id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296998-ep46lzeo	Pawelec, Graham	Recent advances in influenza vaccines	2020-04-28		.txt	text/plain	3690	170	42	Seasonal influenza remains a major public health problem, responsible for hundreds of thousands of deaths every year, mostly of elderly people. These include viral variability and hence the requirement to match strains by estimating which will become prevalent each season, problems associated with vaccine and adjuvant production, and the route of administration as well as the perceived lower vaccine efficiency in older adults. Efforts to improve the effectiveness of influenza vaccines include developing universal vaccines independent of the circulating strains in any particular season and stimulating cellular as well as humoral responses, especially in the elderly. In this way, intranasally administered vaccine resulted in protection against multiple strains of influenza in mice and ferrets, associated with both humoral and cellular responses 36 . Effect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis	./cache/cord-296998-ep46lzeo.txt	./txt/cord-296998-ep46lzeo.txt