id author title date pages extension mime words sentences flesch summary cache txt cord-340678-2e2s1gof Skowronski, Danuta M Influenza vaccine does not increase the risk of coronavirus or other non-influenza respiratory viruses: retrospective analysis from Canada, 2010-11 to 2016-17 2020-05-22 .txt text/plain 1646 113 45 Influenza vaccine effectiveness against influenza and non-influenza respiratory viruses (NIRV) was assessed by test-negative design using historic datasets of the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN), spanning 2010-11 to 2016-17. Here, we use historic datasets of the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) to assess the association between influenza vaccine and NIRV risk, notably seasonal coronaviruses. Conversely, influenza vaccine had no effect on non-influenza causes of ILI, with the likelihood of vaccination among NIRV cases relative to test-negative controls approaching unity. In combined NIRV analysis, relative to pan-negative controls, Wolff adjusted for age and excluded specimens that tested influenza-positive. We illustrate the impact of this bias in Supplementary_Material_3, where we have re-analyzed Wolff's data as well as our own, comparing influenza vaccine effect against NIRV when influenza testpositive specimens are properly excluded (as per TND prerequisite) or improperly included (as per Wolff [4] ) within the control group. ./cache/cord-340678-2e2s1gof.txt ./txt/cord-340678-2e2s1gof.txt