id	sid	tid	token	lemma	pos
cord-003567-h8uq5z8b	1	1	key	key	JJ
cord-003567-h8uq5z8b	1	2	:	:	:
cord-003567-h8uq5z8b	1	3	cord-003567-h8uq5z8b	cord-003567-h8uq5z8b	NN
cord-003567-h8uq5z8b	1	4	authors	author	NNS
cord-003567-h8uq5z8b	1	5	:	:	:
cord-003567-h8uq5z8b	1	6	Crank	crank	VB
cord-003567-h8uq5z8b	1	7	,	,	,
cord-003567-h8uq5z8b	1	8	Michelle	Michelle	NNP
cord-003567-h8uq5z8b	1	9	C	C	NNP
cord-003567-h8uq5z8b	1	10	;	;	:
cord-003567-h8uq5z8b	1	11	Mascola	Mascola	NNP
cord-003567-h8uq5z8b	1	12	,	,	,
cord-003567-h8uq5z8b	1	13	John	John	NNP
cord-003567-h8uq5z8b	1	14	R	R	NNP
cord-003567-h8uq5z8b	1	15	;	;	:
cord-003567-h8uq5z8b	1	16	Graham	Graham	NNP
cord-003567-h8uq5z8b	1	17	,	,	,
cord-003567-h8uq5z8b	1	18	Barney	Barney	NNP
cord-003567-h8uq5z8b	1	19	S	S	NNP
cord-003567-h8uq5z8b	1	20	title	title	NN
cord-003567-h8uq5z8b	1	21	:	:	:
cord-003567-h8uq5z8b	1	22	Preparing	prepare	VBG
cord-003567-h8uq5z8b	1	23	for	for	IN
cord-003567-h8uq5z8b	1	24	the	the	DT
cord-003567-h8uq5z8b	1	25	Next	Next	NNP
cord-003567-h8uq5z8b	1	26	Influenza	Influenza	NNP
cord-003567-h8uq5z8b	1	27	Pandemic	Pandemic	NNP
cord-003567-h8uq5z8b	1	28	:	:	:
cord-003567-h8uq5z8b	1	29	The	the	DT
cord-003567-h8uq5z8b	1	30	Development	Development	NNP
cord-003567-h8uq5z8b	1	31	of	of	IN
cord-003567-h8uq5z8b	1	32	a	a	DT
cord-003567-h8uq5z8b	1	33	Universal	Universal	NNP
cord-003567-h8uq5z8b	1	34	Influenza	Influenza	NNP
cord-003567-h8uq5z8b	1	35	Vaccine	Vaccine	NNP
cord-003567-h8uq5z8b	1	36	date	date	NN
cord-003567-h8uq5z8b	1	37	:	:	:
cord-003567-h8uq5z8b	1	38	2019	2019	CD
cord-003567-h8uq5z8b	1	39	-	-	HYPH
cord-003567-h8uq5z8b	1	40	04	04	CD
cord-003567-h8uq5z8b	1	41	-	-	SYM
cord-003567-h8uq5z8b	1	42	15	15	CD
cord-003567-h8uq5z8b	1	43	journal	journal	NN
cord-003567-h8uq5z8b	1	44	:	:	:
cord-003567-h8uq5z8b	2	1	J	J	NNP
cord-003567-h8uq5z8b	2	2	Infect	infect	VBP
cord-003567-h8uq5z8b	2	3	Dis	Dis	NNP
cord-003567-h8uq5z8b	2	4	DOI	doi	NN
cord-003567-h8uq5z8b	2	5	:	:	:
cord-003567-h8uq5z8b	2	6	10.1093	10.1093	CD
cord-003567-h8uq5z8b	2	7	/	/	SYM
cord-003567-h8uq5z8b	2	8	infdis	infdis	NN
cord-003567-h8uq5z8b	2	9	/	/	SYM
cord-003567-h8uq5z8b	2	10	jiz043	jiz043	NNP
cord-003567-h8uq5z8b	2	11	sha	sha	NNP
cord-003567-h8uq5z8b	2	12	:	:	:
cord-003567-h8uq5z8b	3	1	edfb998eace3313bfa399de661b49a22197ffd51	edfb998eace3313bfa399de661b49a22197ffd51	NNP
cord-003567-h8uq5z8b	3	2	doc_id	doc_id	NNPS
cord-003567-h8uq5z8b	4	1	:	:	:
cord-003567-h8uq5z8b	4	2	3567	3567	CD
cord-003567-h8uq5z8b	4	3	cord_uid	cord_uid	NNS
cord-003567-h8uq5z8b	4	4	:	:	:
cord-003567-h8uq5z8b	4	5	h8uq5z8b	h8uq5z8b	NNP
cord-003567-h8uq5z8b	4	6	nan	nan	NNP
cord-003567-h8uq5z8b	4	7	structural	structural	JJ
cord-003567-h8uq5z8b	4	8	biology	biology	NN
cord-003567-h8uq5z8b	4	9	,	,	,
cord-003567-h8uq5z8b	4	10	protein	protein	NN
cord-003567-h8uq5z8b	4	11	engineering	engineering	NN
cord-003567-h8uq5z8b	4	12	,	,	,
cord-003567-h8uq5z8b	4	13	and	and	CC
cord-003567-h8uq5z8b	4	14	antigen	antigen	NN
cord-003567-h8uq5z8b	4	15	delivery	delivery	NN
cord-003567-h8uq5z8b	4	16	amenable	amenable	JJ
cord-003567-h8uq5z8b	4	17	to	to	IN
cord-003567-h8uq5z8b	4	18	platform	platform	NN
cord-003567-h8uq5z8b	4	19	manufacturing	manufacturing	NN
cord-003567-h8uq5z8b	4	20	approaches	approach	NNS
cord-003567-h8uq5z8b	4	21	.	.	.
cord-003567-h8uq5z8b	5	1	Molecularand	Molecularand	NNP
cord-003567-h8uq5z8b	5	2	atomic	atomic	JJ
cord-003567-h8uq5z8b	5	3	-	-	HYPH
cord-003567-h8uq5z8b	5	4	level	level	NN
cord-003567-h8uq5z8b	5	5	information	information	NN
cord-003567-h8uq5z8b	5	6	about	about	IN
cord-003567-h8uq5z8b	5	7	the	the	DT
cord-003567-h8uq5z8b	5	8	immune	immune	JJ
cord-003567-h8uq5z8b	5	9	-	-	HYPH
cord-003567-h8uq5z8b	5	10	viral	viral	JJ
cord-003567-h8uq5z8b	5	11	interface	interface	NN
cord-003567-h8uq5z8b	5	12	combined	combine	VBN
cord-003567-h8uq5z8b	5	13	with	with	IN
cord-003567-h8uq5z8b	5	14	new	new	JJ
cord-003567-h8uq5z8b	5	15	capacities	capacity	NNS
cord-003567-h8uq5z8b	5	16	for	for	IN
cord-003567-h8uq5z8b	5	17	surveillance	surveillance	NN
cord-003567-h8uq5z8b	5	18	and	and	CC
cord-003567-h8uq5z8b	5	19	rapid	rapid	JJ
cord-003567-h8uq5z8b	5	20	response	response	NN
cord-003567-h8uq5z8b	5	21	to	to	IN
cord-003567-h8uq5z8b	5	22	pandemics	pandemic	NNS
cord-003567-h8uq5z8b	5	23	are	be	VBP
cord-003567-h8uq5z8b	5	24	shaping	shape	VBG
cord-003567-h8uq5z8b	5	25	a	a	DT
cord-003567-h8uq5z8b	5	26	new	new	JJ
cord-003567-h8uq5z8b	5	27	conceptual	conceptual	JJ
cord-003567-h8uq5z8b	5	28	framework	framework	NN
cord-003567-h8uq5z8b	5	29	for	for	IN
cord-003567-h8uq5z8b	5	30	vaccine	vaccine	NN
cord-003567-h8uq5z8b	5	31	development	development	NN
cord-003567-h8uq5z8b	5	32	.	.	.
cord-003567-h8uq5z8b	6	1	As	as	IN
cord-003567-h8uq5z8b	6	2	a	a	DT
cord-003567-h8uq5z8b	6	3	result	result	NN
cord-003567-h8uq5z8b	6	4	of	of	IN
cord-003567-h8uq5z8b	6	5	these	these	DT
cord-003567-h8uq5z8b	6	6	advances	advance	NNS
cord-003567-h8uq5z8b	6	7	,	,	,
cord-003567-h8uq5z8b	6	8	highlevel	highlevel	JJ
cord-003567-h8uq5z8b	6	9	,	,	,
cord-003567-h8uq5z8b	6	10	broad	broad	JJ
cord-003567-h8uq5z8b	6	11	,	,	,
cord-003567-h8uq5z8b	6	12	and	and	CC
cord-003567-h8uq5z8b	6	13	durable	durable	JJ
cord-003567-h8uq5z8b	6	14	immunity	immunity	NN
cord-003567-h8uq5z8b	6	15	against	against	IN
cord-003567-h8uq5z8b	6	16	the	the	DT
cord-003567-h8uq5z8b	6	17	large	large	JJ
cord-003567-h8uq5z8b	6	18	universe	universe	NN
cord-003567-h8uq5z8b	6	19	of	of	IN
cord-003567-h8uq5z8b	6	20	influenza	influenza	NN
cord-003567-h8uq5z8b	6	21	viruses	virus	NNS
cord-003567-h8uq5z8b	6	22	may	may	MD
cord-003567-h8uq5z8b	6	23	now	now	RB
cord-003567-h8uq5z8b	6	24	be	be	VB
cord-003567-h8uq5z8b	6	25	within	within	IN
cord-003567-h8uq5z8b	6	26	reach	reach	NN
cord-003567-h8uq5z8b	6	27	[	[	-LRB-
cord-003567-h8uq5z8b	6	28	20	20	CD
cord-003567-h8uq5z8b	6	29	]	]	-RRB-
cord-003567-h8uq5z8b	6	30	.	.	.
cord-003567-h8uq5z8b	7	1	This	this	DT
cord-003567-h8uq5z8b	7	2	issue	issue	NN
cord-003567-h8uq5z8b	7	3	of	of	IN
cord-003567-h8uq5z8b	7	4	The	the	DT
cord-003567-h8uq5z8b	7	5	Journal	Journal	NNP
cord-003567-h8uq5z8b	7	6	of	of	IN
cord-003567-h8uq5z8b	7	7	Infectious	Infectious	NNP
cord-003567-h8uq5z8b	7	8	Diseases	Diseases	NNPS
cord-003567-h8uq5z8b	7	9	was	be	VBD
cord-003567-h8uq5z8b	7	10	motivated	motivate	VBN
cord-003567-h8uq5z8b	7	11	by	by	IN
cord-003567-h8uq5z8b	7	12	the	the	DT
cord-003567-h8uq5z8b	7	13	confluence	confluence	NN
cord-003567-h8uq5z8b	7	14	of	of	IN
cord-003567-h8uq5z8b	7	15	the	the	DT
cord-003567-h8uq5z8b	7	16	1918	1918	CD
cord-003567-h8uq5z8b	7	17	influenza	influenza	NN
cord-003567-h8uq5z8b	7	18	pandemic	pandemic	NNP
cord-003567-h8uq5z8b	7	19	centenary	centenary	NN
cord-003567-h8uq5z8b	7	20	and	and	CC
cord-003567-h8uq5z8b	7	21	the	the	DT
cord-003567-h8uq5z8b	7	22	new	new	JJ
cord-003567-h8uq5z8b	7	23	opportunities	opportunity	NNS
cord-003567-h8uq5z8b	7	24	afforded	afford	VBN
cord-003567-h8uq5z8b	7	25	by	by	IN
cord-003567-h8uq5z8b	7	26	technological	technological	JJ
cord-003567-h8uq5z8b	7	27	advances	advance	NNS
cord-003567-h8uq5z8b	7	28	and	and	CC
cord-003567-h8uq5z8b	7	29	breakthroughs	breakthrough	NNS
cord-003567-h8uq5z8b	7	30	along	along	IN
cord-003567-h8uq5z8b	7	31	with	with	IN
cord-003567-h8uq5z8b	7	32	the	the	DT
cord-003567-h8uq5z8b	7	33	improved	improved	JJ
cord-003567-h8uq5z8b	7	34	understanding	understanding	NN
cord-003567-h8uq5z8b	7	35	of	of	IN
cord-003567-h8uq5z8b	7	36	influenza	influenza	NN
cord-003567-h8uq5z8b	7	37	biology	biology	NN
cord-003567-h8uq5z8b	7	38	.	.	.
cord-003567-h8uq5z8b	8	1	We	-PRON-	PRP
cord-003567-h8uq5z8b	8	2	have	have	VBP
cord-003567-h8uq5z8b	8	3	gathered	gather	VBN
cord-003567-h8uq5z8b	8	4	information	information	NN
cord-003567-h8uq5z8b	8	5	,	,	,
cord-003567-h8uq5z8b	8	6	opinions	opinion	NNS
cord-003567-h8uq5z8b	8	7	,	,	,
cord-003567-h8uq5z8b	8	8	and	and	CC
cord-003567-h8uq5z8b	8	9	ideas	idea	NNS
cord-003567-h8uq5z8b	8	10	from	from	IN
cord-003567-h8uq5z8b	8	11	thought	thought	NN
cord-003567-h8uq5z8b	8	12	leaders	leader	NNS
cord-003567-h8uq5z8b	8	13	in	in	IN
cord-003567-h8uq5z8b	8	14	immunology	immunology	NN
cord-003567-h8uq5z8b	8	15	,	,	,
cord-003567-h8uq5z8b	8	16	virology	virology	NN
cord-003567-h8uq5z8b	8	17	,	,	,
cord-003567-h8uq5z8b	8	18	epidemiology	epidemiology	NN
cord-003567-h8uq5z8b	8	19	,	,	,
cord-003567-h8uq5z8b	8	20	and	and	CC
cord-003567-h8uq5z8b	8	21	vaccinology	vaccinology	NN
cord-003567-h8uq5z8b	8	22	to	to	TO
cord-003567-h8uq5z8b	8	23	address	address	VB
cord-003567-h8uq5z8b	8	24	the	the	DT
cord-003567-h8uq5z8b	8	25	challenge	challenge	NN
cord-003567-h8uq5z8b	8	26	of	of	IN
cord-003567-h8uq5z8b	8	27	developing	develop	VBG
cord-003567-h8uq5z8b	8	28	a	a	DT
cord-003567-h8uq5z8b	8	29	universal	universal	JJ
cord-003567-h8uq5z8b	8	30	influenza	influenza	NN
cord-003567-h8uq5z8b	8	31	vaccine	vaccine	NN
cord-003567-h8uq5z8b	8	32	and	and	CC
cord-003567-h8uq5z8b	8	33	articulate	articulate	VB
cord-003567-h8uq5z8b	8	34	some	some	DT
cord-003567-h8uq5z8b	8	35	of	of	IN
cord-003567-h8uq5z8b	8	36	the	the	DT
cord-003567-h8uq5z8b	8	37	knowledge	knowledge	NN
cord-003567-h8uq5z8b	8	38	and	and	CC
cord-003567-h8uq5z8b	8	39	technical	technical	JJ
cord-003567-h8uq5z8b	8	40	gaps	gap	NNS
cord-003567-h8uq5z8b	8	41	that	that	WDT
cord-003567-h8uq5z8b	8	42	remain	remain	VBP
cord-003567-h8uq5z8b	8	43	.	.	.
cord-003567-h8uq5z8b	9	1	In	in	IN
cord-003567-h8uq5z8b	9	2	1918	1918	CD
cord-003567-h8uq5z8b	9	3	,	,	,
cord-003567-h8uq5z8b	9	4	there	there	EX
cord-003567-h8uq5z8b	9	5	were	be	VBD
cord-003567-h8uq5z8b	9	6	approximately	approximately	RB
cord-003567-h8uq5z8b	9	7	1.8	1.8	CD
cord-003567-h8uq5z8b	9	8	billion	billion	CD
cord-003567-h8uq5z8b	9	9	persons	person	NNS
cord-003567-h8uq5z8b	9	10	living	live	VBG
cord-003567-h8uq5z8b	9	11	on	on	IN
cord-003567-h8uq5z8b	9	12	earth	earth	NN
cord-003567-h8uq5z8b	9	13	;	;	,
cord-003567-h8uq5z8b	9	14	today	today	NN
cord-003567-h8uq5z8b	9	15	,	,	,
cord-003567-h8uq5z8b	9	16	there	there	EX
cord-003567-h8uq5z8b	9	17	are	be	VBP
cord-003567-h8uq5z8b	9	18	more	more	JJR
cord-003567-h8uq5z8b	9	19	than	than	IN
cord-003567-h8uq5z8b	9	20	7	7	CD
cord-003567-h8uq5z8b	9	21	billion	billion	CD
cord-003567-h8uq5z8b	9	22	[	[	-LRB-
cord-003567-h8uq5z8b	9	23	21	21	CD
cord-003567-h8uq5z8b	9	24	]	]	-RRB-
cord-003567-h8uq5z8b	9	25	.	.	.
cord-003567-h8uq5z8b	10	1	If	if	IN
cord-003567-h8uq5z8b	10	2	a	a	DT
cord-003567-h8uq5z8b	10	3	pandemic	pandemic	NN
cord-003567-h8uq5z8b	10	4	similar	similar	JJ
cord-003567-h8uq5z8b	10	5	to	to	IN
cord-003567-h8uq5z8b	10	6	that	that	DT
cord-003567-h8uq5z8b	10	7	of	of	IN
cord-003567-h8uq5z8b	10	8	1918	1918	CD
cord-003567-h8uq5z8b	10	9	occurred	occur	VBD
cord-003567-h8uq5z8b	10	10	today	today	NN
cord-003567-h8uq5z8b	10	11	,	,	,
cord-003567-h8uq5z8b	10	12	how	how	WRB
cord-003567-h8uq5z8b	10	13	would	would	MD
cord-003567-h8uq5z8b	10	14	the	the	DT
cord-003567-h8uq5z8b	10	15	devastation	devastation	NN
cord-003567-h8uq5z8b	10	16	compare	compare	VB
cord-003567-h8uq5z8b	10	17	?	?	.
cord-003567-h8uq5z8b	11	1	Because	because	IN
cord-003567-h8uq5z8b	11	2	of	of	IN
cord-003567-h8uq5z8b	11	3	rapid	rapid	JJ
cord-003567-h8uq5z8b	11	4	international	international	JJ
cord-003567-h8uq5z8b	11	5	travel	travel	NN
cord-003567-h8uq5z8b	11	6	,	,	,
cord-003567-h8uq5z8b	11	7	the	the	DT
cord-003567-h8uq5z8b	11	8	spread	spread	NN
cord-003567-h8uq5z8b	11	9	of	of	IN
cord-003567-h8uq5z8b	11	10	a	a	DT
cord-003567-h8uq5z8b	11	11	new	new	JJ
cord-003567-h8uq5z8b	11	12	virus	virus	NN
cord-003567-h8uq5z8b	11	13	would	would	MD
cord-003567-h8uq5z8b	11	14	be	be	VB
cord-003567-h8uq5z8b	11	15	faster	fast	JJR
cord-003567-h8uq5z8b	11	16	than	than	IN
cord-003567-h8uq5z8b	11	17	it	-PRON-	PRP
cord-003567-h8uq5z8b	11	18	was	be	VBD
cord-003567-h8uq5z8b	11	19	in	in	IN
cord-003567-h8uq5z8b	11	20	1918	1918	CD
cord-003567-h8uq5z8b	11	21	,	,	,
cord-003567-h8uq5z8b	12	1	when	when	WRB
cord-003567-h8uq5z8b	12	2	spread	spread	VBN
cord-003567-h8uq5z8b	12	3	was	be	VBD
cord-003567-h8uq5z8b	12	4	largely	largely	RB
cord-003567-h8uq5z8b	12	5	related	relate	VBN
cord-003567-h8uq5z8b	12	6	to	to	IN
cord-003567-h8uq5z8b	12	7	the	the	DT
cord-003567-h8uq5z8b	12	8	movement	movement	NN
cord-003567-h8uq5z8b	12	9	of	of	IN
cord-003567-h8uq5z8b	12	10	troops	troop	NNS
cord-003567-h8uq5z8b	12	11	at	at	IN
cord-003567-h8uq5z8b	12	12	the	the	DT
cord-003567-h8uq5z8b	12	13	end	end	NN
cord-003567-h8uq5z8b	12	14	of	of	IN
cord-003567-h8uq5z8b	12	15	World	World	NNP
cord-003567-h8uq5z8b	12	16	War	War	NNP
cord-003567-h8uq5z8b	12	17	I.	I.	NNP
cord-003567-h8uq5z8b	12	18	Today	today	NN
cord-003567-h8uq5z8b	12	19	,	,	,
cord-003567-h8uq5z8b	12	20	population	population	NN
cord-003567-h8uq5z8b	12	21	density	density	NN
cord-003567-h8uq5z8b	12	22	is	be	VBZ
cord-003567-h8uq5z8b	12	23	higher	high	JJR
cord-003567-h8uq5z8b	12	24	and	and	CC
cord-003567-h8uq5z8b	12	25	cities	city	NNS
cord-003567-h8uq5z8b	12	26	are	be	VBP
cord-003567-h8uq5z8b	12	27	larger	large	JJR
cord-003567-h8uq5z8b	12	28	,	,	,
cord-003567-h8uq5z8b	12	29	providing	provide	VBG
cord-003567-h8uq5z8b	12	30	a	a	DT
cord-003567-h8uq5z8b	12	31	more	more	RBR
cord-003567-h8uq5z8b	12	32	favorable	favorable	JJ
cord-003567-h8uq5z8b	12	33	environment	environment	NN
cord-003567-h8uq5z8b	12	34	for	for	IN
cord-003567-h8uq5z8b	12	35	a	a	DT
cord-003567-h8uq5z8b	12	36	rapidly	rapidly	RB
cord-003567-h8uq5z8b	12	37	spreading	spread	VBG
cord-003567-h8uq5z8b	12	38	virus	virus	NN
cord-003567-h8uq5z8b	12	39	.	.	.
cord-003567-h8uq5z8b	13	1	Although	although	IN
cord-003567-h8uq5z8b	13	2	we	-PRON-	PRP
cord-003567-h8uq5z8b	13	3	now	now	RB
cord-003567-h8uq5z8b	13	4	have	have	VBP
cord-003567-h8uq5z8b	13	5	more	more	RBR
cord-003567-h8uq5z8b	13	6	sophisticated	sophisticated	JJ
cord-003567-h8uq5z8b	13	7	medical	medical	JJ
cord-003567-h8uq5z8b	13	8	care	care	NN
cord-003567-h8uq5z8b	13	9	,	,	,
cord-003567-h8uq5z8b	13	10	the	the	DT
cord-003567-h8uq5z8b	13	11	availability	availability	NN
cord-003567-h8uq5z8b	13	12	of	of	IN
cord-003567-h8uq5z8b	13	13	hospital	hospital	NN
cord-003567-h8uq5z8b	13	14	beds	bed	NNS
cord-003567-h8uq5z8b	13	15	and	and	CC
cord-003567-h8uq5z8b	13	16	life	life	NN
cord-003567-h8uq5z8b	13	17	support	support	NN
cord-003567-h8uq5z8b	13	18	equipment	equipment	NN
cord-003567-h8uq5z8b	13	19	would	would	MD
cord-003567-h8uq5z8b	13	20	probably	probably	RB
cord-003567-h8uq5z8b	13	21	not	not	RB
cord-003567-h8uq5z8b	13	22	be	be	VB
cord-003567-h8uq5z8b	13	23	sufficient	sufficient	JJ
cord-003567-h8uq5z8b	13	24	to	to	TO
cord-003567-h8uq5z8b	13	25	manage	manage	VB
cord-003567-h8uq5z8b	13	26	an	an	DT
cord-003567-h8uq5z8b	13	27	outbreak	outbreak	NN
cord-003567-h8uq5z8b	13	28	equivalent	equivalent	JJ
cord-003567-h8uq5z8b	13	29	in	in	IN
cord-003567-h8uq5z8b	13	30	magnitude	magnitude	NN
cord-003567-h8uq5z8b	13	31	to	to	IN
cord-003567-h8uq5z8b	13	32	that	that	DT
cord-003567-h8uq5z8b	13	33	of	of	IN
cord-003567-h8uq5z8b	13	34	1918	1918	CD
cord-003567-h8uq5z8b	13	35	.	.	.
cord-003567-h8uq5z8b	14	1	If	if	IN
cord-003567-h8uq5z8b	14	2	there	there	EX
cord-003567-h8uq5z8b	14	3	were	be	VBD
cord-003567-h8uq5z8b	14	4	sentinel	sentinel	JJ
cord-003567-h8uq5z8b	14	5	events	event	NNS
cord-003567-h8uq5z8b	14	6	as	as	IN
cord-003567-h8uq5z8b	14	7	in	in	IN
cord-003567-h8uq5z8b	14	8	1918	1918	CD
cord-003567-h8uq5z8b	14	9	and	and	CC
cord-003567-h8uq5z8b	14	10	in	in	IN
cord-003567-h8uq5z8b	14	11	2009-a	2009-a	CD
cord-003567-h8uq5z8b	14	12	small	small	JJ
cord-003567-h8uq5z8b	14	13	spring	spring	NN
cord-003567-h8uq5z8b	14	14	epidemic	epidemic	NN
cord-003567-h8uq5z8b	14	15	preceding	precede	VBG
cord-003567-h8uq5z8b	14	16	the	the	DT
cord-003567-h8uq5z8b	14	17	fall	fall	NN
cord-003567-h8uq5z8b	14	18	pandemic	pandemic	NN
cord-003567-h8uq5z8b	14	19	-	-	HYPH
cord-003567-h8uq5z8b	14	20	current	current	JJ
cord-003567-h8uq5z8b	14	21	vaccine	vaccine	NN
cord-003567-h8uq5z8b	14	22	manufacturing	manufacturing	NN
cord-003567-h8uq5z8b	14	23	approaches	approach	NNS
cord-003567-h8uq5z8b	14	24	would	would	MD
cord-003567-h8uq5z8b	14	25	not	not	RB
cord-003567-h8uq5z8b	14	26	be	be	VB
cord-003567-h8uq5z8b	14	27	sufficiently	sufficiently	RB
cord-003567-h8uq5z8b	14	28	fast	fast	JJ
cord-003567-h8uq5z8b	14	29	or	or	CC
cord-003567-h8uq5z8b	14	30	scalable	scalable	JJ
cord-003567-h8uq5z8b	14	31	for	for	IN
cord-003567-h8uq5z8b	14	32	worldwide	worldwide	JJ
cord-003567-h8uq5z8b	14	33	distribution	distribution	NN
cord-003567-h8uq5z8b	14	34	to	to	TO
cord-003567-h8uq5z8b	14	35	preempt	preempt	VB
cord-003567-h8uq5z8b	14	36	pandemic	pandemic	NN
cord-003567-h8uq5z8b	14	37	spread	spread	VBN
cord-003567-h8uq5z8b	14	38	.	.	.
cord-003567-h8uq5z8b	15	1	Therefore	therefore	RB
cord-003567-h8uq5z8b	15	2	,	,	,
cord-003567-h8uq5z8b	15	3	development	development	NN
cord-003567-h8uq5z8b	15	4	of	of	IN
cord-003567-h8uq5z8b	15	5	a	a	DT
cord-003567-h8uq5z8b	15	6	universal	universal	JJ
cord-003567-h8uq5z8b	15	7	influenza	influenza	NN
cord-003567-h8uq5z8b	15	8	vaccine	vaccine	NN
cord-003567-h8uq5z8b	15	9	that	that	WDT
cord-003567-h8uq5z8b	15	10	can	can	MD
cord-003567-h8uq5z8b	15	11	reliably	reliably	RB
cord-003567-h8uq5z8b	15	12	protect	protect	VB
cord-003567-h8uq5z8b	15	13	against	against	IN
cord-003567-h8uq5z8b	15	14	drifted	drift	VBN
cord-003567-h8uq5z8b	15	15	seasonal	seasonal	JJ
cord-003567-h8uq5z8b	15	16	strains	strain	NNS
cord-003567-h8uq5z8b	15	17	and	and	CC
cord-003567-h8uq5z8b	15	18	pandemic	pandemic	NN
cord-003567-h8uq5z8b	15	19	strains	strain	NNS
cord-003567-h8uq5z8b	15	20	without	without	IN
cord-003567-h8uq5z8b	15	21	biannual	biannual	JJ
cord-003567-h8uq5z8b	15	22	reformulation	reformulation	NN
cord-003567-h8uq5z8b	15	23	is	be	VBZ
cord-003567-h8uq5z8b	15	24	imperative	imperative	JJ
cord-003567-h8uq5z8b	15	25	.	.	.
cord-003567-h8uq5z8b	16	1	Ideally	ideally	RB
cord-003567-h8uq5z8b	16	2	,	,	,
cord-003567-h8uq5z8b	16	3	this	this	DT
cord-003567-h8uq5z8b	16	4	vaccine	vaccine	NN
cord-003567-h8uq5z8b	16	5	would	would	MD
cord-003567-h8uq5z8b	16	6	not	not	RB
cord-003567-h8uq5z8b	16	7	need	need	VB
cord-003567-h8uq5z8b	16	8	to	to	TO
cord-003567-h8uq5z8b	16	9	be	be	VB
cord-003567-h8uq5z8b	16	10	given	give	VBN
cord-003567-h8uq5z8b	16	11	every	every	DT
cord-003567-h8uq5z8b	16	12	year	year	NN
cord-003567-h8uq5z8b	16	13	;	;	:
cord-003567-h8uq5z8b	16	14	however	however	RB
cord-003567-h8uq5z8b	16	15	,	,	,
cord-003567-h8uq5z8b	16	16	even	even	RB
cord-003567-h8uq5z8b	16	17	if	if	IN
cord-003567-h8uq5z8b	16	18	annual	annual	JJ
cord-003567-h8uq5z8b	16	19	vaccination	vaccination	NN
cord-003567-h8uq5z8b	16	20	was	be	VBD
cord-003567-h8uq5z8b	16	21	required	require	VBN
cord-003567-h8uq5z8b	16	22	but	but	CC
cord-003567-h8uq5z8b	16	23	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	16	24	components	component	NNS
cord-003567-h8uq5z8b	16	25	needed	need	VBN
cord-003567-h8uq5z8b	16	26	updating	update	VBG
cord-003567-h8uq5z8b	16	27	only	only	RB
cord-003567-h8uq5z8b	16	28	every	every	DT
cord-003567-h8uq5z8b	16	29	5	5	CD
cord-003567-h8uq5z8b	16	30	-	-	SYM
cord-003567-h8uq5z8b	16	31	10	10	CD
cord-003567-h8uq5z8b	16	32	years	year	NNS
cord-003567-h8uq5z8b	16	33	,	,	,
cord-003567-h8uq5z8b	16	34	it	-PRON-	PRP
cord-003567-h8uq5z8b	16	35	would	would	MD
cord-003567-h8uq5z8b	16	36	still	still	RB
cord-003567-h8uq5z8b	16	37	be	be	VB
cord-003567-h8uq5z8b	16	38	a	a	DT
cord-003567-h8uq5z8b	16	39	significant	significant	JJ
cord-003567-h8uq5z8b	16	40	advance	advance	NN
cord-003567-h8uq5z8b	16	41	over	over	IN
cord-003567-h8uq5z8b	16	42	the	the	DT
cord-003567-h8uq5z8b	16	43	current	current	JJ
cord-003567-h8uq5z8b	16	44	system	system	NN
cord-003567-h8uq5z8b	16	45	.	.	.
cord-003567-h8uq5z8b	17	1	S108	S108	NNP
cord-003567-h8uq5z8b	18	1	•	•	NNP
cord-003567-h8uq5z8b	19	1	jid	jid	NNP
cord-003567-h8uq5z8b	19	2	2019:219	2019:219	CD
cord-003567-h8uq5z8b	20	1	(	(	-LRB-
cord-003567-h8uq5z8b	20	2	Suppl	Suppl	NNP
cord-003567-h8uq5z8b	20	3	1	1	CD
cord-003567-h8uq5z8b	20	4	)	)	-RRB-
cord-003567-h8uq5z8b	21	1	•	•	NNP
cord-003567-h8uq5z8b	22	1	Crank	Crank	NNP
cord-003567-h8uq5z8b	22	2	et	et	NNP
cord-003567-h8uq5z8b	23	1	al	al	NNP
cord-003567-h8uq5z8b	24	1	There	there	EX
cord-003567-h8uq5z8b	24	2	are	be	VBP
cord-003567-h8uq5z8b	24	3	some	some	DT
cord-003567-h8uq5z8b	24	4	clear	clear	JJ
cord-003567-h8uq5z8b	24	5	pathways	pathway	NNS
cord-003567-h8uq5z8b	24	6	to	to	TO
cord-003567-h8uq5z8b	24	7	explore	explore	VB
cord-003567-h8uq5z8b	24	8	and	and	CC
cord-003567-h8uq5z8b	24	9	knowledge	knowledge	NN
cord-003567-h8uq5z8b	24	10	gaps	gap	NNS
cord-003567-h8uq5z8b	24	11	to	to	TO
cord-003567-h8uq5z8b	24	12	fill	fill	VB
cord-003567-h8uq5z8b	24	13	in	in	RP
cord-003567-h8uq5z8b	24	14	the	the	DT
cord-003567-h8uq5z8b	24	15	immediate	immediate	JJ
cord-003567-h8uq5z8b	24	16	future	future	NN
cord-003567-h8uq5z8b	24	17	using	use	VBG
cord-003567-h8uq5z8b	24	18	currently	currently	RB
cord-003567-h8uq5z8b	24	19	available	available	JJ
cord-003567-h8uq5z8b	24	20	technology	technology	NN
cord-003567-h8uq5z8b	24	21	,	,	,
cord-003567-h8uq5z8b	24	22	as	as	IN
cord-003567-h8uq5z8b	24	23	described	describe	VBN
cord-003567-h8uq5z8b	24	24	in	in	IN
cord-003567-h8uq5z8b	24	25	the	the	DT
cord-003567-h8uq5z8b	24	26	accompanying	accompany	VBG
cord-003567-h8uq5z8b	24	27	commentaries	commentary	NNS
cord-003567-h8uq5z8b	24	28	,	,	,
cord-003567-h8uq5z8b	24	29	outlined	outline	VBN
cord-003567-h8uq5z8b	24	30	here	here	RB
cord-003567-h8uq5z8b	24	31	:	:	:
cord-003567-h8uq5z8b	25	1	1	1	LS
cord-003567-h8uq5z8b	25	2	.	.	.
cord-003567-h8uq5z8b	26	1	By	by	IN
cord-003567-h8uq5z8b	26	2	harnessing	harness	VBG
cord-003567-h8uq5z8b	26	3	high	high	JJ
cord-003567-h8uq5z8b	26	4	-	-	HYPH
cord-003567-h8uq5z8b	26	5	throughput	throughput	NN
cord-003567-h8uq5z8b	26	6	sequencing	sequencing	NN
cord-003567-h8uq5z8b	26	7	and	and	CC
cord-003567-h8uq5z8b	26	8	computational	computational	JJ
cord-003567-h8uq5z8b	26	9	biology	biology	NN
cord-003567-h8uq5z8b	26	10	,	,	,
cord-003567-h8uq5z8b	26	11	more	more	RBR
cord-003567-h8uq5z8b	26	12	sophisticated	sophisticated	JJ
cord-003567-h8uq5z8b	26	13	algorithms	algorithm	NNS
cord-003567-h8uq5z8b	26	14	based	base	VBN
cord-003567-h8uq5z8b	26	15	on	on	IN
cord-003567-h8uq5z8b	26	16	sequence	sequence	NN
cord-003567-h8uq5z8b	26	17	analysis	analysis	NN
cord-003567-h8uq5z8b	26	18	,	,	,
cord-003567-h8uq5z8b	26	19	glycan	glycan	NN
cord-003567-h8uq5z8b	26	20	patterns	pattern	NNS
cord-003567-h8uq5z8b	26	21	,	,	,
cord-003567-h8uq5z8b	26	22	and	and	CC
cord-003567-h8uq5z8b	26	23	other	other	JJ
cord-003567-h8uq5z8b	26	24	features	feature	NNS
cord-003567-h8uq5z8b	26	25	that	that	WDT
cord-003567-h8uq5z8b	26	26	may	may	MD
cord-003567-h8uq5z8b	26	27	anticipate	anticipate	VB
cord-003567-h8uq5z8b	26	28	high	high	JJ
cord-003567-h8uq5z8b	26	29	transmissibility	transmissibility	NN
cord-003567-h8uq5z8b	26	30	can	can	MD
cord-003567-h8uq5z8b	26	31	be	be	VB
cord-003567-h8uq5z8b	26	32	developed	develop	VBN
cord-003567-h8uq5z8b	26	33	for	for	IN
cord-003567-h8uq5z8b	26	34	predicting	predict	VBG
cord-003567-h8uq5z8b	26	35	the	the	DT
cord-003567-h8uq5z8b	26	36	next	next	JJ
cord-003567-h8uq5z8b	26	37	dominant	dominant	JJ
cord-003567-h8uq5z8b	26	38	strain	strain	NN
cord-003567-h8uq5z8b	26	39	[	[	-LRB-
cord-003567-h8uq5z8b	26	40	4	4	CD
cord-003567-h8uq5z8b	26	41	]	]	-RRB-
cord-003567-h8uq5z8b	26	42	.	.	.
cord-003567-h8uq5z8b	27	1	The	the	DT
cord-003567-h8uq5z8b	27	2	prudent	prudent	JJ
cord-003567-h8uq5z8b	27	3	study	study	NN
cord-003567-h8uq5z8b	27	4	of	of	IN
cord-003567-h8uq5z8b	27	5	gain	gain	NN
cord-003567-h8uq5z8b	27	6	-	-	HYPH
cord-003567-h8uq5z8b	27	7	of	of	IN
cord-003567-h8uq5z8b	27	8	-	-	HYPH
cord-003567-h8uq5z8b	27	9	function	function	NN
cord-003567-h8uq5z8b	27	10	mutations	mutation	NNS
cord-003567-h8uq5z8b	27	11	would	would	MD
cord-003567-h8uq5z8b	27	12	allow	allow	VB
cord-003567-h8uq5z8b	27	13	scientists	scientist	NNS
cord-003567-h8uq5z8b	27	14	to	to	TO
cord-003567-h8uq5z8b	27	15	learn	learn	VB
cord-003567-h8uq5z8b	27	16	more	more	JJR
cord-003567-h8uq5z8b	27	17	about	about	IN
cord-003567-h8uq5z8b	27	18	what	what	WP
cord-003567-h8uq5z8b	27	19	molecular	molecular	JJ
cord-003567-h8uq5z8b	27	20	signatures	signature	NNS
cord-003567-h8uq5z8b	27	21	to	to	TO
cord-003567-h8uq5z8b	27	22	look	look	VB
cord-003567-h8uq5z8b	27	23	for	for	IN
cord-003567-h8uq5z8b	27	24	.	.	.
cord-003567-h8uq5z8b	28	1	2	2	LS
cord-003567-h8uq5z8b	28	2	.	.	.
cord-003567-h8uq5z8b	29	1	Improving	improve	VBG
cord-003567-h8uq5z8b	29	2	strain	strain	NN
cord-003567-h8uq5z8b	29	3	selection	selection	NN
cord-003567-h8uq5z8b	29	4	for	for	IN
cord-003567-h8uq5z8b	29	5	seasonal	seasonal	JJ
cord-003567-h8uq5z8b	29	6	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	29	7	would	would	MD
cord-003567-h8uq5z8b	29	8	increase	increase	VB
cord-003567-h8uq5z8b	29	9	the	the	DT
cord-003567-h8uq5z8b	29	10	likelihood	likelihood	NN
cord-003567-h8uq5z8b	29	11	of	of	IN
cord-003567-h8uq5z8b	29	12	an	an	DT
cord-003567-h8uq5z8b	29	13	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	29	14	match	match	NN
cord-003567-h8uq5z8b	29	15	between	between	IN
cord-003567-h8uq5z8b	29	16	the	the	DT
cord-003567-h8uq5z8b	29	17	vaccine	vaccine	NN
cord-003567-h8uq5z8b	29	18	and	and	CC
cord-003567-h8uq5z8b	29	19	dominant	dominant	JJ
cord-003567-h8uq5z8b	29	20	circulating	circulate	VBG
cord-003567-h8uq5z8b	29	21	strains	strain	NNS
cord-003567-h8uq5z8b	29	22	and	and	CC
cord-003567-h8uq5z8b	29	23	thereby	thereby	RB
cord-003567-h8uq5z8b	29	24	improve	improve	VB
cord-003567-h8uq5z8b	29	25	the	the	DT
cord-003567-h8uq5z8b	29	26	utility	utility	NN
cord-003567-h8uq5z8b	29	27	of	of	IN
cord-003567-h8uq5z8b	29	28	current	current	JJ
cord-003567-h8uq5z8b	29	29	vaccine	vaccine	NN
cord-003567-h8uq5z8b	29	30	technology	technology	NN
cord-003567-h8uq5z8b	29	31	[	[	-LRB-
cord-003567-h8uq5z8b	29	32	2	2	CD
cord-003567-h8uq5z8b	29	33	]	]	-RRB-
cord-003567-h8uq5z8b	29	34	.	.	.
cord-003567-h8uq5z8b	30	1	The	the	DT
cord-003567-h8uq5z8b	30	2	current	current	JJ
cord-003567-h8uq5z8b	30	3	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	30	4	could	could	MD
cord-003567-h8uq5z8b	30	5	be	be	VB
cord-003567-h8uq5z8b	30	6	further	further	RB
cord-003567-h8uq5z8b	30	7	improved	improve	VBN
cord-003567-h8uq5z8b	30	8	by	by	IN
cord-003567-h8uq5z8b	30	9	better	well	JJR
cord-003567-h8uq5z8b	30	10	standardization	standardization	NN
cord-003567-h8uq5z8b	30	11	of	of	IN
cord-003567-h8uq5z8b	30	12	the	the	DT
cord-003567-h8uq5z8b	30	13	neuraminidase	neuraminidase	NN
cord-003567-h8uq5z8b	30	14	content	content	NN
cord-003567-h8uq5z8b	30	15	,	,	,
cord-003567-h8uq5z8b	30	16	adjustment	adjustment	NN
cord-003567-h8uq5z8b	30	17	of	of	IN
cord-003567-h8uq5z8b	30	18	antigen	antigen	NN
cord-003567-h8uq5z8b	30	19	doses	dose	NNS
cord-003567-h8uq5z8b	30	20	,	,	,
cord-003567-h8uq5z8b	30	21	addition	addition	NN
cord-003567-h8uq5z8b	30	22	of	of	IN
cord-003567-h8uq5z8b	30	23	improved	improved	JJ
cord-003567-h8uq5z8b	30	24	adjuvants	adjuvant	NNS
cord-003567-h8uq5z8b	30	25	,	,	,
cord-003567-h8uq5z8b	30	26	and	and	CC
cord-003567-h8uq5z8b	30	27	production	production	NN
cord-003567-h8uq5z8b	30	28	in	in	IN
cord-003567-h8uq5z8b	30	29	cell	cell	NN
cord-003567-h8uq5z8b	30	30	substrates	substrate	NNS
cord-003567-h8uq5z8b	30	31	that	that	WDT
cord-003567-h8uq5z8b	30	32	minimize	minimize	VBP
cord-003567-h8uq5z8b	30	33	the	the	DT
cord-003567-h8uq5z8b	30	34	likelihood	likelihood	NN
cord-003567-h8uq5z8b	30	35	of	of	IN
cord-003567-h8uq5z8b	30	36	viral	viral	JJ
cord-003567-h8uq5z8b	30	37	adaptations	adaptation	NNS
cord-003567-h8uq5z8b	30	38	and	and	CC
cord-003567-h8uq5z8b	30	39	changes	change	NNS
cord-003567-h8uq5z8b	30	40	in	in	IN
cord-003567-h8uq5z8b	30	41	protein	protein	NN
cord-003567-h8uq5z8b	30	42	sequences	sequence	NNS
cord-003567-h8uq5z8b	30	43	[	[	-LRB-
cord-003567-h8uq5z8b	30	44	2	2	CD
cord-003567-h8uq5z8b	30	45	]	]	-RRB-
cord-003567-h8uq5z8b	30	46	.	.	.
cord-003567-h8uq5z8b	31	1	3	3	LS
cord-003567-h8uq5z8b	31	2	.	.	.
cord-003567-h8uq5z8b	32	1	Precisely	precisely	RB
cord-003567-h8uq5z8b	32	2	defining	define	VBG
cord-003567-h8uq5z8b	32	3	the	the	DT
cord-003567-h8uq5z8b	32	4	B	b	NN
cord-003567-h8uq5z8b	32	5	-	-	HYPH
cord-003567-h8uq5z8b	32	6	cell	cell	NN
cord-003567-h8uq5z8b	32	7	repertoire	repertoire	NN
cord-003567-h8uq5z8b	32	8	and	and	CC
cord-003567-h8uq5z8b	32	9	epitope	epitope	NN
cord-003567-h8uq5z8b	32	10	-	-	HYPH
cord-003567-h8uq5z8b	32	11	specific	specific	JJ
cord-003567-h8uq5z8b	32	12	phenotypes	phenotype	NNS
cord-003567-h8uq5z8b	32	13	involved	involve	VBN
cord-003567-h8uq5z8b	32	14	in	in	IN
cord-003567-h8uq5z8b	32	15	the	the	DT
cord-003567-h8uq5z8b	32	16	response	response	NN
cord-003567-h8uq5z8b	32	17	to	to	IN
cord-003567-h8uq5z8b	32	18	influenza	influenza	NN
cord-003567-h8uq5z8b	32	19	infection	infection	NN
cord-003567-h8uq5z8b	32	20	and	and	CC
cord-003567-h8uq5z8b	32	21	vaccination	vaccination	NN
cord-003567-h8uq5z8b	32	22	would	would	MD
cord-003567-h8uq5z8b	32	23	provide	provide	VB
cord-003567-h8uq5z8b	32	24	insight	insight	NN
cord-003567-h8uq5z8b	32	25	into	into	IN
cord-003567-h8uq5z8b	32	26	the	the	DT
cord-003567-h8uq5z8b	32	27	problem	problem	NN
cord-003567-h8uq5z8b	32	28	of	of	IN
cord-003567-h8uq5z8b	32	29	"	"	``
cord-003567-h8uq5z8b	32	30	original	original	JJ
cord-003567-h8uq5z8b	32	31	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	32	32	sin	sin	NN
cord-003567-h8uq5z8b	32	33	"	"	''
cord-003567-h8uq5z8b	32	34	described	describe	VBN
cord-003567-h8uq5z8b	32	35	by	by	IN
cord-003567-h8uq5z8b	32	36	Thomas	Thomas	NNP
cord-003567-h8uq5z8b	32	37	Francis	Francis	NNP
cord-003567-h8uq5z8b	32	38	in	in	IN
cord-003567-h8uq5z8b	32	39	1960	1960	CD
cord-003567-h8uq5z8b	32	40	and	and	CC
cord-003567-h8uq5z8b	32	41	the	the	DT
cord-003567-h8uq5z8b	32	42	related	related	JJ
cord-003567-h8uq5z8b	32	43	phenomenon	phenomenon	NN
cord-003567-h8uq5z8b	32	44	of	of	IN
cord-003567-h8uq5z8b	32	45	immunodominance	immunodominance	NN
cord-003567-h8uq5z8b	32	46	[	[	-LRB-
cord-003567-h8uq5z8b	32	47	22	22	CD
cord-003567-h8uq5z8b	32	48	]	]	-RRB-
cord-003567-h8uq5z8b	32	49	.	.	.
cord-003567-h8uq5z8b	33	1	Prior	prior	JJ
cord-003567-h8uq5z8b	33	2	influenza	influenza	NN
cord-003567-h8uq5z8b	33	3	immunity	immunity	NN
cord-003567-h8uq5z8b	33	4	and	and	CC
cord-003567-h8uq5z8b	33	5	poorly	poorly	RB
cord-003567-h8uq5z8b	33	6	understood	understand	VBD
cord-003567-h8uq5z8b	33	7	antigenicity	antigenicity	NN
cord-003567-h8uq5z8b	33	8	patterns	pattern	NNS
cord-003567-h8uq5z8b	33	9	make	make	VBP
cord-003567-h8uq5z8b	33	10	it	-PRON-	PRP
cord-003567-h8uq5z8b	33	11	difficult	difficult	JJ
cord-003567-h8uq5z8b	33	12	to	to	TO
cord-003567-h8uq5z8b	33	13	reshape	reshape	VB
cord-003567-h8uq5z8b	33	14	and	and	CC
cord-003567-h8uq5z8b	33	15	broaden	broaden	VB
cord-003567-h8uq5z8b	33	16	the	the	DT
cord-003567-h8uq5z8b	33	17	antibody	antibody	NN
cord-003567-h8uq5z8b	33	18	response	response	NN
cord-003567-h8uq5z8b	33	19	using	use	VBG
cord-003567-h8uq5z8b	33	20	current	current	JJ
cord-003567-h8uq5z8b	33	21	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	33	22	[	[	-LRB-
cord-003567-h8uq5z8b	33	23	7	7	CD
cord-003567-h8uq5z8b	33	24	]	]	-RRB-
cord-003567-h8uq5z8b	33	25	.	.	.
cord-003567-h8uq5z8b	34	1	Defining	define	VBG
cord-003567-h8uq5z8b	34	2	all	all	PDT
cord-003567-h8uq5z8b	34	3	the	the	DT
cord-003567-h8uq5z8b	34	4	ways	way	NNS
cord-003567-h8uq5z8b	34	5	antibody	antibody	NN
cord-003567-h8uq5z8b	34	6	can	can	MD
cord-003567-h8uq5z8b	34	7	bind	bind	VB
cord-003567-h8uq5z8b	34	8	and	and	CC
cord-003567-h8uq5z8b	34	9	neutralize	neutralize	VB
cord-003567-h8uq5z8b	34	10	influenza	influenza	NN
cord-003567-h8uq5z8b	34	11	structurally	structurally	RB
cord-003567-h8uq5z8b	34	12	and	and	CC
cord-003567-h8uq5z8b	34	13	establishing	establish	VBG
cord-003567-h8uq5z8b	34	14	a	a	DT
cord-003567-h8uq5z8b	34	15	new	new	JJ
cord-003567-h8uq5z8b	34	16	nomenclature	nomenclature	NN
cord-003567-h8uq5z8b	34	17	for	for	IN
cord-003567-h8uq5z8b	34	18	describing	describe	VBG
cord-003567-h8uq5z8b	34	19	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	34	20	sites	site	NNS
cord-003567-h8uq5z8b	34	21	across	across	IN
cord-003567-h8uq5z8b	34	22	both	both	DT
cord-003567-h8uq5z8b	34	23	influenza	influenza	NN
cord-003567-h8uq5z8b	34	24	A	a	DT
cord-003567-h8uq5z8b	34	25	groups	group	NNS
cord-003567-h8uq5z8b	34	26	as	as	RB
cord-003567-h8uq5z8b	34	27	well	well	RB
cord-003567-h8uq5z8b	34	28	as	as	IN
cord-003567-h8uq5z8b	34	29	influenza	influenza	NN
cord-003567-h8uq5z8b	34	30	B	B	NNP
cord-003567-h8uq5z8b	34	31	would	would	MD
cord-003567-h8uq5z8b	34	32	reduce	reduce	VB
cord-003567-h8uq5z8b	34	33	confusion	confusion	NN
cord-003567-h8uq5z8b	34	34	and	and	CC
cord-003567-h8uq5z8b	34	35	improve	improve	VB
cord-003567-h8uq5z8b	34	36	communication	communication	NN
cord-003567-h8uq5z8b	34	37	between	between	IN
cord-003567-h8uq5z8b	34	38	scientists	scientist	NNS
cord-003567-h8uq5z8b	34	39	[	[	-LRB-
cord-003567-h8uq5z8b	34	40	5	5	CD
cord-003567-h8uq5z8b	34	41	]	]	-RRB-
cord-003567-h8uq5z8b	34	42	.	.	.
cord-003567-h8uq5z8b	35	1	In	in	IN
cord-003567-h8uq5z8b	35	2	addition	addition	NN
cord-003567-h8uq5z8b	35	3	,	,	,
cord-003567-h8uq5z8b	35	4	learning	learning	NN
cord-003567-h8uq5z8b	35	5	which	which	WDT
cord-003567-h8uq5z8b	35	6	features	feature	VBZ
cord-003567-h8uq5z8b	35	7	of	of	IN
cord-003567-h8uq5z8b	35	8	vaccine	vaccine	NN
cord-003567-h8uq5z8b	35	9	-	-	HYPH
cord-003567-h8uq5z8b	35	10	induced	induce	VBN
cord-003567-h8uq5z8b	35	11	local	local	JJ
cord-003567-h8uq5z8b	35	12	or	or	CC
cord-003567-h8uq5z8b	35	13	systemic	systemic	JJ
cord-003567-h8uq5z8b	35	14	immune	immune	JJ
cord-003567-h8uq5z8b	35	15	responses	response	NNS
cord-003567-h8uq5z8b	35	16	result	result	VBP
cord-003567-h8uq5z8b	35	17	in	in	IN
cord-003567-h8uq5z8b	35	18	sustained	sustained	JJ
cord-003567-h8uq5z8b	35	19	serum	serum	NN
cord-003567-h8uq5z8b	35	20	antibody	antibody	NN
cord-003567-h8uq5z8b	35	21	responses	response	NNS
cord-003567-h8uq5z8b	35	22	may	may	MD
cord-003567-h8uq5z8b	35	23	inform	inform	VB
cord-003567-h8uq5z8b	35	24	vaccine	vaccine	NN
cord-003567-h8uq5z8b	35	25	formulation	formulation	NN
cord-003567-h8uq5z8b	35	26	and	and	CC
cord-003567-h8uq5z8b	35	27	delivery	delivery	NN
cord-003567-h8uq5z8b	35	28	approaches	approach	NNS
cord-003567-h8uq5z8b	35	29	.	.	.
cord-003567-h8uq5z8b	36	1	4	4	LS
cord-003567-h8uq5z8b	36	2	.	.	.
cord-003567-h8uq5z8b	37	1	Understanding	understand	VBG
cord-003567-h8uq5z8b	37	2	more	more	RBR
cord-003567-h8uq5z8b	37	3	precisely	precisely	RB
cord-003567-h8uq5z8b	37	4	the	the	DT
cord-003567-h8uq5z8b	37	5	B	b	NN
cord-003567-h8uq5z8b	37	6	-	-	HYPH
cord-003567-h8uq5z8b	37	7	cell	cell	NN
cord-003567-h8uq5z8b	37	8	and	and	CC
cord-003567-h8uq5z8b	37	9	antibody	antibody	NN
cord-003567-h8uq5z8b	37	10	responses	response	NNS
cord-003567-h8uq5z8b	37	11	would	would	MD
cord-003567-h8uq5z8b	37	12	allow	allow	VB
cord-003567-h8uq5z8b	37	13	the	the	DT
cord-003567-h8uq5z8b	37	14	application	application	NN
cord-003567-h8uq5z8b	37	15	of	of	IN
cord-003567-h8uq5z8b	37	16	protein	protein	NN
cord-003567-h8uq5z8b	37	17	engineering	engineering	NN
cord-003567-h8uq5z8b	37	18	for	for	IN
cord-003567-h8uq5z8b	37	19	antigen	antigen	NN
cord-003567-h8uq5z8b	37	20	design	design	NN
cord-003567-h8uq5z8b	37	21	and	and	CC
cord-003567-h8uq5z8b	37	22	display	display	NN
cord-003567-h8uq5z8b	37	23	using	use	VBG
cord-003567-h8uq5z8b	37	24	molecular	molecular	JJ
cord-003567-h8uq5z8b	37	25	targets	target	NNS
cord-003567-h8uq5z8b	37	26	and	and	CC
cord-003567-h8uq5z8b	37	27	antibody	antibody	NN
cord-003567-h8uq5z8b	37	28	lineage	lineage	NN
cord-003567-h8uq5z8b	37	29	end	end	VBP
cord-003567-h8uq5z8b	37	30	points	point	NNS
cord-003567-h8uq5z8b	37	31	to	to	TO
cord-003567-h8uq5z8b	37	32	guide	guide	VB
cord-003567-h8uq5z8b	37	33	iterative	iterative	JJ
cord-003567-h8uq5z8b	37	34	design	design	NN
cord-003567-h8uq5z8b	37	35	modifications	modification	NNS
cord-003567-h8uq5z8b	37	36	[	[	-LRB-
cord-003567-h8uq5z8b	37	37	14	14	CD
cord-003567-h8uq5z8b	37	38	]	]	-RRB-
cord-003567-h8uq5z8b	37	39	.	.	.
cord-003567-h8uq5z8b	38	1	5	5	LS
cord-003567-h8uq5z8b	38	2	.	.	.
cord-003567-h8uq5z8b	39	1	The	the	DT
cord-003567-h8uq5z8b	39	2	role	role	NN
cord-003567-h8uq5z8b	39	3	of	of	IN
cord-003567-h8uq5z8b	39	4	CD4	CD4	NNP
cord-003567-h8uq5z8b	39	5	+	+	CC
cord-003567-h8uq5z8b	39	6	T	t	NN
cord-003567-h8uq5z8b	39	7	cells	cell	NNS
cord-003567-h8uq5z8b	39	8	in	in	IN
cord-003567-h8uq5z8b	39	9	determining	determine	VBG
cord-003567-h8uq5z8b	39	10	the	the	DT
cord-003567-h8uq5z8b	39	11	efficacy	efficacy	NN
cord-003567-h8uq5z8b	39	12	of	of	IN
cord-003567-h8uq5z8b	39	13	a	a	DT
cord-003567-h8uq5z8b	39	14	B	b	NN
cord-003567-h8uq5z8b	39	15	-	-	HYPH
cord-003567-h8uq5z8b	39	16	cell	cell	NN
cord-003567-h8uq5z8b	39	17	response	response	NN
cord-003567-h8uq5z8b	39	18	is	be	VBZ
cord-003567-h8uq5z8b	39	19	an	an	DT
cord-003567-h8uq5z8b	39	20	area	area	NN
cord-003567-h8uq5z8b	39	21	of	of	IN
cord-003567-h8uq5z8b	39	22	active	active	JJ
cord-003567-h8uq5z8b	39	23	investigation	investigation	NN
cord-003567-h8uq5z8b	39	24	;	;	:
cord-003567-h8uq5z8b	39	25	however	however	RB
cord-003567-h8uq5z8b	39	26	,	,	,
cord-003567-h8uq5z8b	39	27	more	more	JJR
cord-003567-h8uq5z8b	39	28	work	work	NN
cord-003567-h8uq5z8b	39	29	in	in	IN
cord-003567-h8uq5z8b	39	30	this	this	DT
cord-003567-h8uq5z8b	39	31	area	area	NN
cord-003567-h8uq5z8b	39	32	may	may	MD
cord-003567-h8uq5z8b	39	33	be	be	VB
cord-003567-h8uq5z8b	39	34	required	require	VBN
cord-003567-h8uq5z8b	39	35	to	to	TO
cord-003567-h8uq5z8b	39	36	solve	solve	VB
cord-003567-h8uq5z8b	39	37	the	the	DT
cord-003567-h8uq5z8b	39	38	problem	problem	NN
cord-003567-h8uq5z8b	39	39	of	of	IN
cord-003567-h8uq5z8b	39	40	durability	durability	NN
cord-003567-h8uq5z8b	39	41	and	and	CC
cord-003567-h8uq5z8b	39	42	maintenance	maintenance	NN
cord-003567-h8uq5z8b	39	43	of	of	IN
cord-003567-h8uq5z8b	39	44	antibody	antibody	NN
cord-003567-h8uq5z8b	39	45	responses	response	NNS
cord-003567-h8uq5z8b	39	46	[	[	-LRB-
cord-003567-h8uq5z8b	39	47	6	6	CD
cord-003567-h8uq5z8b	39	48	]	]	-RRB-
cord-003567-h8uq5z8b	39	49	.	.	.
cord-003567-h8uq5z8b	40	1	6	6	LS
cord-003567-h8uq5z8b	40	2	.	.	.
cord-003567-h8uq5z8b	41	1	The	the	DT
cord-003567-h8uq5z8b	41	2	direct	direct	JJ
cord-003567-h8uq5z8b	41	3	role	role	NN
cord-003567-h8uq5z8b	41	4	of	of	IN
cord-003567-h8uq5z8b	41	5	CD4	CD4	NNP
cord-003567-h8uq5z8b	41	6	+	+	CC
cord-003567-h8uq5z8b	41	7	or	or	CC
cord-003567-h8uq5z8b	41	8	CD8	CD8	NNP
cord-003567-h8uq5z8b	41	9	+	+	CC
cord-003567-h8uq5z8b	41	10	T	t	NN
cord-003567-h8uq5z8b	41	11	-	-	HYPH
cord-003567-h8uq5z8b	41	12	cell	cell	NN
cord-003567-h8uq5z8b	41	13	effector	effector	NN
cord-003567-h8uq5z8b	41	14	functions	function	NNS
cord-003567-h8uq5z8b	41	15	and	and	CC
cord-003567-h8uq5z8b	41	16	whether	whether	IN
cord-003567-h8uq5z8b	41	17	those	those	DT
cord-003567-h8uq5z8b	41	18	cells	cell	NNS
cord-003567-h8uq5z8b	41	19	require	require	VBP
cord-003567-h8uq5z8b	41	20	localization	localization	NN
cord-003567-h8uq5z8b	41	21	in	in	IN
cord-003567-h8uq5z8b	41	22	mucosal	mucosal	JJ
cord-003567-h8uq5z8b	41	23	tissue	tissue	NN
cord-003567-h8uq5z8b	41	24	or	or	CC
cord-003567-h8uq5z8b	41	25	lymph	lymph	NN
cord-003567-h8uq5z8b	41	26	nodes	node	NNS
cord-003567-h8uq5z8b	41	27	to	to	TO
cord-003567-h8uq5z8b	41	28	effectively	effectively	RB
cord-003567-h8uq5z8b	41	29	protect	protect	VB
cord-003567-h8uq5z8b	41	30	against	against	IN
cord-003567-h8uq5z8b	41	31	respiratory	respiratory	JJ
cord-003567-h8uq5z8b	41	32	viral	viral	JJ
cord-003567-h8uq5z8b	41	33	pathogens	pathogen	NNS
cord-003567-h8uq5z8b	41	34	are	be	VBP
cord-003567-h8uq5z8b	41	35	poorly	poorly	RB
cord-003567-h8uq5z8b	41	36	understood	understand	VBN
cord-003567-h8uq5z8b	41	37	.	.	.
cord-003567-h8uq5z8b	42	1	Optimizing	optimize	VBG
cord-003567-h8uq5z8b	42	2	vaccine	vaccine	NN
cord-003567-h8uq5z8b	42	3	formulation	formulation	NN
cord-003567-h8uq5z8b	42	4	and	and	CC
cord-003567-h8uq5z8b	42	5	delivery	delivery	NN
cord-003567-h8uq5z8b	42	6	route	route	NN
cord-003567-h8uq5z8b	42	7	and	and	CC
cord-003567-h8uq5z8b	42	8	modality	modality	NN
cord-003567-h8uq5z8b	42	9	is	be	VBZ
cord-003567-h8uq5z8b	42	10	dependent	dependent	JJ
cord-003567-h8uq5z8b	42	11	on	on	IN
cord-003567-h8uq5z8b	42	12	acquiring	acquire	VBG
cord-003567-h8uq5z8b	42	13	this	this	DT
cord-003567-h8uq5z8b	42	14	type	type	NN
cord-003567-h8uq5z8b	42	15	of	of	IN
cord-003567-h8uq5z8b	42	16	knowledge	knowledge	NN
cord-003567-h8uq5z8b	42	17	[	[	-LRB-
cord-003567-h8uq5z8b	42	18	6	6	CD
cord-003567-h8uq5z8b	42	19	]	]	-RRB-
cord-003567-h8uq5z8b	42	20	.	.	.
cord-003567-h8uq5z8b	43	1	7	7	CD
cord-003567-h8uq5z8b	43	2	.	.	.
cord-003567-h8uq5z8b	44	1	Defining	define	VBG
cord-003567-h8uq5z8b	44	2	the	the	DT
cord-003567-h8uq5z8b	44	3	importance	importance	NN
cord-003567-h8uq5z8b	44	4	of	of	IN
cord-003567-h8uq5z8b	44	5	including	include	VBG
cord-003567-h8uq5z8b	44	6	specific	specific	JJ
cord-003567-h8uq5z8b	44	7	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	44	8	targets	target	NNS
cord-003567-h8uq5z8b	44	9	,	,	,
cord-003567-h8uq5z8b	44	10	such	such	JJ
cord-003567-h8uq5z8b	44	11	as	as	IN
cord-003567-h8uq5z8b	44	12	the	the	DT
cord-003567-h8uq5z8b	44	13	head	head	NN
cord-003567-h8uq5z8b	44	14	or	or	CC
cord-003567-h8uq5z8b	44	15	stem	stem	NN
cord-003567-h8uq5z8b	44	16	domains	domain	NNS
cord-003567-h8uq5z8b	44	17	of	of	IN
cord-003567-h8uq5z8b	44	18	hemagglutinin	hemagglutinin	NN
cord-003567-h8uq5z8b	44	19	,	,	,
cord-003567-h8uq5z8b	44	20	neuraminidase	neuraminidase	NN
cord-003567-h8uq5z8b	44	21	,	,	,
cord-003567-h8uq5z8b	44	22	or	or	CC
cord-003567-h8uq5z8b	44	23	the	the	DT
cord-003567-h8uq5z8b	44	24	M2	M2	NNP
cord-003567-h8uq5z8b	44	25	ectodomain	ectodomain	NN
cord-003567-h8uq5z8b	44	26	in	in	IN
cord-003567-h8uq5z8b	44	27	universal	universal	JJ
cord-003567-h8uq5z8b	44	28	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	44	29	,	,	,
cord-003567-h8uq5z8b	44	30	and	and	CC
cord-003567-h8uq5z8b	44	31	determining	determine	VBG
cord-003567-h8uq5z8b	44	32	whether	whether	IN
cord-003567-h8uq5z8b	44	33	they	-PRON-	PRP
cord-003567-h8uq5z8b	44	34	are	be	VBP
cord-003567-h8uq5z8b	44	35	more	more	RBR
cord-003567-h8uq5z8b	44	36	effective	effective	JJ
cord-003567-h8uq5z8b	44	37	when	when	WRB
cord-003567-h8uq5z8b	44	38	used	use	VBN
cord-003567-h8uq5z8b	44	39	in	in	IN
cord-003567-h8uq5z8b	44	40	combination	combination	NN
cord-003567-h8uq5z8b	44	41	or	or	CC
cord-003567-h8uq5z8b	44	42	alone	alone	RB
cord-003567-h8uq5z8b	44	43	could	could	MD
cord-003567-h8uq5z8b	44	44	be	be	VB
cord-003567-h8uq5z8b	44	45	accomplished	accomplish	VBN
cord-003567-h8uq5z8b	44	46	through	through	IN
cord-003567-h8uq5z8b	44	47	both	both	DT
cord-003567-h8uq5z8b	44	48	vaccine	vaccine	NN
cord-003567-h8uq5z8b	44	49	protection	protection	NN
cord-003567-h8uq5z8b	44	50	and	and	CC
cord-003567-h8uq5z8b	44	51	natural	natural	JJ
cord-003567-h8uq5z8b	44	52	history	history	NN
cord-003567-h8uq5z8b	44	53	studies	study	NNS
cord-003567-h8uq5z8b	44	54	that	that	WDT
cord-003567-h8uq5z8b	44	55	provide	provide	VBP
cord-003567-h8uq5z8b	44	56	a	a	DT
cord-003567-h8uq5z8b	44	57	better	well	JJR
cord-003567-h8uq5z8b	44	58	understanding	understanding	NN
cord-003567-h8uq5z8b	44	59	of	of	IN
cord-003567-h8uq5z8b	44	60	protective	protective	JJ
cord-003567-h8uq5z8b	44	61	immunity	immunity	NN
cord-003567-h8uq5z8b	44	62	[	[	-LRB-
cord-003567-h8uq5z8b	44	63	9	9	CD
cord-003567-h8uq5z8b	44	64	]	]	-RRB-
cord-003567-h8uq5z8b	44	65	[	[	-LRB-
cord-003567-h8uq5z8b	44	66	10	10	CD
cord-003567-h8uq5z8b	44	67	]	]	-RRB-
cord-003567-h8uq5z8b	44	68	[	[	-LRB-
cord-003567-h8uq5z8b	44	69	11	11	CD
cord-003567-h8uq5z8b	44	70	]	]	-RRB-
cord-003567-h8uq5z8b	44	71	[	[	-LRB-
cord-003567-h8uq5z8b	44	72	12	12	CD
cord-003567-h8uq5z8b	44	73	]	]	-RRB-
cord-003567-h8uq5z8b	44	74	.	.	.
cord-003567-h8uq5z8b	45	1	8	8	CD
cord-003567-h8uq5z8b	45	2	.	.	.
cord-003567-h8uq5z8b	46	1	Understanding	understand	VBG
cord-003567-h8uq5z8b	46	2	the	the	DT
cord-003567-h8uq5z8b	46	3	mechanistic	mechanistic	JJ
cord-003567-h8uq5z8b	46	4	correlates	correlate	NNS
cord-003567-h8uq5z8b	46	5	of	of	IN
cord-003567-h8uq5z8b	46	6	immunity	immunity	NN
cord-003567-h8uq5z8b	46	7	generated	generate	VBN
cord-003567-h8uq5z8b	46	8	by	by	IN
cord-003567-h8uq5z8b	46	9	immunization	immunization	NN
cord-003567-h8uq5z8b	46	10	with	with	IN
cord-003567-h8uq5z8b	46	11	live	live	JJ
cord-003567-h8uq5z8b	46	12	attenuated	attenuated	JJ
cord-003567-h8uq5z8b	46	13	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	46	14	may	may	MD
cord-003567-h8uq5z8b	46	15	reveal	reveal	VB
cord-003567-h8uq5z8b	46	16	the	the	DT
cord-003567-h8uq5z8b	46	17	importance	importance	NN
cord-003567-h8uq5z8b	46	18	of	of	IN
cord-003567-h8uq5z8b	46	19	secretory	secretory	JJ
cord-003567-h8uq5z8b	46	20	immunoglobulin	immunoglobulin	NN
cord-003567-h8uq5z8b	46	21	A	a	NN
cord-003567-h8uq5z8b	46	22	and	and	CC
cord-003567-h8uq5z8b	46	23	intraepithelial	intraepithelial	JJ
cord-003567-h8uq5z8b	46	24	T	t	NN
cord-003567-h8uq5z8b	46	25	cells	cell	NNS
cord-003567-h8uq5z8b	46	26	that	that	WDT
cord-003567-h8uq5z8b	46	27	require	require	VBP
cord-003567-h8uq5z8b	46	28	induction	induction	NN
cord-003567-h8uq5z8b	46	29	of	of	IN
cord-003567-h8uq5z8b	46	30	immunity	immunity	NN
cord-003567-h8uq5z8b	46	31	to	to	TO
cord-003567-h8uq5z8b	46	32	occur	occur	VB
cord-003567-h8uq5z8b	46	33	at	at	IN
cord-003567-h8uq5z8b	46	34	the	the	DT
cord-003567-h8uq5z8b	46	35	mucosal	mucosal	NN
cord-003567-h8uq5z8b	46	36	surface	surface	NN
cord-003567-h8uq5z8b	46	37	[	[	-LRB-
cord-003567-h8uq5z8b	46	38	13	13	CD
cord-003567-h8uq5z8b	46	39	]	]	-RRB-
cord-003567-h8uq5z8b	46	40	.	.	.
cord-003567-h8uq5z8b	47	1	9	9	LS
cord-003567-h8uq5z8b	47	2	.	.	.
cord-003567-h8uq5z8b	48	1	Defining	define	VBG
cord-003567-h8uq5z8b	48	2	both	both	CC
cord-003567-h8uq5z8b	48	3	the	the	DT
cord-003567-h8uq5z8b	48	4	virological	virological	NN
cord-003567-h8uq5z8b	48	5	and	and	CC
cord-003567-h8uq5z8b	48	6	host	host	NN
cord-003567-h8uq5z8b	48	7	immune	immune	JJ
cord-003567-h8uq5z8b	48	8	response	response	NN
cord-003567-h8uq5z8b	48	9	patterns	pattern	NNS
cord-003567-h8uq5z8b	48	10	associated	associate	VBN
cord-003567-h8uq5z8b	48	11	with	with	IN
cord-003567-h8uq5z8b	48	12	transmissibility	transmissibility	NN
cord-003567-h8uq5z8b	48	13	would	would	MD
cord-003567-h8uq5z8b	48	14	allow	allow	VB
cord-003567-h8uq5z8b	48	15	better	well	JJR
cord-003567-h8uq5z8b	48	16	modeling	modeling	NN
cord-003567-h8uq5z8b	48	17	of	of	IN
cord-003567-h8uq5z8b	48	18	population	population	NN
cord-003567-h8uq5z8b	48	19	dynamics	dynamic	NNS
cord-003567-h8uq5z8b	48	20	and	and	CC
cord-003567-h8uq5z8b	48	21	factors	factor	NNS
cord-003567-h8uq5z8b	48	22	that	that	WDT
cord-003567-h8uq5z8b	48	23	could	could	MD
cord-003567-h8uq5z8b	48	24	best	well	RBS
cord-003567-h8uq5z8b	48	25	interrupt	interrupt	VB
cord-003567-h8uq5z8b	48	26	transmission	transmission	NN
cord-003567-h8uq5z8b	48	27	cycles	cycle	NNS
cord-003567-h8uq5z8b	48	28	[	[	-LRB-
cord-003567-h8uq5z8b	48	29	8	8	CD
cord-003567-h8uq5z8b	48	30	]	]	-RRB-
cord-003567-h8uq5z8b	48	31	.	.	.
cord-003567-h8uq5z8b	49	1	This	this	DT
cord-003567-h8uq5z8b	49	2	could	could	MD
cord-003567-h8uq5z8b	49	3	be	be	VB
cord-003567-h8uq5z8b	49	4	particularly	particularly	RB
cord-003567-h8uq5z8b	49	5	important	important	JJ
cord-003567-h8uq5z8b	49	6	for	for	IN
cord-003567-h8uq5z8b	49	7	identifying	identify	VBG
cord-003567-h8uq5z8b	49	8	distinct	distinct	JJ
cord-003567-h8uq5z8b	49	9	vaccination	vaccination	NN
cord-003567-h8uq5z8b	49	10	strategies	strategy	NNS
cord-003567-h8uq5z8b	49	11	for	for	IN
cord-003567-h8uq5z8b	49	12	different	different	JJ
cord-003567-h8uq5z8b	49	13	target	target	NN
cord-003567-h8uq5z8b	49	14	populations	population	NNS
cord-003567-h8uq5z8b	49	15	,	,	,
cord-003567-h8uq5z8b	49	16	including	include	VBG
cord-003567-h8uq5z8b	49	17	in	in	IN
cord-003567-h8uq5z8b	49	18	societal	societal	JJ
cord-003567-h8uq5z8b	49	19	settings	setting	NNS
cord-003567-h8uq5z8b	49	20	in	in	IN
cord-003567-h8uq5z8b	49	21	which	which	WDT
cord-003567-h8uq5z8b	49	22	transmission	transmission	NN
cord-003567-h8uq5z8b	49	23	dynamics	dynamic	NNS
cord-003567-h8uq5z8b	49	24	and	and	CC
cord-003567-h8uq5z8b	49	25	target	target	NN
cord-003567-h8uq5z8b	49	26	populations	population	NNS
cord-003567-h8uq5z8b	49	27	vary	vary	VBP
cord-003567-h8uq5z8b	49	28	[	[	-LRB-
cord-003567-h8uq5z8b	49	29	15	15	CD
cord-003567-h8uq5z8b	49	30	]	]	-RRB-
cord-003567-h8uq5z8b	49	31	.	.	.
cord-003567-h8uq5z8b	50	1	10	10	CD
cord-003567-h8uq5z8b	50	2	.	.	.
cord-003567-h8uq5z8b	51	1	Using	use	VBG
cord-003567-h8uq5z8b	51	2	human	human	JJ
cord-003567-h8uq5z8b	51	3	challenge	challenge	NN
cord-003567-h8uq5z8b	51	4	studies	study	NNS
cord-003567-h8uq5z8b	51	5	and	and	CC
cord-003567-h8uq5z8b	51	6	improving	improve	VBG
cord-003567-h8uq5z8b	51	7	animal	animal	NN
cord-003567-h8uq5z8b	51	8	models	model	NNS
cord-003567-h8uq5z8b	51	9	of	of	IN
cord-003567-h8uq5z8b	51	10	influenza	influenza	NN
cord-003567-h8uq5z8b	51	11	infection	infection	NN
cord-003567-h8uq5z8b	51	12	and	and	CC
cord-003567-h8uq5z8b	51	13	transmission	transmission	NN
cord-003567-h8uq5z8b	51	14	may	may	MD
cord-003567-h8uq5z8b	51	15	help	help	VB
cord-003567-h8uq5z8b	51	16	answer	answer	VB
cord-003567-h8uq5z8b	51	17	some	some	DT
cord-003567-h8uq5z8b	51	18	of	of	IN
cord-003567-h8uq5z8b	51	19	these	these	DT
cord-003567-h8uq5z8b	51	20	questions	question	NNS
cord-003567-h8uq5z8b	51	21	[	[	-LRB-
cord-003567-h8uq5z8b	51	22	3	3	CD
cord-003567-h8uq5z8b	51	23	]	]	-RRB-
cord-003567-h8uq5z8b	51	24	.	.	.
cord-003567-h8uq5z8b	52	1	However	however	RB
cord-003567-h8uq5z8b	52	2	,	,	,
cord-003567-h8uq5z8b	52	3	the	the	DT
cord-003567-h8uq5z8b	52	4	utility	utility	NN
cord-003567-h8uq5z8b	52	5	of	of	IN
cord-003567-h8uq5z8b	52	6	animal	animal	NN
cord-003567-h8uq5z8b	52	7	models	model	NNS
cord-003567-h8uq5z8b	52	8	hinges	hinge	VBZ
cord-003567-h8uq5z8b	52	9	on	on	IN
cord-003567-h8uq5z8b	52	10	selecting	select	VBG
cord-003567-h8uq5z8b	52	11	those	those	DT
cord-003567-h8uq5z8b	52	12	that	that	WDT
cord-003567-h8uq5z8b	52	13	are	be	VBP
cord-003567-h8uq5z8b	52	14	most	most	RBS
cord-003567-h8uq5z8b	52	15	relevant	relevant	JJ
cord-003567-h8uq5z8b	52	16	to	to	IN
cord-003567-h8uq5z8b	52	17	human	human	JJ
cord-003567-h8uq5z8b	52	18	pathogenesis	pathogenesis	NN
cord-003567-h8uq5z8b	52	19	and	and	CC
cord-003567-h8uq5z8b	52	20	immunity	immunity	NN
cord-003567-h8uq5z8b	52	21	.	.	.
cord-003567-h8uq5z8b	53	1	Improving	improve	VBG
cord-003567-h8uq5z8b	53	2	the	the	DT
cord-003567-h8uq5z8b	53	3	characterization	characterization	NN
cord-003567-h8uq5z8b	53	4	of	of	IN
cord-003567-h8uq5z8b	53	5	and	and	CC
cord-003567-h8uq5z8b	53	6	expanding	expand	VBG
cord-003567-h8uq5z8b	53	7	the	the	DT
cord-003567-h8uq5z8b	53	8	reagents	reagent	NNS
cord-003567-h8uq5z8b	53	9	for	for	IN
cord-003567-h8uq5z8b	53	10	these	these	DT
cord-003567-h8uq5z8b	53	11	models	model	NNS
cord-003567-h8uq5z8b	53	12	would	would	MD
cord-003567-h8uq5z8b	53	13	not	not	RB
cord-003567-h8uq5z8b	53	14	only	only	RB
cord-003567-h8uq5z8b	53	15	benefit	benefit	VB
cord-003567-h8uq5z8b	53	16	influenza	influenza	NN
cord-003567-h8uq5z8b	53	17	vaccine	vaccine	NN
cord-003567-h8uq5z8b	53	18	development	development	NN
cord-003567-h8uq5z8b	53	19	but	but	CC
cord-003567-h8uq5z8b	53	20	would	would	MD
cord-003567-h8uq5z8b	53	21	also	also	RB
cord-003567-h8uq5z8b	53	22	provide	provide	VB
cord-003567-h8uq5z8b	53	23	answers	answer	NNS
cord-003567-h8uq5z8b	53	24	to	to	IN
cord-003567-h8uq5z8b	53	25	immunological	immunological	JJ
cord-003567-h8uq5z8b	53	26	questions	question	NNS
cord-003567-h8uq5z8b	53	27	relevant	relevant	JJ
cord-003567-h8uq5z8b	53	28	to	to	IN
cord-003567-h8uq5z8b	53	29	other	other	JJ
cord-003567-h8uq5z8b	53	30	respiratory	respiratory	JJ
cord-003567-h8uq5z8b	53	31	virus	virus	NN
cord-003567-h8uq5z8b	53	32	infections	infection	NNS
cord-003567-h8uq5z8b	53	33	and	and	CC
cord-003567-h8uq5z8b	53	34	emerging	emerge	VBG
cord-003567-h8uq5z8b	53	35	infectious	infectious	JJ
cord-003567-h8uq5z8b	53	36	diseases	disease	NNS
cord-003567-h8uq5z8b	53	37	in	in	IN
cord-003567-h8uq5z8b	53	38	general	general	JJ
cord-003567-h8uq5z8b	53	39	.	.	.
cord-003567-h8uq5z8b	54	1	Recent	recent	JJ
cord-003567-h8uq5z8b	54	2	estimates	estimate	NNS
cord-003567-h8uq5z8b	54	3	place	place	VBP
cord-003567-h8uq5z8b	54	4	the	the	DT
cord-003567-h8uq5z8b	54	5	cost	cost	NN
cord-003567-h8uq5z8b	54	6	of	of	IN
cord-003567-h8uq5z8b	54	7	influenza	influenza	NN
cord-003567-h8uq5z8b	54	8	pandemics	pandemic	NNS
cord-003567-h8uq5z8b	54	9	at	at	IN
cord-003567-h8uq5z8b	54	10	upward	upward	RB
cord-003567-h8uq5z8b	54	11	of	of	IN
cord-003567-h8uq5z8b	54	12	$	$	$
cord-003567-h8uq5z8b	54	13	500	500	CD
cord-003567-h8uq5z8b	54	14	billion	billion	CD
cord-003567-h8uq5z8b	54	15	per	per	IN
cord-003567-h8uq5z8b	54	16	year	year	NN
cord-003567-h8uq5z8b	54	17	[	[	-LRB-
cord-003567-h8uq5z8b	54	18	23	23	CD
cord-003567-h8uq5z8b	54	19	]	]	-RRB-
cord-003567-h8uq5z8b	54	20	.	.	.
cord-003567-h8uq5z8b	55	1	In	in	IN
cord-003567-h8uq5z8b	55	2	this	this	DT
cord-003567-h8uq5z8b	55	3	context	context	NN
cord-003567-h8uq5z8b	55	4	,	,	,
cord-003567-h8uq5z8b	55	5	an	an	DT
cord-003567-h8uq5z8b	55	6	investment	investment	NN
cord-003567-h8uq5z8b	55	7	of	of	IN
cord-003567-h8uq5z8b	55	8	at	at	RB
cord-003567-h8uq5z8b	55	9	least	least	RBS
cord-003567-h8uq5z8b	55	10	$	$	$
cord-003567-h8uq5z8b	55	11	1	1	CD
cord-003567-h8uq5z8b	55	12	billion	billion	CD
cord-003567-h8uq5z8b	55	13	per	per	IN
cord-003567-h8uq5z8b	55	14	year	year	NN
cord-003567-h8uq5z8b	55	15	in	in	IN
cord-003567-h8uq5z8b	55	16	the	the	DT
cord-003567-h8uq5z8b	55	17	biomedical	biomedical	JJ
cord-003567-h8uq5z8b	55	18	research	research	NN
cord-003567-h8uq5z8b	55	19	effort	effort	NN
cord-003567-h8uq5z8b	55	20	to	to	TO
cord-003567-h8uq5z8b	55	21	achieve	achieve	VB
cord-003567-h8uq5z8b	55	22	a	a	DT
cord-003567-h8uq5z8b	55	23	solution	solution	NN
cord-003567-h8uq5z8b	55	24	for	for	IN
cord-003567-h8uq5z8b	55	25	protection	protection	NN
cord-003567-h8uq5z8b	55	26	against	against	IN
cord-003567-h8uq5z8b	55	27	pandemic	pandemic	NN
cord-003567-h8uq5z8b	55	28	influenza	influenza	NN
cord-003567-h8uq5z8b	55	29	seems	seem	VBZ
cord-003567-h8uq5z8b	55	30	justified	justified	JJ
cord-003567-h8uq5z8b	55	31	.	.	.
cord-003567-h8uq5z8b	56	1	In	in	IN
cord-003567-h8uq5z8b	56	2	addition	addition	NN
cord-003567-h8uq5z8b	56	3	,	,	,
cord-003567-h8uq5z8b	56	4	efforts	effort	NNS
cord-003567-h8uq5z8b	56	5	to	to	TO
cord-003567-h8uq5z8b	56	6	develop	develop	VB
cord-003567-h8uq5z8b	56	7	a	a	DT
cord-003567-h8uq5z8b	56	8	universal	universal	JJ
cord-003567-h8uq5z8b	56	9	influenza	influenza	NN
cord-003567-h8uq5z8b	56	10	vaccine	vaccine	NN
cord-003567-h8uq5z8b	56	11	,	,	,
cord-003567-h8uq5z8b	56	12	even	even	RB
cord-003567-h8uq5z8b	56	13	before	before	IN
cord-003567-h8uq5z8b	56	14	reaching	reach	VBG
cord-003567-h8uq5z8b	56	15	this	this	DT
cord-003567-h8uq5z8b	56	16	goal	goal	NN
cord-003567-h8uq5z8b	56	17	,	,	,
cord-003567-h8uq5z8b	56	18	will	will	MD
cord-003567-h8uq5z8b	56	19	likely	likely	RB
cord-003567-h8uq5z8b	56	20	lead	lead	VB
cord-003567-h8uq5z8b	56	21	to	to	IN
cord-003567-h8uq5z8b	56	22	improved	improve	VBN
cord-003567-h8uq5z8b	56	23	seasonal	seasonal	JJ
cord-003567-h8uq5z8b	56	24	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	56	25	,	,	,
cord-003567-h8uq5z8b	56	26	with	with	IN
cord-003567-h8uq5z8b	56	27	the	the	DT
cord-003567-h8uq5z8b	56	28	potential	potential	NN
cord-003567-h8uq5z8b	56	29	to	to	TO
cord-003567-h8uq5z8b	56	30	reduce	reduce	VB
cord-003567-h8uq5z8b	56	31	morbidity	morbidity	NN
cord-003567-h8uq5z8b	56	32	rates	rate	NNS
cord-003567-h8uq5z8b	56	33	and	and	CC
cord-003567-h8uq5z8b	56	34	save	save	VB
cord-003567-h8uq5z8b	56	35	tens	ten	NNS
cord-003567-h8uq5z8b	56	36	of	of	IN
cord-003567-h8uq5z8b	56	37	thousands	thousand	NNS
cord-003567-h8uq5z8b	56	38	of	of	IN
cord-003567-h8uq5z8b	56	39	lives	life	NNS
cord-003567-h8uq5z8b	56	40	each	each	DT
cord-003567-h8uq5z8b	56	41	year	year	NN
cord-003567-h8uq5z8b	56	42	.	.	.
cord-003567-h8uq5z8b	57	1	Solving	solve	VBG
cord-003567-h8uq5z8b	57	2	this	this	DT
cord-003567-h8uq5z8b	57	3	problem	problem	NN
cord-003567-h8uq5z8b	57	4	is	be	VBZ
cord-003567-h8uq5z8b	57	5	potentially	potentially	RB
cord-003567-h8uq5z8b	57	6	achievable	achievable	JJ
cord-003567-h8uq5z8b	57	7	with	with	IN
cord-003567-h8uq5z8b	57	8	today	today	NN
cord-003567-h8uq5z8b	57	9	's	's	POS
cord-003567-h8uq5z8b	57	10	technology	technology	NN
cord-003567-h8uq5z8b	57	11	,	,	,
cord-003567-h8uq5z8b	57	12	and	and	CC
cord-003567-h8uq5z8b	57	13	with	with	IN
cord-003567-h8uq5z8b	57	14	an	an	DT
cord-003567-h8uq5z8b	57	15	organized	organized	JJ
cord-003567-h8uq5z8b	57	16	and	and	CC
cord-003567-h8uq5z8b	57	17	sustained	sustained	JJ
cord-003567-h8uq5z8b	57	18	focus	focus	NN
cord-003567-h8uq5z8b	57	19	on	on	IN
cord-003567-h8uq5z8b	57	20	interventions	intervention	NNS
cord-003567-h8uq5z8b	57	21	for	for	IN
cord-003567-h8uq5z8b	57	22	influenza	influenza	NN
cord-003567-h8uq5z8b	57	23	and	and	CC
cord-003567-h8uq5z8b	57	24	other	other	JJ
cord-003567-h8uq5z8b	57	25	potential	potential	JJ
cord-003567-h8uq5z8b	57	26	emerging	emerge	VBG
cord-003567-h8uq5z8b	57	27	infectious	infectious	JJ
cord-003567-h8uq5z8b	57	28	threats	threat	NNS
cord-003567-h8uq5z8b	57	29	,	,	,
cord-003567-h8uq5z8b	57	30	more	more	RBR
cord-003567-h8uq5z8b	57	31	advanced	advanced	JJ
cord-003567-h8uq5z8b	57	32	approaches	approach	NNS
cord-003567-h8uq5z8b	57	33	could	could	MD
cord-003567-h8uq5z8b	57	34	be	be	VB
cord-003567-h8uq5z8b	57	35	rapidly	rapidly	RB
cord-003567-h8uq5z8b	57	36	developed	develop	VBN
cord-003567-h8uq5z8b	57	37	.	.	.
cord-003567-h8uq5z8b	58	1	Finally	finally	RB
cord-003567-h8uq5z8b	58	2	,	,	,
cord-003567-h8uq5z8b	58	3	gaps	gap	NNS
cord-003567-h8uq5z8b	58	4	remain	remain	VBP
cord-003567-h8uq5z8b	58	5	in	in	IN
cord-003567-h8uq5z8b	58	6	our	-PRON-	PRP$
cord-003567-h8uq5z8b	58	7	understanding	understanding	NN
cord-003567-h8uq5z8b	58	8	of	of	IN
cord-003567-h8uq5z8b	58	9	influenza	influenza	NN
cord-003567-h8uq5z8b	58	10	biology	biology	NN
cord-003567-h8uq5z8b	58	11	and	and	CC
cord-003567-h8uq5z8b	58	12	immunity	immunity	NN
cord-003567-h8uq5z8b	58	13	and	and	CC
cord-003567-h8uq5z8b	58	14	methods	method	NNS
cord-003567-h8uq5z8b	58	15	to	to	TO
cord-003567-h8uq5z8b	58	16	produce	produce	VB
cord-003567-h8uq5z8b	58	17	highly	highly	RB
cord-003567-h8uq5z8b	58	18	effective	effective	JJ
cord-003567-h8uq5z8b	58	19	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	58	20	.	.	.
cord-003567-h8uq5z8b	59	1	To	to	TO
cord-003567-h8uq5z8b	59	2	close	close	VB
cord-003567-h8uq5z8b	59	3	those	those	DT
cord-003567-h8uq5z8b	59	4	gaps	gap	NNS
cord-003567-h8uq5z8b	59	5	,	,	,
cord-003567-h8uq5z8b	59	6	it	-PRON-	PRP
cord-003567-h8uq5z8b	59	7	will	will	MD
cord-003567-h8uq5z8b	59	8	be	be	VB
cord-003567-h8uq5z8b	59	9	important	important	JJ
cord-003567-h8uq5z8b	59	10	to	to	TO
cord-003567-h8uq5z8b	59	11	align	align	VB
cord-003567-h8uq5z8b	59	12	the	the	DT
cord-003567-h8uq5z8b	59	13	interests	interest	NNS
cord-003567-h8uq5z8b	59	14	of	of	IN
cord-003567-h8uq5z8b	59	15	all	all	PDT
cord-003567-h8uq5z8b	59	16	the	the	DT
cord-003567-h8uq5z8b	59	17	stakeholders	stakeholder	NNS
cord-003567-h8uq5z8b	59	18	preparing	prepare	VBG
cord-003567-h8uq5z8b	59	19	for	for	IN
cord-003567-h8uq5z8b	59	20	the	the	DT
cord-003567-h8uq5z8b	59	21	next	next	JJ
cord-003567-h8uq5z8b	59	22	pandemic	pandemic	NN
cord-003567-h8uq5z8b	59	23	.	.	.
cord-003567-h8uq5z8b	60	1	Priorities	priority	NNS
cord-003567-h8uq5z8b	60	2	of	of	IN
cord-003567-h8uq5z8b	60	3	public	public	JJ
cord-003567-h8uq5z8b	60	4	health	health	NN
cord-003567-h8uq5z8b	60	5	officials	official	NNS
cord-003567-h8uq5z8b	60	6	in	in	IN
cord-003567-h8uq5z8b	60	7	lower-	lower-	CD
cord-003567-h8uq5z8b	60	8	,	,	,
cord-003567-h8uq5z8b	60	9	middle-	middle-	NN
cord-003567-h8uq5z8b	60	10	,	,	,
cord-003567-h8uq5z8b	60	11	and	and	CC
cord-003567-h8uq5z8b	60	12	high	high	JJ
cord-003567-h8uq5z8b	60	13	-	-	HYPH
cord-003567-h8uq5z8b	60	14	income	income	NN
cord-003567-h8uq5z8b	60	15	countries	country	NNS
cord-003567-h8uq5z8b	60	16	,	,	,
cord-003567-h8uq5z8b	60	17	academic	academic	JJ
cord-003567-h8uq5z8b	60	18	researchers	researcher	NNS
cord-003567-h8uq5z8b	60	19	,	,	,
cord-003567-h8uq5z8b	60	20	regulatory	regulatory	JJ
cord-003567-h8uq5z8b	60	21	bodies	body	NNS
cord-003567-h8uq5z8b	60	22	,	,	,
cord-003567-h8uq5z8b	60	23	major	major	JJ
cord-003567-h8uq5z8b	60	24	funders	funder	NNS
cord-003567-h8uq5z8b	60	25	,	,	,
cord-003567-h8uq5z8b	60	26	and	and	CC
cord-003567-h8uq5z8b	60	27	pharmaceutical	pharmaceutical	NN
cord-003567-h8uq5z8b	60	28	companies	company	NNS
cord-003567-h8uq5z8b	60	29	must	must	MD
cord-003567-h8uq5z8b	60	30	be	be	VB
cord-003567-h8uq5z8b	60	31	understood	understand	VBN
cord-003567-h8uq5z8b	60	32	and	and	CC
cord-003567-h8uq5z8b	60	33	collectively	collectively	RB
cord-003567-h8uq5z8b	60	34	addressed	address	VBN
cord-003567-h8uq5z8b	60	35	to	to	TO
cord-003567-h8uq5z8b	60	36	face	face	VB
cord-003567-h8uq5z8b	60	37	the	the	DT
cord-003567-h8uq5z8b	60	38	logistical	logistical	JJ
cord-003567-h8uq5z8b	60	39	and	and	CC
cord-003567-h8uq5z8b	60	40	scientific	scientific	JJ
cord-003567-h8uq5z8b	60	41	challenges	challenge	NNS
cord-003567-h8uq5z8b	60	42	ahead	ahead	RB
cord-003567-h8uq5z8b	60	43	[	[	-LRB-
cord-003567-h8uq5z8b	60	44	24	24	CD
cord-003567-h8uq5z8b	60	45	]	]	-RRB-
cord-003567-h8uq5z8b	60	46	.	.	.
cord-003567-h8uq5z8b	61	1	Thanks	thank	NNS
cord-003567-h8uq5z8b	61	2	to	to	IN
cord-003567-h8uq5z8b	61	3	scientific	scientific	JJ
cord-003567-h8uq5z8b	61	4	and	and	CC
cord-003567-h8uq5z8b	61	5	technological	technological	JJ
cord-003567-h8uq5z8b	61	6	breakthroughs	breakthrough	NNS
cord-003567-h8uq5z8b	61	7	of	of	IN
cord-003567-h8uq5z8b	61	8	the	the	DT
cord-003567-h8uq5z8b	61	9	past	past	JJ
cord-003567-h8uq5z8b	61	10	decade	decade	NN
cord-003567-h8uq5z8b	61	11	,	,	,
cord-003567-h8uq5z8b	61	12	vaccinology	vaccinology	NN
cord-003567-h8uq5z8b	61	13	is	be	VBZ
cord-003567-h8uq5z8b	61	14	experiencing	experience	VBG
cord-003567-h8uq5z8b	61	15	a	a	DT
cord-003567-h8uq5z8b	61	16	revolution	revolution	NN
cord-003567-h8uq5z8b	61	17	.	.	.
cord-003567-h8uq5z8b	62	1	May	May	MD
cord-003567-h8uq5z8b	62	2	we	-PRON-	PRP
cord-003567-h8uq5z8b	62	3	find	find	VB
cord-003567-h8uq5z8b	62	4	the	the	DT
cord-003567-h8uq5z8b	62	5	resolve	resolve	NN
cord-003567-h8uq5z8b	62	6	,	,	,
cord-003567-h8uq5z8b	62	7	political	political	JJ
cord-003567-h8uq5z8b	62	8	will	will	NN
cord-003567-h8uq5z8b	62	9	,	,	,
cord-003567-h8uq5z8b	62	10	and	and	CC
cord-003567-h8uq5z8b	62	11	new	new	JJ
cord-003567-h8uq5z8b	62	12	business	business	NN
cord-003567-h8uq5z8b	62	13	plans	plan	NNS
cord-003567-h8uq5z8b	62	14	to	to	TO
cord-003567-h8uq5z8b	62	15	take	take	VB
cord-003567-h8uq5z8b	62	16	full	full	JJ
cord-003567-h8uq5z8b	62	17	advantage	advantage	NN
cord-003567-h8uq5z8b	62	18	of	of	IN
cord-003567-h8uq5z8b	62	19	these	these	DT
cord-003567-h8uq5z8b	62	20	new	new	JJ
cord-003567-h8uq5z8b	62	21	opportunities	opportunity	NNS
cord-003567-h8uq5z8b	62	22	and	and	CC
cord-003567-h8uq5z8b	62	23	prepare	prepare	VB
cord-003567-h8uq5z8b	62	24	ourselves	-PRON-	PRP
cord-003567-h8uq5z8b	62	25	before	before	IN
cord-003567-h8uq5z8b	62	26	the	the	DT
cord-003567-h8uq5z8b	62	27	next	next	JJ
cord-003567-h8uq5z8b	62	28	pandemic	pandemic	NN
cord-003567-h8uq5z8b	62	29	arrives	arrive	VBZ
cord-003567-h8uq5z8b	62	30	.	.	.
cord-003567-h8uq5z8b	63	1	Updating	update	VBG
cord-003567-h8uq5z8b	63	2	the	the	DT
cord-003567-h8uq5z8b	63	3	accounts	account	NNS
cord-003567-h8uq5z8b	63	4	:	:	:
cord-003567-h8uq5z8b	63	5	global	global	JJ
cord-003567-h8uq5z8b	63	6	mortality	mortality	NN
cord-003567-h8uq5z8b	63	7	of	of	IN
cord-003567-h8uq5z8b	63	8	the	the	DT
cord-003567-h8uq5z8b	63	9	1918	1918	CD
cord-003567-h8uq5z8b	63	10	-	-	SYM
cord-003567-h8uq5z8b	63	11	1920	1920	CD
cord-003567-h8uq5z8b	63	12	"	"	``
cord-003567-h8uq5z8b	63	13	Spanish	spanish	JJ
cord-003567-h8uq5z8b	63	14	"	"	''
cord-003567-h8uq5z8b	63	15	influenza	influenza	NN
cord-003567-h8uq5z8b	63	16	pandemic	pandemic	NN
cord-003567-h8uq5z8b	63	17	Influenza	Influenza	NNP
cord-003567-h8uq5z8b	63	18	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	63	19	:	:	:
cord-003567-h8uq5z8b	63	20	good	good	JJ
cord-003567-h8uq5z8b	63	21	,	,	,
cord-003567-h8uq5z8b	63	22	but	but	CC
cord-003567-h8uq5z8b	63	23	we	-PRON-	PRP
cord-003567-h8uq5z8b	63	24	can	can	MD
cord-003567-h8uq5z8b	63	25	do	do	VB
cord-003567-h8uq5z8b	63	26	better	well	RBR
cord-003567-h8uq5z8b	63	27	Making	make	VBG
cord-003567-h8uq5z8b	63	28	universal	universal	JJ
cord-003567-h8uq5z8b	63	29	influenza	influenza	NN
cord-003567-h8uq5z8b	63	30	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	63	31	:	:	:
cord-003567-h8uq5z8b	63	32	lessons	lesson	NNS
cord-003567-h8uq5z8b	63	33	from	from	IN
cord-003567-h8uq5z8b	63	34	the	the	DT
cord-003567-h8uq5z8b	63	35	1918	1918	CD
cord-003567-h8uq5z8b	63	36	pandemic	pandemic	NN
cord-003567-h8uq5z8b	64	1	Can	Can	MD
cord-003567-h8uq5z8b	64	2	we	-PRON-	PRP
cord-003567-h8uq5z8b	64	3	predict	predict	VB
cord-003567-h8uq5z8b	64	4	the	the	DT
cord-003567-h8uq5z8b	64	5	next	next	JJ
cord-003567-h8uq5z8b	64	6	influenza	influenza	NN
cord-003567-h8uq5z8b	64	7	pandemics	pandemic	NNS
cord-003567-h8uq5z8b	64	8	?	?	.
cord-003567-h8uq5z8b	65	1	Antibody	antibody	NN
cord-003567-h8uq5z8b	65	2	determinants	determinant	NNS
cord-003567-h8uq5z8b	65	3	of	of	IN
cord-003567-h8uq5z8b	65	4	influenza	influenza	NN
cord-003567-h8uq5z8b	65	5	immunity	immunity	NN
cord-003567-h8uq5z8b	65	6	The	the	DT
cord-003567-h8uq5z8b	65	7	way	way	NN
cord-003567-h8uq5z8b	65	8	forward	forward	RB
cord-003567-h8uq5z8b	65	9	:	:	:
cord-003567-h8uq5z8b	65	10	potentiating	potentiate	VBG
cord-003567-h8uq5z8b	65	11	protective	protective	JJ
cord-003567-h8uq5z8b	65	12	immunity	immunity	NN
cord-003567-h8uq5z8b	65	13	to	to	IN
cord-003567-h8uq5z8b	65	14	novel	novel	NN
cord-003567-h8uq5z8b	65	15	and	and	CC
cord-003567-h8uq5z8b	65	16	pandemic	pandemic	NN
cord-003567-h8uq5z8b	65	17	influenza	influenza	NN
cord-003567-h8uq5z8b	65	18	through	through	IN
cord-003567-h8uq5z8b	65	19	engagement	engagement	NN
cord-003567-h8uq5z8b	65	20	of	of	IN
cord-003567-h8uq5z8b	65	21	memory	memory	NN
cord-003567-h8uq5z8b	65	22	CD4	CD4	NNP
cord-003567-h8uq5z8b	65	23	T	T	NNP
cord-003567-h8uq5z8b	65	24	cells	cell	NNS
cord-003567-h8uq5z8b	66	1	Immunodominance	immunodominance	NN
cord-003567-h8uq5z8b	66	2	and	and	CC
cord-003567-h8uq5z8b	66	3	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	66	4	variation	variation	NN
cord-003567-h8uq5z8b	66	5	of	of	IN
cord-003567-h8uq5z8b	66	6	influenza	influenza	NN
cord-003567-h8uq5z8b	66	7	virus	virus	NN
cord-003567-h8uq5z8b	66	8	hemagglutinin	hemagglutinin	NN
cord-003567-h8uq5z8b	66	9	:	:	:
cord-003567-h8uq5z8b	66	10	implications	implication	NNS
cord-003567-h8uq5z8b	66	11	for	for	IN
cord-003567-h8uq5z8b	66	12	design	design	NN
cord-003567-h8uq5z8b	66	13	of	of	IN
cord-003567-h8uq5z8b	66	14	universal	universal	JJ
cord-003567-h8uq5z8b	66	15	vaccine	vaccine	NN
cord-003567-h8uq5z8b	66	16	immunogens	immunogen	VBZ
cord-003567-h8uq5z8b	66	17	Dynamic	dynamic	JJ
cord-003567-h8uq5z8b	66	18	perspectives	perspective	NNS
cord-003567-h8uq5z8b	66	19	on	on	IN
cord-003567-h8uq5z8b	66	20	the	the	DT
cord-003567-h8uq5z8b	66	21	search	search	NN
cord-003567-h8uq5z8b	66	22	for	for	IN
cord-003567-h8uq5z8b	66	23	a	a	DT
cord-003567-h8uq5z8b	66	24	universal	universal	JJ
cord-003567-h8uq5z8b	66	25	influenza	influenza	NN
cord-003567-h8uq5z8b	66	26	vaccine	vaccine	NN
cord-003567-h8uq5z8b	67	1	Universal	universal	JJ
cord-003567-h8uq5z8b	67	2	influenza	influenza	NN
cord-003567-h8uq5z8b	67	3	vaccine	vaccine	NN
cord-003567-h8uq5z8b	67	4	approaches	approach	NNS
cord-003567-h8uq5z8b	67	5	employing	employ	VBG
cord-003567-h8uq5z8b	67	6	full	full	JJ
cord-003567-h8uq5z8b	67	7	-	-	HYPH
cord-003567-h8uq5z8b	67	8	length	length	NN
cord-003567-h8uq5z8b	67	9	or	or	CC
cord-003567-h8uq5z8b	67	10	head	head	NN
cord-003567-h8uq5z8b	67	11	-	-	HYPH
cord-003567-h8uq5z8b	67	12	only	only	RB
cord-003567-h8uq5z8b	67	13	HA	HA	NNP
cord-003567-h8uq5z8b	67	14	proteins	protein	VBZ
cord-003567-h8uq5z8b	67	15	Universal	Universal	NNP
cord-003567-h8uq5z8b	67	16	influenza	influenza	NN
cord-003567-h8uq5z8b	67	17	virus	virus	NN
cord-003567-h8uq5z8b	67	18	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	67	19	that	that	WDT
cord-003567-h8uq5z8b	67	20	target	target	VBP
cord-003567-h8uq5z8b	67	21	the	the	DT
cord-003567-h8uq5z8b	67	22	conserved	conserve	VBN
cord-003567-h8uq5z8b	67	23	hemagglutinin	hemagglutinin	NN
cord-003567-h8uq5z8b	67	24	stalk	stalk	NN
cord-003567-h8uq5z8b	67	25	and	and	CC
cord-003567-h8uq5z8b	67	26	conserved	conserve	VBN
cord-003567-h8uq5z8b	67	27	sites	site	NNS
cord-003567-h8uq5z8b	67	28	in	in	IN
cord-003567-h8uq5z8b	67	29	the	the	DT
cord-003567-h8uq5z8b	67	30	head	head	NN
cord-003567-h8uq5z8b	67	31	domain	domain	NN
cord-003567-h8uq5z8b	68	1	The	the	DT
cord-003567-h8uq5z8b	68	2	role	role	NN
cord-003567-h8uq5z8b	68	3	of	of	IN
cord-003567-h8uq5z8b	68	4	M2e	M2e	NNP
cord-003567-h8uq5z8b	68	5	in	in	IN
cord-003567-h8uq5z8b	68	6	the	the	DT
cord-003567-h8uq5z8b	68	7	development	development	NN
cord-003567-h8uq5z8b	68	8	of	of	IN
cord-003567-h8uq5z8b	68	9	universal	universal	JJ
cord-003567-h8uq5z8b	68	10	influenza	influenza	NN
cord-003567-h8uq5z8b	68	11	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	68	12	Neuraminidase	Neuraminidase	NNP
cord-003567-h8uq5z8b	68	13	,	,	,
cord-003567-h8uq5z8b	68	14	the	the	DT
cord-003567-h8uq5z8b	68	15	forgotten	forget	VBN
cord-003567-h8uq5z8b	68	16	surface	surface	NN
cord-003567-h8uq5z8b	68	17	antigen	antigen	NN
cord-003567-h8uq5z8b	68	18	,	,	,
cord-003567-h8uq5z8b	68	19	emerges	emerge	VBZ
cord-003567-h8uq5z8b	68	20	as	as	IN
cord-003567-h8uq5z8b	68	21	an	an	DT
cord-003567-h8uq5z8b	68	22	influenza	influenza	NN
cord-003567-h8uq5z8b	68	23	vaccine	vaccine	NN
cord-003567-h8uq5z8b	68	24	target	target	NN
cord-003567-h8uq5z8b	68	25	for	for	IN
cord-003567-h8uq5z8b	68	26	broadened	broaden	VBN
cord-003567-h8uq5z8b	68	27	protection	protection	NN
cord-003567-h8uq5z8b	68	28	How	how	WRB
cord-003567-h8uq5z8b	68	29	live	live	VBP
cord-003567-h8uq5z8b	68	30	attenuated	attenuated	JJ
cord-003567-h8uq5z8b	68	31	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	68	32	can	can	MD
cord-003567-h8uq5z8b	68	33	Inform	inform	VB
cord-003567-h8uq5z8b	68	34	the	the	DT
cord-003567-h8uq5z8b	68	35	development	development	NN
cord-003567-h8uq5z8b	68	36	of	of	IN
cord-003567-h8uq5z8b	68	37	broadly	broadly	RB
cord-003567-h8uq5z8b	68	38	cross	cross	JJ
cord-003567-h8uq5z8b	68	39	-	-	JJ
cord-003567-h8uq5z8b	68	40	protective	protective	JJ
cord-003567-h8uq5z8b	68	41	influenza	influenza	NN
cord-003567-h8uq5z8b	68	42	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	68	43	New	new	JJ
cord-003567-h8uq5z8b	68	44	vaccine	vaccine	NN
cord-003567-h8uq5z8b	68	45	design	design	NN
cord-003567-h8uq5z8b	68	46	and	and	CC
cord-003567-h8uq5z8b	68	47	delivery	delivery	NN
cord-003567-h8uq5z8b	68	48	technologies	technology	NNS
cord-003567-h8uq5z8b	68	49	Influenza	Influenza	NNP
cord-003567-h8uq5z8b	68	50	immunization	immunization	NN
cord-003567-h8uq5z8b	68	51	in	in	IN
cord-003567-h8uq5z8b	68	52	low	low	JJ
cord-003567-h8uq5z8b	68	53	-	-	HYPH
cord-003567-h8uq5z8b	68	54	and	and	CC
cord-003567-h8uq5z8b	68	55	middle	middle	JJ
cord-003567-h8uq5z8b	68	56	-	-	HYPH
cord-003567-h8uq5z8b	68	57	income	income	NN
cord-003567-h8uq5z8b	68	58	countries	country	NNS
cord-003567-h8uq5z8b	68	59	:	:	:
cord-003567-h8uq5z8b	68	60	preparing	prepare	VBG
cord-003567-h8uq5z8b	68	61	for	for	IN
cord-003567-h8uq5z8b	68	62	next	next	JJ
cord-003567-h8uq5z8b	68	63	-	-	HYPH
cord-003567-h8uq5z8b	68	64	generation	generation	NN
cord-003567-h8uq5z8b	68	65	influenza	influenza	NN
cord-003567-h8uq5z8b	68	66	vaccines	vaccine	NNS
cord-003567-h8uq5z8b	68	67	Novel	Novel	NNP
cord-003567-h8uq5z8b	68	68	vaccine	vaccine	NN
cord-003567-h8uq5z8b	68	69	technologies	technology	NNS
cord-003567-h8uq5z8b	68	70	:	:	:
cord-003567-h8uq5z8b	68	71	essential	essential	JJ
cord-003567-h8uq5z8b	68	72	components	component	NNS
cord-003567-h8uq5z8b	68	73	of	of	IN
cord-003567-h8uq5z8b	68	74	an	an	DT
cord-003567-h8uq5z8b	68	75	adequate	adequate	JJ
cord-003567-h8uq5z8b	68	76	response	response	NN
cord-003567-h8uq5z8b	68	77	to	to	IN
cord-003567-h8uq5z8b	68	78	emerging	emerge	VBG
cord-003567-h8uq5z8b	68	79	viral	viral	JJ
cord-003567-h8uq5z8b	68	80	diseases	disease	NNS
cord-003567-h8uq5z8b	68	81	Emerging	emerge	VBG
cord-003567-h8uq5z8b	68	82	viral	viral	JJ
cord-003567-h8uq5z8b	68	83	diseases	disease	NNS
cord-003567-h8uq5z8b	68	84	from	from	IN
cord-003567-h8uq5z8b	68	85	a	a	DT
cord-003567-h8uq5z8b	68	86	vaccinology	vaccinology	NN
cord-003567-h8uq5z8b	68	87	perspective	perspective	NN
cord-003567-h8uq5z8b	68	88	:	:	:
cord-003567-h8uq5z8b	68	89	preparing	prepare	VBG
cord-003567-h8uq5z8b	68	90	for	for	IN
cord-003567-h8uq5z8b	68	91	the	the	DT
cord-003567-h8uq5z8b	68	92	next	next	JJ
cord-003567-h8uq5z8b	68	93	pandemic	pandemic	NN
cord-003567-h8uq5z8b	68	94	Advances	advance	NNS
cord-003567-h8uq5z8b	68	95	in	in	IN
cord-003567-h8uq5z8b	68	96	antiviral	antiviral	JJ
cord-003567-h8uq5z8b	68	97	vaccine	vaccine	NN
cord-003567-h8uq5z8b	68	98	development	development	NN
cord-003567-h8uq5z8b	69	1	A	a	DT
cord-003567-h8uq5z8b	69	2	universal	universal	JJ
cord-003567-h8uq5z8b	69	3	influenza	influenza	NN
cord-003567-h8uq5z8b	69	4	vaccine	vaccine	NN
cord-003567-h8uq5z8b	69	5	:	:	:
cord-003567-h8uq5z8b	69	6	the	the	DT
cord-003567-h8uq5z8b	69	7	strategic	strategic	JJ
cord-003567-h8uq5z8b	69	8	plan	plan	NN
cord-003567-h8uq5z8b	69	9	for	for	IN
cord-003567-h8uq5z8b	69	10	the	the	DT
cord-003567-h8uq5z8b	69	11	National	National	NNP
cord-003567-h8uq5z8b	69	12	Institute	Institute	NNP
cord-003567-h8uq5z8b	69	13	of	of	IN
cord-003567-h8uq5z8b	69	14	Allergy	Allergy	NNP
cord-003567-h8uq5z8b	69	15	and	and	CC
cord-003567-h8uq5z8b	69	16	Infectious	Infectious	NNP
cord-003567-h8uq5z8b	69	17	Diseases	Diseases	NNPS
cord-003567-h8uq5z8b	70	1	Historical	historical	JJ
cord-003567-h8uq5z8b	70	2	estimates	estimate	NNS
cord-003567-h8uq5z8b	70	3	of	of	IN
cord-003567-h8uq5z8b	70	4	world	world	NN
cord-003567-h8uq5z8b	70	5	population	population	NN
cord-003567-h8uq5z8b	70	6	On	on	IN
cord-003567-h8uq5z8b	70	7	the	the	DT
cord-003567-h8uq5z8b	70	8	doctrine	doctrine	NN
cord-003567-h8uq5z8b	70	9	of	of	IN
cord-003567-h8uq5z8b	70	10	original	original	JJ
cord-003567-h8uq5z8b	70	11	antigenic	antigenic	JJ
cord-003567-h8uq5z8b	70	12	sin	sin	NN
cord-003567-h8uq5z8b	70	13	Pandemic	Pandemic	NNP
cord-003567-h8uq5z8b	70	14	risk	risk	NN
cord-003567-h8uq5z8b	71	1	:	:	:
cord-003567-h8uq5z8b	71	2	how	how	WRB
cord-003567-h8uq5z8b	71	3	large	large	JJ
cord-003567-h8uq5z8b	71	4	are	be	VBP
cord-003567-h8uq5z8b	71	5	the	the	DT
cord-003567-h8uq5z8b	71	6	expected	expect	VBN
cord-003567-h8uq5z8b	71	7	losses	loss	NNS
cord-003567-h8uq5z8b	71	8	?	?	.
cord-003567-h8uq5z8b	72	1	Vaccine	vaccine	NN
cord-003567-h8uq5z8b	72	2	development	development	NN
cord-003567-h8uq5z8b	72	3	in	in	IN
cord-003567-h8uq5z8b	72	4	the	the	DT
cord-003567-h8uq5z8b	72	5	twenty	twenty	CD
cord-003567-h8uq5z8b	72	6	-	-	HYPH
cord-003567-h8uq5z8b	72	7	first	first	JJ
cord-003567-h8uq5z8b	72	8	century	century	NN
cord-003567-h8uq5z8b	72	9	:	:	:
cord-003567-h8uq5z8b	72	10	changing	change	VBG
cord-003567-h8uq5z8b	72	11	paradigms	paradigm	NNS
cord-003567-h8uq5z8b	72	12	for	for	IN
cord-003567-h8uq5z8b	72	13	elusive	elusive	JJ
cord-003567-h8uq5z8b	72	14	viruses	virus	NNS
cord-003567-h8uq5z8b	73	1	We	-PRON-	PRP
cord-003567-h8uq5z8b	73	2	thank	thank	VBP
cord-003567-h8uq5z8b	73	3	our	-PRON-	PRP$
cord-003567-h8uq5z8b	73	4	colleagues	colleague	NNS
cord-003567-h8uq5z8b	73	5	at	at	IN
cord-003567-h8uq5z8b	73	6	the	the	DT
cord-003567-h8uq5z8b	73	7	National	National	NNP