id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335647-dhcxj7cj	Vanderlinden, Evelien	Emerging Antiviral Strategies to Interfere with Influenza Virus Entry	2013-06-25		.txt	text/plain	15104	870	43	We here focus on emerging options to interfere with the influenza virus entry process, which consists of the following steps: attachment of the viral hemagglutinin to the sialylated host cell receptors, endocytosis, M2‐mediated uncoating, low pH‐induced membrane fusion, and, finally, import of the viral ribonucleoprotein into the nucleus. There are three conceivable strategies for inhibiting attachment of influenza virus to its target cell: (i) an antiviral compound binding to the HA RBS; (ii) an inhibitor blocking the sialic acid-containing receptors on the epithelial cell membrane; or (iii) a receptor-destroying agent. 91 Regarding potential antiviral use, design of modified forms of the porcine SP-D lectin (which has higher anti-influenza virus activity than its human counterpart) is aided by the growing insight into how its carbohydrate recognition domain (CRD) precisely interacts with the high-mannose glycans attached near the RBS of HA.	./cache/cord-335647-dhcxj7cj.txt	./txt/cord-335647-dhcxj7cj.txt