id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000760-4yfohp9w	Babapoor, Sankhiros	A Novel Vaccine Using Nanoparticle Platform to Present Immunogenic M2e against Avian Influenza Infection	2012-01-12		.txt	text/plain	6081	327	51	Using peptide nanoparticle technology, we have designed two novel vaccine constructs representing M2e in monomeric (Mono-M2e) and tetrameric (Tetra-M2e) forms. A multiple antigenic peptide construct containing M2e (M2e-MAP) induced strong M2especific antibody titers in the serum of mice and resulted in significant protection against influenza virus challenge [13] . Chickens after each inoculation developed high levels of antibody against the injected construct and anamnestic response clearly was seen when the plates were coated with Mono-M2e and Tetra-M2e nanoparticles and M2e-GCN4 (tetrameric M2e), respectively (Table 1, Figures 7 and 8) . In the present study, protection efficiency of two different nanoparticle constructs harboring M2e was studied as possible vaccine candidates for low-pathogenicity avian influenza infection. Vaccination of chickens with recombinant Salmonella expressing M2e and CD154 epitopes increases protection and decreases viral shedding after low pathogenic avian influenza challenge	./cache/cord-000760-4yfohp9w.txt	./txt/cord-000760-4yfohp9w.txt