id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266100-1rktb6yq	Darwish, Ilyse	Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza	2012-01-13		.txt	text/plain	2929	155	49	Therefore, we hypothesized that inhaled nitric oxide (iNO) would increase survival in vivo by reducing the viral load in C57Bl/6 mice infected with a lethal dose of influenza A/WSN/33 (H1N1; WSN/33) virus. Therefore, both continuous and intermittent iNO administration failed to reduce lung viral load of infected mice, compared to infected control mice administered compressed room air. iNO administered to influenza infected mice in this manner, either prophylactically or therapeutically, failed to improve survival of infected mice, change the course of weight loss, or decrease the lung viral load, compared to control mice receiving compressed air. In conclusion, despite the demonstrated antimicrobial activity of NO against influenza A virus in vitro, the results of this study do not support the use of iNO as a prophylactic or treatment strategy to reduce viral burden or improve clinical outcome in severe influenza in vivo.	./cache/cord-266100-1rktb6yq.txt	./txt/cord-266100-1rktb6yq.txt