43	3	how	how	WRB
cord-337365-hugenn14	43	4	microglia	microglia	NNS
cord-337365-hugenn14	43	5	are	be	VBP
cord-337365-hugenn14	43	6	recruited	recruit	VBN
cord-337365-hugenn14	43	7	around	around	IN
cord-337365-hugenn14	43	8	infected	infected	JJ
cord-337365-hugenn14	43	9	neurons	neuron	NNS
cord-337365-hugenn14	43	10	and	and	CC
cord-337365-hugenn14	43	11	the	the	DT
cord-337365-hugenn14	43	12	interaction	interaction	NN
cord-337365-hugenn14	43	13	between	between	IN
cord-337365-hugenn14	43	14	microglia	microglia	NNS
cord-337365-hugenn14	43	15	and	and	CC
cord-337365-hugenn14	43	16	other	other	JJ
cord-337365-hugenn14	43	17	cells	cell	NNS
cord-337365-hugenn14	43	18	has	have	VBZ
cord-337365-hugenn14	43	19	become	become	VBN
cord-337365-hugenn14	43	20	a	a	DT
cord-337365-hugenn14	43	21	hot	hot	JJ
cord-337365-hugenn14	43	22	topic	topic	NN
cord-337365-hugenn14	43	23	.	.	.
cord-337365-hugenn14	44	1	In	in	IN
cord-337365-hugenn14	44	2	this	this	DT
cord-337365-hugenn14	44	3	review	review	NN
cord-337365-hugenn14	44	4	,	,	,
cord-337365-hugenn14	44	5	we	-PRON-	PRP
cord-337365-hugenn14	44	6	will	will	MD
cord-337365-hugenn14	44	7	talk	talk	VB
cord-337365-hugenn14	44	8	about	about	IN
cord-337365-hugenn14	44	9	the	the	DT
cord-337365-hugenn14	44	10	function	function	NN
cord-337365-hugenn14	44	11	of	of	IN
cord-337365-hugenn14	44	12	microglia	microglia	NNS
cord-337365-hugenn14	44	13	in	in	IN
cord-337365-hugenn14	44	14	viral	viral	JJ
cord-337365-hugenn14	44	15	encephalitis	encephalitis	RB
cord-337365-hugenn14	44	16	.	.	.
cord-337365-hugenn14	45	1	Microglia	Microglia	NNP
cord-337365-hugenn14	45	2	are	be	VBP
cord-337365-hugenn14	45	3	recruited	recruit	VBN
cord-337365-hugenn14	45	4	around	around	IN
cord-337365-hugenn14	45	5	the	the	DT
cord-337365-hugenn14	45	6	infected	infected	JJ
cord-337365-hugenn14	45	7	neurons	neuron	NNS
cord-337365-hugenn14	45	8	by	by	IN
cord-337365-hugenn14	45	9	sensing	sense	VBG
cord-337365-hugenn14	45	10	extracellular	extracellular	JJ
cord-337365-hugenn14	45	11	ATP	ATP	NNP
cord-337365-hugenn14	45	12	signals	signal	NNS
cord-337365-hugenn14	46	1	Microglia	Microglia	NNP
cord-337365-hugenn14	46	2	can	can	MD
cord-337365-hugenn14	46	3	sense	sense	VB
cord-337365-hugenn14	46	4	the	the	DT
cord-337365-hugenn14	46	5	nucleotides	nucleotide	NNS
cord-337365-hugenn14	46	6	released	release	VBN
cord-337365-hugenn14	46	7	by	by	IN
cord-337365-hugenn14	46	8	infected	infected	JJ
cord-337365-hugenn14	46	9	neurons	neuron	NNS
cord-337365-hugenn14	46	10	and	and	CC
cord-337365-hugenn14	46	11	are	be	VBP
cord-337365-hugenn14	46	12	rapidly	rapidly	RB
cord-337365-hugenn14	46	13	recruited	recruit	VBN
cord-337365-hugenn14	46	14	around	around	IN
cord-337365-hugenn14	46	15	infected	infected	JJ
cord-337365-hugenn14	46	16	neurons	neuron	NNS
cord-337365-hugenn14	46	17	to	to	TO
cord-337365-hugenn14	46	18	exert	exert	VB
cord-337365-hugenn14	46	19	phagocytic	phagocytic	JJ
cord-337365-hugenn14	46	20	activities	activity	NNS
cord-337365-hugenn14	46	21	in	in	IN
cord-337365-hugenn14	46	22	the	the	DT
cord-337365-hugenn14	46	23	brain	brain	NN
cord-337365-hugenn14	46	24	(	(	-LRB-
cord-337365-hugenn14	46	25	see	see	VB
cord-337365-hugenn14	46	26	Fig	Fig	NNP
cord-337365-hugenn14	46	27	.	.	NNP
cord-337365-hugenn14	46	28	1	1	CD
cord-337365-hugenn14	46	29	)	)	-RRB-
cord-337365-hugenn14	46	30	.	.	.
cord-337365-hugenn14	47	1	Neurons	neuron	NNS
cord-337365-hugenn14	47	2	release	release	VBP
cord-337365-hugenn14	47	3	more	more	JJR
cord-337365-hugenn14	47	4	ATP	ATP	NNP
cord-337365-hugenn14	47	5	after	after	IN
cord-337365-hugenn14	47	6	viral	viral	JJ
cord-337365-hugenn14	47	7	infection	infection	NN
cord-337365-hugenn14	47	8	,	,	,
cord-337365-hugenn14	47	9	while	while	IN
cord-337365-hugenn14	47	10	the	the	DT
cord-337365-hugenn14	47	11	levels	level	NNS
cord-337365-hugenn14	47	12	of	of	IN
cord-337365-hugenn14	47	13	ATP	ATP	NNP
cord-337365-hugenn14	47	14	,	,	,
cord-337365-hugenn14	47	15	ADP	ADP	NNP
cord-337365-hugenn14	47	16	,	,	,
cord-337365-hugenn14	47	17	AMP	AMP	NNP
cord-337365-hugenn14	47	18	,	,	,
cord-337365-hugenn14	47	19	and	and	CC
cord-337365-hugenn14	47	20	adenosine	adenosine	NN
cord-337365-hugenn14	47	21	in	in	IN
cord-337365-hugenn14	47	22	cell	cell	NN
cord-337365-hugenn14	47	23	lysates	lysate	NNS
cord-337365-hugenn14	47	24	decrease	decrease	NN
cord-337365-hugenn14	47	25	.	.	.
cord-337365-hugenn14	48	1	Noxious	noxious	JJ
cord-337365-hugenn14	48	2	stimuli	stimulus	NNS
cord-337365-hugenn14	48	3	in	in	IN
cord-337365-hugenn14	48	4	neurons	neuron	NNS
cord-337365-hugenn14	48	5	trigger	trigger	VBP
cord-337365-hugenn14	48	6	a	a	DT
cord-337365-hugenn14	48	7	sustained	sustained	JJ
cord-337365-hugenn14	48	8	increase	increase	NN
cord-337365-hugenn14	48	9	in	in	IN
cord-337365-hugenn14	48	10	extracellular	extracellular	JJ
cord-337365-hugenn14	48	11	ATP	ATP	NNP
cord-337365-hugenn14	48	12	,	,	,
cord-337365-hugenn14	48	13	which	which	WDT
cord-337365-hugenn14	48	14	causes	cause	VBZ
cord-337365-hugenn14	48	15	microglia	microglia	NN
cord-337365-hugenn14	48	16	to	to	TO
cord-337365-hugenn14	48	17	become	become	VB
cord-337365-hugenn14	48	18	activated	activate	VBN
cord-337365-hugenn14	48	19	and	and	CC
cord-337365-hugenn14	48	20	recruited	recruit	VBN
cord-337365-hugenn14	48	21	in	in	IN
cord-337365-hugenn14	48	22	minutes	minute	NNS
cord-337365-hugenn14	48	23	to	to	IN
cord-337365-hugenn14	48	24	hours	hour	NNS
cord-337365-hugenn14	48	25	[	[	-LRB-
cord-337365-hugenn14	48	26	9	9	CD
cord-337365-hugenn14	48	27	]	]	-RRB-
cord-337365-hugenn14	48	28	.	.	.
cord-337365-hugenn14	49	1	ATP	ATP	NNP
cord-337365-hugenn14	49	2	is	be	VBZ
cord-337365-hugenn14	49	3	a	a	DT
cord-337365-hugenn14	49	4	potent	potent	JJ
cord-337365-hugenn14	49	5	agonist	agonist	NN
cord-337365-hugenn14	49	6	of	of	IN
cord-337365-hugenn14	49	7	the	the	DT
cord-337365-hugenn14	49	8	P2Y	p2y	NN
cord-337365-hugenn14	49	9	G	g	NN
cord-337365-hugenn14	49	10	protein	protein	NN
cord-337365-hugenn14	49	11	-	-	HYPH
cord-337365-hugenn14	49	12	coupled	couple	VBN
cord-337365-hugenn14	49	13	receptor	receptor	NN
cord-337365-hugenn14	49	14	[	[	-LRB-
cord-337365-hugenn14	49	15	10	10	CD
cord-337365-hugenn14	49	16	]	]	-RRB-
cord-337365-hugenn14	49	17	.	.	.
cord-337365-hugenn14	50	1	Studies	study	NNS
cord-337365-hugenn14	50	2	have	have	VBP
cord-337365-hugenn14	50	3	shown	show	VBN
cord-337365-hugenn14	50	4	that	that	IN
cord-337365-hugenn14	50	5	P2X7	P2X7	NNP
cord-337365-hugenn14	50	6	or	or	CC
cord-337365-hugenn14	50	7	P2Y12	P2Y12	NNS
cord-337365-hugenn14	50	8	are	be	VBP
cord-337365-hugenn14	50	9	both	both	DT
cord-337365-hugenn14	50	10	abundant	abundant	JJ
cord-337365-hugenn14	50	11	in	in	IN
cord-337365-hugenn14	50	12	microglia	microglia	NN
cord-337365-hugenn14	50	13	,	,	,
cord-337365-hugenn14	50	14	and	and	CC
cord-337365-hugenn14	50	15	P2Y12	P2Y12	NNP
cord-337365-hugenn14	50	16	is	be	VBZ
cord-337365-hugenn14	50	17	a	a	DT
cord-337365-hugenn14	50	18	microglia	microglia	NN
cord-337365-hugenn14	50	19	-	-	HYPH
cord-337365-hugenn14	50	20	specific	specific	JJ
cord-337365-hugenn14	50	21	marker	marker	NN
cord-337365-hugenn14	50	22	in	in	IN
cord-337365-hugenn14	50	23	the	the	DT
cord-337365-hugenn14	50	24	brain	brain	NN
cord-337365-hugenn14	50	25	[	[	-LRB-
cord-337365-hugenn14	50	26	11	11	CD
cord-337365-hugenn14	50	27	]	]	-RRB-
cord-337365-hugenn14	50	28	.	.	.
cord-337365-hugenn14	51	1	Extracellular	Extracellular	NNP
cord-337365-hugenn14	51	2	ATP	ATP	NNP
cord-337365-hugenn14	51	3	is	be	VBZ
cord-337365-hugenn14	51	4	a	a	DT
cord-337365-hugenn14	51	5	strong	strong	JJ
cord-337365-hugenn14	51	6	chemotactic	chemotactic	JJ
cord-337365-hugenn14	51	7	signal	signal	NN
cord-337365-hugenn14	51	8	for	for	IN
cord-337365-hugenn14	51	9	microglia	microglia	NNP
cord-337365-hugenn14	51	10	.	.	.
cord-337365-hugenn14	52	1	By	by	IN
cord-337365-hugenn14	52	2	stimulating	stimulate	VBG
cord-337365-hugenn14	52	3	the	the	DT
cord-337365-hugenn14	52	4	P2Y	p2y	NN
cord-337365-hugenn14	52	5	receptor	receptor	NN
cord-337365-hugenn14	52	6	of	of	IN
cord-337365-hugenn14	52	7	microglia	microglia	NNP
cord-337365-hugenn14	52	8	,	,	,
cord-337365-hugenn14	52	9	Fig	Fig	NNP
cord-337365-hugenn14	52	10	.	.	.
cord-337365-hugenn14	53	1	1	1	CD
cord-337365-hugenn14	53	2	Illustration	illustration	NN
cord-337365-hugenn14	53	3	of	of	IN
cord-337365-hugenn14	53	4	the	the	DT
cord-337365-hugenn14	53	5	anti	anti	JJ
cord-337365-hugenn14	53	6	-	-	JJ
cord-337365-hugenn14	53	7	inflammatory	inflammatory	JJ
cord-337365-hugenn14	53	8	role	role	NN
cord-337365-hugenn14	53	9	of	of	IN
cord-337365-hugenn14	53	10	microglia	microglia	NN
cord-337365-hugenn14	53	11	in	in	IN
cord-337365-hugenn14	53	12	viral	viral	JJ
cord-337365-hugenn14	53	13	encephalitis	encephalitis	RB
cord-337365-hugenn14	53	14	.	.	.
cord-337365-hugenn14	54	1	The	the	DT
cord-337365-hugenn14	54	2	picture	picture	NN
cord-337365-hugenn14	54	3	shows	show	VBZ
cord-337365-hugenn14	54	4	that	that	IN
cord-337365-hugenn14	54	5	microglia	microglia	NNS
cord-337365-hugenn14	54	6	can	can	MD
cord-337365-hugenn14	54	7	sense	sense	VB
cord-337365-hugenn14	54	8	ATP	ATP	NNP
cord-337365-hugenn14	54	9	signals	signal	NNS
cord-337365-hugenn14	54	10	through	through	IN
cord-337365-hugenn14	54	11	the	the	DT
cord-337365-hugenn14	54	12	purinergic	purinergic	JJ
cord-337365-hugenn14	54	13	receptor	receptor	NN
cord-337365-hugenn14	54	14	P2Y12	P2Y12	NNP
cord-337365-hugenn14	54	15	and	and	CC
cord-337365-hugenn14	54	16	are	be	VBP
cord-337365-hugenn14	54	17	recruited	recruit	VBN
cord-337365-hugenn14	54	18	around	around	IN
cord-337365-hugenn14	54	19	infected	infected	JJ
cord-337365-hugenn14	54	20	neurons	neuron	NNS
cord-337365-hugenn14	54	21	to	to	TO
cord-337365-hugenn14	54	22	exert	exert	VB
cord-337365-hugenn14	54	23	phagocytic	phagocytic	JJ
cord-337365-hugenn14	54	24	activity	activity	NN
cord-337365-hugenn14	54	25	.	.	.
cord-337365-hugenn14	55	1	Microglia	Microglia	NNP
cord-337365-hugenn14	55	2	can	can	MD
cord-337365-hugenn14	55	3	exert	exert	VB
cord-337365-hugenn14	55	4	a	a	DT
cord-337365-hugenn14	55	5	direct	direct	JJ
cord-337365-hugenn14	55	6	antiviral	antiviral	JJ
cord-337365-hugenn14	55	7	effect	effect	NN
cord-337365-hugenn14	55	8	by	by	IN
cord-337365-hugenn14	55	9	producing	produce	VBG
cord-337365-hugenn14	55	10	type	type	NN
cord-337365-hugenn14	55	11	1	1	CD
cord-337365-hugenn14	56	1	interferon	interferon	NNP
cord-337365-hugenn14	56	2	(	(	-LRB-
cord-337365-hugenn14	56	3	IFN-1	IFN-1	NNP
cord-337365-hugenn14	56	4	)	)	-RRB-
cord-337365-hugenn14	57	1	to	to	TO
cord-337365-hugenn14	57	2	induce	induce	VB
cord-337365-hugenn14	57	3	IFN	IFN	NNP
cord-337365-hugenn14	57	4	-	-	HYPH
cord-337365-hugenn14	57	5	stimulated	stimulate	VBN
cord-337365-hugenn14	57	6	gene	gene	NN
cord-337365-hugenn14	57	7	(	(	-LRB-
cord-337365-hugenn14	57	8	ISG	ISG	NNP
cord-337365-hugenn14	57	9	)	)	-RRB-
cord-337365-hugenn14	57	10	expression	expression	NN
cord-337365-hugenn14	57	11	of	of	IN
cord-337365-hugenn14	57	12	themselves	-PRON-	PRP
cord-337365-hugenn14	57	13	.	.	.
cord-337365-hugenn14	58	1	IFN	IFN	NNP
cord-337365-hugenn14	58	2	produced	produce	VBN
cord-337365-hugenn14	58	3	by	by	IN
cord-337365-hugenn14	58	4	microglia	microglia	NNP
cord-337365-hugenn14	58	5	exects	exects	NNP
cord-337365-hugenn14	58	6	indirect	indirect	JJ
cord-337365-hugenn14	58	7	antiviral	antiviral	JJ
cord-337365-hugenn14	58	8	effects	effect	NNS
cord-337365-hugenn14	58	9	by	by	IN
cord-337365-hugenn14	58	10	acting	act	VBG
cord-337365-hugenn14	58	11	on	on	IN
cord-337365-hugenn14	58	12	other	other	JJ
cord-337365-hugenn14	58	13	cells	cell	NNS
cord-337365-hugenn14	58	14	to	to	TO
cord-337365-hugenn14	58	15	activate	activate	VB
cord-337365-hugenn14	58	16	corresponding	correspond	VBG
cord-337365-hugenn14	58	17	signaling	signal	VBG
cord-337365-hugenn14	58	18	pathways	pathway	NNS
cord-337365-hugenn14	58	19	it	-PRON-	PRP
cord-337365-hugenn14	58	20	mediates	mediate	VBZ
cord-337365-hugenn14	58	21	the	the	DT
cord-337365-hugenn14	58	22	rapid	rapid	JJ
cord-337365-hugenn14	58	23	response	response	NN
cord-337365-hugenn14	58	24	of	of	IN
cord-337365-hugenn14	58	25	microglia	microglia	NNP
cord-337365-hugenn14	58	26	to	to	IN
cord-337365-hugenn14	58	27	the	the	DT
cord-337365-hugenn14	58	28	injury	injury	NN
cord-337365-hugenn14	58	29	site	site	NN
cord-337365-hugenn14	58	30	[	[	-LRB-
cord-337365-hugenn14	58	31	12	12	CD
cord-337365-hugenn14	58	32	]	]	-RRB-
cord-337365-hugenn14	58	33	.	.	.
cord-337365-hugenn14	59	1	The	the	DT
cord-337365-hugenn14	59	2	number	number	NN
cord-337365-hugenn14	59	3	of	of	IN
cord-337365-hugenn14	59	4	P2Y12	P2Y12	NNP
cord-337365-hugenn14	59	5	receptors	receptor	NNS
cord-337365-hugenn14	59	6	on	on	IN
cord-337365-hugenn14	59	7	the	the	DT
cord-337365-hugenn14	59	8	surface	surface	NN
cord-337365-hugenn14	59	9	of	of	IN
cord-337365-hugenn14	59	10	microglia	microglia	NN
cord-337365-hugenn14	59	11	increased	increase	VBD
cord-337365-hugenn14	59	12	over	over	IN
cord-337365-hugenn14	59	13	twofold	twofold	RB
cord-337365-hugenn14	59	14	in	in	IN
cord-337365-hugenn14	59	15	response	response	NN
cord-337365-hugenn14	59	16	to	to	IN
cord-337365-hugenn14	59	17	viral	viral	JJ
cord-337365-hugenn14	59	18	infections	infection	NNS
cord-337365-hugenn14	59	19	.	.	.
cord-337365-hugenn14	60	1	Some	some	DT
cord-337365-hugenn14	60	2	experiments	experiment	NNS
cord-337365-hugenn14	60	3	have	have	VBP
cord-337365-hugenn14	60	4	built	build	VBN
cord-337365-hugenn14	60	5	a	a	DT
cord-337365-hugenn14	60	6	P2X7-or	P2X7-or	NNP
cord-337365-hugenn14	60	7	P2Y12-deficient	P2Y12-deficient	NNP
cord-337365-hugenn14	60	8	mice	mice	NN
cord-337365-hugenn14	60	9	model	model	NN
cord-337365-hugenn14	60	10	(	(	-LRB-
cord-337365-hugenn14	60	11	P2X7	P2X7	NNP
cord-337365-hugenn14	60	12	−/−	−/−	NNP
cord-337365-hugenn14	60	13	or	or	CC
cord-337365-hugenn14	60	14	P2Y12	P2Y12	NNP
cord-337365-hugenn14	60	15	−/−	−/−	NNP
cord-337365-hugenn14	60	16	)	)	-RRB-
cord-337365-hugenn14	60	17	in	in	IN
cord-337365-hugenn14	60	18	vivo	vivo	NNP
cord-337365-hugenn14	60	19	,	,	,
cord-337365-hugenn14	60	20	the	the	DT
cord-337365-hugenn14	60	21	lack	lack	NN
cord-337365-hugenn14	60	22	of	of	IN
cord-337365-hugenn14	60	23	P2X7	P2X7	NNP
cord-337365-hugenn14	60	24	has	have	VBZ
cord-337365-hugenn14	60	25	no	no	DT
cord-337365-hugenn14	60	26	effect	effect	NN
cord-337365-hugenn14	60	27	on	on	IN
cord-337365-hugenn14	60	28	the	the	DT
cord-337365-hugenn14	60	29	recruitment	recruitment	NN
cord-337365-hugenn14	60	30	of	of	IN
cord-337365-hugenn14	60	31	microglia	microglia	NNP
cord-337365-hugenn14	60	32	,	,	,
cord-337365-hugenn14	60	33	whereas	whereas	IN
cord-337365-hugenn14	60	34	an	an	DT
cord-337365-hugenn14	60	35	absence	absence	NN
cord-337365-hugenn14	60	36	of	of	IN
cord-337365-hugenn14	60	37	P2Y12	P2Y12	NNP
cord-337365-hugenn14	60	38	resulted	result	VBD
cord-337365-hugenn14	60	39	in	in	IN
cord-337365-hugenn14	60	40	>	>	XX
cord-337365-hugenn14	60	41	50	50	CD
cord-337365-hugenn14	60	42	%	%	NN
cord-337365-hugenn14	60	43	reduction	reduction	NN
cord-337365-hugenn14	60	44	in	in	IN
cord-337365-hugenn14	60	45	the	the	DT
cord-337365-hugenn14	60	46	numbers	number	NNS
cord-337365-hugenn14	60	47	of	of	IN
cord-337365-hugenn14	60	48	microglia	microglia	NNS
cord-337365-hugenn14	60	49	recruited	recruit	VBN
cord-337365-hugenn14	60	50	to	to	IN
cord-337365-hugenn14	60	51	infected	infected	JJ
cord-337365-hugenn14	60	52	neurons	neuron	NNS
cord-337365-hugenn14	60	53	.	.	.
cord-337365-hugenn14	61	1	This	this	DT
cord-337365-hugenn14	61	2	indicates	indicate	VBZ
cord-337365-hugenn14	61	3	that	that	IN
cord-337365-hugenn14	61	4	microglia	microglia	NNS
cord-337365-hugenn14	61	5	are	be	VBP
cord-337365-hugenn14	61	6	recruited	recruit	VBN
cord-337365-hugenn14	61	7	around	around	IN
cord-337365-hugenn14	61	8	the	the	DT
cord-337365-hugenn14	61	9	infected	infected	JJ
cord-337365-hugenn14	61	10	neurons	neuron	NNS
cord-337365-hugenn14	61	11	via	via	IN
cord-337365-hugenn14	61	12	P2Y12	P2Y12	NNS
cord-337365-hugenn14	61	13	signaling	signal	VBG
cord-337365-hugenn14	61	14	.	.	.
cord-337365-hugenn14	62	1	The	the	DT
cord-337365-hugenn14	62	2	CD86	CD86	NNP
cord-337365-hugenn14	62	3	+	+	CC
cord-337365-hugenn14	62	4	phagolysosomes	phagolysosome	NNS
cord-337365-hugenn14	62	5	of	of	IN
cord-337365-hugenn14	62	6	P2Y12	P2Y12	NNP
cord-337365-hugenn14	62	7	−/−	−/−	NNP
cord-337365-hugenn14	62	8	microglia	microglia	NNS
cord-337365-hugenn14	62	9	decreased	decrease	VBD
cord-337365-hugenn14	62	10	significantly	significantly	RB
cord-337365-hugenn14	62	11	compared	compare	VBN
cord-337365-hugenn14	62	12	with	with	IN
cord-337365-hugenn14	62	13	normal	normal	JJ
cord-337365-hugenn14	62	14	mice	mouse	NNS
cord-337365-hugenn14	62	15	which	which	WDT
cord-337365-hugenn14	62	16	indicates	indicate	VBZ
cord-337365-hugenn14	62	17	that	that	IN
cord-337365-hugenn14	62	18	P2Y12	P2Y12	NNP
cord-337365-hugenn14	62	19	is	be	VBZ
cord-337365-hugenn14	62	20	essential	essential	JJ
cord-337365-hugenn14	62	21	for	for	IN
cord-337365-hugenn14	62	22	microglia	microglia	NNS
cord-337365-hugenn14	62	23	to	to	TO
cord-337365-hugenn14	62	24	exert	exert	VB
cord-337365-hugenn14	62	25	phagocytic	phagocytic	JJ
cord-337365-hugenn14	62	26	activity	activity	NN
cord-337365-hugenn14	62	27	[	[	-LRB-
cord-337365-hugenn14	62	28	9	9	CD
cord-337365-hugenn14	62	29	]	]	-RRB-
cord-337365-hugenn14	62	30	.	.	.
cord-337365-hugenn14	63	1	Microglia	Microglia	NNP
cord-337365-hugenn14	63	2	are	be	VBP
cord-337365-hugenn14	63	3	key	key	JJ
cord-337365-hugenn14	63	4	contributors	contributor	NNS
cord-337365-hugenn14	63	5	to	to	IN
cord-337365-hugenn14	63	6	the	the	DT
cord-337365-hugenn14	63	7	recruitment	recruitment	NN
cord-337365-hugenn14	63	8	of	of	IN
cord-337365-hugenn14	63	9	monocytes	monocyte	NNS
cord-337365-hugenn14	63	10	into	into	IN
cord-337365-hugenn14	63	11	the	the	DT
cord-337365-hugenn14	63	12	brain	brain	NN
cord-337365-hugenn14	63	13	during	during	IN
cord-337365-hugenn14	63	14	viral	viral	JJ
cord-337365-hugenn14	63	15	infection	infection	NN
cord-337365-hugenn14	63	16	.	.	.
cord-337365-hugenn14	64	1	In	in	IN
cord-337365-hugenn14	64	2	microglia	microglia	NN
cord-337365-hugenn14	64	3	-	-	HYPH
cord-337365-hugenn14	64	4	depleted	deplete	VBN
cord-337365-hugenn14	64	5	mice	mouse	NNS
cord-337365-hugenn14	64	6	,	,	,
cord-337365-hugenn14	64	7	the	the	DT
cord-337365-hugenn14	64	8	phenomenon	phenomenon	NN
cord-337365-hugenn14	64	9	of	of	IN
cord-337365-hugenn14	64	10	monocytes	monocyte	NNS
cord-337365-hugenn14	64	11	entering	enter	VBG
cord-337365-hugenn14	64	12	the	the	DT
cord-337365-hugenn14	64	13	brain	brain	NN
cord-337365-hugenn14	64	14	is	be	VBZ
cord-337365-hugenn14	64	15	almost	almost	RB
cord-337365-hugenn14	64	16	completely	completely	RB
cord-337365-hugenn14	64	17	gone	go	VBN
cord-337365-hugenn14	64	18	.	.	.
cord-337365-hugenn14	65	1	CD45	CD45	NNP
cord-337365-hugenn14	65	2	+	+	CC
cord-337365-hugenn14	65	3	blood	blood	NN
cord-337365-hugenn14	65	4	-	-	HYPH
cord-337365-hugenn14	65	5	borne	bear	VBN
cord-337365-hugenn14	65	6	leukocytes	leukocyte	NNS
cord-337365-hugenn14	65	7	were	be	VBD
cord-337365-hugenn14	65	8	seen	see	VBN
cord-337365-hugenn14	65	9	in	in	IN
cord-337365-hugenn14	65	10	the	the	DT
cord-337365-hugenn14	65	11	brain	brain	NN
cord-337365-hugenn14	65	12	of	of	IN
cord-337365-hugenn14	65	13	P2Y12	P2Y12	NNP
cord-337365-hugenn14	65	14	−/−	−/−	NNP
cord-337365-hugenn14	65	15	mice	mouse	NNS
cord-337365-hugenn14	65	16	after	after	IN
cord-337365-hugenn14	65	17	infection	infection	NN
cord-337365-hugenn14	65	18	,	,	,
cord-337365-hugenn14	65	19	and	and	CC
cord-337365-hugenn14	65	20	mononuclear	mononuclear	JJ
cord-337365-hugenn14	65	21	cell	cell	NN
cord-337365-hugenn14	65	22	infiltration	infiltration	NN
cord-337365-hugenn14	65	23	was	be	VBD
cord-337365-hugenn14	65	24	not	not	RB
cord-337365-hugenn14	65	25	impaired	impair	VBN
cord-337365-hugenn14	65	26	,	,	,
cord-337365-hugenn14	65	27	which	which	WDT
cord-337365-hugenn14	65	28	indicates	indicate	VBZ
cord-337365-hugenn14	65	29	that	that	IN
cord-337365-hugenn14	65	30	microglia	microglia	NNP
cord-337365-hugenn14	65	31	recruit	recruit	VBP
cord-337365-hugenn14	65	32	monocytes	monocyte	VBZ
cord-337365-hugenn14	65	33	through	through	IN
cord-337365-hugenn14	65	34	a	a	DT
cord-337365-hugenn14	65	35	P2Y12	P2Y12	NNP
cord-337365-hugenn14	65	36	independent	independent	JJ
cord-337365-hugenn14	65	37	mechanism	mechanism	NN
cord-337365-hugenn14	65	38	[	[	-LRB-
cord-337365-hugenn14	65	39	9	9	CD
cord-337365-hugenn14	65	40	]	]	-RRB-
cord-337365-hugenn14	65	41	.	.	.
cord-337365-hugenn14	66	1	Analysis	analysis	NN
cord-337365-hugenn14	66	2	of	of	IN
cord-337365-hugenn14	66	3	temporal	temporal	JJ
cord-337365-hugenn14	66	4	lobe	lobe	NN
cord-337365-hugenn14	66	5	specimens	specimen	NNS
cord-337365-hugenn14	66	6	in	in	IN
cord-337365-hugenn14	66	7	patients	patient	NNS
cord-337365-hugenn14	66	8	with	with	IN
cord-337365-hugenn14	66	9	herpes	herpes	NN
cord-337365-hugenn14	66	10	simplex	simplex	NN
cord-337365-hugenn14	66	11	type	type	NN
cord-337365-hugenn14	66	12	1	1	CD
cord-337365-hugenn14	67	1	(	(	-LRB-
cord-337365-hugenn14	67	2	HSV-1	hsv-1	NN
cord-337365-hugenn14	67	3	)	)	-RRB-
cord-337365-hugenn14	67	4	encephalitis	encephalitis	NN
cord-337365-hugenn14	67	5	shows	show	VBZ
cord-337365-hugenn14	67	6	that	that	IN
cord-337365-hugenn14	67	7	P2Y12-positive	p2y12-positive	JJ
cord-337365-hugenn14	67	8	microglia	microglia	NN
cord-337365-hugenn14	67	9	processes	process	NNS
cord-337365-hugenn14	67	10	extend	extend	VBP
cord-337365-hugenn14	67	11	to	to	IN
cord-337365-hugenn14	67	12	HSV-1	hsv-1	VB
cord-337365-hugenn14	67	13	positive	positive	JJ
cord-337365-hugenn14	67	14	cells	cell	NNS
cord-337365-hugenn14	67	15	,	,	,
cord-337365-hugenn14	67	16	and	and	CC
cord-337365-hugenn14	67	17	there	there	EX
cord-337365-hugenn14	67	18	are	be	VBP
cord-337365-hugenn14	67	19	about	about	RB
cord-337365-hugenn14	67	20	1	1	CD
cord-337365-hugenn14	67	21	-	-	SYM
cord-337365-hugenn14	67	22	3	3	CD
cord-337365-hugenn14	67	23	activated	activate	VBN
cord-337365-hugenn14	67	24	microglia	microglia	NN
cord-337365-hugenn14	67	25	around	around	IN
cord-337365-hugenn14	67	26	each	each	DT
cord-337365-hugenn14	67	27	infected	infect	VBN
cord-337365-hugenn14	67	28	neuron	neuron	NN
cord-337365-hugenn14	67	29	.	.	.
cord-337365-hugenn14	68	1	Microglia	Microglia	NNP
cord-337365-hugenn14	68	2	appear	appear	VBP
cord-337365-hugenn14	68	3	around	around	IN
cord-337365-hugenn14	68	4	the	the	DT
cord-337365-hugenn14	68	5	cell	cell	NN
cord-337365-hugenn14	68	6	bodies	body	NNS
cord-337365-hugenn14	68	7	and	and	CC
cord-337365-hugenn14	68	8	dendrites	dendrite	NNS
cord-337365-hugenn14	68	9	of	of	IN
cord-337365-hugenn14	68	10	neurons	neuron	NNS
cord-337365-hugenn14	68	11	before	before	IN
cord-337365-hugenn14	68	12	the	the	DT
cord-337365-hugenn14	68	13	mature	mature	JJ
cord-337365-hugenn14	68	14	virus	virus	NN
cord-337365-hugenn14	68	15	particles	particle	NNS
cord-337365-hugenn14	68	16	appear	appear	VBP
cord-337365-hugenn14	68	17	in	in	IN
cord-337365-hugenn14	68	18	infected	infected	JJ
cord-337365-hugenn14	68	19	neuronal	neuronal	JJ
cord-337365-hugenn14	68	20	cells	cell	NNS
cord-337365-hugenn14	68	21	.	.	.
cord-337365-hugenn14	69	1	At	at	IN
cord-337365-hugenn14	69	2	this	this	DT
cord-337365-hugenn14	69	3	stage	stage	NN
cord-337365-hugenn14	69	4	,	,	,
cord-337365-hugenn14	69	5	the	the	DT
cord-337365-hugenn14	69	6	neuronal	neuronal	JJ
cord-337365-hugenn14	69	7	membrane	membrane	NN
cord-337365-hugenn14	69	8	is	be	VBZ
cord-337365-hugenn14	69	9	intact	intact	JJ
cord-337365-hugenn14	69	10	and	and	CC
cord-337365-hugenn14	69	11	there	there	EX
cord-337365-hugenn14	69	12	is	be	VBZ
cord-337365-hugenn14	69	13	a	a	DT
cord-337365-hugenn14	69	14	normal	normal	JJ
cord-337365-hugenn14	69	15	chromatin	chromatin	NN
cord-337365-hugenn14	69	16	structure	structure	NN
cord-337365-hugenn14	69	17	in	in	IN
cord-337365-hugenn14	69	18	the	the	DT
cord-337365-hugenn14	69	19	nucleus	nucleus	NN
cord-337365-hugenn14	69	20	.	.	.
cord-337365-hugenn14	70	1	Cell	cell	NN
cord-337365-hugenn14	70	2	trajectory	trajectory	NN
cord-337365-hugenn14	70	3	analysis	analysis	NN
cord-337365-hugenn14	70	4	has	have	VBZ
cord-337365-hugenn14	70	5	shown	show	VBN
cord-337365-hugenn14	70	6	that	that	IN
cord-337365-hugenn14	70	7	the	the	DT
cord-337365-hugenn14	70	8	speed	speed	NN
cord-337365-hugenn14	70	9	of	of	IN
cord-337365-hugenn14	70	10	microglia	microglia	JJ
cord-337365-hugenn14	70	11	movement	movement	NN
cord-337365-hugenn14	70	12	in	in	IN
cord-337365-hugenn14	70	13	mice	mouse	NNS
cord-337365-hugenn14	70	14	with	with	IN
cord-337365-hugenn14	70	15	viral	viral	JJ
cord-337365-hugenn14	70	16	encephalitis	encephalitis	NN
cord-337365-hugenn14	70	17	is	be	VBZ
cord-337365-hugenn14	70	18	reduced	reduce	VBN
cord-337365-hugenn14	70	19	,	,	,
cord-337365-hugenn14	70	20	which	which	WDT
cord-337365-hugenn14	70	21	is	be	VBZ
cord-337365-hugenn14	70	22	related	relate	VBN
cord-337365-hugenn14	70	23	to	to	IN
cord-337365-hugenn14	70	24	their	-PRON-	PRP$
cord-337365-hugenn14	70	25	tendency	tendency	NN
cord-337365-hugenn14	70	26	to	to	TO
cord-337365-hugenn14	70	27	stay	stay	VB
cord-337365-hugenn14	70	28	around	around	IN
cord-337365-hugenn14	70	29	the	the	DT
cord-337365-hugenn14	70	30	infected	infected	JJ
cord-337365-hugenn14	70	31	cells	cell	NNS
cord-337365-hugenn14	70	32	[	[	-LRB-
cord-337365-hugenn14	70	33	9	9	CD
cord-337365-hugenn14	70	34	]	]	-RRB-
cord-337365-hugenn14	70	35	.	.	.
cord-337365-hugenn14	71	1	Typical	typical	JJ
cord-337365-hugenn14	71	2	neurological	neurological	JJ
cord-337365-hugenn14	71	3	symptoms	symptom	NNS
cord-337365-hugenn14	71	4	appear	appear	VBP
cord-337365-hugenn14	71	5	in	in	IN
cord-337365-hugenn14	71	6	mice	mouse	NNS
cord-337365-hugenn14	71	7	infected	infect	VBN
cord-337365-hugenn14	71	8	with	with	IN
cord-337365-hugenn14	71	9	virus	virus	NN
cord-337365-hugenn14	71	10	when	when	WRB
cord-337365-hugenn14	71	11	microglia	microglia	NNS
cord-337365-hugenn14	71	12	are	be	VBP
cord-337365-hugenn14	71	13	completely	completely	RB
cord-337365-hugenn14	71	14	absent	absent	JJ
cord-337365-hugenn14	71	15	,	,	,
cord-337365-hugenn14	71	16	but	but	CC
cord-337365-hugenn14	71	17	not	not	RB
cord-337365-hugenn14	71	18	P2Y12	P2Y12	NNP
cord-337365-hugenn14	71	19	deficiency	deficiency	NN
cord-337365-hugenn14	71	20	[	[	-LRB-
cord-337365-hugenn14	71	21	9	9	CD
cord-337365-hugenn14	71	22	]	]	-RRB-
cord-337365-hugenn14	71	23	.	.	.
cord-337365-hugenn14	72	1	Consistent	consistent	JJ
cord-337365-hugenn14	72	2	with	with	IN
cord-337365-hugenn14	72	3	this	this	DT
cord-337365-hugenn14	72	4	,	,	,
cord-337365-hugenn14	72	5	mice	mouse	NNS
cord-337365-hugenn14	72	6	with	with	IN
cord-337365-hugenn14	72	7	microglia	microglia	JJ
cord-337365-hugenn14	72	8	depletion	depletion	NN
cord-337365-hugenn14	72	9	have	have	VBP
cord-337365-hugenn14	72	10	higher	high	JJR
cord-337365-hugenn14	72	11	viral	viral	JJ
cord-337365-hugenn14	72	12	loads	load	NNS
cord-337365-hugenn14	72	13	and	and	CC
cord-337365-hugenn14	72	14	succumb	succumb	VBP
cord-337365-hugenn14	72	15	to	to	IN
cord-337365-hugenn14	72	16	infection	infection	NN
cord-337365-hugenn14	72	17	.	.	.
cord-337365-hugenn14	73	1	The	the	DT
cord-337365-hugenn14	73	2	rapidly	rapidly	RB
cord-337365-hugenn14	73	3	deteriorating	deteriorate	VBG
cord-337365-hugenn14	73	4	neurological	neurological	JJ
cord-337365-hugenn14	73	5	symptoms	symptom	NNS
cord-337365-hugenn14	73	6	in	in	IN
cord-337365-hugenn14	73	7	microglia	microglia	NN
cord-337365-hugenn14	73	8	-	-	HYPH
cord-337365-hugenn14	73	9	depleted	deplete	VBN
cord-337365-hugenn14	73	10	mice	mouse	NNS
cord-337365-hugenn14	73	11	may	may	MD
cord-337365-hugenn14	73	12	be	be	VB
cord-337365-hugenn14	73	13	associated	associate	VBN
cord-337365-hugenn14	73	14	with	with	IN
cord-337365-hugenn14	73	15	significantly	significantly	RB
cord-337365-hugenn14	73	16	increased	increase	VBN
cord-337365-hugenn14	73	17	neuronal	neuronal	JJ
cord-337365-hugenn14	73	18	infection	infection	NN
cord-337365-hugenn14	73	19	and	and	CC
cord-337365-hugenn14	73	20	potential	potential	JJ
cord-337365-hugenn14	73	21	microglial	microglial	JJ
cord-337365-hugenn14	73	22	protective	protective	JJ
cord-337365-hugenn14	73	23	mediators	mediator	NNS
cord-337365-hugenn14	73	24	such	such	JJ
cord-337365-hugenn14	73	25	as	as	IN
cord-337365-hugenn14	73	26	interleukin-10	interleukin-10	NNP
cord-337365-hugenn14	73	27	deficiency	deficiency	NN
cord-337365-hugenn14	73	28	[	[	-LRB-
cord-337365-hugenn14	73	29	13	13	CD
cord-337365-hugenn14	73	30	]	]	-RRB-
cord-337365-hugenn14	73	31	.	.	.
cord-337365-hugenn14	74	1	Microglia	Microglia	NNP
cord-337365-hugenn14	74	2	play	play	VBP
cord-337365-hugenn14	74	3	a	a	DT
cord-337365-hugenn14	74	4	direct	direct	JJ
cord-337365-hugenn14	74	5	antiviral	antiviral	JJ
cord-337365-hugenn14	74	6	effect	effect	NN
cord-337365-hugenn14	74	7	by	by	IN
cord-337365-hugenn14	74	8	producing	produce	VBG
cord-337365-hugenn14	74	9	IFN-1	IFN-1	NNP
cord-337365-hugenn14	75	1	after	after	IN
cord-337365-hugenn14	75	2	recognition	recognition	NN
cord-337365-hugenn14	75	3	of	of	IN
cord-337365-hugenn14	75	4	virus	virus	NN
cord-337365-hugenn14	75	5	by	by	IN
cord-337365-hugenn14	75	6	pattern	pattern	NN
cord-337365-hugenn14	75	7	recognition	recognition	NN
cord-337365-hugenn14	75	8	receptors	receptor	NNS
cord-337365-hugenn14	75	9	(	(	-LRB-
cord-337365-hugenn14	75	10	PRRs	PRRs	NNP
cord-337365-hugenn14	75	11	)	)	-RRB-
cord-337365-hugenn14	75	12	Mouse	Mouse	NNP
cord-337365-hugenn14	75	13	hepatitis	hepatitis	NN
cord-337365-hugenn14	75	14	virus	virus	NN
cord-337365-hugenn14	75	15	(	(	-LRB-
cord-337365-hugenn14	75	16	MHV	MHV	NNP
cord-337365-hugenn14	75	17	)	)	-RRB-
cord-337365-hugenn14	75	18	is	be	VBZ
cord-337365-hugenn14	75	19	a	a	DT
cord-337365-hugenn14	75	20	neurotropic	neurotropic	JJ
cord-337365-hugenn14	75	21	coronavirus	coronavirus	NN
cord-337365-hugenn14	75	22	.	.	.
cord-337365-hugenn14	76	1	On	on	IN
cord-337365-hugenn14	76	2	the	the	DT
cord-337365-hugenn14	76	3	fourth	fourth	JJ
cord-337365-hugenn14	76	4	day	day	NN
cord-337365-hugenn14	76	5	of	of	IN
cord-337365-hugenn14	76	6	viral	viral	JJ
cord-337365-hugenn14	76	7	infection	infection	NN
cord-337365-hugenn14	76	8	,	,	,
cord-337365-hugenn14	76	9	microarray	microarray	NN
cord-337365-hugenn14	76	10	analysis	analysis	NN
cord-337365-hugenn14	76	11	of	of	IN
cord-337365-hugenn14	76	12	infected	infected	JJ
cord-337365-hugenn14	76	13	mouse	mouse	NN
cord-337365-hugenn14	76	14	microglia	microglia	NNS
cord-337365-hugenn14	76	15	showed	show	VBD
cord-337365-hugenn14	76	16	that	that	IN
cord-337365-hugenn14	76	17	the	the	DT
cord-337365-hugenn14	76	18	IFN-1	IFN-1	NNP
cord-337365-hugenn14	76	19	pathway	pathway	NN
cord-337365-hugenn14	76	20	was	be	VBD
cord-337365-hugenn14	76	21	the	the	DT
cord-337365-hugenn14	76	22	most	most	RBS
cord-337365-hugenn14	76	23	upregulated	upregulated	JJ
cord-337365-hugenn14	76	24	[	[	-LRB-
cord-337365-hugenn14	76	25	14	14	CD
cord-337365-hugenn14	76	26	]	]	-RRB-
cord-337365-hugenn14	76	27	.	.	.
cord-337365-hugenn14	77	1	IFN-1	IFN-1	NNP
cord-337365-hugenn14	77	2	protects	protect	VBZ
cord-337365-hugenn14	77	3	the	the	DT
cord-337365-hugenn14	77	4	host	host	NN
cord-337365-hugenn14	77	5	because	because	IN
cord-337365-hugenn14	77	6	treatment	treatment	NN
cord-337365-hugenn14	77	7	with	with	IN
cord-337365-hugenn14	77	8	exogenous	exogenous	JJ
cord-337365-hugenn14	77	9	IFN	IFN	NNP
cord-337365-hugenn14	77	10	-	-	HYPH
cord-337365-hugenn14	77	11	α	α	NNP
cord-337365-hugenn14	77	12	or	or	CC
cord-337365-hugenn14	77	13	IFN	IFN	NNP
cord-337365-hugenn14	77	14	-	-	HYPH
cord-337365-hugenn14	77	15	β	β	NNP
cord-337365-hugenn14	77	16	limits	limit	VBZ
cord-337365-hugenn14	77	17	viral	viral	JJ
cord-337365-hugenn14	77	18	replication	replication	NN
cord-337365-hugenn14	77	19	,	,	,
cord-337365-hugenn14	77	20	whereas	whereas	IN
cord-337365-hugenn14	77	21	the	the	DT
cord-337365-hugenn14	77	22	infection	infection	NN
cord-337365-hugenn14	77	23	of	of	IN
cord-337365-hugenn14	77	24	mice	mouse	NNS
cord-337365-hugenn14	77	25	with	with	IN
cord-337365-hugenn14	77	26	IFN-1	IFN-1	NNP
cord-337365-hugenn14	77	27	signaling	signal	VBG
cord-337365-hugenn14	77	28	deficiency	deficiency	NN
cord-337365-hugenn14	77	29	can	can	MD
cord-337365-hugenn14	77	30	convert	convert	VB
cord-337365-hugenn14	77	31	nonfatal	nonfatal	JJ
cord-337365-hugenn14	77	32	coronavirus	coronavirus	NN
cord-337365-hugenn14	77	33	to	to	IN
cord-337365-hugenn14	77	34	a	a	DT
cord-337365-hugenn14	77	35	lethal	lethal	JJ
cord-337365-hugenn14	77	36	type	type	NN
cord-337365-hugenn14	77	37	[	[	-LRB-
cord-337365-hugenn14	77	38	15	15	CD
cord-337365-hugenn14	77	39	]	]	-RRB-
cord-337365-hugenn14	77	40	.	.	.
cord-337365-hugenn14	78	1	In	in	IN
cord-337365-hugenn14	78	2	the	the	DT
cord-337365-hugenn14	78	3	mouse	mouse	NN
cord-337365-hugenn14	78	4	model	model	NN
cord-337365-hugenn14	78	5	of	of	IN
cord-337365-hugenn14	78	6	vesicular	vesicular	JJ
cord-337365-hugenn14	78	7	stomatitis	stomatitis	NN
cord-337365-hugenn14	78	8	virus	virus	NN
cord-337365-hugenn14	78	9	(	(	-LRB-
cord-337365-hugenn14	78	10	VSV	VSV	NNP
cord-337365-hugenn14	78	11	)	)	-RRB-
cord-337365-hugenn14	78	12	encephalitis	encephalitis	RB
cord-337365-hugenn14	78	13	,	,	,
cord-337365-hugenn14	78	14	it	-PRON-	PRP
cord-337365-hugenn14	78	15	was	be	VBD
cord-337365-hugenn14	78	16	found	find	VBN
cord-337365-hugenn14	78	17	that	that	IN
cord-337365-hugenn14	78	18	infected	infected	JJ
cord-337365-hugenn14	78	19	microglia	microglia	NN
cord-337365-hugenn14	78	20	produced	produce	VBD
cord-337365-hugenn14	78	21	IFN-1	IFN-1	NNP
cord-337365-hugenn14	78	22	,	,	,
cord-337365-hugenn14	78	23	and	and	CC
cord-337365-hugenn14	78	24	both	both	DT
cord-337365-hugenn14	78	25	infected	infected	JJ
cord-337365-hugenn14	78	26	and	and	CC
cord-337365-hugenn14	78	27	uninfected	uninfected	JJ
cord-337365-hugenn14	78	28	microglia	microglia	NNS
cord-337365-hugenn14	78	29	upregulated	upregulate	VBD
cord-337365-hugenn14	78	30	the	the	DT
cord-337365-hugenn14	78	31	expression	expression	NN
cord-337365-hugenn14	78	32	of	of	IN
cord-337365-hugenn14	78	33	IFN	IFN	NNP
cord-337365-hugenn14	78	34	regulatory	regulatory	JJ
cord-337365-hugenn14	78	35	factors	factor	NNS
cord-337365-hugenn14	78	36	7	7	CD
cord-337365-hugenn14	78	37	(	(	-LRB-
cord-337365-hugenn14	78	38	IRF7	IRF7	NNP
cord-337365-hugenn14	78	39	)	)	-RRB-
cord-337365-hugenn14	78	40	and	and	CC
cord-337365-hugenn14	78	41	activated	activate	VBN
cord-337365-hugenn14	78	42	innate	innate	JJ
cord-337365-hugenn14	78	43	immunity	immunity	NN
cord-337365-hugenn14	78	44	which	which	WDT
cord-337365-hugenn14	78	45	limits	limit	VBZ
cord-337365-hugenn14	78	46	the	the	DT
cord-337365-hugenn14	78	47	transsynaptic	transsynaptic	JJ
cord-337365-hugenn14	78	48	spread	spread	NN
cord-337365-hugenn14	78	49	of	of	IN
cord-337365-hugenn14	78	50	VSV	VSV	NNP
cord-337365-hugenn14	78	51	[	[	-LRB-
cord-337365-hugenn14	78	52	16	16	CD
cord-337365-hugenn14	78	53	]	]	-RRB-
cord-337365-hugenn14	78	54	.	.	.
cord-337365-hugenn14	79	1	Viral	viral	JJ
cord-337365-hugenn14	79	2	infection	infection	NN
cord-337365-hugenn14	79	3	can	can	MD
cord-337365-hugenn14	79	4	induce	induce	VB
cord-337365-hugenn14	79	5	the	the	DT
cord-337365-hugenn14	79	6	expression	expression	NN
cord-337365-hugenn14	79	7	of	of	IN
cord-337365-hugenn14	79	8	IFN	IFN	NNP
cord-337365-hugenn14	79	9	-	-	HYPH
cord-337365-hugenn14	79	10	stimulated	stimulate	VBN
cord-337365-hugenn14	79	11	genes	gene	NNS
cord-337365-hugenn14	79	12	(	(	-LRB-
cord-337365-hugenn14	79	13	ISGs	ISGs	NNP
cord-337365-hugenn14	79	14	)	)	-RRB-
cord-337365-hugenn14	79	15	,	,	,
cord-337365-hugenn14	79	16	thereby	thereby	RB
cord-337365-hugenn14	79	17	interfering	interfere	VBG
cord-337365-hugenn14	79	18	with	with	IN
cord-337365-hugenn14	79	19	viral	viral	JJ
cord-337365-hugenn14	79	20	replication	replication	NN
cord-337365-hugenn14	79	21	and	and	CC
cord-337365-hugenn14	79	22	promoting	promote	VBG
cord-337365-hugenn14	79	23	viral	viral	JJ
cord-337365-hugenn14	79	24	clearance	clearance	NN
cord-337365-hugenn14	79	25	[	[	-LRB-
cord-337365-hugenn14	79	26	16	16	CD
cord-337365-hugenn14	79	27	]	]	-RRB-
cord-337365-hugenn14	79	28	(	(	-LRB-
cord-337365-hugenn14	79	29	see	see	VB
cord-337365-hugenn14	79	30	Fig	Fig	NNP
cord-337365-hugenn14	79	31	.	.	NNP
cord-337365-hugenn14	79	32	1	1	CD
cord-337365-hugenn14	79	33	)	)	-RRB-
cord-337365-hugenn14	79	34	.	.	.
cord-337365-hugenn14	80	1	Microglia	Microglia	NNP
cord-337365-hugenn14	80	2	express	express	VBP
cord-337365-hugenn14	80	3	a	a	DT
cord-337365-hugenn14	80	4	wide	wide	JJ
cord-337365-hugenn14	80	5	range	range	NN
cord-337365-hugenn14	80	6	of	of	IN
cord-337365-hugenn14	80	7	PRRs	prr	NNS
cord-337365-hugenn14	80	8	,	,	,
cord-337365-hugenn14	80	9	which	which	WDT
cord-337365-hugenn14	80	10	are	be	VBP
cord-337365-hugenn14	80	11	important	important	JJ
cord-337365-hugenn14	80	12	for	for	IN
cord-337365-hugenn14	80	13	the	the	DT
cord-337365-hugenn14	80	14	defense	defense	NN
cord-337365-hugenn14	80	15	of	of	IN
cord-337365-hugenn14	80	16	HSV-1	HSV-1	NNP
cord-337365-hugenn14	80	17	.	.	.
cord-337365-hugenn14	81	1	Virus	virus	NN
cord-337365-hugenn14	81	2	induces	induce	VBZ
cord-337365-hugenn14	81	3	expression	expression	NN
cord-337365-hugenn14	81	4	of	of	IN
cord-337365-hugenn14	81	5	IFN-1	IFN-1	NNP
cord-337365-hugenn14	81	6	by	by	IN
cord-337365-hugenn14	81	7	the	the	DT
cord-337365-hugenn14	81	8	recognition	recognition	NN
cord-337365-hugenn14	81	9	of	of	IN
cord-337365-hugenn14	81	10	nucleotides	nucleotide	NNS
cord-337365-hugenn14	81	11	and	and	CC
cord-337365-hugenn14	81	12	(	(	-LRB-
cord-337365-hugenn14	81	13	RNA-/DNA	rna-/dna	NN
cord-337365-hugenn14	81	14	-	-	HYPH
cord-337365-hugenn14	81	15	sensing	sense	VBG
cord-337365-hugenn14	81	16	)	)	-RRB-
cord-337365-hugenn14	81	17	PRRs	PRRs	NNP
cord-337365-hugenn14	81	18	[	[	-LRB-
cord-337365-hugenn14	81	19	7	7	CD
cord-337365-hugenn14	81	20	,	,	,
cord-337365-hugenn14	81	21	8	8	CD
cord-337365-hugenn14	81	22	]	]	-RRB-
cord-337365-hugenn14	81	23	(	(	-LRB-
cord-337365-hugenn14	81	24	see	see	VB
cord-337365-hugenn14	81	25	Table	table	NN
cord-337365-hugenn14	81	26	1	1	CD
cord-337365-hugenn14	81	27	for	for	IN
cord-337365-hugenn14	81	28	a	a	DT
cord-337365-hugenn14	81	29	summary	summary	NN
cord-337365-hugenn14	81	30	)	)	-RRB-
cord-337365-hugenn14	81	31	.	.	.
cord-337365-hugenn14	82	1	The	the	DT
cord-337365-hugenn14	82	2	combination	combination	NN
cord-337365-hugenn14	82	3	of	of	IN
cord-337365-hugenn14	82	4	IFN-1	IFN-1	NNP
cord-337365-hugenn14	82	5	and	and	CC
cord-337365-hugenn14	82	6	the	the	DT
cord-337365-hugenn14	82	7	heterodimeric	heterodimeric	JJ
cord-337365-hugenn14	82	8	receptor	receptor	NN
cord-337365-hugenn14	82	9	IFNAR	IFNAR	NNP
cord-337365-hugenn14	82	10	produces	produce	VBZ
cord-337365-hugenn14	82	11	a	a	DT
cord-337365-hugenn14	82	12	cellular	cellular	JJ
cord-337365-hugenn14	82	13	response	response	NN
cord-337365-hugenn14	82	14	that	that	WDT
cord-337365-hugenn14	82	15	initiates	initiate	VBZ
cord-337365-hugenn14	82	16	a	a	DT
cord-337365-hugenn14	82	17	signaling	signal	VBG
cord-337365-hugenn14	82	18	cascade	cascade	NN
cord-337365-hugenn14	82	19	that	that	WDT
cord-337365-hugenn14	82	20	promotes	promote	VBZ
cord-337365-hugenn14	82	21	heterodimers	heterodimer	NNS
cord-337365-hugenn14	82	22	STAT	stat	NN
cord-337365-hugenn14	82	23	1/2	1/2	CD
cord-337365-hugenn14	82	24	nuclear	nuclear	JJ
cord-337365-hugenn14	82	25	translocation	translocation	NN
cord-337365-hugenn14	82	26	and	and	CC
cord-337365-hugenn14	82	27	transcriptional	transcriptional	JJ
cord-337365-hugenn14	82	28	activation	activation	NN
cord-337365-hugenn14	82	29	of	of	IN
cord-337365-hugenn14	82	30	ISGs	ISGs	NNPS
cord-337365-hugenn14	82	31	[	[	-LRB-
cord-337365-hugenn14	82	32	17	17	CD
cord-337365-hugenn14	82	33	]	]	-RRB-
cord-337365-hugenn14	82	34	.	.	.
cord-337365-hugenn14	83	1	The	the	DT
cord-337365-hugenn14	83	2	rapid	rapid	JJ
cord-337365-hugenn14	83	3	expression	expression	NN
cord-337365-hugenn14	83	4	of	of	IN
cord-337365-hugenn14	83	5	hundreds	hundred	NNS
cord-337365-hugenn14	83	6	of	of	IN
cord-337365-hugenn14	83	7	ISGs	ISGs	NNPS
cord-337365-hugenn14	83	8	is	be	VBZ
cord-337365-hugenn14	83	9	critical	critical	JJ
cord-337365-hugenn14	83	10	for	for	IN
cord-337365-hugenn14	83	11	controlling	control	VBG
cord-337365-hugenn14	83	12	viral	viral	JJ
cord-337365-hugenn14	83	13	infections	infection	NNS
cord-337365-hugenn14	83	14	because	because	IN
cord-337365-hugenn14	83	15	these	these	DT
cord-337365-hugenn14	83	16	proteins	protein	NNS
cord-337365-hugenn14	83	17	block	block	VBP
cord-337365-hugenn14	83	18	the	the	DT
cord-337365-hugenn14	83	19	entry	entry	NN
cord-337365-hugenn14	83	20	,	,	,
cord-337365-hugenn14	83	21	translation	translation	NN
cord-337365-hugenn14	83	22	,	,	,
cord-337365-hugenn14	83	23	transcription	transcription	NN
cord-337365-hugenn14	83	24	,	,	,
cord-337365-hugenn14	83	25	assembly	assembly	NN
cord-337365-hugenn14	83	26	,	,	,
cord-337365-hugenn14	83	27	and	and	CC
cord-337365-hugenn14	83	28	efflux	efflux	NN
cord-337365-hugenn14	83	29	of	of	IN
cord-337365-hugenn14	83	30	the	the	DT
cord-337365-hugenn14	83	31	virus	virus	NN
cord-337365-hugenn14	83	32	[	[	-LRB-
cord-337365-hugenn14	83	33	18	18	CD
cord-337365-hugenn14	83	34	]	]	-RRB-
cord-337365-hugenn14	83	35	.	.	.
cord-337365-hugenn14	84	1	Cytosolic	Cytosolic	NNP
cord-337365-hugenn14	84	2	dsDNAs	dsdna	NNS
cord-337365-hugenn14	84	3	can	can	MD
cord-337365-hugenn14	84	4	induce	induce	VB
cord-337365-hugenn14	84	5	a	a	DT
cord-337365-hugenn14	84	6	strong	strong	JJ
cord-337365-hugenn14	84	7	innate	innate	JJ
cord-337365-hugenn14	84	8	immune	immune	JJ
cord-337365-hugenn14	84	9	response	response	NN
cord-337365-hugenn14	84	10	.	.	.
cord-337365-hugenn14	85	1	GMP	GMP	NNP
cord-337365-hugenn14	85	2	-	-	HYPH
cord-337365-hugenn14	85	3	AMP	AMP	NNP
cord-337365-hugenn14	85	4	synthase	synthase	NN
cord-337365-hugenn14	85	5	(	(	-LRB-
cord-337365-hugenn14	85	6	cGAS	cGAS	NNP
cord-337365-hugenn14	85	7	)	)	-RRB-
cord-337365-hugenn14	85	8	is	be	VBZ
cord-337365-hugenn14	85	9	a	a	DT
cord-337365-hugenn14	85	10	cytosolic	cytosolic	JJ
cord-337365-hugenn14	85	11	DNA	dna	NN
cord-337365-hugenn14	85	12	receptor	receptor	NN
cord-337365-hugenn14	85	13	[	[	-LRB-
cord-337365-hugenn14	85	14	19	19	CD
cord-337365-hugenn14	85	15	]	]	-RRB-
cord-337365-hugenn14	85	16	.	.	.
cord-337365-hugenn14	86	1	The	the	DT
cord-337365-hugenn14	86	2	binding	binding	NN
cord-337365-hugenn14	86	3	of	of	IN
cord-337365-hugenn14	86	4	cGAS	cgas	NN
cord-337365-hugenn14	86	5	to	to	IN
cord-337365-hugenn14	86	6	cytosolic	cytosolic	JJ
cord-337365-hugenn14	86	7	DNA	DNA	NNP
cord-337365-hugenn14	86	8	produces	produce	VBZ
cord-337365-hugenn14	86	9	a	a	DT
cord-337365-hugenn14	86	10	second	second	JJ
cord-337365-hugenn14	86	11	messenger	messenger	NN
cord-337365-hugenn14	86	12	,	,	,
cord-337365-hugenn14	86	13	cyclic	cyclic	JJ
cord-337365-hugenn14	86	14	-	-	HYPH
cord-337365-hugenn14	86	15	GMP	GMP	NNP
cord-337365-hugenn14	86	16	-	-	HYPH
cord-337365-hugenn14	86	17	AMP	AMP	NNP
cord-337365-hugenn14	86	18	(	(	-LRB-
cord-337365-hugenn14	86	19	cGAMP	cGAMP	NNP
cord-337365-hugenn14	86	20	)	)	-RRB-
cord-337365-hugenn14	86	21	,	,	,
cord-337365-hugenn14	86	22	which	which	WDT
cord-337365-hugenn14	86	23	activates	activate	VBZ
cord-337365-hugenn14	86	24	downstream	downstream	JJ
cord-337365-hugenn14	86	25	STING	sting	NN
cord-337365-hugenn14	86	26	and	and	CC
cord-337365-hugenn14	86	27	ultimately	ultimately	RB
cord-337365-hugenn14	86	28	activates	activate	VBZ
cord-337365-hugenn14	86	29	transcription	transcription	NN
cord-337365-hugenn14	86	30	factor	factor	NN
cord-337365-hugenn14	86	31	IRF3	IRF3	NNP
cord-337365-hugenn14	86	32	,	,	,
cord-337365-hugenn14	86	33	which	which	WDT
cord-337365-hugenn14	86	34	promotes	promote	VBZ
cord-337365-hugenn14	86	35	IFN	IFN	NNP
cord-337365-hugenn14	86	36	-	-	HYPH
cord-337365-hugenn14	86	37	β	β	NN
cord-337365-hugenn14	86	38	production	production	NN
cord-337365-hugenn14	86	39	[	[	-LRB-
cord-337365-hugenn14	86	40	8	8	CD
cord-337365-hugenn14	86	41	,	,	,
cord-337365-hugenn14	86	42	20	20	CD
cord-337365-hugenn14	86	43	]	]	-RRB-
cord-337365-hugenn14	86	44	.	.	.
cord-337365-hugenn14	87	1	Different	different	JJ
cord-337365-hugenn14	87	2	types	type	NNS
cord-337365-hugenn14	87	3	of	of	IN
cord-337365-hugenn14	87	4	PRRs	prr	NNS
cord-337365-hugenn14	87	5	can	can	MD
cord-337365-hugenn14	87	6	be	be	VB
cord-337365-hugenn14	87	7	involved	involve	VBN
cord-337365-hugenn14	87	8	in	in	IN
cord-337365-hugenn14	87	9	the	the	DT
cord-337365-hugenn14	87	10	identification	identification	NN
cord-337365-hugenn14	87	11	of	of	IN
cord-337365-hugenn14	87	12	viral	viral	JJ
cord-337365-hugenn14	87	13	infections	infection	NNS
cord-337365-hugenn14	87	14	,	,	,
cord-337365-hugenn14	87	15	including	include	VBG
cord-337365-hugenn14	87	16	membrane	membrane	NN
cord-337365-hugenn14	87	17	-	-	HYPH
cord-337365-hugenn14	87	18	associated	associate	VBN
cord-337365-hugenn14	87	19	TLRs	TLRs	NNP
cord-337365-hugenn14	87	20	,	,	,
cord-337365-hugenn14	87	21	cytosolic	cytosolic	JJ
cord-337365-hugenn14	87	22	RNA	RNA	NNP
cord-337365-hugenn14	87	23	-	-	HYPH
cord-337365-hugenn14	87	24	sensing	sense	VBG
cord-337365-hugenn14	87	25	RIG	rig	NN
cord-337365-hugenn14	87	26	-	-	HYPH
cord-337365-hugenn14	87	27	like	like	JJ
cord-337365-hugenn14	87	28	receptors	receptor	NNS
cord-337365-hugenn14	87	29	(	(	-LRB-
cord-337365-hugenn14	87	30	RLRs	RLRs	NNP
cord-337365-hugenn14	87	31	)	)	-RRB-
cord-337365-hugenn14	87	32	,	,	,
cord-337365-hugenn14	87	33	and	and	CC
cord-337365-hugenn14	87	34	DNA	dna	NN
cord-337365-hugenn14	87	35	sensors	sensor	NNS
cord-337365-hugenn14	87	36	.	.	.
cord-337365-hugenn14	88	1	PRRS	PRRS	NNP
cord-337365-hugenn14	88	2	activates	activate	VBZ
cord-337365-hugenn14	88	3	IFN	IFN	NNP
cord-337365-hugenn14	88	4	regulatory	regulatory	JJ
cord-337365-hugenn14	88	5	factors	factor	NNS
cord-337365-hugenn14	88	6	3	3	CD
cord-337365-hugenn14	88	7	(	(	-LRB-
cord-337365-hugenn14	88	8	IRF3	IRF3	NNP
cord-337365-hugenn14	88	9	)	)	-RRB-
cord-337365-hugenn14	88	10	through	through	IN
cord-337365-hugenn14	88	11	unique	unique	JJ
cord-337365-hugenn14	88	12	adaptor	adaptor	NN
cord-337365-hugenn14	88	13	molecules	molecule	NNS
cord-337365-hugenn14	88	14	such	such	JJ
cord-337365-hugenn14	88	15	as	as	IN
cord-337365-hugenn14	88	16	TIR	TIR	NNP
cord-337365-hugenn14	88	17	domain	domain	NN
cord-337365-hugenn14	88	18	-	-	HYPH
cord-337365-hugenn14	88	19	containing	contain	VBG
cord-337365-hugenn14	88	20	adaptor	adaptor	NN
cord-337365-hugenn14	88	21	inducing	induce	VBG
cord-337365-hugenn14	88	22	IFN	IFN	NNP
cord-337365-hugenn14	88	23	-	-	HYPH
cord-337365-hugenn14	88	24	β	β	NNP
cord-337365-hugenn14	88	25	(	(	-LRB-
cord-337365-hugenn14	88	26	TRIF	TRIF	NNP
cord-337365-hugenn14	88	27	)	)	-RRB-
cord-337365-hugenn14	88	28	,	,	.
cord-337365-hugenn14	89	1	mitochondrial	mitochondrial	JJ
cord-337365-hugenn14	89	2	antiviral	antiviral	JJ
cord-337365-hugenn14	89	3	signaling	signaling	NN
cord-337365-hugenn14	89	4	(	(	-LRB-
cord-337365-hugenn14	89	5	MAVS	MAVS	NNP
cord-337365-hugenn14	89	6	)	)	-RRB-
cord-337365-hugenn14	89	7	,	,	,
cord-337365-hugenn14	89	8	and	and	CC
cord-337365-hugenn14	89	9	stimulator	stimulator	NN
cord-337365-hugenn14	89	10	of	of	IN
cord-337365-hugenn14	89	11	type	type	NN
cord-337365-hugenn14	90	1	I	-PRON-	PRP
cord-337365-hugenn14	90	2	IFN	IFN	NNP
cord-337365-hugenn14	90	3	genes	gene	NNS
cord-337365-hugenn14	90	4	(	(	-LRB-
cord-337365-hugenn14	90	5	STING	sting	NN
cord-337365-hugenn14	90	6	)	)	-RRB-
cord-337365-hugenn14	91	1	[	[	-LRB-
cord-337365-hugenn14	91	2	21	21	CD
cord-337365-hugenn14	91	3	]	]	-RRB-
cord-337365-hugenn14	91	4	.	.	.
cord-337365-hugenn14	92	1	Mutations	mutation	NNS
cord-337365-hugenn14	92	2	in	in	IN
cord-337365-hugenn14	92	3	the	the	DT
cord-337365-hugenn14	92	4	IRF3	IRF3	NNP
cord-337365-hugenn14	92	5	gene	gene	NN
cord-337365-hugenn14	92	6	in	in	IN
cord-337365-hugenn14	92	7	herpes	herpes	NN
cord-337365-hugenn14	92	8	simplex	simplex	NNP
cord-337365-hugenn14	92	9	encephalitis	encephalitis	RB
cord-337365-hugenn14	93	1	(	(	-LRB-
cord-337365-hugenn14	93	2	HSE	HSE	NNP
cord-337365-hugenn14	93	3	)	)	-RRB-
cord-337365-hugenn14	93	4	patients	patient	NNS
cord-337365-hugenn14	93	5	impaired	impair	VBD
cord-337365-hugenn14	94	1	interferon	interferon	NN
cord-337365-hugenn14	94	2	production	production	NN
cord-337365-hugenn14	94	3	and	and	CC
cord-337365-hugenn14	94	4	the	the	DT
cord-337365-hugenn14	94	5	TLR3-TRIF	tlr3-trif	NN
cord-337365-hugenn14	94	6	pathway	pathway	NN
cord-337365-hugenn14	94	7	is	be	VBZ
cord-337365-hugenn14	94	8	the	the	DT
cord-337365-hugenn14	94	9	most	most	RBS
cord-337365-hugenn14	94	10	severely	severely	RB
cord-337365-hugenn14	94	11	damaged	damage	VBN
cord-337365-hugenn14	94	12	[	[	-LRB-
cord-337365-hugenn14	94	13	22	22	CD
cord-337365-hugenn14	94	14	]	]	-RRB-
cord-337365-hugenn14	94	15	.	.	.
cord-337365-hugenn14	95	1	The	the	DT
cord-337365-hugenn14	95	2	cGAS	cgas	NN
cord-337365-hugenn14	95	3	-	-	HYPH
cord-337365-hugenn14	95	4	STING	sting	NN
cord-337365-hugenn14	95	5	and	and	CC
cord-337365-hugenn14	95	6	TLR3-TRIF	tlr3-trif	NN
cord-337365-hugenn14	95	7	pathways	pathway	NNS
cord-337365-hugenn14	95	8	are	be	VBP
cord-337365-hugenn14	95	9	the	the	DT
cord-337365-hugenn14	95	10	major	major	JJ
cord-337365-hugenn14	95	11	intrinsic	intrinsic	JJ
cord-337365-hugenn14	95	12	sensing	sensing	NN
cord-337365-hugenn14	95	13	pathways	pathway	NNS
cord-337365-hugenn14	95	14	to	to	TO
cord-337365-hugenn14	95	15	control	control	VB
cord-337365-hugenn14	95	16	HSV1	hsv1	JJ
cord-337365-hugenn14	95	17	infection	infection	NN
cord-337365-hugenn14	95	18	in	in	IN
cord-337365-hugenn14	95	19	the	the	DT
cord-337365-hugenn14	95	20	CNS	CNS	NNP
cord-337365-hugenn14	95	21	.	.	.
cord-337365-hugenn14	96	1	Microglia	Microglia	NNP
cord-337365-hugenn14	96	2	can	can	MD
cord-337365-hugenn14	96	3	induce	induce	VB
cord-337365-hugenn14	96	4	IFN	IFN	NNP
cord-337365-hugenn14	96	5	responses	response	NNS
cord-337365-hugenn14	96	6	by	by	IN
cord-337365-hugenn14	96	7	recognizing	recognize	VBG
cord-337365-hugenn14	96	8	viral	viral	JJ
cord-337365-hugenn14	96	9	pathogen	pathogen	NN
cord-337365-hugenn14	96	10	-	-	HYPH
cord-337365-hugenn14	96	11	associated	associate	VBN
cord-337365-hugenn14	96	12	molecular	molecular	JJ
cord-337365-hugenn14	96	13	patterns	pattern	NNS
cord-337365-hugenn14	96	14	(	(	-LRB-
cord-337365-hugenn14	96	15	PAMPs	PAMPs	NNP
cord-337365-hugenn14	96	16	)	)	-RRB-
cord-337365-hugenn14	96	17	through	through	IN
cord-337365-hugenn14	96	18	PRRs	prr	NNS
cord-337365-hugenn14	96	19	.	.	.
cord-337365-hugenn14	97	1	In	in	IN
cord-337365-hugenn14	97	2	a	a	DT
cord-337365-hugenn14	97	3	typical	typical	JJ
cord-337365-hugenn14	97	4	IFN-1	IFN-1	NNP
cord-337365-hugenn14	97	5	response	response	NN
cord-337365-hugenn14	97	6	pattern	pattern	NN
cord-337365-hugenn14	97	7	,	,	,
cord-337365-hugenn14	97	8	PRRs	PRRs	NNP
cord-337365-hugenn14	97	9	first	first	RB
cord-337365-hugenn14	97	10	induce	induce	VBP
cord-337365-hugenn14	97	11	the	the	DT
cord-337365-hugenn14	97	12	production	production	NN
cord-337365-hugenn14	97	13	of	of	IN
cord-337365-hugenn14	97	14	IFN	IFN	NNP
cord-337365-hugenn14	97	15	-	-	HYPH
cord-337365-hugenn14	97	16	β	β	NNP
cord-337365-hugenn14	97	17	after	after	IN
cord-337365-hugenn14	97	18	recognition	recognition	NN
cord-337365-hugenn14	97	19	of	of	IN
cord-337365-hugenn14	97	20	PAMPs	pamp	NNS
cord-337365-hugenn14	97	21	,	,	,
cord-337365-hugenn14	97	22	and	and	CC
cord-337365-hugenn14	97	23	then	then	RB
cord-337365-hugenn14	97	24	IFN	IFN	NNP
cord-337365-hugenn14	97	25	-	-	HYPH
cord-337365-hugenn14	97	26	β	β	NNP
cord-337365-hugenn14	97	27	binds	bind	VBZ
cord-337365-hugenn14	97	28	to	to	IN
cord-337365-hugenn14	97	29	IFN	IFN	NNP
cord-337365-hugenn14	97	30	-	-	HYPH
cord-337365-hugenn14	97	31	α	α	NNP
cord-337365-hugenn14	97	32	receptor	receptor	NN
cord-337365-hugenn14	98	1	(	(	-LRB-
cord-337365-hugenn14	98	2	IFNαR	ifnαr	NN
cord-337365-hugenn14	98	3	)	)	-RRB-
cord-337365-hugenn14	98	4	to	to	TO
cord-337365-hugenn14	98	5	initiate	initiate	VB
cord-337365-hugenn14	98	6	IRF7	IRF7	NNP
cord-337365-hugenn14	98	7	gene	gene	NN
cord-337365-hugenn14	98	8	expression	expression	NN
cord-337365-hugenn14	98	9	in	in	IN
cord-337365-hugenn14	98	10	an	an	DT
cord-337365-hugenn14	98	11	autocrine	autocrine	JJ
cord-337365-hugenn14	98	12	or	or	CC
cord-337365-hugenn14	98	13	paracrine	paracrine	JJ
cord-337365-hugenn14	98	14	manner	manner	NN
cord-337365-hugenn14	98	15	which	which	WDT
cord-337365-hugenn14	98	16	enables	enable	VBZ
cord-337365-hugenn14	98	17	a	a	DT
cord-337365-hugenn14	98	18	complete	complete	JJ
cord-337365-hugenn14	98	19	IFN-1	IFN-1	NNP
cord-337365-hugenn14	98	20	response	response	NN
cord-337365-hugenn14	98	21	in	in	IN
cord-337365-hugenn14	98	22	viral	viral	JJ
cord-337365-hugenn14	98	23	spread	spread	NN
cord-337365-hugenn14	98	24	or	or	CC
cord-337365-hugenn14	98	25	secondary	secondary	JJ
cord-337365-hugenn14	98	26	infections	infection	NNS
cord-337365-hugenn14	98	27	[	[	-LRB-
cord-337365-hugenn14	98	28	23	23	CD
cord-337365-hugenn14	98	29	]	]	-RRB-
cord-337365-hugenn14	98	30	.	.	.
cord-337365-hugenn14	99	1	In	in	IN
cord-337365-hugenn14	99	2	order	order	NN
cord-337365-hugenn14	99	3	to	to	TO
cord-337365-hugenn14	99	4	simulate	simulate	VB
cord-337365-hugenn14	99	5	the	the	DT
cord-337365-hugenn14	99	6	natural	natural	JJ
cord-337365-hugenn14	99	7	pathway	pathway	NN
cord-337365-hugenn14	99	8	of	of	IN
cord-337365-hugenn14	99	9	HSV-1	HSV-1	NNP
cord-337365-hugenn14	99	10	entering	enter	VBG
cord-337365-hugenn14	99	11	the	the	DT
cord-337365-hugenn14	99	12	central	central	JJ
cord-337365-hugenn14	99	13	nervous	nervous	JJ
cord-337365-hugenn14	99	14	system	system	NN
cord-337365-hugenn14	99	15	by	by	IN
cord-337365-hugenn14	99	16	retrograde	retrograde	JJ
cord-337365-hugenn14	99	17	transport	transport	NN
cord-337365-hugenn14	99	18	,	,	,
cord-337365-hugenn14	99	19	the	the	DT
cord-337365-hugenn14	99	20	previous	previous	JJ
cord-337365-hugenn14	99	21	experiment	experiment	NN
cord-337365-hugenn14	99	22	used	use	VBD
cord-337365-hugenn14	99	23	an	an	DT
cord-337365-hugenn14	99	24	ocular	ocular	JJ
cord-337365-hugenn14	99	25	infection	infection	NN
cord-337365-hugenn14	99	26	model	model	NN
cord-337365-hugenn14	99	27	.	.	.
cord-337365-hugenn14	100	1	It	-PRON-	PRP
cord-337365-hugenn14	100	2	was	be	VBD
cord-337365-hugenn14	100	3	confirmed	confirm	VBN
cord-337365-hugenn14	100	4	that	that	IN
cord-337365-hugenn14	100	5	microglia	microglia	NNS
cord-337365-hugenn14	100	6	are	be	VBP
cord-337365-hugenn14	100	7	the	the	DT
cord-337365-hugenn14	100	8	main	main	JJ
cord-337365-hugenn14	100	9	source	source	NN
cord-337365-hugenn14	100	10	of	of	IN
cord-337365-hugenn14	100	11	HSV	HSV	NNP
cord-337365-hugenn14	100	12	-	-	HYPH
cord-337365-hugenn14	100	13	induced	induce	VBN
cord-337365-hugenn14	100	14	IFN-1	IFN-1	NNP
cord-337365-hugenn14	100	15	,	,	,
cord-337365-hugenn14	100	16	which	which	WDT
cord-337365-hugenn14	100	17	is	be	VBZ
cord-337365-hugenn14	100	18	induced	induce	VBN
cord-337365-hugenn14	100	19	in	in	IN
cord-337365-hugenn14	100	20	a	a	DT
cord-337365-hugenn14	100	21	cGAS	cgas	JJ
cord-337365-hugenn14	100	22	-	-	HYPH
cord-337365-hugenn14	100	23	STING	sting	NN
cord-337365-hugenn14	100	24	-	-	HYPH
cord-337365-hugenn14	100	25	dependent	dependent	JJ
cord-337365-hugenn14	100	26	manner	manner	NN
cord-337365-hugenn14	100	27	.	.	.
cord-337365-hugenn14	101	1	Infected	infected	JJ
cord-337365-hugenn14	101	2	cells	cell	NNS
cord-337365-hugenn14	101	3	including	include	VBG
cord-337365-hugenn14	101	4	neurons	neuron	NNS
cord-337365-hugenn14	101	5	and	and	CC
cord-337365-hugenn14	101	6	microglia	microglia	NN
cord-337365-hugenn14	101	7	detected	detect	VBD
cord-337365-hugenn14	101	8	HSV-1	hsv-1	NN
cord-337365-hugenn14	101	9	by	by	IN
cord-337365-hugenn14	101	10	the	the	DT
cord-337365-hugenn14	101	11	cytoplasmic	cytoplasmic	JJ
cord-337365-hugenn14	101	12	DNA	dna	NN
cord-337365-hugenn14	101	13	receptor	receptor	NN
cord-337365-hugenn14	101	14	,	,	,
cord-337365-hugenn14	101	15	the	the	DT
cord-337365-hugenn14	101	16	adaptor	adaptor	NN
cord-337365-hugenn14	101	17	protein	protein	NN
cord-337365-hugenn14	101	18	STING	STING	NNP
cord-337365-hugenn14	101	19	.	.	.
cord-337365-hugenn14	102	1	The	the	DT
cord-337365-hugenn14	102	2	brain	brain	NN
cord-337365-hugenn14	102	3	of	of	IN
cord-337365-hugenn14	102	4	mice	mouse	NNS
cord-337365-hugenn14	102	5	lacking	lack	VBG
cord-337365-hugenn14	102	6	cGAS	cgas	NN
cord-337365-hugenn14	102	7	and	and	CC
cord-337365-hugenn14	102	8	STING	sting	NN
cord-337365-hugenn14	102	9	detected	detect	VBD
cord-337365-hugenn14	102	10	higher	high	JJR
cord-337365-hugenn14	102	11	viral	viral	JJ
cord-337365-hugenn14	102	12	load	load	NN
cord-337365-hugenn14	102	13	,	,	,
cord-337365-hugenn14	102	14	and	and	CC
cord-337365-hugenn14	102	15	the	the	DT
cord-337365-hugenn14	102	16	virus	virus	NN
cord-337365-hugenn14	102	17	spread	spread	VBD
cord-337365-hugenn14	102	18	widely	widely	RB
cord-337365-hugenn14	102	19	to	to	IN
cord-337365-hugenn14	102	20	the	the	DT
cord-337365-hugenn14	102	21	midbrain	midbrain	NN
cord-337365-hugenn14	102	22	,	,	,
cord-337365-hugenn14	102	23	hypothalamus	hypothalamus	NN
cord-337365-hugenn14	102	24	,	,	,
cord-337365-hugenn14	102	25	and	and	CC
cord-337365-hugenn14	102	26	preoptic	preoptic	JJ
cord-337365-hugenn14	102	27	area	area	NN
cord-337365-hugenn14	102	28	.	.	.
cord-337365-hugenn14	103	1	However	however	RB
cord-337365-hugenn14	103	2	,	,	,
cord-337365-hugenn14	103	3	studies	study	NNS
cord-337365-hugenn14	103	4	have	have	VBP
cord-337365-hugenn14	103	5	shown	show	VBN
cord-337365-hugenn14	103	6	that	that	IN
cord-337365-hugenn14	103	7	the	the	DT
cord-337365-hugenn14	103	8	recruitment	recruitment	NN
cord-337365-hugenn14	103	9	of	of	IN
cord-337365-hugenn14	103	10	microglia	microglia	NNP
cord-337365-hugenn14	103	11	to	to	IN
cord-337365-hugenn14	103	12	the	the	DT
cord-337365-hugenn14	103	13	infection	infection	NN
cord-337365-hugenn14	103	14	site	site	NN
cord-337365-hugenn14	103	15	is	be	VBZ
cord-337365-hugenn14	103	16	not	not	RB
cord-337365-hugenn14	103	17	related	relate	VBN
cord-337365-hugenn14	103	18	to	to	IN
cord-337365-hugenn14	103	19	STING	sting	VB
cord-337365-hugenn14	103	20	[	[	-LRB-
cord-337365-hugenn14	103	21	24	24	CD
cord-337365-hugenn14	103	22	]	]	-RRB-
cord-337365-hugenn14	103	23	.	.	.
cord-337365-hugenn14	104	1	In	in	IN
cord-337365-hugenn14	104	2	a	a	DT
cord-337365-hugenn14	104	3	model	model	NN
cord-337365-hugenn14	104	4	of	of	IN
cord-337365-hugenn14	104	5	MHV	MHV	NNP
cord-337365-hugenn14	104	6	infection	infection	NN
cord-337365-hugenn14	104	7	,	,	,
cord-337365-hugenn14	104	8	depletion	depletion	NN
cord-337365-hugenn14	104	9	of	of	IN
cord-337365-hugenn14	104	10	microglia	microglia	NN
cord-337365-hugenn14	104	11	using	use	VBG
cord-337365-hugenn14	104	12	colony	colony	NN
cord-337365-hugenn14	104	13	-	-	HYPH
cord-337365-hugenn14	104	14	stimulating	stimulate	VBG
cord-337365-hugenn14	104	15	factor	factor	NN
cord-337365-hugenn14	104	16	1	1	CD
cord-337365-hugenn14	104	17	receptor	receptor	NN
cord-337365-hugenn14	104	18	(	(	-LRB-
cord-337365-hugenn14	104	19	CSF1R	CSF1R	NNS
cord-337365-hugenn14	104	20	)	)	-RRB-
cord-337365-hugenn14	105	1	inhibitors	inhibitor	NNS
cord-337365-hugenn14	105	2	revealed	reveal	VBD
cord-337365-hugenn14	105	3	that	that	IN
cord-337365-hugenn14	105	4	depletion	depletion	NN
cord-337365-hugenn14	105	5	of	of	IN
cord-337365-hugenn14	105	6	microglia	microglia	NNS
cord-337365-hugenn14	105	7	at	at	IN
cord-337365-hugenn14	105	8	0	0	CD
cord-337365-hugenn14	105	9	-	-	SYM
cord-337365-hugenn14	105	10	6	6	CD
cord-337365-hugenn14	105	11	days	day	NNS
cord-337365-hugenn14	105	12	of	of	IN
cord-337365-hugenn14	105	13	infection	infection	NN
cord-337365-hugenn14	105	14	would	would	MD
cord-337365-hugenn14	105	15	result	result	VB
cord-337365-hugenn14	105	16	in	in	IN
cord-337365-hugenn14	105	17	increased	increase	VBN
cord-337365-hugenn14	105	18	mortality	mortality	NN
cord-337365-hugenn14	105	19	and	and	CC
cord-337365-hugenn14	105	20	a	a	DT
cord-337365-hugenn14	105	21	later	later	JJ
cord-337365-hugenn14	105	22	depletion	depletion	NN
cord-337365-hugenn14	105	23	had	have	VBD
cord-337365-hugenn14	105	24	no	no	DT
cord-337365-hugenn14	105	25	influences	influence	NNS
cord-337365-hugenn14	105	26	on	on	IN
cord-337365-hugenn14	105	27	survival	survival	NN
cord-337365-hugenn14	105	28	.	.	.
cord-337365-hugenn14	106	1	It	-PRON-	PRP
cord-337365-hugenn14	106	2	indicated	indicate	VBD
cord-337365-hugenn14	106	3	that	that	IN
cord-337365-hugenn14	106	4	microglia	microglia	NNS
cord-337365-hugenn14	106	5	play	play	VBP
cord-337365-hugenn14	106	6	an	an	DT
cord-337365-hugenn14	106	7	important	important	JJ
cord-337365-hugenn14	106	8	role	role	NN
cord-337365-hugenn14	106	9	in	in	IN
cord-337365-hugenn14	106	10	controlling	control	VBG
cord-337365-hugenn14	106	11	viral	viral	JJ
cord-337365-hugenn14	106	12	replication	replication	NN
cord-337365-hugenn14	106	13	and	and	CC
cord-337365-hugenn14	106	14	reducing	reduce	VBG
cord-337365-hugenn14	106	15	mortality	mortality	NN
cord-337365-hugenn14	106	16	in	in	IN
cord-337365-hugenn14	106	17	the	the	DT
cord-337365-hugenn14	106	18	early	early	JJ
cord-337365-hugenn14	106	19	stage	stage	NN
cord-337365-hugenn14	106	20	of	of	IN
cord-337365-hugenn14	106	21	infection	infection	NN
cord-337365-hugenn14	106	22	[	[	-LRB-
cord-337365-hugenn14	106	23	14	14	CD
cord-337365-hugenn14	106	24	]	]	-RRB-
cord-337365-hugenn14	106	25	.	.	.
cord-337365-hugenn14	107	1	Upon	upon	IN
cord-337365-hugenn14	107	2	intranasal	intranasal	NN
cord-337365-hugenn14	107	3	vesicular	vesicular	JJ
cord-337365-hugenn14	107	4	stomatitis	stomatitis	NN
cord-337365-hugenn14	107	5	virus	virus	NN
cord-337365-hugenn14	107	6	(	(	-LRB-
cord-337365-hugenn14	107	7	VSV	VSV	NNP
cord-337365-hugenn14	107	8	)	)	-RRB-
cord-337365-hugenn14	107	9	infection	infection	NN
cord-337365-hugenn14	107	10	,	,	,
cord-337365-hugenn14	107	11	studies	study	NNS
cord-337365-hugenn14	107	12	have	have	VBP
cord-337365-hugenn14	107	13	found	find	VBN
cord-337365-hugenn14	107	14	activated	activate	VBN
cord-337365-hugenn14	107	15	microglia	microglia	NNS
cord-337365-hugenn14	107	16	and	and	CC
cord-337365-hugenn14	107	17	monocyte	monocyte	NNP
cord-337365-hugenn14	107	18	aggregation	aggregation	NN
cord-337365-hugenn14	107	19	in	in	IN
cord-337365-hugenn14	107	20	the	the	DT
cord-337365-hugenn14	107	21	olfactory	olfactory	JJ
cord-337365-hugenn14	107	22	bulb	bulb	NN
cord-337365-hugenn14	107	23	.	.	.
cord-337365-hugenn14	108	1	Studies	study	NNS
cord-337365-hugenn14	108	2	have	have	VBP
cord-337365-hugenn14	108	3	also	also	RB
cord-337365-hugenn14	108	4	shown	show	VBN
cord-337365-hugenn14	108	5	that	that	IN
cord-337365-hugenn14	108	6	microglia	microglia	NN
cord-337365-hugenn14	108	7	accumulating	accumulate	VBG
cord-337365-hugenn14	108	8	around	around	IN
cord-337365-hugenn14	108	9	the	the	DT
cord-337365-hugenn14	108	10	olfactory	olfactory	JJ
cord-337365-hugenn14	108	11	bulb	bulb	NN
cord-337365-hugenn14	108	12	form	form	NN
cord-337365-hugenn14	108	13	a	a	DT
cord-337365-hugenn14	108	14	natural	natural	JJ
cord-337365-hugenn14	108	15	immune	immune	JJ
cord-337365-hugenn14	108	16	barrier	barrier	NN
cord-337365-hugenn14	108	17	plays	play	VBZ
cord-337365-hugenn14	108	18	an	an	DT
cord-337365-hugenn14	108	19	important	important	JJ
cord-337365-hugenn14	108	20	role	role	NN
cord-337365-hugenn14	108	21	in	in	IN
cord-337365-hugenn14	108	22	limiting	limit	VBG
cord-337365-hugenn14	108	23	the	the	DT
cord-337365-hugenn14	108	24	spread	spread	NN
cord-337365-hugenn14	108	25	of	of	IN
cord-337365-hugenn14	108	26	VSV	VSV	NNP
cord-337365-hugenn14	108	27	in	in	IN
cord-337365-hugenn14	108	28	the	the	DT
cord-337365-hugenn14	108	29	CNS	CNS	NNP
cord-337365-hugenn14	108	30	and	and	CC
cord-337365-hugenn14	108	31	preventing	prevent	VBG
cord-337365-hugenn14	108	32	lethal	lethal	JJ
cord-337365-hugenn14	108	33	encephalitis	encephalitis	RB
cord-337365-hugenn14	108	34	.	.	.
cord-337365-hugenn14	109	1	The	the	DT
cord-337365-hugenn14	109	2	formation	formation	NN
cord-337365-hugenn14	109	3	of	of	IN
cord-337365-hugenn14	109	4	the	the	DT
cord-337365-hugenn14	109	5	intrinsic	intrinsic	JJ
cord-337365-hugenn14	109	6	microglia	microglia	JJ
cord-337365-hugenn14	109	7	barrier	barrier	NN
cord-337365-hugenn14	109	8	is	be	VBZ
cord-337365-hugenn14	109	9	regulated	regulate	VBN
cord-337365-hugenn14	109	10	by	by	IN
cord-337365-hugenn14	109	11	IFNAR	IFNAR	NNP
cord-337365-hugenn14	109	12	signaling	signaling	NN
cord-337365-hugenn14	109	13	of	of	IN
cord-337365-hugenn14	109	14	neurons	neuron	NNS
cord-337365-hugenn14	109	15	and	and	CC
cord-337365-hugenn14	109	16	astrocytes	astrocyte	NNS
cord-337365-hugenn14	109	17	and	and	CC
cord-337365-hugenn14	109	18	is	be	VBZ
cord-337365-hugenn14	109	19	not	not	RB
cord-337365-hugenn14	109	20	regulated	regulate	VBN
cord-337365-hugenn14	109	21	by	by	IN
cord-337365-hugenn14	109	22	microglia	microglia	NNS
cord-337365-hugenn14	109	23	themselves	-PRON-	PRP
cord-337365-hugenn14	109	24	[	[	-LRB-
cord-337365-hugenn14	109	25	25	25	CD
cord-337365-hugenn14	109	26	]	]	-RRB-
cord-337365-hugenn14	109	27	.	.	.
cord-337365-hugenn14	110	1	It	-PRON-	PRP
cord-337365-hugenn14	110	2	has	have	VBZ
cord-337365-hugenn14	110	3	been	be	VBN
cord-337365-hugenn14	110	4	previously	previously	RB
cord-337365-hugenn14	110	5	reported	report	VBN
cord-337365-hugenn14	110	6	that	that	IN
cord-337365-hugenn14	110	7	the	the	DT
cord-337365-hugenn14	110	8	use	use	NN
cord-337365-hugenn14	110	9	of	of	IN
cord-337365-hugenn14	110	10	brain	brain	NN
cord-337365-hugenn14	110	11	-	-	HYPH
cord-337365-hugenn14	110	12	penetrant	penetrant	JJ
cord-337365-hugenn14	110	13	CSF-1R	csf-1r	JJ
cord-337365-hugenn14	110	14	inhibitor	inhibitor	NN
cord-337365-hugenn14	110	15	BLZ945	BLZ945	NNP
cord-337365-hugenn14	110	16	in	in	IN
cord-337365-hugenn14	110	17	mice	mouse	NNS
cord-337365-hugenn14	110	18	can	can	MD
cord-337365-hugenn14	110	19	remove	remove	VB
cord-337365-hugenn14	110	20	microglia	microglia	NNS
cord-337365-hugenn14	110	21	[	[	-LRB-
cord-337365-hugenn14	110	22	26	26	CD
cord-337365-hugenn14	110	23	]	]	-RRB-
cord-337365-hugenn14	110	24	.	.	.
cord-337365-hugenn14	111	1	IL-34	IL-34	NNP
cord-337365-hugenn14	111	2	,	,	,
cord-337365-hugenn14	111	3	as	as	IN
cord-337365-hugenn14	111	4	a	a	DT
cord-337365-hugenn14	111	5	CSF-1R	CSF-1R	NNP
cord-337365-hugenn14	111	6	ligand	ligand	NN
cord-337365-hugenn14	111	7	,	,	,
cord-337365-hugenn14	111	8	is	be	VBZ
cord-337365-hugenn14	111	9	essential	essential	JJ
cord-337365-hugenn14	111	10	for	for	IN
cord-337365-hugenn14	111	11	the	the	DT
cord-337365-hugenn14	111	12	maintenance	maintenance	NN
cord-337365-hugenn14	111	13	of	of	IN
cord-337365-hugenn14	111	14	microglia	microglia	NNP
cord-337365-hugenn14	111	15	.	.	.
cord-337365-hugenn14	112	1	BLZ945	BLZ945	NNP
cord-337365-hugenn14	112	2	plays	play	VBZ
cord-337365-hugenn14	112	3	a	a	DT
cord-337365-hugenn14	112	4	role	role	NN
cord-337365-hugenn14	112	5	in	in	IN
cord-337365-hugenn14	112	6	specifically	specifically	RB
cord-337365-hugenn14	112	7	depleting	deplete	VBG
cord-337365-hugenn14	112	8	microglia	microglia	NNS
cord-337365-hugenn14	112	9	by	by	IN
cord-337365-hugenn14	112	10	inhibiting	inhibit	VBG
cord-337365-hugenn14	112	11	the	the	DT
cord-337365-hugenn14	112	12	interaction	interaction	NN
cord-337365-hugenn14	112	13	of	of	IN
cord-337365-hugenn14	112	14	CSF-1R	CSF-1R	NNP
cord-337365-hugenn14	112	15	with	with	IN
cord-337365-hugenn14	112	16	IL-34	IL-34	NNP
cord-337365-hugenn14	112	17	[	[	-LRB-
cord-337365-hugenn14	112	18	27	27	CD
cord-337365-hugenn14	112	19	]	]	-RRB-
cord-337365-hugenn14	112	20	.	.	.
cord-337365-hugenn14	113	1	After	after	IN
cord-337365-hugenn14	113	2	depletion	depletion	NN
cord-337365-hugenn14	113	3	of	of	IN
cord-337365-hugenn14	113	4	microglia	microglia	NN
cord-337365-hugenn14	113	5	,	,	,
cord-337365-hugenn14	113	6	VSV	VSV	NNP
cord-337365-hugenn14	113	7	-	-	HYPH
cord-337365-hugenn14	113	8	infected	infect	VBN
cord-337365-hugenn14	113	9	mice	mouse	NNS
cord-337365-hugenn14	113	10	have	have	VBP
cord-337365-hugenn14	113	11	higher	high	JJR
cord-337365-hugenn14	113	12	viral	viral	JJ
cord-337365-hugenn14	113	13	load	load	NN
cord-337365-hugenn14	113	14	in	in	IN
cord-337365-hugenn14	113	15	the	the	DT
cord-337365-hugenn14	113	16	brain	brain	NN
cord-337365-hugenn14	113	17	,	,	,
cord-337365-hugenn14	113	18	cerebellum	cerebellum	NN
cord-337365-hugenn14	113	19	,	,	,
cord-337365-hugenn14	113	20	and	and	CC
cord-337365-hugenn14	113	21	brainstem	brainstem	NN
cord-337365-hugenn14	113	22	and	and	CC
cord-337365-hugenn14	113	23	have	have	VBP
cord-337365-hugenn14	113	24	higher	high	JJR
cord-337365-hugenn14	113	25	mortality	mortality	NN
cord-337365-hugenn14	113	26	,	,	,
cord-337365-hugenn14	113	27	indicating	indicate	VBG
cord-337365-hugenn14	113	28	that	that	IN
cord-337365-hugenn14	113	29	the	the	DT
cord-337365-hugenn14	113	30	formation	formation	NN
cord-337365-hugenn14	113	31	of	of	IN
cord-337365-hugenn14	113	32	microglia	microglia	JJ
cord-337365-hugenn14	113	33	barrier	barrier	NN
cord-337365-hugenn14	113	34	in	in	IN
cord-337365-hugenn14	113	35	the	the	DT
cord-337365-hugenn14	113	36	olfactory	olfactory	JJ
cord-337365-hugenn14	113	37	bulb	bulb	NN
cord-337365-hugenn14	113	38	is	be	VBZ
cord-337365-hugenn14	113	39	indispensable	indispensable	JJ
cord-337365-hugenn14	113	40	to	to	TO
cord-337365-hugenn14	113	41	limit	limit	VB
cord-337365-hugenn14	113	42	the	the	DT
cord-337365-hugenn14	113	43	spread	spread	NN
cord-337365-hugenn14	113	44	and	and	CC
cord-337365-hugenn14	113	45	spread	spread	NN
cord-337365-hugenn14	113	46	of	of	IN
cord-337365-hugenn14	113	47	VSV	VSV	NNP
cord-337365-hugenn14	113	48	[	[	-LRB-
cord-337365-hugenn14	113	49	25	25	CD
cord-337365-hugenn14	113	50	]	]	-RRB-
cord-337365-hugenn14	113	51	.	.	.
cord-337365-hugenn14	114	1	Sall1	Sall1	NNP
cord-337365-hugenn14	114	2	is	be	VBZ
cord-337365-hugenn14	114	3	specifically	specifically	RB
cord-337365-hugenn14	114	4	expressed	express	VBN
cord-337365-hugenn14	114	5	in	in	IN
cord-337365-hugenn14	114	6	microglia	microglia	NN
cord-337365-hugenn14	114	7	and	and	CC
cord-337365-hugenn14	114	8	is	be	VBZ
cord-337365-hugenn14	114	9	a	a	DT
cord-337365-hugenn14	114	10	negative	negative	JJ
cord-337365-hugenn14	114	11	regulator	regulator	NN
cord-337365-hugenn14	114	12	of	of	IN
cord-337365-hugenn14	114	13	microglia	microglia	NNP
cord-337365-hugenn14	114	14	activation	activation	NN
cord-337365-hugenn14	114	15	.	.	.
cord-337365-hugenn14	115	1	Sall1	Sall1	NNP
cord-337365-hugenn14	115	2	is	be	VBZ
cord-337365-hugenn14	115	3	downregulated	downregulate	VBN
cord-337365-hugenn14	115	4	in	in	IN
cord-337365-hugenn14	115	5	microglia	microglia	NN
cord-337365-hugenn14	115	6	when	when	WRB
cord-337365-hugenn14	115	7	infected	infect	VBN
cord-337365-hugenn14	115	8	by	by	IN
cord-337365-hugenn14	115	9	pathogens	pathogen	NNS
cord-337365-hugenn14	115	10	,	,	,
cord-337365-hugenn14	115	11	thereby	thereby	RB
cord-337365-hugenn14	115	12	promoting	promote	VBG
cord-337365-hugenn14	115	13	microglia	microglia	JJ
cord-337365-hugenn14	115	14	activation	activation	NN
cord-337365-hugenn14	115	15	[	[	-LRB-
cord-337365-hugenn14	115	16	28	28	CD
cord-337365-hugenn14	115	17	]	]	-RRB-
cord-337365-hugenn14	115	18	.	.	.
cord-337365-hugenn14	116	1	Microglia	Microglia	NNP
cord-337365-hugenn14	116	2	confer	confer	VB
cord-337365-hugenn14	116	3	STING	sting	NN
cord-337365-hugenn14	116	4	-	-	HYPH
cord-337365-hugenn14	116	5	dependent	dependent	JJ
cord-337365-hugenn14	116	6	antiviral	antiviral	JJ
cord-337365-hugenn14	116	7	activity	activity	NN
cord-337365-hugenn14	116	8	to	to	IN
cord-337365-hugenn14	116	9	neurons	neuron	NNS
cord-337365-hugenn14	116	10	and	and	CC
cord-337365-hugenn14	116	11	initiate	initiate	VB
cord-337365-hugenn14	116	12	the	the	DT
cord-337365-hugenn14	116	13	production	production	NN
cord-337365-hugenn14	116	14	of	of	IN
cord-337365-hugenn14	116	15	IFN-1	IFN-1	NNP
cord-337365-hugenn14	116	16	in	in	IN
cord-337365-hugenn14	116	17	astrocytes	astrocyte	NNS
cord-337365-hugenn14	116	18	via	via	IN
cord-337365-hugenn14	116	19	the	the	DT
cord-337365-hugenn14	116	20	toll	toll	NN
cord-337365-hugenn14	116	21	-	-	HYPH
cord-337365-hugenn14	116	22	like	like	JJ
cord-337365-hugenn14	116	23	receptor	receptor	NN
cord-337365-hugenn14	116	24	3	3	CD
cord-337365-hugenn14	117	1	(	(	-LRB-
cord-337365-hugenn14	117	2	TLR3	TLR3	NNP
cord-337365-hugenn14	117	3	)	)	-RRB-
cord-337365-hugenn14	117	4	pathway	pathway	NN
cord-337365-hugenn14	117	5	[	[	-LRB-
cord-337365-hugenn14	117	6	24	24	CD
cord-337365-hugenn14	117	7	]	]	-RRB-
cord-337365-hugenn14	117	8	.	.	.
cord-337365-hugenn14	118	1	Type	type	NN
cord-337365-hugenn14	118	2	I	-PRON-	PRP
cord-337365-hugenn14	118	3	IFNAR	IFNAR	NNP
cord-337365-hugenn14	118	4	signaling	signal	VBG
cord-337365-hugenn14	118	5	in	in	IN
cord-337365-hugenn14	118	6	astrocytes	astrocyte	NNS
cord-337365-hugenn14	118	7	acts	act	VBZ
cord-337365-hugenn14	118	8	to	to	TO
cord-337365-hugenn14	118	9	stabilize	stabilize	VB
cord-337365-hugenn14	118	10	the	the	DT
cord-337365-hugenn14	118	11	blood	blood	NN
cord-337365-hugenn14	118	12	-	-	HYPH
cord-337365-hugenn14	118	13	brain	brain	NN
cord-337365-hugenn14	118	14	barrier	barrier	NN
cord-337365-hugenn14	118	15	(	(	-LRB-
cord-337365-hugenn14	118	16	BBB	BBB	NNP
cord-337365-hugenn14	118	17	)	)	-RRB-
cord-337365-hugenn14	118	18	and	and	CC
cord-337365-hugenn14	118	19	protect	protect	VB
cord-337365-hugenn14	118	20	the	the	DT
cord-337365-hugenn14	118	21	brain	brain	NN
cord-337365-hugenn14	118	22	from	from	IN
cord-337365-hugenn14	118	23	viral	viral	JJ
cord-337365-hugenn14	118	24	infections	infection	NNS
cord-337365-hugenn14	118	25	and	and	CC
cord-337365-hugenn14	118	26	immunopathology	immunopathology	NN
cord-337365-hugenn14	118	27	(	(	-LRB-
cord-337365-hugenn14	118	28	see	see	VB
cord-337365-hugenn14	118	29	Fig	Fig	NNP
cord-337365-hugenn14	118	30	.	.	NNP
cord-337365-hugenn14	118	31	1	1	CD
cord-337365-hugenn14	118	32	)	)	-RRB-
cord-337365-hugenn14	118	33	.	.	.
cord-337365-hugenn14	119	1	In	in	IN
cord-337365-hugenn14	119	2	a	a	DT
cord-337365-hugenn14	119	3	mouse	mouse	NN
cord-337365-hugenn14	119	4	model	model	NN
cord-337365-hugenn14	119	5	of	of	IN
cord-337365-hugenn14	119	6	West	West	NNP
cord-337365-hugenn14	119	7	Nile	Nile	NNP
cord-337365-hugenn14	119	8	virus	virus	NN
cord-337365-hugenn14	119	9	(	(	-LRB-
cord-337365-hugenn14	119	10	WNV	WNV	NNP
cord-337365-hugenn14	119	11	)	)	-RRB-
cord-337365-hugenn14	119	12	infection	infection	NN
cord-337365-hugenn14	119	13	,	,	,
cord-337365-hugenn14	119	14	it	-PRON-	PRP
cord-337365-hugenn14	119	15	was	be	VBD
cord-337365-hugenn14	119	16	found	find	VBN
cord-337365-hugenn14	119	17	that	that	IN
cord-337365-hugenn14	119	18	the	the	DT
cord-337365-hugenn14	119	19	permeability	permeability	NN
cord-337365-hugenn14	119	20	of	of	IN
cord-337365-hugenn14	119	21	the	the	DT
cord-337365-hugenn14	119	22	BBB	BBB	NNP
cord-337365-hugenn14	119	23	increased	increase	VBD
cord-337365-hugenn14	119	24	in	in	IN
cord-337365-hugenn14	119	25	mice	mouse	NNS
cord-337365-hugenn14	119	26	lacking	lack	VBG
cord-337365-hugenn14	119	27	IFNAR	IFNAR	NNP
cord-337365-hugenn14	119	28	,	,	,
cord-337365-hugenn14	119	29	especially	especially	RB
cord-337365-hugenn14	119	30	in	in	IN
cord-337365-hugenn14	119	31	the	the	DT
cord-337365-hugenn14	119	32	hindbrain	hindbrain	NNP
cord-337365-hugenn14	119	33	,	,	,
cord-337365-hugenn14	119	34	which	which	WDT
cord-337365-hugenn14	119	35	leads	lead	VBZ
cord-337365-hugenn14	119	36	to	to	IN
cord-337365-hugenn14	119	37	an	an	DT
cord-337365-hugenn14	119	38	increase	increase	NN
cord-337365-hugenn14	119	39	in	in	IN
cord-337365-hugenn14	119	40	viral	viral	JJ
cord-337365-hugenn14	119	41	entry	entry	NN
cord-337365-hugenn14	119	42	,	,	,
cord-337365-hugenn14	119	43	indicating	indicate	VBG
cord-337365-hugenn14	119	44	that	that	IN
cord-337365-hugenn14	119	45	IFNAR	IFNAR	NNP
cord-337365-hugenn14	119	46	signaling	signaling	NN
cord-337365-hugenn14	119	47	has	have	VBZ
cord-337365-hugenn14	119	48	important	important	JJ
cord-337365-hugenn14	119	49	regulatory	regulatory	JJ
cord-337365-hugenn14	119	50	effects	effect	NNS
cord-337365-hugenn14	119	51	on	on	IN
cord-337365-hugenn14	119	52	BBB	BBB	NNP
cord-337365-hugenn14	119	53	permeability	permeability	NN
cord-337365-hugenn14	119	54	in	in	IN
cord-337365-hugenn14	119	55	this	this	DT
cord-337365-hugenn14	119	56	brain	brain	NN
cord-337365-hugenn14	119	57	region	region	NN
cord-337365-hugenn14	119	58	.	.	.
cord-337365-hugenn14	120	1	The	the	DT
cord-337365-hugenn14	120	2	study	study	NN
cord-337365-hugenn14	120	3	found	find	VBD
cord-337365-hugenn14	120	4	that	that	IN
cord-337365-hugenn14	120	5	human	human	NN
cord-337365-hugenn14	120	6	and	and	CC
cord-337365-hugenn14	120	7	mouse	mouse	NN
cord-337365-hugenn14	120	8	cerebellar	cerebellar	JJ
cord-337365-hugenn14	120	9	astrocytes	astrocyte	NNS
cord-337365-hugenn14	120	10	have	have	VBP
cord-337365-hugenn14	120	11	higher	high	JJR
cord-337365-hugenn14	120	12	expression	expression	NN
cord-337365-hugenn14	120	13	of	of	IN
cord-337365-hugenn14	120	14	PRRs	prr	NNS
cord-337365-hugenn14	120	15	and	and	CC
cord-337365-hugenn14	120	16	ISGs	ISGs	NNPS
cord-337365-hugenn14	120	17	in	in	IN
cord-337365-hugenn14	120	18	both	both	DT
cord-337365-hugenn14	120	19	steady	steady	JJ
cord-337365-hugenn14	120	20	state	state	NN
cord-337365-hugenn14	120	21	and	and	CC
cord-337365-hugenn14	120	22	IFN	IFN	NNP
cord-337365-hugenn14	120	23	-	-	HYPH
cord-337365-hugenn14	120	24	induced	induce	VBN
cord-337365-hugenn14	120	25	state	state	NN
cord-337365-hugenn14	120	26	compared	compare	VBN
cord-337365-hugenn14	120	27	with	with	IN
cord-337365-hugenn14	120	28	cerebral	cerebral	JJ
cord-337365-hugenn14	120	29	cortical	cortical	JJ
cord-337365-hugenn14	120	30	astrocytes	astrocyte	NNS
cord-337365-hugenn14	120	31	.	.	.
cord-337365-hugenn14	121	1	Cerebellar	cerebellar	JJ
cord-337365-hugenn14	121	2	astrocytes	astrocyte	NNS
cord-337365-hugenn14	121	3	can	can	MD
cord-337365-hugenn14	121	4	reach	reach	VB
cord-337365-hugenn14	121	5	maximum	maximum	JJ
cord-337365-hugenn14	121	6	ISG	ISG	NNP
cord-337365-hugenn14	121	7	expression	expression	NN
cord-337365-hugenn14	121	8	more	more	RBR
cord-337365-hugenn14	121	9	quickly	quickly	RB
cord-337365-hugenn14	121	10	after	after	IN
cord-337365-hugenn14	121	11	receiving	receive	VBG
cord-337365-hugenn14	121	12	IFN	IFN	NNP
cord-337365-hugenn14	121	13	stimulation	stimulation	NN
cord-337365-hugenn14	121	14	[	[	-LRB-
cord-337365-hugenn14	121	15	29	29	CD
cord-337365-hugenn14	121	16	]	]	-RRB-
cord-337365-hugenn14	121	17	.	.	.
cord-337365-hugenn14	122	1	In	in	IN
cord-337365-hugenn14	122	2	vitro	vitro	FW
cord-337365-hugenn14	122	3	studies	study	NNS
cord-337365-hugenn14	122	4	have	have	VBP
cord-337365-hugenn14	122	5	shown	show	VBN
cord-337365-hugenn14	122	6	that	that	IN
cord-337365-hugenn14	122	7	IFNAR	IFNAR	NNP
cord-337365-hugenn14	122	8	pathways	pathway	NNS
cord-337365-hugenn14	122	9	in	in	IN
cord-337365-hugenn14	122	10	brain	brain	NN
cord-337365-hugenn14	122	11	microvascular	microvascular	JJ
cord-337365-hugenn14	122	12	endothelial	endothelial	JJ
cord-337365-hugenn14	122	13	cells	cell	NNS
cord-337365-hugenn14	122	14	(	(	-LRB-
cord-337365-hugenn14	122	15	BMECs	bmec	NNS
cord-337365-hugenn14	122	16	)	)	-RRB-
cord-337365-hugenn14	122	17	and	and	CC
cord-337365-hugenn14	122	18	astrocytes	astrocyte	NNS
cord-337365-hugenn14	122	19	can	can	MD
cord-337365-hugenn14	122	20	both	both	DT
cord-337365-hugenn14	122	21	promote	promote	VB
cord-337365-hugenn14	122	22	the	the	DT
cord-337365-hugenn14	122	23	integrity	integrity	NN
cord-337365-hugenn14	122	24	of	of	IN
cord-337365-hugenn14	122	25	tight	tight	JJ
cord-337365-hugenn14	122	26	junction	junction	NN
cord-337365-hugenn14	122	27	.	.	.
cord-337365-hugenn14	123	1	Studies	study	NNS
cord-337365-hugenn14	123	2	have	have	VBP
cord-337365-hugenn14	123	3	shown	show	VBN
cord-337365-hugenn14	123	4	that	that	IN
cord-337365-hugenn14	123	5	IFN-1	IFN-1	NNP
cord-337365-hugenn14	123	6	stabilizes	stabilize	VBZ
cord-337365-hugenn14	123	7	the	the	DT
cord-337365-hugenn14	123	8	integrity	integrity	NN
cord-337365-hugenn14	123	9	of	of	IN
cord-337365-hugenn14	123	10	BBB	BBB	NNP
cord-337365-hugenn14	123	11	and	and	CC
cord-337365-hugenn14	123	12	promotes	promote	VBZ
cord-337365-hugenn14	123	13	the	the	DT
cord-337365-hugenn14	123	14	formation	formation	NN
cord-337365-hugenn14	123	15	of	of	IN
cord-337365-hugenn14	123	16	tight	tight	JJ
cord-337365-hugenn14	123	17	junctions	junction	NNS
cord-337365-hugenn14	123	18	by	by	IN
cord-337365-hugenn14	123	19	rearranging	rearrange	VBG
cord-337365-hugenn14	123	20	endothelial	endothelial	JJ
cord-337365-hugenn14	123	21	junction	junction	NN
cord-337365-hugenn14	123	22	proteins	protein	NNS
cord-337365-hugenn14	123	23	via	via	IN
cord-337365-hugenn14	123	24	Rho	Rho	NNP
cord-337365-hugenn14	123	25	-	-	HYPH
cord-337365-hugenn14	123	26	Rac	Rac	NNP
cord-337365-hugenn14	123	27	signaling	signal	VBG
cord-337365-hugenn14	123	28	pathways	pathway	NNS
cord-337365-hugenn14	123	29	,	,	,
cord-337365-hugenn14	123	30	promoting	promote	VBG
cord-337365-hugenn14	123	31	BBB	BBB	NNP
cord-337365-hugenn14	123	32	tightening	tightening	NN
cord-337365-hugenn14	123	33	and	and	CC
cord-337365-hugenn14	123	34	blocking	block	VBG
cord-337365-hugenn14	123	35	the	the	DT
cord-337365-hugenn14	123	36	expression	expression	NN
cord-337365-hugenn14	123	37	of	of	IN
cord-337365-hugenn14	123	38	IL-1β	IL-1β	NNP
cord-337365-hugenn14	123	39	and	and	CC
cord-337365-hugenn14	123	40	TNF	TNF	NNP
cord-337365-hugenn14	123	41	-	-	HYPH
cord-337365-hugenn14	123	42	α	α	NNP
cord-337365-hugenn14	123	43	[	[	-LRB-
cord-337365-hugenn14	123	44	30	30	CD
cord-337365-hugenn14	123	45	]	]	-RRB-
cord-337365-hugenn14	123	46	.	.	.
cord-337365-hugenn14	124	1	It	-PRON-	PRP
cord-337365-hugenn14	124	2	is	be	VBZ
cord-337365-hugenn14	124	3	well	well	RB
cord-337365-hugenn14	124	4	known	know	VBN
cord-337365-hugenn14	124	5	that	that	IN
cord-337365-hugenn14	124	6	vascular	vascular	JJ
cord-337365-hugenn14	124	7	cell	cell	NN
cord-337365-hugenn14	124	8	adhesion	adhesion	NN
cord-337365-hugenn14	124	9	molecule	molecule	NN
cord-337365-hugenn14	124	10	1	1	CD
cord-337365-hugenn14	124	11	(	(	-LRB-
cord-337365-hugenn14	124	12	VCAM-1	VCAM-1	NNP
cord-337365-hugenn14	124	13	)	)	-RRB-
cord-337365-hugenn14	124	14	is	be	VBZ
cord-337365-hugenn14	124	15	a	a	DT
cord-337365-hugenn14	124	16	neuroinflammatory	neuroinflammatory	JJ
cord-337365-hugenn14	124	17	regulator	regulator	NN
cord-337365-hugenn14	124	18	on	on	IN
cord-337365-hugenn14	124	19	vascular	vascular	JJ
cord-337365-hugenn14	124	20	endothelial	endothelial	JJ
cord-337365-hugenn14	124	21	cells	cell	NNS
cord-337365-hugenn14	124	22	[	[	-LRB-
cord-337365-hugenn14	124	23	31	31	CD
cord-337365-hugenn14	124	24	]	]	-RRB-
cord-337365-hugenn14	124	25	.	.	.
cord-337365-hugenn14	125	1	IFN-1	IFN-1	NNP
cord-337365-hugenn14	125	2	regulates	regulate	VBZ
cord-337365-hugenn14	125	3	immune	immune	JJ
cord-337365-hugenn14	125	4	transport	transport	NN
cord-337365-hugenn14	125	5	by	by	IN
cord-337365-hugenn14	125	6	regulating	regulate	VBG
cord-337365-hugenn14	125	7	the	the	DT
cord-337365-hugenn14	125	8	expression	expression	NN
cord-337365-hugenn14	125	9	of	of	IN
cord-337365-hugenn14	125	10	VCAM-1	VCAM-1	NNP
cord-337365-hugenn14	125	11	(	(	-LRB-
cord-337365-hugenn14	125	12	CD	CD	NNP
cord-337365-hugenn14	125	13	106	106	CD
cord-337365-hugenn14	125	14	)	)	-RRB-
cord-337365-hugenn14	125	15	on	on	IN
cord-337365-hugenn14	125	16	neurovasculature	neurovasculature	NNP
cord-337365-hugenn14	125	17	[	[	-LRB-
cord-337365-hugenn14	125	18	32	32	CD
cord-337365-hugenn14	125	19	]	]	-RRB-
cord-337365-hugenn14	125	20	.	.	.
cord-337365-hugenn14	126	1	IFN	IFN	NNP
cord-337365-hugenn14	126	2	-	-	HYPH
cord-337365-hugenn14	126	3	β	β	NNP
cord-337365-hugenn14	126	4	treatment	treatment	NN
cord-337365-hugenn14	126	5	of	of	IN
cord-337365-hugenn14	126	6	either	either	DT
cord-337365-hugenn14	126	7	human	human	JJ
cord-337365-hugenn14	126	8	or	or	CC
cord-337365-hugenn14	126	9	mouse	mouse	NN
cord-337365-hugenn14	126	10	primary	primary	JJ
cord-337365-hugenn14	126	11	astrocyte	astrocyte	NNP
cord-337365-hugenn14	126	12	cultures	culture	NNS
cord-337365-hugenn14	126	13	from	from	IN
cord-337365-hugenn14	126	14	the	the	DT
cord-337365-hugenn14	126	15	cerebellum	cerebellum	NN
cord-337365-hugenn14	126	16	,	,	,
cord-337365-hugenn14	126	17	but	but	CC
cord-337365-hugenn14	126	18	not	not	RB
cord-337365-hugenn14	126	19	from	from	IN
cord-337365-hugenn14	126	20	the	the	DT
cord-337365-hugenn14	126	21	cerebral	cerebral	JJ
cord-337365-hugenn14	126	22	cortex	cortex	NN
cord-337365-hugenn14	126	23	,	,	,
cord-337365-hugenn14	126	24	significantly	significantly	RB
cord-337365-hugenn14	126	25	downregulates	downregulate	VBZ
cord-337365-hugenn14	126	26	VCAM-1	VCAM-1	NNP
cord-337365-hugenn14	126	27	expression	expression	NN
cord-337365-hugenn14	126	28	[	[	-LRB-
cord-337365-hugenn14	126	29	29	29	CD
cord-337365-hugenn14	126	30	]	]	-RRB-
cord-337365-hugenn14	126	31	.	.	.
cord-337365-hugenn14	127	1	Drug	drug	NN
cord-337365-hugenn14	127	2	blocking	blocking	NN
cord-337365-hugenn14	127	3	of	of	IN
cord-337365-hugenn14	127	4	VCAM-1	VCAM-1	NNP
cord-337365-hugenn14	127	5	binding	bind	VBG
cord-337365-hugenn14	127	6	to	to	IN
cord-337365-hugenn14	127	7	its	-PRON-	PRP$
cord-337365-hugenn14	127	8	ligand	ligand	NN
cord-337365-hugenn14	127	9	leukocyte	leukocyte	NN
cord-337365-hugenn14	127	10	adhesion	adhesion	NN
cord-337365-hugenn14	127	11	molecule	molecule	NN
cord-337365-hugenn14	127	12	4	4	CD
cord-337365-hugenn14	127	13	(	(	-LRB-
cord-337365-hugenn14	127	14	VLA-4	VLA-4	NNP
cord-337365-hugenn14	127	15	)	)	-RRB-
cord-337365-hugenn14	127	16	has	have	VBZ
cord-337365-hugenn14	127	17	been	be	VBN
cord-337365-hugenn14	127	18	shown	show	VBN
cord-337365-hugenn14	127	19	to	to	TO
cord-337365-hugenn14	127	20	reduce	reduce	VB
cord-337365-hugenn14	127	21	pathogenic	pathogenic	JJ
cord-337365-hugenn14	127	22	neuroinflammation	neuroinflammation	NN
cord-337365-hugenn14	127	23	and	and	CC
cord-337365-hugenn14	127	24	improve	improve	VB
cord-337365-hugenn14	127	25	survival	survival	NN
cord-337365-hugenn14	127	26	after	after	IN
cord-337365-hugenn14	127	27	WNV	WNV	NNP
cord-337365-hugenn14	127	28	infection	infection	NN
cord-337365-hugenn14	127	29	[	[	-LRB-
cord-337365-hugenn14	127	30	33	33	CD
cord-337365-hugenn14	127	31	]	]	-RRB-
cord-337365-hugenn14	127	32	.	.	.
cord-337365-hugenn14	128	1	In	in	IN
cord-337365-hugenn14	128	2	IFNAR	IFNAR	NNP
cord-337365-hugenn14	128	3	-	-	HYPH
cord-337365-hugenn14	128	4	deficient	deficient	JJ
cord-337365-hugenn14	128	5	mice	mouse	NNS
cord-337365-hugenn14	128	6	,	,	,
cord-337365-hugenn14	128	7	cerebellar	cerebellar	JJ
cord-337365-hugenn14	128	8	Vasek	Vasek	NNPS
cord-337365-hugenn14	128	9	et	et	FW
cord-337365-hugenn14	128	10	al	al	NNP
cord-337365-hugenn14	128	11	.	.	.
cord-337365-hugenn14	129	1	[	[	-LRB-
cord-337365-hugenn14	129	2	52	52	CD
cord-337365-hugenn14	129	3	]	]	-RRB-
cord-337365-hugenn14	130	1	Complement	complement	JJ
cord-337365-hugenn14	130	2	C3	C3	NNP
cord-337365-hugenn14	130	3	and	and	CC
cord-337365-hugenn14	130	4	C3	c3	NN
cord-337365-hugenn14	130	5	cleavage	cleavage	NN
cord-337365-hugenn14	130	6	products	product	NNS
cord-337365-hugenn14	130	7	C3R	C3R	NNP
cord-337365-hugenn14	130	8	Cell	Cell	NNP
cord-337365-hugenn14	130	9	surface	surface	NN
cord-337365-hugenn14	130	10	Damaging	damaging	NN
cord-337365-hugenn14	130	11	of	of	IN
cord-337365-hugenn14	130	12	presynaptic	presynaptic	JJ
cord-337365-hugenn14	130	13	ends	end	NNS
cord-337365-hugenn14	130	14	and	and	CC
cord-337365-hugenn14	130	15	resulting	result	VBG
cord-337365-hugenn14	130	16	in	in	IN
cord-337365-hugenn14	130	17	visual	visual	JJ
cord-337365-hugenn14	130	18	-	-	HYPH
cord-337365-hugenn14	130	19	spatial	spatial	JJ
cord-337365-hugenn14	130	20	processing	processing	NN
cord-337365-hugenn14	130	21	disorders	disorder	NNS
cord-337365-hugenn14	130	22	and	and	CC
cord-337365-hugenn14	130	23	impaired	impaired	JJ
cord-337365-hugenn14	130	24	memory	memory	NN
cord-337365-hugenn14	130	25	function	function	NN
cord-337365-hugenn14	130	26	infiltrating	infiltrate	VBG
cord-337365-hugenn14	130	27	lymphocytes	lymphocyte	NNS
cord-337365-hugenn14	130	28	and	and	CC
cord-337365-hugenn14	130	29	macrophages	macrophage	NNS
cord-337365-hugenn14	130	30	were	be	VBD
cord-337365-hugenn14	130	31	significantly	significantly	RB
cord-337365-hugenn14	130	32	reduced	reduce	VBN
cord-337365-hugenn14	130	33	after	after	IN
cord-337365-hugenn14	130	34	treatment	treatment	NN
cord-337365-hugenn14	130	35	with	with	IN
cord-337365-hugenn14	130	36	VLA-4	VLA-4	NNP
cord-337365-hugenn14	130	37	blocker	blocker	NN
cord-337365-hugenn14	130	38	[	[	-LRB-
cord-337365-hugenn14	130	39	29	29	CD
cord-337365-hugenn14	130	40	]	]	-RRB-
cord-337365-hugenn14	130	41	.	.	.
cord-337365-hugenn14	131	1	Loss	loss	NN
cord-337365-hugenn14	131	2	of	of	IN
cord-337365-hugenn14	131	3	astrocyte	astrocyte	NNP
cord-337365-hugenn14	131	4	IFNAR	IFNAR	NNP
cord-337365-hugenn14	131	5	signaling	signal	VBG
cord-337365-hugenn14	131	6	pathway	pathway	NN
cord-337365-hugenn14	131	7	can	can	MD
cord-337365-hugenn14	131	8	cause	cause	VB
cord-337365-hugenn14	131	9	a	a	DT
cord-337365-hugenn14	131	10	variety	variety	NN
cord-337365-hugenn14	131	11	of	of	IN
cord-337365-hugenn14	131	12	consequences	consequence	NNS
cord-337365-hugenn14	131	13	,	,	,
cord-337365-hugenn14	131	14	including	include	VBG
cord-337365-hugenn14	131	15	increased	increase	VBN
cord-337365-hugenn14	131	16	expression	expression	NN
cord-337365-hugenn14	131	17	of	of	IN
cord-337365-hugenn14	131	18	inflammatory	inflammatory	JJ
cord-337365-hugenn14	131	19	cytokines	cytokine	NNS
cord-337365-hugenn14	131	20	and	and	CC
cord-337365-hugenn14	131	21	chemokines	chemokine	NNS
cord-337365-hugenn14	131	22	,	,	,
cord-337365-hugenn14	131	23	which	which	WDT
cord-337365-hugenn14	131	24	disrupt	disrupt	VBP
cord-337365-hugenn14	131	25	the	the	DT
cord-337365-hugenn14	131	26	blood	blood	NN
cord-337365-hugenn14	131	27	-	-	HYPH
cord-337365-hugenn14	131	28	brain	brain	NN
cord-337365-hugenn14	131	29	barrier	barrier	NN
cord-337365-hugenn14	131	30	during	during	IN
cord-337365-hugenn14	131	31	neurotropic	neurotropic	NNP
cord-337365-hugenn14	131	32	viral	viral	JJ
cord-337365-hugenn14	131	33	infection	infection	NN
cord-337365-hugenn14	131	34	[	[	-LRB-
cord-337365-hugenn14	131	35	30	30	CD
cord-337365-hugenn14	131	36	]	]	-RRB-
cord-337365-hugenn14	131	37	.	.	.
cord-337365-hugenn14	132	1	In	in	IN
cord-337365-hugenn14	132	2	different	different	JJ
cord-337365-hugenn14	132	3	brain	brain	NN
cord-337365-hugenn14	132	4	regions	region	NNS
cord-337365-hugenn14	132	5	,	,	,
cord-337365-hugenn14	132	6	transcription	transcription	NN
cord-337365-hugenn14	132	7	,	,	,
cord-337365-hugenn14	132	8	immunophenotypic	immunophenotypic	NNP
cord-337365-hugenn14	132	9	,	,	,
cord-337365-hugenn14	132	10	and	and	CC
cord-337365-hugenn14	132	11	bioenergetic	bioenergetic	JJ
cord-337365-hugenn14	132	12	properties	property	NNS
cord-337365-hugenn14	132	13	of	of	IN
cord-337365-hugenn14	132	14	microglia	microglia	NNS
cord-337365-hugenn14	132	15	are	be	VBP
cord-337365-hugenn14	132	16	heterogeneous	heterogeneous	JJ
cord-337365-hugenn14	132	17	.	.	.
cord-337365-hugenn14	133	1	Cerebellar	cerebellar	JJ
cord-337365-hugenn14	133	2	and	and	CC
cord-337365-hugenn14	133	3	hippocampal	hippocampal	JJ
cord-337365-hugenn14	133	4	microglia	microglia	NNS
cord-337365-hugenn14	133	5	maintain	maintain	VBP
cord-337365-hugenn14	133	6	a	a	DT
cord-337365-hugenn14	133	7	stronger	strong	JJR
cord-337365-hugenn14	133	8	immune	immune	JJ
cord-337365-hugenn14	133	9	alert	alert	JJ
cord-337365-hugenn14	133	10	status	status	NN
cord-337365-hugenn14	133	11	than	than	IN
cord-337365-hugenn14	133	12	microglia	microglia	NNS
cord-337365-hugenn14	133	13	in	in	IN
cord-337365-hugenn14	133	14	the	the	DT
cord-337365-hugenn14	133	15	striatum	striatum	NN
cord-337365-hugenn14	133	16	and	and	CC
cord-337365-hugenn14	133	17	cortex	cortex	NN
cord-337365-hugenn14	133	18	.	.	.
cord-337365-hugenn14	134	1	The	the	DT
cord-337365-hugenn14	134	2	sensitivity	sensitivity	NN
cord-337365-hugenn14	134	3	of	of	IN
cord-337365-hugenn14	134	4	different	different	JJ
cord-337365-hugenn14	134	5	brain	brain	NN
cord-337365-hugenn14	134	6	regions	region	NNS
cord-337365-hugenn14	134	7	to	to	IN
cord-337365-hugenn14	134	8	aging	age	VBG
cord-337365-hugenn14	134	9	is	be	VBZ
cord-337365-hugenn14	134	10	different	different	JJ
cord-337365-hugenn14	134	11	,	,	,
cord-337365-hugenn14	134	12	and	and	CC
cord-337365-hugenn14	134	13	the	the	DT
cord-337365-hugenn14	134	14	cerebellum	cerebellum	NN
cord-337365-hugenn14	134	15	is	be	VBZ
cord-337365-hugenn14	134	16	the	the	DT
cord-337365-hugenn14	134	17	most	most	RBS
cord-337365-hugenn14	134	18	obvious	obvious	JJ
cord-337365-hugenn14	134	19	.	.	.
cord-337365-hugenn14	135	1	This	this	DT
cord-337365-hugenn14	135	2	suggests	suggest	VBZ
cord-337365-hugenn14	135	3	that	that	IN
cord-337365-hugenn14	135	4	different	different	JJ
cord-337365-hugenn14	135	5	brain	brain	NN
cord-337365-hugenn14	135	6	regions	region	NNS
cord-337365-hugenn14	135	7	have	have	VBP
cord-337365-hugenn14	135	8	different	different	JJ
cord-337365-hugenn14	135	9	responses	response	NNS
cord-337365-hugenn14	135	10	to	to	IN
cord-337365-hugenn14	135	11	aging	age	VBG
cord-337365-hugenn14	135	12	-	-	HYPH
cord-337365-hugenn14	135	13	related	relate	VBN
cord-337365-hugenn14	135	14	neurodegenerative	neurodegenerative	JJ
cord-337365-hugenn14	135	15	lesions	lesion	NNS
cord-337365-hugenn14	135	16	[	[	-LRB-
cord-337365-hugenn14	135	17	34	34	CD
cord-337365-hugenn14	135	18	]	]	-RRB-
cord-337365-hugenn14	135	19	.	.	.
cord-337365-hugenn14	136	1	Microglia	Microglia	NNP
cord-337365-hugenn14	136	2	also	also	RB
cord-337365-hugenn14	136	3	affect	affect	VBP
cord-337365-hugenn14	136	4	the	the	DT
cord-337365-hugenn14	136	5	adaptive	adaptive	JJ
cord-337365-hugenn14	136	6	immune	immune	JJ
cord-337365-hugenn14	136	7	response	response	NN
cord-337365-hugenn14	136	8	.	.	.
cord-337365-hugenn14	137	1	Depletion	depletion	NN
cord-337365-hugenn14	137	2	of	of	IN
cord-337365-hugenn14	137	3	microglia	microglia	NN
cord-337365-hugenn14	137	4	changes	change	VBZ
cord-337365-hugenn14	137	5	the	the	DT
cord-337365-hugenn14	137	6	response	response	NN
cord-337365-hugenn14	137	7	of	of	IN
cord-337365-hugenn14	137	8	CD4	CD4	NNP
cord-337365-hugenn14	137	9	+	+	CC
cord-337365-hugenn14	137	10	T	T	NNP
cord-337365-hugenn14	137	11	cells	cell	NNS
cord-337365-hugenn14	137	12	to	to	IN
cord-337365-hugenn14	137	13	viral	viral	JJ
cord-337365-hugenn14	137	14	infection	infection	NN
cord-337365-hugenn14	137	15	in	in	IN
cord-337365-hugenn14	137	16	the	the	DT
cord-337365-hugenn14	137	17	brain	brain	NN
cord-337365-hugenn14	137	18	,	,	,
cord-337365-hugenn14	137	19	the	the	DT
cord-337365-hugenn14	137	20	total	total	JJ
cord-337365-hugenn14	137	21	number	number	NN
cord-337365-hugenn14	137	22	and	and	CC
cord-337365-hugenn14	137	23	percentage	percentage	NN
cord-337365-hugenn14	137	24	of	of	IN
cord-337365-hugenn14	137	25	CD4	CD4	NNP
cord-337365-hugenn14	137	26	+	+	CC
cord-337365-hugenn14	137	27	T	T	NNP
cord-337365-hugenn14	137	28	cells	cell	NNS
cord-337365-hugenn14	137	29	decrease	decrease	VBP
cord-337365-hugenn14	137	30	,	,	,
cord-337365-hugenn14	137	31	and	and	CC
cord-337365-hugenn14	137	32	the	the	DT
cord-337365-hugenn14	137	33	frequency	frequency	NN
cord-337365-hugenn14	137	34	and	and	CC
cord-337365-hugenn14	137	35	number	number	NN
cord-337365-hugenn14	137	36	of	of	IN
cord-337365-hugenn14	137	37	Tregs	Tregs	NNP
cord-337365-hugenn14	138	1	also	also	RB
cord-337365-hugenn14	138	2	decrease	decrease	VB
cord-337365-hugenn14	138	3	,	,	,
cord-337365-hugenn14	138	4	indicating	indicate	VBG
cord-337365-hugenn14	138	5	that	that	IN
cord-337365-hugenn14	138	6	microglia	microglia	NNS
cord-337365-hugenn14	138	7	are	be	VBP
cord-337365-hugenn14	138	8	crucial	crucial	JJ
cord-337365-hugenn14	138	9	for	for	IN
cord-337365-hugenn14	138	10	fully	fully	RB
cord-337365-hugenn14	138	11	activating	activate	VBG
cord-337365-hugenn14	138	12	virus	virus	NN
cord-337365-hugenn14	138	13	-	-	HYPH
cord-337365-hugenn14	138	14	specific	specific	JJ
cord-337365-hugenn14	138	15	T	t	NN
cord-337365-hugenn14	138	16	cells	cell	NNS
cord-337365-hugenn14	138	17	.	.	.
cord-337365-hugenn14	139	1	Deletion	deletion	NN
cord-337365-hugenn14	139	2	of	of	IN
cord-337365-hugenn14	139	3	microglia	microglia	NNS
cord-337365-hugenn14	139	4	in	in	IN
cord-337365-hugenn14	139	5	the	the	DT
cord-337365-hugenn14	139	6	early	early	JJ
cord-337365-hugenn14	139	7	stages	stage	NNS
cord-337365-hugenn14	139	8	of	of	IN
cord-337365-hugenn14	139	9	WHV	WHV	NNP
cord-337365-hugenn14	139	10	infection	infection	NN
cord-337365-hugenn14	139	11	exacerbates	exacerbate	VBZ
cord-337365-hugenn14	139	12	infection	infection	NN
cord-337365-hugenn14	139	13	,	,	,
cord-337365-hugenn14	139	14	which	which	WDT
cord-337365-hugenn14	139	15	may	may	MD
cord-337365-hugenn14	139	16	be	be	VB
cord-337365-hugenn14	139	17	associated	associate	VBN
cord-337365-hugenn14	139	18	with	with	IN
cord-337365-hugenn14	139	19	loss	loss	NN
cord-337365-hugenn14	139	20	of	of	IN
cord-337365-hugenn14	139	21	microglial	microglial	JJ
cord-337365-hugenn14	139	22	antigen	antigen	NN
cord-337365-hugenn14	139	23	presentation	presentation	NN
cord-337365-hugenn14	139	24	function	function	NN
cord-337365-hugenn14	139	25	,	,	,
cord-337365-hugenn14	139	26	as	as	IN
cord-337365-hugenn14	139	27	microglia	microglia	NNP
cord-337365-hugenn14	139	28	participates	participate	VBZ
cord-337365-hugenn14	139	29	in	in	IN
cord-337365-hugenn14	139	30	antigen	antigen	NN
cord-337365-hugenn14	139	31	presentation	presentation	NN
cord-337365-hugenn14	139	32	by	by	IN
cord-337365-hugenn14	139	33	upregulating	upregulate	VBG
cord-337365-hugenn14	139	34	Tap1	Tap1	NNP
cord-337365-hugenn14	139	35	and	and	CC
cord-337365-hugenn14	139	36	Itgax	Itgax	NNP
cord-337365-hugenn14	139	37	.	.	.
cord-337365-hugenn14	140	1	Depletion	depletion	NN
cord-337365-hugenn14	140	2	of	of	IN
cord-337365-hugenn14	140	3	microglia	microglia	NN
cord-337365-hugenn14	140	4	can	can	MD
cord-337365-hugenn14	140	5	also	also	RB
cord-337365-hugenn14	140	6	result	result	VB
cord-337365-hugenn14	140	7	in	in	IN
cord-337365-hugenn14	140	8	the	the	DT
cord-337365-hugenn14	140	9	loss	loss	NN
cord-337365-hugenn14	140	10	of	of	IN
cord-337365-hugenn14	140	11	major	major	JJ
cord-337365-hugenn14	140	12	MHC	MHC	NNP
cord-337365-hugenn14	140	13	II	II	NNP
cord-337365-hugenn14	140	14	-	-	HYPH
cord-337365-hugenn14	140	15	expressing	express	VBG
cord-337365-hugenn14	140	16	cell	cell	NN
cord-337365-hugenn14	140	17	type	type	NN
cord-337365-hugenn14	140	18	,	,	,
cord-337365-hugenn14	140	19	which	which	WDT
cord-337365-hugenn14	140	20	can	can	MD
cord-337365-hugenn14	140	21	also	also	RB
cord-337365-hugenn14	140	22	result	result	VB
cord-337365-hugenn14	140	23	in	in	IN
cord-337365-hugenn14	140	24	decreased	decreased	JJ
cord-337365-hugenn14	140	25	expression	expression	NN
cord-337365-hugenn14	140	26	of	of	IN
cord-337365-hugenn14	140	27	MHC	MHC	NNP
cord-337365-hugenn14	140	28	II	II	NNP
cord-337365-hugenn14	140	29	in	in	IN
cord-337365-hugenn14	140	30	incoming	incoming	JJ
cord-337365-hugenn14	140	31	monocytes	monocyte	NNS
cord-337365-hugenn14	140	32	/	/	SYM
cord-337365-hugenn14	140	33	macrophages	macrophage	NNS
cord-337365-hugenn14	140	34	.	.	.
cord-337365-hugenn14	141	1	Because	because	IN
cord-337365-hugenn14	141	2	MHC	MHC	NNP
cord-337365-hugenn14	141	3	II	II	NNP
cord-337365-hugenn14	141	4	is	be	VBZ
cord-337365-hugenn14	141	5	required	require	VBN
cord-337365-hugenn14	141	6	for	for	IN
cord-337365-hugenn14	141	7	re	re	NN
cord-337365-hugenn14	141	8	-	-	NN
cord-337365-hugenn14	141	9	stimulation	stimulation	NN
cord-337365-hugenn14	141	10	and	and	CC
cord-337365-hugenn14	141	11	activation	activation	NN
cord-337365-hugenn14	141	12	of	of	IN
cord-337365-hugenn14	141	13	CD4	CD4	NNP
cord-337365-hugenn14	141	14	+	+	CC
cord-337365-hugenn14	141	15	T	T	NNP
cord-337365-hugenn14	141	16	cells	cell	NNS
cord-337365-hugenn14	141	17	,	,	,
cord-337365-hugenn14	141	18	a	a	DT
cord-337365-hugenn14	141	19	decrease	decrease	NN
cord-337365-hugenn14	141	20	in	in	IN
cord-337365-hugenn14	141	21	MHC	MHC	NNP
cord-337365-hugenn14	141	22	II	II	NNP
cord-337365-hugenn14	141	23	reduces	reduce	VBZ
cord-337365-hugenn14	141	24	the	the	DT
cord-337365-hugenn14	141	25	response	response	NN
cord-337365-hugenn14	141	26	of	of	IN
cord-337365-hugenn14	141	27	virus	virus	NN
cord-337365-hugenn14	141	28	-	-	HYPH
cord-337365-hugenn14	141	29	specific	specific	JJ
cord-337365-hugenn14	141	30	CD4	CD4	NNP
cord-337365-hugenn14	141	31	+	+	CC
cord-337365-hugenn14	141	32	T	t	NN
cord-337365-hugenn14	141	33	cells	cell	NNS
cord-337365-hugenn14	141	34	[	[	-LRB-
cord-337365-hugenn14	141	35	14	14	CD
cord-337365-hugenn14	141	36	]	]	-RRB-
cord-337365-hugenn14	141	37	.	.	.
cord-337365-hugenn14	142	1	In	in	IN
cord-337365-hugenn14	142	2	addition	addition	NN
cord-337365-hugenn14	142	3	to	to	IN
cord-337365-hugenn14	142	4	producing	produce	VBG
cord-337365-hugenn14	142	5	IFN-1	IFN-1	NNP
cord-337365-hugenn14	142	6	,	,	,
cord-337365-hugenn14	142	7	microglia	microglia	NNS
cord-337365-hugenn14	142	8	can	can	MD
cord-337365-hugenn14	142	9	also	also	RB
cord-337365-hugenn14	142	10	produce	produce	VB
cord-337365-hugenn14	142	11	other	other	JJ
cord-337365-hugenn14	142	12	cytokines	cytokine	NNS
cord-337365-hugenn14	142	13	.	.	.
cord-337365-hugenn14	143	1	The	the	DT
cord-337365-hugenn14	143	2	vitro	vitro	FW
cord-337365-hugenn14	143	3	cell	cell	NN
cord-337365-hugenn14	143	4	culture	culture	NN
cord-337365-hugenn14	143	5	demonstrates	demonstrate	VBZ
cord-337365-hugenn14	143	6	that	that	IN
cord-337365-hugenn14	143	7	cytomegalovirus	cytomegalovirus	NNP
cord-337365-hugenn14	143	8	(	(	-LRB-
cord-337365-hugenn14	143	9	CMV)-infected	cmv)-infecte	VBN
cord-337365-hugenn14	143	10	astrocytes	astrocyte	NNS
cord-337365-hugenn14	143	11	recruit	recruit	VBP
cord-337365-hugenn14	143	12	microglia	microglia	NNS
cord-337365-hugenn14	143	13	to	to	IN
cord-337365-hugenn14	143	14	the	the	DT
cord-337365-hugenn14	143	15	infected	infected	JJ
cord-337365-hugenn14	143	16	foci	foci	NN
cord-337365-hugenn14	143	17	by	by	IN
cord-337365-hugenn14	143	18	releasing	release	VBG
cord-337365-hugenn14	143	19	monocyte	monocyte	NNP
cord-337365-hugenn14	143	20	chemoattractant	chemoattractant	NNP
cord-337365-hugenn14	143	21	protein	protein	NN
cord-337365-hugenn14	143	22	1	1	CD
cord-337365-hugenn14	143	23	(	(	-LRB-
cord-337365-hugenn14	143	24	MCP-1	MCP-1	NNP
cord-337365-hugenn14	143	25	)	)	-RRB-
cord-337365-hugenn14	143	26	.	.	.
cord-337365-hugenn14	144	1	Microglia	Microglia	NNP
cord-337365-hugenn14	144	2	produces	produce	VBZ
cord-337365-hugenn14	144	3	tumor	tumor	NN
cord-337365-hugenn14	144	4	necrosis	necrosis	NN
cord-337365-hugenn14	144	5	factor	factor	NN
cord-337365-hugenn14	144	6	α	α	NNP
cord-337365-hugenn14	144	7	(	(	-LRB-
cord-337365-hugenn14	144	8	TNFα	TNFα	NNP
cord-337365-hugenn14	144	9	)	)	-RRB-
cord-337365-hugenn14	144	10	and	and	CC
cord-337365-hugenn14	144	11	interleukin	interleukin	NN
cord-337365-hugenn14	144	12	1β	1β	NNS
cord-337365-hugenn14	144	13	(	(	-LRB-
cord-337365-hugenn14	144	14	IL-1β	IL-1β	NNP
cord-337365-hugenn14	144	15	)	)	-RRB-
cord-337365-hugenn14	144	16	,	,	,
cord-337365-hugenn14	144	17	interleukin	interleukin	NN
cord-337365-hugenn14	144	18	6	6	CD
cord-337365-hugenn14	144	19	(	(	-LRB-
cord-337365-hugenn14	144	20	IL-6	IL-6	NNP
cord-337365-hugenn14	144	21	)	)	-RRB-
cord-337365-hugenn14	144	22	exerting	exert	VBG
cord-337365-hugenn14	144	23	antiviral	antiviral	JJ
cord-337365-hugenn14	144	24	effect	effect	NN
cord-337365-hugenn14	144	25	and	and	CC
cord-337365-hugenn14	144	26	inhibiting	inhibit	VBG
cord-337365-hugenn14	144	27	the	the	DT
cord-337365-hugenn14	144	28	replication	replication	NN
cord-337365-hugenn14	144	29	of	of	IN
cord-337365-hugenn14	144	30	CMV	CMV	NNP
cord-337365-hugenn14	144	31	in	in	IN
cord-337365-hugenn14	144	32	astrocytes	astrocyte	NNS
cord-337365-hugenn14	144	33	[	[	-LRB-
cord-337365-hugenn14	144	34	35	35	CD
cord-337365-hugenn14	144	35	]	]	-RRB-
cord-337365-hugenn14	144	36	.	.	.
cord-337365-hugenn14	145	1	CMV	CMV	NNP
cord-337365-hugenn14	145	2	-	-	HYPH
cord-337365-hugenn14	145	3	infected	infect	VBN
cord-337365-hugenn14	145	4	microglia	microglia	NNS
cord-337365-hugenn14	145	5	produce	produce	VBP
cord-337365-hugenn14	145	6	T	T	NNP
cord-337365-hugenn14	145	7	lymphocyte	lymphocyte	NN
cord-337365-hugenn14	145	8	chemotactic	chemotactic	JJ
cord-337365-hugenn14	145	9	factor	factor	NN
cord-337365-hugenn14	145	10	CXCL	CXCL	NNP
cord-337365-hugenn14	145	11	10	10	CD
cord-337365-hugenn14	145	12	,	,	,
cord-337365-hugenn14	145	13	recruiting	recruit	VBG
cord-337365-hugenn14	145	14	activated	activate	VBN
cord-337365-hugenn14	145	15	T	t	NN
cord-337365-hugenn14	145	16	lymphocytes	lymphocyte	NNS
cord-337365-hugenn14	145	17	into	into	IN
cord-337365-hugenn14	145	18	the	the	DT
cord-337365-hugenn14	145	19	infected	infected	JJ
cord-337365-hugenn14	145	20	area	area	NN
cord-337365-hugenn14	145	21	,	,	,
cord-337365-hugenn14	145	22	and	and	CC
cord-337365-hugenn14	145	23	T	t	NN
cord-337365-hugenn14	145	24	cells	cell	NNS
cord-337365-hugenn14	145	25	produce	produce	VBP
cord-337365-hugenn14	145	26	IFN	IFN	NNP
cord-337365-hugenn14	145	27	-	-	HYPH
cord-337365-hugenn14	145	28	γ	γ	NN
cord-337365-hugenn14	145	29	to	to	TO
cord-337365-hugenn14	145	30	inhibit	inhibit	VB
cord-337365-hugenn14	145	31	virus	virus	NN
cord-337365-hugenn14	145	32	replication	replication	NN
cord-337365-hugenn14	145	33	and	and	CC
cord-337365-hugenn14	145	34	dissemination	dissemination	NN
cord-337365-hugenn14	145	35	[	[	-LRB-
cord-337365-hugenn14	145	36	36	36	CD
cord-337365-hugenn14	145	37	]	]	-RRB-
cord-337365-hugenn14	145	38	.	.	.
cord-337365-hugenn14	146	1	Even	even	RB
cord-337365-hugenn14	146	2	with	with	IN
cord-337365-hugenn14	146	3	limited	limited	JJ
cord-337365-hugenn14	146	4	viral	viral	JJ
cord-337365-hugenn14	146	5	replication	replication	NN
cord-337365-hugenn14	146	6	,	,	,
cord-337365-hugenn14	146	7	cytopathic	cytopathic	JJ
cord-337365-hugenn14	146	8	effects	effect	NNS
cord-337365-hugenn14	146	9	were	be	VBD
cord-337365-hugenn14	146	10	evident	evident	JJ
cord-337365-hugenn14	146	11	in	in	IN
cord-337365-hugenn14	146	12	the	the	DT
cord-337365-hugenn14	146	13	HSV	HSV	NNP
cord-337365-hugenn14	146	14	-	-	HYPH
cord-337365-hugenn14	146	15	infected	infect	VBN
cord-337365-hugenn14	146	16	microglia	microglia	NNS
cord-337365-hugenn14	146	17	.	.	.
cord-337365-hugenn14	147	1	Microglia	Microglia	NNP
cord-337365-hugenn14	147	2	responded	respond	VBD
cord-337365-hugenn14	147	3	to	to	IN
cord-337365-hugenn14	147	4	nonpermissive	nonpermissive	JJ
cord-337365-hugenn14	147	5	viral	viral	JJ
cord-337365-hugenn14	147	6	infection	infection	NN
cord-337365-hugenn14	147	7	by	by	IN
cord-337365-hugenn14	147	8	producing	produce	VBG
cord-337365-hugenn14	147	9	considerable	considerable	JJ
cord-337365-hugenn14	147	10	amounts	amount	NNS
cord-337365-hugenn14	147	11	of	of	IN
cord-337365-hugenn14	147	12	TNF	TNF	NNP
cord-337365-hugenn14	147	13	-	-	HYPH
cord-337365-hugenn14	147	14	α	α	NNP
cord-337365-hugenn14	147	15	,	,	,
cord-337365-hugenn14	147	16	IL-1β	IL-1β	NNP
cord-337365-hugenn14	147	17	,	,	,
cord-337365-hugenn14	147	18	and	and	CC
cord-337365-hugenn14	147	19	IP-10	IP-10	NNP
cord-337365-hugenn14	147	20	.	.	.
cord-337365-hugenn14	148	1	TNF	TNF	NNP
cord-337365-hugenn14	148	2	-	-	HYPH
cord-337365-hugenn14	148	3	α	α	NNP
cord-337365-hugenn14	148	4	inhibits	inhibit	VBZ
cord-337365-hugenn14	148	5	HSV	HSV	NNP
cord-337365-hugenn14	148	6	replication	replication	NN
cord-337365-hugenn14	148	7	in	in	IN
cord-337365-hugenn14	148	8	astrocytes	astrocyte	NNS
cord-337365-hugenn14	148	9	,	,	,
cord-337365-hugenn14	148	10	and	and	CC
cord-337365-hugenn14	148	11	IP-10	IP-10	NNP
cord-337365-hugenn14	148	12	possesses	possess	VBZ
cord-337365-hugenn14	148	13	direct	direct	JJ
cord-337365-hugenn14	148	14	antiviral	antiviral	JJ
cord-337365-hugenn14	148	15	activity	activity	NN
cord-337365-hugenn14	148	16	in	in	IN
cord-337365-hugenn14	148	17	neurons	neuron	NNS
cord-337365-hugenn14	148	18	[	[	-LRB-
cord-337365-hugenn14	148	19	37	37	CD
cord-337365-hugenn14	148	20	]	]	-RRB-
cord-337365-hugenn14	148	21	.	.	.
cord-337365-hugenn14	149	1	Inflammation	inflammation	NN
cord-337365-hugenn14	149	2	-	-	HYPH
cord-337365-hugenn14	149	3	induced	induce	VBN
cord-337365-hugenn14	149	4	,	,	,
cord-337365-hugenn14	149	5	STING	sting	NN
cord-337365-hugenn14	149	6	-	-	HYPH
cord-337365-hugenn14	149	7	dependent	dependent	JJ
cord-337365-hugenn14	149	8	autophagy	autophagy	NN
cord-337365-hugenn14	149	9	limits	limit	VBZ
cord-337365-hugenn14	149	10	Zika	Zika	NNP
cord-337365-hugenn14	149	11	virus	virus	NN
cord-337365-hugenn14	149	12	(	(	-LRB-
cord-337365-hugenn14	149	13	ZIKV	zikv	NN
cord-337365-hugenn14	149	14	)	)	-RRB-
cord-337365-hugenn14	149	15	infection	infection	NN
cord-337365-hugenn14	149	16	in	in	IN
cord-337365-hugenn14	149	17	Drosophila	drosophila	JJ
cord-337365-hugenn14	149	18	brains	brain	NNS
cord-337365-hugenn14	149	19	.	.	.
cord-337365-hugenn14	150	1	The	the	DT
cord-337365-hugenn14	150	2	activation	activation	NN
cord-337365-hugenn14	150	3	of	of	IN
cord-337365-hugenn14	150	4	NF	NF	NNP
cord-337365-hugenn14	150	5	-	-	HYPH
cord-337365-hugenn14	150	6	kB	kB	NNP
cord-337365-hugenn14	150	7	dependent	dependent	JJ
cord-337365-hugenn14	150	8	on	on	IN
cord-337365-hugenn14	150	9	ZIKV	ZIKV	NNP
cord-337365-hugenn14	150	10	induces	induce	VBZ
cord-337365-hugenn14	150	11	expression	expression	NN
cord-337365-hugenn14	150	12	of	of	IN
cord-337365-hugenn14	150	13	Drosophila	drosophila	JJ
cord-337365-hugenn14	150	14	stimulator	stimulator	NN
cord-337365-hugenn14	150	15	of	of	IN
cord-337365-hugenn14	150	16	interferon	interferon	NN
cord-337365-hugenn14	150	17	genes	gene	NNS
cord-337365-hugenn14	150	18	(	(	-LRB-
cord-337365-hugenn14	150	19	dSTING	dsting	JJ
cord-337365-hugenn14	150	20	)	)	-RRB-
cord-337365-hugenn14	150	21	in	in	IN
cord-337365-hugenn14	150	22	the	the	DT
cord-337365-hugenn14	150	23	brain	brain	NN
cord-337365-hugenn14	150	24	.	.	.
cord-337365-hugenn14	151	1	dSTING	dSTING	NNP
cord-337365-hugenn14	151	2	protects	protect	VBZ
cord-337365-hugenn14	151	3	against	against	IN
cord-337365-hugenn14	151	4	ZIKV	ZIKV	NNP
cord-337365-hugenn14	151	5	infection	infection	NN
cord-337365-hugenn14	151	6	by	by	IN
cord-337365-hugenn14	151	7	inducing	induce	VBG
cord-337365-hugenn14	151	8	autophagy	autophagy	NN
cord-337365-hugenn14	151	9	in	in	IN
cord-337365-hugenn14	151	10	the	the	DT
cord-337365-hugenn14	151	11	brain	brain	NN
cord-337365-hugenn14	151	12	.	.	.
cord-337365-hugenn14	152	1	Loss	loss	NN
cord-337365-hugenn14	152	2	of	of	IN
cord-337365-hugenn14	152	3	autophagy	autophagy	NN
cord-337365-hugenn14	152	4	leads	lead	VBZ
cord-337365-hugenn14	152	5	to	to	IN
cord-337365-hugenn14	152	6	increased	increase	VBN
cord-337365-hugenn14	152	7	viral	viral	JJ
cord-337365-hugenn14	152	8	load	load	NN
cord-337365-hugenn14	152	9	in	in	IN
cord-337365-hugenn14	152	10	the	the	DT
cord-337365-hugenn14	152	11	brain	brain	NN
cord-337365-hugenn14	152	12	and	and	CC
cord-337365-hugenn14	152	13	increases	increase	VBZ
cord-337365-hugenn14	152	14	infection	infection	NN
cord-337365-hugenn14	152	15	in	in	IN
cord-337365-hugenn14	152	16	Drosophila	Drosophila	NNP
cord-337365-hugenn14	152	17	[	[	-LRB-
cord-337365-hugenn14	152	18	38	38	CD
cord-337365-hugenn14	152	19	]	]	-RRB-
cord-337365-hugenn14	152	20	.	.	.
cord-337365-hugenn14	153	1	Multiple	multiple	JJ
cord-337365-hugenn14	153	2	microbial	microbial	JJ
cord-337365-hugenn14	153	3	infections	infection	NNS
cord-337365-hugenn14	153	4	activate	activate	VBP
cord-337365-hugenn14	153	5	NFkB	nfkb	JJ
cord-337365-hugenn14	153	6	-	-	HYPH
cord-337365-hugenn14	153	7	dependent	dependent	JJ
cord-337365-hugenn14	153	8	inflammatory	inflammatory	JJ
cord-337365-hugenn14	153	9	signaling	signaling	NN
cord-337365-hugenn14	153	10	cascades	cascade	NNS
cord-337365-hugenn14	153	11	,	,	,
cord-337365-hugenn14	153	12	which	which	WDT
cord-337365-hugenn14	153	13	induce	induce	VBP
cord-337365-hugenn14	153	14	transcription	transcription	NN
cord-337365-hugenn14	153	15	of	of	IN
cord-337365-hugenn14	153	16	downstream	downstream	JJ
cord-337365-hugenn14	153	17	antimicrobial	antimicrobial	JJ
cord-337365-hugenn14	153	18	effectors	effector	NNS
cord-337365-hugenn14	153	19	,	,	,
cord-337365-hugenn14	153	20	including	include	VBG
cord-337365-hugenn14	153	21	antimicrobial	antimicrobial	JJ
cord-337365-hugenn14	153	22	peptides	peptide	NNS
cord-337365-hugenn14	153	23	(	(	-LRB-
cord-337365-hugenn14	153	24	AMPs	AMPs	NNP
cord-337365-hugenn14	153	25	)	)	-RRB-
cord-337365-hugenn14	153	26	,	,	,
cord-337365-hugenn14	153	27	thereby	thereby	RB
cord-337365-hugenn14	153	28	reducing	reduce	VBG
cord-337365-hugenn14	153	29	or	or	CC
cord-337365-hugenn14	153	30	eliminating	eliminate	VBG
cord-337365-hugenn14	153	31	infection	infection	NN
cord-337365-hugenn14	153	32	[	[	-LRB-
cord-337365-hugenn14	153	33	39	39	CD
cord-337365-hugenn14	153	34	]	]	-RRB-
cord-337365-hugenn14	153	35	.	.	.
cord-337365-hugenn14	154	1	Endogenous	endogenous	JJ
cord-337365-hugenn14	154	2	,	,	,
cord-337365-hugenn14	154	3	bacterial	bacterial	JJ
cord-337365-hugenn14	154	4	-	-	HYPH
cord-337365-hugenn14	154	5	derived	derive	VBN
cord-337365-hugenn14	154	6	circulating	circulate	VBG
cord-337365-hugenn14	154	7	dinucleotides	dinucleotide	NNS
cord-337365-hugenn14	154	8	and	and	CC
cord-337365-hugenn14	154	9	increased	increase	VBN
cord-337365-hugenn14	154	10	expression	expression	NN
cord-337365-hugenn14	154	11	of	of	IN
cord-337365-hugenn14	154	12	STING	sting	NN
cord-337365-hugenn14	155	1	mRNA	mrna	NN
cord-337365-hugenn14	155	2	can	can	MD
cord-337365-hugenn14	155	3	activate	activate	VB
cord-337365-hugenn14	155	4	STING	STING	NNP
cord-337365-hugenn14	155	5	[	[	-LRB-
cord-337365-hugenn14	155	6	40	40	CD
cord-337365-hugenn14	155	7	]	]	-RRB-
cord-337365-hugenn14	155	8	.	.	.
cord-337365-hugenn14	156	1	From	from	IN
cord-337365-hugenn14	156	2	fruit	fruit	NN
cord-337365-hugenn14	156	3	flies	fly	NNS
cord-337365-hugenn14	156	4	to	to	IN
cord-337365-hugenn14	156	5	mammals	mammal	NNS
cord-337365-hugenn14	156	6	,	,	,
cord-337365-hugenn14	156	7	activation	activation	NN
cord-337365-hugenn14	156	8	of	of	IN
cord-337365-hugenn14	156	9	antimicrobial	antimicrobial	JJ
cord-337365-hugenn14	156	10	autophagy	autophagy	NN
cord-337365-hugenn14	156	11	protects	protect	VBZ
cord-337365-hugenn14	156	12	cells	cell	NNS
cord-337365-hugenn14	156	13	against	against	IN
cord-337365-hugenn14	156	14	a	a	DT
cord-337365-hugenn14	156	15	variety	variety	NN
cord-337365-hugenn14	156	16	of	of	IN
cord-337365-hugenn14	156	17	pathogens	pathogen	NNS
cord-337365-hugenn14	156	18	,	,	,
cord-337365-hugenn14	156	19	including	include	VBG
cord-337365-hugenn14	156	20	bacteria	bacteria	NNS
cord-337365-hugenn14	156	21	,	,	,
cord-337365-hugenn14	156	22	viruses	virus	NNS
cord-337365-hugenn14	156	23	,	,	,
cord-337365-hugenn14	156	24	and	and	CC
cord-337365-hugenn14	156	25	parasites	parasite	NNS
cord-337365-hugenn14	156	26	[	[	-LRB-
cord-337365-hugenn14	156	27	41	41	CD
cord-337365-hugenn14	156	28	,	,	,
cord-337365-hugenn14	156	29	42	42	CD
cord-337365-hugenn14	156	30	]	]	-RRB-
cord-337365-hugenn14	156	31	.	.	.
cord-337365-hugenn14	157	1	Studies	study	NNS
cord-337365-hugenn14	157	2	have	have	VBP
cord-337365-hugenn14	157	3	shown	show	VBN
cord-337365-hugenn14	157	4	that	that	IN
cord-337365-hugenn14	157	5	Drosophila	Drosophila	NNP
cord-337365-hugenn14	157	6	infected	infect	VBN
cord-337365-hugenn14	157	7	with	with	IN
cord-337365-hugenn14	157	8	ZIKV	ZIKV	NNP
cord-337365-hugenn14	157	9	induces	induce	VBZ
cord-337365-hugenn14	157	10	activation	activation	NN
cord-337365-hugenn14	157	11	of	of	IN
cord-337365-hugenn14	158	1	NF	NF	NNP
cord-337365-hugenn14	158	2	-	-	HYPH
cord-337365-hugenn14	158	3	kB	kB	NNP
cord-337365-hugenn14	158	4	signaling	signal	VBG
cord-337365-hugenn14	158	5	in	in	IN
cord-337365-hugenn14	158	6	the	the	DT
cord-337365-hugenn14	158	7	IMD	IMD	NNP
cord-337365-hugenn14	158	8	pathway	pathway	NN
cord-337365-hugenn14	158	9	,	,	,
cord-337365-hugenn14	158	10	thereby	thereby	RB
cord-337365-hugenn14	158	11	activating	activate	VBG
cord-337365-hugenn14	158	12	downstream	downstream	JJ
cord-337365-hugenn14	158	13	dSTING	dsting	JJ
cord-337365-hugenn14	158	14	.	.	.
cord-337365-hugenn14	159	1	dSTING	dSTING	NNP
cord-337365-hugenn14	159	2	can	can	MD
cord-337365-hugenn14	159	3	limit	limit	VB
cord-337365-hugenn14	159	4	intracellular	intracellular	JJ
cord-337365-hugenn14	159	5	pathogens	pathogen	NNS
cord-337365-hugenn14	159	6	by	by	IN
cord-337365-hugenn14	159	7	inducing	induce	VBG
cord-337365-hugenn14	159	8	autophagy	autophagy	NN
cord-337365-hugenn14	159	9	[	[	-LRB-
cord-337365-hugenn14	159	10	43	43	CD
cord-337365-hugenn14	159	11	]	]	-RRB-
cord-337365-hugenn14	159	12	.	.	.
cord-337365-hugenn14	160	1	Autophagy	Autophagy	NNP
cord-337365-hugenn14	160	2	protects	protect	VBZ
cord-337365-hugenn14	160	3	neurons	neuron	NNS
cord-337365-hugenn14	160	4	against	against	IN
cord-337365-hugenn14	160	5	a	a	DT
cord-337365-hugenn14	160	6	variety	variety	NN
cord-337365-hugenn14	160	7	of	of	IN
cord-337365-hugenn14	160	8	stressors	stressor	NNS
cord-337365-hugenn14	160	9	,	,	,
cord-337365-hugenn14	160	10	including	include	VBG
cord-337365-hugenn14	160	11	viral	viral	JJ
cord-337365-hugenn14	160	12	infections	infection	NNS
cord-337365-hugenn14	160	13	.	.	.
cord-337365-hugenn14	161	1	Autophagy	Autophagy	NNP
cord-337365-hugenn14	161	2	clears	clear	VBZ
cord-337365-hugenn14	161	3	infection	infection	NN
cord-337365-hugenn14	161	4	by	by	IN
cord-337365-hugenn14	161	5	capturing	capture	VBG
cord-337365-hugenn14	161	6	pathogens	pathogen	NNS
cord-337365-hugenn14	161	7	,	,	,
cord-337365-hugenn14	161	8	including	include	VBG
cord-337365-hugenn14	161	9	viruses	virus	NNS
cord-337365-hugenn14	161	10	,	,	,
cord-337365-hugenn14	161	11	in	in	IN
cord-337365-hugenn14	161	12	the	the	DT
cord-337365-hugenn14	161	13	cell	cell	NN
cord-337365-hugenn14	161	14	without	without	IN
cord-337365-hugenn14	161	15	causing	cause	VBG
cord-337365-hugenn14	161	16	cell	cell	NN
cord-337365-hugenn14	161	17	death	death	NN
cord-337365-hugenn14	161	18	,	,	,
cord-337365-hugenn14	161	19	which	which	WDT
cord-337365-hugenn14	161	20	is	be	VBZ
cord-337365-hugenn14	161	21	beneficial	beneficial	JJ
cord-337365-hugenn14	161	22	for	for	IN
cord-337365-hugenn14	161	23	mature	mature	JJ
cord-337365-hugenn14	161	24	neurons	neuron	NNS
cord-337365-hugenn14	161	25	[	[	-LRB-
cord-337365-hugenn14	161	26	42	42	CD
cord-337365-hugenn14	161	27	,	,	,
cord-337365-hugenn14	161	28	44	44	CD
cord-337365-hugenn14	161	29	]	]	-RRB-
cord-337365-hugenn14	161	30	.	.	.
cord-337365-hugenn14	162	1	Previous	previous	JJ
cord-337365-hugenn14	162	2	studies	study	NNS
cord-337365-hugenn14	162	3	used	use	VBD
cord-337365-hugenn14	162	4	heat	heat	NN
cord-337365-hugenn14	162	5	shock	shock	NN
cord-337365-hugenn14	162	6	-	-	HYPH
cord-337365-hugenn14	162	7	inducible	inducible	JJ
cord-337365-hugenn14	162	8	gal4	gal4	NN
cord-337365-hugenn14	162	9	(	(	-LRB-
cord-337365-hugenn14	162	10	HS	HS	NNP
cord-337365-hugenn14	162	11	-	-	HYPH
cord-337365-hugenn14	162	12	gal4	gal4	NNP
cord-337365-hugenn14	162	13	)	)	-RRB-
cord-337365-hugenn14	162	14	to	to	TO
cord-337365-hugenn14	162	15	silence	silence	VB
cord-337365-hugenn14	162	16	autophagy	autophagy	VB
cord-337365-hugenn14	162	17	core	core	NN
cord-337365-hugenn14	162	18	genes	gene	NNS
cord-337365-hugenn14	162	19	Atg5	atg5	JJ
cord-337365-hugenn14	162	20	and	and	CC
cord-337365-hugenn14	162	21	Atg7	Atg7	NNP
cord-337365-hugenn14	162	22	in	in	IN
cord-337365-hugenn14	162	23	vivo	vivo	NN
cord-337365-hugenn14	162	24	[	[	-LRB-
cord-337365-hugenn14	162	25	45	45	CD
cord-337365-hugenn14	162	26	]	]	-RRB-
cord-337365-hugenn14	162	27	and	and	CC
cord-337365-hugenn14	162	28	found	find	VBD
cord-337365-hugenn14	162	29	that	that	IN
cord-337365-hugenn14	162	30	the	the	DT
cord-337365-hugenn14	162	31	virus	virus	NN
cord-337365-hugenn14	162	32	titer	titer	NN
cord-337365-hugenn14	162	33	of	of	IN
cord-337365-hugenn14	162	34	ZIKV	ZIKV	NNP
cord-337365-hugenn14	162	35	in	in	IN
cord-337365-hugenn14	162	36	Drosophila	Drosophila	NNP
cord-337365-hugenn14	162	37	is	be	VBZ
cord-337365-hugenn14	162	38	significantly	significantly	RB
cord-337365-hugenn14	162	39	increased	increase	VBN
cord-337365-hugenn14	162	40	.	.	.
cord-337365-hugenn14	163	1	Relish	Relish	NNP
cord-337365-hugenn14	163	2	is	be	VBZ
cord-337365-hugenn14	163	3	a	a	DT
cord-337365-hugenn14	163	4	transcription	transcription	NN
cord-337365-hugenn14	163	5	factor	factor	NN
cord-337365-hugenn14	163	6	of	of	IN
cord-337365-hugenn14	163	7	NF	NF	NNP
cord-337365-hugenn14	163	8	-	-	HYPH
cord-337365-hugenn14	163	9	kB	kB	NNP
cord-337365-hugenn14	163	10	in	in	IN
cord-337365-hugenn14	163	11	the	the	DT
cord-337365-hugenn14	163	12	IMD	IMD	NNP
cord-337365-hugenn14	163	13	pathway	pathway	NN
cord-337365-hugenn14	163	14	.	.	.
cord-337365-hugenn14	164	1	Using	use	VBG
cord-337365-hugenn14	164	2	a	a	DT
cord-337365-hugenn14	164	3	validated	validate	VBN
cord-337365-hugenn14	164	4	RNAi	RNAi	NNP
cord-337365-hugenn14	164	5	line	line	NN
cord-337365-hugenn14	164	6	which	which	WDT
cord-337365-hugenn14	164	7	specifically	specifically	RB
cord-337365-hugenn14	164	8	removes	remove	VBZ
cord-337365-hugenn14	164	9	Relish	relish	NN
cord-337365-hugenn14	164	10	from	from	IN
cord-337365-hugenn14	164	11	neurons	neuron	NNS
cord-337365-hugenn14	164	12	or	or	CC
cord-337365-hugenn14	164	13	glial	glial	JJ
cord-337365-hugenn14	164	14	cells	cell	NNS
cord-337365-hugenn14	164	15	in	in	IN
cord-337365-hugenn14	164	16	vivo	vivo	NN
cord-337365-hugenn14	164	17	,	,	,
cord-337365-hugenn14	164	18	known	know	VBN
cord-337365-hugenn14	164	19	as	as	IN
cord-337365-hugenn14	164	20	a	a	DT
cord-337365-hugenn14	164	21	neuron	neuron	NN
cord-337365-hugenn14	164	22	-	-	HYPH
cord-337365-hugenn14	164	23	specific	specific	JJ
cord-337365-hugenn14	164	24	gal4	gal4	NN
cord-337365-hugenn14	164	25	driver	driver	NN
cord-337365-hugenn14	164	26	(	(	-LRB-
cord-337365-hugenn14	164	27	elav	elav	JJ
cord-337365-hugenn14	164	28	-	-	HYPH
cord-337365-hugenn14	164	29	gal4	gal4	NNP
cord-337365-hugenn14	164	30	)	)	-RRB-
cord-337365-hugenn14	164	31	or	or	CC
cord-337365-hugenn14	164	32	a	a	DT
cord-337365-hugenn14	164	33	glia	glia	NN
cord-337365-hugenn14	164	34	-	-	HYPH
cord-337365-hugenn14	164	35	specific	specific	JJ
cord-337365-hugenn14	164	36	gal4	gal4	NN
cord-337365-hugenn14	164	37	driver	driver	NN
cord-337365-hugenn14	165	1	(	(	-LRB-
cord-337365-hugenn14	165	2	Repo	Repo	NNP
cord-337365-hugenn14	165	3	-	-	HYPH
cord-337365-hugenn14	165	4	gal4	gal4	NNP
cord-337365-hugenn14	165	5	)	)	-RRB-
cord-337365-hugenn14	165	6	,	,	,
cord-337365-hugenn14	165	7	respectively	respectively	RB
cord-337365-hugenn14	165	8	[	[	-LRB-
cord-337365-hugenn14	165	9	46	46	CD
cord-337365-hugenn14	165	10	]	]	-RRB-
cord-337365-hugenn14	165	11	,	,	,
cord-337365-hugenn14	165	12	increased	increase	VBN
cord-337365-hugenn14	165	13	viral	viral	JJ
cord-337365-hugenn14	165	14	infection	infection	NN
cord-337365-hugenn14	165	15	.	.	.
cord-337365-hugenn14	166	1	In	in	IN
cord-337365-hugenn14	166	2	mammals	mammal	NNS
cord-337365-hugenn14	166	3	,	,	,
cord-337365-hugenn14	166	4	autophagy	autophagy	NN
cord-337365-hugenn14	166	5	limits	limit	VBZ
cord-337365-hugenn14	166	6	the	the	DT
cord-337365-hugenn14	166	7	replication	replication	NN
cord-337365-hugenn14	166	8	or	or	CC
cord-337365-hugenn14	166	9	pathogenesis	pathogenesis	NN
cord-337365-hugenn14	166	10	of	of	IN
cord-337365-hugenn14	166	11	herpes	herpes	NN
cord-337365-hugenn14	166	12	simplex	simplex	NNP
cord-337365-hugenn14	166	13	virus	virus	NN
cord-337365-hugenn14	166	14	type	type	NN
cord-337365-hugenn14	166	15	1	1	CD
cord-337365-hugenn14	166	16	(	(	-LRB-
cord-337365-hugenn14	166	17	HSV-1	hsv-1	NN
cord-337365-hugenn14	166	18	)	)	-RRB-
cord-337365-hugenn14	167	1	[	[	-LRB-
cord-337365-hugenn14	167	2	47	47	CD
cord-337365-hugenn14	167	3	]	]	-RRB-
cord-337365-hugenn14	167	4	.	.	.
cord-337365-hugenn14	168	1	Intracellular	Intracellular	NNP
cord-337365-hugenn14	168	2	receptors	receptor	NNS
cord-337365-hugenn14	168	3	,	,	,
cord-337365-hugenn14	168	4	such	such	JJ
cord-337365-hugenn14	168	5	as	as	IN
cord-337365-hugenn14	168	6	retinoic	retinoic	JJ
cord-337365-hugenn14	168	7	acid	acid	NN
cord-337365-hugenn14	168	8	-	-	HYPH
cord-337365-hugenn14	168	9	inducible	inducible	JJ
cord-337365-hugenn14	168	10	gene	gene	NN
cord-337365-hugenn14	168	11	-	-	:
cord-337365-hugenn14	168	12	I	i	NN
cord-337365-hugenn14	168	13	(	(	-LRB-
cord-337365-hugenn14	168	14	RIG	rig	NN
cord-337365-hugenn14	168	15	-	-	:
cord-337365-hugenn14	168	16	I	i	NN
cord-337365-hugenn14	168	17	)	)	-RRB-
cord-337365-hugenn14	168	18	and	and	CC
cord-337365-hugenn14	168	19	melanoma	melanoma	NN
cord-337365-hugenn14	168	20	differentiation	differentiation	NN
cord-337365-hugenn14	168	21	-	-	HYPH
cord-337365-hugenn14	168	22	associated	associate	VBN
cord-337365-hugenn14	168	23	protein	protein	NN
cord-337365-hugenn14	168	24	5	5	CD
cord-337365-hugenn14	168	25	(	(	-LRB-
cord-337365-hugenn14	168	26	MDA-5	MDA-5	NNP
cord-337365-hugenn14	168	27	)	)	-RRB-
cord-337365-hugenn14	168	28	,	,	,
cord-337365-hugenn14	168	29	collectively	collectively	RB
cord-337365-hugenn14	168	30	referred	refer	VBD
cord-337365-hugenn14	168	31	to	to	IN
cord-337365-hugenn14	168	32	as	as	IN
cord-337365-hugenn14	168	33	RIG	rig	NN
cord-337365-hugenn14	168	34	-	-	HYPH
cord-337365-hugenn14	168	35	I	i	NN
cord-337365-hugenn14	168	36	-	-	HYPH
cord-337365-hugenn14	168	37	like	like	JJ
cord-337365-hugenn14	168	38	receptors	receptor	NNS
cord-337365-hugenn14	168	39	(	(	-LRB-
cord-337365-hugenn14	168	40	RLRs	RLRs	NNP
cord-337365-hugenn14	168	41	)	)	-RRB-
cord-337365-hugenn14	168	42	,	,	,
cord-337365-hugenn14	168	43	can	can	MD
cord-337365-hugenn14	168	44	also	also	RB
cord-337365-hugenn14	168	45	detect	detect	VB
cord-337365-hugenn14	168	46	cytoplasmic	cytoplasmic	JJ
cord-337365-hugenn14	168	47	viruses	virus	NNS
cord-337365-hugenn14	168	48	nucleic	nucleic	JJ
cord-337365-hugenn14	168	49	acid	acid	NN
cord-337365-hugenn14	168	50	[	[	-LRB-
cord-337365-hugenn14	168	51	48	48	CD
cord-337365-hugenn14	168	52	]	]	-RRB-
cord-337365-hugenn14	168	53	.	.	.
cord-337365-hugenn14	169	1	Using	use	VBG
cord-337365-hugenn14	169	2	the	the	DT
cord-337365-hugenn14	169	3	advantages	advantage	NNS
cord-337365-hugenn14	169	4	of	of	IN
cord-337365-hugenn14	169	5	Drosophila	Drosophila	NNP
cord-337365-hugenn14	169	6	,	,	,
cord-337365-hugenn14	169	7	the	the	DT
cord-337365-hugenn14	169	8	study	study	NN
cord-337365-hugenn14	169	9	found	find	VBD
cord-337365-hugenn14	169	10	that	that	IN
cord-337365-hugenn14	169	11	the	the	DT
cord-337365-hugenn14	169	12	PRR	PRR	NNP
cord-337365-hugenn14	169	13	-	-	HYPH
cord-337365-hugenn14	169	14	autophagy	autophagy	NN
cord-337365-hugenn14	169	15	axis	axis	NN
cord-337365-hugenn14	169	16	plays	play	VBZ
cord-337365-hugenn14	169	17	an	an	DT
cord-337365-hugenn14	169	18	important	important	JJ
cord-337365-hugenn14	169	19	role	role	NN
cord-337365-hugenn14	169	20	in	in	IN
cord-337365-hugenn14	169	21	host	host	NN
cord-337365-hugenn14	169	22	defense	defense	NN
cord-337365-hugenn14	169	23	[	[	-LRB-
cord-337365-hugenn14	169	24	49	49	CD
cord-337365-hugenn14	169	25	]	]	-RRB-
cord-337365-hugenn14	169	26	.	.	.
cord-337365-hugenn14	170	1	Fifty	fifty	CD
cord-337365-hugenn14	170	2	percent	percent	NN
cord-337365-hugenn14	170	3	of	of	IN
cord-337365-hugenn14	170	4	patients	patient	NNS
cord-337365-hugenn14	170	5	with	with	IN
cord-337365-hugenn14	170	6	neurotropic	neurotropic	NNP
cord-337365-hugenn14	170	7	WNV	WNV	NNP
cord-337365-hugenn14	170	8	infection	infection	NN
cord-337365-hugenn14	170	9	show	show	VBP
cord-337365-hugenn14	170	10	chronic	chronic	JJ
cord-337365-hugenn14	170	11	cognitive	cognitive	JJ
cord-337365-hugenn14	170	12	sequelae	sequela	NNS
cord-337365-hugenn14	170	13	[	[	-LRB-
cord-337365-hugenn14	170	14	50	50	CD
cord-337365-hugenn14	170	15	]	]	-RRB-
cord-337365-hugenn14	170	16	.	.	.
cord-337365-hugenn14	171	1	Patients	patient	NNS
cord-337365-hugenn14	171	2	who	who	WP
cord-337365-hugenn14	171	3	survive	survive	VBP
cord-337365-hugenn14	171	4	after	after	IN
cord-337365-hugenn14	171	5	infection	infection	NN
cord-337365-hugenn14	171	6	with	with	IN
cord-337365-hugenn14	171	7	WNV	WNV	NNP
cord-337365-hugenn14	171	8	usually	usually	RB
cord-337365-hugenn14	171	9	present	present	JJ
cord-337365-hugenn14	171	10	with	with	IN
cord-337365-hugenn14	171	11	visual	visual	JJ
cord-337365-hugenn14	171	12	-	-	HYPH
cord-337365-hugenn14	171	13	spatial	spatial	JJ
cord-337365-hugenn14	171	14	processing	processing	NN
cord-337365-hugenn14	171	15	disorders	disorder	NNS
cord-337365-hugenn14	171	16	and	and	CC
cord-337365-hugenn14	171	17	impaired	impaired	JJ
cord-337365-hugenn14	171	18	memory	memory	NN
cord-337365-hugenn14	171	19	function	function	NN
cord-337365-hugenn14	171	20	[	[	-LRB-
cord-337365-hugenn14	171	21	50	50	CD
cord-337365-hugenn14	171	22	,	,	,
cord-337365-hugenn14	171	23	51	51	CD
cord-337365-hugenn14	171	24	]	]	-RRB-
cord-337365-hugenn14	171	25	.	.	.
cord-337365-hugenn14	172	1	Studies	study	NNS
cord-337365-hugenn14	172	2	have	have	VBP
cord-337365-hugenn14	172	3	shown	show	VBN
cord-337365-hugenn14	172	4	that	that	DT
cord-337365-hugenn14	172	5	complement	complement	NN
cord-337365-hugenn14	172	6	C3	c3	NN
cord-337365-hugenn14	172	7	and	and	CC
cord-337365-hugenn14	172	8	C3aR	c3ar	RB
cord-337365-hugenn14	172	9	mediate	mediate	VB
cord-337365-hugenn14	172	10	the	the	DT
cord-337365-hugenn14	172	11	loss	loss	NN
cord-337365-hugenn14	172	12	of	of	IN
cord-337365-hugenn14	172	13	presynaptic	presynaptic	JJ
cord-337365-hugenn14	172	14	ends	end	NNS
cord-337365-hugenn14	172	15	in	in	IN
cord-337365-hugenn14	172	16	mouse	mouse	NN
cord-337365-hugenn14	172	17	hippocampus	hippocampus	NNP
cord-337365-hugenn14	172	18	(	(	-LRB-
cord-337365-hugenn14	172	19	see	see	VB
cord-337365-hugenn14	172	20	Fig	Fig	NNP
cord-337365-hugenn14	172	21	.	.	NNP
cord-337365-hugenn14	172	22	2	2	CD
cord-337365-hugenn14	172	23	)	)	-RRB-
cord-337365-hugenn14	172	24	.	.	.
cord-337365-hugenn14	173	1	Mice	mouse	NNS
cord-337365-hugenn14	173	2	demonstrate	demonstrate	VBP
cord-337365-hugenn14	173	3	spatial	spatial	JJ
cord-337365-hugenn14	173	4	learning	learning	NN
cord-337365-hugenn14	173	5	in	in	IN
cord-337365-hugenn14	173	6	the	the	DT
cord-337365-hugenn14	173	7	recovery	recovery	NN
cord-337365-hugenn14	173	8	period	period	NN
cord-337365-hugenn14	173	9	of	of	IN
cord-337365-hugenn14	173	10	neurological	neurological	JJ
cord-337365-hugenn14	173	11	invasive	invasive	JJ
cord-337365-hugenn14	173	12	diseases	disease	NNS
cord-337365-hugenn14	173	13	in	in	IN
cord-337365-hugenn14	173	14	West	West	NNP
cord-337365-hugenn14	173	15	Nile	Nile	NNP
cord-337365-hugenn14	173	16	.	.	.
cord-337365-hugenn14	174	1	Both	both	DT
cord-337365-hugenn14	174	2	neurons	neuron	NNS
cord-337365-hugenn14	174	3	and	and	CC
cord-337365-hugenn14	174	4	microglia	microglia	NNP
cord-337365-hugenn14	174	5	express	express	NNP
cord-337365-hugenn14	174	6	C3aR	C3aR	NNP
cord-337365-hugenn14	174	7	,	,	,
cord-337365-hugenn14	174	8	which	which	WDT
cord-337365-hugenn14	174	9	recognizes	recognize	VBZ
cord-337365-hugenn14	174	10	C3	C3	NNP
cord-337365-hugenn14	174	11	cleavage	cleavage	NN
cord-337365-hugenn14	174	12	products	product	NNS
cord-337365-hugenn14	174	13	.	.	.
cord-337365-hugenn14	175	1	C3	C3	NNP
cord-337365-hugenn14	175	2	and	and	CC
cord-337365-hugenn14	175	3	its	-PRON-	PRP$
cord-337365-hugenn14	175	4	cleavage	cleavage	NN
cord-337365-hugenn14	175	5	products	product	NNS
cord-337365-hugenn14	175	6	attract	attract	VBP
cord-337365-hugenn14	175	7	microglia	microglia	NNS
cord-337365-hugenn14	175	8	to	to	TO
cord-337365-hugenn14	175	9	gather	gather	VB
cord-337365-hugenn14	175	10	around	around	IN
cord-337365-hugenn14	175	11	the	the	DT
cord-337365-hugenn14	175	12	neurons	neuron	NNS
cord-337365-hugenn14	175	13	to	to	TO
cord-337365-hugenn14	175	14	exert	exert	VB
cord-337365-hugenn14	175	15	phagocytosis	phagocytosis	NN
cord-337365-hugenn14	175	16	activity	activity	NN
cord-337365-hugenn14	175	17	and	and	CC
cord-337365-hugenn14	175	18	to	to	TO
cord-337365-hugenn14	175	19	clear	clear	VB
cord-337365-hugenn14	175	20	the	the	DT
cord-337365-hugenn14	175	21	presynaptic	presynaptic	JJ
cord-337365-hugenn14	175	22	ends	end	NNS
cord-337365-hugenn14	175	23	.	.	.
cord-337365-hugenn14	176	1	In	in	IN
cord-337365-hugenn14	176	2	the	the	DT
cord-337365-hugenn14	176	3	situation	situation	NN
cord-337365-hugenn14	176	4	of	of	IN
cord-337365-hugenn14	176	5	a	a	DT
cord-337365-hugenn14	176	6	neurotropic	neurotropic	NNP
cord-337365-hugenn14	176	7	virus	virus	NN
cord-337365-hugenn14	176	8	infection	infection	NN
cord-337365-hugenn14	176	9	,	,	,
cord-337365-hugenn14	176	10	clearance	clearance	NN
cord-337365-hugenn14	176	11	of	of	IN
cord-337365-hugenn14	176	12	the	the	DT
cord-337365-hugenn14	176	13	presynaptic	presynaptic	JJ
cord-337365-hugenn14	176	14	end	end	NN
cord-337365-hugenn14	176	15	may	may	MD
cord-337365-hugenn14	176	16	prevent	prevent	VB
cord-337365-hugenn14	176	17	trans	trans	JJ
cord-337365-hugenn14	176	18	-	-	JJ
cord-337365-hugenn14	176	19	synaptic	synaptic	JJ
cord-337365-hugenn14	176	20	spread	spread	NN
cord-337365-hugenn14	176	21	of	of	IN
cord-337365-hugenn14	176	22	the	the	DT
cord-337365-hugenn14	176	23	virus	virus	NN
cord-337365-hugenn14	176	24	and	and	CC
cord-337365-hugenn14	176	25	stop	stop	VB
cord-337365-hugenn14	176	26	abnormal	abnormal	JJ
cord-337365-hugenn14	176	27	signals	signal	NNS
cord-337365-hugenn14	176	28	from	from	IN
cord-337365-hugenn14	176	29	infected	infected	JJ
cord-337365-hugenn14	176	30	neurons	neuron	NNS
cord-337365-hugenn14	176	31	[	[	-LRB-
cord-337365-hugenn14	176	32	52	52	CD
cord-337365-hugenn14	176	33	]	]	-RRB-
cord-337365-hugenn14	176	34	.	.	.
cord-337365-hugenn14	177	1	Infected	infected	JJ
cord-337365-hugenn14	177	2	and	and	CC
cord-337365-hugenn14	177	3	activated	activate	VBN
cord-337365-hugenn14	177	4	microglia	microglia	NNS
cord-337365-hugenn14	177	5	in	in	IN
cord-337365-hugenn14	177	6	the	the	DT
cord-337365-hugenn14	177	7	CNS	CNS	NNP
cord-337365-hugenn14	177	8	persist	persist	VBP
cord-337365-hugenn14	177	9	for	for	IN
cord-337365-hugenn14	177	10	more	more	JJR
cord-337365-hugenn14	177	11	than	than	IN
cord-337365-hugenn14	177	12	12	12	CD
cord-337365-hugenn14	177	13	months	month	NNS
cord-337365-hugenn14	177	14	after	after	IN
cord-337365-hugenn14	177	15	receiving	receive	VBG
cord-337365-hugenn14	177	16	antiviral	antiviral	JJ
cord-337365-hugenn14	177	17	therapy	therapy	NN
cord-337365-hugenn14	177	18	in	in	IN
cord-337365-hugenn14	177	19	patients	patient	NNS
cord-337365-hugenn14	177	20	with	with	IN
cord-337365-hugenn14	177	21	HSV	HSV	NNP
cord-337365-hugenn14	177	22	encephalitis	encephalitis	NN
cord-337365-hugenn14	177	23	[	[	-LRB-
cord-337365-hugenn14	177	24	53	53	CD
cord-337365-hugenn14	177	25	]	]	-RRB-
cord-337365-hugenn14	177	26	.	.	.
cord-337365-hugenn14	178	1	This	this	DT
cord-337365-hugenn14	178	2	may	may	MD
cord-337365-hugenn14	178	3	lead	lead	VB
cord-337365-hugenn14	178	4	to	to	IN
cord-337365-hugenn14	178	5	chronic	chronic	JJ
cord-337365-hugenn14	178	6	damage	damage	NN
cord-337365-hugenn14	178	7	to	to	IN
cord-337365-hugenn14	178	8	the	the	DT
cord-337365-hugenn14	178	9	CNS	CNS	NNP
cord-337365-hugenn14	178	10	.	.	.
cord-337365-hugenn14	179	1	Microglia	Microglia	NNP
cord-337365-hugenn14	179	2	can	can	MD
cord-337365-hugenn14	179	3	produce	produce	VB
cord-337365-hugenn14	179	4	TNFα	TNFα	NNS
cord-337365-hugenn14	179	5	[	[	-LRB-
cord-337365-hugenn14	179	6	35	35	CD
cord-337365-hugenn14	179	7	,	,	,
cord-337365-hugenn14	179	8	36	36	CD
cord-337365-hugenn14	179	9	]	]	-RRB-
cord-337365-hugenn14	179	10	.	.	.
cord-337365-hugenn14	180	1	Local	local	JJ
cord-337365-hugenn14	180	2	increase	increase	NN
cord-337365-hugenn14	180	3	of	of	IN
cord-337365-hugenn14	180	4	TNFα	TNFα	NNS
cord-337365-hugenn14	180	5	in	in	IN
cord-337365-hugenn14	180	6	the	the	DT
cord-337365-hugenn14	180	7	hippocampal	hippocampal	JJ
cord-337365-hugenn14	180	8	dentate	dentate	NN
cord-337365-hugenn14	180	9	gyrus	gyrus	NNP
cord-337365-hugenn14	180	10	activates	activate	VBZ
cord-337365-hugenn14	180	11	astrocyte	astrocyte	DT
cord-337365-hugenn14	181	1	TNF	TNF	NNP
cord-337365-hugenn14	181	2	receptor	receptor	NN
cord-337365-hugenn14	181	3	type	type	NN
cord-337365-hugenn14	181	4	1	1	CD
cord-337365-hugenn14	181	5	(	(	-LRB-
cord-337365-hugenn14	181	6	TNFR1	TNFR1	NNP
cord-337365-hugenn14	181	7	)	)	-RRB-
cord-337365-hugenn14	181	8	,	,	,
cord-337365-hugenn14	181	9	which	which	WDT
cord-337365-hugenn14	181	10	in	in	IN
cord-337365-hugenn14	181	11	turn	turn	NN
cord-337365-hugenn14	181	12	triggers	trigger	VBZ
cord-337365-hugenn14	181	13	an	an	DT
cord-337365-hugenn14	181	14	astrocyte	astrocyte	JJ
cord-337365-hugenn14	181	15	-	-	HYPH
cord-337365-hugenn14	181	16	neuron	neuron	NN
cord-337365-hugenn14	181	17	signaling	signaling	NN
cord-337365-hugenn14	181	18	cascade	cascade	NN
cord-337365-hugenn14	181	19	that	that	WDT
cord-337365-hugenn14	181	20	results	result	VBZ
cord-337365-hugenn14	181	21	in	in	IN
cord-337365-hugenn14	181	22	persistent	persistent	JJ
cord-337365-hugenn14	181	23	functional	functional	JJ
cord-337365-hugenn14	181	24	modification	modification	NN
cord-337365-hugenn14	181	25	of	of	IN
cord-337365-hugenn14	181	26	hippocampal	hippocampal	JJ
cord-337365-hugenn14	181	27	excitatory	excitatory	JJ
cord-337365-hugenn14	181	28	synapses	synapsis	NNS
cord-337365-hugenn14	181	29	which	which	WDT
cord-337365-hugenn14	181	30	can	can	MD
cord-337365-hugenn14	181	31	lead	lead	VB
cord-337365-hugenn14	181	32	to	to	IN
cord-337365-hugenn14	181	33	cognitive	cognitive	JJ
cord-337365-hugenn14	181	34	disturbance	disturbance	NN
cord-337365-hugenn14	181	35	[	[	-LRB-
cord-337365-hugenn14	181	36	54	54	CD
cord-337365-hugenn14	181	37	]	]	-RRB-
cord-337365-hugenn14	181	38	.	.	.
cord-337365-hugenn14	182	1	Glutamatergic	Glutamatergic	NNP
cord-337365-hugenn14	182	2	gliotransmission	gliotransmission	NN
cord-337365-hugenn14	182	3	provides	provide	VBZ
cord-337365-hugenn14	182	4	a	a	DT
cord-337365-hugenn14	182	5	stimulatory	stimulatory	JJ
cord-337365-hugenn14	182	6	input	input	NN
cord-337365-hugenn14	182	7	to	to	IN
cord-337365-hugenn14	182	8	excitatory	excitatory	JJ
cord-337365-hugenn14	182	9	synapses	synapsis	NNS
cord-337365-hugenn14	182	10	in	in	IN
cord-337365-hugenn14	182	11	the	the	DT
cord-337365-hugenn14	182	12	hippocampal	hippocampal	JJ
cord-337365-hugenn14	182	13	dentate	dentate	NN
cord-337365-hugenn14	182	14	gyrus	gyrus	NNP
cord-337365-hugenn14	182	15	.	.	.
cord-337365-hugenn14	183	1	TNFα	TNFα	NNP
cord-337365-hugenn14	183	2	critically	critically	RB
cord-337365-hugenn14	183	3	controls	control	VBZ
cord-337365-hugenn14	183	4	the	the	DT
cord-337365-hugenn14	183	5	process	process	NN
cord-337365-hugenn14	183	6	which	which	WDT
cord-337365-hugenn14	183	7	may	may	MD
cord-337365-hugenn14	183	8	influence	influence	VB
cord-337365-hugenn14	183	9	synaptic	synaptic	JJ
cord-337365-hugenn14	183	10	transmission	transmission	NN
cord-337365-hugenn14	183	11	and	and	CC
cord-337365-hugenn14	183	12	plasticity	plasticity	NN
cord-337365-hugenn14	183	13	[	[	-LRB-
cord-337365-hugenn14	183	14	55	55	CD
cord-337365-hugenn14	183	15	]	]	-RRB-
cord-337365-hugenn14	183	16	.	.	.
cord-337365-hugenn14	184	1	This	this	DT
cord-337365-hugenn14	184	2	suggests	suggest	VBZ
cord-337365-hugenn14	184	3	that	that	IN
cord-337365-hugenn14	184	4	microglia	microglia	NN
cord-337365-hugenn14	184	5	may	may	MD
cord-337365-hugenn14	184	6	also	also	RB
cord-337365-hugenn14	184	7	affect	affect	VB
cord-337365-hugenn14	184	8	synaptic	synaptic	JJ
cord-337365-hugenn14	184	9	function	function	NN
cord-337365-hugenn14	184	10	through	through	IN
cord-337365-hugenn14	184	11	cytokines	cytokine	NNS
cord-337365-hugenn14	184	12	.	.	.
cord-337365-hugenn14	185	1	The	the	DT
cord-337365-hugenn14	185	2	unprecedented	unprecedented	JJ
cord-337365-hugenn14	185	3	re	re	NN
cord-337365-hugenn14	185	4	-	-	NN
cord-337365-hugenn14	185	5	emergence	emergence	NN
cord-337365-hugenn14	185	6	of	of	IN
cord-337365-hugenn14	185	7	the	the	DT
cord-337365-hugenn14	185	8	Zika	Zika	NNP
cord-337365-hugenn14	185	9	virus	virus	NN
cord-337365-hugenn14	185	10	(	(	-LRB-
cord-337365-hugenn14	185	11	ZIKV	ZIKV	NNP
cord-337365-hugenn14	185	12	)	)	-RRB-
cord-337365-hugenn14	185	13	virus	virus	NN
cord-337365-hugenn14	185	14	has	have	VBZ
cord-337365-hugenn14	185	15	shocked	shock	VBN
cord-337365-hugenn14	185	16	the	the	DT
cord-337365-hugenn14	185	17	world	world	NN
cord-337365-hugenn14	185	18	,	,	,
cord-337365-hugenn14	185	19	and	and	CC
cord-337365-hugenn14	185	20	reports	report	NNS
cord-337365-hugenn14	185	21	on	on	IN
cord-337365-hugenn14	185	22	microcephaly	microcephaly	NNS
cord-337365-hugenn14	185	23	in	in	IN
cord-337365-hugenn14	185	24	Brazil	Brazil	NNP
cord-337365-hugenn14	185	25	are	be	VBP
cord-337365-hugenn14	185	26	also	also	RB
cord-337365-hugenn14	185	27	increasing	increase	VBG
cord-337365-hugenn14	185	28	[	[	-LRB-
cord-337365-hugenn14	185	29	56	56	CD
cord-337365-hugenn14	185	30	]	]	-RRB-
cord-337365-hugenn14	185	31	(	(	-LRB-
cord-337365-hugenn14	185	32	see	see	VB
cord-337365-hugenn14	185	33	Fig	Fig	NNP
cord-337365-hugenn14	185	34	.	.	NNP
cord-337365-hugenn14	185	35	2	2	CD
cord-337365-hugenn14	185	36	)	)	-RRB-
cord-337365-hugenn14	185	37	.	.	.
cord-337365-hugenn14	186	1	In	in	IN
cord-337365-hugenn14	186	2	Brazil	Brazil	NNP
cord-337365-hugenn14	186	3	,	,	,
cord-337365-hugenn14	186	4	the	the	DT
cord-337365-hugenn14	186	5	incidence	incidence	NN
cord-337365-hugenn14	186	6	of	of	IN
cord-337365-hugenn14	186	7	fetal	fetal	JJ
cord-337365-hugenn14	186	8	microcephaly	microcephaly	NNS
cord-337365-hugenn14	186	9	in	in	IN
cord-337365-hugenn14	186	10	ZIKV	ZIKV	NNP
cord-337365-hugenn14	186	11	-	-	HYPH
cord-337365-hugenn14	186	12	infected	infect	VBN
cord-337365-hugenn14	186	13	pregnant	pregnant	JJ
cord-337365-hugenn14	186	14	women	woman	NNS
cord-337365-hugenn14	186	15	is	be	VBZ
cord-337365-hugenn14	186	16	approximately	approximately	RB
cord-337365-hugenn14	186	17	12.8	12.8	CD
cord-337365-hugenn14	186	18	%	%	NN
cord-337365-hugenn14	186	19	[	[	-LRB-
cord-337365-hugenn14	186	20	57	57	CD
cord-337365-hugenn14	186	21	]	]	-RRB-
cord-337365-hugenn14	186	22	.	.	.
cord-337365-hugenn14	187	1	Surprisingly	surprisingly	RB
cord-337365-hugenn14	187	2	,	,	,
cord-337365-hugenn14	187	3	there	there	EX
cord-337365-hugenn14	187	4	have	have	VBP
cord-337365-hugenn14	187	5	been	be	VBN
cord-337365-hugenn14	187	6	increased	increase	VBN
cord-337365-hugenn14	187	7	reports	report	NNS
cord-337365-hugenn14	187	8	of	of	IN
cord-337365-hugenn14	187	9	cases	case	NNS
cord-337365-hugenn14	187	10	of	of	IN
cord-337365-hugenn14	187	11	simultaneous	simultaneous	JJ
cord-337365-hugenn14	187	12	diagnosis	diagnosis	NN
cord-337365-hugenn14	187	13	of	of	IN
cord-337365-hugenn14	187	14	Guillain	Guillain	NNP
cord-337365-hugenn14	187	15	-	-	HYPH
cord-337365-hugenn14	187	16	Barré	Barré	NNP
cord-337365-hugenn14	187	17	syndrome	syndrome	NN
cord-337365-hugenn14	187	18	in	in	IN
cord-337365-hugenn14	187	19	adults	adult	NNS
cord-337365-hugenn14	187	20	with	with	IN
cord-337365-hugenn14	187	21	French	french	JJ
cord-337365-hugenn14	187	22	Polynesia	Polynesia	NNP
cord-337365-hugenn14	187	23	ZIKV	zikv	NN
cord-337365-hugenn14	187	24	infection	infection	NN
cord-337365-hugenn14	187	25	[	[	-LRB-
cord-337365-hugenn14	187	26	58	58	CD
cord-337365-hugenn14	187	27	]	]	-RRB-
cord-337365-hugenn14	187	28	.	.	.
cord-337365-hugenn14	188	1	Recent	recent	JJ
cord-337365-hugenn14	188	2	evidence	evidence	NN
cord-337365-hugenn14	188	3	suggests	suggest	VBZ
cord-337365-hugenn14	188	4	a	a	DT
cord-337365-hugenn14	188	5	causal	causal	JJ
cord-337365-hugenn14	188	6	relationship	relationship	NN
cord-337365-hugenn14	188	7	between	between	IN
cord-337365-hugenn14	188	8	prenatal	prenatal	JJ
cord-337365-hugenn14	188	9	ZIKV	zikv	NN
cord-337365-hugenn14	188	10	infection	infection	NN
cord-337365-hugenn14	188	11	and	and	CC
cord-337365-hugenn14	188	12	severe	severe	JJ
cord-337365-hugenn14	188	13	brain	brain	NN
cord-337365-hugenn14	188	14	abnormalities	abnormality	NNS
cord-337365-hugenn14	188	15	including	include	VBG
cord-337365-hugenn14	188	16	microcephaly	microcephaly	NNS
cord-337365-hugenn14	188	17	[	[	-LRB-
cord-337365-hugenn14	188	18	59	59	CD
cord-337365-hugenn14	188	19	]	]	-RRB-
cord-337365-hugenn14	188	20	.	.	.
cord-337365-hugenn14	189	1	ZIKV	ZIKV	NNP
cord-337365-hugenn14	189	2	was	be	VBD
cord-337365-hugenn14	189	3	detected	detect	VBN
cord-337365-hugenn14	189	4	in	in	IN
cord-337365-hugenn14	189	5	the	the	DT
cord-337365-hugenn14	189	6	brain	brain	NN
cord-337365-hugenn14	189	7	of	of	IN
cord-337365-hugenn14	189	8	a	a	DT
cord-337365-hugenn14	189	9	microcephalic	microcephalic	JJ
cord-337365-hugenn14	189	10	fetus	fetus	NN
cord-337365-hugenn14	189	11	[	[	-LRB-
cord-337365-hugenn14	189	12	60	60	CD
cord-337365-hugenn14	189	13	]	]	-RRB-
cord-337365-hugenn14	189	14	.	.	.
cord-337365-hugenn14	190	1	This	this	DT
cord-337365-hugenn14	190	2	means	mean	VBZ
cord-337365-hugenn14	190	3	that	that	IN
cord-337365-hugenn14	190	4	there	there	EX
cord-337365-hugenn14	190	5	is	be	VBZ
cord-337365-hugenn14	190	6	a	a	DT
cord-337365-hugenn14	190	7	strong	strong	JJ
cord-337365-hugenn14	190	8	connection	connection	NN
cord-337365-hugenn14	190	9	between	between	IN
cord-337365-hugenn14	190	10	ZIKV	ZIKV	NNP
cord-337365-hugenn14	190	11	and	and	CC
cord-337365-hugenn14	190	12	these	these	DT
cord-337365-hugenn14	190	13	neurological	neurological	JJ
cord-337365-hugenn14	190	14	diseases	disease	NNS
cord-337365-hugenn14	190	15	.	.	.
cord-337365-hugenn14	191	1	The	the	DT
cord-337365-hugenn14	191	2	study	study	NN
cord-337365-hugenn14	191	3	found	find	VBD
cord-337365-hugenn14	191	4	that	that	IN
cord-337365-hugenn14	191	5	ZIKV	ZIKV	NNP
cord-337365-hugenn14	191	6	mainly	mainly	RB
cord-337365-hugenn14	191	7	infects	infect	VBZ
cord-337365-hugenn14	191	8	fetal	fetal	JJ
cord-337365-hugenn14	191	9	microglia	microglia	NN
cord-337365-hugenn14	191	10	and	and	CC
cord-337365-hugenn14	191	11	induces	induce	VBZ
cord-337365-hugenn14	191	12	high	high	JJ
cord-337365-hugenn14	191	13	levels	level	NNS
cord-337365-hugenn14	191	14	of	of	IN
cord-337365-hugenn14	191	15	pro	pro	JJ
cord-337365-hugenn14	191	16	-	-	JJ
cord-337365-hugenn14	191	17	inflammatory	inflammatory	JJ
cord-337365-hugenn14	191	18	mediators	mediator	NNS
cord-337365-hugenn14	191	19	including	include	VBG
cord-337365-hugenn14	191	20	IL-6	IL-6	NNP
cord-337365-hugenn14	191	21	,	,	,
cord-337365-hugenn14	191	22	TNF	TNF	NNP
cord-337365-hugenn14	191	23	-	-	HYPH
cord-337365-hugenn14	191	24	α	α	NNP
cord-337365-hugenn14	191	25	,	,	,
cord-337365-hugenn14	191	26	IL-1β	IL-1β	NNP
cord-337365-hugenn14	191	27	,	,	,
cord-337365-hugenn14	191	28	and	and	CC
cord-337365-hugenn14	191	29	MCP-1	MCP-1	NNP
cord-337365-hugenn14	191	30	.	.	.
cord-337365-hugenn14	192	1	These	these	DT
cord-337365-hugenn14	192	2	inflammatory	inflammatory	JJ
cord-337365-hugenn14	192	3	factors	factor	NNS
cord-337365-hugenn14	192	4	may	may	MD
cord-337365-hugenn14	192	5	be	be	VB
cord-337365-hugenn14	192	6	harmful	harmful	JJ
cord-337365-hugenn14	192	7	to	to	IN
cord-337365-hugenn14	192	8	the	the	DT
cord-337365-hugenn14	192	9	fetus	fetus	NN
cord-337365-hugenn14	192	10	[	[	-LRB-
cord-337365-hugenn14	192	11	61	61	CD
cord-337365-hugenn14	192	12	]	]	-RRB-
cord-337365-hugenn14	192	13	.	.	.
cord-337365-hugenn14	193	1	Microglia	Microglia	NNP
cord-337365-hugenn14	193	2	's	's	POS
cord-337365-hugenn14	193	3	perivascular	perivascular	JJ
cord-337365-hugenn14	193	4	localization	localization	NN
cord-337365-hugenn14	193	5	enables	enable	VBZ
cord-337365-hugenn14	193	6	them	-PRON-	PRP
cord-337365-hugenn14	193	7	to	to	TO
cord-337365-hugenn14	193	8	survey	survey	VB
cord-337365-hugenn14	193	9	the	the	DT
cord-337365-hugenn14	193	10	influx	influx	NN
cord-337365-hugenn14	193	11	of	of	IN
cord-337365-hugenn14	193	12	blood	blood	NN
cord-337365-hugenn14	193	13	-	-	HYPH
cord-337365-hugenn14	193	14	borne	bear	VBN
cord-337365-hugenn14	193	15	components	component	NNS
cord-337365-hugenn14	193	16	into	into	IN
cord-337365-hugenn14	193	17	the	the	DT
cord-337365-hugenn14	193	18	CNS	CNS	NNP
cord-337365-hugenn14	193	19	[	[	-LRB-
cord-337365-hugenn14	193	20	62	62	CD
cord-337365-hugenn14	193	21	]	]	-RRB-
cord-337365-hugenn14	193	22	.	.	.
cord-337365-hugenn14	194	1	Thus	thus	RB
cord-337365-hugenn14	194	2	,	,	,
cord-337365-hugenn14	194	3	microglia	microglia	NNS
cord-337365-hugenn14	194	4	are	be	VBP
cord-337365-hugenn14	194	5	highly	highly	RB
cord-337365-hugenn14	194	6	susceptible	susceptible	JJ
cord-337365-hugenn14	194	7	to	to	IN
cord-337365-hugenn14	194	8	ZIKV	zikv	NN
cord-337365-hugenn14	194	9	infection	infection	NN
cord-337365-hugenn14	194	10	.	.	.
cord-337365-hugenn14	195	1	The	the	DT
cord-337365-hugenn14	195	2	analysis	analysis	NN
cord-337365-hugenn14	195	3	of	of	IN
cord-337365-hugenn14	195	4	vitro	vitro	FW
cord-337365-hugenn14	195	5	culture	culture	NN
cord-337365-hugenn14	195	6	and	and	CC
cord-337365-hugenn14	195	7	microcephalic	microcephalic	JJ
cord-337365-hugenn14	195	8	Fig	fig	NN
cord-337365-hugenn14	195	9	.	.	.
cord-337365-hugenn14	196	1	2	2	CD
cord-337365-hugenn14	196	2	Illustration	illustration	NN
cord-337365-hugenn14	196	3	of	of	IN
cord-337365-hugenn14	196	4	the	the	DT
cord-337365-hugenn14	196	5	pro	pro	JJ
cord-337365-hugenn14	196	6	-	-	JJ
cord-337365-hugenn14	196	7	inflammatory	inflammatory	JJ
cord-337365-hugenn14	196	8	role	role	NN
cord-337365-hugenn14	196	9	of	of	IN
cord-337365-hugenn14	196	10	microglia	microglia	NN
cord-337365-hugenn14	196	11	in	in	IN
cord-337365-hugenn14	196	12	viral	viral	JJ
cord-337365-hugenn14	196	13	encephalitis	encephalitis	RB
cord-337365-hugenn14	196	14	.	.	.
cord-337365-hugenn14	197	1	The	the	DT
cord-337365-hugenn14	197	2	picture	picture	NN
cord-337365-hugenn14	197	3	shows	show	VBZ
cord-337365-hugenn14	197	4	some	some	DT
cord-337365-hugenn14	197	5	harmful	harmful	JJ
cord-337365-hugenn14	197	6	effects	effect	NNS
cord-337365-hugenn14	197	7	of	of	IN
cord-337365-hugenn14	197	8	microglia	microglia	NNS
cord-337365-hugenn14	197	9	in	in	IN
cord-337365-hugenn14	197	10	viral	viral	JJ
cord-337365-hugenn14	197	11	encephalitis	encephalitis	RB
cord-337365-hugenn14	197	12	,	,	,
cord-337365-hugenn14	197	13	such	such	JJ
cord-337365-hugenn14	197	14	as	as	IN
cord-337365-hugenn14	197	15	mediating	mediate	VBG
cord-337365-hugenn14	197	16	presynaptic	presynaptic	JJ
cord-337365-hugenn14	197	17	membrane	membrane	NN
cord-337365-hugenn14	197	18	damage	damage	NN
cord-337365-hugenn14	197	19	,	,	,
cord-337365-hugenn14	197	20	causing	cause	VBG
cord-337365-hugenn14	197	21	fetal	fetal	JJ
cord-337365-hugenn14	197	22	congenital	congenital	JJ
cord-337365-hugenn14	197	23	malformations	malformation	NNS
cord-337365-hugenn14	197	24	,	,	,
cord-337365-hugenn14	197	25	and	and	CC
cord-337365-hugenn14	197	26	exacerbating	exacerbate	VBG
cord-337365-hugenn14	197	27	the	the	DT
cord-337365-hugenn14	197	28	damage	damage	NN
cord-337365-hugenn14	197	29	of	of	IN
cord-337365-hugenn14	197	30	CNS	CNS	NNP
cord-337365-hugenn14	197	31	in	in	IN
cord-337365-hugenn14	197	32	HIV	HIV	NNP
cord-337365-hugenn14	197	33	encephalitis	encephalitis	RB
cord-337365-hugenn14	197	34	.	.	.
cord-337365-hugenn14	198	1	Microglia	Microglia	NNP
cord-337365-hugenn14	198	2	play	play	VBP
cord-337365-hugenn14	198	3	an	an	DT
cord-337365-hugenn14	198	4	uncertain	uncertain	JJ
cord-337365-hugenn14	198	5	role	role	NN
cord-337365-hugenn14	198	6	in	in	IN
cord-337365-hugenn14	198	7	virus	virus	NN
cord-337365-hugenn14	198	8	-	-	HYPH
cord-337365-hugenn14	198	9	induced	induce	VBN
cord-337365-hugenn14	198	10	Aβ	Aβ	NNP
cord-337365-hugenn14	198	11	.	.	.
cord-337365-hugenn14	199	1	The	the	DT
cord-337365-hugenn14	199	2	role	role	NN
cord-337365-hugenn14	199	3	of	of	IN
cord-337365-hugenn14	199	4	the	the	DT
cord-337365-hugenn14	199	5	RIPK3	ripk3	NN
cord-337365-hugenn14	199	6	signaling	signal	VBG
cord-337365-hugenn14	199	7	pathway	pathway	NN
cord-337365-hugenn14	199	8	in	in	IN
cord-337365-hugenn14	199	9	microglia	microglia	NNS
cord-337365-hugenn14	199	10	in	in	IN
cord-337365-hugenn14	199	11	viral	viral	JJ
cord-337365-hugenn14	199	12	encephalitis	encephalitis	NN
cord-337365-hugenn14	199	13	remains	remain	VBZ
cord-337365-hugenn14	199	14	obscure	obscure	JJ
cord-337365-hugenn14	199	15	fetal	fetal	JJ
cord-337365-hugenn14	199	16	brain	brain	NN
cord-337365-hugenn14	199	17	histology	histology	NN
cord-337365-hugenn14	199	18	showed	show	VBD
cord-337365-hugenn14	199	19	that	that	IN
cord-337365-hugenn14	199	20	ZIKV	ZIKV	NNP
cord-337365-hugenn14	199	21	leads	lead	VBZ
cord-337365-hugenn14	199	22	to	to	IN
cord-337365-hugenn14	199	23	activation	activation	NN
cord-337365-hugenn14	199	24	of	of	IN
cord-337365-hugenn14	199	25	microglia	microglia	NNP
cord-337365-hugenn14	199	26	[	[	-LRB-
cord-337365-hugenn14	199	27	60	60	CD
cord-337365-hugenn14	199	28	]	]	-RRB-
cord-337365-hugenn14	199	29	.	.	.
cord-337365-hugenn14	200	1	This	this	DT
cord-337365-hugenn14	200	2	,	,	,
cord-337365-hugenn14	200	3	in	in	IN
cord-337365-hugenn14	200	4	turn	turn	NN
cord-337365-hugenn14	200	5	,	,	,
cord-337365-hugenn14	200	6	causes	cause	VBZ
cord-337365-hugenn14	200	7	localized	localize	VBN
cord-337365-hugenn14	200	8	neuroinflammation	neuroinflammation	NN
cord-337365-hugenn14	200	9	and	and	CC
cord-337365-hugenn14	200	10	is	be	VBZ
cord-337365-hugenn14	200	11	accompanied	accompany	VBN
cord-337365-hugenn14	200	12	by	by	IN
cord-337365-hugenn14	200	13	viral	viral	JJ
cord-337365-hugenn14	200	14	disseminating	disseminating	NN
cord-337365-hugenn14	200	15	to	to	IN
cord-337365-hugenn14	200	16	the	the	DT
cord-337365-hugenn14	200	17	brain	brain	NN
cord-337365-hugenn14	200	18	parenchyma	parenchyma	NN
cord-337365-hugenn14	200	19	,	,	,
cord-337365-hugenn14	200	20	which	which	WDT
cord-337365-hugenn14	200	21	may	may	MD
cord-337365-hugenn14	200	22	lead	lead	VB
cord-337365-hugenn14	200	23	to	to	IN
cord-337365-hugenn14	200	24	the	the	DT
cord-337365-hugenn14	200	25	development	development	NN
cord-337365-hugenn14	200	26	of	of	IN
cord-337365-hugenn14	200	27	neuronal	neuronal	JJ
cord-337365-hugenn14	200	28	death	death	NN
cord-337365-hugenn14	200	29	,	,	,
cord-337365-hugenn14	200	30	especially	especially	RB
cord-337365-hugenn14	200	31	in	in	IN
cord-337365-hugenn14	200	32	the	the	DT
cord-337365-hugenn14	200	33	cerebral	cerebral	JJ
cord-337365-hugenn14	200	34	cortex	cortex	NN
cord-337365-hugenn14	200	35	,	,	,
cord-337365-hugenn14	200	36	causing	cause	VBG
cord-337365-hugenn14	200	37	neurological	neurological	JJ
cord-337365-hugenn14	200	38	changes	change	NNS
cord-337365-hugenn14	200	39	and	and	CC
cord-337365-hugenn14	200	40	microcephaly	microcephaly	NNS
cord-337365-hugenn14	200	41	.	.	.
cord-337365-hugenn14	201	1	These	these	DT
cord-337365-hugenn14	201	2	findings	finding	NNS
cord-337365-hugenn14	201	3	reveal	reveal	VBP
cord-337365-hugenn14	201	4	that	that	IN
cord-337365-hugenn14	201	5	microglia	microglia	NNS
cord-337365-hugenn14	201	6	play	play	VBP
cord-337365-hugenn14	201	7	an	an	DT
cord-337365-hugenn14	201	8	important	important	JJ
cord-337365-hugenn14	201	9	role	role	NN
cord-337365-hugenn14	201	10	in	in	IN
cord-337365-hugenn14	201	11	the	the	DT
cord-337365-hugenn14	201	12	pathogenesis	pathogenesis	NN
cord-337365-hugenn14	201	13	of	of	IN
cord-337365-hugenn14	201	14	congenital	congenital	JJ
cord-337365-hugenn14	201	15	ZIKV	zikv	NN
cord-337365-hugenn14	201	16	infection	infection	NN
cord-337365-hugenn14	201	17	[	[	-LRB-
cord-337365-hugenn14	201	18	61	61	CD
cord-337365-hugenn14	201	19	]	]	-RRB-
cord-337365-hugenn14	201	20	.	.	.
cord-337365-hugenn14	202	1	Microglia	Microglia	NNP
cord-337365-hugenn14	202	2	are	be	VBP
cord-337365-hugenn14	202	3	the	the	DT
cord-337365-hugenn14	202	4	main	main	JJ
cord-337365-hugenn14	202	5	target	target	NN
cord-337365-hugenn14	202	6	of	of	IN
cord-337365-hugenn14	202	7	HIV-1	HIV-1	NNP
cord-337365-hugenn14	202	8	infection	infection	NN
cord-337365-hugenn14	202	9	in	in	IN
cord-337365-hugenn14	202	10	the	the	DT
cord-337365-hugenn14	202	11	brain	brain	NN
cord-337365-hugenn14	202	12	[	[	-LRB-
cord-337365-hugenn14	202	13	63	63	CD
cord-337365-hugenn14	202	14	]	]	-RRB-
cord-337365-hugenn14	202	15	.	.	.
cord-337365-hugenn14	203	1	There	there	EX
cord-337365-hugenn14	203	2	are	be	VBP
cord-337365-hugenn14	203	3	viral	viral	JJ
cord-337365-hugenn14	203	4	particles	particle	NNS
cord-337365-hugenn14	203	5	in	in	IN
cord-337365-hugenn14	203	6	the	the	DT
cord-337365-hugenn14	203	7	infected	infected	JJ
cord-337365-hugenn14	203	8	microglia	microglia	NN
cord-337365-hugenn14	203	9	,	,	,
cord-337365-hugenn14	203	10	suggesting	suggest	VBG
cord-337365-hugenn14	203	11	that	that	IN
cord-337365-hugenn14	203	12	they	-PRON-	PRP
cord-337365-hugenn14	203	13	may	may	MD
cord-337365-hugenn14	203	14	be	be	VB
cord-337365-hugenn14	203	15	a	a	DT
cord-337365-hugenn14	203	16	potential	potential	JJ
cord-337365-hugenn14	203	17	virus	virus	NN
cord-337365-hugenn14	203	18	reservoir	reservoir	NN
cord-337365-hugenn14	203	19	[	[	-LRB-
cord-337365-hugenn14	203	20	64	64	CD
cord-337365-hugenn14	203	21	]	]	-RRB-
cord-337365-hugenn14	203	22	.	.	.
cord-337365-hugenn14	204	1	The	the	DT
cord-337365-hugenn14	204	2	main	main	JJ
cord-337365-hugenn14	204	3	features	feature	NNS
cord-337365-hugenn14	204	4	of	of	IN
cord-337365-hugenn14	204	5	HIV-1	HIV-1	NNP
cord-337365-hugenn14	204	6	encephalitis	encephalitis	RB
cord-337365-hugenn14	204	7	are	be	VBP
cord-337365-hugenn14	204	8	the	the	DT
cord-337365-hugenn14	204	9	formation	formation	NN
cord-337365-hugenn14	204	10	of	of	IN
cord-337365-hugenn14	204	11	multinucleated	multinucleated	JJ
cord-337365-hugenn14	204	12	giant	giant	JJ
cord-337365-hugenn14	204	13	cells	cell	NNS
cord-337365-hugenn14	204	14	,	,	,
cord-337365-hugenn14	204	15	microglia	microglia	JJ
cord-337365-hugenn14	204	16	nodules	nodule	NNS
cord-337365-hugenn14	204	17	,	,	,
cord-337365-hugenn14	204	18	and	and	CC
cord-337365-hugenn14	204	19	macrophage	macrophage	NN
cord-337365-hugenn14	204	20	infiltration	infiltration	NN
cord-337365-hugenn14	204	21	into	into	IN
cord-337365-hugenn14	204	22	the	the	DT
cord-337365-hugenn14	204	23	central	central	JJ
cord-337365-hugenn14	204	24	nervous	nervous	JJ
cord-337365-hugenn14	204	25	system	system	NN
cord-337365-hugenn14	204	26	[	[	-LRB-
cord-337365-hugenn14	204	27	65	65	CD
cord-337365-hugenn14	204	28	]	]	-RRB-
cord-337365-hugenn14	204	29	.	.	.
cord-337365-hugenn14	205	1	The	the	DT
cord-337365-hugenn14	205	2	formation	formation	NN
cord-337365-hugenn14	205	3	of	of	IN
cord-337365-hugenn14	205	4	multinucleated	multinucleated	JJ
cord-337365-hugenn14	205	5	giant	giant	JJ
cord-337365-hugenn14	205	6	cells	cell	NNS
cord-337365-hugenn14	205	7	reflects	reflect	VBZ
cord-337365-hugenn14	205	8	the	the	DT
cord-337365-hugenn14	205	9	infection	infection	NN
cord-337365-hugenn14	205	10	of	of	IN
cord-337365-hugenn14	205	11	HIV-1	HIV-1	NNP
cord-337365-hugenn14	205	12	microglia	microglia	NNS
cord-337365-hugenn14	205	13	in	in	IN
cord-337365-hugenn14	205	14	vitro	vitro	FW
cord-337365-hugenn14	205	15	.	.	.
cord-337365-hugenn14	206	1	Active	active	JJ
cord-337365-hugenn14	206	2	infection	infection	NN
cord-337365-hugenn14	206	3	of	of	IN
cord-337365-hugenn14	206	4	microglia	microglia	NN
cord-337365-hugenn14	206	5	is	be	VBZ
cord-337365-hugenn14	206	6	ultimately	ultimately	RB
cord-337365-hugenn14	206	7	associated	associate	VBN
cord-337365-hugenn14	206	8	with	with	IN
cord-337365-hugenn14	206	9	astrogliosis	astrogliosis	NN
cord-337365-hugenn14	206	10	,	,	,
cord-337365-hugenn14	206	11	myelin	myelin	NN
cord-337365-hugenn14	206	12	pallor	pallor	NN
cord-337365-hugenn14	206	13	,	,	,
cord-337365-hugenn14	206	14	and	and	CC
cord-337365-hugenn14	206	15	neuronal	neuronal	JJ
cord-337365-hugenn14	206	16	loss	loss	NN
cord-337365-hugenn14	206	17	[	[	-LRB-
cord-337365-hugenn14	206	18	65	65	CD
cord-337365-hugenn14	206	19	]	]	-RRB-
cord-337365-hugenn14	206	20	.	.	.
cord-337365-hugenn14	207	1	Although	although	IN
cord-337365-hugenn14	207	2	there	there	EX
cord-337365-hugenn14	207	3	are	be	VBP
cord-337365-hugenn14	207	4	ample	ample	JJ
cord-337365-hugenn14	207	5	evidences	evidence	NNS
cord-337365-hugenn14	207	6	confirming	confirm	VBG
cord-337365-hugenn14	207	7	that	that	IN
cord-337365-hugenn14	207	8	activated	activate	VBN
cord-337365-hugenn14	207	9	microglia	microglia	NNS
cord-337365-hugenn14	207	10	have	have	VBP
cord-337365-hugenn14	207	11	neuropathic	neuropathic	JJ
cord-337365-hugenn14	207	12	effects	effect	NNS
cord-337365-hugenn14	207	13	in	in	IN
cord-337365-hugenn14	207	14	HIV-1	HIV-1	NNP
cord-337365-hugenn14	207	15	encephalitis	encephalitis	RB
cord-337365-hugenn14	207	16	,	,	,
cord-337365-hugenn14	207	17	there	there	EX
cord-337365-hugenn14	207	18	are	be	VBP
cord-337365-hugenn14	207	19	data	datum	NNS
cord-337365-hugenn14	207	20	suggesting	suggest	VBG
cord-337365-hugenn14	207	21	that	that	IN
cord-337365-hugenn14	207	22	microglia	microglia	NNP
cord-337365-hugenn14	207	23	may	may	MD
cord-337365-hugenn14	207	24	have	have	VB
cord-337365-hugenn14	207	25	some	some	DT
cord-337365-hugenn14	207	26	neuroprotective	neuroprotective	JJ
cord-337365-hugenn14	207	27	effects	effect	NNS
cord-337365-hugenn14	207	28	in	in	IN
cord-337365-hugenn14	207	29	the	the	DT
cord-337365-hugenn14	207	30	early	early	JJ
cord-337365-hugenn14	207	31	stages	stage	NNS
cord-337365-hugenn14	207	32	of	of	IN
cord-337365-hugenn14	207	33	HIV	HIV	NNP
cord-337365-hugenn14	207	34	disease	disease	NN
cord-337365-hugenn14	207	35	[	[	-LRB-
cord-337365-hugenn14	207	36	66	66	CD
cord-337365-hugenn14	207	37	]	]	-RRB-
cord-337365-hugenn14	207	38	.	.	.
cord-337365-hugenn14	208	1	Molecular	molecular	JJ
cord-337365-hugenn14	208	2	and	and	CC
cord-337365-hugenn14	208	3	histopathology	histopathology	NN
cord-337365-hugenn14	208	4	confirm	confirm	VBP
cord-337365-hugenn14	208	5	the	the	DT
cord-337365-hugenn14	208	6	reduction	reduction	NN
cord-337365-hugenn14	208	7	of	of	IN
cord-337365-hugenn14	208	8	autophagy	autophagy	NN
cord-337365-hugenn14	208	9	in	in	IN
cord-337365-hugenn14	208	10	the	the	DT
cord-337365-hugenn14	208	11	brain	brain	NN
cord-337365-hugenn14	208	12	of	of	IN
cord-337365-hugenn14	208	13	patients	patient	NNS
cord-337365-hugenn14	208	14	with	with	IN
cord-337365-hugenn14	208	15	HIV	HIV	NNP
cord-337365-hugenn14	208	16	-	-	HYPH
cord-337365-hugenn14	208	17	associated	associate	VBN
cord-337365-hugenn14	208	18	dementia	dementia	NN
cord-337365-hugenn14	208	19	.	.	.
cord-337365-hugenn14	209	1	HIV-1-infected	hiv-1-infecte	VBN
cord-337365-hugenn14	209	2	microglia	microglia	NN
cord-337365-hugenn14	209	3	release	release	NN
cord-337365-hugenn14	209	4	neurotoxins	neurotoxin	NNS
cord-337365-hugenn14	209	5	,	,	,
cord-337365-hugenn14	209	6	cytokines	cytokine	NNS
cord-337365-hugenn14	209	7	,	,	,
cord-337365-hugenn14	209	8	viral	viral	JJ
cord-337365-hugenn14	209	9	proteins	protein	NNS
cord-337365-hugenn14	209	10	,	,	,
cord-337365-hugenn14	209	11	and	and	CC
cord-337365-hugenn14	209	12	glutamate	glutamate	NN
cord-337365-hugenn14	209	13	;	;	:
cord-337365-hugenn14	209	14	activate	activate	VB
cord-337365-hugenn14	209	15	NMDA	NMDA	NNP
cord-337365-hugenn14	209	16	receptors	receptor	NNS
cord-337365-hugenn14	209	17	on	on	IN
cord-337365-hugenn14	209	18	neurons	neuron	NNS
cord-337365-hugenn14	209	19	;	;	:
cord-337365-hugenn14	209	20	cause	cause	VB
cord-337365-hugenn14	209	21	calcium	calcium	NN
cord-337365-hugenn14	209	22	influx	influx	NN
cord-337365-hugenn14	209	23	,	,	,
cord-337365-hugenn14	209	24	inhibit	inhibit	VB
cord-337365-hugenn14	209	25	neuronal	neuronal	JJ
cord-337365-hugenn14	209	26	autophagy	autophagy	NN
cord-337365-hugenn14	209	27	;	;	:
cord-337365-hugenn14	209	28	enhance	enhance	VB
cord-337365-hugenn14	209	29	apoptotic	apoptotic	JJ
cord-337365-hugenn14	209	30	pathways	pathway	NNS
cord-337365-hugenn14	209	31	;	;	:
cord-337365-hugenn14	209	32	and	and	CC
cord-337365-hugenn14	209	33	ultimately	ultimately	RB
cord-337365-hugenn14	209	34	lead	lead	VBP
cord-337365-hugenn14	209	35	to	to	IN
cord-337365-hugenn14	209	36	neuronal	neuronal	JJ
cord-337365-hugenn14	209	37	death	death	NN
cord-337365-hugenn14	209	38	[	[	-LRB-
cord-337365-hugenn14	209	39	67	67	CD
cord-337365-hugenn14	209	40	]	]	-RRB-
cord-337365-hugenn14	209	41	.	.	.
cord-337365-hugenn14	210	1	Enhancing	enhance	VBG
cord-337365-hugenn14	210	2	autophagy	autophagy	NN
cord-337365-hugenn14	210	3	of	of	IN
cord-337365-hugenn14	210	4	neurons	neuron	NNS
cord-337365-hugenn14	210	5	in	in	IN
cord-337365-hugenn14	210	6	patients	patient	NNS
cord-337365-hugenn14	210	7	with	with	IN
cord-337365-hugenn14	210	8	HIV	HIV	NNP
cord-337365-hugenn14	210	9	encephalitis	encephalitis	RB
cord-337365-hugenn14	210	10	may	may	MD
cord-337365-hugenn14	210	11	become	become	VB
cord-337365-hugenn14	210	12	a	a	DT
cord-337365-hugenn14	210	13	target	target	NN
cord-337365-hugenn14	210	14	for	for	IN
cord-337365-hugenn14	210	15	future	future	JJ
cord-337365-hugenn14	210	16	treatment	treatment	NN
cord-337365-hugenn14	210	17	.	.	.
cord-337365-hugenn14	211	1	Microarray	Microarray	NNP
cord-337365-hugenn14	211	2	analyses	analysis	NNS
cord-337365-hugenn14	211	3	were	be	VBD
cord-337365-hugenn14	211	4	performed	perform	VBN
cord-337365-hugenn14	211	5	using	use	VBG
cord-337365-hugenn14	211	6	brain	brain	NN
cord-337365-hugenn14	211	7	tissue	tissue	NN
cord-337365-hugenn14	211	8	samples	sample	NNS
cord-337365-hugenn14	211	9	from	from	IN
cord-337365-hugenn14	211	10	HIV	HIV	NNP
cord-337365-hugenn14	211	11	encephalitis	encephalitis	NNP
cord-337365-hugenn14	211	12	(	(	-LRB-
cord-337365-hugenn14	211	13	HIVE	HIVE	NNP
cord-337365-hugenn14	211	14	)	)	-RRB-
cord-337365-hugenn14	211	15	patients	patient	NNS
cord-337365-hugenn14	211	16	,	,	,
cord-337365-hugenn14	211	17	HIV+	HIV+	NNP
cord-337365-hugenn14	211	18	patients	patient	NNS
cord-337365-hugenn14	211	19	without	without	IN
cord-337365-hugenn14	211	20	encephalitis	encephalitis	JJ
cord-337365-hugenn14	211	21	(	(	-LRB-
cord-337365-hugenn14	211	22	HIV	HIV	NNP
cord-337365-hugenn14	211	23	/	/	SYM
cord-337365-hugenn14	211	24	noE	noE	NNP
cord-337365-hugenn14	211	25	)	)	-RRB-
cord-337365-hugenn14	211	26	,	,	,
cord-337365-hugenn14	211	27	and	and	CC
cord-337365-hugenn14	211	28	HIV−	hiv−	DT
cord-337365-hugenn14	211	29	controls	control	VBZ
cord-337365-hugenn14	211	30	.	.	.
cord-337365-hugenn14	212	1	It	-PRON-	PRP
cord-337365-hugenn14	212	2	was	be	VBD
cord-337365-hugenn14	212	3	found	find	VBN
cord-337365-hugenn14	212	4	that	that	IN
cord-337365-hugenn14	212	5	a	a	DT
cord-337365-hugenn14	212	6	large	large	JJ
cord-337365-hugenn14	212	7	number	number	NN
cord-337365-hugenn14	212	8	of	of	IN
cord-337365-hugenn14	212	9	microglia	microglia	JJ
cord-337365-hugenn14	212	10	genes	gene	NNS
cord-337365-hugenn14	212	11	have	have	VBP
cord-337365-hugenn14	212	12	undergone	undergo	VBN
cord-337365-hugenn14	212	13	significant	significant	JJ
cord-337365-hugenn14	212	14	changes	change	NNS
cord-337365-hugenn14	212	15	during	during	IN
cord-337365-hugenn14	212	16	HIV	HIV	NNP
cord-337365-hugenn14	212	17	infection	infection	NN
cord-337365-hugenn14	212	18	,	,	,
cord-337365-hugenn14	212	19	including	include	VBG
cord-337365-hugenn14	212	20	immune	immune	JJ
cord-337365-hugenn14	212	21	activation	activation	NN
cord-337365-hugenn14	212	22	and	and	CC
cord-337365-hugenn14	212	23	function	function	NN
cord-337365-hugenn14	212	24	,	,	,
cord-337365-hugenn14	212	25	kinases	kinase	NNS
cord-337365-hugenn14	212	26	,	,	,
cord-337365-hugenn14	212	27	phosphatases	phosphatase	NNS
cord-337365-hugenn14	212	28	,	,	,
cord-337365-hugenn14	212	29	and	and	CC
cord-337365-hugenn14	212	30	pro-/anti	pro-/anti	JJ
cord-337365-hugenn14	212	31	-	-	HYPH
cord-337365-hugenn14	212	32	apoptotic	apoptotic	JJ
cord-337365-hugenn14	212	33	and	and	CC
cord-337365-hugenn14	212	34	neurotrophic	neurotrophic	NN
cord-337365-hugenn14	212	35	factors	factor	NNS
cord-337365-hugenn14	212	36	,	,	,
cord-337365-hugenn14	212	37	indicating	indicate	VBG
cord-337365-hugenn14	212	38	that	that	IN
cord-337365-hugenn14	212	39	the	the	DT
cord-337365-hugenn14	212	40	microglia	microglia	NN
cord-337365-hugenn14	212	41	function	function	NN
cord-337365-hugenn14	212	42	is	be	VBZ
cord-337365-hugenn14	212	43	impaired	impair	VBN
cord-337365-hugenn14	212	44	and	and	CC
cord-337365-hugenn14	212	45	has	have	VBZ
cord-337365-hugenn14	212	46	a	a	DT
cord-337365-hugenn14	212	47	pro	pro	JJ
cord-337365-hugenn14	212	48	-	-	JJ
cord-337365-hugenn14	212	49	inflammatory	inflammatory	JJ
cord-337365-hugenn14	212	50	tendency	tendency	NN
cord-337365-hugenn14	212	51	[	[	-LRB-
cord-337365-hugenn14	212	52	68	68	CD
cord-337365-hugenn14	212	53	]	]	-RRB-
cord-337365-hugenn14	212	54	.	.	.
cord-337365-hugenn14	213	1	Human	human	JJ
cord-337365-hugenn14	213	2	cytomegalovirus	cytomegalovirus	NN
cord-337365-hugenn14	213	3	(	(	-LRB-
cord-337365-hugenn14	213	4	HCMV	HCMV	NNP
cord-337365-hugenn14	213	5	)	)	-RRB-
cord-337365-hugenn14	213	6	can	can	MD
cord-337365-hugenn14	213	7	cause	cause	VB
cord-337365-hugenn14	213	8	congenital	congenital	JJ
cord-337365-hugenn14	213	9	encephalitis	encephalitis	RB
cord-337365-hugenn14	213	10	or	or	CC
cord-337365-hugenn14	213	11	cause	cause	VB
cord-337365-hugenn14	213	12	encephalitis	encephalitis	JJ
cord-337365-hugenn14	213	13	in	in	IN
cord-337365-hugenn14	213	14	AIDS	AIDS	NNP
cord-337365-hugenn14	213	15	patients	patient	NNS
cord-337365-hugenn14	213	16	[	[	-LRB-
cord-337365-hugenn14	213	17	69	69	CD
cord-337365-hugenn14	213	18	]	]	-RRB-
cord-337365-hugenn14	213	19	.	.	.
cord-337365-hugenn14	214	1	In	in	IN
cord-337365-hugenn14	214	2	patients	patient	NNS
cord-337365-hugenn14	214	3	with	with	IN
cord-337365-hugenn14	214	4	advanced	advanced	JJ
cord-337365-hugenn14	214	5	AIDS	AIDS	NNP
cord-337365-hugenn14	214	6	,	,	,
cord-337365-hugenn14	214	7	HCMV	HCMV	NNP
cord-337365-hugenn14	214	8	-	-	HYPH
cord-337365-hugenn14	214	9	induced	induce	VBN
cord-337365-hugenn14	214	10	central	central	JJ
cord-337365-hugenn14	214	11	nervous	nervous	JJ
cord-337365-hugenn14	214	12	system	system	NN
cord-337365-hugenn14	214	13	infection	infection	NN
cord-337365-hugenn14	214	14	leads	lead	VBZ
cord-337365-hugenn14	214	15	to	to	IN
cord-337365-hugenn14	214	16	two	two	CD
cord-337365-hugenn14	214	17	different	different	JJ
cord-337365-hugenn14	214	18	neuropathological	neuropathological	JJ
cord-337365-hugenn14	214	19	patterns	pattern	NNS
cord-337365-hugenn14	214	20	:	:	:
cord-337365-hugenn14	214	21	microglial	microglial	JJ
cord-337365-hugenn14	214	22	nodular	nodular	JJ
cord-337365-hugenn14	214	23	encephalitis	encephalitis	NNP
cord-337365-hugenn14	214	24	(	(	-LRB-
cord-337365-hugenn14	214	25	MGNE	MGNE	NNP
cord-337365-hugenn14	214	26	)	)	-RRB-
cord-337365-hugenn14	214	27	and	and	CC
cord-337365-hugenn14	214	28	ventriculoencephalitis	ventriculoencephalitis	NNP
cord-337365-hugenn14	214	29	(	(	-LRB-
cord-337365-hugenn14	214	30	VE	VE	NNP
cord-337365-hugenn14	214	31	)	)	-RRB-
cord-337365-hugenn14	214	32	.	.	.
cord-337365-hugenn14	215	1	Microglial	microglial	JJ
cord-337365-hugenn14	215	2	nodular	nodular	JJ
cord-337365-hugenn14	215	3	encephalitis	encephalitis	RB
cord-337365-hugenn14	215	4	consists	consist	VBZ
cord-337365-hugenn14	215	5	of	of	IN
cord-337365-hugenn14	215	6	diffuse	diffuse	JJ
cord-337365-hugenn14	215	7	microglial	microglial	JJ
cord-337365-hugenn14	215	8	cells	cell	NNS
cord-337365-hugenn14	215	9	,	,	,
cord-337365-hugenn14	215	10	aggregated	aggregate	VBN
cord-337365-hugenn14	215	11	astrocytes	astrocyte	NNS
cord-337365-hugenn14	215	12	,	,	,
cord-337365-hugenn14	215	13	and	and	CC
cord-337365-hugenn14	215	14	giant	giant	JJ
cord-337365-hugenn14	215	15	cells	cell	NNS
cord-337365-hugenn14	215	16	.	.	.
cord-337365-hugenn14	216	1	The	the	DT
cord-337365-hugenn14	216	2	formation	formation	NN
cord-337365-hugenn14	216	3	of	of	IN
cord-337365-hugenn14	216	4	microglial	microglial	JJ
cord-337365-hugenn14	216	5	nodules	nodule	NNS
cord-337365-hugenn14	216	6	is	be	VBZ
cord-337365-hugenn14	216	7	considered	consider	VBN
cord-337365-hugenn14	216	8	to	to	TO
cord-337365-hugenn14	216	9	be	be	VB
cord-337365-hugenn14	216	10	an	an	DT
cord-337365-hugenn14	216	11	important	important	JJ
cord-337365-hugenn14	216	12	cause	cause	NN
cord-337365-hugenn14	216	13	of	of	IN
cord-337365-hugenn14	216	14	HCMV	hcmv	NN
cord-337365-hugenn14	216	15	-	-	HYPH
cord-337365-hugenn14	216	16	related	relate	VBN
cord-337365-hugenn14	216	17	dementia	dementia	NN
cord-337365-hugenn14	216	18	in	in	IN
cord-337365-hugenn14	216	19	AIDS	AIDS	NNP
cord-337365-hugenn14	216	20	patients	patient	NNS
cord-337365-hugenn14	216	21	[	[	-LRB-
cord-337365-hugenn14	216	22	70	70	CD
cord-337365-hugenn14	216	23	]	]	-RRB-
cord-337365-hugenn14	216	24	.	.	.
cord-337365-hugenn14	217	1	Recently	recently	RB
cord-337365-hugenn14	217	2	,	,	,
cord-337365-hugenn14	217	3	a	a	DT
cord-337365-hugenn14	217	4	study	study	NN
cord-337365-hugenn14	217	5	hypothesized	hypothesize	VBD
cord-337365-hugenn14	217	6	that	that	IN
cord-337365-hugenn14	217	7	,	,	,
cord-337365-hugenn14	217	8	in	in	IN
cord-337365-hugenn14	217	9	Rasmussen	Rasmussen	NNP
cord-337365-hugenn14	217	10	encephalitis	encephalitis	JJ
cord-337365-hugenn14	217	11	(	(	-LRB-
cord-337365-hugenn14	217	12	RE	RE	NNP
cord-337365-hugenn14	217	13	)	)	-RRB-
cord-337365-hugenn14	217	14	,	,	,
cord-337365-hugenn14	217	15	microglial	microglial	JJ
cord-337365-hugenn14	217	16	nodules	nodule	NNS
cord-337365-hugenn14	217	17	with	with	IN
cord-337365-hugenn14	217	18	an	an	DT
cord-337365-hugenn14	217	19	upregulation	upregulation	NN
cord-337365-hugenn14	217	20	of	of	IN
cord-337365-hugenn14	217	21	TLRs	tlr	NNS
cord-337365-hugenn14	217	22	provide	provide	VBP
cord-337365-hugenn14	217	23	an	an	DT
cord-337365-hugenn14	217	24	environment	environment	NN
cord-337365-hugenn14	217	25	for	for	IN
cord-337365-hugenn14	217	26	the	the	DT
cord-337365-hugenn14	217	27	initiation	initiation	NN
cord-337365-hugenn14	217	28	of	of	IN
cord-337365-hugenn14	217	29	the	the	DT
cord-337365-hugenn14	217	30	later	later	RB
cord-337365-hugenn14	217	31	dominating	dominate	VBG
cord-337365-hugenn14	217	32	T	t	NN
cord-337365-hugenn14	217	33	cell	cell	NN
cord-337365-hugenn14	217	34	cytotoxicity	cytotoxicity	NN
cord-337365-hugenn14	217	35	.	.	.
cord-337365-hugenn14	218	1	However	however	RB
cord-337365-hugenn14	218	2	,	,	,
cord-337365-hugenn14	218	3	in	in	IN
cord-337365-hugenn14	218	4	the	the	DT
cord-337365-hugenn14	218	5	early	early	JJ
cord-337365-hugenn14	218	6	stages	stage	NNS
cord-337365-hugenn14	218	7	of	of	IN
cord-337365-hugenn14	218	8	viral	viral	JJ
cord-337365-hugenn14	218	9	encephalitis	encephalitis	RB
cord-337365-hugenn14	218	10	,	,	,
cord-337365-hugenn14	218	11	the	the	DT
cord-337365-hugenn14	218	12	interaction	interaction	NN
cord-337365-hugenn14	218	13	between	between	IN
cord-337365-hugenn14	218	14	microglial	microglial	JJ
cord-337365-hugenn14	218	15	nodules	nodule	NNS
cord-337365-hugenn14	218	16	and	and	CC
cord-337365-hugenn14	218	17	pathogenic	pathogenic	JJ
cord-337365-hugenn14	218	18	T	t	NN
cord-337365-hugenn14	218	19	cells	cell	NNS
cord-337365-hugenn14	218	20	remains	remain	VBZ
cord-337365-hugenn14	218	21	unclear	unclear	JJ
cord-337365-hugenn14	218	22	[	[	-LRB-
cord-337365-hugenn14	218	23	71	71	CD
cord-337365-hugenn14	218	24	]	]	-RRB-
cord-337365-hugenn14	218	25	.	.	.
cord-337365-hugenn14	219	1	In	in	IN
cord-337365-hugenn14	219	2	the	the	DT
cord-337365-hugenn14	219	3	brain	brain	NN
cord-337365-hugenn14	219	4	,	,	,
cord-337365-hugenn14	219	5	Peli1	peli1	NN
cord-337365-hugenn14	219	6	is	be	VBZ
cord-337365-hugenn14	219	7	mainly	mainly	RB
cord-337365-hugenn14	219	8	expressed	express	VBN
cord-337365-hugenn14	219	9	in	in	IN
cord-337365-hugenn14	219	10	microglia	microglia	NNS
cord-337365-hugenn14	219	11	.	.	.
cord-337365-hugenn14	220	1	In	in	IN
cord-337365-hugenn14	220	2	a	a	DT
cord-337365-hugenn14	220	3	mouse	mouse	NN
cord-337365-hugenn14	220	4	model	model	NN
cord-337365-hugenn14	220	5	of	of	IN
cord-337365-hugenn14	220	6	lethal	lethal	JJ
cord-337365-hugenn14	220	7	West	West	NNP
cord-337365-hugenn14	220	8	Nile	Nile	NNP
cord-337365-hugenn14	220	9	virus	virus	NN
cord-337365-hugenn14	220	10	(	(	-LRB-
cord-337365-hugenn14	220	11	WNV	WNV	NNP
cord-337365-hugenn14	220	12	)	)	-RRB-
cord-337365-hugenn14	220	13	infection	infection	NN
cord-337365-hugenn14	220	14	,	,	,
cord-337365-hugenn14	220	15	Peli1	peli1	NN
cord-337365-hugenn14	220	16	promotes	promote	VBZ
cord-337365-hugenn14	220	17	the	the	DT
cord-337365-hugenn14	220	18	production	production	NN
cord-337365-hugenn14	220	19	of	of	IN
cord-337365-hugenn14	220	20	pro	pro	JJ
cord-337365-hugenn14	220	21	-	-	JJ
cord-337365-hugenn14	220	22	inflammatory	inflammatory	JJ
cord-337365-hugenn14	220	23	cytokines	cytokine	NNS
cord-337365-hugenn14	220	24	and	and	CC
cord-337365-hugenn14	220	25	chemokines	chemokine	NNS
cord-337365-hugenn14	220	26	in	in	IN
cord-337365-hugenn14	220	27	microglia	microglia	NN
cord-337365-hugenn14	220	28	and	and	CC
cord-337365-hugenn14	220	29	promotes	promote	VBZ
cord-337365-hugenn14	220	30	the	the	DT
cord-337365-hugenn14	220	31	entry	entry	NN
cord-337365-hugenn14	220	32	of	of	IN
cord-337365-hugenn14	220	33	T	t	NN
cord-337365-hugenn14	220	34	cells	cell	NNS
cord-337365-hugenn14	220	35	and	and	CC
cord-337365-hugenn14	220	36	macrophages	macrophage	NNS
cord-337365-hugenn14	220	37	into	into	IN
cord-337365-hugenn14	220	38	the	the	DT
cord-337365-hugenn14	220	39	CNS	CNS	NNP
cord-337365-hugenn14	220	40	.	.	.
cord-337365-hugenn14	221	1	Peli1	Peli1	NNP
cord-337365-hugenn14	221	2	plays	play	VBZ
cord-337365-hugenn14	221	3	a	a	DT
cord-337365-hugenn14	221	4	crucial	crucial	JJ
cord-337365-hugenn14	221	5	role	role	NN
cord-337365-hugenn14	221	6	in	in	IN
cord-337365-hugenn14	221	7	WNV	WNV	NNP
cord-337365-hugenn14	221	8	entry	entry	NN
cord-337365-hugenn14	221	9	and	and	CC
cord-337365-hugenn14	221	10	replication	replication	NN
cord-337365-hugenn14	221	11	in	in	IN
cord-337365-hugenn14	221	12	human	human	JJ
cord-337365-hugenn14	221	13	and	and	CC
cord-337365-hugenn14	221	14	murine	murine	JJ
cord-337365-hugenn14	221	15	neurons	neuron	NNS
cord-337365-hugenn14	221	16	and	and	CC
cord-337365-hugenn14	221	17	microglia	microglia	NNS
cord-337365-hugenn14	221	18	(	(	-LRB-
cord-337365-hugenn14	221	19	see	see	VB
cord-337365-hugenn14	221	20	Fig	Fig	NNP
cord-337365-hugenn14	221	21	.	.	NNP
cord-337365-hugenn14	221	22	2	2	CD
cord-337365-hugenn14	221	23	)	)	-RRB-
cord-337365-hugenn14	221	24	.	.	.
cord-337365-hugenn14	222	1	Peli1	peli1	NN
cord-337365-hugenn14	222	2	promotes	promote	VBZ
cord-337365-hugenn14	222	3	adhesion	adhesion	NN
cord-337365-hugenn14	222	4	,	,	,
cord-337365-hugenn14	222	5	replication	replication	NN
cord-337365-hugenn14	222	6	,	,	,
cord-337365-hugenn14	222	7	and	and	CC
cord-337365-hugenn14	222	8	synthesis	synthesis	NN
cord-337365-hugenn14	222	9	of	of	IN
cord-337365-hugenn14	222	10	mature	mature	JJ
cord-337365-hugenn14	222	11	virions	virion	NNS
cord-337365-hugenn14	222	12	.	.	.
cord-337365-hugenn14	223	1	Autopsy	autopsy	JJ
cord-337365-hugenn14	223	2	of	of	IN
cord-337365-hugenn14	223	3	patients	patient	NNS
cord-337365-hugenn14	223	4	who	who	WP
cord-337365-hugenn14	223	5	died	die	VBD
cord-337365-hugenn14	223	6	of	of	IN
cord-337365-hugenn14	223	7	WNV	WNV	NNP
cord-337365-hugenn14	223	8	encephalitis	encephalitis	RB
cord-337365-hugenn14	223	9	found	find	VBD
cord-337365-hugenn14	223	10	that	that	IN
cord-337365-hugenn14	223	11	Peli1	peli1	NN
cord-337365-hugenn14	223	12	was	be	VBD
cord-337365-hugenn14	223	13	highly	highly	RB
cord-337365-hugenn14	223	14	expressed	express	VBN
cord-337365-hugenn14	223	15	on	on	IN
cord-337365-hugenn14	223	16	WNV	WNV	NNP
cord-337365-hugenn14	223	17	-	-	HYPH
cord-337365-hugenn14	223	18	infected	infect	VBN
cord-337365-hugenn14	223	19	neurons	neuron	NNS
cord-337365-hugenn14	223	20	and	and	CC
cord-337365-hugenn14	223	21	adjacent	adjacent	JJ
cord-337365-hugenn14	223	22	inflammatory	inflammatory	JJ
cord-337365-hugenn14	223	23	cells	cell	NNS
cord-337365-hugenn14	223	24	.	.	.
cord-337365-hugenn14	224	1	Peli1-deficient	peli1-deficient	JJ
cord-337365-hugenn14	224	2	microglia	microglia	NNS
cord-337365-hugenn14	224	3	and	and	CC
cord-337365-hugenn14	224	4	neurons	neuron	NNS
cord-337365-hugenn14	224	5	cause	cause	VBP
cord-337365-hugenn14	224	6	inflammation	inflammation	NN
cord-337365-hugenn14	224	7	and	and	CC
cord-337365-hugenn14	224	8	reduce	reduce	VB
cord-337365-hugenn14	224	9	host	host	NN
cord-337365-hugenn14	224	10	susceptibility	susceptibility	NN
cord-337365-hugenn14	224	11	to	to	IN
cord-337365-hugenn14	224	12	lethal	lethal	JJ
cord-337365-hugenn14	224	13	encephalitis	encephaliti	NNS
cord-337365-hugenn14	224	14	[	[	-LRB-
cord-337365-hugenn14	224	15	72	72	CD
cord-337365-hugenn14	224	16	]	]	-RRB-
cord-337365-hugenn14	224	17	.	.	.
cord-337365-hugenn14	225	1	Microglia	Microglia	NNP
cord-337365-hugenn14	225	2	are	be	VBP
cord-337365-hugenn14	225	3	the	the	DT
cord-337365-hugenn14	225	4	main	main	JJ
cord-337365-hugenn14	225	5	producers	producer	NNS
cord-337365-hugenn14	225	6	of	of	IN
cord-337365-hugenn14	225	7	central	central	JJ
cord-337365-hugenn14	225	8	nervous	nervous	JJ
cord-337365-hugenn14	225	9	system	system	NN
cord-337365-hugenn14	225	10	inflammatory	inflammatory	JJ
cord-337365-hugenn14	225	11	cytokines	cytokine	NNS
cord-337365-hugenn14	225	12	IL-6	IL-6	NNP
cord-337365-hugenn14	225	13	and	and	CC
cord-337365-hugenn14	225	14	TNF	TNF	NNP
cord-337365-hugenn14	225	15	-	-	HYPH
cord-337365-hugenn14	225	16	α	α	NNP
cord-337365-hugenn14	225	17	and	and	CC
cord-337365-hugenn14	225	18	chemokines	chemokine	NNS
cord-337365-hugenn14	225	19	CCL2	CCL2	NNP
cord-337365-hugenn14	225	20	and	and	CC
cord-337365-hugenn14	225	21	CXCL10	CXCL10	NNP
cord-337365-hugenn14	225	22	after	after	IN
cord-337365-hugenn14	225	23	WNV	WNV	NNP
cord-337365-hugenn14	225	24	infection	infection	NN
cord-337365-hugenn14	225	25	[	[	-LRB-
cord-337365-hugenn14	225	26	73	73	CD
cord-337365-hugenn14	225	27	]	]	-RRB-
cord-337365-hugenn14	225	28	.	.	.
cord-337365-hugenn14	226	1	The	the	DT
cord-337365-hugenn14	226	2	Peli1-deficient	Peli1-deficient	NNP
cord-337365-hugenn14	226	3	mice	mouse	NNS
cord-337365-hugenn14	226	4	have	have	VBP
cord-337365-hugenn14	226	5	better	well	JJR
cord-337365-hugenn14	226	6	resistance	resistance	NN
cord-337365-hugenn14	226	7	to	to	IN
cord-337365-hugenn14	226	8	WNV	WNV	NNP
cord-337365-hugenn14	226	9	,	,	,
cord-337365-hugenn14	226	10	reducing	reduce	VBG
cord-337365-hugenn14	226	11	levels	level	NNS
cord-337365-hugenn14	226	12	of	of	IN
cord-337365-hugenn14	226	13	cytokines	cytokine	NNS
cord-337365-hugenn14	226	14	and	and	CC
cord-337365-hugenn14	226	15	chemokines	chemokine	NNS
cord-337365-hugenn14	226	16	in	in	IN
cord-337365-hugenn14	226	17	the	the	DT
cord-337365-hugenn14	226	18	body	body	NN
cord-337365-hugenn14	226	19	,	,	,
cord-337365-hugenn14	226	20	including	include	VBG
cord-337365-hugenn14	226	21	IL-6	IL-6	NNP
cord-337365-hugenn14	226	22	,	,	,
cord-337365-hugenn14	226	23	TNF	TNF	NNP
cord-337365-hugenn14	226	24	-	-	HYPH
cord-337365-hugenn14	226	25	α	α	NNP
cord-337365-hugenn14	226	26	,	,	,
cord-337365-hugenn14	226	27	IL-1β	IL-1β	NNP
cord-337365-hugenn14	226	28	,	,	,
cord-337365-hugenn14	226	29	and	and	CC
cord-337365-hugenn14	226	30	IL-10	IL-10	NNP
cord-337365-hugenn14	226	31	and	and	CC
cord-337365-hugenn14	226	32	CCL2	CCL2	NNP
cord-337365-hugenn14	226	33	and	and	CC
cord-337365-hugenn14	226	34	CCL5	CCL5	NNP
cord-337365-hugenn14	226	35	[	[	-LRB-
cord-337365-hugenn14	226	36	72	72	CD
cord-337365-hugenn14	226	37	]	]	-RRB-
cord-337365-hugenn14	226	38	.	.	.
cord-337365-hugenn14	227	1	Peli1	peli1	NN
cord-337365-hugenn14	227	2	expressed	express	VBN
cord-337365-hugenn14	227	3	in	in	IN
cord-337365-hugenn14	227	4	microglia	microglia	NNP
cord-337365-hugenn14	227	5	can	can	MD
cord-337365-hugenn14	227	6	promote	promote	VB
cord-337365-hugenn14	227	7	the	the	DT
cord-337365-hugenn14	227	8	degradation	degradation	NN
cord-337365-hugenn14	227	9	of	of	IN
cord-337365-hugenn14	227	10	TNF	TNF	NNP
cord-337365-hugenn14	227	11	receptor	receptor	NN
cord-337365-hugenn14	227	12	-	-	HYPH
cord-337365-hugenn14	227	13	associated	associate	VBN
cord-337365-hugenn14	227	14	factor	factor	NN
cord-337365-hugenn14	227	15	3	3	CD
cord-337365-hugenn14	227	16	(	(	-LRB-
cord-337365-hugenn14	227	17	Traf3	Traf3	NNP
cord-337365-hugenn14	227	18	)	)	-RRB-
cord-337365-hugenn14	227	19	by	by	IN
cord-337365-hugenn14	227	20	regulating	regulate	VBG
cord-337365-hugenn14	227	21	TLR	TLR	NNP
cord-337365-hugenn14	227	22	/	/	SYM
cord-337365-hugenn14	227	23	MyD88	MyD88	NNP
cord-337365-hugenn14	227	24	signaling	signal	VBG
cord-337365-hugenn14	227	25	and	and	CC
cord-337365-hugenn14	227	26	can	can	MD
cord-337365-hugenn14	227	27	activate	activate	VB
cord-337365-hugenn14	227	28	microglia	microglia	NNS
cord-337365-hugenn14	227	29	during	during	IN
cord-337365-hugenn14	227	30	the	the	DT
cord-337365-hugenn14	227	31	induction	induction	NN
cord-337365-hugenn14	227	32	of	of	IN
cord-337365-hugenn14	227	33	experimental	experimental	JJ
cord-337365-hugenn14	227	34	autoimmune	autoimmune	JJ
cord-337365-hugenn14	227	35	encephalomyelitis	encephalomyelitis	NN
cord-337365-hugenn14	227	36	(	(	-LRB-
cord-337365-hugenn14	227	37	EAE	EAE	NNP
cord-337365-hugenn14	227	38	)	)	-RRB-
cord-337365-hugenn14	227	39	[	[	-LRB-
cord-337365-hugenn14	227	40	74	74	CD
cord-337365-hugenn14	227	41	]	]	-RRB-
cord-337365-hugenn14	227	42	.	.	.
cord-337365-hugenn14	228	1	It	-PRON-	PRP
cord-337365-hugenn14	228	2	is	be	VBZ
cord-337365-hugenn14	228	3	well	well	RB
cord-337365-hugenn14	228	4	known	know	VBN
cord-337365-hugenn14	228	5	that	that	IN
cord-337365-hugenn14	228	6	microglia	microglia	NNS
cord-337365-hugenn14	228	7	respond	respond	VBP
cord-337365-hugenn14	228	8	to	to	IN
cord-337365-hugenn14	228	9	viral	viral	JJ
cord-337365-hugenn14	228	10	infection	infection	NN
cord-337365-hugenn14	228	11	by	by	IN
cord-337365-hugenn14	228	12	activating	activate	VBG
cord-337365-hugenn14	228	13	p38MAPK	p38MAPK	NNPS
cord-337365-hugenn14	228	14	[	[	-LRB-
cord-337365-hugenn14	228	15	75	75	CD
cord-337365-hugenn14	228	16	]	]	-RRB-
cord-337365-hugenn14	228	17	.	.	.
cord-337365-hugenn14	229	1	In	in	IN
cord-337365-hugenn14	229	2	WNV	WNV	NNP
cord-337365-hugenn14	229	3	-	-	HYPH
cord-337365-hugenn14	229	4	infected	infect	VBN
cord-337365-hugenn14	229	5	Peli1	peli1	NN
cord-337365-hugenn14	229	6	−/−	−/−	NNP
cord-337365-hugenn14	229	7	neurons	neuron	NNS
cord-337365-hugenn14	229	8	,	,	,
cord-337365-hugenn14	229	9	phosphorylation	phosphorylation	NN
cord-337365-hugenn14	229	10	levels	level	NNS
cord-337365-hugenn14	229	11	of	of	IN
cord-337365-hugenn14	229	12	p38MAPK	p38MAPK	NNPS
cord-337365-hugenn14	229	13	and	and	CC
cord-337365-hugenn14	229	14	p65	p65	CD
cord-337365-hugenn14	229	15	decreased	decrease	VBD
cord-337365-hugenn14	229	16	,	,	,
cord-337365-hugenn14	229	17	indicating	indicate	VBG
cord-337365-hugenn14	229	18	that	that	IN
cord-337365-hugenn14	229	19	Peli1	peli1	NN
cord-337365-hugenn14	229	20	plays	play	VBZ
cord-337365-hugenn14	229	21	a	a	DT
cord-337365-hugenn14	229	22	positive	positive	JJ
cord-337365-hugenn14	229	23	regulatory	regulatory	JJ
cord-337365-hugenn14	229	24	role	role	NN
cord-337365-hugenn14	229	25	in	in	IN
cord-337365-hugenn14	229	26	NF	NF	NNP
cord-337365-hugenn14	229	27	-	-	HYPH
cord-337365-hugenn14	229	28	κB	κB	NNP
cord-337365-hugenn14	229	29	and	and	CC
cord-337365-hugenn14	229	30	p38MAPK	p38MAPK	NNP
cord-337365-hugenn14	229	31	activation	activation	NN
cord-337365-hugenn14	229	32	[	[	-LRB-
cord-337365-hugenn14	229	33	72	72	CD
cord-337365-hugenn14	229	34	]	]	-RRB-
cord-337365-hugenn14	229	35	.	.	.
cord-337365-hugenn14	230	1	Peli1	peli1	NN
cord-337365-hugenn14	230	2	facilitates	facilitate	VBZ
cord-337365-hugenn14	230	3	WNV	WNV	NNP
cord-337365-hugenn14	230	4	replication	replication	NN
cord-337365-hugenn14	230	5	in	in	IN
cord-337365-hugenn14	230	6	microglia	microglia	NN
cord-337365-hugenn14	230	7	and	and	CC
cord-337365-hugenn14	230	8	neurons	neuron	NNS
cord-337365-hugenn14	230	9	,	,	,
cord-337365-hugenn14	230	10	especially	especially	RB
cord-337365-hugenn14	230	11	in	in	IN
cord-337365-hugenn14	230	12	the	the	DT
cord-337365-hugenn14	230	13	latter	latter	JJ
cord-337365-hugenn14	230	14	,	,	,
cord-337365-hugenn14	230	15	which	which	WDT
cord-337365-hugenn14	230	16	are	be	VBP
cord-337365-hugenn14	230	17	the	the	DT
cord-337365-hugenn14	230	18	major	major	JJ
cord-337365-hugenn14	230	19	cells	cell	NNS
cord-337365-hugenn14	230	20	infected	infect	VBN
cord-337365-hugenn14	230	21	during	during	IN
cord-337365-hugenn14	230	22	in	in	IN
cord-337365-hugenn14	230	23	vivo	vivo	NN
cord-337365-hugenn14	230	24	challenge	challenge	NN
cord-337365-hugenn14	230	25	.	.	.
cord-337365-hugenn14	231	1	It	-PRON-	PRP
cord-337365-hugenn14	231	2	also	also	RB
cord-337365-hugenn14	231	3	positively	positively	RB
cord-337365-hugenn14	231	4	mediates	mediate	VBZ
cord-337365-hugenn14	231	5	NF	nf	NN
cord-337365-hugenn14	231	6	-	-	HYPH
cord-337365-hugenn14	231	7	κB	κB	NNP
cord-337365-hugenn14	232	1	and/or	and/or	CC
cord-337365-hugenn14	233	1	p38MAPK	p38MAPK	NNP
cord-337365-hugenn14	233	2	activation	activation	NN
cord-337365-hugenn14	233	3	in	in	IN
cord-337365-hugenn14	233	4	these	these	DT
cord-337365-hugenn14	233	5	cells	cell	NNS
cord-337365-hugenn14	233	6	and	and	CC
cord-337365-hugenn14	233	7	boosts	boost	VBZ
cord-337365-hugenn14	233	8	a	a	DT
cord-337365-hugenn14	233	9	robust	robust	JJ
cord-337365-hugenn14	233	10	production	production	NN
cord-337365-hugenn14	233	11	of	of	IN
cord-337365-hugenn14	233	12	inflammatory	inflammatory	JJ
cord-337365-hugenn14	233	13	cytokines	cytokine	NNS
cord-337365-hugenn14	233	14	and	and	CC
cord-337365-hugenn14	233	15	chemokines	chemokine	NNS
cord-337365-hugenn14	233	16	,	,	,
cord-337365-hugenn14	233	17	which	which	WDT
cord-337365-hugenn14	233	18	attracts	attract	VBZ
cord-337365-hugenn14	233	19	more	more	JJR
cord-337365-hugenn14	233	20	infiltration	infiltration	NN
cord-337365-hugenn14	233	21	of	of	IN
cord-337365-hugenn14	233	22	inflammatory	inflammatory	JJ
cord-337365-hugenn14	233	23	cells	cell	NNS
cord-337365-hugenn14	233	24	from	from	IN
cord-337365-hugenn14	233	25	the	the	DT
cord-337365-hugenn14	233	26	periphery	periphery	NN
cord-337365-hugenn14	233	27	and	and	CC
cord-337365-hugenn14	233	28	ultimately	ultimately	RB
cord-337365-hugenn14	233	29	contributes	contribute	VBZ
cord-337365-hugenn14	233	30	to	to	IN
cord-337365-hugenn14	233	31	lethal	lethal	JJ
cord-337365-hugenn14	233	32	WNV	WNV	NNP
cord-337365-hugenn14	233	33	encephalitis	encephalitis	RB
cord-337365-hugenn14	233	34	.	.	.
cord-337365-hugenn14	234	1	Thus	thus	RB
cord-337365-hugenn14	234	2	,	,	,
cord-337365-hugenn14	234	3	Peli1	peli1	NN
cord-337365-hugenn14	234	4	synergistically	synergistically	RB
cord-337365-hugenn14	234	5	promotes	promote	VBZ
cord-337365-hugenn14	234	6	virus	virus	NN
cord-337365-hugenn14	234	7	dissemination	dissemination	NN
cord-337365-hugenn14	234	8	and	and	CC
cord-337365-hugenn14	234	9	inflammation	inflammation	NN
cord-337365-hugenn14	234	10	in	in	IN
cord-337365-hugenn14	234	11	the	the	DT
cord-337365-hugenn14	234	12	CNS	CNS	NNP
cord-337365-hugenn14	234	13	[	[	-LRB-
cord-337365-hugenn14	234	14	72	72	CD
cord-337365-hugenn14	234	15	]	]	-RRB-
cord-337365-hugenn14	234	16	.	.	.
cord-337365-hugenn14	235	1	Under	under	IN
cord-337365-hugenn14	235	2	physiological	physiological	JJ
cord-337365-hugenn14	235	3	conditions	condition	NNS
cord-337365-hugenn14	235	4	,	,	,
cord-337365-hugenn14	235	5	neurons	neuron	NNS
cord-337365-hugenn14	235	6	can	can	MD
cord-337365-hugenn14	235	7	produce	produce	VB
cord-337365-hugenn14	235	8	trace	trace	NN
cord-337365-hugenn14	235	9	amounts	amount	NNS
cord-337365-hugenn14	235	10	of	of	IN
cord-337365-hugenn14	235	11	amyloid	amyloid	NN
cord-337365-hugenn14	235	12	-	-	HYPH
cord-337365-hugenn14	235	13	β	β	NN
cord-337365-hugenn14	235	14	peptide	peptide	NN
cord-337365-hugenn14	235	15	(	(	-LRB-
cord-337365-hugenn14	235	16	Aβ	Aβ	NNP
cord-337365-hugenn14	235	17	)	)	-RRB-
cord-337365-hugenn14	235	18	to	to	TO
cord-337365-hugenn14	235	19	maintain	maintain	VB
cord-337365-hugenn14	235	20	synaptic	synaptic	JJ
cord-337365-hugenn14	235	21	plasticity	plasticity	NN
cord-337365-hugenn14	235	22	and	and	CC
cord-337365-hugenn14	235	23	memory	memory	NN
cord-337365-hugenn14	235	24	and	and	CC
cord-337365-hugenn14	235	25	play	play	VB
cord-337365-hugenn14	235	26	an	an	DT
cord-337365-hugenn14	235	27	antimicrobial	antimicrobial	JJ
cord-337365-hugenn14	235	28	role	role	NN
cord-337365-hugenn14	235	29	.	.	.
cord-337365-hugenn14	236	1	The	the	DT
cord-337365-hugenn14	236	2	clearance	clearance	NN
cord-337365-hugenn14	236	3	of	of	IN
cord-337365-hugenn14	236	4	Aβ	Aβ	NNP
cord-337365-hugenn14	236	5	is	be	VBZ
cord-337365-hugenn14	236	6	achieved	achieve	VBN
cord-337365-hugenn14	236	7	by	by	IN
cord-337365-hugenn14	236	8	phagocytosis	phagocytosis	NN
cord-337365-hugenn14	236	9	of	of	IN
cord-337365-hugenn14	236	10	microglia	microglia	NNS
cord-337365-hugenn14	236	11	.	.	.
cord-337365-hugenn14	237	1	HSV	HSV	NNP
cord-337365-hugenn14	237	2	reactivation	reactivation	NN
cord-337365-hugenn14	237	3	would	would	MD
cord-337365-hugenn14	237	4	trigger	trigger	VB
cord-337365-hugenn14	237	5	increased	increase	VBN
cord-337365-hugenn14	237	6	Aβ	Aβ	NNP
cord-337365-hugenn14	237	7	production	production	NN
cord-337365-hugenn14	237	8	,	,	,
cord-337365-hugenn14	237	9	activation	activation	NN
cord-337365-hugenn14	237	10	of	of	IN
cord-337365-hugenn14	237	11	microglia	microglia	NN
cord-337365-hugenn14	237	12	,	,	,
cord-337365-hugenn14	237	13	and	and	CC
cord-337365-hugenn14	237	14	release	release	NN
cord-337365-hugenn14	237	15	of	of	IN
cord-337365-hugenn14	237	16	pro	pro	JJ
cord-337365-hugenn14	237	17	-	-	JJ
cord-337365-hugenn14	237	18	inflammatory	inflammatory	JJ
cord-337365-hugenn14	237	19	cytokines	cytokine	NNS
cord-337365-hugenn14	237	20	(	(	-LRB-
cord-337365-hugenn14	237	21	pathological	pathological	JJ
cord-337365-hugenn14	237	22	state	state	NN
cord-337365-hugenn14	237	23	)	)	-RRB-
cord-337365-hugenn14	237	24	that	that	WDT
cord-337365-hugenn14	237	25	would	would	MD
cord-337365-hugenn14	237	26	sustain	sustain	VB
cord-337365-hugenn14	237	27	microglia	microglia	JJ
cord-337365-hugenn14	237	28	activation	activation	NN
cord-337365-hugenn14	237	29	and	and	CC
cord-337365-hugenn14	237	30	initiate	initiate	VB
cord-337365-hugenn14	237	31	a	a	DT
cord-337365-hugenn14	237	32	vicious	vicious	JJ
cord-337365-hugenn14	237	33	circle	circle	NN
cord-337365-hugenn14	237	34	of	of	IN
cord-337365-hugenn14	237	35	inflammatory	inflammatory	JJ
cord-337365-hugenn14	237	36	responses	response	NNS
cord-337365-hugenn14	237	37	.	.	.
cord-337365-hugenn14	238	1	Recurrence	recurrence	NN
cord-337365-hugenn14	238	2	of	of	IN
cord-337365-hugenn14	238	3	this	this	DT
cord-337365-hugenn14	238	4	series	series	NN
cord-337365-hugenn14	238	5	of	of	IN
cord-337365-hugenn14	238	6	events	event	NNS
cord-337365-hugenn14	238	7	during	during	IN
cord-337365-hugenn14	238	8	life	life	NN
cord-337365-hugenn14	238	9	would	would	MD
cord-337365-hugenn14	238	10	result	result	VB
cord-337365-hugenn14	238	11	in	in	IN
cord-337365-hugenn14	238	12	amplification	amplification	NN
cord-337365-hugenn14	238	13	and	and	CC
cord-337365-hugenn14	238	14	irreversible	irreversible	JJ
cord-337365-hugenn14	238	15	damage	damage	NN
cord-337365-hugenn14	238	16	to	to	IN
cord-337365-hugenn14	238	17	hippocampus	hippocampus	NN
cord-337365-hugenn14	238	18	[	[	-LRB-
cord-337365-hugenn14	238	19	76	76	CD
cord-337365-hugenn14	238	20	]	]	-RRB-
cord-337365-hugenn14	238	21	.	.	.
cord-337365-hugenn14	239	1	Studies	study	NNS
cord-337365-hugenn14	239	2	have	have	VBP
cord-337365-hugenn14	239	3	shown	show	VBN
cord-337365-hugenn14	239	4	that	that	IN
cord-337365-hugenn14	239	5	Aβ	Aβ	NNP
cord-337365-hugenn14	239	6	oligomers	oligomer	NNS
cord-337365-hugenn14	239	7	can	can	MD
cord-337365-hugenn14	239	8	bind	bind	VB
cord-337365-hugenn14	239	9	glycoproteins	glycoprotein	NNS
cord-337365-hugenn14	239	10	on	on	IN
cord-337365-hugenn14	239	11	the	the	DT
cord-337365-hugenn14	239	12	surface	surface	NN
cord-337365-hugenn14	239	13	of	of	IN
cord-337365-hugenn14	239	14	herpesvirus	herpesvirus	NN
cord-337365-hugenn14	239	15	and	and	CC
cord-337365-hugenn14	239	16	accelerate	accelerate	VB
cord-337365-hugenn14	239	17	Aβ	Aβ	NNP
cord-337365-hugenn14	239	18	deposition	deposition	NN
cord-337365-hugenn14	239	19	showing	show	VBG
cord-337365-hugenn14	239	20	protective	protective	JJ
cord-337365-hugenn14	239	21	viral	viral	JJ
cord-337365-hugenn14	239	22	entrapment	entrapment	NN
cord-337365-hugenn14	239	23	activity	activity	NN
cord-337365-hugenn14	239	24	in	in	IN
cord-337365-hugenn14	239	25	5XFAD	5xfad	CD
cord-337365-hugenn14	239	26	mouse	mouse	NN
cord-337365-hugenn14	239	27	and	and	CC
cord-337365-hugenn14	239	28	3D	3D	NNP
cord-337365-hugenn14	239	29	human	human	JJ
cord-337365-hugenn14	239	30	neural	neural	JJ
cord-337365-hugenn14	239	31	cell	cell	NN
cord-337365-hugenn14	239	32	culture	culture	NN
cord-337365-hugenn14	239	33	infection	infection	NN
cord-337365-hugenn14	239	34	models	model	NNS
cord-337365-hugenn14	239	35	against	against	IN
cord-337365-hugenn14	239	36	neurotropic	neurotropic	NNP
cord-337365-hugenn14	239	37	HSV1	HSV1	NNP
cord-337365-hugenn14	239	38	.	.	.
cord-337365-hugenn14	240	1	This	this	DT
cord-337365-hugenn14	240	2	indicates	indicate	VBZ
cord-337365-hugenn14	240	3	that	that	IN
cord-337365-hugenn14	240	4	Aβ	Aβ	NNP
cord-337365-hugenn14	240	5	fibrils	fibril	NNS
cord-337365-hugenn14	240	6	and	and	CC
cord-337365-hugenn14	240	7	deposits	deposit	NNS
cord-337365-hugenn14	240	8	may	may	MD
cord-337365-hugenn14	240	9	be	be	VB
cord-337365-hugenn14	240	10	important	important	JJ
cord-337365-hugenn14	240	11	in	in	IN
cord-337365-hugenn14	240	12	protecting	protect	VBG
cord-337365-hugenn14	240	13	the	the	DT
cord-337365-hugenn14	240	14	brain	brain	NN
cord-337365-hugenn14	240	15	from	from	IN
cord-337365-hugenn14	240	16	common	common	JJ
cord-337365-hugenn14	240	17	viral	viral	JJ
cord-337365-hugenn14	240	18	infections	infection	NNS
cord-337365-hugenn14	240	19	[	[	-LRB-
cord-337365-hugenn14	240	20	77	77	CD
cord-337365-hugenn14	240	21	]	]	-RRB-
cord-337365-hugenn14	240	22	.	.	.
cord-337365-hugenn14	241	1	Carbohydrate	carbohydrate	NN
cord-337365-hugenn14	241	2	-	-	HYPH
cord-337365-hugenn14	241	3	binding	binding	NN
cord-337365-hugenn14	241	4	promotes	promote	VBZ
cord-337365-hugenn14	241	5	Aβ	Aβ	NNP
cord-337365-hugenn14	241	6	fibrillization	fibrillization	NN
cord-337365-hugenn14	241	7	and	and	CC
cord-337365-hugenn14	241	8	leads	lead	VBZ
cord-337365-hugenn14	241	9	to	to	IN
cord-337365-hugenn14	241	10	protofibril	protofibril	VB
cord-337365-hugenn14	241	11	generation	generation	NN
cord-337365-hugenn14	241	12	on	on	IN
cord-337365-hugenn14	241	13	microbial	microbial	JJ
cord-337365-hugenn14	241	14	surfaces	surface	NNS
cord-337365-hugenn14	241	15	.	.	.
cord-337365-hugenn14	242	1	Bound	bind	VBN
cord-337365-hugenn14	242	2	protofibrils	protofibril	NNS
cord-337365-hugenn14	242	3	first	first	RB
cord-337365-hugenn14	242	4	inhibit	inhibit	VBP
cord-337365-hugenn14	242	5	host	host	NN
cord-337365-hugenn14	242	6	cell	cell	NN
cord-337365-hugenn14	242	7	adhesion	adhesion	NN
cord-337365-hugenn14	242	8	by	by	IN
cord-337365-hugenn14	242	9	pathogens	pathogen	NNS
cord-337365-hugenn14	242	10	.	.	.
cord-337365-hugenn14	243	1	Then	then	RB
cord-337365-hugenn14	243	2	,	,	,
cord-337365-hugenn14	243	3	propagating	propagate	VBG
cord-337365-hugenn14	243	4	Aβ	Aβ	NNP
cord-337365-hugenn14	243	5	fibrils	fibril	NNS
cord-337365-hugenn14	243	6	mediate	mediate	VBP
cord-337365-hugenn14	243	7	agglutination	agglutination	NN
cord-337365-hugenn14	243	8	and	and	CC
cord-337365-hugenn14	243	9	sequestration	sequestration	NN
cord-337365-hugenn14	243	10	of	of	IN
cord-337365-hugenn14	243	11	microbes	microbe	NNS
cord-337365-hugenn14	243	12	within	within	IN
cord-337365-hugenn14	243	13	fibrillar	fibrillar	NNP
cord-337365-hugenn14	243	14	β	β	NN
cord-337365-hugenn14	243	15	-	-	HYPH
cord-337365-hugenn14	243	16	amyloid	amyloid	NNP
cord-337365-hugenn14	243	17	.	.	.
cord-337365-hugenn14	244	1	When	when	WRB
cord-337365-hugenn14	244	2	the	the	DT
cord-337365-hugenn14	244	3	Aβ	Aβ	NNP
cord-337365-hugenn14	244	4	oligomer	oligomer	RB
cord-337365-hugenn14	244	5	-	-	HYPH
cord-337365-hugenn14	244	6	mediated	mediate	VBN
cord-337365-hugenn14	244	7	protective	protective	JJ
cord-337365-hugenn14	244	8	antimicrobial	antimicrobial	JJ
cord-337365-hugenn14	244	9	pathway	pathway	NN
cord-337365-hugenn14	244	10	is	be	VBZ
cord-337365-hugenn14	244	11	over	over	RB
cord-337365-hugenn14	244	12	-	-	HYPH
cord-337365-hugenn14	244	13	activated	activate	VBN
cord-337365-hugenn14	244	14	,	,	,
cord-337365-hugenn14	244	15	progressive	progressive	JJ
cord-337365-hugenn14	244	16	Aβ	Aβ	NNP
cord-337365-hugenn14	244	17	deposition	deposition	NN
cord-337365-hugenn14	244	18	can	can	MD
cord-337365-hugenn14	244	19	cause	cause	VB
cord-337365-hugenn14	244	20	neuroinflammation	neuroinflammation	NN
cord-337365-hugenn14	244	21	,	,	,
cord-337365-hugenn14	244	22	neuropathology	neuropathology	NN
cord-337365-hugenn14	244	23	,	,	,
cord-337365-hugenn14	244	24	and	and	CC
cord-337365-hugenn14	244	25	extensive	extensive	JJ
cord-337365-hugenn14	244	26	neuronal	neuronal	JJ
cord-337365-hugenn14	244	27	death	death	NN
cord-337365-hugenn14	244	28	,	,	,
cord-337365-hugenn14	244	29	leading	lead	VBG
cord-337365-hugenn14	244	30	to	to	IN
cord-337365-hugenn14	244	31	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	244	32	's	's	POS
cord-337365-hugenn14	244	33	disease	disease	NN
cord-337365-hugenn14	244	34	(	(	-LRB-
cord-337365-hugenn14	244	35	AD	ad	NN
cord-337365-hugenn14	244	36	)	)	-RRB-
cord-337365-hugenn14	244	37	,	,	,
cord-337365-hugenn14	244	38	a	a	DT
cord-337365-hugenn14	244	39	model	model	NN
cord-337365-hugenn14	244	40	called	call	VBN
cord-337365-hugenn14	244	41	antimicrobial	antimicrobial	JJ
cord-337365-hugenn14	244	42	protection	protection	NN
cord-337365-hugenn14	244	43	hypothesis	hypothesis	NN
cord-337365-hugenn14	244	44	[	[	-LRB-
cord-337365-hugenn14	244	45	77	77	CD
cord-337365-hugenn14	244	46	]	]	-RRB-
cord-337365-hugenn14	244	47	.	.	.
cord-337365-hugenn14	245	1	Recently	recently	RB
cord-337365-hugenn14	245	2	,	,	,
cord-337365-hugenn14	245	3	a	a	DT
cord-337365-hugenn14	245	4	16-year	16-year	JJ
cord-337365-hugenn14	245	5	study	study	NN
cord-337365-hugenn14	245	6	involving	involve	VBG
cord-337365-hugenn14	245	7	more	more	JJR
cord-337365-hugenn14	245	8	than	than	IN
cord-337365-hugenn14	245	9	33,000	33,000	CD
cord-337365-hugenn14	245	10	patients	patient	NNS
cord-337365-hugenn14	245	11	found	find	VBD
cord-337365-hugenn14	245	12	that	that	IN
cord-337365-hugenn14	245	13	HSV	HSV	NNP
cord-337365-hugenn14	245	14	1	1	CD
cord-337365-hugenn14	245	15	infection	infection	NN
cord-337365-hugenn14	245	16	increased	increase	VBD
cord-337365-hugenn14	245	17	the	the	DT
cord-337365-hugenn14	245	18	risk	risk	NN
cord-337365-hugenn14	245	19	of	of	IN
cord-337365-hugenn14	245	20	dementia	dementia	NN
cord-337365-hugenn14	245	21	by	by	IN
cord-337365-hugenn14	245	22	2.56	2.56	CD
cord-337365-hugenn14	245	23	times	time	NNS
cord-337365-hugenn14	245	24	.	.	.
cord-337365-hugenn14	246	1	And	and	CC
cord-337365-hugenn14	246	2	long	long	JJ
cord-337365-hugenn14	246	3	-	-	HYPH
cord-337365-hugenn14	246	4	term	term	NN
cord-337365-hugenn14	246	5	use	use	NN
cord-337365-hugenn14	246	6	of	of	IN
cord-337365-hugenn14	246	7	anti	anti	JJ
cord-337365-hugenn14	246	8	-	-	JJ
cord-337365-hugenn14	246	9	herpes	herpes	JJ
cord-337365-hugenn14	246	10	drugs	drug	NNS
cord-337365-hugenn14	246	11	seems	seem	VBZ
cord-337365-hugenn14	246	12	to	to	TO
cord-337365-hugenn14	246	13	reduce	reduce	VB
cord-337365-hugenn14	246	14	the	the	DT
cord-337365-hugenn14	246	15	risk	risk	NN
cord-337365-hugenn14	246	16	of	of	IN
cord-337365-hugenn14	246	17	dementia	dementia	NN
cord-337365-hugenn14	246	18	in	in	IN
cord-337365-hugenn14	246	19	patients	patient	NNS
cord-337365-hugenn14	246	20	with	with	IN
cord-337365-hugenn14	246	21	HSV-1	hsv-1	NN
cord-337365-hugenn14	246	22	infection	infection	NN
cord-337365-hugenn14	246	23	.	.	.
cord-337365-hugenn14	247	1	In	in	IN
cord-337365-hugenn14	247	2	general	general	JJ
cord-337365-hugenn14	247	3	,	,	,
cord-337365-hugenn14	247	4	patients	patient	NNS
cord-337365-hugenn14	247	5	with	with	IN
cord-337365-hugenn14	247	6	shorter	short	JJR
cord-337365-hugenn14	247	7	(	(	-LRB-
cord-337365-hugenn14	247	8	<	<	NNP
cord-337365-hugenn14	247	9	30	30	CD
cord-337365-hugenn14	247	10	days	day	NNS
cord-337365-hugenn14	247	11	)	)	-RRB-
cord-337365-hugenn14	247	12	or	or	CC
cord-337365-hugenn14	247	13	longer	long	RBR
cord-337365-hugenn14	247	14	(	(	-LRB-
cord-337365-hugenn14	247	15	≧	≧	NNP
cord-337365-hugenn14	247	16	30	30	CD
cord-337365-hugenn14	247	17	days	day	NNS
cord-337365-hugenn14	247	18	)	)	-RRB-
cord-337365-hugenn14	247	19	durations	duration	NNS
cord-337365-hugenn14	247	20	of	of	IN
cord-337365-hugenn14	247	21	anti	anti	JJ
cord-337365-hugenn14	247	22	-	-	JJ
cord-337365-hugenn14	247	23	herpetic	herpetic	JJ
cord-337365-hugenn14	247	24	medications	medication	NNS
cord-337365-hugenn14	247	25	were	be	VBD
cord-337365-hugenn14	247	26	associated	associate	VBN
cord-337365-hugenn14	247	27	with	with	IN
cord-337365-hugenn14	247	28	a	a	DT
cord-337365-hugenn14	247	29	decreased	decreased	JJ
cord-337365-hugenn14	247	30	risk	risk	NN
cord-337365-hugenn14	247	31	of	of	IN
cord-337365-hugenn14	247	32	dementia	dementia	NN
cord-337365-hugenn14	247	33	,	,	,
cord-337365-hugenn14	247	34	and	and	CC
cord-337365-hugenn14	247	35	the	the	DT
cord-337365-hugenn14	247	36	treatment	treatment	NN
cord-337365-hugenn14	247	37	duration	duration	NN
cord-337365-hugenn14	247	38	of	of	IN
cord-337365-hugenn14	247	39	≧	≧	DT
cord-337365-hugenn14	247	40	30	30	CD
cord-337365-hugenn14	247	41	days	day	NNS
cord-337365-hugenn14	247	42	was	be	VBD
cord-337365-hugenn14	247	43	associated	associate	VBN
cord-337365-hugenn14	247	44	with	with	IN
cord-337365-hugenn14	247	45	a	a	DT
cord-337365-hugenn14	247	46	lower	low	JJR
cord-337365-hugenn14	247	47	risk	risk	NN
cord-337365-hugenn14	247	48	of	of	IN
cord-337365-hugenn14	247	49	dementia	dementia	NN
cord-337365-hugenn14	247	50	than	than	IN
cord-337365-hugenn14	247	51	those	those	DT
cord-337365-hugenn14	247	52	of	of	IN
cord-337365-hugenn14	247	53	a	a	DT
cord-337365-hugenn14	247	54	duration	duration	NN
cord-337365-hugenn14	247	55	of	of	IN
cord-337365-hugenn14	247	56	<	<	$
cord-337365-hugenn14	247	57	30	30	CD
cord-337365-hugenn14	247	58	days	day	NNS
cord-337365-hugenn14	247	59	[	[	-LRB-
cord-337365-hugenn14	247	60	78	78	CD
cord-337365-hugenn14	247	61	]	]	-RRB-
cord-337365-hugenn14	247	62	.	.	.
cord-337365-hugenn14	248	1	Microglia	Microglia	NNP
cord-337365-hugenn14	248	2	have	have	VBP
cord-337365-hugenn14	248	3	been	be	VBN
cord-337365-hugenn14	248	4	involved	involve	VBN
cord-337365-hugenn14	248	5	in	in	IN
cord-337365-hugenn14	248	6	AD	ad	NN
cord-337365-hugenn14	248	7	for	for	IN
cord-337365-hugenn14	248	8	more	more	JJR
cord-337365-hugenn14	248	9	than	than	IN
cord-337365-hugenn14	248	10	100	100	CD
cord-337365-hugenn14	248	11	years	year	NNS
cord-337365-hugenn14	248	12	.	.	.
cord-337365-hugenn14	249	1	Nissl	Nissl	NNP
cord-337365-hugenn14	249	2	and	and	CC
cord-337365-hugenn14	249	3	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	249	4	first	first	RB
cord-337365-hugenn14	249	5	described	describe	VBD
cord-337365-hugenn14	249	6	amoebalike	amoebalike	JJ
cord-337365-hugenn14	249	7	glial	glial	JJ
cord-337365-hugenn14	249	8	cells	cell	NNS
cord-337365-hugenn14	249	9	in	in	IN
cord-337365-hugenn14	249	10	various	various	JJ
cord-337365-hugenn14	249	11	neurological	neurological	JJ
cord-337365-hugenn14	249	12	states	state	NNS
cord-337365-hugenn14	249	13	in	in	IN
cord-337365-hugenn14	249	14	1904	1904	CD
cord-337365-hugenn14	249	15	and	and	CC
cord-337365-hugenn14	249	16	1910	1910	CD
cord-337365-hugenn14	249	17	.	.	.
cord-337365-hugenn14	250	1	This	this	DT
cord-337365-hugenn14	250	2	amoeba	amoeba	NN
cord-337365-hugenn14	250	3	-	-	HYPH
cord-337365-hugenn14	250	4	like	like	JJ
cord-337365-hugenn14	250	5	glial	glial	JJ
cord-337365-hugenn14	250	6	cell	cell	NN
cord-337365-hugenn14	250	7	was	be	VBD
cord-337365-hugenn14	250	8	later	later	RB
cord-337365-hugenn14	250	9	confirmed	confirm	VBN
cord-337365-hugenn14	250	10	to	to	TO
cord-337365-hugenn14	250	11	be	be	VB
cord-337365-hugenn14	250	12	a	a	DT
cord-337365-hugenn14	250	13	microglia	microglia	NN
cord-337365-hugenn14	250	14	.	.	.
cord-337365-hugenn14	251	1	Microglia	Microglia	NNP
cord-337365-hugenn14	251	2	were	be	VBD
cord-337365-hugenn14	251	3	activated	activate	VBN
cord-337365-hugenn14	251	4	in	in	IN
cord-337365-hugenn14	251	5	amyloid	amyloid	NN
cord-337365-hugenn14	251	6	plaque	plaque	NN
cord-337365-hugenn14	251	7	-	-	HYPH
cord-337365-hugenn14	251	8	enriched	enrich	VBN
cord-337365-hugenn14	251	9	areas	area	NNS
cord-337365-hugenn14	251	10	in	in	IN
cord-337365-hugenn14	251	11	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	251	12	's	's	POS
cord-337365-hugenn14	251	13	disease	disease	NN
cord-337365-hugenn14	251	14	brains	brain	NNS
cord-337365-hugenn14	251	15	[	[	-LRB-
cord-337365-hugenn14	251	16	79	79	CD
cord-337365-hugenn14	251	17	]	]	-RRB-
cord-337365-hugenn14	251	18	.	.	.
cord-337365-hugenn14	252	1	Some	some	DT
cord-337365-hugenn14	252	2	findings	finding	NNS
cord-337365-hugenn14	252	3	reveal	reveal	VBP
cord-337365-hugenn14	252	4	that	that	IN
cord-337365-hugenn14	252	5	microglia	microglia	NNS
cord-337365-hugenn14	252	6	serve	serve	VBP
cord-337365-hugenn14	252	7	as	as	IN
cord-337365-hugenn14	252	8	important	important	JJ
cord-337365-hugenn14	252	9	physiological	physiological	JJ
cord-337365-hugenn14	252	10	functions	function	NNS
cord-337365-hugenn14	252	11	in	in	IN
cord-337365-hugenn14	252	12	learning	learning	NN
cord-337365-hugenn14	252	13	and	and	CC
cord-337365-hugenn14	252	14	memory	memory	NN
cord-337365-hugenn14	252	15	by	by	IN
cord-337365-hugenn14	252	16	promoting	promote	VBG
cord-337365-hugenn14	252	17	learning	learning	NN
cord-337365-hugenn14	252	18	-	-	HYPH
cord-337365-hugenn14	252	19	related	relate	VBN
cord-337365-hugenn14	252	20	synapse	synapse	NN
cord-337365-hugenn14	252	21	formation	formation	NN
cord-337365-hugenn14	252	22	through	through	IN
cord-337365-hugenn14	252	23	brain	brain	NN
cord-337365-hugenn14	252	24	-	-	HYPH
cord-337365-hugenn14	252	25	derived	derive	VBN
cord-337365-hugenn14	252	26	neurotrophic	neurotrophic	NN
cord-337365-hugenn14	252	27	factor	factor	NN
cord-337365-hugenn14	252	28	(	(	-LRB-
cord-337365-hugenn14	252	29	BDNF	BDNF	NNP
cord-337365-hugenn14	252	30	)	)	-RRB-
cord-337365-hugenn14	252	31	signaling	signal	VBG
cord-337365-hugenn14	252	32	[	[	-LRB-
cord-337365-hugenn14	252	33	80	80	CD
cord-337365-hugenn14	252	34	]	]	-RRB-
cord-337365-hugenn14	252	35	.	.	.
cord-337365-hugenn14	253	1	In	in	IN
cord-337365-hugenn14	253	2	the	the	DT
cord-337365-hugenn14	253	3	AD	ad	NN
cord-337365-hugenn14	253	4	mouse	mouse	NN
cord-337365-hugenn14	253	5	model	model	NN
cord-337365-hugenn14	253	6	,	,	,
cord-337365-hugenn14	253	7	a	a	DT
cord-337365-hugenn14	253	8	disease	disease	NN
cord-337365-hugenn14	253	9	-	-	HYPH
cord-337365-hugenn14	253	10	associated	associate	VBN
cord-337365-hugenn14	253	11	microglia	microglia	NNP
cord-337365-hugenn14	253	12	(	(	-LRB-
cord-337365-hugenn14	253	13	DAM	DAM	NNP
cord-337365-hugenn14	253	14	)	)	-RRB-
cord-337365-hugenn14	253	15	subtype	subtype	NN
cord-337365-hugenn14	253	16	was	be	VBD
cord-337365-hugenn14	253	17	found	find	VBN
cord-337365-hugenn14	253	18	.	.	.
cord-337365-hugenn14	254	1	DAM	DAM	NNP
cord-337365-hugenn14	254	2	selectively	selectively	RB
cord-337365-hugenn14	254	3	aggregates	aggregate	VBZ
cord-337365-hugenn14	254	4	around	around	IN
cord-337365-hugenn14	254	5	Aβ	Aβ	NNP
cord-337365-hugenn14	254	6	and	and	CC
cord-337365-hugenn14	254	7	exerts	exert	VBZ
cord-337365-hugenn14	254	8	phagocytosis	phagocytosis	NN
cord-337365-hugenn14	254	9	.	.	.
cord-337365-hugenn14	255	1	Immunohistochemical	immunohistochemical	JJ
cord-337365-hugenn14	255	2	staining	staining	NN
cord-337365-hugenn14	255	3	of	of	IN
cord-337365-hugenn14	255	4	mice	mouse	NNS
cord-337365-hugenn14	255	5	and	and	CC
cord-337365-hugenn14	255	6	human	human	JJ
cord-337365-hugenn14	255	7	brain	brain	NN
cord-337365-hugenn14	255	8	slices	slice	NNS
cord-337365-hugenn14	255	9	shows	show	VBZ
cord-337365-hugenn14	255	10	DAM	dam	NN
cord-337365-hugenn14	255	11	with	with	IN
cord-337365-hugenn14	255	12	intracellular	intracellular	JJ
cord-337365-hugenn14	255	13	/	/	SYM
cord-337365-hugenn14	255	14	phagocytic	phagocytic	NN
cord-337365-hugenn14	255	15	Aβ	Aβ	NNP
cord-337365-hugenn14	255	16	particles	particle	NNS
cord-337365-hugenn14	255	17	[	[	-LRB-
cord-337365-hugenn14	255	18	81	81	CD
cord-337365-hugenn14	255	19	]	]	-RRB-
cord-337365-hugenn14	255	20	.	.	.
cord-337365-hugenn14	256	1	The	the	DT
cord-337365-hugenn14	256	2	accumulation	accumulation	NN
cord-337365-hugenn14	256	3	of	of	IN
cord-337365-hugenn14	256	4	microglia	microglia	NN
cord-337365-hugenn14	256	5	around	around	IN
cord-337365-hugenn14	256	6	the	the	DT
cord-337365-hugenn14	256	7	Aβ	Aβ	NNP
cord-337365-hugenn14	256	8	plaque	plaque	NN
cord-337365-hugenn14	256	9	is	be	VBZ
cord-337365-hugenn14	256	10	critical	critical	JJ
cord-337365-hugenn14	256	11	to	to	IN
cord-337365-hugenn14	256	12	establishing	establish	VBG
cord-337365-hugenn14	256	13	a	a	DT
cord-337365-hugenn14	256	14	physical	physical	JJ
cord-337365-hugenn14	256	15	barrier	barrier	NN
cord-337365-hugenn14	256	16	that	that	WDT
cord-337365-hugenn14	256	17	limits	limit	VBZ
cord-337365-hugenn14	256	18	the	the	DT
cord-337365-hugenn14	256	19	spread	spread	NN
cord-337365-hugenn14	256	20	of	of	IN
cord-337365-hugenn14	256	21	plaque	plaque	NN
cord-337365-hugenn14	256	22	and	and	CC
cord-337365-hugenn14	256	23	protects	protect	VBZ
cord-337365-hugenn14	256	24	surrounding	surround	VBG
cord-337365-hugenn14	256	25	neurons	neuron	NNS
cord-337365-hugenn14	256	26	from	from	IN
cord-337365-hugenn14	256	27	the	the	DT
cord-337365-hugenn14	256	28	toxic	toxic	JJ
cord-337365-hugenn14	256	29	effects	effect	NNS
cord-337365-hugenn14	256	30	of	of	IN
cord-337365-hugenn14	256	31	the	the	DT
cord-337365-hugenn14	256	32	plaque	plaque	NN
cord-337365-hugenn14	256	33	[	[	-LRB-
cord-337365-hugenn14	256	34	82	82	CD
cord-337365-hugenn14	256	35	]	]	-RRB-
cord-337365-hugenn14	256	36	.	.	.
cord-337365-hugenn14	257	1	Interestingly	interestingly	RB
cord-337365-hugenn14	257	2	,	,	,
cord-337365-hugenn14	257	3	in	in	IN
cord-337365-hugenn14	257	4	a	a	DT
cord-337365-hugenn14	257	5	mouse	mouse	NN
cord-337365-hugenn14	257	6	model	model	NN
cord-337365-hugenn14	257	7	lacking	lack	VBG
cord-337365-hugenn14	257	8	triggering	trigger	VBG
cord-337365-hugenn14	257	9	receptor	receptor	NN
cord-337365-hugenn14	257	10	expressed	express	VBN
cord-337365-hugenn14	257	11	on	on	IN
cord-337365-hugenn14	257	12	myeloid	myeloid	JJ
cord-337365-hugenn14	257	13	cells	cell	NNS
cord-337365-hugenn14	257	14	2	2	CD
cord-337365-hugenn14	257	15	(	(	-LRB-
cord-337365-hugenn14	257	16	TREM2	TREM2	NNP
cord-337365-hugenn14	257	17	)	)	-RRB-
cord-337365-hugenn14	257	18	,	,	,
cord-337365-hugenn14	257	19	microglia	microglia	NNP
cord-337365-hugenn14	257	20	could	could	MD
cord-337365-hugenn14	257	21	not	not	RB
cord-337365-hugenn14	257	22	accumulate	accumulate	VB
cord-337365-hugenn14	257	23	around	around	IN
cord-337365-hugenn14	257	24	Aβ	Aβ	NNP
cord-337365-hugenn14	257	25	and	and	CC
cord-337365-hugenn14	257	26	the	the	DT
cord-337365-hugenn14	257	27	survival	survival	NN
cord-337365-hugenn14	257	28	and	and	CC
cord-337365-hugenn14	257	29	proliferation	proliferation	NN
cord-337365-hugenn14	257	30	of	of	IN
cord-337365-hugenn14	257	31	microglia	microglia	NN
cord-337365-hugenn14	257	32	around	around	IN
cord-337365-hugenn14	257	33	the	the	DT
cord-337365-hugenn14	257	34	plaque	plaque	NN
cord-337365-hugenn14	257	35	is	be	VBZ
cord-337365-hugenn14	257	36	impaired	impair	VBN
cord-337365-hugenn14	257	37	.	.	.
cord-337365-hugenn14	258	1	At	at	IN
cord-337365-hugenn14	258	2	the	the	DT
cord-337365-hugenn14	258	3	same	same	JJ
cord-337365-hugenn14	258	4	time	time	NN
cord-337365-hugenn14	258	5	,	,	,
cord-337365-hugenn14	258	6	the	the	DT
cord-337365-hugenn14	258	7	migration	migration	NN
cord-337365-hugenn14	258	8	of	of	IN
cord-337365-hugenn14	258	9	microglia	microglia	NNP
cord-337365-hugenn14	258	10	to	to	IN
cord-337365-hugenn14	258	11	the	the	DT
cord-337365-hugenn14	258	12	lesion	lesion	NN
cord-337365-hugenn14	258	13	is	be	VBZ
cord-337365-hugenn14	258	14	impaired	impair	VBN
cord-337365-hugenn14	258	15	[	[	-LRB-
cord-337365-hugenn14	258	16	83	83	CD
cord-337365-hugenn14	258	17	,	,	,
cord-337365-hugenn14	258	18	82	82	CD
cord-337365-hugenn14	258	19	]	]	-RRB-
cord-337365-hugenn14	258	20	.	.	.
cord-337365-hugenn14	259	1	The	the	DT
cord-337365-hugenn14	259	2	microglia	microglia	NNS
cord-337365-hugenn14	259	3	lacking	lack	VBG
cord-337365-hugenn14	259	4	TREM2	TREM2	NNP
cord-337365-hugenn14	259	5	has	have	VBZ
cord-337365-hugenn14	259	6	metabolic	metabolic	JJ
cord-337365-hugenn14	259	7	disorders	disorder	NNS
cord-337365-hugenn14	259	8	,	,	,
cord-337365-hugenn14	259	9	which	which	WDT
cord-337365-hugenn14	259	10	are	be	VBP
cord-337365-hugenn14	259	11	characterized	characterize	VBN
cord-337365-hugenn14	259	12	by	by	IN
cord-337365-hugenn14	259	13	defects	defect	NNS
cord-337365-hugenn14	259	14	in	in	IN
cord-337365-hugenn14	259	15	glycolysis	glycolysis	NN
cord-337365-hugenn14	259	16	,	,	,
cord-337365-hugenn14	259	17	ATP	ATP	NNP
cord-337365-hugenn14	259	18	levels	level	NNS
cord-337365-hugenn14	259	19	,	,	,
cord-337365-hugenn14	259	20	and	and	CC
cord-337365-hugenn14	259	21	anabolism	anabolism	NN
cord-337365-hugenn14	259	22	[	[	-LRB-
cord-337365-hugenn14	259	23	83	83	CD
cord-337365-hugenn14	259	24	]	]	-RRB-
cord-337365-hugenn14	259	25	.	.	.
cord-337365-hugenn14	260	1	At	at	IN
cord-337365-hugenn14	260	2	the	the	DT
cord-337365-hugenn14	260	3	same	same	JJ
cord-337365-hugenn14	260	4	time	time	NN
cord-337365-hugenn14	260	5	,	,	,
cord-337365-hugenn14	260	6	the	the	DT
cord-337365-hugenn14	260	7	signaling	signal	VBG
cord-337365-hugenn14	260	8	pathway	pathway	NN
cord-337365-hugenn14	260	9	of	of	IN
cord-337365-hugenn14	260	10	TREM	TREM	NNP
cord-337365-hugenn14	260	11	2	2	CD
cord-337365-hugenn14	260	12	is	be	VBZ
cord-337365-hugenn14	260	13	essential	essential	JJ
cord-337365-hugenn14	260	14	for	for	IN
cord-337365-hugenn14	260	15	phagocytosis	phagocytosis	NN
cord-337365-hugenn14	260	16	of	of	IN
cord-337365-hugenn14	260	17	microglia	microglia	NN
cord-337365-hugenn14	260	18	,	,	,
cord-337365-hugenn14	260	19	and	and	CC
cord-337365-hugenn14	260	20	the	the	DT
cord-337365-hugenn14	260	21	deletion	deletion	NN
cord-337365-hugenn14	260	22	of	of	IN
cord-337365-hugenn14	260	23	TREM	TREM	NNP
cord-337365-hugenn14	260	24	2	2	CD
cord-337365-hugenn14	260	25	leads	lead	VBZ
cord-337365-hugenn14	260	26	to	to	IN
cord-337365-hugenn14	260	27	aggravated	aggravate	VBN
cord-337365-hugenn14	260	28	pathology	pathology	NN
cord-337365-hugenn14	260	29	[	[	-LRB-
cord-337365-hugenn14	260	30	84	84	CD
cord-337365-hugenn14	260	31	]	]	-RRB-
cord-337365-hugenn14	260	32	.	.	.
cord-337365-hugenn14	261	1	More	more	RBR
cord-337365-hugenn14	261	2	malnourished	malnourished	JJ
cord-337365-hugenn14	261	3	neurons	neuron	NNS
cord-337365-hugenn14	261	4	were	be	VBD
cord-337365-hugenn14	261	5	observed	observe	VBN
cord-337365-hugenn14	261	6	in	in	IN
cord-337365-hugenn14	261	7	the	the	DT
cord-337365-hugenn14	261	8	brain	brain	NN
cord-337365-hugenn14	261	9	sections	section	NNS
cord-337365-hugenn14	261	10	in	in	IN
cord-337365-hugenn14	261	11	patients	patient	NNS
cord-337365-hugenn14	261	12	carrying	carry	VBG
cord-337365-hugenn14	261	13	AD	ad	NN
cord-337365-hugenn14	261	14	-	-	HYPH
cord-337365-hugenn14	261	15	associated	associate	VBN
cord-337365-hugenn14	261	16	TREM2	TREM2	NNP
cord-337365-hugenn14	261	17	variants	variant	NNS
cord-337365-hugenn14	261	18	[	[	-LRB-
cord-337365-hugenn14	261	19	85	85	CD
cord-337365-hugenn14	261	20	]	]	-RRB-
cord-337365-hugenn14	261	21	.	.	.
cord-337365-hugenn14	262	1	In	in	IN
cord-337365-hugenn14	262	2	contrast	contrast	NN
cord-337365-hugenn14	262	3	,	,	,
cord-337365-hugenn14	262	4	it	-PRON-	PRP
cord-337365-hugenn14	262	5	has	have	VBZ
cord-337365-hugenn14	262	6	been	be	VBN
cord-337365-hugenn14	262	7	reported	report	VBN
cord-337365-hugenn14	262	8	that	that	IN
cord-337365-hugenn14	262	9	when	when	WRB
cord-337365-hugenn14	262	10	microglia	microglia	NNP
cord-337365-hugenn14	262	11	respond	respond	VBP
cord-337365-hugenn14	262	12	to	to	IN
cord-337365-hugenn14	262	13	Aβ	Aβ	NNP
cord-337365-hugenn14	262	14	plaques	plaque	NNS
cord-337365-hugenn14	262	15	,	,	,
cord-337365-hugenn14	262	16	it	-PRON-	PRP
cord-337365-hugenn14	262	17	activates	activate	VBZ
cord-337365-hugenn14	262	18	inflammatory	inflammatory	JJ
cord-337365-hugenn14	262	19	bodies	body	NNS
cord-337365-hugenn14	262	20	,	,	,
cord-337365-hugenn14	262	21	leading	lead	VBG
cord-337365-hugenn14	262	22	to	to	IN
cord-337365-hugenn14	262	23	the	the	DT
cord-337365-hugenn14	262	24	escalation	escalation	NN
cord-337365-hugenn14	262	25	of	of	IN
cord-337365-hugenn14	262	26	inflammation	inflammation	NN
cord-337365-hugenn14	262	27	and	and	CC
cord-337365-hugenn14	262	28	the	the	DT
cord-337365-hugenn14	262	29	release	release	NN
cord-337365-hugenn14	262	30	of	of	IN
cord-337365-hugenn14	262	31	apoptosis	apoptosis	NN
cord-337365-hugenn14	262	32	-	-	HYPH
cord-337365-hugenn14	262	33	associated	associate	VBN
cord-337365-hugenn14	262	34	speck	speck	NN
cord-337365-hugenn14	262	35	-	-	HYPH
cord-337365-hugenn14	262	36	like	like	JJ
cord-337365-hugenn14	262	37	protein	protein	NN
cord-337365-hugenn14	262	38	containing	contain	VBG
cord-337365-hugenn14	262	39	a	a	DT
cord-337365-hugenn14	262	40	CARD	card	NN
cord-337365-hugenn14	262	41	(	(	-LRB-
cord-337365-hugenn14	262	42	ASC	ASC	NNP
cord-337365-hugenn14	262	43	)	)	-RRB-
cord-337365-hugenn14	262	44	specks	speck	NNS
cord-337365-hugenn14	262	45	from	from	IN
cord-337365-hugenn14	262	46	inflammasomes	inflammasome	NNS
cord-337365-hugenn14	262	47	,	,	,
cord-337365-hugenn14	262	48	which	which	WDT
cord-337365-hugenn14	262	49	in	in	IN
cord-337365-hugenn14	262	50	turn	turn	NN
cord-337365-hugenn14	262	51	may	may	MD
cord-337365-hugenn14	262	52	initiate	initiate	VB
cord-337365-hugenn14	262	53	the	the	DT
cord-337365-hugenn14	262	54	seeding	seeding	NN
cord-337365-hugenn14	262	55	of	of	IN
cord-337365-hugenn14	262	56	new	new	JJ
cord-337365-hugenn14	262	57	plaques	plaque	NNS
cord-337365-hugenn14	262	58	[	[	-LRB-
cord-337365-hugenn14	262	59	86	86	CD
cord-337365-hugenn14	262	60	]	]	-RRB-
cord-337365-hugenn14	262	61	.	.	.
cord-337365-hugenn14	263	1	Moreover	moreover	RB
cord-337365-hugenn14	263	2	,	,	,
cord-337365-hugenn14	263	3	excessive	excessive	JJ
cord-337365-hugenn14	263	4	activation	activation	NN
cord-337365-hugenn14	263	5	of	of	IN
cord-337365-hugenn14	263	6	microglia	microglia	NNS
cord-337365-hugenn14	263	7	in	in	IN
cord-337365-hugenn14	263	8	the	the	DT
cord-337365-hugenn14	263	9	early	early	JJ
cord-337365-hugenn14	263	10	stages	stage	NNS
cord-337365-hugenn14	263	11	of	of	IN
cord-337365-hugenn14	263	12	AD	ad	NN
cord-337365-hugenn14	263	13	may	may	MD
cord-337365-hugenn14	263	14	cause	cause	VB
cord-337365-hugenn14	263	15	excessive	excessive	JJ
cord-337365-hugenn14	263	16	synaptic	synaptic	JJ
cord-337365-hugenn14	263	17	pruning	pruning	NN
cord-337365-hugenn14	263	18	,	,	,
cord-337365-hugenn14	263	19	leading	lead	VBG
cord-337365-hugenn14	263	20	to	to	IN
cord-337365-hugenn14	263	21	cognitive	cognitive	JJ
cord-337365-hugenn14	263	22	impairment	impairment	NN
cord-337365-hugenn14	263	23	[	[	-LRB-
cord-337365-hugenn14	263	24	87	87	CD
cord-337365-hugenn14	263	25	]	]	-RRB-
cord-337365-hugenn14	263	26	.	.	.
cord-337365-hugenn14	264	1	In	in	IN
cord-337365-hugenn14	264	2	summary	summary	NN
cord-337365-hugenn14	264	3	,	,	,
cord-337365-hugenn14	264	4	HSV-1	hsv-1	NN
cord-337365-hugenn14	264	5	infection	infection	NN
cord-337365-hugenn14	264	6	accelerates	accelerate	VBZ
cord-337365-hugenn14	264	7	the	the	DT
cord-337365-hugenn14	264	8	deposition	deposition	NN
cord-337365-hugenn14	264	9	of	of	IN
cord-337365-hugenn14	264	10	Aβ	Aβ	NNP
cord-337365-hugenn14	264	11	in	in	IN
cord-337365-hugenn14	264	12	the	the	DT
cord-337365-hugenn14	264	13	brain	brain	NN
cord-337365-hugenn14	264	14	and	and	CC
cord-337365-hugenn14	264	15	activates	activate	VBZ
cord-337365-hugenn14	264	16	microglia	microglia	NNS
cord-337365-hugenn14	264	17	.	.	.
cord-337365-hugenn14	265	1	And	and	CC
cord-337365-hugenn14	265	2	the	the	DT
cord-337365-hugenn14	265	3	role	role	NN
cord-337365-hugenn14	265	4	of	of	IN
cord-337365-hugenn14	265	5	Aβ	Aβ	NNP
cord-337365-hugenn14	265	6	during	during	IN
cord-337365-hugenn14	265	7	viral	viral	JJ
cord-337365-hugenn14	265	8	encephalitis	encephalitis	NN
cord-337365-hugenn14	265	9	remains	remain	VBZ
cord-337365-hugenn14	265	10	obscure	obscure	JJ
cord-337365-hugenn14	265	11	and	and	CC
cord-337365-hugenn14	265	12	requires	require	VBZ
cord-337365-hugenn14	265	13	additional	additional	JJ
cord-337365-hugenn14	265	14	study	study	NN
cord-337365-hugenn14	265	15	.	.	.
cord-337365-hugenn14	266	1	Necroptosis	Necroptosis	NNP
cord-337365-hugenn14	266	2	is	be	VBZ
cord-337365-hugenn14	266	3	a	a	DT
cord-337365-hugenn14	266	4	programmed	programmed	JJ
cord-337365-hugenn14	266	5	cell	cell	NN
cord-337365-hugenn14	266	6	death	death	NN
cord-337365-hugenn14	266	7	coordinated	coordinate	VBN
cord-337365-hugenn14	266	8	by	by	IN
cord-337365-hugenn14	266	9	receptor	receptor	NN
cord-337365-hugenn14	266	10	-	-	HYPH
cord-337365-hugenn14	266	11	interacting	interact	VBG
cord-337365-hugenn14	266	12	protein	protein	NN
cord-337365-hugenn14	266	13	kinases	kinase	NNS
cord-337365-hugenn14	266	14	1	1	CD
cord-337365-hugenn14	266	15	(	(	-LRB-
cord-337365-hugenn14	266	16	RIPK1	RIPK1	NNP
cord-337365-hugenn14	266	17	)	)	-RRB-
cord-337365-hugenn14	266	18	and	and	CC
cord-337365-hugenn14	266	19	3	3	LS
cord-337365-hugenn14	266	20	(	(	-LRB-
cord-337365-hugenn14	266	21	RIPK3	RIPK3	NNP
cord-337365-hugenn14	266	22	)	)	-RRB-
cord-337365-hugenn14	266	23	.	.	.
cord-337365-hugenn14	267	1	Mixed	mixed	JJ
cord-337365-hugenn14	267	2	lineage	lineage	NN
cord-337365-hugenn14	267	3	kinase	kinase	VBZ
cord-337365-hugenn14	267	4	domain	domain	NN
cord-337365-hugenn14	267	5	-	-	HYPH
cord-337365-hugenn14	267	6	like	like	JJ
cord-337365-hugenn14	267	7	protein	protein	NN
cord-337365-hugenn14	267	8	(	(	-LRB-
cord-337365-hugenn14	267	9	MLKL	MLKL	NNP
cord-337365-hugenn14	267	10	)	)	-RRB-
cord-337365-hugenn14	267	11	is	be	VBZ
cord-337365-hugenn14	267	12	an	an	DT
cord-337365-hugenn14	267	13	executioner	executioner	NN
cord-337365-hugenn14	267	14	protein	protein	NN
cord-337365-hugenn14	267	15	that	that	WDT
cord-337365-hugenn14	267	16	participates	participate	VBZ
cord-337365-hugenn14	267	17	in	in	IN
cord-337365-hugenn14	267	18	the	the	DT
cord-337365-hugenn14	267	19	formation	formation	NN
cord-337365-hugenn14	267	20	of	of	IN
cord-337365-hugenn14	267	21	an	an	DT
cord-337365-hugenn14	267	22	apoptotic	apoptotic	JJ
cord-337365-hugenn14	267	23	complex	complex	NN
cord-337365-hugenn14	267	24	that	that	WDT
cord-337365-hugenn14	267	25	promotes	promote	VBZ
cord-337365-hugenn14	267	26	cell	cell	NN
cord-337365-hugenn14	267	27	death	death	NN
cord-337365-hugenn14	267	28	through	through	IN
cord-337365-hugenn14	267	29	cell	cell	NN
cord-337365-hugenn14	267	30	membrane	membrane	NN
cord-337365-hugenn14	267	31	disruption	disruption	NN
cord-337365-hugenn14	267	32	and	and	CC
cord-337365-hugenn14	267	33	cell	cell	NN
cord-337365-hugenn14	267	34	rupture	rupture	NN
cord-337365-hugenn14	267	35	[	[	-LRB-
cord-337365-hugenn14	267	36	88	88	CD
cord-337365-hugenn14	267	37	]	]	-RRB-
cord-337365-hugenn14	267	38	.	.	.
cord-337365-hugenn14	268	1	Studies	study	NNS
cord-337365-hugenn14	268	2	have	have	VBP
cord-337365-hugenn14	268	3	shown	show	VBN
cord-337365-hugenn14	268	4	that	that	IN
cord-337365-hugenn14	268	5	the	the	DT
cord-337365-hugenn14	268	6	RIPK3	ripk3	NN
cord-337365-hugenn14	268	7	signaling	signal	VBG
cord-337365-hugenn14	268	8	pathway	pathway	NN
cord-337365-hugenn14	268	9	can	can	MD
cord-337365-hugenn14	268	10	control	control	VB
cord-337365-hugenn14	268	11	a	a	DT
cord-337365-hugenn14	268	12	variety	variety	NN
cord-337365-hugenn14	268	13	of	of	IN
cord-337365-hugenn14	268	14	viral	viral	JJ
cord-337365-hugenn14	268	15	infections	infection	NNS
cord-337365-hugenn14	268	16	,	,	,
cord-337365-hugenn14	268	17	including	include	VBG
cord-337365-hugenn14	268	18	HSV-1	hsv-1	NN
cord-337365-hugenn14	268	19	.	.	.
cord-337365-hugenn14	269	1	Murine	murine	JJ
cord-337365-hugenn14	269	2	but	but	CC
cord-337365-hugenn14	269	3	not	not	RB
cord-337365-hugenn14	269	4	human	human	JJ
cord-337365-hugenn14	269	5	RIP1/	RIP1/	NNP
cord-337365-hugenn14	269	6	RIP3	RIP3	NNPS
cord-337365-hugenn14	269	7	directly	directly	RB
cord-337365-hugenn14	269	8	senses	sense	VBZ
cord-337365-hugenn14	269	9	HSV-1	hsv-1	VBP
cord-337365-hugenn14	269	10	ICP6	ICP6	NNP
cord-337365-hugenn14	269	11	to	to	TO
cord-337365-hugenn14	269	12	initiate	initiate	VB
cord-337365-hugenn14	269	13	necroptosis	necroptosis	NNP
cord-337365-hugenn14	269	14	[	[	-LRB-
cord-337365-hugenn14	269	15	89	89	CD
cord-337365-hugenn14	269	16	]	]	-RRB-
cord-337365-hugenn14	269	17	.	.	.
cord-337365-hugenn14	270	1	In	in	IN
cord-337365-hugenn14	270	2	the	the	DT
cord-337365-hugenn14	270	3	WNV	WNV	NNP
cord-337365-hugenn14	270	4	virus	virus	NN
cord-337365-hugenn14	270	5	infection	infection	NN
cord-337365-hugenn14	270	6	model	model	NN
cord-337365-hugenn14	270	7	,	,	,
cord-337365-hugenn14	270	8	it	-PRON-	PRP
cord-337365-hugenn14	270	9	was	be	VBD
cord-337365-hugenn14	270	10	found	find	VBN
cord-337365-hugenn14	270	11	that	that	IN
cord-337365-hugenn14	270	12	RIPK	RIPK	NNP
cord-337365-hugenn14	270	13	3	3	CD
cord-337365-hugenn14	270	14	inhibits	inhibit	VBZ
cord-337365-hugenn14	270	15	viral	viral	JJ
cord-337365-hugenn14	270	16	pathogenesis	pathogenesis	NN
cord-337365-hugenn14	270	17	by	by	IN
cord-337365-hugenn14	270	18	cell	cell	NN
cord-337365-hugenn14	270	19	death	death	NN
cord-337365-hugenn14	270	20	-	-	HYPH
cord-337365-hugenn14	270	21	independent	independent	JJ
cord-337365-hugenn14	270	22	neuroinflammation	neuroinflammation	NN
cord-337365-hugenn14	270	23	,	,	,
cord-337365-hugenn14	270	24	mice	mouse	NNS
cord-337365-hugenn14	270	25	lacking	lack	VBG
cord-337365-hugenn14	270	26	RIPK	RIPK	NNP
cord-337365-hugenn14	270	27	3	3	CD
cord-337365-hugenn14	270	28	,	,	,
cord-337365-hugenn14	270	29	or	or	CC
cord-337365-hugenn14	270	30	RIPK	ripk	NN
cord-337365-hugenn14	270	31	1	1	CD
cord-337365-hugenn14	270	32	kinase	kinase	NN
cord-337365-hugenn14	270	33	activity	activity	NN
cord-337365-hugenn14	270	34	,	,	,
cord-337365-hugenn14	270	35	but	but	CC
cord-337365-hugenn14	270	36	not	not	RB
cord-337365-hugenn14	270	37	those	those	DT
cord-337365-hugenn14	270	38	lacking	lack	VBG
cord-337365-hugenn14	270	39	mlkl	mlkl	NN
cord-337365-hugenn14	270	40	or	or	CC
cord-337365-hugenn14	270	41	mlkl	mlkl	NN
cord-337365-hugenn14	270	42	,	,	,
cord-337365-hugenn14	270	43	and	and	CC
cord-337365-hugenn14	270	44	caspase-8	caspase-8	NNP
cord-337365-hugenn14	270	45	increased	increase	VBN
cord-337365-hugenn14	270	46	susceptibility	susceptibility	NN
cord-337365-hugenn14	270	47	to	to	IN
cord-337365-hugenn14	270	48	lethal	lethal	JJ
cord-337365-hugenn14	270	49	WNV	WNV	NNP
cord-337365-hugenn14	270	50	infection	infection	NN
cord-337365-hugenn14	270	51	.	.	.
cord-337365-hugenn14	271	1	During	during	IN
cord-337365-hugenn14	271	2	WNV	WNV	NNP
cord-337365-hugenn14	271	3	infection	infection	NN
cord-337365-hugenn14	271	4	of	of	IN
cord-337365-hugenn14	271	5	neurons	neuron	NNS
cord-337365-hugenn14	271	6	,	,	,
cord-337365-hugenn14	271	7	RIPK3	RIPK3	NNP
cord-337365-hugenn14	271	8	is	be	VBZ
cord-337365-hugenn14	271	9	activated	activate	VBN
cord-337365-hugenn14	271	10	in	in	IN
cord-337365-hugenn14	271	11	neurons	neuron	NNS
cord-337365-hugenn14	271	12	which	which	WDT
cord-337365-hugenn14	271	13	promotes	promote	VBZ
cord-337365-hugenn14	271	14	the	the	DT
cord-337365-hugenn14	271	15	expression	expression	NN
cord-337365-hugenn14	271	16	of	of	IN
cord-337365-hugenn14	271	17	chemokines	chemokine	NNS
cord-337365-hugenn14	271	18	CCL2	CCL2	NNP
cord-337365-hugenn14	271	19	,	,	,
cord-337365-hugenn14	271	20	CXCL10	CXCL10	NNP
cord-337365-hugenn14	271	21	,	,	,
cord-337365-hugenn14	271	22	etc	etc	FW
cord-337365-hugenn14	271	23	.	.	.
cord-337365-hugenn14	272	1	and	and	CC
cord-337365-hugenn14	272	2	recruits	recruit	VBZ
cord-337365-hugenn14	272	3	infiltration	infiltration	NN
cord-337365-hugenn14	272	4	of	of	IN
cord-337365-hugenn14	272	5	immune	immune	JJ
cord-337365-hugenn14	272	6	cells	cell	NNS
cord-337365-hugenn14	272	7	including	include	VBG
cord-337365-hugenn14	272	8	T	t	NN
cord-337365-hugenn14	272	9	cells	cell	NNS
cord-337365-hugenn14	272	10	,	,	,
cord-337365-hugenn14	272	11	mononuclear	mononuclear	JJ
cord-337365-hugenn14	272	12	macrophages	macrophage	NNS
cord-337365-hugenn14	272	13	,	,	,
cord-337365-hugenn14	272	14	and	and	CC
cord-337365-hugenn14	272	15	antigen	antigen	NN
cord-337365-hugenn14	272	16	presenting	present	VBG
cord-337365-hugenn14	272	17	cells	cell	NNS
cord-337365-hugenn14	272	18	which	which	WDT
cord-337365-hugenn14	272	19	exert	exert	VBP
cord-337365-hugenn14	272	20	antiviral	antiviral	JJ
cord-337365-hugenn14	272	21	effects	effect	NNS
cord-337365-hugenn14	272	22	.	.	.
cord-337365-hugenn14	273	1	This	this	DT
cord-337365-hugenn14	273	2	process	process	NN
cord-337365-hugenn14	273	3	does	do	VBZ
cord-337365-hugenn14	273	4	not	not	RB
cord-337365-hugenn14	273	5	affect	affect	VB
cord-337365-hugenn14	273	6	the	the	DT
cord-337365-hugenn14	273	7	number	number	NN
cord-337365-hugenn14	273	8	of	of	IN
cord-337365-hugenn14	273	9	microglia	microglia	NNS
cord-337365-hugenn14	273	10	in	in	IN
cord-337365-hugenn14	273	11	CNS	CNS	NNP
cord-337365-hugenn14	273	12	[	[	-LRB-
cord-337365-hugenn14	273	13	90	90	CD
cord-337365-hugenn14	273	14	]	]	-RRB-
cord-337365-hugenn14	273	15	.	.	.
cord-337365-hugenn14	274	1	What	what	WDT
cord-337365-hugenn14	274	2	role	role	NN
cord-337365-hugenn14	274	3	does	do	VBZ
cord-337365-hugenn14	274	4	the	the	DT
cord-337365-hugenn14	274	5	RIPK3	ripk3	NN
cord-337365-hugenn14	274	6	signaling	signal	VBG
cord-337365-hugenn14	274	7	pathway	pathway	NN
cord-337365-hugenn14	274	8	in	in	IN
cord-337365-hugenn14	274	9	microglia	microglia	JJ
cord-337365-hugenn14	274	10	play	play	VBP
cord-337365-hugenn14	274	11	in	in	IN
cord-337365-hugenn14	274	12	viral	viral	JJ
cord-337365-hugenn14	274	13	encephalitis	encephalitis	RB
cord-337365-hugenn14	274	14	?	?	.
cord-337365-hugenn14	275	1	Further	further	JJ
cord-337365-hugenn14	275	2	exploration	exploration	NN
cord-337365-hugenn14	275	3	is	be	VBZ
cord-337365-hugenn14	275	4	needed	need	VBN
cord-337365-hugenn14	275	5	.	.	.
cord-337365-hugenn14	276	1	Most	Most	JJS
cord-337365-hugenn14	276	2	of	of	IN
cord-337365-hugenn14	276	3	the	the	DT
cord-337365-hugenn14	276	4	experiments	experiment	NNS
cord-337365-hugenn14	276	5	on	on	IN
cord-337365-hugenn14	276	6	microglia	microglia	NN
cord-337365-hugenn14	276	7	and	and	CC
cord-337365-hugenn14	276	8	viral	viral	JJ
cord-337365-hugenn14	276	9	encephalitis	encephaliti	NNS
cord-337365-hugenn14	276	10	remain	remain	VBP
cord-337365-hugenn14	276	11	in	in	IN
cord-337365-hugenn14	276	12	the	the	DT
cord-337365-hugenn14	276	13	experimental	experimental	JJ
cord-337365-hugenn14	276	14	stage	stage	NN
cord-337365-hugenn14	276	15	,	,	,
cord-337365-hugenn14	276	16	and	and	CC
cord-337365-hugenn14	276	17	many	many	JJ
cord-337365-hugenn14	276	18	mechanisms	mechanism	NNS
cord-337365-hugenn14	276	19	need	need	VBP
cord-337365-hugenn14	276	20	to	to	TO
cord-337365-hugenn14	276	21	be	be	VB
cord-337365-hugenn14	276	22	further	further	RB
cord-337365-hugenn14	276	23	explored	explore	VBN
cord-337365-hugenn14	276	24	before	before	IN
cord-337365-hugenn14	276	25	being	be	VBG
cord-337365-hugenn14	276	26	applied	apply	VBN
cord-337365-hugenn14	276	27	to	to	IN
cord-337365-hugenn14	276	28	the	the	DT
cord-337365-hugenn14	276	29	clinic	clinic	NN
cord-337365-hugenn14	276	30	.	.	.
cord-337365-hugenn14	277	1	Although	although	IN
cord-337365-hugenn14	277	2	microglia	microglia	NNS
cord-337365-hugenn14	277	3	can	can	MD
cord-337365-hugenn14	277	4	recognize	recognize	VB
cord-337365-hugenn14	277	5	ATP	ATP	NNP
cord-337365-hugenn14	277	6	released	release	VBN
cord-337365-hugenn14	277	7	by	by	IN
cord-337365-hugenn14	277	8	infected	infected	JJ
cord-337365-hugenn14	277	9	neurons	neuron	NNS
cord-337365-hugenn14	277	10	through	through	IN
cord-337365-hugenn14	277	11	P2Y12	P2Y12	NNS
cord-337365-hugenn14	277	12	and	and	CC
cord-337365-hugenn14	277	13	are	be	VBP
cord-337365-hugenn14	277	14	recruited	recruit	VBN
cord-337365-hugenn14	277	15	around	around	IN
cord-337365-hugenn14	277	16	neurons	neuron	NNS
cord-337365-hugenn14	277	17	,	,	,
cord-337365-hugenn14	277	18	whether	whether	IN
cord-337365-hugenn14	277	19	there	there	EX
cord-337365-hugenn14	277	20	are	be	VBP
cord-337365-hugenn14	277	21	more	more	RBR
cord-337365-hugenn14	277	22	other	other	JJ
cord-337365-hugenn14	277	23	potent	potent	JJ
cord-337365-hugenn14	277	24	chemokines	chemokine	NNS
cord-337365-hugenn14	277	25	,	,	,
cord-337365-hugenn14	277	26	further	further	JJ
cord-337365-hugenn14	277	27	exploration	exploration	NN
cord-337365-hugenn14	277	28	is	be	VBZ
cord-337365-hugenn14	277	29	needed	need	VBN
cord-337365-hugenn14	277	30	.	.	.
cord-337365-hugenn14	278	1	Although	although	IN
cord-337365-hugenn14	278	2	IFN-1	IFN-1	NNP
cord-337365-hugenn14	278	3	plays	play	VBZ
cord-337365-hugenn14	278	4	an	an	DT
cord-337365-hugenn14	278	5	antiviral	antiviral	JJ
cord-337365-hugenn14	278	6	role	role	NN
cord-337365-hugenn14	278	7	in	in	IN
cord-337365-hugenn14	278	8	most	most	RBS
cord-337365-hugenn14	278	9	encephalitis	encephalitis	JJ
cord-337365-hugenn14	278	10	,	,	,
cord-337365-hugenn14	278	11	the	the	DT
cord-337365-hugenn14	278	12	optimal	optimal	JJ
cord-337365-hugenn14	278	13	IFN-1	IFN-1	NNP
cord-337365-hugenn14	278	14	concentration	concentration	NN
cord-337365-hugenn14	278	15	and	and	CC
cord-337365-hugenn14	278	16	optimal	optimal	JJ
cord-337365-hugenn14	278	17	application	application	NN
cord-337365-hugenn14	278	18	time	time	NN
cord-337365-hugenn14	278	19	are	be	VBP
cord-337365-hugenn14	278	20	still	still	RB
cord-337365-hugenn14	278	21	undetermined	undetermined	JJ
cord-337365-hugenn14	278	22	.	.	.
cord-337365-hugenn14	279	1	Microglia	Microglia	NNP
cord-337365-hugenn14	279	2	can	can	MD
cord-337365-hugenn14	279	3	induce	induce	VB
cord-337365-hugenn14	279	4	autophagy	autophagy	NN
cord-337365-hugenn14	279	5	to	to	TO
cord-337365-hugenn14	279	6	exert	exert	VB
cord-337365-hugenn14	279	7	antiviral	antiviral	JJ
cord-337365-hugenn14	279	8	effects	effect	NNS
cord-337365-hugenn14	279	9	,	,	,
cord-337365-hugenn14	279	10	but	but	CC
cord-337365-hugenn14	279	11	there	there	EX
cord-337365-hugenn14	279	12	is	be	VBZ
cord-337365-hugenn14	279	13	insufficient	insufficient	JJ
cord-337365-hugenn14	279	14	evidence	evidence	NN
cord-337365-hugenn14	279	15	.	.	.
cord-337365-hugenn14	280	1	Microglia	Microglia	NNP
cord-337365-hugenn14	280	2	produce	produce	VBP
cord-337365-hugenn14	280	3	inflammatory	inflammatory	JJ
cord-337365-hugenn14	280	4	and	and	CC
cord-337365-hugenn14	280	5	chemokines	chemokine	NNS
cord-337365-hugenn14	280	6	and	and	CC
cord-337365-hugenn14	280	7	induce	induce	VB
cord-337365-hugenn14	280	8	adaptive	adaptive	JJ
cord-337365-hugenn14	280	9	immune	immune	JJ
cord-337365-hugenn14	280	10	responses	response	NNS
cord-337365-hugenn14	280	11	.	.	.
cord-337365-hugenn14	281	1	Microglia	Microglia	NNP
cord-337365-hugenn14	281	2	resident	resident	NN
cord-337365-hugenn14	281	3	in	in	IN
cord-337365-hugenn14	281	4	different	different	JJ
cord-337365-hugenn14	281	5	brain	brain	NN
cord-337365-hugenn14	281	6	regions	region	NNS
cord-337365-hugenn14	281	7	have	have	VBP
cord-337365-hugenn14	281	8	specific	specific	JJ
cord-337365-hugenn14	281	9	gene	gene	NN
cord-337365-hugenn14	281	10	expression	expression	NN
cord-337365-hugenn14	281	11	profiles	profile	NNS
cord-337365-hugenn14	281	12	,	,	,
cord-337365-hugenn14	281	13	and	and	CC
cord-337365-hugenn14	281	14	different	different	JJ
cord-337365-hugenn14	281	15	brain	brain	NN
cord-337365-hugenn14	281	16	regions	region	NNS
cord-337365-hugenn14	281	17	have	have	VBP
cord-337365-hugenn14	281	18	different	different	JJ
cord-337365-hugenn14	281	19	susceptibility	susceptibility	NN
cord-337365-hugenn14	281	20	to	to	IN
cord-337365-hugenn14	281	21	viruses	virus	NNS
cord-337365-hugenn14	281	22	.	.	.
cord-337365-hugenn14	282	1	The	the	DT
cord-337365-hugenn14	282	2	relationship	relationship	NN
cord-337365-hugenn14	282	3	between	between	IN
cord-337365-hugenn14	282	4	the	the	DT
cord-337365-hugenn14	282	5	two	two	CD
cord-337365-hugenn14	282	6	remains	remain	NNS
cord-337365-hugenn14	282	7	undetermined	undetermined	JJ
cord-337365-hugenn14	282	8	,	,	,
cord-337365-hugenn14	282	9	and	and	CC
cord-337365-hugenn14	282	10	it	-PRON-	PRP
cord-337365-hugenn14	282	11	is	be	VBZ
cord-337365-hugenn14	282	12	expected	expect	VBN
cord-337365-hugenn14	282	13	that	that	IN
cord-337365-hugenn14	282	14	the	the	DT
cord-337365-hugenn14	282	15	innate	innate	JJ
cord-337365-hugenn14	282	16	immune	immune	JJ
cord-337365-hugenn14	282	17	response	response	NN
cord-337365-hugenn14	282	18	to	to	IN
cord-337365-hugenn14	282	19	the	the	DT
cord-337365-hugenn14	282	20	virus	virus	NN
cord-337365-hugenn14	282	21	will	will	MD
cord-337365-hugenn14	282	22	be	be	VB
cord-337365-hugenn14	282	23	enhanced	enhance	VBN
cord-337365-hugenn14	282	24	by	by	IN
cord-337365-hugenn14	282	25	changing	change	VBG
cord-337365-hugenn14	282	26	the	the	DT
cord-337365-hugenn14	282	27	gene	gene	NN
cord-337365-hugenn14	282	28	expression	expression	NN
cord-337365-hugenn14	282	29	profile	profile	NN
cord-337365-hugenn14	282	30	of	of	IN
cord-337365-hugenn14	282	31	microglia	microglia	NNP
cord-337365-hugenn14	282	32	in	in	IN
cord-337365-hugenn14	282	33	the	the	DT
cord-337365-hugenn14	282	34	future	future	NN
cord-337365-hugenn14	282	35	.	.	.
cord-337365-hugenn14	283	1	In	in	IN
cord-337365-hugenn14	283	2	WNV	WNV	NNP
cord-337365-hugenn14	283	3	infection	infection	NN
cord-337365-hugenn14	283	4	,	,	,
cord-337365-hugenn14	283	5	microglia	microglia	NNS
cord-337365-hugenn14	283	6	mediate	mediate	VBP
cord-337365-hugenn14	283	7	presynaptic	presynaptic	JJ
cord-337365-hugenn14	283	8	terminal	terminal	NN
cord-337365-hugenn14	283	9	loss	loss	NN
cord-337365-hugenn14	283	10	in	in	IN
cord-337365-hugenn14	283	11	the	the	DT
cord-337365-hugenn14	283	12	hippocampus	hippocampus	NN
cord-337365-hugenn14	283	13	though	though	IN
cord-337365-hugenn14	283	14	recognizing	recognize	VBG
cord-337365-hugenn14	283	15	C3	C3	NNP
cord-337365-hugenn14	283	16	by	by	IN
cord-337365-hugenn14	283	17	C3R	C3R	NNP
cord-337365-hugenn14	283	18	,	,	,
cord-337365-hugenn14	283	19	C3	C3	NNP
cord-337365-hugenn14	283	20	,	,	,
cord-337365-hugenn14	283	21	or	or	CC
cord-337365-hugenn14	283	22	C3R	c3r	NN
cord-337365-hugenn14	283	23	-	-	HYPH
cord-337365-hugenn14	283	24	specific	specific	JJ
cord-337365-hugenn14	283	25	antibodies	antibody	NNS
cord-337365-hugenn14	283	26	may	may	MD
cord-337365-hugenn14	283	27	block	block	VB
cord-337365-hugenn14	283	28	this	this	DT
cord-337365-hugenn14	283	29	process	process	NN
cord-337365-hugenn14	283	30	.	.	.
cord-337365-hugenn14	284	1	Microglia	Microglia	NNP
cord-337365-hugenn14	284	2	inhibit	inhibit	VBP
cord-337365-hugenn14	284	3	autophagy	autophagy	NN
cord-337365-hugenn14	284	4	in	in	IN
cord-337365-hugenn14	284	5	patients	patient	NNS
cord-337365-hugenn14	284	6	with	with	IN
cord-337365-hugenn14	284	7	HIVE	HIVE	NNP
cord-337365-hugenn14	284	8	,	,	,
cord-337365-hugenn14	284	9	aggravating	aggravate	VBG
cord-337365-hugenn14	284	10	CNS	CNS	NNP
cord-337365-hugenn14	284	11	injury	injury	NN
cord-337365-hugenn14	284	12	.	.	.
cord-337365-hugenn14	285	1	How	how	WRB
cord-337365-hugenn14	285	2	to	to	TO
cord-337365-hugenn14	285	3	inhibit	inhibit	VB
cord-337365-hugenn14	285	4	or	or	CC
cord-337365-hugenn14	285	5	delete	delete	VB
cord-337365-hugenn14	285	6	the	the	DT
cord-337365-hugenn14	285	7	function	function	NN
cord-337365-hugenn14	285	8	of	of	IN
cord-337365-hugenn14	285	9	microglia	microglia	NN
cord-337365-hugenn14	285	10	or	or	CC
cord-337365-hugenn14	285	11	how	how	WRB
cord-337365-hugenn14	285	12	to	to	TO
cord-337365-hugenn14	285	13	enhance	enhance	VB
cord-337365-hugenn14	285	14	the	the	DT
cord-337365-hugenn14	285	15	autophagy	autophagy	NN
cord-337365-hugenn14	285	16	of	of	IN
cord-337365-hugenn14	285	17	neurons	neuron	NNS
cord-337365-hugenn14	285	18	will	will	MD
cord-337365-hugenn14	285	19	become	become	VB
cord-337365-hugenn14	285	20	the	the	DT
cord-337365-hugenn14	285	21	direction	direction	NN
cord-337365-hugenn14	285	22	of	of	IN
cord-337365-hugenn14	285	23	future	future	JJ
cord-337365-hugenn14	285	24	research	research	NN
cord-337365-hugenn14	285	25	.	.	.
cord-337365-hugenn14	286	1	There	there	EX
cord-337365-hugenn14	286	2	is	be	VBZ
cord-337365-hugenn14	286	3	a	a	DT
cord-337365-hugenn14	286	4	strong	strong	JJ
cord-337365-hugenn14	286	5	relationship	relationship	NN
cord-337365-hugenn14	286	6	between	between	IN
cord-337365-hugenn14	286	7	fetal	fetal	JJ
cord-337365-hugenn14	286	8	cerebellar	cerebellar	JJ
cord-337365-hugenn14	286	9	malformation	malformation	NN
cord-337365-hugenn14	286	10	and	and	CC
cord-337365-hugenn14	286	11	activation	activation	NN
cord-337365-hugenn14	286	12	of	of	IN
cord-337365-hugenn14	286	13	microglia	microglia	NN
cord-337365-hugenn14	286	14	in	in	IN
cord-337365-hugenn14	286	15	ZIKV	ZIKV	NNP
cord-337365-hugenn14	286	16	infection	infection	NN
cord-337365-hugenn14	286	17	,	,	,
cord-337365-hugenn14	286	18	and	and	CC
cord-337365-hugenn14	286	19	it	-PRON-	PRP
cord-337365-hugenn14	286	20	is	be	VBZ
cord-337365-hugenn14	286	21	necessary	necessary	JJ
cord-337365-hugenn14	286	22	to	to	TO
cord-337365-hugenn14	286	23	develop	develop	VB
cord-337365-hugenn14	286	24	microglia	microglia	JJ
cord-337365-hugenn14	286	25	inhibitors	inhibitor	NNS
cord-337365-hugenn14	286	26	that	that	WDT
cord-337365-hugenn14	286	27	are	be	VBP
cord-337365-hugenn14	286	28	safe	safe	JJ
cord-337365-hugenn14	286	29	for	for	IN
cord-337365-hugenn14	286	30	pregnant	pregnant	JJ
cord-337365-hugenn14	286	31	women	woman	NNS
cord-337365-hugenn14	286	32	and	and	CC
cord-337365-hugenn14	286	33	fetuses	fetus	NNS
cord-337365-hugenn14	286	34	.	.	.
cord-337365-hugenn14	287	1	Pelia	Pelia	NNP
cord-337365-hugenn14	287	2	of	of	IN
cord-337365-hugenn14	287	3	microglia	microglia	NNP
cord-337365-hugenn14	287	4	promotes	promote	VBZ
cord-337365-hugenn14	287	5	viral	viral	JJ
cord-337365-hugenn14	287	6	replication	replication	NN
cord-337365-hugenn14	287	7	in	in	IN
cord-337365-hugenn14	287	8	neurons	neuron	NNS
cord-337365-hugenn14	287	9	,	,	,
cord-337365-hugenn14	287	10	and	and	CC
cord-337365-hugenn14	287	11	moderate	moderate	JJ
cord-337365-hugenn14	287	12	blockade	blockade	NN
cord-337365-hugenn14	287	13	of	of	IN
cord-337365-hugenn14	287	14	pelia	pelia	NNP
cord-337365-hugenn14	287	15	may	may	MD
cord-337365-hugenn14	287	16	become	become	VB
cord-337365-hugenn14	287	17	a	a	DT
cord-337365-hugenn14	287	18	target	target	NN
cord-337365-hugenn14	287	19	for	for	IN
cord-337365-hugenn14	287	20	future	future	JJ
cord-337365-hugenn14	287	21	treatment	treatment	NN
cord-337365-hugenn14	287	22	.	.	.
cord-337365-hugenn14	288	1	In	in	IN
cord-337365-hugenn14	288	2	viral	viral	JJ
cord-337365-hugenn14	288	3	encephalitis	encephalitis	NN
cord-337365-hugenn14	288	4	,	,	,
cord-337365-hugenn14	288	5	Aβ	Aβ	NNP
cord-337365-hugenn14	288	6	produced	produce	VBN
cord-337365-hugenn14	288	7	by	by	IN
cord-337365-hugenn14	288	8	neurons	neuron	NNS
cord-337365-hugenn14	288	9	increases	increase	VBZ
cord-337365-hugenn14	288	10	the	the	DT
cord-337365-hugenn14	288	11	risk	risk	NN
cord-337365-hugenn14	288	12	of	of	IN
cord-337365-hugenn14	288	13	dementia	dementia	NN
cord-337365-hugenn14	288	14	in	in	IN
cord-337365-hugenn14	288	15	patients	patient	NNS
cord-337365-hugenn14	288	16	.	.	.
cord-337365-hugenn14	289	1	Studies	study	NNS
cord-337365-hugenn14	289	2	show	show	VBP
cord-337365-hugenn14	289	3	that	that	IN
cord-337365-hugenn14	289	4	prolonging	prolong	VBG
cord-337365-hugenn14	289	5	antiviral	antiviral	JJ
cord-337365-hugenn14	289	6	time	time	NN
cord-337365-hugenn14	289	7	will	will	MD
cord-337365-hugenn14	289	8	reduce	reduce	VB
cord-337365-hugenn14	289	9	the	the	DT
cord-337365-hugenn14	289	10	risk	risk	NN
cord-337365-hugenn14	289	11	of	of	IN
cord-337365-hugenn14	289	12	dementia	dementia	NN
cord-337365-hugenn14	289	13	.	.	.
cord-337365-hugenn14	290	1	The	the	DT
cord-337365-hugenn14	290	2	interaction	interaction	NN
cord-337365-hugenn14	290	3	between	between	IN
cord-337365-hugenn14	290	4	Aβ	Aβ	NNP
cord-337365-hugenn14	290	5	and	and	CC
cord-337365-hugenn14	290	6	activated	activate	VBD
cord-337365-hugenn14	290	7	microglia	microglia	NNS
cord-337365-hugenn14	290	8	in	in	IN
cord-337365-hugenn14	290	9	patients	patient	NNS
cord-337365-hugenn14	290	10	with	with	IN
cord-337365-hugenn14	290	11	viral	viral	JJ
cord-337365-hugenn14	290	12	encephalitis	encephalitis	NN
cord-337365-hugenn14	290	13	is	be	VBZ
cord-337365-hugenn14	290	14	unknown	unknown	JJ
cord-337365-hugenn14	290	15	.	.	.
cord-337365-hugenn14	291	1	It	-PRON-	PRP
cord-337365-hugenn14	291	2	is	be	VBZ
cord-337365-hugenn14	291	3	unknown	unknown	JJ
cord-337365-hugenn14	291	4	whether	whether	IN
cord-337365-hugenn14	291	5	moderately	moderately	RB
cord-337365-hugenn14	291	6	enhancing	enhance	VBG
cord-337365-hugenn14	291	7	the	the	DT
cord-337365-hugenn14	291	8	phagocytosis	phagocytosis	NN
cord-337365-hugenn14	291	9	of	of	IN
cord-337365-hugenn14	291	10	microglia	microglia	NNS
cord-337365-hugenn14	291	11	can	can	MD
cord-337365-hugenn14	291	12	reduce	reduce	VB
cord-337365-hugenn14	291	13	the	the	DT
cord-337365-hugenn14	291	14	risk	risk	NN
cord-337365-hugenn14	291	15	of	of	IN
cord-337365-hugenn14	291	16	dementia	dementia	NN
cord-337365-hugenn14	291	17	.	.	.
cord-337365-hugenn14	292	1	It	-PRON-	PRP
cord-337365-hugenn14	292	2	needs	need	VBZ
cord-337365-hugenn14	292	3	further	further	JJ
cord-337365-hugenn14	292	4	research	research	NN
cord-337365-hugenn14	292	5	.	.	.
cord-337365-hugenn14	293	1	Traditionally	traditionally	RB
cord-337365-hugenn14	293	2	,	,	,
cord-337365-hugenn14	293	3	activation	activation	NN
cord-337365-hugenn14	293	4	of	of	IN
cord-337365-hugenn14	293	5	RIPK3	ripk3	NN
cord-337365-hugenn14	293	6	will	will	MD
cord-337365-hugenn14	293	7	result	result	VB
cord-337365-hugenn14	293	8	in	in	IN
cord-337365-hugenn14	293	9	the	the	DT
cord-337365-hugenn14	293	10	formation	formation	NN
cord-337365-hugenn14	293	11	of	of	IN
cord-337365-hugenn14	293	12	an	an	DT
cord-337365-hugenn14	293	13	apoptotic	apoptotic	JJ
cord-337365-hugenn14	293	14	complex	complex	NN
cord-337365-hugenn14	293	15	that	that	WDT
cord-337365-hugenn14	293	16	mediates	mediate	VBZ
cord-337365-hugenn14	293	17	cell	cell	NN
cord-337365-hugenn14	293	18	death	death	NN
cord-337365-hugenn14	293	19	.	.	.
cord-337365-hugenn14	294	1	Recent	recent	JJ
cord-337365-hugenn14	294	2	studies	study	NNS
cord-337365-hugenn14	294	3	have	have	VBP
cord-337365-hugenn14	294	4	shown	show	VBN
cord-337365-hugenn14	294	5	that	that	IN
cord-337365-hugenn14	294	6	in	in	IN
cord-337365-hugenn14	294	7	viral	viral	JJ
cord-337365-hugenn14	294	8	encephalitis	encephalitis	NN
cord-337365-hugenn14	294	9	,	,	,
cord-337365-hugenn14	294	10	activation	activation	NN
cord-337365-hugenn14	294	11	of	of	IN
cord-337365-hugenn14	294	12	neuronal	neuronal	JJ
cord-337365-hugenn14	294	13	RIPK3	ripk3	NN
cord-337365-hugenn14	294	14	exerts	exert	VBZ
cord-337365-hugenn14	294	15	an	an	DT
cord-337365-hugenn14	294	16	antiviral	antiviral	JJ
cord-337365-hugenn14	294	17	effect	effect	NN
cord-337365-hugenn14	294	18	in	in	IN
cord-337365-hugenn14	294	19	a	a	DT
cord-337365-hugenn14	294	20	death	death	NN
cord-337365-hugenn14	294	21	-	-	HYPH
cord-337365-hugenn14	294	22	independent	independent	JJ
cord-337365-hugenn14	294	23	pathway	pathway	NN
cord-337365-hugenn14	294	24	,	,	,
cord-337365-hugenn14	294	25	and	and	CC
cord-337365-hugenn14	294	26	the	the	DT
cord-337365-hugenn14	294	27	RIPK3	ripk3	NN
cord-337365-hugenn14	294	28	pathway	pathway	NN
cord-337365-hugenn14	294	29	of	of	IN
cord-337365-hugenn14	294	30	microglia	microglia	NNP
cord-337365-hugenn14	294	31	requires	require	VBZ
cord-337365-hugenn14	294	32	further	further	JJ
cord-337365-hugenn14	294	33	investigation	investigation	NN
cord-337365-hugenn14	294	34	.	.	.
cord-337365-hugenn14	295	1	Microglia	Microglia	NNP
cord-337365-hugenn14	295	2	account	account	VBP
cord-337365-hugenn14	295	3	for	for	IN
cord-337365-hugenn14	295	4	10	10	CD
cord-337365-hugenn14	295	5	%	%	NN
cord-337365-hugenn14	295	6	of	of	IN
cord-337365-hugenn14	295	7	the	the	DT
cord-337365-hugenn14	295	8	total	total	JJ
cord-337365-hugenn14	295	9	number	number	NN
cord-337365-hugenn14	295	10	of	of	IN
cord-337365-hugenn14	295	11	cells	cell	NNS
cord-337365-hugenn14	295	12	in	in	IN
cord-337365-hugenn14	295	13	the	the	DT
cord-337365-hugenn14	295	14	adult	adult	NN
cord-337365-hugenn14	295	15	central	central	JJ
cord-337365-hugenn14	295	16	nervous	nervous	JJ
cord-337365-hugenn14	295	17	system	system	NN
cord-337365-hugenn14	295	18	[	[	-LRB-
cord-337365-hugenn14	295	19	91	91	CD
cord-337365-hugenn14	295	20	]	]	-RRB-
cord-337365-hugenn14	295	21	.	.	.
cord-337365-hugenn14	296	1	In	in	IN
cord-337365-hugenn14	296	2	a	a	DT
cord-337365-hugenn14	296	3	healthy	healthy	JJ
cord-337365-hugenn14	296	4	CNS	CNS	NNP
cord-337365-hugenn14	296	5	,	,	,
cord-337365-hugenn14	296	6	microglia	microglia	NNS
cord-337365-hugenn14	296	7	are	be	VBP
cord-337365-hugenn14	296	8	not	not	RB
cord-337365-hugenn14	296	9	"	"	``
cord-337365-hugenn14	296	10	resting	rest	VBG
cord-337365-hugenn14	296	11	"	"	''
cord-337365-hugenn14	296	12	but	but	CC
cord-337365-hugenn14	296	13	in	in	IN
cord-337365-hugenn14	296	14	a	a	DT
cord-337365-hugenn14	296	15	highly	highly	RB
cord-337365-hugenn14	296	16	active	active	JJ
cord-337365-hugenn14	296	17	"	"	''
cord-337365-hugenn14	296	18	surveillance	surveillance	NN
cord-337365-hugenn14	296	19	and	and	CC
cord-337365-hugenn14	296	20	rapid	rapid	JJ
cord-337365-hugenn14	296	21	response	response	NN
cord-337365-hugenn14	296	22	"	"	''
cord-337365-hugenn14	296	23	state	state	NN
cord-337365-hugenn14	296	24	[	[	-LRB-
cord-337365-hugenn14	296	25	92	92	CD
cord-337365-hugenn14	296	26	]	]	-RRB-
cord-337365-hugenn14	296	27	.	.	.
cord-337365-hugenn14	297	1	Microglia	Microglia	NNP
cord-337365-hugenn14	297	2	processes	process	NNS
cord-337365-hugenn14	297	3	are	be	VBP
cord-337365-hugenn14	297	4	dynamic	dynamic	JJ
cord-337365-hugenn14	297	5	,	,	,
cord-337365-hugenn14	297	6	continuously	continuously	RB
cord-337365-hugenn14	297	7	scanning	scan	VBG
cord-337365-hugenn14	297	8	the	the	DT
cord-337365-hugenn14	297	9	environment	environment	NN
cord-337365-hugenn14	297	10	and	and	CC
cord-337365-hugenn14	297	11	sampling	sample	VBG
cord-337365-hugenn14	297	12	it	-PRON-	PRP
cord-337365-hugenn14	297	13	[	[	-LRB-
cord-337365-hugenn14	297	14	93	93	CD
cord-337365-hugenn14	297	15	]	]	-RRB-
cord-337365-hugenn14	297	16	.	.	.
cord-337365-hugenn14	298	1	They	-PRON-	PRP
cord-337365-hugenn14	298	2	are	be	VBP
cord-337365-hugenn14	298	3	able	able	JJ
cord-337365-hugenn14	298	4	to	to	TO
cord-337365-hugenn14	298	5	detect	detect	VB
cord-337365-hugenn14	298	6	changes	change	NNS
cord-337365-hugenn14	298	7	in	in	IN
cord-337365-hugenn14	298	8	pH	pH	NNP
cord-337365-hugenn14	298	9	,	,	,
cord-337365-hugenn14	298	10	purines	purine	NNS
cord-337365-hugenn14	298	11	,	,	,
cord-337365-hugenn14	298	12	cytokines	cytokine	NNS
cord-337365-hugenn14	298	13	,	,	,
cord-337365-hugenn14	298	14	chemokines	chemokine	NNS
cord-337365-hugenn14	298	15	,	,	,
cord-337365-hugenn14	298	16	amino	amino	JJ
cord-337365-hugenn14	298	17	acids	acid	NNS
cord-337365-hugenn14	298	18	,	,	,
cord-337365-hugenn14	298	19	and	and	CC
cord-337365-hugenn14	298	20	inorganic	inorganic	JJ
cord-337365-hugenn14	298	21	compounds	compound	NNS
cord-337365-hugenn14	298	22	[	[	-LRB-
cord-337365-hugenn14	298	23	94	94	CD
cord-337365-hugenn14	298	24	]	]	-RRB-
cord-337365-hugenn14	298	25	.	.	.
cord-337365-hugenn14	299	1	Microglia	Microglia	NNP
cord-337365-hugenn14	299	2	are	be	VBP
cord-337365-hugenn14	299	3	derived	derive	VBN
cord-337365-hugenn14	299	4	from	from	IN
cord-337365-hugenn14	299	5	the	the	DT
cord-337365-hugenn14	299	6	primitive	primitive	JJ
cord-337365-hugenn14	299	7	macrophages	macrophage	NNS
cord-337365-hugenn14	299	8	of	of	IN
cord-337365-hugenn14	299	9	the	the	DT
cord-337365-hugenn14	299	10	yolk	yolk	NN
cord-337365-hugenn14	299	11	sac	sac	NN
cord-337365-hugenn14	299	12	,	,	,
cord-337365-hugenn14	299	13	which	which	WDT
cord-337365-hugenn14	299	14	migrate	migrate	VBP
cord-337365-hugenn14	299	15	to	to	IN
cord-337365-hugenn14	299	16	the	the	DT
cord-337365-hugenn14	299	17	developing	develop	VBG
cord-337365-hugenn14	299	18	central	central	JJ
cord-337365-hugenn14	299	19	nervous	nervous	JJ
cord-337365-hugenn14	299	20	system	system	NN
cord-337365-hugenn14	299	21	.	.	.
cord-337365-hugenn14	300	1	They	-PRON-	PRP
cord-337365-hugenn14	300	2	have	have	VBP
cord-337365-hugenn14	300	3	the	the	DT
cord-337365-hugenn14	300	4	ability	ability	NN
cord-337365-hugenn14	300	5	to	to	TO
cord-337365-hugenn14	300	6	self	self	NN
cord-337365-hugenn14	300	7	-	-	HYPH
cord-337365-hugenn14	300	8	renew	renew	VB
cord-337365-hugenn14	300	9	,	,	,
cord-337365-hugenn14	300	10	thus	thus	RB
cord-337365-hugenn14	300	11	maintaining	maintain	VBG
cord-337365-hugenn14	300	12	their	-PRON-	PRP$
cord-337365-hugenn14	300	13	number	number	NN
cord-337365-hugenn14	300	14	throughout	throughout	IN
cord-337365-hugenn14	300	15	life	life	NN
cord-337365-hugenn14	300	16	without	without	IN
cord-337365-hugenn14	300	17	any	any	DT
cord-337365-hugenn14	300	18	input	input	NN
cord-337365-hugenn14	300	19	from	from	IN
cord-337365-hugenn14	300	20	the	the	DT
cord-337365-hugenn14	300	21	bone	bone	NN
cord-337365-hugenn14	300	22	marrow	marrow	NN
cord-337365-hugenn14	300	23	-	-	HYPH
cord-337365-hugenn14	300	24	derived	derive	VBN
cord-337365-hugenn14	300	25	precursor	precursor	NN
cord-337365-hugenn14	300	26	cells	cell	NNS
cord-337365-hugenn14	300	27	[	[	-LRB-
cord-337365-hugenn14	300	28	95	95	CD
cord-337365-hugenn14	300	29	,	,	,
cord-337365-hugenn14	300	30	96	96	CD
cord-337365-hugenn14	300	31	]	]	-RRB-
cord-337365-hugenn14	300	32	.	.	.
cord-337365-hugenn14	301	1	Microglia	Microglia	NNP
cord-337365-hugenn14	301	2	can	can	MD
cord-337365-hugenn14	301	3	respond	respond	VB
cord-337365-hugenn14	301	4	to	to	IN
cord-337365-hugenn14	301	5	neurons	neuron	NNS
cord-337365-hugenn14	301	6	,	,	,
cord-337365-hugenn14	301	7	which	which	WDT
cord-337365-hugenn14	301	8	in	in	IN
cord-337365-hugenn14	301	9	turn	turn	NN
cord-337365-hugenn14	301	10	affects	affect	VBZ
cord-337365-hugenn14	301	11	neuronal	neuronal	JJ
cord-337365-hugenn14	301	12	activity	activity	NN
cord-337365-hugenn14	301	13	.	.	.
cord-337365-hugenn14	302	1	Microglia	Microglia	NNP
cord-337365-hugenn14	302	2	are	be	VBP
cord-337365-hugenn14	302	3	involved	involve	VBN
cord-337365-hugenn14	302	4	in	in	IN
cord-337365-hugenn14	302	5	the	the	DT
cord-337365-hugenn14	302	6	programmed	program	VBN
cord-337365-hugenn14	302	7	death	death	NN
cord-337365-hugenn14	302	8	of	of	IN
cord-337365-hugenn14	302	9	neurons	neuron	NNS
cord-337365-hugenn14	302	10	and	and	CC
cord-337365-hugenn14	302	11	the	the	DT
cord-337365-hugenn14	302	12	apoptosis	apoptosis	NN
cord-337365-hugenn14	302	13	and	and	CC
cord-337365-hugenn14	302	14	clearance	clearance	NN
cord-337365-hugenn14	302	15	of	of	IN
cord-337365-hugenn14	302	16	new	new	JJ
cord-337365-hugenn14	302	17	neurons	neuron	NNS
cord-337365-hugenn14	302	18	during	during	IN
cord-337365-hugenn14	302	19	development	development	NN
cord-337365-hugenn14	302	20	.	.	.
cord-337365-hugenn14	303	1	The	the	DT
cord-337365-hugenn14	303	2	activity	activity	NN
cord-337365-hugenn14	303	3	of	of	IN
cord-337365-hugenn14	303	4	microglia	microglia	NN
cord-337365-hugenn14	303	5	promotes	promote	VBZ
cord-337365-hugenn14	303	6	the	the	DT
cord-337365-hugenn14	303	7	pruning	pruning	NN
cord-337365-hugenn14	303	8	,	,	,
cord-337365-hugenn14	303	9	elimination	elimination	NN
cord-337365-hugenn14	303	10	,	,	,
cord-337365-hugenn14	303	11	and	and	CC
cord-337365-hugenn14	303	12	maturation	maturation	NN
cord-337365-hugenn14	303	13	of	of	IN
cord-337365-hugenn14	303	14	synapses	synapsis	NNS
cord-337365-hugenn14	303	15	[	[	-LRB-
cord-337365-hugenn14	303	16	92	92	CD
cord-337365-hugenn14	303	17	]	]	-RRB-
cord-337365-hugenn14	303	18	.	.	.
cord-337365-hugenn14	304	1	Microglia	Microglia	NNP
cord-337365-hugenn14	304	2	serve	serve	VBP
cord-337365-hugenn14	304	3	important	important	JJ
cord-337365-hugenn14	304	4	physiological	physiological	JJ
cord-337365-hugenn14	304	5	functions	function	NNS
cord-337365-hugenn14	304	6	in	in	IN
cord-337365-hugenn14	304	7	learning	learning	NN
cord-337365-hugenn14	304	8	and	and	CC
cord-337365-hugenn14	304	9	memory	memory	NN
cord-337365-hugenn14	304	10	by	by	IN
cord-337365-hugenn14	304	11	promoting	promote	VBG
cord-337365-hugenn14	304	12	learning	learning	NN
cord-337365-hugenn14	304	13	-	-	HYPH
cord-337365-hugenn14	304	14	related	relate	VBN
cord-337365-hugenn14	304	15	synapse	synapse	NN
cord-337365-hugenn14	304	16	formation	formation	NN
cord-337365-hugenn14	304	17	through	through	IN
cord-337365-hugenn14	304	18	BDNF	BDNF	NNP
cord-337365-hugenn14	304	19	signaling	signal	VBG
cord-337365-hugenn14	304	20	[	[	-LRB-
cord-337365-hugenn14	304	21	80	80	CD
cord-337365-hugenn14	304	22	]	]	-RRB-
cord-337365-hugenn14	304	23	.	.	.
cord-337365-hugenn14	305	1	The	the	DT
cord-337365-hugenn14	305	2	phagocytic	phagocytic	JJ
cord-337365-hugenn14	305	3	activity	activity	NN
cord-337365-hugenn14	305	4	of	of	IN
cord-337365-hugenn14	305	5	microglia	microglia	NN
cord-337365-hugenn14	305	6	is	be	VBZ
cord-337365-hugenn14	305	7	essential	essential	JJ
cord-337365-hugenn14	305	8	for	for	IN
cord-337365-hugenn14	305	9	the	the	DT
cord-337365-hugenn14	305	10	clearance	clearance	NN
cord-337365-hugenn14	305	11	of	of	IN
cord-337365-hugenn14	305	12	senescent	senescent	JJ
cord-337365-hugenn14	305	13	cells	cell	NNS
cord-337365-hugenn14	305	14	and	and	CC
cord-337365-hugenn14	305	15	debris	debris	NN
cord-337365-hugenn14	305	16	[	[	-LRB-
cord-337365-hugenn14	305	17	97	97	CD
cord-337365-hugenn14	305	18	]	]	-RRB-
cord-337365-hugenn14	305	19	,	,	,
cord-337365-hugenn14	305	20	slowing	slow	VBG
cord-337365-hugenn14	305	21	the	the	DT
cord-337365-hugenn14	305	22	toxic	toxic	JJ
cord-337365-hugenn14	305	23	effects	effect	NNS
cord-337365-hugenn14	305	24	of	of	IN
cord-337365-hugenn14	305	25	amyloid	amyloid	NN
cord-337365-hugenn14	305	26	-	-	HYPH
cord-337365-hugenn14	305	27	β	β	NN
cord-337365-hugenn14	305	28	[	[	-LRB-
cord-337365-hugenn14	305	29	98	98	CD
cord-337365-hugenn14	305	30	]	]	-RRB-
cord-337365-hugenn14	305	31	.	.	.
cord-337365-hugenn14	306	1	Microglia	Microglia	NNP
cord-337365-hugenn14	306	2	are	be	VBP
cord-337365-hugenn14	306	3	not	not	RB
cord-337365-hugenn14	306	4	only	only	RB
cord-337365-hugenn14	306	5	important	important	JJ
cord-337365-hugenn14	306	6	cells	cell	NNS
cord-337365-hugenn14	306	7	that	that	WDT
cord-337365-hugenn14	306	8	maintain	maintain	VBP
cord-337365-hugenn14	306	9	the	the	DT
cord-337365-hugenn14	306	10	homeostasis	homeostasis	NN
cord-337365-hugenn14	306	11	of	of	IN
cord-337365-hugenn14	306	12	CNS	CNS	NNP
cord-337365-hugenn14	306	13	,	,	,
cord-337365-hugenn14	306	14	but	but	CC
cord-337365-hugenn14	306	15	also	also	RB
cord-337365-hugenn14	306	16	respond	respond	VB
cord-337365-hugenn14	306	17	to	to	IN
cord-337365-hugenn14	306	18	injury	injury	NN
cord-337365-hugenn14	306	19	,	,	,
cord-337365-hugenn14	306	20	infection	infection	NN
cord-337365-hugenn14	306	21	,	,	,
cord-337365-hugenn14	306	22	and	and	CC
cord-337365-hugenn14	306	23	neurodegeneration	neurodegeneration	NN
cord-337365-hugenn14	306	24	through	through	IN
cord-337365-hugenn14	306	25	proliferation	proliferation	NN
cord-337365-hugenn14	306	26	and	and	CC
cord-337365-hugenn14	306	27	altered	alter	VBN
cord-337365-hugenn14	306	28	transcription	transcription	NN
cord-337365-hugenn14	306	29	and	and	CC
cord-337365-hugenn14	306	30	morphology	morphology	NN
cord-337365-hugenn14	306	31	[	[	-LRB-
cord-337365-hugenn14	306	32	99	99	CD
cord-337365-hugenn14	306	33	,	,	,
cord-337365-hugenn14	306	34	92	92	CD
cord-337365-hugenn14	306	35	]	]	-RRB-
cord-337365-hugenn14	306	36	.	.	.
cord-337365-hugenn14	307	1	Microglia	Microglia	NNP
cord-337365-hugenn14	307	2	are	be	VBP
cord-337365-hugenn14	307	3	often	often	RB
cord-337365-hugenn14	307	4	touted	tout	VBN
cord-337365-hugenn14	307	5	as	as	IN
cord-337365-hugenn14	307	6	the	the	DT
cord-337365-hugenn14	307	7	first	first	JJ
cord-337365-hugenn14	307	8	responder	responder	NN
cord-337365-hugenn14	307	9	to	to	IN
cord-337365-hugenn14	307	10	CNS	CNS	NNP
cord-337365-hugenn14	307	11	infection	infection	NN
cord-337365-hugenn14	307	12	and	and	CC
cord-337365-hugenn14	307	13	respond	respond	VB
cord-337365-hugenn14	307	14	quickly	quickly	RB
cord-337365-hugenn14	307	15	to	to	TO
cord-337365-hugenn14	307	16	injury	injury	VB
cord-337365-hugenn14	307	17	[	[	-LRB-
cord-337365-hugenn14	307	18	93	93	CD
cord-337365-hugenn14	307	19	]	]	-RRB-
cord-337365-hugenn14	307	20	.	.	.
cord-337365-hugenn14	308	1	However	however	RB
cord-337365-hugenn14	308	2	,	,	,
cord-337365-hugenn14	308	3	depending	depend	VBG
cord-337365-hugenn14	308	4	on	on	IN
cord-337365-hugenn14	308	5	the	the	DT
cord-337365-hugenn14	308	6	stimulus	stimulus	NN
cord-337365-hugenn14	308	7	received	receive	VBN
cord-337365-hugenn14	308	8	,	,	,
cord-337365-hugenn14	308	9	this	this	DT
cord-337365-hugenn14	308	10	activation	activation	NN
cord-337365-hugenn14	308	11	profile	profile	NN
cord-337365-hugenn14	308	12	is	be	VBZ
cord-337365-hugenn14	308	13	also	also	RB
cord-337365-hugenn14	308	14	different	different	JJ
cord-337365-hugenn14	308	15	and	and	CC
cord-337365-hugenn14	308	16	may	may	MD
cord-337365-hugenn14	308	17	result	result	VB
cord-337365-hugenn14	308	18	in	in	IN
cord-337365-hugenn14	308	19	harmful	harmful	JJ
cord-337365-hugenn14	308	20	or	or	CC
cord-337365-hugenn14	308	21	beneficial	beneficial	JJ
cord-337365-hugenn14	308	22	effects	effect	NNS
cord-337365-hugenn14	308	23	[	[	-LRB-
cord-337365-hugenn14	308	24	100	100	CD
cord-337365-hugenn14	308	25	,	,	,
cord-337365-hugenn14	308	26	6	6	CD
cord-337365-hugenn14	308	27	]	]	-RRB-
cord-337365-hugenn14	308	28	.	.	.
cord-337365-hugenn14	309	1	HSV-1	HSV-1	NNS
cord-337365-hugenn14	309	2	can	can	MD
cord-337365-hugenn14	309	3	be	be	VB
cord-337365-hugenn14	309	4	treated	treat	VBN
cord-337365-hugenn14	309	5	,	,	,
cord-337365-hugenn14	309	6	but	but	CC
cord-337365-hugenn14	309	7	can	can	MD
cord-337365-hugenn14	309	8	WNV	WNV	NNP
cord-337365-hugenn14	309	9	or	or	CC
cord-337365-hugenn14	309	10	enteroviruses	enterovirus	NNS
cord-337365-hugenn14	309	11	?	?	.
cord-337365-hugenn14	310	1	The	the	DT
cord-337365-hugenn14	310	2	high	high	JJ
cord-337365-hugenn14	310	3	morbidity	morbidity	NN
cord-337365-hugenn14	310	4	and	and	CC
cord-337365-hugenn14	310	5	high	high	JJ
cord-337365-hugenn14	310	6	morbidity	morbidity	NN
cord-337365-hugenn14	310	7	rate	rate	NN
cord-337365-hugenn14	310	8	of	of	IN
cord-337365-hugenn14	310	9	viral	viral	JJ
cord-337365-hugenn14	310	10	encephalitis	encephaliti	NNS
cord-337365-hugenn14	310	11	have	have	VBP
cord-337365-hugenn14	310	12	caused	cause	VBN
cord-337365-hugenn14	310	13	widespread	widespread	JJ
cord-337365-hugenn14	310	14	concern	concern	NN
cord-337365-hugenn14	310	15	.	.	.
cord-337365-hugenn14	311	1	Although	although	IN
cord-337365-hugenn14	311	2	traditional	traditional	JJ
cord-337365-hugenn14	311	3	antiviral	antiviral	JJ
cord-337365-hugenn14	311	4	therapy	therapy	NN
cord-337365-hugenn14	311	5	is	be	VBZ
cord-337365-hugenn14	311	6	effective	effective	JJ
cord-337365-hugenn14	311	7	,	,	,
cord-337365-hugenn14	311	8	there	there	EX
cord-337365-hugenn14	311	9	are	be	VBP
cord-337365-hugenn14	311	10	still	still	RB
cord-337365-hugenn14	311	11	many	many	JJ
cord-337365-hugenn14	311	12	shortcomings	shortcoming	NNS
cord-337365-hugenn14	311	13	.	.	.
cord-337365-hugenn14	312	1	Research	research	NN
cord-337365-hugenn14	312	2	on	on	IN
cord-337365-hugenn14	312	3	microglia	microglia	JJ
cord-337365-hugenn14	312	4	and	and	CC
cord-337365-hugenn14	312	5	viral	viral	JJ
cord-337365-hugenn14	312	6	encephalitis	encephalitis	RB
cord-337365-hugenn14	312	7	provides	provide	VBZ
cord-337365-hugenn14	312	8	new	new	JJ
cord-337365-hugenn14	312	9	targets	target	NNS
cord-337365-hugenn14	312	10	for	for	IN
cord-337365-hugenn14	312	11	treatment	treatment	NN
cord-337365-hugenn14	312	12	.	.	.
cord-337365-hugenn14	313	1	Microglia	Microglia	NNP
cord-337365-hugenn14	313	2	play	play	VBP
cord-337365-hugenn14	313	3	a	a	DT
cord-337365-hugenn14	313	4	unique	unique	JJ
cord-337365-hugenn14	313	5	role	role	NN
cord-337365-hugenn14	313	6	in	in	IN
cord-337365-hugenn14	313	7	different	different	JJ
cord-337365-hugenn14	313	8	encephalitis	encephalitis	NN
cord-337365-hugenn14	313	9	.	.	.
cord-337365-hugenn14	314	1	The	the	DT
cord-337365-hugenn14	314	2	current	current	JJ
cord-337365-hugenn14	314	3	research	research	NN
cord-337365-hugenn14	314	4	on	on	IN
cord-337365-hugenn14	314	5	microglia	microglia	NN
cord-337365-hugenn14	314	6	and	and	CC
cord-337365-hugenn14	314	7	viral	viral	JJ
cord-337365-hugenn14	314	8	encephalitis	encephalitis	NN
cord-337365-hugenn14	314	9	remains	remain	VBZ
cord-337365-hugenn14	314	10	at	at	IN
cord-337365-hugenn14	314	11	the	the	DT
cord-337365-hugenn14	314	12	experimental	experimental	JJ
cord-337365-hugenn14	314	13	stage	stage	NN
cord-337365-hugenn14	314	14	.	.	.
cord-337365-hugenn14	315	1	In	in	IN
cord-337365-hugenn14	315	2	the	the	DT
cord-337365-hugenn14	315	3	future	future	NN
cord-337365-hugenn14	315	4	,	,	,
cord-337365-hugenn14	315	5	depending	depend	VBG
cord-337365-hugenn14	315	6	on	on	IN
cord-337365-hugenn14	315	7	the	the	DT
cord-337365-hugenn14	315	8	type	type	NN
cord-337365-hugenn14	315	9	of	of	IN
cord-337365-hugenn14	315	10	encephalitis	encephalitis	NN
cord-337365-hugenn14	315	11	,	,	,
cord-337365-hugenn14	315	12	rationally	rationally	RB
cord-337365-hugenn14	315	13	enhancing	enhance	VBG
cord-337365-hugenn14	315	14	or	or	CC
cord-337365-hugenn14	315	15	inhibiting	inhibit	VBG
cord-337365-hugenn14	315	16	the	the	DT
cord-337365-hugenn14	315	17	activation	activation	NN
cord-337365-hugenn14	315	18	of	of	IN
cord-337365-hugenn14	315	19	microglia	microglia	NNP
cord-337365-hugenn14	315	20	will	will	MD
cord-337365-hugenn14	315	21	greatly	greatly	RB
cord-337365-hugenn14	315	22	improve	improve	VB
cord-337365-hugenn14	315	23	the	the	DT
cord-337365-hugenn14	315	24	therapeutic	therapeutic	JJ
cord-337365-hugenn14	315	25	effect	effect	NN
cord-337365-hugenn14	315	26	of	of	IN
cord-337365-hugenn14	315	27	encephalitis	encephalitis	NN
cord-337365-hugenn14	315	28	,	,	,
cord-337365-hugenn14	315	29	improve	improve	VB
cord-337365-hugenn14	315	30	the	the	DT
cord-337365-hugenn14	315	31	prognosis	prognosis	NN
cord-337365-hugenn14	315	32	of	of	IN
cord-337365-hugenn14	315	33	traditional	traditional	JJ
cord-337365-hugenn14	315	34	antiviral	antiviral	JJ
cord-337365-hugenn14	315	35	therapy	therapy	NN
cord-337365-hugenn14	315	36	,	,	,
cord-337365-hugenn14	315	37	and	and	CC
cord-337365-hugenn14	315	38	reduce	reduce	VB
cord-337365-hugenn14	315	39	the	the	DT
cord-337365-hugenn14	315	40	sequelae	sequela	NNS
cord-337365-hugenn14	315	41	of	of	IN
cord-337365-hugenn14	315	42	encephalitis	encephalitis	NN
cord-337365-hugenn14	315	43	.	.	.
cord-337365-hugenn14	315	44	 	 	_SP
cord-337365-hugenn14	316	1	Acute	acute	JJ
cord-337365-hugenn14	316	2	Viral	Viral	NNP
cord-337365-hugenn14	316	3	Encephalitis	Encephalitis	NNP
cord-337365-hugenn14	316	4	Kenneth	Kenneth	NNP
cord-337365-hugenn14	316	5	L	L	NNP
cord-337365-hugenn14	316	6	Encephalitis	Encephalitis	NNP
cord-337365-hugenn14	316	7	hospitalization	hospitalization	NN
cord-337365-hugenn14	316	8	rates	rate	NNS
cord-337365-hugenn14	316	9	and	and	CC
cord-337365-hugenn14	316	10	inpatient	inpatient	JJ
cord-337365-hugenn14	316	11	mortality	mortality	NN
cord-337365-hugenn14	316	12	in	in	IN
cord-337365-hugenn14	316	13	the	the	DT
cord-337365-hugenn14	316	14	United	United	NNP
cord-337365-hugenn14	316	15	States	States	NNP
cord-337365-hugenn14	316	16	Burden	Burden	NNP
cord-337365-hugenn14	316	17	of	of	IN
cord-337365-hugenn14	316	18	encephalitis	encephalitis	RB
cord-337365-hugenn14	316	19	-	-	HYPH
cord-337365-hugenn14	316	20	associated	associate	VBN
cord-337365-hugenn14	316	21	hospitalizations	hospitalization	NNS
cord-337365-hugenn14	316	22	in	in	IN
cord-337365-hugenn14	316	23	the	the	DT
cord-337365-hugenn14	316	24	United	United	NNP
cord-337365-hugenn14	316	25	States	States	NNP
cord-337365-hugenn14	317	1	The	the	DT
cord-337365-hugenn14	317	2	microglial	microglial	JJ
cord-337365-hugenn14	317	3	sensome	sensome	NNP
cord-337365-hugenn14	317	4	revealed	reveal	VBN
cord-337365-hugenn14	317	5	by	by	IN
cord-337365-hugenn14	317	6	direct	direct	JJ
cord-337365-hugenn14	317	7	RNA	RNA	NNP
cord-337365-hugenn14	317	8	sequencing	sequencing	NN
cord-337365-hugenn14	317	9	Tissue	tissue	NN
cord-337365-hugenn14	317	10	-	-	HYPH
cord-337365-hugenn14	317	11	resident	resident	NN
cord-337365-hugenn14	317	12	macrophages	macrophage	NNS
cord-337365-hugenn14	317	13	originate	originate	VBP
cord-337365-hugenn14	317	14	from	from	IN
cord-337365-hugenn14	317	15	yolk	yolk	NN
cord-337365-hugenn14	317	16	-	-	HYPH
cord-337365-hugenn14	317	17	sac	sac	NN
cord-337365-hugenn14	317	18	-	-	HYPH
cord-337365-hugenn14	317	19	derived	derive	VBN
cord-337365-hugenn14	317	20	erythro	erythro	NN
cord-337365-hugenn14	317	21	-	-	HYPH
cord-337365-hugenn14	317	22	myeloid	myeloid	JJ
cord-337365-hugenn14	317	23	progenitors	progenitor	NNS
cord-337365-hugenn14	317	24	Microglial	Microglial	NNP
cord-337365-hugenn14	317	25	physiology	physiology	NN
cord-337365-hugenn14	317	26	and	and	CC
cord-337365-hugenn14	317	27	pathophysiology	pathophysiology	NN
cord-337365-hugenn14	317	28	:	:	:
cord-337365-hugenn14	317	29	insights	insight	NNS
cord-337365-hugenn14	317	30	from	from	IN
cord-337365-hugenn14	317	31	genome	genome	NN
cord-337365-hugenn14	317	32	-	-	HYPH
cord-337365-hugenn14	317	33	wide	wide	JJ
cord-337365-hugenn14	317	34	transcriptional	transcriptional	JJ
cord-337365-hugenn14	317	35	profiling	profiling	NN
cord-337365-hugenn14	317	36	Cytosolic	Cytosolic	NNP
cord-337365-hugenn14	317	37	sensing	sensing	NN
cord-337365-hugenn14	317	38	of	of	IN
cord-337365-hugenn14	317	39	viruses	virus	NNS
cord-337365-hugenn14	317	40	Activation	activation	NN
cord-337365-hugenn14	317	41	and	and	CC
cord-337365-hugenn14	317	42	regulation	regulation	NN
cord-337365-hugenn14	317	43	of	of	IN
cord-337365-hugenn14	317	44	DNA	dna	NN
cord-337365-hugenn14	317	45	-	-	HYPH
cord-337365-hugenn14	317	46	driven	drive	VBN
cord-337365-hugenn14	317	47	immune	immune	JJ
cord-337365-hugenn14	317	48	responses	response	NNS
cord-337365-hugenn14	317	49	Microglia	Microglia	NNP
cord-337365-hugenn14	317	50	control	control	VBP
cord-337365-hugenn14	317	51	the	the	DT
cord-337365-hugenn14	317	52	spread	spread	NN
cord-337365-hugenn14	317	53	of	of	IN
cord-337365-hugenn14	317	54	neurotropic	neurotropic	NNP
cord-337365-hugenn14	317	55	virus	virus	NN
cord-337365-hugenn14	317	56	infection	infection	NN
cord-337365-hugenn14	317	57	via	via	IN
cord-337365-hugenn14	317	58	P2Y12	P2Y12	NNS
cord-337365-hugenn14	317	59	signalling	signal	VBG
cord-337365-hugenn14	317	60	and	and	CC
cord-337365-hugenn14	317	61	recruit	recruit	NN
cord-337365-hugenn14	317	62	monocytes	monocyte	NNS
cord-337365-hugenn14	317	63	through	through	IN
cord-337365-hugenn14	317	64	P2Y12-independent	p2y12-independent	JJ
cord-337365-hugenn14	317	65	mechanisms	mechanism	NNS
cord-337365-hugenn14	317	66	Molecular	molecular	JJ
cord-337365-hugenn14	317	67	physiology	physiology	NN
cord-337365-hugenn14	317	68	of	of	IN
cord-337365-hugenn14	317	69	P2	P2	NNP
cord-337365-hugenn14	317	70	receptors	receptor	NNS
cord-337365-hugenn14	317	71	in	in	IN
cord-337365-hugenn14	317	72	the	the	DT
cord-337365-hugenn14	317	73	central	central	JJ
cord-337365-hugenn14	317	74	nervous	nervous	JJ
cord-337365-hugenn14	317	75	system	system	NN
cord-337365-hugenn14	318	1	Purinergic	Purinergic	NNP
cord-337365-hugenn14	318	2	modulation	modulation	NN
cord-337365-hugenn14	318	3	of	of	IN
cord-337365-hugenn14	318	4	microglial	microglial	JJ
cord-337365-hugenn14	318	5	cell	cell	NN
cord-337365-hugenn14	318	6	activation	activation	NN
cord-337365-hugenn14	319	1	ATP	ATP	NNP
cord-337365-hugenn14	319	2	mediates	mediate	VBZ
cord-337365-hugenn14	319	3	rapid	rapid	JJ
cord-337365-hugenn14	319	4	microglial	microglial	JJ
cord-337365-hugenn14	319	5	response	response	NN
cord-337365-hugenn14	319	6	to	to	IN
cord-337365-hugenn14	319	7	local	local	JJ
cord-337365-hugenn14	319	8	brain	brain	NN
cord-337365-hugenn14	319	9	injury	injury	NN
cord-337365-hugenn14	319	10	in	in	IN
cord-337365-hugenn14	319	11	vivo	vivo	FW
cord-337365-hugenn14	319	12	Dore	Dore	NNP
cord-337365-hugenn14	319	13	S	S	NNP
cord-337365-hugenn14	319	14	role	role	NN
cord-337365-hugenn14	319	15	of	of	IN
cord-337365-hugenn14	319	16	interleukin-10	interleukin-10	NN
cord-337365-hugenn14	319	17	in	in	IN
cord-337365-hugenn14	319	18	acute	acute	JJ
cord-337365-hugenn14	319	19	brain	brain	NN
cord-337365-hugenn14	319	20	injuries	injury	NNS
cord-337365-hugenn14	320	1	Microglia	Microglia	NNP
cord-337365-hugenn14	320	2	are	be	VBP
cord-337365-hugenn14	320	3	required	require	VBN
cord-337365-hugenn14	320	4	for	for	IN
cord-337365-hugenn14	320	5	protection	protection	NN
cord-337365-hugenn14	320	6	against	against	IN
cord-337365-hugenn14	320	7	lethal	lethal	JJ
cord-337365-hugenn14	320	8	coronavirus	coronavirus	NN
cord-337365-hugenn14	320	9	encephalitis	encephalitis	RB
cord-337365-hugenn14	320	10	in	in	IN
cord-337365-hugenn14	320	11	mice	mouse	NNS
cord-337365-hugenn14	320	12	Control	Control	NNP
cord-337365-hugenn14	320	13	of	of	IN
cord-337365-hugenn14	320	14	coronavirus	coronavirus	NN
cord-337365-hugenn14	320	15	infection	infection	NN
cord-337365-hugenn14	320	16	through	through	IN
cord-337365-hugenn14	320	17	plasmacytoid	plasmacytoid	NNP
cord-337365-hugenn14	320	18	dendritic	dendritic	NNP
cord-337365-hugenn14	320	19	-	-	HYPH
cord-337365-hugenn14	320	20	cellderived	cellderived	JJ
cord-337365-hugenn14	320	21	type	type	NN
cord-337365-hugenn14	321	1	I	-PRON-	PRP
cord-337365-hugenn14	321	2	interferon	interferon	RB
cord-337365-hugenn14	322	1	The	the	DT
cord-337365-hugenn14	322	2	brain	brain	NN
cord-337365-hugenn14	322	3	parenchyma	parenchyma	NN
cord-337365-hugenn14	322	4	has	have	VBZ
cord-337365-hugenn14	322	5	a	a	DT
cord-337365-hugenn14	322	6	type	type	NN
cord-337365-hugenn14	323	1	I	-PRON-	PRP
cord-337365-hugenn14	323	2	interferon	interferon	VBD
cord-337365-hugenn14	323	3	response	response	NN
cord-337365-hugenn14	323	4	that	that	WDT
cord-337365-hugenn14	323	5	can	can	MD
cord-337365-hugenn14	323	6	limit	limit	VB
cord-337365-hugenn14	323	7	virus	virus	NN
cord-337365-hugenn14	323	8	spread	spread	VBN
cord-337365-hugenn14	323	9	Mechanisms	mechanism	NNS
cord-337365-hugenn14	323	10	of	of	IN
cord-337365-hugenn14	323	11	type	type	NN
cord-337365-hugenn14	323	12	-	-	HYPH
cord-337365-hugenn14	323	13	I	i	NN
cord-337365-hugenn14	323	14	-	-	HYPH
cord-337365-hugenn14	323	15	and	and	CC
cord-337365-hugenn14	323	16	type	type	NN
cord-337365-hugenn14	323	17	-	-	HYPH
cord-337365-hugenn14	323	18	II	ii	NN
cord-337365-hugenn14	323	19	-	-	HYPH
cord-337365-hugenn14	323	20	interferon	interferon	NN
cord-337365-hugenn14	323	21	-	-	HYPH
cord-337365-hugenn14	323	22	mediated	mediate	VBN
cord-337365-hugenn14	323	23	signalling	signal	VBG
cord-337365-hugenn14	323	24	New	new	JJ
cord-337365-hugenn14	323	25	insights	insight	NNS
cord-337365-hugenn14	323	26	into	into	IN
cord-337365-hugenn14	323	27	innate	innate	JJ
cord-337365-hugenn14	323	28	immune	immune	JJ
cord-337365-hugenn14	323	29	restriction	restriction	NN
cord-337365-hugenn14	323	30	of	of	IN
cord-337365-hugenn14	323	31	West	West	NNP
cord-337365-hugenn14	323	32	Nile	Nile	NNP
cord-337365-hugenn14	323	33	virus	virus	NN
cord-337365-hugenn14	323	34	infection	infection	NN
cord-337365-hugenn14	323	35	Immune	immune	VBP
cord-337365-hugenn14	323	36	sensing	sensing	NN
cord-337365-hugenn14	323	37	of	of	IN
cord-337365-hugenn14	323	38	DNA	DNA	NNP
cord-337365-hugenn14	323	39	Cyclic	Cyclic	NNP
cord-337365-hugenn14	323	40	GMP	GMP	NNP
cord-337365-hugenn14	323	41	-	-	HYPH
cord-337365-hugenn14	323	42	AMP	AMP	NNP
cord-337365-hugenn14	323	43	synthase	synthase	NN
cord-337365-hugenn14	323	44	is	be	VBZ
cord-337365-hugenn14	323	45	a	a	DT
cord-337365-hugenn14	323	46	cytosolic	cytosolic	JJ
cord-337365-hugenn14	323	47	DNA	dna	NN
cord-337365-hugenn14	323	48	sensor	sensor	NN
cord-337365-hugenn14	323	49	that	that	WDT
cord-337365-hugenn14	323	50	activates	activate	VBZ
cord-337365-hugenn14	323	51	the	the	DT
cord-337365-hugenn14	323	52	type	type	NN
cord-337365-hugenn14	324	1	I	-PRON-	PRP
cord-337365-hugenn14	324	2	interferon	interferon	VBD
cord-337365-hugenn14	324	3	pathway	pathway	VBP
cord-337365-hugenn14	324	4	Pathogen	Pathogen	NNP
cord-337365-hugenn14	324	5	recognition	recognition	NN
cord-337365-hugenn14	324	6	and	and	CC
cord-337365-hugenn14	324	7	inflammatory	inflammatory	JJ
cord-337365-hugenn14	324	8	signaling	signaling	NN
cord-337365-hugenn14	324	9	in	in	IN
cord-337365-hugenn14	324	10	innate	innate	JJ
cord-337365-hugenn14	324	11	immune	immune	JJ
cord-337365-hugenn14	324	12	defenses	defense	NNS
cord-337365-hugenn14	324	13	Functional	Functional	NNP
cord-337365-hugenn14	324	14	IRF3	IRF3	NNP
cord-337365-hugenn14	324	15	deficiency	deficiency	NN
cord-337365-hugenn14	324	16	in	in	IN
cord-337365-hugenn14	324	17	a	a	DT
cord-337365-hugenn14	324	18	patient	patient	NN
cord-337365-hugenn14	324	19	with	with	IN
cord-337365-hugenn14	324	20	herpes	herpes	NN
cord-337365-hugenn14	324	21	simplex	simplex	NNP
cord-337365-hugenn14	324	22	encephalitis	encephalitis	RB
cord-337365-hugenn14	325	1	The	the	DT
cord-337365-hugenn14	325	2	host	host	NN
cord-337365-hugenn14	325	3	type	type	NN
cord-337365-hugenn14	326	1	I	-PRON-	PRP
cord-337365-hugenn14	327	1	interferon	interferon	NNP
cord-337365-hugenn14	327	2	response	response	NN
cord-337365-hugenn14	327	3	to	to	IN
cord-337365-hugenn14	327	4	viral	viral	JJ
cord-337365-hugenn14	327	5	and	and	CC
cord-337365-hugenn14	327	6	bacterial	bacterial	JJ
cord-337365-hugenn14	327	7	infections	infection	NNS
cord-337365-hugenn14	327	8	Sensing	sensing	NN
cord-337365-hugenn14	327	9	of	of	IN
cord-337365-hugenn14	327	10	HSV-1	hsv-1	NN
cord-337365-hugenn14	327	11	by	by	IN
cord-337365-hugenn14	327	12	the	the	DT
cord-337365-hugenn14	327	13	cGAS	cgas	JJ
cord-337365-hugenn14	327	14	-	-	HYPH
cord-337365-hugenn14	327	15	STING	sting	NN
cord-337365-hugenn14	327	16	pathway	pathway	NN
cord-337365-hugenn14	327	17	in	in	IN
cord-337365-hugenn14	327	18	microglia	microglia	NNP
cord-337365-hugenn14	327	19	orchestrates	orchestrate	VBZ
cord-337365-hugenn14	327	20	antiviral	antiviral	JJ
cord-337365-hugenn14	327	21	defence	defence	NN
cord-337365-hugenn14	327	22	in	in	IN
cord-337365-hugenn14	327	23	the	the	DT
cord-337365-hugenn14	327	24	CNS	CNS	NNP
cord-337365-hugenn14	327	25	Type	Type	NNP
cord-337365-hugenn14	328	1	I	-PRON-	PRP
cord-337365-hugenn14	328	2	interferon	interferon	VBD
cord-337365-hugenn14	328	3	receptor	receptor	NN
cord-337365-hugenn14	328	4	signaling	signaling	NN
cord-337365-hugenn14	328	5	of	of	IN
cord-337365-hugenn14	328	6	neurons	neuron	NNS
cord-337365-hugenn14	328	7	and	and	CC
cord-337365-hugenn14	328	8	astrocytes	astrocyte	NNS
cord-337365-hugenn14	328	9	regulates	regulate	VBZ
cord-337365-hugenn14	328	10	microglia	microglia	JJ
cord-337365-hugenn14	328	11	activation	activation	NN
cord-337365-hugenn14	328	12	during	during	IN
cord-337365-hugenn14	328	13	viral	viral	JJ
cord-337365-hugenn14	328	14	encephalitis	encephalitis	JJ
cord-337365-hugenn14	328	15	CSF-1R	csf-1r	JJ
cord-337365-hugenn14	328	16	inhibition	inhibition	NN
cord-337365-hugenn14	328	17	alters	alter	VBZ
cord-337365-hugenn14	328	18	macrophage	macrophage	NN
cord-337365-hugenn14	328	19	polarization	polarization	NN
cord-337365-hugenn14	328	20	and	and	CC
cord-337365-hugenn14	328	21	blocks	block	NNS
cord-337365-hugenn14	329	1	glioma	glioma	NN
cord-337365-hugenn14	329	2	progression	progression	NN
cord-337365-hugenn14	329	3	Stroma	Stroma	NNP
cord-337365-hugenn14	329	4	-	-	HYPH
cord-337365-hugenn14	329	5	derived	derive	VBN
cord-337365-hugenn14	329	6	interleukin-34	interleukin-34	NNP
cord-337365-hugenn14	329	7	controls	control	VBZ
cord-337365-hugenn14	329	8	the	the	DT
cord-337365-hugenn14	329	9	development	development	NN
cord-337365-hugenn14	329	10	and	and	CC
cord-337365-hugenn14	329	11	maintenance	maintenance	NN
cord-337365-hugenn14	329	12	of	of	IN
cord-337365-hugenn14	329	13	langerhans	langerhan	NNS
cord-337365-hugenn14	329	14	cells	cell	NNS
cord-337365-hugenn14	329	15	and	and	CC
cord-337365-hugenn14	329	16	the	the	DT
cord-337365-hugenn14	329	17	maintenance	maintenance	NN
cord-337365-hugenn14	329	18	of	of	IN
cord-337365-hugenn14	329	19	microglia	microglia	NNP
cord-337365-hugenn14	330	1	Sall1	Sall1	NNP
cord-337365-hugenn14	330	2	is	be	VBZ
cord-337365-hugenn14	330	3	a	a	DT
cord-337365-hugenn14	330	4	transcriptional	transcriptional	JJ
cord-337365-hugenn14	330	5	regulator	regulator	NN
cord-337365-hugenn14	330	6	defining	define	VBG
cord-337365-hugenn14	330	7	microglia	microglia	JJ
cord-337365-hugenn14	330	8	identity	identity	NN
cord-337365-hugenn14	330	9	and	and	CC
cord-337365-hugenn14	330	10	function	function	VB
cord-337365-hugenn14	330	11	Regional	Regional	NNP
cord-337365-hugenn14	330	12	astrocyte	astrocyte	NN
cord-337365-hugenn14	331	1	IFN	IFN	NNP
cord-337365-hugenn14	331	2	signaling	signal	VBG
cord-337365-hugenn14	331	3	restricts	restrict	VBZ
cord-337365-hugenn14	331	4	pathogenesis	pathogenesis	NN
cord-337365-hugenn14	331	5	during	during	IN
cord-337365-hugenn14	331	6	neurotropic	neurotropic	NNP
cord-337365-hugenn14	331	7	viral	viral	JJ
cord-337365-hugenn14	331	8	infection	infection	NN
cord-337365-hugenn14	331	9	Viral	viral	JJ
cord-337365-hugenn14	331	10	pathogen	pathogen	NN
cord-337365-hugenn14	331	11	-	-	HYPH
cord-337365-hugenn14	331	12	associated	associate	VBN
cord-337365-hugenn14	331	13	molecular	molecular	JJ
cord-337365-hugenn14	331	14	patterns	pattern	NNS
cord-337365-hugenn14	331	15	regulate	regulate	VBP
cord-337365-hugenn14	331	16	blood	blood	NN
cord-337365-hugenn14	331	17	-	-	HYPH
cord-337365-hugenn14	331	18	brain	brain	NN
cord-337365-hugenn14	331	19	barrier	barrier	NN
cord-337365-hugenn14	331	20	integrity	integrity	NN
cord-337365-hugenn14	331	21	via	via	IN
cord-337365-hugenn14	331	22	competing	compete	VBG
cord-337365-hugenn14	331	23	innate	innate	JJ
cord-337365-hugenn14	331	24	cytokine	cytokine	NN
cord-337365-hugenn14	331	25	signals	signal	NNS
cord-337365-hugenn14	331	26	Capture	capture	VBP
cord-337365-hugenn14	331	27	,	,	,
cord-337365-hugenn14	332	1	crawl	crawl	NNP
cord-337365-hugenn14	332	2	,	,	,
cord-337365-hugenn14	332	3	cross	cross	VB
cord-337365-hugenn14	332	4	:	:	:
cord-337365-hugenn14	332	5	the	the	DT
cord-337365-hugenn14	332	6	T	T	NNP
cord-337365-hugenn14	332	7	cell	cell	NN
cord-337365-hugenn14	332	8	code	code	NN
cord-337365-hugenn14	332	9	to	to	TO
cord-337365-hugenn14	332	10	breach	breach	VB
cord-337365-hugenn14	332	11	the	the	DT
cord-337365-hugenn14	332	12	blood	blood	NN
cord-337365-hugenn14	332	13	-	-	HYPH
cord-337365-hugenn14	332	14	brain	brain	NN
cord-337365-hugenn14	332	15	barriers	barrier	NNS
cord-337365-hugenn14	333	1	Interferon	Interferon	NNP
cord-337365-hugenn14	333	2	beta-1b	beta-1b	NNP
cord-337365-hugenn14	333	3	modulates	modulate	VBZ
cord-337365-hugenn14	333	4	serum	serum	NN
cord-337365-hugenn14	333	5	sVCAM-1	sVCAM-1	NNP
cord-337365-hugenn14	333	6	levels	level	NNS
cord-337365-hugenn14	333	7	in	in	IN
cord-337365-hugenn14	333	8	primary	primary	JJ
cord-337365-hugenn14	333	9	progressive	progressive	JJ
cord-337365-hugenn14	333	10	multiple	multiple	JJ
cord-337365-hugenn14	333	11	sclerosis	sclerosis	NN
cord-337365-hugenn14	333	12	Targeted	target	VBN
cord-337365-hugenn14	333	13	blockade	blockade	NN
cord-337365-hugenn14	333	14	in	in	IN
cord-337365-hugenn14	333	15	lethal	lethal	JJ
cord-337365-hugenn14	333	16	West	West	NNP
cord-337365-hugenn14	333	17	Nile	Nile	NNP
cord-337365-hugenn14	333	18	virus	virus	NN
cord-337365-hugenn14	333	19	encephalitis	encephalitis	RB
cord-337365-hugenn14	334	1	indicates	indicate	VBZ
cord-337365-hugenn14	334	2	a	a	DT
cord-337365-hugenn14	334	3	crucial	crucial	JJ
cord-337365-hugenn14	334	4	role	role	NN
cord-337365-hugenn14	334	5	for	for	IN
cord-337365-hugenn14	334	6	very	very	RB
cord-337365-hugenn14	334	7	late	late	JJ
cord-337365-hugenn14	334	8	antigen	antigen	NN
cord-337365-hugenn14	334	9	(	(	-LRB-
cord-337365-hugenn14	334	10	VLA)-4-dependent	vla)-4-dependent	NN
cord-337365-hugenn14	334	11	recruitment	recruitment	NN
cord-337365-hugenn14	334	12	of	of	IN
cord-337365-hugenn14	334	13	nitric	nitric	JJ
cord-337365-hugenn14	334	14	oxide	oxide	NN
cord-337365-hugenn14	334	15	-	-	HYPH
cord-337365-hugenn14	334	16	producing	produce	VBG
cord-337365-hugenn14	334	17	macrophages	macrophage	NNS
cord-337365-hugenn14	334	18	Microglial	Microglial	NNP
cord-337365-hugenn14	334	19	brain	brain	NN
cord-337365-hugenn14	334	20	region	region	NN
cord-337365-hugenn14	334	21	-	-	HYPH
cord-337365-hugenn14	334	22	dependent	dependent	JJ
cord-337365-hugenn14	334	23	diversity	diversity	NN
cord-337365-hugenn14	334	24	and	and	CC
cord-337365-hugenn14	334	25	selective	selective	JJ
cord-337365-hugenn14	334	26	regional	regional	JJ
cord-337365-hugenn14	334	27	sensitivities	sensitivity	NNS
cord-337365-hugenn14	334	28	to	to	IN
cord-337365-hugenn14	334	29	aging	age	VBG
cord-337365-hugenn14	334	30	Cytomegalovirus	Cytomegalovirus	NNP
cord-337365-hugenn14	334	31	induces	induce	VBZ
cord-337365-hugenn14	334	32	cytokine	cytokine	NN
cord-337365-hugenn14	334	33	and	and	CC
cord-337365-hugenn14	334	34	chemokine	chemokine	NN
cord-337365-hugenn14	334	35	production	production	NN
cord-337365-hugenn14	334	36	differentially	differentially	RB
cord-337365-hugenn14	334	37	in	in	IN
cord-337365-hugenn14	334	38	microglia	microglia	NN
cord-337365-hugenn14	334	39	and	and	CC
cord-337365-hugenn14	334	40	astrocytes	astrocyte	NNS
cord-337365-hugenn14	334	41	:	:	:
cord-337365-hugenn14	334	42	antiviral	antiviral	JJ
cord-337365-hugenn14	334	43	implications	implication	NNS
cord-337365-hugenn14	335	1	CXCL10	cxcl10	CD
cord-337365-hugenn14	335	2	production	production	NN
cord-337365-hugenn14	335	3	from	from	IN
cord-337365-hugenn14	335	4	cytomegalovirus	cytomegalovirus	NN
cord-337365-hugenn14	335	5	-	-	HYPH
cord-337365-hugenn14	335	6	stimulated	stimulate	VBN
cord-337365-hugenn14	335	7	microglia	microglia	NNS
cord-337365-hugenn14	335	8	is	be	VBZ
cord-337365-hugenn14	335	9	regulated	regulate	VBN
cord-337365-hugenn14	335	10	by	by	IN
cord-337365-hugenn14	335	11	both	both	DT
cord-337365-hugenn14	335	12	human	human	JJ
cord-337365-hugenn14	335	13	and	and	CC
cord-337365-hugenn14	335	14	viral	viral	JJ
cord-337365-hugenn14	335	15	interleukin-10	interleukin-10	NN
cord-337365-hugenn14	335	16	Robust	robust	JJ
cord-337365-hugenn14	335	17	expression	expression	NN
cord-337365-hugenn14	335	18	of	of	IN
cord-337365-hugenn14	335	19	TNF	tnf	NN
cord-337365-hugenn14	335	20	-	-	HYPH
cord-337365-hugenn14	335	21	alpha	alpha	NN
cord-337365-hugenn14	335	22	,	,	,
cord-337365-hugenn14	335	23	IL-1beta	il-1beta	NN
cord-337365-hugenn14	335	24	,	,	,
cord-337365-hugenn14	335	25	RANTES	RANTES	NNP
cord-337365-hugenn14	335	26	,	,	,
cord-337365-hugenn14	335	27	and	and	CC
cord-337365-hugenn14	335	28	IP-10	IP-10	NNP
cord-337365-hugenn14	335	29	by	by	IN
cord-337365-hugenn14	335	30	human	human	JJ
cord-337365-hugenn14	335	31	microglial	microglial	JJ
cord-337365-hugenn14	335	32	cells	cell	NNS
cord-337365-hugenn14	335	33	during	during	IN
cord-337365-hugenn14	335	34	nonproductive	nonproductive	JJ
cord-337365-hugenn14	335	35	infection	infection	NN
cord-337365-hugenn14	335	36	with	with	IN
cord-337365-hugenn14	335	37	herpes	herpes	NN
cord-337365-hugenn14	335	38	simplex	simplex	NNP
cord-337365-hugenn14	335	39	virus	virus	NN
cord-337365-hugenn14	336	1	Inflammation	inflammation	NN
cord-337365-hugenn14	336	2	-	-	HYPH
cord-337365-hugenn14	336	3	induced	induce	VBN
cord-337365-hugenn14	336	4	,	,	,
cord-337365-hugenn14	336	5	STING	sting	NN
cord-337365-hugenn14	336	6	-	-	HYPH
cord-337365-hugenn14	336	7	dependent	dependent	JJ
cord-337365-hugenn14	336	8	autophagy	autophagy	NN
cord-337365-hugenn14	336	9	restricts	restrict	VBZ
cord-337365-hugenn14	336	10	Zika	Zika	NNP
cord-337365-hugenn14	336	11	virus	virus	NN
cord-337365-hugenn14	336	12	infection	infection	NN
cord-337365-hugenn14	336	13	in	in	IN
cord-337365-hugenn14	336	14	the	the	DT
cord-337365-hugenn14	336	15	Drosophila	drosophila	JJ
cord-337365-hugenn14	336	16	brain	brain	NN
cord-337365-hugenn14	336	17	Immunity	immunity	NN
cord-337365-hugenn14	336	18	in	in	IN
cord-337365-hugenn14	336	19	Drosophila	Drosophila	NNP
cord-337365-hugenn14	336	20	melanogasterfrom	melanogasterfrom	JJ
cord-337365-hugenn14	336	21	microbial	microbial	JJ
cord-337365-hugenn14	336	22	recognition	recognition	NN
cord-337365-hugenn14	336	23	to	to	IN
cord-337365-hugenn14	336	24	whole	whole	JJ
cord-337365-hugenn14	336	25	-	-	HYPH
cord-337365-hugenn14	336	26	organism	organism	NN
cord-337365-hugenn14	336	27	physiology	physiology	NN
cord-337365-hugenn14	336	28	STING	sting	NN
cord-337365-hugenn14	336	29	and	and	CC
cord-337365-hugenn14	336	30	the	the	DT
cord-337365-hugenn14	336	31	innate	innate	JJ
cord-337365-hugenn14	336	32	immune	immune	JJ
cord-337365-hugenn14	336	33	response	response	NN
cord-337365-hugenn14	336	34	to	to	IN
cord-337365-hugenn14	336	35	nucleic	nucleic	JJ
cord-337365-hugenn14	336	36	acids	acid	NNS
cord-337365-hugenn14	336	37	in	in	IN
cord-337365-hugenn14	336	38	the	the	DT
cord-337365-hugenn14	336	39	cytosol	cytosol	NN
cord-337365-hugenn14	337	1	The	the	DT
cord-337365-hugenn14	337	2	parasitophorous	parasitophorous	JJ
cord-337365-hugenn14	337	3	vacuole	vacuole	NN
cord-337365-hugenn14	337	4	membrane	membrane	NN
cord-337365-hugenn14	337	5	of	of	IN
cord-337365-hugenn14	337	6	toxoplasma	toxoplasma	NN
cord-337365-hugenn14	337	7	gondii	gondii	NNP
cord-337365-hugenn14	337	8	is	be	VBZ
cord-337365-hugenn14	337	9	targeted	target	VBN
cord-337365-hugenn14	337	10	for	for	IN
cord-337365-hugenn14	337	11	disruption	disruption	NN
cord-337365-hugenn14	337	12	by	by	IN
cord-337365-hugenn14	337	13	ubiquitin	ubiquitin	NN
cord-337365-hugenn14	337	14	-	-	HYPH
cord-337365-hugenn14	337	15	like	like	JJ
cord-337365-hugenn14	337	16	conjugation	conjugation	NN
cord-337365-hugenn14	337	17	systems	system	NNS
cord-337365-hugenn14	337	18	of	of	IN
cord-337365-hugenn14	337	19	autophagy	autophagy	NN
cord-337365-hugenn14	337	20	Antiviral	antiviral	JJ
cord-337365-hugenn14	337	21	autophagy	autophagy	NN
cord-337365-hugenn14	337	22	restricts	restrict	VBZ
cord-337365-hugenn14	337	23	Rift	Rift	NNP
cord-337365-hugenn14	337	24	Valley	Valley	NNP
cord-337365-hugenn14	337	25	fever	fever	NN
cord-337365-hugenn14	337	26	virus	virus	NN
cord-337365-hugenn14	337	27	infection	infection	NN
cord-337365-hugenn14	337	28	and	and	CC
cord-337365-hugenn14	337	29	is	be	VBZ
cord-337365-hugenn14	337	30	conserved	conserve	VBN
cord-337365-hugenn14	337	31	from	from	IN
cord-337365-hugenn14	337	32	flies	fly	NNS
cord-337365-hugenn14	337	33	to	to	IN
cord-337365-hugenn14	337	34	mammals	mammal	NNS
cord-337365-hugenn14	337	35	STING	sting	VB
cord-337365-hugenn14	337	36	senses	sense	NNS
cord-337365-hugenn14	337	37	microbial	microbial	JJ
cord-337365-hugenn14	337	38	viability	viability	NN
cord-337365-hugenn14	337	39	to	to	TO
cord-337365-hugenn14	337	40	orchestrate	orchestrate	VB
cord-337365-hugenn14	337	41	stress	stress	NN
cord-337365-hugenn14	337	42	-	-	HYPH
cord-337365-hugenn14	337	43	mediated	mediate	VBN
cord-337365-hugenn14	337	44	autophagy	autophagy	NN
cord-337365-hugenn14	337	45	of	of	IN
cord-337365-hugenn14	337	46	the	the	DT
cord-337365-hugenn14	337	47	endoplasmic	endoplasmic	NN
cord-337365-hugenn14	337	48	reticulum	reticulum	NN
cord-337365-hugenn14	337	49	Autophagy	Autophagy	NNP
cord-337365-hugenn14	337	50	in	in	IN
cord-337365-hugenn14	337	51	immunity	immunity	NN
cord-337365-hugenn14	337	52	and	and	CC
cord-337365-hugenn14	337	53	inflammation	inflammation	NN
cord-337365-hugenn14	337	54	Role	role	NN
cord-337365-hugenn14	337	55	and	and	CC
cord-337365-hugenn14	337	56	regulation	regulation	NN
cord-337365-hugenn14	337	57	starvation	starvation	NN
cord-337365-hugenn14	337	58	-	-	HYPH
cord-337365-hugenn14	337	59	induced	induce	VBN
cord-337365-hugenn14	337	60	autophagy	autophagy	NN
cord-337365-hugenn14	337	61	in	in	IN
cord-337365-hugenn14	337	62	the	the	DT
cord-337365-hugenn14	337	63	Drosophila	drosophila	JJ
cord-337365-hugenn14	337	64	fat	fat	JJ
cord-337365-hugenn14	337	65	body	body	NN
cord-337365-hugenn14	337	66	Signal	Signal	NNP
cord-337365-hugenn14	337	67	integration	integration	NN
cord-337365-hugenn14	337	68	by	by	IN
cord-337365-hugenn14	337	69	the	the	DT
cord-337365-hugenn14	337	70	IkB	IkB	NNP
cord-337365-hugenn14	337	71	protein	protein	NN
cord-337365-hugenn14	337	72	pickle	pickle	NN
cord-337365-hugenn14	337	73	shapes	shape	VBZ
cord-337365-hugenn14	337	74	Drosophila	Drosophila	NNP
cord-337365-hugenn14	337	75	innate	innate	JJ
cord-337365-hugenn14	337	76	host	host	NN
cord-337365-hugenn14	337	77	defense	defense	NN
cord-337365-hugenn14	337	78	Chikungunya	Chikungunya	NNP
cord-337365-hugenn14	337	79	virus	virus	NN
cord-337365-hugenn14	337	80	-	-	HYPH
cord-337365-hugenn14	337	81	induced	induce	VBN
cord-337365-hugenn14	337	82	autophagy	autophagy	NN
cord-337365-hugenn14	337	83	delays	delay	NNS
cord-337365-hugenn14	337	84	caspase	caspase	NN
cord-337365-hugenn14	337	85	-	-	HYPH
cord-337365-hugenn14	337	86	dependent	dependent	JJ
cord-337365-hugenn14	337	87	cell	cell	NN
cord-337365-hugenn14	337	88	death	death	NN
cord-337365-hugenn14	337	89	Immune	immune	NN
cord-337365-hugenn14	337	90	signaling	signal	VBG
cord-337365-hugenn14	337	91	by	by	IN
cord-337365-hugenn14	337	92	RIG	rig	NN
cord-337365-hugenn14	337	93	-	-	HYPH
cord-337365-hugenn14	337	94	I	i	NN
cord-337365-hugenn14	337	95	-	-	HYPH
cord-337365-hugenn14	337	96	like	like	JJ
cord-337365-hugenn14	337	97	receptors	receptor	NNS
cord-337365-hugenn14	337	98	Virus	virus	NN
cord-337365-hugenn14	337	99	recognition	recognition	NN
cord-337365-hugenn14	337	100	by	by	IN
cord-337365-hugenn14	337	101	Toll-7	Toll-7	NNP
cord-337365-hugenn14	337	102	activates	activate	VBZ
cord-337365-hugenn14	337	103	antiviral	antiviral	JJ
cord-337365-hugenn14	337	104	autophagy	autophagy	NN
cord-337365-hugenn14	337	105	in	in	IN
cord-337365-hugenn14	337	106	Drosophila	Drosophila	NNP
cord-337365-hugenn14	337	107	Neurologic	neurologic	JJ
cord-337365-hugenn14	337	108	manifestations	manifestation	NNS
cord-337365-hugenn14	337	109	and	and	CC
cord-337365-hugenn14	337	110	outcome	outcome	NN
cord-337365-hugenn14	337	111	of	of	IN
cord-337365-hugenn14	337	112	West	West	NNP
cord-337365-hugenn14	337	113	Nile	Nile	NNP
cord-337365-hugenn14	337	114	virus	virus	NN
cord-337365-hugenn14	337	115	infection	infection	NN
cord-337365-hugenn14	337	116	Persistent	persistent	JJ
cord-337365-hugenn14	337	117	neuropsychological	neuropsychological	JJ
cord-337365-hugenn14	337	118	impairment	impairment	NN
cord-337365-hugenn14	337	119	associated	associate	VBN
cord-337365-hugenn14	337	120	with	with	IN
cord-337365-hugenn14	337	121	West	West	NNP
cord-337365-hugenn14	337	122	Nile	Nile	NNP
cord-337365-hugenn14	337	123	virus	virus	NN
cord-337365-hugenn14	337	124	infection	infection	NN
cord-337365-hugenn14	337	125	A	a	DT
cord-337365-hugenn14	337	126	complement	complement	NN
cord-337365-hugenn14	337	127	-	-	HYPH
cord-337365-hugenn14	337	128	microglial	microglial	JJ
cord-337365-hugenn14	337	129	axis	axis	NN
cord-337365-hugenn14	338	1	drives	drive	VBZ
cord-337365-hugenn14	338	2	synapse	synapse	NNP
cord-337365-hugenn14	338	3	loss	loss	NN
cord-337365-hugenn14	338	4	during	during	IN
cord-337365-hugenn14	338	5	virus	virus	NN
cord-337365-hugenn14	338	6	-	-	HYPH
cord-337365-hugenn14	338	7	induced	induce	VBN
cord-337365-hugenn14	338	8	memory	memory	NN
cord-337365-hugenn14	338	9	impairment	impairment	NN
cord-337365-hugenn14	338	10	In	in	IN
cord-337365-hugenn14	338	11	vivo	vivo	NN
cord-337365-hugenn14	338	12	visualization	visualization	NN
cord-337365-hugenn14	338	13	of	of	IN
cord-337365-hugenn14	338	14	activated	activate	VBN
cord-337365-hugenn14	338	15	glia	glia	NNS
cord-337365-hugenn14	338	16	by	by	IN
cord-337365-hugenn14	338	17	[	[	-LRB-
cord-337365-hugenn14	338	18	11C	11c	CD
cord-337365-hugenn14	338	19	]	]	-RRB-
cord-337365-hugenn14	339	1	(	(	-LRB-
cord-337365-hugenn14	339	2	R)-PK11195-PET	R)-PK11195-PET	``
cord-337365-hugenn14	339	3	following	follow	VBG
cord-337365-hugenn14	339	4	herpes	herpes	NNP
cord-337365-hugenn14	339	5	encephalitis	encephalitis	NN
cord-337365-hugenn14	339	6	reveals	reveal	VBZ
cord-337365-hugenn14	339	7	projected	project	VBN
cord-337365-hugenn14	339	8	neuronal	neuronal	JJ
cord-337365-hugenn14	339	9	damage	damage	NN
cord-337365-hugenn14	339	10	beyond	beyond	IN
cord-337365-hugenn14	339	11	the	the	DT
cord-337365-hugenn14	339	12	primary	primary	JJ
cord-337365-hugenn14	339	13	focal	focal	JJ
cord-337365-hugenn14	339	14	lesion	lesion	NN
cord-337365-hugenn14	340	1	Neuroinflammatory	Neuroinflammatory	NNP
cord-337365-hugenn14	340	2	TNFa	TNFa	NNP
cord-337365-hugenn14	340	3	impairs	impair	VBZ
cord-337365-hugenn14	340	4	memory	memory	NN
cord-337365-hugenn14	340	5	via	via	IN
cord-337365-hugenn14	340	6	astrocyte	astrocyte	NNP
cord-337365-hugenn14	340	7	signaling	signal	VBG
cord-337365-hugenn14	340	8	TNFa	TNFa	NNP
cord-337365-hugenn14	340	9	controls	control	VBZ
cord-337365-hugenn14	340	10	glutamatergic	glutamatergic	JJ
cord-337365-hugenn14	340	11	gliotransmission	gliotransmission	NN
cord-337365-hugenn14	340	12	in	in	IN
cord-337365-hugenn14	340	13	the	the	DT
cord-337365-hugenn14	340	14	hippocampal	hippocampal	JJ
cord-337365-hugenn14	340	15	dentate	dentate	NN
cord-337365-hugenn14	340	16	gyrus	gyrus	NNP
cord-337365-hugenn14	340	17	Zika	Zika	NNP
cord-337365-hugenn14	340	18	virus	virus	NN
cord-337365-hugenn14	340	19	infection	infection	NN
cord-337365-hugenn14	340	20	in	in	IN
cord-337365-hugenn14	340	21	pregnant	pregnant	JJ
cord-337365-hugenn14	340	22	women	woman	NNS
cord-337365-hugenn14	340	23	in	in	IN
cord-337365-hugenn14	340	24	Rio	Rio	NNP
cord-337365-hugenn14	340	25	de	de	NNP
cord-337365-hugenn14	340	26	Janeiro	Janeiro	NNP
cord-337365-hugenn14	340	27	Microcephaly	Microcephaly	NNP
cord-337365-hugenn14	340	28	associated	associate	VBD
cord-337365-hugenn14	340	29	with	with	IN
cord-337365-hugenn14	340	30	maternal	maternal	JJ
cord-337365-hugenn14	340	31	Zika	Zika	NNP
cord-337365-hugenn14	340	32	virus	virus	NN
cord-337365-hugenn14	340	33	infection	infection	NN
cord-337365-hugenn14	340	34	Guillain	Guillain	NNP
cord-337365-hugenn14	340	35	-	-	HYPH
cord-337365-hugenn14	340	36	Barré	Barré	NNP
cord-337365-hugenn14	340	37	syndrome	syndrome	NN
cord-337365-hugenn14	340	38	outbreak	outbreak	NN
cord-337365-hugenn14	340	39	associated	associate	VBN
cord-337365-hugenn14	340	40	with	with	IN
cord-337365-hugenn14	340	41	Zika	Zika	NNP
cord-337365-hugenn14	340	42	virus	virus	NN
cord-337365-hugenn14	340	43	infection	infection	NN
cord-337365-hugenn14	340	44	in	in	IN
cord-337365-hugenn14	340	45	French	French	NNP
cord-337365-hugenn14	340	46	Polynesia	Polynesia	NNP
cord-337365-hugenn14	340	47	:	:	:
cord-337365-hugenn14	340	48	a	a	DT
cord-337365-hugenn14	340	49	case	case	NN
cord-337365-hugenn14	340	50	-	-	HYPH
cord-337365-hugenn14	340	51	control	control	NN
cord-337365-hugenn14	340	52	study	study	NN
cord-337365-hugenn14	340	53	Zika	Zika	NNP
cord-337365-hugenn14	340	54	virus	virus	NN
cord-337365-hugenn14	340	55	and	and	CC
cord-337365-hugenn14	340	56	birth	birth	NN
cord-337365-hugenn14	340	57	defects	defect	NNS
cord-337365-hugenn14	340	58	-	-	,
cord-337365-hugenn14	340	59	reviewing	review	VBG
cord-337365-hugenn14	340	60	the	the	DT
cord-337365-hugenn14	340	61	evidence	evidence	NN
cord-337365-hugenn14	340	62	for	for	IN
cord-337365-hugenn14	340	63	causality	causality	NN
cord-337365-hugenn14	340	64	Zika	Zika	NNP
cord-337365-hugenn14	340	65	virus	virus	NN
cord-337365-hugenn14	340	66	associated	associate	VBN
cord-337365-hugenn14	340	67	with	with	IN
cord-337365-hugenn14	340	68	microcephaly	microcephaly	NNS
cord-337365-hugenn14	340	69	Zika	Zika	NNP
cord-337365-hugenn14	340	70	virus	virus	NN
cord-337365-hugenn14	340	71	infects	infect	VBZ
cord-337365-hugenn14	340	72	human	human	JJ
cord-337365-hugenn14	340	73	fetal	fetal	JJ
cord-337365-hugenn14	340	74	brain	brain	NN
cord-337365-hugenn14	340	75	microglia	microglia	NNS
cord-337365-hugenn14	340	76	and	and	CC
cord-337365-hugenn14	340	77	induces	induce	VBZ
cord-337365-hugenn14	340	78	inflammation	inflammation	NN
cord-337365-hugenn14	340	79	Microglia	Microglia	NNP
cord-337365-hugenn14	340	80	-	-	HYPH
cord-337365-hugenn14	340	81	blood	blood	NN
cord-337365-hugenn14	340	82	vessel	vessel	NN
cord-337365-hugenn14	340	83	interactions	interaction	NNS
cord-337365-hugenn14	340	84	:	:	:
cord-337365-hugenn14	340	85	a	a	DT
cord-337365-hugenn14	340	86	double	double	RB
cord-337365-hugenn14	340	87	-	-	HYPH
cord-337365-hugenn14	340	88	edged	edged	JJ
cord-337365-hugenn14	340	89	sword	sword	NN
cord-337365-hugenn14	340	90	in	in	IN
cord-337365-hugenn14	340	91	brain	brain	NN
cord-337365-hugenn14	340	92	pathologies	pathology	NNS
cord-337365-hugenn14	341	1	Human	human	JJ
cord-337365-hugenn14	341	2	brain	brain	NN
cord-337365-hugenn14	341	3	parenchymal	parenchymal	NN
cord-337365-hugenn14	341	4	microglia	microglia	NN
cord-337365-hugenn14	341	5	express	express	VBP
cord-337365-hugenn14	341	6	CD14	CD14	NNP
cord-337365-hugenn14	341	7	and	and	CC
cord-337365-hugenn14	341	8	CD45	CD45	NNP
cord-337365-hugenn14	341	9	and	and	CC
cord-337365-hugenn14	341	10	are	be	VBP
cord-337365-hugenn14	341	11	productively	productively	RB
cord-337365-hugenn14	341	12	infected	infect	VBN
cord-337365-hugenn14	341	13	by	by	IN
cord-337365-hugenn14	341	14	HIV-1	HIV-1	NNP
cord-337365-hugenn14	341	15	in	in	IN
cord-337365-hugenn14	341	16	HIV-1	HIV-1	NNP
cord-337365-hugenn14	341	17	encephalitis	encephalitis	NN
cord-337365-hugenn14	341	18	Central	central	JJ
cord-337365-hugenn14	341	19	nervous	nervous	JJ
cord-337365-hugenn14	341	20	system	system	NN
cord-337365-hugenn14	341	21	damage	damage	NN
cord-337365-hugenn14	341	22	,	,	,
cord-337365-hugenn14	341	23	monocytes	monocyte	NNS
cord-337365-hugenn14	341	24	and	and	CC
cord-337365-hugenn14	341	25	macrophages	macrophage	NNS
cord-337365-hugenn14	341	26	,	,	,
cord-337365-hugenn14	341	27	and	and	CC
cord-337365-hugenn14	341	28	neurological	neurological	JJ
cord-337365-hugenn14	341	29	disorders	disorder	NNS
cord-337365-hugenn14	341	30	in	in	IN
cord-337365-hugenn14	341	31	AIDS	AIDS	NNP
cord-337365-hugenn14	341	32	Mononuclear	Mononuclear	NNP
cord-337365-hugenn14	342	1	phagocyte	phagocyte	NNP
cord-337365-hugenn14	342	2	immunity	immunity	NN
cord-337365-hugenn14	342	3	and	and	CC
cord-337365-hugenn14	342	4	the	the	DT
cord-337365-hugenn14	342	5	neuropathogenesis	neuropathogenesis	NN
cord-337365-hugenn14	342	6	of	of	IN
cord-337365-hugenn14	342	7	HIV-1	HIV-1	NNP
cord-337365-hugenn14	342	8	infection	infection	NN
cord-337365-hugenn14	342	9	Regulated	regulated	JJ
cord-337365-hugenn14	342	10	expression	expression	NN
cord-337365-hugenn14	342	11	of	of	IN
cord-337365-hugenn14	342	12	sodium	sodium	NN
cord-337365-hugenn14	342	13	-	-	HYPH
cord-337365-hugenn14	342	14	dependent	dependent	JJ
cord-337365-hugenn14	342	15	glutamate	glutamate	NN
cord-337365-hugenn14	342	16	transporters	transporter	NNS
cord-337365-hugenn14	342	17	and	and	CC
cord-337365-hugenn14	342	18	synthetase	synthetase	NN
cord-337365-hugenn14	342	19	:	:	:
cord-337365-hugenn14	342	20	a	a	DT
cord-337365-hugenn14	342	21	neuroprotective	neuroprotective	JJ
cord-337365-hugenn14	342	22	role	role	NN
cord-337365-hugenn14	342	23	for	for	IN
cord-337365-hugenn14	342	24	activated	activate	VBN
cord-337365-hugenn14	342	25	microglia	microglia	NNS
cord-337365-hugenn14	342	26	and	and	CC
cord-337365-hugenn14	342	27	macrophages	macrophage	NNS
cord-337365-hugenn14	342	28	in	in	IN
cord-337365-hugenn14	342	29	HIV	HIV	NNP
cord-337365-hugenn14	342	30	infection	infection	NN
cord-337365-hugenn14	342	31	?	?	.
cord-337365-hugenn14	343	1	Decreased	decrease	VBN
cord-337365-hugenn14	343	2	neuronal	neuronal	JJ
cord-337365-hugenn14	343	3	autophagy	autophagy	NN
cord-337365-hugenn14	343	4	in	in	IN
cord-337365-hugenn14	343	5	HIV	HIV	NNP
cord-337365-hugenn14	343	6	dementia	dementia	NN
cord-337365-hugenn14	343	7	:	:	:
cord-337365-hugenn14	344	1	a	a	DT
cord-337365-hugenn14	344	2	mechanism	mechanism	NN
cord-337365-hugenn14	344	3	of	of	IN
cord-337365-hugenn14	344	4	indirect	indirect	JJ
cord-337365-hugenn14	344	5	neurotoxicity	neurotoxicity	NN
cord-337365-hugenn14	344	6	Expression	Expression	NNP
cord-337365-hugenn14	344	7	profiling	profiling	NN
cord-337365-hugenn14	344	8	suggests	suggest	VBZ
cord-337365-hugenn14	344	9	microglial	microglial	JJ
cord-337365-hugenn14	344	10	impairment	impairment	NN
cord-337365-hugenn14	344	11	in	in	IN
cord-337365-hugenn14	344	12	HIV	HIV	NNP
cord-337365-hugenn14	344	13	neuropathogenesis	neuropathogenesis	NN
cord-337365-hugenn14	344	14	Cytomegalovirus	Cytomegalovirus	NNP
cord-337365-hugenn14	344	15	encephalitis	encephalitis	NN
cord-337365-hugenn14	344	16	Microglial	Microglial	NNP
cord-337365-hugenn14	344	17	nodular	nodular	JJ
cord-337365-hugenn14	344	18	encephalitis	encephalitis	NN
cord-337365-hugenn14	344	19	and	and	CC
cord-337365-hugenn14	344	20	ventriculoencephalitis	ventriculoencephalitis	NN
cord-337365-hugenn14	344	21	due	due	IN
cord-337365-hugenn14	344	22	to	to	IN
cord-337365-hugenn14	344	23	cytomegalovirus	cytomegalovirus	NN
cord-337365-hugenn14	344	24	in	in	IN
cord-337365-hugenn14	344	25	patients	patient	NNS
cord-337365-hugenn14	344	26	with	with	IN
cord-337365-hugenn14	344	27	AIDS	AIDS	NNP
cord-337365-hugenn14	344	28	:	:	:
cord-337365-hugenn14	344	29	two	two	CD
cord-337365-hugenn14	344	30	distinct	distinct	JJ
cord-337365-hugenn14	344	31	clinical	clinical	JJ
cord-337365-hugenn14	344	32	patterns	pattern	NNS
cord-337365-hugenn14	344	33	Acta	Acta	NNP
cord-337365-hugenn14	344	34	Neuropathol	Neuropathol	NNP
cord-337365-hugenn14	345	1	:	:	:
cord-337365-hugenn14	345	2	Microglial	Microglial	NNP
cord-337365-hugenn14	345	3	nodules	nodule	NNS
cord-337365-hugenn14	345	4	provide	provide	VBP
cord-337365-hugenn14	345	5	the	the	DT
cord-337365-hugenn14	345	6	environment	environment	NN
cord-337365-hugenn14	345	7	for	for	IN
cord-337365-hugenn14	345	8	pathogenic	pathogenic	JJ
cord-337365-hugenn14	345	9	T	t	NN
cord-337365-hugenn14	345	10	cells	cell	NNS
cord-337365-hugenn14	345	11	in	in	IN
cord-337365-hugenn14	345	12	human	human	JJ
cord-337365-hugenn14	345	13	encephalitis	encephalitis	NN
cord-337365-hugenn14	346	1	Peli1	peli1	NN
cord-337365-hugenn14	346	2	facilitates	facilitate	VBZ
cord-337365-hugenn14	346	3	virus	virus	NN
cord-337365-hugenn14	346	4	replication	replication	NN
cord-337365-hugenn14	346	5	and	and	CC
cord-337365-hugenn14	346	6	promotes	promote	VBZ
cord-337365-hugenn14	346	7	neuroinflammation	neuroinflammation	NN
cord-337365-hugenn14	346	8	during	during	IN
cord-337365-hugenn14	346	9	West	West	NNP
cord-337365-hugenn14	346	10	Nile	Nile	NNP
cord-337365-hugenn14	346	11	virus	virus	NN
cord-337365-hugenn14	346	12	infection	infection	NN
cord-337365-hugenn14	346	13	Differential	differential	JJ
cord-337365-hugenn14	346	14	responses	response	NNS
cord-337365-hugenn14	346	15	of	of	IN
cord-337365-hugenn14	346	16	human	human	JJ
cord-337365-hugenn14	346	17	brain	brain	NN
cord-337365-hugenn14	346	18	cells	cell	NNS
cord-337365-hugenn14	346	19	to	to	IN
cord-337365-hugenn14	346	20	West	West	NNP
cord-337365-hugenn14	346	21	Nile	Nile	NNP
cord-337365-hugenn14	346	22	virus	virus	NN
cord-337365-hugenn14	346	23	infection	infection	NN
cord-337365-hugenn14	347	1	Peli1	Peli1	NNP
cord-337365-hugenn14	347	2	promotes	promote	VBZ
cord-337365-hugenn14	347	3	microglia	microglia	NN
cord-337365-hugenn14	347	4	-	-	HYPH
cord-337365-hugenn14	347	5	mediated	mediate	VBN
cord-337365-hugenn14	347	6	CNS	CNS	NNP
cord-337365-hugenn14	347	7	inflammation	inflammation	NN
cord-337365-hugenn14	347	8	by	by	IN
cord-337365-hugenn14	347	9	regulating	regulate	VBG
cord-337365-hugenn14	347	10	Traf3	traf3	JJ
cord-337365-hugenn14	347	11	degradation	degradation	NN
cord-337365-hugenn14	348	1	Microglia	Microglia	NNP
cord-337365-hugenn14	348	2	recognize	recognize	VBP
cord-337365-hugenn14	348	3	double	double	RB
cord-337365-hugenn14	348	4	-	-	HYPH
cord-337365-hugenn14	348	5	stranded	strand	VBN
cord-337365-hugenn14	348	6	RNA	RNA	NNP
cord-337365-hugenn14	348	7	via	via	IN
cord-337365-hugenn14	348	8	TLR3	TLR3	NNP
cord-337365-hugenn14	348	9	Protective	protective	JJ
cord-337365-hugenn14	348	10	effect	effect	NN
cord-337365-hugenn14	348	11	of	of	IN
cord-337365-hugenn14	348	12	amyloid	amyloid	NN
cord-337365-hugenn14	348	13	-	-	HYPH
cord-337365-hugenn14	348	14	β	β	NN
cord-337365-hugenn14	348	15	peptides	peptide	NNS
cord-337365-hugenn14	348	16	against	against	IN
cord-337365-hugenn14	348	17	herpes	herpes	NN
cord-337365-hugenn14	348	18	simplex	simplex	NNP
cord-337365-hugenn14	348	19	Virus-1	Virus-1	NNP
cord-337365-hugenn14	348	20	infection	infection	NN
cord-337365-hugenn14	348	21	in	in	IN
cord-337365-hugenn14	348	22	a	a	DT
cord-337365-hugenn14	348	23	neuronal	neuronal	JJ
cord-337365-hugenn14	348	24	cell	cell	NN
cord-337365-hugenn14	348	25	culture	culture	NN
cord-337365-hugenn14	348	26	model	model	NN
cord-337365-hugenn14	349	1	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	349	2	's	's	POS
cord-337365-hugenn14	349	3	disease	disease	NN
cord-337365-hugenn14	349	4	-	-	HYPH
cord-337365-hugenn14	349	5	associated	associate	VBN
cord-337365-hugenn14	349	6	β	β	NN
cord-337365-hugenn14	349	7	-	-	HYPH
cord-337365-hugenn14	349	8	amyloid	amyloid	NN
cord-337365-hugenn14	349	9	is	be	VBZ
cord-337365-hugenn14	349	10	rapidly	rapidly	RB
cord-337365-hugenn14	349	11	seeded	seed	VBN
cord-337365-hugenn14	349	12	by	by	IN
cord-337365-hugenn14	349	13	herpesviridae	herpesviridae	NN
cord-337365-hugenn14	349	14	to	to	TO
cord-337365-hugenn14	349	15	protect	protect	VB
cord-337365-hugenn14	349	16	against	against	IN
cord-337365-hugenn14	349	17	brain	brain	NN
cord-337365-hugenn14	349	18	infection	infection	NN
cord-337365-hugenn14	349	19	Anti	anti	JJ
cord-337365-hugenn14	349	20	-	-	JJ
cord-337365-hugenn14	349	21	herpetic	herpetic	JJ
cord-337365-hugenn14	349	22	medications	medication	NNS
cord-337365-hugenn14	349	23	and	and	CC
cord-337365-hugenn14	349	24	reduced	reduce	VBN
cord-337365-hugenn14	349	25	risk	risk	NN
cord-337365-hugenn14	349	26	of	of	IN
cord-337365-hugenn14	349	27	dementia	dementia	NN
cord-337365-hugenn14	349	28	in	in	IN
cord-337365-hugenn14	349	29	patients	patient	NNS
cord-337365-hugenn14	349	30	with	with	IN
cord-337365-hugenn14	349	31	herpes	herpes	NN
cord-337365-hugenn14	349	32	simplex	simplex	NNP
cord-337365-hugenn14	349	33	virus	virus	NN
cord-337365-hugenn14	349	34	infections	infection	NNS
cord-337365-hugenn14	349	35	-	-	:
cord-337365-hugenn14	349	36	a	a	DT
cord-337365-hugenn14	349	37	Nationwide	Nationwide	NNP
cord-337365-hugenn14	349	38	.	.	.
cord-337365-hugenn14	350	1	Population	population	NN
cord-337365-hugenn14	350	2	-	-	HYPH
cord-337365-hugenn14	350	3	Based	Based	NNP
cord-337365-hugenn14	350	4	Cohort	Cohort	NNP
cord-337365-hugenn14	350	5	Study	Study	NNP
cord-337365-hugenn14	350	6	in	in	IN
cord-337365-hugenn14	350	7	Taiwan	Taiwan	NNP
cord-337365-hugenn14	351	1	Neurotherapeutics	Neurotherapeutics	NNP
cord-337365-hugenn14	351	2	Microglia	Microglia	NNP
cord-337365-hugenn14	351	3	activation	activation	NN
cord-337365-hugenn14	351	4	and	and	CC
cord-337365-hugenn14	351	5	antiinflammatory	antiinflammatory	JJ
cord-337365-hugenn14	351	6	regulation	regulation	NN
cord-337365-hugenn14	351	7	in	in	IN
cord-337365-hugenn14	351	8	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	351	9	's	's	POS
cord-337365-hugenn14	351	10	disease	disease	NN
cord-337365-hugenn14	352	1	Microglia	Microglia	NNP
cord-337365-hugenn14	352	2	promote	promote	VBP
cord-337365-hugenn14	352	3	learning	learn	VBG
cord-337365-hugenn14	352	4	dependent	dependent	JJ
cord-337365-hugenn14	352	5	synapse	synapse	NN
cord-337365-hugenn14	352	6	formation	formation	NN
cord-337365-hugenn14	352	7	through	through	IN
cord-337365-hugenn14	352	8	brain	brain	NN
cord-337365-hugenn14	352	9	-	-	HYPH
cord-337365-hugenn14	352	10	derived	derive	VBN
cord-337365-hugenn14	352	11	neurotrophic	neurotrophic	NN
cord-337365-hugenn14	352	12	factor	factor	NN
cord-337365-hugenn14	353	1	A	a	DT
cord-337365-hugenn14	353	2	unique	unique	JJ
cord-337365-hugenn14	353	3	microglia	microglia	JJ
cord-337365-hugenn14	353	4	type	type	NN
cord-337365-hugenn14	353	5	associated	associate	VBN
cord-337365-hugenn14	353	6	with	with	IN
cord-337365-hugenn14	353	7	restricting	restrict	VBG
cord-337365-hugenn14	353	8	development	development	NN
cord-337365-hugenn14	353	9	of	of	IN
cord-337365-hugenn14	353	10	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	353	11	's	's	POS
cord-337365-hugenn14	353	12	disease	disease	NN
cord-337365-hugenn14	354	1	TREM2	TREM2	NNP
cord-337365-hugenn14	354	2	deficiency	deficiency	NN
cord-337365-hugenn14	354	3	impairs	impair	VBZ
cord-337365-hugenn14	354	4	chemotaxis	chemotaxis	NN
cord-337365-hugenn14	354	5	and	and	CC
cord-337365-hugenn14	354	6	microglial	microglial	JJ
cord-337365-hugenn14	354	7	responses	response	NNS
cord-337365-hugenn14	354	8	to	to	IN
cord-337365-hugenn14	354	9	neuronal	neuronal	JJ
cord-337365-hugenn14	354	10	injury	injury	NN
cord-337365-hugenn14	355	1	TREM2	TREM2	NNP
cord-337365-hugenn14	355	2	maintains	maintain	VBZ
cord-337365-hugenn14	355	3	microglial	microglial	JJ
cord-337365-hugenn14	355	4	metabolic	metabolic	JJ
cord-337365-hugenn14	355	5	fitness	fitness	NN
cord-337365-hugenn14	355	6	in	in	IN
cord-337365-hugenn14	355	7	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	355	8	's	's	POS
cord-337365-hugenn14	355	9	disease	disease	NN
cord-337365-hugenn14	356	1	TREM2-mediated	trem2-mediated	DT
cord-337365-hugenn14	356	2	early	early	JJ
cord-337365-hugenn14	356	3	microglial	microglial	JJ
cord-337365-hugenn14	356	4	response	response	NN
cord-337365-hugenn14	356	5	limits	limit	VBZ
cord-337365-hugenn14	356	6	diffusion	diffusion	NN
cord-337365-hugenn14	356	7	and	and	CC
cord-337365-hugenn14	356	8	toxicity	toxicity	NN
cord-337365-hugenn14	356	9	of	of	IN
cord-337365-hugenn14	356	10	amyloid	amyloid	NN
cord-337365-hugenn14	356	11	plaques	plaque	NNS
cord-337365-hugenn14	356	12	TREM2	TREM2	NNP
cord-337365-hugenn14	356	13	haplodeficiency	haplodeficiency	NN
cord-337365-hugenn14	356	14	in	in	IN
cord-337365-hugenn14	356	15	mice	mouse	NNS
cord-337365-hugenn14	356	16	and	and	CC
cord-337365-hugenn14	357	1	humans	human	NNS
cord-337365-hugenn14	357	2	impairs	impair	VBZ
cord-337365-hugenn14	357	3	the	the	DT
cord-337365-hugenn14	357	4	microglia	microglia	JJ
cord-337365-hugenn14	357	5	barrier	barrier	NN
cord-337365-hugenn14	357	6	function	function	NN
cord-337365-hugenn14	357	7	leading	lead	VBG
cord-337365-hugenn14	357	8	to	to	IN
cord-337365-hugenn14	357	9	decreased	decrease	VBN
cord-337365-hugenn14	357	10	amyloid	amyloid	NN
cord-337365-hugenn14	357	11	compaction	compaction	NN
cord-337365-hugenn14	357	12	and	and	CC
cord-337365-hugenn14	358	1	severe	severe	JJ
cord-337365-hugenn14	358	2	axonal	axonal	JJ
cord-337365-hugenn14	358	3	dystrophy	dystrophy	NN
cord-337365-hugenn14	358	4	Microglia	Microglia	NNP
cord-337365-hugenn14	358	5	-	-	HYPH
cord-337365-hugenn14	358	6	derived	derive	VBN
cord-337365-hugenn14	358	7	ASC	ASC	NNP
cord-337365-hugenn14	358	8	specks	speck	NNS
cord-337365-hugenn14	358	9	cross	cross	VBP
cord-337365-hugenn14	358	10	seed	seed	NN
cord-337365-hugenn14	358	11	amyloid	amyloid	NN
cord-337365-hugenn14	358	12	-	-	HYPH
cord-337365-hugenn14	358	13	beta	beta	NN
cord-337365-hugenn14	358	14	in	in	IN
cord-337365-hugenn14	358	15	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	358	16	's	's	POS
cord-337365-hugenn14	358	17	disease	disease	NN
cord-337365-hugenn14	358	18	Complement	complement	NN
cord-337365-hugenn14	358	19	and	and	CC
cord-337365-hugenn14	358	20	microglia	microglia	NN
cord-337365-hugenn14	358	21	mediate	mediate	VBP
cord-337365-hugenn14	358	22	early	early	JJ
cord-337365-hugenn14	358	23	synapse	synapse	NN
cord-337365-hugenn14	358	24	loss	loss	NN
cord-337365-hugenn14	358	25	in	in	IN
cord-337365-hugenn14	358	26	Alzheimer	Alzheimer	NNP
cord-337365-hugenn14	358	27	mouse	mouse	NN
cord-337365-hugenn14	358	28	models	model	NNS
cord-337365-hugenn14	358	29	Mixed	mix	VBN
cord-337365-hugenn14	358	30	lineage	lineage	NN
cord-337365-hugenn14	358	31	kinase	kinase	VBZ
cord-337365-hugenn14	358	32	domain	domain	NN
cord-337365-hugenn14	358	33	-	-	HYPH
cord-337365-hugenn14	358	34	like	like	JJ
cord-337365-hugenn14	358	35	protein	protein	NN
cord-337365-hugenn14	358	36	MLKL	MLKL	NNP
cord-337365-hugenn14	358	37	causes	cause	VBZ
cord-337365-hugenn14	358	38	necrotic	necrotic	JJ
cord-337365-hugenn14	358	39	membrane	membrane	NN
cord-337365-hugenn14	358	40	disruption	disruption	NN
cord-337365-hugenn14	358	41	upon	upon	IN
cord-337365-hugenn14	358	42	phosphorylation	phosphorylation	NN
cord-337365-hugenn14	358	43	by	by	IN
cord-337365-hugenn14	359	1	RIP3	RIP3	NNP
cord-337365-hugenn14	359	2	RIP1	RIP1	NNP
cord-337365-hugenn14	359	3	/	/	SYM
cord-337365-hugenn14	359	4	RIP3	RIP3	NNS
cord-337365-hugenn14	359	5	binding	bind	VBG
cord-337365-hugenn14	359	6	to	to	IN
cord-337365-hugenn14	359	7	HSV-1	HSV-1	NNP
cord-337365-hugenn14	359	8	ICP6	ICP6	NNP
cord-337365-hugenn14	359	9	initiates	initiate	VBZ
cord-337365-hugenn14	359	10	necroptosis	necroptosis	NN
cord-337365-hugenn14	359	11	to	to	TO
cord-337365-hugenn14	359	12	restrict	restrict	VB
cord-337365-hugenn14	359	13	virus	virus	NN
cord-337365-hugenn14	359	14	propagation	propagation	NN
cord-337365-hugenn14	359	15	in	in	IN
cord-337365-hugenn14	359	16	mice	mouse	NNS
cord-337365-hugenn14	360	1	Oberst	Oberst	NNP
cord-337365-hugenn14	360	2	a.	a.	NN
cord-337365-hugenn14	360	3	RIPK3	ripk3	NN
cord-337365-hugenn14	360	4	restricts	restrict	VBZ
cord-337365-hugenn14	360	5	viral	viral	JJ
cord-337365-hugenn14	360	6	pathogenesis	pathogenesis	NN
cord-337365-hugenn14	360	7	via	via	IN
cord-337365-hugenn14	360	8	cell	cell	NN
cord-337365-hugenn14	360	9	death	death	NN
cord-337365-hugenn14	360	10	independent	independent	JJ
cord-337365-hugenn14	360	11	neuroinflammation	neuroinflammation	NN
cord-337365-hugenn14	360	12	Microglia	Microglia	NNP
cord-337365-hugenn14	360	13	:	:	:
cord-337365-hugenn14	361	1	scapegoat	scapegoat	NN
cord-337365-hugenn14	361	2	,	,	,
cord-337365-hugenn14	361	3	saboteur	saboteur	NN
cord-337365-hugenn14	361	4	,	,	,
cord-337365-hugenn14	361	5	or	or	CC
cord-337365-hugenn14	361	6	something	something	NN
cord-337365-hugenn14	361	7	else	else	RB
cord-337365-hugenn14	361	8	?	?	.
cord-337365-hugenn14	362	1	Sublime	sublime	JJ
cord-337365-hugenn14	362	2	microglia	microglia	NNS
cord-337365-hugenn14	362	3	:	:	:
cord-337365-hugenn14	363	1	expanding	expand	VBG
cord-337365-hugenn14	363	2	roles	role	NNS
cord-337365-hugenn14	363	3	for	for	IN
cord-337365-hugenn14	363	4	the	the	DT
cord-337365-hugenn14	363	5	guardians	guardian	NNS
cord-337365-hugenn14	363	6	of	of	IN
cord-337365-hugenn14	363	7	the	the	DT
cord-337365-hugenn14	363	8	CNS	CNS	NNP
cord-337365-hugenn14	363	9	Resting	rest	VBG
cord-337365-hugenn14	363	10	microglial	microglial	JJ
cord-337365-hugenn14	363	11	cells	cell	NNS
cord-337365-hugenn14	363	12	are	be	VBP
cord-337365-hugenn14	363	13	highly	highly	RB
cord-337365-hugenn14	363	14	dynamic	dynamic	JJ
cord-337365-hugenn14	363	15	surveillants	surveillant	NNS
cord-337365-hugenn14	363	16	of	of	IN
cord-337365-hugenn14	363	17	brain	brain	NN
cord-337365-hugenn14	363	18	parenchyma	parenchyma	NN
cord-337365-hugenn14	363	19	in	in	IN
cord-337365-hugenn14	363	20	vivo	vivo	NNP
cord-337365-hugenn14	363	21	Heterogeneity	heterogeneity	NN
cord-337365-hugenn14	363	22	of	of	IN
cord-337365-hugenn14	363	23	CNS	CNS	NNP
cord-337365-hugenn14	363	24	myeloid	myeloid	NN
cord-337365-hugenn14	363	25	cells	cell	NNS
cord-337365-hugenn14	363	26	and	and	CC
cord-337365-hugenn14	363	27	their	-PRON-	PRP$
cord-337365-hugenn14	363	28	roles	role	NNS
cord-337365-hugenn14	363	29	in	in	IN
cord-337365-hugenn14	363	30	neurodegeneration	neurodegeneration	NN
cord-337365-hugenn14	363	31	Regulation	regulation	NN
cord-337365-hugenn14	363	32	of	of	IN
cord-337365-hugenn14	363	33	microglia	microglia	NNP
cord-337365-hugenn14	363	34	development	development	NN
cord-337365-hugenn14	363	35	and	and	CC
cord-337365-hugenn14	363	36	homeostasis	homeostasis	NN
cord-337365-hugenn14	363	37	Development	development	NN
cord-337365-hugenn14	363	38	and	and	CC
cord-337365-hugenn14	363	39	homeostasis	homeostasis	NN
cord-337365-hugenn14	363	40	of	of	IN
cord-337365-hugenn14	363	41	"	"	``
cord-337365-hugenn14	363	42	resident	resident	JJ
cord-337365-hugenn14	363	43	"	"	''
cord-337365-hugenn14	363	44	myeloid	myeloid	NN
cord-337365-hugenn14	363	45	cells	cell	NNS
cord-337365-hugenn14	363	46	:	:	:
cord-337365-hugenn14	363	47	the	the	DT
cord-337365-hugenn14	363	48	case	case	NN
cord-337365-hugenn14	363	49	of	of	IN
cord-337365-hugenn14	363	50	the	the	DT
cord-337365-hugenn14	363	51	microglia	microglia	JJ
cord-337365-hugenn14	363	52	Clearance	Clearance	NNP
cord-337365-hugenn14	363	53	of	of	IN
cord-337365-hugenn14	363	54	apoptotic	apoptotic	JJ
cord-337365-hugenn14	363	55	neurons	neuron	NNS
cord-337365-hugenn14	363	56	without	without	IN
cord-337365-hugenn14	363	57	inflammation	inflammation	NN
cord-337365-hugenn14	363	58	by	by	IN
cord-337365-hugenn14	363	59	microglial	microglial	JJ
cord-337365-hugenn14	363	60	triggering	trigger	VBG
cord-337365-hugenn14	363	61	receptor	receptor	NN
cord-337365-hugenn14	363	62	expressed	express	VBN
cord-337365-hugenn14	363	63	on	on	IN
cord-337365-hugenn14	363	64	myeloid	myeloid	NN
cord-337365-hugenn14	363	65	cells-2	cells-2	IN
cord-337365-hugenn14	363	66	Gsecretase	Gsecretase	NNP
cord-337365-hugenn14	363	67	component	component	NN
cord-337365-hugenn14	363	68	presenilin	presenilin	NN
cord-337365-hugenn14	363	69	is	be	VBZ
cord-337365-hugenn14	363	70	important	important	JJ
cord-337365-hugenn14	363	71	for	for	IN
cord-337365-hugenn14	363	72	microglia	microglia	NNP
cord-337365-hugenn14	363	73	b	b	NN
cord-337365-hugenn14	363	74	-	-	HYPH
cord-337365-hugenn14	363	75	amyloid	amyloid	NN
cord-337365-hugenn14	363	76	clearance	clearance	NN
cord-337365-hugenn14	363	77	Myeloid	Myeloid	NNP
cord-337365-hugenn14	363	78	cells	cell	NNS
cord-337365-hugenn14	363	79	in	in	IN
cord-337365-hugenn14	363	80	the	the	DT
cord-337365-hugenn14	363	81	central	central	JJ
cord-337365-hugenn14	363	82	nervous	nervous	JJ
cord-337365-hugenn14	363	83	system	system	NN
cord-337365-hugenn14	364	1	Differential	differential	JJ
cord-337365-hugenn14	364	2	roles	role	NNS
cord-337365-hugenn14	364	3	of	of	IN
cord-337365-hugenn14	364	4	microglia	microglia	NNS
cord-337365-hugenn14	364	5	and	and	CC
cord-337365-hugenn14	364	6	monocytes	monocyte	NNS
cord-337365-hugenn14	364	7	in	in	IN
cord-337365-hugenn14	364	8	the	the	DT
cord-337365-hugenn14	364	9	inflamed	inflamed	JJ
cord-337365-hugenn14	364	10	central	central	JJ
cord-337365-hugenn14	364	11	nervous	nervous	JJ
cord-337365-hugenn14	364	12	system	system	NN
cord-337365-hugenn14	364	13	Not	not	RB
cord-337365-hugenn14	364	14	applicable	applicable	JJ
cord-337365-hugenn14	364	15	.	.	.
cord-337365-hugenn14	365	1	Not	not	RB
cord-337365-hugenn14	365	2	applicable	applicable	JJ
cord-337365-hugenn14	365	3	.	.	.
cord-337365-hugenn14	366	1	Authors	author	NNS
cord-337365-hugenn14	366	2	confirm	confirm	VBP
cord-337365-hugenn14	366	3	that	that	IN
cord-337365-hugenn14	366	4	all	all	DT
cord-337365-hugenn14	366	5	relevant	relevant	JJ
cord-337365-hugenn14	366	6	data	datum	NNS
cord-337365-hugenn14	366	7	are	be	VBP
cord-337365-hugenn14	366	8	included	include	VBN
cord-337365-hugenn14	366	9	in	in	IN
cord-337365-hugenn14	366	10	the	the	DT
cord-337365-hugenn14	366	11	article	article	NN
cord-337365-hugenn14	366	12	.	.	.
cord-337365-hugenn14	367	1	Authors	author	NNS
cord-337365-hugenn14	367	2	'	'	POS
cord-337365-hugenn14	367	3	contributions	contribution	NNS
cord-337365-hugenn14	367	4	ZC	ZC	NNP
cord-337365-hugenn14	367	5	carried	carry	VBD
cord-337365-hugenn14	367	6	out	out	RP
cord-337365-hugenn14	367	7	the	the	DT
cord-337365-hugenn14	367	8	literature	literature	NN
cord-337365-hugenn14	367	9	review	review	NN
cord-337365-hugenn14	367	10	,	,	,
cord-337365-hugenn14	367	11	participated	participate	VBD
cord-337365-hugenn14	367	12	in	in	IN
cord-337365-hugenn14	367	13	the	the	DT
cord-337365-hugenn14	367	14	sequence	sequence	NN
cord-337365-hugenn14	367	15	alignment	alignment	NN
cord-337365-hugenn14	367	16	,	,	,
cord-337365-hugenn14	367	17	and	and	CC
cord-337365-hugenn14	367	18	drafted	draft	VBD
cord-337365-hugenn14	367	19	the	the	DT
cord-337365-hugenn14	367	20	manuscript	manuscript	NN
cord-337365-hugenn14	367	21	.	.	.
cord-337365-hugenn14	368	1	DZ	DZ	NNP
cord-337365-hugenn14	368	2	helped	help	VBD
cord-337365-hugenn14	368	3	to	to	TO
cord-337365-hugenn14	368	4	draft	draft	VB
cord-337365-hugenn14	368	5	the	the	DT
cord-337365-hugenn14	368	6	manuscript	manuscript	NN
cord-337365-hugenn14	368	7	.	.	.
cord-337365-hugenn14	369	1	GL	GL	NNP
cord-337365-hugenn14	369	2	conceived	conceive	VBD
cord-337365-hugenn14	369	3	,	,	,
cord-337365-hugenn14	369	4	designed	design	VBN
cord-337365-hugenn14	369	5	,	,	,
cord-337365-hugenn14	369	6	and	and	CC
cord-337365-hugenn14	369	7	coordinated	coordinate	VBD
cord-337365-hugenn14	369	8	the	the	DT
cord-337365-hugenn14	369	9	study	study	NN
cord-337365-hugenn14	369	10	and	and	CC
cord-337365-hugenn14	369	11	contributed	contribute	VBD
cord-337365-hugenn14	369	12	to	to	IN
cord-337365-hugenn14	369	13	and	and	CC
cord-337365-hugenn14	369	14	finalized	finalize	VBD
cord-337365-hugenn14	369	15	the	the	DT
cord-337365-hugenn14	369	16	draft	draft	NN
cord-337365-hugenn14	369	17	.	.	.
cord-337365-hugenn14	370	1	All	all	DT
cord-337365-hugenn14	370	2	authors	author	NNS
cord-337365-hugenn14	370	3	read	read	VBP
cord-337365-hugenn14	370	4	and	and	CC
cord-337365-hugenn14	370	5	approved	approve	VBD
cord-337365-hugenn14	370	6	the	the	DT
cord-337365-hugenn14	370	7	final	final	JJ
cord-337365-hugenn14	370	8	manuscript	manuscript	NN
cord-337365-hugenn14	370	9	.	.	.
cord-337365-hugenn14	371	1	Ethics	ethic	NNS
cord-337365-hugenn14	371	2	approval	approval	NN
cord-337365-hugenn14	371	3	and	and	CC
cord-337365-hugenn14	371	4	consent	consent	NN
cord-337365-hugenn14	371	5	to	to	TO
cord-337365-hugenn14	371	6	participate	participate	VB
cord-337365-hugenn14	371	7	Not	not	RB
cord-337365-hugenn14	371	8	applicable	applicable	JJ
cord-337365-hugenn14	371	9	.	.	.
cord-337365-hugenn14	372	1	Not	not	RB
cord-337365-hugenn14	372	2	applicable	applicable	JJ
cord-337365-hugenn14	372	3	as	as	IN
cord-337365-hugenn14	372	4	no	no	DT
cord-337365-hugenn14	372	5	patients	patient	NNS
cord-337365-hugenn14	372	6	/	/	SYM
cord-337365-hugenn14	372	7	participants	participant	NNS
cord-337365-hugenn14	372	8	involved	involve	VBN
cord-337365-hugenn14	372	9	in	in	IN
cord-337365-hugenn14	372	10	this	this	DT
cord-337365-hugenn14	372	11	review	review	NN
cord-337365-hugenn14	372	12	.	.	.
cord-337365-hugenn14	373	1	The	the	DT
cord-337365-hugenn14	373	2	authors	author	NNS
cord-337365-hugenn14	373	3	declare	declare	VBP
cord-337365-hugenn14	373	4	that	that	IN
cord-337365-hugenn14	373	5	they	-PRON-	PRP
cord-337365-hugenn14	373	6	have	have	VBP
cord-337365-hugenn14	373	7	no	no	DT
cord-337365-hugenn14	373	8	competing	compete	VBG
cord-337365-hugenn14	373	9	interests	interest	NNS
cord-337365-hugenn14	373	10	.	.	.
cord-337365-hugenn14	374	1	Springer	Springer	NNP
cord-337365-hugenn14	374	2	Nature	Nature	NNP
cord-337365-hugenn14	374	3	remains	remain	VBZ
cord-337365-hugenn14	374	4	neutral	neutral	JJ
cord-337365-hugenn14	374	5	with	with	IN
cord-337365-hugenn14	374	6	regard	regard	NN
cord-337365-hugenn14	374	7	to	to	IN
cord-337365-hugenn14	374	8	jurisdictional	jurisdictional	JJ
cord-337365-hugenn14	374	9	claims	claim	NNS
cord-337365-hugenn14	374	10	in	in	IN
cord-337365-hugenn14	374	11	published	publish	VBN
cord-337365-hugenn14	374	12	maps	map	NNS
cord-337365-hugenn14	374	13	and	and	CC
cord-337365-hugenn14	374	14	institutional	institutional	JJ
cord-337365-hugenn14	374	15	affiliations	affiliation	NNS
cord-337365-hugenn14	374	16	.	.	.
cord-337365-hugenn14	374	17	 	 	_SP