id	sid	tid	token	lemma	pos
cord-002407-25cawzi0	1	1	key	key	JJ
cord-002407-25cawzi0	2	1	:	:	:
cord-002407-25cawzi0	2	2	cord-002407	cord-002407	JJ
cord-002407-25cawzi0	2	3	-	-	HYPH
cord-002407-25cawzi0	2	4	25cawzi0	25cawzi0	CD
cord-002407-25cawzi0	2	5	authors	author	NNS
cord-002407-25cawzi0	2	6	:	:	:
cord-002407-25cawzi0	2	7	Nogales	Nogales	NNP
cord-002407-25cawzi0	2	8	,	,	,
cord-002407-25cawzi0	2	9	Aitor	Aitor	NNP
cord-002407-25cawzi0	2	10	;	;	:
cord-002407-25cawzi0	2	11	Martínez	Martínez	NNP
cord-002407-25cawzi0	2	12	-	-	HYPH
cord-002407-25cawzi0	2	13	Sobrido	Sobrido	NNP
cord-002407-25cawzi0	2	14	,	,	,
cord-002407-25cawzi0	2	15	Luis	Luis	NNP
cord-002407-25cawzi0	2	16	title	title	NN
cord-002407-25cawzi0	2	17	:	:	:
cord-002407-25cawzi0	3	1	Reverse	Reverse	NNP
cord-002407-25cawzi0	3	2	Genetics	Genetics	NNP
cord-002407-25cawzi0	3	3	Approaches	Approaches	NNPS
cord-002407-25cawzi0	3	4	for	for	IN
cord-002407-25cawzi0	3	5	the	the	DT
cord-002407-25cawzi0	3	6	Development	Development	NNP
cord-002407-25cawzi0	3	7	of	of	IN
cord-002407-25cawzi0	3	8	Influenza	Influenza	NNP
cord-002407-25cawzi0	3	9	Vaccines	Vaccines	NNPS
cord-002407-25cawzi0	3	10	date	date	NN
cord-002407-25cawzi0	3	11	:	:	:
cord-002407-25cawzi0	3	12	2016	2016	CD
cord-002407-25cawzi0	3	13	-	-	HYPH
cord-002407-25cawzi0	3	14	12	12	CD
cord-002407-25cawzi0	3	15	-	-	SYM
cord-002407-25cawzi0	3	16	22	22	CD
cord-002407-25cawzi0	3	17	journal	journal	NN
cord-002407-25cawzi0	3	18	:	:	:
cord-002407-25cawzi0	4	1	Int	Int	NNP
cord-002407-25cawzi0	4	2	J	J	NNP
cord-002407-25cawzi0	4	3	Mol	Mol	NNP
cord-002407-25cawzi0	4	4	Sci	Sci	NNP
cord-002407-25cawzi0	4	5	DOI	DOI	NNP
cord-002407-25cawzi0	4	6	:	:	:
cord-002407-25cawzi0	4	7	10.3390	10.3390	CD
cord-002407-25cawzi0	4	8	/	/	SYM
cord-002407-25cawzi0	4	9	ijms18010020	ijms18010020	NNP
cord-002407-25cawzi0	4	10	sha	sha	NNP
cord-002407-25cawzi0	4	11	:	:	:
cord-002407-25cawzi0	4	12	4b3de92b03457bddd57edad106262751d712c528	4b3de92b03457bddd57edad106262751d712c528	CD
cord-002407-25cawzi0	4	13	doc_id	doc_id	CD
cord-002407-25cawzi0	4	14	:	:	:
cord-002407-25cawzi0	4	15	2407	2407	CD
cord-002407-25cawzi0	5	1	cord_uid	cord_uid	NN
cord-002407-25cawzi0	5	2	:	:	:
cord-002407-25cawzi0	6	1	25cawzi0	25cawzi0	CD
cord-002407-25cawzi0	7	1	Influenza	influenza	NN
cord-002407-25cawzi0	7	2	viruses	virus	NNS
cord-002407-25cawzi0	7	3	cause	cause	VBP
cord-002407-25cawzi0	7	4	annual	annual	JJ
cord-002407-25cawzi0	7	5	seasonal	seasonal	JJ
cord-002407-25cawzi0	7	6	epidemics	epidemic	NNS
cord-002407-25cawzi0	7	7	and	and	CC
cord-002407-25cawzi0	7	8	occasional	occasional	JJ
cord-002407-25cawzi0	7	9	pandemics	pandemic	NNS
cord-002407-25cawzi0	7	10	of	of	IN
cord-002407-25cawzi0	7	11	human	human	JJ
cord-002407-25cawzi0	7	12	respiratory	respiratory	JJ
cord-002407-25cawzi0	7	13	disease	disease	NN
cord-002407-25cawzi0	7	14	.	.	.
cord-002407-25cawzi0	8	1	Influenza	influenza	NN
cord-002407-25cawzi0	8	2	virus	virus	NN
cord-002407-25cawzi0	8	3	infections	infection	NNS
cord-002407-25cawzi0	8	4	represent	represent	VBP
cord-002407-25cawzi0	8	5	a	a	DT
cord-002407-25cawzi0	8	6	serious	serious	JJ
cord-002407-25cawzi0	8	7	public	public	JJ
cord-002407-25cawzi0	8	8	health	health	NN
cord-002407-25cawzi0	8	9	and	and	CC
cord-002407-25cawzi0	8	10	economic	economic	JJ
cord-002407-25cawzi0	8	11	problem	problem	NN
cord-002407-25cawzi0	8	12	,	,	,
cord-002407-25cawzi0	8	13	which	which	WDT
cord-002407-25cawzi0	8	14	are	be	VBP
cord-002407-25cawzi0	8	15	most	most	RBS
cord-002407-25cawzi0	8	16	effectively	effectively	RB
cord-002407-25cawzi0	8	17	prevented	prevent	VBN
cord-002407-25cawzi0	8	18	through	through	IN
cord-002407-25cawzi0	8	19	vaccination	vaccination	NN
cord-002407-25cawzi0	8	20	.	.	.
cord-002407-25cawzi0	9	1	However	however	RB
cord-002407-25cawzi0	9	2	,	,	,
cord-002407-25cawzi0	9	3	influenza	influenza	NN
cord-002407-25cawzi0	9	4	viruses	virus	NNS
cord-002407-25cawzi0	9	5	undergo	undergo	VBP
cord-002407-25cawzi0	9	6	continual	continual	JJ
cord-002407-25cawzi0	9	7	antigenic	antigenic	JJ
cord-002407-25cawzi0	9	8	variation	variation	NN
cord-002407-25cawzi0	9	9	,	,	,
cord-002407-25cawzi0	9	10	which	which	WDT
cord-002407-25cawzi0	9	11	requires	require	VBZ
cord-002407-25cawzi0	9	12	either	either	CC
cord-002407-25cawzi0	9	13	the	the	DT
cord-002407-25cawzi0	9	14	annual	annual	JJ
cord-002407-25cawzi0	9	15	reformulation	reformulation	NN
cord-002407-25cawzi0	9	16	of	of	IN
cord-002407-25cawzi0	9	17	seasonal	seasonal	JJ
cord-002407-25cawzi0	9	18	influenza	influenza	NN
cord-002407-25cawzi0	9	19	vaccines	vaccine	NNS
cord-002407-25cawzi0	9	20	or	or	CC
cord-002407-25cawzi0	9	21	the	the	DT
cord-002407-25cawzi0	9	22	rapid	rapid	JJ
cord-002407-25cawzi0	9	23	generation	generation	NN
cord-002407-25cawzi0	9	24	of	of	IN
cord-002407-25cawzi0	9	25	vaccines	vaccine	NNS
cord-002407-25cawzi0	9	26	against	against	IN
cord-002407-25cawzi0	9	27	potential	potential	JJ
cord-002407-25cawzi0	9	28	pandemic	pandemic	NN
cord-002407-25cawzi0	9	29	virus	virus	NN
cord-002407-25cawzi0	9	30	strains	strain	NNS
cord-002407-25cawzi0	9	31	.	.	.
cord-002407-25cawzi0	10	1	The	the	DT
cord-002407-25cawzi0	10	2	segmented	segmented	JJ
cord-002407-25cawzi0	10	3	nature	nature	NN
cord-002407-25cawzi0	10	4	of	of	IN
cord-002407-25cawzi0	10	5	influenza	influenza	NN
cord-002407-25cawzi0	10	6	virus	virus	NN
cord-002407-25cawzi0	10	7	allows	allow	VBZ
cord-002407-25cawzi0	10	8	for	for	IN
cord-002407-25cawzi0	10	9	the	the	DT
cord-002407-25cawzi0	10	10	reassortment	reassortment	NN
cord-002407-25cawzi0	10	11	between	between	IN
cord-002407-25cawzi0	10	12	two	two	CD
cord-002407-25cawzi0	10	13	or	or	CC
cord-002407-25cawzi0	10	14	more	more	JJR
cord-002407-25cawzi0	10	15	viruses	virus	NNS
cord-002407-25cawzi0	10	16	within	within	IN
cord-002407-25cawzi0	10	17	a	a	DT
cord-002407-25cawzi0	10	18	co	co	JJ
cord-002407-25cawzi0	10	19	-	-	JJ
cord-002407-25cawzi0	10	20	infected	infected	JJ
cord-002407-25cawzi0	10	21	cell	cell	NN
cord-002407-25cawzi0	10	22	,	,	,
cord-002407-25cawzi0	10	23	and	and	CC
cord-002407-25cawzi0	10	24	this	this	DT
cord-002407-25cawzi0	10	25	characteristic	characteristic	NN
cord-002407-25cawzi0	10	26	has	have	VBZ
cord-002407-25cawzi0	10	27	also	also	RB
cord-002407-25cawzi0	10	28	been	be	VBN
cord-002407-25cawzi0	10	29	harnessed	harness	VBN
cord-002407-25cawzi0	10	30	in	in	IN
cord-002407-25cawzi0	10	31	the	the	DT
cord-002407-25cawzi0	10	32	laboratory	laboratory	NN
cord-002407-25cawzi0	10	33	to	to	TO
cord-002407-25cawzi0	10	34	generate	generate	VB
cord-002407-25cawzi0	10	35	reassortant	reassortant	JJ
cord-002407-25cawzi0	10	36	viruses	virus	NNS
cord-002407-25cawzi0	10	37	for	for	IN
cord-002407-25cawzi0	10	38	their	-PRON-	PRP$
cord-002407-25cawzi0	10	39	use	use	NN
cord-002407-25cawzi0	10	40	as	as	IN
cord-002407-25cawzi0	10	41	either	either	CC
cord-002407-25cawzi0	10	42	inactivated	inactivate	VBN
cord-002407-25cawzi0	10	43	or	or	CC
cord-002407-25cawzi0	10	44	live	live	RB
cord-002407-25cawzi0	10	45	-	-	HYPH
cord-002407-25cawzi0	10	46	attenuated	attenuate	VBN
cord-002407-25cawzi0	10	47	influenza	influenza	NN
cord-002407-25cawzi0	10	48	vaccines	vaccine	NNS
cord-002407-25cawzi0	10	49	.	.	.
cord-002407-25cawzi0	11	1	With	with	IN
cord-002407-25cawzi0	11	2	the	the	DT
cord-002407-25cawzi0	11	3	implementation	implementation	NN
cord-002407-25cawzi0	11	4	of	of	IN
cord-002407-25cawzi0	11	5	plasmid	plasmid	NN
cord-002407-25cawzi0	11	6	-	-	HYPH
cord-002407-25cawzi0	11	7	based	base	VBN
cord-002407-25cawzi0	11	8	reverse	reverse	JJ
cord-002407-25cawzi0	11	9	genetics	genetics	NN
cord-002407-25cawzi0	11	10	techniques	technique	NNS
cord-002407-25cawzi0	11	11	,	,	,
cord-002407-25cawzi0	11	12	it	-PRON-	PRP
cord-002407-25cawzi0	11	13	is	be	VBZ
cord-002407-25cawzi0	11	14	now	now	RB
cord-002407-25cawzi0	11	15	possible	possible	JJ
cord-002407-25cawzi0	11	16	to	to	TO
cord-002407-25cawzi0	11	17	engineer	engineer	VB
cord-002407-25cawzi0	11	18	recombinant	recombinant	JJ
cord-002407-25cawzi0	11	19	influenza	influenza	NN
cord-002407-25cawzi0	11	20	viruses	virus	NNS
cord-002407-25cawzi0	11	21	entirely	entirely	RB
cord-002407-25cawzi0	11	22	from	from	IN
cord-002407-25cawzi0	11	23	full	full	JJ
cord-002407-25cawzi0	11	24	-	-	HYPH
cord-002407-25cawzi0	11	25	length	length	NN
cord-002407-25cawzi0	11	26	complementary	complementary	JJ
cord-002407-25cawzi0	11	27	DNA	dna	NN
cord-002407-25cawzi0	11	28	copies	copy	NNS
cord-002407-25cawzi0	11	29	of	of	IN
cord-002407-25cawzi0	11	30	the	the	DT
cord-002407-25cawzi0	11	31	viral	viral	JJ
cord-002407-25cawzi0	11	32	genome	genome	NN
cord-002407-25cawzi0	11	33	by	by	IN
cord-002407-25cawzi0	11	34	transfection	transfection	NN
cord-002407-25cawzi0	11	35	of	of	IN
cord-002407-25cawzi0	11	36	susceptible	susceptible	JJ
cord-002407-25cawzi0	11	37	cells	cell	NNS
cord-002407-25cawzi0	11	38	.	.	.
cord-002407-25cawzi0	12	1	These	these	DT
cord-002407-25cawzi0	12	2	reverse	reverse	JJ
cord-002407-25cawzi0	12	3	genetics	genetics	NN
cord-002407-25cawzi0	12	4	systems	system	NNS
cord-002407-25cawzi0	12	5	have	have	VBP
cord-002407-25cawzi0	12	6	provided	provide	VBN
cord-002407-25cawzi0	12	7	investigators	investigator	NNS
cord-002407-25cawzi0	12	8	with	with	IN
cord-002407-25cawzi0	12	9	novel	novel	JJ
cord-002407-25cawzi0	12	10	and	and	CC
cord-002407-25cawzi0	12	11	powerful	powerful	JJ
cord-002407-25cawzi0	12	12	approaches	approach	NNS
cord-002407-25cawzi0	12	13	to	to	TO
cord-002407-25cawzi0	12	14	answer	answer	VB
cord-002407-25cawzi0	12	15	important	important	JJ
cord-002407-25cawzi0	12	16	questions	question	NNS
cord-002407-25cawzi0	12	17	about	about	IN
cord-002407-25cawzi0	12	18	the	the	DT
cord-002407-25cawzi0	12	19	biology	biology	NN
cord-002407-25cawzi0	12	20	of	of	IN
cord-002407-25cawzi0	12	21	influenza	influenza	NN
cord-002407-25cawzi0	12	22	viruses	virus	NNS
cord-002407-25cawzi0	12	23	,	,	,
cord-002407-25cawzi0	12	24	including	include	VBG
cord-002407-25cawzi0	12	25	the	the	DT
cord-002407-25cawzi0	12	26	function	function	NN
cord-002407-25cawzi0	12	27	of	of	IN
cord-002407-25cawzi0	12	28	viral	viral	JJ
cord-002407-25cawzi0	12	29	proteins	protein	NNS
cord-002407-25cawzi0	12	30	,	,	,
cord-002407-25cawzi0	12	31	their	-PRON-	PRP$
cord-002407-25cawzi0	12	32	interaction	interaction	NN
cord-002407-25cawzi0	12	33	with	with	IN
cord-002407-25cawzi0	12	34	cellular	cellular	JJ
cord-002407-25cawzi0	12	35	host	host	NN
cord-002407-25cawzi0	12	36	factors	factor	NNS
cord-002407-25cawzi0	12	37	and	and	CC
cord-002407-25cawzi0	12	38	the	the	DT
cord-002407-25cawzi0	12	39	mechanisms	mechanism	NNS
cord-002407-25cawzi0	12	40	of	of	IN
cord-002407-25cawzi0	12	41	influenza	influenza	NN
cord-002407-25cawzi0	12	42	virus	virus	NN
cord-002407-25cawzi0	12	43	transmission	transmission	NN
cord-002407-25cawzi0	12	44	and	and	CC
cord-002407-25cawzi0	12	45	pathogenesis	pathogenesis	NN
cord-002407-25cawzi0	12	46	.	.	.
cord-002407-25cawzi0	13	1	In	in	IN
cord-002407-25cawzi0	13	2	addition	addition	NN
cord-002407-25cawzi0	13	3	,	,	,
cord-002407-25cawzi0	13	4	reverse	reverse	VB
cord-002407-25cawzi0	13	5	genetics	genetics	NN
cord-002407-25cawzi0	13	6	techniques	technique	NNS
cord-002407-25cawzi0	13	7	have	have	VBP
cord-002407-25cawzi0	13	8	allowed	allow	VBN
cord-002407-25cawzi0	13	9	the	the	DT
cord-002407-25cawzi0	13	10	generation	generation	NN
cord-002407-25cawzi0	13	11	of	of	IN
cord-002407-25cawzi0	13	12	recombinant	recombinant	JJ
cord-002407-25cawzi0	13	13	influenza	influenza	NN
cord-002407-25cawzi0	13	14	viruses	virus	NNS
cord-002407-25cawzi0	13	15	,	,	,
cord-002407-25cawzi0	13	16	providing	provide	VBG
cord-002407-25cawzi0	13	17	a	a	DT
cord-002407-25cawzi0	13	18	powerful	powerful	JJ
cord-002407-25cawzi0	13	19	technology	technology	NN
cord-002407-25cawzi0	13	20	to	to	TO
cord-002407-25cawzi0	13	21	develop	develop	VB
cord-002407-25cawzi0	13	22	both	both	DT
cord-002407-25cawzi0	13	23	inactivated	inactivate	VBN
cord-002407-25cawzi0	13	24	and	and	CC
cord-002407-25cawzi0	13	25	live	live	RB
cord-002407-25cawzi0	13	26	-	-	HYPH
cord-002407-25cawzi0	13	27	attenuated	attenuate	VBN
cord-002407-25cawzi0	13	28	influenza	influenza	NN
cord-002407-25cawzi0	13	29	vaccines	vaccine	NNS
cord-002407-25cawzi0	13	30	.	.	.
cord-002407-25cawzi0	14	1	In	in	IN
cord-002407-25cawzi0	14	2	this	this	DT
cord-002407-25cawzi0	14	3	review	review	NN
cord-002407-25cawzi0	14	4	,	,	,
cord-002407-25cawzi0	14	5	we	-PRON-	PRP
cord-002407-25cawzi0	14	6	will	will	MD
cord-002407-25cawzi0	14	7	summarize	summarize	VB
cord-002407-25cawzi0	14	8	the	the	DT
cord-002407-25cawzi0	14	9	current	current	JJ
cord-002407-25cawzi0	14	10	knowledge	knowledge	NN
cord-002407-25cawzi0	14	11	of	of	IN
cord-002407-25cawzi0	14	12	state	state	NN
cord-002407-25cawzi0	14	13	-	-	HYPH
cord-002407-25cawzi0	14	14	of	of	IN
cord-002407-25cawzi0	14	15	-	-	HYPH
cord-002407-25cawzi0	14	16	the	the	DT
cord-002407-25cawzi0	14	17	-	-	HYPH
cord-002407-25cawzi0	14	18	art	art	NN
cord-002407-25cawzi0	14	19	,	,	,
cord-002407-25cawzi0	14	20	plasmid	plasmid	NN
cord-002407-25cawzi0	14	21	-	-	HYPH
cord-002407-25cawzi0	14	22	based	base	VBN
cord-002407-25cawzi0	14	23	,	,	,
cord-002407-25cawzi0	14	24	influenza	influenza	NN
cord-002407-25cawzi0	14	25	reverse	reverse	JJ
cord-002407-25cawzi0	14	26	genetics	genetics	NN
cord-002407-25cawzi0	14	27	approaches	approach	NNS
cord-002407-25cawzi0	14	28	and	and	CC
cord-002407-25cawzi0	14	29	their	-PRON-	PRP$
cord-002407-25cawzi0	14	30	implementation	implementation	NN
cord-002407-25cawzi0	14	31	to	to	TO
cord-002407-25cawzi0	14	32	provide	provide	VB
cord-002407-25cawzi0	14	33	rapid	rapid	JJ
cord-002407-25cawzi0	14	34	,	,	,
cord-002407-25cawzi0	14	35	convenient	convenient	JJ
cord-002407-25cawzi0	14	36	,	,	,
cord-002407-25cawzi0	14	37	safe	safe	JJ
cord-002407-25cawzi0	14	38	and	and	CC
cord-002407-25cawzi0	14	39	more	more	RBR
cord-002407-25cawzi0	14	40	effective	effective	JJ
cord-002407-25cawzi0	14	41	influenza	influenza	NN
cord-002407-25cawzi0	14	42	inactivated	inactivate	VBN
cord-002407-25cawzi0	14	43	or	or	CC
cord-002407-25cawzi0	14	44	live	live	RB
cord-002407-25cawzi0	14	45	-	-	HYPH
cord-002407-25cawzi0	14	46	attenuated	attenuate	VBN
cord-002407-25cawzi0	14	47	vaccines	vaccine	NNS
cord-002407-25cawzi0	14	48	.	.	.
cord-002407-25cawzi0	15	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	15	2	A	A	NNP
cord-002407-25cawzi0	15	3	(	(	-LRB-
cord-002407-25cawzi0	15	4	IAV	IAV	NNP
cord-002407-25cawzi0	15	5	)	)	-RRB-
cord-002407-25cawzi0	15	6	and	and	CC
cord-002407-25cawzi0	15	7	B	B	NNP
cord-002407-25cawzi0	15	8	(	(	-LRB-
cord-002407-25cawzi0	15	9	IBV	IBV	NNP
cord-002407-25cawzi0	15	10	)	)	-RRB-
cord-002407-25cawzi0	15	11	viruses	virus	NNS
cord-002407-25cawzi0	15	12	belong	belong	VBP
cord-002407-25cawzi0	15	13	to	to	IN
cord-002407-25cawzi0	15	14	the	the	DT
cord-002407-25cawzi0	15	15	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-002407-25cawzi0	15	16	family	family	NN
cord-002407-25cawzi0	15	17	of	of	IN
cord-002407-25cawzi0	15	18	enveloped	envelop	VBN
cord-002407-25cawzi0	15	19	viruses	virus	NNS
cord-002407-25cawzi0	15	20	[	[	-LRB-
cord-002407-25cawzi0	15	21	1	1	CD
cord-002407-25cawzi0	15	22	]	]	-RRB-
cord-002407-25cawzi0	15	23	.	.	.
cord-002407-25cawzi0	16	1	IAV	IAV	NNP
cord-002407-25cawzi0	16	2	is	be	VBZ
cord-002407-25cawzi0	16	3	able	able	JJ
cord-002407-25cawzi0	16	4	to	to	TO
cord-002407-25cawzi0	16	5	infect	infect	VB
cord-002407-25cawzi0	16	6	several	several	JJ
cord-002407-25cawzi0	16	7	species	specie	NNS
cord-002407-25cawzi0	16	8	and	and	CC
cord-002407-25cawzi0	16	9	mostly	mostly	RB
cord-002407-25cawzi0	16	10	exists	exist	VBZ
cord-002407-25cawzi0	16	11	in	in	IN
cord-002407-25cawzi0	16	12	the	the	DT
cord-002407-25cawzi0	16	13	wild	wild	JJ
cord-002407-25cawzi0	16	14	aquatic	aquatic	JJ
cord-002407-25cawzi0	16	15	fowl	fowl	NN
cord-002407-25cawzi0	16	16	reservoir	reservoir	NN
cord-002407-25cawzi0	16	17	[	[	-LRB-
cord-002407-25cawzi0	16	18	2	2	CD
cord-002407-25cawzi0	16	19	]	]	-RRB-
cord-002407-25cawzi0	16	20	[	[	-LRB-
cord-002407-25cawzi0	16	21	3	3	CD
cord-002407-25cawzi0	16	22	]	]	-RRB-
cord-002407-25cawzi0	16	23	[	[	-LRB-
cord-002407-25cawzi0	16	24	4	4	CD
cord-002407-25cawzi0	16	25	]	]	-RRB-
cord-002407-25cawzi0	16	26	.	.	.
cord-002407-25cawzi0	17	1	On	on	IN
cord-002407-25cawzi0	17	2	the	the	DT
cord-002407-25cawzi0	17	3	other	other	JJ
cord-002407-25cawzi0	17	4	hand	hand	NN
cord-002407-25cawzi0	17	5	,	,	,
cord-002407-25cawzi0	17	6	IBV	IBV	NNP
cord-002407-25cawzi0	17	7	is	be	VBZ
cord-002407-25cawzi0	17	8	mainly	mainly	RB
cord-002407-25cawzi0	17	9	restricted	restrict	VBN
cord-002407-25cawzi0	17	10	and	and	CC
cord-002407-25cawzi0	17	11	adapted	adapt	VBN
cord-002407-25cawzi0	17	12	to	to	IN
cord-002407-25cawzi0	17	13	humans	human	NNS
cord-002407-25cawzi0	17	14	,	,	,
cord-002407-25cawzi0	17	15	although	although	IN
cord-002407-25cawzi0	17	16	sporadic	sporadic	JJ
cord-002407-25cawzi0	17	17	infections	infection	NNS
cord-002407-25cawzi0	17	18	of	of	IN
cord-002407-25cawzi0	17	19	seals	seal	NNS
cord-002407-25cawzi0	17	20	have	have	VBP
cord-002407-25cawzi0	17	21	been	be	VBN
cord-002407-25cawzi0	17	22	documented	document	VBN
cord-002407-25cawzi0	17	23	[	[	-LRB-
cord-002407-25cawzi0	17	24	5	5	CD
cord-002407-25cawzi0	17	25	,	,	,
cord-002407-25cawzi0	17	26	6	6	CD
cord-002407-25cawzi0	17	27	]	]	-RRB-
cord-002407-25cawzi0	17	28	.	.	.
cord-002407-25cawzi0	18	1	IAV	IAV	NNP
cord-002407-25cawzi0	18	2	and	and	CC
cord-002407-25cawzi0	18	3	IBV	IBV	NNP
cord-002407-25cawzi0	18	4	genomes	genome	NNS
cord-002407-25cawzi0	18	5	contain	contain	VBP
cord-002407-25cawzi0	18	6	eight	eight	CD
cord-002407-25cawzi0	18	7	negative	negative	JJ
cord-002407-25cawzi0	18	8	sense	sense	NN
cord-002407-25cawzi0	18	9	,	,	,
cord-002407-25cawzi0	18	10	single	single	RB
cord-002407-25cawzi0	18	11	-	-	HYPH
cord-002407-25cawzi0	18	12	stranded	strand	VBN
cord-002407-25cawzi0	18	13	viral	viral	JJ
cord-002407-25cawzi0	18	14	(	(	-LRB-
cord-002407-25cawzi0	18	15	v)RNA	v)RNA	VBG
cord-002407-25cawzi0	18	16	segments	segment	NNS
cord-002407-25cawzi0	18	17	[	[	-LRB-
cord-002407-25cawzi0	18	18	1	1	CD
cord-002407-25cawzi0	18	19	]	]	-RRB-
cord-002407-25cawzi0	18	20	(	(	-LRB-
cord-002407-25cawzi0	18	21	Figure	figure	NN
cord-002407-25cawzi0	18	22	1	1	CD
cord-002407-25cawzi0	18	23	)	)	-RRB-
cord-002407-25cawzi0	18	24	.	.	.
cord-002407-25cawzi0	19	1	IAV	IAV	NNP
cord-002407-25cawzi0	19	2	and	and	CC
cord-002407-25cawzi0	19	3	IBV	IBV	NNP
cord-002407-25cawzi0	19	4	vRNAs	vRNAs	NNPS
cord-002407-25cawzi0	19	5	contain	contain	VBP
cord-002407-25cawzi0	19	6	a	a	DT
cord-002407-25cawzi0	19	7	central	central	JJ
cord-002407-25cawzi0	19	8	coding	code	VBG
cord-002407-25cawzi0	19	9	region	region	NN
cord-002407-25cawzi0	19	10	that	that	WDT
cord-002407-25cawzi0	19	11	is	be	VBZ
cord-002407-25cawzi0	19	12	flanked	flank	VBN
cord-002407-25cawzi0	19	13	at	at	IN
cord-002407-25cawzi0	19	14	both	both	DT
cord-002407-25cawzi0	19	15	terminal	terminal	JJ
cord-002407-25cawzi0	19	16	ends	end	NNS
cord-002407-25cawzi0	19	17	by	by	IN
cord-002407-25cawzi0	19	18	non	non	JJ
cord-002407-25cawzi0	19	19	-	-	JJ
cord-002407-25cawzi0	19	20	coding	coding	JJ
cord-002407-25cawzi0	19	21	regions	region	NNS
cord-002407-25cawzi0	19	22	(	(	-LRB-
cord-002407-25cawzi0	19	23	NCRs	NCRs	NNP
cord-002407-25cawzi0	19	24	)	)	-RRB-
cord-002407-25cawzi0	19	25	,	,	,
cord-002407-25cawzi0	19	26	which	which	WDT
cord-002407-25cawzi0	19	27	serve	serve	VBP
cord-002407-25cawzi0	19	28	as	as	IN
cord-002407-25cawzi0	19	29	promoters	promoter	NNS
cord-002407-25cawzi0	19	30	to	to	TO
cord-002407-25cawzi0	19	31	initiate	initiate	VB
cord-002407-25cawzi0	19	32	genome	genome	NN
cord-002407-25cawzi0	19	33	replication	replication	NN
cord-002407-25cawzi0	19	34	and	and	CC
cord-002407-25cawzi0	19	35	gene	gene	NN
cord-002407-25cawzi0	19	36	transcription	transcription	NN
cord-002407-25cawzi0	19	37	by	by	IN
cord-002407-25cawzi0	19	38	the	the	DT
cord-002407-25cawzi0	19	39	viral	viral	JJ
cord-002407-25cawzi0	19	40	polymerase	polymerase	NN
cord-002407-25cawzi0	19	41	complex	complex	NN
cord-002407-25cawzi0	19	42	[	[	-LRB-
cord-002407-25cawzi0	19	43	1	1	CD
cord-002407-25cawzi0	19	44	,	,	,
cord-002407-25cawzi0	19	45	7	7	CD
cord-002407-25cawzi0	19	46	]	]	-RRB-
cord-002407-25cawzi0	19	47	.	.	.
cord-002407-25cawzi0	20	1	Influenza	influenza	NN
cord-002407-25cawzi0	20	2	vRNAs	vRNAs	NNPS
cord-002407-25cawzi0	20	3	in	in	IN
cord-002407-25cawzi0	20	4	the	the	DT
cord-002407-25cawzi0	20	5	virion	virion	NN
cord-002407-25cawzi0	20	6	are	be	VBP
cord-002407-25cawzi0	20	7	found	find	VBN
cord-002407-25cawzi0	20	8	as	as	IN
cord-002407-25cawzi0	20	9	viral	viral	JJ
cord-002407-25cawzi0	20	10	ribonucleoprotein	ribonucleoprotein	NN
cord-002407-25cawzi0	20	11	(	(	-LRB-
cord-002407-25cawzi0	20	12	vRNP	vrnp	NN
cord-002407-25cawzi0	20	13	)	)	-RRB-
cord-002407-25cawzi0	20	14	complexes	complex	NNS
cord-002407-25cawzi0	20	15	encapsidated	encapsidate	VBN
cord-002407-25cawzi0	20	16	by	by	IN
cord-002407-25cawzi0	20	17	the	the	DT
cord-002407-25cawzi0	20	18	viral	viral	JJ
cord-002407-25cawzi0	20	19	nucleoprotein	nucleoprotein	NNP
cord-002407-25cawzi0	20	20	(	(	-LRB-
cord-002407-25cawzi0	20	21	NP	NP	NNP
cord-002407-25cawzi0	20	22	)	)	-RRB-
cord-002407-25cawzi0	20	23	and	and	CC
cord-002407-25cawzi0	20	24	a	a	DT
cord-002407-25cawzi0	20	25	single	single	JJ
cord-002407-25cawzi0	20	26	copy	copy	NN
cord-002407-25cawzi0	20	27	of	of	IN
cord-002407-25cawzi0	20	28	the	the	DT
cord-002407-25cawzi0	20	29	viral	viral	JJ
cord-002407-25cawzi0	20	30	polymerase	polymerase	NN
cord-002407-25cawzi0	20	31	complex	complex	NN
cord-002407-25cawzi0	20	32	.	.	.
cord-002407-25cawzi0	21	1	Influenza	influenza	NN
cord-002407-25cawzi0	21	2	virus	virus	NN
cord-002407-25cawzi0	21	3	-	-	HYPH
cord-002407-25cawzi0	21	4	encoded	encode	VBN
cord-002407-25cawzi0	21	5	RNA	rna	NN
cord-002407-25cawzi0	21	6	-	-	HYPH
cord-002407-25cawzi0	21	7	dependent	dependent	JJ
cord-002407-25cawzi0	21	8	RNA	RNA	NNP
cord-002407-25cawzi0	21	9	polymerase	polymerase	NN
cord-002407-25cawzi0	21	10	(	(	-LRB-
cord-002407-25cawzi0	21	11	RdRp	RdRp	NNP
cord-002407-25cawzi0	21	12	)	)	-RRB-
cord-002407-25cawzi0	22	1	[	[	-LRB-
cord-002407-25cawzi0	22	2	8	8	CD
cord-002407-25cawzi0	22	3	]	]	-RRB-
cord-002407-25cawzi0	22	4	is	be	VBZ
cord-002407-25cawzi0	22	5	a	a	DT
cord-002407-25cawzi0	22	6	trimeric	trimeric	RB
cord-002407-25cawzi0	22	7	complex	complex	JJ
cord-002407-25cawzi0	22	8	consisting	consisting	NN
cord-002407-25cawzi0	22	9	of	of	IN
cord-002407-25cawzi0	22	10	the	the	DT
cord-002407-25cawzi0	22	11	polymerase	polymerase	NN
cord-002407-25cawzi0	22	12	basic	basic	JJ
cord-002407-25cawzi0	22	13	1	1	CD
cord-002407-25cawzi0	22	14	(	(	-LRB-
cord-002407-25cawzi0	22	15	PB1	PB1	NNP
cord-002407-25cawzi0	22	16	)	)	-RRB-
cord-002407-25cawzi0	22	17	and	and	CC
cord-002407-25cawzi0	22	18	2	2	LS
cord-002407-25cawzi0	22	19	(	(	-LRB-
cord-002407-25cawzi0	22	20	PB2	PB2	NNP
cord-002407-25cawzi0	22	21	)	)	-RRB-
cord-002407-25cawzi0	22	22	and	and	CC
cord-002407-25cawzi0	22	23	acidic	acidic	JJ
cord-002407-25cawzi0	22	24	(	(	-LRB-
cord-002407-25cawzi0	22	25	PA	PA	NNP
cord-002407-25cawzi0	22	26	)	)	-RRB-
cord-002407-25cawzi0	22	27	proteins	protein	NNS
cord-002407-25cawzi0	22	28	and	and	CC
cord-002407-25cawzi0	22	29	,	,	,
cord-002407-25cawzi0	22	30	together	together	RB
cord-002407-25cawzi0	22	31	with	with	IN
cord-002407-25cawzi0	22	32	the	the	DT
cord-002407-25cawzi0	22	33	viral	viral	JJ
cord-002407-25cawzi0	22	34	NP	NP	NNP
cord-002407-25cawzi0	22	35	,	,	,
cord-002407-25cawzi0	22	36	are	be	VBP
cord-002407-25cawzi0	22	37	the	the	DT
cord-002407-25cawzi0	22	38	minimal	minimal	JJ
cord-002407-25cawzi0	22	39	components	component	NNS
cord-002407-25cawzi0	22	40	involved	involve	VBN
cord-002407-25cawzi0	22	41	in	in	IN
cord-002407-25cawzi0	22	42	viral	viral	JJ
cord-002407-25cawzi0	22	43	replication	replication	NN
cord-002407-25cawzi0	22	44	and	and	CC
cord-002407-25cawzi0	22	45	transcription	transcription	NN
cord-002407-25cawzi0	22	46	[	[	-LRB-
cord-002407-25cawzi0	22	47	9	9	CD
cord-002407-25cawzi0	22	48	]	]	-RRB-
cord-002407-25cawzi0	22	49	.	.	.
cord-002407-25cawzi0	23	1	IAV	IAV	NNP
cord-002407-25cawzi0	23	2	and	and	CC
cord-002407-25cawzi0	23	3	IBV	IBV	NNP
cord-002407-25cawzi0	23	4	share	share	VBP
cord-002407-25cawzi0	23	5	many	many	JJ
cord-002407-25cawzi0	23	6	features	feature	NNS
cord-002407-25cawzi0	23	7	,	,	,
cord-002407-25cawzi0	23	8	but	but	CC
cord-002407-25cawzi0	23	9	they	-PRON-	PRP
cord-002407-25cawzi0	23	10	differ	differ	VBP
cord-002407-25cawzi0	23	11	in	in	IN
cord-002407-25cawzi0	23	12	their	-PRON-	PRP$
cord-002407-25cawzi0	23	13	host	host	NN
cord-002407-25cawzi0	23	14	range	range	NN
cord-002407-25cawzi0	23	15	,	,	,
cord-002407-25cawzi0	23	16	virion	virion	NN
cord-002407-25cawzi0	23	17	structure	structure	NN
cord-002407-25cawzi0	23	18	,	,	,
cord-002407-25cawzi0	23	19	genomic	genomic	JJ
cord-002407-25cawzi0	23	20	organization	organization	NN
cord-002407-25cawzi0	23	21	and	and	CC
cord-002407-25cawzi0	23	22	glycan	glycan	NN
cord-002407-25cawzi0	23	23	binding	bind	VBG
cord-002407-25cawzi0	23	24	specificities	specificity	NNS
cord-002407-25cawzi0	23	25	[	[	-LRB-
cord-002407-25cawzi0	23	26	1	1	CD
cord-002407-25cawzi0	23	27	,	,	,
cord-002407-25cawzi0	23	28	10	10	CD
cord-002407-25cawzi0	23	29	]	]	-RRB-
cord-002407-25cawzi0	23	30	.	.	.
cord-002407-25cawzi0	24	1	Despite	despite	IN
cord-002407-25cawzi0	24	2	having	have	VBG
cord-002407-25cawzi0	24	3	similar	similar	JJ
cord-002407-25cawzi0	24	4	genomes	genome	NNS
cord-002407-25cawzi0	24	5	encoding	encode	VBG
cord-002407-25cawzi0	24	6	homologous	homologous	JJ
cord-002407-25cawzi0	24	7	proteins	protein	NNS
cord-002407-25cawzi0	24	8	,	,	,
cord-002407-25cawzi0	24	9	IAV	IAV	NNP
cord-002407-25cawzi0	24	10	and	and	CC
cord-002407-25cawzi0	24	11	IBV	IBV	NNP
cord-002407-25cawzi0	24	12	are	be	VBP
cord-002407-25cawzi0	24	13	distinguished	distinguish	VBN
cord-002407-25cawzi0	24	14	by	by	IN
cord-002407-25cawzi0	24	15	the	the	DT
cord-002407-25cawzi0	24	16	different	different	JJ
cord-002407-25cawzi0	24	17	lengths	length	NNS
cord-002407-25cawzi0	24	18	of	of	IN
cord-002407-25cawzi0	24	19	proteins	protein	NNS
cord-002407-25cawzi0	24	20	and	and	CC
cord-002407-25cawzi0	24	21	noncoding	noncoding	JJ
cord-002407-25cawzi0	24	22	regions	region	NNS
cord-002407-25cawzi0	24	23	(	(	-LRB-
cord-002407-25cawzi0	24	24	NCRs	NCRs	NNP
cord-002407-25cawzi0	24	25	)	)	-RRB-
cord-002407-25cawzi0	24	26	that	that	WDT
cord-002407-25cawzi0	24	27	serve	serve	VBP
cord-002407-25cawzi0	24	28	as	as	IN
cord-002407-25cawzi0	24	29	promoters	promoter	NNS
cord-002407-25cawzi0	24	30	for	for	IN
cord-002407-25cawzi0	24	31	genome	genome	NN
cord-002407-25cawzi0	24	32	replication	replication	NN
cord-002407-25cawzi0	24	33	and	and	CC
cord-002407-25cawzi0	24	34	gene	gene	NN
cord-002407-25cawzi0	24	35	transcription	transcription	NN
cord-002407-25cawzi0	24	36	[	[	-LRB-
cord-002407-25cawzi0	24	37	5	5	CD
cord-002407-25cawzi0	24	38	,	,	,
cord-002407-25cawzi0	24	39	11	11	CD
cord-002407-25cawzi0	24	40	,	,	,
cord-002407-25cawzi0	24	41	12	12	CD
cord-002407-25cawzi0	24	42	]	]	-RRB-
cord-002407-25cawzi0	25	1	(	(	-LRB-
cord-002407-25cawzi0	25	2	Figure	figure	NN
cord-002407-25cawzi0	25	3	1	1	CD
cord-002407-25cawzi0	25	4	)	)	-RRB-
cord-002407-25cawzi0	25	5	.	.	.
cord-002407-25cawzi0	26	1	Likewise	likewise	RB
cord-002407-25cawzi0	26	2	,	,	,
cord-002407-25cawzi0	26	3	they	-PRON-	PRP
cord-002407-25cawzi0	26	4	can	can	MD
cord-002407-25cawzi0	26	5	also	also	RB
cord-002407-25cawzi0	26	6	be	be	VB
cord-002407-25cawzi0	26	7	distinguished	distinguish	VBN
cord-002407-25cawzi0	26	8	by	by	IN
cord-002407-25cawzi0	26	9	the	the	DT
cord-002407-25cawzi0	26	10	presence	presence	NN
cord-002407-25cawzi0	26	11	of	of	IN
cord-002407-25cawzi0	26	12	accessory	accessory	NN
cord-002407-25cawzi0	26	13	proteins	protein	NNS
cord-002407-25cawzi0	26	14	encoded	encode	VBN
cord-002407-25cawzi0	26	15	from	from	IN
cord-002407-25cawzi0	26	16	overlapping	overlap	VBG
cord-002407-25cawzi0	26	17	open	open	JJ
cord-002407-25cawzi0	26	18	reading	reading	NN
cord-002407-25cawzi0	26	19	frames	frame	NNS
cord-002407-25cawzi0	26	20	(	(	-LRB-
cord-002407-25cawzi0	26	21	ORFs	ORFs	NNP
cord-002407-25cawzi0	26	22	)	)	-RRB-
cord-002407-25cawzi0	26	23	and	and	CC
cord-002407-25cawzi0	26	24	by	by	IN
cord-002407-25cawzi0	26	25	the	the	DT
cord-002407-25cawzi0	26	26	antigenic	antigenic	JJ
cord-002407-25cawzi0	26	27	differences	difference	NNS
cord-002407-25cawzi0	26	28	of	of	IN
cord-002407-25cawzi0	26	29	internal	internal	JJ
cord-002407-25cawzi0	26	30	proteins	protein	NNS
cord-002407-25cawzi0	26	31	[	[	-LRB-
cord-002407-25cawzi0	26	32	13	13	CD
cord-002407-25cawzi0	26	33	]	]	-RRB-
cord-002407-25cawzi0	26	34	(	(	-LRB-
cord-002407-25cawzi0	26	35	Figure	figure	NN
cord-002407-25cawzi0	26	36	1A	1a	NN
cord-002407-25cawzi0	26	37	,	,	,
cord-002407-25cawzi0	26	38	B	b	NN
cord-002407-25cawzi0	26	39	)	)	-RRB-
cord-002407-25cawzi0	26	40	.	.	.
cord-002407-25cawzi0	27	1	For	for	IN
cord-002407-25cawzi0	27	2	instance	instance	NN
cord-002407-25cawzi0	27	3	,	,	,
cord-002407-25cawzi0	27	4	IAV	IAV	NNP
cord-002407-25cawzi0	27	5	and	and	CC
cord-002407-25cawzi0	27	6	IBV	IBV	NNP
cord-002407-25cawzi0	27	7	both	both	DT
cord-002407-25cawzi0	27	8	encode	encode	VBP
cord-002407-25cawzi0	27	9	ion	ion	NN
cord-002407-25cawzi0	27	10	channel	channel	NN
cord-002407-25cawzi0	27	11	proteins	protein	NNS
cord-002407-25cawzi0	27	12	from	from	IN
cord-002407-25cawzi0	27	13	the	the	DT
cord-002407-25cawzi0	27	14	gene	gene	NN
cord-002407-25cawzi0	27	15	M	M	NNP
cord-002407-25cawzi0	27	16	segment	segment	NN
cord-002407-25cawzi0	27	17	7	7	CD
cord-002407-25cawzi0	27	18	,	,	,
cord-002407-25cawzi0	27	19	M2	M2	NNP
cord-002407-25cawzi0	27	20	and	and	CC
cord-002407-25cawzi0	27	21	BM2	BM2	NNP
cord-002407-25cawzi0	27	22	,	,	,
cord-002407-25cawzi0	27	23	respectively	respectively	RB
cord-002407-25cawzi0	27	24	.	.	.
cord-002407-25cawzi0	28	1	The	the	DT
cord-002407-25cawzi0	28	2	M2	M2	NNP
cord-002407-25cawzi0	28	3	and	and	CC
cord-002407-25cawzi0	28	4	BM2	BM2	NNP
cord-002407-25cawzi0	28	5	proteins	protein	NNS
cord-002407-25cawzi0	28	6	of	of	IN
cord-002407-25cawzi0	28	7	IAV	IAV	NNP
cord-002407-25cawzi0	28	8	or	or	CC
cord-002407-25cawzi0	28	9	IBV	IBV	NNP
cord-002407-25cawzi0	28	10	are	be	VBP
cord-002407-25cawzi0	28	11	encoded	encode	VBN
cord-002407-25cawzi0	28	12	together	together	RB
cord-002407-25cawzi0	28	13	with	with	IN
cord-002407-25cawzi0	28	14	the	the	DT
cord-002407-25cawzi0	28	15	matrix	matrix	NN
cord-002407-25cawzi0	28	16	protein	protein	NN
cord-002407-25cawzi0	28	17	1	1	CD
cord-002407-25cawzi0	28	18	(	(	-LRB-
cord-002407-25cawzi0	28	19	M1	M1	NNP
cord-002407-25cawzi0	28	20	)	)	-RRB-
cord-002407-25cawzi0	28	21	and	and	CC
cord-002407-25cawzi0	28	22	both	both	DT
cord-002407-25cawzi0	28	23	are	be	VBP
cord-002407-25cawzi0	28	24	incorporated	incorporate	VBN
cord-002407-25cawzi0	28	25	into	into	IN
cord-002407-25cawzi0	28	26	virions	virion	NNS
cord-002407-25cawzi0	28	27	and	and	CC
cord-002407-25cawzi0	28	28	expressed	express	VBN
cord-002407-25cawzi0	28	29	on	on	IN
cord-002407-25cawzi0	28	30	the	the	DT
cord-002407-25cawzi0	28	31	surface	surface	NN
cord-002407-25cawzi0	28	32	of	of	IN
cord-002407-25cawzi0	28	33	virus	virus	NN
cord-002407-25cawzi0	28	34	-	-	HYPH
cord-002407-25cawzi0	28	35	infected	infect	VBN
cord-002407-25cawzi0	28	36	cells	cell	NNS
cord-002407-25cawzi0	28	37	[	[	-LRB-
cord-002407-25cawzi0	28	38	1	1	CD
cord-002407-25cawzi0	28	39	]	]	-RRB-
cord-002407-25cawzi0	28	40	.	.	.
cord-002407-25cawzi0	29	1	However	however	RB
cord-002407-25cawzi0	29	2	,	,	,
cord-002407-25cawzi0	29	3	the	the	DT
cord-002407-25cawzi0	29	4	M2	M2	NNP
cord-002407-25cawzi0	29	5	protein	protein	NN
cord-002407-25cawzi0	29	6	of	of	IN
cord-002407-25cawzi0	29	7	IAV	IAV	NNP
cord-002407-25cawzi0	29	8	is	be	VBZ
cord-002407-25cawzi0	29	9	translated	translate	VBN
cord-002407-25cawzi0	29	10	from	from	IN
cord-002407-25cawzi0	29	11	a	a	DT
cord-002407-25cawzi0	29	12	spliced	splice	VBN
cord-002407-25cawzi0	29	13	mRNA	mrna	NN
cord-002407-25cawzi0	29	14	[	[	-LRB-
cord-002407-25cawzi0	29	15	14	14	CD
cord-002407-25cawzi0	29	16	]	]	-RRB-
cord-002407-25cawzi0	29	17	,	,	,
cord-002407-25cawzi0	29	18	while	while	IN
cord-002407-25cawzi0	29	19	the	the	DT
cord-002407-25cawzi0	29	20	IBV	IBV	NNP
cord-002407-25cawzi0	29	21	BM2	BM2	NNP
cord-002407-25cawzi0	29	22	protein	protein	NN
cord-002407-25cawzi0	29	23	is	be	VBZ
cord-002407-25cawzi0	29	24	translated	translate	VBN
cord-002407-25cawzi0	29	25	using	use	VBG
cord-002407-25cawzi0	29	26	a	a	DT
cord-002407-25cawzi0	29	27	different	different	JJ
cord-002407-25cawzi0	29	28	strategy	strategy	NN
cord-002407-25cawzi0	29	29	,	,	,
cord-002407-25cawzi0	29	30	where	where	WRB
cord-002407-25cawzi0	29	31	the	the	DT
cord-002407-25cawzi0	29	32	initiation	initiation	NN
cord-002407-25cawzi0	29	33	codon	codon	NN
cord-002407-25cawzi0	29	34	of	of	IN
cord-002407-25cawzi0	29	35	BM2	BM2	NNP
cord-002407-25cawzi0	29	36	protein	protein	NN
cord-002407-25cawzi0	29	37	overlaps	overlap	VBZ
cord-002407-25cawzi0	29	38	the	the	DT
cord-002407-25cawzi0	29	39	termination	termination	NN
cord-002407-25cawzi0	29	40	codon	codon	NN
cord-002407-25cawzi0	29	41	of	of	IN
cord-002407-25cawzi0	29	42	M1	M1	NNP
cord-002407-25cawzi0	29	43	protein	protein	NN
cord-002407-25cawzi0	29	44	(	(	-LRB-
cord-002407-25cawzi0	29	45	UAAUG	UAAUG	NNP
cord-002407-25cawzi0	29	46	,	,	,
cord-002407-25cawzi0	29	47	a	a	DT
cord-002407-25cawzi0	29	48	stop	stop	VB
cord-002407-25cawzi0	29	49	-	-	HYPH
cord-002407-25cawzi0	29	50	start	start	NN
cord-002407-25cawzi0	29	51	pentanucleotide	pentanucleotide	NN
cord-002407-25cawzi0	29	52	)	)	-RRB-
cord-002407-25cawzi0	29	53	[	[	-LRB-
cord-002407-25cawzi0	29	54	15	15	CD
cord-002407-25cawzi0	29	55	]	]	-RRB-
cord-002407-25cawzi0	29	56	.	.	.
cord-002407-25cawzi0	30	1	In	in	IN
cord-002407-25cawzi0	30	2	addition	addition	NN
cord-002407-25cawzi0	30	3	,	,	,
cord-002407-25cawzi0	30	4	IBV	IBV	NNP
cord-002407-25cawzi0	30	5	expresses	express	VBZ
cord-002407-25cawzi0	30	6	the	the	DT
cord-002407-25cawzi0	30	7	NB	NB	NNP
cord-002407-25cawzi0	30	8	ion	ion	NN
cord-002407-25cawzi0	30	9	channel	channel	NN
cord-002407-25cawzi0	30	10	,	,	,
cord-002407-25cawzi0	30	11	which	which	WDT
cord-002407-25cawzi0	30	12	is	be	VBZ
cord-002407-25cawzi0	30	13	absent	absent	JJ
cord-002407-25cawzi0	30	14	in	in	IN
cord-002407-25cawzi0	30	15	type	type	NN
cord-002407-25cawzi0	30	16	A	a	DT
cord-002407-25cawzi0	30	17	influenza	influenza	NN
cord-002407-25cawzi0	30	18	virus	virus	NN
cord-002407-25cawzi0	30	19	[	[	-LRB-
cord-002407-25cawzi0	30	20	1	1	CD
cord-002407-25cawzi0	30	21	]	]	-RRB-
cord-002407-25cawzi0	30	22	(	(	-LRB-
cord-002407-25cawzi0	30	23	Figure	figure	NN
cord-002407-25cawzi0	30	24	1B	1b	CD
cord-002407-25cawzi0	30	25	)	)	-RRB-
cord-002407-25cawzi0	30	26	.	.	.
cord-002407-25cawzi0	31	1	However	however	RB
cord-002407-25cawzi0	31	2	,	,	,
cord-002407-25cawzi0	31	3	both	both	DT
cord-002407-25cawzi0	31	4	influenza	influenza	NN
cord-002407-25cawzi0	31	5	viruses	virus	NNS
cord-002407-25cawzi0	31	6	encode	encode	VBP
cord-002407-25cawzi0	31	7	two	two	CD
cord-002407-25cawzi0	31	8	surface	surface	NN
cord-002407-25cawzi0	31	9	glycoproteins	glycoprotein	NNS
cord-002407-25cawzi0	31	10	,	,	,
cord-002407-25cawzi0	31	11	hemagglutinin	hemagglutinin	NNS
cord-002407-25cawzi0	31	12	(	(	-LRB-
cord-002407-25cawzi0	31	13	HA	HA	NNP
cord-002407-25cawzi0	31	14	)	)	-RRB-
cord-002407-25cawzi0	31	15	and	and	CC
cord-002407-25cawzi0	31	16	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	31	17	(	(	-LRB-
cord-002407-25cawzi0	31	18	NA	NA	NNP
cord-002407-25cawzi0	31	19	)	)	-RRB-
cord-002407-25cawzi0	31	20	(	(	-LRB-
cord-002407-25cawzi0	31	21	Figure	figure	NN
cord-002407-25cawzi0	31	22	1A	1a	NN
cord-002407-25cawzi0	31	23	,	,	,
cord-002407-25cawzi0	31	24	B	b	NN
cord-002407-25cawzi0	31	25	)	)	-RRB-
cord-002407-25cawzi0	31	26	.	.	.
cord-002407-25cawzi0	32	1	IAV	IAV	NNP
cord-002407-25cawzi0	32	2	and	and	CC
cord-002407-25cawzi0	32	3	IBV	IBV	NNP
cord-002407-25cawzi0	32	4	HA	HA	NNP
cord-002407-25cawzi0	32	5	proteins	protein	NNS
cord-002407-25cawzi0	32	6	are	be	VBP
cord-002407-25cawzi0	32	7	involved	involve	VBN
cord-002407-25cawzi0	32	8	in	in	IN
cord-002407-25cawzi0	32	9	binding	bind	VBG
cord-002407-25cawzi0	32	10	to	to	IN
cord-002407-25cawzi0	32	11	cellular	cellular	JJ
cord-002407-25cawzi0	32	12	receptors	receptor	NNS
cord-002407-25cawzi0	32	13	and	and	CC
cord-002407-25cawzi0	32	14	responsible	responsible	JJ
cord-002407-25cawzi0	32	15	for	for	IN
cord-002407-25cawzi0	32	16	the	the	DT
cord-002407-25cawzi0	32	17	fusion	fusion	NN
cord-002407-25cawzi0	32	18	of	of	IN
cord-002407-25cawzi0	32	19	the	the	DT
cord-002407-25cawzi0	32	20	viral	viral	JJ
cord-002407-25cawzi0	32	21	and	and	CC
cord-002407-25cawzi0	32	22	endosomal	endosomal	JJ
cord-002407-25cawzi0	32	23	membranes	membrane	NNS
cord-002407-25cawzi0	32	24	[	[	-LRB-
cord-002407-25cawzi0	32	25	16	16	CD
cord-002407-25cawzi0	32	26	]	]	-RRB-
cord-002407-25cawzi0	32	27	.	.	.
cord-002407-25cawzi0	33	1	Infection	infection	NN
cord-002407-25cawzi0	33	2	with	with	IN
cord-002407-25cawzi0	33	3	IAV	IAV	NNP
cord-002407-25cawzi0	33	4	or	or	CC
cord-002407-25cawzi0	33	5	IBV	IBV	NNP
cord-002407-25cawzi0	33	6	induces	induce	VBZ
cord-002407-25cawzi0	33	7	a	a	DT
cord-002407-25cawzi0	33	8	protective	protective	JJ
cord-002407-25cawzi0	33	9	immunity	immunity	NN
cord-002407-25cawzi0	33	10	mediated	mediate	VBN
cord-002407-25cawzi0	33	11	,	,	,
cord-002407-25cawzi0	33	12	at	at	IN
cord-002407-25cawzi0	33	13	least	least	JJS
cord-002407-25cawzi0	33	14	partially	partially	RB
cord-002407-25cawzi0	33	15	,	,	,
cord-002407-25cawzi0	33	16	by	by	IN
cord-002407-25cawzi0	33	17	antibodies	antibody	NNS
cord-002407-25cawzi0	33	18	directed	direct	VBN
cord-002407-25cawzi0	33	19	against	against	IN
cord-002407-25cawzi0	33	20	the	the	DT
cord-002407-25cawzi0	33	21	viral	viral	JJ
cord-002407-25cawzi0	33	22	HA	HA	NNP
cord-002407-25cawzi0	33	23	,	,	,
cord-002407-25cawzi0	33	24	which	which	WDT
cord-002407-25cawzi0	33	25	is	be	VBZ
cord-002407-25cawzi0	33	26	the	the	DT
cord-002407-25cawzi0	33	27	main	main	JJ
cord-002407-25cawzi0	33	28	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	33	29	target	target	NN
cord-002407-25cawzi0	33	30	in	in	IN
cord-002407-25cawzi0	33	31	both	both	DT
cord-002407-25cawzi0	33	32	natural	natural	JJ
cord-002407-25cawzi0	33	33	infections	infection	NNS
cord-002407-25cawzi0	33	34	and	and	CC
cord-002407-25cawzi0	33	35	vaccine	vaccine	NN
cord-002407-25cawzi0	33	36	approaches	approach	NNS
cord-002407-25cawzi0	33	37	.	.	.
cord-002407-25cawzi0	34	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	34	2	NA	NA	NNP
cord-002407-25cawzi0	34	3	glycoprotein	glycoprotein	NN
cord-002407-25cawzi0	34	4	is	be	VBZ
cord-002407-25cawzi0	34	5	responsible	responsible	JJ
cord-002407-25cawzi0	34	6	for	for	IN
cord-002407-25cawzi0	34	7	the	the	DT
cord-002407-25cawzi0	34	8	cleavage	cleavage	NN
cord-002407-25cawzi0	34	9	of	of	IN
cord-002407-25cawzi0	34	10	sialic	sialic	JJ
cord-002407-25cawzi0	34	11	acid	acid	NN
cord-002407-25cawzi0	34	12	moieties	moiety	NNS
cord-002407-25cawzi0	34	13	from	from	IN
cord-002407-25cawzi0	34	14	IAV	IAV	NNP
cord-002407-25cawzi0	34	15	and	and	CC
cord-002407-25cawzi0	34	16	IBV	IBV	NNP
cord-002407-25cawzi0	34	17	share	share	VBP
cord-002407-25cawzi0	34	18	many	many	JJ
cord-002407-25cawzi0	34	19	features	feature	NNS
cord-002407-25cawzi0	34	20	,	,	,
cord-002407-25cawzi0	34	21	but	but	CC
cord-002407-25cawzi0	34	22	they	-PRON-	PRP
cord-002407-25cawzi0	34	23	differ	differ	VBP
cord-002407-25cawzi0	34	24	in	in	IN
cord-002407-25cawzi0	34	25	their	-PRON-	PRP$
cord-002407-25cawzi0	34	26	host	host	NN
cord-002407-25cawzi0	34	27	range	range	NN
cord-002407-25cawzi0	34	28	,	,	,
cord-002407-25cawzi0	34	29	virion	virion	NN
cord-002407-25cawzi0	34	30	structure	structure	NN
cord-002407-25cawzi0	34	31	,	,	,
cord-002407-25cawzi0	34	32	genomic	genomic	JJ
cord-002407-25cawzi0	34	33	organization	organization	NN
cord-002407-25cawzi0	34	34	and	and	CC
cord-002407-25cawzi0	34	35	glycan	glycan	NN
cord-002407-25cawzi0	34	36	binding	bind	VBG
cord-002407-25cawzi0	34	37	specificities	specificity	NNS
cord-002407-25cawzi0	34	38	[	[	-LRB-
cord-002407-25cawzi0	34	39	1	1	CD
cord-002407-25cawzi0	34	40	,	,	,
cord-002407-25cawzi0	34	41	10	10	CD
cord-002407-25cawzi0	34	42	]	]	-RRB-
cord-002407-25cawzi0	34	43	.	.	.
cord-002407-25cawzi0	35	1	Despite	despite	IN
cord-002407-25cawzi0	35	2	having	have	VBG
cord-002407-25cawzi0	35	3	similar	similar	JJ
cord-002407-25cawzi0	35	4	genomes	genome	NNS
cord-002407-25cawzi0	35	5	encoding	encode	VBG
cord-002407-25cawzi0	35	6	homologous	homologous	JJ
cord-002407-25cawzi0	35	7	proteins	protein	NNS
cord-002407-25cawzi0	35	8	,	,	,
cord-002407-25cawzi0	35	9	IAV	IAV	NNP
cord-002407-25cawzi0	35	10	and	and	CC
cord-002407-25cawzi0	35	11	IBV	IBV	NNP
cord-002407-25cawzi0	35	12	are	be	VBP
cord-002407-25cawzi0	35	13	distinguished	distinguish	VBN
cord-002407-25cawzi0	35	14	by	by	IN
cord-002407-25cawzi0	35	15	the	the	DT
cord-002407-25cawzi0	35	16	different	different	JJ
cord-002407-25cawzi0	35	17	lengths	length	NNS
cord-002407-25cawzi0	35	18	of	of	IN
cord-002407-25cawzi0	35	19	proteins	protein	NNS
cord-002407-25cawzi0	35	20	and	and	CC
cord-002407-25cawzi0	35	21	non	non	JJ
cord-002407-25cawzi0	35	22	-	-	JJ
cord-002407-25cawzi0	35	23	coding	coding	JJ
cord-002407-25cawzi0	35	24	regions	region	NNS
cord-002407-25cawzi0	35	25	(	(	-LRB-
cord-002407-25cawzi0	35	26	NCRs	NCRs	NNP
cord-002407-25cawzi0	35	27	)	)	-RRB-
cord-002407-25cawzi0	35	28	that	that	WDT
cord-002407-25cawzi0	35	29	serve	serve	VBP
cord-002407-25cawzi0	35	30	as	as	IN
cord-002407-25cawzi0	35	31	promoters	promoter	NNS
cord-002407-25cawzi0	35	32	for	for	IN
cord-002407-25cawzi0	35	33	genome	genome	NN
cord-002407-25cawzi0	35	34	replication	replication	NN
cord-002407-25cawzi0	35	35	and	and	CC
cord-002407-25cawzi0	35	36	gene	gene	NN
cord-002407-25cawzi0	35	37	transcription	transcription	NN
cord-002407-25cawzi0	35	38	[	[	-LRB-
cord-002407-25cawzi0	35	39	5	5	CD
cord-002407-25cawzi0	35	40	,	,	,
cord-002407-25cawzi0	35	41	11	11	CD
cord-002407-25cawzi0	35	42	,	,	,
cord-002407-25cawzi0	35	43	12	12	CD
cord-002407-25cawzi0	35	44	]	]	-RRB-
cord-002407-25cawzi0	36	1	(	(	-LRB-
cord-002407-25cawzi0	36	2	Figure	figure	NN
cord-002407-25cawzi0	36	3	1	1	CD
cord-002407-25cawzi0	36	4	)	)	-RRB-
cord-002407-25cawzi0	36	5	.	.	.
cord-002407-25cawzi0	37	1	Likewise	likewise	RB
cord-002407-25cawzi0	37	2	,	,	,
cord-002407-25cawzi0	37	3	they	-PRON-	PRP
cord-002407-25cawzi0	37	4	can	can	MD
cord-002407-25cawzi0	37	5	also	also	RB
cord-002407-25cawzi0	37	6	be	be	VB
cord-002407-25cawzi0	37	7	distinguished	distinguish	VBN
cord-002407-25cawzi0	37	8	by	by	IN
cord-002407-25cawzi0	37	9	the	the	DT
cord-002407-25cawzi0	37	10	presence	presence	NN
cord-002407-25cawzi0	37	11	of	of	IN
cord-002407-25cawzi0	37	12	accessory	accessory	NN
cord-002407-25cawzi0	37	13	proteins	protein	NNS
cord-002407-25cawzi0	37	14	encoded	encode	VBN
cord-002407-25cawzi0	37	15	from	from	IN
cord-002407-25cawzi0	37	16	overlapping	overlap	VBG
cord-002407-25cawzi0	37	17	open	open	JJ
cord-002407-25cawzi0	37	18	reading	reading	NN
cord-002407-25cawzi0	37	19	frames	frame	NNS
cord-002407-25cawzi0	37	20	(	(	-LRB-
cord-002407-25cawzi0	37	21	ORFs	ORFs	NNP
cord-002407-25cawzi0	37	22	)	)	-RRB-
cord-002407-25cawzi0	37	23	and	and	CC
cord-002407-25cawzi0	37	24	by	by	IN
cord-002407-25cawzi0	37	25	the	the	DT
cord-002407-25cawzi0	37	26	antigenic	antigenic	JJ
cord-002407-25cawzi0	37	27	differences	difference	NNS
cord-002407-25cawzi0	37	28	of	of	IN
cord-002407-25cawzi0	37	29	internal	internal	JJ
cord-002407-25cawzi0	37	30	proteins	protein	NNS
cord-002407-25cawzi0	37	31	[	[	-LRB-
cord-002407-25cawzi0	37	32	13	13	CD
cord-002407-25cawzi0	37	33	]	]	-RRB-
cord-002407-25cawzi0	37	34	(	(	-LRB-
cord-002407-25cawzi0	37	35	Figure	figure	NN
cord-002407-25cawzi0	37	36	1A	1a	NN
cord-002407-25cawzi0	37	37	,	,	,
cord-002407-25cawzi0	37	38	B	b	NN
cord-002407-25cawzi0	37	39	)	)	-RRB-
cord-002407-25cawzi0	37	40	.	.	.
cord-002407-25cawzi0	38	1	For	for	IN
cord-002407-25cawzi0	38	2	instance	instance	NN
cord-002407-25cawzi0	38	3	,	,	,
cord-002407-25cawzi0	38	4	IAV	IAV	NNP
cord-002407-25cawzi0	38	5	and	and	CC
cord-002407-25cawzi0	38	6	IBV	IBV	NNP
cord-002407-25cawzi0	38	7	both	both	DT
cord-002407-25cawzi0	38	8	encode	encode	VBP
cord-002407-25cawzi0	38	9	ion	ion	NN
cord-002407-25cawzi0	38	10	channel	channel	NN
cord-002407-25cawzi0	38	11	proteins	protein	NNS
cord-002407-25cawzi0	38	12	from	from	IN
cord-002407-25cawzi0	38	13	the	the	DT
cord-002407-25cawzi0	38	14	gene	gene	NN
cord-002407-25cawzi0	38	15	M	M	NNP
cord-002407-25cawzi0	38	16	segment	segment	NN
cord-002407-25cawzi0	38	17	7	7	CD
cord-002407-25cawzi0	38	18	,	,	,
cord-002407-25cawzi0	38	19	M2	M2	NNP
cord-002407-25cawzi0	38	20	and	and	CC
cord-002407-25cawzi0	38	21	BM2	BM2	NNP
cord-002407-25cawzi0	38	22	,	,	,
cord-002407-25cawzi0	38	23	respectively	respectively	RB
cord-002407-25cawzi0	38	24	.	.	.
cord-002407-25cawzi0	39	1	The	the	DT
cord-002407-25cawzi0	39	2	M2	M2	NNP
cord-002407-25cawzi0	39	3	and	and	CC
cord-002407-25cawzi0	39	4	BM2	BM2	NNP
cord-002407-25cawzi0	39	5	proteins	protein	NNS
cord-002407-25cawzi0	39	6	of	of	IN
cord-002407-25cawzi0	39	7	IAV	IAV	NNP
cord-002407-25cawzi0	39	8	or	or	CC
cord-002407-25cawzi0	39	9	IBV	IBV	NNP
cord-002407-25cawzi0	39	10	are	be	VBP
cord-002407-25cawzi0	39	11	encoded	encode	VBN
cord-002407-25cawzi0	39	12	together	together	RB
cord-002407-25cawzi0	39	13	with	with	IN
cord-002407-25cawzi0	39	14	the	the	DT
cord-002407-25cawzi0	39	15	matrix	matrix	NN
cord-002407-25cawzi0	39	16	protein	protein	NN
cord-002407-25cawzi0	39	17	1	1	CD
cord-002407-25cawzi0	39	18	(	(	-LRB-
cord-002407-25cawzi0	39	19	M1	M1	NNP
cord-002407-25cawzi0	39	20	)	)	-RRB-
cord-002407-25cawzi0	39	21	and	and	CC
cord-002407-25cawzi0	39	22	both	both	DT
cord-002407-25cawzi0	39	23	are	be	VBP
cord-002407-25cawzi0	39	24	incorporated	incorporate	VBN
cord-002407-25cawzi0	39	25	into	into	IN
cord-002407-25cawzi0	39	26	virions	virion	NNS
cord-002407-25cawzi0	39	27	and	and	CC
cord-002407-25cawzi0	39	28	expressed	express	VBN
cord-002407-25cawzi0	39	29	on	on	IN
cord-002407-25cawzi0	39	30	the	the	DT
cord-002407-25cawzi0	39	31	surface	surface	NN
cord-002407-25cawzi0	39	32	of	of	IN
cord-002407-25cawzi0	39	33	virus	virus	NN
cord-002407-25cawzi0	39	34	-	-	HYPH
cord-002407-25cawzi0	39	35	infected	infect	VBN
cord-002407-25cawzi0	39	36	cells	cell	NNS
cord-002407-25cawzi0	39	37	[	[	-LRB-
cord-002407-25cawzi0	39	38	1	1	CD
cord-002407-25cawzi0	39	39	]	]	-RRB-
cord-002407-25cawzi0	39	40	.	.	.
cord-002407-25cawzi0	40	1	However	however	RB
cord-002407-25cawzi0	40	2	,	,	,
cord-002407-25cawzi0	40	3	the	the	DT
cord-002407-25cawzi0	40	4	M2	M2	NNP
cord-002407-25cawzi0	40	5	protein	protein	NN
cord-002407-25cawzi0	40	6	of	of	IN
cord-002407-25cawzi0	40	7	IAV	IAV	NNP
cord-002407-25cawzi0	40	8	is	be	VBZ
cord-002407-25cawzi0	40	9	translated	translate	VBN
cord-002407-25cawzi0	40	10	from	from	IN
cord-002407-25cawzi0	40	11	a	a	DT
cord-002407-25cawzi0	40	12	spliced	splice	VBN
cord-002407-25cawzi0	40	13	mRNA	mrna	NN
cord-002407-25cawzi0	40	14	[	[	-LRB-
cord-002407-25cawzi0	40	15	14	14	CD
cord-002407-25cawzi0	40	16	]	]	-RRB-
cord-002407-25cawzi0	40	17	,	,	,
cord-002407-25cawzi0	40	18	while	while	IN
cord-002407-25cawzi0	40	19	the	the	DT
cord-002407-25cawzi0	40	20	IBV	IBV	NNP
cord-002407-25cawzi0	40	21	BM2	BM2	NNP
cord-002407-25cawzi0	40	22	protein	protein	NN
cord-002407-25cawzi0	40	23	is	be	VBZ
cord-002407-25cawzi0	40	24	translated	translate	VBN
cord-002407-25cawzi0	40	25	using	use	VBG
cord-002407-25cawzi0	40	26	a	a	DT
cord-002407-25cawzi0	40	27	different	different	JJ
cord-002407-25cawzi0	40	28	strategy	strategy	NN
cord-002407-25cawzi0	40	29	,	,	,
cord-002407-25cawzi0	40	30	where	where	WRB
cord-002407-25cawzi0	40	31	the	the	DT
cord-002407-25cawzi0	40	32	initiation	initiation	NN
cord-002407-25cawzi0	40	33	codon	codon	NN
cord-002407-25cawzi0	40	34	of	of	IN
cord-002407-25cawzi0	40	35	BM2	BM2	NNP
cord-002407-25cawzi0	40	36	protein	protein	NN
cord-002407-25cawzi0	40	37	overlaps	overlap	VBZ
cord-002407-25cawzi0	40	38	the	the	DT
cord-002407-25cawzi0	40	39	termination	termination	NN
cord-002407-25cawzi0	40	40	codon	codon	NN
cord-002407-25cawzi0	40	41	of	of	IN
cord-002407-25cawzi0	40	42	M1	M1	NNP
cord-002407-25cawzi0	40	43	protein	protein	NN
cord-002407-25cawzi0	40	44	(	(	-LRB-
cord-002407-25cawzi0	40	45	UAAUG	UAAUG	NNP
cord-002407-25cawzi0	40	46	,	,	,
cord-002407-25cawzi0	40	47	a	a	DT
cord-002407-25cawzi0	40	48	stop	stop	VB
cord-002407-25cawzi0	40	49	-	-	HYPH
cord-002407-25cawzi0	40	50	start	start	NN
cord-002407-25cawzi0	40	51	pentanucleotide	pentanucleotide	NN
cord-002407-25cawzi0	40	52	)	)	-RRB-
cord-002407-25cawzi0	40	53	[	[	-LRB-
cord-002407-25cawzi0	40	54	15	15	CD
cord-002407-25cawzi0	40	55	]	]	-RRB-
cord-002407-25cawzi0	40	56	.	.	.
cord-002407-25cawzi0	41	1	In	in	IN
cord-002407-25cawzi0	41	2	addition	addition	NN
cord-002407-25cawzi0	41	3	,	,	,
cord-002407-25cawzi0	41	4	IBV	IBV	NNP
cord-002407-25cawzi0	41	5	expresses	express	VBZ
cord-002407-25cawzi0	41	6	the	the	DT
cord-002407-25cawzi0	41	7	NB	NB	NNP
cord-002407-25cawzi0	41	8	ion	ion	NN
cord-002407-25cawzi0	41	9	channel	channel	NN
cord-002407-25cawzi0	41	10	,	,	,
cord-002407-25cawzi0	41	11	which	which	WDT
cord-002407-25cawzi0	41	12	is	be	VBZ
cord-002407-25cawzi0	41	13	absent	absent	JJ
cord-002407-25cawzi0	41	14	in	in	IN
cord-002407-25cawzi0	41	15	type	type	NN
cord-002407-25cawzi0	41	16	A	a	DT
cord-002407-25cawzi0	41	17	influenza	influenza	NN
cord-002407-25cawzi0	41	18	virus	virus	NN
cord-002407-25cawzi0	41	19	[	[	-LRB-
cord-002407-25cawzi0	41	20	1	1	CD
cord-002407-25cawzi0	41	21	]	]	-RRB-
cord-002407-25cawzi0	41	22	(	(	-LRB-
cord-002407-25cawzi0	41	23	Figure	figure	NN
cord-002407-25cawzi0	41	24	1B	1b	CD
cord-002407-25cawzi0	41	25	)	)	-RRB-
cord-002407-25cawzi0	41	26	.	.	.
cord-002407-25cawzi0	42	1	However	however	RB
cord-002407-25cawzi0	42	2	,	,	,
cord-002407-25cawzi0	42	3	both	both	DT
cord-002407-25cawzi0	42	4	influenza	influenza	NN
cord-002407-25cawzi0	42	5	viruses	virus	NNS
cord-002407-25cawzi0	42	6	encode	encode	VBP
cord-002407-25cawzi0	42	7	two	two	CD
cord-002407-25cawzi0	42	8	surface	surface	NN
cord-002407-25cawzi0	42	9	glycoproteins	glycoprotein	NNS
cord-002407-25cawzi0	42	10	,	,	,
cord-002407-25cawzi0	42	11	hemagglutinin	hemagglutinin	NNS
cord-002407-25cawzi0	42	12	(	(	-LRB-
cord-002407-25cawzi0	42	13	HA	HA	NNP
cord-002407-25cawzi0	42	14	)	)	-RRB-
cord-002407-25cawzi0	42	15	and	and	CC
cord-002407-25cawzi0	42	16	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	42	17	(	(	-LRB-
cord-002407-25cawzi0	42	18	NA	NA	NNP
cord-002407-25cawzi0	42	19	)	)	-RRB-
cord-002407-25cawzi0	42	20	(	(	-LRB-
cord-002407-25cawzi0	42	21	Figure	figure	NN
cord-002407-25cawzi0	42	22	1A	1a	NN
cord-002407-25cawzi0	42	23	,	,	,
cord-002407-25cawzi0	42	24	B	b	NN
cord-002407-25cawzi0	42	25	)	)	-RRB-
cord-002407-25cawzi0	42	26	.	.	.
cord-002407-25cawzi0	43	1	IAV	IAV	NNP
cord-002407-25cawzi0	43	2	and	and	CC
cord-002407-25cawzi0	43	3	IBV	IBV	NNP
cord-002407-25cawzi0	43	4	HA	HA	NNP
cord-002407-25cawzi0	43	5	proteins	protein	NNS
cord-002407-25cawzi0	43	6	are	be	VBP
cord-002407-25cawzi0	43	7	involved	involve	VBN
cord-002407-25cawzi0	43	8	in	in	IN
cord-002407-25cawzi0	43	9	binding	bind	VBG
cord-002407-25cawzi0	43	10	to	to	IN
cord-002407-25cawzi0	43	11	cellular	cellular	JJ
cord-002407-25cawzi0	43	12	receptors	receptor	NNS
cord-002407-25cawzi0	43	13	and	and	CC
cord-002407-25cawzi0	43	14	responsible	responsible	JJ
cord-002407-25cawzi0	43	15	for	for	IN
cord-002407-25cawzi0	43	16	the	the	DT
cord-002407-25cawzi0	43	17	fusion	fusion	NN
cord-002407-25cawzi0	43	18	of	of	IN
cord-002407-25cawzi0	43	19	the	the	DT
cord-002407-25cawzi0	43	20	viral	viral	JJ
cord-002407-25cawzi0	43	21	and	and	CC
cord-002407-25cawzi0	43	22	endosomal	endosomal	JJ
cord-002407-25cawzi0	43	23	membranes	membrane	NNS
cord-002407-25cawzi0	43	24	[	[	-LRB-
cord-002407-25cawzi0	43	25	16	16	CD
cord-002407-25cawzi0	43	26	]	]	-RRB-
cord-002407-25cawzi0	43	27	.	.	.
cord-002407-25cawzi0	44	1	Infection	infection	NN
cord-002407-25cawzi0	44	2	with	with	IN
cord-002407-25cawzi0	44	3	IAV	IAV	NNP
cord-002407-25cawzi0	44	4	or	or	CC
cord-002407-25cawzi0	44	5	IBV	IBV	NNP
cord-002407-25cawzi0	44	6	induces	induce	VBZ
cord-002407-25cawzi0	44	7	a	a	DT
cord-002407-25cawzi0	44	8	protective	protective	JJ
cord-002407-25cawzi0	44	9	immunity	immunity	NN
cord-002407-25cawzi0	44	10	mediated	mediate	VBN
cord-002407-25cawzi0	44	11	,	,	,
cord-002407-25cawzi0	44	12	at	at	IN
cord-002407-25cawzi0	44	13	least	least	JJS
cord-002407-25cawzi0	44	14	partially	partially	RB
cord-002407-25cawzi0	44	15	,	,	,
cord-002407-25cawzi0	44	16	by	by	IN
cord-002407-25cawzi0	44	17	antibodies	antibody	NNS
cord-002407-25cawzi0	44	18	directed	direct	VBN
cord-002407-25cawzi0	44	19	against	against	IN
cord-002407-25cawzi0	44	20	the	the	DT
cord-002407-25cawzi0	44	21	viral	viral	JJ
cord-002407-25cawzi0	44	22	HA	HA	NNP
cord-002407-25cawzi0	44	23	,	,	,
cord-002407-25cawzi0	44	24	which	which	WDT
cord-002407-25cawzi0	44	25	is	be	VBZ
cord-002407-25cawzi0	44	26	the	the	DT
cord-002407-25cawzi0	44	27	main	main	JJ
cord-002407-25cawzi0	44	28	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	44	29	target	target	NN
cord-002407-25cawzi0	44	30	in	in	IN
cord-002407-25cawzi0	44	31	both	both	DT
cord-002407-25cawzi0	44	32	natural	natural	JJ
cord-002407-25cawzi0	44	33	infections	infection	NNS
cord-002407-25cawzi0	44	34	and	and	CC
cord-002407-25cawzi0	44	35	vaccine	vaccine	NN
cord-002407-25cawzi0	44	36	approaches	approach	NNS
cord-002407-25cawzi0	44	37	.	.	.
cord-002407-25cawzi0	45	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	45	2	NA	NA	NNP
cord-002407-25cawzi0	45	3	glycoprotein	glycoprotein	NN
cord-002407-25cawzi0	45	4	is	be	VBZ
cord-002407-25cawzi0	45	5	responsible	responsible	JJ
cord-002407-25cawzi0	45	6	for	for	IN
cord-002407-25cawzi0	45	7	the	the	DT
cord-002407-25cawzi0	45	8	cleavage	cleavage	NN
cord-002407-25cawzi0	45	9	of	of	IN
cord-002407-25cawzi0	45	10	sialic	sialic	JJ
cord-002407-25cawzi0	45	11	acid	acid	NN
cord-002407-25cawzi0	45	12	moieties	moiety	NNS
cord-002407-25cawzi0	45	13	from	from	IN
cord-002407-25cawzi0	45	14	sialyloligosaccharides	sialyloligosaccharide	NNS
cord-002407-25cawzi0	45	15	and	and	CC
cord-002407-25cawzi0	45	16	facilitates	facilitate	VBZ
cord-002407-25cawzi0	45	17	the	the	DT
cord-002407-25cawzi0	45	18	release	release	NN
cord-002407-25cawzi0	45	19	of	of	IN
cord-002407-25cawzi0	45	20	newly	newly	RB
cord-002407-25cawzi0	45	21	produced	produce	VBN
cord-002407-25cawzi0	45	22	virions	virion	NNS
cord-002407-25cawzi0	45	23	from	from	IN
cord-002407-25cawzi0	45	24	infected	infected	JJ
cord-002407-25cawzi0	45	25	cells	cell	NNS
cord-002407-25cawzi0	45	26	[	[	-LRB-
cord-002407-25cawzi0	45	27	17	17	CD
cord-002407-25cawzi0	45	28	,	,	,
cord-002407-25cawzi0	45	29	18	18	CD
cord-002407-25cawzi0	45	30	]	]	-RRB-
cord-002407-25cawzi0	45	31	.	.	.
cord-002407-25cawzi0	46	1	IAVs	iav	NNS
cord-002407-25cawzi0	46	2	are	be	VBP
cord-002407-25cawzi0	46	3	classified	classify	VBN
cord-002407-25cawzi0	46	4	on	on	IN
cord-002407-25cawzi0	46	5	the	the	DT
cord-002407-25cawzi0	46	6	basis	basis	NN
cord-002407-25cawzi0	46	7	of	of	IN
cord-002407-25cawzi0	46	8	the	the	DT
cord-002407-25cawzi0	46	9	antigenic	antigenic	JJ
cord-002407-25cawzi0	46	10	properties	property	NNS
cord-002407-25cawzi0	46	11	of	of	IN
cord-002407-25cawzi0	46	12	HA	HA	NNP
cord-002407-25cawzi0	46	13	and	and	CC
cord-002407-25cawzi0	46	14	NA	NA	NNP
cord-002407-25cawzi0	46	15	into	into	IN
cord-002407-25cawzi0	46	16	18	18	CD
cord-002407-25cawzi0	46	17	HA	HA	NNP
cord-002407-25cawzi0	46	18	(	(	-LRB-
cord-002407-25cawzi0	46	19	H1-H18	H1-H18	NNP
cord-002407-25cawzi0	46	20	)	)	-RRB-
cord-002407-25cawzi0	46	21	and	and	CC
cord-002407-25cawzi0	46	22	11	11	CD
cord-002407-25cawzi0	46	23	NA	NA	NNP
cord-002407-25cawzi0	46	24	(	(	-LRB-
cord-002407-25cawzi0	46	25	N1-N11	N1-N11	NNP
cord-002407-25cawzi0	46	26	)	)	-RRB-
cord-002407-25cawzi0	46	27	subtypes	subtype	NNS
cord-002407-25cawzi0	46	28	[	[	-LRB-
cord-002407-25cawzi0	46	29	1	1	CD
cord-002407-25cawzi0	46	30	,	,	,
cord-002407-25cawzi0	46	31	19	19	CD
cord-002407-25cawzi0	46	32	,	,	,
cord-002407-25cawzi0	46	33	20	20	CD
cord-002407-25cawzi0	46	34	]	]	-RRB-
cord-002407-25cawzi0	46	35	.	.	.
cord-002407-25cawzi0	47	1	However	however	RB
cord-002407-25cawzi0	47	2	,	,	,
cord-002407-25cawzi0	47	3	only	only	RB
cord-002407-25cawzi0	47	4	IAV	IAV	NNP
cord-002407-25cawzi0	47	5	H1N1	H1N1	NNP
cord-002407-25cawzi0	47	6	and	and	CC
cord-002407-25cawzi0	47	7	H3N2	H3N2	NNP
cord-002407-25cawzi0	47	8	subtypes	subtype	NNS
cord-002407-25cawzi0	47	9	are	be	VBP
cord-002407-25cawzi0	47	10	currently	currently	RB
cord-002407-25cawzi0	47	11	circulating	circulate	VBG
cord-002407-25cawzi0	47	12	in	in	IN
cord-002407-25cawzi0	47	13	humans	human	NNS
cord-002407-25cawzi0	47	14	.	.	.
cord-002407-25cawzi0	48	1	On	on	IN
cord-002407-25cawzi0	48	2	the	the	DT
cord-002407-25cawzi0	48	3	other	other	JJ
cord-002407-25cawzi0	48	4	hand	hand	NN
cord-002407-25cawzi0	48	5	,	,	,
cord-002407-25cawzi0	48	6	two	two	CD
cord-002407-25cawzi0	48	7	major	major	JJ
cord-002407-25cawzi0	48	8	lineages	lineage	NNS
cord-002407-25cawzi0	48	9	of	of	IN
cord-002407-25cawzi0	48	10	IBV	IBV	NNP
cord-002407-25cawzi0	48	11	are	be	VBP
cord-002407-25cawzi0	48	12	circulating	circulate	VBG
cord-002407-25cawzi0	48	13	in	in	IN
cord-002407-25cawzi0	48	14	humans	human	NNS
cord-002407-25cawzi0	48	15	,	,	,
cord-002407-25cawzi0	48	16	the	the	DT
cord-002407-25cawzi0	48	17	Victoria	Victoria	NNP
cord-002407-25cawzi0	48	18	-	-	HYPH
cord-002407-25cawzi0	48	19	like	like	NNP
cord-002407-25cawzi0	48	20	and	and	CC
cord-002407-25cawzi0	48	21	Yamagata	Yamagata	NNP
cord-002407-25cawzi0	48	22	-	-	HYPH
cord-002407-25cawzi0	48	23	like	like	JJ
cord-002407-25cawzi0	48	24	subtypes	subtype	NNS
cord-002407-25cawzi0	48	25	that	that	WDT
cord-002407-25cawzi0	48	26	are	be	VBP
cord-002407-25cawzi0	48	27	divergent	divergent	JJ
cord-002407-25cawzi0	48	28	from	from	IN
cord-002407-25cawzi0	48	29	the	the	DT
cord-002407-25cawzi0	48	30	ancestral	ancestral	JJ
cord-002407-25cawzi0	48	31	IBV	IBV	NNP
cord-002407-25cawzi0	48	32	(	(	-LRB-
cord-002407-25cawzi0	48	33	B	b	NN
cord-002407-25cawzi0	48	34	/	/	SYM
cord-002407-25cawzi0	48	35	Lee/1940	lee/1940	NN
cord-002407-25cawzi0	48	36	)	)	-RRB-
cord-002407-25cawzi0	48	37	and	and	CC
cord-002407-25cawzi0	48	38	have	have	VBP
cord-002407-25cawzi0	48	39	been	be	VBN
cord-002407-25cawzi0	48	40	co	co	VBN
cord-002407-25cawzi0	48	41	-	-	NN
cord-002407-25cawzi0	48	42	circulating	circulate	VBG
cord-002407-25cawzi0	48	43	in	in	IN
cord-002407-25cawzi0	48	44	humans	human	NNS
cord-002407-25cawzi0	48	45	since	since	IN
cord-002407-25cawzi0	48	46	the	the	DT
cord-002407-25cawzi0	48	47	1980s	1980	NNS
cord-002407-25cawzi0	48	48	[	[	-LRB-
cord-002407-25cawzi0	48	49	5	5	CD
cord-002407-25cawzi0	48	50	,	,	,
cord-002407-25cawzi0	48	51	21	21	CD
cord-002407-25cawzi0	48	52	,	,	,
cord-002407-25cawzi0	48	53	22	22	CD
cord-002407-25cawzi0	48	54	]	]	-RRB-
cord-002407-25cawzi0	48	55	.	.	.
cord-002407-25cawzi0	49	1	These	these	DT
cord-002407-25cawzi0	49	2	two	two	CD
cord-002407-25cawzi0	49	3	subtypes	subtype	NNS
cord-002407-25cawzi0	49	4	are	be	VBP
cord-002407-25cawzi0	49	5	the	the	DT
cord-002407-25cawzi0	49	6	predominant	predominant	JJ
cord-002407-25cawzi0	49	7	circulating	circulate	VBG
cord-002407-25cawzi0	49	8	virus	virus	NN
cord-002407-25cawzi0	49	9	strains	strain	NNS
cord-002407-25cawzi0	49	10	about	about	IN
cord-002407-25cawzi0	49	11	once	once	RB
cord-002407-25cawzi0	49	12	every	every	DT
cord-002407-25cawzi0	49	13	three	three	CD
cord-002407-25cawzi0	49	14	years	year	NNS
cord-002407-25cawzi0	49	15	[	[	-LRB-
cord-002407-25cawzi0	49	16	23	23	CD
cord-002407-25cawzi0	49	17	]	]	-RRB-
cord-002407-25cawzi0	49	18	[	[	-LRB-
cord-002407-25cawzi0	49	19	24	24	CD
cord-002407-25cawzi0	49	20	]	]	-RRB-
cord-002407-25cawzi0	49	21	[	[	-LRB-
cord-002407-25cawzi0	49	22	25	25	CD
cord-002407-25cawzi0	49	23	]	]	-RRB-
cord-002407-25cawzi0	49	24	.	.	.
cord-002407-25cawzi0	50	1	Infection	infection	NN
cord-002407-25cawzi0	50	2	with	with	IN
cord-002407-25cawzi0	50	3	influenza	influenza	NN
cord-002407-25cawzi0	50	4	viruses	virus	NNS
cord-002407-25cawzi0	50	5	begins	begin	VBZ
cord-002407-25cawzi0	50	6	when	when	WRB
cord-002407-25cawzi0	50	7	the	the	DT
cord-002407-25cawzi0	50	8	viral	viral	JJ
cord-002407-25cawzi0	50	9	HA	HA	NNP
cord-002407-25cawzi0	50	10	protein	protein	NN
cord-002407-25cawzi0	50	11	binds	bind	VBZ
cord-002407-25cawzi0	50	12	to	to	IN
cord-002407-25cawzi0	50	13	its	-PRON-	PRP$
cord-002407-25cawzi0	50	14	cellular	cellular	JJ
cord-002407-25cawzi0	50	15	receptor	receptor	NN
cord-002407-25cawzi0	50	16	,	,	,
cord-002407-25cawzi0	50	17	a	a	DT
cord-002407-25cawzi0	50	18	sialylated	sialylated	JJ
cord-002407-25cawzi0	50	19	glycoprotein	glycoprotein	NN
cord-002407-25cawzi0	50	20	containing	contain	VBG
cord-002407-25cawzi0	50	21	α-2,3	α-2,3	NNP
cord-002407-25cawzi0	50	22	or	or	CC
cord-002407-25cawzi0	50	23	α-2,6	α-2,6	NN
cord-002407-25cawzi0	50	24	linkages	linkage	NNS
cord-002407-25cawzi0	50	25	[	[	-LRB-
cord-002407-25cawzi0	50	26	16	16	CD
cord-002407-25cawzi0	50	27	]	]	-RRB-
cord-002407-25cawzi0	50	28	.	.	.
cord-002407-25cawzi0	51	1	Upon	upon	IN
cord-002407-25cawzi0	51	2	the	the	DT
cord-002407-25cawzi0	51	3	binding	binding	NN
cord-002407-25cawzi0	51	4	to	to	IN
cord-002407-25cawzi0	51	5	the	the	DT
cord-002407-25cawzi0	51	6	receptor	receptor	NN
cord-002407-25cawzi0	51	7	,	,	,
cord-002407-25cawzi0	51	8	the	the	DT
cord-002407-25cawzi0	51	9	uptake	uptake	NN
cord-002407-25cawzi0	51	10	of	of	IN
cord-002407-25cawzi0	51	11	the	the	DT
cord-002407-25cawzi0	51	12	virus	virus	NN
cord-002407-25cawzi0	51	13	by	by	IN
cord-002407-25cawzi0	51	14	receptor	receptor	NN
cord-002407-25cawzi0	51	15	-	-	HYPH
cord-002407-25cawzi0	51	16	mediated	mediate	VBN
cord-002407-25cawzi0	51	17	endocytosis	endocytosis	NN
cord-002407-25cawzi0	51	18	is	be	VBZ
cord-002407-25cawzi0	51	19	initiated	initiate	VBN
cord-002407-25cawzi0	51	20	,	,	,
cord-002407-25cawzi0	51	21	and	and	CC
cord-002407-25cawzi0	51	22	the	the	DT
cord-002407-25cawzi0	51	23	cell	cell	NN
cord-002407-25cawzi0	51	24	membrane	membrane	NN
cord-002407-25cawzi0	51	25	engulfs	engulf	VBZ
cord-002407-25cawzi0	51	26	the	the	DT
cord-002407-25cawzi0	51	27	virus	virus	NN
cord-002407-25cawzi0	51	28	particles	particle	NNS
cord-002407-25cawzi0	51	29	in	in	IN
cord-002407-25cawzi0	51	30	an	an	DT
cord-002407-25cawzi0	51	31	endosome	endosome	NN
cord-002407-25cawzi0	51	32	.	.	.
cord-002407-25cawzi0	52	1	After	after	IN
cord-002407-25cawzi0	52	2	endocytosis	endocytosis	NN
cord-002407-25cawzi0	52	3	and	and	CC
cord-002407-25cawzi0	52	4	upon	upon	IN
cord-002407-25cawzi0	52	5	acidification	acidification	NN
cord-002407-25cawzi0	52	6	of	of	IN
cord-002407-25cawzi0	52	7	the	the	DT
cord-002407-25cawzi0	52	8	endosome	endosome	NN
cord-002407-25cawzi0	52	9	,	,	,
cord-002407-25cawzi0	52	10	influenza	influenza	NN
cord-002407-25cawzi0	52	11	viral	viral	JJ
cord-002407-25cawzi0	52	12	HA	HA	NNP
cord-002407-25cawzi0	52	13	undergoes	undergo	VBZ
cord-002407-25cawzi0	52	14	a	a	DT
cord-002407-25cawzi0	52	15	conformational	conformational	JJ
cord-002407-25cawzi0	52	16	change	change	NN
cord-002407-25cawzi0	52	17	responsible	responsible	JJ
cord-002407-25cawzi0	52	18	for	for	IN
cord-002407-25cawzi0	52	19	the	the	DT
cord-002407-25cawzi0	52	20	fusion	fusion	NN
cord-002407-25cawzi0	52	21	of	of	IN
cord-002407-25cawzi0	52	22	the	the	DT
cord-002407-25cawzi0	52	23	viral	viral	JJ
cord-002407-25cawzi0	52	24	and	and	CC
cord-002407-25cawzi0	52	25	the	the	DT
cord-002407-25cawzi0	52	26	endosome	endosome	NN
cord-002407-25cawzi0	52	27	membrane	membrane	NN
cord-002407-25cawzi0	52	28	[	[	-LRB-
cord-002407-25cawzi0	52	29	16	16	CD
cord-002407-25cawzi0	52	30	]	]	-RRB-
cord-002407-25cawzi0	52	31	.	.	.
cord-002407-25cawzi0	53	1	Then	then	RB
cord-002407-25cawzi0	53	2	,	,	,
cord-002407-25cawzi0	53	3	the	the	DT
cord-002407-25cawzi0	53	4	M2	M2	NNP
cord-002407-25cawzi0	53	5	(	(	-LRB-
cord-002407-25cawzi0	53	6	IAV	IAV	NNP
cord-002407-25cawzi0	53	7	)	)	-RRB-
cord-002407-25cawzi0	53	8	or	or	CC
cord-002407-25cawzi0	53	9	BM2	BM2	NNP
cord-002407-25cawzi0	53	10	(	(	-LRB-
cord-002407-25cawzi0	53	11	IBV	IBV	NNP
cord-002407-25cawzi0	53	12	)	)	-RRB-
cord-002407-25cawzi0	53	13	ion	ion	NN
cord-002407-25cawzi0	53	14	channel	channel	NN
cord-002407-25cawzi0	53	15	proteins	protein	NNS
cord-002407-25cawzi0	53	16	promote	promote	VBP
cord-002407-25cawzi0	53	17	the	the	DT
cord-002407-25cawzi0	53	18	release	release	NN
cord-002407-25cawzi0	53	19	of	of	IN
cord-002407-25cawzi0	53	20	the	the	DT
cord-002407-25cawzi0	53	21	vRNP	vrnp	NN
cord-002407-25cawzi0	53	22	complexes	complex	NNS
cord-002407-25cawzi0	53	23	from	from	IN
cord-002407-25cawzi0	53	24	the	the	DT
cord-002407-25cawzi0	53	25	virion	virion	NN
cord-002407-25cawzi0	53	26	core	core	NN
cord-002407-25cawzi0	53	27	into	into	IN
cord-002407-25cawzi0	53	28	the	the	DT
cord-002407-25cawzi0	53	29	cytoplasm	cytoplasm	NN
cord-002407-25cawzi0	53	30	of	of	IN
cord-002407-25cawzi0	53	31	infected	infected	JJ
cord-002407-25cawzi0	53	32	cells	cell	NNS
cord-002407-25cawzi0	53	33	[	[	-LRB-
cord-002407-25cawzi0	53	34	14	14	CD
cord-002407-25cawzi0	53	35	,	,	,
cord-002407-25cawzi0	53	36	26	26	CD
cord-002407-25cawzi0	53	37	]	]	-RRB-
cord-002407-25cawzi0	53	38	.	.	.
cord-002407-25cawzi0	54	1	The	the	DT
cord-002407-25cawzi0	54	2	vRNPs	vrnp	NNS
cord-002407-25cawzi0	54	3	are	be	VBP
cord-002407-25cawzi0	54	4	translocated	translocate	VBN
cord-002407-25cawzi0	54	5	from	from	IN
cord-002407-25cawzi0	54	6	the	the	DT
cord-002407-25cawzi0	54	7	cytoplasm	cytoplasm	NN
cord-002407-25cawzi0	54	8	to	to	IN
cord-002407-25cawzi0	54	9	the	the	DT
cord-002407-25cawzi0	54	10	nucleus	nucleus	NN
cord-002407-25cawzi0	54	11	of	of	IN
cord-002407-25cawzi0	54	12	infected	infected	JJ
cord-002407-25cawzi0	54	13	cells	cell	NNS
cord-002407-25cawzi0	54	14	to	to	TO
cord-002407-25cawzi0	54	15	initiate	initiate	VB
cord-002407-25cawzi0	54	16	viral	viral	JJ
cord-002407-25cawzi0	54	17	genome	genome	NN
cord-002407-25cawzi0	54	18	replication	replication	NN
cord-002407-25cawzi0	54	19	and	and	CC
cord-002407-25cawzi0	54	20	gene	gene	NN
cord-002407-25cawzi0	54	21	transcription	transcription	NN
cord-002407-25cawzi0	54	22	[	[	-LRB-
cord-002407-25cawzi0	54	23	27	27	CD
cord-002407-25cawzi0	54	24	]	]	-RRB-
cord-002407-25cawzi0	54	25	.	.	.
cord-002407-25cawzi0	55	1	The	the	DT
cord-002407-25cawzi0	55	2	nuclear	nuclear	JJ
cord-002407-25cawzi0	55	3	export	export	NN
cord-002407-25cawzi0	55	4	(	(	-LRB-
cord-002407-25cawzi0	55	5	NEP	NEP	NNP
cord-002407-25cawzi0	55	6	)	)	-RRB-
cord-002407-25cawzi0	55	7	and	and	CC
cord-002407-25cawzi0	55	8	matrix	matrix	NN
cord-002407-25cawzi0	55	9	1	1	CD
cord-002407-25cawzi0	55	10	(	(	-LRB-
cord-002407-25cawzi0	55	11	M1	M1	NNP
cord-002407-25cawzi0	55	12	)	)	-RRB-
cord-002407-25cawzi0	55	13	proteins	protein	NNS
cord-002407-25cawzi0	55	14	are	be	VBP
cord-002407-25cawzi0	55	15	responsible	responsible	JJ
cord-002407-25cawzi0	55	16	for	for	IN
cord-002407-25cawzi0	55	17	the	the	DT
cord-002407-25cawzi0	55	18	nuclear	nuclear	JJ
cord-002407-25cawzi0	55	19	export	export	NN
cord-002407-25cawzi0	55	20	of	of	IN
cord-002407-25cawzi0	55	21	newly	newly	RB
cord-002407-25cawzi0	55	22	-	-	HYPH
cord-002407-25cawzi0	55	23	synthesized	synthesize	VBN
cord-002407-25cawzi0	55	24	vRNPs	vrnps	RB
cord-002407-25cawzi0	55	25	into	into	IN
cord-002407-25cawzi0	55	26	the	the	DT
cord-002407-25cawzi0	55	27	cytoplasm	cytoplasm	NN
cord-002407-25cawzi0	55	28	of	of	IN
cord-002407-25cawzi0	55	29	infected	infected	JJ
cord-002407-25cawzi0	55	30	cells	cell	NNS
cord-002407-25cawzi0	55	31	.	.	.
cord-002407-25cawzi0	56	1	Notably	notably	RB
cord-002407-25cawzi0	56	2	,	,	,
cord-002407-25cawzi0	56	3	a	a	DT
cord-002407-25cawzi0	56	4	single	single	JJ
cord-002407-25cawzi0	56	5	copy	copy	NN
cord-002407-25cawzi0	56	6	of	of	IN
cord-002407-25cawzi0	56	7	each	each	DT
cord-002407-25cawzi0	56	8	of	of	IN
cord-002407-25cawzi0	56	9	the	the	DT
cord-002407-25cawzi0	56	10	eight	eight	CD
cord-002407-25cawzi0	56	11	vRNAs	vrna	NNS
cord-002407-25cawzi0	56	12	is	be	VBZ
cord-002407-25cawzi0	56	13	packaged	package	VBN
cord-002407-25cawzi0	56	14	into	into	IN
cord-002407-25cawzi0	56	15	new	new	JJ
cord-002407-25cawzi0	56	16	virions	virion	NNS
cord-002407-25cawzi0	56	17	[	[	-LRB-
cord-002407-25cawzi0	56	18	28	28	CD
cord-002407-25cawzi0	56	19	,	,	,
cord-002407-25cawzi0	56	20	29	29	CD
cord-002407-25cawzi0	56	21	]	]	-RRB-
cord-002407-25cawzi0	56	22	.	.	.
cord-002407-25cawzi0	57	1	Selective	selective	JJ
cord-002407-25cawzi0	57	2	package	package	NN
cord-002407-25cawzi0	57	3	of	of	IN
cord-002407-25cawzi0	57	4	influenza	influenza	NN
cord-002407-25cawzi0	57	5	vRNAs	vrna	NNS
cord-002407-25cawzi0	57	6	into	into	IN
cord-002407-25cawzi0	57	7	nascent	nascent	JJ
cord-002407-25cawzi0	57	8	virions	virion	NNS
cord-002407-25cawzi0	57	9	is	be	VBZ
cord-002407-25cawzi0	57	10	mediated	mediate	VBN
cord-002407-25cawzi0	57	11	by	by	IN
cord-002407-25cawzi0	57	12	RNA	RNA	NNP
cord-002407-25cawzi0	57	13	-	-	HYPH
cord-002407-25cawzi0	57	14	RNA	RNA	NNP
cord-002407-25cawzi0	57	15	interactions	interaction	NNS
cord-002407-25cawzi0	57	16	of	of	IN
cord-002407-25cawzi0	57	17	vRNA	vrna	JJ
cord-002407-25cawzi0	57	18	packaging	packaging	NN
cord-002407-25cawzi0	57	19	signals	signal	NNS
cord-002407-25cawzi0	57	20	present	present	JJ
cord-002407-25cawzi0	57	21	at	at	IN
cord-002407-25cawzi0	57	22	the	the	DT
cord-002407-25cawzi0	57	23	terminal	terminal	NN
cord-002407-25cawzi0	57	24	ends	end	NNS
cord-002407-25cawzi0	57	25	of	of	IN
cord-002407-25cawzi0	57	26	each	each	DT
cord-002407-25cawzi0	57	27	of	of	IN
cord-002407-25cawzi0	57	28	the	the	DT
cord-002407-25cawzi0	57	29	vRNA	vrna	JJ
cord-002407-25cawzi0	57	30	segments	segment	NNS
cord-002407-25cawzi0	57	31	[	[	-LRB-
cord-002407-25cawzi0	57	32	30	30	CD
cord-002407-25cawzi0	57	33	]	]	-RRB-
cord-002407-25cawzi0	57	34	.	.	.
cord-002407-25cawzi0	58	1	Finally	finally	RB
cord-002407-25cawzi0	58	2	,	,	,
cord-002407-25cawzi0	58	3	the	the	DT
cord-002407-25cawzi0	58	4	receptor	receptor	NN
cord-002407-25cawzi0	58	5	-	-	HYPH
cord-002407-25cawzi0	58	6	destroying	destroy	VBG
cord-002407-25cawzi0	58	7	enzymatic	enzymatic	JJ
cord-002407-25cawzi0	58	8	activity	activity	NN
cord-002407-25cawzi0	58	9	of	of	IN
cord-002407-25cawzi0	58	10	NA	NA	NNP
cord-002407-25cawzi0	58	11	is	be	VBZ
cord-002407-25cawzi0	58	12	responsible	responsible	JJ
cord-002407-25cawzi0	58	13	for	for	IN
cord-002407-25cawzi0	58	14	the	the	DT
cord-002407-25cawzi0	58	15	release	release	NN
cord-002407-25cawzi0	58	16	of	of	IN
cord-002407-25cawzi0	58	17	newly	newly	RB
cord-002407-25cawzi0	58	18	-	-	HYPH
cord-002407-25cawzi0	58	19	synthesized	synthesize	VBN
cord-002407-25cawzi0	58	20	viral	viral	JJ
cord-002407-25cawzi0	58	21	particles	particle	NNS
cord-002407-25cawzi0	58	22	from	from	IN
cord-002407-25cawzi0	58	23	the	the	DT
cord-002407-25cawzi0	58	24	surface	surface	NN
cord-002407-25cawzi0	58	25	of	of	IN
cord-002407-25cawzi0	58	26	infected	infected	JJ
cord-002407-25cawzi0	58	27	cells	cell	NNS
cord-002407-25cawzi0	58	28	[	[	-LRB-
cord-002407-25cawzi0	58	29	17	17	CD
cord-002407-25cawzi0	58	30	]	]	-RRB-
cord-002407-25cawzi0	58	31	.	.	.
cord-002407-25cawzi0	59	1	Among	among	IN
cord-002407-25cawzi0	59	2	the	the	DT
cord-002407-25cawzi0	59	3	first	first	JJ
cord-002407-25cawzi0	59	4	battles	battle	NNS
cord-002407-25cawzi0	59	5	between	between	IN
cord-002407-25cawzi0	59	6	the	the	DT
cord-002407-25cawzi0	59	7	host	host	NN
cord-002407-25cawzi0	59	8	and	and	CC
cord-002407-25cawzi0	59	9	the	the	DT
cord-002407-25cawzi0	59	10	virus	virus	NN
cord-002407-25cawzi0	59	11	,	,	,
cord-002407-25cawzi0	59	12	cellular	cellular	JJ
cord-002407-25cawzi0	59	13	type	type	NN
cord-002407-25cawzi0	60	1	I	-PRON-	PRP
cord-002407-25cawzi0	61	1	interferon	interferon	NNP
cord-002407-25cawzi0	61	2	(	(	-LRB-
cord-002407-25cawzi0	61	3	IFN	IFN	NNP
cord-002407-25cawzi0	61	4	-	-	HYPH
cord-002407-25cawzi0	61	5	I	I	NNP
cord-002407-25cawzi0	61	6	)	)	-RRB-
cord-002407-25cawzi0	61	7	plays	play	VBZ
cord-002407-25cawzi0	61	8	an	an	DT
cord-002407-25cawzi0	61	9	important	important	JJ
cord-002407-25cawzi0	61	10	role	role	NN
cord-002407-25cawzi0	61	11	in	in	IN
cord-002407-25cawzi0	61	12	controlling	control	VBG
cord-002407-25cawzi0	61	13	viral	viral	JJ
cord-002407-25cawzi0	61	14	infection	infection	NN
cord-002407-25cawzi0	61	15	[	[	-LRB-
cord-002407-25cawzi0	61	16	31	31	CD
cord-002407-25cawzi0	61	17	]	]	-RRB-
cord-002407-25cawzi0	61	18	.	.	.
cord-002407-25cawzi0	62	1	Therefore	therefore	RB
cord-002407-25cawzi0	62	2	,	,	,
cord-002407-25cawzi0	62	3	viruses	virus	NNS
cord-002407-25cawzi0	62	4	have	have	VBP
cord-002407-25cawzi0	62	5	developed	develop	VBN
cord-002407-25cawzi0	62	6	multiple	multiple	JJ
cord-002407-25cawzi0	62	7	strategies	strategy	NNS
cord-002407-25cawzi0	62	8	to	to	TO
cord-002407-25cawzi0	62	9	hijack	hijack	VB
cord-002407-25cawzi0	62	10	the	the	DT
cord-002407-25cawzi0	62	11	host	host	NN
cord-002407-25cawzi0	62	12	cellular	cellular	JJ
cord-002407-25cawzi0	62	13	immune	immune	JJ
cord-002407-25cawzi0	62	14	response	response	NN
cord-002407-25cawzi0	62	15	.	.	.
cord-002407-25cawzi0	63	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	63	2	vRNA	vrna	IN
cord-002407-25cawzi0	63	3	segment	segment	NN
cord-002407-25cawzi0	63	4	8	8	CD
cord-002407-25cawzi0	63	5	,	,	,
cord-002407-25cawzi0	63	6	or	or	CC
cord-002407-25cawzi0	63	7	the	the	DT
cord-002407-25cawzi0	63	8	nonstructural	nonstructural	JJ
cord-002407-25cawzi0	63	9	(	(	-LRB-
cord-002407-25cawzi0	63	10	NS	NS	NNP
cord-002407-25cawzi0	63	11	)	)	-RRB-
cord-002407-25cawzi0	63	12	gene	gene	NN
cord-002407-25cawzi0	63	13	,	,	,
cord-002407-25cawzi0	63	14	encodes	encode	VBZ
cord-002407-25cawzi0	63	15	two	two	CD
cord-002407-25cawzi0	63	16	distinct	distinct	JJ
cord-002407-25cawzi0	63	17	proteins	protein	NNS
cord-002407-25cawzi0	63	18	through	through	IN
cord-002407-25cawzi0	63	19	a	a	DT
cord-002407-25cawzi0	63	20	direct	direct	JJ
cord-002407-25cawzi0	63	21	or	or	CC
cord-002407-25cawzi0	63	22	alternative	alternative	JJ
cord-002407-25cawzi0	63	23	splicing	splicing	NN
cord-002407-25cawzi0	63	24	mechanism	mechanism	NN
cord-002407-25cawzi0	63	25	[	[	-LRB-
cord-002407-25cawzi0	63	26	1	1	CD
cord-002407-25cawzi0	63	27	]	]	-RRB-
cord-002407-25cawzi0	63	28	.	.	.
cord-002407-25cawzi0	64	1	Influenza	influenza	NN
cord-002407-25cawzi0	64	2	virus	virus	NN
cord-002407-25cawzi0	64	3	segment	segment	NN
cord-002407-25cawzi0	64	4	8	8	CD
cord-002407-25cawzi0	64	5	produces	produce	VBZ
cord-002407-25cawzi0	64	6	the	the	DT
cord-002407-25cawzi0	64	7	nonstructural	nonstructural	JJ
cord-002407-25cawzi0	64	8	protein	protein	NN
cord-002407-25cawzi0	64	9	1	1	CD
cord-002407-25cawzi0	64	10	(	(	-LRB-
cord-002407-25cawzi0	64	11	NS1	ns1	UH
cord-002407-25cawzi0	64	12	)	)	-RRB-
cord-002407-25cawzi0	64	13	as	as	IN
cord-002407-25cawzi0	64	14	a	a	DT
cord-002407-25cawzi0	64	15	primary	primary	JJ
cord-002407-25cawzi0	64	16	transcript	transcript	NN
cord-002407-25cawzi0	64	17	,	,	,
cord-002407-25cawzi0	64	18	whereas	whereas	IN
cord-002407-25cawzi0	64	19	NEP	NEP	NNP
cord-002407-25cawzi0	64	20	is	be	VBZ
cord-002407-25cawzi0	64	21	produced	produce	VBN
cord-002407-25cawzi0	64	22	by	by	IN
cord-002407-25cawzi0	64	23	alternative	alternative	JJ
cord-002407-25cawzi0	64	24	splicing	splicing	NN
cord-002407-25cawzi0	64	25	of	of	IN
cord-002407-25cawzi0	64	26	the	the	DT
cord-002407-25cawzi0	64	27	NS	NS	NNP
cord-002407-25cawzi0	65	1	mRNA	mRNA	NNP
cord-002407-25cawzi0	65	2	[	[	-LRB-
cord-002407-25cawzi0	65	3	32	32	CD
cord-002407-25cawzi0	65	4	]	]	-RRB-
cord-002407-25cawzi0	65	5	.	.	.
cord-002407-25cawzi0	66	1	NS1	NS1	NNS
cord-002407-25cawzi0	66	2	has	have	VBZ
cord-002407-25cawzi0	66	3	multiple	multiple	JJ
cord-002407-25cawzi0	66	4	functions	function	NNS
cord-002407-25cawzi0	66	5	during	during	IN
cord-002407-25cawzi0	66	6	the	the	DT
cord-002407-25cawzi0	66	7	replication	replication	NN
cord-002407-25cawzi0	66	8	cycle	cycle	NN
cord-002407-25cawzi0	66	9	of	of	IN
cord-002407-25cawzi0	66	10	influenza	influenza	NN
cord-002407-25cawzi0	66	11	virus	virus	NN
cord-002407-25cawzi0	66	12	,	,	,
cord-002407-25cawzi0	66	13	but	but	CC
cord-002407-25cawzi0	66	14	most	most	JJS
cord-002407-25cawzi0	66	15	notably	notably	RB
cord-002407-25cawzi0	66	16	inhibits	inhibit	VBZ
cord-002407-25cawzi0	66	17	induction	induction	NN
cord-002407-25cawzi0	66	18	of	of	IN
cord-002407-25cawzi0	66	19	IFN	IFN	NNP
cord-002407-25cawzi0	66	20	-	-	HYPH
cord-002407-25cawzi0	66	21	I	-PRON-	PRP
cord-002407-25cawzi0	66	22	response	response	NN
cord-002407-25cawzi0	66	23	and	and	CC
cord-002407-25cawzi0	66	24	innate	innate	JJ
cord-002407-25cawzi0	66	25	immune	immune	JJ
cord-002407-25cawzi0	66	26	activation	activation	NN
cord-002407-25cawzi0	66	27	[	[	-LRB-
cord-002407-25cawzi0	66	28	31	31	CD
cord-002407-25cawzi0	66	29	]	]	-RRB-
cord-002407-25cawzi0	66	30	.	.	.
cord-002407-25cawzi0	67	1	Influenza	influenza	NN
cord-002407-25cawzi0	67	2	viruses	virus	NNS
cord-002407-25cawzi0	67	3	pose	pose	VBP
cord-002407-25cawzi0	67	4	a	a	DT
cord-002407-25cawzi0	67	5	threat	threat	NN
cord-002407-25cawzi0	67	6	to	to	IN
cord-002407-25cawzi0	67	7	human	human	JJ
cord-002407-25cawzi0	67	8	health	health	NN
cord-002407-25cawzi0	67	9	and	and	CC
cord-002407-25cawzi0	67	10	are	be	VBP
cord-002407-25cawzi0	67	11	responsible	responsible	JJ
cord-002407-25cawzi0	67	12	for	for	IN
cord-002407-25cawzi0	67	13	global	global	JJ
cord-002407-25cawzi0	67	14	epidemics	epidemic	NNS
cord-002407-25cawzi0	67	15	every	every	DT
cord-002407-25cawzi0	67	16	year	year	NN
cord-002407-25cawzi0	67	17	[	[	-LRB-
cord-002407-25cawzi0	67	18	33	33	CD
cord-002407-25cawzi0	67	19	]	]	-RRB-
cord-002407-25cawzi0	68	1	[	[	-LRB-
cord-002407-25cawzi0	68	2	34	34	CD
cord-002407-25cawzi0	68	3	]	]	-RRB-
cord-002407-25cawzi0	68	4	[	[	-LRB-
cord-002407-25cawzi0	68	5	35	35	CD
cord-002407-25cawzi0	68	6	]	]	-RRB-
cord-002407-25cawzi0	68	7	[	[	-LRB-
cord-002407-25cawzi0	68	8	36	36	CD
cord-002407-25cawzi0	68	9	]	]	-RRB-
cord-002407-25cawzi0	68	10	[	[	-LRB-
cord-002407-25cawzi0	68	11	37	37	CD
cord-002407-25cawzi0	68	12	]	]	-RRB-
cord-002407-25cawzi0	68	13	.	.	.
cord-002407-25cawzi0	69	1	In	in	IN
cord-002407-25cawzi0	69	2	fact	fact	NN
cord-002407-25cawzi0	69	3	,	,	,
cord-002407-25cawzi0	69	4	influenza	influenza	NN
cord-002407-25cawzi0	69	5	virus	virus	NN
cord-002407-25cawzi0	69	6	is	be	VBZ
cord-002407-25cawzi0	69	7	one	one	CD
cord-002407-25cawzi0	69	8	of	of	IN
cord-002407-25cawzi0	69	9	the	the	DT
cord-002407-25cawzi0	69	10	most	most	RBS
cord-002407-25cawzi0	69	11	significant	significant	JJ
cord-002407-25cawzi0	69	12	causes	cause	NNS
cord-002407-25cawzi0	69	13	of	of	IN
cord-002407-25cawzi0	69	14	morbidity	morbidity	NN
cord-002407-25cawzi0	69	15	and	and	CC
cord-002407-25cawzi0	69	16	mortality	mortality	NN
cord-002407-25cawzi0	69	17	yearly	yearly	JJ
cord-002407-25cawzi0	69	18	,	,	,
cord-002407-25cawzi0	69	19	leading	lead	VBG
cord-002407-25cawzi0	69	20	to	to	IN
cord-002407-25cawzi0	69	21	a	a	DT
cord-002407-25cawzi0	69	22	significant	significant	JJ
cord-002407-25cawzi0	69	23	economic	economic	JJ
cord-002407-25cawzi0	69	24	impact	impact	NN
cord-002407-25cawzi0	69	25	[	[	-LRB-
cord-002407-25cawzi0	69	26	38	38	CD
cord-002407-25cawzi0	69	27	]	]	-RRB-
cord-002407-25cawzi0	69	28	.	.	.
cord-002407-25cawzi0	70	1	Despite	despite	IN
cord-002407-25cawzi0	70	2	the	the	DT
cord-002407-25cawzi0	70	3	implementation	implementation	NN
cord-002407-25cawzi0	70	4	of	of	IN
cord-002407-25cawzi0	70	5	effective	effective	JJ
cord-002407-25cawzi0	70	6	and	and	CC
cord-002407-25cawzi0	70	7	comprehensive	comprehensive	JJ
cord-002407-25cawzi0	70	8	vaccination	vaccination	NN
cord-002407-25cawzi0	70	9	programs	program	NNS
cord-002407-25cawzi0	70	10	,	,	,
cord-002407-25cawzi0	70	11	the	the	DT
cord-002407-25cawzi0	70	12	World	World	NNP
cord-002407-25cawzi0	70	13	Health	Health	NNP
cord-002407-25cawzi0	70	14	Organization	Organization	NNP
cord-002407-25cawzi0	70	15	(	(	-LRB-
cord-002407-25cawzi0	70	16	WHO	who	WP
cord-002407-25cawzi0	70	17	)	)	-RRB-
cord-002407-25cawzi0	70	18	estimates	estimate	VBZ
cord-002407-25cawzi0	70	19	that	that	IN
cord-002407-25cawzi0	70	20	seasonal	seasonal	JJ
cord-002407-25cawzi0	70	21	influenza	influenza	NN
cord-002407-25cawzi0	70	22	virus	virus	NN
cord-002407-25cawzi0	70	23	infections	infection	NNS
cord-002407-25cawzi0	70	24	results	result	VBZ
cord-002407-25cawzi0	70	25	in	in	IN
cord-002407-25cawzi0	70	26	about	about	RB
cord-002407-25cawzi0	70	27	one	one	CD
cord-002407-25cawzi0	70	28	billion	billion	CD
cord-002407-25cawzi0	70	29	infections	infection	NNS
cord-002407-25cawzi0	70	30	,	,	,
cord-002407-25cawzi0	70	31	3	3	CD
cord-002407-25cawzi0	70	32	-	-	SYM
cord-002407-25cawzi0	70	33	5	5	CD
cord-002407-25cawzi0	70	34	million	million	CD
cord-002407-25cawzi0	70	35	cases	case	NNS
cord-002407-25cawzi0	70	36	of	of	IN
cord-002407-25cawzi0	70	37	severe	severe	JJ
cord-002407-25cawzi0	70	38	disease	disease	NN
cord-002407-25cawzi0	70	39	and	and	CC
cord-002407-25cawzi0	70	40	between	between	IN
cord-002407-25cawzi0	70	41	300,000	300,000	CD
cord-002407-25cawzi0	70	42	and	and	CC
cord-002407-25cawzi0	70	43	500,000	500,000	CD
cord-002407-25cawzi0	70	44	deaths	death	NNS
cord-002407-25cawzi0	70	45	around	around	IN
cord-002407-25cawzi0	70	46	the	the	DT
cord-002407-25cawzi0	70	47	world	world	NN
cord-002407-25cawzi0	70	48	annually	annually	RB
cord-002407-25cawzi0	70	49	[	[	-LRB-
cord-002407-25cawzi0	70	50	39	39	CD
cord-002407-25cawzi0	70	51	]	]	-RRB-
cord-002407-25cawzi0	70	52	.	.	.
cord-002407-25cawzi0	71	1	Moreover	moreover	RB
cord-002407-25cawzi0	71	2	,	,	,
cord-002407-25cawzi0	71	3	just	just	RB
cord-002407-25cawzi0	71	4	in	in	IN
cord-002407-25cawzi0	71	5	the	the	DT
cord-002407-25cawzi0	71	6	United	United	NNP
cord-002407-25cawzi0	71	7	States	States	NNP
cord-002407-25cawzi0	71	8	(	(	-LRB-
cord-002407-25cawzi0	71	9	U.S.	U.S.	NNP
cord-002407-25cawzi0	71	10	)	)	-RRB-
cord-002407-25cawzi0	71	11	,	,	,
cord-002407-25cawzi0	71	12	influenza	influenza	NN
cord-002407-25cawzi0	71	13	viral	viral	JJ
cord-002407-25cawzi0	71	14	infections	infection	NNS
cord-002407-25cawzi0	71	15	result	result	VBP
cord-002407-25cawzi0	71	16	in	in	IN
cord-002407-25cawzi0	71	17	an	an	DT
cord-002407-25cawzi0	71	18	average	average	NN
cord-002407-25cawzi0	71	19	of	of	IN
cord-002407-25cawzi0	71	20	87	87	CD
cord-002407-25cawzi0	71	21	billion	billion	CD
cord-002407-25cawzi0	71	22	dollars	dollar	NNS
cord-002407-25cawzi0	71	23	of	of	IN
cord-002407-25cawzi0	71	24	cost	cost	NN
cord-002407-25cawzi0	71	25	due	due	IN
cord-002407-25cawzi0	71	26	to	to	IN
cord-002407-25cawzi0	71	27	prophylactic	prophylactic	JJ
cord-002407-25cawzi0	71	28	,	,	,
cord-002407-25cawzi0	71	29	therapeutic	therapeutic	JJ
cord-002407-25cawzi0	71	30	and	and	CC
cord-002407-25cawzi0	71	31	hospitalization	hospitalization	NN
cord-002407-25cawzi0	71	32	costs	cost	NNS
cord-002407-25cawzi0	71	33	,	,	,
cord-002407-25cawzi0	71	34	as	as	RB
cord-002407-25cawzi0	71	35	well	well	RB
cord-002407-25cawzi0	71	36	as	as	IN
cord-002407-25cawzi0	71	37	missed	miss	VBN
cord-002407-25cawzi0	71	38	school	school	NN
cord-002407-25cawzi0	71	39	or	or	CC
cord-002407-25cawzi0	71	40	work	work	NN
cord-002407-25cawzi0	71	41	days	day	NNS
cord-002407-25cawzi0	71	42	[	[	-LRB-
cord-002407-25cawzi0	71	43	38	38	CD
cord-002407-25cawzi0	71	44	,	,	,
cord-002407-25cawzi0	71	45	[	[	-LRB-
cord-002407-25cawzi0	71	46	40	40	CD
cord-002407-25cawzi0	71	47	]	]	-RRB-
cord-002407-25cawzi0	71	48	[	[	-LRB-
cord-002407-25cawzi0	71	49	41	41	CD
cord-002407-25cawzi0	71	50	]	]	-RRB-
cord-002407-25cawzi0	71	51	[	[	-LRB-
cord-002407-25cawzi0	71	52	42	42	CD
cord-002407-25cawzi0	71	53	]	]	-RRB-
cord-002407-25cawzi0	71	54	.	.	.
cord-002407-25cawzi0	72	1	In	in	IN
cord-002407-25cawzi0	72	2	addition	addition	NN
cord-002407-25cawzi0	72	3	to	to	IN
cord-002407-25cawzi0	72	4	seasonal	seasonal	JJ
cord-002407-25cawzi0	72	5	influenza	influenza	NN
cord-002407-25cawzi0	72	6	,	,	,
cord-002407-25cawzi0	72	7	IAV	IAV	NNP
cord-002407-25cawzi0	72	8	can	can	MD
cord-002407-25cawzi0	72	9	cause	cause	VB
cord-002407-25cawzi0	72	10	sporadic	sporadic	JJ
cord-002407-25cawzi0	72	11	pandemics	pandemic	NNS
cord-002407-25cawzi0	72	12	of	of	IN
cord-002407-25cawzi0	72	13	great	great	JJ
cord-002407-25cawzi0	72	14	consequences	consequence	NNS
cord-002407-25cawzi0	72	15	when	when	WRB
cord-002407-25cawzi0	72	16	novel	novel	NN
cord-002407-25cawzi0	72	17	viruses	virus	NNS
cord-002407-25cawzi0	72	18	are	be	VBP
cord-002407-25cawzi0	72	19	introduced	introduce	VBN
cord-002407-25cawzi0	72	20	into	into	IN
cord-002407-25cawzi0	72	21	humans	human	NNS
cord-002407-25cawzi0	72	22	[	[	-LRB-
cord-002407-25cawzi0	72	23	43	43	CD
cord-002407-25cawzi0	72	24	]	]	-RRB-
cord-002407-25cawzi0	72	25	.	.	.
cord-002407-25cawzi0	73	1	The	the	DT
cord-002407-25cawzi0	73	2	mechanisms	mechanism	NNS
cord-002407-25cawzi0	73	3	responsible	responsible	JJ
cord-002407-25cawzi0	73	4	for	for	IN
cord-002407-25cawzi0	73	5	the	the	DT
cord-002407-25cawzi0	73	6	emergence	emergence	NN
cord-002407-25cawzi0	73	7	of	of	IN
cord-002407-25cawzi0	73	8	seasonal	seasonal	JJ
cord-002407-25cawzi0	73	9	and	and	CC
cord-002407-25cawzi0	73	10	pandemic	pandemic	NN
cord-002407-25cawzi0	73	11	IAVs	iav	NNS
cord-002407-25cawzi0	73	12	are	be	VBP
cord-002407-25cawzi0	73	13	antigenic	antigenic	JJ
cord-002407-25cawzi0	73	14	drift	drift	NN
cord-002407-25cawzi0	73	15	and	and	CC
cord-002407-25cawzi0	73	16	antigenic	antigenic	JJ
cord-002407-25cawzi0	73	17	shift	shift	NN
cord-002407-25cawzi0	73	18	,	,	,
cord-002407-25cawzi0	73	19	respectively	respectively	RB
cord-002407-25cawzi0	73	20	[	[	-LRB-
cord-002407-25cawzi0	73	21	12	12	CD
cord-002407-25cawzi0	73	22	,	,	,
cord-002407-25cawzi0	73	23	[	[	-LRB-
cord-002407-25cawzi0	73	24	44	44	CD
cord-002407-25cawzi0	73	25	]	]	-RRB-
cord-002407-25cawzi0	73	26	[	[	-LRB-
cord-002407-25cawzi0	73	27	45	45	CD
cord-002407-25cawzi0	73	28	]	]	-RRB-
cord-002407-25cawzi0	73	29	[	[	-LRB-
cord-002407-25cawzi0	73	30	46	46	CD
cord-002407-25cawzi0	73	31	]	]	-RRB-
cord-002407-25cawzi0	73	32	.	.	.
cord-002407-25cawzi0	74	1	In	in	IN
cord-002407-25cawzi0	74	2	the	the	DT
cord-002407-25cawzi0	74	3	case	case	NN
cord-002407-25cawzi0	74	4	of	of	IN
cord-002407-25cawzi0	74	5	seasonal	seasonal	JJ
cord-002407-25cawzi0	74	6	influenza	influenza	NN
cord-002407-25cawzi0	74	7	,	,	,
cord-002407-25cawzi0	74	8	mutations	mutation	NNS
cord-002407-25cawzi0	74	9	in	in	IN
cord-002407-25cawzi0	74	10	the	the	DT
cord-002407-25cawzi0	74	11	viral	viral	JJ
cord-002407-25cawzi0	74	12	genome	genome	NN
cord-002407-25cawzi0	74	13	result	result	NN
cord-002407-25cawzi0	74	14	in	in	IN
cord-002407-25cawzi0	74	15	the	the	DT
cord-002407-25cawzi0	74	16	selection	selection	NN
cord-002407-25cawzi0	74	17	of	of	IN
cord-002407-25cawzi0	74	18	antigenic	antigenic	JJ
cord-002407-25cawzi0	74	19	variants	variant	NNS
cord-002407-25cawzi0	74	20	with	with	IN
cord-002407-25cawzi0	74	21	changes	change	NNS
cord-002407-25cawzi0	74	22	in	in	IN
cord-002407-25cawzi0	74	23	viral	viral	JJ
cord-002407-25cawzi0	74	24	tropism	tropism	NN
cord-002407-25cawzi0	74	25	,	,	,
cord-002407-25cawzi0	74	26	increased	increase	VBN
cord-002407-25cawzi0	74	27	levels	level	NNS
cord-002407-25cawzi0	74	28	of	of	IN
cord-002407-25cawzi0	74	29	viral	viral	JJ
cord-002407-25cawzi0	74	30	fitness	fitness	NN
cord-002407-25cawzi0	74	31	or	or	CC
cord-002407-25cawzi0	74	32	in	in	IN
cord-002407-25cawzi0	74	33	the	the	DT
cord-002407-25cawzi0	74	34	ability	ability	NN
cord-002407-25cawzi0	74	35	to	to	TO
cord-002407-25cawzi0	74	36	escape	escape	VB
cord-002407-25cawzi0	74	37	neutralizing	neutralize	VBG
cord-002407-25cawzi0	74	38	antibody	antibody	NN
cord-002407-25cawzi0	74	39	(	(	-LRB-
cord-002407-25cawzi0	74	40	NAb	NAb	NNS
cord-002407-25cawzi0	74	41	)	)	-RRB-
cord-002407-25cawzi0	74	42	responses	response	NNS
cord-002407-25cawzi0	74	43	induced	induce	VBN
cord-002407-25cawzi0	74	44	upon	upon	IN
cord-002407-25cawzi0	74	45	previous	previous	JJ
cord-002407-25cawzi0	74	46	natural	natural	JJ
cord-002407-25cawzi0	74	47	infections	infection	NNS
cord-002407-25cawzi0	74	48	or	or	CC
cord-002407-25cawzi0	74	49	vaccinations	vaccination	NNS
cord-002407-25cawzi0	74	50	[	[	-LRB-
cord-002407-25cawzi0	74	51	44	44	CD
cord-002407-25cawzi0	74	52	,	,	,
cord-002407-25cawzi0	74	53	45	45	CD
cord-002407-25cawzi0	74	54	]	]	-RRB-
cord-002407-25cawzi0	74	55	.	.	.
cord-002407-25cawzi0	75	1	Moreover	moreover	RB
cord-002407-25cawzi0	75	2	,	,	,
cord-002407-25cawzi0	75	3	antigenic	antigenic	JJ
cord-002407-25cawzi0	75	4	drift	drift	NN
cord-002407-25cawzi0	75	5	can	can	MD
cord-002407-25cawzi0	75	6	lead	lead	VB
cord-002407-25cawzi0	75	7	to	to	IN
cord-002407-25cawzi0	75	8	variant	variant	JJ
cord-002407-25cawzi0	75	9	viruses	virus	NNS
cord-002407-25cawzi0	75	10	resistant	resistant	JJ
cord-002407-25cawzi0	75	11	to	to	IN
cord-002407-25cawzi0	75	12	antivirals	antiviral	NNS
cord-002407-25cawzi0	75	13	[	[	-LRB-
cord-002407-25cawzi0	75	14	47	47	CD
cord-002407-25cawzi0	75	15	]	]	-RRB-
cord-002407-25cawzi0	75	16	.	.	.
cord-002407-25cawzi0	76	1	On	on	IN
cord-002407-25cawzi0	76	2	the	the	DT
cord-002407-25cawzi0	76	3	contrary	contrary	NN
cord-002407-25cawzi0	76	4	,	,	,
cord-002407-25cawzi0	76	5	antigenic	antigenic	JJ
cord-002407-25cawzi0	76	6	shift	shift	NN
cord-002407-25cawzi0	76	7	results	result	NNS
cord-002407-25cawzi0	76	8	from	from	IN
cord-002407-25cawzi0	76	9	co	co	NN
cord-002407-25cawzi0	76	10	-	-	NN
cord-002407-25cawzi0	76	11	infection	infection	NN
cord-002407-25cawzi0	76	12	of	of	IN
cord-002407-25cawzi0	76	13	a	a	DT
cord-002407-25cawzi0	76	14	host	host	NN
cord-002407-25cawzi0	76	15	cell	cell	NN
cord-002407-25cawzi0	76	16	or	or	CC
cord-002407-25cawzi0	76	17	organism	organism	NN
cord-002407-25cawzi0	76	18	with	with	IN
cord-002407-25cawzi0	76	19	two	two	CD
cord-002407-25cawzi0	76	20	or	or	CC
cord-002407-25cawzi0	76	21	more	more	JJR
cord-002407-25cawzi0	76	22	IAVs	iav	NNS
cord-002407-25cawzi0	76	23	where	where	WRB
cord-002407-25cawzi0	76	24	vRNAs	vrna	NNS
cord-002407-25cawzi0	76	25	in	in	IN
cord-002407-25cawzi0	76	26	viral	viral	JJ
cord-002407-25cawzi0	76	27	progenies	progeny	NNS
cord-002407-25cawzi0	76	28	are	be	VBP
cord-002407-25cawzi0	76	29	reassorted	reassorte	VBN
cord-002407-25cawzi0	76	30	[	[	-LRB-
cord-002407-25cawzi0	76	31	12	12	CD
cord-002407-25cawzi0	76	32	,	,	,
cord-002407-25cawzi0	76	33	46	46	CD
cord-002407-25cawzi0	76	34	]	]	-RRB-
cord-002407-25cawzi0	76	35	.	.	.
cord-002407-25cawzi0	77	1	By	by	IN
cord-002407-25cawzi0	77	2	obtaining	obtain	VBG
cord-002407-25cawzi0	77	3	viral	viral	JJ
cord-002407-25cawzi0	77	4	segment	segment	NN
cord-002407-25cawzi0	77	5	constellations	constellation	NNS
cord-002407-25cawzi0	77	6	that	that	WDT
cord-002407-25cawzi0	77	7	confer	confer	VBP
cord-002407-25cawzi0	77	8	influenza	influenza	NN
cord-002407-25cawzi0	77	9	virus	virus	NN
cord-002407-25cawzi0	77	10	optimal	optimal	JJ
cord-002407-25cawzi0	77	11	replication	replication	NN
cord-002407-25cawzi0	77	12	,	,	,
cord-002407-25cawzi0	77	13	transmissibility	transmissibility	NN
cord-002407-25cawzi0	77	14	and	and	CC
cord-002407-25cawzi0	77	15	immunologic	immunologic	JJ
cord-002407-25cawzi0	77	16	escape	escape	NN
cord-002407-25cawzi0	77	17	,	,	,
cord-002407-25cawzi0	77	18	reassortant	reassortant	JJ
cord-002407-25cawzi0	77	19	IAVs	iav	NNS
cord-002407-25cawzi0	77	20	can	can	MD
cord-002407-25cawzi0	77	21	lead	lead	VB
cord-002407-25cawzi0	77	22	to	to	IN
cord-002407-25cawzi0	77	23	a	a	DT
cord-002407-25cawzi0	77	24	pandemic	pandemic	NN
cord-002407-25cawzi0	77	25	in	in	IN
cord-002407-25cawzi0	77	26	immunologically	immunologically	RB
cord-002407-25cawzi0	77	27	-	-	HYPH
cord-002407-25cawzi0	77	28	naive	naive	JJ
cord-002407-25cawzi0	77	29	populations	population	NNS
cord-002407-25cawzi0	77	30	.	.	.
cord-002407-25cawzi0	78	1	IAVs	IAVs	NNP
cord-002407-25cawzi0	78	2	and	and	CC
cord-002407-25cawzi0	78	3	IBVs	ibv	NNS
cord-002407-25cawzi0	78	4	can	can	MD
cord-002407-25cawzi0	78	5	reassort	reassort	VB
cord-002407-25cawzi0	78	6	intratypically	intratypically	RB
cord-002407-25cawzi0	78	7	between	between	IN
cord-002407-25cawzi0	78	8	subtypes	subtype	NNS
cord-002407-25cawzi0	78	9	or	or	CC
cord-002407-25cawzi0	78	10	lineages	lineage	NNS
cord-002407-25cawzi0	78	11	,	,	,
cord-002407-25cawzi0	78	12	but	but	CC
cord-002407-25cawzi0	78	13	intertypic	intertypic	NNP
cord-002407-25cawzi0	78	14	reassortment	reassortment	NNP
cord-002407-25cawzi0	78	15	,	,	,
cord-002407-25cawzi0	78	16	or	or	CC
cord-002407-25cawzi0	78	17	genetic	genetic	JJ
cord-002407-25cawzi0	78	18	swapping	swapping	NN
cord-002407-25cawzi0	78	19	of	of	IN
cord-002407-25cawzi0	78	20	segments	segment	NNS
cord-002407-25cawzi0	78	21	between	between	IN
cord-002407-25cawzi0	78	22	IAV	IAV	NNP
cord-002407-25cawzi0	78	23	and	and	CC
cord-002407-25cawzi0	78	24	IBV	IBV	NNP
cord-002407-25cawzi0	78	25	,	,	,
cord-002407-25cawzi0	78	26	has	have	VBZ
cord-002407-25cawzi0	78	27	not	not	RB
cord-002407-25cawzi0	78	28	been	be	VBN
cord-002407-25cawzi0	78	29	reported	report	VBN
cord-002407-25cawzi0	78	30	[	[	-LRB-
cord-002407-25cawzi0	78	31	21	21	CD
cord-002407-25cawzi0	78	32	,	,	,
cord-002407-25cawzi0	78	33	48	48	CD
cord-002407-25cawzi0	78	34	,	,	,
cord-002407-25cawzi0	78	35	49	49	CD
cord-002407-25cawzi0	78	36	]	]	-RRB-
cord-002407-25cawzi0	78	37	.	.	.
cord-002407-25cawzi0	79	1	The	the	DT
cord-002407-25cawzi0	79	2	absence	absence	NN
cord-002407-25cawzi0	79	3	of	of	IN
cord-002407-25cawzi0	79	4	intertypic	intertypic	JJ
cord-002407-25cawzi0	79	5	reassortment	reassortment	NN
cord-002407-25cawzi0	79	6	is	be	VBZ
cord-002407-25cawzi0	79	7	mediated	mediate	VBN
cord-002407-25cawzi0	79	8	by	by	IN
cord-002407-25cawzi0	79	9	the	the	DT
cord-002407-25cawzi0	79	10	lack	lack	NN
cord-002407-25cawzi0	79	11	of	of	IN
cord-002407-25cawzi0	79	12	compatible	compatible	JJ
cord-002407-25cawzi0	79	13	packaging	packaging	NN
cord-002407-25cawzi0	79	14	signals	signal	NNS
cord-002407-25cawzi0	79	15	between	between	IN
cord-002407-25cawzi0	79	16	IAV	IAV	NNP
cord-002407-25cawzi0	79	17	and	and	CC
cord-002407-25cawzi0	79	18	IBV	IBV	NNP
cord-002407-25cawzi0	79	19	[	[	-LRB-
cord-002407-25cawzi0	79	20	12	12	CD
cord-002407-25cawzi0	79	21	]	]	-RRB-
cord-002407-25cawzi0	79	22	.	.	.
cord-002407-25cawzi0	80	1	In	in	IN
cord-002407-25cawzi0	80	2	the	the	DT
cord-002407-25cawzi0	80	3	last	last	JJ
cord-002407-25cawzi0	80	4	century	century	NN
cord-002407-25cawzi0	80	5	,	,	,
cord-002407-25cawzi0	80	6	three	three	CD
cord-002407-25cawzi0	80	7	IAV	IAV	NNP
cord-002407-25cawzi0	80	8	pandemics	pandemic	NNS
cord-002407-25cawzi0	80	9	have	have	VBP
cord-002407-25cawzi0	80	10	occurred	occur	VBN
cord-002407-25cawzi0	80	11	:	:	:
cord-002407-25cawzi0	80	12	the	the	DT
cord-002407-25cawzi0	80	13	H1N1	H1N1	NNP
cord-002407-25cawzi0	80	14	Spanish	spanish	JJ
cord-002407-25cawzi0	80	15	flu	flu	NN
cord-002407-25cawzi0	80	16	of	of	IN
cord-002407-25cawzi0	80	17	1918	1918	CD
cord-002407-25cawzi0	80	18	,	,	,
cord-002407-25cawzi0	80	19	the	the	DT
cord-002407-25cawzi0	80	20	H2N2	H2N2	NNP
cord-002407-25cawzi0	80	21	Asian	asian	JJ
cord-002407-25cawzi0	80	22	flu	flu	NN
cord-002407-25cawzi0	80	23	of	of	IN
cord-002407-25cawzi0	80	24	1957	1957	CD
cord-002407-25cawzi0	80	25	and	and	CC
cord-002407-25cawzi0	80	26	the	the	DT
cord-002407-25cawzi0	80	27	H3N2	H3N2	NNP
cord-002407-25cawzi0	80	28	Hong	Hong	NNP
cord-002407-25cawzi0	80	29	Kong	Kong	NNP
cord-002407-25cawzi0	80	30	flu	flu	NN
cord-002407-25cawzi0	80	31	of	of	IN
cord-002407-25cawzi0	80	32	1968	1968	CD
cord-002407-25cawzi0	80	33	[	[	-LRB-
cord-002407-25cawzi0	80	34	44	44	CD
cord-002407-25cawzi0	80	35	,	,	,
cord-002407-25cawzi0	80	36	50	50	CD
cord-002407-25cawzi0	80	37	]	]	-RRB-
cord-002407-25cawzi0	80	38	.	.	.
cord-002407-25cawzi0	81	1	Of	of	IN
cord-002407-25cawzi0	81	2	these	these	DT
cord-002407-25cawzi0	81	3	three	three	CD
cord-002407-25cawzi0	81	4	,	,	,
cord-002407-25cawzi0	81	5	the	the	DT
cord-002407-25cawzi0	81	6	1918	1918	CD
cord-002407-25cawzi0	81	7	H1N1	H1N1	NNP
cord-002407-25cawzi0	81	8	Spanish	spanish	JJ
cord-002407-25cawzi0	81	9	flu	flu	NN
cord-002407-25cawzi0	81	10	was	be	VBD
cord-002407-25cawzi0	81	11	particularly	particularly	RB
cord-002407-25cawzi0	81	12	fatal	fatal	JJ
cord-002407-25cawzi0	81	13	and	and	CC
cord-002407-25cawzi0	81	14	responsible	responsible	JJ
cord-002407-25cawzi0	81	15	for	for	IN
cord-002407-25cawzi0	81	16	approximately	approximately	RB
cord-002407-25cawzi0	81	17	50	50	CD
cord-002407-25cawzi0	81	18	million	million	CD
cord-002407-25cawzi0	81	19	deaths	death	NNS
cord-002407-25cawzi0	81	20	around	around	IN
cord-002407-25cawzi0	81	21	the	the	DT
cord-002407-25cawzi0	81	22	world	world	NN
cord-002407-25cawzi0	81	23	[	[	-LRB-
cord-002407-25cawzi0	81	24	51	51	CD
cord-002407-25cawzi0	81	25	]	]	-RRB-
cord-002407-25cawzi0	81	26	.	.	.
cord-002407-25cawzi0	82	1	Although	although	IN
cord-002407-25cawzi0	82	2	not	not	RB
cord-002407-25cawzi0	82	3	classified	classify	VBN
cord-002407-25cawzi0	82	4	as	as	IN
cord-002407-25cawzi0	82	5	true	true	JJ
cord-002407-25cawzi0	82	6	pandemics	pandemic	NNS
cord-002407-25cawzi0	82	7	,	,	,
cord-002407-25cawzi0	82	8	three	three	CD
cord-002407-25cawzi0	82	9	epidemics	epidemic	NNS
cord-002407-25cawzi0	82	10	of	of	IN
cord-002407-25cawzi0	82	11	influenza	influenza	NN
cord-002407-25cawzi0	82	12	H1N1	H1N1	NNP
cord-002407-25cawzi0	82	13	viruses	virus	NNS
cord-002407-25cawzi0	82	14	in	in	IN
cord-002407-25cawzi0	82	15	1947	1947	CD
cord-002407-25cawzi0	82	16	,	,	,
cord-002407-25cawzi0	82	17	1976	1976	CD
cord-002407-25cawzi0	82	18	and	and	CC
cord-002407-25cawzi0	82	19	1977	1977	CD
cord-002407-25cawzi0	82	20	were	be	VBD
cord-002407-25cawzi0	82	21	feared	fear	VBN
cord-002407-25cawzi0	82	22	to	to	TO
cord-002407-25cawzi0	82	23	have	have	VB
cord-002407-25cawzi0	82	24	pandemic	pandemic	NN
cord-002407-25cawzi0	82	25	potential	potential	NN
cord-002407-25cawzi0	82	26	.	.	.
cord-002407-25cawzi0	83	1	In	in	IN
cord-002407-25cawzi0	83	2	2009	2009	CD
cord-002407-25cawzi0	83	3	,	,	,
cord-002407-25cawzi0	83	4	a	a	DT
cord-002407-25cawzi0	83	5	swine	swine	NN
cord-002407-25cawzi0	83	6	-	-	HYPH
cord-002407-25cawzi0	83	7	origin	origin	NN
cord-002407-25cawzi0	83	8	H1N1	H1N1	NNP
cord-002407-25cawzi0	83	9	IAV	IAV	NNP
cord-002407-25cawzi0	83	10	was	be	VBD
cord-002407-25cawzi0	83	11	responsible	responsible	JJ
cord-002407-25cawzi0	83	12	for	for	IN
cord-002407-25cawzi0	83	13	the	the	DT
cord-002407-25cawzi0	83	14	first	first	JJ
cord-002407-25cawzi0	83	15	influenza	influenza	NN
cord-002407-25cawzi0	83	16	pandemic	pandemic	NN
cord-002407-25cawzi0	83	17	of	of	IN
cord-002407-25cawzi0	83	18	the	the	DT
cord-002407-25cawzi0	83	19	21st	21st	JJ
cord-002407-25cawzi0	83	20	century	century	NN
cord-002407-25cawzi0	83	21	and	and	CC
cord-002407-25cawzi0	83	22	infected	infect	VBN
cord-002407-25cawzi0	83	23	,	,	,
cord-002407-25cawzi0	83	24	in	in	IN
cord-002407-25cawzi0	83	25	less	less	JJR
cord-002407-25cawzi0	83	26	than	than	IN
cord-002407-25cawzi0	83	27	one	one	CD
cord-002407-25cawzi0	83	28	year	year	NN
cord-002407-25cawzi0	83	29	,	,	,
cord-002407-25cawzi0	83	30	more	more	JJR
cord-002407-25cawzi0	83	31	than	than	IN
cord-002407-25cawzi0	83	32	600,000	600,000	CD
cord-002407-25cawzi0	83	33	individuals	individual	NNS
cord-002407-25cawzi0	83	34	around	around	IN
cord-002407-25cawzi0	83	35	the	the	DT
cord-002407-25cawzi0	83	36	world	world	NN
cord-002407-25cawzi0	83	37	[	[	-LRB-
cord-002407-25cawzi0	83	38	52	52	CD
cord-002407-25cawzi0	83	39	,	,	,
cord-002407-25cawzi0	83	40	53	53	CD
cord-002407-25cawzi0	83	41	]	]	-RRB-
cord-002407-25cawzi0	83	42	.	.	.
cord-002407-25cawzi0	84	1	Although	although	IN
cord-002407-25cawzi0	84	2	influenza	influenza	NN
cord-002407-25cawzi0	84	3	virus	virus	NN
cord-002407-25cawzi0	84	4	infections	infection	NNS
cord-002407-25cawzi0	84	5	are	be	VBP
cord-002407-25cawzi0	84	6	primarily	primarily	RB
cord-002407-25cawzi0	84	7	spread	spread	VBN
cord-002407-25cawzi0	84	8	by	by	IN
cord-002407-25cawzi0	84	9	person	person	NN
cord-002407-25cawzi0	84	10	-	-	HYPH
cord-002407-25cawzi0	84	11	to	to	IN
cord-002407-25cawzi0	84	12	-	-	HYPH
cord-002407-25cawzi0	84	13	person	person	NN
cord-002407-25cawzi0	84	14	transmission	transmission	NN
cord-002407-25cawzi0	84	15	via	via	IN
cord-002407-25cawzi0	84	16	aerosolized	aerosolize	VBN
cord-002407-25cawzi0	84	17	droplets	droplet	NNS
cord-002407-25cawzi0	84	18	,	,	,
cord-002407-25cawzi0	84	19	infection	infection	NN
cord-002407-25cawzi0	84	20	with	with	IN
cord-002407-25cawzi0	84	21	new	new	JJ
cord-002407-25cawzi0	84	22	avian	avian	JJ
cord-002407-25cawzi0	84	23	-	-	HYPH
cord-002407-25cawzi0	84	24	or	or	CC
cord-002407-25cawzi0	84	25	swine	swine	NN
cord-002407-25cawzi0	84	26	-	-	HYPH
cord-002407-25cawzi0	84	27	origin	origin	NN
cord-002407-25cawzi0	84	28	IAV	IAV	NNP
cord-002407-25cawzi0	84	29	can	can	MD
cord-002407-25cawzi0	84	30	take	take	VB
cord-002407-25cawzi0	84	31	place	place	NN
cord-002407-25cawzi0	84	32	and	and	CC
cord-002407-25cawzi0	84	33	may	may	MD
cord-002407-25cawzi0	84	34	have	have	VB
cord-002407-25cawzi0	84	35	great	great	JJ
cord-002407-25cawzi0	84	36	risk	risk	NN
cord-002407-25cawzi0	84	37	for	for	IN
cord-002407-25cawzi0	84	38	pandemic	pandemic	NN
cord-002407-25cawzi0	84	39	potential	potential	NN
cord-002407-25cawzi0	84	40	if	if	IN
cord-002407-25cawzi0	84	41	the	the	DT
cord-002407-25cawzi0	84	42	virus	virus	NN
cord-002407-25cawzi0	84	43	acquires	acquire	VBZ
cord-002407-25cawzi0	84	44	the	the	DT
cord-002407-25cawzi0	84	45	ability	ability	NN
cord-002407-25cawzi0	84	46	to	to	TO
cord-002407-25cawzi0	84	47	be	be	VB
cord-002407-25cawzi0	84	48	transmitted	transmit	VBN
cord-002407-25cawzi0	84	49	between	between	IN
cord-002407-25cawzi0	84	50	humans	human	NNS
cord-002407-25cawzi0	84	51	[	[	-LRB-
cord-002407-25cawzi0	84	52	54	54	CD
cord-002407-25cawzi0	84	53	,	,	,
cord-002407-25cawzi0	84	54	55	55	CD
cord-002407-25cawzi0	84	55	]	]	-RRB-
cord-002407-25cawzi0	84	56	.	.	.
cord-002407-25cawzi0	85	1	IBVs	IBVs	NNP
cord-002407-25cawzi0	85	2	usually	usually	RB
cord-002407-25cawzi0	85	3	contribute	contribute	VBP
cord-002407-25cawzi0	85	4	less	less	JJR
cord-002407-25cawzi0	85	5	to	to	TO
cord-002407-25cawzi0	85	6	seasonal	seasonal	JJ
cord-002407-25cawzi0	85	7	epidemics	epidemic	NNS
cord-002407-25cawzi0	85	8	than	than	IN
cord-002407-25cawzi0	85	9	IAVs	iav	NNS
cord-002407-25cawzi0	85	10	of	of	IN
cord-002407-25cawzi0	85	11	the	the	DT
cord-002407-25cawzi0	85	12	H3N2	H3N2	NNP
cord-002407-25cawzi0	85	13	subtype	subtype	NN
cord-002407-25cawzi0	85	14	,	,	,
cord-002407-25cawzi0	85	15	but	but	CC
cord-002407-25cawzi0	85	16	they	-PRON-	PRP
cord-002407-25cawzi0	85	17	contribute	contribute	VBP
cord-002407-25cawzi0	85	18	more	more	JJR
cord-002407-25cawzi0	85	19	than	than	IN
cord-002407-25cawzi0	85	20	type	type	NN
cord-002407-25cawzi0	85	21	A	a	DT
cord-002407-25cawzi0	85	22	H1N1	H1N1	NNP
cord-002407-25cawzi0	85	23	influenza	influenza	NN
cord-002407-25cawzi0	85	24	strains	strain	NNS
cord-002407-25cawzi0	85	25	and	and	CC
cord-002407-25cawzi0	85	26	are	be	VBP
cord-002407-25cawzi0	85	27	the	the	DT
cord-002407-25cawzi0	85	28	predominant	predominant	JJ
cord-002407-25cawzi0	85	29	circulating	circulate	VBG
cord-002407-25cawzi0	85	30	virus	virus	NN
cord-002407-25cawzi0	85	31	strains	strain	NNS
cord-002407-25cawzi0	85	32	once	once	RB
cord-002407-25cawzi0	85	33	every	every	DT
cord-002407-25cawzi0	85	34	three	three	CD
cord-002407-25cawzi0	85	35	years	year	NNS
cord-002407-25cawzi0	85	36	[	[	-LRB-
cord-002407-25cawzi0	85	37	23	23	CD
cord-002407-25cawzi0	85	38	]	]	-RRB-
cord-002407-25cawzi0	85	39	[	[	-LRB-
cord-002407-25cawzi0	85	40	24	24	CD
cord-002407-25cawzi0	85	41	]	]	-RRB-
cord-002407-25cawzi0	85	42	[	[	-LRB-
cord-002407-25cawzi0	85	43	25	25	CD
cord-002407-25cawzi0	85	44	]	]	-RRB-
cord-002407-25cawzi0	85	45	.	.	.
cord-002407-25cawzi0	86	1	Moreover	moreover	RB
cord-002407-25cawzi0	86	2	,	,	,
cord-002407-25cawzi0	86	3	during	during	IN
cord-002407-25cawzi0	86	4	the	the	DT
cord-002407-25cawzi0	86	5	last	last	JJ
cord-002407-25cawzi0	86	6	decade	decade	NN
cord-002407-25cawzi0	86	7	,	,	,
cord-002407-25cawzi0	86	8	IBV	IBV	NNP
cord-002407-25cawzi0	86	9	has	have	VBZ
cord-002407-25cawzi0	86	10	been	be	VBN
cord-002407-25cawzi0	86	11	the	the	DT
cord-002407-25cawzi0	86	12	cause	cause	NN
cord-002407-25cawzi0	86	13	of	of	IN
cord-002407-25cawzi0	86	14	several	several	JJ
cord-002407-25cawzi0	86	15	acute	acute	JJ
cord-002407-25cawzi0	86	16	respiratory	respiratory	JJ
cord-002407-25cawzi0	86	17	illness	illness	NN
cord-002407-25cawzi0	86	18	outbreaks	outbreak	NNS
cord-002407-25cawzi0	86	19	[	[	-LRB-
cord-002407-25cawzi0	86	20	56	56	CD
cord-002407-25cawzi0	86	21	]	]	-RRB-
cord-002407-25cawzi0	86	22	[	[	-LRB-
cord-002407-25cawzi0	86	23	57	57	CD
cord-002407-25cawzi0	86	24	]	]	-RRB-
cord-002407-25cawzi0	86	25	[	[	-LRB-
cord-002407-25cawzi0	86	26	58	58	CD
cord-002407-25cawzi0	86	27	]	]	-RRB-
cord-002407-25cawzi0	86	28	[	[	-LRB-
cord-002407-25cawzi0	86	29	59	59	CD
cord-002407-25cawzi0	86	30	]	]	-RRB-
cord-002407-25cawzi0	86	31	[	[	-LRB-
cord-002407-25cawzi0	86	32	60	60	CD
cord-002407-25cawzi0	86	33	]	]	-RRB-
cord-002407-25cawzi0	86	34	.	.	.
cord-002407-25cawzi0	87	1	To	to	IN
cord-002407-25cawzi0	87	2	date	date	NN
cord-002407-25cawzi0	87	3	,	,	,
cord-002407-25cawzi0	87	4	no	no	DT
cord-002407-25cawzi0	87	5	influenza	influenza	NN
cord-002407-25cawzi0	87	6	pandemics	pandemic	NNS
cord-002407-25cawzi0	87	7	have	have	VBP
cord-002407-25cawzi0	87	8	been	be	VBN
cord-002407-25cawzi0	87	9	linked	link	VBN
cord-002407-25cawzi0	87	10	to	to	IN
cord-002407-25cawzi0	87	11	IBVs	ibv	NNS
cord-002407-25cawzi0	87	12	.	.	.
cord-002407-25cawzi0	88	1	Public	public	JJ
cord-002407-25cawzi0	88	2	health	health	NN
cord-002407-25cawzi0	88	3	concerns	concern	NNS
cord-002407-25cawzi0	88	4	posed	pose	VBN
cord-002407-25cawzi0	88	5	by	by	IN
cord-002407-25cawzi0	88	6	influenza	influenza	NN
cord-002407-25cawzi0	88	7	virus	virus	NN
cord-002407-25cawzi0	88	8	infections	infection	NNS
cord-002407-25cawzi0	88	9	are	be	VBP
cord-002407-25cawzi0	88	10	aggravated	aggravate	VBN
cord-002407-25cawzi0	88	11	by	by	IN
cord-002407-25cawzi0	88	12	the	the	DT
cord-002407-25cawzi0	88	13	ability	ability	NN
cord-002407-25cawzi0	88	14	of	of	IN
cord-002407-25cawzi0	88	15	influenza	influenza	NN
cord-002407-25cawzi0	88	16	viruses	virus	NNS
cord-002407-25cawzi0	88	17	to	to	TO
cord-002407-25cawzi0	88	18	efficiently	efficiently	RB
cord-002407-25cawzi0	88	19	transmit	transmit	VB
cord-002407-25cawzi0	88	20	and	and	CC
cord-002407-25cawzi0	88	21	the	the	DT
cord-002407-25cawzi0	88	22	limited	limited	JJ
cord-002407-25cawzi0	88	23	therapeutic	therapeutic	JJ
cord-002407-25cawzi0	88	24	options	option	NNS
cord-002407-25cawzi0	88	25	to	to	TO
cord-002407-25cawzi0	88	26	treat	treat	VB
cord-002407-25cawzi0	88	27	viral	viral	JJ
cord-002407-25cawzi0	88	28	infections	infection	NNS
cord-002407-25cawzi0	88	29	[	[	-LRB-
cord-002407-25cawzi0	88	30	37	37	CD
cord-002407-25cawzi0	88	31	]	]	-RRB-
cord-002407-25cawzi0	88	32	.	.	.
cord-002407-25cawzi0	89	1	Thus	thus	RB
cord-002407-25cawzi0	89	2	,	,	,
cord-002407-25cawzi0	89	3	vaccination	vaccination	NN
cord-002407-25cawzi0	89	4	remains	remain	VBZ
cord-002407-25cawzi0	89	5	our	-PRON-	PRP$
cord-002407-25cawzi0	89	6	best	good	JJS
cord-002407-25cawzi0	89	7	medical	medical	JJ
cord-002407-25cawzi0	89	8	intervention	intervention	NN
cord-002407-25cawzi0	89	9	to	to	TO
cord-002407-25cawzi0	89	10	protect	protect	VB
cord-002407-25cawzi0	89	11	humans	human	NNS
cord-002407-25cawzi0	89	12	against	against	IN
cord-002407-25cawzi0	89	13	seasonal	seasonal	JJ
cord-002407-25cawzi0	89	14	influenza	influenza	NN
cord-002407-25cawzi0	89	15	virus	virus	NN
cord-002407-25cawzi0	89	16	.	.	.
cord-002407-25cawzi0	90	1	However	however	RB
cord-002407-25cawzi0	90	2	,	,	,
cord-002407-25cawzi0	90	3	the	the	DT
cord-002407-25cawzi0	90	4	efficiency	efficiency	NN
cord-002407-25cawzi0	90	5	of	of	IN
cord-002407-25cawzi0	90	6	current	current	JJ
cord-002407-25cawzi0	90	7	influenza	influenza	NN
cord-002407-25cawzi0	90	8	vaccines	vaccine	NNS
cord-002407-25cawzi0	90	9	is	be	VBZ
cord-002407-25cawzi0	90	10	suboptimal	suboptimal	JJ
cord-002407-25cawzi0	90	11	[	[	-LRB-
cord-002407-25cawzi0	90	12	61	61	CD
cord-002407-25cawzi0	90	13	]	]	-RRB-
cord-002407-25cawzi0	90	14	.	.	.
cord-002407-25cawzi0	91	1	The	the	DT
cord-002407-25cawzi0	91	2	segmented	segmented	JJ
cord-002407-25cawzi0	91	3	genome	genome	NN
cord-002407-25cawzi0	91	4	of	of	IN
cord-002407-25cawzi0	91	5	influenza	influenza	NN
cord-002407-25cawzi0	91	6	viruses	virus	NNS
cord-002407-25cawzi0	91	7	provides	provide	VBZ
cord-002407-25cawzi0	91	8	an	an	DT
cord-002407-25cawzi0	91	9	evolutionary	evolutionary	JJ
cord-002407-25cawzi0	91	10	advantage	advantage	NN
cord-002407-25cawzi0	91	11	of	of	IN
cord-002407-25cawzi0	91	12	reassortment	reassortment	NN
cord-002407-25cawzi0	91	13	,	,	,
cord-002407-25cawzi0	91	14	or	or	CC
cord-002407-25cawzi0	91	15	the	the	DT
cord-002407-25cawzi0	91	16	exchange	exchange	NN
cord-002407-25cawzi0	91	17	of	of	IN
cord-002407-25cawzi0	91	18	viral	viral	JJ
cord-002407-25cawzi0	91	19	genome	genome	NN
cord-002407-25cawzi0	91	20	segments	segment	NNS
cord-002407-25cawzi0	91	21	between	between	IN
cord-002407-25cawzi0	91	22	different	different	JJ
cord-002407-25cawzi0	91	23	viral	viral	JJ
cord-002407-25cawzi0	91	24	strains	strain	NNS
cord-002407-25cawzi0	91	25	within	within	IN
cord-002407-25cawzi0	91	26	the	the	DT
cord-002407-25cawzi0	91	27	same	same	JJ
cord-002407-25cawzi0	91	28	type	type	NN
cord-002407-25cawzi0	91	29	.	.	.
cord-002407-25cawzi0	92	1	In	in	IN
cord-002407-25cawzi0	92	2	addition	addition	NN
cord-002407-25cawzi0	92	3	to	to	IN
cord-002407-25cawzi0	92	4	this	this	DT
cord-002407-25cawzi0	92	5	exchange	exchange	NN
cord-002407-25cawzi0	92	6	of	of	IN
cord-002407-25cawzi0	92	7	genome	genome	NN
cord-002407-25cawzi0	92	8	material	material	NN
cord-002407-25cawzi0	92	9	(	(	-LRB-
cord-002407-25cawzi0	92	10	or	or	CC
cord-002407-25cawzi0	92	11	antigenic	antigenic	JJ
cord-002407-25cawzi0	92	12	shift	shift	NN
cord-002407-25cawzi0	92	13	)	)	-RRB-
cord-002407-25cawzi0	92	14	,	,	,
cord-002407-25cawzi0	92	15	influenza	influenza	NN
cord-002407-25cawzi0	92	16	viruses	virus	NNS
cord-002407-25cawzi0	92	17	can	can	MD
cord-002407-25cawzi0	92	18	introduce	introduce	VB
cord-002407-25cawzi0	92	19	mutations	mutation	NNS
cord-002407-25cawzi0	92	20	in	in	IN
cord-002407-25cawzi0	92	21	their	-PRON-	PRP$
cord-002407-25cawzi0	92	22	genomes	genome	NNS
cord-002407-25cawzi0	92	23	(	(	-LRB-
cord-002407-25cawzi0	92	24	or	or	CC
cord-002407-25cawzi0	92	25	antigenic	antigenic	JJ
cord-002407-25cawzi0	92	26	drift	drift	NN
cord-002407-25cawzi0	92	27	)	)	-RRB-
cord-002407-25cawzi0	92	28	,	,	,
cord-002407-25cawzi0	92	29	leading	lead	VBG
cord-002407-25cawzi0	92	30	to	to	IN
cord-002407-25cawzi0	92	31	viral	viral	JJ
cord-002407-25cawzi0	92	32	mutants	mutant	NNS
cord-002407-25cawzi0	92	33	with	with	IN
cord-002407-25cawzi0	92	34	resistance	resistance	NN
cord-002407-25cawzi0	92	35	against	against	IN
cord-002407-25cawzi0	92	36	current	current	JJ
cord-002407-25cawzi0	92	37	antivirals	antiviral	NNS
cord-002407-25cawzi0	92	38	or	or	CC
cord-002407-25cawzi0	92	39	NAbs	NAbs	NNP
cord-002407-25cawzi0	92	40	[	[	-LRB-
cord-002407-25cawzi0	92	41	62	62	CD
cord-002407-25cawzi0	92	42	]	]	-RRB-
cord-002407-25cawzi0	92	43	[	[	-LRB-
cord-002407-25cawzi0	92	44	63	63	CD
cord-002407-25cawzi0	92	45	]	]	-RRB-
cord-002407-25cawzi0	92	46	[	[	-LRB-
cord-002407-25cawzi0	92	47	64	64	CD
cord-002407-25cawzi0	92	48	]	]	-RRB-
cord-002407-25cawzi0	92	49	.	.	.
cord-002407-25cawzi0	93	1	Because	because	IN
cord-002407-25cawzi0	93	2	of	of	IN
cord-002407-25cawzi0	93	3	the	the	DT
cord-002407-25cawzi0	93	4	antigenic	antigenic	JJ
cord-002407-25cawzi0	93	5	drift	drift	NN
cord-002407-25cawzi0	93	6	,	,	,
cord-002407-25cawzi0	93	7	influenza	influenza	NN
cord-002407-25cawzi0	93	8	vaccines	vaccine	NNS
cord-002407-25cawzi0	93	9	need	need	VBP
cord-002407-25cawzi0	93	10	to	to	TO
cord-002407-25cawzi0	93	11	be	be	VB
cord-002407-25cawzi0	93	12	reformulated	reformulate	VBN
cord-002407-25cawzi0	93	13	yearly	yearly	RB
cord-002407-25cawzi0	93	14	to	to	TO
cord-002407-25cawzi0	93	15	ensure	ensure	VB
cord-002407-25cawzi0	93	16	that	that	IN
cord-002407-25cawzi0	93	17	the	the	DT
cord-002407-25cawzi0	93	18	HA	HA	NNP
cord-002407-25cawzi0	93	19	and	and	CC
cord-002407-25cawzi0	93	20	NA	NA	NNP
cord-002407-25cawzi0	93	21	present	present	JJ
cord-002407-25cawzi0	93	22	in	in	IN
cord-002407-25cawzi0	93	23	the	the	DT
cord-002407-25cawzi0	93	24	vaccine	vaccine	NN
cord-002407-25cawzi0	93	25	match	match	VBP
cord-002407-25cawzi0	93	26	those	those	DT
cord-002407-25cawzi0	93	27	present	present	JJ
cord-002407-25cawzi0	93	28	in	in	IN
cord-002407-25cawzi0	93	29	circulating	circulate	VBG
cord-002407-25cawzi0	93	30	seasonal	seasonal	JJ
cord-002407-25cawzi0	93	31	viruses	virus	NNS
cord-002407-25cawzi0	93	32	.	.	.
cord-002407-25cawzi0	94	1	To	to	IN
cord-002407-25cawzi0	94	2	date	date	NN
cord-002407-25cawzi0	94	3	,	,	,
cord-002407-25cawzi0	94	4	three	three	CD
cord-002407-25cawzi0	94	5	types	type	NNS
cord-002407-25cawzi0	94	6	of	of	IN
cord-002407-25cawzi0	94	7	influenza	influenza	NN
cord-002407-25cawzi0	94	8	virus	virus	NN
cord-002407-25cawzi0	94	9	vaccines	vaccine	NNS
cord-002407-25cawzi0	94	10	are	be	VBP
cord-002407-25cawzi0	94	11	approved	approve	VBN
cord-002407-25cawzi0	94	12	by	by	IN
cord-002407-25cawzi0	94	13	the	the	DT
cord-002407-25cawzi0	94	14	Food	Food	NNP
cord-002407-25cawzi0	94	15	and	and	CC
cord-002407-25cawzi0	94	16	Drug	Drug	NNP
cord-002407-25cawzi0	94	17	Administration	Administration	NNP
cord-002407-25cawzi0	94	18	(	(	-LRB-
cord-002407-25cawzi0	94	19	FDA	FDA	NNP
cord-002407-25cawzi0	94	20	)	)	-RRB-
cord-002407-25cawzi0	94	21	for	for	IN
cord-002407-25cawzi0	94	22	human	human	JJ
cord-002407-25cawzi0	94	23	use	use	NN
cord-002407-25cawzi0	94	24	:	:	:
cord-002407-25cawzi0	94	25	recombinant	recombinant	JJ
cord-002407-25cawzi0	94	26	viral	viral	JJ
cord-002407-25cawzi0	94	27	HA	HA	NNP
cord-002407-25cawzi0	94	28	,	,	,
cord-002407-25cawzi0	94	29	inactivated	inactivate	VBN
cord-002407-25cawzi0	94	30	virus	virus	NN
cord-002407-25cawzi0	94	31	and	and	CC
cord-002407-25cawzi0	94	32	live	live	RB
cord-002407-25cawzi0	94	33	-	-	HYPH
cord-002407-25cawzi0	94	34	attenuated	attenuate	VBN
cord-002407-25cawzi0	94	35	viruses	virus	NNS
cord-002407-25cawzi0	94	36	[	[	-LRB-
cord-002407-25cawzi0	94	37	65	65	CD
cord-002407-25cawzi0	94	38	]	]	-RRB-
cord-002407-25cawzi0	95	1	[	[	-LRB-
cord-002407-25cawzi0	95	2	66	66	CD
cord-002407-25cawzi0	95	3	]	]	-RRB-
cord-002407-25cawzi0	96	1	[	[	-LRB-
cord-002407-25cawzi0	96	2	67	67	CD
cord-002407-25cawzi0	96	3	]	]	-RRB-
cord-002407-25cawzi0	97	1	[	[	-LRB-
cord-002407-25cawzi0	97	2	68	68	CD
cord-002407-25cawzi0	97	3	]	]	-RRB-
cord-002407-25cawzi0	97	4	[	[	-LRB-
cord-002407-25cawzi0	97	5	69	69	CD
cord-002407-25cawzi0	97	6	]	]	-RRB-
cord-002407-25cawzi0	97	7	.	.	.
cord-002407-25cawzi0	98	1	Regardless	regardless	RB
cord-002407-25cawzi0	98	2	of	of	IN
cord-002407-25cawzi0	98	3	the	the	DT
cord-002407-25cawzi0	98	4	type	type	NN
cord-002407-25cawzi0	98	5	of	of	IN
cord-002407-25cawzi0	98	6	vaccine	vaccine	NN
cord-002407-25cawzi0	98	7	,	,	,
cord-002407-25cawzi0	98	8	seasonal	seasonal	JJ
cord-002407-25cawzi0	98	9	influenza	influenza	NN
cord-002407-25cawzi0	98	10	vaccines	vaccine	NNS
cord-002407-25cawzi0	98	11	contain	contain	VBP
cord-002407-25cawzi0	98	12	antigens	antigen	NNS
cord-002407-25cawzi0	98	13	from	from	IN
cord-002407-25cawzi0	98	14	the	the	DT
cord-002407-25cawzi0	98	15	three	three	CD
cord-002407-25cawzi0	98	16	circulating	circulate	VBG
cord-002407-25cawzi0	98	17	influenza	influenza	NN
cord-002407-25cawzi0	98	18	virus	virus	NN
cord-002407-25cawzi0	98	19	strains	strain	NNS
cord-002407-25cawzi0	98	20	:	:	:
cord-002407-25cawzi0	98	21	IAV	IAV	NNP
cord-002407-25cawzi0	98	22	subtypes	subtype	NNS
cord-002407-25cawzi0	98	23	H1N1	H1N1	NNP
cord-002407-25cawzi0	98	24	and	and	CC
cord-002407-25cawzi0	98	25	H3N2	H3N2	NNP
cord-002407-25cawzi0	98	26	;	;	:
cord-002407-25cawzi0	98	27	and	and	CC
cord-002407-25cawzi0	98	28	IBV	IBV	NNP
cord-002407-25cawzi0	98	29	(	(	-LRB-
cord-002407-25cawzi0	98	30	Victoria	Victoria	NNP
cord-002407-25cawzi0	98	31	-	-	HYPH
cord-002407-25cawzi0	98	32	like	like	JJ
cord-002407-25cawzi0	98	33	or	or	CC
cord-002407-25cawzi0	98	34	Yamagata	Yamagata	NNP
cord-002407-25cawzi0	98	35	-	-	HYPH
cord-002407-25cawzi0	98	36	like	like	JJ
cord-002407-25cawzi0	98	37	lineage	lineage	NN
cord-002407-25cawzi0	98	38	)	)	-RRB-
cord-002407-25cawzi0	98	39	[	[	-LRB-
cord-002407-25cawzi0	98	40	67	67	CD
cord-002407-25cawzi0	98	41	,	,	,
cord-002407-25cawzi0	98	42	70	70	CD
cord-002407-25cawzi0	98	43	]	]	-RRB-
cord-002407-25cawzi0	98	44	.	.	.
cord-002407-25cawzi0	99	1	Recently	recently	RB
cord-002407-25cawzi0	99	2	,	,	,
cord-002407-25cawzi0	99	3	to	to	TO
cord-002407-25cawzi0	99	4	improve	improve	VB
cord-002407-25cawzi0	99	5	the	the	DT
cord-002407-25cawzi0	99	6	efficacy	efficacy	NN
cord-002407-25cawzi0	99	7	of	of	IN
cord-002407-25cawzi0	99	8	seasonal	seasonal	JJ
cord-002407-25cawzi0	99	9	influenza	influenza	NN
cord-002407-25cawzi0	99	10	vaccines	vaccine	NNS
cord-002407-25cawzi0	99	11	,	,	,
cord-002407-25cawzi0	99	12	a	a	DT
cord-002407-25cawzi0	99	13	quadrivalent	quadrivalent	NN
cord-002407-25cawzi0	99	14	influenza	influenza	NN
cord-002407-25cawzi0	99	15	vaccine	vaccine	NN
cord-002407-25cawzi0	99	16	formulation	formulation	NN
cord-002407-25cawzi0	99	17	that	that	WDT
cord-002407-25cawzi0	99	18	includes	include	VBZ
cord-002407-25cawzi0	99	19	both	both	CC
cord-002407-25cawzi0	99	20	IBV	IBV	NNP
cord-002407-25cawzi0	99	21	lineages	lineage	NNS
cord-002407-25cawzi0	99	22	components	component	NNS
cord-002407-25cawzi0	99	23	(	(	-LRB-
cord-002407-25cawzi0	99	24	Victoria	Victoria	NNP
cord-002407-25cawzi0	99	25	-	-	HYPH
cord-002407-25cawzi0	99	26	like	like	NNP
cord-002407-25cawzi0	99	27	and	and	CC
cord-002407-25cawzi0	99	28	Yamagata	Yamagata	NNP
cord-002407-25cawzi0	99	29	-	-	HYPH
cord-002407-25cawzi0	99	30	like	like	JJ
cord-002407-25cawzi0	99	31	lineage	lineage	NN
cord-002407-25cawzi0	99	32	)	)	-RRB-
cord-002407-25cawzi0	99	33	has	have	VBZ
cord-002407-25cawzi0	99	34	been	be	VBN
cord-002407-25cawzi0	99	35	approved	approve	VBN
cord-002407-25cawzi0	99	36	by	by	IN
cord-002407-25cawzi0	99	37	the	the	DT
cord-002407-25cawzi0	99	38	FDA	FDA	NNP
cord-002407-25cawzi0	99	39	[	[	-LRB-
cord-002407-25cawzi0	99	40	14	14	CD
cord-002407-25cawzi0	99	41	]	]	-RRB-
cord-002407-25cawzi0	99	42	.	.	.
cord-002407-25cawzi0	100	1	The	the	DT
cord-002407-25cawzi0	100	2	most	most	RBS
cord-002407-25cawzi0	100	3	common	common	JJ
cord-002407-25cawzi0	100	4	influenza	influenza	NN
cord-002407-25cawzi0	100	5	vaccine	vaccine	NN
cord-002407-25cawzi0	100	6	is	be	VBZ
cord-002407-25cawzi0	100	7	the	the	DT
cord-002407-25cawzi0	100	8	inactivated	inactivate	VBN
cord-002407-25cawzi0	100	9	influenza	influenza	NN
cord-002407-25cawzi0	100	10	vaccine	vaccine	NN
cord-002407-25cawzi0	100	11	(	(	-LRB-
cord-002407-25cawzi0	100	12	IIV	IIV	NNP
cord-002407-25cawzi0	100	13	)	)	-RRB-
cord-002407-25cawzi0	100	14	.	.	.
cord-002407-25cawzi0	101	1	IIV	IIV	NNP
cord-002407-25cawzi0	101	2	,	,	,
cord-002407-25cawzi0	101	3	which	which	WDT
cord-002407-25cawzi0	101	4	is	be	VBZ
cord-002407-25cawzi0	101	5	administered	administer	VBN
cord-002407-25cawzi0	101	6	intramuscularly	intramuscularly	RB
cord-002407-25cawzi0	101	7	,	,	,
cord-002407-25cawzi0	101	8	has	have	VBZ
cord-002407-25cawzi0	101	9	been	be	VBN
cord-002407-25cawzi0	101	10	shown	show	VBN
cord-002407-25cawzi0	101	11	to	to	TO
cord-002407-25cawzi0	101	12	elicit	elicit	VB
cord-002407-25cawzi0	101	13	protective	protective	JJ
cord-002407-25cawzi0	101	14	humoral	humoral	JJ
cord-002407-25cawzi0	101	15	immunity	immunity	NN
cord-002407-25cawzi0	101	16	by	by	IN
cord-002407-25cawzi0	101	17	producing	produce	VBG
cord-002407-25cawzi0	101	18	NAbs	NAbs	NNP
cord-002407-25cawzi0	101	19	that	that	WDT
cord-002407-25cawzi0	101	20	target	target	VBP
cord-002407-25cawzi0	101	21	epitopes	epitope	NNS
cord-002407-25cawzi0	101	22	on	on	IN
cord-002407-25cawzi0	101	23	HA	HA	NNP
cord-002407-25cawzi0	101	24	[	[	-LRB-
cord-002407-25cawzi0	101	25	61	61	CD
cord-002407-25cawzi0	101	26	,	,	,
cord-002407-25cawzi0	101	27	71	71	CD
cord-002407-25cawzi0	101	28	]	]	-RRB-
cord-002407-25cawzi0	101	29	.	.	.
cord-002407-25cawzi0	102	1	In	in	IN
cord-002407-25cawzi0	102	2	contrast	contrast	NN
cord-002407-25cawzi0	102	3	to	to	IN
cord-002407-25cawzi0	102	4	IIV	IIV	NNP
cord-002407-25cawzi0	102	5	,	,	,
cord-002407-25cawzi0	102	6	the	the	DT
cord-002407-25cawzi0	102	7	live	live	RB
cord-002407-25cawzi0	102	8	-	-	HYPH
cord-002407-25cawzi0	102	9	attenuated	attenuate	VBN
cord-002407-25cawzi0	102	10	influenza	influenza	NN
cord-002407-25cawzi0	102	11	vaccine	vaccine	NN
cord-002407-25cawzi0	102	12	(	(	-LRB-
cord-002407-25cawzi0	102	13	LAIV	LAIV	NNP
cord-002407-25cawzi0	102	14	)	)	-RRB-
cord-002407-25cawzi0	102	15	and	and	CC
cord-002407-25cawzi0	102	16	its	-PRON-	PRP$
cord-002407-25cawzi0	102	17	administration	administration	NN
cord-002407-25cawzi0	102	18	mimic	mimic	VBP
cord-002407-25cawzi0	102	19	the	the	DT
cord-002407-25cawzi0	102	20	natural	natural	JJ
cord-002407-25cawzi0	102	21	route	route	NN
cord-002407-25cawzi0	102	22	of	of	IN
cord-002407-25cawzi0	102	23	virus	virus	NN
cord-002407-25cawzi0	102	24	infection	infection	NN
cord-002407-25cawzi0	102	25	,	,	,
cord-002407-25cawzi0	102	26	which	which	WDT
cord-002407-25cawzi0	102	27	consequently	consequently	RB
cord-002407-25cawzi0	102	28	having	have	VBG
cord-002407-25cawzi0	102	29	risks	risk	NNS
cord-002407-25cawzi0	102	30	and	and	CC
cord-002407-25cawzi0	102	31	benefits	benefit	NNS
cord-002407-25cawzi0	102	32	[	[	-LRB-
cord-002407-25cawzi0	102	33	72	72	CD
cord-002407-25cawzi0	102	34	]	]	-RRB-
cord-002407-25cawzi0	102	35	.	.	.
cord-002407-25cawzi0	103	1	An	an	DT
cord-002407-25cawzi0	103	2	advantage	advantage	NN
cord-002407-25cawzi0	103	3	is	be	VBZ
cord-002407-25cawzi0	103	4	that	that	IN
cord-002407-25cawzi0	103	5	LAIV	LAIV	NNP
cord-002407-25cawzi0	103	6	elicits	elicit	VBZ
cord-002407-25cawzi0	103	7	both	both	DT
cord-002407-25cawzi0	103	8	more	more	RBR
cord-002407-25cawzi0	103	9	rapid	rapid	JJ
cord-002407-25cawzi0	103	10	and	and	CC
cord-002407-25cawzi0	103	11	efficient	efficient	JJ
cord-002407-25cawzi0	103	12	innate	innate	JJ
cord-002407-25cawzi0	103	13	and	and	CC
cord-002407-25cawzi0	103	14	adaptive	adaptive	JJ
cord-002407-25cawzi0	103	15	immune	immune	JJ
cord-002407-25cawzi0	103	16	responses	response	NNS
cord-002407-25cawzi0	103	17	[	[	-LRB-
cord-002407-25cawzi0	103	18	65	65	CD
cord-002407-25cawzi0	103	19	]	]	-RRB-
cord-002407-25cawzi0	103	20	and	and	CC
cord-002407-25cawzi0	103	21	can	can	MD
cord-002407-25cawzi0	103	22	provide	provide	VB
cord-002407-25cawzi0	103	23	more	more	RBR
cord-002407-25cawzi0	103	24	efficient	efficient	JJ
cord-002407-25cawzi0	103	25	cross	cross	JJ
cord-002407-25cawzi0	103	26	-	-	JJ
cord-002407-25cawzi0	103	27	reactive	reactive	JJ
cord-002407-25cawzi0	103	28	T	t	NN
cord-002407-25cawzi0	103	29	-	-	HYPH
cord-002407-25cawzi0	103	30	cell	cell	NN
cord-002407-25cawzi0	103	31	-	-	HYPH
cord-002407-25cawzi0	103	32	mediated	mediate	VBN
cord-002407-25cawzi0	103	33	protection	protection	NN
cord-002407-25cawzi0	103	34	against	against	IN
cord-002407-25cawzi0	103	35	heterologous	heterologous	NNP
cord-002407-25cawzi0	103	36	influenza	influenza	NN
cord-002407-25cawzi0	103	37	viruses	virus	NNS
cord-002407-25cawzi0	103	38	[	[	-LRB-
cord-002407-25cawzi0	103	39	72	72	CD
cord-002407-25cawzi0	103	40	,	,	,
cord-002407-25cawzi0	103	41	73	73	CD
cord-002407-25cawzi0	103	42	]	]	-RRB-
cord-002407-25cawzi0	103	43	.	.	.
cord-002407-25cawzi0	104	1	Although	although	IN
cord-002407-25cawzi0	104	2	both	both	DT
cord-002407-25cawzi0	104	3	IIV	IIV	NNP
cord-002407-25cawzi0	104	4	and	and	CC
cord-002407-25cawzi0	104	5	LAIV	LAIV	NNP
cord-002407-25cawzi0	104	6	have	have	VBP
cord-002407-25cawzi0	104	7	been	be	VBN
cord-002407-25cawzi0	104	8	shown	show	VBN
cord-002407-25cawzi0	104	9	to	to	TO
cord-002407-25cawzi0	104	10	be	be	VB
cord-002407-25cawzi0	104	11	efficient	efficient	JJ
cord-002407-25cawzi0	104	12	for	for	IN
cord-002407-25cawzi0	104	13	the	the	DT
cord-002407-25cawzi0	104	14	treatment	treatment	NN
cord-002407-25cawzi0	104	15	of	of	IN
cord-002407-25cawzi0	104	16	influenza	influenza	NN
cord-002407-25cawzi0	104	17	viral	viral	JJ
cord-002407-25cawzi0	104	18	infections	infection	NNS
cord-002407-25cawzi0	104	19	,	,	,
cord-002407-25cawzi0	104	20	there	there	EX
cord-002407-25cawzi0	104	21	is	be	VBZ
cord-002407-25cawzi0	104	22	an	an	DT
cord-002407-25cawzi0	104	23	unmet	unmet	JJ
cord-002407-25cawzi0	104	24	need	need	NN
cord-002407-25cawzi0	104	25	to	to	TO
cord-002407-25cawzi0	104	26	increase	increase	VB
cord-002407-25cawzi0	104	27	the	the	DT
cord-002407-25cawzi0	104	28	effectiveness	effectiveness	NN
cord-002407-25cawzi0	104	29	of	of	IN
cord-002407-25cawzi0	104	30	seasonal	seasonal	JJ
cord-002407-25cawzi0	104	31	influenza	influenza	NN
cord-002407-25cawzi0	104	32	vaccines	vaccine	NNS
cord-002407-25cawzi0	104	33	.	.	.
cord-002407-25cawzi0	105	1	Likewise	likewise	RB
cord-002407-25cawzi0	105	2	,	,	,
cord-002407-25cawzi0	105	3	there	there	EX
cord-002407-25cawzi0	105	4	is	be	VBZ
cord-002407-25cawzi0	105	5	an	an	DT
cord-002407-25cawzi0	105	6	urgent	urgent	JJ
cord-002407-25cawzi0	105	7	need	need	NN
cord-002407-25cawzi0	105	8	to	to	TO
cord-002407-25cawzi0	105	9	develop	develop	VB
cord-002407-25cawzi0	105	10	effective	effective	JJ
cord-002407-25cawzi0	105	11	vaccines	vaccine	NNS
cord-002407-25cawzi0	105	12	for	for	IN
cord-002407-25cawzi0	105	13	the	the	DT
cord-002407-25cawzi0	105	14	treatment	treatment	NN
cord-002407-25cawzi0	105	15	of	of	IN
cord-002407-25cawzi0	105	16	potential	potential	JJ
cord-002407-25cawzi0	105	17	pandemic	pandemic	NN
cord-002407-25cawzi0	105	18	influenza	influenza	NN
cord-002407-25cawzi0	105	19	viruses	virus	NNS
cord-002407-25cawzi0	105	20	.	.	.
cord-002407-25cawzi0	106	1	Although	although	IN
cord-002407-25cawzi0	106	2	vaccination	vaccination	NN
cord-002407-25cawzi0	106	3	is	be	VBZ
cord-002407-25cawzi0	106	4	the	the	DT
cord-002407-25cawzi0	106	5	main	main	JJ
cord-002407-25cawzi0	106	6	method	method	NN
cord-002407-25cawzi0	106	7	to	to	TO
cord-002407-25cawzi0	106	8	prevent	prevent	VB
cord-002407-25cawzi0	106	9	influenza	influenza	NN
cord-002407-25cawzi0	106	10	infections	infection	NNS
cord-002407-25cawzi0	106	11	in	in	IN
cord-002407-25cawzi0	106	12	humans	human	NNS
cord-002407-25cawzi0	106	13	,	,	,
cord-002407-25cawzi0	106	14	antivirals	antiviral	NNS
cord-002407-25cawzi0	106	15	offer	offer	VBP
cord-002407-25cawzi0	106	16	an	an	DT
cord-002407-25cawzi0	106	17	additional	additional	JJ
cord-002407-25cawzi0	106	18	countermeasure	countermeasure	NN
cord-002407-25cawzi0	106	19	against	against	IN
cord-002407-25cawzi0	106	20	new	new	JJ
cord-002407-25cawzi0	106	21	rapidly	rapidly	RB
cord-002407-25cawzi0	106	22	-	-	HYPH
cord-002407-25cawzi0	106	23	spreading	spread	VBG
cord-002407-25cawzi0	106	24	and/or	and/or	CC
cord-002407-25cawzi0	106	25	potentially	potentially	RB
cord-002407-25cawzi0	106	26	pandemic	pandemic	JJ
cord-002407-25cawzi0	106	27	influenza	influenza	NN
cord-002407-25cawzi0	106	28	viruses	virus	NNS
cord-002407-25cawzi0	106	29	[	[	-LRB-
cord-002407-25cawzi0	106	30	74	74	CD
cord-002407-25cawzi0	106	31	]	]	-RRB-
cord-002407-25cawzi0	106	32	[	[	-LRB-
cord-002407-25cawzi0	106	33	75	75	CD
cord-002407-25cawzi0	106	34	]	]	-RRB-
cord-002407-25cawzi0	106	35	[	[	-LRB-
cord-002407-25cawzi0	106	36	76	76	CD
cord-002407-25cawzi0	106	37	]	]	-RRB-
cord-002407-25cawzi0	106	38	.	.	.
cord-002407-25cawzi0	107	1	Therapeutic	therapeutic	JJ
cord-002407-25cawzi0	107	2	choices	choice	NNS
cord-002407-25cawzi0	107	3	to	to	TO
cord-002407-25cawzi0	107	4	control	control	VB
cord-002407-25cawzi0	107	5	influenza	influenza	NN
cord-002407-25cawzi0	107	6	infection	infection	NN
cord-002407-25cawzi0	107	7	are	be	VBP
cord-002407-25cawzi0	107	8	currently	currently	RB
cord-002407-25cawzi0	107	9	limited	limit	VBN
cord-002407-25cawzi0	107	10	to	to	IN
cord-002407-25cawzi0	107	11	two	two	CD
cord-002407-25cawzi0	107	12	classes	class	NNS
cord-002407-25cawzi0	107	13	of	of	IN
cord-002407-25cawzi0	107	14	FDA	FDA	NNP
cord-002407-25cawzi0	107	15	-	-	HYPH
cord-002407-25cawzi0	107	16	approved	approve	VBN
cord-002407-25cawzi0	107	17	antivirals	antiviral	NNS
cord-002407-25cawzi0	107	18	targeting	target	VBG
cord-002407-25cawzi0	107	19	either	either	CC
cord-002407-25cawzi0	107	20	the	the	DT
cord-002407-25cawzi0	107	21	viral	viral	JJ
cord-002407-25cawzi0	107	22	M2	M2	NNP
cord-002407-25cawzi0	107	23	ion	ion	NN
cord-002407-25cawzi0	107	24	channel	channel	NN
cord-002407-25cawzi0	107	25	(	(	-LRB-
cord-002407-25cawzi0	107	26	amantadine	amantadine	NNP
cord-002407-25cawzi0	107	27	,	,	,
cord-002407-25cawzi0	107	28	rimantadine	rimantadine	NNP
cord-002407-25cawzi0	107	29	)	)	-RRB-
cord-002407-25cawzi0	107	30	[	[	-LRB-
cord-002407-25cawzi0	107	31	77	77	CD
cord-002407-25cawzi0	107	32	]	]	-RRB-
cord-002407-25cawzi0	107	33	[	[	-LRB-
cord-002407-25cawzi0	107	34	78	78	CD
cord-002407-25cawzi0	107	35	]	]	-RRB-
cord-002407-25cawzi0	107	36	[	[	-LRB-
cord-002407-25cawzi0	107	37	79	79	CD
cord-002407-25cawzi0	107	38	]	]	-RRB-
cord-002407-25cawzi0	107	39	or	or	CC
cord-002407-25cawzi0	107	40	the	the	DT
cord-002407-25cawzi0	107	41	sialidase	sialidase	NN
cord-002407-25cawzi0	107	42	active	active	JJ
cord-002407-25cawzi0	107	43	site	site	NN
cord-002407-25cawzi0	107	44	of	of	IN
cord-002407-25cawzi0	107	45	NA	NA	NNP
cord-002407-25cawzi0	107	46	(	(	-LRB-
cord-002407-25cawzi0	107	47	oseltamivir	oseltamivir	NNP
cord-002407-25cawzi0	107	48	,	,	,
cord-002407-25cawzi0	107	49	zanamivir	zanamivir	NNP
cord-002407-25cawzi0	107	50	)	)	-RRB-
cord-002407-25cawzi0	107	51	[	[	-LRB-
cord-002407-25cawzi0	107	52	80	80	CD
cord-002407-25cawzi0	107	53	]	]	-RRB-
cord-002407-25cawzi0	107	54	.	.	.
cord-002407-25cawzi0	108	1	The	the	DT
cord-002407-25cawzi0	108	2	first	first	JJ
cord-002407-25cawzi0	108	3	inhibits	inhibit	VBZ
cord-002407-25cawzi0	108	4	the	the	DT
cord-002407-25cawzi0	108	5	initial	initial	JJ
cord-002407-25cawzi0	108	6	steps	step	NNS
cord-002407-25cawzi0	108	7	of	of	IN
cord-002407-25cawzi0	108	8	the	the	DT
cord-002407-25cawzi0	108	9	virus	virus	NN
cord-002407-25cawzi0	108	10	life	life	NN
cord-002407-25cawzi0	108	11	cycle	cycle	NN
cord-002407-25cawzi0	108	12	,	,	,
cord-002407-25cawzi0	108	13	while	while	IN
cord-002407-25cawzi0	108	14	the	the	DT
cord-002407-25cawzi0	108	15	second	second	JJ
cord-002407-25cawzi0	108	16	inhibits	inhibit	VBZ
cord-002407-25cawzi0	108	17	virus	virus	NN
cord-002407-25cawzi0	108	18	release	release	NN
cord-002407-25cawzi0	108	19	.	.	.
cord-002407-25cawzi0	109	1	However	however	RB
cord-002407-25cawzi0	109	2	,	,	,
cord-002407-25cawzi0	109	3	NA	NA	NNP
cord-002407-25cawzi0	109	4	inhibitors	inhibitor	NNS
cord-002407-25cawzi0	109	5	are	be	VBP
cord-002407-25cawzi0	109	6	the	the	DT
cord-002407-25cawzi0	109	7	only	only	JJ
cord-002407-25cawzi0	109	8	type	type	NN
cord-002407-25cawzi0	109	9	of	of	IN
cord-002407-25cawzi0	109	10	antivirals	antiviral	NNS
cord-002407-25cawzi0	109	11	approved	approve	VBN
cord-002407-25cawzi0	109	12	for	for	IN
cord-002407-25cawzi0	109	13	the	the	DT
cord-002407-25cawzi0	109	14	prophylaxis	prophylaxis	NN
cord-002407-25cawzi0	109	15	and	and	CC
cord-002407-25cawzi0	109	16	treatment	treatment	NN
cord-002407-25cawzi0	109	17	of	of	IN
cord-002407-25cawzi0	109	18	IBV	IBV	NNP
cord-002407-25cawzi0	109	19	infections	infection	NNS
cord-002407-25cawzi0	109	20	[	[	-LRB-
cord-002407-25cawzi0	109	21	81	81	CD
cord-002407-25cawzi0	109	22	]	]	-RRB-
cord-002407-25cawzi0	109	23	,	,	,
cord-002407-25cawzi0	109	24	although	although	IN
cord-002407-25cawzi0	109	25	data	datum	NNS
cord-002407-25cawzi0	109	26	from	from	IN
cord-002407-25cawzi0	109	27	clinical	clinical	JJ
cord-002407-25cawzi0	109	28	trials	trial	NNS
cord-002407-25cawzi0	109	29	have	have	VBP
cord-002407-25cawzi0	109	30	shown	show	VBN
cord-002407-25cawzi0	109	31	that	that	IN
cord-002407-25cawzi0	109	32	oseltamivir	oseltamivir	NNP
cord-002407-25cawzi0	109	33	is	be	VBZ
cord-002407-25cawzi0	109	34	less	less	RBR
cord-002407-25cawzi0	109	35	effective	effective	JJ
cord-002407-25cawzi0	109	36	against	against	IN
cord-002407-25cawzi0	109	37	IBVs	ibv	NNS
cord-002407-25cawzi0	109	38	than	than	IN
cord-002407-25cawzi0	109	39	against	against	IN
cord-002407-25cawzi0	109	40	IAVs	iav	NNS
cord-002407-25cawzi0	109	41	[	[	-LRB-
cord-002407-25cawzi0	109	42	82	82	CD
cord-002407-25cawzi0	109	43	]	]	-RRB-
cord-002407-25cawzi0	109	44	.	.	.
cord-002407-25cawzi0	110	1	Importantly	importantly	RB
cord-002407-25cawzi0	110	2	,	,	,
cord-002407-25cawzi0	110	3	mutations	mutation	NNS
cord-002407-25cawzi0	110	4	in	in	IN
cord-002407-25cawzi0	110	5	the	the	DT
cord-002407-25cawzi0	110	6	viral	viral	JJ
cord-002407-25cawzi0	110	7	genome	genome	NN
cord-002407-25cawzi0	110	8	can	can	MD
cord-002407-25cawzi0	110	9	lead	lead	VB
cord-002407-25cawzi0	110	10	to	to	IN
cord-002407-25cawzi0	110	11	influenza	influenza	NN
cord-002407-25cawzi0	110	12	antivirals	antiviral	NNS
cord-002407-25cawzi0	110	13	being	be	VBG
cord-002407-25cawzi0	110	14	ineffective	ineffective	JJ
cord-002407-25cawzi0	110	15	,	,	,
cord-002407-25cawzi0	110	16	like	like	UH
cord-002407-25cawzi0	110	17	in	in	IN
cord-002407-25cawzi0	110	18	the	the	DT
cord-002407-25cawzi0	110	19	case	case	NN
cord-002407-25cawzi0	110	20	of	of	IN
cord-002407-25cawzi0	110	21	M2	M2	NNP
cord-002407-25cawzi0	110	22	blockers	blocker	NNS
cord-002407-25cawzi0	110	23	,	,	,
cord-002407-25cawzi0	110	24	which	which	WDT
cord-002407-25cawzi0	110	25	are	be	VBP
cord-002407-25cawzi0	110	26	no	no	RB
cord-002407-25cawzi0	110	27	longer	long	RBR
cord-002407-25cawzi0	110	28	recommended	recommend	VBN
cord-002407-25cawzi0	110	29	against	against	IN
cord-002407-25cawzi0	110	30	circulating	circulate	VBG
cord-002407-25cawzi0	110	31	seasonal	seasonal	JJ
cord-002407-25cawzi0	110	32	influenza	influenza	NN
cord-002407-25cawzi0	110	33	viral	viral	JJ
cord-002407-25cawzi0	110	34	strains	strain	NNS
cord-002407-25cawzi0	110	35	[	[	-LRB-
cord-002407-25cawzi0	110	36	83	83	CD
cord-002407-25cawzi0	110	37	]	]	-RRB-
cord-002407-25cawzi0	110	38	.	.	.
cord-002407-25cawzi0	111	1	Therefore	therefore	RB
cord-002407-25cawzi0	111	2	,	,	,
cord-002407-25cawzi0	111	3	the	the	DT
cord-002407-25cawzi0	111	4	emergence	emergence	NN
cord-002407-25cawzi0	111	5	of	of	IN
cord-002407-25cawzi0	111	6	drug	drug	NN
cord-002407-25cawzi0	111	7	-	-	HYPH
cord-002407-25cawzi0	111	8	resistant	resistant	JJ
cord-002407-25cawzi0	111	9	influenza	influenza	NN
cord-002407-25cawzi0	111	10	variants	variant	NNS
cord-002407-25cawzi0	111	11	is	be	VBZ
cord-002407-25cawzi0	111	12	an	an	DT
cord-002407-25cawzi0	111	13	increasing	increase	VBG
cord-002407-25cawzi0	111	14	concern	concern	NN
cord-002407-25cawzi0	111	15	for	for	IN
cord-002407-25cawzi0	111	16	controlling	control	VBG
cord-002407-25cawzi0	111	17	influenza	influenza	NN
cord-002407-25cawzi0	111	18	infections	infection	NNS
cord-002407-25cawzi0	111	19	[	[	-LRB-
cord-002407-25cawzi0	111	20	76	76	CD
cord-002407-25cawzi0	111	21	,	,	,
cord-002407-25cawzi0	111	22	84	84	CD
cord-002407-25cawzi0	111	23	]	]	-RRB-
cord-002407-25cawzi0	111	24	,	,	,
cord-002407-25cawzi0	111	25	and	and	CC
cord-002407-25cawzi0	111	26	there	there	EX
cord-002407-25cawzi0	111	27	is	be	VBZ
cord-002407-25cawzi0	111	28	a	a	DT
cord-002407-25cawzi0	111	29	significant	significant	JJ
cord-002407-25cawzi0	111	30	need	need	NN
cord-002407-25cawzi0	111	31	for	for	IN
cord-002407-25cawzi0	111	32	the	the	DT
cord-002407-25cawzi0	111	33	identification	identification	NN
cord-002407-25cawzi0	111	34	of	of	IN
cord-002407-25cawzi0	111	35	novel	novel	JJ
cord-002407-25cawzi0	111	36	compounds	compound	NNS
cord-002407-25cawzi0	111	37	with	with	IN
cord-002407-25cawzi0	111	38	antivirals	antiviral	NNS
cord-002407-25cawzi0	111	39	properties	property	NNS
cord-002407-25cawzi0	111	40	.	.	.
cord-002407-25cawzi0	112	1	Influenza	influenza	NN
cord-002407-25cawzi0	112	2	viruses	virus	NNS
cord-002407-25cawzi0	112	3	evade	evade	VBP
cord-002407-25cawzi0	112	4	human	human	JJ
cord-002407-25cawzi0	112	5	pre	pre	JJ
cord-002407-25cawzi0	112	6	-	-	JJ
cord-002407-25cawzi0	112	7	existing	existing	JJ
cord-002407-25cawzi0	112	8	immunity	immunity	NN
cord-002407-25cawzi0	112	9	by	by	IN
cord-002407-25cawzi0	112	10	accumulating	accumulate	VBG
cord-002407-25cawzi0	112	11	mutations	mutation	NNS
cord-002407-25cawzi0	112	12	(	(	-LRB-
cord-002407-25cawzi0	112	13	antigenic	antigenic	JJ
cord-002407-25cawzi0	112	14	drift	drift	NN
cord-002407-25cawzi0	112	15	)	)	-RRB-
cord-002407-25cawzi0	112	16	,	,	,
cord-002407-25cawzi0	112	17	allowing	allow	VBG
cord-002407-25cawzi0	112	18	reinfection	reinfection	NN
cord-002407-25cawzi0	112	19	of	of	IN
cord-002407-25cawzi0	112	20	individuals	individual	NNS
cord-002407-25cawzi0	112	21	previously	previously	RB
cord-002407-25cawzi0	112	22	exposed	expose	VBN
cord-002407-25cawzi0	112	23	to	to	IN
cord-002407-25cawzi0	112	24	natural	natural	JJ
cord-002407-25cawzi0	112	25	infections	infection	NNS
cord-002407-25cawzi0	112	26	or	or	CC
cord-002407-25cawzi0	112	27	vaccinated	vaccinate	VBN
cord-002407-25cawzi0	112	28	.	.	.
cord-002407-25cawzi0	113	1	Thus	thus	RB
cord-002407-25cawzi0	113	2	,	,	,
cord-002407-25cawzi0	113	3	vaccine	vaccine	NN
cord-002407-25cawzi0	113	4	companies	company	NNS
cord-002407-25cawzi0	113	5	have	have	VBP
cord-002407-25cawzi0	113	6	to	to	TO
cord-002407-25cawzi0	113	7	reformulate	reformulate	VB
cord-002407-25cawzi0	113	8	the	the	DT
cord-002407-25cawzi0	113	9	composition	composition	NN
cord-002407-25cawzi0	113	10	of	of	IN
cord-002407-25cawzi0	113	11	influenza	influenza	NN
cord-002407-25cawzi0	113	12	vaccines	vaccine	NNS
cord-002407-25cawzi0	113	13	yearly	yearly	JJ
cord-002407-25cawzi0	113	14	to	to	TO
cord-002407-25cawzi0	113	15	ensure	ensure	VB
cord-002407-25cawzi0	113	16	a	a	DT
cord-002407-25cawzi0	113	17	good	good	JJ
cord-002407-25cawzi0	113	18	match	match	NN
cord-002407-25cawzi0	113	19	between	between	IN
cord-002407-25cawzi0	113	20	the	the	DT
cord-002407-25cawzi0	113	21	viruses	virus	NNS
cord-002407-25cawzi0	113	22	present	present	JJ
cord-002407-25cawzi0	113	23	in	in	IN
cord-002407-25cawzi0	113	24	the	the	DT
cord-002407-25cawzi0	113	25	vaccine	vaccine	NN
cord-002407-25cawzi0	113	26	and	and	CC
cord-002407-25cawzi0	113	27	those	those	DT
cord-002407-25cawzi0	113	28	seasonally	seasonally	RB
cord-002407-25cawzi0	113	29	circulating	circulate	VBG
cord-002407-25cawzi0	113	30	in	in	IN
cord-002407-25cawzi0	113	31	humans	human	NNS
cord-002407-25cawzi0	113	32	[	[	-LRB-
cord-002407-25cawzi0	113	33	33	33	CD
cord-002407-25cawzi0	113	34	,	,	,
cord-002407-25cawzi0	113	35	34	34	CD
cord-002407-25cawzi0	113	36	,	,	,
cord-002407-25cawzi0	113	37	85	85	CD
cord-002407-25cawzi0	113	38	]	]	-RRB-
cord-002407-25cawzi0	113	39	.	.	.
cord-002407-25cawzi0	114	1	The	the	DT
cord-002407-25cawzi0	114	2	WHO	WHO	NNP
cord-002407-25cawzi0	114	3	Global	Global	NNP
cord-002407-25cawzi0	114	4	Influenza	Influenza	NNP
cord-002407-25cawzi0	114	5	Surveillance	Surveillance	NNP
cord-002407-25cawzi0	114	6	Network	Network	NNP
cord-002407-25cawzi0	114	7	(	(	-LRB-
cord-002407-25cawzi0	114	8	GISN	GISN	NNP
cord-002407-25cawzi0	114	9	)	)	-RRB-
cord-002407-25cawzi0	114	10	[	[	-LRB-
cord-002407-25cawzi0	114	11	35	35	CD
cord-002407-25cawzi0	114	12	]	]	-RRB-
cord-002407-25cawzi0	114	13	,	,	,
cord-002407-25cawzi0	114	14	which	which	WDT
cord-002407-25cawzi0	114	15	includes	include	VBZ
cord-002407-25cawzi0	114	16	more	more	JJR
cord-002407-25cawzi0	114	17	than	than	IN
cord-002407-25cawzi0	114	18	120	120	CD
cord-002407-25cawzi0	114	19	National	National	NNP
cord-002407-25cawzi0	114	20	Influenza	Influenza	NNP
cord-002407-25cawzi0	114	21	Centers	Centers	NNPS
cord-002407-25cawzi0	114	22	in	in	IN
cord-002407-25cawzi0	114	23	over	over	IN
cord-002407-25cawzi0	114	24	90	90	CD
cord-002407-25cawzi0	114	25	countries	country	NNS
cord-002407-25cawzi0	114	26	[	[	-LRB-
cord-002407-25cawzi0	114	27	86	86	CD
cord-002407-25cawzi0	114	28	]	]	-RRB-
cord-002407-25cawzi0	114	29	,	,	,
cord-002407-25cawzi0	114	30	tracks	track	VBZ
cord-002407-25cawzi0	114	31	the	the	DT
cord-002407-25cawzi0	114	32	evolution	evolution	NN
cord-002407-25cawzi0	114	33	and	and	CC
cord-002407-25cawzi0	114	34	epidemiology	epidemiology	NN
cord-002407-25cawzi0	114	35	of	of	IN
cord-002407-25cawzi0	114	36	influenza	influenza	NN
cord-002407-25cawzi0	114	37	viruses	virus	NNS
cord-002407-25cawzi0	114	38	and	and	CC
cord-002407-25cawzi0	114	39	uses	use	VBZ
cord-002407-25cawzi0	114	40	the	the	DT
cord-002407-25cawzi0	114	41	collected	collect	VBN
cord-002407-25cawzi0	114	42	data	datum	NNS
cord-002407-25cawzi0	114	43	for	for	IN
cord-002407-25cawzi0	114	44	the	the	DT
cord-002407-25cawzi0	114	45	vaccine	vaccine	NN
cord-002407-25cawzi0	114	46	strain	strain	NN
cord-002407-25cawzi0	114	47	selection	selection	NN
cord-002407-25cawzi0	114	48	process	process	NN
cord-002407-25cawzi0	114	49	.	.	.
cord-002407-25cawzi0	115	1	These	these	DT
cord-002407-25cawzi0	115	2	studies	study	NNS
cord-002407-25cawzi0	115	3	also	also	RB
cord-002407-25cawzi0	115	4	help	help	VBP
cord-002407-25cawzi0	115	5	to	to	TO
cord-002407-25cawzi0	115	6	understand	understand	VB
cord-002407-25cawzi0	115	7	virus	virus	NN
cord-002407-25cawzi0	115	8	evolution	evolution	NN
cord-002407-25cawzi0	115	9	and	and	CC
cord-002407-25cawzi0	115	10	epidemiology	epidemiology	NN
cord-002407-25cawzi0	115	11	in	in	IN
cord-002407-25cawzi0	115	12	different	different	JJ
cord-002407-25cawzi0	115	13	geographic	geographic	JJ
cord-002407-25cawzi0	115	14	areas	area	NNS
cord-002407-25cawzi0	115	15	[	[	-LRB-
cord-002407-25cawzi0	115	16	19	19	CD
cord-002407-25cawzi0	115	17	]	]	-RRB-
cord-002407-25cawzi0	115	18	.	.	.
cord-002407-25cawzi0	116	1	(	(	-LRB-
cord-002407-25cawzi0	116	2	4	4	LS
cord-002407-25cawzi0	116	3	)	)	-RRB-
cord-002407-25cawzi0	117	1	The	the	DT
cord-002407-25cawzi0	117	2	National	National	NNP
cord-002407-25cawzi0	117	3	Institute	Institute	NNP
cord-002407-25cawzi0	117	4	of	of	IN
cord-002407-25cawzi0	117	5	Infectious	Infectious	NNP
cord-002407-25cawzi0	117	6	Disease	Disease	NNP
cord-002407-25cawzi0	117	7	in	in	IN
cord-002407-25cawzi0	117	8	Tokyo	Tokyo	NNP
cord-002407-25cawzi0	117	9	,	,	,
cord-002407-25cawzi0	117	10	Japan	Japan	NNP
cord-002407-25cawzi0	117	11	.	.	.
cord-002407-25cawzi0	118	1	Basically	basically	RB
cord-002407-25cawzi0	118	2	,	,	,
cord-002407-25cawzi0	118	3	the	the	DT
cord-002407-25cawzi0	118	4	degree	degree	NN
cord-002407-25cawzi0	118	5	of	of	IN
cord-002407-25cawzi0	118	6	immunity	immunity	NN
cord-002407-25cawzi0	118	7	induced	induce	VBN
cord-002407-25cawzi0	118	8	by	by	IN
cord-002407-25cawzi0	118	9	one	one	CD
cord-002407-25cawzi0	118	10	influenza	influenza	NN
cord-002407-25cawzi0	118	11	strain	strain	NN
cord-002407-25cawzi0	118	12	that	that	WDT
cord-002407-25cawzi0	118	13	is	be	VBZ
cord-002407-25cawzi0	118	14	effective	effective	JJ
cord-002407-25cawzi0	118	15	against	against	IN
cord-002407-25cawzi0	118	16	another	another	DT
cord-002407-25cawzi0	118	17	strain	strain	NN
cord-002407-25cawzi0	118	18	is	be	VBZ
cord-002407-25cawzi0	118	19	mainly	mainly	RB
cord-002407-25cawzi0	118	20	dependent	dependent	JJ
cord-002407-25cawzi0	118	21	on	on	IN
cord-002407-25cawzi0	118	22	the	the	DT
cord-002407-25cawzi0	118	23	antigenic	antigenic	JJ
cord-002407-25cawzi0	118	24	difference	difference	NN
cord-002407-25cawzi0	118	25	between	between	IN
cord-002407-25cawzi0	118	26	both	both	DT
cord-002407-25cawzi0	118	27	viral	viral	JJ
cord-002407-25cawzi0	118	28	strains	strain	NNS
cord-002407-25cawzi0	118	29	[	[	-LRB-
cord-002407-25cawzi0	118	30	87	87	CD
cord-002407-25cawzi0	118	31	,	,	,
cord-002407-25cawzi0	118	32	88	88	CD
cord-002407-25cawzi0	118	33	]	]	-RRB-
cord-002407-25cawzi0	118	34	.	.	.
cord-002407-25cawzi0	119	1	The	the	DT
cord-002407-25cawzi0	119	2	influenza	influenza	NN
cord-002407-25cawzi0	119	3	viral	viral	JJ
cord-002407-25cawzi0	119	4	glycoprotein	glycoprotein	NN
cord-002407-25cawzi0	119	5	HA	HA	NNP
cord-002407-25cawzi0	119	6	,	,	,
cord-002407-25cawzi0	119	7	the	the	DT
cord-002407-25cawzi0	119	8	primary	primary	JJ
cord-002407-25cawzi0	119	9	target	target	NN
cord-002407-25cawzi0	119	10	of	of	IN
cord-002407-25cawzi0	119	11	the	the	DT
cord-002407-25cawzi0	119	12	protective	protective	JJ
cord-002407-25cawzi0	119	13	neutralizing	neutralize	VBG
cord-002407-25cawzi0	119	14	immune	immune	JJ
cord-002407-25cawzi0	119	15	responses	response	NNS
cord-002407-25cawzi0	119	16	[	[	-LRB-
cord-002407-25cawzi0	119	17	88	88	CD
cord-002407-25cawzi0	119	18	,	,	,
cord-002407-25cawzi0	119	19	89	89	CD
cord-002407-25cawzi0	119	20	]	]	-RRB-
cord-002407-25cawzi0	119	21	,	,	,
cord-002407-25cawzi0	119	22	is	be	VBZ
cord-002407-25cawzi0	119	23	the	the	DT
cord-002407-25cawzi0	119	24	focus	focus	NN
cord-002407-25cawzi0	119	25	of	of	IN
cord-002407-25cawzi0	119	26	influenza	influenza	NN
cord-002407-25cawzi0	119	27	virus	virus	NN
cord-002407-25cawzi0	119	28	surveillance	surveillance	NN
cord-002407-25cawzi0	119	29	and	and	CC
cord-002407-25cawzi0	119	30	the	the	DT
cord-002407-25cawzi0	119	31	primary	primary	JJ
cord-002407-25cawzi0	119	32	component	component	NN
cord-002407-25cawzi0	119	33	targeted	target	VBN
cord-002407-25cawzi0	119	34	by	by	IN
cord-002407-25cawzi0	119	35	currently	currently	RB
cord-002407-25cawzi0	119	36	licensed	license	VBN
cord-002407-25cawzi0	119	37	influenza	influenza	NN
cord-002407-25cawzi0	119	38	vaccines	vaccine	NNS
cord-002407-25cawzi0	119	39	[	[	-LRB-
cord-002407-25cawzi0	119	40	72	72	CD
cord-002407-25cawzi0	119	41	,	,	,
cord-002407-25cawzi0	119	42	89	89	CD
cord-002407-25cawzi0	119	43	]	]	-RRB-
cord-002407-25cawzi0	119	44	.	.	.
cord-002407-25cawzi0	120	1	Influenza	influenza	NN
cord-002407-25cawzi0	120	2	vaccine	vaccine	NN
cord-002407-25cawzi0	120	3	production	production	NN
cord-002407-25cawzi0	120	4	is	be	VBZ
cord-002407-25cawzi0	120	5	challenging	challenging	JJ
cord-002407-25cawzi0	120	6	because	because	IN
cord-002407-25cawzi0	120	7	of	of	IN
cord-002407-25cawzi0	120	8	the	the	DT
cord-002407-25cawzi0	120	9	wait	wait	NN
cord-002407-25cawzi0	120	10	time	time	NN
cord-002407-25cawzi0	120	11	that	that	WDT
cord-002407-25cawzi0	120	12	is	be	VBZ
cord-002407-25cawzi0	120	13	needed	need	VBN
cord-002407-25cawzi0	120	14	to	to	TO
cord-002407-25cawzi0	120	15	identify	identify	VB
cord-002407-25cawzi0	120	16	the	the	DT
cord-002407-25cawzi0	120	17	predominant	predominant	JJ
cord-002407-25cawzi0	120	18	circulating	circulate	VBG
cord-002407-25cawzi0	120	19	virus	virus	NN
cord-002407-25cawzi0	120	20	and	and	CC
cord-002407-25cawzi0	120	21	the	the	DT
cord-002407-25cawzi0	120	22	production	production	NN
cord-002407-25cawzi0	120	23	time	time	NN
cord-002407-25cawzi0	120	24	that	that	WDT
cord-002407-25cawzi0	120	25	is	be	VBZ
cord-002407-25cawzi0	120	26	needed	need	VBN
cord-002407-25cawzi0	120	27	to	to	TO
cord-002407-25cawzi0	120	28	manufacture	manufacture	VB
cord-002407-25cawzi0	120	29	the	the	DT
cord-002407-25cawzi0	120	30	vaccine	vaccine	NN
cord-002407-25cawzi0	120	31	.	.	.
cord-002407-25cawzi0	121	1	The	the	DT
cord-002407-25cawzi0	121	2	National	National	NNP
cord-002407-25cawzi0	121	3	Influenza	Influenza	NNP
cord-002407-25cawzi0	121	4	Centers	Centers	NNPS
cord-002407-25cawzi0	121	5	perform	perform	VBP
cord-002407-25cawzi0	121	6	virus	virus	NN
cord-002407-25cawzi0	121	7	isolation	isolation	NN
cord-002407-25cawzi0	121	8	on	on	IN
cord-002407-25cawzi0	121	9	certain	certain	JJ
cord-002407-25cawzi0	121	10	samples	sample	NNS
cord-002407-25cawzi0	121	11	obtained	obtain	VBN
cord-002407-25cawzi0	121	12	from	from	IN
cord-002407-25cawzi0	121	13	patients	patient	NNS
cord-002407-25cawzi0	121	14	to	to	TO
cord-002407-25cawzi0	121	15	identify	identify	VB
cord-002407-25cawzi0	121	16	circulating	circulate	VBG
cord-002407-25cawzi0	121	17	viruses	virus	NNS
cord-002407-25cawzi0	121	18	and	and	CC
cord-002407-25cawzi0	121	19	to	to	TO
cord-002407-25cawzi0	121	20	determine	determine	VB
cord-002407-25cawzi0	121	21	if	if	IN
cord-002407-25cawzi0	121	22	the	the	DT
cord-002407-25cawzi0	121	23	viruses	virus	NNS
cord-002407-25cawzi0	121	24	grow	grow	VB
cord-002407-25cawzi0	121	25	efficiently	efficiently	RB
cord-002407-25cawzi0	121	26	in	in	IN
cord-002407-25cawzi0	121	27	culture	culture	NN
cord-002407-25cawzi0	121	28	.	.	.
cord-002407-25cawzi0	122	1	Normally	normally	RB
cord-002407-25cawzi0	122	2	,	,	,
cord-002407-25cawzi0	122	3	influenza	influenza	NN
cord-002407-25cawzi0	122	4	viruses	virus	NNS
cord-002407-25cawzi0	122	5	are	be	VBP
cord-002407-25cawzi0	122	6	isolated	isolate	VBN
cord-002407-25cawzi0	122	7	using	use	VBG
cord-002407-25cawzi0	122	8	Madin	Madin	NNP
cord-002407-25cawzi0	122	9	Darby	Darby	NNP
cord-002407-25cawzi0	122	10	canine	canine	JJ
cord-002407-25cawzi0	122	11	kidney	kidney	NN
cord-002407-25cawzi0	122	12	(	(	-LRB-
cord-002407-25cawzi0	122	13	MDCK	MDCK	NNP
cord-002407-25cawzi0	122	14	)	)	-RRB-
cord-002407-25cawzi0	122	15	cells	cell	NNS
cord-002407-25cawzi0	122	16	instead	instead	RB
cord-002407-25cawzi0	122	17	of	of	IN
cord-002407-25cawzi0	122	18	chicken	chicken	NN
cord-002407-25cawzi0	122	19	embryonated	embryonate	VBN
cord-002407-25cawzi0	122	20	eggs	egg	NNS
cord-002407-25cawzi0	122	21	because	because	IN
cord-002407-25cawzi0	122	22	higher	high	JJR
cord-002407-25cawzi0	122	23	isolation	isolation	NN
cord-002407-25cawzi0	122	24	rates	rate	NNS
cord-002407-25cawzi0	122	25	,	,	,
cord-002407-25cawzi0	122	26	especially	especially	RB
cord-002407-25cawzi0	122	27	for	for	IN
cord-002407-25cawzi0	122	28	H3N2	H3N2	NNP
cord-002407-25cawzi0	122	29	IAV	IAV	NNP
cord-002407-25cawzi0	122	30	strains	strain	NNS
cord-002407-25cawzi0	122	31	,	,	,
cord-002407-25cawzi0	122	32	have	have	VBP
cord-002407-25cawzi0	122	33	been	be	VBN
cord-002407-25cawzi0	122	34	reported	report	VBN
cord-002407-25cawzi0	122	35	using	use	VBG
cord-002407-25cawzi0	122	36	MDCK	MDCK	NNP
cord-002407-25cawzi0	122	37	cells	cell	NNS
cord-002407-25cawzi0	122	38	[	[	-LRB-
cord-002407-25cawzi0	122	39	90	90	CD
cord-002407-25cawzi0	122	40	]	]	-RRB-
cord-002407-25cawzi0	123	1	[	[	-LRB-
cord-002407-25cawzi0	123	2	91	91	CD
cord-002407-25cawzi0	123	3	]	]	-RRB-
cord-002407-25cawzi0	123	4	[	[	-LRB-
cord-002407-25cawzi0	123	5	92	92	CD
cord-002407-25cawzi0	123	6	]	]	-RRB-
cord-002407-25cawzi0	123	7	.	.	.
cord-002407-25cawzi0	124	1	Although	although	IN
cord-002407-25cawzi0	124	2	most	most	JJS
cord-002407-25cawzi0	124	3	influenza	influenza	NN
cord-002407-25cawzi0	124	4	viruses	virus	NNS
cord-002407-25cawzi0	124	5	are	be	VBP
cord-002407-25cawzi0	124	6	isolated	isolate	VBN
cord-002407-25cawzi0	124	7	from	from	IN
cord-002407-25cawzi0	124	8	mammalian	mammalian	JJ
cord-002407-25cawzi0	124	9	cells	cell	NNS
cord-002407-25cawzi0	124	10	,	,	,
cord-002407-25cawzi0	124	11	viruses	virus	NNS
cord-002407-25cawzi0	124	12	must	must	MD
cord-002407-25cawzi0	124	13	be	be	VB
cord-002407-25cawzi0	124	14	generated	generate	VBN
cord-002407-25cawzi0	124	15	in	in	IN
cord-002407-25cawzi0	124	16	embryonated	embryonate	VBN
cord-002407-25cawzi0	124	17	eggs	egg	NNS
cord-002407-25cawzi0	124	18	for	for	IN
cord-002407-25cawzi0	124	19	vaccine	vaccine	NN
cord-002407-25cawzi0	124	20	manufacturing	manufacturing	NN
cord-002407-25cawzi0	124	21	due	due	IN
cord-002407-25cawzi0	124	22	to	to	IN
cord-002407-25cawzi0	124	23	regulations	regulation	NNS
cord-002407-25cawzi0	124	24	[	[	-LRB-
cord-002407-25cawzi0	124	25	93	93	CD
cord-002407-25cawzi0	124	26	]	]	-RRB-
cord-002407-25cawzi0	124	27	.	.	.
cord-002407-25cawzi0	125	1	Nowadays	nowadays	RB
cord-002407-25cawzi0	125	2	,	,	,
cord-002407-25cawzi0	125	3	the	the	DT
cord-002407-25cawzi0	125	4	vaccine	vaccine	NN
cord-002407-25cawzi0	125	5	strains	strain	NNS
cord-002407-25cawzi0	125	6	must	must	MD
cord-002407-25cawzi0	125	7	be	be	VB
cord-002407-25cawzi0	125	8	selected	select	VBN
cord-002407-25cawzi0	125	9	almost	almost	RB
cord-002407-25cawzi0	125	10	7	7	CD
cord-002407-25cawzi0	125	11	-	-	SYM
cord-002407-25cawzi0	125	12	9	9	CD
cord-002407-25cawzi0	125	13	months	month	NNS
cord-002407-25cawzi0	125	14	ahead	ahead	RB
cord-002407-25cawzi0	125	15	of	of	IN
cord-002407-25cawzi0	125	16	the	the	DT
cord-002407-25cawzi0	125	17	influenza	influenza	NN
cord-002407-25cawzi0	125	18	season	season	NN
cord-002407-25cawzi0	125	19	in	in	IN
cord-002407-25cawzi0	125	20	which	which	WDT
cord-002407-25cawzi0	125	21	they	-PRON-	PRP
cord-002407-25cawzi0	125	22	will	will	MD
cord-002407-25cawzi0	125	23	be	be	VB
cord-002407-25cawzi0	125	24	used	use	VBN
cord-002407-25cawzi0	125	25	.	.	.
cord-002407-25cawzi0	126	1	The	the	DT
cord-002407-25cawzi0	126	2	recommendation	recommendation	NN
cord-002407-25cawzi0	126	3	for	for	IN
cord-002407-25cawzi0	126	4	the	the	DT
cord-002407-25cawzi0	126	5	strains	strain	NNS
cord-002407-25cawzi0	126	6	included	include	VBN
cord-002407-25cawzi0	126	7	in	in	IN
cord-002407-25cawzi0	126	8	the	the	DT
cord-002407-25cawzi0	126	9	vaccine	vaccine	NN
cord-002407-25cawzi0	126	10	composition	composition	NN
cord-002407-25cawzi0	126	11	for	for	IN
cord-002407-25cawzi0	126	12	the	the	DT
cord-002407-25cawzi0	126	13	Northern	Northern	NNP
cord-002407-25cawzi0	126	14	Hemisphere	Hemisphere	NNP
cord-002407-25cawzi0	126	15	is	be	VBZ
cord-002407-25cawzi0	126	16	made	make	VBN
cord-002407-25cawzi0	126	17	in	in	IN
cord-002407-25cawzi0	126	18	February	February	NNP
cord-002407-25cawzi0	126	19	to	to	TO
cord-002407-25cawzi0	126	20	allow	allow	VB
cord-002407-25cawzi0	126	21	time	time	NN
cord-002407-25cawzi0	126	22	for	for	IN
cord-002407-25cawzi0	126	23	the~300	the~300	NNP
cord-002407-25cawzi0	126	24	million	million	CD
cord-002407-25cawzi0	126	25	doses	dose	NNS
cord-002407-25cawzi0	126	26	of	of	IN
cord-002407-25cawzi0	126	27	vaccine	vaccine	NN
cord-002407-25cawzi0	126	28	to	to	TO
cord-002407-25cawzi0	126	29	be	be	VB
cord-002407-25cawzi0	126	30	produced	produce	VBN
cord-002407-25cawzi0	126	31	in	in	IN
cord-002407-25cawzi0	126	32	time	time	NN
cord-002407-25cawzi0	126	33	for	for	IN
cord-002407-25cawzi0	126	34	vaccinating	vaccinate	VBG
cord-002407-25cawzi0	126	35	people	people	NNS
cord-002407-25cawzi0	126	36	in	in	IN
cord-002407-25cawzi0	126	37	October	October	NNP
cord-002407-25cawzi0	126	38	/	/	SYM
cord-002407-25cawzi0	126	39	November	November	NNP
cord-002407-25cawzi0	126	40	.	.	.
cord-002407-25cawzi0	127	1	This	this	DT
cord-002407-25cawzi0	127	2	allows	allow	VBZ
cord-002407-25cawzi0	127	3	for	for	IN
cord-002407-25cawzi0	127	4	influenza	influenza	NN
cord-002407-25cawzi0	127	5	season	season	NN
cord-002407-25cawzi0	127	6	preparation	preparation	NN
cord-002407-25cawzi0	127	7	,	,	,
cord-002407-25cawzi0	127	8	which	which	WDT
cord-002407-25cawzi0	127	9	typically	typically	RB
cord-002407-25cawzi0	127	10	peaks	peak	VBZ
cord-002407-25cawzi0	127	11	sometime	sometime	RB
cord-002407-25cawzi0	127	12	between	between	IN
cord-002407-25cawzi0	127	13	December	December	NNP
cord-002407-25cawzi0	127	14	and	and	CC
cord-002407-25cawzi0	127	15	March	March	NNP
cord-002407-25cawzi0	127	16	[	[	-LRB-
cord-002407-25cawzi0	127	17	86	86	CD
cord-002407-25cawzi0	127	18	]	]	-RRB-
cord-002407-25cawzi0	127	19	.	.	.
cord-002407-25cawzi0	128	1	On	on	IN
cord-002407-25cawzi0	128	2	the	the	DT
cord-002407-25cawzi0	128	3	other	other	JJ
cord-002407-25cawzi0	128	4	hand	hand	NN
cord-002407-25cawzi0	128	5	,	,	,
cord-002407-25cawzi0	128	6	for	for	IN
cord-002407-25cawzi0	128	7	the	the	DT
cord-002407-25cawzi0	128	8	Southern	Southern	NNP
cord-002407-25cawzi0	128	9	Hemisphere	Hemisphere	NNP
cord-002407-25cawzi0	128	10	,	,	,
cord-002407-25cawzi0	128	11	recommendations	recommendation	NNS
cord-002407-25cawzi0	128	12	are	be	VBP
cord-002407-25cawzi0	128	13	provided	provide	VBN
cord-002407-25cawzi0	128	14	in	in	IN
cord-002407-25cawzi0	128	15	September	September	NNP
cord-002407-25cawzi0	128	16	,	,	,
cord-002407-25cawzi0	128	17	and	and	CC
cord-002407-25cawzi0	128	18	vaccination	vaccination	NN
cord-002407-25cawzi0	128	19	takes	take	VBZ
cord-002407-25cawzi0	128	20	place	place	NN
cord-002407-25cawzi0	128	21	in	in	IN
cord-002407-25cawzi0	128	22	March	March	NNP
cord-002407-25cawzi0	128	23	/	/	SYM
cord-002407-25cawzi0	128	24	April	April	NNP
cord-002407-25cawzi0	128	25	of	of	IN
cord-002407-25cawzi0	128	26	the	the	DT
cord-002407-25cawzi0	128	27	following	following	JJ
cord-002407-25cawzi0	128	28	year	year	NN
cord-002407-25cawzi0	128	29	[	[	-LRB-
cord-002407-25cawzi0	128	30	86	86	CD
cord-002407-25cawzi0	128	31	]	]	-RRB-
cord-002407-25cawzi0	128	32	.	.	.
cord-002407-25cawzi0	129	1	Seasonal	seasonal	JJ
cord-002407-25cawzi0	129	2	influenza	influenza	NN
cord-002407-25cawzi0	129	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	129	4	must	must	MD
cord-002407-25cawzi0	129	5	protect	protect	VB
cord-002407-25cawzi0	129	6	against	against	IN
cord-002407-25cawzi0	129	7	H1N1	H1N1	NNP
cord-002407-25cawzi0	129	8	,	,	,
cord-002407-25cawzi0	129	9	H3N2	H3N2	NNP
cord-002407-25cawzi0	129	10	and	and	CC
cord-002407-25cawzi0	129	11	B	B	NNP
cord-002407-25cawzi0	129	12	viral	viral	JJ
cord-002407-25cawzi0	129	13	strains	strain	NNS
cord-002407-25cawzi0	129	14	currently	currently	RB
cord-002407-25cawzi0	129	15	circulating	circulate	VBG
cord-002407-25cawzi0	129	16	in	in	IN
cord-002407-25cawzi0	129	17	humans	human	NNS
cord-002407-25cawzi0	129	18	globally	globally	RB
cord-002407-25cawzi0	129	19	[	[	-LRB-
cord-002407-25cawzi0	129	20	34	34	CD
cord-002407-25cawzi0	129	21	,	,	,
cord-002407-25cawzi0	129	22	86	86	CD
cord-002407-25cawzi0	129	23	]	]	-RRB-
cord-002407-25cawzi0	129	24	.	.	.
cord-002407-25cawzi0	130	1	The	the	DT
cord-002407-25cawzi0	130	2	main	main	JJ
cord-002407-25cawzi0	130	3	goals	goal	NNS
cord-002407-25cawzi0	130	4	of	of	IN
cord-002407-25cawzi0	130	5	influenza	influenza	NN
cord-002407-25cawzi0	130	6	vaccines	vaccine	NNS
cord-002407-25cawzi0	130	7	are	be	VBP
cord-002407-25cawzi0	130	8	the	the	DT
cord-002407-25cawzi0	130	9	protection	protection	NN
cord-002407-25cawzi0	130	10	against	against	IN
cord-002407-25cawzi0	130	11	infection	infection	NN
cord-002407-25cawzi0	130	12	and	and	CC
cord-002407-25cawzi0	130	13	disease	disease	NN
cord-002407-25cawzi0	130	14	caused	cause	VBN
cord-002407-25cawzi0	130	15	by	by	IN
cord-002407-25cawzi0	130	16	influenza	influenza	NN
cord-002407-25cawzi0	130	17	infections	infection	NNS
cord-002407-25cawzi0	130	18	and	and	CC
cord-002407-25cawzi0	130	19	to	to	TO
cord-002407-25cawzi0	130	20	restrict	restrict	VB
cord-002407-25cawzi0	130	21	virus	virus	NN
cord-002407-25cawzi0	130	22	transmission	transmission	NN
cord-002407-25cawzi0	130	23	within	within	IN
cord-002407-25cawzi0	130	24	the	the	DT
cord-002407-25cawzi0	130	25	population	population	NN
cord-002407-25cawzi0	130	26	[	[	-LRB-
cord-002407-25cawzi0	130	27	67	67	CD
cord-002407-25cawzi0	130	28	,	,	,
cord-002407-25cawzi0	130	29	94	94	CD
cord-002407-25cawzi0	130	30	]	]	-RRB-
cord-002407-25cawzi0	130	31	.	.	.
cord-002407-25cawzi0	131	1	NAb	nab	JJ
cord-002407-25cawzi0	131	2	responses	response	NNS
cord-002407-25cawzi0	131	3	,	,	,
cord-002407-25cawzi0	131	4	commonly	commonly	RB
cord-002407-25cawzi0	131	5	assessed	assess	VBN
cord-002407-25cawzi0	131	6	by	by	IN
cord-002407-25cawzi0	131	7	measuring	measure	VBG
cord-002407-25cawzi0	131	8	hemagglutination	hemagglutination	NN
cord-002407-25cawzi0	131	9	inhibition	inhibition	NN
cord-002407-25cawzi0	131	10	(	(	-LRB-
cord-002407-25cawzi0	131	11	HAI	HAI	NNP
cord-002407-25cawzi0	131	12	)	)	-RRB-
cord-002407-25cawzi0	131	13	titers	titer	NNS
cord-002407-25cawzi0	131	14	,	,	,
cord-002407-25cawzi0	131	15	are	be	VBP
cord-002407-25cawzi0	131	16	currently	currently	RB
cord-002407-25cawzi0	131	17	used	use	VBN
cord-002407-25cawzi0	131	18	as	as	IN
cord-002407-25cawzi0	131	19	a	a	DT
cord-002407-25cawzi0	131	20	serological	serological	JJ
cord-002407-25cawzi0	131	21	marker	marker	NN
cord-002407-25cawzi0	131	22	of	of	IN
cord-002407-25cawzi0	131	23	the	the	DT
cord-002407-25cawzi0	131	24	efficient	efficient	JJ
cord-002407-25cawzi0	131	25	immunological	immunological	JJ
cord-002407-25cawzi0	131	26	response	response	NN
cord-002407-25cawzi0	131	27	to	to	IN
cord-002407-25cawzi0	131	28	the	the	DT
cord-002407-25cawzi0	131	29	vaccine	vaccine	NN
cord-002407-25cawzi0	131	30	.	.	.
cord-002407-25cawzi0	132	1	The	the	DT
cord-002407-25cawzi0	132	2	effectiveness	effectiveness	NN
cord-002407-25cawzi0	132	3	of	of	IN
cord-002407-25cawzi0	132	4	influenza	influenza	NN
cord-002407-25cawzi0	132	5	vaccines	vaccine	NNS
cord-002407-25cawzi0	132	6	is	be	VBZ
cord-002407-25cawzi0	132	7	variable	variable	JJ
cord-002407-25cawzi0	132	8	and	and	CC
cord-002407-25cawzi0	132	9	usually	usually	RB
cord-002407-25cawzi0	132	10	higher	high	JJR
cord-002407-25cawzi0	132	11	in	in	IN
cord-002407-25cawzi0	132	12	children	child	NNS
cord-002407-25cawzi0	132	13	and	and	CC
cord-002407-25cawzi0	132	14	in	in	IN
cord-002407-25cawzi0	132	15	healthy	healthy	JJ
cord-002407-25cawzi0	132	16	adults	adult	NNS
cord-002407-25cawzi0	132	17	under	under	IN
cord-002407-25cawzi0	132	18	the	the	DT
cord-002407-25cawzi0	132	19	age	age	NN
cord-002407-25cawzi0	132	20	of	of	IN
cord-002407-25cawzi0	132	21	65	65	CD
cord-002407-25cawzi0	132	22	.	.	.
cord-002407-25cawzi0	133	1	In	in	IN
cord-002407-25cawzi0	133	2	individuals	individual	NNS
cord-002407-25cawzi0	133	3	above	above	IN
cord-002407-25cawzi0	133	4	65	65	CD
cord-002407-25cawzi0	133	5	years	year	NNS
cord-002407-25cawzi0	133	6	of	of	IN
cord-002407-25cawzi0	133	7	age	age	NN
cord-002407-25cawzi0	133	8	,	,	,
cord-002407-25cawzi0	133	9	lower	low	JJR
cord-002407-25cawzi0	133	10	effectiveness	effectiveness	NN
cord-002407-25cawzi0	133	11	has	have	VBZ
cord-002407-25cawzi0	133	12	been	be	VBN
cord-002407-25cawzi0	133	13	observed	observe	VBN
cord-002407-25cawzi0	133	14	[	[	-LRB-
cord-002407-25cawzi0	133	15	61	61	CD
cord-002407-25cawzi0	133	16	,	,	,
cord-002407-25cawzi0	133	17	71	71	CD
cord-002407-25cawzi0	133	18	,	,	,
cord-002407-25cawzi0	133	19	95	95	CD
cord-002407-25cawzi0	133	20	]	]	-RRB-
cord-002407-25cawzi0	133	21	.	.	.
cord-002407-25cawzi0	134	1	Recommendations	recommendation	NNS
cord-002407-25cawzi0	134	2	for	for	IN
cord-002407-25cawzi0	134	3	influenza	influenza	NN
cord-002407-25cawzi0	134	4	vaccination	vaccination	NN
cord-002407-25cawzi0	134	5	differ	differ	VBP
cord-002407-25cawzi0	134	6	between	between	IN
cord-002407-25cawzi0	134	7	countries	country	NNS
cord-002407-25cawzi0	134	8	,	,	,
cord-002407-25cawzi0	134	9	but	but	CC
cord-002407-25cawzi0	134	10	since	since	IN
cord-002407-25cawzi0	134	11	influenza	influenza	NN
cord-002407-25cawzi0	134	12	vaccines	vaccine	NNS
cord-002407-25cawzi0	134	13	do	do	VBP
cord-002407-25cawzi0	134	14	not	not	RB
cord-002407-25cawzi0	134	15	induce	induce	VB
cord-002407-25cawzi0	134	16	long	long	RB
cord-002407-25cawzi0	134	17	-	-	HYPH
cord-002407-25cawzi0	134	18	lasting	last	VBG
cord-002407-25cawzi0	134	19	antibody	antibody	NN
cord-002407-25cawzi0	134	20	protection	protection	NN
cord-002407-25cawzi0	134	21	,	,	,
cord-002407-25cawzi0	134	22	annual	annual	JJ
cord-002407-25cawzi0	134	23	influenza	influenza	NN
cord-002407-25cawzi0	134	24	vaccinations	vaccination	NNS
cord-002407-25cawzi0	134	25	are	be	VBP
cord-002407-25cawzi0	134	26	recommended	recommend	VBN
cord-002407-25cawzi0	134	27	.	.	.
cord-002407-25cawzi0	135	1	Nowadays	nowadays	RB
cord-002407-25cawzi0	135	2	,	,	,
cord-002407-25cawzi0	135	3	the	the	DT
cord-002407-25cawzi0	135	4	most	most	RBS
cord-002407-25cawzi0	135	5	used	use	VBN
cord-002407-25cawzi0	135	6	influenza	influenza	NN
cord-002407-25cawzi0	135	7	vaccines	vaccine	NNS
cord-002407-25cawzi0	135	8	can	can	MD
cord-002407-25cawzi0	135	9	be	be	VB
cord-002407-25cawzi0	135	10	divided	divide	VBN
cord-002407-25cawzi0	135	11	into	into	IN
cord-002407-25cawzi0	135	12	IIV	IIV	NNP
cord-002407-25cawzi0	135	13	and	and	CC
cord-002407-25cawzi0	135	14	LAIV	LAIV	NNP
cord-002407-25cawzi0	135	15	[	[	-LRB-
cord-002407-25cawzi0	135	16	65	65	CD
cord-002407-25cawzi0	135	17	,	,	,
cord-002407-25cawzi0	135	18	66	66	CD
cord-002407-25cawzi0	135	19	,	,	,
cord-002407-25cawzi0	135	20	72	72	CD
cord-002407-25cawzi0	135	21	,	,	,
cord-002407-25cawzi0	135	22	73	73	CD
cord-002407-25cawzi0	135	23	,	,	,
cord-002407-25cawzi0	135	24	96	96	CD
cord-002407-25cawzi0	135	25	]	]	-RRB-
cord-002407-25cawzi0	135	26	.	.	.
cord-002407-25cawzi0	136	1	Killed	kill	VBN
cord-002407-25cawzi0	136	2	virus	virus	NN
cord-002407-25cawzi0	136	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	136	4	or	or	CC
cord-002407-25cawzi0	136	5	IIV	IIV	NNP
cord-002407-25cawzi0	136	6	are	be	VBP
cord-002407-25cawzi0	136	7	generally	generally	RB
cord-002407-25cawzi0	136	8	administered	administer	VBN
cord-002407-25cawzi0	136	9	intramuscularly	intramuscularly	RB
cord-002407-25cawzi0	136	10	and	and	CC
cord-002407-25cawzi0	136	11	can	can	MD
cord-002407-25cawzi0	136	12	be	be	VB
cord-002407-25cawzi0	136	13	classified	classify	VBN
cord-002407-25cawzi0	136	14	as	as	IN
cord-002407-25cawzi0	136	15	whole	whole	JJ
cord-002407-25cawzi0	136	16	virus	virus	NN
cord-002407-25cawzi0	136	17	vaccines	vaccine	NNS
cord-002407-25cawzi0	136	18	or	or	CC
cord-002407-25cawzi0	136	19	split	split	VB
cord-002407-25cawzi0	136	20	vaccines	vaccine	NNS
cord-002407-25cawzi0	136	21	[	[	-LRB-
cord-002407-25cawzi0	136	22	66	66	CD
cord-002407-25cawzi0	136	23	,	,	,
cord-002407-25cawzi0	136	24	71	71	CD
cord-002407-25cawzi0	136	25	,	,	,
cord-002407-25cawzi0	136	26	97	97	CD
cord-002407-25cawzi0	136	27	,	,	,
cord-002407-25cawzi0	136	28	98	98	CD
cord-002407-25cawzi0	136	29	]	]	-RRB-
cord-002407-25cawzi0	136	30	.	.	.
cord-002407-25cawzi0	137	1	Whole	whole	JJ
cord-002407-25cawzi0	137	2	virus	virus	NN
cord-002407-25cawzi0	137	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	137	4	were	be	VBD
cord-002407-25cawzi0	137	5	the	the	DT
cord-002407-25cawzi0	137	6	first	first	JJ
cord-002407-25cawzi0	137	7	to	to	TO
cord-002407-25cawzi0	137	8	be	be	VB
cord-002407-25cawzi0	137	9	developed	develop	VBN
cord-002407-25cawzi0	137	10	.	.	.
cord-002407-25cawzi0	138	1	The	the	DT
cord-002407-25cawzi0	138	2	influenza	influenza	NN
cord-002407-25cawzi0	138	3	virus	virus	NN
cord-002407-25cawzi0	138	4	is	be	VBZ
cord-002407-25cawzi0	138	5	grown	grow	VBN
cord-002407-25cawzi0	138	6	in	in	IN
cord-002407-25cawzi0	138	7	embryonated	embryonate	VBN
cord-002407-25cawzi0	138	8	chicken	chicken	NN
cord-002407-25cawzi0	138	9	eggs	egg	NNS
cord-002407-25cawzi0	138	10	,	,	,
cord-002407-25cawzi0	138	11	subsequently	subsequently	RB
cord-002407-25cawzi0	138	12	purified	purify	VBN
cord-002407-25cawzi0	138	13	,	,	,
cord-002407-25cawzi0	138	14	concentrated	concentrated	JJ
cord-002407-25cawzi0	138	15	and	and	CC
cord-002407-25cawzi0	138	16	chemically	chemically	RB
cord-002407-25cawzi0	138	17	inactivated	inactivate	VBN
cord-002407-25cawzi0	138	18	with	with	IN
cord-002407-25cawzi0	138	19	formaldehyde	formaldehyde	NN
cord-002407-25cawzi0	138	20	[	[	-LRB-
cord-002407-25cawzi0	138	21	98	98	CD
cord-002407-25cawzi0	138	22	]	]	-RRB-
cord-002407-25cawzi0	139	1	(	(	-LRB-
cord-002407-25cawzi0	139	2	Figure	figure	NN
cord-002407-25cawzi0	139	3	2	2	CD
cord-002407-25cawzi0	139	4	)	)	-RRB-
cord-002407-25cawzi0	139	5	.	.	.
cord-002407-25cawzi0	140	1	Whole	whole	JJ
cord-002407-25cawzi0	140	2	virus	virus	NN
cord-002407-25cawzi0	140	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	140	4	are	be	VBP
cord-002407-25cawzi0	140	5	safe	safe	JJ
cord-002407-25cawzi0	140	6	and	and	CC
cord-002407-25cawzi0	140	7	well	well	RB
cord-002407-25cawzi0	140	8	tolerated	tolerate	VBN
cord-002407-25cawzi0	140	9	,	,	,
cord-002407-25cawzi0	140	10	with	with	IN
cord-002407-25cawzi0	140	11	an	an	DT
cord-002407-25cawzi0	140	12	efficacy	efficacy	NN
cord-002407-25cawzi0	140	13	of	of	IN
cord-002407-25cawzi0	140	14	60%-90	60%-90	CD
cord-002407-25cawzi0	140	15	%	%	NN
cord-002407-25cawzi0	140	16	in	in	IN
cord-002407-25cawzi0	140	17	children	child	NNS
cord-002407-25cawzi0	140	18	and	and	CC
cord-002407-25cawzi0	140	19	adults	adult	NNS
cord-002407-25cawzi0	140	20	.	.	.
cord-002407-25cawzi0	141	1	On	on	IN
cord-002407-25cawzi0	141	2	the	the	DT
cord-002407-25cawzi0	141	3	other	other	JJ
cord-002407-25cawzi0	141	4	hand	hand	NN
cord-002407-25cawzi0	141	5	,	,	,
cord-002407-25cawzi0	141	6	the	the	DT
cord-002407-25cawzi0	141	7	split	split	NN
cord-002407-25cawzi0	141	8	-	-	HYPH
cord-002407-25cawzi0	141	9	virus	virus	NN
cord-002407-25cawzi0	141	10	vaccine	vaccine	NN
cord-002407-25cawzi0	141	11	exposes	expose	VBZ
cord-002407-25cawzi0	141	12	all	all	DT
cord-002407-25cawzi0	141	13	viral	viral	JJ
cord-002407-25cawzi0	141	14	proteins	protein	NNS
cord-002407-25cawzi0	141	15	and	and	CC
cord-002407-25cawzi0	141	16	subviral	subviral	JJ
cord-002407-25cawzi0	141	17	elements	element	NNS
cord-002407-25cawzi0	141	18	upon	upon	IN
cord-002407-25cawzi0	141	19	dissociation	dissociation	NN
cord-002407-25cawzi0	141	20	of	of	IN
cord-002407-25cawzi0	141	21	the	the	DT
cord-002407-25cawzi0	141	22	virions	virion	NNS
cord-002407-25cawzi0	141	23	by	by	IN
cord-002407-25cawzi0	141	24	a	a	DT
cord-002407-25cawzi0	141	25	nonionic	nonionic	JJ
cord-002407-25cawzi0	141	26	detergent	detergent	NN
cord-002407-25cawzi0	141	27	treatment	treatment	NN
cord-002407-25cawzi0	141	28	step	step	NN
cord-002407-25cawzi0	141	29	[	[	-LRB-
cord-002407-25cawzi0	141	30	97	97	CD
cord-002407-25cawzi0	141	31	,	,	,
cord-002407-25cawzi0	141	32	99	99	CD
cord-002407-25cawzi0	141	33	]	]	-RRB-
cord-002407-25cawzi0	141	34	.	.	.
cord-002407-25cawzi0	142	1	Most	Most	JJS
cord-002407-25cawzi0	142	2	influenza	influenza	NN
cord-002407-25cawzi0	142	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	142	4	in	in	IN
cord-002407-25cawzi0	142	5	the	the	DT
cord-002407-25cawzi0	142	6	U.S.	U.S.	NNP
cord-002407-25cawzi0	142	7	and	and	CC
cord-002407-25cawzi0	142	8	Europe	Europe	NNP
cord-002407-25cawzi0	142	9	are	be	VBP
cord-002407-25cawzi0	142	10	egg	egg	NN
cord-002407-25cawzi0	142	11	-	-	HYPH
cord-002407-25cawzi0	142	12	produced	produce	VBN
cord-002407-25cawzi0	142	13	,	,	,
cord-002407-25cawzi0	142	14	formaldehyde	formaldehyde	NN
cord-002407-25cawzi0	142	15	-	-	HYPH
cord-002407-25cawzi0	142	16	inactivated	inactivate	VBN
cord-002407-25cawzi0	142	17	,	,	,
cord-002407-25cawzi0	142	18	then	then	RB
cord-002407-25cawzi0	142	19	chemically	chemically	RB
cord-002407-25cawzi0	142	20	disrupted	disrupt	VBN
cord-002407-25cawzi0	142	21	with	with	IN
cord-002407-25cawzi0	142	22	nonionic	nonionic	JJ
cord-002407-25cawzi0	142	23	detergents	detergent	NNS
cord-002407-25cawzi0	142	24	after	after	IN
cord-002407-25cawzi0	142	25	purification	purification	NN
cord-002407-25cawzi0	142	26	.	.	.
cord-002407-25cawzi0	143	1	Unlike	unlike	IN
cord-002407-25cawzi0	143	2	virus	virus	NN
cord-002407-25cawzi0	143	3	-	-	HYPH
cord-002407-25cawzi0	143	4	based	base	VBN
cord-002407-25cawzi0	143	5	vaccines	vaccine	NNS
cord-002407-25cawzi0	143	6	,	,	,
cord-002407-25cawzi0	143	7	subunit	subunit	NN
cord-002407-25cawzi0	143	8	influenza	influenza	NN
cord-002407-25cawzi0	143	9	vaccines	vaccine	NNS
cord-002407-25cawzi0	143	10	consist	consist	VBP
cord-002407-25cawzi0	143	11	of	of	IN
cord-002407-25cawzi0	143	12	purified	purify	VBN
cord-002407-25cawzi0	143	13	viral	viral	JJ
cord-002407-25cawzi0	143	14	HA	HA	NNP
cord-002407-25cawzi0	143	15	or	or	CC
cord-002407-25cawzi0	143	16	HA	HA	NNP
cord-002407-25cawzi0	143	17	/	/	SYM
cord-002407-25cawzi0	143	18	NA	NA	NNP
cord-002407-25cawzi0	143	19	proteins	protein	NNS
cord-002407-25cawzi0	143	20	without	without	IN
cord-002407-25cawzi0	143	21	the	the	DT
cord-002407-25cawzi0	143	22	other	other	JJ
cord-002407-25cawzi0	143	23	viral	viral	JJ
cord-002407-25cawzi0	143	24	components	component	NNS
cord-002407-25cawzi0	143	25	[	[	-LRB-
cord-002407-25cawzi0	143	26	68	68	CD
cord-002407-25cawzi0	143	27	]	]	-RRB-
cord-002407-25cawzi0	143	28	.	.	.
cord-002407-25cawzi0	144	1	These	these	DT
cord-002407-25cawzi0	144	2	subunit	subunit	NN
cord-002407-25cawzi0	144	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	144	4	can	can	MD
cord-002407-25cawzi0	144	5	be	be	VB
cord-002407-25cawzi0	144	6	produced	produce	VBN
cord-002407-25cawzi0	144	7	in	in	IN
cord-002407-25cawzi0	144	8	eggs	egg	NNS
cord-002407-25cawzi0	144	9	if	if	IN
cord-002407-25cawzi0	144	10	the	the	DT
cord-002407-25cawzi0	144	11	viral	viral	JJ
cord-002407-25cawzi0	144	12	proteins	protein	NNS
cord-002407-25cawzi0	144	13	are	be	VBP
cord-002407-25cawzi0	144	14	prepared	prepare	VBN
cord-002407-25cawzi0	144	15	from	from	IN
cord-002407-25cawzi0	144	16	viruses	virus	NNS
cord-002407-25cawzi0	144	17	where	where	WRB
cord-002407-25cawzi0	144	18	HA	HA	NNP
cord-002407-25cawzi0	144	19	/	/	SYM
cord-002407-25cawzi0	144	20	NA	NA	NNP
cord-002407-25cawzi0	144	21	have	have	VBP
cord-002407-25cawzi0	144	22	been	be	VBN
cord-002407-25cawzi0	144	23	purified	purify	VBN
cord-002407-25cawzi0	144	24	by	by	IN
cord-002407-25cawzi0	144	25	removal	removal	NN
cord-002407-25cawzi0	144	26	of	of	IN
cord-002407-25cawzi0	144	27	other	other	JJ
cord-002407-25cawzi0	144	28	viral	viral	JJ
cord-002407-25cawzi0	144	29	component	component	NN
cord-002407-25cawzi0	144	30	.	.	.
cord-002407-25cawzi0	145	1	In	in	IN
cord-002407-25cawzi0	145	2	addition	addition	NN
cord-002407-25cawzi0	145	3	,	,	,
cord-002407-25cawzi0	145	4	the	the	DT
cord-002407-25cawzi0	145	5	subunit	subunit	NN
cord-002407-25cawzi0	145	6	vaccines	vaccine	NNS
cord-002407-25cawzi0	145	7	can	can	MD
cord-002407-25cawzi0	145	8	be	be	VB
cord-002407-25cawzi0	145	9	generated	generate	VBN
cord-002407-25cawzi0	145	10	using	use	VBG
cord-002407-25cawzi0	145	11	novel	novel	NN
cord-002407-25cawzi0	145	12	manufacturing	manufacturing	NN
cord-002407-25cawzi0	145	13	technologies	technology	NNS
cord-002407-25cawzi0	145	14	[	[	-LRB-
cord-002407-25cawzi0	145	15	98	98	CD
cord-002407-25cawzi0	145	16	,	,	,
cord-002407-25cawzi0	145	17	100	100	CD
cord-002407-25cawzi0	145	18	]	]	-RRB-
cord-002407-25cawzi0	145	19	,	,	,
cord-002407-25cawzi0	145	20	which	which	WDT
cord-002407-25cawzi0	145	21	allows	allow	VBZ
cord-002407-25cawzi0	145	22	for	for	IN
cord-002407-25cawzi0	145	23	the	the	DT
cord-002407-25cawzi0	145	24	production	production	NN
cord-002407-25cawzi0	145	25	of	of	IN
cord-002407-25cawzi0	145	26	large	large	JJ
cord-002407-25cawzi0	145	27	quantities	quantity	NNS
cord-002407-25cawzi0	145	28	of	of	IN
cord-002407-25cawzi0	145	29	the	the	DT
cord-002407-25cawzi0	145	30	viral	viral	JJ
cord-002407-25cawzi0	145	31	HA	HA	NNP
cord-002407-25cawzi0	145	32	using	use	VBG
cord-002407-25cawzi0	145	33	baculovirus	baculovirus	NNP
cord-002407-25cawzi0	145	34	expression	expression	NN
cord-002407-25cawzi0	145	35	systems	system	NNS
cord-002407-25cawzi0	145	36	and	and	CC
cord-002407-25cawzi0	145	37	recombinant	recombinant	JJ
cord-002407-25cawzi0	145	38	DNA	dna	NN
cord-002407-25cawzi0	145	39	technologies	technology	NNS
cord-002407-25cawzi0	145	40	[	[	-LRB-
cord-002407-25cawzi0	145	41	100	100	CD
cord-002407-25cawzi0	145	42	]	]	-RRB-
cord-002407-25cawzi0	145	43	.	.	.
cord-002407-25cawzi0	146	1	The	the	DT
cord-002407-25cawzi0	146	2	IAV	IAV	NNP
cord-002407-25cawzi0	146	3	strains	strain	NNS
cord-002407-25cawzi0	146	4	that	that	WDT
cord-002407-25cawzi0	146	5	are	be	VBP
cord-002407-25cawzi0	146	6	used	use	VBN
cord-002407-25cawzi0	146	7	in	in	IN
cord-002407-25cawzi0	146	8	vaccine	vaccine	NN
cord-002407-25cawzi0	146	9	manufacture	manufacture	NN
cord-002407-25cawzi0	146	10	are	be	VBP
cord-002407-25cawzi0	146	11	high	high	JJ
cord-002407-25cawzi0	146	12	-	-	HYPH
cord-002407-25cawzi0	146	13	growth	growth	NN
cord-002407-25cawzi0	146	14	6	6	CD
cord-002407-25cawzi0	146	15	+	+	SYM
cord-002407-25cawzi0	146	16	2	2	CD
cord-002407-25cawzi0	146	17	reassortants	reassortant	NNS
cord-002407-25cawzi0	146	18	containing	contain	VBG
cord-002407-25cawzi0	146	19	the	the	DT
cord-002407-25cawzi0	146	20	HA	HA	NNP
cord-002407-25cawzi0	146	21	and	and	CC
cord-002407-25cawzi0	146	22	NA	NA	NNP
cord-002407-25cawzi0	146	23	gene	gene	NN
cord-002407-25cawzi0	146	24	segments	segment	NNS
cord-002407-25cawzi0	146	25	from	from	IN
cord-002407-25cawzi0	146	26	the	the	DT
cord-002407-25cawzi0	146	27	target	target	NN
cord-002407-25cawzi0	146	28	strains	strain	NNS
cord-002407-25cawzi0	146	29	in	in	IN
cord-002407-25cawzi0	146	30	the	the	DT
cord-002407-25cawzi0	146	31	backbone	backbone	NN
cord-002407-25cawzi0	146	32	of	of	IN
cord-002407-25cawzi0	146	33	influenza	influenza	NN
cord-002407-25cawzi0	146	34	A	A	NNP
cord-002407-25cawzi0	146	35	/	/	SYM
cord-002407-25cawzi0	146	36	Puerto	Puerto	NNP
cord-002407-25cawzi0	146	37	Rico/8/1934	Rico/8/1934	NNP
cord-002407-25cawzi0	146	38	H1N1	H1N1	NNP
cord-002407-25cawzi0	146	39	(	(	-LRB-
cord-002407-25cawzi0	146	40	PR8	PR8	NNP
cord-002407-25cawzi0	146	41	)	)	-RRB-
cord-002407-25cawzi0	146	42	or	or	CC
cord-002407-25cawzi0	146	43	other	other	JJ
cord-002407-25cawzi0	146	44	high	high	JJ
cord-002407-25cawzi0	146	45	growth	growth	NN
cord-002407-25cawzi0	146	46	virus	virus	NN
cord-002407-25cawzi0	146	47	.	.	.
cord-002407-25cawzi0	147	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	147	2	PR8	PR8	NNP
cord-002407-25cawzi0	147	3	replicates	replicate	VBZ
cord-002407-25cawzi0	147	4	at	at	IN
cord-002407-25cawzi0	147	5	high	high	JJ
cord-002407-25cawzi0	147	6	titers	titer	NNS
cord-002407-25cawzi0	147	7	in	in	IN
cord-002407-25cawzi0	147	8	eggs	egg	NNS
cord-002407-25cawzi0	147	9	and	and	CC
cord-002407-25cawzi0	147	10	cells	cell	NNS
cord-002407-25cawzi0	147	11	and	and	CC
cord-002407-25cawzi0	147	12	also	also	RB
cord-002407-25cawzi0	147	13	has	have	VBZ
cord-002407-25cawzi0	147	14	a	a	DT
cord-002407-25cawzi0	147	15	favorable	favorable	JJ
cord-002407-25cawzi0	147	16	safety	safety	NN
cord-002407-25cawzi0	147	17	profile	profile	NN
cord-002407-25cawzi0	147	18	in	in	IN
cord-002407-25cawzi0	147	19	humans	human	NNS
cord-002407-25cawzi0	147	20	[	[	-LRB-
cord-002407-25cawzi0	147	21	98	98	CD
cord-002407-25cawzi0	147	22	,	,	,
cord-002407-25cawzi0	147	23	101	101	CD
cord-002407-25cawzi0	147	24	]	]	-RRB-
cord-002407-25cawzi0	148	1	(	(	-LRB-
cord-002407-25cawzi0	148	2	Figure	figure	NN
cord-002407-25cawzi0	148	3	2A	2a	CD
cord-002407-25cawzi0	148	4	)	)	-RRB-
cord-002407-25cawzi0	148	5	.	.	.
cord-002407-25cawzi0	149	1	To	to	TO
cord-002407-25cawzi0	149	2	generate	generate	VB
cord-002407-25cawzi0	149	3	the	the	DT
cord-002407-25cawzi0	149	4	reassortant	reassortant	JJ
cord-002407-25cawzi0	149	5	viruses	virus	NNS
cord-002407-25cawzi0	149	6	,	,	,
cord-002407-25cawzi0	149	7	eggs	egg	NNS
cord-002407-25cawzi0	149	8	are	be	VBP
cord-002407-25cawzi0	149	9	co	co	JJ
cord-002407-25cawzi0	149	10	-	-	JJ
cord-002407-25cawzi0	149	11	infected	infected	JJ
cord-002407-25cawzi0	150	1	with	with	IN
cord-002407-25cawzi0	150	2	PR8	PR8	NNP
cord-002407-25cawzi0	150	3	and	and	CC
cord-002407-25cawzi0	150	4	seasonal	seasonal	JJ
cord-002407-25cawzi0	150	5	strains	strain	NNS
cord-002407-25cawzi0	150	6	(	(	-LRB-
cord-002407-25cawzi0	150	7	Figure	figure	NN
cord-002407-25cawzi0	150	8	2A	2a	CD
cord-002407-25cawzi0	150	9	)	)	-RRB-
cord-002407-25cawzi0	150	10	.	.	.
cord-002407-25cawzi0	151	1	Selection	selection	NN
cord-002407-25cawzi0	151	2	of	of	IN
cord-002407-25cawzi0	151	3	appropriated	appropriate	VBN
cord-002407-25cawzi0	151	4	seed	seed	NN
cord-002407-25cawzi0	151	5	vaccine	vaccine	NN
cord-002407-25cawzi0	151	6	viruses	virus	NNS
cord-002407-25cawzi0	151	7	is	be	VBZ
cord-002407-25cawzi0	151	8	made	make	VBN
cord-002407-25cawzi0	151	9	by	by	IN
cord-002407-25cawzi0	151	10	amplification	amplification	NN
cord-002407-25cawzi0	151	11	in	in	IN
cord-002407-25cawzi0	151	12	the	the	DT
cord-002407-25cawzi0	151	13	presence	presence	NN
cord-002407-25cawzi0	151	14	of	of	IN
cord-002407-25cawzi0	151	15	PR8	PR8	NNP
cord-002407-25cawzi0	151	16	HA	HA	NNP
cord-002407-25cawzi0	151	17	and	and	CC
cord-002407-25cawzi0	151	18	NA	NA	NNP
cord-002407-25cawzi0	151	19	NAbs	NAbs	NNP
cord-002407-25cawzi0	151	20	[	[	-LRB-
cord-002407-25cawzi0	151	21	98	98	CD
cord-002407-25cawzi0	151	22	]	]	-RRB-
cord-002407-25cawzi0	152	1	(	(	-LRB-
cord-002407-25cawzi0	152	2	Figure	figure	NN
cord-002407-25cawzi0	152	3	2A	2a	CD
cord-002407-25cawzi0	152	4	)	)	-RRB-
cord-002407-25cawzi0	152	5	.	.	.
cord-002407-25cawzi0	153	1	Then	then	RB
cord-002407-25cawzi0	153	2	,	,	,
cord-002407-25cawzi0	153	3	selected	select	VBN
cord-002407-25cawzi0	153	4	viruses	virus	NNS
cord-002407-25cawzi0	153	5	are	be	VBP
cord-002407-25cawzi0	153	6	cloned	clone	VBN
cord-002407-25cawzi0	153	7	and	and	CC
cord-002407-25cawzi0	153	8	sequenced	sequence	VBN
cord-002407-25cawzi0	153	9	for	for	IN
cord-002407-25cawzi0	153	10	confirmation	confirmation	NN
cord-002407-25cawzi0	153	11	.	.	.
cord-002407-25cawzi0	154	1	The	the	DT
cord-002407-25cawzi0	154	2	IBV	IBV	NNP
cord-002407-25cawzi0	154	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	154	4	are	be	VBP
cord-002407-25cawzi0	154	5	typically	typically	RB
cord-002407-25cawzi0	154	6	wild	wild	JJ
cord-002407-25cawzi0	154	7	-	-	HYPH
cord-002407-25cawzi0	154	8	type	type	NN
cord-002407-25cawzi0	154	9	(	(	-LRB-
cord-002407-25cawzi0	154	10	WT	WT	NNP
cord-002407-25cawzi0	154	11	)	)	-RRB-
cord-002407-25cawzi0	154	12	viruses	virus	NNS
cord-002407-25cawzi0	154	13	.	.	.
cord-002407-25cawzi0	155	1	However	however	RB
cord-002407-25cawzi0	155	2	,	,	,
cord-002407-25cawzi0	155	3	IBV	IBV	NNP
cord-002407-25cawzi0	155	4	reassortants	reassortant	NNS
cord-002407-25cawzi0	155	5	are	be	VBP
cord-002407-25cawzi0	155	6	used	use	VBN
cord-002407-25cawzi0	155	7	if	if	IN
cord-002407-25cawzi0	155	8	WT	WT	NNP
cord-002407-25cawzi0	155	9	IBV	IBV	NNP
cord-002407-25cawzi0	155	10	growth	growth	NN
cord-002407-25cawzi0	155	11	properties	property	NNS
cord-002407-25cawzi0	155	12	are	be	VBP
cord-002407-25cawzi0	155	13	not	not	RB
cord-002407-25cawzi0	155	14	optimal	optimal	JJ
cord-002407-25cawzi0	155	15	for	for	IN
cord-002407-25cawzi0	155	16	efficient	efficient	JJ
cord-002407-25cawzi0	155	17	growth	growth	NN
cord-002407-25cawzi0	155	18	and	and	CC
cord-002407-25cawzi0	155	19	vaccine	vaccine	NN
cord-002407-25cawzi0	155	20	production	production	NN
cord-002407-25cawzi0	155	21	[	[	-LRB-
cord-002407-25cawzi0	155	22	98	98	CD
cord-002407-25cawzi0	155	23	]	]	-RRB-
cord-002407-25cawzi0	155	24	.	.	.
cord-002407-25cawzi0	156	1	The	the	DT
cord-002407-25cawzi0	156	2	remaining	remain	VBG
cord-002407-25cawzi0	156	3	class	class	NN
cord-002407-25cawzi0	156	4	of	of	IN
cord-002407-25cawzi0	156	5	vaccines	vaccine	NNS
cord-002407-25cawzi0	156	6	consists	consist	VBZ
cord-002407-25cawzi0	156	7	of	of	IN
cord-002407-25cawzi0	156	8	live	live	RB
cord-002407-25cawzi0	156	9	-	-	HYPH
cord-002407-25cawzi0	156	10	attenuated	attenuate	VBN
cord-002407-25cawzi0	156	11	influenza	influenza	NN
cord-002407-25cawzi0	156	12	viruses	virus	NNS
cord-002407-25cawzi0	156	13	.	.	.
cord-002407-25cawzi0	157	1	Attenuated	attenuated	JJ
cord-002407-25cawzi0	157	2	human	human	JJ
cord-002407-25cawzi0	157	3	LAIVs	laiv	NNS
cord-002407-25cawzi0	157	4	were	be	VBD
cord-002407-25cawzi0	157	5	developed	develop	VBN
cord-002407-25cawzi0	157	6	in	in	IN
cord-002407-25cawzi0	157	7	the	the	DT
cord-002407-25cawzi0	157	8	1960s	1960	NNS
cord-002407-25cawzi0	157	9	by	by	IN
cord-002407-25cawzi0	157	10	serial	serial	JJ
cord-002407-25cawzi0	157	11	passage	passage	NN
cord-002407-25cawzi0	157	12	of	of	IN
cord-002407-25cawzi0	157	13	the	the	DT
cord-002407-25cawzi0	157	14	virus	virus	NN
cord-002407-25cawzi0	157	15	in	in	IN
cord-002407-25cawzi0	157	16	eggs	egg	NNS
cord-002407-25cawzi0	157	17	using	use	VBG
cord-002407-25cawzi0	157	18	suboptimal	suboptimal	JJ
cord-002407-25cawzi0	157	19	conditions	condition	NNS
cord-002407-25cawzi0	157	20	of	of	IN
cord-002407-25cawzi0	157	21	temperature	temperature	NN
cord-002407-25cawzi0	157	22	.	.	.
cord-002407-25cawzi0	158	1	The	the	DT
cord-002407-25cawzi0	158	2	resulting	result	VBG
cord-002407-25cawzi0	158	3	attenuated	attenuated	JJ
cord-002407-25cawzi0	158	4	viruses	virus	NNS
cord-002407-25cawzi0	158	5	displayed	display	VBD
cord-002407-25cawzi0	158	6	a	a	DT
cord-002407-25cawzi0	158	7	temperature	temperature	NN
cord-002407-25cawzi0	158	8	-	-	HYPH
cord-002407-25cawzi0	158	9	sensitive	sensitive	JJ
cord-002407-25cawzi0	158	10	(	(	-LRB-
cord-002407-25cawzi0	158	11	ts	ts	JJ
cord-002407-25cawzi0	158	12	)	)	-RRB-
cord-002407-25cawzi0	158	13	cold	cold	RB
cord-002407-25cawzi0	158	14	-	-	HYPH
cord-002407-25cawzi0	158	15	adapted	adapt	VBN
cord-002407-25cawzi0	158	16	(	(	-LRB-
cord-002407-25cawzi0	158	17	ca	ca	NNP
cord-002407-25cawzi0	158	18	)	)	-RRB-
cord-002407-25cawzi0	158	19	attenuated	attenuate	VBN
cord-002407-25cawzi0	158	20	(	(	-LRB-
cord-002407-25cawzi0	158	21	att	att	NNP
cord-002407-25cawzi0	158	22	)	)	-RRB-
cord-002407-25cawzi0	158	23	phenotype	phenotype	NN
cord-002407-25cawzi0	158	24	that	that	WDT
cord-002407-25cawzi0	158	25	grew	grow	VBD
cord-002407-25cawzi0	158	26	at	at	IN
cord-002407-25cawzi0	158	27	25	25	CD
cord-002407-25cawzi0	158	28	•	•	NNS
cord-002407-25cawzi0	158	29	C	C	NNP
cord-002407-25cawzi0	158	30	,	,	,
cord-002407-25cawzi0	158	31	but	but	CC
cord-002407-25cawzi0	158	32	not	not	RB
cord-002407-25cawzi0	158	33	at	at	IN
cord-002407-25cawzi0	158	34	temperatures	temperature	NNS
cord-002407-25cawzi0	158	35	found	find	VBN
cord-002407-25cawzi0	158	36	in	in	IN
cord-002407-25cawzi0	158	37	the	the	DT
cord-002407-25cawzi0	158	38	lower	low	JJR
cord-002407-25cawzi0	158	39	respiratory	respiratory	JJ
cord-002407-25cawzi0	158	40	tract	tract	NN
cord-002407-25cawzi0	158	41	(	(	-LRB-
cord-002407-25cawzi0	158	42	>	>	NFP
cord-002407-25cawzi0	158	43	35	35	CD
cord-002407-25cawzi0	158	44	•	•	NN
cord-002407-25cawzi0	158	45	C	c	NN
cord-002407-25cawzi0	158	46	)	)	-RRB-
cord-002407-25cawzi0	158	47	[	[	-LRB-
cord-002407-25cawzi0	158	48	102	102	CD
cord-002407-25cawzi0	158	49	]	]	-RRB-
cord-002407-25cawzi0	158	50	[	[	-LRB-
cord-002407-25cawzi0	158	51	103	103	CD
cord-002407-25cawzi0	158	52	]	]	-RRB-
cord-002407-25cawzi0	158	53	[	[	-LRB-
cord-002407-25cawzi0	158	54	104	104	CD
cord-002407-25cawzi0	158	55	]	]	-RRB-
cord-002407-25cawzi0	158	56	[	[	-LRB-
cord-002407-25cawzi0	158	57	105	105	CD
cord-002407-25cawzi0	158	58	]	]	-RRB-
cord-002407-25cawzi0	158	59	.	.	.
cord-002407-25cawzi0	159	1	Because	because	IN
cord-002407-25cawzi0	159	2	this	this	DT
cord-002407-25cawzi0	159	3	ts	ts	NN
cord-002407-25cawzi0	159	4	,	,	,
cord-002407-25cawzi0	159	5	ca	ca	NNP
cord-002407-25cawzi0	159	6	,	,	,
cord-002407-25cawzi0	159	7	att	att	NNP
cord-002407-25cawzi0	159	8	phenotype	phenotype	NN
cord-002407-25cawzi0	159	9	restricts	restrict	VBZ
cord-002407-25cawzi0	159	10	virus	virus	NN
cord-002407-25cawzi0	159	11	replication	replication	NN
cord-002407-25cawzi0	159	12	to	to	IN
cord-002407-25cawzi0	159	13	the	the	DT
cord-002407-25cawzi0	159	14	upper	upper	JJ
cord-002407-25cawzi0	159	15	respiratory	respiratory	JJ
cord-002407-25cawzi0	159	16	track	track	NN
cord-002407-25cawzi0	159	17	,	,	,
cord-002407-25cawzi0	159	18	these	these	DT
cord-002407-25cawzi0	159	19	viruses	virus	NNS
cord-002407-25cawzi0	159	20	could	could	MD
cord-002407-25cawzi0	159	21	induce	induce	VB
cord-002407-25cawzi0	159	22	local	local	JJ
cord-002407-25cawzi0	159	23	protective	protective	JJ
cord-002407-25cawzi0	159	24	immunological	immunological	JJ
cord-002407-25cawzi0	159	25	responses	response	NNS
cord-002407-25cawzi0	159	26	[	[	-LRB-
cord-002407-25cawzi0	159	27	65	65	CD
cord-002407-25cawzi0	159	28	,	,	,
cord-002407-25cawzi0	159	29	95	95	CD
cord-002407-25cawzi0	159	30	,	,	,
cord-002407-25cawzi0	159	31	96	96	CD
cord-002407-25cawzi0	159	32	,	,	,
cord-002407-25cawzi0	159	33	98	98	CD
cord-002407-25cawzi0	159	34	]	]	-RRB-
cord-002407-25cawzi0	159	35	.	.	.
cord-002407-25cawzi0	160	1	LAIV	LAIV	NNP
cord-002407-25cawzi0	160	2	have	have	VBP
cord-002407-25cawzi0	160	3	been	be	VBN
cord-002407-25cawzi0	160	4	available	available	JJ
cord-002407-25cawzi0	160	5	in	in	IN
cord-002407-25cawzi0	160	6	the	the	DT
cord-002407-25cawzi0	160	7	U.S.	U.S.	NNP
cord-002407-25cawzi0	160	8	since	since	IN
cord-002407-25cawzi0	160	9	2003	2003	CD
cord-002407-25cawzi0	160	10	and	and	CC
cord-002407-25cawzi0	160	11	are	be	VBP
cord-002407-25cawzi0	160	12	administrated	administrate	VBN
cord-002407-25cawzi0	160	13	intranasally	intranasally	RB
cord-002407-25cawzi0	160	14	.	.	.
cord-002407-25cawzi0	161	1	The	the	DT
cord-002407-25cawzi0	161	2	advantages	advantage	NNS
cord-002407-25cawzi0	161	3	of	of	IN
cord-002407-25cawzi0	161	4	a	a	DT
cord-002407-25cawzi0	161	5	live	live	JJ
cord-002407-25cawzi0	161	6	virus	virus	NN
cord-002407-25cawzi0	161	7	vaccine	vaccine	NN
cord-002407-25cawzi0	161	8	,	,	,
cord-002407-25cawzi0	161	9	as	as	IN
cord-002407-25cawzi0	161	10	compared	compare	VBN
cord-002407-25cawzi0	161	11	to	to	IN
cord-002407-25cawzi0	161	12	the	the	DT
cord-002407-25cawzi0	161	13	inactivated	inactivate	VBN
cord-002407-25cawzi0	161	14	virus	virus	NN
cord-002407-25cawzi0	161	15	vaccine	vaccine	NN
cord-002407-25cawzi0	161	16	,	,	,
cord-002407-25cawzi0	161	17	is	be	VBZ
cord-002407-25cawzi0	161	18	that	that	IN
cord-002407-25cawzi0	161	19	it	-PRON-	PRP
cord-002407-25cawzi0	161	20	is	be	VBZ
cord-002407-25cawzi0	161	21	applied	apply	VBN
cord-002407-25cawzi0	161	22	to	to	IN
cord-002407-25cawzi0	161	23	the	the	DT
cord-002407-25cawzi0	161	24	nasal	nasal	NN
cord-002407-25cawzi0	161	25	mucosa	mucosa	NN
cord-002407-25cawzi0	161	26	where	where	WRB
cord-002407-25cawzi0	161	27	the	the	DT
cord-002407-25cawzi0	161	28	vaccine	vaccine	NN
cord-002407-25cawzi0	161	29	can	can	MD
cord-002407-25cawzi0	161	30	induce	induce	VB
cord-002407-25cawzi0	161	31	local	local	JJ
cord-002407-25cawzi0	161	32	immunity	immunity	NN
cord-002407-25cawzi0	161	33	(	(	-LRB-
cord-002407-25cawzi0	161	34	including	include	VBG
cord-002407-25cawzi0	161	35	NAbs	NAbs	NNP
cord-002407-25cawzi0	161	36	)	)	-RRB-
cord-002407-25cawzi0	161	37	,	,	,
cord-002407-25cawzi0	161	38	generate	generate	VBP
cord-002407-25cawzi0	161	39	a	a	DT
cord-002407-25cawzi0	161	40	cellmediated	cellmediate	VBN
cord-002407-25cawzi0	161	41	immune	immune	JJ
cord-002407-25cawzi0	161	42	response	response	NN
cord-002407-25cawzi0	161	43	and	and	CC
cord-002407-25cawzi0	161	44	provide	provide	VB
cord-002407-25cawzi0	161	45	a	a	DT
cord-002407-25cawzi0	161	46	cross	cross	JJ
cord-002407-25cawzi0	161	47	-	-	JJ
cord-002407-25cawzi0	161	48	reactive	reactive	JJ
cord-002407-25cawzi0	161	49	and	and	CC
cord-002407-25cawzi0	161	50	longer	long	RBR
cord-002407-25cawzi0	161	51	lasting	last	VBG
cord-002407-25cawzi0	161	52	immune	immune	JJ
cord-002407-25cawzi0	161	53	response	response	NN
cord-002407-25cawzi0	161	54	[	[	-LRB-
cord-002407-25cawzi0	161	55	106	106	CD
cord-002407-25cawzi0	161	56	]	]	-RRB-
cord-002407-25cawzi0	161	57	.	.	.
cord-002407-25cawzi0	162	1	LAIV	LAIV	NNP
cord-002407-25cawzi0	162	2	have	have	VBP
cord-002407-25cawzi0	162	3	been	be	VBN
cord-002407-25cawzi0	162	4	available	available	JJ
cord-002407-25cawzi0	162	5	in	in	IN
cord-002407-25cawzi0	162	6	the	the	DT
cord-002407-25cawzi0	162	7	U.S.	U.S.	NNP
cord-002407-25cawzi0	162	8	since	since	IN
cord-002407-25cawzi0	162	9	2003	2003	CD
cord-002407-25cawzi0	162	10	and	and	CC
cord-002407-25cawzi0	162	11	are	be	VBP
cord-002407-25cawzi0	162	12	administrated	administrate	VBN
cord-002407-25cawzi0	162	13	intranasally	intranasally	RB
cord-002407-25cawzi0	162	14	.	.	.
cord-002407-25cawzi0	163	1	The	the	DT
cord-002407-25cawzi0	163	2	advantages	advantage	NNS
cord-002407-25cawzi0	163	3	of	of	IN
cord-002407-25cawzi0	163	4	a	a	DT
cord-002407-25cawzi0	163	5	live	live	JJ
cord-002407-25cawzi0	163	6	virus	virus	NN
cord-002407-25cawzi0	163	7	vaccine	vaccine	NN
cord-002407-25cawzi0	163	8	,	,	,
cord-002407-25cawzi0	163	9	as	as	IN
cord-002407-25cawzi0	163	10	compared	compare	VBN
cord-002407-25cawzi0	163	11	to	to	IN
cord-002407-25cawzi0	163	12	the	the	DT
cord-002407-25cawzi0	163	13	inactivated	inactivate	VBN
cord-002407-25cawzi0	163	14	virus	virus	NN
cord-002407-25cawzi0	163	15	vaccine	vaccine	NN
cord-002407-25cawzi0	163	16	,	,	,
cord-002407-25cawzi0	163	17	is	be	VBZ
cord-002407-25cawzi0	163	18	that	that	IN
cord-002407-25cawzi0	163	19	it	-PRON-	PRP
cord-002407-25cawzi0	163	20	is	be	VBZ
cord-002407-25cawzi0	163	21	applied	apply	VBN
cord-002407-25cawzi0	163	22	to	to	IN
cord-002407-25cawzi0	163	23	the	the	DT
cord-002407-25cawzi0	163	24	nasal	nasal	NN
cord-002407-25cawzi0	163	25	mucosa	mucosa	NN
cord-002407-25cawzi0	163	26	where	where	WRB
cord-002407-25cawzi0	163	27	the	the	DT
cord-002407-25cawzi0	163	28	vaccine	vaccine	NN
cord-002407-25cawzi0	163	29	can	can	MD
cord-002407-25cawzi0	163	30	induce	induce	VB
cord-002407-25cawzi0	163	31	local	local	JJ
cord-002407-25cawzi0	163	32	immunity	immunity	NN
cord-002407-25cawzi0	163	33	(	(	-LRB-
cord-002407-25cawzi0	163	34	including	include	VBG
cord-002407-25cawzi0	163	35	NAbs	NAbs	NNP
cord-002407-25cawzi0	163	36	)	)	-RRB-
cord-002407-25cawzi0	163	37	,	,	,
cord-002407-25cawzi0	163	38	generate	generate	VBP
cord-002407-25cawzi0	163	39	a	a	DT
cord-002407-25cawzi0	163	40	cell	cell	NN
cord-002407-25cawzi0	163	41	-	-	HYPH
cord-002407-25cawzi0	163	42	mediated	mediate	VBN
cord-002407-25cawzi0	163	43	immune	immune	JJ
cord-002407-25cawzi0	163	44	response	response	NN
cord-002407-25cawzi0	163	45	and	and	CC
cord-002407-25cawzi0	163	46	provide	provide	VB
cord-002407-25cawzi0	163	47	a	a	DT
cord-002407-25cawzi0	163	48	cross	cross	JJ
cord-002407-25cawzi0	163	49	-	-	JJ
cord-002407-25cawzi0	163	50	reactive	reactive	JJ
cord-002407-25cawzi0	163	51	and	and	CC
cord-002407-25cawzi0	163	52	longer	long	RBR
cord-002407-25cawzi0	163	53	lasting	last	VBG
cord-002407-25cawzi0	163	54	immune	immune	JJ
cord-002407-25cawzi0	163	55	response	response	NN
cord-002407-25cawzi0	163	56	[	[	-LRB-
cord-002407-25cawzi0	163	57	106	106	CD
cord-002407-25cawzi0	163	58	]	]	-RRB-
cord-002407-25cawzi0	163	59	.	.	.
cord-002407-25cawzi0	164	1	The	the	DT
cord-002407-25cawzi0	164	2	current	current	JJ
cord-002407-25cawzi0	164	3	LAIVs	laiv	NNS
cord-002407-25cawzi0	164	4	consist	consist	VBP
cord-002407-25cawzi0	164	5	of	of	IN
cord-002407-25cawzi0	164	6	the	the	DT
cord-002407-25cawzi0	164	7	internal	internal	JJ
cord-002407-25cawzi0	164	8	viral	viral	JJ
cord-002407-25cawzi0	164	9	segments	segment	NNS
cord-002407-25cawzi0	164	10	(	(	-LRB-
cord-002407-25cawzi0	164	11	PB2	PB2	NNP
cord-002407-25cawzi0	164	12	,	,	,
cord-002407-25cawzi0	164	13	PB1	PB1	NNP
cord-002407-25cawzi0	164	14	,	,	,
cord-002407-25cawzi0	164	15	PA	PA	NNP
cord-002407-25cawzi0	164	16	,	,	,
cord-002407-25cawzi0	164	17	NP	NP	NNP
cord-002407-25cawzi0	164	18	,	,	,
cord-002407-25cawzi0	164	19	M	M	NNP
cord-002407-25cawzi0	164	20	and	and	CC
cord-002407-25cawzi0	164	21	NS	NS	NNP
cord-002407-25cawzi0	164	22	)	)	-RRB-
cord-002407-25cawzi0	164	23	of	of	IN
cord-002407-25cawzi0	164	24	an	an	DT
cord-002407-25cawzi0	164	25	attenuated	attenuated	JJ
cord-002407-25cawzi0	164	26	master	master	NN
cord-002407-25cawzi0	164	27	donor	donor	NN
cord-002407-25cawzi0	164	28	virus	virus	NN
cord-002407-25cawzi0	164	29	(	(	-LRB-
cord-002407-25cawzi0	164	30	MDV	MDV	NNP
cord-002407-25cawzi0	164	31	)	)	-RRB-
cord-002407-25cawzi0	164	32	and	and	CC
cord-002407-25cawzi0	164	33	the	the	DT
cord-002407-25cawzi0	164	34	HA	HA	NNP
cord-002407-25cawzi0	164	35	and	and	CC
cord-002407-25cawzi0	164	36	NA	NA	NNP
cord-002407-25cawzi0	164	37	viral	viral	JJ
cord-002407-25cawzi0	164	38	segments	segment	NNS
cord-002407-25cawzi0	164	39	from	from	IN
cord-002407-25cawzi0	164	40	the	the	DT
cord-002407-25cawzi0	164	41	selected	select	VBN
cord-002407-25cawzi0	164	42	seasonal	seasonal	JJ
cord-002407-25cawzi0	164	43	virus	virus	NN
cord-002407-25cawzi0	164	44	strain	strain	NN
cord-002407-25cawzi0	164	45	(	(	-LRB-
cord-002407-25cawzi0	164	46	Figure	figure	NN
cord-002407-25cawzi0	164	47	2B	2b	CD
cord-002407-25cawzi0	164	48	)	)	-RRB-
cord-002407-25cawzi0	164	49	.	.	.
cord-002407-25cawzi0	165	1	The	the	DT
cord-002407-25cawzi0	165	2	MDVs	mdv	NNS
cord-002407-25cawzi0	165	3	used	use	VBD
cord-002407-25cawzi0	165	4	are	be	VBP
cord-002407-25cawzi0	165	5	A	A	NNP
cord-002407-25cawzi0	165	6	/	/	SYM
cord-002407-25cawzi0	165	7	Ann	Ann	NNP
cord-002407-25cawzi0	165	8	Arbor/6/60	Arbor/6/60	NNP
cord-002407-25cawzi0	165	9	(	(	-LRB-
cord-002407-25cawzi0	165	10	H2N2	H2N2	NNP
cord-002407-25cawzi0	165	11	)	)	-RRB-
cord-002407-25cawzi0	165	12	and	and	CC
cord-002407-25cawzi0	165	13	B	B	NNP
cord-002407-25cawzi0	165	14	/	/	SYM
cord-002407-25cawzi0	165	15	Ann	Ann	NNP
cord-002407-25cawzi0	165	16	Arbor/1/66	Arbor/1/66	NNP
cord-002407-25cawzi0	165	17	for	for	IN
cord-002407-25cawzi0	165	18	IAV	IAV	NNP
cord-002407-25cawzi0	165	19	and	and	CC
cord-002407-25cawzi0	165	20	IBV	IBV	NNP
cord-002407-25cawzi0	165	21	,	,	,
cord-002407-25cawzi0	165	22	respectively	respectively	RB
cord-002407-25cawzi0	165	23	[	[	-LRB-
cord-002407-25cawzi0	165	24	103	103	CD
cord-002407-25cawzi0	165	25	,	,	,
cord-002407-25cawzi0	165	26	104	104	CD
cord-002407-25cawzi0	165	27	,	,	,
cord-002407-25cawzi0	165	28	[	[	-LRB-
cord-002407-25cawzi0	165	29	107	107	CD
cord-002407-25cawzi0	165	30	]	]	-RRB-
cord-002407-25cawzi0	165	31	[	[	-LRB-
cord-002407-25cawzi0	165	32	108	108	CD
cord-002407-25cawzi0	165	33	]	]	-RRB-
cord-002407-25cawzi0	165	34	[	[	-LRB-
cord-002407-25cawzi0	165	35	109	109	CD
cord-002407-25cawzi0	165	36	]	]	-RRB-
cord-002407-25cawzi0	165	37	[	[	-LRB-
cord-002407-25cawzi0	165	38	110	110	CD
cord-002407-25cawzi0	165	39	]	]	-RRB-
cord-002407-25cawzi0	165	40	[	[	-LRB-
cord-002407-25cawzi0	165	41	111	111	CD
cord-002407-25cawzi0	165	42	]	]	-RRB-
cord-002407-25cawzi0	165	43	[	[	-LRB-
cord-002407-25cawzi0	165	44	112	112	CD
cord-002407-25cawzi0	165	45	]	]	-RRB-
cord-002407-25cawzi0	165	46	[	[	-LRB-
cord-002407-25cawzi0	165	47	113	113	CD
cord-002407-25cawzi0	165	48	]	]	-RRB-
cord-002407-25cawzi0	165	49	.	.	.
cord-002407-25cawzi0	166	1	Similar	similar	JJ
cord-002407-25cawzi0	166	2	to	to	IN
cord-002407-25cawzi0	166	3	MDV	MDV	NNP
cord-002407-25cawzi0	166	4	IAV	IAV	NNP
cord-002407-25cawzi0	166	5	,	,	,
cord-002407-25cawzi0	166	6	MDV	MDV	NNP
cord-002407-25cawzi0	166	7	IBV	IBV	NNP
cord-002407-25cawzi0	166	8	was	be	VBD
cord-002407-25cawzi0	166	9	originally	originally	RB
cord-002407-25cawzi0	166	10	derived	derive	VBN
cord-002407-25cawzi0	166	11	by	by	IN
cord-002407-25cawzi0	166	12	serial	serial	JJ
cord-002407-25cawzi0	166	13	passage	passage	NN
cord-002407-25cawzi0	166	14	of	of	IN
cord-002407-25cawzi0	166	15	the	the	DT
cord-002407-25cawzi0	166	16	parental	parental	JJ
cord-002407-25cawzi0	166	17	WT	WT	NNP
cord-002407-25cawzi0	166	18	virus	virus	NN
cord-002407-25cawzi0	166	19	and	and	CC
cord-002407-25cawzi0	166	20	isolated	isolate	VBN
cord-002407-25cawzi0	166	21	at	at	IN
cord-002407-25cawzi0	166	22	successively	successively	RB
cord-002407-25cawzi0	166	23	reduced	reduce	VBN
cord-002407-25cawzi0	166	24	temperatures	temperature	NNS
cord-002407-25cawzi0	166	25	in	in	IN
cord-002407-25cawzi0	166	26	primary	primary	JJ
cord-002407-25cawzi0	166	27	chicken	chicken	NN
cord-002407-25cawzi0	166	28	kidney	kidney	NN
cord-002407-25cawzi0	166	29	(	(	-LRB-
cord-002407-25cawzi0	166	30	PCK	PCK	NNP
cord-002407-25cawzi0	166	31	)	)	-RRB-
cord-002407-25cawzi0	166	32	cells	cell	NNS
cord-002407-25cawzi0	166	33	[	[	-LRB-
cord-002407-25cawzi0	166	34	114	114	CD
cord-002407-25cawzi0	166	35	]	]	-RRB-
cord-002407-25cawzi0	166	36	.	.	.
cord-002407-25cawzi0	167	1	The	the	DT
cord-002407-25cawzi0	167	2	resulting	result	VBG
cord-002407-25cawzi0	167	3	IBV	IBV	NNP
cord-002407-25cawzi0	167	4	MDV	MDV	NNP
cord-002407-25cawzi0	167	5	grows	grow	VBZ
cord-002407-25cawzi0	167	6	efficiently	efficiently	RB
cord-002407-25cawzi0	167	7	at	at	IN
cord-002407-25cawzi0	167	8	25	25	CD
cord-002407-25cawzi0	167	9	•	•	NNS
cord-002407-25cawzi0	167	10	C	C	NNP
cord-002407-25cawzi0	167	11	(	(	-LRB-
cord-002407-25cawzi0	167	12	ca	ca	NNP
cord-002407-25cawzi0	167	13	)	)	-RRB-
cord-002407-25cawzi0	167	14	,	,	,
cord-002407-25cawzi0	167	15	but	but	CC
cord-002407-25cawzi0	167	16	its	-PRON-	PRP$
cord-002407-25cawzi0	167	17	growth	growth	NN
cord-002407-25cawzi0	167	18	is	be	VBZ
cord-002407-25cawzi0	167	19	restricted	restrict	VBN
cord-002407-25cawzi0	167	20	at	at	IN
cord-002407-25cawzi0	167	21	37	37	CD
cord-002407-25cawzi0	167	22	•	•	NN
cord-002407-25cawzi0	167	23	C	c	NN
cord-002407-25cawzi0	167	24	(	(	-LRB-
cord-002407-25cawzi0	167	25	ts	ts	NNP
cord-002407-25cawzi0	167	26	)	)	-RRB-
cord-002407-25cawzi0	167	27	.	.	.
cord-002407-25cawzi0	168	1	The	the	DT
cord-002407-25cawzi0	168	2	genetic	genetic	JJ
cord-002407-25cawzi0	168	3	changes	change	NNS
cord-002407-25cawzi0	168	4	in	in	IN
cord-002407-25cawzi0	168	5	the	the	DT
cord-002407-25cawzi0	168	6	MDV	MDV	NNP
cord-002407-25cawzi0	168	7	strains	strain	NNS
cord-002407-25cawzi0	168	8	have	have	VBP
cord-002407-25cawzi0	168	9	been	be	VBN
cord-002407-25cawzi0	168	10	recently	recently	RB
cord-002407-25cawzi0	168	11	characterized	characterize	VBN
cord-002407-25cawzi0	168	12	.	.	.
cord-002407-25cawzi0	169	1	The	the	DT
cord-002407-25cawzi0	169	2	MDV	MDV	NNP
cord-002407-25cawzi0	169	3	IAV	IAV	NNP
cord-002407-25cawzi0	169	4	includes	include	VBZ
cord-002407-25cawzi0	169	5	five	five	CD
cord-002407-25cawzi0	169	6	mutations	mutation	NNS
cord-002407-25cawzi0	169	7	in	in	IN
cord-002407-25cawzi0	169	8	two	two	CD
cord-002407-25cawzi0	169	9	of	of	IN
cord-002407-25cawzi0	169	10	the	the	DT
cord-002407-25cawzi0	169	11	viral	viral	JJ
cord-002407-25cawzi0	169	12	polymerases	polymerase	NNS
cord-002407-25cawzi0	169	13	(	(	-LRB-
cord-002407-25cawzi0	169	14	PB2	PB2	NNP
cord-002407-25cawzi0	169	15	N265S	n265s	NN
cord-002407-25cawzi0	169	16	;	;	:
cord-002407-25cawzi0	169	17	and	and	CC
cord-002407-25cawzi0	169	18	PB1	PB1	NNP
cord-002407-25cawzi0	169	19	K391E	K391E	NNP
cord-002407-25cawzi0	169	20	,	,	,
cord-002407-25cawzi0	169	21	D581	D581	NNP
cord-002407-25cawzi0	169	22	G	g	NN
cord-002407-25cawzi0	169	23	and	and	CC
cord-002407-25cawzi0	169	24	A661	A661	NNPS
cord-002407-25cawzi0	169	25	T	T	NNP
cord-002407-25cawzi0	169	26	)	)	-RRB-
cord-002407-25cawzi0	169	27	and	and	CC
cord-002407-25cawzi0	169	28	NP	NP	NNP
cord-002407-25cawzi0	169	29	(	(	-LRB-
cord-002407-25cawzi0	169	30	D34	D34	NNP
cord-002407-25cawzi0	169	31	G	G	NNP
cord-002407-25cawzi0	169	32	)	)	-RRB-
cord-002407-25cawzi0	169	33	[	[	-LRB-
cord-002407-25cawzi0	169	34	103	103	CD
cord-002407-25cawzi0	169	35	,	,	,
cord-002407-25cawzi0	169	36	104	104	CD
cord-002407-25cawzi0	169	37	,	,	,
cord-002407-25cawzi0	169	38	115	115	CD
cord-002407-25cawzi0	169	39	]	]	-RRB-
cord-002407-25cawzi0	169	40	.	.	.
cord-002407-25cawzi0	170	1	The	the	DT
cord-002407-25cawzi0	170	2	MDV	MDV	NNP
cord-002407-25cawzi0	170	3	IBV	IBV	NNP
cord-002407-25cawzi0	170	4	has	have	VBZ
cord-002407-25cawzi0	170	5	been	be	VBN
cord-002407-25cawzi0	170	6	reported	report	VBN
cord-002407-25cawzi0	170	7	to	to	TO
cord-002407-25cawzi0	170	8	contain	contain	VB
cord-002407-25cawzi0	170	9	two	two	CD
cord-002407-25cawzi0	170	10	mutant	mutant	JJ
cord-002407-25cawzi0	170	11	amino	amino	NN
cord-002407-25cawzi0	170	12	acids	acid	NNS
cord-002407-25cawzi0	170	13	in	in	IN
cord-002407-25cawzi0	170	14	NP	NP	NNP
cord-002407-25cawzi0	170	15	(	(	-LRB-
cord-002407-25cawzi0	170	16	A114	A114	NNPS
cord-002407-25cawzi0	170	17	and	and	CC
cord-002407-25cawzi0	170	18	H410	H410	NNPS
cord-002407-25cawzi0	170	19	)	)	-RRB-
cord-002407-25cawzi0	170	20	and	and	CC
cord-002407-25cawzi0	170	21	one	one	CD
cord-002407-25cawzi0	170	22	in	in	IN
cord-002407-25cawzi0	170	23	PA	PA	NNP
cord-002407-25cawzi0	170	24	(	(	-LRB-
cord-002407-25cawzi0	170	25	M431	M431	NNP
cord-002407-25cawzi0	170	26	)	)	-RRB-
cord-002407-25cawzi0	170	27	that	that	WDT
cord-002407-25cawzi0	170	28	are	be	VBP
cord-002407-25cawzi0	170	29	responsible	responsible	JJ
cord-002407-25cawzi0	170	30	for	for	IN
cord-002407-25cawzi0	170	31	the	the	DT
cord-002407-25cawzi0	170	32	ts	ts	NNPS
cord-002407-25cawzi0	170	33	,	,	,
cord-002407-25cawzi0	170	34	ca	ca	MD
cord-002407-25cawzi0	170	35	signature	signature	VB
cord-002407-25cawzi0	170	36	[	[	-LRB-
cord-002407-25cawzi0	170	37	108	108	CD
cord-002407-25cawzi0	170	38	]	]	-RRB-
cord-002407-25cawzi0	170	39	.	.	.
cord-002407-25cawzi0	171	1	Two	two	CD
cord-002407-25cawzi0	171	2	additional	additional	JJ
cord-002407-25cawzi0	171	3	residues	residue	NNS
cord-002407-25cawzi0	171	4	in	in	IN
cord-002407-25cawzi0	171	5	M1	M1	NNP
cord-002407-25cawzi0	171	6	(	(	-LRB-
cord-002407-25cawzi0	171	7	Q159	Q159	NNP
cord-002407-25cawzi0	171	8	and	and	CC
cord-002407-25cawzi0	171	9	V183	V183	NNP
cord-002407-25cawzi0	171	10	)	)	-RRB-
cord-002407-25cawzi0	171	11	provide	provide	VB
cord-002407-25cawzi0	171	12	the	the	DT
cord-002407-25cawzi0	171	13	MDV	MDV	NNP
cord-002407-25cawzi0	171	14	IBV	IBV	NNP
cord-002407-25cawzi0	171	15	an	an	DT
cord-002407-25cawzi0	171	16	attenuated	attenuated	JJ
cord-002407-25cawzi0	171	17	(	(	-LRB-
cord-002407-25cawzi0	171	18	att	att	NNP
cord-002407-25cawzi0	171	19	)	)	-RRB-
cord-002407-25cawzi0	171	20	phenotype	phenotype	NN
cord-002407-25cawzi0	171	21	[	[	-LRB-
cord-002407-25cawzi0	171	22	108	108	CD
cord-002407-25cawzi0	171	23	]	]	-RRB-
cord-002407-25cawzi0	171	24	.	.	.
cord-002407-25cawzi0	172	1	Although	although	IN
cord-002407-25cawzi0	172	2	LAIVs	laiv	NNS
cord-002407-25cawzi0	172	3	have	have	VBP
cord-002407-25cawzi0	172	4	been	be	VBN
cord-002407-25cawzi0	172	5	approved	approve	VBN
cord-002407-25cawzi0	172	6	for	for	IN
cord-002407-25cawzi0	172	7	clinical	clinical	JJ
cord-002407-25cawzi0	172	8	use	use	NN
cord-002407-25cawzi0	172	9	,	,	,
cord-002407-25cawzi0	172	10	to	to	IN
cord-002407-25cawzi0	172	11	date	date	NN
cord-002407-25cawzi0	172	12	,	,	,
cord-002407-25cawzi0	172	13	their	-PRON-	PRP$
cord-002407-25cawzi0	172	14	mechanism	mechanism	NN
cord-002407-25cawzi0	172	15	of	of	IN
cord-002407-25cawzi0	172	16	attenuation	attenuation	NN
cord-002407-25cawzi0	172	17	has	have	VBZ
cord-002407-25cawzi0	172	18	not	not	RB
cord-002407-25cawzi0	172	19	been	be	VBN
cord-002407-25cawzi0	172	20	completely	completely	RB
cord-002407-25cawzi0	172	21	understood	understand	VBN
cord-002407-25cawzi0	172	22	.	.	.
cord-002407-25cawzi0	173	1	However	however	RB
cord-002407-25cawzi0	173	2	,	,	,
cord-002407-25cawzi0	173	3	the	the	DT
cord-002407-25cawzi0	173	4	tolerability	tolerability	NN
cord-002407-25cawzi0	173	5	of	of	IN
cord-002407-25cawzi0	173	6	LAIVs	laiv	NNS
cord-002407-25cawzi0	173	7	in	in	IN
cord-002407-25cawzi0	173	8	specific	specific	JJ
cord-002407-25cawzi0	173	9	populations	population	NNS
cord-002407-25cawzi0	173	10	is	be	VBZ
cord-002407-25cawzi0	173	11	an	an	DT
cord-002407-25cawzi0	173	12	important	important	JJ
cord-002407-25cawzi0	173	13	concern	concern	NN
cord-002407-25cawzi0	173	14	because	because	IN
cord-002407-25cawzi0	173	15	of	of	IN
cord-002407-25cawzi0	173	16	the	the	DT
cord-002407-25cawzi0	173	17	inherent	inherent	JJ
cord-002407-25cawzi0	173	18	risk	risk	NN
cord-002407-25cawzi0	173	19	of	of	IN
cord-002407-25cawzi0	173	20	immunizing	immunize	VBG
cord-002407-25cawzi0	173	21	with	with	IN
cord-002407-25cawzi0	173	22	live	live	JJ
cord-002407-25cawzi0	173	23	viruses	virus	NNS
cord-002407-25cawzi0	173	24	.	.	.
cord-002407-25cawzi0	174	1	Thus	thus	RB
cord-002407-25cawzi0	174	2	,	,	,
cord-002407-25cawzi0	174	3	LAIVs	laiv	NNS
cord-002407-25cawzi0	174	4	are	be	VBP
cord-002407-25cawzi0	174	5	not	not	RB
cord-002407-25cawzi0	174	6	recommended	recommend	VBN
cord-002407-25cawzi0	174	7	for	for	IN
cord-002407-25cawzi0	174	8	immunocompromised	immunocompromised	JJ
cord-002407-25cawzi0	174	9	patients	patient	NNS
cord-002407-25cawzi0	174	10	or	or	CC
cord-002407-25cawzi0	174	11	asthmatics	asthmatic	NNS
cord-002407-25cawzi0	174	12	[	[	-LRB-
cord-002407-25cawzi0	174	13	116	116	CD
cord-002407-25cawzi0	174	14	]	]	-RRB-
cord-002407-25cawzi0	174	15	and	and	CC
cord-002407-25cawzi0	174	16	are	be	VBP
cord-002407-25cawzi0	174	17	not	not	RB
cord-002407-25cawzi0	174	18	approved	approve	VBN
cord-002407-25cawzi0	174	19	for	for	IN
cord-002407-25cawzi0	174	20	use	use	NN
cord-002407-25cawzi0	174	21	in	in	IN
cord-002407-25cawzi0	174	22	children	child	NNS
cord-002407-25cawzi0	174	23	under	under	IN
cord-002407-25cawzi0	174	24	two	two	CD
cord-002407-25cawzi0	174	25	years	year	NNS
cord-002407-25cawzi0	174	26	of	of	IN
cord-002407-25cawzi0	174	27	age	age	NN
cord-002407-25cawzi0	174	28	[	[	-LRB-
cord-002407-25cawzi0	174	29	72	72	CD
cord-002407-25cawzi0	174	30	,	,	,
cord-002407-25cawzi0	174	31	117	117	CD
cord-002407-25cawzi0	174	32	]	]	-RRB-
cord-002407-25cawzi0	174	33	.	.	.
cord-002407-25cawzi0	175	1	Moreover	moreover	RB
cord-002407-25cawzi0	175	2	,	,	,
cord-002407-25cawzi0	175	3	LAIVs	laiv	NNS
cord-002407-25cawzi0	175	4	harboring	harbor	VBG
cord-002407-25cawzi0	175	5	different	different	JJ
cord-002407-25cawzi0	175	6	HA	HA	NNP
cord-002407-25cawzi0	175	7	and	and	CC
cord-002407-25cawzi0	175	8	NA	NA	NNP
cord-002407-25cawzi0	175	9	viral	viral	JJ
cord-002407-25cawzi0	175	10	segments	segment	NNS
cord-002407-25cawzi0	175	11	can	can	MD
cord-002407-25cawzi0	175	12	be	be	VB
cord-002407-25cawzi0	175	13	unequally	unequally	RB
cord-002407-25cawzi0	175	14	safe	safe	JJ
cord-002407-25cawzi0	175	15	or	or	CC
cord-002407-25cawzi0	175	16	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	175	17	from	from	IN
cord-002407-25cawzi0	175	18	year	year	NN
cord-002407-25cawzi0	175	19	to	to	IN
cord-002407-25cawzi0	175	20	year	year	NN
cord-002407-25cawzi0	175	21	as	as	IN
cord-002407-25cawzi0	175	22	the	the	DT
cord-002407-25cawzi0	175	23	viral	viral	JJ
cord-002407-25cawzi0	175	24	HA	HA	NNP
cord-002407-25cawzi0	175	25	and	and	CC
cord-002407-25cawzi0	175	26	NA	NA	NNP
cord-002407-25cawzi0	175	27	are	be	VBP
cord-002407-25cawzi0	175	28	different	different	JJ
cord-002407-25cawzi0	175	29	.	.	.
cord-002407-25cawzi0	176	1	Similar	similar	JJ
cord-002407-25cawzi0	176	2	to	to	IN
cord-002407-25cawzi0	176	3	U.S.	U.S.	NNP
cord-002407-25cawzi0	176	4	LAIVs	laiv	NNS
cord-002407-25cawzi0	176	5	,	,	,
cord-002407-25cawzi0	176	6	in	in	IN
cord-002407-25cawzi0	176	7	Russia	Russia	NNP
cord-002407-25cawzi0	176	8	,	,	,
cord-002407-25cawzi0	176	9	two	two	CD
cord-002407-25cawzi0	176	10	ts	t	NNS
cord-002407-25cawzi0	176	11	,	,	,
cord-002407-25cawzi0	176	12	ca	ca	NNP
cord-002407-25cawzi0	176	13	MDV	MDV	NNP
cord-002407-25cawzi0	176	14	IAVs	iav	NNS
cord-002407-25cawzi0	176	15	have	have	VBP
cord-002407-25cawzi0	176	16	been	be	VBN
cord-002407-25cawzi0	176	17	obtained	obtain	VBN
cord-002407-25cawzi0	176	18	by	by	IN
cord-002407-25cawzi0	176	19	using	use	VBG
cord-002407-25cawzi0	176	20	a	a	DT
cord-002407-25cawzi0	176	21	similar	similar	JJ
cord-002407-25cawzi0	176	22	temperature	temperature	NN
cord-002407-25cawzi0	176	23	adaptation	adaptation	NN
cord-002407-25cawzi0	176	24	approach	approach	NN
cord-002407-25cawzi0	176	25	.	.	.
cord-002407-25cawzi0	177	1	The	the	DT
cord-002407-25cawzi0	177	2	two	two	CD
cord-002407-25cawzi0	177	3	Russian	russian	JJ
cord-002407-25cawzi0	177	4	MDVs	mdv	NNS
cord-002407-25cawzi0	177	5	were	be	VBD
cord-002407-25cawzi0	177	6	originated	originate	VBN
cord-002407-25cawzi0	177	7	from	from	IN
cord-002407-25cawzi0	177	8	the	the	DT
cord-002407-25cawzi0	177	9	same	same	JJ
cord-002407-25cawzi0	177	10	parental	parental	JJ
cord-002407-25cawzi0	177	11	A	A	NNP
cord-002407-25cawzi0	177	12	/	/	SYM
cord-002407-25cawzi0	177	13	Leningrad/134/57	Leningrad/134/57	NNP
cord-002407-25cawzi0	177	14	H2N2	H2N2	NNP
cord-002407-25cawzi0	177	15	(	(	-LRB-
cord-002407-25cawzi0	177	16	Len/57	Len/57	NNP
cord-002407-25cawzi0	177	17	)	)	-RRB-
cord-002407-25cawzi0	177	18	influenza	influenza	NN
cord-002407-25cawzi0	177	19	strain	strain	VB
cord-002407-25cawzi0	177	20	[	[	-LRB-
cord-002407-25cawzi0	177	21	118	118	CD
cord-002407-25cawzi0	177	22	,	,	,
cord-002407-25cawzi0	177	23	119	119	CD
cord-002407-25cawzi0	177	24	]	]	-RRB-
cord-002407-25cawzi0	177	25	.	.	.
cord-002407-25cawzi0	178	1	Similarly	similarly	RB
cord-002407-25cawzi0	178	2	to	to	IN
cord-002407-25cawzi0	178	3	the	the	DT
cord-002407-25cawzi0	178	4	U.S.	U.S.	NNP
cord-002407-25cawzi0	178	5	MDV	MDV	NNP
cord-002407-25cawzi0	178	6	,	,	,
cord-002407-25cawzi0	178	7	the	the	DT
cord-002407-25cawzi0	178	8	Russian	russian	JJ
cord-002407-25cawzi0	178	9	MDVs	mdv	NNS
cord-002407-25cawzi0	178	10	have	have	VBP
cord-002407-25cawzi0	178	11	been	be	VBN
cord-002407-25cawzi0	178	12	selected	select	VBN
cord-002407-25cawzi0	178	13	by	by	IN
cord-002407-25cawzi0	178	14	growing	grow	VBG
cord-002407-25cawzi0	178	15	Len/57	len/57	NN
cord-002407-25cawzi0	178	16	in	in	IN
cord-002407-25cawzi0	178	17	embryonated	embryonate	VBN
cord-002407-25cawzi0	178	18	chicken	chicken	NN
cord-002407-25cawzi0	178	19	eggs	egg	NNS
cord-002407-25cawzi0	178	20	at	at	IN
cord-002407-25cawzi0	178	21	lower	low	JJR
cord-002407-25cawzi0	178	22	(	(	-LRB-
cord-002407-25cawzi0	178	23	25	25	CD
cord-002407-25cawzi0	178	24	•	•	NN
cord-002407-25cawzi0	178	25	C	c	NN
cord-002407-25cawzi0	178	26	)	)	-RRB-
cord-002407-25cawzi0	178	27	temperatures	temperature	NNS
cord-002407-25cawzi0	178	28	.	.	.
cord-002407-25cawzi0	179	1	The	the	DT
cord-002407-25cawzi0	179	2	MDV	MDV	NNP
cord-002407-25cawzi0	179	3	Len/17	Len/17	VBD
cord-002407-25cawzi0	179	4	was	be	VBD
cord-002407-25cawzi0	179	5	obtained	obtain	VBN
cord-002407-25cawzi0	179	6	after	after	IN
cord-002407-25cawzi0	179	7	17	17	CD
cord-002407-25cawzi0	179	8	passages	passage	NNS
cord-002407-25cawzi0	179	9	of	of	IN
cord-002407-25cawzi0	179	10	Len/57	len/57	NN
cord-002407-25cawzi0	179	11	at	at	IN
cord-002407-25cawzi0	179	12	25	25	CD
cord-002407-25cawzi0	180	1	•	•	NNP
cord-002407-25cawzi0	180	2	C	C	NNP
cord-002407-25cawzi0	180	3	and	and	CC
cord-002407-25cawzi0	180	4	has	have	VBZ
cord-002407-25cawzi0	180	5	been	be	VBN
cord-002407-25cawzi0	180	6	used	use	VBN
cord-002407-25cawzi0	180	7	in	in	IN
cord-002407-25cawzi0	180	8	the	the	DT
cord-002407-25cawzi0	180	9	preparation	preparation	NN
cord-002407-25cawzi0	180	10	of	of	IN
cord-002407-25cawzi0	180	11	the	the	DT
cord-002407-25cawzi0	180	12	Russian	russian	JJ
cord-002407-25cawzi0	180	13	LAIV	LAIV	NNP
cord-002407-25cawzi0	180	14	for	for	IN
cord-002407-25cawzi0	180	15	use	use	NN
cord-002407-25cawzi0	180	16	in	in	IN
cord-002407-25cawzi0	180	17	adults	adult	NNS
cord-002407-25cawzi0	180	18	.	.	.
cord-002407-25cawzi0	181	1	The	the	DT
cord-002407-25cawzi0	181	2	genetic	genetic	JJ
cord-002407-25cawzi0	181	3	changes	change	NNS
cord-002407-25cawzi0	181	4	in	in	IN
cord-002407-25cawzi0	181	5	the	the	DT
cord-002407-25cawzi0	181	6	MDVs	mdv	NNS
cord-002407-25cawzi0	181	7	Len/17	Len/17	VBD
cord-002407-25cawzi0	181	8	have	have	VBP
cord-002407-25cawzi0	181	9	been	be	VBN
cord-002407-25cawzi0	181	10	identified	identify	VBN
cord-002407-25cawzi0	181	11	,	,	,
cord-002407-25cawzi0	181	12	and	and	CC
cord-002407-25cawzi0	181	13	these	these	DT
cord-002407-25cawzi0	181	14	include	include	VBP
cord-002407-25cawzi0	181	15	four	four	CD
cord-002407-25cawzi0	181	16	mutations	mutation	NNS
cord-002407-25cawzi0	181	17	in	in	IN
cord-002407-25cawzi0	181	18	three	three	CD
cord-002407-25cawzi0	181	19	viral	viral	JJ
cord-002407-25cawzi0	181	20	proteins	protein	NNS
cord-002407-25cawzi0	181	21	(	(	-LRB-
cord-002407-25cawzi0	181	22	PB2	PB2	NNP
cord-002407-25cawzi0	181	23	V478L	V478L	NNP
cord-002407-25cawzi0	181	24	;	;	:
cord-002407-25cawzi0	181	25	PB1	pb1	JJ
cord-002407-25cawzi0	181	26	K265N	K265N	NNP
cord-002407-25cawzi0	181	27	and	and	CC
cord-002407-25cawzi0	181	28	V591I	V591I	NNP
cord-002407-25cawzi0	181	29	;	;	:
cord-002407-25cawzi0	181	30	NEP	NEP	NNP
cord-002407-25cawzi0	181	31	M100I	M100I	NNP
cord-002407-25cawzi0	181	32	)	)	-RRB-
cord-002407-25cawzi0	181	33	[	[	-LRB-
cord-002407-25cawzi0	181	34	120	120	CD
cord-002407-25cawzi0	181	35	]	]	-RRB-
cord-002407-25cawzi0	181	36	.	.	.
cord-002407-25cawzi0	182	1	The	the	DT
cord-002407-25cawzi0	182	2	second	second	JJ
cord-002407-25cawzi0	182	3	donor	donor	NN
cord-002407-25cawzi0	182	4	strain	strain	NN
cord-002407-25cawzi0	182	5	(	(	-LRB-
cord-002407-25cawzi0	182	6	Len/47	len/47	NN
cord-002407-25cawzi0	182	7	)	)	-RRB-
cord-002407-25cawzi0	182	8	was	be	VBD
cord-002407-25cawzi0	182	9	obtained	obtain	VBN
cord-002407-25cawzi0	182	10	after	after	IN
cord-002407-25cawzi0	182	11	a	a	DT
cord-002407-25cawzi0	182	12	total	total	NN
cord-002407-25cawzi0	182	13	of	of	IN
cord-002407-25cawzi0	182	14	47	47	CD
cord-002407-25cawzi0	182	15	passages	passage	NNS
cord-002407-25cawzi0	182	16	and	and	CC
cord-002407-25cawzi0	182	17	has	have	VBZ
cord-002407-25cawzi0	182	18	been	be	VBN
cord-002407-25cawzi0	182	19	used	use	VBN
cord-002407-25cawzi0	182	20	for	for	IN
cord-002407-25cawzi0	182	21	vaccinating	vaccinate	VBG
cord-002407-25cawzi0	182	22	children	child	NNS
cord-002407-25cawzi0	182	23	less	less	JJR
cord-002407-25cawzi0	182	24	than	than	IN
cord-002407-25cawzi0	182	25	16	16	CD
cord-002407-25cawzi0	182	26	years	year	NNS
cord-002407-25cawzi0	182	27	of	of	IN
cord-002407-25cawzi0	182	28	age	age	NN
cord-002407-25cawzi0	182	29	,	,	,
cord-002407-25cawzi0	182	30	although	although	IN
cord-002407-25cawzi0	182	31	the	the	DT
cord-002407-25cawzi0	182	32	genetic	genetic	JJ
cord-002407-25cawzi0	182	33	changes	change	NNS
cord-002407-25cawzi0	182	34	responsible	responsible	JJ
cord-002407-25cawzi0	182	35	for	for	IN
cord-002407-25cawzi0	182	36	the	the	DT
cord-002407-25cawzi0	182	37	further	further	JJ
cord-002407-25cawzi0	182	38	ts	ts	NN
cord-002407-25cawzi0	182	39	,	,	,
cord-002407-25cawzi0	182	40	ca	ca	MD
cord-002407-25cawzi0	182	41	phenotype	phenotype	NN
cord-002407-25cawzi0	182	42	have	have	VBP
cord-002407-25cawzi0	182	43	not	not	RB
cord-002407-25cawzi0	182	44	been	be	VBN
cord-002407-25cawzi0	182	45	well	well	RB
cord-002407-25cawzi0	182	46	characterized	characterize	VBN
cord-002407-25cawzi0	182	47	[	[	-LRB-
cord-002407-25cawzi0	182	48	121	121	CD
cord-002407-25cawzi0	182	49	]	]	-RRB-
cord-002407-25cawzi0	182	50	.	.	.
cord-002407-25cawzi0	183	1	In	in	IN
cord-002407-25cawzi0	183	2	all	all	DT
cord-002407-25cawzi0	183	3	cases	case	NNS
cord-002407-25cawzi0	183	4	,	,	,
cord-002407-25cawzi0	183	5	like	like	IN
cord-002407-25cawzi0	183	6	for	for	IN
cord-002407-25cawzi0	183	7	IIV	IIV	NNP
cord-002407-25cawzi0	183	8	,	,	,
cord-002407-25cawzi0	183	9	the	the	DT
cord-002407-25cawzi0	183	10	MDVs	mdv	NNS
cord-002407-25cawzi0	183	11	contain	contain	VBP
cord-002407-25cawzi0	183	12	six	six	CD
cord-002407-25cawzi0	183	13	internal	internal	JJ
cord-002407-25cawzi0	183	14	genes	gene	NNS
cord-002407-25cawzi0	183	15	to	to	TO
cord-002407-25cawzi0	183	16	generate	generate	VB
cord-002407-25cawzi0	183	17	vaccine	vaccine	NN
cord-002407-25cawzi0	183	18	strains	strain	NNS
cord-002407-25cawzi0	183	19	in	in	IN
cord-002407-25cawzi0	183	20	combination	combination	NN
cord-002407-25cawzi0	183	21	with	with	IN
cord-002407-25cawzi0	183	22	the	the	DT
cord-002407-25cawzi0	183	23	seasonal	seasonal	JJ
cord-002407-25cawzi0	183	24	recommended	recommend	VBN
cord-002407-25cawzi0	183	25	HA	HA	NNP
cord-002407-25cawzi0	183	26	and	and	CC
cord-002407-25cawzi0	183	27	NA	NA	NNP
cord-002407-25cawzi0	183	28	genes	gene	NNS
cord-002407-25cawzi0	183	29	from	from	IN
cord-002407-25cawzi0	183	30	the	the	DT
cord-002407-25cawzi0	183	31	circulating	circulate	VBG
cord-002407-25cawzi0	183	32	strains	strain	NNS
cord-002407-25cawzi0	183	33	(	(	-LRB-
cord-002407-25cawzi0	183	34	Figure	figure	NN
cord-002407-25cawzi0	183	35	2B	2b	CD
cord-002407-25cawzi0	183	36	)	)	-RRB-
cord-002407-25cawzi0	183	37	.	.	.
cord-002407-25cawzi0	184	1	LAIVs	laiv	NNS
cord-002407-25cawzi0	184	2	are	be	VBP
cord-002407-25cawzi0	184	3	generated	generate	VBN
cord-002407-25cawzi0	184	4	either	either	CC
cord-002407-25cawzi0	184	5	by	by	IN
cord-002407-25cawzi0	184	6	classical	classical	JJ
cord-002407-25cawzi0	184	7	reassortment	reassortment	NN
cord-002407-25cawzi0	184	8	in	in	IN
cord-002407-25cawzi0	184	9	eggs	egg	NNS
cord-002407-25cawzi0	184	10	(	(	-LRB-
cord-002407-25cawzi0	184	11	as	as	IN
cord-002407-25cawzi0	184	12	previously	previously	RB
cord-002407-25cawzi0	184	13	described	describe	VBN
cord-002407-25cawzi0	184	14	for	for	IN
cord-002407-25cawzi0	184	15	the	the	DT
cord-002407-25cawzi0	184	16	IIV	IIV	NNP
cord-002407-25cawzi0	184	17	)	)	-RRB-
cord-002407-25cawzi0	184	18	(	(	-LRB-
cord-002407-25cawzi0	184	19	Figure	figure	NN
cord-002407-25cawzi0	184	20	2B	2b	CD
cord-002407-25cawzi0	184	21	)	)	-RRB-
cord-002407-25cawzi0	184	22	or	or	CC
cord-002407-25cawzi0	184	23	by	by	IN
cord-002407-25cawzi0	184	24	reverse	reverse	JJ
cord-002407-25cawzi0	184	25	genetics	genetic	NNS
cord-002407-25cawzi0	184	26	,	,	,
cord-002407-25cawzi0	184	27	as	as	IN
cord-002407-25cawzi0	184	28	indicated	indicate	VBN
cord-002407-25cawzi0	184	29	below	below	IN
cord-002407-25cawzi0	184	30	[	[	-LRB-
cord-002407-25cawzi0	184	31	98	98	CD
cord-002407-25cawzi0	184	32	]	]	-RRB-
cord-002407-25cawzi0	184	33	.	.	.
cord-002407-25cawzi0	185	1	Most	Most	JJS
cord-002407-25cawzi0	185	2	of	of	IN
cord-002407-25cawzi0	185	3	the	the	DT
cord-002407-25cawzi0	185	4	influenza	influenza	NN
cord-002407-25cawzi0	185	5	virus	virus	NN
cord-002407-25cawzi0	185	6	vaccines	vaccine	NNS
cord-002407-25cawzi0	185	7	have	have	VBP
cord-002407-25cawzi0	185	8	been	be	VBN
cord-002407-25cawzi0	185	9	traditionally	traditionally	RB
cord-002407-25cawzi0	185	10	produced	produce	VBN
cord-002407-25cawzi0	185	11	in	in	IN
cord-002407-25cawzi0	185	12	eggs	egg	NNS
cord-002407-25cawzi0	185	13	,	,	,
cord-002407-25cawzi0	185	14	but	but	CC
cord-002407-25cawzi0	185	15	with	with	IN
cord-002407-25cawzi0	185	16	the	the	DT
cord-002407-25cawzi0	185	17	progress	progress	NN
cord-002407-25cawzi0	185	18	made	make	VBN
cord-002407-25cawzi0	185	19	in	in	IN
cord-002407-25cawzi0	185	20	mammalian	mammalian	JJ
cord-002407-25cawzi0	185	21	cell	cell	NN
cord-002407-25cawzi0	185	22	culture	culture	NN
cord-002407-25cawzi0	185	23	technologies	technology	NNS
cord-002407-25cawzi0	185	24	,	,	,
cord-002407-25cawzi0	185	25	influenza	influenza	NN
cord-002407-25cawzi0	185	26	vaccine	vaccine	NN
cord-002407-25cawzi0	185	27	manufacturers	manufacturer	NNS
cord-002407-25cawzi0	185	28	have	have	VBP
cord-002407-25cawzi0	185	29	invested	invest	VBN
cord-002407-25cawzi0	185	30	in	in	IN
cord-002407-25cawzi0	185	31	these	these	DT
cord-002407-25cawzi0	185	32	novel	novel	JJ
cord-002407-25cawzi0	185	33	cell	cell	NN
cord-002407-25cawzi0	185	34	culture	culture	NN
cord-002407-25cawzi0	185	35	systems	system	NNS
cord-002407-25cawzi0	185	36	for	for	IN
cord-002407-25cawzi0	185	37	the	the	DT
cord-002407-25cawzi0	185	38	mass	mass	NN
cord-002407-25cawzi0	185	39	production	production	NN
cord-002407-25cawzi0	185	40	of	of	IN
cord-002407-25cawzi0	185	41	influenza	influenza	NN
cord-002407-25cawzi0	185	42	vaccines	vaccine	NNS
cord-002407-25cawzi0	185	43	without	without	IN
cord-002407-25cawzi0	185	44	the	the	DT
cord-002407-25cawzi0	185	45	need	need	NN
cord-002407-25cawzi0	185	46	of	of	IN
cord-002407-25cawzi0	185	47	eggs	egg	NNS
cord-002407-25cawzi0	185	48	.	.	.
cord-002407-25cawzi0	186	1	The	the	DT
cord-002407-25cawzi0	186	2	majority	majority	NN
cord-002407-25cawzi0	186	3	of	of	IN
cord-002407-25cawzi0	186	4	the	the	DT
cord-002407-25cawzi0	186	5	currently	currently	RB
cord-002407-25cawzi0	186	6	licensed	license	VBN
cord-002407-25cawzi0	186	7	influenza	influenza	NN
cord-002407-25cawzi0	186	8	vaccines	vaccine	NNS
cord-002407-25cawzi0	186	9	that	that	WDT
cord-002407-25cawzi0	186	10	are	be	VBP
cord-002407-25cawzi0	186	11	made	make	VBN
cord-002407-25cawzi0	186	12	by	by	IN
cord-002407-25cawzi0	186	13	biotechnology	biotechnology	NN
cord-002407-25cawzi0	186	14	companies	company	NNS
cord-002407-25cawzi0	186	15	use	use	VBP
cord-002407-25cawzi0	186	16	fertilized	fertilize	VBN
cord-002407-25cawzi0	186	17	chicken	chicken	NN
cord-002407-25cawzi0	186	18	egg	egg	NN
cord-002407-25cawzi0	186	19	-	-	HYPH
cord-002407-25cawzi0	186	20	based	base	VBN
cord-002407-25cawzi0	186	21	production	production	NN
cord-002407-25cawzi0	186	22	technology	technology	NN
cord-002407-25cawzi0	186	23	,	,	,
cord-002407-25cawzi0	186	24	but	but	CC
cord-002407-25cawzi0	186	25	this	this	DT
cord-002407-25cawzi0	186	26	process	process	NN
cord-002407-25cawzi0	186	27	has	have	VBZ
cord-002407-25cawzi0	186	28	multiple	multiple	JJ
cord-002407-25cawzi0	186	29	drawbacks	drawback	NNS
cord-002407-25cawzi0	186	30	.	.	.
cord-002407-25cawzi0	187	1	This	this	DT
cord-002407-25cawzi0	187	2	form	form	NN
cord-002407-25cawzi0	187	3	of	of	IN
cord-002407-25cawzi0	187	4	manufacturing	manufacturing	NN
cord-002407-25cawzi0	187	5	depends	depend	VBZ
cord-002407-25cawzi0	187	6	on	on	IN
cord-002407-25cawzi0	187	7	the	the	DT
cord-002407-25cawzi0	187	8	access	access	NN
cord-002407-25cawzi0	187	9	to	to	IN
cord-002407-25cawzi0	187	10	embryonated	embryonate	VBN
cord-002407-25cawzi0	187	11	eggs	egg	NNS
cord-002407-25cawzi0	187	12	,	,	,
cord-002407-25cawzi0	187	13	relies	rely	VBZ
cord-002407-25cawzi0	187	14	on	on	IN
cord-002407-25cawzi0	187	15	the	the	DT
cord-002407-25cawzi0	187	16	ability	ability	NN
cord-002407-25cawzi0	187	17	of	of	IN
cord-002407-25cawzi0	187	18	influenza	influenza	NN
cord-002407-25cawzi0	187	19	viruses	virus	NNS
cord-002407-25cawzi0	187	20	to	to	TO
cord-002407-25cawzi0	187	21	efficiently	efficiently	RB
cord-002407-25cawzi0	187	22	grow	grow	VB
cord-002407-25cawzi0	187	23	in	in	IN
cord-002407-25cawzi0	187	24	eggs	egg	NNS
cord-002407-25cawzi0	187	25	and	and	CC
cord-002407-25cawzi0	187	26	is	be	VBZ
cord-002407-25cawzi0	187	27	a	a	DT
cord-002407-25cawzi0	187	28	resource	resource	NN
cord-002407-25cawzi0	187	29	-	-	HYPH
cord-002407-25cawzi0	187	30	and	and	CC
cord-002407-25cawzi0	187	31	time	time	NN
cord-002407-25cawzi0	187	32	-	-	HYPH
cord-002407-25cawzi0	187	33	intensive	intensive	JJ
cord-002407-25cawzi0	187	34	process	process	NN
cord-002407-25cawzi0	187	35	[	[	-LRB-
cord-002407-25cawzi0	187	36	91	91	CD
cord-002407-25cawzi0	187	37	,	,	,
cord-002407-25cawzi0	187	38	[	[	-LRB-
cord-002407-25cawzi0	187	39	122	122	CD
cord-002407-25cawzi0	187	40	]	]	-RRB-
cord-002407-25cawzi0	187	41	[	[	-LRB-
cord-002407-25cawzi0	187	42	123	123	CD
cord-002407-25cawzi0	187	43	]	]	-RRB-
cord-002407-25cawzi0	187	44	[	[	-LRB-
cord-002407-25cawzi0	187	45	124	124	CD
cord-002407-25cawzi0	187	46	]	]	-RRB-
cord-002407-25cawzi0	187	47	.	.	.
cord-002407-25cawzi0	188	1	Moreover	moreover	RB
cord-002407-25cawzi0	188	2	,	,	,
cord-002407-25cawzi0	188	3	the	the	DT
cord-002407-25cawzi0	188	4	risk	risk	NN
cord-002407-25cawzi0	188	5	of	of	IN
cord-002407-25cawzi0	188	6	egg	egg	NN
cord-002407-25cawzi0	188	7	contamination	contamination	NN
cord-002407-25cawzi0	188	8	by	by	IN
cord-002407-25cawzi0	188	9	avian	avian	JJ
cord-002407-25cawzi0	188	10	pathogens	pathogen	NNS
cord-002407-25cawzi0	188	11	or	or	CC
cord-002407-25cawzi0	188	12	microbes	microbe	NNS
cord-002407-25cawzi0	188	13	represents	represent	VBZ
cord-002407-25cawzi0	188	14	a	a	DT
cord-002407-25cawzi0	188	15	risk	risk	NN
cord-002407-25cawzi0	188	16	for	for	IN
cord-002407-25cawzi0	188	17	the	the	DT
cord-002407-25cawzi0	188	18	production	production	NN
cord-002407-25cawzi0	188	19	of	of	IN
cord-002407-25cawzi0	188	20	influenza	influenza	NN
cord-002407-25cawzi0	188	21	vaccines	vaccine	NNS
cord-002407-25cawzi0	188	22	[	[	-LRB-
cord-002407-25cawzi0	188	23	125	125	CD
cord-002407-25cawzi0	188	24	,	,	,
cord-002407-25cawzi0	188	25	126	126	CD
cord-002407-25cawzi0	188	26	]	]	-RRB-
cord-002407-25cawzi0	188	27	.	.	.
cord-002407-25cawzi0	189	1	Importantly	importantly	RB
cord-002407-25cawzi0	189	2	,	,	,
cord-002407-25cawzi0	189	3	in	in	IN
cord-002407-25cawzi0	189	4	the	the	DT
cord-002407-25cawzi0	189	5	case	case	NN
cord-002407-25cawzi0	189	6	of	of	IN
cord-002407-25cawzi0	189	7	an	an	DT
cord-002407-25cawzi0	189	8	IAV	IAV	NNP
cord-002407-25cawzi0	189	9	pandemic	pandemic	NN
cord-002407-25cawzi0	189	10	,	,	,
cord-002407-25cawzi0	189	11	the	the	DT
cord-002407-25cawzi0	189	12	egg	egg	NN
cord-002407-25cawzi0	189	13	supplies	supply	NNS
cord-002407-25cawzi0	189	14	can	can	MD
cord-002407-25cawzi0	189	15	be	be	VB
cord-002407-25cawzi0	189	16	compromised	compromise	VBN
cord-002407-25cawzi0	189	17	.	.	.
cord-002407-25cawzi0	190	1	For	for	IN
cord-002407-25cawzi0	190	2	IIV	IIV	NNP
cord-002407-25cawzi0	190	3	,	,	,
cord-002407-25cawzi0	190	4	one	one	CD
cord-002407-25cawzi0	190	5	dose	dose	NN
cord-002407-25cawzi0	190	6	for	for	IN
cord-002407-25cawzi0	190	7	adults	adult	NNS
cord-002407-25cawzi0	190	8	contains	contain	VBZ
cord-002407-25cawzi0	190	9	approximately	approximately	RB
cord-002407-25cawzi0	190	10	45	45	CD
cord-002407-25cawzi0	190	11	µg	µg	NN
cord-002407-25cawzi0	190	12	of	of	IN
cord-002407-25cawzi0	190	13	HA	HA	NNP
cord-002407-25cawzi0	190	14	(	(	-LRB-
cord-002407-25cawzi0	190	15	15	15	CD
cord-002407-25cawzi0	190	16	µg	µg	NN
cord-002407-25cawzi0	190	17	of	of	IN
cord-002407-25cawzi0	190	18	viral	viral	JJ
cord-002407-25cawzi0	190	19	HA	HA	NNP
cord-002407-25cawzi0	190	20	for	for	IN
cord-002407-25cawzi0	190	21	each	each	DT
cord-002407-25cawzi0	190	22	of	of	IN
cord-002407-25cawzi0	190	23	the	the	DT
cord-002407-25cawzi0	190	24	three	three	CD
cord-002407-25cawzi0	190	25	antigenic	antigenic	JJ
cord-002407-25cawzi0	190	26	H1N1	H1N1	NNP
cord-002407-25cawzi0	190	27	,	,	,
cord-002407-25cawzi0	190	28	H3N2	H3N2	NNP
cord-002407-25cawzi0	190	29	and	and	CC
cord-002407-25cawzi0	190	30	IBV	IBV	NNP
cord-002407-25cawzi0	190	31	components	component	NNS
cord-002407-25cawzi0	190	32	)	)	-RRB-
cord-002407-25cawzi0	190	33	,	,	,
cord-002407-25cawzi0	190	34	meaning	mean	VBG
cord-002407-25cawzi0	190	35	one	one	CD
cord-002407-25cawzi0	190	36	egg	egg	NN
cord-002407-25cawzi0	190	37	=	=	SYM
cord-002407-25cawzi0	190	38	7	7	CD
cord-002407-25cawzi0	190	39	-	-	SYM
cord-002407-25cawzi0	190	40	10	10	CD
cord-002407-25cawzi0	190	41	dose	dose	NN
cord-002407-25cawzi0	190	42	of	of	IN
cord-002407-25cawzi0	190	43	vaccine	vaccine	NN
cord-002407-25cawzi0	190	44	.	.	.
cord-002407-25cawzi0	191	1	LAIVs	laiv	NNS
cord-002407-25cawzi0	191	2	share	share	VBP
cord-002407-25cawzi0	191	3	similar	similar	JJ
cord-002407-25cawzi0	191	4	egg	egg	NN
cord-002407-25cawzi0	191	5	-	-	HYPH
cord-002407-25cawzi0	191	6	based	base	VBN
cord-002407-25cawzi0	191	7	production	production	NN
cord-002407-25cawzi0	191	8	process	process	NN
cord-002407-25cawzi0	191	9	steps	step	NNS
cord-002407-25cawzi0	191	10	.	.	.
cord-002407-25cawzi0	192	1	The	the	DT
cord-002407-25cawzi0	192	2	LAIV	LAIV	NNP
cord-002407-25cawzi0	192	3	is	be	VBZ
cord-002407-25cawzi0	192	4	recovered	recover	VBN
cord-002407-25cawzi0	192	5	from	from	IN
cord-002407-25cawzi0	192	6	infected	infected	JJ
cord-002407-25cawzi0	192	7	eggs	egg	NNS
cord-002407-25cawzi0	192	8	and	and	CC
cord-002407-25cawzi0	192	9	then	then	RB
cord-002407-25cawzi0	192	10	purified	purify	VBN
cord-002407-25cawzi0	192	11	and	and	CC
cord-002407-25cawzi0	192	12	concentrated	concentrate	VBD
cord-002407-25cawzi0	192	13	[	[	-LRB-
cord-002407-25cawzi0	192	14	90	90	CD
cord-002407-25cawzi0	192	15	]	]	-RRB-
cord-002407-25cawzi0	192	16	.	.	.
cord-002407-25cawzi0	193	1	Importantly	importantly	RB
cord-002407-25cawzi0	193	2	,	,	,
cord-002407-25cawzi0	193	3	new	new	JJ
cord-002407-25cawzi0	193	4	vaccine	vaccine	NN
cord-002407-25cawzi0	193	5	production	production	NN
cord-002407-25cawzi0	193	6	approaches	approach	NNS
cord-002407-25cawzi0	193	7	that	that	WDT
cord-002407-25cawzi0	193	8	do	do	VBP
cord-002407-25cawzi0	193	9	not	not	RB
cord-002407-25cawzi0	193	10	depend	depend	VB
cord-002407-25cawzi0	193	11	on	on	IN
cord-002407-25cawzi0	193	12	the	the	DT
cord-002407-25cawzi0	193	13	propagation	propagation	NN
cord-002407-25cawzi0	193	14	of	of	IN
cord-002407-25cawzi0	193	15	influenza	influenza	NN
cord-002407-25cawzi0	193	16	viruses	virus	NNS
cord-002407-25cawzi0	193	17	in	in	IN
cord-002407-25cawzi0	193	18	eggs	egg	NNS
cord-002407-25cawzi0	193	19	(	(	-LRB-
cord-002407-25cawzi0	193	20	e.g.	e.g.	RB
cord-002407-25cawzi0	193	21	,	,	,
cord-002407-25cawzi0	193	22	cell	cell	NN
cord-002407-25cawzi0	193	23	cultures	culture	NNS
cord-002407-25cawzi0	193	24	)	)	-RRB-
cord-002407-25cawzi0	193	25	represent	represent	VBP
cord-002407-25cawzi0	193	26	an	an	DT
cord-002407-25cawzi0	193	27	excellent	excellent	JJ
cord-002407-25cawzi0	193	28	option	option	NN
cord-002407-25cawzi0	193	29	to	to	TO
cord-002407-25cawzi0	193	30	increase	increase	VB
cord-002407-25cawzi0	193	31	influenza	influenza	NN
cord-002407-25cawzi0	193	32	vaccine	vaccine	NN
cord-002407-25cawzi0	193	33	production	production	NN
cord-002407-25cawzi0	193	34	.	.	.
cord-002407-25cawzi0	194	1	Mammalian	mammalian	JJ
cord-002407-25cawzi0	194	2	cell	cell	NN
cord-002407-25cawzi0	194	3	cultures	culture	NNS
cord-002407-25cawzi0	194	4	have	have	VBP
cord-002407-25cawzi0	194	5	been	be	VBN
cord-002407-25cawzi0	194	6	used	use	VBN
cord-002407-25cawzi0	194	7	in	in	IN
cord-002407-25cawzi0	194	8	the	the	DT
cord-002407-25cawzi0	194	9	biopharmaceutical	biopharmaceutical	JJ
cord-002407-25cawzi0	194	10	industry	industry	NN
cord-002407-25cawzi0	194	11	for	for	IN
cord-002407-25cawzi0	194	12	the	the	DT
cord-002407-25cawzi0	194	13	production	production	NN
cord-002407-25cawzi0	194	14	of	of	IN
cord-002407-25cawzi0	194	15	therapeutic	therapeutic	JJ
cord-002407-25cawzi0	194	16	proteins	protein	NNS
cord-002407-25cawzi0	194	17	and/or	and/or	CC
cord-002407-25cawzi0	194	18	vaccines	vaccine	NNS
cord-002407-25cawzi0	194	19	[	[	-LRB-
cord-002407-25cawzi0	194	20	127	127	CD
cord-002407-25cawzi0	194	21	,	,	,
cord-002407-25cawzi0	194	22	128	128	CD
cord-002407-25cawzi0	194	23	]	]	-RRB-
cord-002407-25cawzi0	194	24	.	.	.
cord-002407-25cawzi0	195	1	In	in	IN
cord-002407-25cawzi0	195	2	2012	2012	CD
cord-002407-25cawzi0	195	3	,	,	,
cord-002407-25cawzi0	195	4	the	the	DT
cord-002407-25cawzi0	195	5	FDA	FDA	NNP
cord-002407-25cawzi0	195	6	approved	approve	VBD
cord-002407-25cawzi0	195	7	a	a	DT
cord-002407-25cawzi0	195	8	cell	cell	NN
cord-002407-25cawzi0	195	9	-	-	HYPH
cord-002407-25cawzi0	195	10	based	base	VBN
cord-002407-25cawzi0	195	11	production	production	NN
cord-002407-25cawzi0	195	12	process	process	NN
cord-002407-25cawzi0	195	13	for	for	IN
cord-002407-25cawzi0	195	14	influenza	influenza	NN
cord-002407-25cawzi0	195	15	vaccines	vaccine	NNS
cord-002407-25cawzi0	195	16	,	,	,
cord-002407-25cawzi0	195	17	but	but	CC
cord-002407-25cawzi0	195	18	the	the	DT
cord-002407-25cawzi0	195	19	manufacturing	manufacturing	NN
cord-002407-25cawzi0	195	20	process	process	NN
cord-002407-25cawzi0	195	21	begins	begin	VBZ
cord-002407-25cawzi0	195	22	with	with	IN
cord-002407-25cawzi0	195	23	egg	egg	NN
cord-002407-25cawzi0	195	24	-	-	HYPH
cord-002407-25cawzi0	195	25	grown	grow	VBN
cord-002407-25cawzi0	195	26	vaccine	vaccine	NN
cord-002407-25cawzi0	195	27	viruses	virus	NNS
cord-002407-25cawzi0	195	28	per	per	IN
cord-002407-25cawzi0	195	29	FDA	FDA	NNP
cord-002407-25cawzi0	195	30	regulations	regulation	NNS
cord-002407-25cawzi0	195	31	.	.	.
cord-002407-25cawzi0	196	1	Influenza	influenza	NN
cord-002407-25cawzi0	196	2	vaccine	vaccine	NN
cord-002407-25cawzi0	196	3	production	production	NN
cord-002407-25cawzi0	196	4	using	use	VBG
cord-002407-25cawzi0	196	5	FDA	FDA	NNP
cord-002407-25cawzi0	196	6	-	-	HYPH
cord-002407-25cawzi0	196	7	approved	approve	VBN
cord-002407-25cawzi0	196	8	MDCK	MDCK	NNP
cord-002407-25cawzi0	196	9	or	or	CC
cord-002407-25cawzi0	196	10	Vero	Vero	NNP
cord-002407-25cawzi0	197	1	(	(	-LRB-
cord-002407-25cawzi0	197	2	African	african	JJ
cord-002407-25cawzi0	197	3	green	green	JJ
cord-002407-25cawzi0	197	4	monkey	monkey	NN
cord-002407-25cawzi0	197	5	kidney	kidney	NN
cord-002407-25cawzi0	197	6	)	)	-RRB-
cord-002407-25cawzi0	197	7	cells	cell	NNS
cord-002407-25cawzi0	197	8	may	may	MD
cord-002407-25cawzi0	197	9	eventually	eventually	RB
cord-002407-25cawzi0	197	10	and	and	CC
cord-002407-25cawzi0	197	11	completely	completely	RB
cord-002407-25cawzi0	197	12	replace	replace	VB
cord-002407-25cawzi0	197	13	the	the	DT
cord-002407-25cawzi0	197	14	use	use	NN
cord-002407-25cawzi0	197	15	of	of	IN
cord-002407-25cawzi0	197	16	eggs	egg	NNS
cord-002407-25cawzi0	197	17	for	for	IN
cord-002407-25cawzi0	197	18	the	the	DT
cord-002407-25cawzi0	197	19	production	production	NN
cord-002407-25cawzi0	197	20	of	of	IN
cord-002407-25cawzi0	197	21	influenza	influenza	NN
cord-002407-25cawzi0	197	22	vaccines	vaccine	NNS
cord-002407-25cawzi0	197	23	in	in	IN
cord-002407-25cawzi0	197	24	the	the	DT
cord-002407-25cawzi0	197	25	future	future	NN
cord-002407-25cawzi0	197	26	.	.	.
cord-002407-25cawzi0	198	1	Influenza	influenza	NN
cord-002407-25cawzi0	198	2	vaccine	vaccine	NN
cord-002407-25cawzi0	198	3	production	production	NN
cord-002407-25cawzi0	198	4	in	in	IN
cord-002407-25cawzi0	198	5	mammalian	mammalian	JJ
cord-002407-25cawzi0	198	6	cell	cell	NN
cord-002407-25cawzi0	198	7	lines	line	NNS
cord-002407-25cawzi0	198	8	offers	offer	VBZ
cord-002407-25cawzi0	198	9	several	several	JJ
cord-002407-25cawzi0	198	10	advantages	advantage	NNS
cord-002407-25cawzi0	198	11	over	over	IN
cord-002407-25cawzi0	198	12	egg	egg	NN
cord-002407-25cawzi0	198	13	-	-	HYPH
cord-002407-25cawzi0	198	14	based	base	VBN
cord-002407-25cawzi0	198	15	production	production	NN
cord-002407-25cawzi0	198	16	:	:	:
cord-002407-25cawzi0	198	17	it	-PRON-	PRP
cord-002407-25cawzi0	198	18	allows	allow	VBZ
cord-002407-25cawzi0	198	19	faster	fast	RBR
cord-002407-25cawzi0	198	20	and	and	CC
cord-002407-25cawzi0	198	21	greater	great	JJR
cord-002407-25cawzi0	198	22	production	production	NN
cord-002407-25cawzi0	198	23	capacity	capacity	NN
cord-002407-25cawzi0	198	24	,	,	,
cord-002407-25cawzi0	198	25	improved	improve	VBN
cord-002407-25cawzi0	198	26	availability	availability	NN
cord-002407-25cawzi0	198	27	of	of	IN
cord-002407-25cawzi0	198	28	substrate	substrate	NN
cord-002407-25cawzi0	198	29	for	for	IN
cord-002407-25cawzi0	198	30	virus	virus	NN
cord-002407-25cawzi0	198	31	growth	growth	NN
cord-002407-25cawzi0	198	32	[	[	-LRB-
cord-002407-25cawzi0	198	33	122	122	CD
cord-002407-25cawzi0	198	34	,	,	,
cord-002407-25cawzi0	198	35	127	127	CD
cord-002407-25cawzi0	198	36	]	]	-RRB-
cord-002407-25cawzi0	198	37	and	and	CC
cord-002407-25cawzi0	198	38	eliminates	eliminate	VBZ
cord-002407-25cawzi0	198	39	reliance	reliance	NN
cord-002407-25cawzi0	198	40	on	on	IN
cord-002407-25cawzi0	198	41	the	the	DT
cord-002407-25cawzi0	198	42	supply	supply	NN
cord-002407-25cawzi0	198	43	of	of	IN
cord-002407-25cawzi0	198	44	embryonated	embryonate	VBN
cord-002407-25cawzi0	198	45	chicken	chicken	NN
cord-002407-25cawzi0	198	46	eggs	egg	NNS
cord-002407-25cawzi0	198	47	[	[	-LRB-
cord-002407-25cawzi0	198	48	129	129	CD
cord-002407-25cawzi0	198	49	,	,	,
cord-002407-25cawzi0	198	50	130	130	CD
cord-002407-25cawzi0	198	51	]	]	-RRB-
cord-002407-25cawzi0	198	52	.	.	.
cord-002407-25cawzi0	199	1	In	in	IN
cord-002407-25cawzi0	199	2	addition	addition	NN
cord-002407-25cawzi0	199	3	,	,	,
cord-002407-25cawzi0	199	4	cell	cell	NN
cord-002407-25cawzi0	199	5	cultures	culture	NNS
cord-002407-25cawzi0	199	6	can	can	MD
cord-002407-25cawzi0	199	7	be	be	VB
cord-002407-25cawzi0	199	8	cryopreserved	cryopreserve	VBN
cord-002407-25cawzi0	199	9	and	and	CC
cord-002407-25cawzi0	199	10	scaled	scale	VBN
cord-002407-25cawzi0	199	11	up	up	RP
cord-002407-25cawzi0	199	12	in	in	IN
cord-002407-25cawzi0	199	13	bioreactors	bioreactor	NNS
cord-002407-25cawzi0	199	14	at	at	IN
cord-002407-25cawzi0	199	15	any	any	DT
cord-002407-25cawzi0	199	16	time	time	NN
cord-002407-25cawzi0	199	17	.	.	.
cord-002407-25cawzi0	200	1	Adjuvants	adjuvant	NNS
cord-002407-25cawzi0	200	2	have	have	VBP
cord-002407-25cawzi0	200	3	been	be	VBN
cord-002407-25cawzi0	200	4	shown	show	VBN
cord-002407-25cawzi0	200	5	to	to	TO
cord-002407-25cawzi0	200	6	enhance	enhance	VB
cord-002407-25cawzi0	200	7	the	the	DT
cord-002407-25cawzi0	200	8	immune	immune	JJ
cord-002407-25cawzi0	200	9	response	response	NN
cord-002407-25cawzi0	200	10	elicited	elicit	VBN
cord-002407-25cawzi0	200	11	by	by	IN
cord-002407-25cawzi0	200	12	an	an	DT
cord-002407-25cawzi0	200	13	antigen	antigen	NN
cord-002407-25cawzi0	200	14	and	and	CC
cord-002407-25cawzi0	200	15	could	could	MD
cord-002407-25cawzi0	200	16	be	be	VB
cord-002407-25cawzi0	200	17	used	use	VBN
cord-002407-25cawzi0	200	18	to	to	TO
cord-002407-25cawzi0	200	19	improve	improve	VB
cord-002407-25cawzi0	200	20	the	the	DT
cord-002407-25cawzi0	200	21	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	200	22	of	of	IN
cord-002407-25cawzi0	200	23	IIV	IIV	NNP
cord-002407-25cawzi0	200	24	[	[	-LRB-
cord-002407-25cawzi0	200	25	131	131	CD
cord-002407-25cawzi0	200	26	,	,	,
cord-002407-25cawzi0	200	27	132	132	CD
cord-002407-25cawzi0	200	28	]	]	-RRB-
cord-002407-25cawzi0	200	29	.	.	.
cord-002407-25cawzi0	201	1	The	the	DT
cord-002407-25cawzi0	201	2	use	use	NN
cord-002407-25cawzi0	201	3	of	of	IN
cord-002407-25cawzi0	201	4	adjuvants	adjuvant	NNS
cord-002407-25cawzi0	201	5	could	could	MD
cord-002407-25cawzi0	201	6	also	also	RB
cord-002407-25cawzi0	201	7	reduce	reduce	VB
cord-002407-25cawzi0	201	8	vaccine	vaccine	NN
cord-002407-25cawzi0	201	9	dose	dose	NN
cord-002407-25cawzi0	201	10	,	,	,
cord-002407-25cawzi0	201	11	stretching	stretch	VBG
cord-002407-25cawzi0	201	12	antigen	antigen	NN
cord-002407-25cawzi0	201	13	and	and	CC
cord-002407-25cawzi0	201	14	vaccine	vaccine	NN
cord-002407-25cawzi0	201	15	supplies	supply	NNS
cord-002407-25cawzi0	201	16	.	.	.
cord-002407-25cawzi0	202	1	Currently	currently	RB
cord-002407-25cawzi0	202	2	,	,	,
cord-002407-25cawzi0	202	3	FDA	FDA	NNP
cord-002407-25cawzi0	202	4	-	-	HYPH
cord-002407-25cawzi0	202	5	licensed	license	VBN
cord-002407-25cawzi0	202	6	adjuvants	adjuvant	NNS
cord-002407-25cawzi0	202	7	for	for	IN
cord-002407-25cawzi0	202	8	influenza	influenza	JJ
cord-002407-25cawzi0	202	9	vaccine	vaccine	NN
cord-002407-25cawzi0	202	10	usage	usage	NN
cord-002407-25cawzi0	202	11	include	include	VBP
cord-002407-25cawzi0	202	12	aluminum	aluminum	NN
cord-002407-25cawzi0	202	13	salt	salt	NN
cord-002407-25cawzi0	202	14	(	(	-LRB-
cord-002407-25cawzi0	202	15	alum	alum	NN
cord-002407-25cawzi0	202	16	)	)	-RRB-
cord-002407-25cawzi0	202	17	and	and	CC
cord-002407-25cawzi0	202	18	the	the	DT
cord-002407-25cawzi0	202	19	squalene	squalene	NN
cord-002407-25cawzi0	202	20	oil	oil	NN
cord-002407-25cawzi0	202	21	-	-	HYPH
cord-002407-25cawzi0	202	22	in	in	IN
cord-002407-25cawzi0	202	23	-	-	HYPH
cord-002407-25cawzi0	202	24	water	water	NN
cord-002407-25cawzi0	202	25	emulsion	emulsion	NN
cord-002407-25cawzi0	202	26	systems	system	NNS
cord-002407-25cawzi0	202	27	MF59	MF59	NNP
cord-002407-25cawzi0	203	1	(	(	-LRB-
cord-002407-25cawzi0	203	2	Wadman	Wadman	NNP
cord-002407-25cawzi0	203	3	2005	2005	CD
cord-002407-25cawzi0	203	4	(	(	-LRB-
cord-002407-25cawzi0	203	5	Novartis	Novartis	NNP
cord-002407-25cawzi0	203	6	)	)	-RRB-
cord-002407-25cawzi0	203	7	)	)	-RRB-
cord-002407-25cawzi0	204	1	[	[	-LRB-
cord-002407-25cawzi0	204	2	133	133	CD
cord-002407-25cawzi0	204	3	]	]	-RRB-
cord-002407-25cawzi0	204	4	and	and	CC
cord-002407-25cawzi0	204	5	AS03	AS03	NNP
cord-002407-25cawzi0	204	6	(	(	-LRB-
cord-002407-25cawzi0	204	7	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-002407-25cawzi0	204	8	)	)	-RRB-
cord-002407-25cawzi0	204	9	[	[	-LRB-
cord-002407-25cawzi0	204	10	134	134	CD
cord-002407-25cawzi0	204	11	]	]	-RRB-
cord-002407-25cawzi0	204	12	.	.	.
cord-002407-25cawzi0	205	1	However	however	RB
cord-002407-25cawzi0	205	2	,	,	,
cord-002407-25cawzi0	205	3	most	most	JJS
cord-002407-25cawzi0	205	4	of	of	IN
cord-002407-25cawzi0	205	5	the	the	DT
cord-002407-25cawzi0	205	6	current	current	JJ
cord-002407-25cawzi0	205	7	IIVs	iiv	NNS
cord-002407-25cawzi0	205	8	do	do	VBP
cord-002407-25cawzi0	205	9	not	not	RB
cord-002407-25cawzi0	205	10	contain	contain	VB
cord-002407-25cawzi0	205	11	any	any	DT
cord-002407-25cawzi0	205	12	type	type	NN
cord-002407-25cawzi0	205	13	of	of	IN
cord-002407-25cawzi0	205	14	adjuvant	adjuvant	NN
cord-002407-25cawzi0	205	15	,	,	,
cord-002407-25cawzi0	205	16	but	but	CC
cord-002407-25cawzi0	205	17	many	many	JJ
cord-002407-25cawzi0	205	18	are	be	VBP
cord-002407-25cawzi0	205	19	under	under	IN
cord-002407-25cawzi0	205	20	investigation	investigation	NN
cord-002407-25cawzi0	205	21	.	.	.
cord-002407-25cawzi0	206	1	Genetics	genetics	NN
cord-002407-25cawzi0	206	2	techniques	technique	NNS
cord-002407-25cawzi0	206	3	to	to	TO
cord-002407-25cawzi0	206	4	generate	generate	VB
cord-002407-25cawzi0	206	5	recombinant	recombinant	JJ
cord-002407-25cawzi0	206	6	viruses	virus	NNS
cord-002407-25cawzi0	206	7	were	be	VBD
cord-002407-25cawzi0	206	8	first	first	RB
cord-002407-25cawzi0	206	9	developed	develop	VBN
cord-002407-25cawzi0	206	10	for	for	IN
cord-002407-25cawzi0	206	11	DNA	dna	NN
cord-002407-25cawzi0	206	12	viruses	virus	NNS
cord-002407-25cawzi0	206	13	and	and	CC
cord-002407-25cawzi0	206	14	based	base	VBN
cord-002407-25cawzi0	206	15	on	on	IN
cord-002407-25cawzi0	206	16	the	the	DT
cord-002407-25cawzi0	206	17	transfection	transfection	NN
cord-002407-25cawzi0	206	18	of	of	IN
cord-002407-25cawzi0	206	19	cells	cell	NNS
cord-002407-25cawzi0	206	20	with	with	IN
cord-002407-25cawzi0	206	21	plasmids	plasmid	NNS
cord-002407-25cawzi0	206	22	encoding	encode	VBG
cord-002407-25cawzi0	206	23	the	the	DT
cord-002407-25cawzi0	206	24	viral	viral	JJ
cord-002407-25cawzi0	206	25	genome	genome	NN
cord-002407-25cawzi0	206	26	or	or	CC
cord-002407-25cawzi0	206	27	by	by	IN
cord-002407-25cawzi0	206	28	heterologous	heterologous	JJ
cord-002407-25cawzi0	206	29	recombination	recombination	NN
cord-002407-25cawzi0	206	30	between	between	IN
cord-002407-25cawzi0	206	31	plasmids	plasmid	NNS
cord-002407-25cawzi0	206	32	bearing	bear	VBG
cord-002407-25cawzi0	206	33	viral	viral	JJ
cord-002407-25cawzi0	206	34	sequences	sequence	NNS
cord-002407-25cawzi0	206	35	with	with	IN
cord-002407-25cawzi0	206	36	the	the	DT
cord-002407-25cawzi0	206	37	virus	virus	NN
cord-002407-25cawzi0	206	38	genome	genome	NN
cord-002407-25cawzi0	206	39	and	and	CC
cord-002407-25cawzi0	206	40	the	the	DT
cord-002407-25cawzi0	206	41	helper	helper	NN
cord-002407-25cawzi0	206	42	virus	virus	NN
cord-002407-25cawzi0	206	43	[	[	-LRB-
cord-002407-25cawzi0	206	44	135	135	CD
cord-002407-25cawzi0	206	45	]	]	-RRB-
cord-002407-25cawzi0	206	46	.	.	.
cord-002407-25cawzi0	207	1	Initial	initial	JJ
cord-002407-25cawzi0	207	2	genetics	genetics	NN
cord-002407-25cawzi0	207	3	approaches	approach	VBZ
cord-002407-25cawzi0	207	4	for	for	IN
cord-002407-25cawzi0	207	5	DNA	dna	NN
cord-002407-25cawzi0	207	6	viruses	virus	NNS
cord-002407-25cawzi0	207	7	were	be	VBD
cord-002407-25cawzi0	207	8	followed	follow	VBN
cord-002407-25cawzi0	207	9	by	by	IN
cord-002407-25cawzi0	207	10	manipulations	manipulation	NNS
cord-002407-25cawzi0	207	11	of	of	IN
cord-002407-25cawzi0	207	12	positive	positive	JJ
cord-002407-25cawzi0	207	13	-	-	HYPH
cord-002407-25cawzi0	207	14	sense	sense	NN
cord-002407-25cawzi0	207	15	RNA	RNA	NNP
cord-002407-25cawzi0	207	16	viral	viral	JJ
cord-002407-25cawzi0	207	17	genomes	genome	NNS
cord-002407-25cawzi0	207	18	[	[	-LRB-
cord-002407-25cawzi0	207	19	136	136	CD
cord-002407-25cawzi0	207	20	,	,	,
cord-002407-25cawzi0	207	21	137	137	CD
cord-002407-25cawzi0	207	22	]	]	-RRB-
cord-002407-25cawzi0	207	23	.	.	.
cord-002407-25cawzi0	208	1	Transfection	transfection	NN
cord-002407-25cawzi0	208	2	of	of	IN
cord-002407-25cawzi0	208	3	plasmid	plasmid	NN
cord-002407-25cawzi0	208	4	DNA	dna	NN
cord-002407-25cawzi0	208	5	,	,	,
cord-002407-25cawzi0	208	6	or	or	CC
cord-002407-25cawzi0	208	7	RNA	RNA	NNP
cord-002407-25cawzi0	208	8	transcribed	transcribe	VBN
cord-002407-25cawzi0	208	9	directly	directly	RB
cord-002407-25cawzi0	208	10	in	in	IN
cord-002407-25cawzi0	208	11	vitro	vitro	FW
cord-002407-25cawzi0	208	12	from	from	IN
cord-002407-25cawzi0	208	13	plasmids	plasmid	NNS
cord-002407-25cawzi0	208	14	,	,	,
cord-002407-25cawzi0	208	15	containing	contain	VBG
cord-002407-25cawzi0	208	16	the	the	DT
cord-002407-25cawzi0	208	17	genome	genome	NN
cord-002407-25cawzi0	208	18	of	of	IN
cord-002407-25cawzi0	208	19	poliovirus	poliovirus	NN
cord-002407-25cawzi0	208	20	into	into	IN
cord-002407-25cawzi0	208	21	susceptible	susceptible	JJ
cord-002407-25cawzi0	208	22	cells	cell	NNS
cord-002407-25cawzi0	208	23	led	lead	VBD
cord-002407-25cawzi0	208	24	to	to	IN
cord-002407-25cawzi0	208	25	the	the	DT
cord-002407-25cawzi0	208	26	generation	generation	NN
cord-002407-25cawzi0	208	27	of	of	IN
cord-002407-25cawzi0	208	28	recombinant	recombinant	JJ
cord-002407-25cawzi0	208	29	infectious	infectious	JJ
cord-002407-25cawzi0	208	30	poliovirus	poliovirus	NN
cord-002407-25cawzi0	208	31	[	[	-LRB-
cord-002407-25cawzi0	208	32	138	138	CD
cord-002407-25cawzi0	208	33	]	]	-RRB-
cord-002407-25cawzi0	208	34	.	.	.
cord-002407-25cawzi0	209	1	However	however	RB
cord-002407-25cawzi0	209	2	,	,	,
cord-002407-25cawzi0	209	3	the	the	DT
cord-002407-25cawzi0	209	4	genomes	genome	NNS
cord-002407-25cawzi0	209	5	of	of	IN
cord-002407-25cawzi0	209	6	negative	negative	JJ
cord-002407-25cawzi0	209	7	-	-	HYPH
cord-002407-25cawzi0	209	8	sense	sense	NN
cord-002407-25cawzi0	209	9	RNA	RNA	NNP
cord-002407-25cawzi0	209	10	viruses	virus	NNS
cord-002407-25cawzi0	209	11	,	,	,
cord-002407-25cawzi0	209	12	including	include	VBG
cord-002407-25cawzi0	209	13	influenza	influenza	NN
cord-002407-25cawzi0	209	14	,	,	,
cord-002407-25cawzi0	209	15	were	be	VBD
cord-002407-25cawzi0	209	16	less	less	RBR
cord-002407-25cawzi0	209	17	suitable	suitable	JJ
cord-002407-25cawzi0	209	18	to	to	IN
cord-002407-25cawzi0	209	19	molecular	molecular	JJ
cord-002407-25cawzi0	209	20	biology	biology	NN
cord-002407-25cawzi0	209	21	manipulations	manipulation	NNS
cord-002407-25cawzi0	209	22	in	in	IN
cord-002407-25cawzi0	209	23	comparison	comparison	NN
cord-002407-25cawzi0	209	24	with	with	IN
cord-002407-25cawzi0	209	25	DNA	dna	NN
cord-002407-25cawzi0	209	26	or	or	CC
cord-002407-25cawzi0	209	27	positive	positive	JJ
cord-002407-25cawzi0	209	28	-	-	HYPH
cord-002407-25cawzi0	209	29	sense	sense	NN
cord-002407-25cawzi0	209	30	RNA	RNA	NNP
cord-002407-25cawzi0	209	31	viruses	virus	NNS
cord-002407-25cawzi0	209	32	since	since	IN
cord-002407-25cawzi0	209	33	their	-PRON-	PRP$
cord-002407-25cawzi0	209	34	genomes	genome	NNS
cord-002407-25cawzi0	209	35	are	be	VBP
cord-002407-25cawzi0	209	36	complementary	complementary	JJ
cord-002407-25cawzi0	209	37	to	to	IN
cord-002407-25cawzi0	209	38	mRNA	mrna	NN
cord-002407-25cawzi0	209	39	in	in	IN
cord-002407-25cawzi0	209	40	their	-PRON-	PRP$
cord-002407-25cawzi0	209	41	orientation	orientation	NN
cord-002407-25cawzi0	209	42	and	and	CC
cord-002407-25cawzi0	209	43	,	,	,
cord-002407-25cawzi0	209	44	therefore	therefore	RB
cord-002407-25cawzi0	209	45	,	,	,
cord-002407-25cawzi0	209	46	not	not	RB
cord-002407-25cawzi0	209	47	infectious	infectious	JJ
cord-002407-25cawzi0	209	48	by	by	IN
cord-002407-25cawzi0	209	49	themselves	-PRON-	PRP
cord-002407-25cawzi0	209	50	[	[	-LRB-
cord-002407-25cawzi0	209	51	1	1	CD
cord-002407-25cawzi0	209	52	,	,	,
cord-002407-25cawzi0	209	53	7	7	CD
cord-002407-25cawzi0	209	54	]	]	-RRB-
cord-002407-25cawzi0	209	55	.	.	.
cord-002407-25cawzi0	210	1	They	-PRON-	PRP
cord-002407-25cawzi0	210	2	require	require	VBP
cord-002407-25cawzi0	210	3	the	the	DT
cord-002407-25cawzi0	210	4	presence	presence	NN
cord-002407-25cawzi0	210	5	of	of	IN
cord-002407-25cawzi0	210	6	vRNA(s	vrna(s	NN
cord-002407-25cawzi0	210	7	)	)	-RRB-
cord-002407-25cawzi0	210	8	and	and	CC
cord-002407-25cawzi0	210	9	the	the	DT
cord-002407-25cawzi0	210	10	viral	viral	JJ
cord-002407-25cawzi0	210	11	RdRps	RdRps	NNP
cord-002407-25cawzi0	210	12	to	to	TO
cord-002407-25cawzi0	210	13	initiate	initiate	VB
cord-002407-25cawzi0	210	14	the	the	DT
cord-002407-25cawzi0	210	15	replication	replication	NN
cord-002407-25cawzi0	210	16	cycle	cycle	NN
cord-002407-25cawzi0	210	17	of	of	IN
cord-002407-25cawzi0	210	18	the	the	DT
cord-002407-25cawzi0	210	19	virus	virus	NN
cord-002407-25cawzi0	210	20	[	[	-LRB-
cord-002407-25cawzi0	210	21	33	33	CD
cord-002407-25cawzi0	210	22	,	,	,
cord-002407-25cawzi0	210	23	44	44	CD
cord-002407-25cawzi0	210	24	]	]	-RRB-
cord-002407-25cawzi0	210	25	.	.	.
cord-002407-25cawzi0	211	1	The	the	DT
cord-002407-25cawzi0	211	2	advent	advent	NN
cord-002407-25cawzi0	211	3	of	of	IN
cord-002407-25cawzi0	211	4	reverse	reverse	JJ
cord-002407-25cawzi0	211	5	genetics	genetic	NNS
cord-002407-25cawzi0	211	6	and	and	CC
cord-002407-25cawzi0	211	7	molecular	molecular	JJ
cord-002407-25cawzi0	211	8	engineering	engineering	NN
cord-002407-25cawzi0	211	9	has	have	VBZ
cord-002407-25cawzi0	211	10	transformed	transform	VBN
cord-002407-25cawzi0	211	11	the	the	DT
cord-002407-25cawzi0	211	12	influenza	influenza	NN
cord-002407-25cawzi0	211	13	field	field	NN
cord-002407-25cawzi0	211	14	,	,	,
cord-002407-25cawzi0	211	15	allowing	allow	VBG
cord-002407-25cawzi0	211	16	multiple	multiple	JJ
cord-002407-25cawzi0	211	17	questions	question	NNS
cord-002407-25cawzi0	211	18	to	to	TO
cord-002407-25cawzi0	211	19	be	be	VB
cord-002407-25cawzi0	211	20	answered	answer	VBN
cord-002407-25cawzi0	211	21	using	use	VBG
cord-002407-25cawzi0	211	22	genetically	genetically	RB
cord-002407-25cawzi0	211	23	-	-	HYPH
cord-002407-25cawzi0	211	24	engineered	engineer	VBN
cord-002407-25cawzi0	211	25	recombinant	recombinant	JJ
cord-002407-25cawzi0	211	26	influenza	influenza	NN
cord-002407-25cawzi0	211	27	viruses	virus	NNS
cord-002407-25cawzi0	211	28	[	[	-LRB-
cord-002407-25cawzi0	211	29	139	139	CD
cord-002407-25cawzi0	211	30	]	]	-RRB-
cord-002407-25cawzi0	211	31	.	.	.
cord-002407-25cawzi0	212	1	Such	such	JJ
cord-002407-25cawzi0	212	2	studies	study	NNS
cord-002407-25cawzi0	212	3	include	include	VBP
cord-002407-25cawzi0	212	4	mechanisms	mechanism	NNS
cord-002407-25cawzi0	212	5	of	of	IN
cord-002407-25cawzi0	212	6	viral	viral	JJ
cord-002407-25cawzi0	212	7	genome	genome	NN
cord-002407-25cawzi0	212	8	replication	replication	NN
cord-002407-25cawzi0	212	9	and	and	CC
cord-002407-25cawzi0	212	10	gene	gene	NN
cord-002407-25cawzi0	212	11	transcription	transcription	NN
cord-002407-25cawzi0	212	12	,	,	,
cord-002407-25cawzi0	212	13	pathogenicity	pathogenicity	NN
cord-002407-25cawzi0	212	14	and	and	CC
cord-002407-25cawzi0	212	15	virulence	virulence	NN
cord-002407-25cawzi0	212	16	,	,	,
cord-002407-25cawzi0	212	17	virus	virus	NN
cord-002407-25cawzi0	212	18	-	-	HYPH
cord-002407-25cawzi0	212	19	host	host	NN
cord-002407-25cawzi0	212	20	interactions	interaction	NNS
cord-002407-25cawzi0	212	21	or	or	CC
cord-002407-25cawzi0	212	22	host	host	NN
cord-002407-25cawzi0	212	23	range	range	NN
cord-002407-25cawzi0	212	24	and	and	CC
cord-002407-25cawzi0	212	25	transmissibility	transmissibility	NN
cord-002407-25cawzi0	212	26	[	[	-LRB-
cord-002407-25cawzi0	212	27	12	12	CD
cord-002407-25cawzi0	212	28	,	,	,
cord-002407-25cawzi0	212	29	13	13	CD
cord-002407-25cawzi0	212	30	,	,	,
cord-002407-25cawzi0	212	31	139	139	CD
cord-002407-25cawzi0	212	32	,	,	,
cord-002407-25cawzi0	212	33	140	140	CD
cord-002407-25cawzi0	212	34	]	]	-RRB-
cord-002407-25cawzi0	212	35	.	.	.
cord-002407-25cawzi0	213	1	Moreover	moreover	RB
cord-002407-25cawzi0	213	2	,	,	,
cord-002407-25cawzi0	213	3	these	these	DT
cord-002407-25cawzi0	213	4	technologies	technology	NNS
cord-002407-25cawzi0	213	5	have	have	VBP
cord-002407-25cawzi0	213	6	been	be	VBN
cord-002407-25cawzi0	213	7	implemented	implement	VBN
cord-002407-25cawzi0	213	8	to	to	TO
cord-002407-25cawzi0	213	9	develop	develop	VB
cord-002407-25cawzi0	213	10	influenza	influenza	NN
cord-002407-25cawzi0	213	11	vaccines	vaccine	NNS
cord-002407-25cawzi0	213	12	[	[	-LRB-
cord-002407-25cawzi0	213	13	141	141	CD
cord-002407-25cawzi0	213	14	]	]	-RRB-
cord-002407-25cawzi0	213	15	and	and	CC
cord-002407-25cawzi0	213	16	to	to	TO
cord-002407-25cawzi0	213	17	generate	generate	VB
cord-002407-25cawzi0	213	18	recombinant	recombinant	JJ
cord-002407-25cawzi0	213	19	influenza	influenza	NN
cord-002407-25cawzi0	213	20	viruses	virus	NNS
cord-002407-25cawzi0	213	21	expressing	express	VBG
cord-002407-25cawzi0	213	22	foreign	foreign	JJ
cord-002407-25cawzi0	213	23	proteins	protein	NNS
cord-002407-25cawzi0	213	24	as	as	IN
cord-002407-25cawzi0	213	25	vaccine	vaccine	NN
cord-002407-25cawzi0	213	26	vectors	vector	NNS
cord-002407-25cawzi0	213	27	[	[	-LRB-
cord-002407-25cawzi0	213	28	142	142	CD
cord-002407-25cawzi0	213	29	]	]	-RRB-
cord-002407-25cawzi0	213	30	[	[	-LRB-
cord-002407-25cawzi0	213	31	143	143	CD
cord-002407-25cawzi0	213	32	]	]	-RRB-
cord-002407-25cawzi0	213	33	[	[	-LRB-
cord-002407-25cawzi0	213	34	144	144	CD
cord-002407-25cawzi0	213	35	]	]	-RRB-
cord-002407-25cawzi0	213	36	or	or	CC
cord-002407-25cawzi0	213	37	harboring	harbor	VBG
cord-002407-25cawzi0	213	38	reporter	reporter	NN
cord-002407-25cawzi0	213	39	genes	gene	NNS
cord-002407-25cawzi0	213	40	to	to	TO
cord-002407-25cawzi0	213	41	easily	easily	RB
cord-002407-25cawzi0	213	42	track	track	VB
cord-002407-25cawzi0	213	43	viral	viral	JJ
cord-002407-25cawzi0	213	44	infections	infection	NNS
cord-002407-25cawzi0	213	45	[	[	-LRB-
cord-002407-25cawzi0	213	46	142	142	CD
cord-002407-25cawzi0	213	47	,	,	,
cord-002407-25cawzi0	213	48	[	[	-LRB-
cord-002407-25cawzi0	213	49	145	145	CD
cord-002407-25cawzi0	213	50	]	]	-RRB-
cord-002407-25cawzi0	213	51	[	[	-LRB-
cord-002407-25cawzi0	213	52	146	146	CD
cord-002407-25cawzi0	213	53	]	]	-RRB-
cord-002407-25cawzi0	213	54	[	[	-LRB-
cord-002407-25cawzi0	213	55	147	147	CD
cord-002407-25cawzi0	213	56	]	]	-RRB-
cord-002407-25cawzi0	213	57	.	.	.
cord-002407-25cawzi0	214	1	Plasmid	plasmid	NN
cord-002407-25cawzi0	214	2	-	-	HYPH
cord-002407-25cawzi0	214	3	based	base	VBN
cord-002407-25cawzi0	214	4	reverse	reverse	JJ
cord-002407-25cawzi0	214	5	genetics	genetic	NNS
cord-002407-25cawzi0	214	6	for	for	IN
cord-002407-25cawzi0	214	7	influenza	influenza	NN
cord-002407-25cawzi0	214	8	virus	virus	NN
cord-002407-25cawzi0	214	9	allows	allow	VBZ
cord-002407-25cawzi0	214	10	for	for	IN
cord-002407-25cawzi0	214	11	the	the	DT
cord-002407-25cawzi0	214	12	simultaneous	simultaneous	JJ
cord-002407-25cawzi0	214	13	expression	expression	NN
cord-002407-25cawzi0	214	14	of	of	IN
cord-002407-25cawzi0	214	15	the	the	DT
cord-002407-25cawzi0	214	16	viral	viral	JJ
cord-002407-25cawzi0	214	17	components	component	NNS
cord-002407-25cawzi0	214	18	involved	involve	VBN
cord-002407-25cawzi0	214	19	in	in	IN
cord-002407-25cawzi0	214	20	viral	viral	JJ
cord-002407-25cawzi0	214	21	genome	genome	NN
cord-002407-25cawzi0	214	22	replication	replication	NN
cord-002407-25cawzi0	214	23	and	and	CC
cord-002407-25cawzi0	214	24	gene	gene	NN
cord-002407-25cawzi0	214	25	transcription	transcription	NN
cord-002407-25cawzi0	214	26	(	(	-LRB-
cord-002407-25cawzi0	214	27	PB2	PB2	NNP
cord-002407-25cawzi0	214	28	,	,	,
cord-002407-25cawzi0	214	29	PB1	PB1	NNP
cord-002407-25cawzi0	214	30	,	,	,
cord-002407-25cawzi0	214	31	PA	PA	NNP
cord-002407-25cawzi0	214	32	and	and	CC
cord-002407-25cawzi0	214	33	NP	NP	NNP
cord-002407-25cawzi0	214	34	)	)	-RRB-
cord-002407-25cawzi0	214	35	and	and	CC
cord-002407-25cawzi0	214	36	the	the	DT
cord-002407-25cawzi0	214	37	eight	eight	CD
cord-002407-25cawzi0	214	38	negative	negative	JJ
cord-002407-25cawzi0	214	39	-	-	HYPH
cord-002407-25cawzi0	214	40	stranded	stranded	JJ
cord-002407-25cawzi0	214	41	vRNAs	vrna	NNS
cord-002407-25cawzi0	214	42	in	in	IN
cord-002407-25cawzi0	214	43	transfected	transfecte	VBN
cord-002407-25cawzi0	214	44	susceptible	susceptible	JJ
cord-002407-25cawzi0	214	45	cells	cell	NNS
cord-002407-25cawzi0	214	46	,	,	,
cord-002407-25cawzi0	214	47	which	which	WDT
cord-002407-25cawzi0	214	48	together	together	RB
cord-002407-25cawzi0	214	49	generate	generate	VBP
cord-002407-25cawzi0	214	50	de	de	FW
cord-002407-25cawzi0	214	51	novo	novo	NNP
cord-002407-25cawzi0	214	52	,	,	,
cord-002407-25cawzi0	214	53	recombinant	recombinant	JJ
cord-002407-25cawzi0	214	54	IAVs	iav	NNS
cord-002407-25cawzi0	214	55	or	or	CC
cord-002407-25cawzi0	214	56	IBVs	ibv	NNS
cord-002407-25cawzi0	214	57	(	(	-LRB-
cord-002407-25cawzi0	214	58	Figure	figure	NN
cord-002407-25cawzi0	214	59	3	3	CD
cord-002407-25cawzi0	214	60	)	)	-RRB-
cord-002407-25cawzi0	214	61	[	[	-LRB-
cord-002407-25cawzi0	214	62	48	48	CD
cord-002407-25cawzi0	214	63	]	]	-RRB-
cord-002407-25cawzi0	214	64	.	.	.
cord-002407-25cawzi0	215	1	The	the	DT
cord-002407-25cawzi0	215	2	goal	goal	NN
cord-002407-25cawzi0	215	3	to	to	TO
cord-002407-25cawzi0	215	4	generate	generate	VB
cord-002407-25cawzi0	215	5	vRNA	vrna	RP
cord-002407-25cawzi0	215	6	in	in	IN
cord-002407-25cawzi0	215	7	vivo	vivo	NN
cord-002407-25cawzi0	215	8	from	from	IN
cord-002407-25cawzi0	215	9	cloned	clone	VBN
cord-002407-25cawzi0	215	10	complementary	complementary	JJ
cord-002407-25cawzi0	215	11	(	(	-LRB-
cord-002407-25cawzi0	215	12	c)DNAs	c)dna	NNS
cord-002407-25cawzi0	215	13	was	be	VBD
cord-002407-25cawzi0	215	14	achieved	achieve	VBN
cord-002407-25cawzi0	215	15	when	when	WRB
cord-002407-25cawzi0	215	16	the	the	DT
cord-002407-25cawzi0	215	17	RNA	RNA	NNP
cord-002407-25cawzi0	215	18	polymerase	polymerase	NN
cord-002407-25cawzi0	215	19	I	-PRON-	PRP
cord-002407-25cawzi0	215	20	(	(	-LRB-
cord-002407-25cawzi0	215	21	Pol	Pol	NNP
cord-002407-25cawzi0	215	22	I	i	CD
cord-002407-25cawzi0	215	23	)	)	-RRB-
cord-002407-25cawzi0	215	24	system	system	NN
cord-002407-25cawzi0	215	25	for	for	IN
cord-002407-25cawzi0	215	26	influenza	influenza	NN
cord-002407-25cawzi0	215	27	vRNA	vrna	JJ
cord-002407-25cawzi0	215	28	synthesis	synthesis	NN
cord-002407-25cawzi0	215	29	was	be	VBD
cord-002407-25cawzi0	215	30	established	establish	VBN
cord-002407-25cawzi0	215	31	[	[	-LRB-
cord-002407-25cawzi0	215	32	148	148	CD
cord-002407-25cawzi0	215	33	,	,	,
cord-002407-25cawzi0	215	34	149	149	CD
cord-002407-25cawzi0	215	35	]	]	-RRB-
cord-002407-25cawzi0	215	36	.	.	.
cord-002407-25cawzi0	216	1	Pol	Pol	NNP
cord-002407-25cawzi0	216	2	I	-PRON-	PRP
cord-002407-25cawzi0	216	3	is	be	VBZ
cord-002407-25cawzi0	216	4	a	a	DT
cord-002407-25cawzi0	216	5	nuclear	nuclear	JJ
cord-002407-25cawzi0	216	6	enzyme	enzyme	NN
cord-002407-25cawzi0	216	7	that	that	WDT
cord-002407-25cawzi0	216	8	transcribes	transcribe	VBZ
cord-002407-25cawzi0	216	9	ribosomal	ribosomal	NN
cord-002407-25cawzi0	216	10	(	(	-LRB-
cord-002407-25cawzi0	216	11	r)RNA	r)RNA	NNS
cord-002407-25cawzi0	216	12	,	,	,
cord-002407-25cawzi0	216	13	which	which	WDT
cord-002407-25cawzi0	216	14	like	like	IN
cord-002407-25cawzi0	216	15	influenza	influenza	NN
cord-002407-25cawzi0	216	16	vRNA	vRNA	:
cord-002407-25cawzi0	216	17	does	do	VBZ
cord-002407-25cawzi0	216	18	not	not	RB
cord-002407-25cawzi0	216	19	contain	contain	VB
cord-002407-25cawzi0	216	20	a	a	DT
cord-002407-25cawzi0	216	21	cap	cap	NN
cord-002407-25cawzi0	216	22	structure	structure	NN
cord-002407-25cawzi0	216	23	on	on	IN
cord-002407-25cawzi0	216	24	the	the	DT
cord-002407-25cawzi0	216	25	5	5	CD
cord-002407-25cawzi0	216	26	or	or	CC
cord-002407-25cawzi0	216	27	poly	poly	NN
cord-002407-25cawzi0	216	28	(	(	-LRB-
cord-002407-25cawzi0	216	29	A	a	NN
cord-002407-25cawzi0	216	30	)	)	-RRB-
cord-002407-25cawzi0	216	31	structures	structure	NNS
cord-002407-25cawzi0	216	32	on	on	IN
cord-002407-25cawzi0	216	33	the	the	DT
cord-002407-25cawzi0	216	34	3	3	CD
cord-002407-25cawzi0	216	35	ends	end	NNS
cord-002407-25cawzi0	216	36	[	[	-LRB-
cord-002407-25cawzi0	216	37	150	150	CD
cord-002407-25cawzi0	216	38	,	,	,
cord-002407-25cawzi0	216	39	151	151	CD
cord-002407-25cawzi0	216	40	]	]	-RRB-
cord-002407-25cawzi0	216	41	.	.	.
cord-002407-25cawzi0	217	1	Importantly	importantly	RB
cord-002407-25cawzi0	217	2	,	,	,
cord-002407-25cawzi0	217	3	Pol	Pol	NNP
cord-002407-25cawzi0	217	4	I	-PRON-	PRP
cord-002407-25cawzi0	217	5	initiates	initiate	VBZ
cord-002407-25cawzi0	217	6	and	and	CC
cord-002407-25cawzi0	217	7	terminates	terminate	VBZ
cord-002407-25cawzi0	217	8	transcription	transcription	NN
cord-002407-25cawzi0	217	9	at	at	IN
cord-002407-25cawzi0	217	10	defined	define	VBN
cord-002407-25cawzi0	217	11	promoter	promoter	NN
cord-002407-25cawzi0	217	12	and	and	CC
cord-002407-25cawzi0	217	13	terminator	terminator	NN
cord-002407-25cawzi0	217	14	sequences	sequence	NNS
cord-002407-25cawzi0	217	15	allowing	allow	VBG
cord-002407-25cawzi0	217	16	the	the	DT
cord-002407-25cawzi0	217	17	generation	generation	NN
cord-002407-25cawzi0	217	18	of	of	IN
cord-002407-25cawzi0	217	19	vRNAs	vrna	NNS
cord-002407-25cawzi0	217	20	without	without	IN
cord-002407-25cawzi0	217	21	additional	additional	JJ
cord-002407-25cawzi0	217	22	nucleotides	nucleotide	NNS
cord-002407-25cawzi0	217	23	at	at	IN
cord-002407-25cawzi0	217	24	their	-PRON-	PRP$
cord-002407-25cawzi0	217	25	5	5	CD
cord-002407-25cawzi0	217	26	or	or	CC
cord-002407-25cawzi0	217	27	3	3	CD
cord-002407-25cawzi0	217	28	ends	end	NNS
cord-002407-25cawzi0	217	29	,	,	,
cord-002407-25cawzi0	217	30	which	which	WDT
cord-002407-25cawzi0	217	31	is	be	VBZ
cord-002407-25cawzi0	217	32	required	require	VBN
cord-002407-25cawzi0	217	33	for	for	IN
cord-002407-25cawzi0	217	34	efficient	efficient	JJ
cord-002407-25cawzi0	217	35	generation	generation	NN
cord-002407-25cawzi0	217	36	of	of	IN
cord-002407-25cawzi0	217	37	recombinant	recombinant	JJ
cord-002407-25cawzi0	217	38	viruses	virus	NNS
cord-002407-25cawzi0	217	39	using	use	VBG
cord-002407-25cawzi0	217	40	reverse	reverse	JJ
cord-002407-25cawzi0	217	41	genetics	genetic	NNS
cord-002407-25cawzi0	217	42	.	.	.
cord-002407-25cawzi0	218	1	Nevertheless	nevertheless	RB
cord-002407-25cawzi0	218	2	,	,	,
cord-002407-25cawzi0	218	3	the	the	DT
cord-002407-25cawzi0	218	4	Pol	Pol	NNP
cord-002407-25cawzi0	218	5	I	I	NNP
cord-002407-25cawzi0	218	6	promoter	promoter	NN
cord-002407-25cawzi0	218	7	is	be	VBZ
cord-002407-25cawzi0	218	8	species	specie	NNS
cord-002407-25cawzi0	218	9	specific	specific	JJ
cord-002407-25cawzi0	218	10	[	[	-LRB-
cord-002407-25cawzi0	218	11	152	152	CD
cord-002407-25cawzi0	218	12	,	,	,
cord-002407-25cawzi0	218	13	153	153	CD
cord-002407-25cawzi0	218	14	]	]	-RRB-
cord-002407-25cawzi0	218	15	and	and	CC
cord-002407-25cawzi0	218	16	was	be	VBD
cord-002407-25cawzi0	218	17	originally	originally	RB
cord-002407-25cawzi0	218	18	established	establish	VBN
cord-002407-25cawzi0	218	19	for	for	IN
cord-002407-25cawzi0	218	20	influenza	influenza	NN
cord-002407-25cawzi0	218	21	rescue	rescue	NN
cord-002407-25cawzi0	218	22	in	in	IN
cord-002407-25cawzi0	218	23	human	human	JJ
cord-002407-25cawzi0	218	24	cells	cell	NNS
cord-002407-25cawzi0	218	25	[	[	-LRB-
cord-002407-25cawzi0	218	26	135	135	CD
cord-002407-25cawzi0	218	27	,	,	,
cord-002407-25cawzi0	218	28	140	140	CD
cord-002407-25cawzi0	218	29	,	,	,
cord-002407-25cawzi0	218	30	149	149	CD
cord-002407-25cawzi0	218	31	,	,	,
cord-002407-25cawzi0	218	32	154	154	CD
cord-002407-25cawzi0	218	33	]	]	-RRB-
cord-002407-25cawzi0	218	34	.	.	.
cord-002407-25cawzi0	219	1	Currently	currently	RB
cord-002407-25cawzi0	219	2	,	,	,
cord-002407-25cawzi0	219	3	the	the	DT
cord-002407-25cawzi0	219	4	Pol	Pol	NNP
cord-002407-25cawzi0	219	5	I	I	NNP
cord-002407-25cawzi0	219	6	promoters	promoter	NNS
cord-002407-25cawzi0	219	7	of	of	IN
cord-002407-25cawzi0	219	8	different	different	JJ
cord-002407-25cawzi0	219	9	species	specie	NNS
cord-002407-25cawzi0	219	10	have	have	VBP
cord-002407-25cawzi0	219	11	been	be	VBN
cord-002407-25cawzi0	219	12	identified	identify	VBN
cord-002407-25cawzi0	219	13	,	,	,
cord-002407-25cawzi0	219	14	allowing	allow	VBG
cord-002407-25cawzi0	219	15	the	the	DT
cord-002407-25cawzi0	219	16	generation	generation	NN
cord-002407-25cawzi0	219	17	of	of	IN
cord-002407-25cawzi0	219	18	recombinant	recombinant	JJ
cord-002407-25cawzi0	219	19	influenza	influenza	NN
cord-002407-25cawzi0	219	20	viruses	virus	NNS
cord-002407-25cawzi0	219	21	using	use	VBG
cord-002407-25cawzi0	219	22	reverse	reverse	JJ
cord-002407-25cawzi0	219	23	genetics	genetics	NN
cord-002407-25cawzi0	219	24	techniques	technique	NNS
cord-002407-25cawzi0	219	25	in	in	IN
cord-002407-25cawzi0	219	26	avian	avian	JJ
cord-002407-25cawzi0	219	27	,	,	,
cord-002407-25cawzi0	219	28	canine	canine	JJ
cord-002407-25cawzi0	219	29	,	,	,
cord-002407-25cawzi0	219	30	equine	equine	JJ
cord-002407-25cawzi0	219	31	or	or	CC
cord-002407-25cawzi0	219	32	murine	murine	JJ
cord-002407-25cawzi0	219	33	cells	cell	NNS
cord-002407-25cawzi0	219	34	lines	line	NNS
cord-002407-25cawzi0	219	35	[	[	-LRB-
cord-002407-25cawzi0	219	36	155	155	CD
cord-002407-25cawzi0	219	37	]	]	-RRB-
cord-002407-25cawzi0	219	38	[	[	-LRB-
cord-002407-25cawzi0	219	39	156	156	CD
cord-002407-25cawzi0	219	40	]	]	-RRB-
cord-002407-25cawzi0	219	41	[	[	-LRB-
cord-002407-25cawzi0	219	42	157	157	CD
cord-002407-25cawzi0	219	43	]	]	-RRB-
cord-002407-25cawzi0	219	44	[	[	-LRB-
cord-002407-25cawzi0	219	45	158	158	CD
cord-002407-25cawzi0	219	46	]	]	-RRB-
cord-002407-25cawzi0	219	47	.	.	.
cord-002407-25cawzi0	220	1	Nevertheless	nevertheless	RB
cord-002407-25cawzi0	220	2	,	,	,
cord-002407-25cawzi0	220	3	the	the	DT
cord-002407-25cawzi0	220	4	Pol	Pol	NNP
cord-002407-25cawzi0	220	5	I	I	NNP
cord-002407-25cawzi0	220	6	promoter	promoter	NN
cord-002407-25cawzi0	220	7	is	be	VBZ
cord-002407-25cawzi0	220	8	species	specie	NNS
cord-002407-25cawzi0	220	9	specific	specific	JJ
cord-002407-25cawzi0	220	10	[	[	-LRB-
cord-002407-25cawzi0	220	11	152	152	CD
cord-002407-25cawzi0	220	12	,	,	,
cord-002407-25cawzi0	220	13	153	153	CD
cord-002407-25cawzi0	220	14	]	]	-RRB-
cord-002407-25cawzi0	220	15	and	and	CC
cord-002407-25cawzi0	220	16	was	be	VBD
cord-002407-25cawzi0	220	17	originally	originally	RB
cord-002407-25cawzi0	220	18	established	establish	VBN
cord-002407-25cawzi0	220	19	for	for	IN
cord-002407-25cawzi0	220	20	influenza	influenza	NN
cord-002407-25cawzi0	220	21	rescue	rescue	NN
cord-002407-25cawzi0	220	22	in	in	IN
cord-002407-25cawzi0	220	23	human	human	JJ
cord-002407-25cawzi0	220	24	cells	cell	NNS
cord-002407-25cawzi0	220	25	[	[	-LRB-
cord-002407-25cawzi0	220	26	135	135	CD
cord-002407-25cawzi0	220	27	,	,	,
cord-002407-25cawzi0	220	28	140	140	CD
cord-002407-25cawzi0	220	29	,	,	,
cord-002407-25cawzi0	220	30	149	149	CD
cord-002407-25cawzi0	220	31	,	,	,
cord-002407-25cawzi0	220	32	154	154	CD
cord-002407-25cawzi0	220	33	]	]	-RRB-
cord-002407-25cawzi0	220	34	.	.	.
cord-002407-25cawzi0	221	1	Currently	currently	RB
cord-002407-25cawzi0	221	2	,	,	,
cord-002407-25cawzi0	221	3	the	the	DT
cord-002407-25cawzi0	221	4	Pol	Pol	NNP
cord-002407-25cawzi0	221	5	I	I	NNP
cord-002407-25cawzi0	221	6	promoters	promoter	NNS
cord-002407-25cawzi0	221	7	of	of	IN
cord-002407-25cawzi0	221	8	different	different	JJ
cord-002407-25cawzi0	221	9	species	specie	NNS
cord-002407-25cawzi0	221	10	have	have	VBP
cord-002407-25cawzi0	221	11	been	be	VBN
cord-002407-25cawzi0	221	12	identified	identify	VBN
cord-002407-25cawzi0	221	13	,	,	,
cord-002407-25cawzi0	221	14	allowing	allow	VBG
cord-002407-25cawzi0	221	15	the	the	DT
cord-002407-25cawzi0	221	16	generation	generation	NN
cord-002407-25cawzi0	221	17	of	of	IN
cord-002407-25cawzi0	221	18	recombinant	recombinant	JJ
cord-002407-25cawzi0	221	19	influenza	influenza	NN
cord-002407-25cawzi0	221	20	viruses	virus	NNS
cord-002407-25cawzi0	221	21	using	use	VBG
cord-002407-25cawzi0	221	22	reverse	reverse	JJ
cord-002407-25cawzi0	221	23	genetics	genetics	NN
cord-002407-25cawzi0	221	24	techniques	technique	NNS
cord-002407-25cawzi0	221	25	in	in	IN
cord-002407-25cawzi0	221	26	avian	avian	JJ
cord-002407-25cawzi0	221	27	,	,	,
cord-002407-25cawzi0	221	28	canine	canine	JJ
cord-002407-25cawzi0	221	29	,	,	,
cord-002407-25cawzi0	221	30	equine	equine	JJ
cord-002407-25cawzi0	221	31	or	or	CC
cord-002407-25cawzi0	221	32	murine	murine	JJ
cord-002407-25cawzi0	221	33	cells	cell	NNS
cord-002407-25cawzi0	221	34	lines	line	NNS
cord-002407-25cawzi0	221	35	[	[	-LRB-
cord-002407-25cawzi0	221	36	155	155	CD
cord-002407-25cawzi0	221	37	]	]	-RRB-
cord-002407-25cawzi0	221	38	[	[	-LRB-
cord-002407-25cawzi0	221	39	156	156	CD
cord-002407-25cawzi0	221	40	]	]	-RRB-
cord-002407-25cawzi0	221	41	[	[	-LRB-
cord-002407-25cawzi0	221	42	157	157	CD
cord-002407-25cawzi0	221	43	]	]	-RRB-
cord-002407-25cawzi0	221	44	[	[	-LRB-
cord-002407-25cawzi0	221	45	158	158	CD
cord-002407-25cawzi0	221	46	]	]	-RRB-
cord-002407-25cawzi0	221	47	.	.	.
cord-002407-25cawzi0	222	1	Influenza	influenza	NN
cord-002407-25cawzi0	222	2	viruses	virus	NNS
cord-002407-25cawzi0	222	3	require	require	VBP
cord-002407-25cawzi0	222	4	the	the	DT
cord-002407-25cawzi0	222	5	presence	presence	NN
cord-002407-25cawzi0	222	6	of	of	IN
cord-002407-25cawzi0	222	7	eight	eight	CD
cord-002407-25cawzi0	222	8	vRNA	vrna	JJ
cord-002407-25cawzi0	222	9	segments	segment	NNS
cord-002407-25cawzi0	222	10	for	for	IN
cord-002407-25cawzi0	222	11	efficient	efficient	JJ
cord-002407-25cawzi0	222	12	virus	virus	NN
cord-002407-25cawzi0	222	13	fitness	fitness	NN
cord-002407-25cawzi0	222	14	and	and	CC
cord-002407-25cawzi0	222	15	successful	successful	JJ
cord-002407-25cawzi0	222	16	production	production	NN
cord-002407-25cawzi0	222	17	of	of	IN
cord-002407-25cawzi0	222	18	virion	virion	NN
cord-002407-25cawzi0	222	19	progeny	progeny	NN
cord-002407-25cawzi0	222	20	.	.	.
cord-002407-25cawzi0	223	1	The	the	DT
cord-002407-25cawzi0	223	2	initial	initial	JJ
cord-002407-25cawzi0	223	3	description	description	NN
cord-002407-25cawzi0	223	4	of	of	IN
cord-002407-25cawzi0	223	5	influenza	influenza	NN
cord-002407-25cawzi0	223	6	reverse	reverse	JJ
cord-002407-25cawzi0	223	7	genetics	genetic	NNS
cord-002407-25cawzi0	223	8	,	,	,
cord-002407-25cawzi0	223	9	originally	originally	RB
cord-002407-25cawzi0	223	10	established	establish	VBN
cord-002407-25cawzi0	223	11	in	in	IN
cord-002407-25cawzi0	223	12	1999	1999	CD
cord-002407-25cawzi0	223	13	for	for	IN
cord-002407-25cawzi0	223	14	IAV	IAV	NNP
cord-002407-25cawzi0	223	15	[	[	-LRB-
cord-002407-25cawzi0	223	16	154	154	CD
cord-002407-25cawzi0	223	17	,	,	,
cord-002407-25cawzi0	223	18	159	159	CD
cord-002407-25cawzi0	223	19	]	]	-RRB-
cord-002407-25cawzi0	223	20	,	,	,
cord-002407-25cawzi0	223	21	required	require	VBD
cord-002407-25cawzi0	223	22	the	the	DT
cord-002407-25cawzi0	223	23	use	use	NN
cord-002407-25cawzi0	223	24	of	of	IN
cord-002407-25cawzi0	223	25	12	12	CD
cord-002407-25cawzi0	223	26	plasmids	plasmid	NNS
cord-002407-25cawzi0	223	27	to	to	TO
cord-002407-25cawzi0	223	28	generate	generate	VB
cord-002407-25cawzi0	223	29	recombinant	recombinant	JJ
cord-002407-25cawzi0	223	30	influenza	influenza	NN
cord-002407-25cawzi0	223	31	viruses	virus	NNS
cord-002407-25cawzi0	223	32	:	:	:
cord-002407-25cawzi0	223	33	four	four	CD
cord-002407-25cawzi0	223	34	polymerase	polymerase	NN
cord-002407-25cawzi0	223	35	II	II	NNP
cord-002407-25cawzi0	223	36	(	(	-LRB-
cord-002407-25cawzi0	223	37	Pol	Pol	NNP
cord-002407-25cawzi0	223	38	II	II	NNP
cord-002407-25cawzi0	223	39	)	)	-RRB-
cord-002407-25cawzi0	223	40	protein	protein	NN
cord-002407-25cawzi0	223	41	expression	expression	NN
cord-002407-25cawzi0	223	42	plasmids	plasmid	NNS
cord-002407-25cawzi0	223	43	,	,	,
cord-002407-25cawzi0	223	44	encoding	encode	VBG
cord-002407-25cawzi0	223	45	the	the	DT
cord-002407-25cawzi0	223	46	viral	viral	JJ
cord-002407-25cawzi0	223	47	RdRp	rdrp	NN
cord-002407-25cawzi0	223	48	complex	complex	NN
cord-002407-25cawzi0	223	49	(	(	-LRB-
cord-002407-25cawzi0	223	50	PB2	PB2	NNP
cord-002407-25cawzi0	223	51	,	,	,
cord-002407-25cawzi0	223	52	PB1	PB1	NNP
cord-002407-25cawzi0	223	53	and	and	CC
cord-002407-25cawzi0	223	54	PA	PA	NNP
cord-002407-25cawzi0	223	55	)	)	-RRB-
cord-002407-25cawzi0	223	56	and	and	CC
cord-002407-25cawzi0	223	57	NP	NP	NNP
cord-002407-25cawzi0	223	58	for	for	IN
cord-002407-25cawzi0	223	59	vRNP	vrnp	NN
cord-002407-25cawzi0	223	60	reconstitution	reconstitution	NN
cord-002407-25cawzi0	223	61	;	;	:
cord-002407-25cawzi0	223	62	and	and	CC
cord-002407-25cawzi0	223	63	eight	eight	CD
cord-002407-25cawzi0	223	64	Pol	Pol	NNP
cord-002407-25cawzi0	223	65	I	i	NN
cord-002407-25cawzi0	223	66	-	-	HYPH
cord-002407-25cawzi0	223	67	driven	drive	VBN
cord-002407-25cawzi0	223	68	plasmids	plasmid	NNS
cord-002407-25cawzi0	223	69	for	for	IN
cord-002407-25cawzi0	223	70	expression	expression	NN
cord-002407-25cawzi0	223	71	of	of	IN
cord-002407-25cawzi0	223	72	the	the	DT
cord-002407-25cawzi0	223	73	eight	eight	CD
cord-002407-25cawzi0	223	74	vRNA	vrna	JJ
cord-002407-25cawzi0	223	75	segments	segment	NNS
cord-002407-25cawzi0	223	76	[	[	-LRB-
cord-002407-25cawzi0	223	77	154	154	CD
cord-002407-25cawzi0	223	78	,	,	,
cord-002407-25cawzi0	223	79	159	159	CD
cord-002407-25cawzi0	223	80	]	]	-RRB-
cord-002407-25cawzi0	223	81	.	.	.
cord-002407-25cawzi0	224	1	However	however	RB
cord-002407-25cawzi0	224	2	,	,	,
cord-002407-25cawzi0	224	3	it	-PRON-	PRP
cord-002407-25cawzi0	224	4	was	be	VBD
cord-002407-25cawzi0	224	5	later	later	RB
cord-002407-25cawzi0	224	6	described	describe	VBN
cord-002407-25cawzi0	224	7	that	that	IN
cord-002407-25cawzi0	224	8	Influenza	Influenza	NNP
cord-002407-25cawzi0	224	9	viruses	virus	NNS
cord-002407-25cawzi0	224	10	require	require	VBP
cord-002407-25cawzi0	224	11	the	the	DT
cord-002407-25cawzi0	224	12	presence	presence	NN
cord-002407-25cawzi0	224	13	of	of	IN
cord-002407-25cawzi0	224	14	eight	eight	CD
cord-002407-25cawzi0	224	15	vRNA	vrna	JJ
cord-002407-25cawzi0	224	16	segments	segment	NNS
cord-002407-25cawzi0	224	17	for	for	IN
cord-002407-25cawzi0	224	18	efficient	efficient	JJ
cord-002407-25cawzi0	224	19	virus	virus	NN
cord-002407-25cawzi0	224	20	fitness	fitness	NN
cord-002407-25cawzi0	224	21	and	and	CC
cord-002407-25cawzi0	224	22	successful	successful	JJ
cord-002407-25cawzi0	224	23	production	production	NN
cord-002407-25cawzi0	224	24	of	of	IN
cord-002407-25cawzi0	224	25	virion	virion	NN
cord-002407-25cawzi0	224	26	progeny	progeny	NN
cord-002407-25cawzi0	224	27	.	.	.
cord-002407-25cawzi0	225	1	The	the	DT
cord-002407-25cawzi0	225	2	initial	initial	JJ
cord-002407-25cawzi0	225	3	description	description	NN
cord-002407-25cawzi0	225	4	of	of	IN
cord-002407-25cawzi0	225	5	influenza	influenza	NN
cord-002407-25cawzi0	225	6	reverse	reverse	JJ
cord-002407-25cawzi0	225	7	genetics	genetic	NNS
cord-002407-25cawzi0	225	8	,	,	,
cord-002407-25cawzi0	225	9	originally	originally	RB
cord-002407-25cawzi0	225	10	established	establish	VBN
cord-002407-25cawzi0	225	11	in	in	IN
cord-002407-25cawzi0	225	12	1999	1999	CD
cord-002407-25cawzi0	225	13	for	for	IN
cord-002407-25cawzi0	225	14	IAV	IAV	NNP
cord-002407-25cawzi0	225	15	[	[	-LRB-
cord-002407-25cawzi0	225	16	154	154	CD
cord-002407-25cawzi0	225	17	,	,	,
cord-002407-25cawzi0	225	18	159	159	CD
cord-002407-25cawzi0	225	19	]	]	-RRB-
cord-002407-25cawzi0	225	20	,	,	,
cord-002407-25cawzi0	225	21	required	require	VBD
cord-002407-25cawzi0	225	22	the	the	DT
cord-002407-25cawzi0	225	23	use	use	NN
cord-002407-25cawzi0	225	24	of	of	IN
cord-002407-25cawzi0	225	25	12	12	CD
cord-002407-25cawzi0	225	26	plasmids	plasmid	NNS
cord-002407-25cawzi0	225	27	to	to	TO
cord-002407-25cawzi0	225	28	generate	generate	VB
cord-002407-25cawzi0	225	29	recombinant	recombinant	JJ
cord-002407-25cawzi0	225	30	influenza	influenza	NN
cord-002407-25cawzi0	225	31	viruses	virus	NNS
cord-002407-25cawzi0	225	32	:	:	:
cord-002407-25cawzi0	225	33	four	four	CD
cord-002407-25cawzi0	225	34	polymerase	polymerase	NN
cord-002407-25cawzi0	225	35	II	II	NNP
cord-002407-25cawzi0	225	36	(	(	-LRB-
cord-002407-25cawzi0	225	37	Pol	Pol	NNP
cord-002407-25cawzi0	225	38	II	II	NNP
cord-002407-25cawzi0	225	39	)	)	-RRB-
cord-002407-25cawzi0	225	40	protein	protein	NN
cord-002407-25cawzi0	225	41	expression	expression	NN
cord-002407-25cawzi0	225	42	plasmids	plasmid	NNS
cord-002407-25cawzi0	225	43	,	,	,
cord-002407-25cawzi0	225	44	encoding	encode	VBG
cord-002407-25cawzi0	225	45	the	the	DT
cord-002407-25cawzi0	225	46	viral	viral	JJ
cord-002407-25cawzi0	225	47	RdRp	rdrp	NN
cord-002407-25cawzi0	225	48	complex	complex	NN
cord-002407-25cawzi0	225	49	(	(	-LRB-
cord-002407-25cawzi0	225	50	PB2	PB2	NNP
cord-002407-25cawzi0	225	51	,	,	,
cord-002407-25cawzi0	225	52	PB1	PB1	NNP
cord-002407-25cawzi0	225	53	and	and	CC
cord-002407-25cawzi0	225	54	PA	PA	NNP
cord-002407-25cawzi0	225	55	)	)	-RRB-
cord-002407-25cawzi0	225	56	and	and	CC
cord-002407-25cawzi0	225	57	NP	NP	NNP
cord-002407-25cawzi0	225	58	for	for	IN
cord-002407-25cawzi0	225	59	vRNP	vrnp	NN
cord-002407-25cawzi0	225	60	reconstitution	reconstitution	NN
cord-002407-25cawzi0	225	61	;	;	:
cord-002407-25cawzi0	225	62	and	and	CC
cord-002407-25cawzi0	225	63	eight	eight	CD
cord-002407-25cawzi0	225	64	Pol	Pol	NNP
cord-002407-25cawzi0	225	65	I	i	NN
cord-002407-25cawzi0	225	66	-	-	HYPH
cord-002407-25cawzi0	225	67	driven	drive	VBN
cord-002407-25cawzi0	225	68	plasmids	plasmid	NNS
cord-002407-25cawzi0	225	69	for	for	IN
cord-002407-25cawzi0	225	70	expression	expression	NN
cord-002407-25cawzi0	225	71	of	of	IN
cord-002407-25cawzi0	225	72	the	the	DT
cord-002407-25cawzi0	225	73	eight	eight	CD
cord-002407-25cawzi0	225	74	vRNA	vrna	JJ
cord-002407-25cawzi0	225	75	segments	segment	NNS
cord-002407-25cawzi0	225	76	[	[	-LRB-
cord-002407-25cawzi0	225	77	154	154	CD
cord-002407-25cawzi0	225	78	,	,	,
cord-002407-25cawzi0	225	79	159	159	CD
cord-002407-25cawzi0	225	80	]	]	-RRB-
cord-002407-25cawzi0	225	81	.	.	.
cord-002407-25cawzi0	226	1	However	however	RB
cord-002407-25cawzi0	226	2	,	,	,
cord-002407-25cawzi0	226	3	it	-PRON-	PRP
cord-002407-25cawzi0	226	4	was	be	VBD
cord-002407-25cawzi0	226	5	later	later	RB
cord-002407-25cawzi0	226	6	described	describe	VBN
cord-002407-25cawzi0	226	7	that	that	IN
cord-002407-25cawzi0	226	8	only	only	RB
cord-002407-25cawzi0	226	9	eight	eight	CD
cord-002407-25cawzi0	226	10	ambisense	ambisense	NN
cord-002407-25cawzi0	226	11	and/or	and/or	CC
cord-002407-25cawzi0	226	12	bidirectional	bidirectional	JJ
cord-002407-25cawzi0	226	13	plasmids	plasmid	NNS
cord-002407-25cawzi0	226	14	were	be	VBD
cord-002407-25cawzi0	226	15	needed	need	VBN
cord-002407-25cawzi0	226	16	for	for	IN
cord-002407-25cawzi0	226	17	complete	complete	JJ
cord-002407-25cawzi0	226	18	reconstitution	reconstitution	NN
cord-002407-25cawzi0	226	19	of	of	IN
cord-002407-25cawzi0	226	20	influenza	influenza	NN
cord-002407-25cawzi0	226	21	viruses	virus	NNS
cord-002407-25cawzi0	226	22	(	(	-LRB-
cord-002407-25cawzi0	226	23	Figure	figure	NN
cord-002407-25cawzi0	226	24	3A	3a	CD
cord-002407-25cawzi0	226	25	)	)	-RRB-
cord-002407-25cawzi0	226	26	[	[	-LRB-
cord-002407-25cawzi0	226	27	150	150	CD
cord-002407-25cawzi0	226	28	,	,	,
cord-002407-25cawzi0	226	29	151	151	CD
cord-002407-25cawzi0	226	30	]	]	-RRB-
cord-002407-25cawzi0	226	31	.	.	.
cord-002407-25cawzi0	227	1	The	the	DT
cord-002407-25cawzi0	227	2	eight	eight	CD
cord-002407-25cawzi0	227	3	plasmid	plasmid	NN
cord-002407-25cawzi0	227	4	-	-	HYPH
cord-002407-25cawzi0	227	5	based	base	VBN
cord-002407-25cawzi0	227	6	rescue	rescue	NN
cord-002407-25cawzi0	227	7	system	system	NN
cord-002407-25cawzi0	227	8	is	be	VBZ
cord-002407-25cawzi0	227	9	now	now	RB
cord-002407-25cawzi0	227	10	the	the	DT
cord-002407-25cawzi0	227	11	most	most	RBS
cord-002407-25cawzi0	227	12	common	common	JJ
cord-002407-25cawzi0	227	13	method	method	NN
cord-002407-25cawzi0	227	14	for	for	IN
cord-002407-25cawzi0	227	15	the	the	DT
cord-002407-25cawzi0	227	16	generation	generation	NN
cord-002407-25cawzi0	227	17	of	of	IN
cord-002407-25cawzi0	227	18	recombinant	recombinant	JJ
cord-002407-25cawzi0	227	19	influenza	influenza	NN
cord-002407-25cawzi0	227	20	viruses	virus	NNS
cord-002407-25cawzi0	227	21	.	.	.
cord-002407-25cawzi0	228	1	Because	because	IN
cord-002407-25cawzi0	228	2	fewer	few	JJR
cord-002407-25cawzi0	228	3	plasmids	plasmid	NNS
cord-002407-25cawzi0	228	4	are	be	VBP
cord-002407-25cawzi0	228	5	required	require	VBN
cord-002407-25cawzi0	228	6	,	,	,
cord-002407-25cawzi0	228	7	the	the	DT
cord-002407-25cawzi0	228	8	eight	eight	CD
cord-002407-25cawzi0	228	9	-	-	HYPH
cord-002407-25cawzi0	228	10	plasmid	plasmid	NN
cord-002407-25cawzi0	228	11	approach	approach	NN
cord-002407-25cawzi0	228	12	is	be	VBZ
cord-002407-25cawzi0	228	13	more	more	RBR
cord-002407-25cawzi0	228	14	successful	successful	JJ
cord-002407-25cawzi0	228	15	than	than	IN
cord-002407-25cawzi0	228	16	the	the	DT
cord-002407-25cawzi0	228	17	initial	initial	JJ
cord-002407-25cawzi0	228	18	twelve	twelve	CD
cord-002407-25cawzi0	228	19	-	-	HYPH
cord-002407-25cawzi0	228	20	plasmid	plasmid	NN
cord-002407-25cawzi0	228	21	reverse	reverse	JJ
cord-002407-25cawzi0	228	22	genetic	genetic	JJ
cord-002407-25cawzi0	228	23	technique	technique	NN
cord-002407-25cawzi0	228	24	.	.	.
cord-002407-25cawzi0	229	1	The	the	DT
cord-002407-25cawzi0	229	2	core	core	NN
cord-002407-25cawzi0	229	3	of	of	IN
cord-002407-25cawzi0	229	4	the	the	DT
cord-002407-25cawzi0	229	5	eight	eight	CD
cord-002407-25cawzi0	229	6	-	-	HYPH
cord-002407-25cawzi0	229	7	plasmid	plasmid	NN
cord-002407-25cawzi0	229	8	rescue	rescue	NN
cord-002407-25cawzi0	229	9	system	system	NN
cord-002407-25cawzi0	229	10	is	be	VBZ
cord-002407-25cawzi0	229	11	that	that	IN
cord-002407-25cawzi0	229	12	each	each	DT
cord-002407-25cawzi0	229	13	plasmid	plasmid	NN
cord-002407-25cawzi0	229	14	contains	contain	VBZ
cord-002407-25cawzi0	229	15	an	an	DT
cord-002407-25cawzi0	229	16	"	"	``
cord-002407-25cawzi0	229	17	ambisense	ambisense	NN
cord-002407-25cawzi0	229	18	cassette	cassette	NN
cord-002407-25cawzi0	229	19	"	"	''
cord-002407-25cawzi0	229	20	that	that	WDT
cord-002407-25cawzi0	229	21	includes	include	VBZ
cord-002407-25cawzi0	229	22	RNA	RNA	NNP
cord-002407-25cawzi0	229	23	Pol	Pol	NNP
cord-002407-25cawzi0	229	24	I	I	NNP
cord-002407-25cawzi0	229	25	and/or	and/or	CC
cord-002407-25cawzi0	229	26	II	II	NNP
cord-002407-25cawzi0	229	27	sequences	sequence	NNS
cord-002407-25cawzi0	229	28	,	,	,
cord-002407-25cawzi0	229	29	which	which	WDT
cord-002407-25cawzi0	229	30	drives	drive	VBZ
cord-002407-25cawzi0	229	31	the	the	DT
cord-002407-25cawzi0	229	32	transcription	transcription	NN
cord-002407-25cawzi0	229	33	of	of	IN
cord-002407-25cawzi0	229	34	vRNAs	vRNAs	.
cord-002407-25cawzi0	230	1	(	(	-LRB-
cord-002407-25cawzi0	230	2	Pol	Pol	NNP
cord-002407-25cawzi0	230	3	I	I	NNP
cord-002407-25cawzi0	230	4	)	)	-RRB-
cord-002407-25cawzi0	230	5	and	and	CC
cord-002407-25cawzi0	230	6	protein	protein	NN
cord-002407-25cawzi0	230	7	(	(	-LRB-
cord-002407-25cawzi0	230	8	Pol	Pol	NNP
cord-002407-25cawzi0	230	9	II	II	NNP
cord-002407-25cawzi0	230	10	)	)	-RRB-
cord-002407-25cawzi0	230	11	expression	expression	NN
cord-002407-25cawzi0	230	12	from	from	IN
cord-002407-25cawzi0	230	13	the	the	DT
cord-002407-25cawzi0	230	14	same	same	JJ
cord-002407-25cawzi0	230	15	viral	viral	NN
cord-002407-25cawzi0	231	1	cDNAs	cDNAs	.
cord-002407-25cawzi0	232	1	(	(	-LRB-
cord-002407-25cawzi0	232	2	Figure	figure	NN
cord-002407-25cawzi0	232	3	3B	3b	CD
cord-002407-25cawzi0	232	4	)	)	-RRB-
cord-002407-25cawzi0	232	5	.	.	.
cord-002407-25cawzi0	233	1	Using	use	VBG
cord-002407-25cawzi0	233	2	a	a	DT
cord-002407-25cawzi0	233	3	similar	similar	JJ
cord-002407-25cawzi0	233	4	technology	technology	NN
cord-002407-25cawzi0	233	5	in	in	IN
cord-002407-25cawzi0	233	6	2002	2002	CD
cord-002407-25cawzi0	233	7	,	,	,
cord-002407-25cawzi0	233	8	this	this	DT
cord-002407-25cawzi0	233	9	reverse	reverse	JJ
cord-002407-25cawzi0	233	10	genetics	genetics	NN
cord-002407-25cawzi0	233	11	technique	technique	NN
cord-002407-25cawzi0	233	12	allowed	allow	VBD
cord-002407-25cawzi0	233	13	the	the	DT
cord-002407-25cawzi0	233	14	recovery	recovery	NN
cord-002407-25cawzi0	233	15	of	of	IN
cord-002407-25cawzi0	233	16	IBV	IBV	NNP
cord-002407-25cawzi0	233	17	entirely	entirely	RB
cord-002407-25cawzi0	233	18	from	from	IN
cord-002407-25cawzi0	233	19	ambisense	ambisense	NN
cord-002407-25cawzi0	233	20	plasmids	plasmid	NNS
cord-002407-25cawzi0	233	21	[	[	-LRB-
cord-002407-25cawzi0	233	22	13	13	CD
cord-002407-25cawzi0	233	23	,	,	,
cord-002407-25cawzi0	233	24	[	[	-LRB-
cord-002407-25cawzi0	233	25	160	160	CD
cord-002407-25cawzi0	233	26	]	]	-RRB-
cord-002407-25cawzi0	233	27	[	[	-LRB-
cord-002407-25cawzi0	233	28	161	161	CD
cord-002407-25cawzi0	233	29	]	]	-RRB-
cord-002407-25cawzi0	233	30	[	[	-LRB-
cord-002407-25cawzi0	233	31	162	162	CD
cord-002407-25cawzi0	233	32	]	]	-RRB-
cord-002407-25cawzi0	233	33	.	.	.
cord-002407-25cawzi0	234	1	Now	now	RB
cord-002407-25cawzi0	234	2	,	,	,
cord-002407-25cawzi0	234	3	IAV	IAV	NNP
cord-002407-25cawzi0	234	4	and	and	CC
cord-002407-25cawzi0	234	5	IBV	IBV	NNP
cord-002407-25cawzi0	234	6	reverse	reverse	VB
cord-002407-25cawzi0	234	7	genetics	genetics	NN
cord-002407-25cawzi0	234	8	techniques	technique	NNS
cord-002407-25cawzi0	234	9	are	be	VBP
cord-002407-25cawzi0	234	10	well	well	RB
cord-002407-25cawzi0	234	11	established	establish	VBN
cord-002407-25cawzi0	234	12	and	and	CC
cord-002407-25cawzi0	234	13	commonly	commonly	RB
cord-002407-25cawzi0	234	14	used	use	VBN
cord-002407-25cawzi0	234	15	in	in	IN
cord-002407-25cawzi0	234	16	multiple	multiple	JJ
cord-002407-25cawzi0	234	17	research	research	NN
cord-002407-25cawzi0	234	18	laboratories	laboratory	NNS
cord-002407-25cawzi0	234	19	for	for	IN
cord-002407-25cawzi0	234	20	different	different	JJ
cord-002407-25cawzi0	234	21	research	research	NN
cord-002407-25cawzi0	234	22	purposes	purpose	NNS
cord-002407-25cawzi0	234	23	.	.	.
cord-002407-25cawzi0	235	1	Influenza	influenza	NN
cord-002407-25cawzi0	235	2	reverse	reverse	JJ
cord-002407-25cawzi0	235	3	genetics	genetics	NN
cord-002407-25cawzi0	235	4	techniques	technique	NNS
cord-002407-25cawzi0	235	5	have	have	VBP
cord-002407-25cawzi0	235	6	had	have	VBN
cord-002407-25cawzi0	235	7	an	an	DT
cord-002407-25cawzi0	235	8	important	important	JJ
cord-002407-25cawzi0	235	9	effect	effect	NN
cord-002407-25cawzi0	235	10	on	on	IN
cord-002407-25cawzi0	235	11	expanding	expand	VBG
cord-002407-25cawzi0	235	12	our	-PRON-	PRP$
cord-002407-25cawzi0	235	13	knowledge	knowledge	NN
cord-002407-25cawzi0	235	14	of	of	IN
cord-002407-25cawzi0	235	15	the	the	DT
cord-002407-25cawzi0	235	16	molecular	molecular	JJ
cord-002407-25cawzi0	235	17	biology	biology	NN
cord-002407-25cawzi0	235	18	and	and	CC
cord-002407-25cawzi0	235	19	pathogenesis	pathogenesis	NN
cord-002407-25cawzi0	235	20	of	of	IN
cord-002407-25cawzi0	235	21	influenza	influenza	NN
cord-002407-25cawzi0	235	22	viruses	virus	NNS
cord-002407-25cawzi0	235	23	,	,	,
cord-002407-25cawzi0	235	24	allowing	allow	VBG
cord-002407-25cawzi0	235	25	researchers	researcher	NNS
cord-002407-25cawzi0	235	26	to	to	TO
cord-002407-25cawzi0	235	27	answer	answer	VB
cord-002407-25cawzi0	235	28	important	important	JJ
cord-002407-25cawzi0	235	29	questions	question	NNS
cord-002407-25cawzi0	235	30	in	in	IN
cord-002407-25cawzi0	235	31	the	the	DT
cord-002407-25cawzi0	235	32	biology	biology	NN
cord-002407-25cawzi0	235	33	of	of	IN
cord-002407-25cawzi0	235	34	IAV	IAV	NNP
cord-002407-25cawzi0	235	35	and	and	CC
cord-002407-25cawzi0	235	36	IBV	IBV	NNP
cord-002407-25cawzi0	235	37	that	that	WDT
cord-002407-25cawzi0	235	38	were	be	VBD
cord-002407-25cawzi0	235	39	not	not	RB
cord-002407-25cawzi0	235	40	possible	possible	JJ
cord-002407-25cawzi0	235	41	using	use	VBG
cord-002407-25cawzi0	235	42	conventional	conventional	JJ
cord-002407-25cawzi0	235	43	virological	virological	JJ
cord-002407-25cawzi0	235	44	or	or	CC
cord-002407-25cawzi0	235	45	biochemical	biochemical	JJ
cord-002407-25cawzi0	235	46	procedures	procedure	NNS
cord-002407-25cawzi0	235	47	[	[	-LRB-
cord-002407-25cawzi0	235	48	12	12	CD
cord-002407-25cawzi0	235	49	,	,	,
cord-002407-25cawzi0	235	50	144	144	CD
cord-002407-25cawzi0	235	51	,	,	,
cord-002407-25cawzi0	235	52	147	147	CD
cord-002407-25cawzi0	235	53	]	]	-RRB-
cord-002407-25cawzi0	235	54	.	.	.
cord-002407-25cawzi0	236	1	Scientists	scientist	NNS
cord-002407-25cawzi0	236	2	can	can	MD
cord-002407-25cawzi0	236	3	now	now	RB
cord-002407-25cawzi0	236	4	mutate	mutate	VB
cord-002407-25cawzi0	236	5	specific	specific	JJ
cord-002407-25cawzi0	236	6	nucleotides	nucleotide	NNS
cord-002407-25cawzi0	236	7	in	in	IN
cord-002407-25cawzi0	236	8	the	the	DT
cord-002407-25cawzi0	236	9	influenza	influenza	NN
cord-002407-25cawzi0	236	10	viral	viral	JJ
cord-002407-25cawzi0	236	11	genome	genome	NN
cord-002407-25cawzi0	236	12	to	to	TO
cord-002407-25cawzi0	236	13	elucidate	elucidate	VB
cord-002407-25cawzi0	236	14	the	the	DT
cord-002407-25cawzi0	236	15	nature	nature	NN
cord-002407-25cawzi0	236	16	of	of	IN
cord-002407-25cawzi0	236	17	regulatory	regulatory	JJ
cord-002407-25cawzi0	236	18	sequences	sequence	NNS
cord-002407-25cawzi0	236	19	or	or	CC
cord-002407-25cawzi0	236	20	the	the	DT
cord-002407-25cawzi0	236	21	contribution	contribution	NN
cord-002407-25cawzi0	236	22	of	of	IN
cord-002407-25cawzi0	236	23	specific	specific	JJ
cord-002407-25cawzi0	236	24	amino	amino	JJ
cord-002407-25cawzi0	236	25	acids	acid	NNS
cord-002407-25cawzi0	236	26	to	to	IN
cord-002407-25cawzi0	236	27	the	the	DT
cord-002407-25cawzi0	236	28	function	function	NN
cord-002407-25cawzi0	236	29	of	of	IN
cord-002407-25cawzi0	236	30	influenza	influenza	NN
cord-002407-25cawzi0	236	31	viral	viral	JJ
cord-002407-25cawzi0	236	32	proteins	protein	NNS
cord-002407-25cawzi0	236	33	.	.	.
cord-002407-25cawzi0	237	1	For	for	IN
cord-002407-25cawzi0	237	2	instance	instance	NN
cord-002407-25cawzi0	237	3	,	,	,
cord-002407-25cawzi0	237	4	reverse	reverse	VB
cord-002407-25cawzi0	237	5	genetics	genetics	NN
cord-002407-25cawzi0	237	6	technologies	technology	NNS
cord-002407-25cawzi0	237	7	have	have	VBP
cord-002407-25cawzi0	237	8	enabled	enable	VBN
cord-002407-25cawzi0	237	9	the	the	DT
cord-002407-25cawzi0	237	10	identification	identification	NN
cord-002407-25cawzi0	237	11	and	and	CC
cord-002407-25cawzi0	237	12	characterization	characterization	NN
cord-002407-25cawzi0	237	13	of	of	IN
cord-002407-25cawzi0	237	14	the	the	DT
cord-002407-25cawzi0	237	15	cis	cis	NNP
cord-002407-25cawzi0	237	16	-	-	HYPH
cord-002407-25cawzi0	237	17	acting	act	VBG
cord-002407-25cawzi0	237	18	elements	element	NNS
cord-002407-25cawzi0	237	19	required	require	VBN
cord-002407-25cawzi0	237	20	for	for	IN
cord-002407-25cawzi0	237	21	virus	virus	NN
cord-002407-25cawzi0	237	22	cell	cell	NN
cord-002407-25cawzi0	237	23	entry	entry	NN
cord-002407-25cawzi0	237	24	,	,	,
cord-002407-25cawzi0	237	25	uncoating	uncoating	NN
cord-002407-25cawzi0	237	26	,	,	,
cord-002407-25cawzi0	237	27	genome	genome	NN
cord-002407-25cawzi0	237	28	replication	replication	NN
cord-002407-25cawzi0	237	29	and	and	CC
cord-002407-25cawzi0	237	30	gene	gene	NN
cord-002407-25cawzi0	237	31	transcription	transcription	NN
cord-002407-25cawzi0	237	32	,	,	,
cord-002407-25cawzi0	237	33	encapsidation	encapsidation	NN
cord-002407-25cawzi0	237	34	,	,	,
cord-002407-25cawzi0	237	35	packaging	packaging	NN
cord-002407-25cawzi0	237	36	and	and	CC
cord-002407-25cawzi0	237	37	viral	viral	JJ
cord-002407-25cawzi0	237	38	release	release	NN
cord-002407-25cawzi0	237	39	[	[	-LRB-
cord-002407-25cawzi0	237	40	13	13	CD
cord-002407-25cawzi0	237	41	,	,	,
cord-002407-25cawzi0	237	42	135	135	CD
cord-002407-25cawzi0	237	43	,	,	,
cord-002407-25cawzi0	237	44	[	[	-LRB-
cord-002407-25cawzi0	237	45	163	163	CD
cord-002407-25cawzi0	237	46	]	]	-RRB-
cord-002407-25cawzi0	237	47	[	[	-LRB-
cord-002407-25cawzi0	237	48	164	164	CD
cord-002407-25cawzi0	237	49	]	]	-RRB-
cord-002407-25cawzi0	237	50	[	[	-LRB-
cord-002407-25cawzi0	237	51	165	165	CD
cord-002407-25cawzi0	237	52	]	]	-RRB-
cord-002407-25cawzi0	237	53	.	.	.
cord-002407-25cawzi0	238	1	Moreover	moreover	RB
cord-002407-25cawzi0	238	2	,	,	,
cord-002407-25cawzi0	238	3	by	by	IN
cord-002407-25cawzi0	238	4	engineering	engineer	VBG
cord-002407-25cawzi0	238	5	viral	viral	JJ
cord-002407-25cawzi0	238	6	vectors	vector	NNS
cord-002407-25cawzi0	238	7	suitable	suitable	JJ
cord-002407-25cawzi0	238	8	for	for	IN
cord-002407-25cawzi0	238	9	the	the	DT
cord-002407-25cawzi0	238	10	expression	expression	NN
cord-002407-25cawzi0	238	11	of	of	IN
cord-002407-25cawzi0	238	12	foreign	foreign	JJ
cord-002407-25cawzi0	238	13	proteins	protein	NNS
cord-002407-25cawzi0	238	14	in	in	IN
cord-002407-25cawzi0	238	15	infected	infected	JJ
cord-002407-25cawzi0	238	16	cells	cell	NNS
cord-002407-25cawzi0	238	17	,	,	,
cord-002407-25cawzi0	238	18	multiple	multiple	JJ
cord-002407-25cawzi0	238	19	recombinant	recombinant	JJ
cord-002407-25cawzi0	238	20	influenza	influenza	NN
cord-002407-25cawzi0	238	21	viruses	virus	NNS
cord-002407-25cawzi0	238	22	harboring	harbor	VBG
cord-002407-25cawzi0	238	23	reporter	reporter	NN
cord-002407-25cawzi0	238	24	fluorescent	fluorescent	NN
cord-002407-25cawzi0	238	25	and/or	and/or	CC
cord-002407-25cawzi0	238	26	luminescent	luminescent	JJ
cord-002407-25cawzi0	238	27	genes	gene	NNS
cord-002407-25cawzi0	238	28	have	have	VBP
cord-002407-25cawzi0	238	29	been	be	VBN
cord-002407-25cawzi0	238	30	generated	generate	VBN
cord-002407-25cawzi0	238	31	and	and	CC
cord-002407-25cawzi0	238	32	used	use	VBN
cord-002407-25cawzi0	238	33	to	to	TO
cord-002407-25cawzi0	238	34	identify	identify	VB
cord-002407-25cawzi0	238	35	antivirals	antiviral	NNS
cord-002407-25cawzi0	238	36	or	or	CC
cord-002407-25cawzi0	238	37	NAbs	NAbs	NNP
cord-002407-25cawzi0	238	38	in	in	IN
cord-002407-25cawzi0	238	39	vitro	vitro	FW
cord-002407-25cawzi0	238	40	and/or	and/or	CC
cord-002407-25cawzi0	238	41	in	in	IN
cord-002407-25cawzi0	238	42	vivo	vivo	NNP
cord-002407-25cawzi0	238	43	[	[	-LRB-
cord-002407-25cawzi0	238	44	142	142	CD
cord-002407-25cawzi0	238	45	,	,	,
cord-002407-25cawzi0	238	46	146	146	CD
cord-002407-25cawzi0	238	47	,	,	,
cord-002407-25cawzi0	238	48	147	147	CD
cord-002407-25cawzi0	238	49	]	]	-RRB-
cord-002407-25cawzi0	238	50	.	.	.
cord-002407-25cawzi0	239	1	Finally	finally	RB
cord-002407-25cawzi0	239	2	,	,	,
cord-002407-25cawzi0	239	3	reverse	reverse	VB
cord-002407-25cawzi0	239	4	genetics	genetic	NNS
cord-002407-25cawzi0	239	5	have	have	VBP
cord-002407-25cawzi0	239	6	allowed	allow	VBN
cord-002407-25cawzi0	239	7	the	the	DT
cord-002407-25cawzi0	239	8	creation	creation	NN
cord-002407-25cawzi0	239	9	of	of	IN
cord-002407-25cawzi0	239	10	single	single	JJ
cord-002407-25cawzi0	239	11	-	-	HYPH
cord-002407-25cawzi0	239	12	cycle	cycle	NN
cord-002407-25cawzi0	239	13	infectious	infectious	JJ
cord-002407-25cawzi0	239	14	IAVs	iav	NNS
cord-002407-25cawzi0	239	15	(	(	-LRB-
cord-002407-25cawzi0	239	16	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	239	17	)	)	-RRB-
cord-002407-25cawzi0	239	18	that	that	WDT
cord-002407-25cawzi0	239	19	are	be	VBP
cord-002407-25cawzi0	239	20	restricted	restrict	VBN
cord-002407-25cawzi0	239	21	to	to	IN
cord-002407-25cawzi0	239	22	one	one	CD
cord-002407-25cawzi0	239	23	cycle	cycle	NN
cord-002407-25cawzi0	239	24	of	of	IN
cord-002407-25cawzi0	239	25	replication	replication	NN
cord-002407-25cawzi0	239	26	in	in	IN
cord-002407-25cawzi0	239	27	parental	parental	JJ
cord-002407-25cawzi0	239	28	cell	cell	NN
cord-002407-25cawzi0	239	29	lines	line	NNS
cord-002407-25cawzi0	239	30	.	.	.
cord-002407-25cawzi0	240	1	However	however	RB
cord-002407-25cawzi0	240	2	,	,	,
cord-002407-25cawzi0	240	3	in	in	IN
cord-002407-25cawzi0	240	4	complementing	complement	VBG
cord-002407-25cawzi0	240	5	cell	cell	NN
cord-002407-25cawzi0	240	6	lines	line	NNS
cord-002407-25cawzi0	240	7	,	,	,
cord-002407-25cawzi0	240	8	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	240	9	can	can	MD
cord-002407-25cawzi0	240	10	replicate	replicate	VB
cord-002407-25cawzi0	240	11	efficiently	efficiently	RB
cord-002407-25cawzi0	240	12	and	and	CC
cord-002407-25cawzi0	240	13	to	to	IN
cord-002407-25cawzi0	240	14	levels	level	NNS
cord-002407-25cawzi0	240	15	comparable	comparable	JJ
cord-002407-25cawzi0	240	16	to	to	IN
cord-002407-25cawzi0	240	17	WT	WT	NNP
cord-002407-25cawzi0	240	18	forms	form	NNS
cord-002407-25cawzi0	240	19	of	of	IN
cord-002407-25cawzi0	240	20	influenza	influenza	NN
cord-002407-25cawzi0	240	21	viruses	virus	NNS
cord-002407-25cawzi0	240	22	[	[	-LRB-
cord-002407-25cawzi0	240	23	144	144	CD
cord-002407-25cawzi0	240	24	]	]	-RRB-
cord-002407-25cawzi0	240	25	.	.	.
cord-002407-25cawzi0	241	1	Highly	highly	RB
cord-002407-25cawzi0	241	2	virulent	virulent	JJ
cord-002407-25cawzi0	241	3	IAV	IAV	NNP
cord-002407-25cawzi0	241	4	have	have	VBP
cord-002407-25cawzi0	241	5	the	the	DT
cord-002407-25cawzi0	241	6	potential	potential	NN
cord-002407-25cawzi0	241	7	to	to	TO
cord-002407-25cawzi0	241	8	pose	pose	VB
cord-002407-25cawzi0	241	9	a	a	DT
cord-002407-25cawzi0	241	10	greater	great	JJR
cord-002407-25cawzi0	241	11	human	human	JJ
cord-002407-25cawzi0	241	12	threat	threat	NN
cord-002407-25cawzi0	241	13	than	than	IN
cord-002407-25cawzi0	241	14	many	many	JJ
cord-002407-25cawzi0	241	15	other	other	JJ
cord-002407-25cawzi0	241	16	Biosafety	Biosafety	NNP
cord-002407-25cawzi0	241	17	Level	Level	NNP
cord-002407-25cawzi0	241	18	(	(	-LRB-
cord-002407-25cawzi0	241	19	BSL)-3	bsl)-3	NN
cord-002407-25cawzi0	241	20	and	and	CC
cord-002407-25cawzi0	241	21	BSL-4	BSL-4	NNP
cord-002407-25cawzi0	241	22	pathogens	pathogen	NNS
cord-002407-25cawzi0	241	23	because	because	IN
cord-002407-25cawzi0	241	24	of	of	IN
cord-002407-25cawzi0	241	25	their	-PRON-	PRP$
cord-002407-25cawzi0	241	26	efficient	efficient	JJ
cord-002407-25cawzi0	241	27	transmission	transmission	NN
cord-002407-25cawzi0	241	28	and	and	CC
cord-002407-25cawzi0	241	29	limited	limited	JJ
cord-002407-25cawzi0	241	30	therapeutic	therapeutic	JJ
cord-002407-25cawzi0	241	31	options	option	NNS
cord-002407-25cawzi0	241	32	[	[	-LRB-
cord-002407-25cawzi0	241	33	47	47	CD
cord-002407-25cawzi0	241	34	]	]	-RRB-
cord-002407-25cawzi0	241	35	.	.	.
cord-002407-25cawzi0	242	1	Traditional	traditional	JJ
cord-002407-25cawzi0	242	2	immunological	immunological	JJ
cord-002407-25cawzi0	242	3	approaches	approach	NNS
cord-002407-25cawzi0	242	4	(	(	-LRB-
cord-002407-25cawzi0	242	5	e.g.	e.g.	RB
cord-002407-25cawzi0	242	6	,	,	,
cord-002407-25cawzi0	242	7	HAI	HAI	NNP
cord-002407-25cawzi0	242	8	or	or	CC
cord-002407-25cawzi0	242	9	microneutralization	microneutralization	NN
cord-002407-25cawzi0	242	10	assays	assay	NNS
cord-002407-25cawzi0	242	11	)	)	-RRB-
cord-002407-25cawzi0	243	1	to	to	TO
cord-002407-25cawzi0	243	2	identify	identify	VB
cord-002407-25cawzi0	243	3	the	the	DT
cord-002407-25cawzi0	243	4	presence	presence	NN
cord-002407-25cawzi0	243	5	of	of	IN
cord-002407-25cawzi0	243	6	IAV	IAV	NNP
cord-002407-25cawzi0	243	7	NAbs	NAbs	NNP
cord-002407-25cawzi0	244	1	rely	rely	VB
cord-002407-25cawzi0	244	2	on	on	IN
cord-002407-25cawzi0	244	3	the	the	DT
cord-002407-25cawzi0	244	4	manipulation	manipulation	NN
cord-002407-25cawzi0	244	5	of	of	IN
cord-002407-25cawzi0	244	6	live	live	JJ
cord-002407-25cawzi0	244	7	forms	form	NNS
cord-002407-25cawzi0	244	8	of	of	IN
cord-002407-25cawzi0	244	9	viruses	virus	NNS
cord-002407-25cawzi0	244	10	and	and	CC
cord-002407-25cawzi0	244	11	need	need	VB
cord-002407-25cawzi0	244	12	the	the	DT
cord-002407-25cawzi0	244	13	use	use	NN
cord-002407-25cawzi0	244	14	of	of	IN
cord-002407-25cawzi0	244	15	special	special	JJ
cord-002407-25cawzi0	244	16	BSL	BSL	NNP
cord-002407-25cawzi0	244	17	conditions	condition	NNS
cord-002407-25cawzi0	244	18	.	.	.
cord-002407-25cawzi0	245	1	Thus	thus	RB
cord-002407-25cawzi0	245	2	,	,	,
cord-002407-25cawzi0	245	3	novel	novel	NN
cord-002407-25cawzi0	245	4	approaches	approach	NNS
cord-002407-25cawzi0	245	5	that	that	WDT
cord-002407-25cawzi0	245	6	allow	allow	VBP
cord-002407-25cawzi0	245	7	the	the	DT
cord-002407-25cawzi0	245	8	detection	detection	NN
cord-002407-25cawzi0	245	9	of	of	IN
cord-002407-25cawzi0	245	10	viral	viral	JJ
cord-002407-25cawzi0	245	11	NAbs	NAbs	NNP
cord-002407-25cawzi0	245	12	without	without	IN
cord-002407-25cawzi0	245	13	the	the	DT
cord-002407-25cawzi0	245	14	use	use	NN
cord-002407-25cawzi0	245	15	of	of	IN
cord-002407-25cawzi0	245	16	live	live	JJ
cord-002407-25cawzi0	245	17	forms	form	NNS
cord-002407-25cawzi0	245	18	of	of	IN
cord-002407-25cawzi0	245	19	IAVs	iav	NNS
cord-002407-25cawzi0	245	20	and	and	CC
cord-002407-25cawzi0	245	21	highly	highly	RB
cord-002407-25cawzi0	245	22	contained	contain	VBD
cord-002407-25cawzi0	245	23	BSL	BSL	NNP
cord-002407-25cawzi0	245	24	laboratories	laboratory	NNS
cord-002407-25cawzi0	245	25	would	would	MD
cord-002407-25cawzi0	245	26	facilitate	facilitate	VB
cord-002407-25cawzi0	245	27	these	these	DT
cord-002407-25cawzi0	245	28	serological	serological	JJ
cord-002407-25cawzi0	245	29	assays	assay	NNS
cord-002407-25cawzi0	245	30	.	.	.
cord-002407-25cawzi0	246	1	In	in	IN
cord-002407-25cawzi0	246	2	this	this	DT
cord-002407-25cawzi0	246	3	regard	regard	NN
cord-002407-25cawzi0	246	4	and	and	CC
cord-002407-25cawzi0	246	5	because	because	IN
cord-002407-25cawzi0	246	6	of	of	IN
cord-002407-25cawzi0	246	7	their	-PRON-	PRP$
cord-002407-25cawzi0	246	8	safety	safety	NN
cord-002407-25cawzi0	246	9	profile	profile	NN
cord-002407-25cawzi0	246	10	,	,	,
cord-002407-25cawzi0	246	11	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	246	12	represent	represent	VBP
cord-002407-25cawzi0	246	13	an	an	DT
cord-002407-25cawzi0	246	14	excellent	excellent	JJ
cord-002407-25cawzi0	246	15	alternative	alternative	NN
cord-002407-25cawzi0	246	16	to	to	TO
cord-002407-25cawzi0	246	17	identify	identify	VB
cord-002407-25cawzi0	246	18	new	new	JJ
cord-002407-25cawzi0	246	19	antivirals	antiviral	NNS
cord-002407-25cawzi0	246	20	and/or	and/or	CC
cord-002407-25cawzi0	247	1	NAbs	NAbs	NNP
cord-002407-25cawzi0	247	2	[	[	-LRB-
cord-002407-25cawzi0	247	3	144	144	CD
cord-002407-25cawzi0	247	4	]	]	-RRB-
cord-002407-25cawzi0	247	5	.	.	.
cord-002407-25cawzi0	248	1	Moreover	moreover	RB
cord-002407-25cawzi0	248	2	,	,	,
cord-002407-25cawzi0	248	3	several	several	JJ
cord-002407-25cawzi0	248	4	sciIAVs	sciiavs	CD
cord-002407-25cawzi0	248	5	have	have	VBP
cord-002407-25cawzi0	248	6	been	be	VBN
cord-002407-25cawzi0	248	7	shown	show	VBN
cord-002407-25cawzi0	248	8	to	to	TO
cord-002407-25cawzi0	248	9	represent	represent	VB
cord-002407-25cawzi0	248	10	an	an	DT
cord-002407-25cawzi0	248	11	excellent	excellent	JJ
cord-002407-25cawzi0	248	12	option	option	NN
cord-002407-25cawzi0	248	13	for	for	IN
cord-002407-25cawzi0	248	14	their	-PRON-	PRP$
cord-002407-25cawzi0	248	15	implementation	implementation	NN
cord-002407-25cawzi0	248	16	as	as	RB
cord-002407-25cawzi0	248	17	safe	safe	JJ
cord-002407-25cawzi0	248	18	,	,	,
cord-002407-25cawzi0	248	19	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	248	20	and	and	CC
cord-002407-25cawzi0	248	21	protective	protective	JJ
cord-002407-25cawzi0	248	22	vaccines	vaccine	NNS
cord-002407-25cawzi0	248	23	and/or	and/or	CC
cord-002407-25cawzi0	248	24	vaccine	vaccine	NN
cord-002407-25cawzi0	248	25	vectors	vector	NNS
cord-002407-25cawzi0	248	26	[	[	-LRB-
cord-002407-25cawzi0	248	27	69	69	CD
cord-002407-25cawzi0	248	28	,	,	,
cord-002407-25cawzi0	248	29	144	144	CD
cord-002407-25cawzi0	248	30	]	]	-RRB-
cord-002407-25cawzi0	248	31	.	.	.
cord-002407-25cawzi0	249	1	Influenza	influenza	NN
cord-002407-25cawzi0	249	2	plasmid	plasmid	NN
cord-002407-25cawzi0	249	3	-	-	HYPH
cord-002407-25cawzi0	249	4	based	base	VBN
cord-002407-25cawzi0	249	5	reverse	reverse	NN
cord-002407-25cawzi0	249	6	genetics	genetic	NNS
cord-002407-25cawzi0	249	7	represent	represent	VBP
cord-002407-25cawzi0	249	8	a	a	DT
cord-002407-25cawzi0	249	9	better	well	JJR
cord-002407-25cawzi0	249	10	alternative	alternative	NN
cord-002407-25cawzi0	249	11	to	to	TO
cord-002407-25cawzi0	249	12	circumvent	circumvent	VB
cord-002407-25cawzi0	249	13	the	the	DT
cord-002407-25cawzi0	249	14	process	process	NN
cord-002407-25cawzi0	249	15	of	of	IN
cord-002407-25cawzi0	249	16	generating	generate	VBG
cord-002407-25cawzi0	249	17	reassortant	reassortant	JJ
cord-002407-25cawzi0	249	18	virus	virus	NN
cord-002407-25cawzi0	249	19	by	by	IN
cord-002407-25cawzi0	249	20	co	co	NN
cord-002407-25cawzi0	249	21	-	-	NN
cord-002407-25cawzi0	249	22	infection	infection	NN
cord-002407-25cawzi0	249	23	of	of	IN
cord-002407-25cawzi0	249	24	chicken	chicken	NN
cord-002407-25cawzi0	249	25	embryonated	embryonate	VBN
cord-002407-25cawzi0	249	26	eggs	egg	NNS
cord-002407-25cawzi0	249	27	for	for	IN
cord-002407-25cawzi0	249	28	the	the	DT
cord-002407-25cawzi0	249	29	generation	generation	NN
cord-002407-25cawzi0	249	30	of	of	IN
cord-002407-25cawzi0	249	31	influenza	influenza	NN
cord-002407-25cawzi0	249	32	vaccines	vaccine	NNS
cord-002407-25cawzi0	249	33	(	(	-LRB-
cord-002407-25cawzi0	249	34	Figure	figure	NN
cord-002407-25cawzi0	249	35	2	2	CD
cord-002407-25cawzi0	249	36	)	)	-RRB-
cord-002407-25cawzi0	249	37	[	[	-LRB-
cord-002407-25cawzi0	249	38	135	135	CD
cord-002407-25cawzi0	249	39	]	]	-RRB-
cord-002407-25cawzi0	249	40	.	.	.
cord-002407-25cawzi0	250	1	Moreover	moreover	RB
cord-002407-25cawzi0	250	2	,	,	,
cord-002407-25cawzi0	250	3	the	the	DT
cord-002407-25cawzi0	250	4	generation	generation	NN
cord-002407-25cawzi0	250	5	of	of	IN
cord-002407-25cawzi0	250	6	recombinant	recombinant	JJ
cord-002407-25cawzi0	250	7	influenza	influenza	NN
cord-002407-25cawzi0	250	8	viruses	virus	NNS
cord-002407-25cawzi0	250	9	using	use	VBG
cord-002407-25cawzi0	250	10	plasmid	plasmid	NN
cord-002407-25cawzi0	250	11	-	-	HYPH
cord-002407-25cawzi0	250	12	based	base	VBN
cord-002407-25cawzi0	250	13	reverse	reverse	JJ
cord-002407-25cawzi0	250	14	genetics	genetics	NN
cord-002407-25cawzi0	250	15	approaches	approach	NNS
cord-002407-25cawzi0	250	16	is	be	VBZ
cord-002407-25cawzi0	250	17	simple	simple	JJ
cord-002407-25cawzi0	250	18	,	,	,
cord-002407-25cawzi0	250	19	well	well	RB
cord-002407-25cawzi0	250	20	established	establish	VBN
cord-002407-25cawzi0	250	21	and	and	CC
cord-002407-25cawzi0	250	22	currently	currently	RB
cord-002407-25cawzi0	250	23	in	in	IN
cord-002407-25cawzi0	250	24	use	use	NN
cord-002407-25cawzi0	250	25	in	in	IN
cord-002407-25cawzi0	250	26	several	several	JJ
cord-002407-25cawzi0	250	27	laboratories	laboratory	NNS
cord-002407-25cawzi0	250	28	around	around	IN
cord-002407-25cawzi0	250	29	the	the	DT
cord-002407-25cawzi0	250	30	world	world	NN
cord-002407-25cawzi0	250	31	[	[	-LRB-
cord-002407-25cawzi0	250	32	139	139	CD
cord-002407-25cawzi0	250	33	,	,	,
cord-002407-25cawzi0	250	34	166	166	CD
cord-002407-25cawzi0	250	35	]	]	-RRB-
cord-002407-25cawzi0	251	1	(	(	-LRB-
cord-002407-25cawzi0	251	2	Figure	figure	NN
cord-002407-25cawzi0	251	3	4	4	CD
cord-002407-25cawzi0	251	4	)	)	-RRB-
cord-002407-25cawzi0	251	5	.	.	.
cord-002407-25cawzi0	252	1	Briefly	briefly	RB
cord-002407-25cawzi0	252	2	,	,	,
cord-002407-25cawzi0	252	3	the	the	DT
cord-002407-25cawzi0	252	4	eight	eight	CD
cord-002407-25cawzi0	252	5	-	-	HYPH
cord-002407-25cawzi0	252	6	ambisense	ambisense	NN
cord-002407-25cawzi0	252	7	plasmids	plasmid	NNS
cord-002407-25cawzi0	252	8	are	be	VBP
cord-002407-25cawzi0	252	9	co	co	JJ
cord-002407-25cawzi0	252	10	-	-	VBN
cord-002407-25cawzi0	252	11	transfected	transfecte	VBN
cord-002407-25cawzi0	253	1	into	into	IN
cord-002407-25cawzi0	253	2	susceptible	susceptible	JJ
cord-002407-25cawzi0	253	3	FDA	FDA	NNP
cord-002407-25cawzi0	253	4	-	-	HYPH
cord-002407-25cawzi0	253	5	approved	approve	VBN
cord-002407-25cawzi0	253	6	cells	cell	NNS
cord-002407-25cawzi0	253	7	,	,	,
cord-002407-25cawzi0	253	8	and	and	CC
cord-002407-25cawzi0	253	9	viable	viable	JJ
cord-002407-25cawzi0	253	10	virus	virus	NN
cord-002407-25cawzi0	253	11	can	can	MD
cord-002407-25cawzi0	253	12	be	be	VB
cord-002407-25cawzi0	253	13	recovered	recover	VBN
cord-002407-25cawzi0	253	14	from	from	IN
cord-002407-25cawzi0	253	15	the	the	DT
cord-002407-25cawzi0	253	16	tissue	tissue	NN
cord-002407-25cawzi0	253	17	culture	culture	NN
cord-002407-25cawzi0	253	18	supernatants	supernatant	NNS
cord-002407-25cawzi0	253	19	[	[	-LRB-
cord-002407-25cawzi0	253	20	139	139	CD
cord-002407-25cawzi0	253	21	,	,	,
cord-002407-25cawzi0	253	22	166	166	CD
cord-002407-25cawzi0	253	23	]	]	-RRB-
cord-002407-25cawzi0	253	24	,	,	,
cord-002407-25cawzi0	253	25	then	then	RB
cord-002407-25cawzi0	253	26	amplified	amplify	VBN
cord-002407-25cawzi0	253	27	in	in	IN
cord-002407-25cawzi0	253	28	either	either	DT
cord-002407-25cawzi0	253	29	embryonic	embryonic	JJ
cord-002407-25cawzi0	253	30	eggs	egg	NNS
cord-002407-25cawzi0	253	31	or	or	CC
cord-002407-25cawzi0	253	32	FDA	FDA	NNP
cord-002407-25cawzi0	253	33	-	-	HYPH
cord-002407-25cawzi0	253	34	approved	approve	VBN
cord-002407-25cawzi0	253	35	for	for	IN
cord-002407-25cawzi0	253	36	vaccine	vaccine	NN
cord-002407-25cawzi0	253	37	production	production	NN
cord-002407-25cawzi0	253	38	cells	cell	NNS
cord-002407-25cawzi0	253	39	(	(	-LRB-
cord-002407-25cawzi0	253	40	Figure	figure	NN
cord-002407-25cawzi0	253	41	4	4	CD
cord-002407-25cawzi0	253	42	)	)	-RRB-
cord-002407-25cawzi0	253	43	.	.	.
cord-002407-25cawzi0	253	44	 	 	_SP
cord-002407-25cawzi0	254	1	For	for	IN
cord-002407-25cawzi0	254	2	many	many	JJ
cord-002407-25cawzi0	254	3	years	year	NNS
cord-002407-25cawzi0	254	4	,	,	,
cord-002407-25cawzi0	254	5	IIVs	iiv	NNS
cord-002407-25cawzi0	254	6	have	have	VBP
cord-002407-25cawzi0	254	7	been	be	VBN
cord-002407-25cawzi0	254	8	produced	produce	VBN
cord-002407-25cawzi0	254	9	by	by	IN
cord-002407-25cawzi0	254	10	reassortment	reassortment	NN
cord-002407-25cawzi0	254	11	in	in	IN
cord-002407-25cawzi0	254	12	eggs	egg	NNS
cord-002407-25cawzi0	254	13	(	(	-LRB-
cord-002407-25cawzi0	254	14	Figure	figure	NN
cord-002407-25cawzi0	254	15	2	2	CD
cord-002407-25cawzi0	254	16	)	)	-RRB-
cord-002407-25cawzi0	254	17	[	[	-LRB-
cord-002407-25cawzi0	254	18	90	90	CD
cord-002407-25cawzi0	254	19	,	,	,
cord-002407-25cawzi0	254	20	98	98	CD
cord-002407-25cawzi0	254	21	,	,	,
cord-002407-25cawzi0	254	22	122	122	CD
cord-002407-25cawzi0	254	23	]	]	-RRB-
cord-002407-25cawzi0	254	24	.	.	.
cord-002407-25cawzi0	255	1	However	however	RB
cord-002407-25cawzi0	255	2	,	,	,
cord-002407-25cawzi0	255	3	strains	strain	NNS
cord-002407-25cawzi0	255	4	with	with	IN
cord-002407-25cawzi0	255	5	the	the	DT
cord-002407-25cawzi0	255	6	desired	desire	VBN
cord-002407-25cawzi0	255	7	genotype	genotype	NN
cord-002407-25cawzi0	255	8	(	(	-LRB-
cord-002407-25cawzi0	255	9	six	six	CD
cord-002407-25cawzi0	255	10	internal	internal	JJ
cord-002407-25cawzi0	255	11	genes	gene	NNS
cord-002407-25cawzi0	255	12	of	of	IN
cord-002407-25cawzi0	255	13	a	a	DT
cord-002407-25cawzi0	255	14	high	high	JJ
cord-002407-25cawzi0	255	15	-	-	HYPH
cord-002407-25cawzi0	255	16	growth	growth	NN
cord-002407-25cawzi0	255	17	virus	virus	NN
cord-002407-25cawzi0	255	18	and	and	CC
cord-002407-25cawzi0	255	19	the	the	DT
cord-002407-25cawzi0	255	20	HA	HA	NNP
cord-002407-25cawzi0	255	21	and	and	CC
cord-002407-25cawzi0	255	22	NA	NA	NNP
cord-002407-25cawzi0	255	23	glycoproteins	glycoprotein	NNS
cord-002407-25cawzi0	255	24	of	of	IN
cord-002407-25cawzi0	255	25	the	the	DT
cord-002407-25cawzi0	255	26	seasonal	seasonal	JJ
cord-002407-25cawzi0	255	27	influenza	influenza	NN
cord-002407-25cawzi0	255	28	virus	virus	NN
cord-002407-25cawzi0	255	29	)	)	-RRB-
cord-002407-25cawzi0	255	30	could	could	MD
cord-002407-25cawzi0	255	31	be	be	VB
cord-002407-25cawzi0	255	32	produced	produce	VBN
cord-002407-25cawzi0	255	33	easily	easily	RB
cord-002407-25cawzi0	255	34	and	and	CC
cord-002407-25cawzi0	255	35	more	more	RBR
cord-002407-25cawzi0	255	36	quickly	quickly	RB
cord-002407-25cawzi0	255	37	by	by	IN
cord-002407-25cawzi0	255	38	implementing	implement	VBG
cord-002407-25cawzi0	255	39	reverse	reverse	JJ
cord-002407-25cawzi0	255	40	genetics	genetics	NN
cord-002407-25cawzi0	255	41	approaches	approach	NNS
cord-002407-25cawzi0	255	42	.	.	.
cord-002407-25cawzi0	256	1	This	this	DT
cord-002407-25cawzi0	256	2	process	process	NN
cord-002407-25cawzi0	256	3	would	would	MD
cord-002407-25cawzi0	256	4	overcome	overcome	VB
cord-002407-25cawzi0	256	5	the	the	DT
cord-002407-25cawzi0	256	6	need	need	NN
cord-002407-25cawzi0	256	7	of	of	IN
cord-002407-25cawzi0	256	8	chicken	chicken	NN
cord-002407-25cawzi0	256	9	embryonated	embryonate	VBN
cord-002407-25cawzi0	256	10	eggs	egg	NNS
cord-002407-25cawzi0	256	11	to	to	TO
cord-002407-25cawzi0	256	12	generate	generate	VB
cord-002407-25cawzi0	256	13	the	the	DT
cord-002407-25cawzi0	256	14	desired	desire	VBN
cord-002407-25cawzi0	256	15	reassortant	reassortant	JJ
cord-002407-25cawzi0	256	16	virus	virus	NN
cord-002407-25cawzi0	256	17	and	and	CC
cord-002407-25cawzi0	256	18	,	,	,
cord-002407-25cawzi0	256	19	therefore	therefore	RB
cord-002407-25cawzi0	256	20	,	,	,
cord-002407-25cawzi0	256	21	minimizing	minimize	VBG
cord-002407-25cawzi0	256	22	the	the	DT
cord-002407-25cawzi0	256	23	time	time	NN
cord-002407-25cawzi0	256	24	associated	associate	VBN
cord-002407-25cawzi0	256	25	with	with	IN
cord-002407-25cawzi0	256	26	the	the	DT
cord-002407-25cawzi0	256	27	selection	selection	NN
cord-002407-25cawzi0	256	28	process	process	NN
cord-002407-25cawzi0	256	29	of	of	IN
cord-002407-25cawzi0	256	30	the	the	DT
cord-002407-25cawzi0	256	31	reassortant	reassortant	JJ
cord-002407-25cawzi0	256	32	IIV	IIV	NNP
cord-002407-25cawzi0	256	33	(	(	-LRB-
cord-002407-25cawzi0	256	34	Figure	figure	NN
cord-002407-25cawzi0	256	35	4A	4a	CD
cord-002407-25cawzi0	256	36	)	)	-RRB-
cord-002407-25cawzi0	256	37	.	.	.
cord-002407-25cawzi0	257	1	Moreover	moreover	RB
cord-002407-25cawzi0	257	2	,	,	,
cord-002407-25cawzi0	257	3	the	the	DT
cord-002407-25cawzi0	257	4	improvements	improvement	NNS
cord-002407-25cawzi0	257	5	in	in	IN
cord-002407-25cawzi0	257	6	surveillance	surveillance	NN
cord-002407-25cawzi0	257	7	,	,	,
cord-002407-25cawzi0	257	8	as	as	RB
cord-002407-25cawzi0	257	9	well	well	RB
cord-002407-25cawzi0	257	10	as	as	IN
cord-002407-25cawzi0	257	11	the	the	DT
cord-002407-25cawzi0	257	12	de	de	NNP
cord-002407-25cawzi0	257	13	novo	novo	NNP
cord-002407-25cawzi0	257	14	gene	gene	NN
cord-002407-25cawzi0	257	15	synthesis	synthesis	NN
cord-002407-25cawzi0	257	16	for	for	IN
cord-002407-25cawzi0	257	17	the	the	DT
cord-002407-25cawzi0	257	18	production	production	NN
cord-002407-25cawzi0	257	19	of	of	IN
cord-002407-25cawzi0	257	20	the	the	DT
cord-002407-25cawzi0	257	21	HA	HA	NNP
cord-002407-25cawzi0	257	22	and	and	CC
cord-002407-25cawzi0	257	23	NA	NA	NNP
cord-002407-25cawzi0	257	24	viral	viral	JJ
cord-002407-25cawzi0	257	25	segments	segment	NNS
cord-002407-25cawzi0	257	26	from	from	IN
cord-002407-25cawzi0	257	27	the	the	DT
cord-002407-25cawzi0	257	28	selected	select	VBN
cord-002407-25cawzi0	257	29	strains	strain	NNS
cord-002407-25cawzi0	257	30	could	could	MD
cord-002407-25cawzi0	257	31	reduce	reduce	VB
cord-002407-25cawzi0	257	32	considerably	considerably	RB
cord-002407-25cawzi0	257	33	the	the	DT
cord-002407-25cawzi0	257	34	time	time	NN
cord-002407-25cawzi0	257	35	of	of	IN
cord-002407-25cawzi0	257	36	vaccine	vaccine	NN
cord-002407-25cawzi0	257	37	production	production	NN
cord-002407-25cawzi0	257	38	.	.	.
cord-002407-25cawzi0	258	1	Although	although	IN
cord-002407-25cawzi0	258	2	influenza	influenza	NN
cord-002407-25cawzi0	258	3	reverse	reverse	JJ
cord-002407-25cawzi0	258	4	genetics	genetic	NNS
cord-002407-25cawzi0	258	5	could	could	MD
cord-002407-25cawzi0	258	6	be	be	VB
cord-002407-25cawzi0	258	7	useful	useful	JJ
cord-002407-25cawzi0	258	8	for	for	IN
cord-002407-25cawzi0	258	9	the	the	DT
cord-002407-25cawzi0	258	10	production	production	NN
cord-002407-25cawzi0	258	11	of	of	IN
cord-002407-25cawzi0	258	12	vaccine	vaccine	NN
cord-002407-25cawzi0	258	13	seed	seed	NN
cord-002407-25cawzi0	258	14	strains	strain	NNS
cord-002407-25cawzi0	258	15	,	,	,
cord-002407-25cawzi0	258	16	to	to	IN
cord-002407-25cawzi0	258	17	date	date	NN
cord-002407-25cawzi0	258	18	,	,	,
cord-002407-25cawzi0	258	19	it	-PRON-	PRP
cord-002407-25cawzi0	258	20	has	have	VBZ
cord-002407-25cawzi0	258	21	not	not	RB
cord-002407-25cawzi0	258	22	been	be	VBN
cord-002407-25cawzi0	258	23	possible	possible	JJ
cord-002407-25cawzi0	258	24	to	to	TO
cord-002407-25cawzi0	258	25	predict	predict	VB
cord-002407-25cawzi0	258	26	which	which	WDT
cord-002407-25cawzi0	258	27	gene	gene	NN
cord-002407-25cawzi0	258	28	segment(s	segment(s	NNP
cord-002407-25cawzi0	258	29	)	)	-RRB-
cord-002407-25cawzi0	258	30	constellations	constellation	NNS
cord-002407-25cawzi0	258	31	are	be	VBP
cord-002407-25cawzi0	258	32	required	require	VBN
cord-002407-25cawzi0	258	33	for	for	IN
cord-002407-25cawzi0	258	34	efficient	efficient	JJ
cord-002407-25cawzi0	258	35	growth	growth	NN
cord-002407-25cawzi0	258	36	of	of	IN
cord-002407-25cawzi0	258	37	different	different	JJ
cord-002407-25cawzi0	258	38	vaccine	vaccine	NN
cord-002407-25cawzi0	258	39	viruses	virus	NNS
cord-002407-25cawzi0	258	40	.	.	.
cord-002407-25cawzi0	259	1	Moreover	moreover	RB
cord-002407-25cawzi0	259	2	,	,	,
cord-002407-25cawzi0	259	3	the	the	DT
cord-002407-25cawzi0	259	4	time	time	NN
cord-002407-25cawzi0	259	5	to	to	TO
cord-002407-25cawzi0	259	6	produce	produce	VB
cord-002407-25cawzi0	259	7	vaccine	vaccine	NN
cord-002407-25cawzi0	259	8	viruses	virus	NNS
cord-002407-25cawzi0	259	9	using	use	VBG
cord-002407-25cawzi0	259	10	reverse	reverse	JJ
cord-002407-25cawzi0	259	11	genetics	genetic	NNS
cord-002407-25cawzi0	259	12	versus	versus	IN
cord-002407-25cawzi0	259	13	the	the	DT
cord-002407-25cawzi0	259	14	time	time	NN
cord-002407-25cawzi0	259	15	needed	need	VBD
cord-002407-25cawzi0	259	16	to	to	TO
cord-002407-25cawzi0	259	17	generate	generate	VB
cord-002407-25cawzi0	259	18	them	-PRON-	PRP
cord-002407-25cawzi0	259	19	using	use	VBG
cord-002407-25cawzi0	259	20	the	the	DT
cord-002407-25cawzi0	259	21	classical	classical	JJ
cord-002407-25cawzi0	259	22	reassortment	reassortment	NN
cord-002407-25cawzi0	259	23	approach	approach	NN
cord-002407-25cawzi0	259	24	could	could	MD
cord-002407-25cawzi0	259	25	be	be	VB
cord-002407-25cawzi0	259	26	a	a	DT
cord-002407-25cawzi0	259	27	major	major	JJ
cord-002407-25cawzi0	259	28	consideration	consideration	NN
cord-002407-25cawzi0	259	29	for	for	IN
cord-002407-25cawzi0	259	30	the	the	DT
cord-002407-25cawzi0	259	31	cost	cost	NN
cord-002407-25cawzi0	259	32	effectiveness	effectiveness	NN
cord-002407-25cawzi0	259	33	in	in	IN
cord-002407-25cawzi0	259	34	vaccine	vaccine	NN
cord-002407-25cawzi0	259	35	production	production	NN
cord-002407-25cawzi0	259	36	and	and	CC
cord-002407-25cawzi0	259	37	manufacturing	manufacturing	NN
cord-002407-25cawzi0	259	38	.	.	.
cord-002407-25cawzi0	260	1	Thus	thus	RB
cord-002407-25cawzi0	260	2	,	,	,
cord-002407-25cawzi0	260	3	the	the	DT
cord-002407-25cawzi0	260	4	traditional	traditional	JJ
cord-002407-25cawzi0	260	5	viral	viral	JJ
cord-002407-25cawzi0	260	6	reassortment	reassortment	NN
cord-002407-25cawzi0	260	7	has	have	VBZ
cord-002407-25cawzi0	260	8	remained	remain	VBN
cord-002407-25cawzi0	260	9	preferred	preferred	JJ
cord-002407-25cawzi0	260	10	because	because	IN
cord-002407-25cawzi0	260	11	it	-PRON-	PRP
cord-002407-25cawzi0	260	12	allows	allow	VBZ
cord-002407-25cawzi0	260	13	the	the	DT
cord-002407-25cawzi0	260	14	generation	generation	NN
cord-002407-25cawzi0	260	15	of	of	IN
cord-002407-25cawzi0	260	16	a	a	DT
cord-002407-25cawzi0	260	17	number	number	NN
cord-002407-25cawzi0	260	18	of	of	IN
cord-002407-25cawzi0	260	19	diverse	diverse	JJ
cord-002407-25cawzi0	260	20	gene(s	gene(s	NNP
cord-002407-25cawzi0	260	21	)	)	-RRB-
cord-002407-25cawzi0	260	22	combinations	combination	NNS
cord-002407-25cawzi0	260	23	in	in	IN
cord-002407-25cawzi0	260	24	order	order	NN
cord-002407-25cawzi0	260	25	to	to	TO
cord-002407-25cawzi0	260	26	select	select	VB
cord-002407-25cawzi0	260	27	recombinant	recombinant	JJ
cord-002407-25cawzi0	260	28	viruses	virus	NNS
cord-002407-25cawzi0	260	29	with	with	IN
cord-002407-25cawzi0	260	30	better	well	JJR
cord-002407-25cawzi0	260	31	fitness	fitness	NN
cord-002407-25cawzi0	260	32	[	[	-LRB-
cord-002407-25cawzi0	260	33	98	98	CD
cord-002407-25cawzi0	260	34	]	]	-RRB-
cord-002407-25cawzi0	260	35	.	.	.
cord-002407-25cawzi0	261	1	During	during	IN
cord-002407-25cawzi0	261	2	the	the	DT
cord-002407-25cawzi0	261	3	last	last	JJ
cord-002407-25cawzi0	261	4	few	few	JJ
cord-002407-25cawzi0	261	5	decades	decade	NNS
cord-002407-25cawzi0	261	6	,	,	,
cord-002407-25cawzi0	261	7	considerable	considerable	JJ
cord-002407-25cawzi0	261	8	improvements	improvement	NNS
cord-002407-25cawzi0	261	9	have	have	VBP
cord-002407-25cawzi0	261	10	been	be	VBN
cord-002407-25cawzi0	261	11	accomplished	accomplish	VBN
cord-002407-25cawzi0	261	12	in	in	IN
cord-002407-25cawzi0	261	13	the	the	DT
cord-002407-25cawzi0	261	14	development	development	NN
cord-002407-25cawzi0	261	15	of	of	IN
cord-002407-25cawzi0	261	16	influenza	influenza	NN
cord-002407-25cawzi0	261	17	vaccines	vaccine	NNS
cord-002407-25cawzi0	261	18	.	.	.
cord-002407-25cawzi0	262	1	However	however	RB
cord-002407-25cawzi0	262	2	,	,	,
cord-002407-25cawzi0	262	3	novel	novel	NN
cord-002407-25cawzi0	262	4	approaches	approach	NNS
cord-002407-25cawzi0	262	5	to	to	TO
cord-002407-25cawzi0	262	6	increase	increase	VB
cord-002407-25cawzi0	262	7	the	the	DT
cord-002407-25cawzi0	262	8	effectiveness	effectiveness	NN
cord-002407-25cawzi0	262	9	of	of	IN
cord-002407-25cawzi0	262	10	seasonal	seasonal	JJ
cord-002407-25cawzi0	262	11	influenza	influenza	NN
cord-002407-25cawzi0	262	12	vaccines	vaccine	NNS
cord-002407-25cawzi0	262	13	are	be	VBP
cord-002407-25cawzi0	262	14	needed	need	VBN
cord-002407-25cawzi0	262	15	.	.	.
cord-002407-25cawzi0	263	1	Reverse	reverse	VB
cord-002407-25cawzi0	263	2	genetics	genetics	NN
cord-002407-25cawzi0	263	3	technologies	technology	NNS
cord-002407-25cawzi0	263	4	have	have	VBP
cord-002407-25cawzi0	263	5	proven	prove	VBN
cord-002407-25cawzi0	263	6	a	a	DT
cord-002407-25cawzi0	263	7	valuable	valuable	JJ
cord-002407-25cawzi0	263	8	tool	tool	NN
cord-002407-25cawzi0	263	9	to	to	TO
cord-002407-25cawzi0	263	10	develop	develop	VB
cord-002407-25cawzi0	263	11	reassortant	reassortant	JJ
cord-002407-25cawzi0	263	12	strains	strain	NNS
cord-002407-25cawzi0	263	13	for	for	IN
cord-002407-25cawzi0	263	14	the	the	DT
cord-002407-25cawzi0	263	15	production	production	NN
cord-002407-25cawzi0	263	16	of	of	IN
cord-002407-25cawzi0	263	17	LAIV	LAIV	NNP
cord-002407-25cawzi0	263	18	candidates	candidate	NNS
cord-002407-25cawzi0	263	19	(	(	-LRB-
cord-002407-25cawzi0	263	20	Figure	figure	NN
cord-002407-25cawzi0	263	21	4B	4b	CD
cord-002407-25cawzi0	263	22	)	)	-RRB-
cord-002407-25cawzi0	263	23	.	.	.
cord-002407-25cawzi0	264	1	Currently	currently	RB
cord-002407-25cawzi0	264	2	,	,	,
cord-002407-25cawzi0	264	3	seed	seed	NN
cord-002407-25cawzi0	264	4	viruses	virus	NNS
cord-002407-25cawzi0	264	5	containing	contain	VBG
cord-002407-25cawzi0	264	6	six	six	CD
cord-002407-25cawzi0	264	7	gene	gene	NN
cord-002407-25cawzi0	264	8	segments	segment	NNS
cord-002407-25cawzi0	264	9	from	from	IN
cord-002407-25cawzi0	264	10	the	the	DT
cord-002407-25cawzi0	264	11	MDV	MDV	NNP
cord-002407-25cawzi0	264	12	A	A	NNP
cord-002407-25cawzi0	264	13	/	/	SYM
cord-002407-25cawzi0	264	14	Ann	Ann	NNP
cord-002407-25cawzi0	264	15	Arbor/6/60	Arbor/6/60	NNP
cord-002407-25cawzi0	264	16	(	(	-LRB-
cord-002407-25cawzi0	264	17	H2N2	H2N2	NNP
cord-002407-25cawzi0	264	18	)	)	-RRB-
cord-002407-25cawzi0	264	19	and	and	CC
cord-002407-25cawzi0	264	20	the	the	DT
cord-002407-25cawzi0	264	21	HA	HA	NNP
cord-002407-25cawzi0	264	22	and	and	CC
cord-002407-25cawzi0	264	23	NA	NA	NNP
cord-002407-25cawzi0	264	24	from	from	IN
cord-002407-25cawzi0	264	25	the	the	DT
cord-002407-25cawzi0	264	26	selected	select	VBN
cord-002407-25cawzi0	264	27	seasonal	seasonal	JJ
cord-002407-25cawzi0	264	28	virus	virus	NN
cord-002407-25cawzi0	264	29	can	can	MD
cord-002407-25cawzi0	264	30	be	be	VB
cord-002407-25cawzi0	264	31	quickly	quickly	RB
cord-002407-25cawzi0	264	32	generated	generate	VBN
cord-002407-25cawzi0	264	33	using	use	VBG
cord-002407-25cawzi0	264	34	reverse	reverse	JJ
cord-002407-25cawzi0	264	35	genetics	genetics	NN
cord-002407-25cawzi0	264	36	systems	system	NNS
cord-002407-25cawzi0	264	37	[	[	-LRB-
cord-002407-25cawzi0	264	38	98	98	CD
cord-002407-25cawzi0	264	39	,	,	,
cord-002407-25cawzi0	264	40	131	131	CD
cord-002407-25cawzi0	264	41	]	]	-RRB-
cord-002407-25cawzi0	265	1	(	(	-LRB-
cord-002407-25cawzi0	265	2	Figure	figure	NN
cord-002407-25cawzi0	265	3	4B	4b	CD
cord-002407-25cawzi0	265	4	)	)	-RRB-
cord-002407-25cawzi0	265	5	.	.	.
cord-002407-25cawzi0	266	1	The	the	DT
cord-002407-25cawzi0	266	2	HA	HA	NNP
cord-002407-25cawzi0	266	3	and	and	CC
cord-002407-25cawzi0	266	4	NA	NA	NNP
cord-002407-25cawzi0	266	5	from	from	IN
cord-002407-25cawzi0	266	6	selected	select	VBN
cord-002407-25cawzi0	266	7	seasonal	seasonal	JJ
cord-002407-25cawzi0	266	8	influenza	influenza	NN
cord-002407-25cawzi0	266	9	viruses	virus	NNS
cord-002407-25cawzi0	266	10	can	can	MD
cord-002407-25cawzi0	266	11	be	be	VB
cord-002407-25cawzi0	266	12	amplified	amplify	VBN
cord-002407-25cawzi0	266	13	by	by	IN
cord-002407-25cawzi0	266	14	RT	RT	NNP
cord-002407-25cawzi0	266	15	-	-	HYPH
cord-002407-25cawzi0	266	16	PCR	PCR	NNP
cord-002407-25cawzi0	266	17	or	or	CC
cord-002407-25cawzi0	266	18	quickly	quickly	RB
cord-002407-25cawzi0	266	19	chemically	chemically	RB
cord-002407-25cawzi0	266	20	synthetized	synthetize	VBN
cord-002407-25cawzi0	266	21	and	and	CC
cord-002407-25cawzi0	266	22	then	then	RB
cord-002407-25cawzi0	266	23	cloned	clone	VBN
cord-002407-25cawzi0	266	24	in	in	IN
cord-002407-25cawzi0	266	25	ambisense	ambisense	NN
cord-002407-25cawzi0	266	26	plasmids	plasmid	NNS
cord-002407-25cawzi0	266	27	used	use	VBN
cord-002407-25cawzi0	266	28	for	for	IN
cord-002407-25cawzi0	266	29	virus	virus	NN
cord-002407-25cawzi0	266	30	rescue	rescue	NN
cord-002407-25cawzi0	266	31	.	.	.
cord-002407-25cawzi0	267	1	This	this	DT
cord-002407-25cawzi0	267	2	technology	technology	NN
cord-002407-25cawzi0	267	3	could	could	MD
cord-002407-25cawzi0	267	4	speed	speed	VB
cord-002407-25cawzi0	267	5	up	up	RP
cord-002407-25cawzi0	267	6	the	the	DT
cord-002407-25cawzi0	267	7	development	development	NN
cord-002407-25cawzi0	267	8	of	of	IN
cord-002407-25cawzi0	267	9	new	new	JJ
cord-002407-25cawzi0	267	10	LAIVs	laiv	NNS
cord-002407-25cawzi0	267	11	,	,	,
cord-002407-25cawzi0	267	12	bypassing	bypass	VBG
cord-002407-25cawzi0	267	13	the	the	DT
cord-002407-25cawzi0	267	14	need	need	NN
cord-002407-25cawzi0	267	15	to	to	TO
cord-002407-25cawzi0	267	16	isolate	isolate	VB
cord-002407-25cawzi0	267	17	the	the	DT
cord-002407-25cawzi0	267	18	exact	exact	JJ
cord-002407-25cawzi0	267	19	virus	virus	NN
cord-002407-25cawzi0	267	20	reassortment	reassortment	NN
cord-002407-25cawzi0	267	21	in	in	IN
cord-002407-25cawzi0	267	22	eggs	egg	NNS
cord-002407-25cawzi0	267	23	(	(	-LRB-
cord-002407-25cawzi0	267	24	Figure	figure	NN
cord-002407-25cawzi0	267	25	2	2	CD
cord-002407-25cawzi0	267	26	)	)	-RRB-
cord-002407-25cawzi0	267	27	.	.	.
cord-002407-25cawzi0	268	1	The	the	DT
cord-002407-25cawzi0	268	2	best	good	JJS
cord-002407-25cawzi0	268	3	way	way	NN
cord-002407-25cawzi0	268	4	to	to	TO
cord-002407-25cawzi0	268	5	combat	combat	VB
cord-002407-25cawzi0	268	6	influenza	influenza	NN
cord-002407-25cawzi0	268	7	virus	virus	NN
cord-002407-25cawzi0	268	8	infection	infection	NN
cord-002407-25cawzi0	268	9	is	be	VBZ
cord-002407-25cawzi0	268	10	to	to	TO
cord-002407-25cawzi0	268	11	prevent	prevent	VB
cord-002407-25cawzi0	268	12	it	-PRON-	PRP
cord-002407-25cawzi0	268	13	.	.	.
cord-002407-25cawzi0	269	1	Thus	thus	RB
cord-002407-25cawzi0	269	2	,	,	,
cord-002407-25cawzi0	269	3	an	an	DT
cord-002407-25cawzi0	269	4	urgent	urgent	JJ
cord-002407-25cawzi0	269	5	need	need	NN
cord-002407-25cawzi0	269	6	exists	exist	VBZ
cord-002407-25cawzi0	269	7	to	to	TO
cord-002407-25cawzi0	269	8	develop	develop	VB
cord-002407-25cawzi0	269	9	novel	novel	JJ
cord-002407-25cawzi0	269	10	and	and	CC
cord-002407-25cawzi0	269	11	more	more	RBR
cord-002407-25cawzi0	269	12	effective	effective	JJ
cord-002407-25cawzi0	269	13	influenza	influenza	NN
cord-002407-25cawzi0	269	14	vaccines	vaccine	NNS
cord-002407-25cawzi0	269	15	.	.	.
cord-002407-25cawzi0	270	1	Plasmid	plasmid	NN
cord-002407-25cawzi0	270	2	-	-	HYPH
cord-002407-25cawzi0	270	3	based	base	VBN
cord-002407-25cawzi0	270	4	reverse	reverse	JJ
cord-002407-25cawzi0	270	5	genetic	genetic	JJ
cord-002407-25cawzi0	270	6	technologies	technology	NNS
cord-002407-25cawzi0	270	7	have	have	VBP
cord-002407-25cawzi0	270	8	allowed	allow	VBN
cord-002407-25cawzi0	270	9	the	the	DT
cord-002407-25cawzi0	270	10	engineering	engineering	NN
cord-002407-25cawzi0	270	11	of	of	IN
cord-002407-25cawzi0	270	12	recombinant	recombinant	JJ
cord-002407-25cawzi0	270	13	influenza	influenza	NN
cord-002407-25cawzi0	270	14	viruses	virus	NNS
cord-002407-25cawzi0	270	15	that	that	WDT
cord-002407-25cawzi0	270	16	contain	contain	VBP
cord-002407-25cawzi0	270	17	single	single	JJ
cord-002407-25cawzi0	270	18	or	or	CC
cord-002407-25cawzi0	270	19	multiple	multiple	JJ
cord-002407-25cawzi0	270	20	mutations	mutation	NNS
cord-002407-25cawzi0	270	21	in	in	IN
cord-002407-25cawzi0	270	22	the	the	DT
cord-002407-25cawzi0	270	23	viral	viral	JJ
cord-002407-25cawzi0	270	24	genome	genome	NN
cord-002407-25cawzi0	270	25	,	,	,
cord-002407-25cawzi0	270	26	which	which	WDT
cord-002407-25cawzi0	270	27	can	can	MD
cord-002407-25cawzi0	270	28	be	be	VB
cord-002407-25cawzi0	270	29	potentially	potentially	RB
cord-002407-25cawzi0	270	30	implemented	implement	VBN
cord-002407-25cawzi0	270	31	as	as	IN
cord-002407-25cawzi0	270	32	novel	novel	JJ
cord-002407-25cawzi0	270	33	or	or	CC
cord-002407-25cawzi0	270	34	improved	improved	JJ
cord-002407-25cawzi0	270	35	vaccine	vaccine	NN
cord-002407-25cawzi0	270	36	approaches	approach	NNS
cord-002407-25cawzi0	270	37	.	.	.
cord-002407-25cawzi0	271	1	In	in	IN
cord-002407-25cawzi0	271	2	fact	fact	NN
cord-002407-25cawzi0	271	3	,	,	,
cord-002407-25cawzi0	271	4	several	several	JJ
cord-002407-25cawzi0	271	5	novel	novel	JJ
cord-002407-25cawzi0	271	6	vaccine	vaccine	NN
cord-002407-25cawzi0	271	7	candidates	candidate	NNS
cord-002407-25cawzi0	271	8	have	have	VBP
cord-002407-25cawzi0	271	9	been	be	VBN
cord-002407-25cawzi0	271	10	developed	develop	VBN
cord-002407-25cawzi0	271	11	with	with	IN
cord-002407-25cawzi0	271	12	promising	promising	JJ
cord-002407-25cawzi0	271	13	results	result	NNS
cord-002407-25cawzi0	271	14	in	in	IN
cord-002407-25cawzi0	271	15	animal	animal	NN
cord-002407-25cawzi0	271	16	models	model	NNS
cord-002407-25cawzi0	271	17	of	of	IN
cord-002407-25cawzi0	271	18	experimentation	experimentation	NN
cord-002407-25cawzi0	271	19	.	.	.
cord-002407-25cawzi0	272	1	Here	here	RB
cord-002407-25cawzi0	272	2	,	,	,
cord-002407-25cawzi0	272	3	we	-PRON-	PRP
cord-002407-25cawzi0	272	4	review	review	VBP
cord-002407-25cawzi0	272	5	and	and	CC
cord-002407-25cawzi0	272	6	discuss	discuss	VBP
cord-002407-25cawzi0	272	7	some	some	DT
cord-002407-25cawzi0	272	8	of	of	IN
cord-002407-25cawzi0	272	9	them	-PRON-	PRP
cord-002407-25cawzi0	272	10	.	.	.
cord-002407-25cawzi0	273	1	Because	because	IN
cord-002407-25cawzi0	273	2	of	of	IN
cord-002407-25cawzi0	273	3	NS1	ns1	NN
cord-002407-25cawzi0	273	4	's	's	POS
cord-002407-25cawzi0	273	5	ability	ability	NN
cord-002407-25cawzi0	273	6	to	to	TO
cord-002407-25cawzi0	273	7	hijack	hijack	VB
cord-002407-25cawzi0	273	8	the	the	DT
cord-002407-25cawzi0	273	9	host	host	NN
cord-002407-25cawzi0	273	10	innate	innate	JJ
cord-002407-25cawzi0	273	11	immune	immune	JJ
cord-002407-25cawzi0	273	12	IFN	IFN	NNP
cord-002407-25cawzi0	273	13	-	-	HYPH
cord-002407-25cawzi0	273	14	I	I	NNP
cord-002407-25cawzi0	273	15	response	response	NN
cord-002407-25cawzi0	273	16	,	,	,
cord-002407-25cawzi0	273	17	a	a	DT
cord-002407-25cawzi0	273	18	variety	variety	NN
cord-002407-25cawzi0	273	19	of	of	IN
cord-002407-25cawzi0	273	20	potential	potential	JJ
cord-002407-25cawzi0	273	21	vaccine	vaccine	NN
cord-002407-25cawzi0	273	22	strategies	strategy	NNS
cord-002407-25cawzi0	273	23	have	have	VBP
cord-002407-25cawzi0	273	24	been	be	VBN
cord-002407-25cawzi0	273	25	developed	develop	VBN
cord-002407-25cawzi0	273	26	,	,	,
cord-002407-25cawzi0	273	27	which	which	WDT
cord-002407-25cawzi0	273	28	are	be	VBP
cord-002407-25cawzi0	273	29	based	base	VBN
cord-002407-25cawzi0	273	30	on	on	IN
cord-002407-25cawzi0	273	31	the	the	DT
cord-002407-25cawzi0	273	32	use	use	NN
cord-002407-25cawzi0	273	33	of	of	IN
cord-002407-25cawzi0	273	34	modified	modify	VBN
cord-002407-25cawzi0	273	35	NS1	ns1	NN
cord-002407-25cawzi0	273	36	proteins	protein	NNS
cord-002407-25cawzi0	273	37	as	as	IN
cord-002407-25cawzi0	273	38	a	a	DT
cord-002407-25cawzi0	273	39	means	means	NN
cord-002407-25cawzi0	273	40	for	for	IN
cord-002407-25cawzi0	273	41	virus	virus	NN
cord-002407-25cawzi0	273	42	attenuation	attenuation	NN
cord-002407-25cawzi0	273	43	[	[	-LRB-
cord-002407-25cawzi0	273	44	167	167	CD
cord-002407-25cawzi0	273	45	]	]	-RRB-
cord-002407-25cawzi0	274	1	[	[	-LRB-
cord-002407-25cawzi0	274	2	168	168	CD
cord-002407-25cawzi0	274	3	]	]	-RRB-
cord-002407-25cawzi0	274	4	[	[	-LRB-
cord-002407-25cawzi0	274	5	169	169	CD
cord-002407-25cawzi0	274	6	]	]	-RRB-
cord-002407-25cawzi0	275	1	[	[	-LRB-
cord-002407-25cawzi0	275	2	170	170	CD
cord-002407-25cawzi0	275	3	]	]	-RRB-
cord-002407-25cawzi0	275	4	[	[	-LRB-
cord-002407-25cawzi0	275	5	171	171	CD
cord-002407-25cawzi0	275	6	]	]	-RRB-
cord-002407-25cawzi0	275	7	[	[	-LRB-
cord-002407-25cawzi0	275	8	172	172	CD
cord-002407-25cawzi0	275	9	]	]	-RRB-
cord-002407-25cawzi0	275	10	.	.	.
cord-002407-25cawzi0	276	1	Equine	equine	JJ
cord-002407-25cawzi0	276	2	[	[	-LRB-
cord-002407-25cawzi0	276	3	170	170	CD
cord-002407-25cawzi0	276	4	]	]	-RRB-
cord-002407-25cawzi0	276	5	,	,	,
cord-002407-25cawzi0	276	6	swine	swine	NN
cord-002407-25cawzi0	276	7	[	[	-LRB-
cord-002407-25cawzi0	276	8	169	169	CD
cord-002407-25cawzi0	276	9	,	,	,
cord-002407-25cawzi0	276	10	173	173	CD
cord-002407-25cawzi0	276	11	,	,	,
cord-002407-25cawzi0	276	12	174	174	CD
cord-002407-25cawzi0	276	13	]	]	-RRB-
cord-002407-25cawzi0	276	14	,	,	,
cord-002407-25cawzi0	276	15	avian	avian	JJ
cord-002407-25cawzi0	276	16	[	[	-LRB-
cord-002407-25cawzi0	276	17	167	167	CD
cord-002407-25cawzi0	276	18	,	,	,
cord-002407-25cawzi0	276	19	175	175	CD
cord-002407-25cawzi0	276	20	,	,	,
cord-002407-25cawzi0	276	21	176	176	CD
cord-002407-25cawzi0	276	22	]	]	-RRB-
cord-002407-25cawzi0	276	23	,	,	,
cord-002407-25cawzi0	276	24	canine	canine	JJ
cord-002407-25cawzi0	276	25	[	[	-LRB-
cord-002407-25cawzi0	276	26	177	177	CD
cord-002407-25cawzi0	276	27	]	]	-RRB-
cord-002407-25cawzi0	276	28	and	and	CC
cord-002407-25cawzi0	276	29	human	human	JJ
cord-002407-25cawzi0	276	30	[	[	-LRB-
cord-002407-25cawzi0	276	31	178	178	CD
cord-002407-25cawzi0	276	32	,	,	,
cord-002407-25cawzi0	276	33	179	179	CD
cord-002407-25cawzi0	276	34	]	]	-RRB-
cord-002407-25cawzi0	276	35	IAVs	iav	NNS
cord-002407-25cawzi0	276	36	with	with	IN
cord-002407-25cawzi0	276	37	partial	partial	JJ
cord-002407-25cawzi0	276	38	truncations	truncation	NNS
cord-002407-25cawzi0	276	39	in	in	IN
cord-002407-25cawzi0	276	40	or	or	CC
cord-002407-25cawzi0	276	41	deletions	deletion	NNS
cord-002407-25cawzi0	276	42	of	of	IN
cord-002407-25cawzi0	276	43	the	the	DT
cord-002407-25cawzi0	276	44	viral	viral	JJ
cord-002407-25cawzi0	276	45	NS1	ns1	NN
cord-002407-25cawzi0	276	46	protein	protein	NN
cord-002407-25cawzi0	276	47	are	be	VBP
cord-002407-25cawzi0	276	48	all	all	DT
cord-002407-25cawzi0	276	49	attenuated	attenuate	VBN
cord-002407-25cawzi0	276	50	in	in	IN
cord-002407-25cawzi0	276	51	vitro	vitro	FW
cord-002407-25cawzi0	276	52	and	and	CC
cord-002407-25cawzi0	276	53	in	in	IN
cord-002407-25cawzi0	276	54	vivo	vivo	NNP
cord-002407-25cawzi0	276	55	[	[	-LRB-
cord-002407-25cawzi0	276	56	167	167	CD
cord-002407-25cawzi0	276	57	,	,	,
cord-002407-25cawzi0	276	58	169	169	CD
cord-002407-25cawzi0	276	59	,	,	,
cord-002407-25cawzi0	276	60	170	170	CD
cord-002407-25cawzi0	276	61	,	,	,
cord-002407-25cawzi0	276	62	179	179	CD
cord-002407-25cawzi0	276	63	]	]	-RRB-
cord-002407-25cawzi0	276	64	.	.	.
cord-002407-25cawzi0	277	1	Importantly	importantly	RB
cord-002407-25cawzi0	277	2	,	,	,
cord-002407-25cawzi0	277	3	these	these	DT
cord-002407-25cawzi0	277	4	recombinant	recombinant	JJ
cord-002407-25cawzi0	277	5	IAVs	iav	NNS
cord-002407-25cawzi0	277	6	can	can	MD
cord-002407-25cawzi0	277	7	induce	induce	VB
cord-002407-25cawzi0	277	8	a	a	DT
cord-002407-25cawzi0	277	9	protective	protective	JJ
cord-002407-25cawzi0	277	10	immune	immune	JJ
cord-002407-25cawzi0	277	11	response	response	NN
cord-002407-25cawzi0	277	12	upon	upon	IN
cord-002407-25cawzi0	277	13	a	a	DT
cord-002407-25cawzi0	277	14	single	single	JJ
cord-002407-25cawzi0	277	15	intranasal	intranasal	NN
cord-002407-25cawzi0	277	16	vaccination	vaccination	NN
cord-002407-25cawzi0	277	17	in	in	IN
cord-002407-25cawzi0	277	18	mice	mouse	NNS
cord-002407-25cawzi0	277	19	[	[	-LRB-
cord-002407-25cawzi0	277	20	177	177	CD
cord-002407-25cawzi0	277	21	,	,	,
cord-002407-25cawzi0	277	22	[	[	-LRB-
cord-002407-25cawzi0	277	23	179	179	CD
cord-002407-25cawzi0	277	24	]	]	-RRB-
cord-002407-25cawzi0	278	1	[	[	-LRB-
cord-002407-25cawzi0	278	2	180	180	CD
cord-002407-25cawzi0	278	3	]	]	-RRB-
cord-002407-25cawzi0	278	4	[	[	-LRB-
cord-002407-25cawzi0	278	5	181	181	CD
cord-002407-25cawzi0	278	6	]	]	-RRB-
cord-002407-25cawzi0	278	7	,	,	,
cord-002407-25cawzi0	278	8	horses	horse	NNS
cord-002407-25cawzi0	278	9	[	[	-LRB-
cord-002407-25cawzi0	278	10	170	170	CD
cord-002407-25cawzi0	278	11	]	]	-RRB-
cord-002407-25cawzi0	278	12	,	,	,
cord-002407-25cawzi0	278	13	pigs	pig	NNS
cord-002407-25cawzi0	278	14	[	[	-LRB-
cord-002407-25cawzi0	278	15	169	169	CD
cord-002407-25cawzi0	278	16	,	,	,
cord-002407-25cawzi0	278	17	173	173	CD
cord-002407-25cawzi0	278	18	,	,	,
cord-002407-25cawzi0	278	19	174	174	CD
cord-002407-25cawzi0	278	20	]	]	-RRB-
cord-002407-25cawzi0	278	21	,	,	,
cord-002407-25cawzi0	278	22	birds	bird	NNS
cord-002407-25cawzi0	278	23	[	[	-LRB-
cord-002407-25cawzi0	278	24	167	167	CD
cord-002407-25cawzi0	278	25	,	,	,
cord-002407-25cawzi0	278	26	175	175	CD
cord-002407-25cawzi0	278	27	,	,	,
cord-002407-25cawzi0	278	28	176	176	CD
cord-002407-25cawzi0	278	29	]	]	-RRB-
cord-002407-25cawzi0	278	30	and	and	CC
cord-002407-25cawzi0	278	31	macaques	macaque	NNS
cord-002407-25cawzi0	278	32	[	[	-LRB-
cord-002407-25cawzi0	278	33	178	178	CD
cord-002407-25cawzi0	278	34	]	]	-RRB-
cord-002407-25cawzi0	279	1	;	;	:
cord-002407-25cawzi0	279	2	therefore	therefore	RB
cord-002407-25cawzi0	279	3	,	,	,
cord-002407-25cawzi0	279	4	they	-PRON-	PRP
cord-002407-25cawzi0	279	5	represent	represent	VBP
cord-002407-25cawzi0	279	6	excellent	excellent	JJ
cord-002407-25cawzi0	279	7	LAIV	LAIV	NNP
cord-002407-25cawzi0	279	8	candidates	candidate	NNS
cord-002407-25cawzi0	279	9	to	to	TO
cord-002407-25cawzi0	279	10	prevent	prevent	VB
cord-002407-25cawzi0	279	11	IAV	IAV	NNP
cord-002407-25cawzi0	279	12	infections	infection	NNS
cord-002407-25cawzi0	279	13	.	.	.
cord-002407-25cawzi0	280	1	In	in	IN
cord-002407-25cawzi0	280	2	addition	addition	NN
cord-002407-25cawzi0	280	3	,	,	,
cord-002407-25cawzi0	280	4	a	a	DT
cord-002407-25cawzi0	280	5	similar	similar	JJ
cord-002407-25cawzi0	280	6	approach	approach	NN
cord-002407-25cawzi0	280	7	has	have	VBZ
cord-002407-25cawzi0	280	8	been	be	VBN
cord-002407-25cawzi0	280	9	employed	employ	VBN
cord-002407-25cawzi0	280	10	to	to	TO
cord-002407-25cawzi0	280	11	develop	develop	VB
cord-002407-25cawzi0	280	12	attenuated	attenuated	JJ
cord-002407-25cawzi0	280	13	IBVs	ibv	NNS
cord-002407-25cawzi0	280	14	with	with	IN
cord-002407-25cawzi0	280	15	similar	similar	JJ
cord-002407-25cawzi0	280	16	results	result	NNS
cord-002407-25cawzi0	280	17	[	[	-LRB-
cord-002407-25cawzi0	280	18	180	180	CD
cord-002407-25cawzi0	280	19	]	]	-RRB-
cord-002407-25cawzi0	280	20	.	.	.
cord-002407-25cawzi0	281	1	Mice	mouse	NNS
cord-002407-25cawzi0	281	2	inoculated	inoculate	VBN
cord-002407-25cawzi0	281	3	with	with	IN
cord-002407-25cawzi0	281	4	the	the	DT
cord-002407-25cawzi0	281	5	NS1-truncated	ns1-truncated	JJ
cord-002407-25cawzi0	281	6	or	or	CC
cord-002407-25cawzi0	281	7	-deleted	-deleted	JJ
cord-002407-25cawzi0	281	8	mutants	mutant	NNS
cord-002407-25cawzi0	281	9	elicited	elicit	VBD
cord-002407-25cawzi0	281	10	an	an	DT
cord-002407-25cawzi0	281	11	antibody	antibody	NN
cord-002407-25cawzi0	281	12	response	response	NN
cord-002407-25cawzi0	281	13	and	and	CC
cord-002407-25cawzi0	281	14	showed	show	VBD
cord-002407-25cawzi0	281	15	protection	protection	NN
cord-002407-25cawzi0	281	16	against	against	IN
cord-002407-25cawzi0	281	17	WT	WT	NNP
cord-002407-25cawzi0	281	18	virus	virus	NN
cord-002407-25cawzi0	281	19	challenge	challenge	NN
cord-002407-25cawzi0	281	20	[	[	-LRB-
cord-002407-25cawzi0	281	21	180	180	CD
cord-002407-25cawzi0	281	22	]	]	-RRB-
cord-002407-25cawzi0	281	23	.	.	.
cord-002407-25cawzi0	282	1	Thus	thus	RB
cord-002407-25cawzi0	282	2	,	,	,
cord-002407-25cawzi0	282	3	these	these	DT
cord-002407-25cawzi0	282	4	NS1-truncated	ns1-truncate	VBN
cord-002407-25cawzi0	282	5	influenza	influenza	NN
cord-002407-25cawzi0	282	6	A	a	NN
cord-002407-25cawzi0	282	7	and	and	CC
cord-002407-25cawzi0	282	8	B	b	NN
cord-002407-25cawzi0	282	9	viruses	virus	NNS
cord-002407-25cawzi0	282	10	represent	represent	VBP
cord-002407-25cawzi0	282	11	excellent	excellent	JJ
cord-002407-25cawzi0	282	12	candidates	candidate	NNS
cord-002407-25cawzi0	282	13	as	as	IN
cord-002407-25cawzi0	282	14	safe	safe	JJ
cord-002407-25cawzi0	282	15	,	,	,
cord-002407-25cawzi0	282	16	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	282	17	and	and	CC
cord-002407-25cawzi0	282	18	protective	protective	JJ
cord-002407-25cawzi0	282	19	LAIVs	laiv	NNS
cord-002407-25cawzi0	282	20	for	for	IN
cord-002407-25cawzi0	282	21	multiple	multiple	JJ
cord-002407-25cawzi0	282	22	virus	virus	NN
cord-002407-25cawzi0	282	23	strains	strain	NNS
cord-002407-25cawzi0	282	24	in	in	IN
cord-002407-25cawzi0	282	25	different	different	JJ
cord-002407-25cawzi0	282	26	animal	animal	NN
cord-002407-25cawzi0	282	27	models	model	NNS
cord-002407-25cawzi0	282	28	.	.	.
cord-002407-25cawzi0	283	1	The	the	DT
cord-002407-25cawzi0	283	2	genetic	genetic	JJ
cord-002407-25cawzi0	283	3	code	code	NN
cord-002407-25cawzi0	283	4	in	in	IN
cord-002407-25cawzi0	283	5	animals	animal	NNS
cord-002407-25cawzi0	283	6	encodes	encode	VBZ
cord-002407-25cawzi0	283	7	for	for	IN
cord-002407-25cawzi0	283	8	20	20	CD
cord-002407-25cawzi0	283	9	different	different	JJ
cord-002407-25cawzi0	283	10	amino	amino	NN
cord-002407-25cawzi0	283	11	acids	acid	NNS
cord-002407-25cawzi0	283	12	(	(	-LRB-
cord-002407-25cawzi0	283	13	aa	aa	NNP
cord-002407-25cawzi0	283	14	)	)	-RRB-
cord-002407-25cawzi0	283	15	using	use	VBG
cord-002407-25cawzi0	283	16	61	61	CD
cord-002407-25cawzi0	283	17	codons	codon	NNS
cord-002407-25cawzi0	283	18	.	.	.
cord-002407-25cawzi0	284	1	This	this	DT
cord-002407-25cawzi0	284	2	degeneracy	degeneracy	NN
cord-002407-25cawzi0	284	3	of	of	IN
cord-002407-25cawzi0	284	4	the	the	DT
cord-002407-25cawzi0	284	5	genetic	genetic	JJ
cord-002407-25cawzi0	284	6	code	code	NN
cord-002407-25cawzi0	284	7	allows	allow	VBZ
cord-002407-25cawzi0	284	8	amino	amino	JJ
cord-002407-25cawzi0	284	9	acids	acid	NNS
cord-002407-25cawzi0	284	10	,	,	,
cord-002407-25cawzi0	284	11	except	except	IN
cord-002407-25cawzi0	284	12	tryptophan	tryptophan	NN
cord-002407-25cawzi0	284	13	(	(	-LRB-
cord-002407-25cawzi0	284	14	W	w	NN
cord-002407-25cawzi0	284	15	)	)	-RRB-
cord-002407-25cawzi0	284	16	and	and	CC
cord-002407-25cawzi0	284	17	methionine	methionine	FW
cord-002407-25cawzi0	284	18	(	(	-LRB-
cord-002407-25cawzi0	284	19	M	M	NNP
cord-002407-25cawzi0	284	20	)	)	-RRB-
cord-002407-25cawzi0	284	21	,	,	,
cord-002407-25cawzi0	284	22	to	to	TO
cord-002407-25cawzi0	284	23	be	be	VB
cord-002407-25cawzi0	284	24	encoded	encode	VBN
cord-002407-25cawzi0	284	25	by	by	IN
cord-002407-25cawzi0	284	26	more	more	JJR
cord-002407-25cawzi0	284	27	than	than	IN
cord-002407-25cawzi0	284	28	one	one	CD
cord-002407-25cawzi0	284	29	synonymous	synonymous	JJ
cord-002407-25cawzi0	284	30	codon	codon	NN
cord-002407-25cawzi0	284	31	[	[	-LRB-
cord-002407-25cawzi0	284	32	46	46	CD
cord-002407-25cawzi0	284	33	]	]	-RRB-
cord-002407-25cawzi0	284	34	.	.	.
cord-002407-25cawzi0	285	1	Viruses	virus	NNS
cord-002407-25cawzi0	285	2	,	,	,
cord-002407-25cawzi0	285	3	including	include	VBG
cord-002407-25cawzi0	285	4	influenza	influenza	NN
cord-002407-25cawzi0	285	5	,	,	,
cord-002407-25cawzi0	285	6	rely	rely	VB
cord-002407-25cawzi0	285	7	on	on	IN
cord-002407-25cawzi0	285	8	the	the	DT
cord-002407-25cawzi0	285	9	host	host	NN
cord-002407-25cawzi0	285	10	cell	cell	NN
cord-002407-25cawzi0	285	11	translation	translation	NN
cord-002407-25cawzi0	285	12	machinery	machinery	NN
cord-002407-25cawzi0	285	13	to	to	TO
cord-002407-25cawzi0	285	14	synthesize	synthesize	VB
cord-002407-25cawzi0	285	15	their	-PRON-	PRP$
cord-002407-25cawzi0	285	16	viral	viral	JJ
cord-002407-25cawzi0	285	17	proteins	protein	NNS
cord-002407-25cawzi0	285	18	for	for	IN
cord-002407-25cawzi0	285	19	the	the	DT
cord-002407-25cawzi0	285	20	formation	formation	NN
cord-002407-25cawzi0	285	21	of	of	IN
cord-002407-25cawzi0	285	22	infectious	infectious	JJ
cord-002407-25cawzi0	285	23	virus	virus	NN
cord-002407-25cawzi0	285	24	progeny	progeny	NN
cord-002407-25cawzi0	285	25	.	.	.
cord-002407-25cawzi0	286	1	As	as	IN
cord-002407-25cawzi0	286	2	an	an	DT
cord-002407-25cawzi0	286	3	evolutionary	evolutionary	JJ
cord-002407-25cawzi0	286	4	consequence	consequence	NN
cord-002407-25cawzi0	286	5	,	,	,
cord-002407-25cawzi0	286	6	viruses	virus	NNS
cord-002407-25cawzi0	286	7	have	have	VBP
cord-002407-25cawzi0	286	8	modified	modify	VBN
cord-002407-25cawzi0	286	9	their	-PRON-	PRP$
cord-002407-25cawzi0	286	10	codon	codon	NN
cord-002407-25cawzi0	286	11	usage	usage	NN
cord-002407-25cawzi0	286	12	according	accord	VBG
cord-002407-25cawzi0	286	13	to	to	IN
cord-002407-25cawzi0	286	14	the	the	DT
cord-002407-25cawzi0	286	15	host	host	NN
cord-002407-25cawzi0	286	16	they	-PRON-	PRP
cord-002407-25cawzi0	286	17	infect	infect	VBP
cord-002407-25cawzi0	286	18	[	[	-LRB-
cord-002407-25cawzi0	286	19	182	182	CD
cord-002407-25cawzi0	286	20	]	]	-RRB-
cord-002407-25cawzi0	286	21	.	.	.
cord-002407-25cawzi0	287	1	Experimentally	experimentally	RB
cord-002407-25cawzi0	287	2	,	,	,
cord-002407-25cawzi0	287	3	protein	protein	NN
cord-002407-25cawzi0	287	4	synthesis	synthesis	NN
cord-002407-25cawzi0	287	5	can	can	MD
cord-002407-25cawzi0	287	6	be	be	VB
cord-002407-25cawzi0	287	7	downregulated	downregulate	VBN
cord-002407-25cawzi0	287	8	by	by	IN
cord-002407-25cawzi0	287	9	synthetically	synthetically	RB
cord-002407-25cawzi0	287	10	deoptimizing	deoptimize	VBG
cord-002407-25cawzi0	287	11	the	the	DT
cord-002407-25cawzi0	287	12	codon	codon	NN
cord-002407-25cawzi0	287	13	usage	usage	NN
cord-002407-25cawzi0	287	14	of	of	IN
cord-002407-25cawzi0	287	15	a	a	DT
cord-002407-25cawzi0	287	16	gene	gene	NN
cord-002407-25cawzi0	287	17	[	[	-LRB-
cord-002407-25cawzi0	287	18	141	141	CD
cord-002407-25cawzi0	287	19	,	,	,
cord-002407-25cawzi0	287	20	182	182	CD
cord-002407-25cawzi0	287	21	]	]	-RRB-
cord-002407-25cawzi0	287	22	.	.	.
cord-002407-25cawzi0	288	1	The	the	DT
cord-002407-25cawzi0	288	2	generation	generation	NN
cord-002407-25cawzi0	288	3	of	of	IN
cord-002407-25cawzi0	288	4	recombinant	recombinant	JJ
cord-002407-25cawzi0	288	5	viruses	virus	NNS
cord-002407-25cawzi0	288	6	containing	contain	VBG
cord-002407-25cawzi0	288	7	genes	gene	NNS
cord-002407-25cawzi0	288	8	with	with	IN
cord-002407-25cawzi0	288	9	deoptimized	deoptimize	VBN
cord-002407-25cawzi0	288	10	codons	codon	NNS
cord-002407-25cawzi0	288	11	is	be	VBZ
cord-002407-25cawzi0	288	12	now	now	RB
cord-002407-25cawzi0	288	13	feasible	feasible	JJ
cord-002407-25cawzi0	288	14	[	[	-LRB-
cord-002407-25cawzi0	288	15	141	141	CD
cord-002407-25cawzi0	288	16	,	,	,
cord-002407-25cawzi0	288	17	182	182	CD
cord-002407-25cawzi0	288	18	]	]	-RRB-
cord-002407-25cawzi0	288	19	,	,	,
cord-002407-25cawzi0	288	20	and	and	CC
cord-002407-25cawzi0	288	21	their	-PRON-	PRP$
cord-002407-25cawzi0	288	22	level	level	NN
cord-002407-25cawzi0	288	23	of	of	IN
cord-002407-25cawzi0	288	24	attenuation	attenuation	NN
cord-002407-25cawzi0	288	25	depends	depend	VBZ
cord-002407-25cawzi0	288	26	on	on	IN
cord-002407-25cawzi0	288	27	the	the	DT
cord-002407-25cawzi0	288	28	viral	viral	JJ
cord-002407-25cawzi0	288	29	gene	gene	NN
cord-002407-25cawzi0	288	30	targeted	target	VBN
cord-002407-25cawzi0	288	31	and	and	CC
cord-002407-25cawzi0	288	32	the	the	DT
cord-002407-25cawzi0	288	33	number	number	NN
cord-002407-25cawzi0	288	34	of	of	IN
cord-002407-25cawzi0	288	35	codon	codon	NN
cord-002407-25cawzi0	288	36	changes	change	NNS
cord-002407-25cawzi0	288	37	made	make	VBN
cord-002407-25cawzi0	288	38	during	during	IN
cord-002407-25cawzi0	288	39	the	the	DT
cord-002407-25cawzi0	288	40	codon	codon	NN
cord-002407-25cawzi0	288	41	deoptimization	deoptimization	NN
cord-002407-25cawzi0	288	42	process	process	NN
cord-002407-25cawzi0	288	43	[	[	-LRB-
cord-002407-25cawzi0	288	44	182	182	CD
cord-002407-25cawzi0	288	45	]	]	-RRB-
cord-002407-25cawzi0	288	46	.	.	.
cord-002407-25cawzi0	289	1	For	for	IN
cord-002407-25cawzi0	289	2	influenza	influenza	NN
cord-002407-25cawzi0	289	3	viruses	virus	NNS
cord-002407-25cawzi0	289	4	,	,	,
cord-002407-25cawzi0	289	5	many	many	JJ
cord-002407-25cawzi0	289	6	regions	region	NNS
cord-002407-25cawzi0	289	7	in	in	IN
cord-002407-25cawzi0	289	8	the	the	DT
cord-002407-25cawzi0	289	9	viral	viral	JJ
cord-002407-25cawzi0	289	10	genome	genome	NN
cord-002407-25cawzi0	289	11	can	can	MD
cord-002407-25cawzi0	289	12	not	not	RB
cord-002407-25cawzi0	289	13	be	be	VB
cord-002407-25cawzi0	289	14	altered	alter	VBN
cord-002407-25cawzi0	289	15	because	because	IN
cord-002407-25cawzi0	289	16	of	of	IN
cord-002407-25cawzi0	289	17	their	-PRON-	PRP$
cord-002407-25cawzi0	289	18	important	important	JJ
cord-002407-25cawzi0	289	19	role	role	NN
cord-002407-25cawzi0	289	20	in	in	IN
cord-002407-25cawzi0	289	21	viral	viral	JJ
cord-002407-25cawzi0	289	22	replication	replication	NN
cord-002407-25cawzi0	289	23	and	and	CC
cord-002407-25cawzi0	289	24	transcription	transcription	NN
cord-002407-25cawzi0	289	25	(	(	-LRB-
cord-002407-25cawzi0	289	26	e.g.	e.g.	RB
cord-002407-25cawzi0	289	27	,	,	,
cord-002407-25cawzi0	289	28	NCRs	NCRs	NNP
cord-002407-25cawzi0	289	29	)	)	-RRB-
cord-002407-25cawzi0	289	30	,	,	,
cord-002407-25cawzi0	289	31	packaging	packaging	NN
cord-002407-25cawzi0	289	32	(	(	-LRB-
cord-002407-25cawzi0	289	33	e.g.	e.g.	RB
cord-002407-25cawzi0	289	34	,	,	,
cord-002407-25cawzi0	289	35	packaging	packaging	NN
cord-002407-25cawzi0	289	36	signals	signal	NNS
cord-002407-25cawzi0	289	37	)	)	-RRB-
cord-002407-25cawzi0	289	38	,	,	,
cord-002407-25cawzi0	289	39	the	the	DT
cord-002407-25cawzi0	289	40	presence	presence	NN
cord-002407-25cawzi0	289	41	of	of	IN
cord-002407-25cawzi0	289	42	multiple	multiple	JJ
cord-002407-25cawzi0	289	43	overlapping	overlap	VBG
cord-002407-25cawzi0	289	44	ORFs	orfs	NN
cord-002407-25cawzi0	289	45	(	(	-LRB-
cord-002407-25cawzi0	289	46	e.g.	e.g.	RB
cord-002407-25cawzi0	289	47	,	,	,
cord-002407-25cawzi0	289	48	segments	segment	NNS
cord-002407-25cawzi0	289	49	7	7	CD
cord-002407-25cawzi0	289	50	and	and	CC
cord-002407-25cawzi0	289	51	8)	8)	NN
cord-002407-25cawzi0	289	52	,	,	,
cord-002407-25cawzi0	289	53	etc	etc	FW
cord-002407-25cawzi0	289	54	.	.	.
cord-002407-25cawzi0	290	1	[	[	-LRB-
cord-002407-25cawzi0	290	2	48	48	CD
cord-002407-25cawzi0	290	3	]	]	-RRB-
cord-002407-25cawzi0	290	4	.	.	.
cord-002407-25cawzi0	291	1	To	to	IN
cord-002407-25cawzi0	291	2	date	date	NN
cord-002407-25cawzi0	291	3	,	,	,
cord-002407-25cawzi0	291	4	recombinant	recombinant	JJ
cord-002407-25cawzi0	291	5	IAVs	iav	NNS
cord-002407-25cawzi0	291	6	that	that	WDT
cord-002407-25cawzi0	291	7	have	have	VBP
cord-002407-25cawzi0	291	8	been	be	VBN
cord-002407-25cawzi0	291	9	attenuated	attenuate	VBN
cord-002407-25cawzi0	291	10	using	use	VBG
cord-002407-25cawzi0	291	11	a	a	DT
cord-002407-25cawzi0	291	12	codon	codon	NN
cord-002407-25cawzi0	291	13	-	-	HYPH
cord-002407-25cawzi0	291	14	pair	pair	NN
cord-002407-25cawzi0	291	15	[	[	-LRB-
cord-002407-25cawzi0	291	16	183	183	CD
cord-002407-25cawzi0	291	17	,	,	,
cord-002407-25cawzi0	291	18	184	184	CD
cord-002407-25cawzi0	291	19	]	]	-RRB-
cord-002407-25cawzi0	291	20	or	or	CC
cord-002407-25cawzi0	291	21	a	a	DT
cord-002407-25cawzi0	291	22	codon	codon	NN
cord-002407-25cawzi0	291	23	bias	bias	NN
cord-002407-25cawzi0	291	24	[	[	-LRB-
cord-002407-25cawzi0	291	25	182	182	CD
cord-002407-25cawzi0	291	26	]	]	-RRB-
cord-002407-25cawzi0	291	27	deoptimization	deoptimization	NN
cord-002407-25cawzi0	291	28	approach	approach	NN
cord-002407-25cawzi0	291	29	to	to	TO
cord-002407-25cawzi0	291	30	decrease	decrease	VB
cord-002407-25cawzi0	291	31	expression	expression	NN
cord-002407-25cawzi0	291	32	levels	level	NNS
cord-002407-25cawzi0	291	33	of	of	IN
cord-002407-25cawzi0	291	34	the	the	DT
cord-002407-25cawzi0	291	35	viral	viral	JJ
cord-002407-25cawzi0	291	36	PB1	pb1	NN
cord-002407-25cawzi0	291	37	,	,	,
cord-002407-25cawzi0	291	38	HA	HA	NNP
cord-002407-25cawzi0	291	39	and	and	CC
cord-002407-25cawzi0	291	40	NP	NP	NNP
cord-002407-25cawzi0	291	41	[	[	-LRB-
cord-002407-25cawzi0	291	42	183	183	CD
cord-002407-25cawzi0	291	43	]	]	-RRB-
cord-002407-25cawzi0	291	44	,	,	,
cord-002407-25cawzi0	291	45	NA	NA	NNP
cord-002407-25cawzi0	291	46	and	and	CC
cord-002407-25cawzi0	291	47	HA	HA	NNP
cord-002407-25cawzi0	291	48	[	[	-LRB-
cord-002407-25cawzi0	291	49	184	184	CD
cord-002407-25cawzi0	291	50	]	]	-RRB-
cord-002407-25cawzi0	291	51	or	or	CC
cord-002407-25cawzi0	291	52	NS1	NS1	NNS
cord-002407-25cawzi0	291	53	and	and	CC
cord-002407-25cawzi0	291	54	NEP	NEP	NNP
cord-002407-25cawzi0	291	55	[	[	-LRB-
cord-002407-25cawzi0	291	56	182	182	CD
cord-002407-25cawzi0	291	57	]	]	-RRB-
cord-002407-25cawzi0	291	58	have	have	VBP
cord-002407-25cawzi0	291	59	been	be	VBN
cord-002407-25cawzi0	291	60	generated	generate	VBN
cord-002407-25cawzi0	291	61	.	.	.
cord-002407-25cawzi0	292	1	Importantly	importantly	RB
cord-002407-25cawzi0	292	2	,	,	,
cord-002407-25cawzi0	292	3	influenza	influenza	NN
cord-002407-25cawzi0	292	4	viruses	virus	NNS
cord-002407-25cawzi0	292	5	generated	generate	VBN
cord-002407-25cawzi0	292	6	by	by	IN
cord-002407-25cawzi0	292	7	codon	codon	NNP
cord-002407-25cawzi0	292	8	deoptimization	deoptimization	NN
cord-002407-25cawzi0	292	9	showed	show	VBD
cord-002407-25cawzi0	292	10	similar	similar	JJ
cord-002407-25cawzi0	292	11	viral	viral	JJ
cord-002407-25cawzi0	292	12	replication	replication	NN
cord-002407-25cawzi0	292	13	kinetics	kinetic	NNS
cord-002407-25cawzi0	292	14	to	to	IN
cord-002407-25cawzi0	292	15	WT	WT	NNP
cord-002407-25cawzi0	292	16	virus	virus	NN
cord-002407-25cawzi0	292	17	in	in	IN
cord-002407-25cawzi0	292	18	MDCK	MDCK	NNP
cord-002407-25cawzi0	292	19	cells	cell	NNS
cord-002407-25cawzi0	292	20	,	,	,
cord-002407-25cawzi0	292	21	which	which	WDT
cord-002407-25cawzi0	292	22	is	be	VBZ
cord-002407-25cawzi0	292	23	important	important	JJ
cord-002407-25cawzi0	292	24	for	for	IN
cord-002407-25cawzi0	292	25	their	-PRON-	PRP$
cord-002407-25cawzi0	292	26	effective	effective	JJ
cord-002407-25cawzi0	292	27	use	use	NN
cord-002407-25cawzi0	292	28	for	for	IN
cord-002407-25cawzi0	292	29	vaccine	vaccine	NN
cord-002407-25cawzi0	292	30	production	production	NN
cord-002407-25cawzi0	292	31	.	.	.
cord-002407-25cawzi0	293	1	However	however	RB
cord-002407-25cawzi0	293	2	,	,	,
cord-002407-25cawzi0	293	3	to	to	IN
cord-002407-25cawzi0	293	4	date	date	NN
cord-002407-25cawzi0	293	5	,	,	,
cord-002407-25cawzi0	293	6	the	the	DT
cord-002407-25cawzi0	293	7	ability	ability	NN
cord-002407-25cawzi0	293	8	of	of	IN
cord-002407-25cawzi0	293	9	these	these	DT
cord-002407-25cawzi0	293	10	recombinant	recombinant	JJ
cord-002407-25cawzi0	293	11	IAVs	iav	NNS
cord-002407-25cawzi0	293	12	containing	contain	VBG
cord-002407-25cawzi0	293	13	codon	codon	NN
cord-002407-25cawzi0	293	14	-	-	HYPH
cord-002407-25cawzi0	293	15	pair	pair	NN
cord-002407-25cawzi0	293	16	or	or	CC
cord-002407-25cawzi0	293	17	codon	codon	NN
cord-002407-25cawzi0	293	18	bias	bias	NN
cord-002407-25cawzi0	293	19	deoptimized	deoptimize	VBD
cord-002407-25cawzi0	293	20	viral	viral	JJ
cord-002407-25cawzi0	293	21	segments	segment	NNS
cord-002407-25cawzi0	293	22	to	to	TO
cord-002407-25cawzi0	293	23	replicate	replicate	VB
cord-002407-25cawzi0	293	24	in	in	IN
cord-002407-25cawzi0	293	25	eggs	egg	NNS
cord-002407-25cawzi0	293	26	has	have	VBZ
cord-002407-25cawzi0	293	27	not	not	RB
cord-002407-25cawzi0	293	28	yet	yet	RB
cord-002407-25cawzi0	293	29	been	be	VBN
cord-002407-25cawzi0	293	30	evaluated	evaluate	VBN
cord-002407-25cawzi0	293	31	.	.	.
cord-002407-25cawzi0	294	1	Importantly	importantly	RB
cord-002407-25cawzi0	294	2	,	,	,
cord-002407-25cawzi0	294	3	all	all	DT
cord-002407-25cawzi0	294	4	of	of	IN
cord-002407-25cawzi0	294	5	the	the	DT
cord-002407-25cawzi0	294	6	codon	codon	NN
cord-002407-25cawzi0	294	7	deoptimized	deoptimize	VBN
cord-002407-25cawzi0	294	8	IAVs	iav	NNS
cord-002407-25cawzi0	294	9	were	be	VBD
cord-002407-25cawzi0	294	10	attenuated	attenuate	VBN
cord-002407-25cawzi0	294	11	in	in	IN
cord-002407-25cawzi0	294	12	mice	mouse	NNS
cord-002407-25cawzi0	294	13	and	and	CC
cord-002407-25cawzi0	294	14	able	able	JJ
cord-002407-25cawzi0	294	15	to	to	TO
cord-002407-25cawzi0	294	16	provide	provide	VB
cord-002407-25cawzi0	294	17	,	,	,
cord-002407-25cawzi0	294	18	upon	upon	IN
cord-002407-25cawzi0	294	19	a	a	DT
cord-002407-25cawzi0	294	20	single	single	JJ
cord-002407-25cawzi0	294	21	immunization	immunization	NN
cord-002407-25cawzi0	294	22	dose	dose	NN
cord-002407-25cawzi0	294	23	,	,	,
cord-002407-25cawzi0	294	24	protection	protection	NN
cord-002407-25cawzi0	294	25	against	against	IN
cord-002407-25cawzi0	294	26	a	a	DT
cord-002407-25cawzi0	294	27	lethal	lethal	JJ
cord-002407-25cawzi0	294	28	challenge	challenge	NN
cord-002407-25cawzi0	294	29	with	with	IN
cord-002407-25cawzi0	294	30	a	a	DT
cord-002407-25cawzi0	294	31	WT	WT	NNP
cord-002407-25cawzi0	294	32	form	form	NN
cord-002407-25cawzi0	294	33	of	of	IN
cord-002407-25cawzi0	294	34	the	the	DT
cord-002407-25cawzi0	294	35	virus	virus	NN
cord-002407-25cawzi0	294	36	,	,	,
cord-002407-25cawzi0	294	37	showing	show	VBG
cord-002407-25cawzi0	294	38	that	that	IN
cord-002407-25cawzi0	294	39	LAIVs	laiv	NNS
cord-002407-25cawzi0	294	40	were	be	VBD
cord-002407-25cawzi0	294	41	safe	safe	JJ
cord-002407-25cawzi0	294	42	,	,	,
cord-002407-25cawzi0	294	43	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	294	44	and	and	CC
cord-002407-25cawzi0	294	45	protective	protective	JJ
cord-002407-25cawzi0	294	46	.	.	.
cord-002407-25cawzi0	295	1	However	however	RB
cord-002407-25cawzi0	295	2	,	,	,
cord-002407-25cawzi0	295	3	mice	mouse	NNS
cord-002407-25cawzi0	295	4	do	do	VBP
cord-002407-25cawzi0	295	5	not	not	RB
cord-002407-25cawzi0	295	6	accurately	accurately	RB
cord-002407-25cawzi0	295	7	reflect	reflect	VB
cord-002407-25cawzi0	295	8	virus	virus	NN
cord-002407-25cawzi0	295	9	pathogenesis	pathogenesis	NN
cord-002407-25cawzi0	295	10	and	and	CC
cord-002407-25cawzi0	295	11	immunological	immunological	JJ
cord-002407-25cawzi0	295	12	responses	response	NNS
cord-002407-25cawzi0	295	13	seen	see	VBN
cord-002407-25cawzi0	295	14	in	in	IN
cord-002407-25cawzi0	295	15	humans	human	NNS
cord-002407-25cawzi0	295	16	[	[	-LRB-
cord-002407-25cawzi0	295	17	81	81	CD
cord-002407-25cawzi0	295	18	]	]	-RRB-
cord-002407-25cawzi0	295	19	and	and	CC
cord-002407-25cawzi0	295	20	do	do	VBP
cord-002407-25cawzi0	295	21	not	not	RB
cord-002407-25cawzi0	295	22	have	have	VB
cord-002407-25cawzi0	295	23	the	the	DT
cord-002407-25cawzi0	295	24	same	same	JJ
cord-002407-25cawzi0	295	25	codon	codon	NN
cord-002407-25cawzi0	295	26	usage	usage	NN
cord-002407-25cawzi0	295	27	bias	bias	NN
cord-002407-25cawzi0	295	28	as	as	IN
cord-002407-25cawzi0	295	29	humans	human	NNS
cord-002407-25cawzi0	295	30	.	.	.
cord-002407-25cawzi0	296	1	Therefore	therefore	RB
cord-002407-25cawzi0	296	2	,	,	,
cord-002407-25cawzi0	296	3	studies	study	NNS
cord-002407-25cawzi0	296	4	aimed	aim	VBN
cord-002407-25cawzi0	296	5	to	to	TO
cord-002407-25cawzi0	296	6	demonstrate	demonstrate	VB
cord-002407-25cawzi0	296	7	the	the	DT
cord-002407-25cawzi0	296	8	safety	safety	NN
cord-002407-25cawzi0	296	9	,	,	,
cord-002407-25cawzi0	296	10	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	296	11	and	and	CC
cord-002407-25cawzi0	296	12	protection	protection	NN
cord-002407-25cawzi0	296	13	efficacy	efficacy	NN
cord-002407-25cawzi0	296	14	of	of	IN
cord-002407-25cawzi0	296	15	codon	codon	NN
cord-002407-25cawzi0	296	16	deoptimized	deoptimize	VBN
cord-002407-25cawzi0	296	17	recombinant	recombinant	JJ
cord-002407-25cawzi0	296	18	IAVs	iav	NNS
cord-002407-25cawzi0	296	19	in	in	IN
cord-002407-25cawzi0	296	20	other	other	JJ
cord-002407-25cawzi0	296	21	well	well	RB
cord-002407-25cawzi0	296	22	-	-	HYPH
cord-002407-25cawzi0	296	23	established	establish	VBN
cord-002407-25cawzi0	296	24	animal	animal	NN
cord-002407-25cawzi0	296	25	models	model	NNS
cord-002407-25cawzi0	296	26	of	of	IN
cord-002407-25cawzi0	296	27	influenza	influenza	NN
cord-002407-25cawzi0	296	28	(	(	-LRB-
cord-002407-25cawzi0	296	29	e.g.	e.g.	RB
cord-002407-25cawzi0	296	30	,	,	,
cord-002407-25cawzi0	296	31	guinea	guinea	NN
cord-002407-25cawzi0	296	32	pigs	pig	NNS
cord-002407-25cawzi0	296	33	,	,	,
cord-002407-25cawzi0	296	34	ferrets	ferret	NNS
cord-002407-25cawzi0	296	35	or	or	CC
cord-002407-25cawzi0	296	36	nonhuman	nonhuman	NN
cord-002407-25cawzi0	296	37	primates	primate	NNS
cord-002407-25cawzi0	296	38	)	)	-RRB-
cord-002407-25cawzi0	296	39	could	could	MD
cord-002407-25cawzi0	296	40	lead	lead	VB
cord-002407-25cawzi0	296	41	to	to	IN
cord-002407-25cawzi0	296	42	their	-PRON-	PRP$
cord-002407-25cawzi0	296	43	implementation	implementation	NN
cord-002407-25cawzi0	296	44	as	as	IN
cord-002407-25cawzi0	296	45	LAIVs	laiv	NNS
cord-002407-25cawzi0	296	46	in	in	IN
cord-002407-25cawzi0	296	47	future	future	JJ
cord-002407-25cawzi0	296	48	vaccinations	vaccination	NNS
cord-002407-25cawzi0	296	49	[	[	-LRB-
cord-002407-25cawzi0	296	50	141	141	CD
cord-002407-25cawzi0	296	51	]	]	-RRB-
cord-002407-25cawzi0	296	52	.	.	.
cord-002407-25cawzi0	297	1	Other	other	JJ
cord-002407-25cawzi0	297	2	promising	promising	JJ
cord-002407-25cawzi0	297	3	approaches	approach	NNS
cord-002407-25cawzi0	297	4	for	for	IN
cord-002407-25cawzi0	297	5	the	the	DT
cord-002407-25cawzi0	297	6	development	development	NN
cord-002407-25cawzi0	297	7	of	of	IN
cord-002407-25cawzi0	297	8	LAIVs	laiv	NNS
cord-002407-25cawzi0	297	9	relate	relate	VBP
cord-002407-25cawzi0	297	10	to	to	IN
cord-002407-25cawzi0	297	11	the	the	DT
cord-002407-25cawzi0	297	12	use	use	NN
cord-002407-25cawzi0	297	13	of	of	IN
cord-002407-25cawzi0	297	14	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	297	15	[	[	-LRB-
cord-002407-25cawzi0	297	16	144	144	CD
cord-002407-25cawzi0	297	17	]	]	-RRB-
cord-002407-25cawzi0	297	18	.	.	.
cord-002407-25cawzi0	298	1	SciIAVs	sciiav	NNS
cord-002407-25cawzi0	298	2	based	base	VBN
cord-002407-25cawzi0	298	3	on	on	IN
cord-002407-25cawzi0	298	4	their	-PRON-	PRP$
cord-002407-25cawzi0	298	5	safety	safety	NN
cord-002407-25cawzi0	298	6	profile	profile	NN
cord-002407-25cawzi0	298	7	,	,	,
cord-002407-25cawzi0	298	8	ability	ability	NN
cord-002407-25cawzi0	298	9	to	to	TO
cord-002407-25cawzi0	298	10	elicit	elicit	VB
cord-002407-25cawzi0	298	11	protective	protective	JJ
cord-002407-25cawzi0	298	12	humoral	humoral	JJ
cord-002407-25cawzi0	298	13	and	and	CC
cord-002407-25cawzi0	298	14	cellular	cellular	JJ
cord-002407-25cawzi0	298	15	responses	response	NNS
cord-002407-25cawzi0	298	16	and	and	CC
cord-002407-25cawzi0	298	17	protective	protective	JJ
cord-002407-25cawzi0	298	18	effectiveness	effectiveness	NN
cord-002407-25cawzi0	298	19	represent	represent	VBP
cord-002407-25cawzi0	298	20	a	a	DT
cord-002407-25cawzi0	298	21	feasible	feasible	JJ
cord-002407-25cawzi0	298	22	alternative	alternative	NN
cord-002407-25cawzi0	298	23	to	to	IN
cord-002407-25cawzi0	298	24	current	current	JJ
cord-002407-25cawzi0	298	25	influenza	influenza	NN
cord-002407-25cawzi0	298	26	vaccines	vaccine	NNS
cord-002407-25cawzi0	298	27	for	for	IN
cord-002407-25cawzi0	298	28	the	the	DT
cord-002407-25cawzi0	298	29	treatment	treatment	NN
cord-002407-25cawzi0	298	30	of	of	IN
cord-002407-25cawzi0	298	31	influenza	influenza	NN
cord-002407-25cawzi0	298	32	viral	viral	JJ
cord-002407-25cawzi0	298	33	infections	infection	NNS
cord-002407-25cawzi0	298	34	[	[	-LRB-
cord-002407-25cawzi0	298	35	69	69	CD
cord-002407-25cawzi0	298	36	,	,	,
cord-002407-25cawzi0	298	37	144	144	CD
cord-002407-25cawzi0	298	38	]	]	-RRB-
cord-002407-25cawzi0	298	39	.	.	.
cord-002407-25cawzi0	299	1	However	however	RB
cord-002407-25cawzi0	299	2	,	,	,
cord-002407-25cawzi0	299	3	to	to	IN
cord-002407-25cawzi0	299	4	date	date	NN
cord-002407-25cawzi0	299	5	,	,	,
cord-002407-25cawzi0	299	6	no	no	DT
cord-002407-25cawzi0	299	7	single	single	JJ
cord-002407-25cawzi0	299	8	-	-	HYPH
cord-002407-25cawzi0	299	9	cycle	cycle	NN
cord-002407-25cawzi0	299	10	infectious	infectious	JJ
cord-002407-25cawzi0	299	11	IBVs	ibv	NNS
cord-002407-25cawzi0	299	12	(	(	-LRB-
cord-002407-25cawzi0	299	13	sciIBV	sciIBV	NNP
cord-002407-25cawzi0	299	14	)	)	-RRB-
cord-002407-25cawzi0	299	15	have	have	VBP
cord-002407-25cawzi0	299	16	been	be	VBN
cord-002407-25cawzi0	299	17	reported	report	VBN
cord-002407-25cawzi0	299	18	.	.	.
cord-002407-25cawzi0	300	1	When	when	WRB
cord-002407-25cawzi0	300	2	delivered	deliver	VBN
cord-002407-25cawzi0	300	3	intranasally	intranasally	RB
cord-002407-25cawzi0	300	4	,	,	,
cord-002407-25cawzi0	300	5	sciIAV	sciIAV	NNP
cord-002407-25cawzi0	300	6	has	have	VBZ
cord-002407-25cawzi0	300	7	been	be	VBN
cord-002407-25cawzi0	300	8	shown	show	VBN
cord-002407-25cawzi0	300	9	to	to	TO
cord-002407-25cawzi0	300	10	be	be	VB
cord-002407-25cawzi0	300	11	safe	safe	JJ
cord-002407-25cawzi0	300	12	in	in	IN
cord-002407-25cawzi0	300	13	a	a	DT
cord-002407-25cawzi0	300	14	mouse	mouse	NN
cord-002407-25cawzi0	300	15	model	model	NN
cord-002407-25cawzi0	300	16	of	of	IN
cord-002407-25cawzi0	300	17	influenza	influenza	NN
cord-002407-25cawzi0	300	18	infection	infection	NN
cord-002407-25cawzi0	300	19	,	,	,
cord-002407-25cawzi0	300	20	without	without	IN
cord-002407-25cawzi0	300	21	signs	sign	NNS
cord-002407-25cawzi0	300	22	of	of	IN
cord-002407-25cawzi0	300	23	illness	illness	NN
cord-002407-25cawzi0	300	24	or	or	CC
cord-002407-25cawzi0	300	25	mortality	mortality	NN
cord-002407-25cawzi0	300	26	[	[	-LRB-
cord-002407-25cawzi0	300	27	69	69	CD
cord-002407-25cawzi0	300	28	,	,	,
cord-002407-25cawzi0	300	29	[	[	-LRB-
cord-002407-25cawzi0	300	30	185	185	CD
cord-002407-25cawzi0	300	31	]	]	-RRB-
cord-002407-25cawzi0	300	32	[	[	-LRB-
cord-002407-25cawzi0	300	33	186	186	CD
cord-002407-25cawzi0	300	34	]	]	-RRB-
cord-002407-25cawzi0	300	35	[	[	-LRB-
cord-002407-25cawzi0	300	36	187	187	CD
cord-002407-25cawzi0	300	37	]	]	-RRB-
cord-002407-25cawzi0	300	38	[	[	-LRB-
cord-002407-25cawzi0	300	39	188	188	CD
cord-002407-25cawzi0	300	40	]	]	-RRB-
cord-002407-25cawzi0	300	41	[	[	-LRB-
cord-002407-25cawzi0	300	42	189	189	CD
cord-002407-25cawzi0	300	43	]	]	-RRB-
cord-002407-25cawzi0	300	44	.	.	.
cord-002407-25cawzi0	301	1	Moreover	moreover	RB
cord-002407-25cawzi0	301	2	,	,	,
cord-002407-25cawzi0	301	3	and	and	CC
cord-002407-25cawzi0	301	4	similar	similar	JJ
cord-002407-25cawzi0	301	5	to	to	IN
cord-002407-25cawzi0	301	6	the	the	DT
cord-002407-25cawzi0	301	7	current	current	JJ
cord-002407-25cawzi0	301	8	LAIVs	laiv	NNS
cord-002407-25cawzi0	301	9	,	,	,
cord-002407-25cawzi0	301	10	intranasal	intranasal	NN
cord-002407-25cawzi0	301	11	immunization	immunization	NN
cord-002407-25cawzi0	301	12	with	with	IN
cord-002407-25cawzi0	301	13	a	a	DT
cord-002407-25cawzi0	301	14	single	single	JJ
cord-002407-25cawzi0	301	15	dose	dose	NN
cord-002407-25cawzi0	301	16	of	of	IN
cord-002407-25cawzi0	301	17	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	301	18	elicited	elicit	VBD
cord-002407-25cawzi0	301	19	localized	localize	VBN
cord-002407-25cawzi0	301	20	mucosal	mucosal	JJ
cord-002407-25cawzi0	301	21	immune	immune	JJ
cord-002407-25cawzi0	301	22	responses	response	NNS
cord-002407-25cawzi0	301	23	and	and	CC
cord-002407-25cawzi0	301	24	recruitment	recruitment	NN
cord-002407-25cawzi0	301	25	of	of	IN
cord-002407-25cawzi0	301	26	influenza	influenza	NN
cord-002407-25cawzi0	301	27	-	-	HYPH
cord-002407-25cawzi0	301	28	specific	specific	JJ
cord-002407-25cawzi0	301	29	CD8	CD8	NNP
cord-002407-25cawzi0	301	30	T	T	NNP
cord-002407-25cawzi0	301	31	-	-	HYPH
cord-002407-25cawzi0	301	32	cells	cell	NNS
cord-002407-25cawzi0	301	33	into	into	IN
cord-002407-25cawzi0	301	34	the	the	DT
cord-002407-25cawzi0	301	35	lungs	lung	NNS
cord-002407-25cawzi0	301	36	of	of	IN
cord-002407-25cawzi0	301	37	vaccinated	vaccinated	JJ
cord-002407-25cawzi0	301	38	animals	animal	NNS
cord-002407-25cawzi0	301	39	[	[	-LRB-
cord-002407-25cawzi0	301	40	145	145	CD
cord-002407-25cawzi0	301	41	,	,	,
cord-002407-25cawzi0	301	42	185	185	CD
cord-002407-25cawzi0	301	43	,	,	,
cord-002407-25cawzi0	301	44	186	186	CD
cord-002407-25cawzi0	301	45	,	,	,
cord-002407-25cawzi0	301	46	190	190	CD
cord-002407-25cawzi0	301	47	]	]	-RRB-
cord-002407-25cawzi0	301	48	,	,	,
cord-002407-25cawzi0	301	49	the	the	DT
cord-002407-25cawzi0	301	50	latest	late	JJS
cord-002407-25cawzi0	301	51	being	be	VBG
cord-002407-25cawzi0	301	52	the	the	DT
cord-002407-25cawzi0	301	53	main	main	JJ
cord-002407-25cawzi0	301	54	contributor	contributor	NN
cord-002407-25cawzi0	301	55	of	of	IN
cord-002407-25cawzi0	301	56	immunity	immunity	NN
cord-002407-25cawzi0	301	57	against	against	IN
cord-002407-25cawzi0	301	58	challenge	challenge	NN
cord-002407-25cawzi0	301	59	with	with	IN
cord-002407-25cawzi0	301	60	heterologous	heterologous	JJ
cord-002407-25cawzi0	301	61	influenza	influenza	NN
cord-002407-25cawzi0	301	62	viruses	virus	NNS
cord-002407-25cawzi0	301	63	[	[	-LRB-
cord-002407-25cawzi0	301	64	69	69	CD
cord-002407-25cawzi0	301	65	,	,	,
cord-002407-25cawzi0	301	66	190	190	CD
cord-002407-25cawzi0	301	67	]	]	-RRB-
cord-002407-25cawzi0	301	68	.	.	.
cord-002407-25cawzi0	302	1	Importantly	importantly	RB
cord-002407-25cawzi0	302	2	,	,	,
cord-002407-25cawzi0	302	3	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	302	4	protected	protect	VBD
cord-002407-25cawzi0	302	5	mice	mouse	NNS
cord-002407-25cawzi0	302	6	against	against	IN
cord-002407-25cawzi0	302	7	lethal	lethal	JJ
cord-002407-25cawzi0	302	8	influenza	influenza	NN
cord-002407-25cawzi0	302	9	virus	virus	NN
cord-002407-25cawzi0	302	10	challenges	challenge	VBZ
cord-002407-25cawzi0	302	11	[	[	-LRB-
cord-002407-25cawzi0	302	12	69	69	CD
cord-002407-25cawzi0	302	13	,	,	,
cord-002407-25cawzi0	302	14	144	144	CD
cord-002407-25cawzi0	302	15	]	]	-RRB-
cord-002407-25cawzi0	302	16	.	.	.
cord-002407-25cawzi0	303	1	Moreover	moreover	RB
cord-002407-25cawzi0	303	2	,	,	,
cord-002407-25cawzi0	303	3	similar	similar	JJ
cord-002407-25cawzi0	303	4	safety	safety	NN
cord-002407-25cawzi0	303	5	,	,	,
cord-002407-25cawzi0	303	6	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	303	7	and	and	CC
cord-002407-25cawzi0	303	8	protection	protection	NN
cord-002407-25cawzi0	303	9	efficacy	efficacy	NN
cord-002407-25cawzi0	303	10	of	of	IN
cord-002407-25cawzi0	303	11	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	303	12	were	be	VBD
cord-002407-25cawzi0	303	13	observed	observe	VBN
cord-002407-25cawzi0	303	14	in	in	IN
cord-002407-25cawzi0	303	15	ferrets	ferret	NNS
cord-002407-25cawzi0	303	16	[	[	-LRB-
cord-002407-25cawzi0	303	17	69	69	CD
cord-002407-25cawzi0	303	18	]	]	-RRB-
cord-002407-25cawzi0	303	19	.	.	.
cord-002407-25cawzi0	304	1	Vaccination	vaccination	NN
cord-002407-25cawzi0	304	2	of	of	IN
cord-002407-25cawzi0	304	3	pigs	pig	NNS
cord-002407-25cawzi0	304	4	with	with	IN
cord-002407-25cawzi0	304	5	sciIAV	sciIAV	NNS
cord-002407-25cawzi0	304	6	has	have	VBZ
cord-002407-25cawzi0	304	7	also	also	RB
cord-002407-25cawzi0	304	8	been	be	VBN
cord-002407-25cawzi0	304	9	shown	show	VBN
cord-002407-25cawzi0	304	10	to	to	TO
cord-002407-25cawzi0	304	11	be	be	VB
cord-002407-25cawzi0	304	12	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	304	13	and	and	CC
cord-002407-25cawzi0	304	14	protective	protective	JJ
cord-002407-25cawzi0	304	15	against	against	IN
cord-002407-25cawzi0	304	16	challenge	challenge	NN
cord-002407-25cawzi0	304	17	with	with	IN
cord-002407-25cawzi0	304	18	swine	swine	NN
cord-002407-25cawzi0	304	19	influenza	influenza	NN
cord-002407-25cawzi0	304	20	viruses	virus	NNS
cord-002407-25cawzi0	304	21	[	[	-LRB-
cord-002407-25cawzi0	304	22	191	191	CD
cord-002407-25cawzi0	304	23	]	]	-RRB-
cord-002407-25cawzi0	304	24	.	.	.
cord-002407-25cawzi0	305	1	Moreover	moreover	RB
cord-002407-25cawzi0	305	2	,	,	,
cord-002407-25cawzi0	305	3	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	305	4	expressing	express	VBG
cord-002407-25cawzi0	305	5	foreign	foreign	JJ
cord-002407-25cawzi0	305	6	genes	gene	NNS
cord-002407-25cawzi0	305	7	represent	represent	VBP
cord-002407-25cawzi0	305	8	an	an	DT
cord-002407-25cawzi0	305	9	excellent	excellent	JJ
cord-002407-25cawzi0	305	10	option	option	NN
cord-002407-25cawzi0	305	11	for	for	IN
cord-002407-25cawzi0	305	12	their	-PRON-	PRP$
cord-002407-25cawzi0	305	13	implementation	implementation	NN
cord-002407-25cawzi0	305	14	as	as	IN
cord-002407-25cawzi0	305	15	bivalent	bivalent	JJ
cord-002407-25cawzi0	305	16	vaccines	vaccine	NNS
cord-002407-25cawzi0	305	17	.	.	.
cord-002407-25cawzi0	306	1	For	for	IN
cord-002407-25cawzi0	306	2	instance	instance	NN
cord-002407-25cawzi0	306	3	,	,	,
cord-002407-25cawzi0	306	4	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	306	5	expressing	express	VBG
cord-002407-25cawzi0	306	6	the	the	DT
cord-002407-25cawzi0	306	7	surface	surface	NN
cord-002407-25cawzi0	306	8	protein	protein	NN
cord-002407-25cawzi0	306	9	A	A	NNP
cord-002407-25cawzi0	306	10	(	(	-LRB-
cord-002407-25cawzi0	306	11	PspA	PspA	NNP
cord-002407-25cawzi0	306	12	)	)	-RRB-
cord-002407-25cawzi0	306	13	of	of	IN
cord-002407-25cawzi0	306	14	Streptococcus	Streptococcus	NNP
cord-002407-25cawzi0	306	15	pneumoniae	pneumoniae	NN
cord-002407-25cawzi0	306	16	,	,	,
cord-002407-25cawzi0	306	17	the	the	DT
cord-002407-25cawzi0	306	18	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	306	19	-	-	,
cord-002407-25cawzi0	306	20	neuraminidase	neuraminidase	FW
cord-002407-25cawzi0	306	21	(	(	-LRB-
cord-002407-25cawzi0	306	22	HN	HN	NNP
cord-002407-25cawzi0	306	23	)	)	-RRB-
cord-002407-25cawzi0	306	24	protein	protein	NN
cord-002407-25cawzi0	306	25	of	of	IN
cord-002407-25cawzi0	306	26	HPIV-3	HPIV-3	NNP
cord-002407-25cawzi0	306	27	or	or	CC
cord-002407-25cawzi0	306	28	the	the	DT
cord-002407-25cawzi0	306	29	fusion	fusion	NN
cord-002407-25cawzi0	306	30	(	(	-LRB-
cord-002407-25cawzi0	306	31	F	F	NNP
cord-002407-25cawzi0	306	32	)	)	-RRB-
cord-002407-25cawzi0	306	33	protein	protein	NN
cord-002407-25cawzi0	306	34	of	of	IN
cord-002407-25cawzi0	306	35	respiratory	respiratory	JJ
cord-002407-25cawzi0	306	36	syncytial	syncytial	JJ
cord-002407-25cawzi0	306	37	virus	virus	NN
cord-002407-25cawzi0	306	38	(	(	-LRB-
cord-002407-25cawzi0	306	39	RSV	RSV	NNP
cord-002407-25cawzi0	306	40	)	)	-RRB-
cord-002407-25cawzi0	306	41	[	[	-LRB-
cord-002407-25cawzi0	306	42	192	192	CD
cord-002407-25cawzi0	306	43	]	]	-RRB-
cord-002407-25cawzi0	306	44	[	[	-LRB-
cord-002407-25cawzi0	306	45	193	193	CD
cord-002407-25cawzi0	306	46	]	]	-RRB-
cord-002407-25cawzi0	306	47	[	[	-LRB-
cord-002407-25cawzi0	306	48	194	194	CD
cord-002407-25cawzi0	306	49	]	]	-RRB-
cord-002407-25cawzi0	306	50	,	,	,
cord-002407-25cawzi0	306	51	were	be	VBD
cord-002407-25cawzi0	306	52	able	able	JJ
cord-002407-25cawzi0	306	53	to	to	TO
cord-002407-25cawzi0	306	54	induced	induced	VB
cord-002407-25cawzi0	306	55	Abs	Abs	NNP
cord-002407-25cawzi0	306	56	against	against	IN
cord-002407-25cawzi0	306	57	the	the	DT
cord-002407-25cawzi0	306	58	foreign	foreign	JJ
cord-002407-25cawzi0	306	59	polypeptides	polypeptide	NNS
cord-002407-25cawzi0	306	60	and	and	CC
cord-002407-25cawzi0	306	61	reduced	reduce	VBD
cord-002407-25cawzi0	306	62	the	the	DT
cord-002407-25cawzi0	306	63	viral	viral	JJ
cord-002407-25cawzi0	306	64	load	load	NN
cord-002407-25cawzi0	306	65	of	of	IN
cord-002407-25cawzi0	306	66	the	the	DT
cord-002407-25cawzi0	306	67	heterologous	heterologous	JJ
cord-002407-25cawzi0	306	68	pathogen	pathogen	NN
cord-002407-25cawzi0	306	69	while	while	IN
cord-002407-25cawzi0	306	70	retaining	retain	VBG
cord-002407-25cawzi0	306	71	their	-PRON-	PRP$
cord-002407-25cawzi0	306	72	ability	ability	NN
cord-002407-25cawzi0	306	73	to	to	TO
cord-002407-25cawzi0	306	74	protect	protect	VB
cord-002407-25cawzi0	306	75	against	against	IN
cord-002407-25cawzi0	306	76	challenge	challenge	NN
cord-002407-25cawzi0	306	77	with	with	IN
cord-002407-25cawzi0	306	78	IAV	IAV	NNP
cord-002407-25cawzi0	306	79	.	.	.
cord-002407-25cawzi0	307	1	It	-PRON-	PRP
cord-002407-25cawzi0	307	2	is	be	VBZ
cord-002407-25cawzi0	307	3	worth	worth	JJ
cord-002407-25cawzi0	307	4	indicating	indicate	VBG
cord-002407-25cawzi0	307	5	that	that	IN
cord-002407-25cawzi0	307	6	,	,	,
cord-002407-25cawzi0	307	7	for	for	IN
cord-002407-25cawzi0	307	8	vaccine	vaccine	NN
cord-002407-25cawzi0	307	9	purposes	purpose	NNS
cord-002407-25cawzi0	307	10	,	,	,
cord-002407-25cawzi0	307	11	it	-PRON-	PRP
cord-002407-25cawzi0	307	12	is	be	VBZ
cord-002407-25cawzi0	307	13	important	important	JJ
cord-002407-25cawzi0	307	14	to	to	TO
cord-002407-25cawzi0	307	15	consider	consider	VB
cord-002407-25cawzi0	307	16	what	what	WP
cord-002407-25cawzi0	307	17	influenza	influenza	NN
cord-002407-25cawzi0	307	18	viral	viral	JJ
cord-002407-25cawzi0	307	19	gene	gene	NN
cord-002407-25cawzi0	307	20	is	be	VBZ
cord-002407-25cawzi0	307	21	replaced	replace	VBN
cord-002407-25cawzi0	307	22	,	,	,
cord-002407-25cawzi0	307	23	since	since	IN
cord-002407-25cawzi0	307	24	it	-PRON-	PRP
cord-002407-25cawzi0	307	25	was	be	VBD
cord-002407-25cawzi0	307	26	shown	show	VBN
cord-002407-25cawzi0	307	27	that	that	IN
cord-002407-25cawzi0	307	28	sciIAV	sciIAV	VBZ
cord-002407-25cawzi0	307	29	replication	replication	NN
cord-002407-25cawzi0	307	30	is	be	VBZ
cord-002407-25cawzi0	307	31	required	require	VBN
cord-002407-25cawzi0	307	32	for	for	IN
cord-002407-25cawzi0	307	33	protection	protection	NN
cord-002407-25cawzi0	307	34	[	[	-LRB-
cord-002407-25cawzi0	307	35	69	69	CD
cord-002407-25cawzi0	307	36	,	,	,
cord-002407-25cawzi0	307	37	185	185	CD
cord-002407-25cawzi0	307	38	,	,	,
cord-002407-25cawzi0	307	39	189	189	CD
cord-002407-25cawzi0	307	40	]	]	-RRB-
cord-002407-25cawzi0	307	41	.	.	.
cord-002407-25cawzi0	308	1	Although	although	IN
cord-002407-25cawzi0	308	2	substitution	substitution	NN
cord-002407-25cawzi0	308	3	of	of	IN
cord-002407-25cawzi0	308	4	the	the	DT
cord-002407-25cawzi0	308	5	polymerase	polymerase	NN
cord-002407-25cawzi0	308	6	(	(	-LRB-
cord-002407-25cawzi0	308	7	PB2	PB2	NNP
cord-002407-25cawzi0	308	8	,	,	,
cord-002407-25cawzi0	308	9	PB1	PB1	NNP
cord-002407-25cawzi0	308	10	and	and	CC
cord-002407-25cawzi0	308	11	PA	PA	NNP
cord-002407-25cawzi0	308	12	)	)	-RRB-
cord-002407-25cawzi0	308	13	segments	segment	NNS
cord-002407-25cawzi0	308	14	may	may	MD
cord-002407-25cawzi0	308	15	allow	allow	VB
cord-002407-25cawzi0	308	16	insertion	insertion	NN
cord-002407-25cawzi0	308	17	of	of	IN
cord-002407-25cawzi0	308	18	larger	large	JJR
cord-002407-25cawzi0	308	19	foreign	foreign	JJ
cord-002407-25cawzi0	308	20	genes	gene	NNS
cord-002407-25cawzi0	308	21	,	,	,
cord-002407-25cawzi0	308	22	removing	remove	VBG
cord-002407-25cawzi0	308	23	the	the	DT
cord-002407-25cawzi0	308	24	viral	viral	JJ
cord-002407-25cawzi0	308	25	polymerase	polymerase	NN
cord-002407-25cawzi0	308	26	from	from	IN
cord-002407-25cawzi0	308	27	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	308	28	limits	limit	VBZ
cord-002407-25cawzi0	308	29	their	-PRON-	PRP$
cord-002407-25cawzi0	308	30	ability	ability	NN
cord-002407-25cawzi0	308	31	to	to	TO
cord-002407-25cawzi0	308	32	express	express	VB
cord-002407-25cawzi0	308	33	more	more	JJR
cord-002407-25cawzi0	308	34	polymerase	polymerase	NN
cord-002407-25cawzi0	308	35	during	during	IN
cord-002407-25cawzi0	308	36	the	the	DT
cord-002407-25cawzi0	308	37	single	single	JJ
cord-002407-25cawzi0	308	38	-	-	HYPH
cord-002407-25cawzi0	308	39	cycle	cycle	NN
cord-002407-25cawzi0	308	40	round	round	NN
cord-002407-25cawzi0	308	41	of	of	IN
cord-002407-25cawzi0	308	42	infection	infection	NN
cord-002407-25cawzi0	308	43	,	,	,
cord-002407-25cawzi0	308	44	decreasing	decrease	VBG
cord-002407-25cawzi0	308	45	total	total	JJ
cord-002407-25cawzi0	308	46	viral	viral	JJ
cord-002407-25cawzi0	308	47	antigens	antigen	NNS
cord-002407-25cawzi0	308	48	and	and	CC
cord-002407-25cawzi0	308	49	,	,	,
cord-002407-25cawzi0	308	50	thus	thus	RB
cord-002407-25cawzi0	308	51	,	,	,
cord-002407-25cawzi0	308	52	limiting	limit	VBG
cord-002407-25cawzi0	308	53	their	-PRON-	PRP$
cord-002407-25cawzi0	308	54	protective	protective	JJ
cord-002407-25cawzi0	308	55	efficacy	efficacy	NN
cord-002407-25cawzi0	308	56	.	.	.
cord-002407-25cawzi0	309	1	Thus	thus	RB
cord-002407-25cawzi0	309	2	,	,	,
cord-002407-25cawzi0	309	3	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	309	4	where	where	WRB
cord-002407-25cawzi0	309	5	the	the	DT
cord-002407-25cawzi0	309	6	viral	viral	JJ
cord-002407-25cawzi0	309	7	HA	HA	NNP
cord-002407-25cawzi0	309	8	or	or	CC
cord-002407-25cawzi0	309	9	NA	NA	NNP
cord-002407-25cawzi0	309	10	has	have	VBZ
cord-002407-25cawzi0	309	11	been	be	VBN
cord-002407-25cawzi0	309	12	removed	remove	VBN
cord-002407-25cawzi0	309	13	were	be	VBD
cord-002407-25cawzi0	309	14	able	able	JJ
cord-002407-25cawzi0	309	15	to	to	TO
cord-002407-25cawzi0	309	16	confer	confer	VB
cord-002407-25cawzi0	309	17	,	,	,
cord-002407-25cawzi0	309	18	upon	upon	IN
cord-002407-25cawzi0	309	19	a	a	DT
cord-002407-25cawzi0	309	20	single	single	JJ
cord-002407-25cawzi0	309	21	immunization	immunization	NN
cord-002407-25cawzi0	309	22	,	,	,
cord-002407-25cawzi0	309	23	protection	protection	NN
cord-002407-25cawzi0	309	24	against	against	IN
cord-002407-25cawzi0	309	25	a	a	DT
cord-002407-25cawzi0	309	26	lethal	lethal	JJ
cord-002407-25cawzi0	309	27	challenge	challenge	NN
cord-002407-25cawzi0	309	28	with	with	IN
cord-002407-25cawzi0	309	29	influenza	influenza	NN
cord-002407-25cawzi0	309	30	.	.	.
cord-002407-25cawzi0	310	1	[	[	-LRB-
cord-002407-25cawzi0	310	2	190	190	CD
cord-002407-25cawzi0	310	3	]	]	-RRB-
cord-002407-25cawzi0	310	4	.	.	.
cord-002407-25cawzi0	311	1	On	on	IN
cord-002407-25cawzi0	311	2	the	the	DT
cord-002407-25cawzi0	311	3	contrary	contrary	NN
cord-002407-25cawzi0	311	4	,	,	,
cord-002407-25cawzi0	311	5	a	a	DT
cord-002407-25cawzi0	311	6	single	single	JJ
cord-002407-25cawzi0	311	7	dose	dose	NN
cord-002407-25cawzi0	311	8	of	of	IN
cord-002407-25cawzi0	311	9	a	a	DT
cord-002407-25cawzi0	311	10	sciIAV	sciIAV	NNS
cord-002407-25cawzi0	311	11	where	where	WRB
cord-002407-25cawzi0	311	12	the	the	DT
cord-002407-25cawzi0	311	13	viral	viral	JJ
cord-002407-25cawzi0	311	14	PB2	PB2	NNP
cord-002407-25cawzi0	311	15	has	have	VBZ
cord-002407-25cawzi0	311	16	been	be	VBN
cord-002407-25cawzi0	311	17	removed	remove	VBN
cord-002407-25cawzi0	311	18	was	be	VBD
cord-002407-25cawzi0	311	19	only	only	RB
cord-002407-25cawzi0	311	20	as	as	RB
cord-002407-25cawzi0	311	21	efficacious	efficacious	JJ
cord-002407-25cawzi0	311	22	as	as	IN
cord-002407-25cawzi0	311	23	an	an	DT
cord-002407-25cawzi0	311	24	inactivated	inactivate	VBN
cord-002407-25cawzi0	311	25	virus	virus	NN
cord-002407-25cawzi0	311	26	[	[	-LRB-
cord-002407-25cawzi0	311	27	189	189	CD
cord-002407-25cawzi0	311	28	]	]	-RRB-
cord-002407-25cawzi0	311	29	.	.	.
cord-002407-25cawzi0	312	1	It	-PRON-	PRP
cord-002407-25cawzi0	312	2	is	be	VBZ
cord-002407-25cawzi0	312	3	worth	worth	JJ
cord-002407-25cawzi0	312	4	noting	note	VBG
cord-002407-25cawzi0	312	5	that	that	IN
cord-002407-25cawzi0	312	6	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	312	7	combine	combine	VBP
cord-002407-25cawzi0	312	8	the	the	DT
cord-002407-25cawzi0	312	9	advantages	advantage	NNS
cord-002407-25cawzi0	312	10	(	(	-LRB-
cord-002407-25cawzi0	312	11	better	well	JJR
cord-002407-25cawzi0	312	12	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	312	13	properties	property	NNS
cord-002407-25cawzi0	312	14	of	of	IN
cord-002407-25cawzi0	312	15	the	the	DT
cord-002407-25cawzi0	312	16	LAIV	LAIV	NNP
cord-002407-25cawzi0	312	17	and	and	CC
cord-002407-25cawzi0	312	18	the	the	DT
cord-002407-25cawzi0	312	19	safety	safety	NN
cord-002407-25cawzi0	312	20	profile	profile	NN
cord-002407-25cawzi0	312	21	of	of	IN
cord-002407-25cawzi0	312	22	the	the	DT
cord-002407-25cawzi0	312	23	IIV	IIV	NNP
cord-002407-25cawzi0	312	24	)	)	-RRB-
cord-002407-25cawzi0	312	25	and	and	CC
cord-002407-25cawzi0	312	26	circumvent	circumvent	VB
cord-002407-25cawzi0	312	27	the	the	DT
cord-002407-25cawzi0	312	28	disadvantages	disadvantage	NNS
cord-002407-25cawzi0	312	29	(	(	-LRB-
cord-002407-25cawzi0	312	30	safety	safety	NN
cord-002407-25cawzi0	312	31	of	of	IN
cord-002407-25cawzi0	312	32	the	the	DT
cord-002407-25cawzi0	312	33	LAIV	LAIV	NNP
cord-002407-25cawzi0	312	34	and	and	CC
cord-002407-25cawzi0	312	35	poor	poor	JJ
cord-002407-25cawzi0	312	36	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	312	37	of	of	IN
cord-002407-25cawzi0	312	38	the	the	DT
cord-002407-25cawzi0	312	39	IIV	IIV	NNP
cord-002407-25cawzi0	312	40	)	)	-RRB-
cord-002407-25cawzi0	312	41	of	of	IN
cord-002407-25cawzi0	312	42	current	current	JJ
cord-002407-25cawzi0	312	43	influenza	influenza	NN
cord-002407-25cawzi0	312	44	vaccine	vaccine	NN
cord-002407-25cawzi0	312	45	approaches	approach	VBZ
cord-002407-25cawzi0	312	46	[	[	-LRB-
cord-002407-25cawzi0	312	47	144	144	CD
cord-002407-25cawzi0	312	48	]	]	-RRB-
cord-002407-25cawzi0	312	49	.	.	.
cord-002407-25cawzi0	313	1	While	while	IN
cord-002407-25cawzi0	313	2	sciIAVs	sciIAVs	NNP
cord-002407-25cawzi0	313	3	have	have	VBP
cord-002407-25cawzi0	313	4	been	be	VBN
cord-002407-25cawzi0	313	5	shown	show	VBN
cord-002407-25cawzi0	313	6	to	to	TO
cord-002407-25cawzi0	313	7	be	be	VB
cord-002407-25cawzi0	313	8	safe	safe	JJ
cord-002407-25cawzi0	313	9	,	,	,
cord-002407-25cawzi0	313	10	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	313	11	and	and	CC
cord-002407-25cawzi0	313	12	protective	protective	JJ
cord-002407-25cawzi0	313	13	against	against	IN
cord-002407-25cawzi0	313	14	lethal	lethal	JJ
cord-002407-25cawzi0	313	15	challenges	challenge	NNS
cord-002407-25cawzi0	313	16	with	with	IN
cord-002407-25cawzi0	313	17	wild	wild	JJ
cord-002407-25cawzi0	313	18	-	-	HYPH
cord-002407-25cawzi0	313	19	type	type	NN
cord-002407-25cawzi0	313	20	forms	form	NNS
cord-002407-25cawzi0	313	21	of	of	IN
cord-002407-25cawzi0	313	22	IAVs	iav	NNS
cord-002407-25cawzi0	313	23	in	in	IN
cord-002407-25cawzi0	313	24	animal	animal	NN
cord-002407-25cawzi0	313	25	studies	study	NNS
cord-002407-25cawzi0	313	26	,	,	,
cord-002407-25cawzi0	313	27	no	no	DT
cord-002407-25cawzi0	313	28	human	human	JJ
cord-002407-25cawzi0	313	29	trials	trial	NNS
cord-002407-25cawzi0	313	30	have	have	VBP
cord-002407-25cawzi0	313	31	yet	yet	RB
cord-002407-25cawzi0	313	32	been	be	VBN
cord-002407-25cawzi0	313	33	performed	perform	VBN
cord-002407-25cawzi0	313	34	.	.	.
cord-002407-25cawzi0	314	1	More	more	RBR
cord-002407-25cawzi0	314	2	recently	recently	RB
cord-002407-25cawzi0	314	3	,	,	,
cord-002407-25cawzi0	314	4	the	the	DT
cord-002407-25cawzi0	314	5	rearrangement	rearrangement	NN
cord-002407-25cawzi0	314	6	of	of	IN
cord-002407-25cawzi0	314	7	the	the	DT
cord-002407-25cawzi0	314	8	influenza	influenza	NN
cord-002407-25cawzi0	314	9	virus	virus	NN
cord-002407-25cawzi0	314	10	genome	genome	NN
cord-002407-25cawzi0	314	11	has	have	VBZ
cord-002407-25cawzi0	314	12	been	be	VBN
cord-002407-25cawzi0	314	13	shown	show	VBN
cord-002407-25cawzi0	314	14	to	to	TO
cord-002407-25cawzi0	314	15	have	have	VB
cord-002407-25cawzi0	314	16	great	great	JJ
cord-002407-25cawzi0	314	17	potential	potential	NN
cord-002407-25cawzi0	314	18	for	for	IN
cord-002407-25cawzi0	314	19	the	the	DT
cord-002407-25cawzi0	314	20	development	development	NN
cord-002407-25cawzi0	314	21	of	of	IN
cord-002407-25cawzi0	314	22	improved	improved	JJ
cord-002407-25cawzi0	314	23	LAIVs	laiv	NNS
cord-002407-25cawzi0	314	24	against	against	IN
cord-002407-25cawzi0	314	25	influenza	influenza	NN
cord-002407-25cawzi0	314	26	virus	virus	NN
cord-002407-25cawzi0	314	27	,	,	,
cord-002407-25cawzi0	314	28	as	as	RB
cord-002407-25cawzi0	314	29	well	well	RB
cord-002407-25cawzi0	314	30	as	as	IN
cord-002407-25cawzi0	314	31	vaccine	vaccine	NN
cord-002407-25cawzi0	314	32	vectors	vector	NNS
cord-002407-25cawzi0	314	33	against	against	IN
cord-002407-25cawzi0	314	34	other	other	JJ
cord-002407-25cawzi0	314	35	pathogens	pathogen	NNS
cord-002407-25cawzi0	314	36	[	[	-LRB-
cord-002407-25cawzi0	314	37	195	195	CD
cord-002407-25cawzi0	314	38	,	,	,
cord-002407-25cawzi0	314	39	196	196	CD
cord-002407-25cawzi0	314	40	]	]	-RRB-
cord-002407-25cawzi0	314	41	.	.	.
cord-002407-25cawzi0	315	1	Avian	avian	JJ
cord-002407-25cawzi0	315	2	influenza	influenza	NN
cord-002407-25cawzi0	315	3	virus	virus	NN
cord-002407-25cawzi0	315	4	subtypes	subtype	NNS
cord-002407-25cawzi0	315	5	H5N1	H5N1	NNP
cord-002407-25cawzi0	315	6	and	and	CC
cord-002407-25cawzi0	315	7	H9N2	H9N2	NNP
cord-002407-25cawzi0	315	8	have	have	VBP
cord-002407-25cawzi0	315	9	pandemic	pandemic	NN
cord-002407-25cawzi0	315	10	potential	potential	JJ
cord-002407-25cawzi0	315	11	[	[	-LRB-
cord-002407-25cawzi0	315	12	197	197	CD
cord-002407-25cawzi0	315	13	,	,	,
cord-002407-25cawzi0	315	14	198	198	CD
cord-002407-25cawzi0	315	15	]	]	-RRB-
cord-002407-25cawzi0	315	16	.	.	.
cord-002407-25cawzi0	316	1	However	however	RB
cord-002407-25cawzi0	316	2	,	,	,
cord-002407-25cawzi0	316	3	H5N1	H5N1	NNP
cord-002407-25cawzi0	316	4	IIV	IIV	NNP
cord-002407-25cawzi0	316	5	induces	induce	VBZ
cord-002407-25cawzi0	316	6	limited	limited	JJ
cord-002407-25cawzi0	316	7	adaptive	adaptive	JJ
cord-002407-25cawzi0	316	8	immune	immune	JJ
cord-002407-25cawzi0	316	9	responses	response	NNS
cord-002407-25cawzi0	316	10	,	,	,
cord-002407-25cawzi0	316	11	and	and	CC
cord-002407-25cawzi0	316	12	in	in	IN
cord-002407-25cawzi0	316	13	the	the	DT
cord-002407-25cawzi0	316	14	case	case	NN
cord-002407-25cawzi0	316	15	of	of	IN
cord-002407-25cawzi0	316	16	LAIV	LAIV	NNP
cord-002407-25cawzi0	316	17	,	,	,
cord-002407-25cawzi0	316	18	there	there	EX
cord-002407-25cawzi0	316	19	are	be	VBP
cord-002407-25cawzi0	316	20	safety	safety	NN
cord-002407-25cawzi0	316	21	concerns	concern	NNS
cord-002407-25cawzi0	316	22	about	about	IN
cord-002407-25cawzi0	316	23	the	the	DT
cord-002407-25cawzi0	316	24	possibility	possibility	NN
cord-002407-25cawzi0	316	25	of	of	IN
cord-002407-25cawzi0	316	26	reassortment	reassortment	NN
cord-002407-25cawzi0	316	27	between	between	IN
cord-002407-25cawzi0	316	28	the	the	DT
cord-002407-25cawzi0	316	29	viral	viral	JJ
cord-002407-25cawzi0	316	30	segments	segment	NNS
cord-002407-25cawzi0	316	31	in	in	IN
cord-002407-25cawzi0	316	32	the	the	DT
cord-002407-25cawzi0	316	33	LAIV	LAIV	NNP
cord-002407-25cawzi0	316	34	and	and	CC
cord-002407-25cawzi0	316	35	circulating	circulate	VBG
cord-002407-25cawzi0	316	36	H5N1	H5N1	NNP
cord-002407-25cawzi0	316	37	strains	strain	NNS
cord-002407-25cawzi0	316	38	.	.	.
cord-002407-25cawzi0	317	1	To	to	TO
cord-002407-25cawzi0	317	2	overcome	overcome	VB
cord-002407-25cawzi0	317	3	these	these	DT
cord-002407-25cawzi0	317	4	concerns	concern	NNS
cord-002407-25cawzi0	317	5	,	,	,
cord-002407-25cawzi0	317	6	a	a	DT
cord-002407-25cawzi0	317	7	bivalent	bivalent	JJ
cord-002407-25cawzi0	317	8	LAIV	LAIV	NNP
cord-002407-25cawzi0	317	9	against	against	IN
cord-002407-25cawzi0	317	10	influenza	influenza	NN
cord-002407-25cawzi0	317	11	A	a	NN
cord-002407-25cawzi0	318	1	/Vietnam/120320/04	/Vietnam/120320/04	:
cord-002407-25cawzi0	318	2	H5N1	H5N1	NNP
cord-002407-25cawzi0	318	3	and	and	CC
cord-002407-25cawzi0	318	4	A	A	NNP
cord-002407-25cawzi0	318	5	/	/	SYM
cord-002407-25cawzi0	318	6	Guinea	Guinea	NNP
cord-002407-25cawzi0	318	7	fowl/	fowl/	NNP
cord-002407-25cawzi0	319	1	Hong	Hong	NNP
cord-002407-25cawzi0	319	2	Kong	Kong	NNP
cord-002407-25cawzi0	319	3	/	/	SYM
cord-002407-25cawzi0	319	4	WF10/1999	WF10/1999	NNP
cord-002407-25cawzi0	319	5	H9N2	H9N2	NNP
cord-002407-25cawzi0	319	6	was	be	VBD
cord-002407-25cawzi0	319	7	generated	generate	VBN
cord-002407-25cawzi0	319	8	using	use	VBG
cord-002407-25cawzi0	319	9	viral	viral	JJ
cord-002407-25cawzi0	319	10	genome	genome	NN
cord-002407-25cawzi0	319	11	rearrangement	rearrangement	NN
cord-002407-25cawzi0	319	12	[	[	-LRB-
cord-002407-25cawzi0	319	13	195	195	CD
cord-002407-25cawzi0	319	14	]	]	-RRB-
cord-002407-25cawzi0	319	15	.	.	.
cord-002407-25cawzi0	320	1	To	to	IN
cord-002407-25cawzi0	320	2	that	that	DT
cord-002407-25cawzi0	320	3	end	end	NN
cord-002407-25cawzi0	320	4	,	,	,
cord-002407-25cawzi0	320	5	the	the	DT
cord-002407-25cawzi0	320	6	NEP	nep	NN
cord-002407-25cawzi0	320	7	was	be	VBD
cord-002407-25cawzi0	320	8	removed	remove	VBN
cord-002407-25cawzi0	320	9	from	from	IN
cord-002407-25cawzi0	320	10	the	the	DT
cord-002407-25cawzi0	320	11	NS	NS	NNP
cord-002407-25cawzi0	320	12	viral	viral	JJ
cord-002407-25cawzi0	320	13	segment	segment	NN
cord-002407-25cawzi0	320	14	of	of	IN
cord-002407-25cawzi0	320	15	the	the	DT
cord-002407-25cawzi0	320	16	H9N2	H9N2	NNP
cord-002407-25cawzi0	320	17	virus	virus	NN
cord-002407-25cawzi0	320	18	and	and	CC
cord-002407-25cawzi0	320	19	substituted	substitute	VBN
cord-002407-25cawzi0	320	20	by	by	IN
cord-002407-25cawzi0	320	21	the	the	DT
cord-002407-25cawzi0	320	22	HA	HA	NNP
cord-002407-25cawzi0	320	23	of	of	IN
cord-002407-25cawzi0	320	24	the	the	DT
cord-002407-25cawzi0	320	25	H5N1	H5N1	NNP
cord-002407-25cawzi0	320	26	virus	virus	NN
cord-002407-25cawzi0	320	27	.	.	.
cord-002407-25cawzi0	321	1	H9N2	H9N2	NNP
cord-002407-25cawzi0	321	2	NS1	NS1	NNP
cord-002407-25cawzi0	321	3	and	and	CC
cord-002407-25cawzi0	321	4	H5N1	H5N1	NNP
cord-002407-25cawzi0	321	5	HA	HA	NNP
cord-002407-25cawzi0	321	6	were	be	VBD
cord-002407-25cawzi0	321	7	separated	separate	VBN
cord-002407-25cawzi0	321	8	by	by	IN
cord-002407-25cawzi0	321	9	the	the	DT
cord-002407-25cawzi0	321	10	foot	foot	NN
cord-002407-25cawzi0	321	11	-	-	HYPH
cord-002407-25cawzi0	321	12	and	and	CC
cord-002407-25cawzi0	321	13	-	-	HYPH
cord-002407-25cawzi0	321	14	mouth	mouth	NN
cord-002407-25cawzi0	321	15	disease	disease	NN
cord-002407-25cawzi0	321	16	virus	virus	NN
cord-002407-25cawzi0	321	17	(	(	-LRB-
cord-002407-25cawzi0	321	18	FMDV	FMDV	NNP
cord-002407-25cawzi0	321	19	)	)	-RRB-
cord-002407-25cawzi0	322	1	2A	2A	NNP
cord-002407-25cawzi0	322	2	autocleavage	autocleavage	NNP
cord-002407-25cawzi0	322	3	site	site	NN
cord-002407-25cawzi0	322	4	to	to	TO
cord-002407-25cawzi0	322	5	allow	allow	VB
cord-002407-25cawzi0	322	6	co	co	JJ
cord-002407-25cawzi0	322	7	-	-	JJ
cord-002407-25cawzi0	322	8	linear	linear	JJ
cord-002407-25cawzi0	322	9	expression	expression	NN
cord-002407-25cawzi0	322	10	of	of	IN
cord-002407-25cawzi0	322	11	both	both	DT
cord-002407-25cawzi0	322	12	viral	viral	JJ
cord-002407-25cawzi0	322	13	proteins	protein	NNS
cord-002407-25cawzi0	322	14	.	.	.
cord-002407-25cawzi0	323	1	Then	then	RB
cord-002407-25cawzi0	323	2	,	,	,
cord-002407-25cawzi0	323	3	NEP	NEP	NNP
cord-002407-25cawzi0	323	4	was	be	VBD
cord-002407-25cawzi0	323	5	cloned	clone	VBN
cord-002407-25cawzi0	323	6	down	down	IN
cord-002407-25cawzi0	323	7	-	-	HYPH
cord-002407-25cawzi0	323	8	strain	strain	NN
cord-002407-25cawzi0	323	9	of	of	IN
cord-002407-25cawzi0	323	10	the	the	DT
cord-002407-25cawzi0	323	11	H9N2	H9N2	NNP
cord-002407-25cawzi0	323	12	PB1	pb1	NN
cord-002407-25cawzi0	323	13	segment	segment	NN
cord-002407-25cawzi0	323	14	separated	separate	VBN
cord-002407-25cawzi0	323	15	by	by	IN
cord-002407-25cawzi0	323	16	another	another	DT
cord-002407-25cawzi0	323	17	FMDV	FMDV	NNP
cord-002407-25cawzi0	323	18	2A	2a	CD
cord-002407-25cawzi0	323	19	autocleavage	autocleavage	NN
cord-002407-25cawzi0	323	20	site	site	NN
cord-002407-25cawzi0	323	21	.	.	.
cord-002407-25cawzi0	324	1	The	the	DT
cord-002407-25cawzi0	324	2	rearranged	rearrange	VBN
cord-002407-25cawzi0	324	3	H9N2	H9N2	NNP
cord-002407-25cawzi0	324	4	virus	virus	NN
cord-002407-25cawzi0	324	5	expressing	express	VBG
cord-002407-25cawzi0	324	6	the	the	DT
cord-002407-25cawzi0	324	7	H5N1	H5N1	NNP
cord-002407-25cawzi0	324	8	HA	HA	NNP
cord-002407-25cawzi0	324	9	was	be	VBD
cord-002407-25cawzi0	324	10	able	able	JJ
cord-002407-25cawzi0	324	11	to	to	TO
cord-002407-25cawzi0	324	12	provide	provide	VB
cord-002407-25cawzi0	324	13	complete	complete	JJ
cord-002407-25cawzi0	324	14	protection	protection	NN
cord-002407-25cawzi0	324	15	against	against	IN
cord-002407-25cawzi0	324	16	challenge	challenge	NN
cord-002407-25cawzi0	324	17	with	with	IN
cord-002407-25cawzi0	324	18	A	A	NNP
cord-002407-25cawzi0	324	19	/	/	SYM
cord-002407-25cawzi0	324	20	Vietnam/1203/2004	Vietnam/1203/2004	NNP
cord-002407-25cawzi0	324	21	H5N1	H5N1	NNP
cord-002407-25cawzi0	324	22	and	and	CC
cord-002407-25cawzi0	324	23	also	also	RB
cord-002407-25cawzi0	324	24	against	against	IN
cord-002407-25cawzi0	324	25	a	a	DT
cord-002407-25cawzi0	324	26	potential	potential	JJ
cord-002407-25cawzi0	324	27	pandemic	pandemic	NN
cord-002407-25cawzi0	324	28	H9	h9	NN
cord-002407-25cawzi0	324	29	:	:	:
cord-002407-25cawzi0	325	1	pH1N1	pH1N1	NNP
cord-002407-25cawzi0	326	1	IAV	IAV	NNP
cord-002407-25cawzi0	326	2	reassortant	reassortant	JJ
cord-002407-25cawzi0	326	3	virus	virus	NN
cord-002407-25cawzi0	326	4	in	in	IN
cord-002407-25cawzi0	326	5	both	both	DT
cord-002407-25cawzi0	326	6	mice	mouse	NNS
cord-002407-25cawzi0	326	7	and	and	CC
cord-002407-25cawzi0	326	8	ferrets	ferret	NNS
cord-002407-25cawzi0	326	9	[	[	-LRB-
cord-002407-25cawzi0	326	10	195	195	CD
cord-002407-25cawzi0	326	11	]	]	-RRB-
cord-002407-25cawzi0	326	12	.	.	.
cord-002407-25cawzi0	327	1	Segments	segment	NNS
cord-002407-25cawzi0	327	2	7	7	CD
cord-002407-25cawzi0	327	3	(	(	-LRB-
cord-002407-25cawzi0	327	4	M	M	NNP
cord-002407-25cawzi0	327	5	)	)	-RRB-
cord-002407-25cawzi0	327	6	and	and	CC
cord-002407-25cawzi0	327	7	8	8	CD
cord-002407-25cawzi0	327	8	(	(	-LRB-
cord-002407-25cawzi0	327	9	NS	NS	NNP
cord-002407-25cawzi0	327	10	)	)	-RRB-
cord-002407-25cawzi0	327	11	of	of	IN
cord-002407-25cawzi0	327	12	IAVs	iav	NNS
cord-002407-25cawzi0	327	13	use	use	VBP
cord-002407-25cawzi0	327	14	an	an	DT
cord-002407-25cawzi0	327	15	alternative	alternative	JJ
cord-002407-25cawzi0	327	16	splicing	splicing	NN
cord-002407-25cawzi0	327	17	mechanism	mechanism	NN
cord-002407-25cawzi0	327	18	to	to	TO
cord-002407-25cawzi0	327	19	express	express	VB
cord-002407-25cawzi0	327	20	two	two	CD
cord-002407-25cawzi0	327	21	different	different	JJ
cord-002407-25cawzi0	327	22	viral	viral	JJ
cord-002407-25cawzi0	327	23	proteins	protein	NNS
cord-002407-25cawzi0	327	24	from	from	IN
cord-002407-25cawzi0	327	25	the	the	DT
cord-002407-25cawzi0	327	26	same	same	JJ
cord-002407-25cawzi0	327	27	viral	viral	JJ
cord-002407-25cawzi0	327	28	segment	segment	NN
cord-002407-25cawzi0	327	29	.	.	.
cord-002407-25cawzi0	328	1	Recently	recently	RB
cord-002407-25cawzi0	328	2	,	,	,
cord-002407-25cawzi0	328	3	we	-PRON-	PRP
cord-002407-25cawzi0	328	4	have	have	VBP
cord-002407-25cawzi0	328	5	generated	generate	VBN
cord-002407-25cawzi0	328	6	recombinant	recombinant	JJ
cord-002407-25cawzi0	328	7	influenza	influenza	NN
cord-002407-25cawzi0	328	8	A	A	NNP
cord-002407-25cawzi0	328	9	/	/	SYM
cord-002407-25cawzi0	328	10	Puerto	Puerto	NNP
cord-002407-25cawzi0	328	11	Rico/8/34	Rico/8/34	NNP
cord-002407-25cawzi0	328	12	H1N1	H1N1	NNP
cord-002407-25cawzi0	328	13	viruses	virus	NNS
cord-002407-25cawzi0	328	14	containing	contain	VBG
cord-002407-25cawzi0	328	15	modified	modify	VBN
cord-002407-25cawzi0	328	16	M	M	NNP
cord-002407-25cawzi0	328	17	and/or	and/or	CC
cord-002407-25cawzi0	328	18	NS	NS	NNP
cord-002407-25cawzi0	328	19	segments	segment	NNS
cord-002407-25cawzi0	328	20	,	,	,
cord-002407-25cawzi0	329	1	in	in	IN
cord-002407-25cawzi0	329	2	which	which	WDT
cord-002407-25cawzi0	329	3	the	the	DT
cord-002407-25cawzi0	329	4	overlapping	overlap	VBG
cord-002407-25cawzi0	329	5	ORFs	orfs	NN
cord-002407-25cawzi0	329	6	of	of	IN
cord-002407-25cawzi0	329	7	the	the	DT
cord-002407-25cawzi0	329	8	M1	M1	NNP
cord-002407-25cawzi0	329	9	and	and	CC
cord-002407-25cawzi0	329	10	M2	M2	NNP
cord-002407-25cawzi0	329	11	viral	viral	JJ
cord-002407-25cawzi0	329	12	proteins	protein	NNS
cord-002407-25cawzi0	329	13	(	(	-LRB-
cord-002407-25cawzi0	329	14	M	M	NNP
cord-002407-25cawzi0	329	15	segment	segment	NN
cord-002407-25cawzi0	329	16	)	)	-RRB-
cord-002407-25cawzi0	329	17	and/or	and/or	CC
cord-002407-25cawzi0	329	18	the	the	DT
cord-002407-25cawzi0	329	19	NS1	ns1	NN
cord-002407-25cawzi0	329	20	and	and	CC
cord-002407-25cawzi0	329	21	NEP	nep	NN
cord-002407-25cawzi0	329	22	proteins	protein	NNS
cord-002407-25cawzi0	330	1	(	(	-LRB-
cord-002407-25cawzi0	330	2	NS	NS	NNP
cord-002407-25cawzi0	330	3	segment	segment	NN
cord-002407-25cawzi0	330	4	)	)	-RRB-
cord-002407-25cawzi0	330	5	were	be	VBD
cord-002407-25cawzi0	330	6	separated	separate	VBN
cord-002407-25cawzi0	330	7	with	with	IN
cord-002407-25cawzi0	330	8	the	the	DT
cord-002407-25cawzi0	330	9	porcine	porcine	JJ
cord-002407-25cawzi0	330	10	teschovirus	teschovirus	NNP
cord-002407-25cawzi0	330	11	1	1	CD
cord-002407-25cawzi0	330	12	(	(	-LRB-
cord-002407-25cawzi0	330	13	PTV-1	PTV-1	NNP
cord-002407-25cawzi0	330	14	)	)	-RRB-
cord-002407-25cawzi0	330	15	2A	2a	CD
cord-002407-25cawzi0	330	16	autocleavage	autocleavage	NN
cord-002407-25cawzi0	330	17	site	site	NN
cord-002407-25cawzi0	330	18	[	[	-LRB-
cord-002407-25cawzi0	330	19	196	196	CD
cord-002407-25cawzi0	330	20	]	]	-RRB-
cord-002407-25cawzi0	330	21	.	.	.
cord-002407-25cawzi0	331	1	Recombinant	recombinant	JJ
cord-002407-25cawzi0	331	2	viruses	virus	NNS
cord-002407-25cawzi0	331	3	with	with	IN
cord-002407-25cawzi0	331	4	a	a	DT
cord-002407-25cawzi0	331	5	rearranged	rearrange	VBN
cord-002407-25cawzi0	331	6	M	M	NNP
cord-002407-25cawzi0	331	7	segment	segment	NN
cord-002407-25cawzi0	331	8	were	be	VBD
cord-002407-25cawzi0	331	9	affected	affect	VBN
cord-002407-25cawzi0	331	10	or	or	CC
cord-002407-25cawzi0	331	11	impaired	impair	VBN
cord-002407-25cawzi0	331	12	in	in	IN
cord-002407-25cawzi0	331	13	replication	replication	NN
cord-002407-25cawzi0	331	14	in	in	IN
cord-002407-25cawzi0	331	15	vitro	vitro	FW
cord-002407-25cawzi0	331	16	at	at	IN
cord-002407-25cawzi0	331	17	nonpermissive	nonpermissive	JJ
cord-002407-25cawzi0	331	18	temperatures	temperature	NNS
cord-002407-25cawzi0	331	19	(	(	-LRB-
cord-002407-25cawzi0	331	20	37	37	CD
cord-002407-25cawzi0	331	21	and	and	CC
cord-002407-25cawzi0	331	22	39	39	CD
cord-002407-25cawzi0	331	23	•	•	NN
cord-002407-25cawzi0	331	24	C	c	NN
cord-002407-25cawzi0	331	25	,	,	,
cord-002407-25cawzi0	331	26	respectively	respectively	RB
cord-002407-25cawzi0	331	27	)	)	-RRB-
cord-002407-25cawzi0	331	28	,	,	,
cord-002407-25cawzi0	331	29	whereas	whereas	IN
cord-002407-25cawzi0	331	30	high	high	JJ
cord-002407-25cawzi0	331	31	viral	viral	JJ
cord-002407-25cawzi0	331	32	titers	titer	NNS
cord-002407-25cawzi0	331	33	were	be	VBD
cord-002407-25cawzi0	331	34	obtained	obtain	VBN
cord-002407-25cawzi0	331	35	at	at	IN
cord-002407-25cawzi0	331	36	permissive	permissive	JJ
cord-002407-25cawzi0	331	37	low	low	JJ
cord-002407-25cawzi0	331	38	temperatures	temperature	NNS
cord-002407-25cawzi0	331	39	(	(	-LRB-
cord-002407-25cawzi0	331	40	33	33	CD
cord-002407-25cawzi0	331	41	•	•	NN
cord-002407-25cawzi0	331	42	C	c	NN
cord-002407-25cawzi0	331	43	)	)	-RRB-
cord-002407-25cawzi0	332	1	[	[	-LRB-
cord-002407-25cawzi0	332	2	196	196	CD
cord-002407-25cawzi0	332	3	]	]	-RRB-
cord-002407-25cawzi0	332	4	.	.	.
cord-002407-25cawzi0	333	1	Notably	notably	RB
cord-002407-25cawzi0	333	2	,	,	,
cord-002407-25cawzi0	333	3	viruses	virus	NNS
cord-002407-25cawzi0	333	4	containing	contain	VBG
cord-002407-25cawzi0	333	5	the	the	DT
cord-002407-25cawzi0	333	6	M	M	NNP
cord-002407-25cawzi0	333	7	split	split	NN
cord-002407-25cawzi0	333	8	segment	segment	NN
cord-002407-25cawzi0	333	9	were	be	VBD
cord-002407-25cawzi0	333	10	highly	highly	RB
cord-002407-25cawzi0	333	11	attenuated	attenuate	VBN
cord-002407-25cawzi0	333	12	in	in	IN
cord-002407-25cawzi0	333	13	vivo	vivo	NN
cord-002407-25cawzi0	333	14	,	,	,
cord-002407-25cawzi0	333	15	but	but	CC
cord-002407-25cawzi0	333	16	able	able	JJ
cord-002407-25cawzi0	333	17	to	to	TO
cord-002407-25cawzi0	333	18	confer	confer	VB
cord-002407-25cawzi0	333	19	,	,	,
cord-002407-25cawzi0	333	20	upon	upon	IN
cord-002407-25cawzi0	333	21	a	a	DT
cord-002407-25cawzi0	333	22	single	single	JJ
cord-002407-25cawzi0	333	23	immunization	immunization	NN
cord-002407-25cawzi0	333	24	dose	dose	NN
cord-002407-25cawzi0	333	25	,	,	,
cord-002407-25cawzi0	333	26	complete	complete	JJ
cord-002407-25cawzi0	333	27	protection	protection	NN
cord-002407-25cawzi0	333	28	against	against	IN
cord-002407-25cawzi0	333	29	a	a	DT
cord-002407-25cawzi0	333	30	lethal	lethal	JJ
cord-002407-25cawzi0	333	31	homologous	homologous	JJ
cord-002407-25cawzi0	333	32	challenge	challenge	NN
cord-002407-25cawzi0	333	33	with	with	IN
cord-002407-25cawzi0	333	34	wild	wild	JJ
cord-002407-25cawzi0	333	35	-	-	HYPH
cord-002407-25cawzi0	333	36	type	type	NN
cord-002407-25cawzi0	333	37	PR8	pr8	NN
cord-002407-25cawzi0	333	38	[	[	-LRB-
cord-002407-25cawzi0	333	39	196	196	CD
cord-002407-25cawzi0	333	40	]	]	-RRB-
cord-002407-25cawzi0	333	41	.	.	.
cord-002407-25cawzi0	334	1	Importantly	importantly	RB
cord-002407-25cawzi0	334	2	,	,	,
cord-002407-25cawzi0	334	3	viruses	virus	NNS
cord-002407-25cawzi0	334	4	with	with	IN
cord-002407-25cawzi0	334	5	a	a	DT
cord-002407-25cawzi0	334	6	reorganized	reorganize	VBN
cord-002407-25cawzi0	334	7	M	M	NNP
cord-002407-25cawzi0	334	8	segment	segment	NN
cord-002407-25cawzi0	334	9	were	be	VBD
cord-002407-25cawzi0	334	10	able	able	JJ
cord-002407-25cawzi0	334	11	to	to	TO
cord-002407-25cawzi0	334	12	confer	confer	VB
cord-002407-25cawzi0	334	13	better	well	JJR
cord-002407-25cawzi0	334	14	protection	protection	NN
cord-002407-25cawzi0	334	15	than	than	IN
cord-002407-25cawzi0	334	16	a	a	DT
cord-002407-25cawzi0	334	17	temperature	temperature	NN
cord-002407-25cawzi0	334	18	-	-	HYPH
cord-002407-25cawzi0	334	19	sensitive	sensitive	JJ
cord-002407-25cawzi0	334	20	,	,	,
cord-002407-25cawzi0	334	21	LAIV	LAIV	NNP
cord-002407-25cawzi0	334	22	PR8	PR8	NNP
cord-002407-25cawzi0	334	23	virus	virus	NN
cord-002407-25cawzi0	334	24	[	[	-LRB-
cord-002407-25cawzi0	334	25	103	103	CD
cord-002407-25cawzi0	334	26	,	,	,
cord-002407-25cawzi0	334	27	104	104	CD
cord-002407-25cawzi0	334	28	,	,	,
cord-002407-25cawzi0	334	29	115	115	CD
cord-002407-25cawzi0	334	30	,	,	,
cord-002407-25cawzi0	334	31	196	196	CD
cord-002407-25cawzi0	334	32	]	]	-RRB-
cord-002407-25cawzi0	334	33	.	.	.
cord-002407-25cawzi0	335	1	These	these	DT
cord-002407-25cawzi0	335	2	studies	study	NNS
cord-002407-25cawzi0	335	3	demonstrate	demonstrate	VBP
cord-002407-25cawzi0	335	4	that	that	IN
cord-002407-25cawzi0	335	5	the	the	DT
cord-002407-25cawzi0	335	6	rearrangement	rearrangement	NN
cord-002407-25cawzi0	335	7	of	of	IN
cord-002407-25cawzi0	335	8	the	the	DT
cord-002407-25cawzi0	335	9	influenza	influenza	NN
cord-002407-25cawzi0	335	10	viral	viral	JJ
cord-002407-25cawzi0	335	11	genome	genome	NN
cord-002407-25cawzi0	335	12	can	can	MD
cord-002407-25cawzi0	335	13	be	be	VB
cord-002407-25cawzi0	335	14	used	use	VBN
cord-002407-25cawzi0	335	15	for	for	IN
cord-002407-25cawzi0	335	16	the	the	DT
cord-002407-25cawzi0	335	17	generation	generation	NN
cord-002407-25cawzi0	335	18	of	of	IN
cord-002407-25cawzi0	335	19	safe	safe	JJ
cord-002407-25cawzi0	335	20	,	,	,
cord-002407-25cawzi0	335	21	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	335	22	and	and	CC
cord-002407-25cawzi0	335	23	protective	protective	JJ
cord-002407-25cawzi0	335	24	LAIVs	laiv	NNS
cord-002407-25cawzi0	335	25	.	.	.
cord-002407-25cawzi0	336	1	Current	current	JJ
cord-002407-25cawzi0	336	2	influenza	influenza	NN
cord-002407-25cawzi0	336	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	336	4	induce	induce	VBP
cord-002407-25cawzi0	336	5	immunity	immunity	NN
cord-002407-25cawzi0	336	6	to	to	IN
cord-002407-25cawzi0	336	7	the	the	DT
cord-002407-25cawzi0	336	8	influenza	influenza	NN
cord-002407-25cawzi0	336	9	virus	virus	NN
cord-002407-25cawzi0	336	10	strain	strain	NN
cord-002407-25cawzi0	336	11	-	-	HYPH
cord-002407-25cawzi0	336	12	specific	specific	JJ
cord-002407-25cawzi0	336	13	HA	HA	NNP
cord-002407-25cawzi0	336	14	antigen	antigen	NN
cord-002407-25cawzi0	336	15	and	and	CC
cord-002407-25cawzi0	336	16	are	be	VBP
cord-002407-25cawzi0	336	17	not	not	RB
cord-002407-25cawzi0	336	18	very	very	RB
cord-002407-25cawzi0	336	19	effective	effective	JJ
cord-002407-25cawzi0	336	20	against	against	IN
cord-002407-25cawzi0	336	21	new	new	JJ
cord-002407-25cawzi0	336	22	pandemic	pandemic	NN
cord-002407-25cawzi0	336	23	viruses	virus	NNS
cord-002407-25cawzi0	336	24	,	,	,
cord-002407-25cawzi0	336	25	given	give	VBN
cord-002407-25cawzi0	336	26	that	that	IN
cord-002407-25cawzi0	336	27	HA	HA	NNP
cord-002407-25cawzi0	336	28	is	be	VBZ
cord-002407-25cawzi0	336	29	highly	highly	RB
cord-002407-25cawzi0	336	30	susceptible	susceptible	JJ
cord-002407-25cawzi0	336	31	to	to	IN
cord-002407-25cawzi0	336	32	frequent	frequent	JJ
cord-002407-25cawzi0	336	33	changes	change	NNS
cord-002407-25cawzi0	336	34	by	by	IN
cord-002407-25cawzi0	336	35	antigenic	antigenic	JJ
cord-002407-25cawzi0	336	36	drift	drift	NN
cord-002407-25cawzi0	336	37	and	and	CC
cord-002407-25cawzi0	336	38	shift	shift	VB
cord-002407-25cawzi0	336	39	[	[	-LRB-
cord-002407-25cawzi0	336	40	12	12	CD
cord-002407-25cawzi0	336	41	,	,	,
cord-002407-25cawzi0	336	42	[	[	-LRB-
cord-002407-25cawzi0	336	43	44	44	CD
cord-002407-25cawzi0	336	44	]	]	-RRB-
cord-002407-25cawzi0	337	1	[	[	-LRB-
cord-002407-25cawzi0	337	2	45	45	CD
cord-002407-25cawzi0	337	3	]	]	-RRB-
cord-002407-25cawzi0	337	4	[	[	-LRB-
cord-002407-25cawzi0	337	5	46	46	CD
cord-002407-25cawzi0	337	6	]	]	-RRB-
cord-002407-25cawzi0	337	7	[	[	-LRB-
cord-002407-25cawzi0	337	8	74	74	CD
cord-002407-25cawzi0	337	9	]	]	-RRB-
cord-002407-25cawzi0	338	1	[	[	-LRB-
cord-002407-25cawzi0	338	2	75	75	CD
cord-002407-25cawzi0	338	3	]	]	-RRB-
cord-002407-25cawzi0	338	4	[	[	-LRB-
cord-002407-25cawzi0	338	5	76	76	CD
cord-002407-25cawzi0	338	6	]	]	-RRB-
cord-002407-25cawzi0	338	7	.	.	.
cord-002407-25cawzi0	339	1	To	to	TO
cord-002407-25cawzi0	339	2	overcome	overcome	VB
cord-002407-25cawzi0	339	3	these	these	DT
cord-002407-25cawzi0	339	4	drawbacks	drawback	NNS
cord-002407-25cawzi0	339	5	,	,	,
cord-002407-25cawzi0	339	6	different	different	JJ
cord-002407-25cawzi0	339	7	approaches	approach	NNS
cord-002407-25cawzi0	339	8	aimed	aim	VBN
cord-002407-25cawzi0	339	9	to	to	TO
cord-002407-25cawzi0	339	10	develop	develop	VB
cord-002407-25cawzi0	339	11	a	a	DT
cord-002407-25cawzi0	339	12	universal	universal	JJ
cord-002407-25cawzi0	339	13	influenza	influenza	NN
cord-002407-25cawzi0	339	14	vaccine	vaccine	NN
cord-002407-25cawzi0	339	15	able	able	JJ
cord-002407-25cawzi0	339	16	to	to	TO
cord-002407-25cawzi0	339	17	induce	induce	VB
cord-002407-25cawzi0	339	18	cross	cross	JJ
cord-002407-25cawzi0	339	19	-	-	JJ
cord-002407-25cawzi0	339	20	protective	protective	JJ
cord-002407-25cawzi0	339	21	broadly	broadly	RB
cord-002407-25cawzi0	339	22	neutralizing	neutralize	VBG
cord-002407-25cawzi0	339	23	immunity	immunity	NN
cord-002407-25cawzi0	339	24	against	against	IN
cord-002407-25cawzi0	339	25	conserved	conserve	VBN
cord-002407-25cawzi0	339	26	viral	viral	JJ
cord-002407-25cawzi0	339	27	antigens	antigen	NNS
cord-002407-25cawzi0	339	28	,	,	,
cord-002407-25cawzi0	339	29	such	such	JJ
cord-002407-25cawzi0	339	30	as	as	IN
cord-002407-25cawzi0	339	31	the	the	DT
cord-002407-25cawzi0	339	32	ectodomain	ectodomain	NNP
cord-002407-25cawzi0	339	33	of	of	IN
cord-002407-25cawzi0	339	34	M2	M2	NNP
cord-002407-25cawzi0	339	35	(	(	-LRB-
cord-002407-25cawzi0	339	36	M2e	m2e	NN
cord-002407-25cawzi0	339	37	)	)	-RRB-
cord-002407-25cawzi0	339	38	[	[	-LRB-
cord-002407-25cawzi0	339	39	199	199	CD
cord-002407-25cawzi0	339	40	]	]	-RRB-
cord-002407-25cawzi0	339	41	,	,	,
cord-002407-25cawzi0	339	42	the	the	DT
cord-002407-25cawzi0	339	43	HA	HA	NNP
cord-002407-25cawzi0	339	44	stalk	stalk	NN
cord-002407-25cawzi0	339	45	domain	domain	NN
cord-002407-25cawzi0	339	46	[	[	-LRB-
cord-002407-25cawzi0	339	47	200	200	CD
cord-002407-25cawzi0	339	48	]	]	-RRB-
cord-002407-25cawzi0	339	49	or	or	CC
cord-002407-25cawzi0	339	50	NA	NA	NNP
cord-002407-25cawzi0	339	51	[	[	-LRB-
cord-002407-25cawzi0	339	52	201	201	CD
cord-002407-25cawzi0	339	53	]	]	-RRB-
cord-002407-25cawzi0	339	54	,	,	,
cord-002407-25cawzi0	339	55	have	have	VBP
cord-002407-25cawzi0	339	56	been	be	VBN
cord-002407-25cawzi0	339	57	explored	explore	VBN
cord-002407-25cawzi0	339	58	.	.	.
cord-002407-25cawzi0	340	1	The	the	DT
cord-002407-25cawzi0	340	2	M2e	M2e	NNP
cord-002407-25cawzi0	340	3	antigen	antigen	NN
cord-002407-25cawzi0	340	4	is	be	VBZ
cord-002407-25cawzi0	340	5	a	a	DT
cord-002407-25cawzi0	340	6	linear	linear	JJ
cord-002407-25cawzi0	340	7	peptide	peptide	NN
cord-002407-25cawzi0	340	8	that	that	WDT
cord-002407-25cawzi0	340	9	is	be	VBZ
cord-002407-25cawzi0	340	10	very	very	RB
cord-002407-25cawzi0	340	11	well	well	RB
cord-002407-25cawzi0	340	12	conserved	conserve	VBN
cord-002407-25cawzi0	340	13	across	across	IN
cord-002407-25cawzi0	340	14	IAV	IAV	NNP
cord-002407-25cawzi0	340	15	strains	strain	NNS
cord-002407-25cawzi0	340	16	.	.	.
cord-002407-25cawzi0	341	1	Although	although	IN
cord-002407-25cawzi0	341	2	the	the	DT
cord-002407-25cawzi0	341	3	mechanism	mechanism	NN
cord-002407-25cawzi0	341	4	of	of	IN
cord-002407-25cawzi0	341	5	M2e	m2e	NN
cord-002407-25cawzi0	341	6	-	-	HYPH
cord-002407-25cawzi0	341	7	specific	specific	JJ
cord-002407-25cawzi0	341	8	immunity	immunity	NN
cord-002407-25cawzi0	341	9	is	be	VBZ
cord-002407-25cawzi0	341	10	unclear	unclear	JJ
cord-002407-25cawzi0	341	11	,	,	,
cord-002407-25cawzi0	341	12	protective	protective	JJ
cord-002407-25cawzi0	341	13	anti	anti	JJ
cord-002407-25cawzi0	341	14	-	-	JJ
cord-002407-25cawzi0	341	15	M2	m2	JJ
cord-002407-25cawzi0	341	16	antibodies	antibody	NNS
cord-002407-25cawzi0	341	17	have	have	VBP
cord-002407-25cawzi0	341	18	been	be	VBN
cord-002407-25cawzi0	341	19	observed	observe	VBN
cord-002407-25cawzi0	341	20	in	in	IN
cord-002407-25cawzi0	341	21	multiple	multiple	JJ
cord-002407-25cawzi0	341	22	animal	animal	NN
cord-002407-25cawzi0	341	23	models	model	NNS
cord-002407-25cawzi0	341	24	,	,	,
cord-002407-25cawzi0	341	25	including	include	VBG
cord-002407-25cawzi0	341	26	mice	mouse	NNS
cord-002407-25cawzi0	341	27	,	,	,
cord-002407-25cawzi0	341	28	ferrets	ferret	NNS
cord-002407-25cawzi0	341	29	and	and	CC
cord-002407-25cawzi0	341	30	primates	primate	NNS
cord-002407-25cawzi0	341	31	[	[	-LRB-
cord-002407-25cawzi0	341	32	36	36	CD
cord-002407-25cawzi0	341	33	]	]	-RRB-
cord-002407-25cawzi0	341	34	.	.	.
cord-002407-25cawzi0	342	1	However	however	RB
cord-002407-25cawzi0	342	2	,	,	,
cord-002407-25cawzi0	342	3	these	these	DT
cord-002407-25cawzi0	342	4	conserved	conserve	VBN
cord-002407-25cawzi0	342	5	antigenic	antigenic	JJ
cord-002407-25cawzi0	342	6	targets	target	NNS
cord-002407-25cawzi0	342	7	need	need	VBP
cord-002407-25cawzi0	342	8	to	to	TO
cord-002407-25cawzi0	342	9	be	be	VB
cord-002407-25cawzi0	342	10	presented	present	VBN
cord-002407-25cawzi0	342	11	in	in	IN
cord-002407-25cawzi0	342	12	a	a	DT
cord-002407-25cawzi0	342	13	carrier	carrier	NN
cord-002407-25cawzi0	342	14	system	system	NN
cord-002407-25cawzi0	342	15	or	or	CC
cord-002407-25cawzi0	342	16	conjugated	conjugate	VBN
cord-002407-25cawzi0	342	17	to	to	IN
cord-002407-25cawzi0	342	18	adjuvant	adjuvant	JJ
cord-002407-25cawzi0	342	19	molecules	molecule	NNS
cord-002407-25cawzi0	342	20	.	.	.
cord-002407-25cawzi0	343	1	Promising	promising	JJ
cord-002407-25cawzi0	343	2	results	result	NNS
cord-002407-25cawzi0	343	3	have	have	VBP
cord-002407-25cawzi0	343	4	been	be	VBN
cord-002407-25cawzi0	343	5	obtained	obtain	VBN
cord-002407-25cawzi0	343	6	with	with	IN
cord-002407-25cawzi0	343	7	virus	virus	NN
cord-002407-25cawzi0	343	8	-	-	HYPH
cord-002407-25cawzi0	343	9	like	like	JJ
cord-002407-25cawzi0	343	10	particles	particle	NNS
cord-002407-25cawzi0	343	11	(	(	-LRB-
cord-002407-25cawzi0	343	12	VLPs	VLPs	NNP
cord-002407-25cawzi0	343	13	)	)	-RRB-
cord-002407-25cawzi0	343	14	,	,	,
cord-002407-25cawzi0	343	15	which	which	WDT
cord-002407-25cawzi0	343	16	are	be	VBP
cord-002407-25cawzi0	343	17	morphologically	morphologically	RB
cord-002407-25cawzi0	343	18	similar	similar	JJ
cord-002407-25cawzi0	343	19	to	to	IN
cord-002407-25cawzi0	343	20	the	the	DT
cord-002407-25cawzi0	343	21	virus	virus	NN
cord-002407-25cawzi0	343	22	and	and	CC
cord-002407-25cawzi0	343	23	present	present	JJ
cord-002407-25cawzi0	343	24	surface	surface	NN
cord-002407-25cawzi0	343	25	proteins	protein	NNS
cord-002407-25cawzi0	343	26	in	in	IN
cord-002407-25cawzi0	343	27	a	a	DT
cord-002407-25cawzi0	343	28	highly	highly	RB
cord-002407-25cawzi0	343	29	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	343	30	form	form	NN
cord-002407-25cawzi0	343	31	.	.	.
cord-002407-25cawzi0	344	1	Because	because	IN
cord-002407-25cawzi0	344	2	VLPs	vlp	NNS
cord-002407-25cawzi0	344	3	do	do	VBP
cord-002407-25cawzi0	344	4	not	not	RB
cord-002407-25cawzi0	344	5	contain	contain	VB
cord-002407-25cawzi0	344	6	the	the	DT
cord-002407-25cawzi0	344	7	viral	viral	JJ
cord-002407-25cawzi0	344	8	genome	genome	NN
cord-002407-25cawzi0	344	9	,	,	,
cord-002407-25cawzi0	344	10	they	-PRON-	PRP
cord-002407-25cawzi0	344	11	are	be	VBP
cord-002407-25cawzi0	344	12	considered	consider	VBN
cord-002407-25cawzi0	344	13	safer	safe	JJR
cord-002407-25cawzi0	344	14	than	than	IN
cord-002407-25cawzi0	344	15	viral	viral	JJ
cord-002407-25cawzi0	344	16	vaccines	vaccine	NNS
cord-002407-25cawzi0	344	17	,	,	,
cord-002407-25cawzi0	344	18	yet	yet	CC
cord-002407-25cawzi0	344	19	still	still	RB
cord-002407-25cawzi0	344	20	induce	induce	VBP
cord-002407-25cawzi0	344	21	strong	strong	JJ
cord-002407-25cawzi0	344	22	humoral	humoral	JJ
cord-002407-25cawzi0	344	23	and	and	CC
cord-002407-25cawzi0	344	24	cellular	cellular	JJ
cord-002407-25cawzi0	344	25	immune	immune	JJ
cord-002407-25cawzi0	344	26	responses	response	NNS
cord-002407-25cawzi0	344	27	[	[	-LRB-
cord-002407-25cawzi0	344	28	202	202	CD
cord-002407-25cawzi0	344	29	]	]	-RRB-
cord-002407-25cawzi0	344	30	.	.	.
cord-002407-25cawzi0	345	1	VLPs	vlp	NNS
cord-002407-25cawzi0	345	2	are	be	VBP
cord-002407-25cawzi0	345	3	most	most	RBS
cord-002407-25cawzi0	345	4	commonly	commonly	RB
cord-002407-25cawzi0	345	5	made	make	VBN
cord-002407-25cawzi0	345	6	by	by	IN
cord-002407-25cawzi0	345	7	expression	expression	NN
cord-002407-25cawzi0	345	8	of	of	IN
cord-002407-25cawzi0	345	9	HA	HA	NNP
cord-002407-25cawzi0	345	10	,	,	,
cord-002407-25cawzi0	345	11	NA	NA	NNP
cord-002407-25cawzi0	345	12	and	and	CC
cord-002407-25cawzi0	345	13	M1	M1	NNP
cord-002407-25cawzi0	345	14	[	[	-LRB-
cord-002407-25cawzi0	345	15	203	203	CD
cord-002407-25cawzi0	345	16	,	,	,
cord-002407-25cawzi0	345	17	204	204	CD
cord-002407-25cawzi0	345	18	]	]	-RRB-
cord-002407-25cawzi0	345	19	,	,	,
cord-002407-25cawzi0	345	20	although	although	IN
cord-002407-25cawzi0	345	21	HA	HA	NNP
cord-002407-25cawzi0	345	22	and	and	CC
cord-002407-25cawzi0	345	23	NA	NA	NNP
cord-002407-25cawzi0	345	24	alone	alone	RB
cord-002407-25cawzi0	345	25	may	may	MD
cord-002407-25cawzi0	345	26	be	be	VB
cord-002407-25cawzi0	345	27	sufficient	sufficient	JJ
cord-002407-25cawzi0	345	28	for	for	IN
cord-002407-25cawzi0	345	29	VLP	VLP	NNP
cord-002407-25cawzi0	345	30	production	production	NN
cord-002407-25cawzi0	345	31	[	[	-LRB-
cord-002407-25cawzi0	345	32	205	205	CD
cord-002407-25cawzi0	345	33	]	]	-RRB-
cord-002407-25cawzi0	345	34	.	.	.
cord-002407-25cawzi0	345	35	 	 	_SP
cord-002407-25cawzi0	346	1	Reverse	reverse	JJ
cord-002407-25cawzi0	346	2	genetics	genetics	NN
cord-002407-25cawzi0	346	3	approaches	approach	NNS
cord-002407-25cawzi0	346	4	to	to	TO
cord-002407-25cawzi0	346	5	generate	generate	VB
cord-002407-25cawzi0	346	6	recombinant	recombinant	JJ
cord-002407-25cawzi0	346	7	viruses	virus	NNS
cord-002407-25cawzi0	346	8	,	,	,
cord-002407-25cawzi0	346	9	including	include	VBG
cord-002407-25cawzi0	346	10	influenza	influenza	NN
cord-002407-25cawzi0	346	11	,	,	,
cord-002407-25cawzi0	346	12	have	have	VBP
cord-002407-25cawzi0	346	13	been	be	VBN
cord-002407-25cawzi0	346	14	described	describe	VBN
cord-002407-25cawzi0	346	15	for	for	IN
cord-002407-25cawzi0	346	16	representative	representative	JJ
cord-002407-25cawzi0	346	17	family	family	NN
cord-002407-25cawzi0	346	18	members	member	NNS
cord-002407-25cawzi0	346	19	of	of	IN
cord-002407-25cawzi0	346	20	negative	negative	JJ
cord-002407-25cawzi0	346	21	-	-	HYPH
cord-002407-25cawzi0	346	22	sense	sense	NN
cord-002407-25cawzi0	346	23	,	,	,
cord-002407-25cawzi0	346	24	single	single	RB
cord-002407-25cawzi0	346	25	-	-	HYPH
cord-002407-25cawzi0	346	26	stranded	strand	VBN
cord-002407-25cawzi0	346	27	RNA	RNA	NNP
cord-002407-25cawzi0	346	28	viruses	virus	NNS
cord-002407-25cawzi0	346	29	.	.	.
cord-002407-25cawzi0	347	1	These	these	DT
cord-002407-25cawzi0	347	2	plasmid	plasmid	NN
cord-002407-25cawzi0	347	3	-	-	HYPH
cord-002407-25cawzi0	347	4	based	base	VBN
cord-002407-25cawzi0	347	5	reverse	reverse	JJ
cord-002407-25cawzi0	347	6	genetics	genetics	NN
cord-002407-25cawzi0	347	7	methods	method	NNS
cord-002407-25cawzi0	347	8	have	have	VBP
cord-002407-25cawzi0	347	9	provided	provide	VBN
cord-002407-25cawzi0	347	10	scientists	scientist	NNS
cord-002407-25cawzi0	347	11	with	with	IN
cord-002407-25cawzi0	347	12	a	a	DT
cord-002407-25cawzi0	347	13	unique	unique	JJ
cord-002407-25cawzi0	347	14	opportunity	opportunity	NN
cord-002407-25cawzi0	347	15	to	to	TO
cord-002407-25cawzi0	347	16	study	study	VB
cord-002407-25cawzi0	347	17	different	different	JJ
cord-002407-25cawzi0	347	18	aspects	aspect	NNS
cord-002407-25cawzi0	347	19	of	of	IN
cord-002407-25cawzi0	347	20	the	the	DT
cord-002407-25cawzi0	347	21	biology	biology	NN
cord-002407-25cawzi0	347	22	and	and	CC
cord-002407-25cawzi0	347	23	pathogenesis	pathogenesis	NN
cord-002407-25cawzi0	347	24	of	of	IN
cord-002407-25cawzi0	347	25	these	these	DT
cord-002407-25cawzi0	347	26	viruses	virus	NNS
cord-002407-25cawzi0	347	27	,	,	,
cord-002407-25cawzi0	347	28	both	both	CC
cord-002407-25cawzi0	347	29	in	in	IN
cord-002407-25cawzi0	347	30	vitro	vitro	FW
cord-002407-25cawzi0	347	31	and	and	CC
cord-002407-25cawzi0	347	32	in	in	IN
cord-002407-25cawzi0	347	33	vivo	vivo	NN
cord-002407-25cawzi0	347	34	,	,	,
cord-002407-25cawzi0	347	35	as	as	RB
cord-002407-25cawzi0	347	36	well	well	RB
cord-002407-25cawzi0	347	37	as	as	IN
cord-002407-25cawzi0	347	38	to	to	TO
cord-002407-25cawzi0	347	39	generate	generate	VB
cord-002407-25cawzi0	347	40	attenuated	attenuated	JJ
cord-002407-25cawzi0	347	41	forms	form	NNS
cord-002407-25cawzi0	347	42	to	to	TO
cord-002407-25cawzi0	347	43	be	be	VB
cord-002407-25cawzi0	347	44	used	use	VBN
cord-002407-25cawzi0	347	45	as	as	IN
cord-002407-25cawzi0	347	46	vaccines	vaccine	NNS
cord-002407-25cawzi0	347	47	[	[	-LRB-
cord-002407-25cawzi0	347	48	135	135	CD
cord-002407-25cawzi0	347	49	]	]	-RRB-
cord-002407-25cawzi0	347	50	.	.	.
cord-002407-25cawzi0	348	1	In	in	IN
cord-002407-25cawzi0	348	2	this	this	DT
cord-002407-25cawzi0	348	3	review	review	NN
cord-002407-25cawzi0	348	4	,	,	,
cord-002407-25cawzi0	348	5	we	-PRON-	PRP
cord-002407-25cawzi0	348	6	discussed	discuss	VBD
cord-002407-25cawzi0	348	7	the	the	DT
cord-002407-25cawzi0	348	8	use	use	NN
cord-002407-25cawzi0	348	9	of	of	IN
cord-002407-25cawzi0	348	10	reverse	reverse	JJ
cord-002407-25cawzi0	348	11	genetics	genetic	NNS
cord-002407-25cawzi0	348	12	for	for	IN
cord-002407-25cawzi0	348	13	the	the	DT
cord-002407-25cawzi0	348	14	generation	generation	NN
cord-002407-25cawzi0	348	15	of	of	IN
cord-002407-25cawzi0	348	16	influenza	influenza	NN
cord-002407-25cawzi0	348	17	vaccines	vaccine	NNS
cord-002407-25cawzi0	348	18	with	with	IN
cord-002407-25cawzi0	348	19	a	a	DT
cord-002407-25cawzi0	348	20	special	special	JJ
cord-002407-25cawzi0	348	21	focus	focus	NN
cord-002407-25cawzi0	348	22	on	on	IN
cord-002407-25cawzi0	348	23	LAIVs	laiv	NNS
cord-002407-25cawzi0	348	24	.	.	.
cord-002407-25cawzi0	349	1	In	in	IN
cord-002407-25cawzi0	349	2	general	general	JJ
cord-002407-25cawzi0	349	3	,	,	,
cord-002407-25cawzi0	349	4	LAIVs	laiv	NNS
cord-002407-25cawzi0	349	5	are	be	VBP
cord-002407-25cawzi0	349	6	highly	highly	RB
cord-002407-25cawzi0	349	7	immunogenic	immunogenic	JJ
cord-002407-25cawzi0	349	8	,	,	,
cord-002407-25cawzi0	349	9	and	and	CC
cord-002407-25cawzi0	349	10	immunization	immunization	NN
cord-002407-25cawzi0	349	11	usually	usually	RB
cord-002407-25cawzi0	349	12	induces	induce	VBZ
cord-002407-25cawzi0	349	13	faster	fast	RBR
cord-002407-25cawzi0	349	14	and	and	CC
cord-002407-25cawzi0	349	15	substantially	substantially	RB
cord-002407-25cawzi0	349	16	higher	high	JJR
cord-002407-25cawzi0	349	17	levels	level	NNS
cord-002407-25cawzi0	349	18	of	of	IN
cord-002407-25cawzi0	349	19	both	both	DT
cord-002407-25cawzi0	349	20	systemic	systemic	JJ
cord-002407-25cawzi0	349	21	and	and	CC
cord-002407-25cawzi0	349	22	local	local	JJ
cord-002407-25cawzi0	349	23	mucosal	mucosal	JJ
cord-002407-25cawzi0	349	24	antibody	antibody	NN
cord-002407-25cawzi0	349	25	and	and	CC
cord-002407-25cawzi0	349	26	T	t	NN
cord-002407-25cawzi0	349	27	-	-	HYPH
cord-002407-25cawzi0	349	28	cell	cell	NN
cord-002407-25cawzi0	349	29	responses	response	NNS
cord-002407-25cawzi0	349	30	,	,	,
cord-002407-25cawzi0	349	31	providing	provide	VBG
cord-002407-25cawzi0	349	32	better	well	JJR
cord-002407-25cawzi0	349	33	protection	protection	NN
cord-002407-25cawzi0	349	34	than	than	IN
cord-002407-25cawzi0	349	35	their	-PRON-	PRP$
cord-002407-25cawzi0	349	36	inactivated	inactivate	VBN
cord-002407-25cawzi0	349	37	counterparts	counterpart	NNS
cord-002407-25cawzi0	349	38	.	.	.
cord-002407-25cawzi0	350	1	Prevention	prevention	NN
cord-002407-25cawzi0	350	2	of	of	IN
cord-002407-25cawzi0	350	3	influenza	influenza	NN
cord-002407-25cawzi0	350	4	virus	virus	NN
cord-002407-25cawzi0	350	5	infection	infection	NN
cord-002407-25cawzi0	350	6	requires	require	VBZ
cord-002407-25cawzi0	350	7	seasonal	seasonal	JJ
cord-002407-25cawzi0	350	8	vaccinations	vaccination	NNS
cord-002407-25cawzi0	350	9	,	,	,
cord-002407-25cawzi0	350	10	and	and	CC
cord-002407-25cawzi0	350	11	identification	identification	NN
cord-002407-25cawzi0	350	12	of	of	IN
cord-002407-25cawzi0	350	13	the	the	DT
cord-002407-25cawzi0	350	14	correct	correct	JJ
cord-002407-25cawzi0	350	15	virus	virus	NN
cord-002407-25cawzi0	350	16	subtype	subtype	NN
cord-002407-25cawzi0	350	17	to	to	TO
cord-002407-25cawzi0	350	18	include	include	VB
cord-002407-25cawzi0	350	19	in	in	IN
cord-002407-25cawzi0	350	20	the	the	DT
cord-002407-25cawzi0	350	21	vaccine	vaccine	NN
cord-002407-25cawzi0	350	22	leaves	leave	VBZ
cord-002407-25cawzi0	350	23	little	little	JJ
cord-002407-25cawzi0	350	24	time	time	NN
cord-002407-25cawzi0	350	25	for	for	IN
cord-002407-25cawzi0	350	26	vaccine	vaccine	NN
cord-002407-25cawzi0	350	27	development	development	NN
cord-002407-25cawzi0	350	28	,	,	,
cord-002407-25cawzi0	350	29	scale	scale	VB
cord-002407-25cawzi0	350	30	up	up	RP
cord-002407-25cawzi0	350	31	and	and	CC
cord-002407-25cawzi0	350	32	distribution	distribution	NN
cord-002407-25cawzi0	350	33	.	.	.
cord-002407-25cawzi0	351	1	Although	although	IN
cord-002407-25cawzi0	351	2	influenza	influenza	NN
cord-002407-25cawzi0	351	3	vaccines	vaccine	NNS
cord-002407-25cawzi0	351	4	work	work	VBP
cord-002407-25cawzi0	351	5	well	well	RB
cord-002407-25cawzi0	351	6	most	most	JJS
cord-002407-25cawzi0	351	7	of	of	IN
cord-002407-25cawzi0	351	8	the	the	DT
cord-002407-25cawzi0	351	9	years	year	NNS
cord-002407-25cawzi0	351	10	,	,	,
cord-002407-25cawzi0	351	11	if	if	IN
cord-002407-25cawzi0	351	12	a	a	DT
cord-002407-25cawzi0	351	13	new	new	JJ
cord-002407-25cawzi0	351	14	viral	viral	JJ
cord-002407-25cawzi0	351	15	variant	variant	NN
cord-002407-25cawzi0	351	16	emerges	emerge	VBZ
cord-002407-25cawzi0	351	17	after	after	IN
cord-002407-25cawzi0	351	18	the	the	DT
cord-002407-25cawzi0	351	19	strain	strain	NN
cord-002407-25cawzi0	351	20	to	to	TO
cord-002407-25cawzi0	351	21	be	be	VB
cord-002407-25cawzi0	351	22	included	include	VBN
cord-002407-25cawzi0	351	23	in	in	IN
cord-002407-25cawzi0	351	24	the	the	DT
cord-002407-25cawzi0	351	25	vaccine	vaccine	NN
cord-002407-25cawzi0	351	26	has	have	VBZ
cord-002407-25cawzi0	351	27	been	be	VBN
cord-002407-25cawzi0	351	28	selected	select	VBN
cord-002407-25cawzi0	351	29	,	,	,
cord-002407-25cawzi0	351	30	the	the	DT
cord-002407-25cawzi0	351	31	efficacy	efficacy	NN
cord-002407-25cawzi0	351	32	of	of	IN
cord-002407-25cawzi0	351	33	the	the	DT
cord-002407-25cawzi0	351	34	vaccine	vaccine	NN
cord-002407-25cawzi0	351	35	would	would	MD
cord-002407-25cawzi0	351	36	be	be	VB
cord-002407-25cawzi0	351	37	sub	sub	NN
cord-002407-25cawzi0	351	38	-	-	JJ
cord-002407-25cawzi0	351	39	optimal	optimal	JJ
cord-002407-25cawzi0	351	40	for	for	IN
cord-002407-25cawzi0	351	41	this	this	DT
cord-002407-25cawzi0	351	42	new	new	JJ
cord-002407-25cawzi0	351	43	variant	variant	NN
cord-002407-25cawzi0	351	44	strain	strain	NN
cord-002407-25cawzi0	351	45	.	.	.
cord-002407-25cawzi0	352	1	This	this	DT
cord-002407-25cawzi0	352	2	usually	usually	RB
cord-002407-25cawzi0	352	3	results	result	VBZ
cord-002407-25cawzi0	352	4	in	in	IN
cord-002407-25cawzi0	352	5	decreased	decrease	VBN
cord-002407-25cawzi0	352	6	efficacy	efficacy	NN
cord-002407-25cawzi0	352	7	of	of	IN
cord-002407-25cawzi0	352	8	the	the	DT
cord-002407-25cawzi0	352	9	vaccine	vaccine	NN
cord-002407-25cawzi0	352	10	.	.	.
cord-002407-25cawzi0	353	1	Reverse	reverse	JJ
cord-002407-25cawzi0	353	2	genetics	genetics	NN
cord-002407-25cawzi0	353	3	approaches	approach	NNS
cord-002407-25cawzi0	353	4	have	have	VBP
cord-002407-25cawzi0	353	5	also	also	RB
cord-002407-25cawzi0	353	6	allowed	allow	VBN
cord-002407-25cawzi0	353	7	the	the	DT
cord-002407-25cawzi0	353	8	development	development	NN
cord-002407-25cawzi0	353	9	of	of	IN
cord-002407-25cawzi0	353	10	live	live	JJ
cord-002407-25cawzi0	353	11	-	-	HYPH
cord-002407-25cawzi0	353	12	attenuated	attenuate	VBN
cord-002407-25cawzi0	353	13	viruses	virus	NNS
cord-002407-25cawzi0	353	14	that	that	WDT
cord-002407-25cawzi0	353	15	could	could	MD
cord-002407-25cawzi0	353	16	be	be	VB
cord-002407-25cawzi0	353	17	implemented	implement	VBN
cord-002407-25cawzi0	353	18	,	,	,
cord-002407-25cawzi0	353	19	in	in	IN
cord-002407-25cawzi0	353	20	the	the	DT
cord-002407-25cawzi0	353	21	near	near	JJ
cord-002407-25cawzi0	353	22	future	future	NN
cord-002407-25cawzi0	353	23	,	,	,
cord-002407-25cawzi0	353	24	as	as	IN
cord-002407-25cawzi0	353	25	LAIVs	laiv	NNS
cord-002407-25cawzi0	353	26	.	.	.
cord-002407-25cawzi0	354	1	These	these	DT
cord-002407-25cawzi0	354	2	new	new	JJ
cord-002407-25cawzi0	354	3	advances	advance	NNS
cord-002407-25cawzi0	354	4	in	in	IN
cord-002407-25cawzi0	354	5	reverse	reverse	JJ
cord-002407-25cawzi0	354	6	genetics	genetics	NN
cord-002407-25cawzi0	354	7	approaches	approach	NNS
cord-002407-25cawzi0	354	8	are	be	VBP
cord-002407-25cawzi0	354	9	reducing	reduce	VBG
cord-002407-25cawzi0	354	10	the	the	DT
cord-002407-25cawzi0	354	11	potential	potential	JJ
cord-002407-25cawzi0	354	12	time	time	NN
cord-002407-25cawzi0	354	13	of	of	IN
cord-002407-25cawzi0	354	14	recovery	recovery	NN
cord-002407-25cawzi0	354	15	and	and	CC
cord-002407-25cawzi0	354	16	production	production	NN
cord-002407-25cawzi0	354	17	from	from	IN
cord-002407-25cawzi0	354	18	months	month	NNS
cord-002407-25cawzi0	354	19	to	to	IN
cord-002407-25cawzi0	354	20	weeks	week	NNS
cord-002407-25cawzi0	354	21	and	and	CC
cord-002407-25cawzi0	354	22	represent	represent	VB
cord-002407-25cawzi0	354	23	an	an	DT
cord-002407-25cawzi0	354	24	excellent	excellent	JJ
cord-002407-25cawzi0	354	25	alternative	alternative	NN
cord-002407-25cawzi0	354	26	for	for	IN
cord-002407-25cawzi0	354	27	the	the	DT
cord-002407-25cawzi0	354	28	rapid	rapid	JJ
cord-002407-25cawzi0	354	29	development	development	NN
cord-002407-25cawzi0	354	30	and	and	CC
cord-002407-25cawzi0	354	31	implementation	implementation	NN
cord-002407-25cawzi0	354	32	of	of	IN
cord-002407-25cawzi0	354	33	LAIVs	laiv	NNS
cord-002407-25cawzi0	354	34	for	for	IN
cord-002407-25cawzi0	354	35	the	the	DT
cord-002407-25cawzi0	354	36	treatment	treatment	NN
cord-002407-25cawzi0	354	37	of	of	IN
cord-002407-25cawzi0	354	38	both	both	DT
cord-002407-25cawzi0	354	39	seasonal	seasonal	JJ
cord-002407-25cawzi0	354	40	and	and	CC
cord-002407-25cawzi0	354	41	potentially	potentially	RB
cord-002407-25cawzi0	354	42	pandemic	pandemic	JJ
cord-002407-25cawzi0	354	43	influenza	influenza	NN
cord-002407-25cawzi0	354	44	strains	strain	NNS
cord-002407-25cawzi0	354	45	.	.	.
cord-002407-25cawzi0	355	1	Acknowledgments	acknowledgment	NNS
cord-002407-25cawzi0	355	2	:	:	:
cord-002407-25cawzi0	355	3	Influenza	influenza	NN
cord-002407-25cawzi0	355	4	virus	virus	NN
cord-002407-25cawzi0	355	5	research	research	NN
cord-002407-25cawzi0	355	6	in	in	IN
cord-002407-25cawzi0	355	7	the	the	DT
cord-002407-25cawzi0	355	8	Luis	Luis	NNP
cord-002407-25cawzi0	355	9	Martínez	Martínez	NNP
cord-002407-25cawzi0	355	10	-	-	HYPH
cord-002407-25cawzi0	355	11	Sobrido	Sobrido	NNP
cord-002407-25cawzi0	355	12	and	and	CC
cord-002407-25cawzi0	355	13	Aitor	Aitor	NNP
cord-002407-25cawzi0	355	14	Nogales	Nogales	NNP
cord-002407-25cawzi0	355	15	laboratory	laboratory	NN
cord-002407-25cawzi0	355	16	was	be	VBD
cord-002407-25cawzi0	355	17	partially	partially	RB
cord-002407-25cawzi0	355	18	funded	fund	VBN
cord-002407-25cawzi0	355	19	by	by	IN
cord-002407-25cawzi0	355	20	the	the	DT
cord-002407-25cawzi0	355	21	National	National	NNP
cord-002407-25cawzi0	355	22	Institute	Institute	NNP
cord-002407-25cawzi0	355	23	of	of	IN
cord-002407-25cawzi0	355	24	Allergy	Allergy	NNP
cord-002407-25cawzi0	355	25	and	and	CC
cord-002407-25cawzi0	355	26	Infectious	Infectious	NNP
cord-002407-25cawzi0	355	27	Diseases	Diseases	NNPS
cord-002407-25cawzi0	355	28	(	(	-LRB-
cord-002407-25cawzi0	355	29	NIAID	NIAID	NNP
cord-002407-25cawzi0	355	30	)	)	-RRB-
cord-002407-25cawzi0	355	31	Centers	Centers	NNPS
cord-002407-25cawzi0	355	32	of	of	IN
cord-002407-25cawzi0	355	33	Excellence	Excellence	NNP
cord-002407-25cawzi0	355	34	for	for	IN
cord-002407-25cawzi0	355	35	Influenza	Influenza	NNP
cord-002407-25cawzi0	355	36	Research	Research	NNP
cord-002407-25cawzi0	355	37	and	and	CC
cord-002407-25cawzi0	355	38	Surveillance	Surveillance	NNP
cord-002407-25cawzi0	355	39	(	(	-LRB-
cord-002407-25cawzi0	355	40	CEIRS	CEIRS	NNP
cord-002407-25cawzi0	355	41	HHSN266200700008C	hhsn266200700008c	CD
cord-002407-25cawzi0	355	42	)	)	-RRB-
cord-002407-25cawzi0	355	43	.	.	.
cord-002407-25cawzi0	356	1	The	the	DT
cord-002407-25cawzi0	356	2	authors	author	NNS
cord-002407-25cawzi0	356	3	declare	declare	VBP
cord-002407-25cawzi0	356	4	no	no	DT
cord-002407-25cawzi0	356	5	conflict	conflict	NN
cord-002407-25cawzi0	356	6	of	of	IN
cord-002407-25cawzi0	356	7	interest	interest	NN
cord-002407-25cawzi0	356	8	.	.	.
cord-002407-25cawzi0	356	9	 	 	_SP
cord-002407-25cawzi0	357	1	The	the	DT
cord-002407-25cawzi0	357	2	viruses	virus	NNS
cord-002407-25cawzi0	357	3	and	and	CC
cord-002407-25cawzi0	357	4	their	-PRON-	PRP$
cord-002407-25cawzi0	357	5	replication	replication	NN
cord-002407-25cawzi0	357	6	Transmission	transmission	NN
cord-002407-25cawzi0	357	7	of	of	IN
cord-002407-25cawzi0	357	8	influenza	influenza	NN
cord-002407-25cawzi0	357	9	virus	virus	NN
cord-002407-25cawzi0	357	10	in	in	IN
cord-002407-25cawzi0	357	11	a	a	DT
cord-002407-25cawzi0	357	12	mammalian	mammalian	JJ
cord-002407-25cawzi0	357	13	host	host	NN
cord-002407-25cawzi0	357	14	is	be	VBZ
cord-002407-25cawzi0	357	15	increased	increase	VBN
cord-002407-25cawzi0	357	16	by	by	IN
cord-002407-25cawzi0	357	17	PB2	PB2	NNP
cord-002407-25cawzi0	357	18	amino	amino	JJ
cord-002407-25cawzi0	357	19	acids	acid	NNS
cord-002407-25cawzi0	357	20	627	627	CD
cord-002407-25cawzi0	357	21	K	K	NNP
cord-002407-25cawzi0	357	22	or	or	CC
cord-002407-25cawzi0	357	23	627E/701N	627e/701n	CD
cord-002407-25cawzi0	358	1	The	the	DT
cord-002407-25cawzi0	358	2	origins	origin	NNS
cord-002407-25cawzi0	358	3	of	of	IN
cord-002407-25cawzi0	358	4	new	new	JJ
cord-002407-25cawzi0	358	5	pandemic	pandemic	NN
cord-002407-25cawzi0	358	6	viruses	virus	NNS
cord-002407-25cawzi0	358	7	:	:	:
cord-002407-25cawzi0	358	8	The	the	DT
cord-002407-25cawzi0	358	9	acquisition	acquisition	NN
cord-002407-25cawzi0	358	10	of	of	IN
cord-002407-25cawzi0	358	11	new	new	JJ
cord-002407-25cawzi0	358	12	host	host	NN
cord-002407-25cawzi0	358	13	ranges	range	NNS
cord-002407-25cawzi0	358	14	by	by	IN
cord-002407-25cawzi0	358	15	canine	canine	JJ
cord-002407-25cawzi0	358	16	parvovirus	parvovirus	NN
cord-002407-25cawzi0	358	17	and	and	CC
cord-002407-25cawzi0	358	18	influenza	influenza	NN
cord-002407-25cawzi0	358	19	A	a	DT
cord-002407-25cawzi0	358	20	viruses	virus	NNS
cord-002407-25cawzi0	359	1	Evolution	evolution	NN
cord-002407-25cawzi0	359	2	of	of	IN
cord-002407-25cawzi0	359	3	the	the	DT
cord-002407-25cawzi0	359	4	H3	H3	NNP
cord-002407-25cawzi0	359	5	influenza	influenza	NN
cord-002407-25cawzi0	359	6	virus	virus	NN
cord-002407-25cawzi0	359	7	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	359	8	from	from	IN
cord-002407-25cawzi0	359	9	human	human	JJ
cord-002407-25cawzi0	359	10	and	and	CC
cord-002407-25cawzi0	359	11	nonhuman	nonhuman	NN
cord-002407-25cawzi0	359	12	hosts	host	NNS
cord-002407-25cawzi0	360	1	The	the	DT
cord-002407-25cawzi0	360	2	evolutionary	evolutionary	JJ
cord-002407-25cawzi0	360	3	dynamics	dynamic	NNS
cord-002407-25cawzi0	360	4	of	of	IN
cord-002407-25cawzi0	360	5	human	human	JJ
cord-002407-25cawzi0	360	6	influenza	influenza	NN
cord-002407-25cawzi0	360	7	B	B	NNP
cord-002407-25cawzi0	360	8	virus	virus	NN
cord-002407-25cawzi0	360	9	Influenza	Influenza	NNP
cord-002407-25cawzi0	360	10	B	B	NNP
cord-002407-25cawzi0	360	11	virus	virus	NN
cord-002407-25cawzi0	360	12	in	in	IN
cord-002407-25cawzi0	360	13	seals	seal	NNS
cord-002407-25cawzi0	361	1	The	the	DT
cord-002407-25cawzi0	361	2	influenza	influenza	NN
cord-002407-25cawzi0	361	3	virus	virus	NN
cord-002407-25cawzi0	361	4	rna	rna	NNP
cord-002407-25cawzi0	361	5	synthesis	synthesis	NNP
cord-002407-25cawzi0	361	6	machine	machine	NN
cord-002407-25cawzi0	361	7	:	:	:
cord-002407-25cawzi0	361	8	Advances	advance	NNS
cord-002407-25cawzi0	361	9	in	in	IN
cord-002407-25cawzi0	361	10	its	-PRON-	PRP$
cord-002407-25cawzi0	361	11	structure	structure	NN
cord-002407-25cawzi0	361	12	and	and	CC
cord-002407-25cawzi0	361	13	function	function	VB
cord-002407-25cawzi0	361	14	Orthomyxovirus	Orthomyxovirus	NNP
cord-002407-25cawzi0	361	15	replication	replication	NN
cord-002407-25cawzi0	361	16	,	,	,
cord-002407-25cawzi0	361	17	transcription	transcription	NN
cord-002407-25cawzi0	361	18	,	,	,
cord-002407-25cawzi0	361	19	and	and	CC
cord-002407-25cawzi0	361	20	polyadenylation	polyadenylation	NN
cord-002407-25cawzi0	361	21	Determination	Determination	NNP
cord-002407-25cawzi0	361	22	0of	0of	NN
cord-002407-25cawzi0	361	23	influenza	influenza	NN
cord-002407-25cawzi0	361	24	virus	virus	NN
cord-002407-25cawzi0	361	25	proteins	protein	NNS
cord-002407-25cawzi0	361	26	required	require	VBN
cord-002407-25cawzi0	361	27	for	for	IN
cord-002407-25cawzi0	361	28	genome	genome	NN
cord-002407-25cawzi0	361	29	replication	replication	NN
cord-002407-25cawzi0	361	30	Fields	Fields	NNP
cord-002407-25cawzi0	361	31	Virology	Virology	NNP
cord-002407-25cawzi0	361	32	Segment	Segment	NNP
cord-002407-25cawzi0	361	33	-	-	HYPH
cord-002407-25cawzi0	361	34	specific	specific	JJ
cord-002407-25cawzi0	361	35	and	and	CC
cord-002407-25cawzi0	361	36	common	common	JJ
cord-002407-25cawzi0	361	37	nucleotide	nucleotide	JJ
cord-002407-25cawzi0	361	38	sequences	sequence	NNS
cord-002407-25cawzi0	361	39	in	in	IN
cord-002407-25cawzi0	361	40	the	the	DT
cord-002407-25cawzi0	361	41	noncoding	noncoding	JJ
cord-002407-25cawzi0	361	42	regions	region	NNS
cord-002407-25cawzi0	361	43	of	of	IN
cord-002407-25cawzi0	361	44	influenza	influenza	NN
cord-002407-25cawzi0	361	45	B	b	NN
cord-002407-25cawzi0	361	46	virus	virus	NN
cord-002407-25cawzi0	361	47	genome	genome	NN
cord-002407-25cawzi0	361	48	RNAs	rna	NNS
cord-002407-25cawzi0	362	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	362	2	A	A	NNP
cord-002407-25cawzi0	362	3	and	and	CC
cord-002407-25cawzi0	362	4	B	B	NNP
cord-002407-25cawzi0	362	5	virus	virus	NN
cord-002407-25cawzi0	362	6	intertypic	intertypic	NNP
cord-002407-25cawzi0	362	7	reassortment	reassortment	VBP
cord-002407-25cawzi0	362	8	through	through	IN
cord-002407-25cawzi0	362	9	compatible	compatible	JJ
cord-002407-25cawzi0	362	10	viral	viral	JJ
cord-002407-25cawzi0	362	11	packaging	packaging	NN
cord-002407-25cawzi0	362	12	signals	signal	NNS
cord-002407-25cawzi0	363	1	Molecular	molecular	JJ
cord-002407-25cawzi0	363	2	studies	study	NNS
cord-002407-25cawzi0	363	3	of	of	IN
cord-002407-25cawzi0	363	4	influenza	influenza	NN
cord-002407-25cawzi0	363	5	B	B	NNP
cord-002407-25cawzi0	363	6	virus	virus	NN
cord-002407-25cawzi0	363	7	in	in	IN
cord-002407-25cawzi0	363	8	the	the	DT
cord-002407-25cawzi0	363	9	reverse	reverse	JJ
cord-002407-25cawzi0	363	10	genetics	genetics	NN
cord-002407-25cawzi0	363	11	era	era	NN
cord-002407-25cawzi0	363	12	Identification	identification	NN
cord-002407-25cawzi0	363	13	of	of	IN
cord-002407-25cawzi0	363	14	a	a	DT
cord-002407-25cawzi0	363	15	novel	novel	JJ
cord-002407-25cawzi0	363	16	splice	splice	NN
cord-002407-25cawzi0	363	17	variant	variant	NN
cord-002407-25cawzi0	363	18	form	form	NN
cord-002407-25cawzi0	363	19	of	of	IN
cord-002407-25cawzi0	363	20	the	the	DT
cord-002407-25cawzi0	363	21	influenza	influenza	NN
cord-002407-25cawzi0	363	22	A	a	DT
cord-002407-25cawzi0	363	23	virus	virus	NN
cord-002407-25cawzi0	363	24	M2	m2	NN
cord-002407-25cawzi0	363	25	ion	ion	NN
cord-002407-25cawzi0	363	26	channel	channel	NN
cord-002407-25cawzi0	363	27	with	with	IN
cord-002407-25cawzi0	363	28	an	an	DT
cord-002407-25cawzi0	363	29	antigenically	antigenically	RB
cord-002407-25cawzi0	363	30	distinct	distinct	JJ
cord-002407-25cawzi0	363	31	ectodomain	ectodomain	JJ
cord-002407-25cawzi0	363	32	Eukaryotic	Eukaryotic	NNP
cord-002407-25cawzi0	363	33	coupled	couple	VBN
cord-002407-25cawzi0	363	34	tanslation	tanslation	NN
cord-002407-25cawzi0	363	35	of	of	IN
cord-002407-25cawzi0	363	36	tandem	tandem	NN
cord-002407-25cawzi0	363	37	cistrons	cistron	NNS
cord-002407-25cawzi0	363	38	:	:	:
cord-002407-25cawzi0	364	1	Identification	identification	NN
cord-002407-25cawzi0	364	2	of	of	IN
cord-002407-25cawzi0	364	3	the	the	DT
cord-002407-25cawzi0	364	4	influenza	influenza	NN
cord-002407-25cawzi0	364	5	B	B	NNP
cord-002407-25cawzi0	364	6	virus	virus	NN
cord-002407-25cawzi0	364	7	BM2	BM2	NNP
cord-002407-25cawzi0	364	8	polypeptide	polypeptide	NN
cord-002407-25cawzi0	364	9	Receptor	Receptor	NNP
cord-002407-25cawzi0	364	10	binding	binding	NN
cord-002407-25cawzi0	364	11	and	and	CC
cord-002407-25cawzi0	364	12	membrane	membrane	NN
cord-002407-25cawzi0	364	13	fusion	fusion	NN
cord-002407-25cawzi0	364	14	in	in	IN
cord-002407-25cawzi0	364	15	virus	virus	NN
cord-002407-25cawzi0	364	16	entry	entry	NN
cord-002407-25cawzi0	364	17	:	:	:
cord-002407-25cawzi0	365	1	The	the	DT
cord-002407-25cawzi0	365	2	influenza	influenza	NN
cord-002407-25cawzi0	365	3	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	366	1	The	the	DT
cord-002407-25cawzi0	366	2	structure	structure	NN
cord-002407-25cawzi0	366	3	of	of	IN
cord-002407-25cawzi0	366	4	the	the	DT
cord-002407-25cawzi0	366	5	complex	complex	NN
cord-002407-25cawzi0	366	6	between	between	IN
cord-002407-25cawzi0	366	7	influenza	influenza	NN
cord-002407-25cawzi0	366	8	virus	virus	NN
cord-002407-25cawzi0	366	9	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	366	10	and	and	CC
cord-002407-25cawzi0	366	11	sialic	sialic	JJ
cord-002407-25cawzi0	366	12	acid	acid	NN
cord-002407-25cawzi0	366	13	,	,	,
cord-002407-25cawzi0	366	14	the	the	DT
cord-002407-25cawzi0	366	15	viral	viral	JJ
cord-002407-25cawzi0	366	16	receptor	receptor	NN
cord-002407-25cawzi0	366	17	Refined	refine	VBN
cord-002407-25cawzi0	366	18	crystal	crystal	NN
cord-002407-25cawzi0	366	19	structure	structure	NN
cord-002407-25cawzi0	366	20	of	of	IN
cord-002407-25cawzi0	366	21	the	the	DT
cord-002407-25cawzi0	366	22	influenza	influenza	NN
cord-002407-25cawzi0	366	23	virus	virus	NN
cord-002407-25cawzi0	366	24	N9	N9	NNP
cord-002407-25cawzi0	366	25	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	366	26	-	-	:
cord-002407-25cawzi0	366	27	NC41	NC41	NNP
cord-002407-25cawzi0	366	28	Fab	Fab	NNP
cord-002407-25cawzi0	366	29	complex	complex	JJ
cord-002407-25cawzi0	366	30	Evolution	evolution	NN
cord-002407-25cawzi0	366	31	and	and	CC
cord-002407-25cawzi0	366	32	ecology	ecology	NN
cord-002407-25cawzi0	366	33	of	of	IN
cord-002407-25cawzi0	366	34	influenza	influenza	NN
cord-002407-25cawzi0	366	35	A	a	NN
cord-002407-25cawzi0	366	36	viruses	virus	NNS
cord-002407-25cawzi0	366	37	New	new	JJ
cord-002407-25cawzi0	366	38	world	world	NN
cord-002407-25cawzi0	366	39	bats	bat	NNS
cord-002407-25cawzi0	366	40	harbor	harbor	VBP
cord-002407-25cawzi0	366	41	diverse	diverse	JJ
cord-002407-25cawzi0	366	42	influenza	influenza	NN
cord-002407-25cawzi0	366	43	A	a	DT
cord-002407-25cawzi0	366	44	viruses	virus	NNS
cord-002407-25cawzi0	367	1	Multiple	multiple	JJ
cord-002407-25cawzi0	367	2	genotypes	genotype	NNS
cord-002407-25cawzi0	367	3	of	of	IN
cord-002407-25cawzi0	367	4	influenza	influenza	NN
cord-002407-25cawzi0	367	5	B	B	NNP
cord-002407-25cawzi0	367	6	virus	virus	NN
cord-002407-25cawzi0	367	7	circulated	circulate	VBN
cord-002407-25cawzi0	367	8	between	between	IN
cord-002407-25cawzi0	367	9	1979	1979	CD
cord-002407-25cawzi0	367	10	and	and	CC
cord-002407-25cawzi0	367	11	Evolutionary	evolutionary	JJ
cord-002407-25cawzi0	367	12	pattern	pattern	NN
cord-002407-25cawzi0	367	13	of	of	IN
cord-002407-25cawzi0	367	14	the	the	DT
cord-002407-25cawzi0	367	15	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	367	16	gene	gene	NN
cord-002407-25cawzi0	367	17	of	of	IN
cord-002407-25cawzi0	367	18	influenza	influenza	NN
cord-002407-25cawzi0	367	19	B	b	NN
cord-002407-25cawzi0	367	20	viruses	virus	NNS
cord-002407-25cawzi0	367	21	isolated	isolate	VBN
cord-002407-25cawzi0	367	22	in	in	IN
cord-002407-25cawzi0	367	23	japan	japan	NNP
cord-002407-25cawzi0	367	24	:	:	:
cord-002407-25cawzi0	367	25	Cocirculating	cocirculate	VBG
cord-002407-25cawzi0	367	26	lineages	lineage	NNS
cord-002407-25cawzi0	367	27	in	in	IN
cord-002407-25cawzi0	367	28	the	the	DT
cord-002407-25cawzi0	367	29	same	same	JJ
cord-002407-25cawzi0	367	30	epidemic	epidemic	NN
cord-002407-25cawzi0	367	31	season	season	NN
cord-002407-25cawzi0	367	32	Mortality	mortality	NN
cord-002407-25cawzi0	367	33	associated	associate	VBN
cord-002407-25cawzi0	367	34	with	with	IN
cord-002407-25cawzi0	367	35	influenza	influenza	NN
cord-002407-25cawzi0	367	36	and	and	CC
cord-002407-25cawzi0	367	37	respiratory	respiratory	JJ
cord-002407-25cawzi0	367	38	syncytial	syncytial	JJ
cord-002407-25cawzi0	367	39	virus	virus	NN
cord-002407-25cawzi0	367	40	in	in	IN
cord-002407-25cawzi0	367	41	the	the	DT
cord-002407-25cawzi0	367	42	united	united	NNP
cord-002407-25cawzi0	367	43	states	states	NNP
cord-002407-25cawzi0	367	44	Clinical	clinical	JJ
cord-002407-25cawzi0	367	45	and	and	CC
cord-002407-25cawzi0	367	46	genetic	genetic	JJ
cord-002407-25cawzi0	367	47	characterization	characterization	NN
cord-002407-25cawzi0	367	48	of	of	IN
cord-002407-25cawzi0	367	49	severe	severe	JJ
cord-002407-25cawzi0	367	50	influenza	influenza	NN
cord-002407-25cawzi0	367	51	B	b	NN
cord-002407-25cawzi0	367	52	-	-	HYPH
cord-002407-25cawzi0	367	53	associated	associate	VBN
cord-002407-25cawzi0	367	54	diseases	disease	NNS
cord-002407-25cawzi0	367	55	during	during	IN
cord-002407-25cawzi0	367	56	an	an	DT
cord-002407-25cawzi0	367	57	outbreak	outbreak	NN
cord-002407-25cawzi0	367	58	in	in	IN
cord-002407-25cawzi0	367	59	Taiwan	Taiwan	NNP
cord-002407-25cawzi0	367	60	Medically	medically	RB
cord-002407-25cawzi0	367	61	attended	attend	VBD
cord-002407-25cawzi0	367	62	pediatric	pediatric	JJ
cord-002407-25cawzi0	367	63	influenza	influenza	NN
cord-002407-25cawzi0	367	64	during	during	IN
cord-002407-25cawzi0	367	65	the	the	DT
cord-002407-25cawzi0	367	66	resurgence	resurgence	NN
cord-002407-25cawzi0	367	67	of	of	IN
cord-002407-25cawzi0	367	68	the	the	DT
cord-002407-25cawzi0	367	69	victoria	victoria	NNP
cord-002407-25cawzi0	367	70	lineage	lineage	NN
cord-002407-25cawzi0	367	71	of	of	IN
cord-002407-25cawzi0	367	72	influenza	influenza	NN
cord-002407-25cawzi0	367	73	B	B	NNP
cord-002407-25cawzi0	367	74	virus	virus	NN
cord-002407-25cawzi0	367	75	Influenza	Influenza	NNP
cord-002407-25cawzi0	367	76	virus	virus	NN
cord-002407-25cawzi0	367	77	M2	m2	NN
cord-002407-25cawzi0	367	78	protein	protein	NN
cord-002407-25cawzi0	367	79	has	have	VBZ
cord-002407-25cawzi0	367	80	ion	ion	NN
cord-002407-25cawzi0	367	81	channel	channel	NN
cord-002407-25cawzi0	367	82	activity	activity	NN
cord-002407-25cawzi0	368	1	The	the	DT
cord-002407-25cawzi0	368	2	gene	gene	NN
cord-002407-25cawzi0	368	3	structure	structure	NN
cord-002407-25cawzi0	368	4	and	and	CC
cord-002407-25cawzi0	368	5	replication	replication	NN
cord-002407-25cawzi0	368	6	of	of	IN
cord-002407-25cawzi0	368	7	influenza	influenza	NN
cord-002407-25cawzi0	368	8	virus	virus	NN
cord-002407-25cawzi0	368	9	Genome	Genome	NNP
cord-002407-25cawzi0	368	10	packaging	packaging	NN
cord-002407-25cawzi0	368	11	in	in	IN
cord-002407-25cawzi0	368	12	influenza	influenza	NN
cord-002407-25cawzi0	368	13	A	a	DT
cord-002407-25cawzi0	368	14	virus	virus	NN
cord-002407-25cawzi0	368	15	Influenza	Influenza	NNP
cord-002407-25cawzi0	368	16	virus	virus	NN
cord-002407-25cawzi0	368	17	assembly	assembly	NN
cord-002407-25cawzi0	368	18	and	and	CC
cord-002407-25cawzi0	368	19	budding	bud	VBG
cord-002407-25cawzi0	368	20	Selective	selective	JJ
cord-002407-25cawzi0	368	21	packaging	packaging	NN
cord-002407-25cawzi0	368	22	of	of	IN
cord-002407-25cawzi0	368	23	the	the	DT
cord-002407-25cawzi0	368	24	influenza	influenza	NN
cord-002407-25cawzi0	368	25	A	a	DT
cord-002407-25cawzi0	368	26	genome	genome	NN
cord-002407-25cawzi0	368	27	and	and	CC
cord-002407-25cawzi0	368	28	consequences	consequence	NNS
cord-002407-25cawzi0	368	29	for	for	IN
cord-002407-25cawzi0	368	30	genetic	genetic	JJ
cord-002407-25cawzi0	368	31	reassortment	reassortment	NN
cord-002407-25cawzi0	369	1	The	the	DT
cord-002407-25cawzi0	369	2	multifunctional	multifunctional	JJ
cord-002407-25cawzi0	369	3	NS1	ns1	NN
cord-002407-25cawzi0	369	4	protein	protein	NN
cord-002407-25cawzi0	369	5	of	of	IN
cord-002407-25cawzi0	369	6	influenza	influenza	NN
cord-002407-25cawzi0	369	7	A	a	DT
cord-002407-25cawzi0	369	8	viruses	virus	NNS
cord-002407-25cawzi0	370	1	Emerging	emerge	VBG
cord-002407-25cawzi0	370	2	roles	role	NNS
cord-002407-25cawzi0	370	3	for	for	IN
cord-002407-25cawzi0	370	4	the	the	DT
cord-002407-25cawzi0	370	5	influenza	influenza	NN
cord-002407-25cawzi0	370	6	A	a	DT
cord-002407-25cawzi0	370	7	virus	virus	NN
cord-002407-25cawzi0	370	8	nuclear	nuclear	JJ
cord-002407-25cawzi0	370	9	export	export	NN
cord-002407-25cawzi0	370	10	protein	protein	NN
cord-002407-25cawzi0	370	11	(	(	-LRB-
cord-002407-25cawzi0	370	12	NEP	NEP	NNP
cord-002407-25cawzi0	370	13	)	)	-RRB-
cord-002407-25cawzi0	371	1	Improving	improve	VBG
cord-002407-25cawzi0	371	2	influenza	influenza	JJ
cord-002407-25cawzi0	371	3	vaccine	vaccine	NN
cord-002407-25cawzi0	371	4	virus	virus	NN
cord-002407-25cawzi0	371	5	selection	selection	NN
cord-002407-25cawzi0	371	6	:	:	:
cord-002407-25cawzi0	372	1	Report	report	NN
cord-002407-25cawzi0	372	2	of	of	IN
cord-002407-25cawzi0	372	3	a	a	DT
cord-002407-25cawzi0	372	4	WHO	WHO	NNP
cord-002407-25cawzi0	372	5	informal	informal	JJ
cord-002407-25cawzi0	372	6	consultation	consultation	NN
cord-002407-25cawzi0	372	7	held	hold	VBN
cord-002407-25cawzi0	372	8	at	at	IN
cord-002407-25cawzi0	372	9	WHO	WHO	NNP
cord-002407-25cawzi0	372	10	headquarters	headquarters	NN
cord-002407-25cawzi0	372	11	Epidemiological	epidemiological	JJ
cord-002407-25cawzi0	372	12	,	,	,
cord-002407-25cawzi0	372	13	antigenic	antigenic	JJ
cord-002407-25cawzi0	372	14	and	and	CC
cord-002407-25cawzi0	372	15	genetic	genetic	JJ
cord-002407-25cawzi0	372	16	characteristics	characteristic	NNS
cord-002407-25cawzi0	372	17	of	of	IN
cord-002407-25cawzi0	372	18	seasonal	seasonal	JJ
cord-002407-25cawzi0	372	19	influenza	influenza	NN
cord-002407-25cawzi0	372	20	A	A	NNP
cord-002407-25cawzi0	372	21	(	(	-LRB-
cord-002407-25cawzi0	372	22	H1N1	H1N1	NNP
cord-002407-25cawzi0	372	23	)	)	-RRB-
cord-002407-25cawzi0	372	24	,	,	,
cord-002407-25cawzi0	372	25	a(H3N2	a(H3N2	NNP
cord-002407-25cawzi0	372	26	)	)	-RRB-
cord-002407-25cawzi0	372	27	and	and	CC
cord-002407-25cawzi0	373	1	B	b	NN
cord-002407-25cawzi0	373	2	influenza	influenza	NN
cord-002407-25cawzi0	373	3	viruses	virus	NNS
cord-002407-25cawzi0	373	4	:	:	:
cord-002407-25cawzi0	374	1	Basis	basis	NN
cord-002407-25cawzi0	374	2	for	for	IN
cord-002407-25cawzi0	374	3	the	the	DT
cord-002407-25cawzi0	374	4	WHO	WHO	NNP
cord-002407-25cawzi0	374	5	recommendation	recommendation	NN
cord-002407-25cawzi0	374	6	on	on	IN
cord-002407-25cawzi0	374	7	the	the	DT
cord-002407-25cawzi0	374	8	composition	composition	NN
cord-002407-25cawzi0	374	9	of	of	IN
cord-002407-25cawzi0	374	10	influenza	influenza	NN
cord-002407-25cawzi0	374	11	vaccines	vaccine	NNS
cord-002407-25cawzi0	374	12	for	for	IN
cord-002407-25cawzi0	374	13	use	use	NN
cord-002407-25cawzi0	374	14	in	in	IN
cord-002407-25cawzi0	374	15	the	the	DT
cord-002407-25cawzi0	374	16	2009	2009	CD
cord-002407-25cawzi0	374	17	-	-	SYM
cord-002407-25cawzi0	374	18	2010	2010	CD
cord-002407-25cawzi0	374	19	northern	northern	JJ
cord-002407-25cawzi0	374	20	hemisphere	hemisphere	NN
cord-002407-25cawzi0	374	21	season	season	NN
cord-002407-25cawzi0	374	22	Influenza	Influenza	NNP
cord-002407-25cawzi0	374	23	:	:	:
cord-002407-25cawzi0	374	24	Global	global	JJ
cord-002407-25cawzi0	374	25	surveillance	surveillance	NN
cord-002407-25cawzi0	374	26	for	for	IN
cord-002407-25cawzi0	374	27	epidemic	epidemic	NN
cord-002407-25cawzi0	374	28	and	and	CC
cord-002407-25cawzi0	374	29	pandemic	pandemic	NN
cord-002407-25cawzi0	374	30	variants	variant	NNS
cord-002407-25cawzi0	375	1	Novel	novel	JJ
cord-002407-25cawzi0	375	2	vaccines	vaccine	NNS
cord-002407-25cawzi0	375	3	against	against	IN
cord-002407-25cawzi0	375	4	influenza	influenza	NN
cord-002407-25cawzi0	375	5	viruses	virus	NNS
cord-002407-25cawzi0	376	1	Influenza	influenza	NN
cord-002407-25cawzi0	376	2	:	:	:
cord-002407-25cawzi0	377	1	Evolving	evolve	VBG
cord-002407-25cawzi0	377	2	strategies	strategy	NNS
cord-002407-25cawzi0	377	3	in	in	IN
cord-002407-25cawzi0	377	4	treatment	treatment	NN
cord-002407-25cawzi0	377	5	and	and	CC
cord-002407-25cawzi0	377	6	prevention	prevention	NN
cord-002407-25cawzi0	378	1	The	the	DT
cord-002407-25cawzi0	378	2	annual	annual	JJ
cord-002407-25cawzi0	378	3	impact	impact	NN
cord-002407-25cawzi0	378	4	of	of	IN
cord-002407-25cawzi0	378	5	seasonal	seasonal	JJ
cord-002407-25cawzi0	378	6	influenza	influenza	NN
cord-002407-25cawzi0	378	7	in	in	IN
cord-002407-25cawzi0	378	8	the	the	DT
cord-002407-25cawzi0	378	9	us	us	NNP
cord-002407-25cawzi0	378	10	:	:	:
cord-002407-25cawzi0	378	11	Measuring	measure	VBG
cord-002407-25cawzi0	378	12	disease	disease	NN
cord-002407-25cawzi0	378	13	burden	burden	NN
cord-002407-25cawzi0	378	14	and	and	CC
cord-002407-25cawzi0	378	15	costs	cost	VBZ
cord-002407-25cawzi0	378	16	A	a	DT
cord-002407-25cawzi0	378	17	review	review	NN
cord-002407-25cawzi0	378	18	of	of	IN
cord-002407-25cawzi0	378	19	vaccine	vaccine	NN
cord-002407-25cawzi0	378	20	research	research	NN
cord-002407-25cawzi0	378	21	and	and	CC
cord-002407-25cawzi0	378	22	development	development	NN
cord-002407-25cawzi0	378	23	:	:	:
cord-002407-25cawzi0	378	24	Human	human	JJ
cord-002407-25cawzi0	378	25	acute	acute	JJ
cord-002407-25cawzi0	378	26	respiratory	respiratory	JJ
cord-002407-25cawzi0	378	27	infections	infection	NNS
cord-002407-25cawzi0	379	1	The	the	DT
cord-002407-25cawzi0	379	2	impact	impact	NN
cord-002407-25cawzi0	379	3	of	of	IN
cord-002407-25cawzi0	379	4	influenza	influenza	NN
cord-002407-25cawzi0	379	5	on	on	IN
cord-002407-25cawzi0	379	6	working	work	VBG
cord-002407-25cawzi0	379	7	days	day	NNS
cord-002407-25cawzi0	379	8	lost	lose	VBD
cord-002407-25cawzi0	379	9	:	:	:
cord-002407-25cawzi0	379	10	A	a	DT
cord-002407-25cawzi0	379	11	review	review	NN
cord-002407-25cawzi0	379	12	of	of	IN
cord-002407-25cawzi0	379	13	the	the	DT
cord-002407-25cawzi0	379	14	literature	literature	NN
cord-002407-25cawzi0	380	1	The	the	DT
cord-002407-25cawzi0	380	2	burden	burden	NN
cord-002407-25cawzi0	380	3	of	of	IN
cord-002407-25cawzi0	380	4	influenza	influenza	NN
cord-002407-25cawzi0	380	5	B	b	NN
cord-002407-25cawzi0	380	6	:	:	:
cord-002407-25cawzi0	380	7	A	a	DT
cord-002407-25cawzi0	380	8	structured	structured	JJ
cord-002407-25cawzi0	380	9	literature	literature	NN
cord-002407-25cawzi0	380	10	review	review	NN
cord-002407-25cawzi0	380	11	Clinical	clinical	JJ
cord-002407-25cawzi0	380	12	and	and	CC
cord-002407-25cawzi0	380	13	socioeconomic	socioeconomic	JJ
cord-002407-25cawzi0	380	14	impact	impact	NN
cord-002407-25cawzi0	380	15	of	of	IN
cord-002407-25cawzi0	380	16	seasonal	seasonal	JJ
cord-002407-25cawzi0	380	17	and	and	CC
cord-002407-25cawzi0	380	18	pandemic	pandemic	NN
cord-002407-25cawzi0	380	19	influenza	influenza	NN
cord-002407-25cawzi0	380	20	in	in	IN
cord-002407-25cawzi0	380	21	adults	adult	NNS
cord-002407-25cawzi0	380	22	and	and	CC
cord-002407-25cawzi0	380	23	the	the	DT
cord-002407-25cawzi0	380	24	elderly	elderly	JJ
cord-002407-25cawzi0	380	25	.	.	.
cord-002407-25cawzi0	381	1	Hum	Hum	NNP
cord-002407-25cawzi0	381	2	.	.	.
cord-002407-25cawzi0	382	1	Vaccines	vaccine	NNS
cord-002407-25cawzi0	382	2	Immunother	Immunother	NNP
cord-002407-25cawzi0	382	3	Origins	Origins	NNPS
cord-002407-25cawzi0	382	4	and	and	CC
cord-002407-25cawzi0	382	5	evolutionary	evolutionary	JJ
cord-002407-25cawzi0	382	6	genomics	genomic	NNS
cord-002407-25cawzi0	382	7	of	of	IN
cord-002407-25cawzi0	382	8	the	the	DT
cord-002407-25cawzi0	382	9	2009	2009	CD
cord-002407-25cawzi0	382	10	swine	swine	NN
cord-002407-25cawzi0	382	11	-	-	HYPH
cord-002407-25cawzi0	382	12	origin	origin	NN
cord-002407-25cawzi0	382	13	H1N1	H1N1	NNP
cord-002407-25cawzi0	382	14	influenza	influenza	NN
cord-002407-25cawzi0	382	15	A	a	DT
cord-002407-25cawzi0	382	16	epidemic	epidemic	NN
cord-002407-25cawzi0	383	1	Influenza	influenza	NN
cord-002407-25cawzi0	383	2	pandemics	pandemic	NNS
cord-002407-25cawzi0	383	3	of	of	IN
cord-002407-25cawzi0	383	4	the	the	DT
cord-002407-25cawzi0	383	5	20th	20th	JJ
cord-002407-25cawzi0	383	6	century	century	NN
cord-002407-25cawzi0	383	7	Influenza	Influenza	NNP
cord-002407-25cawzi0	383	8	vaccine	vaccine	NN
cord-002407-25cawzi0	383	9	:	:	:
cord-002407-25cawzi0	384	1	The	the	DT
cord-002407-25cawzi0	384	2	challenge	challenge	NN
cord-002407-25cawzi0	384	3	of	of	IN
cord-002407-25cawzi0	384	4	antigenic	antigenic	JJ
cord-002407-25cawzi0	384	5	drift	drift	NN
cord-002407-25cawzi0	384	6	Reassortment	Reassortment	NNP
cord-002407-25cawzi0	384	7	and	and	CC
cord-002407-25cawzi0	384	8	evolution	evolution	NN
cord-002407-25cawzi0	384	9	of	of	IN
cord-002407-25cawzi0	384	10	current	current	JJ
cord-002407-25cawzi0	384	11	human	human	JJ
cord-002407-25cawzi0	384	12	influenza	influenza	NN
cord-002407-25cawzi0	384	13	A	a	NN
cord-002407-25cawzi0	384	14	and	and	CC
cord-002407-25cawzi0	384	15	B	b	NN
cord-002407-25cawzi0	384	16	viruses	virus	NNS
cord-002407-25cawzi0	385	1	Discordant	discordant	JJ
cord-002407-25cawzi0	385	2	antigenic	antigenic	JJ
cord-002407-25cawzi0	385	3	drift	drift	NN
cord-002407-25cawzi0	385	4	of	of	IN
cord-002407-25cawzi0	385	5	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	385	6	and	and	CC
cord-002407-25cawzi0	385	7	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	385	8	in	in	IN
cord-002407-25cawzi0	385	9	H1N1	H1N1	NNP
cord-002407-25cawzi0	385	10	and	and	CC
cord-002407-25cawzi0	385	11	H3N2	H3N2	NNP
cord-002407-25cawzi0	385	12	influenza	influenza	NN
cord-002407-25cawzi0	385	13	viruses	virus	NNS
cord-002407-25cawzi0	386	1	Intrinsic	intrinsic	JJ
cord-002407-25cawzi0	386	2	interference	interference	NN
cord-002407-25cawzi0	386	3	between	between	IN
cord-002407-25cawzi0	386	4	influenza	influenza	NN
cord-002407-25cawzi0	386	5	A	a	NN
cord-002407-25cawzi0	386	6	and	and	CC
cord-002407-25cawzi0	386	7	B	b	NN
cord-002407-25cawzi0	386	8	viruses	virus	NNS
cord-002407-25cawzi0	387	1	influenza	influenza	NN
cord-002407-25cawzi0	387	2	:	:	:
cord-002407-25cawzi0	388	1	The	the	DT
cord-002407-25cawzi0	388	2	mother	mother	NN
cord-002407-25cawzi0	388	3	of	of	IN
cord-002407-25cawzi0	388	4	all	all	DT
cord-002407-25cawzi0	388	5	pandemics	pandemic	NNS
cord-002407-25cawzi0	388	6	Update	update	VBP
cord-002407-25cawzi0	388	7	:	:	:
cord-002407-25cawzi0	388	8	Infections	infection	NNS
cord-002407-25cawzi0	388	9	with	with	IN
cord-002407-25cawzi0	388	10	a	a	DT
cord-002407-25cawzi0	388	11	swine	swine	NN
cord-002407-25cawzi0	388	12	-	-	HYPH
cord-002407-25cawzi0	388	13	Origin	origin	NN
cord-002407-25cawzi0	388	14	influenza	influenza	NN
cord-002407-25cawzi0	388	15	A	a	NN
cord-002407-25cawzi0	388	16	(	(	-LRB-
cord-002407-25cawzi0	388	17	H1N1	H1N1	NNP
cord-002407-25cawzi0	388	18	)	)	-RRB-
cord-002407-25cawzi0	388	19	virus	virus	NN
cord-002407-25cawzi0	388	20	-	-	:
cord-002407-25cawzi0	388	21	United	United	NNP
cord-002407-25cawzi0	388	22	States	States	NNP
cord-002407-25cawzi0	388	23	and	and	CC
cord-002407-25cawzi0	388	24	other	other	JJ
cord-002407-25cawzi0	388	25	countries	country	NNS
cord-002407-25cawzi0	389	1	Pandemic	Pandemic	NNP
cord-002407-25cawzi0	389	2	(	(	-LRB-
cord-002407-25cawzi0	389	3	H1N1	H1N1	NNP
cord-002407-25cawzi0	389	4	)	)	-RRB-
cord-002407-25cawzi0	390	1	2009-Update	2009-update	CD
cord-002407-25cawzi0	391	1	112	112	CD
cord-002407-25cawzi0	391	2	Global	global	JJ
cord-002407-25cawzi0	391	3	concerns	concern	NNS
cord-002407-25cawzi0	391	4	regarding	regard	VBG
cord-002407-25cawzi0	391	5	novel	novel	NN
cord-002407-25cawzi0	391	6	influenza	influenza	NN
cord-002407-25cawzi0	391	7	A	a	NN
cord-002407-25cawzi0	391	8	(	(	-LRB-
cord-002407-25cawzi0	391	9	H7N9	H7N9	NNP
cord-002407-25cawzi0	391	10	)	)	-RRB-
cord-002407-25cawzi0	391	11	virus	virus	NN
cord-002407-25cawzi0	391	12	infections	infection	NNS
cord-002407-25cawzi0	391	13	Pandemic	Pandemic	NNP
cord-002407-25cawzi0	391	14	influenza	influenza	NN
cord-002407-25cawzi0	391	15	as	as	IN
cord-002407-25cawzi0	391	16	a	a	DT
cord-002407-25cawzi0	391	17	current	current	JJ
cord-002407-25cawzi0	391	18	threat	threat	NN
cord-002407-25cawzi0	391	19	A	a	DT
cord-002407-25cawzi0	391	20	large	large	JJ
cord-002407-25cawzi0	391	21	outbreak	outbreak	NN
cord-002407-25cawzi0	391	22	of	of	IN
cord-002407-25cawzi0	391	23	influenza	influenza	NN
cord-002407-25cawzi0	391	24	A	a	NN
cord-002407-25cawzi0	391	25	and	and	CC
cord-002407-25cawzi0	391	26	B	b	NN
cord-002407-25cawzi0	391	27	on	on	IN
cord-002407-25cawzi0	391	28	a	a	DT
cord-002407-25cawzi0	391	29	cruise	cruise	NN
cord-002407-25cawzi0	391	30	ship	ship	NN
cord-002407-25cawzi0	391	31	causing	cause	VBG
cord-002407-25cawzi0	391	32	widespread	widespread	JJ
cord-002407-25cawzi0	391	33	morbidity	morbidity	NN
cord-002407-25cawzi0	391	34	From	from	IN
cord-002407-25cawzi0	391	35	the	the	DT
cord-002407-25cawzi0	391	36	centers	center	NNS
cord-002407-25cawzi0	391	37	for	for	IN
cord-002407-25cawzi0	391	38	disease	disease	NN
cord-002407-25cawzi0	391	39	control	control	NN
cord-002407-25cawzi0	391	40	and	and	CC
cord-002407-25cawzi0	391	41	prevention	prevention	NN
cord-002407-25cawzi0	391	42	.	.	.
cord-002407-25cawzi0	392	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	392	2	B	B	NNP
cord-002407-25cawzi0	392	3	virus	virus	NN
cord-002407-25cawzi0	392	4	outbreak	outbreak	NN
cord-002407-25cawzi0	392	5	in	in	IN
cord-002407-25cawzi0	392	6	a	a	DT
cord-002407-25cawzi0	392	7	cruise	cruise	NN
cord-002407-25cawzi0	392	8	ship	ship	NN
cord-002407-25cawzi0	392	9	-	-	:
cord-002407-25cawzi0	392	10	Northern	Northern	NNP
cord-002407-25cawzi0	392	11	europe	europe	NNP
cord-002407-25cawzi0	393	1	An	an	DT
cord-002407-25cawzi0	393	2	outbreak	outbreak	NN
cord-002407-25cawzi0	393	3	of	of	IN
cord-002407-25cawzi0	393	4	influenza	influenza	NN
cord-002407-25cawzi0	393	5	B	b	NN
cord-002407-25cawzi0	393	6	at	at	IN
cord-002407-25cawzi0	393	7	an	an	DT
cord-002407-25cawzi0	393	8	indiana	indiana	NNP
cord-002407-25cawzi0	393	9	boarding	boarding	NN
cord-002407-25cawzi0	393	10	school	school	NN
cord-002407-25cawzi0	393	11	:	:	:
cord-002407-25cawzi0	393	12	Estimate	estimate	NN
cord-002407-25cawzi0	393	13	of	of	IN
cord-002407-25cawzi0	393	14	vaccine	vaccine	NN
cord-002407-25cawzi0	393	15	efficacy	efficacy	NN
cord-002407-25cawzi0	394	1	An	an	DT
cord-002407-25cawzi0	394	2	outbreak	outbreak	NN
cord-002407-25cawzi0	394	3	of	of	IN
cord-002407-25cawzi0	394	4	influenza	influenza	NN
cord-002407-25cawzi0	394	5	B	b	NN
cord-002407-25cawzi0	394	6	in	in	IN
cord-002407-25cawzi0	394	7	a	a	DT
cord-002407-25cawzi0	394	8	closed	closed	JJ
cord-002407-25cawzi0	394	9	community	community	NN
cord-002407-25cawzi0	394	10	school	school	NN
cord-002407-25cawzi0	394	11	in	in	IN
cord-002407-25cawzi0	394	12	Uganda	Uganda	NNP
cord-002407-25cawzi0	394	13	.	.	.
cord-002407-25cawzi0	395	1	East	East	NNP
cord-002407-25cawzi0	395	2	An	an	DT
cord-002407-25cawzi0	395	3	outbreak	outbreak	NN
cord-002407-25cawzi0	395	4	of	of	IN
cord-002407-25cawzi0	395	5	influenza	influenza	NN
cord-002407-25cawzi0	395	6	due	due	IN
cord-002407-25cawzi0	395	7	to	to	IN
cord-002407-25cawzi0	395	8	type	type	NN
cord-002407-25cawzi0	395	9	B	b	NN
cord-002407-25cawzi0	395	10	virus	virus	NN
cord-002407-25cawzi0	395	11	in	in	IN
cord-002407-25cawzi0	395	12	a	a	DT
cord-002407-25cawzi0	395	13	residential	residential	JJ
cord-002407-25cawzi0	395	14	boys	boy	NNS
cord-002407-25cawzi0	395	15	'	'	POS
cord-002407-25cawzi0	395	16	school	school	NN
cord-002407-25cawzi0	395	17	in	in	IN
cord-002407-25cawzi0	395	18	Malaya	Malaya	NNP
cord-002407-25cawzi0	395	19	Efficacy	Efficacy	NNP
cord-002407-25cawzi0	395	20	and	and	CC
cord-002407-25cawzi0	395	21	effectiveness	effectiveness	NN
cord-002407-25cawzi0	395	22	of	of	IN
cord-002407-25cawzi0	395	23	influenza	influenza	NN
cord-002407-25cawzi0	395	24	vaccines	vaccine	NNS
cord-002407-25cawzi0	395	25	:	:	:
cord-002407-25cawzi0	395	26	A	a	DT
cord-002407-25cawzi0	395	27	systematic	systematic	JJ
cord-002407-25cawzi0	395	28	review	review	NN
cord-002407-25cawzi0	395	29	and	and	CC
cord-002407-25cawzi0	395	30	meta	meta	NNP
cord-002407-25cawzi0	395	31	-	-	HYPH
cord-002407-25cawzi0	395	32	analysis	analysis	NN
cord-002407-25cawzi0	395	33	Oseltamivir	Oseltamivir	NNP
cord-002407-25cawzi0	395	34	resistance	resistance	NN
cord-002407-25cawzi0	395	35	during	during	IN
cord-002407-25cawzi0	395	36	treatment	treatment	NN
cord-002407-25cawzi0	395	37	of	of	IN
cord-002407-25cawzi0	395	38	influenza	influenza	NN
cord-002407-25cawzi0	395	39	A	a	NN
cord-002407-25cawzi0	395	40	(	(	-LRB-
cord-002407-25cawzi0	395	41	H5N1	H5N1	NNP
cord-002407-25cawzi0	395	42	)	)	-RRB-
cord-002407-25cawzi0	395	43	infection	infection	NN
cord-002407-25cawzi0	395	44	Zanamivir	Zanamivir	NNP
cord-002407-25cawzi0	395	45	-	-	HYPH
cord-002407-25cawzi0	395	46	resistant	resistant	JJ
cord-002407-25cawzi0	395	47	influenza	influenza	NN
cord-002407-25cawzi0	395	48	viruses	virus	NNS
cord-002407-25cawzi0	395	49	with	with	IN
cord-002407-25cawzi0	395	50	a	a	DT
cord-002407-25cawzi0	395	51	novel	novel	NN
cord-002407-25cawzi0	395	52	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	395	53	mutation	mutation	NN
cord-002407-25cawzi0	395	54	Detection	detection	NN
cord-002407-25cawzi0	395	55	of	of	IN
cord-002407-25cawzi0	395	56	influenza	influenza	NN
cord-002407-25cawzi0	395	57	viruses	virus	NNS
cord-002407-25cawzi0	395	58	resistant	resistant	JJ
cord-002407-25cawzi0	395	59	to	to	IN
cord-002407-25cawzi0	395	60	neuraminidase	neuraminidase	FW
cord-002407-25cawzi0	395	61	inhibitors	inhibitor	NNS
cord-002407-25cawzi0	395	62	in	in	IN
cord-002407-25cawzi0	395	63	global	global	JJ
cord-002407-25cawzi0	395	64	surveillance	surveillance	NN
cord-002407-25cawzi0	395	65	during	during	IN
cord-002407-25cawzi0	395	66	the	the	DT
cord-002407-25cawzi0	395	67	first	first	JJ
cord-002407-25cawzi0	395	68	3	3	CD
cord-002407-25cawzi0	395	69	years	year	NNS
cord-002407-25cawzi0	395	70	of	of	IN
cord-002407-25cawzi0	395	71	their	-PRON-	PRP$
cord-002407-25cawzi0	395	72	use	use	NN
cord-002407-25cawzi0	396	1	Live	live	VB
cord-002407-25cawzi0	396	2	attenuated	attenuated	JJ
cord-002407-25cawzi0	396	3	versus	versus	IN
cord-002407-25cawzi0	396	4	inactivated	inactivate	VBN
cord-002407-25cawzi0	396	5	influenza	influenza	NN
cord-002407-25cawzi0	396	6	vaccine	vaccine	NN
cord-002407-25cawzi0	396	7	in	in	IN
cord-002407-25cawzi0	396	8	infants	infant	NNS
cord-002407-25cawzi0	396	9	and	and	CC
cord-002407-25cawzi0	396	10	young	young	JJ
cord-002407-25cawzi0	396	11	children	child	NNS
cord-002407-25cawzi0	397	1	Comparative	comparative	JJ
cord-002407-25cawzi0	397	2	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	397	3	of	of	IN
cord-002407-25cawzi0	397	4	trivalent	trivalent	JJ
cord-002407-25cawzi0	397	5	influenza	influenza	NN
cord-002407-25cawzi0	397	6	vaccine	vaccine	NN
cord-002407-25cawzi0	397	7	administered	administer	VBN
cord-002407-25cawzi0	397	8	by	by	IN
cord-002407-25cawzi0	397	9	intradermal	intradermal	JJ
cord-002407-25cawzi0	397	10	or	or	CC
cord-002407-25cawzi0	397	11	intramuscular	intramuscular	JJ
cord-002407-25cawzi0	397	12	route	route	NN
cord-002407-25cawzi0	397	13	in	in	IN
cord-002407-25cawzi0	397	14	healthy	healthy	JJ
cord-002407-25cawzi0	397	15	adults	adult	NNS
cord-002407-25cawzi0	398	1	Development	development	NN
cord-002407-25cawzi0	398	2	of	of	IN
cord-002407-25cawzi0	398	3	new	new	JJ
cord-002407-25cawzi0	398	4	generation	generation	NN
cord-002407-25cawzi0	398	5	influenza	influenza	NN
cord-002407-25cawzi0	398	6	vaccines	vaccine	NNS
cord-002407-25cawzi0	398	7	:	:	:
cord-002407-25cawzi0	398	8	Recipes	recipe	NNS
cord-002407-25cawzi0	398	9	for	for	IN
cord-002407-25cawzi0	398	10	success	success	NN
cord-002407-25cawzi0	398	11	?	?	.
cord-002407-25cawzi0	399	1	Vaccine	Vaccine	NNP
cord-002407-25cawzi0	399	2	Flublok	Flublok	NNP
cord-002407-25cawzi0	399	3	,	,	,
cord-002407-25cawzi0	399	4	a	a	DT
cord-002407-25cawzi0	399	5	recombinant	recombinant	JJ
cord-002407-25cawzi0	399	6	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	399	7	influenza	influenza	NN
cord-002407-25cawzi0	399	8	vaccine	vaccine	NN
cord-002407-25cawzi0	399	9	.	.	.
cord-002407-25cawzi0	400	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	400	2	Other	other	JJ
cord-002407-25cawzi0	400	3	Respir	Respir	NNP
cord-002407-25cawzi0	400	4	.	.	.
cord-002407-25cawzi0	401	1	Viruses	Viruses	NNPS
cord-002407-25cawzi0	401	2	Protection	Protection	NNP
cord-002407-25cawzi0	401	3	against	against	IN
cord-002407-25cawzi0	401	4	lethal	lethal	JJ
cord-002407-25cawzi0	401	5	influenza	influenza	NN
cord-002407-25cawzi0	401	6	with	with	IN
cord-002407-25cawzi0	401	7	a	a	DT
cord-002407-25cawzi0	401	8	viral	viral	JJ
cord-002407-25cawzi0	401	9	mimic	mimic	JJ
cord-002407-25cawzi0	401	10	Approval	Approval	NNP
cord-002407-25cawzi0	401	11	Letter	Letter	NNP
cord-002407-25cawzi0	401	12	-	-	HYPH
cord-002407-25cawzi0	401	13	Fluarix	Fluarix	NNP
cord-002407-25cawzi0	401	14	Quadrivalent	Quadrivalent	NNP
cord-002407-25cawzi0	401	15	(	(	-LRB-
cord-002407-25cawzi0	401	16	BL	BL	NNP
cord-002407-25cawzi0	401	17	125127/513	125127/513	NNS
cord-002407-25cawzi0	401	18	)	)	-RRB-
cord-002407-25cawzi0	402	1	Effectiveness	effectiveness	NN
cord-002407-25cawzi0	402	2	of	of	IN
cord-002407-25cawzi0	402	3	inactivated	inactivate	VBN
cord-002407-25cawzi0	402	4	influenza	influenza	NN
cord-002407-25cawzi0	402	5	vaccines	vaccine	NNS
cord-002407-25cawzi0	402	6	varied	vary	VBN
cord-002407-25cawzi0	402	7	substantially	substantially	RB
cord-002407-25cawzi0	402	8	with	with	IN
cord-002407-25cawzi0	402	9	antigenic	antigenic	JJ
cord-002407-25cawzi0	402	10	match	match	NN
cord-002407-25cawzi0	402	11	from	from	IN
cord-002407-25cawzi0	402	12	the	the	DT
cord-002407-25cawzi0	402	13	2004	2004	CD
cord-002407-25cawzi0	402	14	-	-	SYM
cord-002407-25cawzi0	402	15	2005	2005	CD
cord-002407-25cawzi0	402	16	season	season	NN
cord-002407-25cawzi0	402	17	to	to	IN
cord-002407-25cawzi0	402	18	the	the	DT
cord-002407-25cawzi0	402	19	2006	2006	CD
cord-002407-25cawzi0	402	20	-	-	SYM
cord-002407-25cawzi0	402	21	2007	2007	CD
cord-002407-25cawzi0	402	22	season	season	NN
cord-002407-25cawzi0	402	23	Toward	toward	IN
cord-002407-25cawzi0	402	24	a	a	DT
cord-002407-25cawzi0	402	25	universal	universal	JJ
cord-002407-25cawzi0	402	26	influenza	influenza	NN
cord-002407-25cawzi0	402	27	virus	virus	NN
cord-002407-25cawzi0	402	28	vaccine	vaccine	NN
cord-002407-25cawzi0	402	29	:	:	:
cord-002407-25cawzi0	402	30	Prospects	prospect	NNS
cord-002407-25cawzi0	402	31	and	and	CC
cord-002407-25cawzi0	402	32	challenges	challenge	VBZ
cord-002407-25cawzi0	402	33	Superiority	superiority	NN
cord-002407-25cawzi0	402	34	of	of	IN
cord-002407-25cawzi0	402	35	live	live	RB
cord-002407-25cawzi0	402	36	-	-	HYPH
cord-002407-25cawzi0	402	37	attenuated	attenuated	JJ
cord-002407-25cawzi0	402	38	compared	compare	VBN
cord-002407-25cawzi0	402	39	with	with	IN
cord-002407-25cawzi0	402	40	inactivated	inactivate	VBN
cord-002407-25cawzi0	402	41	influenza	influenza	NN
cord-002407-25cawzi0	402	42	A	a	DT
cord-002407-25cawzi0	402	43	virus	virus	NN
cord-002407-25cawzi0	402	44	vaccines	vaccine	NNS
cord-002407-25cawzi0	402	45	in	in	IN
cord-002407-25cawzi0	402	46	older	old	JJR
cord-002407-25cawzi0	402	47	,	,	,
cord-002407-25cawzi0	402	48	chronically	chronically	RB
cord-002407-25cawzi0	402	49	ill	ill	JJ
cord-002407-25cawzi0	402	50	adults	adult	NNS
cord-002407-25cawzi0	403	1	Antiviral	antiviral	JJ
cord-002407-25cawzi0	403	2	response	response	NN
cord-002407-25cawzi0	403	3	in	in	IN
cord-002407-25cawzi0	403	4	pandemic	pandemic	NN
cord-002407-25cawzi0	403	5	influenza	influenza	NN
cord-002407-25cawzi0	403	6	viruses	viruse	VBZ
cord-002407-25cawzi0	403	7	Treatment	treatment	NN
cord-002407-25cawzi0	403	8	of	of	IN
cord-002407-25cawzi0	403	9	epidemic	epidemic	NN
cord-002407-25cawzi0	403	10	and	and	CC
cord-002407-25cawzi0	403	11	pandemic	pandemic	NN
cord-002407-25cawzi0	403	12	influenza	influenza	NN
cord-002407-25cawzi0	403	13	with	with	IN
cord-002407-25cawzi0	403	14	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	403	15	and	and	CC
cord-002407-25cawzi0	403	16	M2	M2	NNP
cord-002407-25cawzi0	403	17	proton	proton	NN
cord-002407-25cawzi0	403	18	channel	channel	NN
cord-002407-25cawzi0	403	19	inhibitors	inhibitors	NNP
cord-002407-25cawzi0	403	20	Oseltamivir	Oseltamivir	NNP
cord-002407-25cawzi0	403	21	-	-	HYPH
cord-002407-25cawzi0	403	22	resistant	resistant	JJ
cord-002407-25cawzi0	403	23	variants	variant	NNS
cord-002407-25cawzi0	403	24	of	of	IN
cord-002407-25cawzi0	403	25	the	the	DT
cord-002407-25cawzi0	403	26	2009	2009	CD
cord-002407-25cawzi0	403	27	pandemic	pandemic	NN
cord-002407-25cawzi0	403	28	H1N1	H1N1	NNP
cord-002407-25cawzi0	403	29	influenza	influenza	NN
cord-002407-25cawzi0	403	30	A	a	DT
cord-002407-25cawzi0	403	31	virus	virus	NN
cord-002407-25cawzi0	403	32	are	be	VBP
cord-002407-25cawzi0	403	33	not	not	RB
cord-002407-25cawzi0	403	34	attenuated	attenuate	VBN
cord-002407-25cawzi0	403	35	in	in	IN
cord-002407-25cawzi0	403	36	the	the	DT
cord-002407-25cawzi0	403	37	guinea	guinea	NN
cord-002407-25cawzi0	403	38	pig	pig	NN
cord-002407-25cawzi0	403	39	and	and	CC
cord-002407-25cawzi0	403	40	ferret	ferret	NN
cord-002407-25cawzi0	403	41	transmission	transmission	NN
cord-002407-25cawzi0	403	42	models	model	NNS
cord-002407-25cawzi0	403	43	Oseltamivir	Oseltamivir	NNP
cord-002407-25cawzi0	403	44	,	,	,
cord-002407-25cawzi0	403	45	zanamivir	zanamivir	NNP
cord-002407-25cawzi0	403	46	and	and	CC
cord-002407-25cawzi0	403	47	amantadine	amantadine	NNP
cord-002407-25cawzi0	403	48	in	in	IN
cord-002407-25cawzi0	403	49	the	the	DT
cord-002407-25cawzi0	403	50	prevention	prevention	NN
cord-002407-25cawzi0	403	51	of	of	IN
cord-002407-25cawzi0	403	52	influenza	influenza	NN
cord-002407-25cawzi0	403	53	:	:	:
cord-002407-25cawzi0	404	1	A	a	DT
cord-002407-25cawzi0	404	2	systematic	systematic	JJ
cord-002407-25cawzi0	404	3	review	review	NN
cord-002407-25cawzi0	405	1	Triple	triple	JJ
cord-002407-25cawzi0	405	2	combination	combination	NN
cord-002407-25cawzi0	405	3	of	of	IN
cord-002407-25cawzi0	405	4	amantadine	amantadine	NN
cord-002407-25cawzi0	405	5	,	,	,
cord-002407-25cawzi0	405	6	ribavirin	ribavirin	NN
cord-002407-25cawzi0	405	7	,	,	,
cord-002407-25cawzi0	405	8	and	and	CC
cord-002407-25cawzi0	405	9	oseltamivir	oseltamivir	NN
cord-002407-25cawzi0	405	10	is	be	VBZ
cord-002407-25cawzi0	405	11	highly	highly	RB
cord-002407-25cawzi0	405	12	active	active	JJ
cord-002407-25cawzi0	405	13	and	and	CC
cord-002407-25cawzi0	405	14	synergistic	synergistic	JJ
cord-002407-25cawzi0	405	15	against	against	IN
cord-002407-25cawzi0	405	16	drug	drug	NN
cord-002407-25cawzi0	405	17	resistant	resistant	JJ
cord-002407-25cawzi0	405	18	influenza	influenza	NN
cord-002407-25cawzi0	405	19	virus	virus	NN
cord-002407-25cawzi0	405	20	strains	strain	NNS
cord-002407-25cawzi0	405	21	in	in	IN
cord-002407-25cawzi0	405	22	vitro	vitro	FW
cord-002407-25cawzi0	406	1	The	the	DT
cord-002407-25cawzi0	406	2	molecular	molecular	JJ
cord-002407-25cawzi0	406	3	basis	basis	NN
cord-002407-25cawzi0	406	4	of	of	IN
cord-002407-25cawzi0	406	5	the	the	DT
cord-002407-25cawzi0	406	6	specific	specific	JJ
cord-002407-25cawzi0	406	7	anti	anti	JJ
cord-002407-25cawzi0	406	8	-	-	JJ
cord-002407-25cawzi0	406	9	influenza	influenza	JJ
cord-002407-25cawzi0	406	10	action	action	NN
cord-002407-25cawzi0	406	11	of	of	IN
cord-002407-25cawzi0	406	12	amantadine	amantadine	NNP
cord-002407-25cawzi0	406	13	Influenza	Influenza	NNP
cord-002407-25cawzi0	406	14	virus	virus	NN
cord-002407-25cawzi0	406	15	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	406	16	inhibitors	inhibitor	NNS
cord-002407-25cawzi0	406	17	Neuraminidase	Neuraminidase	NNP
cord-002407-25cawzi0	406	18	inhibitors	inhibitor	NNS
cord-002407-25cawzi0	406	19	for	for	IN
cord-002407-25cawzi0	406	20	influenza	influenza	NN
cord-002407-25cawzi0	406	21	B	b	NN
cord-002407-25cawzi0	406	22	virus	virus	NN
cord-002407-25cawzi0	406	23	infection	infection	NN
cord-002407-25cawzi0	406	24	:	:	:
cord-002407-25cawzi0	407	1	Efficacy	efficacy	NN
cord-002407-25cawzi0	407	2	and	and	CC
cord-002407-25cawzi0	407	3	resistance	resistance	NN
cord-002407-25cawzi0	407	4	Review	Review	NNP
cord-002407-25cawzi0	407	5	of	of	IN
cord-002407-25cawzi0	407	6	the	the	DT
cord-002407-25cawzi0	407	7	clinical	clinical	JJ
cord-002407-25cawzi0	407	8	effectiveness	effectiveness	NN
cord-002407-25cawzi0	407	9	of	of	IN
cord-002407-25cawzi0	407	10	the	the	DT
cord-002407-25cawzi0	407	11	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	407	12	inhibitors	inhibitor	NNS
cord-002407-25cawzi0	407	13	against	against	IN
cord-002407-25cawzi0	407	14	influenza	influenza	NN
cord-002407-25cawzi0	407	15	B	b	NN
cord-002407-25cawzi0	407	16	viruses	virus	NNS
cord-002407-25cawzi0	407	17	Influenza	Influenza	NNP
cord-002407-25cawzi0	407	18	drug	drug	NN
cord-002407-25cawzi0	407	19	resistance	resistance	NN
cord-002407-25cawzi0	407	20	Assessment	Assessment	NNP
cord-002407-25cawzi0	407	21	of	of	IN
cord-002407-25cawzi0	407	22	pandemic	pandemic	NN
cord-002407-25cawzi0	407	23	and	and	CC
cord-002407-25cawzi0	407	24	seasonal	seasonal	JJ
cord-002407-25cawzi0	407	25	influenza	influenza	NN
cord-002407-25cawzi0	407	26	A	a	NN
cord-002407-25cawzi0	407	27	(	(	-LRB-
cord-002407-25cawzi0	407	28	H1N1	H1N1	NNP
cord-002407-25cawzi0	407	29	)	)	-RRB-
cord-002407-25cawzi0	407	30	virus	virus	NN
cord-002407-25cawzi0	407	31	susceptibility	susceptibility	NN
cord-002407-25cawzi0	407	32	to	to	IN
cord-002407-25cawzi0	407	33	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	407	34	inhibitors	inhibitor	NNS
cord-002407-25cawzi0	407	35	in	in	IN
cord-002407-25cawzi0	408	1	three	three	CD
cord-002407-25cawzi0	408	2	enzyme	enzyme	NN
cord-002407-25cawzi0	408	3	activity	activity	NN
cord-002407-25cawzi0	408	4	inhibition	inhibition	NN
cord-002407-25cawzi0	408	5	assays	assay	NNS
cord-002407-25cawzi0	408	6	Strengthening	strengthen	VBG
cord-002407-25cawzi0	408	7	the	the	DT
cord-002407-25cawzi0	408	8	influenza	influenza	NN
cord-002407-25cawzi0	408	9	vaccine	vaccine	NN
cord-002407-25cawzi0	408	10	virus	virus	NN
cord-002407-25cawzi0	408	11	selection	selection	NN
cord-002407-25cawzi0	408	12	and	and	CC
cord-002407-25cawzi0	408	13	development	development	NN
cord-002407-25cawzi0	408	14	process	process	NN
cord-002407-25cawzi0	409	1	Influenza	influenza	NN
cord-002407-25cawzi0	409	2	vaccine	vaccine	NN
cord-002407-25cawzi0	409	3	strain	strain	NN
cord-002407-25cawzi0	409	4	selection	selection	NN
cord-002407-25cawzi0	409	5	and	and	CC
cord-002407-25cawzi0	409	6	recent	recent	JJ
cord-002407-25cawzi0	409	7	studies	study	NNS
cord-002407-25cawzi0	409	8	on	on	IN
cord-002407-25cawzi0	409	9	the	the	DT
cord-002407-25cawzi0	409	10	global	global	JJ
cord-002407-25cawzi0	409	11	migration	migration	NN
cord-002407-25cawzi0	409	12	of	of	IN
cord-002407-25cawzi0	409	13	seasonal	seasonal	JJ
cord-002407-25cawzi0	409	14	influenza	influenza	NN
cord-002407-25cawzi0	409	15	viruses	virus	NNS
cord-002407-25cawzi0	410	1	Heterosubtypic	heterosubtypic	JJ
cord-002407-25cawzi0	410	2	immunity	immunity	NN
cord-002407-25cawzi0	410	3	to	to	IN
cord-002407-25cawzi0	410	4	influenza	influenza	NN
cord-002407-25cawzi0	410	5	type	type	VB
cord-002407-25cawzi0	410	6	A	a	DT
cord-002407-25cawzi0	410	7	virus	virus	NN
cord-002407-25cawzi0	410	8	in	in	IN
cord-002407-25cawzi0	410	9	mice	mouse	NNS
cord-002407-25cawzi0	410	10	.	.	.
cord-002407-25cawzi0	411	1	Effector	effector	NN
cord-002407-25cawzi0	411	2	mechanisms	mechanism	NNS
cord-002407-25cawzi0	411	3	and	and	CC
cord-002407-25cawzi0	411	4	their	-PRON-	PRP$
cord-002407-25cawzi0	411	5	longevity	longevity	NN
cord-002407-25cawzi0	411	6	H1N1	H1N1	NNP
cord-002407-25cawzi0	411	7	vaccine	vaccine	NN
cord-002407-25cawzi0	411	8	protects	protect	VBZ
cord-002407-25cawzi0	411	9	against	against	IN
cord-002407-25cawzi0	411	10	1918	1918	CD
cord-002407-25cawzi0	411	11	Spanish	spanish	JJ
cord-002407-25cawzi0	411	12	influenza	influenza	NN
cord-002407-25cawzi0	411	13	virus	virus	NN
cord-002407-25cawzi0	411	14	Advances	advance	VBZ
cord-002407-25cawzi0	411	15	in	in	IN
cord-002407-25cawzi0	411	16	universal	universal	JJ
cord-002407-25cawzi0	411	17	influenza	influenza	NN
cord-002407-25cawzi0	411	18	virus	virus	NN
cord-002407-25cawzi0	411	19	vaccine	vaccine	NN
cord-002407-25cawzi0	411	20	design	design	NN
cord-002407-25cawzi0	411	21	and	and	CC
cord-002407-25cawzi0	411	22	antibody	antibody	NN
cord-002407-25cawzi0	411	23	mediated	mediate	VBN
cord-002407-25cawzi0	411	24	therapies	therapy	NNS
cord-002407-25cawzi0	411	25	based	base	VBN
cord-002407-25cawzi0	411	26	on	on	IN
cord-002407-25cawzi0	411	27	conserved	conserved	JJ
cord-002407-25cawzi0	411	28	regions	region	NNS
cord-002407-25cawzi0	411	29	of	of	IN
cord-002407-25cawzi0	411	30	the	the	DT
cord-002407-25cawzi0	411	31	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	411	32	Current	current	JJ
cord-002407-25cawzi0	411	33	and	and	CC
cord-002407-25cawzi0	411	34	emerging	emerge	VBG
cord-002407-25cawzi0	411	35	cell	cell	NN
cord-002407-25cawzi0	411	36	culture	culture	NN
cord-002407-25cawzi0	411	37	manufacturing	manufacturing	NN
cord-002407-25cawzi0	411	38	technologies	technology	NNS
cord-002407-25cawzi0	411	39	for	for	IN
cord-002407-25cawzi0	411	40	influenza	influenza	NN
cord-002407-25cawzi0	411	41	vaccines	vaccine	NNS
cord-002407-25cawzi0	411	42	Efficacy	Efficacy	NNP
cord-002407-25cawzi0	411	43	of	of	IN
cord-002407-25cawzi0	411	44	inactivated	inactivate	VBN
cord-002407-25cawzi0	411	45	influenza	influenza	NN
cord-002407-25cawzi0	411	46	A	a	DT
cord-002407-25cawzi0	411	47	virus	virus	NN
cord-002407-25cawzi0	411	48	(	(	-LRB-
cord-002407-25cawzi0	411	49	H3N2	H3N2	NNP
cord-002407-25cawzi0	411	50	)	)	-RRB-
cord-002407-25cawzi0	411	51	vaccines	vaccine	NNS
cord-002407-25cawzi0	411	52	grown	grow	VBN
cord-002407-25cawzi0	411	53	in	in	IN
cord-002407-25cawzi0	411	54	mammalian	mammalian	JJ
cord-002407-25cawzi0	411	55	cells	cell	NNS
cord-002407-25cawzi0	411	56	or	or	CC
cord-002407-25cawzi0	411	57	embryonated	embryonate	VBN
cord-002407-25cawzi0	411	58	eggs	egg	NNS
cord-002407-25cawzi0	411	59	Influence	influence	NN
cord-002407-25cawzi0	411	60	of	of	IN
cord-002407-25cawzi0	411	61	host	host	NN
cord-002407-25cawzi0	411	62	cell	cell	NN
cord-002407-25cawzi0	411	63	-	-	HYPH
cord-002407-25cawzi0	411	64	mediated	mediate	VBN
cord-002407-25cawzi0	411	65	variation	variation	NN
cord-002407-25cawzi0	411	66	on	on	IN
cord-002407-25cawzi0	411	67	the	the	DT
cord-002407-25cawzi0	411	68	international	international	JJ
cord-002407-25cawzi0	411	69	surveillance	surveillance	NN
cord-002407-25cawzi0	411	70	of	of	IN
cord-002407-25cawzi0	411	71	influenza	influenza	NN
cord-002407-25cawzi0	411	72	A	a	NN
cord-002407-25cawzi0	411	73	(	(	-LRB-
cord-002407-25cawzi0	411	74	H3N2	H3N2	NNP
cord-002407-25cawzi0	411	75	)	)	-RRB-
cord-002407-25cawzi0	411	76	viruses	virus	NNS
cord-002407-25cawzi0	411	77	Strengthening	strengthen	VBG
cord-002407-25cawzi0	411	78	the	the	DT
cord-002407-25cawzi0	411	79	influenza	influenza	NN
cord-002407-25cawzi0	411	80	vaccine	vaccine	NN
cord-002407-25cawzi0	411	81	virus	virus	NN
cord-002407-25cawzi0	411	82	selection	selection	NN
cord-002407-25cawzi0	411	83	and	and	CC
cord-002407-25cawzi0	411	84	development	development	NN
cord-002407-25cawzi0	411	85	process	process	NN
cord-002407-25cawzi0	411	86	.	.	.
cord-002407-25cawzi0	412	1	Presented	present	VBN
cord-002407-25cawzi0	412	2	at	at	IN
cord-002407-25cawzi0	412	3	the	the	DT
cord-002407-25cawzi0	412	4	3rd	3rd	NN
cord-002407-25cawzi0	412	5	WHO	WHO	NNP
cord-002407-25cawzi0	412	6	Informal	Informal	NNP
cord-002407-25cawzi0	412	7	Consultation	Consultation	NNP
cord-002407-25cawzi0	412	8	for	for	IN
cord-002407-25cawzi0	412	9	Improving	improve	VBG
cord-002407-25cawzi0	412	10	Influenza	Influenza	NNP
cord-002407-25cawzi0	412	11	Vaccine	Vaccine	NNP
cord-002407-25cawzi0	412	12	Virus	Virus	NNP
cord-002407-25cawzi0	412	13	Selection	Selection	NNP
cord-002407-25cawzi0	412	14	Control	Control	NNP
cord-002407-25cawzi0	412	15	of	of	IN
cord-002407-25cawzi0	412	16	influenza	influenza	NN
cord-002407-25cawzi0	412	17	and	and	CC
cord-002407-25cawzi0	412	18	poliomyelitis	poliomyelitis	NN
cord-002407-25cawzi0	412	19	with	with	IN
cord-002407-25cawzi0	412	20	killed	kill	VBN
cord-002407-25cawzi0	412	21	virus	virus	NN
cord-002407-25cawzi0	412	22	vaccines	vaccine	NNS
cord-002407-25cawzi0	412	23	Efficacy	Efficacy	NNP
cord-002407-25cawzi0	412	24	and	and	CC
cord-002407-25cawzi0	412	25	safety	safety	NN
cord-002407-25cawzi0	412	26	of	of	IN
cord-002407-25cawzi0	412	27	a	a	DT
cord-002407-25cawzi0	412	28	live	live	RB
cord-002407-25cawzi0	412	29	-	-	HYPH
cord-002407-25cawzi0	412	30	attenuated	attenuate	VBN
cord-002407-25cawzi0	412	31	influenza	influenza	NN
cord-002407-25cawzi0	412	32	vaccine	vaccine	NN
cord-002407-25cawzi0	412	33	in	in	IN
cord-002407-25cawzi0	412	34	adults	adult	NNS
cord-002407-25cawzi0	412	35	60	60	CD
cord-002407-25cawzi0	412	36	years	year	NNS
cord-002407-25cawzi0	412	37	of	of	IN
cord-002407-25cawzi0	412	38	age	age	NN
cord-002407-25cawzi0	412	39	and	and	CC
cord-002407-25cawzi0	412	40	older	old	JJR
cord-002407-25cawzi0	412	41	Live	live	JJ
cord-002407-25cawzi0	412	42	attenuated	attenuated	JJ
cord-002407-25cawzi0	412	43	and	and	CC
cord-002407-25cawzi0	412	44	inactivated	inactivate	VBN
cord-002407-25cawzi0	412	45	viral	viral	JJ
cord-002407-25cawzi0	412	46	vaccine	vaccine	NN
cord-002407-25cawzi0	412	47	formulation	formulation	NN
cord-002407-25cawzi0	412	48	and	and	CC
cord-002407-25cawzi0	412	49	nasal	nasal	NN
cord-002407-25cawzi0	412	50	delivery	delivery	NN
cord-002407-25cawzi0	412	51	:	:	:
cord-002407-25cawzi0	413	1	Potential	potential	JJ
cord-002407-25cawzi0	413	2	and	and	CC
cord-002407-25cawzi0	413	3	challenges	challenge	VBZ
cord-002407-25cawzi0	413	4	Preparation	preparation	NN
cord-002407-25cawzi0	413	5	and	and	CC
cord-002407-25cawzi0	413	6	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	413	7	of	of	IN
cord-002407-25cawzi0	413	8	an	an	DT
cord-002407-25cawzi0	413	9	influenza	influenza	NN
cord-002407-25cawzi0	413	10	virus	virus	NN
cord-002407-25cawzi0	413	11	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	413	12	and	and	CC
cord-002407-25cawzi0	413	13	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	413	14	subunit	subunit	NN
cord-002407-25cawzi0	413	15	vaccine	vaccine	NN
cord-002407-25cawzi0	413	16	Traditional	traditional	JJ
cord-002407-25cawzi0	413	17	and	and	CC
cord-002407-25cawzi0	413	18	new	new	JJ
cord-002407-25cawzi0	413	19	influenza	influenza	NN
cord-002407-25cawzi0	413	20	vaccines	vaccine	NNS
cord-002407-25cawzi0	413	21	Antibody	Antibody	NNP
cord-002407-25cawzi0	413	22	response	response	NN
cord-002407-25cawzi0	413	23	in	in	IN
cord-002407-25cawzi0	413	24	humans	human	NNS
cord-002407-25cawzi0	413	25	to	to	IN
cord-002407-25cawzi0	413	26	deoxycholate	deoxycholate	NN
cord-002407-25cawzi0	413	27	-	-	HYPH
cord-002407-25cawzi0	413	28	treated	treat	VBN
cord-002407-25cawzi0	413	29	influenza	influenza	NN
cord-002407-25cawzi0	413	30	virus	virus	NN
cord-002407-25cawzi0	413	31	vaccine	vaccine	NN
cord-002407-25cawzi0	413	32	Evaluation	Evaluation	NNP
cord-002407-25cawzi0	413	33	of	of	IN
cord-002407-25cawzi0	413	34	the	the	DT
cord-002407-25cawzi0	413	35	safety	safety	NN
cord-002407-25cawzi0	413	36	,	,	,
cord-002407-25cawzi0	413	37	reactogenicity	reactogenicity	NN
cord-002407-25cawzi0	413	38	and	and	CC
cord-002407-25cawzi0	413	39	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	413	40	of	of	IN
cord-002407-25cawzi0	413	41	flublok(r	flublok(r	NN
cord-002407-25cawzi0	413	42	)	)	-RRB-
cord-002407-25cawzi0	413	43	trivalent	trivalent	JJ
cord-002407-25cawzi0	413	44	recombinant	recombinant	JJ
cord-002407-25cawzi0	413	45	baculovirus	baculovirus	NN
cord-002407-25cawzi0	413	46	-	-	HYPH
cord-002407-25cawzi0	413	47	expressed	express	VBN
cord-002407-25cawzi0	413	48	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	413	49	influenza	influenza	NN
cord-002407-25cawzi0	413	50	vaccine	vaccine	NN
cord-002407-25cawzi0	413	51	administered	administer	VBN
cord-002407-25cawzi0	413	52	intramuscularly	intramuscularly	RB
cord-002407-25cawzi0	413	53	to	to	IN
cord-002407-25cawzi0	413	54	healthy	healthy	JJ
cord-002407-25cawzi0	413	55	adults	adult	NNS
cord-002407-25cawzi0	413	56	50	50	CD
cord-002407-25cawzi0	413	57	-	-	SYM
cord-002407-25cawzi0	413	58	64	64	CD
cord-002407-25cawzi0	413	59	years	year	NNS
cord-002407-25cawzi0	413	60	of	of	IN
cord-002407-25cawzi0	413	61	age	age	NN
cord-002407-25cawzi0	413	62	A	a	DT
cord-002407-25cawzi0	413	63	study	study	NN
cord-002407-25cawzi0	413	64	of	of	IN
cord-002407-25cawzi0	413	65	conditions	condition	NNS
cord-002407-25cawzi0	413	66	for	for	IN
cord-002407-25cawzi0	413	67	the	the	DT
cord-002407-25cawzi0	413	68	optimum	optimum	JJ
cord-002407-25cawzi0	413	69	production	production	NN
cord-002407-25cawzi0	413	70	of	of	IN
cord-002407-25cawzi0	413	71	PR8	PR8	NNP
cord-002407-25cawzi0	413	72	influenza	influenza	NN
cord-002407-25cawzi0	413	73	virus	virus	NN
cord-002407-25cawzi0	413	74	in	in	IN
cord-002407-25cawzi0	413	75	chick	chick	NN
cord-002407-25cawzi0	413	76	embryos	embryo	NNS
cord-002407-25cawzi0	414	1	The	the	DT
cord-002407-25cawzi0	414	2	development	development	NN
cord-002407-25cawzi0	414	3	of	of	IN
cord-002407-25cawzi0	414	4	live	live	RB
cord-002407-25cawzi0	414	5	-	-	HYPH
cord-002407-25cawzi0	414	6	attenuated	attenuate	VBN
cord-002407-25cawzi0	414	7	cold	cold	NN
cord-002407-25cawzi0	414	8	-	-	HYPH
cord-002407-25cawzi0	414	9	adapted	adapt	VBN
cord-002407-25cawzi0	414	10	influenza	influenza	NN
cord-002407-25cawzi0	414	11	virus	virus	NN
cord-002407-25cawzi0	414	12	vaccine	vaccine	NN
cord-002407-25cawzi0	414	13	for	for	IN
cord-002407-25cawzi0	414	14	humans	human	NNS
cord-002407-25cawzi0	414	15	Four	four	CD
cord-002407-25cawzi0	414	16	viral	viral	JJ
cord-002407-25cawzi0	414	17	genes	gene	NNS
cord-002407-25cawzi0	414	18	independently	independently	RB
cord-002407-25cawzi0	414	19	contribute	contribute	VBP
cord-002407-25cawzi0	414	20	to	to	IN
cord-002407-25cawzi0	414	21	attenuation	attenuation	NN
cord-002407-25cawzi0	414	22	of	of	IN
cord-002407-25cawzi0	414	23	live	live	JJ
cord-002407-25cawzi0	414	24	influenza	influenza	NN
cord-002407-25cawzi0	414	25	A	A	NNP
cord-002407-25cawzi0	414	26	/	/	SYM
cord-002407-25cawzi0	414	27	Ann	Ann	NNP
cord-002407-25cawzi0	414	28	Arbor/6/60	Arbor/6/60	NNP
cord-002407-25cawzi0	414	29	(	(	-LRB-
cord-002407-25cawzi0	414	30	H2N2	H2N2	NNP
cord-002407-25cawzi0	414	31	)	)	-RRB-
cord-002407-25cawzi0	414	32	cold	cold	RB
cord-002407-25cawzi0	414	33	-	-	HYPH
cord-002407-25cawzi0	414	34	adapted	adapt	VBN
cord-002407-25cawzi0	414	35	reassortant	reassortant	JJ
cord-002407-25cawzi0	414	36	virus	virus	NN
cord-002407-25cawzi0	414	37	vaccines	vaccine	NNS
cord-002407-25cawzi0	414	38	Identification	identification	NN
cord-002407-25cawzi0	414	39	of	of	IN
cord-002407-25cawzi0	414	40	sequence	sequence	NN
cord-002407-25cawzi0	414	41	changes	change	NNS
cord-002407-25cawzi0	414	42	in	in	IN
cord-002407-25cawzi0	414	43	the	the	DT
cord-002407-25cawzi0	414	44	cold	cold	NN
cord-002407-25cawzi0	414	45	-	-	HYPH
cord-002407-25cawzi0	414	46	adapted	adapt	VBN
cord-002407-25cawzi0	414	47	,	,	,
cord-002407-25cawzi0	414	48	live	live	RB
cord-002407-25cawzi0	414	49	-	-	HYPH
cord-002407-25cawzi0	414	50	attenuated	attenuate	VBN
cord-002407-25cawzi0	414	51	influenza	influenza	NN
cord-002407-25cawzi0	414	52	vaccine	vaccine	NN
cord-002407-25cawzi0	414	53	strain	strain	NN
cord-002407-25cawzi0	414	54	,	,	,
cord-002407-25cawzi0	414	55	A	A	NNP
cord-002407-25cawzi0	414	56	/	/	SYM
cord-002407-25cawzi0	414	57	Ann	Ann	NNP
cord-002407-25cawzi0	414	58	Arbor/6/60	Arbor/6/60	NNP
cord-002407-25cawzi0	414	59	(	(	-LRB-
cord-002407-25cawzi0	414	60	H2N2	H2N2	NNP
cord-002407-25cawzi0	414	61	)	)	-RRB-
cord-002407-25cawzi0	415	1	Plaque	plaque	NN
cord-002407-25cawzi0	415	2	formation	formation	NN
cord-002407-25cawzi0	415	3	of	of	IN
cord-002407-25cawzi0	415	4	influenza	influenza	NN
cord-002407-25cawzi0	415	5	virus	virus	NN
cord-002407-25cawzi0	415	6	at	at	IN
cord-002407-25cawzi0	415	7	25	25	CD
cord-002407-25cawzi0	415	8	•	•	NNS
cord-002407-25cawzi0	416	1	C	C	NNP
cord-002407-25cawzi0	416	2	Improvement	improvement	NN
cord-002407-25cawzi0	416	3	of	of	IN
cord-002407-25cawzi0	416	4	inactivated	inactivate	VBN
cord-002407-25cawzi0	416	5	influenza	influenza	NN
cord-002407-25cawzi0	416	6	virus	virus	NN
cord-002407-25cawzi0	416	7	vaccines	vaccine	NNS
cord-002407-25cawzi0	416	8	Molecular	molecular	JJ
cord-002407-25cawzi0	416	9	studies	study	NNS
cord-002407-25cawzi0	416	10	of	of	IN
cord-002407-25cawzi0	416	11	temperature	temperature	NN
cord-002407-25cawzi0	416	12	-	-	HYPH
cord-002407-25cawzi0	416	13	sensitive	sensitive	JJ
cord-002407-25cawzi0	416	14	replication	replication	NN
cord-002407-25cawzi0	416	15	of	of	IN
cord-002407-25cawzi0	416	16	the	the	DT
cord-002407-25cawzi0	416	17	cold	cold	NN
cord-002407-25cawzi0	416	18	-	-	HYPH
cord-002407-25cawzi0	416	19	adapted	adapt	VBN
cord-002407-25cawzi0	416	20	B	B	NNP
cord-002407-25cawzi0	416	21	/	/	SYM
cord-002407-25cawzi0	416	22	Ann	Ann	NNP
cord-002407-25cawzi0	416	23	Arbor/1/66	Arbor/1/66	NNP
cord-002407-25cawzi0	416	24	,	,	,
cord-002407-25cawzi0	416	25	the	the	DT
cord-002407-25cawzi0	416	26	master	master	NN
cord-002407-25cawzi0	416	27	donor	donor	NN
cord-002407-25cawzi0	416	28	virus	virus	NN
cord-002407-25cawzi0	416	29	for	for	IN
cord-002407-25cawzi0	416	30	live	live	RB
cord-002407-25cawzi0	416	31	-	-	HYPH
cord-002407-25cawzi0	416	32	attenuated	attenuate	VBN
cord-002407-25cawzi0	416	33	influenza	influenza	NN
cord-002407-25cawzi0	416	34	flumist	flumist	NNP
cord-002407-25cawzi0	416	35	vaccines	vaccine	VBZ
cord-002407-25cawzi0	416	36	Multiple	multiple	JJ
cord-002407-25cawzi0	416	37	gene	gene	NN
cord-002407-25cawzi0	416	38	segments	segment	NNS
cord-002407-25cawzi0	416	39	control	control	VBP
cord-002407-25cawzi0	416	40	the	the	DT
cord-002407-25cawzi0	416	41	temperature	temperature	NN
cord-002407-25cawzi0	416	42	sensitivity	sensitivity	NN
cord-002407-25cawzi0	416	43	and	and	CC
cord-002407-25cawzi0	416	44	attenuation	attenuation	NN
cord-002407-25cawzi0	416	45	phenotypes	phenotype	NNS
cord-002407-25cawzi0	416	46	of	of	IN
cord-002407-25cawzi0	416	47	ca	ca	NNP
cord-002407-25cawzi0	416	48	B	B	NNP
cord-002407-25cawzi0	416	49	/	/	SYM
cord-002407-25cawzi0	416	50	Ann	Ann	NNP
cord-002407-25cawzi0	416	51	Arbor/1/66	Arbor/1/66	NNP
cord-002407-25cawzi0	416	52	Sequence	sequence	NN
cord-002407-25cawzi0	416	53	comparison	comparison	NN
cord-002407-25cawzi0	416	54	of	of	IN
cord-002407-25cawzi0	416	55	wild	wild	JJ
cord-002407-25cawzi0	416	56	-	-	HYPH
cord-002407-25cawzi0	416	57	type	type	NN
cord-002407-25cawzi0	416	58	and	and	CC
cord-002407-25cawzi0	416	59	cold	cold	NN
cord-002407-25cawzi0	416	60	-	-	HYPH
cord-002407-25cawzi0	416	61	adapted	adapt	VBN
cord-002407-25cawzi0	416	62	B	B	NNP
cord-002407-25cawzi0	416	63	/	/	SYM
cord-002407-25cawzi0	416	64	Ann	Ann	NNP
cord-002407-25cawzi0	416	65	Arbor/1/66	Arbor/1/66	NNP
cord-002407-25cawzi0	416	66	influenza	influenza	NN
cord-002407-25cawzi0	416	67	virus	virus	NN
cord-002407-25cawzi0	416	68	genes	gene	NNS
cord-002407-25cawzi0	416	69	Genetics	Genetics	NNPS
cord-002407-25cawzi0	416	70	of	of	IN
cord-002407-25cawzi0	416	71	cold	cold	NN
cord-002407-25cawzi0	416	72	-	-	HYPH
cord-002407-25cawzi0	416	73	adapted	adapt	VBN
cord-002407-25cawzi0	416	74	B	B	NNP
cord-002407-25cawzi0	416	75	/	/	SYM
cord-002407-25cawzi0	416	76	Ann	Ann	NNP
cord-002407-25cawzi0	416	77	Arbor/1/66	Arbor/1/66	NNP
cord-002407-25cawzi0	416	78	influenza	influenza	NN
cord-002407-25cawzi0	416	79	virus	virus	NN
cord-002407-25cawzi0	416	80	reassortants	reassortant	NNS
cord-002407-25cawzi0	416	81	:	:	:
cord-002407-25cawzi0	416	82	The	the	DT
cord-002407-25cawzi0	416	83	acidic	acidic	JJ
cord-002407-25cawzi0	416	84	polymerase	polymerase	NN
cord-002407-25cawzi0	416	85	(	(	-LRB-
cord-002407-25cawzi0	416	86	PA	PA	NNP
cord-002407-25cawzi0	416	87	)	)	-RRB-
cord-002407-25cawzi0	416	88	protein	protein	NN
cord-002407-25cawzi0	416	89	gene	gene	NN
cord-002407-25cawzi0	416	90	confers	confer	VBZ
cord-002407-25cawzi0	416	91	temperature	temperature	NN
cord-002407-25cawzi0	416	92	sensitivity	sensitivity	NN
cord-002407-25cawzi0	416	93	and	and	CC
cord-002407-25cawzi0	416	94	attenuated	attenuated	JJ
cord-002407-25cawzi0	416	95	virulence	virulence	NN
cord-002407-25cawzi0	416	96	The	the	DT
cord-002407-25cawzi0	416	97	cold	cold	NN
cord-002407-25cawzi0	416	98	adapted	adapt	VBN
cord-002407-25cawzi0	416	99	and	and	CC
cord-002407-25cawzi0	416	100	temperature	temperature	NN
cord-002407-25cawzi0	416	101	sensitive	sensitive	JJ
cord-002407-25cawzi0	416	102	influenza	influenza	NN
cord-002407-25cawzi0	416	103	A	A	NNP
cord-002407-25cawzi0	416	104	/	/	SYM
cord-002407-25cawzi0	416	105	Ann	Ann	NNP
cord-002407-25cawzi0	416	106	Arbor/6/60	Arbor/6/60	NNP
cord-002407-25cawzi0	416	107	virus	virus	NN
cord-002407-25cawzi0	416	108	,	,	,
cord-002407-25cawzi0	416	109	the	the	DT
cord-002407-25cawzi0	416	110	master	master	NN
cord-002407-25cawzi0	416	111	donor	donor	NN
cord-002407-25cawzi0	416	112	virus	virus	NN
cord-002407-25cawzi0	416	113	for	for	IN
cord-002407-25cawzi0	416	114	live	live	RB
cord-002407-25cawzi0	416	115	-	-	HYPH
cord-002407-25cawzi0	416	116	attenuated	attenuate	VBN
cord-002407-25cawzi0	416	117	influenza	influenza	NN
cord-002407-25cawzi0	416	118	vaccines	vaccine	NNS
cord-002407-25cawzi0	416	119	,	,	,
cord-002407-25cawzi0	416	120	has	have	VBZ
cord-002407-25cawzi0	416	121	multiple	multiple	JJ
cord-002407-25cawzi0	416	122	defects	defect	NNS
cord-002407-25cawzi0	416	123	in	in	IN
cord-002407-25cawzi0	416	124	replication	replication	NN
cord-002407-25cawzi0	416	125	at	at	IN
cord-002407-25cawzi0	416	126	the	the	DT
cord-002407-25cawzi0	416	127	restrictive	restrictive	JJ
cord-002407-25cawzi0	416	128	temperature	temperature	NN
cord-002407-25cawzi0	417	1	Imparting	impart	VBG
cord-002407-25cawzi0	417	2	temperature	temperature	NN
cord-002407-25cawzi0	417	3	sensitivity	sensitivity	NN
cord-002407-25cawzi0	417	4	and	and	CC
cord-002407-25cawzi0	417	5	attenuation	attenuation	NN
cord-002407-25cawzi0	417	6	in	in	IN
cord-002407-25cawzi0	417	7	ferrets	ferret	NNS
cord-002407-25cawzi0	417	8	to	to	IN
cord-002407-25cawzi0	417	9	A	a	DT
cord-002407-25cawzi0	417	10	/	/	SYM
cord-002407-25cawzi0	417	11	Puerto	Puerto	NNP
cord-002407-25cawzi0	417	12	Rico/8/34	Rico/8/34	NNP
cord-002407-25cawzi0	417	13	influenza	influenza	NN
cord-002407-25cawzi0	417	14	virus	virus	NN
cord-002407-25cawzi0	417	15	by	by	IN
cord-002407-25cawzi0	417	16	transferring	transfer	VBG
cord-002407-25cawzi0	417	17	the	the	DT
cord-002407-25cawzi0	417	18	genetic	genetic	JJ
cord-002407-25cawzi0	417	19	signature	signature	NN
cord-002407-25cawzi0	417	20	for	for	IN
cord-002407-25cawzi0	417	21	temperature	temperature	NN
cord-002407-25cawzi0	417	22	sensitivity	sensitivity	NN
cord-002407-25cawzi0	417	23	from	from	IN
cord-002407-25cawzi0	417	24	cold	cold	NN
cord-002407-25cawzi0	417	25	-	-	HYPH
cord-002407-25cawzi0	417	26	adapted	adapt	VBN
cord-002407-25cawzi0	417	27	A	A	NNP
cord-002407-25cawzi0	417	28	/	/	SYM
cord-002407-25cawzi0	417	29	Ann	Ann	NNP
cord-002407-25cawzi0	417	30	Arbor/6/60	arbor/6/60	CD
cord-002407-25cawzi0	417	31	Multiple	multiple	JJ
cord-002407-25cawzi0	417	32	amino	amino	NN
cord-002407-25cawzi0	417	33	acid	acid	NN
cord-002407-25cawzi0	417	34	residues	residue	NNS
cord-002407-25cawzi0	417	35	confer	confer	VBP
cord-002407-25cawzi0	417	36	temperature	temperature	NN
cord-002407-25cawzi0	417	37	sensitivity	sensitivity	NN
cord-002407-25cawzi0	417	38	to	to	IN
cord-002407-25cawzi0	417	39	human	human	JJ
cord-002407-25cawzi0	417	40	influenza	influenza	NN
cord-002407-25cawzi0	417	41	virus	virus	NN
cord-002407-25cawzi0	417	42	vaccine	vaccine	NN
cord-002407-25cawzi0	417	43	strains	strain	NNS
cord-002407-25cawzi0	417	44	(	(	-LRB-
cord-002407-25cawzi0	417	45	flumist	flumist	NNP
cord-002407-25cawzi0	417	46	)	)	-RRB-
cord-002407-25cawzi0	417	47	derived	derive	VBN
cord-002407-25cawzi0	417	48	from	from	IN
cord-002407-25cawzi0	417	49	cold	cold	NN
cord-002407-25cawzi0	417	50	-	-	HYPH
cord-002407-25cawzi0	417	51	adapted	adapt	VBN
cord-002407-25cawzi0	417	52	A	A	NNP
cord-002407-25cawzi0	417	53	/	/	SYM
cord-002407-25cawzi0	417	54	Ann	Ann	NNP
cord-002407-25cawzi0	417	55	Arbor/6/60	Arbor/6/60	NNP
cord-002407-25cawzi0	417	56	Adaptation	Adaptation	NNP
cord-002407-25cawzi0	417	57	and	and	CC
cord-002407-25cawzi0	417	58	growth	growth	NN
cord-002407-25cawzi0	417	59	characteristics	characteristic	NNS
cord-002407-25cawzi0	417	60	of	of	IN
cord-002407-25cawzi0	417	61	influenza	influenza	NN
cord-002407-25cawzi0	417	62	virus	virus	NN
cord-002407-25cawzi0	417	63	at	at	IN
cord-002407-25cawzi0	417	64	25	25	CD
cord-002407-25cawzi0	417	65	•	•	NNS
cord-002407-25cawzi0	417	66	C	C	NNP
cord-002407-25cawzi0	417	67	Development	Development	NNP
cord-002407-25cawzi0	417	68	of	of	IN
cord-002407-25cawzi0	417	69	a	a	DT
cord-002407-25cawzi0	417	70	mouse	mouse	NN
cord-002407-25cawzi0	417	71	-	-	HYPH
cord-002407-25cawzi0	417	72	adapted	adapt	VBN
cord-002407-25cawzi0	417	73	live	live	RB
cord-002407-25cawzi0	417	74	-	-	HYPH
cord-002407-25cawzi0	417	75	attenuated	attenuate	VBN
cord-002407-25cawzi0	417	76	influenza	influenza	NN
cord-002407-25cawzi0	417	77	virus	virus	NN
cord-002407-25cawzi0	417	78	that	that	WDT
cord-002407-25cawzi0	417	79	permits	permit	VBZ
cord-002407-25cawzi0	417	80	in	in	IN
cord-002407-25cawzi0	417	81	vivo	vivo	NN
cord-002407-25cawzi0	417	82	analysis	analysis	NN
cord-002407-25cawzi0	417	83	of	of	IN
cord-002407-25cawzi0	417	84	enhancements	enhancement	NNS
cord-002407-25cawzi0	417	85	to	to	IN
cord-002407-25cawzi0	417	86	the	the	DT
cord-002407-25cawzi0	417	87	safety	safety	NN
cord-002407-25cawzi0	417	88	of	of	IN
cord-002407-25cawzi0	417	89	live	live	RB
cord-002407-25cawzi0	417	90	-	-	HYPH
cord-002407-25cawzi0	417	91	attenuated	attenuate	VBN
cord-002407-25cawzi0	417	92	influenza	influenza	NN
cord-002407-25cawzi0	417	93	virus	virus	NN
cord-002407-25cawzi0	417	94	vaccine	vaccine	NN
cord-002407-25cawzi0	417	95	Influenza	Influenza	NNP
cord-002407-25cawzi0	417	96	vaccination	vaccination	NN
cord-002407-25cawzi0	417	97	in	in	IN
cord-002407-25cawzi0	417	98	asthmatic	asthmatic	JJ
cord-002407-25cawzi0	417	99	patients	patient	NNS
cord-002407-25cawzi0	417	100	Safety	Safety	NNP
cord-002407-25cawzi0	417	101	,	,	,
cord-002407-25cawzi0	417	102	efficacy	efficacy	NN
cord-002407-25cawzi0	417	103	and	and	CC
cord-002407-25cawzi0	417	104	effectiveness	effectiveness	NN
cord-002407-25cawzi0	417	105	of	of	IN
cord-002407-25cawzi0	417	106	cold	cold	NN
cord-002407-25cawzi0	417	107	-	-	HYPH
cord-002407-25cawzi0	417	108	adapted	adapt	VBN
cord-002407-25cawzi0	417	109	,	,	,
cord-002407-25cawzi0	417	110	live	live	JJ
cord-002407-25cawzi0	417	111	,	,	,
cord-002407-25cawzi0	417	112	attenuated	attenuated	JJ
cord-002407-25cawzi0	417	113	,	,	,
cord-002407-25cawzi0	417	114	trivalent	trivalent	JJ
cord-002407-25cawzi0	417	115	,	,	,
cord-002407-25cawzi0	417	116	intranasal	intranasal	NN
cord-002407-25cawzi0	417	117	influenza	influenza	NN
cord-002407-25cawzi0	417	118	vaccine	vaccine	NN
cord-002407-25cawzi0	417	119	in	in	IN
cord-002407-25cawzi0	417	120	adults	adult	NNS
cord-002407-25cawzi0	417	121	and	and	CC
cord-002407-25cawzi0	417	122	children	child	NNS
cord-002407-25cawzi0	418	1	Recombinant	recombinant	JJ
cord-002407-25cawzi0	418	2	cold	cold	RB
cord-002407-25cawzi0	418	3	-	-	HYPH
cord-002407-25cawzi0	418	4	adapted	adapt	VBN
cord-002407-25cawzi0	418	5	attenuated	attenuated	JJ
cord-002407-25cawzi0	418	6	influenza	influenza	NN
cord-002407-25cawzi0	418	7	A	a	DT
cord-002407-25cawzi0	418	8	vaccines	vaccine	NNS
cord-002407-25cawzi0	418	9	for	for	IN
cord-002407-25cawzi0	418	10	use	use	NN
cord-002407-25cawzi0	418	11	in	in	IN
cord-002407-25cawzi0	418	12	children	child	NNS
cord-002407-25cawzi0	418	13	:	:	:
cord-002407-25cawzi0	419	1	Molecular	molecular	JJ
cord-002407-25cawzi0	419	2	genetic	genetic	JJ
cord-002407-25cawzi0	419	3	analysis	analysis	NN
cord-002407-25cawzi0	419	4	of	of	IN
cord-002407-25cawzi0	419	5	the	the	DT
cord-002407-25cawzi0	419	6	cold	cold	RB
cord-002407-25cawzi0	419	7	-	-	HYPH
cord-002407-25cawzi0	419	8	adapted	adapt	VBN
cord-002407-25cawzi0	419	9	donor	donor	NN
cord-002407-25cawzi0	419	10	and	and	CC
cord-002407-25cawzi0	419	11	recombinants	recombinant	NNS
cord-002407-25cawzi0	419	12	Molecular	molecular	JJ
cord-002407-25cawzi0	419	13	characteristics	characteristic	NNS
cord-002407-25cawzi0	419	14	and	and	CC
cord-002407-25cawzi0	419	15	biological	biological	JJ
cord-002407-25cawzi0	419	16	properties	property	NNS
cord-002407-25cawzi0	419	17	(	(	-LRB-
cord-002407-25cawzi0	419	18	genetic	genetic	JJ
cord-002407-25cawzi0	419	19	markers	marker	NNS
cord-002407-25cawzi0	419	20	)	)	-RRB-
cord-002407-25cawzi0	419	21	of	of	IN
cord-002407-25cawzi0	419	22	candidate	candidate	NN
cord-002407-25cawzi0	419	23	strains	strain	NNS
cord-002407-25cawzi0	419	24	for	for	IN
cord-002407-25cawzi0	419	25	preparation	preparation	NN
cord-002407-25cawzi0	419	26	of	of	IN
cord-002407-25cawzi0	419	27	live	live	JJ
cord-002407-25cawzi0	419	28	influenza	influenza	NN
cord-002407-25cawzi0	419	29	virus	virus	NN
cord-002407-25cawzi0	419	30	vaccines	vaccine	NNS
cord-002407-25cawzi0	419	31	Genetic	genetic	JJ
cord-002407-25cawzi0	419	32	bases	basis	NNS
cord-002407-25cawzi0	419	33	of	of	IN
cord-002407-25cawzi0	419	34	the	the	DT
cord-002407-25cawzi0	419	35	temperature	temperature	NN
cord-002407-25cawzi0	419	36	-	-	HYPH
cord-002407-25cawzi0	419	37	sensitive	sensitive	JJ
cord-002407-25cawzi0	419	38	phenotype	phenotype	NN
cord-002407-25cawzi0	419	39	of	of	IN
cord-002407-25cawzi0	419	40	a	a	DT
cord-002407-25cawzi0	419	41	master	master	NN
cord-002407-25cawzi0	419	42	donor	donor	NN
cord-002407-25cawzi0	419	43	virus	virus	NN
cord-002407-25cawzi0	419	44	used	use	VBN
cord-002407-25cawzi0	419	45	in	in	IN
cord-002407-25cawzi0	419	46	live	live	RB
cord-002407-25cawzi0	419	47	-	-	HYPH
cord-002407-25cawzi0	419	48	attenuated	attenuate	VBN
cord-002407-25cawzi0	419	49	influenza	influenza	NN
cord-002407-25cawzi0	419	50	vaccines	vaccine	NNS
cord-002407-25cawzi0	419	51	:	:	:
cord-002407-25cawzi0	420	1	A	a	LS
cord-002407-25cawzi0	420	2	/	/	SYM
cord-002407-25cawzi0	420	3	Leningrad/134/17/57	leningrad/134/17/57	XX
cord-002407-25cawzi0	421	1	(	(	-LRB-
cord-002407-25cawzi0	421	2	H2N2	H2N2	NNP
cord-002407-25cawzi0	421	3	)	)	-RRB-
cord-002407-25cawzi0	421	4	Cold	Cold	NNP
cord-002407-25cawzi0	421	5	-	-	HYPH
cord-002407-25cawzi0	421	6	adapted	adapt	VBN
cord-002407-25cawzi0	421	7	live	live	RB
cord-002407-25cawzi0	421	8	-	-	HYPH
cord-002407-25cawzi0	421	9	attenuated	attenuate	VBN
cord-002407-25cawzi0	421	10	influenza	influenza	NN
cord-002407-25cawzi0	421	11	vaccines	vaccine	NNS
cord-002407-25cawzi0	421	12	developed	develop	VBN
cord-002407-25cawzi0	421	13	in	in	IN
cord-002407-25cawzi0	421	14	russia	russia	NNP
cord-002407-25cawzi0	421	15	:	:	:
cord-002407-25cawzi0	421	16	Can	Can	MD
cord-002407-25cawzi0	421	17	they	-PRON-	PRP
cord-002407-25cawzi0	421	18	contribute	contribute	VB
cord-002407-25cawzi0	421	19	to	to	IN
cord-002407-25cawzi0	421	20	meeting	meet	VBG
cord-002407-25cawzi0	421	21	the	the	DT
cord-002407-25cawzi0	421	22	needs	need	NNS
cord-002407-25cawzi0	421	23	for	for	IN
cord-002407-25cawzi0	421	24	influenza	influenza	NN
cord-002407-25cawzi0	421	25	control	control	NN
cord-002407-25cawzi0	421	26	in	in	IN
cord-002407-25cawzi0	421	27	other	other	JJ
cord-002407-25cawzi0	421	28	countries	country	NNS
cord-002407-25cawzi0	421	29	?	?	.
cord-002407-25cawzi0	422	1	Comparison	comparison	NN
cord-002407-25cawzi0	422	2	of	of	IN
cord-002407-25cawzi0	422	3	egg	egg	NN
cord-002407-25cawzi0	422	4	and	and	CC
cord-002407-25cawzi0	422	5	high	high	JJ
cord-002407-25cawzi0	422	6	yielding	yield	VBG
cord-002407-25cawzi0	422	7	MDCK	MDCK	NNP
cord-002407-25cawzi0	422	8	cell	cell	NN
cord-002407-25cawzi0	422	9	-	-	HYPH
cord-002407-25cawzi0	422	10	derived	derive	VBN
cord-002407-25cawzi0	422	11	live	live	RB
cord-002407-25cawzi0	422	12	-	-	HYPH
cord-002407-25cawzi0	422	13	attenuated	attenuate	VBN
cord-002407-25cawzi0	422	14	influenza	influenza	NN
cord-002407-25cawzi0	422	15	virus	virus	NN
cord-002407-25cawzi0	422	16	for	for	IN
cord-002407-25cawzi0	422	17	commercial	commercial	JJ
cord-002407-25cawzi0	422	18	production	production	NN
cord-002407-25cawzi0	422	19	of	of	IN
cord-002407-25cawzi0	422	20	trivalent	trivalent	JJ
cord-002407-25cawzi0	422	21	influenza	influenza	NN
cord-002407-25cawzi0	422	22	vaccine	vaccine	NN
cord-002407-25cawzi0	422	23	:	:	:
cord-002407-25cawzi0	423	1	In	in	IN
cord-002407-25cawzi0	423	2	vitro	vitro	FW
cord-002407-25cawzi0	423	3	cell	cell	NN
cord-002407-25cawzi0	423	4	susceptibility	susceptibility	NN
cord-002407-25cawzi0	423	5	and	and	CC
cord-002407-25cawzi0	423	6	influenza	influenza	NN
cord-002407-25cawzi0	423	7	virus	virus	NN
cord-002407-25cawzi0	423	8	replication	replication	NN
cord-002407-25cawzi0	423	9	kinetics	kinetic	NNS
cord-002407-25cawzi0	423	10	in	in	IN
cord-002407-25cawzi0	423	11	permissive	permissive	JJ
cord-002407-25cawzi0	423	12	and	and	CC
cord-002407-25cawzi0	423	13	semi	semi	JJ
cord-002407-25cawzi0	423	14	-	-	JJ
cord-002407-25cawzi0	423	15	permissive	permissive	JJ
cord-002407-25cawzi0	423	16	cells	cell	NNS
cord-002407-25cawzi0	423	17	Generation	generation	NN
cord-002407-25cawzi0	423	18	of	of	IN
cord-002407-25cawzi0	423	19	live	live	RB
cord-002407-25cawzi0	423	20	-	-	HYPH
cord-002407-25cawzi0	423	21	attenuated	attenuate	VBN
cord-002407-25cawzi0	423	22	novel	novel	JJ
cord-002407-25cawzi0	423	23	influenza	influenza	NN
cord-002407-25cawzi0	423	24	virus	virus	NN
cord-002407-25cawzi0	424	1	A	a	LS
cord-002407-25cawzi0	424	2	/	/	,
cord-002407-25cawzi0	424	3	California/7/09	California/7/09	,
cord-002407-25cawzi0	424	4	(	(	-LRB-
cord-002407-25cawzi0	424	5	H1N1	H1N1	NNP
cord-002407-25cawzi0	424	6	)	)	-RRB-
cord-002407-25cawzi0	424	7	vaccines	vaccine	NNS
cord-002407-25cawzi0	424	8	with	with	IN
cord-002407-25cawzi0	424	9	high	high	JJ
cord-002407-25cawzi0	424	10	yield	yield	NN
cord-002407-25cawzi0	424	11	in	in	IN
cord-002407-25cawzi0	424	12	embryonated	embryonate	VBN
cord-002407-25cawzi0	424	13	chicken	chicken	NN
cord-002407-25cawzi0	424	14	eggs	egg	NNS
cord-002407-25cawzi0	424	15	Distribution	distribution	NN
cord-002407-25cawzi0	424	16	of	of	IN
cord-002407-25cawzi0	424	17	influenza	influenza	NN
cord-002407-25cawzi0	424	18	virus	virus	NN
cord-002407-25cawzi0	424	19	type	type	NN
cord-002407-25cawzi0	424	20	a	a	DT
cord-002407-25cawzi0	424	21	in	in	IN
cord-002407-25cawzi0	424	22	infected	infected	JJ
cord-002407-25cawzi0	424	23	eggs	egg	NNS
cord-002407-25cawzi0	424	24	and	and	CC
cord-002407-25cawzi0	424	25	the	the	DT
cord-002407-25cawzi0	424	26	survival	survival	NN
cord-002407-25cawzi0	424	27	of	of	IN
cord-002407-25cawzi0	424	28	virus	virus	NN
cord-002407-25cawzi0	424	29	under	under	IN
cord-002407-25cawzi0	424	30	certain	certain	JJ
cord-002407-25cawzi0	424	31	conditions	condition	NNS
cord-002407-25cawzi0	424	32	of	of	IN
cord-002407-25cawzi0	424	33	storage	storage	NN
cord-002407-25cawzi0	424	34	A	a	DT
cord-002407-25cawzi0	424	35	flu	flu	NN
cord-002407-25cawzi0	424	36	vaccine	vaccine	NN
cord-002407-25cawzi0	424	37	shortage	shortage	NN
cord-002407-25cawzi0	424	38	can	can	MD
cord-002407-25cawzi0	424	39	be	be	VB
cord-002407-25cawzi0	424	40	devastating	devastating	JJ
cord-002407-25cawzi0	424	41	for	for	IN
cord-002407-25cawzi0	424	42	LTC	LTC	NNP
cord-002407-25cawzi0	424	43	residents	resident	NNS
cord-002407-25cawzi0	425	1	The	the	DT
cord-002407-25cawzi0	425	2	politics	politic	NNS
cord-002407-25cawzi0	425	3	of	of	IN
cord-002407-25cawzi0	425	4	the	the	DT
cord-002407-25cawzi0	425	5	flu	flu	NN
cord-002407-25cawzi0	425	6	vaccine	vaccine	NN
cord-002407-25cawzi0	425	7	shortage	shortage	NN
cord-002407-25cawzi0	425	8	Continuous	continuous	JJ
cord-002407-25cawzi0	425	9	cell	cell	NN
cord-002407-25cawzi0	425	10	lines	line	NNS
cord-002407-25cawzi0	425	11	as	as	IN
cord-002407-25cawzi0	425	12	a	a	DT
cord-002407-25cawzi0	425	13	production	production	NN
cord-002407-25cawzi0	425	14	system	system	NN
cord-002407-25cawzi0	425	15	for	for	IN
cord-002407-25cawzi0	425	16	influenza	influenza	NN
cord-002407-25cawzi0	425	17	vaccines	vaccine	NNS
cord-002407-25cawzi0	425	18	Scalable	scalable	JJ
cord-002407-25cawzi0	425	19	production	production	NN
cord-002407-25cawzi0	425	20	of	of	IN
cord-002407-25cawzi0	425	21	influenza	influenza	NN
cord-002407-25cawzi0	425	22	virus	virus	NN
cord-002407-25cawzi0	425	23	in	in	IN
cord-002407-25cawzi0	425	24	HEK-293	HEK-293	NNP
cord-002407-25cawzi0	425	25	cells	cell	NNS
cord-002407-25cawzi0	425	26	for	for	IN
cord-002407-25cawzi0	425	27	efficient	efficient	JJ
cord-002407-25cawzi0	425	28	vaccine	vaccine	NN
cord-002407-25cawzi0	425	29	manufacturing	manufacture	VBG
cord-002407-25cawzi0	425	30	Production	production	NN
cord-002407-25cawzi0	425	31	of	of	IN
cord-002407-25cawzi0	425	32	influenza	influenza	NN
cord-002407-25cawzi0	425	33	virus	virus	NN
cord-002407-25cawzi0	425	34	in	in	IN
cord-002407-25cawzi0	425	35	serum	serum	NN
cord-002407-25cawzi0	425	36	-	-	HYPH
cord-002407-25cawzi0	425	37	free	free	JJ
cord-002407-25cawzi0	425	38	mammalian	mammalian	JJ
cord-002407-25cawzi0	425	39	cell	cell	NN
cord-002407-25cawzi0	425	40	cultures	culture	NNS
cord-002407-25cawzi0	425	41	Production	production	NN
cord-002407-25cawzi0	425	42	of	of	IN
cord-002407-25cawzi0	425	43	influenza	influenza	NN
cord-002407-25cawzi0	425	44	virus	virus	NN
cord-002407-25cawzi0	425	45	in	in	IN
cord-002407-25cawzi0	425	46	cell	cell	NN
cord-002407-25cawzi0	425	47	cultures	culture	NNS
cord-002407-25cawzi0	425	48	for	for	IN
cord-002407-25cawzi0	425	49	vaccine	vaccine	NN
cord-002407-25cawzi0	425	50	preparation	preparation	NN
cord-002407-25cawzi0	426	1	Inactivated	inactivate	VBN
cord-002407-25cawzi0	426	2	and	and	CC
cord-002407-25cawzi0	426	3	adjuvanted	adjuvante	VBN
cord-002407-25cawzi0	426	4	influenza	influenza	NN
cord-002407-25cawzi0	426	5	vaccines	vaccine	NNS
cord-002407-25cawzi0	426	6	Safety	Safety	NNP
cord-002407-25cawzi0	426	7	and	and	CC
cord-002407-25cawzi0	426	8	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	426	9	of	of	IN
cord-002407-25cawzi0	426	10	adjuvanted	adjuvanted	JJ
cord-002407-25cawzi0	426	11	inactivated	inactivated	JJ
cord-002407-25cawzi0	426	12	split	split	NN
cord-002407-25cawzi0	426	13	-	-	HYPH
cord-002407-25cawzi0	426	14	virion	virion	NN
cord-002407-25cawzi0	426	15	and	and	CC
cord-002407-25cawzi0	426	16	whole	whole	JJ
cord-002407-25cawzi0	426	17	-	-	HYPH
cord-002407-25cawzi0	426	18	virion	virion	NN
cord-002407-25cawzi0	426	19	influenza	influenza	NN
cord-002407-25cawzi0	426	20	A	a	NN
cord-002407-25cawzi0	426	21	(	(	-LRB-
cord-002407-25cawzi0	426	22	H5N1	H5N1	NNP
cord-002407-25cawzi0	426	23	)	)	-RRB-
cord-002407-25cawzi0	426	24	vaccines	vaccine	NNS
cord-002407-25cawzi0	426	25	in	in	IN
cord-002407-25cawzi0	426	26	children	child	NNS
cord-002407-25cawzi0	426	27	:	:	:
cord-002407-25cawzi0	426	28	A	a	DT
cord-002407-25cawzi0	426	29	phase	phase	NN
cord-002407-25cawzi0	426	30	I	I	NNP
cord-002407-25cawzi0	426	31	-	-	HYPH
cord-002407-25cawzi0	426	32	II	II	NNP
cord-002407-25cawzi0	426	33	randomized	randomized	JJ
cord-002407-25cawzi0	426	34	trial	trial	NN
cord-002407-25cawzi0	426	35	Safety	safety	NN
cord-002407-25cawzi0	426	36	and	and	CC
cord-002407-25cawzi0	426	37	effectiveness	effectiveness	NN
cord-002407-25cawzi0	426	38	of	of	IN
cord-002407-25cawzi0	426	39	MF-59	MF-59	NNP
cord-002407-25cawzi0	426	40	adjuvanted	adjuvante	VBN
cord-002407-25cawzi0	426	41	influenza	influenza	NN
cord-002407-25cawzi0	426	42	vaccines	vaccine	NNS
cord-002407-25cawzi0	426	43	in	in	IN
cord-002407-25cawzi0	426	44	children	child	NNS
cord-002407-25cawzi0	426	45	and	and	CC
cord-002407-25cawzi0	426	46	adults	adult	NNS
cord-002407-25cawzi0	426	47	Persistence	Persistence	NNP
cord-002407-25cawzi0	426	48	of	of	IN
cord-002407-25cawzi0	426	49	antibody	antibody	NN
cord-002407-25cawzi0	426	50	to	to	TO
cord-002407-25cawzi0	426	51	influenza	influenza	VB
cord-002407-25cawzi0	426	52	A	A	NNP
cord-002407-25cawzi0	426	53	/	/	SYM
cord-002407-25cawzi0	426	54	H5N1	H5N1	NNP
cord-002407-25cawzi0	426	55	vaccine	vaccine	NN
cord-002407-25cawzi0	426	56	virus	virus	NN
cord-002407-25cawzi0	426	57	:	:	:
cord-002407-25cawzi0	426	58	Impact	impact	NN
cord-002407-25cawzi0	426	59	of	of	IN
cord-002407-25cawzi0	426	60	AS03	AS03	NNP
cord-002407-25cawzi0	426	61	adjuvant	adjuvant	JJ
cord-002407-25cawzi0	426	62	RNA	RNA	NNP
cord-002407-25cawzi0	426	63	virus	virus	NN
cord-002407-25cawzi0	426	64	reverse	reverse	NN
cord-002407-25cawzi0	426	65	genetics	genetic	NNS
cord-002407-25cawzi0	426	66	and	and	CC
cord-002407-25cawzi0	426	67	vaccine	vaccine	NN
cord-002407-25cawzi0	426	68	design	design	NN
cord-002407-25cawzi0	426	69	Engineering	engineering	NN
cord-002407-25cawzi0	426	70	infectious	infectious	JJ
cord-002407-25cawzi0	426	71	cDNAs	cdna	NNS
cord-002407-25cawzi0	426	72	of	of	IN
cord-002407-25cawzi0	426	73	coronavirus	coronavirus	NN
cord-002407-25cawzi0	426	74	as	as	IN
cord-002407-25cawzi0	426	75	bacterial	bacterial	JJ
cord-002407-25cawzi0	426	76	artificial	artificial	JJ
cord-002407-25cawzi0	426	77	chromosomes	chromosome	NNS
cord-002407-25cawzi0	426	78	Construction	construction	NN
cord-002407-25cawzi0	426	79	of	of	IN
cord-002407-25cawzi0	426	80	a	a	DT
cord-002407-25cawzi0	426	81	severe	severe	JJ
cord-002407-25cawzi0	426	82	acute	acute	JJ
cord-002407-25cawzi0	426	83	respiratory	respiratory	JJ
cord-002407-25cawzi0	426	84	syndrome	syndrome	NN
cord-002407-25cawzi0	426	85	coronavirus	coronavirus	NN
cord-002407-25cawzi0	426	86	infectious	infectious	JJ
cord-002407-25cawzi0	426	87	cDNA	cdna	NN
cord-002407-25cawzi0	426	88	clone	clone	NN
cord-002407-25cawzi0	426	89	and	and	CC
cord-002407-25cawzi0	426	90	a	a	DT
cord-002407-25cawzi0	426	91	replicon	replicon	NN
cord-002407-25cawzi0	426	92	to	to	TO
cord-002407-25cawzi0	426	93	study	study	VB
cord-002407-25cawzi0	426	94	coronavirus	coronavirus	NN
cord-002407-25cawzi0	426	95	RNA	RNA	NNP
cord-002407-25cawzi0	426	96	synthesis	synthesis	NN
cord-002407-25cawzi0	427	1	Cloned	clone	VBN
cord-002407-25cawzi0	427	2	poliovirus	poliovirus	NN
cord-002407-25cawzi0	427	3	complementary	complementary	JJ
cord-002407-25cawzi0	427	4	DNA	dna	NN
cord-002407-25cawzi0	427	5	is	be	VBZ
cord-002407-25cawzi0	427	6	infectious	infectious	JJ
cord-002407-25cawzi0	427	7	in	in	IN
cord-002407-25cawzi0	427	8	mammalian	mammalian	JJ
cord-002407-25cawzi0	427	9	cells	cell	NNS
cord-002407-25cawzi0	427	10	Generation	generation	NN
cord-002407-25cawzi0	427	11	of	of	IN
cord-002407-25cawzi0	427	12	recombinant	recombinant	JJ
cord-002407-25cawzi0	427	13	influenza	influenza	NN
cord-002407-25cawzi0	427	14	virus	virus	NN
cord-002407-25cawzi0	427	15	from	from	IN
cord-002407-25cawzi0	427	16	plasmid	plasmid	NN
cord-002407-25cawzi0	427	17	DNA	DNA	NNP
cord-002407-25cawzi0	427	18	Many	many	JJ
cord-002407-25cawzi0	427	19	ways	way	NNS
cord-002407-25cawzi0	427	20	to	to	TO
cord-002407-25cawzi0	427	21	make	make	VB
cord-002407-25cawzi0	427	22	an	an	DT
cord-002407-25cawzi0	427	23	influenza	influenza	NN
cord-002407-25cawzi0	427	24	virus	virus	NN
cord-002407-25cawzi0	427	25	-	-	:
cord-002407-25cawzi0	427	26	Review	Review	NNP
cord-002407-25cawzi0	427	27	of	of	IN
cord-002407-25cawzi0	427	28	influenza	influenza	NN
cord-002407-25cawzi0	427	29	virus	virus	NN
cord-002407-25cawzi0	427	30	reverse	reverse	NN
cord-002407-25cawzi0	427	31	genetics	genetics	NN
cord-002407-25cawzi0	427	32	methods	method	NNS
cord-002407-25cawzi0	427	33	.	.	.
cord-002407-25cawzi0	428	1	Influenza	Influenza	NNP
cord-002407-25cawzi0	428	2	Other	other	JJ
cord-002407-25cawzi0	428	3	Respir	Respir	NNP
cord-002407-25cawzi0	428	4	.	.	.
cord-002407-25cawzi0	429	1	Viruses	virus	NNS
cord-002407-25cawzi0	430	1	Influenza	influenza	NN
cord-002407-25cawzi0	431	1	a	a	DT
cord-002407-25cawzi0	431	2	virus	virus	NN
cord-002407-25cawzi0	431	3	attenuation	attenuation	NN
cord-002407-25cawzi0	431	4	by	by	IN
cord-002407-25cawzi0	431	5	codon	codon	NN
cord-002407-25cawzi0	431	6	deoptimization	deoptimization	NN
cord-002407-25cawzi0	431	7	of	of	IN
cord-002407-25cawzi0	431	8	the	the	DT
cord-002407-25cawzi0	431	9	NS	NS	NNP
cord-002407-25cawzi0	431	10	gene	gene	NN
cord-002407-25cawzi0	431	11	for	for	IN
cord-002407-25cawzi0	431	12	vaccine	vaccine	NN
cord-002407-25cawzi0	431	13	development	development	NN
cord-002407-25cawzi0	431	14	Replication	replication	NN
cord-002407-25cawzi0	431	15	-	-	HYPH
cord-002407-25cawzi0	431	16	competent	competent	JJ
cord-002407-25cawzi0	431	17	influenza	influenza	NN
cord-002407-25cawzi0	431	18	A	a	DT
cord-002407-25cawzi0	431	19	viruses	virus	NNS
cord-002407-25cawzi0	431	20	expressing	express	VBG
cord-002407-25cawzi0	431	21	a	a	DT
cord-002407-25cawzi0	431	22	red	red	JJ
cord-002407-25cawzi0	431	23	fluorescent	fluorescent	NN
cord-002407-25cawzi0	431	24	protein	protein	NN
cord-002407-25cawzi0	431	25	Hemagglutinin	Hemagglutinin	NNP
cord-002407-25cawzi0	431	26	-	-	HYPH
cord-002407-25cawzi0	431	27	pseudotyped	pseudotype	VBN
cord-002407-25cawzi0	431	28	green	green	JJ
cord-002407-25cawzi0	431	29	fluorescent	fluorescent	NN
cord-002407-25cawzi0	431	30	protein	protein	NN
cord-002407-25cawzi0	431	31	-	-	HYPH
cord-002407-25cawzi0	431	32	expressing	express	VBG
cord-002407-25cawzi0	431	33	influenza	influenza	NN
cord-002407-25cawzi0	431	34	viruses	virus	NNS
cord-002407-25cawzi0	431	35	for	for	IN
cord-002407-25cawzi0	431	36	the	the	DT
cord-002407-25cawzi0	431	37	detection	detection	NN
cord-002407-25cawzi0	431	38	of	of	IN
cord-002407-25cawzi0	431	39	influenza	influenza	NN
cord-002407-25cawzi0	431	40	virus	virus	NN
cord-002407-25cawzi0	431	41	neutralizing	neutralize	VBG
cord-002407-25cawzi0	431	42	antibodies	antibody	NNS
cord-002407-25cawzi0	431	43	Development	Development	NNP
cord-002407-25cawzi0	431	44	and	and	CC
cord-002407-25cawzi0	431	45	applications	application	NNS
cord-002407-25cawzi0	431	46	of	of	IN
cord-002407-25cawzi0	431	47	single	single	JJ
cord-002407-25cawzi0	431	48	-	-	HYPH
cord-002407-25cawzi0	431	49	cycle	cycle	NN
cord-002407-25cawzi0	431	50	infectious	infectious	JJ
cord-002407-25cawzi0	431	51	influenza	influenza	NN
cord-002407-25cawzi0	431	52	A	a	DT
cord-002407-25cawzi0	431	53	virus	virus	NN
cord-002407-25cawzi0	431	54	(	(	-LRB-
cord-002407-25cawzi0	431	55	sciIAV	sciiav	NN
cord-002407-25cawzi0	431	56	)	)	-RRB-
cord-002407-25cawzi0	431	57	Replication	replication	NN
cord-002407-25cawzi0	431	58	-	-	HYPH
cord-002407-25cawzi0	431	59	competent	competent	JJ
cord-002407-25cawzi0	431	60	influenza	influenza	NN
cord-002407-25cawzi0	431	61	A	a	DT
cord-002407-25cawzi0	431	62	viruses	virus	NNS
cord-002407-25cawzi0	431	63	expressing	express	VBG
cord-002407-25cawzi0	431	64	reporter	reporter	NN
cord-002407-25cawzi0	431	65	genes	gene	NNS
cord-002407-25cawzi0	431	66	Replication	replication	NN
cord-002407-25cawzi0	431	67	-	-	HYPH
cord-002407-25cawzi0	431	68	competent	competent	JJ
cord-002407-25cawzi0	431	69	fluorescent	fluorescent	NN
cord-002407-25cawzi0	431	70	-	-	HYPH
cord-002407-25cawzi0	431	71	expressing	express	VBG
cord-002407-25cawzi0	431	72	influenza	influenza	NN
cord-002407-25cawzi0	431	73	B	b	NN
cord-002407-25cawzi0	431	74	virus	virus	NN
cord-002407-25cawzi0	431	75	Replication	replication	NN
cord-002407-25cawzi0	431	76	-	-	HYPH
cord-002407-25cawzi0	431	77	competent	competent	JJ
cord-002407-25cawzi0	431	78	influenza	influenza	NN
cord-002407-25cawzi0	431	79	A	a	NN
cord-002407-25cawzi0	431	80	and	and	CC
cord-002407-25cawzi0	431	81	B	b	NN
cord-002407-25cawzi0	431	82	viruses	virus	NNS
cord-002407-25cawzi0	431	83	expressing	express	VBG
cord-002407-25cawzi0	431	84	a	a	DT
cord-002407-25cawzi0	431	85	fluorescent	fluorescent	JJ
cord-002407-25cawzi0	431	86	dynamic	dynamic	JJ
cord-002407-25cawzi0	431	87	timer	timer	NN
cord-002407-25cawzi0	431	88	protein	protein	NN
cord-002407-25cawzi0	431	89	for	for	IN
cord-002407-25cawzi0	431	90	in	in	IN
cord-002407-25cawzi0	431	91	vitro	vitro	FW
cord-002407-25cawzi0	431	92	and	and	CC
cord-002407-25cawzi0	431	93	in	in	IN
cord-002407-25cawzi0	431	94	vivo	vivo	NNP
cord-002407-25cawzi0	431	95	studies	study	NNS
cord-002407-25cawzi0	432	1	RNA	RNA	NNP
cord-002407-25cawzi0	432	2	polymerase	polymerase	NNP
cord-002407-25cawzi0	433	1	I	-PRON-	PRP
cord-002407-25cawzi0	433	2	catalysed	catalyse	VBD
cord-002407-25cawzi0	434	1	transcription	transcription	NN
cord-002407-25cawzi0	434	2	of	of	IN
cord-002407-25cawzi0	434	3	insert	insert	JJ
cord-002407-25cawzi0	434	4	viral	viral	JJ
cord-002407-25cawzi0	434	5	cDNA	cdna	NN
cord-002407-25cawzi0	434	6	RNA	rna	NN
cord-002407-25cawzi0	434	7	polymerase	polymerase	NN
cord-002407-25cawzi0	434	8	I	i	NN
cord-002407-25cawzi0	434	9	-	-	HYPH
cord-002407-25cawzi0	434	10	mediated	mediate	VBN
cord-002407-25cawzi0	434	11	expression	expression	NN
cord-002407-25cawzi0	434	12	of	of	IN
cord-002407-25cawzi0	434	13	influenza	influenza	JJ
cord-002407-25cawzi0	434	14	viral	viral	JJ
cord-002407-25cawzi0	434	15	RNA	RNA	NNP
cord-002407-25cawzi0	434	16	molecules	molecule	NNS
cord-002407-25cawzi0	434	17	A	a	DT
cord-002407-25cawzi0	434	18	DNA	dna	NN
cord-002407-25cawzi0	434	19	transfection	transfection	NN
cord-002407-25cawzi0	434	20	system	system	NN
cord-002407-25cawzi0	434	21	for	for	IN
cord-002407-25cawzi0	434	22	generation	generation	NN
cord-002407-25cawzi0	434	23	of	of	IN
cord-002407-25cawzi0	434	24	influenza	influenza	NN
cord-002407-25cawzi0	434	25	A	a	DT
cord-002407-25cawzi0	434	26	virus	virus	NN
cord-002407-25cawzi0	434	27	from	from	IN
cord-002407-25cawzi0	434	28	eight	eight	CD
cord-002407-25cawzi0	434	29	plasmids	plasmid	NNS
cord-002407-25cawzi0	435	1	Ambisense	Ambisense	NNP
cord-002407-25cawzi0	435	2	"	"	``
cord-002407-25cawzi0	435	3	approach	approach	NN
cord-002407-25cawzi0	435	4	for	for	IN
cord-002407-25cawzi0	435	5	the	the	DT
cord-002407-25cawzi0	435	6	generation	generation	NN
cord-002407-25cawzi0	435	7	of	of	IN
cord-002407-25cawzi0	435	8	influenza	influenza	NN
cord-002407-25cawzi0	435	9	A	a	DT
cord-002407-25cawzi0	435	10	virus	virus	NN
cord-002407-25cawzi0	435	11	:	:	:
cord-002407-25cawzi0	435	12	vRNA	vRNA	NNP
cord-002407-25cawzi0	435	13	and	and	CC
cord-002407-25cawzi0	435	14	mRNA	mRNA	NNP
cord-002407-25cawzi0	435	15	synthesis	synthesis	NN
cord-002407-25cawzi0	435	16	from	from	IN
cord-002407-25cawzi0	435	17	one	one	CD
cord-002407-25cawzi0	435	18	template	template	NN
cord-002407-25cawzi0	435	19	Generation	generation	NN
cord-002407-25cawzi0	435	20	of	of	IN
cord-002407-25cawzi0	435	21	recombinant	recombinant	JJ
cord-002407-25cawzi0	435	22	arenavirus	arenavirus	NN
cord-002407-25cawzi0	435	23	for	for	IN
cord-002407-25cawzi0	435	24	vaccine	vaccine	NN
cord-002407-25cawzi0	435	25	development	development	NN
cord-002407-25cawzi0	435	26	in	in	IN
cord-002407-25cawzi0	435	27	fda	fda	NNP
cord-002407-25cawzi0	435	28	-	-	HYPH
cord-002407-25cawzi0	435	29	approved	approve	VBN
cord-002407-25cawzi0	435	30	vero	vero	NNP
cord-002407-25cawzi0	435	31	cells	cell	NNS
cord-002407-25cawzi0	435	32	Arenavirus	Arenavirus	NNP
cord-002407-25cawzi0	435	33	reverse	reverse	JJ
cord-002407-25cawzi0	435	34	genetics	genetic	NNS
cord-002407-25cawzi0	435	35	for	for	IN
cord-002407-25cawzi0	435	36	vaccine	vaccine	NN
cord-002407-25cawzi0	435	37	development	development	NN
cord-002407-25cawzi0	435	38	Generation	Generation	NNP
cord-002407-25cawzi0	435	39	of	of	IN
cord-002407-25cawzi0	435	40	influenza	influenza	NN
cord-002407-25cawzi0	435	41	A	a	DT
cord-002407-25cawzi0	435	42	viruses	virus	NNS
cord-002407-25cawzi0	435	43	entirely	entirely	RB
cord-002407-25cawzi0	435	44	from	from	IN
cord-002407-25cawzi0	435	45	cloned	clone	VBN
cord-002407-25cawzi0	435	46	cDNAs	cDNAs	.
cord-002407-25cawzi0	436	1	Cloning	clone	VBG
cord-002407-25cawzi0	436	2	of	of	IN
cord-002407-25cawzi0	436	3	the	the	DT
cord-002407-25cawzi0	436	4	canine	canine	JJ
cord-002407-25cawzi0	436	5	RNA	RNA	NNP
cord-002407-25cawzi0	436	6	polymerase	polymerase	NN
cord-002407-25cawzi0	436	7	I	-PRON-	PRP
cord-002407-25cawzi0	436	8	promoter	promoter	NN
cord-002407-25cawzi0	436	9	and	and	CC
cord-002407-25cawzi0	436	10	establishment	establishment	NN
cord-002407-25cawzi0	436	11	of	of	IN
cord-002407-25cawzi0	436	12	reverse	reverse	JJ
cord-002407-25cawzi0	436	13	genetics	genetic	NNS
cord-002407-25cawzi0	436	14	for	for	IN
cord-002407-25cawzi0	436	15	influenza	influenza	NN
cord-002407-25cawzi0	436	16	A	a	NN
cord-002407-25cawzi0	436	17	and	and	CC
cord-002407-25cawzi0	436	18	B	b	NN
cord-002407-25cawzi0	436	19	in	in	IN
cord-002407-25cawzi0	436	20	MDCK	MDCK	NNP
cord-002407-25cawzi0	436	21	cells	cell	NNS
cord-002407-25cawzi0	436	22	Cloning	clone	VBG
cord-002407-25cawzi0	436	23	of	of	IN
cord-002407-25cawzi0	436	24	the	the	DT
cord-002407-25cawzi0	436	25	chicken	chicken	NN
cord-002407-25cawzi0	436	26	RNA	RNA	NNP
cord-002407-25cawzi0	436	27	polymerase	polymerase	NN
cord-002407-25cawzi0	436	28	I	-PRON-	PRP
cord-002407-25cawzi0	436	29	promoter	promoter	VBP
cord-002407-25cawzi0	436	30	and	and	CC
cord-002407-25cawzi0	436	31	use	use	NN
cord-002407-25cawzi0	436	32	for	for	IN
cord-002407-25cawzi0	436	33	reverse	reverse	JJ
cord-002407-25cawzi0	436	34	genetics	genetic	NNS
cord-002407-25cawzi0	436	35	of	of	IN
cord-002407-25cawzi0	436	36	influenza	influenza	NN
cord-002407-25cawzi0	436	37	A	a	DT
cord-002407-25cawzi0	436	38	viruses	virus	NNS
cord-002407-25cawzi0	436	39	in	in	IN
cord-002407-25cawzi0	436	40	avian	avian	JJ
cord-002407-25cawzi0	436	41	cells	cell	NNS
cord-002407-25cawzi0	437	1	Efficient	efficient	JJ
cord-002407-25cawzi0	437	2	generation	generation	NN
cord-002407-25cawzi0	437	3	of	of	IN
cord-002407-25cawzi0	437	4	influenza	influenza	NN
cord-002407-25cawzi0	437	5	virus	virus	NN
cord-002407-25cawzi0	437	6	with	with	IN
cord-002407-25cawzi0	437	7	a	a	DT
cord-002407-25cawzi0	437	8	mouse	mouse	NN
cord-002407-25cawzi0	437	9	RNA	RNA	NNP
cord-002407-25cawzi0	437	10	polymerase	polymerase	NN
cord-002407-25cawzi0	437	11	I	i	NN
cord-002407-25cawzi0	437	12	-	-	HYPH
cord-002407-25cawzi0	437	13	driven	drive	VBN
cord-002407-25cawzi0	437	14	all	all	DT
cord-002407-25cawzi0	437	15	-	-	HYPH
cord-002407-25cawzi0	437	16	in	in	IN
cord-002407-25cawzi0	437	17	-	-	HYPH
cord-002407-25cawzi0	437	18	one	one	CD
cord-002407-25cawzi0	437	19	plasmid	plasmid	NN
cord-002407-25cawzi0	437	20	Cloning	clone	VBG
cord-002407-25cawzi0	437	21	the	the	DT
cord-002407-25cawzi0	437	22	horse	horse	NN
cord-002407-25cawzi0	437	23	RNA	RNA	NNP
cord-002407-25cawzi0	437	24	polymerase	polymerase	NN
cord-002407-25cawzi0	437	25	I	-PRON-	PRP
cord-002407-25cawzi0	437	26	promoter	promoter	NN
cord-002407-25cawzi0	437	27	and	and	CC
cord-002407-25cawzi0	437	28	its	-PRON-	PRP$
cord-002407-25cawzi0	437	29	application	application	NN
cord-002407-25cawzi0	437	30	to	to	IN
cord-002407-25cawzi0	437	31	studying	study	VBG
cord-002407-25cawzi0	437	32	influenza	influenza	NN
cord-002407-25cawzi0	437	33	virus	virus	NN
cord-002407-25cawzi0	437	34	polymerase	polymerase	NN
cord-002407-25cawzi0	437	35	activity	activity	NN
cord-002407-25cawzi0	437	36	Rescue	Rescue	NNP
cord-002407-25cawzi0	437	37	of	of	IN
cord-002407-25cawzi0	437	38	influenza	influenza	NN
cord-002407-25cawzi0	437	39	A	a	DT
cord-002407-25cawzi0	437	40	virus	virus	NN
cord-002407-25cawzi0	437	41	from	from	IN
cord-002407-25cawzi0	438	1	recombinant	recombinant	JJ
cord-002407-25cawzi0	438	2	DNA	DNA	NNP
cord-002407-25cawzi0	438	3	Universal	Universal	NNP
cord-002407-25cawzi0	438	4	influenza	influenza	NN
cord-002407-25cawzi0	438	5	B	b	NN
cord-002407-25cawzi0	438	6	virus	virus	NN
cord-002407-25cawzi0	438	7	genomic	genomic	JJ
cord-002407-25cawzi0	438	8	amplification	amplification	NN
cord-002407-25cawzi0	438	9	facilitates	facilitate	VBZ
cord-002407-25cawzi0	438	10	sequencing	sequencing	NN
cord-002407-25cawzi0	438	11	,	,	,
cord-002407-25cawzi0	438	12	diagnostics	diagnostic	NNS
cord-002407-25cawzi0	438	13	,	,	,
cord-002407-25cawzi0	438	14	and	and	CC
cord-002407-25cawzi0	438	15	reverse	reverse	VB
cord-002407-25cawzi0	438	16	genetics	genetic	NNS
cord-002407-25cawzi0	439	1	A	a	DT
cord-002407-25cawzi0	439	2	reverse	reverse	JJ
cord-002407-25cawzi0	439	3	genetics	genetics	NN
cord-002407-25cawzi0	439	4	approach	approach	NN
cord-002407-25cawzi0	439	5	for	for	IN
cord-002407-25cawzi0	439	6	recovery	recovery	NN
cord-002407-25cawzi0	439	7	of	of	IN
cord-002407-25cawzi0	439	8	recombinant	recombinant	JJ
cord-002407-25cawzi0	439	9	influenza	influenza	NN
cord-002407-25cawzi0	439	10	B	b	NN
cord-002407-25cawzi0	439	11	viruses	virus	NNS
cord-002407-25cawzi0	439	12	entirely	entirely	RB
cord-002407-25cawzi0	439	13	from	from	IN
cord-002407-25cawzi0	439	14	cDNA	cDNA	NNP
cord-002407-25cawzi0	439	15	Rescue	Rescue	NNP
cord-002407-25cawzi0	439	16	of	of	IN
cord-002407-25cawzi0	439	17	influenza	influenza	NN
cord-002407-25cawzi0	439	18	B	b	NN
cord-002407-25cawzi0	439	19	virus	virus	NN
cord-002407-25cawzi0	439	20	from	from	IN
cord-002407-25cawzi0	439	21	eight	eight	CD
cord-002407-25cawzi0	439	22	plasmids	plasmid	NNS
cord-002407-25cawzi0	439	23	Taming	Taming	NNP
cord-002407-25cawzi0	439	24	influenza	influenza	NN
cord-002407-25cawzi0	439	25	viruses	virus	NNS
cord-002407-25cawzi0	440	1	Specific	specific	JJ
cord-002407-25cawzi0	440	2	residues	residue	NNS
cord-002407-25cawzi0	440	3	of	of	IN
cord-002407-25cawzi0	440	4	the	the	DT
cord-002407-25cawzi0	440	5	influenza	influenza	NN
cord-002407-25cawzi0	440	6	A	a	DT
cord-002407-25cawzi0	440	7	virus	virus	NN
cord-002407-25cawzi0	440	8	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	440	9	viral	viral	JJ
cord-002407-25cawzi0	440	10	RNA	RNA	NNP
cord-002407-25cawzi0	440	11	are	be	VBP
cord-002407-25cawzi0	440	12	important	important	JJ
cord-002407-25cawzi0	440	13	for	for	IN
cord-002407-25cawzi0	440	14	efficient	efficient	JJ
cord-002407-25cawzi0	440	15	packaging	packaging	NN
cord-002407-25cawzi0	440	16	into	into	IN
cord-002407-25cawzi0	440	17	budding	bud	VBG
cord-002407-25cawzi0	440	18	virions	virion	NNS
cord-002407-25cawzi0	441	1	Experimental	experimental	JJ
cord-002407-25cawzi0	441	2	approaches	approach	NNS
cord-002407-25cawzi0	441	3	to	to	TO
cord-002407-25cawzi0	441	4	study	study	VB
cord-002407-25cawzi0	441	5	genome	genome	NN
cord-002407-25cawzi0	441	6	packaging	packaging	NN
cord-002407-25cawzi0	441	7	of	of	IN
cord-002407-25cawzi0	441	8	influenza	influenza	NN
cord-002407-25cawzi0	441	9	A	a	NN
cord-002407-25cawzi0	441	10	viruses	virus	NNS
cord-002407-25cawzi0	441	11	Plasmid	Plasmid	NNP
cord-002407-25cawzi0	441	12	-	-	HYPH
cord-002407-25cawzi0	441	13	only	only	JJ
cord-002407-25cawzi0	441	14	rescue	rescue	NN
cord-002407-25cawzi0	441	15	of	of	IN
cord-002407-25cawzi0	441	16	influenza	influenza	NN
cord-002407-25cawzi0	441	17	A	a	DT
cord-002407-25cawzi0	441	18	virus	virus	NN
cord-002407-25cawzi0	441	19	vaccine	vaccine	NN
cord-002407-25cawzi0	441	20	candidates	candidate	NNS
cord-002407-25cawzi0	442	1	Live	live	VB
cord-002407-25cawzi0	442	2	attenuated	attenuated	JJ
cord-002407-25cawzi0	442	3	influenza	influenza	NN
cord-002407-25cawzi0	442	4	viruses	virus	NNS
cord-002407-25cawzi0	442	5	containing	contain	VBG
cord-002407-25cawzi0	442	6	NS1	ns1	NN
cord-002407-25cawzi0	442	7	truncations	truncation	NNS
cord-002407-25cawzi0	442	8	as	as	IN
cord-002407-25cawzi0	442	9	vaccine	vaccine	NN
cord-002407-25cawzi0	442	10	candidates	candidate	NNS
cord-002407-25cawzi0	442	11	against	against	IN
cord-002407-25cawzi0	442	12	H5N1	H5N1	NNP
cord-002407-25cawzi0	442	13	highly	highly	RB
cord-002407-25cawzi0	442	14	pathogenic	pathogenic	JJ
cord-002407-25cawzi0	442	15	avian	avian	JJ
cord-002407-25cawzi0	442	16	influenza	influenza	NN
cord-002407-25cawzi0	443	1	Attenuated	attenuated	JJ
cord-002407-25cawzi0	443	2	influenza	influenza	NN
cord-002407-25cawzi0	443	3	virus	virus	NN
cord-002407-25cawzi0	443	4	vaccines	vaccine	NNS
cord-002407-25cawzi0	443	5	with	with	IN
cord-002407-25cawzi0	443	6	modified	modify	VBN
cord-002407-25cawzi0	443	7	NS1	NS1	NNS
cord-002407-25cawzi0	443	8	proteins	protein	NNS
cord-002407-25cawzi0	443	9	Efficacy	Efficacy	NNP
cord-002407-25cawzi0	443	10	of	of	IN
cord-002407-25cawzi0	443	11	intranasal	intranasal	NNP
cord-002407-25cawzi0	443	12	administration	administration	NN
cord-002407-25cawzi0	443	13	of	of	IN
cord-002407-25cawzi0	443	14	a	a	DT
cord-002407-25cawzi0	443	15	truncated	truncated	JJ
cord-002407-25cawzi0	443	16	NS1	ns1	NN
cord-002407-25cawzi0	443	17	modified	modify	VBN
cord-002407-25cawzi0	443	18	live	live	JJ
cord-002407-25cawzi0	443	19	influenza	influenza	NN
cord-002407-25cawzi0	443	20	virus	virus	NN
cord-002407-25cawzi0	443	21	vaccine	vaccine	NN
cord-002407-25cawzi0	443	22	in	in	IN
cord-002407-25cawzi0	443	23	swine	swine	NN
cord-002407-25cawzi0	443	24	Attenuation	attenuation	NN
cord-002407-25cawzi0	443	25	of	of	IN
cord-002407-25cawzi0	443	26	equine	equine	JJ
cord-002407-25cawzi0	443	27	influenza	influenza	NN
cord-002407-25cawzi0	443	28	viruses	viruse	VBZ
cord-002407-25cawzi0	443	29	through	through	IN
cord-002407-25cawzi0	443	30	truncations	truncation	NNS
cord-002407-25cawzi0	443	31	of	of	IN
cord-002407-25cawzi0	443	32	the	the	DT
cord-002407-25cawzi0	443	33	NS1	ns1	NN
cord-002407-25cawzi0	443	34	protein	protein	NN
cord-002407-25cawzi0	443	35	Attenuation	attenuation	NN
cord-002407-25cawzi0	443	36	and	and	CC
cord-002407-25cawzi0	443	37	immunogenicity	immunogenicity	NN
cord-002407-25cawzi0	443	38	in	in	IN
cord-002407-25cawzi0	443	39	mice	mouse	NNS
cord-002407-25cawzi0	443	40	of	of	IN
cord-002407-25cawzi0	443	41	temperature	temperature	NN
cord-002407-25cawzi0	443	42	-	-	HYPH
cord-002407-25cawzi0	443	43	sensitive	sensitive	JJ
cord-002407-25cawzi0	443	44	influenza	influenza	NN
cord-002407-25cawzi0	443	45	viruses	virus	NNS
cord-002407-25cawzi0	443	46	expressing	express	VBG
cord-002407-25cawzi0	443	47	truncated	truncate	VBN
cord-002407-25cawzi0	443	48	NS1	NS1	NNS
cord-002407-25cawzi0	443	49	proteins	protein	NNS
cord-002407-25cawzi0	443	50	Immunogenicity	Immunogenicity	NNP
cord-002407-25cawzi0	443	51	and	and	CC
cord-002407-25cawzi0	443	52	protection	protection	NN
cord-002407-25cawzi0	443	53	efficacy	efficacy	NN
cord-002407-25cawzi0	443	54	of	of	IN
cord-002407-25cawzi0	443	55	replication	replication	NN
cord-002407-25cawzi0	443	56	-	-	HYPH
cord-002407-25cawzi0	443	57	deficient	deficient	JJ
cord-002407-25cawzi0	443	58	influenza	influenza	NN
cord-002407-25cawzi0	443	59	A	a	DT
cord-002407-25cawzi0	443	60	viruses	virus	NNS
cord-002407-25cawzi0	443	61	with	with	IN
cord-002407-25cawzi0	443	62	altered	alter	VBN
cord-002407-25cawzi0	443	63	NS1	ns1	NN
cord-002407-25cawzi0	443	64	genes	gene	NNS
cord-002407-25cawzi0	443	65	Vaccination	vaccination	NN
cord-002407-25cawzi0	443	66	of	of	IN
cord-002407-25cawzi0	443	67	pigs	pig	NNS
cord-002407-25cawzi0	443	68	against	against	IN
cord-002407-25cawzi0	443	69	swine	swine	NN
cord-002407-25cawzi0	443	70	influenza	influenza	NN
cord-002407-25cawzi0	443	71	viruses	virus	NNS
cord-002407-25cawzi0	443	72	by	by	IN
cord-002407-25cawzi0	443	73	using	use	VBG
cord-002407-25cawzi0	443	74	an	an	DT
cord-002407-25cawzi0	443	75	NS1-truncated	ns1-truncate	VBN
cord-002407-25cawzi0	443	76	modified	modify	VBN
cord-002407-25cawzi0	443	77	live	live	NN
cord-002407-25cawzi0	443	78	-	-	HYPH
cord-002407-25cawzi0	443	79	virus	virus	NN
cord-002407-25cawzi0	443	80	vaccine	vaccine	NN
cord-002407-25cawzi0	443	81	Mutations	Mutations	NNPS
cord-002407-25cawzi0	443	82	in	in	IN
cord-002407-25cawzi0	443	83	the	the	DT
cord-002407-25cawzi0	443	84	NS1	ns1	NN
cord-002407-25cawzi0	443	85	protein	protein	NN
cord-002407-25cawzi0	443	86	of	of	IN
cord-002407-25cawzi0	443	87	swine	swine	NNP
cord-002407-25cawzi0	443	88	influenza	influenza	NNP
cord-002407-25cawzi0	443	89	virus	virus	NN
cord-002407-25cawzi0	443	90	impair	impair	VBP
cord-002407-25cawzi0	443	91	anti	anti	JJ
cord-002407-25cawzi0	443	92	-	-	JJ
cord-002407-25cawzi0	443	93	interferon	interferon	JJ
cord-002407-25cawzi0	443	94	activity	activity	NN
cord-002407-25cawzi0	443	95	and	and	CC
cord-002407-25cawzi0	443	96	confer	confer	VB
cord-002407-25cawzi0	443	97	attenuation	attenuation	NN
cord-002407-25cawzi0	443	98	in	in	IN
cord-002407-25cawzi0	443	99	pigs	pig	NNS
cord-002407-25cawzi0	443	100	Characterization	characterization	NN
cord-002407-25cawzi0	443	101	of	of	IN
cord-002407-25cawzi0	443	102	influenza	influenza	NN
cord-002407-25cawzi0	443	103	virus	virus	NN
cord-002407-25cawzi0	443	104	variants	variant	NNS
cord-002407-25cawzi0	443	105	with	with	IN
cord-002407-25cawzi0	443	106	different	different	JJ
cord-002407-25cawzi0	443	107	sizes	size	NNS
cord-002407-25cawzi0	443	108	of	of	IN
cord-002407-25cawzi0	443	109	the	the	DT
cord-002407-25cawzi0	443	110	non	non	JJ
cord-002407-25cawzi0	443	111	-	-	JJ
cord-002407-25cawzi0	443	112	structural	structural	JJ
cord-002407-25cawzi0	443	113	(	(	-LRB-
cord-002407-25cawzi0	443	114	NS	NS	NNP
cord-002407-25cawzi0	443	115	)	)	-RRB-
cord-002407-25cawzi0	443	116	genes	gene	NNS
cord-002407-25cawzi0	443	117	and	and	CC
cord-002407-25cawzi0	443	118	their	-PRON-	PRP$
cord-002407-25cawzi0	443	119	potential	potential	NN
cord-002407-25cawzi0	443	120	as	as	IN
cord-002407-25cawzi0	443	121	a	a	DT
cord-002407-25cawzi0	443	122	live	live	JJ
cord-002407-25cawzi0	443	123	influenza	influenza	NN
cord-002407-25cawzi0	443	124	vaccine	vaccine	NN
cord-002407-25cawzi0	443	125	in	in	IN
cord-002407-25cawzi0	443	126	poultry	poultry	NN
cord-002407-25cawzi0	443	127	Development	Development	NNP
cord-002407-25cawzi0	443	128	of	of	IN
cord-002407-25cawzi0	443	129	a	a	DT
cord-002407-25cawzi0	443	130	dual	dual	JJ
cord-002407-25cawzi0	443	131	-	-	HYPH
cord-002407-25cawzi0	443	132	protective	protective	JJ
cord-002407-25cawzi0	443	133	live	live	NN
cord-002407-25cawzi0	443	134	-	-	HYPH
cord-002407-25cawzi0	443	135	attenuated	attenuated	JJ
cord-002407-25cawzi0	443	136	vaccine	vaccine	NN
cord-002407-25cawzi0	443	137	against	against	IN
cord-002407-25cawzi0	443	138	H5N1	H5N1	NNP
cord-002407-25cawzi0	443	139	and	and	CC
cord-002407-25cawzi0	443	140	H9N2	H9N2	NNP
cord-002407-25cawzi0	443	141	avian	avian	JJ
cord-002407-25cawzi0	443	142	influenza	influenza	NN
cord-002407-25cawzi0	443	143	viruses	virus	NNS
cord-002407-25cawzi0	443	144	by	by	IN
cord-002407-25cawzi0	443	145	modifying	modify	VBG
cord-002407-25cawzi0	443	146	the	the	DT
cord-002407-25cawzi0	443	147	NS1	ns1	NN
cord-002407-25cawzi0	443	148	gene	gene	NN
cord-002407-25cawzi0	443	149	Canine	canine	JJ
cord-002407-25cawzi0	443	150	influenza	influenza	NN
cord-002407-25cawzi0	443	151	viruses	virus	NNS
cord-002407-25cawzi0	443	152	with	with	IN
cord-002407-25cawzi0	443	153	modified	modify	VBN
cord-002407-25cawzi0	443	154	NS1	ns1	NN
cord-002407-25cawzi0	443	155	proteins	protein	NNS
cord-002407-25cawzi0	443	156	for	for	IN
cord-002407-25cawzi0	443	157	the	the	DT
cord-002407-25cawzi0	443	158	development	development	NN
cord-002407-25cawzi0	443	159	of	of	IN
cord-002407-25cawzi0	443	160	live	live	RB
cord-002407-25cawzi0	443	161	-	-	HYPH
cord-002407-25cawzi0	443	162	attenuated	attenuate	VBN
cord-002407-25cawzi0	443	163	vaccines	vaccine	NNS
cord-002407-25cawzi0	443	164	Functional	functional	JJ
cord-002407-25cawzi0	443	165	genomic	genomic	JJ
cord-002407-25cawzi0	443	166	and	and	CC
cord-002407-25cawzi0	443	167	serological	serological	JJ
cord-002407-25cawzi0	443	168	analysis	analysis	NN
cord-002407-25cawzi0	443	169	of	of	IN
cord-002407-25cawzi0	443	170	the	the	DT
cord-002407-25cawzi0	443	171	protective	protective	JJ
cord-002407-25cawzi0	443	172	immune	immune	JJ
cord-002407-25cawzi0	443	173	response	response	NN
cord-002407-25cawzi0	443	174	resulting	result	VBG
cord-002407-25cawzi0	443	175	from	from	IN
cord-002407-25cawzi0	443	176	vaccination	vaccination	NN
cord-002407-25cawzi0	443	177	of	of	IN
cord-002407-25cawzi0	443	178	macaques	macaque	NNS
cord-002407-25cawzi0	443	179	with	with	IN
cord-002407-25cawzi0	443	180	an	an	DT
cord-002407-25cawzi0	443	181	NS1-truncated	ns1-truncate	VBN
cord-002407-25cawzi0	443	182	influenza	influenza	NN
cord-002407-25cawzi0	443	183	virus	virus	NN
cord-002407-25cawzi0	443	184	NS1-truncated	ns1-truncate	VBN
cord-002407-25cawzi0	444	1	live	live	RB
cord-002407-25cawzi0	444	2	-	-	HYPH
cord-002407-25cawzi0	444	3	attenuated	attenuate	VBN
cord-002407-25cawzi0	444	4	virus	virus	NN
cord-002407-25cawzi0	444	5	vaccine	vaccine	NN
cord-002407-25cawzi0	444	6	provides	provide	VBZ
cord-002407-25cawzi0	444	7	robust	robust	JJ
cord-002407-25cawzi0	444	8	protection	protection	NN
cord-002407-25cawzi0	444	9	to	to	IN
cord-002407-25cawzi0	444	10	aged	aged	JJ
cord-002407-25cawzi0	444	11	mice	mouse	NNS
cord-002407-25cawzi0	444	12	from	from	IN
cord-002407-25cawzi0	444	13	viral	viral	JJ
cord-002407-25cawzi0	444	14	challenge	challenge	NN
cord-002407-25cawzi0	444	15	Influenza	Influenza	NNP
cord-002407-25cawzi0	444	16	B	B	NNP
cord-002407-25cawzi0	444	17	virus	virus	NN
cord-002407-25cawzi0	444	18	NS1-truncated	ns1-truncate	VBN
cord-002407-25cawzi0	444	19	mutants	mutant	NNS
cord-002407-25cawzi0	444	20	:	:	:
cord-002407-25cawzi0	444	21	Live	live	RB
cord-002407-25cawzi0	444	22	-	-	HYPH
cord-002407-25cawzi0	444	23	attenuated	attenuated	JJ
cord-002407-25cawzi0	444	24	vaccine	vaccine	NN
cord-002407-25cawzi0	444	25	approach	approach	NN
cord-002407-25cawzi0	444	26	Influenza	Influenza	NNP
cord-002407-25cawzi0	444	27	A	A	NNP
cord-002407-25cawzi0	444	28	and	and	CC
cord-002407-25cawzi0	444	29	B	b	NN
cord-002407-25cawzi0	444	30	viruses	virus	NNS
cord-002407-25cawzi0	444	31	expressing	express	VBG
cord-002407-25cawzi0	444	32	altered	alter	VBN
cord-002407-25cawzi0	444	33	NS1	ns1	NN
cord-002407-25cawzi0	444	34	proteins	protein	NNS
cord-002407-25cawzi0	444	35	:	:	:
cord-002407-25cawzi0	444	36	A	a	DT
cord-002407-25cawzi0	444	37	vaccine	vaccine	NN
cord-002407-25cawzi0	444	38	approach	approach	NN
cord-002407-25cawzi0	444	39	Development	Development	NNP
cord-002407-25cawzi0	444	40	of	of	IN
cord-002407-25cawzi0	444	41	live	live	RB
cord-002407-25cawzi0	444	42	-	-	HYPH
cord-002407-25cawzi0	444	43	attenuated	attenuate	VBN
cord-002407-25cawzi0	444	44	arenavirus	arenavirus	NNP
cord-002407-25cawzi0	444	45	vaccines	vaccine	NNS
cord-002407-25cawzi0	444	46	based	base	VBN
cord-002407-25cawzi0	444	47	on	on	IN
cord-002407-25cawzi0	444	48	codon	codon	NN
cord-002407-25cawzi0	444	49	deoptimization	deoptimization	NN
cord-002407-25cawzi0	445	1	Live	live	VB
cord-002407-25cawzi0	446	1	attenuated	attenuated	JJ
cord-002407-25cawzi0	446	2	influenza	influenza	NN
cord-002407-25cawzi0	446	3	virus	virus	NN
cord-002407-25cawzi0	446	4	vaccines	vaccine	NNS
cord-002407-25cawzi0	446	5	by	by	IN
cord-002407-25cawzi0	446	6	computer	computer	NN
cord-002407-25cawzi0	446	7	-	-	HYPH
cord-002407-25cawzi0	446	8	aided	aid	VBN
cord-002407-25cawzi0	446	9	rational	rational	JJ
cord-002407-25cawzi0	446	10	design	design	NN
cord-002407-25cawzi0	446	11	Deliberate	deliberate	JJ
cord-002407-25cawzi0	446	12	reduction	reduction	NN
cord-002407-25cawzi0	446	13	of	of	IN
cord-002407-25cawzi0	446	14	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	446	15	and	and	CC
cord-002407-25cawzi0	446	16	neuraminidase	neuraminidase	JJ
cord-002407-25cawzi0	446	17	expression	expression	NN
cord-002407-25cawzi0	446	18	of	of	IN
cord-002407-25cawzi0	446	19	influenza	influenza	NN
cord-002407-25cawzi0	446	20	virus	virus	NN
cord-002407-25cawzi0	446	21	leads	lead	VBZ
cord-002407-25cawzi0	446	22	to	to	IN
cord-002407-25cawzi0	446	23	an	an	DT
cord-002407-25cawzi0	446	24	ultraprotective	ultraprotective	JJ
cord-002407-25cawzi0	446	25	live	live	JJ
cord-002407-25cawzi0	446	26	vaccine	vaccine	NN
cord-002407-25cawzi0	446	27	in	in	IN
cord-002407-25cawzi0	446	28	mice	mouse	NNS
cord-002407-25cawzi0	447	1	A	a	DT
cord-002407-25cawzi0	447	2	replication	replication	NN
cord-002407-25cawzi0	447	3	-	-	HYPH
cord-002407-25cawzi0	447	4	incompetent	incompetent	JJ
cord-002407-25cawzi0	447	5	virus	virus	NN
cord-002407-25cawzi0	447	6	possessing	possess	VBG
cord-002407-25cawzi0	447	7	an	an	DT
cord-002407-25cawzi0	447	8	uncleavable	uncleavable	JJ
cord-002407-25cawzi0	447	9	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	447	10	as	as	IN
cord-002407-25cawzi0	447	11	an	an	DT
cord-002407-25cawzi0	447	12	influenza	influenza	NN
cord-002407-25cawzi0	447	13	vaccine	vaccine	NN
cord-002407-25cawzi0	447	14	Pseudotyped	Pseudotyped	NNP
cord-002407-25cawzi0	447	15	influenza	influenza	NN
cord-002407-25cawzi0	447	16	A	a	DT
cord-002407-25cawzi0	447	17	virus	virus	NN
cord-002407-25cawzi0	447	18	as	as	IN
cord-002407-25cawzi0	447	19	a	a	DT
cord-002407-25cawzi0	447	20	vaccine	vaccine	NN
cord-002407-25cawzi0	447	21	for	for	IN
cord-002407-25cawzi0	447	22	the	the	DT
cord-002407-25cawzi0	447	23	induction	induction	NN
cord-002407-25cawzi0	447	24	of	of	IN
cord-002407-25cawzi0	447	25	heterotypic	heterotypic	NNP
cord-002407-25cawzi0	447	26	immunity	immunity	NN
cord-002407-25cawzi0	447	27	Characterization	characterization	NN
cord-002407-25cawzi0	447	28	of	of	IN
cord-002407-25cawzi0	447	29	a	a	DT
cord-002407-25cawzi0	447	30	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	447	31	-	-	HYPH
cord-002407-25cawzi0	447	32	deficient	deficient	JJ
cord-002407-25cawzi0	447	33	influenza	influenza	NN
cord-002407-25cawzi0	447	34	A	a	DT
cord-002407-25cawzi0	447	35	virus	virus	NN
cord-002407-25cawzi0	447	36	as	as	IN
cord-002407-25cawzi0	447	37	a	a	DT
cord-002407-25cawzi0	447	38	potential	potential	JJ
cord-002407-25cawzi0	447	39	gene	gene	NN
cord-002407-25cawzi0	447	40	delivery	delivery	NN
cord-002407-25cawzi0	447	41	vector	vector	NN
cord-002407-25cawzi0	447	42	and	and	CC
cord-002407-25cawzi0	447	43	a	a	DT
cord-002407-25cawzi0	447	44	live	live	JJ
cord-002407-25cawzi0	447	45	vaccine	vaccine	NN
cord-002407-25cawzi0	447	46	A	a	DT
cord-002407-25cawzi0	447	47	novel	novel	JJ
cord-002407-25cawzi0	447	48	bivalent	bivalent	JJ
cord-002407-25cawzi0	447	49	vaccine	vaccine	NN
cord-002407-25cawzi0	447	50	based	base	VBN
cord-002407-25cawzi0	447	51	on	on	IN
cord-002407-25cawzi0	447	52	a	a	DT
cord-002407-25cawzi0	447	53	PB2-knockout	pb2-knockout	NN
cord-002407-25cawzi0	447	54	influenza	influenza	NN
cord-002407-25cawzi0	447	55	virus	virus	NN
cord-002407-25cawzi0	447	56	protects	protect	VBZ
cord-002407-25cawzi0	447	57	mice	mouse	NNS
cord-002407-25cawzi0	447	58	from	from	IN
cord-002407-25cawzi0	447	59	pandemic	pandemic	JJ
cord-002407-25cawzi0	447	60	H1N1	H1N1	NNP
cord-002407-25cawzi0	447	61	and	and	CC
cord-002407-25cawzi0	447	62	highly	highly	RB
cord-002407-25cawzi0	447	63	pathogenic	pathogenic	JJ
cord-002407-25cawzi0	447	64	H5N1	H5N1	NNP
cord-002407-25cawzi0	447	65	virus	virus	NN
cord-002407-25cawzi0	447	66	challenges	challenge	VBZ
cord-002407-25cawzi0	447	67	A	a	DT
cord-002407-25cawzi0	447	68	replication	replication	NN
cord-002407-25cawzi0	447	69	-	-	HYPH
cord-002407-25cawzi0	447	70	incompetent	incompetent	JJ
cord-002407-25cawzi0	447	71	PB2-knockout	PB2-knockout	NNP
cord-002407-25cawzi0	447	72	influenza	influenza	NN
cord-002407-25cawzi0	447	73	A	a	DT
cord-002407-25cawzi0	447	74	virus	virus	NN
cord-002407-25cawzi0	447	75	vaccine	vaccine	NN
cord-002407-25cawzi0	447	76	vector	vector	NN
cord-002407-25cawzi0	447	77	Induction	Induction	NNP
cord-002407-25cawzi0	447	78	of	of	IN
cord-002407-25cawzi0	447	79	CD8	CD8	NNP
cord-002407-25cawzi0	447	80	T	T	NNP
cord-002407-25cawzi0	447	81	cell	cell	NN
cord-002407-25cawzi0	447	82	heterologous	heterologous	NNP
cord-002407-25cawzi0	447	83	protection	protection	NN
cord-002407-25cawzi0	447	84	by	by	IN
cord-002407-25cawzi0	447	85	a	a	DT
cord-002407-25cawzi0	447	86	single	single	JJ
cord-002407-25cawzi0	447	87	dose	dose	NN
cord-002407-25cawzi0	447	88	of	of	IN
cord-002407-25cawzi0	447	89	single	single	JJ
cord-002407-25cawzi0	447	90	-	-	HYPH
cord-002407-25cawzi0	447	91	cycle	cycle	NN
cord-002407-25cawzi0	447	92	infectious	infectious	JJ
cord-002407-25cawzi0	447	93	influenza	influenza	NN
cord-002407-25cawzi0	447	94	virus	virus	NN
cord-002407-25cawzi0	448	1	An	an	DT
cord-002407-25cawzi0	448	2	eight	eight	CD
cord-002407-25cawzi0	448	3	-	-	HYPH
cord-002407-25cawzi0	448	4	segment	segment	NN
cord-002407-25cawzi0	448	5	swine	swine	NN
cord-002407-25cawzi0	448	6	influenza	influenza	NN
cord-002407-25cawzi0	448	7	virus	virus	NN
cord-002407-25cawzi0	448	8	harboring	harbor	VBG
cord-002407-25cawzi0	448	9	H1	H1	NNP
cord-002407-25cawzi0	448	10	and	and	CC
cord-002407-25cawzi0	448	11	H3	H3	NNP
cord-002407-25cawzi0	448	12	hemagglutinins	hemagglutinins	NNP
cord-002407-25cawzi0	448	13	is	be	VBZ
cord-002407-25cawzi0	448	14	attenuated	attenuated	JJ
cord-002407-25cawzi0	448	15	and	and	CC
cord-002407-25cawzi0	448	16	protective	protective	JJ
cord-002407-25cawzi0	448	17	against	against	IN
cord-002407-25cawzi0	448	18	H1N1	H1N1	NNP
cord-002407-25cawzi0	448	19	and	and	CC
cord-002407-25cawzi0	448	20	H3N2	H3N2	NNP
cord-002407-25cawzi0	448	21	subtypes	subtype	NNS
cord-002407-25cawzi0	448	22	in	in	IN
cord-002407-25cawzi0	448	23	pigs	pig	NNS
cord-002407-25cawzi0	449	1	A	a	DT
cord-002407-25cawzi0	449	2	recombinant	recombinant	JJ
cord-002407-25cawzi0	449	3	influenza	influenza	NN
cord-002407-25cawzi0	449	4	virus	virus	NN
cord-002407-25cawzi0	449	5	vaccine	vaccine	NN
cord-002407-25cawzi0	449	6	expressing	express	VBG
cord-002407-25cawzi0	449	7	the	the	DT
cord-002407-25cawzi0	449	8	f	f	NNP
cord-002407-25cawzi0	449	9	protein	protein	NN
cord-002407-25cawzi0	449	10	of	of	IN
cord-002407-25cawzi0	449	11	respiratory	respiratory	JJ
cord-002407-25cawzi0	449	12	syncytial	syncytial	JJ
cord-002407-25cawzi0	449	13	virus	virus	NN
cord-002407-25cawzi0	449	14	A	a	DT
cord-002407-25cawzi0	449	15	replication	replication	NN
cord-002407-25cawzi0	449	16	-	-	HYPH
cord-002407-25cawzi0	449	17	incompetent	incompetent	JJ
cord-002407-25cawzi0	449	18	influenza	influenza	NN
cord-002407-25cawzi0	449	19	virus	virus	NN
cord-002407-25cawzi0	449	20	bearing	bear	VBG
cord-002407-25cawzi0	449	21	the	the	DT
cord-002407-25cawzi0	449	22	hn	hn	NNP
cord-002407-25cawzi0	449	23	glycoprotein	glycoprotein	NN
cord-002407-25cawzi0	449	24	of	of	IN
cord-002407-25cawzi0	449	25	human	human	JJ
cord-002407-25cawzi0	449	26	parainfluenza	parainfluenza	NNP
cord-002407-25cawzi0	449	27	virus	virus	NNP
cord-002407-25cawzi0	449	28	as	as	IN
cord-002407-25cawzi0	449	29	a	a	DT
cord-002407-25cawzi0	449	30	bivalent	bivalent	JJ
cord-002407-25cawzi0	449	31	vaccine	vaccine	NN
cord-002407-25cawzi0	449	32	A	a	DT
cord-002407-25cawzi0	449	33	bivalent	bivalent	JJ
cord-002407-25cawzi0	449	34	vaccine	vaccine	NN
cord-002407-25cawzi0	449	35	based	base	VBN
cord-002407-25cawzi0	449	36	on	on	IN
cord-002407-25cawzi0	449	37	a	a	DT
cord-002407-25cawzi0	449	38	replication	replication	NN
cord-002407-25cawzi0	449	39	-	-	HYPH
cord-002407-25cawzi0	449	40	incompetent	incompetent	JJ
cord-002407-25cawzi0	449	41	influenza	influenza	NN
cord-002407-25cawzi0	449	42	virus	virus	NN
cord-002407-25cawzi0	449	43	protects	protect	VBZ
cord-002407-25cawzi0	449	44	against	against	IN
cord-002407-25cawzi0	449	45	streptococcus	streptococcus	NN
cord-002407-25cawzi0	449	46	pneumoniae	pneumoniae	NN
cord-002407-25cawzi0	449	47	and	and	CC
cord-002407-25cawzi0	449	48	influenza	influenza	NN
cord-002407-25cawzi0	449	49	virus	virus	NN
cord-002407-25cawzi0	449	50	infection	infection	NN
cord-002407-25cawzi0	449	51	Influenza	influenza	NN
cord-002407-25cawzi0	449	52	viruses	virus	NNS
cord-002407-25cawzi0	449	53	with	with	IN
cord-002407-25cawzi0	449	54	rearranged	rearrange	VBN
cord-002407-25cawzi0	449	55	genomes	genome	NNS
cord-002407-25cawzi0	449	56	as	as	IN
cord-002407-25cawzi0	449	57	live	live	RB
cord-002407-25cawzi0	449	58	-	-	HYPH
cord-002407-25cawzi0	449	59	attenuated	attenuate	VBN
cord-002407-25cawzi0	449	60	vaccines	vaccine	NNS
cord-002407-25cawzi0	449	61	Rearrangement	rearrangement	NN
cord-002407-25cawzi0	449	62	of	of	IN
cord-002407-25cawzi0	449	63	influenza	influenza	NN
cord-002407-25cawzi0	449	64	virus	virus	NN
cord-002407-25cawzi0	449	65	spliced	splice	VBN
cord-002407-25cawzi0	449	66	segments	segment	NNS
cord-002407-25cawzi0	449	67	for	for	IN
cord-002407-25cawzi0	449	68	the	the	DT
cord-002407-25cawzi0	449	69	development	development	NN
cord-002407-25cawzi0	449	70	of	of	IN
cord-002407-25cawzi0	449	71	live	live	RB
cord-002407-25cawzi0	449	72	-	-	HYPH
cord-002407-25cawzi0	449	73	attenuated	attenuate	VBN
cord-002407-25cawzi0	449	74	vaccines	vaccine	NNS
cord-002407-25cawzi0	449	75	H5N1	H5N1	NNP
cord-002407-25cawzi0	449	76	,	,	,
cord-002407-25cawzi0	449	77	a	a	DT
cord-002407-25cawzi0	449	78	wealth	wealth	NN
cord-002407-25cawzi0	449	79	of	of	IN
cord-002407-25cawzi0	449	80	knowledge	knowledge	NN
cord-002407-25cawzi0	449	81	to	to	TO
cord-002407-25cawzi0	449	82	improve	improve	VB
cord-002407-25cawzi0	449	83	pandemic	pandemic	NN
cord-002407-25cawzi0	449	84	preparedness	preparedness	NN
cord-002407-25cawzi0	449	85	Role	role	NN
cord-002407-25cawzi0	449	86	of	of	IN
cord-002407-25cawzi0	449	87	quail	quail	NNS
cord-002407-25cawzi0	449	88	in	in	IN
cord-002407-25cawzi0	449	89	the	the	DT
cord-002407-25cawzi0	449	90	interspecies	interspecie	NNS
cord-002407-25cawzi0	449	91	transmission	transmission	NN
cord-002407-25cawzi0	449	92	of	of	IN
cord-002407-25cawzi0	449	93	H9	H9	NNP
cord-002407-25cawzi0	449	94	influenza	influenza	NN
cord-002407-25cawzi0	449	95	A	a	DT
cord-002407-25cawzi0	449	96	viruses	virus	NNS
cord-002407-25cawzi0	450	1	:	:	:
cord-002407-25cawzi0	450	2	Molecular	molecular	JJ
cord-002407-25cawzi0	450	3	changes	change	NNS
cord-002407-25cawzi0	450	4	on	on	IN
cord-002407-25cawzi0	450	5	HA	HA	NNP
cord-002407-25cawzi0	450	6	that	that	WDT
cord-002407-25cawzi0	450	7	correspond	correspond	VBP
cord-002407-25cawzi0	450	8	to	to	IN
cord-002407-25cawzi0	450	9	adaptation	adaptation	NN
cord-002407-25cawzi0	450	10	from	from	IN
cord-002407-25cawzi0	450	11	ducks	duck	NNS
cord-002407-25cawzi0	450	12	to	to	IN
cord-002407-25cawzi0	450	13	chickens	chicken	NNS
cord-002407-25cawzi0	450	14	M2e	m2e	NN
cord-002407-25cawzi0	450	15	-	-	HYPH
cord-002407-25cawzi0	450	16	based	base	VBN
cord-002407-25cawzi0	450	17	universal	universal	JJ
cord-002407-25cawzi0	450	18	influenza	influenza	NN
cord-002407-25cawzi0	450	19	A	a	DT
cord-002407-25cawzi0	450	20	vaccines	vaccine	NNS
cord-002407-25cawzi0	450	21	Structure	Structure	NNP
cord-002407-25cawzi0	450	22	of	of	IN
cord-002407-25cawzi0	450	23	the	the	DT
cord-002407-25cawzi0	450	24	haemagglutinin	haemagglutinin	NNP
cord-002407-25cawzi0	450	25	membrane	membrane	NN
cord-002407-25cawzi0	450	26	glycoprotein	glycoprotein	NN
cord-002407-25cawzi0	450	27	of	of	IN
cord-002407-25cawzi0	450	28	influenza	influenza	NN
cord-002407-25cawzi0	450	29	virus	virus	NN
cord-002407-25cawzi0	450	30	at	at	IN
cord-002407-25cawzi0	450	31	3	3	CD
cord-002407-25cawzi0	450	32	A	a	DT
cord-002407-25cawzi0	450	33	resolution	resolution	NN
cord-002407-25cawzi0	450	34	Universal	Universal	NNP
cord-002407-25cawzi0	450	35	influenza	influenza	NN
cord-002407-25cawzi0	450	36	vaccines	vaccine	NNS
cord-002407-25cawzi0	450	37	,	,	,
cord-002407-25cawzi0	450	38	a	a	DT
cord-002407-25cawzi0	450	39	dream	dream	NN
cord-002407-25cawzi0	450	40	to	to	TO
cord-002407-25cawzi0	450	41	be	be	VB
cord-002407-25cawzi0	450	42	realized	realize	VBN
cord-002407-25cawzi0	450	43	soon	soon	RB
cord-002407-25cawzi0	451	1	In	in	IN
cord-002407-25cawzi0	451	2	vitro	vitro	FW
cord-002407-25cawzi0	451	3	stimulation	stimulation	NN
cord-002407-25cawzi0	451	4	of	of	IN
cord-002407-25cawzi0	451	5	human	human	JJ
cord-002407-25cawzi0	451	6	influenza	influenza	NN
cord-002407-25cawzi0	451	7	-	-	HYPH
cord-002407-25cawzi0	451	8	specific	specific	JJ
cord-002407-25cawzi0	451	9	CD8	CD8	NNP
cord-002407-25cawzi0	451	10	+	+	CC
cord-002407-25cawzi0	451	11	T	t	NN
cord-002407-25cawzi0	451	12	cells	cell	NNS
cord-002407-25cawzi0	451	13	by	by	IN
cord-002407-25cawzi0	451	14	dendritic	dendritic	JJ
cord-002407-25cawzi0	451	15	cells	cell	NNS
cord-002407-25cawzi0	451	16	pulsed	pulse	VBN
cord-002407-25cawzi0	451	17	with	with	IN
cord-002407-25cawzi0	451	18	an	an	DT
cord-002407-25cawzi0	451	19	influenza	influenza	NN
cord-002407-25cawzi0	451	20	virus	virus	NN
cord-002407-25cawzi0	451	21	-	-	HYPH
cord-002407-25cawzi0	451	22	like	like	JJ
cord-002407-25cawzi0	451	23	particle	particle	NN
cord-002407-25cawzi0	451	24	(	(	-LRB-
cord-002407-25cawzi0	451	25	VLP	VLP	NNP
cord-002407-25cawzi0	451	26	)	)	-RRB-
cord-002407-25cawzi0	451	27	vaccine	vaccine	NN
cord-002407-25cawzi0	451	28	.	.	.
cord-002407-25cawzi0	452	1	Vaccine	Vaccine	NNP
cord-002407-25cawzi0	452	2	Formation	Formation	NNP
cord-002407-25cawzi0	452	3	of	of	IN
cord-002407-25cawzi0	452	4	wild	wild	JJ
cord-002407-25cawzi0	452	5	-	-	HYPH
cord-002407-25cawzi0	452	6	type	type	NN
cord-002407-25cawzi0	452	7	and	and	CC
cord-002407-25cawzi0	452	8	chimeric	chimeric	JJ
cord-002407-25cawzi0	452	9	influenza	influenza	NN
cord-002407-25cawzi0	452	10	virus	virus	NN
cord-002407-25cawzi0	452	11	-	-	HYPH
cord-002407-25cawzi0	452	12	like	like	JJ
cord-002407-25cawzi0	452	13	particles	particle	NNS
cord-002407-25cawzi0	452	14	following	follow	VBG
cord-002407-25cawzi0	452	15	simultaneous	simultaneous	JJ
cord-002407-25cawzi0	452	16	expression	expression	NN
cord-002407-25cawzi0	452	17	of	of	IN
cord-002407-25cawzi0	452	18	only	only	RB
cord-002407-25cawzi0	452	19	four	four	CD
cord-002407-25cawzi0	452	20	structural	structural	JJ
cord-002407-25cawzi0	452	21	proteins	protein	NNS
cord-002407-25cawzi0	452	22	Influenza	Influenza	NNP
cord-002407-25cawzi0	452	23	virus	virus	NN
cord-002407-25cawzi0	452	24	-	-	HYPH
cord-002407-25cawzi0	452	25	like	like	JJ
cord-002407-25cawzi0	452	26	particles	particle	NNS
cord-002407-25cawzi0	452	27	comprised	comprise	VBN
cord-002407-25cawzi0	452	28	of	of	IN
cord-002407-25cawzi0	452	29	the	the	DT
cord-002407-25cawzi0	452	30	HA	HA	NNP
cord-002407-25cawzi0	452	31	,	,	,
cord-002407-25cawzi0	452	32	NA	NA	NNP
cord-002407-25cawzi0	452	33	,	,	,
cord-002407-25cawzi0	452	34	and	and	CC
cord-002407-25cawzi0	452	35	M1	M1	NNP
cord-002407-25cawzi0	452	36	proteins	protein	NNS
cord-002407-25cawzi0	452	37	of	of	IN
cord-002407-25cawzi0	452	38	H9N2	H9N2	NNP
cord-002407-25cawzi0	452	39	influenza	influenza	NN
cord-002407-25cawzi0	452	40	virus	virus	NN
cord-002407-25cawzi0	452	41	induce	induce	VBP
cord-002407-25cawzi0	452	42	protective	protective	JJ
cord-002407-25cawzi0	452	43	immune	immune	JJ
cord-002407-25cawzi0	452	44	responses	response	NNS
cord-002407-25cawzi0	452	45	in	in	IN
cord-002407-25cawzi0	452	46	BALB	BALB	NNP
cord-002407-25cawzi0	452	47	/	/	SYM
cord-002407-25cawzi0	452	48	c	c	NN
cord-002407-25cawzi0	452	49	mice	mouse	NNS
cord-002407-25cawzi0	452	50	Influenza	Influenza	NNP
cord-002407-25cawzi0	452	51	virus	virus	NN
cord-002407-25cawzi0	452	52	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	452	53	and	and	CC
cord-002407-25cawzi0	452	54	neuraminidase	neuraminidase	NN
cord-002407-25cawzi0	452	55	,	,	,
cord-002407-25cawzi0	452	56	but	but	CC
cord-002407-25cawzi0	452	57	not	not	RB
cord-002407-25cawzi0	452	58	the	the	DT
cord-002407-25cawzi0	452	59	matrix	matrix	NN
cord-002407-25cawzi0	452	60	protein	protein	NN
cord-002407-25cawzi0	452	61	,	,	,
cord-002407-25cawzi0	452	62	are	be	VBP
cord-002407-25cawzi0	452	63	required	require	VBN
cord-002407-25cawzi0	452	64	for	for	IN
cord-002407-25cawzi0	452	65	assembly	assembly	NN
cord-002407-25cawzi0	452	66	and	and	CC
cord-002407-25cawzi0	452	67	budding	budding	NN
cord-002407-25cawzi0	452	68	of	of	IN
cord-002407-25cawzi0	452	69	plasmid	plasmid	NN
cord-002407-25cawzi0	452	70	-	-	HYPH
cord-002407-25cawzi0	452	71	derived	derive	VBN
cord-002407-25cawzi0	452	72	virus	virus	NN
cord-002407-25cawzi0	452	73	-	-	HYPH
cord-002407-25cawzi0	452	74	like	like	JJ
cord-002407-25cawzi0	452	75	particles	particle	NNS
cord-002407-25cawzi0	452	76	Influenza	Influenza	NNP
cord-002407-25cawzi0	452	77	virus	virus	NN
cord-002407-25cawzi0	452	78	-	-	HYPH
cord-002407-25cawzi0	452	79	like	like	JJ
cord-002407-25cawzi0	452	80	particle	particle	NN
cord-002407-25cawzi0	452	81	can	can	MD
cord-002407-25cawzi0	452	82	accommodate	accommodate	VB
cord-002407-25cawzi0	452	83	multiple	multiple	JJ
cord-002407-25cawzi0	452	84	subtypes	subtype	NNS
cord-002407-25cawzi0	452	85	of	of	IN
cord-002407-25cawzi0	452	86	hemagglutinin	hemagglutinin	NN
cord-002407-25cawzi0	452	87	and	and	CC
cord-002407-25cawzi0	452	88	protect	protect	VB
cord-002407-25cawzi0	452	89	from	from	IN
cord-002407-25cawzi0	452	90	multiple	multiple	JJ
cord-002407-25cawzi0	452	91	influenza	influenza	NN
cord-002407-25cawzi0	452	92	types	type	NNS
cord-002407-25cawzi0	452	93	and	and	CC
cord-002407-25cawzi0	452	94	subtypes	subtype	NNS