id author title date pages extension mime words sentences flesch summary cache txt cord-103560-28o0bauv Yechezkel, M. Optimizing antiviral treatment for seasonal influenza in the United States: A Mathematical Modeling Analysis 2020-07-30 .txt text/plain 7963 533 50 We developed an influenza transmission model that incorporates data on infectious viral load, social contact, and healthcare-seeking behavior, to evaluate the population-level impact of increasing antiviral treatment timeliness and coverage among high-risk patients in the US. We found that increasing the rate of early treatment among high-risk patients who received treatment more than 48 hours after symptoms onset, would substantially avert infections and influenza-induced hospitalizations. To evaluate the population-level impact of increased antiviral treatment coverage and timeliness of influenza-infected high-risk individuals during influenza seasons, we developed a data-driven influenza transmission model that incorporates data on infectious viral load, social contact, healthcare-seeking behavior, time to seek healthcare, and antiviral treatment. Nevertheless, for a 20% increase in influenza effective vaccination coverage among all age groups, our results suggest that the benefit of treatment remains substantial ( All rights reserved. ./cache/cord-103560-28o0bauv.txt ./txt/cord-103560-28o0bauv.txt