id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325197-j1uo8qmf	Crimi, Ettore	Epigenetic susceptibility to severe respiratory viral infections: pathogenic and therapeutic implications: a narrative review	2020-08-20		.txt	text/plain	6066	342	34	Viruses causing severe pulmonary illness can use epigenetic-regulated mechanisms during host–pathogen interaction to interfere with innate and adaptive immunity, adequacy of inflammatory response, and overall outcome of viral infections. In this article, we provide an update on epigenetic-sensitive mechanisms and repurposed drugs interfering with epigenetic pathways which may be clinically suitable for risk stratification and beneficial for treatment of patients affected by severe viral respiratory infections. The goal of the review was to provide an appropriate pathogenic scenario in which epigenetic-sensitive mechanisms and epidrugs may be clinically useful to stratify risk and treatment of patients in ICU affected by severe viral respiratory infections. Here, we give an update on clinical evidence about the usefulness of novel and FDA-approved drugs interfering with epigenetic pathways, which were applied to ICU patients affected by highly pathogenic strains of influenza virus and CoV, with a particular interest about the novel SARS-CoV-2 (Table 4 ).	./cache/cord-325197-j1uo8qmf.txt	./txt/cord-325197-j1uo8qmf.txt