id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336493-ggo9wsrm	Huang, Stephen S. H.	Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure	2013-04-23		.txt	text/plain	6444	342	46	In our present study, we investigated the clinical characteristics and immune cross-reactivity of significant H1N1 influenza strains in the past 100 years in ferrets to determine the immunogenicity of important H1N1 viruses. Ferrets show respiratory illness similar to humans and clinical features of disease are easily observed where fevers can persist days following infection of viruses such as 2009 H1N1pdm influenza 21, 23, 30 . As well as fever, nasal discharge and sneezing can also be observed in animals infected with influenza viruses 21 These influenza A viruses were chosen due to their emergence and influence in H1N1 genetic history (Fig. 1 , strains used in this study are marked with an asterisks) as covered in the introduction. The immunogenic findings showed antisera produced from ferret infection with Taiwan/86 was not able to inhibit hemagglutination with the other viruses on our virus panel, which compliments the literature describing the 1986 strain.	./cache/cord-336493-ggo9wsrm.txt	./txt/cord-336493-ggo9wsrm.txt