id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355374-e8k72955	Clemens, E. Bridie	Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine	2018-03-26		.txt	text/plain	14155	614	38	Influenza virus-specific CD8 + Trm in human lung tissue also maintain diverse TCR profiles-a feature important for effective T cell function and protection against the generation of viral-escape mutants [128] . HLA-I allele expression is an important predictor of cross-reactive influenza-specific CD8 + T cell immunity, with a recent study identifying five alleles (A*02:01, A*03:01, B*57:01, B*18:01, and B*08:01) capable of eliciting robust CD8 + T cell responses against immunogenic NP and M1 peptides that are conserved across all human influenza A virus, including the novel avian-derived H7N9 virus [18] . Thus, upon infection with H7N9, individuals with these HLA alleles will need time to activate and amplify new primary CD8 + T cell responses to distinct H7N9 peptide variants rather than recalling T cell responses generated against seasonal influenza viruses, potentially resulting in longer time to recovery and greater risk of severe disease compared to individuals with pre-existing cross-protective CD8 + T cell memory.	./cache/cord-355374-e8k72955.txt	./txt/cord-355374-e8k72955.txt