id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003122-a3f4l6iu	Dou, Dan	Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement	2018-07-20		.txt	text/plain	10272	565	43	The segmentation of the influenza genome makes these additional trafficking requirements especially challenging, as each viral RNA (vRNA) gene segment must navigate the network of cellular membrane barriers during the processes of entry and assembly. To accomplish this goal, influenza A viruses (IAVs) utilize a combination of viral and cellular mechanisms to coordinate the transport of their proteins and the eight vRNA gene segments in and out of the cell. Influenza A viruses (IAVs) and type B viruses (IBVs) contain 8, negative-sense, single-stranded viral RNA (vRNA) gene segments ( Figure 1A ) (3, 4) , which encode transcripts for 10 essential viral proteins, as well as several strain-dependent accessory proteins ( Figure 1B) . In contrast to the early steps in IAV entry, vRNP trafficking to the nucleus following the fusion event is highly dependent on the host cell machinery and transport pathways [reviewed in Ref.	./cache/cord-003122-a3f4l6iu.txt	./txt/cord-003122-a3f4l6iu.txt