id	sid	tid	token	lemma	pos
cord-005081-kxrzv16n	1	1	key	key	JJ
cord-005081-kxrzv16n	2	1	:	:	:
cord-005081-kxrzv16n	2	2	cord-005081-kxrzv16n	cord-005081-kxrzv16n	CD
cord-005081-kxrzv16n	2	3	authors	author	NNS
cord-005081-kxrzv16n	2	4	:	:	:
cord-005081-kxrzv16n	2	5	Kiselev	Kiselev	NNP
cord-005081-kxrzv16n	2	6	,	,	,
cord-005081-kxrzv16n	2	7	O.	O.	NNP
cord-005081-kxrzv16n	2	8	I.	I.	NNP
cord-005081-kxrzv16n	2	9	title	title	NN
cord-005081-kxrzv16n	2	10	:	:	:
cord-005081-kxrzv16n	2	11	Progress	progress	VB
cord-005081-kxrzv16n	2	12	in	in	IN
cord-005081-kxrzv16n	2	13	the	the	DT
cord-005081-kxrzv16n	2	14	development	development	NN
cord-005081-kxrzv16n	2	15	of	of	IN
cord-005081-kxrzv16n	2	16	pandemic	pandemic	NN
cord-005081-kxrzv16n	2	17	influenza	influenza	NN
cord-005081-kxrzv16n	2	18	vaccines	vaccine	NNS
cord-005081-kxrzv16n	2	19	and	and	CC
cord-005081-kxrzv16n	2	20	their	-PRON-	PRP$
cord-005081-kxrzv16n	2	21	production	production	NN
cord-005081-kxrzv16n	2	22	technologies	technology	NNS
cord-005081-kxrzv16n	2	23	date	date	NN
cord-005081-kxrzv16n	2	24	:	:	:
cord-005081-kxrzv16n	2	25	2010	2010	CD
cord-005081-kxrzv16n	2	26	-	-	SYM
cord-005081-kxrzv16n	2	27	11	11	CD
cord-005081-kxrzv16n	2	28	-	-	SYM
cord-005081-kxrzv16n	2	29	12	12	CD
cord-005081-kxrzv16n	2	30	journal	journal	NN
cord-005081-kxrzv16n	2	31	:	:	:
cord-005081-kxrzv16n	3	1	Appl	Appl	NNP
cord-005081-kxrzv16n	3	2	DOI	DOI	NNP
cord-005081-kxrzv16n	3	3	:	:	:
cord-005081-kxrzv16n	3	4	10.1134	10.1134	CD
cord-005081-kxrzv16n	3	5	/	/	SYM
cord-005081-kxrzv16n	3	6	s0003683810090024	s0003683810090024	NN
cord-005081-kxrzv16n	3	7	sha	sha	NNP
cord-005081-kxrzv16n	3	8	:	:	:
cord-005081-kxrzv16n	3	9	87d8c9aeb5a60f333c786846b6e1ebb504331d35	87d8c9aeb5a60f333c786846b6e1ebb504331d35	CD
cord-005081-kxrzv16n	3	10	doc_id	doc_id	CD
cord-005081-kxrzv16n	3	11	:	:	:
cord-005081-kxrzv16n	3	12	5081	5081	CD
cord-005081-kxrzv16n	3	13	cord_uid	cord_uid	NNS
cord-005081-kxrzv16n	3	14	:	:	:
cord-005081-kxrzv16n	4	1	kxrzv16n	kxrzv16n	NNP
cord-005081-kxrzv16n	5	1	This	this	DT
cord-005081-kxrzv16n	5	2	article	article	NN
cord-005081-kxrzv16n	5	3	analyzes	analyze	VBZ
cord-005081-kxrzv16n	5	4	the	the	DT
cord-005081-kxrzv16n	5	5	current	current	JJ
cord-005081-kxrzv16n	5	6	situation	situation	NN
cord-005081-kxrzv16n	5	7	in	in	IN
cord-005081-kxrzv16n	5	8	the	the	DT
cord-005081-kxrzv16n	5	9	field	field	NN
cord-005081-kxrzv16n	5	10	of	of	IN
cord-005081-kxrzv16n	5	11	construction	construction	NN
cord-005081-kxrzv16n	5	12	and	and	CC
cord-005081-kxrzv16n	5	13	production	production	NN
cord-005081-kxrzv16n	5	14	of	of	IN
cord-005081-kxrzv16n	5	15	pandemic	pandemic	NN
cord-005081-kxrzv16n	5	16	influenza	influenza	NN
cord-005081-kxrzv16n	5	17	vaccines	vaccine	NNS
cord-005081-kxrzv16n	5	18	.	.	.
cord-005081-kxrzv16n	6	1	The	the	DT
cord-005081-kxrzv16n	6	2	main	main	JJ
cord-005081-kxrzv16n	6	3	task	task	NN
cord-005081-kxrzv16n	6	4	of	of	IN
cord-005081-kxrzv16n	6	5	protecting	protect	VBG
cord-005081-kxrzv16n	6	6	the	the	DT
cord-005081-kxrzv16n	6	7	population	population	NN
cord-005081-kxrzv16n	6	8	against	against	IN
cord-005081-kxrzv16n	6	9	influenza	influenza	NN
cord-005081-kxrzv16n	6	10	pandemics	pandemic	NNS
cord-005081-kxrzv16n	6	11	requires	require	VBZ
cord-005081-kxrzv16n	6	12	state	state	NN
cord-005081-kxrzv16n	6	13	-	-	HYPH
cord-005081-kxrzv16n	6	14	of	of	IN
cord-005081-kxrzv16n	6	15	-	-	HYPH
cord-005081-kxrzv16n	6	16	the	the	DT
cord-005081-kxrzv16n	6	17	-	-	HYPH
cord-005081-kxrzv16n	6	18	art	art	NN
cord-005081-kxrzv16n	6	19	approaches	approach	NNS
cord-005081-kxrzv16n	6	20	to	to	IN
cord-005081-kxrzv16n	6	21	the	the	DT
cord-005081-kxrzv16n	6	22	construction	construction	NN
cord-005081-kxrzv16n	6	23	of	of	IN
cord-005081-kxrzv16n	6	24	influenza	influenza	NN
cord-005081-kxrzv16n	6	25	vaccines	vaccine	NNS
cord-005081-kxrzv16n	6	26	to	to	TO
cord-005081-kxrzv16n	6	27	be	be	VB
cord-005081-kxrzv16n	6	28	based	base	VBN
cord-005081-kxrzv16n	6	29	on	on	IN
cord-005081-kxrzv16n	6	30	reassortment	reassortment	JJ
cord-005081-kxrzv16n	6	31	and	and	CC
cord-005081-kxrzv16n	6	32	genetic	genetic	JJ
cord-005081-kxrzv16n	6	33	engineering	engineering	NN
cord-005081-kxrzv16n	6	34	techniques	technique	NNS
cord-005081-kxrzv16n	6	35	,	,	,
cord-005081-kxrzv16n	6	36	including	include	VBG
cord-005081-kxrzv16n	6	37	the	the	DT
cord-005081-kxrzv16n	6	38	analysis	analysis	NN
cord-005081-kxrzv16n	6	39	of	of	IN
cord-005081-kxrzv16n	6	40	primary	primary	JJ
cord-005081-kxrzv16n	6	41	structures	structure	NNS
cord-005081-kxrzv16n	6	42	of	of	IN
cord-005081-kxrzv16n	6	43	influenza	influenza	JJ
cord-005081-kxrzv16n	6	44	viral	viral	JJ
cord-005081-kxrzv16n	6	45	genes	gene	NNS
cord-005081-kxrzv16n	6	46	,	,	,
cord-005081-kxrzv16n	6	47	synthesis	synthesis	NN
cord-005081-kxrzv16n	6	48	and	and	CC
cord-005081-kxrzv16n	6	49	cloning	cloning	NN
cord-005081-kxrzv16n	6	50	of	of	IN
cord-005081-kxrzv16n	6	51	the	the	DT
cord-005081-kxrzv16n	6	52	main	main	JJ
cord-005081-kxrzv16n	6	53	viral	viral	JJ
cord-005081-kxrzv16n	6	54	genes	gene	NNS
cord-005081-kxrzv16n	6	55	,	,	,
cord-005081-kxrzv16n	6	56	reverse	reverse	VB
cord-005081-kxrzv16n	6	57	genetics	genetics	NN
cord-005081-kxrzv16n	6	58	techniques	technique	NNS
cord-005081-kxrzv16n	6	59	,	,	,
cord-005081-kxrzv16n	6	60	and	and	CC
cord-005081-kxrzv16n	6	61	banks	bank	NNS
cord-005081-kxrzv16n	6	62	of	of	IN
cord-005081-kxrzv16n	6	63	plasmids	plasmid	NNS
cord-005081-kxrzv16n	6	64	bearing	bear	VBG
cord-005081-kxrzv16n	6	65	basic	basic	JJ
cord-005081-kxrzv16n	6	66	viral	viral	JJ
cord-005081-kxrzv16n	6	67	genes	gene	NNS
cord-005081-kxrzv16n	6	68	.	.	.
cord-005081-kxrzv16n	7	1	Reassortant	reassortant	JJ
cord-005081-kxrzv16n	7	2	technologies	technology	NNS
cord-005081-kxrzv16n	7	3	are	be	VBP
cord-005081-kxrzv16n	7	4	now	now	RB
cord-005081-kxrzv16n	7	5	giving	give	VBG
cord-005081-kxrzv16n	7	6	way	way	NN
cord-005081-kxrzv16n	7	7	to	to	IN
cord-005081-kxrzv16n	7	8	new	new	JJ
cord-005081-kxrzv16n	7	9	approaches	approach	NNS
cord-005081-kxrzv16n	7	10	for	for	IN
cord-005081-kxrzv16n	7	11	objective	objective	JJ
cord-005081-kxrzv16n	7	12	reasons	reason	NNS
cord-005081-kxrzv16n	7	13	.	.	.
cord-005081-kxrzv16n	8	1	The	the	DT
cord-005081-kxrzv16n	8	2	state	state	NN
cord-005081-kxrzv16n	8	3	-	-	HYPH
cord-005081-kxrzv16n	8	4	of	of	IN
cord-005081-kxrzv16n	8	5	-	-	HYPH
cord-005081-kxrzv16n	8	6	the	the	DT
cord-005081-kxrzv16n	8	7	-	-	HYPH
cord-005081-kxrzv16n	8	8	art	art	NN
cord-005081-kxrzv16n	8	9	technologies	technology	NNS
cord-005081-kxrzv16n	8	10	provide	provide	VBP
cord-005081-kxrzv16n	8	11	safety	safety	NN
cord-005081-kxrzv16n	8	12	not	not	RB
cord-005081-kxrzv16n	8	13	only	only	RB
cord-005081-kxrzv16n	8	14	at	at	IN
cord-005081-kxrzv16n	8	15	the	the	DT
cord-005081-kxrzv16n	8	16	laboratories	laboratory	NNS
cord-005081-kxrzv16n	8	17	where	where	WRB
cord-005081-kxrzv16n	8	18	vaccine	vaccine	NN
cord-005081-kxrzv16n	8	19	viruses	virus	NNS
cord-005081-kxrzv16n	8	20	are	be	VBP
cord-005081-kxrzv16n	8	21	constructed	construct	VBN
cord-005081-kxrzv16n	8	22	but	but	CC
cord-005081-kxrzv16n	8	23	also	also	RB
cord-005081-kxrzv16n	8	24	make	make	VB
cord-005081-kxrzv16n	8	25	the	the	DT
cord-005081-kxrzv16n	8	26	production	production	NN
cord-005081-kxrzv16n	8	27	process	process	NN
cord-005081-kxrzv16n	8	28	wholly	wholly	RB
cord-005081-kxrzv16n	8	29	safe	safe	JJ
cord-005081-kxrzv16n	8	30	.	.	.
cord-005081-kxrzv16n	9	1	We	-PRON-	PRP
cord-005081-kxrzv16n	9	2	are	be	VBP
cord-005081-kxrzv16n	9	3	using	use	VBG
cord-005081-kxrzv16n	9	4	the	the	DT
cord-005081-kxrzv16n	9	5	following	follow	VBG
cord-005081-kxrzv16n	9	6	approaches	approach	NNS
cord-005081-kxrzv16n	9	7	to	to	IN
cord-005081-kxrzv16n	9	8	the	the	DT
cord-005081-kxrzv16n	9	9	development	development	NN
cord-005081-kxrzv16n	9	10	of	of	IN
cord-005081-kxrzv16n	9	11	industrial	industrial	JJ
cord-005081-kxrzv16n	9	12	production	production	NN
cord-005081-kxrzv16n	9	13	:	:	:
cord-005081-kxrzv16n	9	14	use	use	NN
cord-005081-kxrzv16n	9	15	of	of	IN
cord-005081-kxrzv16n	9	16	nanoparticles	nanoparticle	NNS
cord-005081-kxrzv16n	9	17	and	and	CC
cord-005081-kxrzv16n	9	18	nanoemulsions	nanoemulsion	NNS
cord-005081-kxrzv16n	9	19	as	as	IN
cord-005081-kxrzv16n	9	20	functional	functional	JJ
cord-005081-kxrzv16n	9	21	adjuvants	adjuvant	NNS
cord-005081-kxrzv16n	9	22	,	,	,
cord-005081-kxrzv16n	9	23	construction	construction	NN
cord-005081-kxrzv16n	9	24	of	of	IN
cord-005081-kxrzv16n	9	25	totally	totally	RB
cord-005081-kxrzv16n	9	26	-	-	HYPH
cord-005081-kxrzv16n	9	27	safe	safe	JJ
cord-005081-kxrzv16n	9	28	strains	strain	NNS
cord-005081-kxrzv16n	9	29	for	for	IN
cord-005081-kxrzv16n	9	30	live	live	JJ
cord-005081-kxrzv16n	9	31	attenuated	attenuated	JJ
cord-005081-kxrzv16n	9	32	influenza	influenza	NN
cord-005081-kxrzv16n	9	33	vaccines	vaccine	NNS
cord-005081-kxrzv16n	9	34	with	with	IN
cord-005081-kxrzv16n	9	35	deletions	deletion	NNS
cord-005081-kxrzv16n	9	36	of	of	IN
cord-005081-kxrzv16n	9	37	molecular	molecular	JJ
cord-005081-kxrzv16n	9	38	determinants	determinant	NNS
cord-005081-kxrzv16n	9	39	of	of	IN
cord-005081-kxrzv16n	9	40	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	9	41	,	,	,
cord-005081-kxrzv16n	9	42	application	application	NN
cord-005081-kxrzv16n	9	43	of	of	IN
cord-005081-kxrzv16n	9	44	protein	protein	NN
cord-005081-kxrzv16n	9	45	and	and	CC
cord-005081-kxrzv16n	9	46	chemical	chemical	NN
cord-005081-kxrzv16n	9	47	chaperones	chaperone	NNS
cord-005081-kxrzv16n	9	48	to	to	TO
cord-005081-kxrzv16n	9	49	provide	provide	VB
cord-005081-kxrzv16n	9	50	self	self	NN
cord-005081-kxrzv16n	9	51	-	-	HYPH
cord-005081-kxrzv16n	9	52	assembly	assembly	NN
cord-005081-kxrzv16n	9	53	of	of	IN
cord-005081-kxrzv16n	9	54	haemagglutinin	haemagglutinin	NNP
cord-005081-kxrzv16n	9	55	molecules	molecule	NNS
cord-005081-kxrzv16n	9	56	of	of	IN
cord-005081-kxrzv16n	9	57	the	the	DT
cord-005081-kxrzv16n	9	58	H1N1v-2009	H1N1v-2009	NNP
cord-005081-kxrzv16n	9	59	virus	virus	NN
cord-005081-kxrzv16n	9	60	,	,	,
cord-005081-kxrzv16n	9	61	and	and	CC
cord-005081-kxrzv16n	9	62	impregnation	impregnation	NN
cord-005081-kxrzv16n	9	63	of	of	IN
cord-005081-kxrzv16n	9	64	whole	whole	JJ
cord-005081-kxrzv16n	9	65	-	-	HYPH
cord-005081-kxrzv16n	9	66	virion	virion	NN
cord-005081-kxrzv16n	9	67	preparations	preparation	NNS
cord-005081-kxrzv16n	9	68	with	with	IN
cord-005081-kxrzv16n	9	69	nanoparticles	nanoparticle	NNS
cord-005081-kxrzv16n	9	70	to	to	TO
cord-005081-kxrzv16n	9	71	enhance	enhance	VB
cord-005081-kxrzv16n	9	72	antigenicity	antigenicity	NN
cord-005081-kxrzv16n	9	73	.	.	.
cord-005081-kxrzv16n	10	1	The	the	DT
cord-005081-kxrzv16n	10	2	level	level	NN
cord-005081-kxrzv16n	10	3	of	of	IN
cord-005081-kxrzv16n	10	4	protection	protection	NN
cord-005081-kxrzv16n	10	5	against	against	IN
cord-005081-kxrzv16n	10	6	the	the	DT
cord-005081-kxrzv16n	10	7	avian	avian	JJ
cord-005081-kxrzv16n	10	8	flu	flu	NN
cord-005081-kxrzv16n	10	9	epi	epi	NNP
cord-005081-kxrzv16n	10	10	zootic	zootic	NNP
cord-005081-kxrzv16n	10	11	and	and	CC
cord-005081-kxrzv16n	10	12	the	the	DT
cord-005081-kxrzv16n	10	13	influenza	influenza	NN
cord-005081-kxrzv16n	10	14	pandemic	pandemic	NN
cord-005081-kxrzv16n	10	15	caused	cause	VBN
cord-005081-kxrzv16n	10	16	by	by	IN
cord-005081-kxrzv16n	10	17	the	the	DT
cord-005081-kxrzv16n	10	18	swine	swine	NN
cord-005081-kxrzv16n	10	19	lineage	lineage	NN
cord-005081-kxrzv16n	10	20	H1N1v	H1N1v	NNP
cord-005081-kxrzv16n	11	1	virus	virus	NN
cord-005081-kxrzv16n	11	2	can	can	MD
cord-005081-kxrzv16n	11	3	be	be	VB
cord-005081-kxrzv16n	11	4	characterized	characterize	VBN
cord-005081-kxrzv16n	11	5	as	as	IN
cord-005081-kxrzv16n	11	6	insufficient	insufficient	JJ
cord-005081-kxrzv16n	11	7	for	for	IN
cord-005081-kxrzv16n	11	8	Russia	Russia	NNP
cord-005081-kxrzv16n	11	9	's	's	POS
cord-005081-kxrzv16n	11	10	population	population	NN
cord-005081-kxrzv16n	11	11	.	.	.
cord-005081-kxrzv16n	12	1	The	the	DT
cord-005081-kxrzv16n	12	2	experience	experience	NN
cord-005081-kxrzv16n	12	3	in	in	IN
cord-005081-kxrzv16n	12	4	preventing	prevent	VBG
cord-005081-kxrzv16n	12	5	an	an	DT
cord-005081-kxrzv16n	12	6	outbreak	outbreak	NN
cord-005081-kxrzv16n	12	7	of	of	IN
cord-005081-kxrzv16n	12	8	SARS	SARS	NNP
cord-005081-kxrzv16n	12	9	in	in	IN
cord-005081-kxrzv16n	12	10	the	the	DT
cord-005081-kxrzv16n	12	11	territory	territory	NN
cord-005081-kxrzv16n	12	12	of	of	IN
cord-005081-kxrzv16n	12	13	Russia	Russia	NNP
cord-005081-kxrzv16n	12	14	has	have	VBZ
cord-005081-kxrzv16n	12	15	evidenced	evidence	VBN
cord-005081-kxrzv16n	12	16	that	that	IN
cord-005081-kxrzv16n	12	17	organized	organize	VBN
cord-005081-kxrzv16n	12	18	contraepidemic	contraepidemic	JJ
cord-005081-kxrzv16n	12	19	measures	measure	NNS
cord-005081-kxrzv16n	12	20	produce	produce	VBP
cord-005081-kxrzv16n	12	21	a	a	DT
cord-005081-kxrzv16n	12	22	temporary	temporary	JJ
cord-005081-kxrzv16n	12	23	,	,	,
cord-005081-kxrzv16n	12	24	albeit	albeit	IN
cord-005081-kxrzv16n	12	25	appreciable	appreciable	JJ
cord-005081-kxrzv16n	12	26	,	,	,
cord-005081-kxrzv16n	12	27	effect	effect	NN
cord-005081-kxrzv16n	12	28	.	.	.
cord-005081-kxrzv16n	13	1	The	the	DT
cord-005081-kxrzv16n	13	2	WHO	who	WP
cord-005081-kxrzv16n	13	3	recognizes	recognize	VBZ
cord-005081-kxrzv16n	13	4	the	the	DT
cord-005081-kxrzv16n	13	5	functional	functional	JJ
cord-005081-kxrzv16n	13	6	priority	priority	NN
cord-005081-kxrzv16n	13	7	of	of	IN
cord-005081-kxrzv16n	13	8	epidemiological	epidemiological	JJ
cord-005081-kxrzv16n	13	9	services	service	NNS
cord-005081-kxrzv16n	13	10	,	,	,
cord-005081-kxrzv16n	13	11	including	include	VBG
cord-005081-kxrzv16n	13	12	quarantine	quarantine	NN
cord-005081-kxrzv16n	13	13	mea	mea	FW
cord-005081-kxrzv16n	13	14	sures	sures	NNP
cord-005081-kxrzv16n	13	15	,	,	,
cord-005081-kxrzv16n	13	16	in	in	IN
cord-005081-kxrzv16n	13	17	localizing	localize	VBG
cord-005081-kxrzv16n	13	18	epicenters	epicenter	NNS
cord-005081-kxrzv16n	13	19	of	of	IN
cord-005081-kxrzv16n	13	20	infections	infection	NNS
cord-005081-kxrzv16n	13	21	and	and	CC
cord-005081-kxrzv16n	13	22	pre	pre	JJ
cord-005081-kxrzv16n	13	23	venting	vent	VBG
cord-005081-kxrzv16n	13	24	their	-PRON-	PRP$
cord-005081-kxrzv16n	13	25	cross	cross	NN
cord-005081-kxrzv16n	13	26	border	border	NN
cord-005081-kxrzv16n	13	27	spread	spread	NN
cord-005081-kxrzv16n	13	28	to	to	IN
cord-005081-kxrzv16n	13	29	other	other	JJ
cord-005081-kxrzv16n	13	30	countries	country	NNS
cord-005081-kxrzv16n	13	31	and	and	CC
cord-005081-kxrzv16n	13	32	continents	continent	NNS
cord-005081-kxrzv16n	13	33	,	,	,
cord-005081-kxrzv16n	13	34	that	that	RB
cord-005081-kxrzv16n	13	35	is	is	RB
cord-005081-kxrzv16n	13	36	,	,	,
cord-005081-kxrzv16n	13	37	the	the	DT
cord-005081-kxrzv16n	13	38	very	very	JJ
cord-005081-kxrzv16n	13	39	principles	principle	NNS
cord-005081-kxrzv16n	13	40	,	,	,
cord-005081-kxrzv16n	13	41	on	on	IN
cord-005081-kxrzv16n	13	42	which	which	WDT
cord-005081-kxrzv16n	13	43	the	the	DT
cord-005081-kxrzv16n	13	44	activities	activity	NNS
cord-005081-kxrzv16n	13	45	of	of	IN
cord-005081-kxrzv16n	13	46	public	public	JJ
cord-005081-kxrzv16n	13	47	health	health	NN
cord-005081-kxrzv16n	13	48	services	service	NNS
cord-005081-kxrzv16n	13	49	in	in	IN
cord-005081-kxrzv16n	13	50	our	-PRON-	PRP$
cord-005081-kxrzv16n	13	51	country	country	NN
cord-005081-kxrzv16n	13	52	have	have	VBP
cord-005081-kxrzv16n	13	53	always	always	RB
cord-005081-kxrzv16n	13	54	been	be	VBN
cord-005081-kxrzv16n	13	55	based	base	VBN
cord-005081-kxrzv16n	13	56	.	.	.
cord-005081-kxrzv16n	14	1	However	however	RB
cord-005081-kxrzv16n	14	2	,	,	,
cord-005081-kxrzv16n	14	3	the	the	DT
cord-005081-kxrzv16n	14	4	most	most	RBS
cord-005081-kxrzv16n	14	5	successful	successful	JJ
cord-005081-kxrzv16n	14	6	part	part	NN
cord-005081-kxrzv16n	14	7	of	of	IN
cord-005081-kxrzv16n	14	8	contraepidemic	contraepidemic	JJ
cord-005081-kxrzv16n	14	9	measures	measure	NNS
cord-005081-kxrzv16n	14	10	in	in	IN
cord-005081-kxrzv16n	14	11	preventing	prevent	VBG
cord-005081-kxrzv16n	14	12	the	the	DT
cord-005081-kxrzv16n	14	13	spread	spread	NN
cord-005081-kxrzv16n	14	14	of	of	IN
cord-005081-kxrzv16n	14	15	infections	infection	NNS
cord-005081-kxrzv16n	14	16	with	with	IN
cord-005081-kxrzv16n	14	17	respiratory	respiratory	JJ
cord-005081-kxrzv16n	14	18	transmission	transmission	NN
cord-005081-kxrzv16n	14	19	mechanism	mechanism	NN
cord-005081-kxrzv16n	14	20	is	be	VBZ
cord-005081-kxrzv16n	14	21	vaccinoprophylaxis	vaccinoprophylaxis	NNP
cord-005081-kxrzv16n	14	22	[	[	-LRB-
cord-005081-kxrzv16n	14	23	1	1	CD
cord-005081-kxrzv16n	14	24	,	,	,
cord-005081-kxrzv16n	14	25	2	2	CD
cord-005081-kxrzv16n	14	26	]	]	-RRB-
cord-005081-kxrzv16n	14	27	.	.	.
cord-005081-kxrzv16n	15	1	Supply	supply	NN
cord-005081-kxrzv16n	15	2	of	of	IN
cord-005081-kxrzv16n	15	3	vaccines	vaccine	NNS
cord-005081-kxrzv16n	15	4	critically	critically	RB
cord-005081-kxrzv16n	15	5	depends	depend	VBZ
cord-005081-kxrzv16n	15	6	on	on	IN
cord-005081-kxrzv16n	15	7	the	the	DT
cord-005081-kxrzv16n	15	8	level	level	NN
cord-005081-kxrzv16n	15	9	of	of	IN
cord-005081-kxrzv16n	15	10	technologies	technology	NNS
cord-005081-kxrzv16n	15	11	used	use	VBN
cord-005081-kxrzv16n	15	12	in	in	IN
cord-005081-kxrzv16n	15	13	the	the	DT
cord-005081-kxrzv16n	15	14	preparation	preparation	NN
cord-005081-kxrzv16n	15	15	of	of	IN
cord-005081-kxrzv16n	15	16	vaccine	vaccine	NN
cord-005081-kxrzv16n	15	17	strains	strain	NNS
cord-005081-kxrzv16n	15	18	and	and	CC
cord-005081-kxrzv16n	15	19	mass	mass	NN
cord-005081-kxrzv16n	15	20	production	production	NN
cord-005081-kxrzv16n	15	21	of	of	IN
cord-005081-kxrzv16n	15	22	vaccines	vaccine	NNS
cord-005081-kxrzv16n	15	23	.	.	.
cord-005081-kxrzv16n	16	1	The	the	DT
cord-005081-kxrzv16n	16	2	technologies	technology	NNS
cord-005081-kxrzv16n	16	3	now	now	RB
cord-005081-kxrzv16n	16	4	in	in	IN
cord-005081-kxrzv16n	16	5	use	use	NN
cord-005081-kxrzv16n	16	6	in	in	IN
cord-005081-kxrzv16n	16	7	Russia	Russia	NNP
cord-005081-kxrzv16n	16	8	and	and	CC
cord-005081-kxrzv16n	16	9	abroad	abroad	RB
cord-005081-kxrzv16n	16	10	are	be	VBP
cord-005081-kxrzv16n	16	11	those	those	DT
cord-005081-kxrzv16n	16	12	developed	develop	VBN
cord-005081-kxrzv16n	16	13	more	more	JJR
cord-005081-kxrzv16n	16	14	than	than	IN
cord-005081-kxrzv16n	16	15	15	15	CD
cord-005081-kxrzv16n	16	16	years	year	NNS
cord-005081-kxrzv16n	16	17	ago	ago	RB
cord-005081-kxrzv16n	16	18	.	.	.
cord-005081-kxrzv16n	17	1	However	however	RB
cord-005081-kxrzv16n	17	2	,	,	,
cord-005081-kxrzv16n	17	3	this	this	DT
cord-005081-kxrzv16n	17	4	sphere	sphere	NN
cord-005081-kxrzv16n	17	5	has	have	VBZ
cord-005081-kxrzv16n	17	6	made	make	VBN
cord-005081-kxrzv16n	17	7	significant	significant	JJ
cord-005081-kxrzv16n	17	8	progress	progress	NN
cord-005081-kxrzv16n	17	9	over	over	IN
cord-005081-kxrzv16n	17	10	the	the	DT
cord-005081-kxrzv16n	17	11	last	last	JJ
cord-005081-kxrzv16n	17	12	5	5	CD
cord-005081-kxrzv16n	17	13	years	year	NNS
cord-005081-kxrzv16n	17	14	.	.	.
cord-005081-kxrzv16n	18	1	The	the	DT
cord-005081-kxrzv16n	18	2	prepared	prepared	JJ
cord-005081-kxrzv16n	18	3	ness	ness	NN
cord-005081-kxrzv16n	18	4	activities	activity	NNS
cord-005081-kxrzv16n	18	5	related	relate	VBN
cord-005081-kxrzv16n	18	6	to	to	IN
cord-005081-kxrzv16n	18	7	the	the	DT
cord-005081-kxrzv16n	18	8	influenza	influenza	NN
cord-005081-kxrzv16n	18	9	pandemic	pandemic	NN
cord-005081-kxrzv16n	18	10	and	and	CC
cord-005081-kxrzv16n	18	11	its	-PRON-	PRP$
cord-005081-kxrzv16n	18	12	global	global	JJ
cord-005081-kxrzv16n	18	13	outbreak	outbreak	NN
cord-005081-kxrzv16n	18	14	in	in	IN
cord-005081-kxrzv16n	18	15	2009	2009	CD
cord-005081-kxrzv16n	18	16	substantially	substantially	RB
cord-005081-kxrzv16n	18	17	increased	increase	VBD
cord-005081-kxrzv16n	18	18	the	the	DT
cord-005081-kxrzv16n	18	19	demand	demand	NN
cord-005081-kxrzv16n	18	20	for	for	IN
cord-005081-kxrzv16n	18	21	vaccines	vaccine	NNS
cord-005081-kxrzv16n	18	22	.	.	.
cord-005081-kxrzv16n	19	1	According	accord	VBG
cord-005081-kxrzv16n	19	2	to	to	IN
cord-005081-kxrzv16n	19	3	WHO	who	WP
cord-005081-kxrzv16n	19	4	's	's	POS
cord-005081-kxrzv16n	19	5	estimate	estimate	NN
cord-005081-kxrzv16n	19	6	,	,	,
cord-005081-kxrzv16n	19	7	the	the	DT
cord-005081-kxrzv16n	19	8	annual	annual	JJ
cord-005081-kxrzv16n	19	9	global	global	JJ
cord-005081-kxrzv16n	19	10	demand	demand	NN
cord-005081-kxrzv16n	19	11	accounts	account	VBZ
cord-005081-kxrzv16n	19	12	for	for	IN
cord-005081-kxrzv16n	19	13	2	2	CD
cord-005081-kxrzv16n	19	14	to	to	TO
cord-005081-kxrzv16n	19	15	3	3	CD
cord-005081-kxrzv16n	19	16	billion	billion	CD
cord-005081-kxrzv16n	19	17	doses	dose	NNS
cord-005081-kxrzv16n	19	18	.	.	.
cord-005081-kxrzv16n	20	1	Russia	Russia	NNP
cord-005081-kxrzv16n	20	2	's	's	POS
cord-005081-kxrzv16n	20	3	influenza	influenza	NN
cord-005081-kxrzv16n	20	4	vaccine	vaccine	NN
cord-005081-kxrzv16n	20	5	production	production	NN
cord-005081-kxrzv16n	20	6	potential	potential	NN
cord-005081-kxrzv16n	20	7	is	be	VBZ
cord-005081-kxrzv16n	20	8	higher	high	JJR
cord-005081-kxrzv16n	20	9	than	than	IN
cord-005081-kxrzv16n	20	10	in	in	IN
cord-005081-kxrzv16n	20	11	other	other	JJ
cord-005081-kxrzv16n	20	12	countries	country	NNS
cord-005081-kxrzv16n	20	13	and	and	CC
cord-005081-kxrzv16n	20	14	sufficient	sufficient	JJ
cord-005081-kxrzv16n	20	15	for	for	IN
cord-005081-kxrzv16n	20	16	con	con	FW
cord-005081-kxrzv16n	20	17	ducting	ducting	NN
cord-005081-kxrzv16n	20	18	annual	annual	JJ
cord-005081-kxrzv16n	20	19	vaccinations	vaccination	NNS
cord-005081-kxrzv16n	20	20	in	in	IN
cord-005081-kxrzv16n	20	21	more	more	JJR
cord-005081-kxrzv16n	20	22	than	than	IN
cord-005081-kxrzv16n	20	23	50	50	CD
cord-005081-kxrzv16n	20	24	%	%	NN
cord-005081-kxrzv16n	20	25	of	of	IN
cord-005081-kxrzv16n	20	26	the	the	DT
cord-005081-kxrzv16n	20	27	population	population	NN
cord-005081-kxrzv16n	20	28	.	.	.
cord-005081-kxrzv16n	21	1	At	at	IN
cord-005081-kxrzv16n	21	2	the	the	DT
cord-005081-kxrzv16n	21	3	same	same	JJ
cord-005081-kxrzv16n	21	4	time	time	NN
cord-005081-kxrzv16n	21	5	,	,	,
cord-005081-kxrzv16n	21	6	the	the	DT
cord-005081-kxrzv16n	21	7	problems	problem	NNS
cord-005081-kxrzv16n	21	8	associated	associate	VBN
cord-005081-kxrzv16n	21	9	with	with	IN
cord-005081-kxrzv16n	21	10	the	the	DT
cord-005081-kxrzv16n	21	11	supply	supply	NN
cord-005081-kxrzv16n	21	12	and	and	CC
cord-005081-kxrzv16n	21	13	quality	quality	NN
cord-005081-kxrzv16n	21	14	of	of	IN
cord-005081-kxrzv16n	21	15	influenza	influenza	NN
cord-005081-kxrzv16n	21	16	vaccines	vaccine	NNS
cord-005081-kxrzv16n	21	17	remain	remain	VBP
cord-005081-kxrzv16n	21	18	the	the	DT
cord-005081-kxrzv16n	21	19	most	most	RBS
cord-005081-kxrzv16n	21	20	important	important	JJ
cord-005081-kxrzv16n	21	21	for	for	IN
cord-005081-kxrzv16n	21	22	Russia	Russia	NNP
cord-005081-kxrzv16n	21	23	and	and	CC
cord-005081-kxrzv16n	21	24	the	the	DT
cord-005081-kxrzv16n	21	25	rest	rest	NN
cord-005081-kxrzv16n	21	26	of	of	IN
cord-005081-kxrzv16n	21	27	the	the	DT
cord-005081-kxrzv16n	21	28	world	world	NN
cord-005081-kxrzv16n	21	29	and	and	CC
cord-005081-kxrzv16n	21	30	strongly	strongly	RB
cord-005081-kxrzv16n	21	31	depend	depend	VB
cord-005081-kxrzv16n	21	32	on	on	IN
cord-005081-kxrzv16n	21	33	the	the	DT
cord-005081-kxrzv16n	21	34	promptness	promptness	NN
cord-005081-kxrzv16n	21	35	with	with	IN
cord-005081-kxrzv16n	21	36	which	which	WDT
cord-005081-kxrzv16n	21	37	new	new	JJ
cord-005081-kxrzv16n	21	38	technologies	technology	NNS
cord-005081-kxrzv16n	21	39	are	be	VBP
cord-005081-kxrzv16n	21	40	adopted	adopt	VBN
cord-005081-kxrzv16n	21	41	.	.	.
cord-005081-kxrzv16n	22	1	Vaccination	vaccination	NN
cord-005081-kxrzv16n	22	2	is	be	VBZ
cord-005081-kxrzv16n	22	3	an	an	DT
cord-005081-kxrzv16n	22	4	important	important	JJ
cord-005081-kxrzv16n	22	5	part	part	NN
cord-005081-kxrzv16n	22	6	in	in	IN
cord-005081-kxrzv16n	22	7	the	the	DT
cord-005081-kxrzv16n	22	8	complex	complex	NN
cord-005081-kxrzv16n	22	9	of	of	IN
cord-005081-kxrzv16n	22	10	contraactions	contraaction	NNS
cord-005081-kxrzv16n	22	11	organized	organize	VBN
cord-005081-kxrzv16n	22	12	by	by	IN
cord-005081-kxrzv16n	22	13	public	public	JJ
cord-005081-kxrzv16n	22	14	health	health	NN
cord-005081-kxrzv16n	22	15	services	service	NNS
cord-005081-kxrzv16n	22	16	against	against	IN
cord-005081-kxrzv16n	22	17	influenza	influenza	NN
cord-005081-kxrzv16n	22	18	pandemics	pandemic	NNS
cord-005081-kxrzv16n	22	19	.	.	.
cord-005081-kxrzv16n	23	1	Like	like	IN
cord-005081-kxrzv16n	23	2	the	the	DT
cord-005081-kxrzv16n	23	3	Soviet	Soviet	NNP
cord-005081-kxrzv16n	23	4	Union	Union	NNP
cord-005081-kxrzv16n	23	5	used	use	VBD
cord-005081-kxrzv16n	23	6	to	to	TO
cord-005081-kxrzv16n	23	7	be	be	VB
cord-005081-kxrzv16n	23	8	,	,	,
cord-005081-kxrzv16n	23	9	the	the	DT
cord-005081-kxrzv16n	23	10	Russian	Russian	NNP
cord-005081-kxrzv16n	23	11	Federation	Federation	NNP
cord-005081-kxrzv16n	23	12	remains	remain	VBZ
cord-005081-kxrzv16n	23	13	a	a	DT
cord-005081-kxrzv16n	23	14	leader	leader	NN
cord-005081-kxrzv16n	23	15	in	in	IN
cord-005081-kxrzv16n	23	16	conducting	conduct	VBG
cord-005081-kxrzv16n	23	17	mass	mass	JJ
cord-005081-kxrzv16n	23	18	prophylactic	prophylactic	JJ
cord-005081-kxrzv16n	23	19	immunizations	immunization	NNS
cord-005081-kxrzv16n	23	20	,	,	,
cord-005081-kxrzv16n	23	21	in	in	IN
cord-005081-kxrzv16n	23	22	par	par	FW
cord-005081-kxrzv16n	23	23	ticular	ticular	NNP
cord-005081-kxrzv16n	23	24	,	,	,
cord-005081-kxrzv16n	23	25	antiinfluenza	antiinfluenza	NNP
cord-005081-kxrzv16n	23	26	vaccinations	vaccination	NNS
cord-005081-kxrzv16n	23	27	.	.	.
cord-005081-kxrzv16n	24	1	This	this	DT
cord-005081-kxrzv16n	24	2	must	must	MD
cord-005081-kxrzv16n	24	3	be	be	VB
cord-005081-kxrzv16n	24	4	marked	mark	VBN
cord-005081-kxrzv16n	24	5	as	as	IN
cord-005081-kxrzv16n	24	6	one	one	CD
cord-005081-kxrzv16n	24	7	of	of	IN
cord-005081-kxrzv16n	24	8	the	the	DT
cord-005081-kxrzv16n	24	9	most	most	RBS
cord-005081-kxrzv16n	24	10	important	important	JJ
cord-005081-kxrzv16n	24	11	achievements	achievement	NNS
cord-005081-kxrzv16n	24	12	of	of	IN
cord-005081-kxrzv16n	24	13	the	the	DT
cord-005081-kxrzv16n	24	14	past	past	NN
cord-005081-kxrzv16n	24	15	.	.	.
cord-005081-kxrzv16n	25	1	The	the	DT
cord-005081-kxrzv16n	25	2	country	country	NN
cord-005081-kxrzv16n	25	3	's	's	POS
cord-005081-kxrzv16n	25	4	complex	complex	NN
cord-005081-kxrzv16n	25	5	of	of	IN
cord-005081-kxrzv16n	25	6	vaccine	vaccine	NN
cord-005081-kxrzv16n	25	7	producers	producer	NNS
cord-005081-kxrzv16n	25	8	has	have	VBZ
cord-005081-kxrzv16n	25	9	demonstrated	demonstrate	VBN
cord-005081-kxrzv16n	25	10	increased	increase	VBN
cord-005081-kxrzv16n	25	11	growth	growth	NN
cord-005081-kxrzv16n	25	12	rates	rate	NNS
cord-005081-kxrzv16n	25	13	in	in	IN
cord-005081-kxrzv16n	25	14	recent	recent	JJ
cord-005081-kxrzv16n	25	15	years	year	NNS
cord-005081-kxrzv16n	25	16	against	against	IN
cord-005081-kxrzv16n	25	17	the	the	DT
cord-005081-kxrzv16n	25	18	difficult	difficult	JJ
cord-005081-kxrzv16n	25	19	situation	situation	NN
cord-005081-kxrzv16n	25	20	in	in	IN
cord-005081-kxrzv16n	25	21	the	the	DT
cord-005081-kxrzv16n	25	22	pharmaceu	pharmaceu	NNP
cord-005081-kxrzv16n	25	23	tical	tical	NNP
cord-005081-kxrzv16n	25	24	industry	industry	NN
cord-005081-kxrzv16n	25	25	.	.	.
cord-005081-kxrzv16n	26	1	Despite	despite	IN
cord-005081-kxrzv16n	26	2	certain	certain	JJ
cord-005081-kxrzv16n	26	3	technological	technological	JJ
cord-005081-kxrzv16n	26	4	lagging	lagging	NN
cord-005081-kxrzv16n	26	5	,	,	,
cord-005081-kxrzv16n	26	6	our	-PRON-	PRP$
cord-005081-kxrzv16n	26	7	country	country	NN
cord-005081-kxrzv16n	26	8	remains	remain	VBZ
cord-005081-kxrzv16n	26	9	a	a	DT
cord-005081-kxrzv16n	26	10	leading	lead	VBG
cord-005081-kxrzv16n	26	11	producer	producer	NN
cord-005081-kxrzv16n	26	12	of	of	IN
cord-005081-kxrzv16n	26	13	practically	practically	RB
cord-005081-kxrzv16n	26	14	a	a	DT
cord-005081-kxrzv16n	26	15	whole	whole	JJ
cord-005081-kxrzv16n	26	16	spectrum	spectrum	NN
cord-005081-kxrzv16n	26	17	of	of	IN
cord-005081-kxrzv16n	26	18	important	important	JJ
cord-005081-kxrzv16n	26	19	vaccines	vaccine	NNS
cord-005081-kxrzv16n	26	20	in	in	IN
cord-005081-kxrzv16n	26	21	the	the	DT
cord-005081-kxrzv16n	26	22	world	world	NN
cord-005081-kxrzv16n	26	23	's	's	POS
cord-005081-kxrzv16n	26	24	sector	sector	NN
cord-005081-kxrzv16n	26	25	of	of	IN
cord-005081-kxrzv16n	26	26	this	this	DT
cord-005081-kxrzv16n	26	27	industry	industry	NN
cord-005081-kxrzv16n	26	28	.	.	.
cord-005081-kxrzv16n	27	1	In	in	IN
cord-005081-kxrzv16n	27	2	fact	fact	NN
cord-005081-kxrzv16n	27	3	,	,	,
cord-005081-kxrzv16n	27	4	from	from	IN
cord-005081-kxrzv16n	27	5	the	the	DT
cord-005081-kxrzv16n	27	6	late	late	JJ
cord-005081-kxrzv16n	27	7	1960s	1960	NNS
cord-005081-kxrzv16n	27	8	up	up	IN
cord-005081-kxrzv16n	27	9	to	to	IN
cord-005081-kxrzv16n	27	10	the	the	DT
cord-005081-kxrzv16n	27	11	late	late	JJ
cord-005081-kxrzv16n	27	12	1980s	1980	NNS
cord-005081-kxrzv16n	27	13	,	,	,
cord-005081-kxrzv16n	27	14	all	all	DT
cord-005081-kxrzv16n	27	15	contemporary	contemporary	JJ
cord-005081-kxrzv16n	27	16	influenza	influenza	NN
cord-005081-kxrzv16n	27	17	vaccines	vaccine	NNS
cord-005081-kxrzv16n	27	18	were	be	VBD
cord-005081-kxrzv16n	27	19	pioneered	pioneer	VBN
cord-005081-kxrzv16n	27	20	in	in	IN
cord-005081-kxrzv16n	27	21	the	the	DT
cord-005081-kxrzv16n	27	22	Soviet	Soviet	NNP
cord-005081-kxrzv16n	27	23	Union	Union	NNP
cord-005081-kxrzv16n	27	24	.	.	.
cord-005081-kxrzv16n	28	1	Then	then	RB
cord-005081-kxrzv16n	28	2	basic	basic	JJ
cord-005081-kxrzv16n	28	3	tech	tech	NN
cord-005081-kxrzv16n	28	4	nologies	nologie	NNS
cord-005081-kxrzv16n	28	5	used	use	VBN
cord-005081-kxrzv16n	28	6	to	to	TO
cord-005081-kxrzv16n	28	7	spread	spread	VB
cord-005081-kxrzv16n	28	8	globally	globally	RB
cord-005081-kxrzv16n	28	9	[	[	-LRB-
cord-005081-kxrzv16n	28	10	1	1	CD
cord-005081-kxrzv16n	28	11	]	]	-RRB-
cord-005081-kxrzv16n	28	12	[	[	-LRB-
cord-005081-kxrzv16n	28	13	2	2	CD
cord-005081-kxrzv16n	28	14	]	]	-RRB-
cord-005081-kxrzv16n	28	15	[	[	-LRB-
cord-005081-kxrzv16n	28	16	3	3	CD
cord-005081-kxrzv16n	28	17	]	]	-RRB-
cord-005081-kxrzv16n	29	1	[	[	-LRB-
cord-005081-kxrzv16n	29	2	4	4	CD
cord-005081-kxrzv16n	29	3	]	]	-RRB-
cord-005081-kxrzv16n	29	4	[	[	-LRB-
cord-005081-kxrzv16n	29	5	5	5	CD
cord-005081-kxrzv16n	29	6	]	]	-RRB-
cord-005081-kxrzv16n	29	7	[	[	-LRB-
cord-005081-kxrzv16n	29	8	6	6	CD
cord-005081-kxrzv16n	29	9	]	]	-RRB-
cord-005081-kxrzv16n	29	10	[	[	-LRB-
cord-005081-kxrzv16n	29	11	7	7	CD
cord-005081-kxrzv16n	29	12	]	]	-RRB-
cord-005081-kxrzv16n	29	13	.	.	.
cord-005081-kxrzv16n	30	1	The	the	DT
cord-005081-kxrzv16n	30	2	initial	initial	JJ
cord-005081-kxrzv16n	30	3	impulse	impulse	NN
cord-005081-kxrzv16n	30	4	for	for	IN
cord-005081-kxrzv16n	30	5	scaling	scale	VBG
cord-005081-kxrzv16n	30	6	up	up	RP
cord-005081-kxrzv16n	30	7	the	the	DT
cord-005081-kxrzv16n	30	8	industrial	industrial	JJ
cord-005081-kxrzv16n	30	9	supply	supply	NN
cord-005081-kxrzv16n	30	10	came	come	VBD
cord-005081-kxrzv16n	30	11	with	with	IN
cord-005081-kxrzv16n	30	12	the	the	DT
cord-005081-kxrzv16n	30	13	Hong	Hong	NNP
cord-005081-kxrzv16n	30	14	Kong	Kong	NNP
cord-005081-kxrzv16n	30	15	influenza	influenza	NN
cord-005081-kxrzv16n	30	16	pandemic	pandemic	NN
cord-005081-kxrzv16n	30	17	of	of	IN
cord-005081-kxrzv16n	30	18	1968	1968	CD
cord-005081-kxrzv16n	30	19	[	[	-LRB-
cord-005081-kxrzv16n	30	20	5	5	CD
cord-005081-kxrzv16n	30	21	]	]	-RRB-
cord-005081-kxrzv16n	30	22	[	[	-LRB-
cord-005081-kxrzv16n	30	23	6	6	CD
cord-005081-kxrzv16n	30	24	]	]	-RRB-
cord-005081-kxrzv16n	30	25	[	[	-LRB-
cord-005081-kxrzv16n	30	26	7	7	CD
cord-005081-kxrzv16n	30	27	]	]	-RRB-
cord-005081-kxrzv16n	30	28	[	[	-LRB-
cord-005081-kxrzv16n	30	29	8	8	CD
cord-005081-kxrzv16n	30	30	]	]	-RRB-
cord-005081-kxrzv16n	30	31	.	.	.
cord-005081-kxrzv16n	31	1	The	the	DT
cord-005081-kxrzv16n	31	2	avian	avian	JJ
cord-005081-kxrzv16n	31	3	flu	flu	NN
cord-005081-kxrzv16n	31	4	epidemic	epidemic	NN
cord-005081-kxrzv16n	31	5	also	also	RB
cord-005081-kxrzv16n	31	6	brought	bring	VBD
cord-005081-kxrzv16n	31	7	a	a	DT
cord-005081-kxrzv16n	31	8	serious	serious	JJ
cord-005081-kxrzv16n	31	9	challenge	challenge	NN
cord-005081-kxrzv16n	31	10	to	to	IN
cord-005081-kxrzv16n	31	11	the	the	DT
cord-005081-kxrzv16n	31	12	world	world	NN
cord-005081-kxrzv16n	31	13	community	community	NN
cord-005081-kxrzv16n	31	14	,	,	,
cord-005081-kxrzv16n	31	15	but	but	CC
cord-005081-kxrzv16n	31	16	that	that	DT
cord-005081-kxrzv16n	31	17	was	be	VBD
cord-005081-kxrzv16n	31	18	already	already	RB
cord-005081-kxrzv16n	31	19	the	the	DT
cord-005081-kxrzv16n	31	20	period	period	NN
cord-005081-kxrzv16n	31	21	when	when	WRB
cord-005081-kxrzv16n	31	22	a	a	DT
cord-005081-kxrzv16n	31	23	necessity	necessity	NN
cord-005081-kxrzv16n	31	24	to	to	TO
cord-005081-kxrzv16n	31	25	employ	employ	VB
cord-005081-kxrzv16n	31	26	novel	novel	JJ
cord-005081-kxrzv16n	31	27	biotechnological	biotechnological	JJ
cord-005081-kxrzv16n	31	28	achievements	achievement	NNS
cord-005081-kxrzv16n	31	29	in	in	IN
cord-005081-kxrzv16n	31	30	influenza	influenza	NN
cord-005081-kxrzv16n	31	31	vaccine	vaccine	NN
cord-005081-kxrzv16n	31	32	production	production	NN
cord-005081-kxrzv16n	31	33	was	be	VBD
cord-005081-kxrzv16n	31	34	realized	realize	VBN
cord-005081-kxrzv16n	31	35	[	[	-LRB-
cord-005081-kxrzv16n	31	36	1	1	CD
cord-005081-kxrzv16n	31	37	]	]	-RRB-
cord-005081-kxrzv16n	31	38	.	.	.
cord-005081-kxrzv16n	32	1	Medical	medical	JJ
cord-005081-kxrzv16n	32	2	services	service	NNS
cord-005081-kxrzv16n	32	3	have	have	VBP
cord-005081-kxrzv16n	32	4	acquired	acquire	VBN
cord-005081-kxrzv16n	32	5	much	much	JJ
cord-005081-kxrzv16n	32	6	experience	experience	NN
cord-005081-kxrzv16n	32	7	in	in	IN
cord-005081-kxrzv16n	32	8	the	the	DT
cord-005081-kxrzv16n	32	9	application	application	NN
cord-005081-kxrzv16n	32	10	of	of	IN
cord-005081-kxrzv16n	32	11	influenza	influenza	NN
cord-005081-kxrzv16n	32	12	vaccines	vaccine	NNS
cord-005081-kxrzv16n	32	13	.	.	.
cord-005081-kxrzv16n	33	1	In	in	IN
cord-005081-kxrzv16n	33	2	the	the	DT
cord-005081-kxrzv16n	33	3	Russian	Russian	NNP
cord-005081-kxrzv16n	33	4	Federation	Federation	NNP
cord-005081-kxrzv16n	33	5	,	,	,
cord-005081-kxrzv16n	33	6	the	the	DT
cord-005081-kxrzv16n	33	7	population	population	NN
cord-005081-kxrzv16n	33	8	has	have	VBZ
cord-005081-kxrzv16n	33	9	already	already	RB
cord-005081-kxrzv16n	33	10	been	be	VBN
cord-005081-kxrzv16n	33	11	vacci	vacci	NNP
cord-005081-kxrzv16n	33	12	nated	nate	VBN
cord-005081-kxrzv16n	33	13	using	use	VBG
cord-005081-kxrzv16n	33	14	seasonal	seasonal	JJ
cord-005081-kxrzv16n	33	15	influenza	influenza	NN
cord-005081-kxrzv16n	33	16	trivalent	trivalent	JJ
cord-005081-kxrzv16n	33	17	and	and	CC
cord-005081-kxrzv16n	33	18	monova	monova	NNP
cord-005081-kxrzv16n	33	19	lent	lend	VBD
cord-005081-kxrzv16n	33	20	vaccines	vaccine	NNS
cord-005081-kxrzv16n	33	21	against	against	IN
cord-005081-kxrzv16n	33	22	the	the	DT
cord-005081-kxrzv16n	33	23	pandemic	pandemic	NN
cord-005081-kxrzv16n	33	24	H1N1v	h1n1v	CD
cord-005081-kxrzv16n	33	25	2009	2009	CD
cord-005081-kxrzv16n	33	26	virus	virus	NN
cord-005081-kxrzv16n	33	27	.	.	.
cord-005081-kxrzv16n	34	1	In	in	IN
cord-005081-kxrzv16n	34	2	Russia	Russia	NNP
cord-005081-kxrzv16n	34	3	and	and	CC
cord-005081-kxrzv16n	34	4	globally	globally	RB
cord-005081-kxrzv16n	34	5	,	,	,
cord-005081-kxrzv16n	34	6	two	two	CD
cord-005081-kxrzv16n	34	7	basic	basic	JJ
cord-005081-kxrzv16n	34	8	types	type	NNS
cord-005081-kxrzv16n	34	9	of	of	IN
cord-005081-kxrzv16n	34	10	vaccines	vaccine	NNS
cord-005081-kxrzv16n	34	11	are	be	VBP
cord-005081-kxrzv16n	34	12	used	use	VBN
cord-005081-kxrzv16n	34	13	for	for	IN
cord-005081-kxrzv16n	34	14	prophylaxis	prophylaxis	NN
cord-005081-kxrzv16n	34	15	[	[	-LRB-
cord-005081-kxrzv16n	34	16	8	8	CD
cord-005081-kxrzv16n	34	17	]	]	-RRB-
cord-005081-kxrzv16n	35	1	[	[	-LRB-
cord-005081-kxrzv16n	35	2	9	9	CD
cord-005081-kxrzv16n	35	3	]	]	-RRB-
cord-005081-kxrzv16n	35	4	[	[	-LRB-
cord-005081-kxrzv16n	35	5	10	10	CD
cord-005081-kxrzv16n	35	6	]	]	-RRB-
cord-005081-kxrzv16n	35	7	[	[	-LRB-
cord-005081-kxrzv16n	35	8	11	11	CD
cord-005081-kxrzv16n	35	9	]	]	-RRB-
cord-005081-kxrzv16n	35	10	[	[	-LRB-
cord-005081-kxrzv16n	35	11	12	12	CD
cord-005081-kxrzv16n	35	12	]	]	-RRB-
cord-005081-kxrzv16n	35	13	[	[	-LRB-
cord-005081-kxrzv16n	35	14	13	13	CD
cord-005081-kxrzv16n	35	15	]	]	-RRB-
cord-005081-kxrzv16n	35	16	:	:	:
cord-005081-kxrzv16n	35	17	inactivated	inactivate	VBN
cord-005081-kxrzv16n	35	18	influenza	influenza	NN
cord-005081-kxrzv16n	35	19	vaccines	vaccine	NNS
cord-005081-kxrzv16n	35	20	and	and	CC
cord-005081-kxrzv16n	35	21	live	live	VBP
cord-005081-kxrzv16n	35	22	attenuated	attenuated	JJ
cord-005081-kxrzv16n	35	23	influenza	influenza	NN
cord-005081-kxrzv16n	35	24	vaccines	vaccine	NNS
cord-005081-kxrzv16n	35	25	.	.	.
cord-005081-kxrzv16n	36	1	The	the	DT
cord-005081-kxrzv16n	36	2	main	main	JJ
cord-005081-kxrzv16n	36	3	types	type	NNS
cord-005081-kxrzv16n	36	4	of	of	IN
cord-005081-kxrzv16n	36	5	vaccine	vaccine	NN
cord-005081-kxrzv16n	36	6	preparations	preparation	NNS
cord-005081-kxrzv16n	36	7	with	with	IN
cord-005081-kxrzv16n	36	8	their	-PRON-	PRP$
cord-005081-kxrzv16n	36	9	properties	property	NNS
cord-005081-kxrzv16n	36	10	and	and	CC
cord-005081-kxrzv16n	36	11	compositions	composition	NNS
cord-005081-kxrzv16n	36	12	are	be	VBP
cord-005081-kxrzv16n	36	13	given	give	VBN
cord-005081-kxrzv16n	36	14	in	in	IN
cord-005081-kxrzv16n	36	15	Fig	Fig	NNP
cord-005081-kxrzv16n	36	16	.	.	.
cord-005081-kxrzv16n	37	1	1	1	LS
cord-005081-kxrzv16n	37	2	(	(	-LRB-
cord-005081-kxrzv16n	37	3	on	on	IN
cord-005081-kxrzv16n	37	4	the	the	DT
cord-005081-kxrzv16n	37	5	colored	colored	JJ
cord-005081-kxrzv16n	37	6	inset	inset	NN
cord-005081-kxrzv16n	37	7	)	)	-RRB-
cord-005081-kxrzv16n	37	8	.	.	.
cord-005081-kxrzv16n	38	1	We	-PRON-	PRP
cord-005081-kxrzv16n	38	2	give	give	VBP
cord-005081-kxrzv16n	38	3	also	also	RB
cord-005081-kxrzv16n	38	4	novel	novel	JJ
cord-005081-kxrzv16n	38	5	types	type	NNS
cord-005081-kxrzv16n	38	6	of	of	IN
cord-005081-kxrzv16n	38	7	vaccines	vaccine	NNS
cord-005081-kxrzv16n	39	1	;	;	:
cord-005081-kxrzv16n	39	2	their	-PRON-	PRP$
cord-005081-kxrzv16n	39	3	properties	property	NNS
cord-005081-kxrzv16n	39	4	and	and	CC
cord-005081-kxrzv16n	39	5	technology	technology	NN
cord-005081-kxrzv16n	39	6	are	be	VBP
cord-005081-kxrzv16n	39	7	described	describe	VBN
cord-005081-kxrzv16n	39	8	below	below	IN
cord-005081-kxrzv16n	39	9	;	;	:
cord-005081-kxrzv16n	39	10	generation	generation	NN
cord-005081-kxrzv16n	39	11	IV	IV	NNP
cord-005081-kxrzv16n	39	12	represents	represent	VBZ
cord-005081-kxrzv16n	39	13	the	the	DT
cord-005081-kxrzv16n	39	14	contribution	contribution	NN
cord-005081-kxrzv16n	39	15	made	make	VBN
cord-005081-kxrzv16n	39	16	by	by	IN
cord-005081-kxrzv16n	39	17	nanotechnologies	nanotechnology	NNS
cord-005081-kxrzv16n	39	18	playing	play	VBG
cord-005081-kxrzv16n	39	19	a	a	DT
cord-005081-kxrzv16n	39	20	principal	principal	JJ
cord-005081-kxrzv16n	39	21	role	role	NN
cord-005081-kxrzv16n	39	22	in	in	IN
cord-005081-kxrzv16n	39	23	revolu	revolu	NNP
cord-005081-kxrzv16n	39	24	tionized	tionize	VBN
cord-005081-kxrzv16n	39	25	vaccine	vaccine	NN
cord-005081-kxrzv16n	39	26	production	production	NN
cord-005081-kxrzv16n	39	27	development	development	NN
cord-005081-kxrzv16n	39	28	.	.	.
cord-005081-kxrzv16n	40	1	Inactivated	inactivate	VBN
cord-005081-kxrzv16n	40	2	influenza	influenza	NN
cord-005081-kxrzv16n	40	3	vaccines	vaccine	NNS
cord-005081-kxrzv16n	40	4	contain	contain	VBP
cord-005081-kxrzv16n	40	5	influenza	influenza	NN
cord-005081-kxrzv16n	40	6	virus	virus	NN
cord-005081-kxrzv16n	40	7	strains	strain	NNS
cord-005081-kxrzv16n	40	8	preliminarily	preliminarily	RB
cord-005081-kxrzv16n	40	9	subjected	subject	VBN
cord-005081-kxrzv16n	40	10	to	to	IN
cord-005081-kxrzv16n	40	11	UV	UV	NNP
cord-005081-kxrzv16n	40	12	and	and	CC
cord-005081-kxrzv16n	40	13	chem	chem	NNP
cord-005081-kxrzv16n	40	14	ical	ical	NNP
cord-005081-kxrzv16n	40	15	inactivation	inactivation	NN
cord-005081-kxrzv16n	40	16	or	or	CC
cord-005081-kxrzv16n	40	17	fragmentation	fragmentation	NN
cord-005081-kxrzv16n	40	18	with	with	IN
cord-005081-kxrzv16n	40	19	subsequent	subsequent	JJ
cord-005081-kxrzv16n	40	20	iso	iso	NN
cord-005081-kxrzv16n	40	21	lation	lation	NN
cord-005081-kxrzv16n	40	22	of	of	IN
cord-005081-kxrzv16n	40	23	antigen	antigen	NN
cord-005081-kxrzv16n	40	24	containing	contain	VBG
cord-005081-kxrzv16n	40	25	components	component	NNS
cord-005081-kxrzv16n	40	26	.	.	.
cord-005081-kxrzv16n	41	1	The	the	DT
cord-005081-kxrzv16n	41	2	effi	effi	NNP
cord-005081-kxrzv16n	41	3	cacy	cacy	NN
cord-005081-kxrzv16n	41	4	of	of	IN
cord-005081-kxrzv16n	41	5	inactivated	inactivate	VBN
cord-005081-kxrzv16n	41	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	41	7	in	in	IN
cord-005081-kxrzv16n	41	8	preventing	prevent	VBG
cord-005081-kxrzv16n	41	9	the	the	DT
cord-005081-kxrzv16n	41	10	disease	disease	NN
cord-005081-kxrzv16n	41	11	onset	onset	NN
cord-005081-kxrzv16n	41	12	accounts	account	VBZ
cord-005081-kxrzv16n	41	13	for	for	IN
cord-005081-kxrzv16n	41	14	70	70	CD
cord-005081-kxrzv16n	41	15	-	-	SYM
cord-005081-kxrzv16n	41	16	80	80	CD
cord-005081-kxrzv16n	41	17	%	%	NN
cord-005081-kxrzv16n	41	18	for	for	IN
cord-005081-kxrzv16n	41	19	healthy	healthy	JJ
cord-005081-kxrzv16n	41	20	recipients	recipient	NNS
cord-005081-kxrzv16n	41	21	under	under	IN
cord-005081-kxrzv16n	41	22	65	65	CD
cord-005081-kxrzv16n	41	23	years	year	NNS
cord-005081-kxrzv16n	41	24	of	of	IN
cord-005081-kxrzv16n	41	25	age	age	NN
cord-005081-kxrzv16n	41	26	and	and	CC
cord-005081-kxrzv16n	41	27	30	30	CD
cord-005081-kxrzv16n	41	28	-	-	SYM
cord-005081-kxrzv16n	41	29	40	40	CD
cord-005081-kxrzv16n	41	30	%	%	NN
cord-005081-kxrzv16n	41	31	for	for	IN
cord-005081-kxrzv16n	41	32	patients	patient	NNS
cord-005081-kxrzv16n	41	33	over	over	IN
cord-005081-kxrzv16n	41	34	65	65	CD
cord-005081-kxrzv16n	41	35	.	.	.
cord-005081-kxrzv16n	42	1	On	on	IN
cord-005081-kxrzv16n	42	2	the	the	DT
cord-005081-kxrzv16n	42	3	contrary	contrary	NN
cord-005081-kxrzv16n	42	4	,	,	,
cord-005081-kxrzv16n	42	5	the	the	DT
cord-005081-kxrzv16n	42	6	efficacy	efficacy	NN
cord-005081-kxrzv16n	42	7	of	of	IN
cord-005081-kxrzv16n	42	8	inactivated	inactivate	VBN
cord-005081-kxrzv16n	42	9	vaccines	vaccine	NNS
cord-005081-kxrzv16n	42	10	in	in	IN
cord-005081-kxrzv16n	42	11	preventing	prevent	VBG
cord-005081-kxrzv16n	42	12	influenza	influenza	NN
cord-005081-kxrzv16n	42	13	related	relate	VBN
cord-005081-kxrzv16n	42	14	lethal	lethal	JJ
cord-005081-kxrzv16n	42	15	outcomes	outcome	NNS
cord-005081-kxrzv16n	42	16	accounts	account	VBZ
cord-005081-kxrzv16n	42	17	Table	Table	NNP
cord-005081-kxrzv16n	42	18	2	2	CD
cord-005081-kxrzv16n	42	19	)	)	-RRB-
cord-005081-kxrzv16n	42	20	.	.	.
cord-005081-kxrzv16n	43	1	for	for	IN
cord-005081-kxrzv16n	43	2	80	80	CD
cord-005081-kxrzv16n	43	3	%	%	NN
cord-005081-kxrzv16n	43	4	even	even	RB
cord-005081-kxrzv16n	43	5	among	among	IN
cord-005081-kxrzv16n	43	6	such	such	PDT
cord-005081-kxrzv16n	43	7	a	a	DT
cord-005081-kxrzv16n	43	8	risk	risk	NN
cord-005081-kxrzv16n	43	9	group	group	NN
cord-005081-kxrzv16n	43	10	as	as	IN
cord-005081-kxrzv16n	43	11	patients	patient	NNS
cord-005081-kxrzv16n	43	12	over	over	IN
cord-005081-kxrzv16n	43	13	65	65	CD
cord-005081-kxrzv16n	43	14	years	year	NNS
cord-005081-kxrzv16n	43	15	of	of	IN
cord-005081-kxrzv16n	43	16	age	age	NN
cord-005081-kxrzv16n	43	17	[	[	-LRB-
cord-005081-kxrzv16n	43	18	7	7	CD
cord-005081-kxrzv16n	43	19	,	,	,
cord-005081-kxrzv16n	43	20	12	12	CD
cord-005081-kxrzv16n	43	21	]	]	-RRB-
cord-005081-kxrzv16n	43	22	.	.	.
cord-005081-kxrzv16n	44	1	By	by	IN
cord-005081-kxrzv16n	44	2	their	-PRON-	PRP$
cord-005081-kxrzv16n	44	3	production	production	NN
cord-005081-kxrzv16n	44	4	technologies	technology	NNS
cord-005081-kxrzv16n	44	5	inactivated	inactivate	VBD
cord-005081-kxrzv16n	44	6	vac	vac	NNP
cord-005081-kxrzv16n	44	7	cines	cines	NNP
cord-005081-kxrzv16n	44	8	can	can	MD
cord-005081-kxrzv16n	44	9	be	be	VB
cord-005081-kxrzv16n	44	10	subdivided	subdivide	VBN
cord-005081-kxrzv16n	44	11	into	into	IN
cord-005081-kxrzv16n	44	12	three	three	CD
cord-005081-kxrzv16n	44	13	groups	group	NNS
cord-005081-kxrzv16n	44	14	:	:	:
cord-005081-kxrzv16n	44	15	whole	whole	JJ
cord-005081-kxrzv16n	44	16	vir	vir	NNP
cord-005081-kxrzv16n	44	17	ion	ion	NN
cord-005081-kxrzv16n	44	18	vaccines	vaccine	NNS
cord-005081-kxrzv16n	44	19	(	(	-LRB-
cord-005081-kxrzv16n	44	20	generation	generation	NN
cord-005081-kxrzv16n	44	21	I	I	NNP
cord-005081-kxrzv16n	44	22	)	)	-RRB-
cord-005081-kxrzv16n	44	23	,	,	,
cord-005081-kxrzv16n	44	24	split	split	VBD
cord-005081-kxrzv16n	44	25	vaccines	vaccine	NNS
cord-005081-kxrzv16n	44	26	(	(	-LRB-
cord-005081-kxrzv16n	44	27	generation	generation	NN
cord-005081-kxrzv16n	44	28	II	II	NNP
cord-005081-kxrzv16n	44	29	)	)	-RRB-
cord-005081-kxrzv16n	44	30	and	and	CC
cord-005081-kxrzv16n	44	31	subunit	subunit	NN
cord-005081-kxrzv16n	44	32	vaccines	vaccine	NNS
cord-005081-kxrzv16n	44	33	(	(	-LRB-
cord-005081-kxrzv16n	44	34	generation	generation	NN
cord-005081-kxrzv16n	44	35	III	III	NNP
cord-005081-kxrzv16n	44	36	)	)	-RRB-
cord-005081-kxrzv16n	44	37	(	(	-LRB-
cord-005081-kxrzv16n	44	38	see	see	VB
cord-005081-kxrzv16n	44	39	Fig	Fig	NNP
cord-005081-kxrzv16n	44	40	.	.	NNP
cord-005081-kxrzv16n	44	41	1	1	CD
cord-005081-kxrzv16n	44	42	)	)	-RRB-
cord-005081-kxrzv16n	44	43	.	.	.
cord-005081-kxrzv16n	45	1	Whole	whole	JJ
cord-005081-kxrzv16n	45	2	virion	virion	NN
cord-005081-kxrzv16n	45	3	vaccines	vaccine	NNS
cord-005081-kxrzv16n	45	4	consist	consist	VBP
cord-005081-kxrzv16n	45	5	of	of	IN
cord-005081-kxrzv16n	45	6	inactivated	inactivate	VBN
cord-005081-kxrzv16n	45	7	(	(	-LRB-
cord-005081-kxrzv16n	45	8	chemical	chemical	JJ
cord-005081-kxrzv16n	45	9	or	or	CC
cord-005081-kxrzv16n	45	10	ultraviolet	ultraviolet	NN
cord-005081-kxrzv16n	45	11	inactivation	inactivation	NN
cord-005081-kxrzv16n	45	12	)	)	-RRB-
cord-005081-kxrzv16n	45	13	whole	whole	JJ
cord-005081-kxrzv16n	45	14	virions	virion	NNS
cord-005081-kxrzv16n	45	15	of	of	IN
cord-005081-kxrzv16n	45	16	influenza	influenza	NN
cord-005081-kxrzv16n	45	17	viruses	virus	NNS
cord-005081-kxrzv16n	45	18	and	and	CC
cord-005081-kxrzv16n	45	19	contain	contain	VBP
cord-005081-kxrzv16n	45	20	,	,	,
cord-005081-kxrzv16n	45	21	apart	apart	RB
cord-005081-kxrzv16n	45	22	from	from	IN
cord-005081-kxrzv16n	45	23	the	the	DT
cord-005081-kxrzv16n	45	24	required	require	VBN
cord-005081-kxrzv16n	45	25	antigens	antigen	NNS
cord-005081-kxrzv16n	45	26	for	for	IN
cord-005081-kxrzv16n	45	27	immunization	immunization	NN
cord-005081-kxrzv16n	45	28	,	,	,
cord-005081-kxrzv16n	45	29	a	a	DT
cord-005081-kxrzv16n	45	30	considerable	considerable	JJ
cord-005081-kxrzv16n	45	31	amount	amount	NN
cord-005081-kxrzv16n	45	32	of	of	IN
cord-005081-kxrzv16n	45	33	ballast	ballast	NN
cord-005081-kxrzv16n	45	34	in	in	IN
cord-005081-kxrzv16n	45	35	the	the	DT
cord-005081-kxrzv16n	45	36	form	form	NN
cord-005081-kxrzv16n	45	37	of	of	IN
cord-005081-kxrzv16n	45	38	viral	viral	JJ
cord-005081-kxrzv16n	45	39	nucleocapsid	nucleocapsid	NN
cord-005081-kxrzv16n	45	40	.	.	.
cord-005081-kxrzv16n	46	1	Their	-PRON-	PRP$
cord-005081-kxrzv16n	46	2	advan	advan	JJ
cord-005081-kxrzv16n	46	3	tage	tage	NN
cord-005081-kxrzv16n	46	4	is	be	VBZ
cord-005081-kxrzv16n	46	5	that	that	IN
cord-005081-kxrzv16n	46	6	the	the	DT
cord-005081-kxrzv16n	46	7	surface	surface	NN
cord-005081-kxrzv16n	46	8	antigens	antigen	NNS
cord-005081-kxrzv16n	46	9	in	in	IN
cord-005081-kxrzv16n	46	10	the	the	DT
cord-005081-kxrzv16n	46	11	composition	composition	NN
cord-005081-kxrzv16n	46	12	of	of	IN
cord-005081-kxrzv16n	46	13	inactivated	inactivate	VBN
cord-005081-kxrzv16n	46	14	virions	virion	NNS
cord-005081-kxrzv16n	46	15	are	be	VBP
cord-005081-kxrzv16n	46	16	in	in	IN
cord-005081-kxrzv16n	46	17	conformation	conformation	NN
cord-005081-kxrzv16n	46	18	close	close	RB
cord-005081-kxrzv16n	46	19	to	to	IN
cord-005081-kxrzv16n	46	20	the	the	DT
cord-005081-kxrzv16n	46	21	natural	natural	JJ
cord-005081-kxrzv16n	46	22	one	one	CD
cord-005081-kxrzv16n	46	23	.	.	.
cord-005081-kxrzv16n	47	1	Split	split	JJ
cord-005081-kxrzv16n	47	2	vaccines	vaccine	NNS
cord-005081-kxrzv16n	47	3	are	be	VBP
cord-005081-kxrzv16n	47	4	products	product	NNS
cord-005081-kxrzv16n	47	5	of	of	IN
cord-005081-kxrzv16n	47	6	detergent	detergent	NN
cord-005081-kxrzv16n	47	7	fragmenta	fragmenta	NNP
cord-005081-kxrzv16n	47	8	tion	tion	NNP
cord-005081-kxrzv16n	47	9	of	of	IN
cord-005081-kxrzv16n	47	10	virions	virion	NNS
cord-005081-kxrzv16n	47	11	'	'	POS
cord-005081-kxrzv16n	47	12	membranes	membrane	NNS
cord-005081-kxrzv16n	47	13	with	with	IN
cord-005081-kxrzv16n	47	14	removal	removal	NN
cord-005081-kxrzv16n	47	15	of	of	IN
cord-005081-kxrzv16n	47	16	all	all	DT
cord-005081-kxrzv16n	47	17	compo	compo	NN
cord-005081-kxrzv16n	47	18	nents	nent	NNS
cord-005081-kxrzv16n	47	19	of	of	IN
cord-005081-kxrzv16n	47	20	nucleoid	nucleoid	NNP
cord-005081-kxrzv16n	47	21	and	and	CC
cord-005081-kxrzv16n	47	22	contain	contain	VBP
cord-005081-kxrzv16n	47	23	,	,	,
cord-005081-kxrzv16n	47	24	along	along	IN
cord-005081-kxrzv16n	47	25	with	with	IN
cord-005081-kxrzv16n	47	26	surface	surface	NN
cord-005081-kxrzv16n	47	27	anti	anti	JJ
cord-005081-kxrzv16n	47	28	gens	gen	NNS
cord-005081-kxrzv16n	47	29	,	,	,
cord-005081-kxrzv16n	47	30	internal	internal	JJ
cord-005081-kxrzv16n	47	31	antigens	antigen	NNS
cord-005081-kxrzv16n	47	32	,	,	,
cord-005081-kxrzv16n	47	33	such	such	JJ
cord-005081-kxrzv16n	47	34	as	as	IN
cord-005081-kxrzv16n	47	35	protein	protein	NN
cord-005081-kxrzv16n	47	36	M1	M1	NNP
cord-005081-kxrzv16n	47	37	.	.	.
cord-005081-kxrzv16n	48	1	At	at	IN
cord-005081-kxrzv16n	48	2	the	the	DT
cord-005081-kxrzv16n	48	3	same	same	JJ
cord-005081-kxrzv16n	48	4	time	time	NN
cord-005081-kxrzv16n	48	5	,	,	,
cord-005081-kxrzv16n	48	6	they	-PRON-	PRP
cord-005081-kxrzv16n	48	7	are	be	VBP
cord-005081-kxrzv16n	48	8	real	real	JJ
cord-005081-kxrzv16n	48	9	fragments	fragment	NNS
cord-005081-kxrzv16n	48	10	of	of	IN
cord-005081-kxrzv16n	48	11	highly	highly	RB
cord-005081-kxrzv16n	48	12	purified	purify	VBN
cord-005081-kxrzv16n	48	13	membranes	membrane	NNS
cord-005081-kxrzv16n	48	14	of	of	IN
cord-005081-kxrzv16n	48	15	viral	viral	JJ
cord-005081-kxrzv16n	48	16	particles	particle	NNS
cord-005081-kxrzv16n	48	17	(	(	-LRB-
cord-005081-kxrzv16n	48	18	see	see	VB
cord-005081-kxrzv16n	48	19	Fig	Fig	NNP
cord-005081-kxrzv16n	48	20	.	.	.
cord-005081-kxrzv16n	49	1	1	1	LS
cord-005081-kxrzv16n	49	2	,	,	,
cord-005081-kxrzv16n	49	3	phase	phase	NN
cord-005081-kxrzv16n	49	4	2	2	CD
cord-005081-kxrzv16n	49	5	)	)	-RRB-
cord-005081-kxrzv16n	49	6	.	.	.
cord-005081-kxrzv16n	50	1	Subunit	subunit	NN
cord-005081-kxrzv16n	50	2	vaccines	vaccine	NNS
cord-005081-kxrzv16n	50	3	contain	contain	VBP
cord-005081-kxrzv16n	50	4	only	only	RB
cord-005081-kxrzv16n	50	5	surface	surface	NN
cord-005081-kxrzv16n	50	6	protective	protective	JJ
cord-005081-kxrzv16n	50	7	antigens	antigen	NNS
cord-005081-kxrzv16n	50	8	(	(	-LRB-
cord-005081-kxrzv16n	50	9	haemagglutinin	haemagglutinin	NNP
cord-005081-kxrzv16n	50	10	and	and	CC
cord-005081-kxrzv16n	50	11	neuraminidase	neuraminidase	NN
cord-005081-kxrzv16n	50	12	,	,	,
cord-005081-kxrzv16n	50	13	pre	pre	VBD
cord-005081-kxrzv16n	50	14	dominantly	dominantly	RB
cord-005081-kxrzv16n	50	15	,	,	,
cord-005081-kxrzv16n	50	16	the	the	DT
cord-005081-kxrzv16n	50	17	former	former	JJ
cord-005081-kxrzv16n	50	18	)	)	-RRB-
cord-005081-kxrzv16n	50	19	and	and	CC
cord-005081-kxrzv16n	50	20	are	be	VBP
cord-005081-kxrzv16n	50	21	preparations	preparation	NNS
cord-005081-kxrzv16n	50	22	with	with	IN
cord-005081-kxrzv16n	50	23	the	the	DT
cord-005081-kxrzv16n	50	24	highest	high	JJS
cord-005081-kxrzv16n	50	25	degree	degree	NN
cord-005081-kxrzv16n	50	26	of	of	IN
cord-005081-kxrzv16n	50	27	purification	purification	NN
cord-005081-kxrzv16n	50	28	from	from	IN
cord-005081-kxrzv16n	50	29	influenza	influenza	NN
cord-005081-kxrzv16n	50	30	virus	virus	NN
cord-005081-kxrzv16n	50	31	components	component	NNS
cord-005081-kxrzv16n	50	32	.	.	.
cord-005081-kxrzv16n	51	1	To	to	IN
cord-005081-kxrzv16n	51	2	the	the	DT
cord-005081-kxrzv16n	51	3	group	group	NN
cord-005081-kxrzv16n	51	4	of	of	IN
cord-005081-kxrzv16n	51	5	subunit	subunit	NN
cord-005081-kxrzv16n	51	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	51	7	,	,	,
cord-005081-kxrzv16n	51	8	for	for	IN
cord-005081-kxrzv16n	51	9	example	example	NN
cord-005081-kxrzv16n	51	10	,	,	,
cord-005081-kxrzv16n	51	11	belongs	belong	VBZ
cord-005081-kxrzv16n	51	12	Grippol	Grippol	NNP
cord-005081-kxrzv16n	51	13	,	,	,
cord-005081-kxrzv16n	51	14	a	a	DT
cord-005081-kxrzv16n	51	15	polymer	polymer	NN
cord-005081-kxrzv16n	51	16	,	,	,
cord-005081-kxrzv16n	51	17	which	which	WDT
cord-005081-kxrzv16n	51	18	can	can	MD
cord-005081-kxrzv16n	51	19	not	not	RB
cord-005081-kxrzv16n	51	20	be	be	VB
cord-005081-kxrzv16n	51	21	characterized	characterize	VBN
cord-005081-kxrzv16n	51	22	as	as	IN
cord-005081-kxrzv16n	51	23	an	an	DT
cord-005081-kxrzv16n	51	24	ideal	ideal	JJ
cord-005081-kxrzv16n	51	25	preparation	preparation	NN
cord-005081-kxrzv16n	51	26	(	(	-LRB-
cord-005081-kxrzv16n	51	27	see	see	VB
cord-005081-kxrzv16n	51	28	below	below	RB
cord-005081-kxrzv16n	51	29	)	)	-RRB-
cord-005081-kxrzv16n	51	30	.	.	.
cord-005081-kxrzv16n	52	1	The	the	DT
cord-005081-kxrzv16n	52	2	main	main	JJ
cord-005081-kxrzv16n	52	3	requirements	requirement	NNS
cord-005081-kxrzv16n	52	4	for	for	IN
cord-005081-kxrzv16n	52	5	the	the	DT
cord-005081-kxrzv16n	52	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	52	7	and	and	CC
cord-005081-kxrzv16n	52	8	their	-PRON-	PRP$
cord-005081-kxrzv16n	52	9	pro	pro	JJ
cord-005081-kxrzv16n	52	10	duction	duction	NN
cord-005081-kxrzv16n	52	11	technologies	technology	NNS
cord-005081-kxrzv16n	52	12	were	be	VBD
cord-005081-kxrzv16n	52	13	first	first	RB
cord-005081-kxrzv16n	52	14	specified	specify	VBN
cord-005081-kxrzv16n	52	15	under	under	IN
cord-005081-kxrzv16n	52	16	the	the	DT
cord-005081-kxrzv16n	52	17	WHO	WHO	NNP
cord-005081-kxrzv16n	52	18	's	's	POS
cord-005081-kxrzv16n	52	19	special	special	JJ
cord-005081-kxrzv16n	52	20	document	document	NN
cord-005081-kxrzv16n	52	21	[	[	-LRB-
cord-005081-kxrzv16n	52	22	8	8	CD
cord-005081-kxrzv16n	52	23	,	,	,
cord-005081-kxrzv16n	52	24	13	13	CD
cord-005081-kxrzv16n	52	25	]	]	-RRB-
cord-005081-kxrzv16n	52	26	.	.	.
cord-005081-kxrzv16n	53	1	Live	live	VB
cord-005081-kxrzv16n	53	2	attenuated	attenuated	JJ
cord-005081-kxrzv16n	53	3	influenza	influenza	NN
cord-005081-kxrzv16n	53	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	53	5	,	,	,
cord-005081-kxrzv16n	53	6	proposed	propose	VBN
cord-005081-kxrzv16n	53	7	at	at	IN
cord-005081-kxrzv16n	53	8	first	first	RB
cord-005081-kxrzv16n	53	9	by	by	IN
cord-005081-kxrzv16n	53	10	A.A.	A.A.	NNP
cord-005081-kxrzv16n	53	11	Smorodintsev	Smorodintsev	NNP
cord-005081-kxrzv16n	53	12	in	in	IN
cord-005081-kxrzv16n	53	13	1938	1938	CD
cord-005081-kxrzv16n	53	14	,	,	,
cord-005081-kxrzv16n	53	15	have	have	VBP
cord-005081-kxrzv16n	53	16	successfully	successfully	RB
cord-005081-kxrzv16n	53	17	been	be	VBN
cord-005081-kxrzv16n	53	18	applied	apply	VBN
cord-005081-kxrzv16n	53	19	in	in	IN
cord-005081-kxrzv16n	53	20	Russia	Russia	NNP
cord-005081-kxrzv16n	53	21	for	for	IN
cord-005081-kxrzv16n	53	22	decades	decade	NNS
cord-005081-kxrzv16n	53	23	.	.	.
cord-005081-kxrzv16n	54	1	In	in	IN
cord-005081-kxrzv16n	54	2	the	the	DT
cord-005081-kxrzv16n	54	3	United	United	NNP
cord-005081-kxrzv16n	54	4	States	States	NNP
cord-005081-kxrzv16n	54	5	,	,	,
cord-005081-kxrzv16n	54	6	a	a	DT
cord-005081-kxrzv16n	54	7	live	live	JJ
cord-005081-kxrzv16n	54	8	intranasal	intranasal	NN
cord-005081-kxrzv16n	54	9	vaccine	vaccine	NN
cord-005081-kxrzv16n	54	10	was	be	VBD
cord-005081-kxrzv16n	54	11	approved	approve	VBN
cord-005081-kxrzv16n	54	12	by	by	IN
cord-005081-kxrzv16n	54	13	the	the	DT
cord-005081-kxrzv16n	54	14	FDA	FDA	NNP
cord-005081-kxrzv16n	54	15	in	in	IN
cord-005081-kxrzv16n	54	16	June	June	NNP
cord-005081-kxrzv16n	54	17	2003	2003	CD
cord-005081-kxrzv16n	54	18	and	and	CC
cord-005081-kxrzv16n	54	19	permitted	permit	VBD
cord-005081-kxrzv16n	54	20	its	-PRON-	PRP$
cord-005081-kxrzv16n	54	21	use	use	NN
cord-005081-kxrzv16n	54	22	in	in	IN
cord-005081-kxrzv16n	54	23	age	age	NN
cord-005081-kxrzv16n	54	24	groups	group	NNS
cord-005081-kxrzv16n	54	25	ranging	range	VBG
cord-005081-kxrzv16n	54	26	from	from	IN
cord-005081-kxrzv16n	54	27	5	5	CD
cord-005081-kxrzv16n	54	28	to	to	TO
cord-005081-kxrzv16n	54	29	49	49	CD
cord-005081-kxrzv16n	54	30	years	year	NNS
cord-005081-kxrzv16n	54	31	.	.	.
cord-005081-kxrzv16n	55	1	Repetitive	repetitive	JJ
cord-005081-kxrzv16n	55	2	passages	passage	NNS
cord-005081-kxrzv16n	55	3	on	on	IN
cord-005081-kxrzv16n	55	4	chicken	chicken	NN
cord-005081-kxrzv16n	55	5	embryos	embryo	NNS
cord-005081-kxrzv16n	55	6	in	in	IN
cord-005081-kxrzv16n	55	7	decreased	decrease	VBN
cord-005081-kxrzv16n	55	8	temperature	temperature	NN
cord-005081-kxrzv16n	55	9	conditions	condition	NNS
cord-005081-kxrzv16n	55	10	allowed	allow	VBD
cord-005081-kxrzv16n	55	11	researchers	researcher	NNS
cord-005081-kxrzv16n	55	12	to	to	TO
cord-005081-kxrzv16n	55	13	obtain	obtain	VB
cord-005081-kxrzv16n	55	14	a	a	DT
cord-005081-kxrzv16n	55	15	weakened	weakened	JJ
cord-005081-kxrzv16n	55	16	virus	virus	NN
cord-005081-kxrzv16n	55	17	that	that	WDT
cord-005081-kxrzv16n	55	18	does	do	VBZ
cord-005081-kxrzv16n	55	19	not	not	RB
cord-005081-kxrzv16n	55	20	replicate	replicate	VB
cord-005081-kxrzv16n	55	21	at	at	IN
cord-005081-kxrzv16n	55	22	high	high	JJ
cord-005081-kxrzv16n	55	23	temperatures	temperature	NNS
cord-005081-kxrzv16n	55	24	,	,	,
cord-005081-kxrzv16n	55	25	characteristic	characteristic	JJ
cord-005081-kxrzv16n	55	26	of	of	IN
cord-005081-kxrzv16n	55	27	human	human	JJ
cord-005081-kxrzv16n	55	28	lungs	lung	NNS
cord-005081-kxrzv16n	55	29	,	,	,
cord-005081-kxrzv16n	55	30	but	but	CC
cord-005081-kxrzv16n	55	31	can	can	MD
cord-005081-kxrzv16n	55	32	propagate	propagate	VB
cord-005081-kxrzv16n	55	33	in	in	IN
cord-005081-kxrzv16n	55	34	the	the	DT
cord-005081-kxrzv16n	55	35	nasopharynx	nasopharynx	NN
cord-005081-kxrzv16n	55	36	at	at	IN
cord-005081-kxrzv16n	55	37	a	a	DT
cord-005081-kxrzv16n	55	38	temperature	temperature	NN
cord-005081-kxrzv16n	55	39	of	of	IN
cord-005081-kxrzv16n	55	40	34	34	CD
cord-005081-kxrzv16n	55	41	°	°	NN
cord-005081-kxrzv16n	55	42	C	c	NN
cord-005081-kxrzv16n	55	43	,	,	,
cord-005081-kxrzv16n	55	44	causing	cause	VBG
cord-005081-kxrzv16n	55	45	a	a	DT
cord-005081-kxrzv16n	55	46	topical	topical	JJ
cord-005081-kxrzv16n	55	47	infection	infection	NN
cord-005081-kxrzv16n	55	48	leading	lead	VBG
cord-005081-kxrzv16n	55	49	to	to	IN
cord-005081-kxrzv16n	55	50	the	the	DT
cord-005081-kxrzv16n	55	51	development	development	NN
cord-005081-kxrzv16n	55	52	of	of	IN
cord-005081-kxrzv16n	55	53	a	a	DT
cord-005081-kxrzv16n	55	54	secretory	secretory	JJ
cord-005081-kxrzv16n	55	55	and	and	CC
cord-005081-kxrzv16n	55	56	general	general	JJ
cord-005081-kxrzv16n	55	57	ized	ized	NNP
cord-005081-kxrzv16n	55	58	immune	immune	JJ
cord-005081-kxrzv16n	55	59	response	response	NN
cord-005081-kxrzv16n	55	60	[	[	-LRB-
cord-005081-kxrzv16n	55	61	1	1	CD
cord-005081-kxrzv16n	55	62	,	,	,
cord-005081-kxrzv16n	55	63	14	14	CD
cord-005081-kxrzv16n	55	64	]	]	-RRB-
cord-005081-kxrzv16n	55	65	.	.	.
cord-005081-kxrzv16n	56	1	Since	since	IN
cord-005081-kxrzv16n	56	2	the	the	DT
cord-005081-kxrzv16n	56	3	LAIV	LAIV	NNP
cord-005081-kxrzv16n	56	4	vacci	vacci	NNP
cord-005081-kxrzv16n	56	5	nation	nation	NN
cord-005081-kxrzv16n	56	6	resembles	resemble	VBZ
cord-005081-kxrzv16n	56	7	a	a	DT
cord-005081-kxrzv16n	56	8	naturally	naturally	RB
cord-005081-kxrzv16n	56	9	occurring	occur	VBG
cord-005081-kxrzv16n	56	10	transient	transient	JJ
cord-005081-kxrzv16n	56	11	infection	infection	NN
cord-005081-kxrzv16n	56	12	,	,	,
cord-005081-kxrzv16n	56	13	it	-PRON-	PRP
cord-005081-kxrzv16n	56	14	has	have	VBZ
cord-005081-kxrzv16n	56	15	a	a	DT
cord-005081-kxrzv16n	56	16	sufficient	sufficient	JJ
cord-005081-kxrzv16n	56	17	efficacy	efficacy	NN
cord-005081-kxrzv16n	56	18	and	and	CC
cord-005081-kxrzv16n	56	19	is	be	VBZ
cord-005081-kxrzv16n	56	20	character	character	NN
cord-005081-kxrzv16n	56	21	ized	ized	NN
cord-005081-kxrzv16n	56	22	,	,	,
cord-005081-kxrzv16n	56	23	according	accord	VBG
cord-005081-kxrzv16n	56	24	to	to	IN
cord-005081-kxrzv16n	56	25	different	different	JJ
cord-005081-kxrzv16n	56	26	sources	source	NNS
cord-005081-kxrzv16n	56	27	,	,	,
cord-005081-kxrzv16n	56	28	by	by	IN
cord-005081-kxrzv16n	56	29	94	94	CD
cord-005081-kxrzv16n	56	30	%	%	NN
cord-005081-kxrzv16n	56	31	serocon	serocon	NN
cord-005081-kxrzv16n	56	32	version	version	NN
cord-005081-kxrzv16n	56	33	in	in	IN
cord-005081-kxrzv16n	56	34	children	child	NNS
cord-005081-kxrzv16n	56	35	,	,	,
cord-005081-kxrzv16n	56	36	while	while	IN
cord-005081-kxrzv16n	56	37	,	,	,
cord-005081-kxrzv16n	56	38	in	in	IN
cord-005081-kxrzv16n	56	39	combination	combination	NN
cord-005081-kxrzv16n	56	40	with	with	IN
cord-005081-kxrzv16n	56	41	an	an	DT
cord-005081-kxrzv16n	56	42	inactivated	inactivated	JJ
cord-005081-kxrzv16n	56	43	vaccine	vaccine	NN
cord-005081-kxrzv16n	56	44	,	,	,
cord-005081-kxrzv16n	56	45	it	-PRON-	PRP
cord-005081-kxrzv16n	56	46	elicits	elicit	VBZ
cord-005081-kxrzv16n	56	47	a	a	DT
cord-005081-kxrzv16n	56	48	positive	positive	JJ
cord-005081-kxrzv16n	56	49	immune	immune	JJ
cord-005081-kxrzv16n	56	50	response	response	NN
cord-005081-kxrzv16n	56	51	in	in	IN
cord-005081-kxrzv16n	56	52	68	68	CD
cord-005081-kxrzv16n	56	53	%	%	NN
cord-005081-kxrzv16n	56	54	of	of	IN
cord-005081-kxrzv16n	56	55	the	the	DT
cord-005081-kxrzv16n	56	56	elderly	elderly	JJ
cord-005081-kxrzv16n	56	57	[	[	-LRB-
cord-005081-kxrzv16n	56	58	1	1	CD
cord-005081-kxrzv16n	56	59	,	,	,
cord-005081-kxrzv16n	56	60	6	6	CD
cord-005081-kxrzv16n	56	61	]	]	-RRB-
cord-005081-kxrzv16n	56	62	.	.	.
cord-005081-kxrzv16n	57	1	The	the	DT
cord-005081-kxrzv16n	57	2	overwhelming	overwhelming	JJ
cord-005081-kxrzv16n	57	3	majority	majority	NN
cord-005081-kxrzv16n	57	4	of	of	IN
cord-005081-kxrzv16n	57	5	seasonal	seasonal	NNP
cord-005081-kxrzv16n	57	6	and	and	CC
cord-005081-kxrzv16n	57	7	pan	pan	NNP
cord-005081-kxrzv16n	57	8	demic	demic	JJ
cord-005081-kxrzv16n	57	9	viruses	virus	NNS
cord-005081-kxrzv16n	57	10	are	be	VBP
cord-005081-kxrzv16n	57	11	products	product	NNS
cord-005081-kxrzv16n	57	12	of	of	IN
cord-005081-kxrzv16n	57	13	reassortment	reassortment	NN
cord-005081-kxrzv16n	57	14	1	1	CD
cord-005081-kxrzv16n	57	15	[	[	-LRB-
cord-005081-kxrzv16n	57	16	1	1	CD
cord-005081-kxrzv16n	57	17	,	,	,
cord-005081-kxrzv16n	57	18	14	14	CD
cord-005081-kxrzv16n	57	19	]	]	-RRB-
cord-005081-kxrzv16n	57	20	.	.	.
cord-005081-kxrzv16n	58	1	First	first	RB
cord-005081-kxrzv16n	58	2	of	of	IN
cord-005081-kxrzv16n	58	3	all	all	DT
cord-005081-kxrzv16n	58	4	,	,	,
cord-005081-kxrzv16n	58	5	this	this	DT
cord-005081-kxrzv16n	58	6	applies	apply	VBZ
cord-005081-kxrzv16n	58	7	to	to	IN
cord-005081-kxrzv16n	58	8	the	the	DT
cord-005081-kxrzv16n	58	9	current	current	JJ
cord-005081-kxrzv16n	58	10	H1N1v	H1N1v	NNP
cord-005081-kxrzv16n	58	11	2009	2009	CD
cord-005081-kxrzv16n	58	12	virus	virus	NN
cord-005081-kxrzv16n	58	13	,	,	,
cord-005081-kxrzv16n	58	14	the	the	DT
cord-005081-kxrzv16n	58	15	agent	agent	NN
cord-005081-kxrzv16n	58	16	of	of	IN
cord-005081-kxrzv16n	58	17	the	the	DT
cord-005081-kxrzv16n	58	18	influenza	influenza	NN
cord-005081-kxrzv16n	58	19	pandemic	pandemic	NN
cord-005081-kxrzv16n	58	20	.	.	.
cord-005081-kxrzv16n	59	1	Therefore	therefore	RB
cord-005081-kxrzv16n	59	2	,	,	,
cord-005081-kxrzv16n	59	3	application	application	NN
cord-005081-kxrzv16n	59	4	of	of	IN
cord-005081-kxrzv16n	59	5	LAIV	LAIV	NNP
cord-005081-kxrzv16n	59	6	for	for	IN
cord-005081-kxrzv16n	59	7	preventing	prevent	VBG
cord-005081-kxrzv16n	59	8	the	the	DT
cord-005081-kxrzv16n	59	9	emergence	emergence	NN
cord-005081-kxrzv16n	59	10	of	of	IN
cord-005081-kxrzv16n	59	11	reassortants	reassortant	NNS
cord-005081-kxrzv16n	59	12	with	with	IN
cord-005081-kxrzv16n	59	13	novel	novel	JJ
cord-005081-kxrzv16n	59	14	properties	property	NNS
cord-005081-kxrzv16n	59	15	is	be	VBZ
cord-005081-kxrzv16n	59	16	restricted	restrict	VBN
cord-005081-kxrzv16n	59	17	on	on	IN
cord-005081-kxrzv16n	59	18	a	a	DT
cord-005081-kxrzv16n	59	19	rise	rise	NN
cord-005081-kxrzv16n	59	20	1	1	CD
cord-005081-kxrzv16n	60	1	Reassortment	Reassortment	NNP
cord-005081-kxrzv16n	60	2	is	be	VBZ
cord-005081-kxrzv16n	60	3	an	an	DT
cord-005081-kxrzv16n	60	4	exchange	exchange	NN
cord-005081-kxrzv16n	60	5	of	of	IN
cord-005081-kxrzv16n	60	6	viral	viral	JJ
cord-005081-kxrzv16n	60	7	genome	genome	NN
cord-005081-kxrzv16n	60	8	fragments	fragment	NNS
cord-005081-kxrzv16n	60	9	between	between	IN
cord-005081-kxrzv16n	60	10	two	two	CD
cord-005081-kxrzv16n	60	11	or	or	CC
cord-005081-kxrzv16n	60	12	more	more	JJR
cord-005081-kxrzv16n	60	13	viruses	virus	NNS
cord-005081-kxrzv16n	60	14	.	.	.
cord-005081-kxrzv16n	61	1	of	of	IN
cord-005081-kxrzv16n	61	2	morbidity	morbidity	NN
cord-005081-kxrzv16n	61	3	and	and	CC
cord-005081-kxrzv16n	61	4	the	the	DT
cord-005081-kxrzv16n	61	5	more	more	RBR
cord-005081-kxrzv16n	61	6	so	so	RB
cord-005081-kxrzv16n	61	7	in	in	IN
cord-005081-kxrzv16n	61	8	the	the	DT
cord-005081-kxrzv16n	61	9	outbreak	outbreak	NN
cord-005081-kxrzv16n	61	10	of	of	IN
cord-005081-kxrzv16n	61	11	an	an	DT
cord-005081-kxrzv16n	61	12	influenza	influenza	NN
cord-005081-kxrzv16n	61	13	pandemic	pandemic	NN
cord-005081-kxrzv16n	61	14	.	.	.
cord-005081-kxrzv16n	62	1	The	the	DT
cord-005081-kxrzv16n	62	2	data	datum	NNS
cord-005081-kxrzv16n	62	3	on	on	IN
cord-005081-kxrzv16n	62	4	the	the	DT
cord-005081-kxrzv16n	62	5	age	age	NN
cord-005081-kxrzv16n	62	6	related	relate	VBN
cord-005081-kxrzv16n	62	7	lethality	lethality	NN
cord-005081-kxrzv16n	62	8	from	from	IN
cord-005081-kxrzv16n	62	9	the	the	DT
cord-005081-kxrzv16n	62	10	pan	pan	NNP
cord-005081-kxrzv16n	62	11	demic	demic	NNP
cord-005081-kxrzv16n	62	12	H1N1v	H1N1v	NNP
cord-005081-kxrzv16n	63	1	2009	2009	CD
cord-005081-kxrzv16n	63	2	influenza	influenza	NN
cord-005081-kxrzv16n	63	3	has	have	VBZ
cord-005081-kxrzv16n	63	4	shown	show	VBN
cord-005081-kxrzv16n	63	5	that	that	IN
cord-005081-kxrzv16n	63	6	the	the	DT
cord-005081-kxrzv16n	63	7	morbidity	morbidity	NN
cord-005081-kxrzv16n	63	8	and	and	CC
cord-005081-kxrzv16n	63	9	mortality	mortality	NN
cord-005081-kxrzv16n	63	10	from	from	IN
cord-005081-kxrzv16n	63	11	influenza	influenza	NN
cord-005081-kxrzv16n	63	12	related	relate	VBN
cord-005081-kxrzv16n	63	13	com	com	NN
cord-005081-kxrzv16n	63	14	plications	plication	NNS
cord-005081-kxrzv16n	63	15	in	in	IN
cord-005081-kxrzv16n	63	16	the	the	DT
cord-005081-kxrzv16n	63	17	period	period	NN
cord-005081-kxrzv16n	63	18	from	from	IN
cord-005081-kxrzv16n	63	19	March	March	NNP
cord-005081-kxrzv16n	63	20	to	to	IN
cord-005081-kxrzv16n	63	21	December	December	NNP
cord-005081-kxrzv16n	63	22	2009	2009	CD
cord-005081-kxrzv16n	63	23	were	be	VBD
cord-005081-kxrzv16n	63	24	significantly	significantly	RB
cord-005081-kxrzv16n	63	25	lower	low	JJR
cord-005081-kxrzv16n	63	26	among	among	IN
cord-005081-kxrzv16n	63	27	patients	patient	NNS
cord-005081-kxrzv16n	63	28	born	bear	VBN
cord-005081-kxrzv16n	63	29	after	after	IN
cord-005081-kxrzv16n	63	30	1957	1957	CD
cord-005081-kxrzv16n	63	31	.	.	.
cord-005081-kxrzv16n	64	1	A	a	DT
cord-005081-kxrzv16n	64	2	relatively	relatively	RB
cord-005081-kxrzv16n	64	3	high	high	JJ
cord-005081-kxrzv16n	64	4	level	level	NN
cord-005081-kxrzv16n	64	5	of	of	IN
cord-005081-kxrzv16n	64	6	antibodies	antibody	NNS
cord-005081-kxrzv16n	64	7	to	to	IN
cord-005081-kxrzv16n	64	8	the	the	DT
cord-005081-kxrzv16n	64	9	swine	swine	NN
cord-005081-kxrzv16n	64	10	lineage	lineage	NN
cord-005081-kxrzv16n	64	11	H1N1viruses	H1N1viruses	NNP
cord-005081-kxrzv16n	64	12	was	be	VBD
cord-005081-kxrzv16n	64	13	revealed	reveal	VBN
cord-005081-kxrzv16n	64	14	in	in	IN
cord-005081-kxrzv16n	64	15	patients	patient	NNS
cord-005081-kxrzv16n	64	16	over	over	IN
cord-005081-kxrzv16n	64	17	50	50	CD
cord-005081-kxrzv16n	64	18	to	to	TO
cord-005081-kxrzv16n	64	19	55	55	CD
cord-005081-kxrzv16n	64	20	years	year	NNS
cord-005081-kxrzv16n	64	21	of	of	IN
cord-005081-kxrzv16n	64	22	age	age	NN
cord-005081-kxrzv16n	64	23	,	,	,
cord-005081-kxrzv16n	64	24	which	which	WDT
cord-005081-kxrzv16n	64	25	defines	define	VBZ
cord-005081-kxrzv16n	64	26	a	a	DT
cord-005081-kxrzv16n	64	27	sufficiently	sufficiently	RB
cord-005081-kxrzv16n	64	28	high	high	JJ
cord-005081-kxrzv16n	64	29	level	level	NN
cord-005081-kxrzv16n	64	30	of	of	IN
cord-005081-kxrzv16n	64	31	protection	protection	NN
cord-005081-kxrzv16n	64	32	against	against	IN
cord-005081-kxrzv16n	64	33	the	the	DT
cord-005081-kxrzv16n	64	34	current	current	JJ
cord-005081-kxrzv16n	64	35	pandemic	pandemic	NN
cord-005081-kxrzv16n	64	36	H1N1v	h1n1v	CD
cord-005081-kxrzv16n	65	1	2009	2009	CD
cord-005081-kxrzv16n	65	2	influenza	influenza	NN
cord-005081-kxrzv16n	65	3	[	[	-LRB-
cord-005081-kxrzv16n	65	4	12	12	CD
cord-005081-kxrzv16n	65	5	,	,	,
cord-005081-kxrzv16n	65	6	15	15	CD
cord-005081-kxrzv16n	65	7	,	,	,
cord-005081-kxrzv16n	65	8	16	16	CD
cord-005081-kxrzv16n	65	9	]	]	-RRB-
cord-005081-kxrzv16n	65	10	.	.	.
cord-005081-kxrzv16n	66	1	These	these	DT
cord-005081-kxrzv16n	66	2	data	datum	NNS
cord-005081-kxrzv16n	66	3	evi	evi	NNP
cord-005081-kxrzv16n	66	4	dence	dence	NN
cord-005081-kxrzv16n	66	5	in	in	IN
cord-005081-kxrzv16n	66	6	favor	favor	NN
cord-005081-kxrzv16n	66	7	of	of	IN
cord-005081-kxrzv16n	66	8	conducting	conduct	VBG
cord-005081-kxrzv16n	66	9	a	a	DT
cord-005081-kxrzv16n	66	10	total	total	JJ
cord-005081-kxrzv16n	66	11	vaccination	vaccination	NN
cord-005081-kxrzv16n	66	12	in	in	IN
cord-005081-kxrzv16n	66	13	rel	rel	NNP
cord-005081-kxrzv16n	66	14	atively	atively	RB
cord-005081-kxrzv16n	66	15	young	young	JJ
cord-005081-kxrzv16n	66	16	groups	group	NNS
cord-005081-kxrzv16n	66	17	of	of	IN
cord-005081-kxrzv16n	66	18	the	the	DT
cord-005081-kxrzv16n	66	19	population	population	NN
cord-005081-kxrzv16n	66	20	and	and	CC
cord-005081-kxrzv16n	66	21	children	child	NNS
cord-005081-kxrzv16n	66	22	in	in	IN
cord-005081-kxrzv16n	66	23	the	the	DT
cord-005081-kxrzv16n	66	24	coming	come	VBG
cord-005081-kxrzv16n	66	25	period	period	NN
cord-005081-kxrzv16n	66	26	prior	prior	RB
cord-005081-kxrzv16n	66	27	to	to	IN
cord-005081-kxrzv16n	66	28	the	the	DT
cord-005081-kxrzv16n	66	29	second	second	JJ
cord-005081-kxrzv16n	66	30	wave	wave	NN
cord-005081-kxrzv16n	66	31	of	of	IN
cord-005081-kxrzv16n	66	32	the	the	DT
cord-005081-kxrzv16n	66	33	pan	pan	NNP
cord-005081-kxrzv16n	66	34	demic	demic	NNP
cord-005081-kxrzv16n	66	35	expected	expect	VBN
cord-005081-kxrzv16n	66	36	in	in	IN
cord-005081-kxrzv16n	66	37	2010	2010	CD
cord-005081-kxrzv16n	66	38	-	-	SYM
cord-005081-kxrzv16n	66	39	2011	2011	CD
cord-005081-kxrzv16n	66	40	.	.	.
cord-005081-kxrzv16n	67	1	Table	table	NN
cord-005081-kxrzv16n	67	2	1	1	CD
cord-005081-kxrzv16n	67	3	gives	give	VBZ
cord-005081-kxrzv16n	67	4	a	a	DT
cord-005081-kxrzv16n	67	5	group	group	NN
cord-005081-kxrzv16n	67	6	of	of	IN
cord-005081-kxrzv16n	67	7	12	12	CD
cord-005081-kxrzv16n	67	8	influenza	influenza	NN
cord-005081-kxrzv16n	67	9	vaccine	vaccine	NN
cord-005081-kxrzv16n	67	10	prep	prep	NN
cord-005081-kxrzv16n	67	11	arations	aration	NNS
cord-005081-kxrzv16n	67	12	by	by	IN
cord-005081-kxrzv16n	67	13	domestic	domestic	JJ
cord-005081-kxrzv16n	67	14	and	and	CC
cord-005081-kxrzv16n	67	15	foreign	foreign	JJ
cord-005081-kxrzv16n	67	16	producers	producer	NNS
cord-005081-kxrzv16n	67	17	,	,	,
cord-005081-kxrzv16n	67	18	which	which	WDT
cord-005081-kxrzv16n	67	19	are	be	VBP
cord-005081-kxrzv16n	67	20	now	now	RB
cord-005081-kxrzv16n	67	21	manufactured	manufacture	VBN
cord-005081-kxrzv16n	67	22	or	or	CC
cord-005081-kxrzv16n	67	23	registered	register	VBN
cord-005081-kxrzv16n	67	24	in	in	IN
cord-005081-kxrzv16n	67	25	Russia	Russia	NNP
cord-005081-kxrzv16n	67	26	.	.	.
cord-005081-kxrzv16n	68	1	CONSTRUCTION	CONSTRUCTION	NNP
cord-005081-kxrzv16n	68	2	Studies	study	NNS
cord-005081-kxrzv16n	68	3	on	on	IN
cord-005081-kxrzv16n	68	4	developing	develop	VBG
cord-005081-kxrzv16n	68	5	influenza	influenza	NN
cord-005081-kxrzv16n	68	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	68	7	and	and	CC
cord-005081-kxrzv16n	68	8	their	-PRON-	PRP$
cord-005081-kxrzv16n	68	9	production	production	NN
cord-005081-kxrzv16n	68	10	technologies	technology	NNS
cord-005081-kxrzv16n	68	11	have	have	VBP
cord-005081-kxrzv16n	68	12	been	be	VBN
cord-005081-kxrzv16n	68	13	extended	extend	VBN
cord-005081-kxrzv16n	68	14	in	in	IN
cord-005081-kxrzv16n	68	15	the	the	DT
cord-005081-kxrzv16n	68	16	most	most	RBS
cord-005081-kxrzv16n	68	17	recent	recent	JJ
cord-005081-kxrzv16n	68	18	5	5	CD
cord-005081-kxrzv16n	68	19	years	year	NNS
cord-005081-kxrzv16n	68	20	thanks	thank	NNS
cord-005081-kxrzv16n	68	21	to	to	IN
cord-005081-kxrzv16n	68	22	the	the	DT
cord-005081-kxrzv16n	68	23	deployed	deploy	VBN
cord-005081-kxrzv16n	68	24	program	program	NN
cord-005081-kxrzv16n	68	25	on	on	IN
cord-005081-kxrzv16n	68	26	influenza	influenza	JJ
cord-005081-kxrzv16n	68	27	pandemic	pandemic	NNP
cord-005081-kxrzv16n	68	28	preparedness	preparedness	NN
cord-005081-kxrzv16n	68	29	.	.	.
cord-005081-kxrzv16n	69	1	The	the	DT
cord-005081-kxrzv16n	69	2	WHO	who	WP
cord-005081-kxrzv16n	69	3	has	have	VBZ
cord-005081-kxrzv16n	69	4	adopted	adopt	VBN
cord-005081-kxrzv16n	69	5	a	a	DT
cord-005081-kxrzv16n	69	6	special	special	JJ
cord-005081-kxrzv16n	69	7	technology	technology	NN
cord-005081-kxrzv16n	69	8	transfer	transfer	NN
cord-005081-kxrzv16n	69	9	program	program	NN
cord-005081-kxrzv16n	69	10	on	on	IN
cord-005081-kxrzv16n	69	11	developing	develop	VBG
cord-005081-kxrzv16n	69	12	influenza	influenza	JJ
cord-005081-kxrzv16n	69	13	vaccine	vaccine	NN
cord-005081-kxrzv16n	69	14	production	production	NN
cord-005081-kxrzv16n	69	15	in	in	IN
cord-005081-kxrzv16n	69	16	third	third	JJ
cord-005081-kxrzv16n	69	17	world	world	NN
cord-005081-kxrzv16n	69	18	countries	country	NNS
cord-005081-kxrzv16n	69	19	.	.	.
cord-005081-kxrzv16n	70	1	Europe	Europe	NNP
cord-005081-kxrzv16n	70	2	and	and	CC
cord-005081-kxrzv16n	70	3	the	the	DT
cord-005081-kxrzv16n	70	4	United	United	NNP
cord-005081-kxrzv16n	70	5	States	States	NNP
cord-005081-kxrzv16n	70	6	agreed	agree	VBD
cord-005081-kxrzv16n	70	7	to	to	TO
cord-005081-kxrzv16n	70	8	allot	allot	VB
cord-005081-kxrzv16n	70	9	grants	grant	NNS
cord-005081-kxrzv16n	70	10	and	and	CC
cord-005081-kxrzv16n	70	11	worked	work	VBD
cord-005081-kxrzv16n	70	12	out	out	RP
cord-005081-kxrzv16n	70	13	programs	program	NNS
cord-005081-kxrzv16n	70	14	for	for	IN
cord-005081-kxrzv16n	70	15	developing	develop	VBG
cord-005081-kxrzv16n	70	16	novel	novel	JJ
cord-005081-kxrzv16n	70	17	technologies	technology	NNS
cord-005081-kxrzv16n	70	18	and	and	CC
cord-005081-kxrzv16n	70	19	vaccine	vaccine	NN
cord-005081-kxrzv16n	70	20	preparations	preparation	NNS
cord-005081-kxrzv16n	70	21	with	with	IN
cord-005081-kxrzv16n	70	22	improved	improved	JJ
cord-005081-kxrzv16n	70	23	qualities	quality	NNS
cord-005081-kxrzv16n	70	24	:	:	:
cord-005081-kxrzv16n	70	25	a	a	DT
cord-005081-kxrzv16n	70	26	new	new	JJ
cord-005081-kxrzv16n	70	27	generation	generation	NN
cord-005081-kxrzv16n	70	28	of	of	IN
cord-005081-kxrzv16n	70	29	LAIV	LAIV	NNP
cord-005081-kxrzv16n	70	30	,	,	,
cord-005081-kxrzv16n	70	31	that	that	RB
cord-005081-kxrzv16n	70	32	is	is	RB
cord-005081-kxrzv16n	70	33	,	,	,
cord-005081-kxrzv16n	70	34	delNS1	delNS1	VBG
cord-005081-kxrzv16n	70	35	vaccines	vaccine	NNS
cord-005081-kxrzv16n	70	36	with	with	IN
cord-005081-kxrzv16n	70	37	a	a	DT
cord-005081-kxrzv16n	70	38	limited	limited	JJ
cord-005081-kxrzv16n	70	39	replicative	replicative	JJ
cord-005081-kxrzv16n	70	40	potential	potential	NN
cord-005081-kxrzv16n	70	41	,	,	,
cord-005081-kxrzv16n	70	42	LAIV	LAIV	NNP
cord-005081-kxrzv16n	70	43	with	with	IN
cord-005081-kxrzv16n	70	44	deletions	deletion	NNS
cord-005081-kxrzv16n	70	45	of	of	IN
cord-005081-kxrzv16n	70	46	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	70	47	factors	factor	NNS
cord-005081-kxrzv16n	70	48	in	in	IN
cord-005081-kxrzv16n	70	49	genes	gene	NNS
cord-005081-kxrzv16n	70	50	,	,	,
cord-005081-kxrzv16n	70	51	latest	late	JJS
cord-005081-kxrzv16n	70	52	variations	variation	NNS
cord-005081-kxrzv16n	70	53	of	of	IN
cord-005081-kxrzv16n	70	54	subunit	subunit	NN
cord-005081-kxrzv16n	70	55	vaccines	vaccine	NNS
cord-005081-kxrzv16n	70	56	enhanced	enhance	VBN
cord-005081-kxrzv16n	70	57	by	by	IN
cord-005081-kxrzv16n	70	58	adju	adju	NNP
cord-005081-kxrzv16n	70	59	vants	vants	NNP
cord-005081-kxrzv16n	70	60	,	,	,
cord-005081-kxrzv16n	70	61	and	and	CC
cord-005081-kxrzv16n	70	62	capsid	capsid	NN
cord-005081-kxrzv16n	70	63	nanovaccines	nanovaccines	NNP
cord-005081-kxrzv16n	70	64	and	and	CC
cord-005081-kxrzv16n	70	65	nanovaccines	nanovaccines	NNP
cord-005081-kxrzv16n	70	66	based	base	VBN
cord-005081-kxrzv16n	70	67	on	on	IN
cord-005081-kxrzv16n	70	68	inactivated	inactivate	VBN
cord-005081-kxrzv16n	70	69	viruses	virus	NNS
cord-005081-kxrzv16n	70	70	and	and	CC
cord-005081-kxrzv16n	70	71	virus	virus	NN
cord-005081-kxrzv16n	70	72	like	like	IN
cord-005081-kxrzv16n	70	73	particles	particle	NNS
cord-005081-kxrzv16n	70	74	[	[	-LRB-
cord-005081-kxrzv16n	70	75	14	14	CD
cord-005081-kxrzv16n	70	76	]	]	-RRB-
cord-005081-kxrzv16n	70	77	.	.	.
cord-005081-kxrzv16n	71	1	What	what	WP
cord-005081-kxrzv16n	71	2	are	be	VBP
cord-005081-kxrzv16n	71	3	basic	basic	JJ
cord-005081-kxrzv16n	71	4	prospects	prospect	NNS
cord-005081-kxrzv16n	71	5	opening	open	VBG
cord-005081-kxrzv16n	71	6	before	before	IN
cord-005081-kxrzv16n	71	7	the	the	DT
cord-005081-kxrzv16n	71	8	vac	vac	NNP
cord-005081-kxrzv16n	71	9	cines	cines	NNP
cord-005081-kxrzv16n	71	10	constructed	construct	VBD
cord-005081-kxrzv16n	71	11	using	use	VBG
cord-005081-kxrzv16n	71	12	state	state	NN
cord-005081-kxrzv16n	71	13	of	of	IN
cord-005081-kxrzv16n	71	14	the	the	DT
cord-005081-kxrzv16n	71	15	art	art	NN
cord-005081-kxrzv16n	71	16	genetic	genetic	JJ
cord-005081-kxrzv16n	71	17	engi	engi	NNP
cord-005081-kxrzv16n	71	18	neering	neering	NNP
cord-005081-kxrzv16n	71	19	techniques	technique	NNS
cord-005081-kxrzv16n	71	20	?	?	.
cord-005081-kxrzv16n	72	1	Using	use	VBG
cord-005081-kxrzv16n	72	2	the	the	DT
cord-005081-kxrzv16n	72	3	Reverse	Reverse	NNP
cord-005081-kxrzv16n	72	4	Genetics	Genetics	NNP
cord-005081-kxrzv16n	72	5	Technique	technique	NN
cord-005081-kxrzv16n	73	1	The	the	DT
cord-005081-kxrzv16n	73	2	genome	genome	NN
cord-005081-kxrzv16n	73	3	of	of	IN
cord-005081-kxrzv16n	73	4	influenza	influenza	NN
cord-005081-kxrzv16n	73	5	type	type	NN
cord-005081-kxrzv16n	73	6	A	a	NN
cord-005081-kxrzv16n	73	7	viruses	virus	NNS
cord-005081-kxrzv16n	73	8	consists	consist	VBZ
cord-005081-kxrzv16n	73	9	of	of	IN
cord-005081-kxrzv16n	73	10	8	8	CD
cord-005081-kxrzv16n	73	11	segments	segment	NNS
cord-005081-kxrzv16n	73	12	encoding	encode	VBG
cord-005081-kxrzv16n	73	13	11	11	CD
cord-005081-kxrzv16n	73	14	genes	gene	NNS
cord-005081-kxrzv16n	73	15	(	(	-LRB-
cord-005081-kxrzv16n	73	16	Table	table	NN
cord-005081-kxrzv16n	73	17	2	2	CD
cord-005081-kxrzv16n	73	18	)	)	-RRB-
cord-005081-kxrzv16n	73	19	.	.	.
cord-005081-kxrzv16n	74	1	Vaccines	vaccine	NNS
cord-005081-kxrzv16n	74	2	against	against	IN
cord-005081-kxrzv16n	74	3	especially	especially	RB
cord-005081-kxrzv16n	74	4	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	74	5	strains	strain	NNS
cord-005081-kxrzv16n	74	6	of	of	IN
cord-005081-kxrzv16n	74	7	influenza	influenza	NN
cord-005081-kxrzv16n	74	8	viruses	virus	NNS
cord-005081-kxrzv16n	74	9	are	be	VBP
cord-005081-kxrzv16n	74	10	particularly	particularly	RB
cord-005081-kxrzv16n	74	11	difficult	difficult	JJ
cord-005081-kxrzv16n	74	12	to	to	TO
cord-005081-kxrzv16n	74	13	develop	develop	VB
cord-005081-kxrzv16n	74	14	,	,	,
cord-005081-kxrzv16n	74	15	since	since	IN
cord-005081-kxrzv16n	74	16	the	the	DT
cord-005081-kxrzv16n	74	17	conventional	conventional	JJ
cord-005081-kxrzv16n	74	18	approaches	approach	NNS
cord-005081-kxrzv16n	74	19	,	,	,
cord-005081-kxrzv16n	74	20	based	base	VBN
cord-005081-kxrzv16n	74	21	on	on	IN
cord-005081-kxrzv16n	74	22	the	the	DT
cord-005081-kxrzv16n	74	23	reas	reas	JJ
cord-005081-kxrzv16n	74	24	sortment	sortment	NN
cord-005081-kxrzv16n	74	25	of	of	IN
cord-005081-kxrzv16n	74	26	"	"	``
cord-005081-kxrzv16n	74	27	wild	wild	JJ
cord-005081-kxrzv16n	74	28	"	"	''
cord-005081-kxrzv16n	74	29	isolates	isolate	NNS
cord-005081-kxrzv16n	74	30	(	(	-LRB-
cord-005081-kxrzv16n	74	31	epidemiologically	epidemiologically	RB
cord-005081-kxrzv16n	74	32	impor	impor	JJ
cord-005081-kxrzv16n	74	33	tant	tant	FW
cord-005081-kxrzv16n	74	34	viruses	virus	NNS
cord-005081-kxrzv16n	74	35	)	)	-RRB-
cord-005081-kxrzv16n	74	36	and	and	CC
cord-005081-kxrzv16n	74	37	donors	donor	NNS
cord-005081-kxrzv16n	74	38	of	of	IN
cord-005081-kxrzv16n	74	39	attenuation	attenuation	NN
cord-005081-kxrzv16n	74	40	,	,	,
cord-005081-kxrzv16n	74	41	practically	practically	RB
cord-005081-kxrzv16n	74	42	do	do	VBP
cord-005081-kxrzv16n	74	43	not	not	RB
cord-005081-kxrzv16n	74	44	work	work	VB
cord-005081-kxrzv16n	74	45	for	for	IN
cord-005081-kxrzv16n	74	46	obtaining	obtain	VBG
cord-005081-kxrzv16n	74	47	this	this	DT
cord-005081-kxrzv16n	74	48	type	type	NN
cord-005081-kxrzv16n	74	49	of	of	IN
cord-005081-kxrzv16n	74	50	candidate	candidate	NN
cord-005081-kxrzv16n	74	51	vaccine	vaccine	NN
cord-005081-kxrzv16n	74	52	strains	strain	NNS
cord-005081-kxrzv16n	74	53	.	.	.
cord-005081-kxrzv16n	75	1	Usually	usually	RB
cord-005081-kxrzv16n	75	2	,	,	,
cord-005081-kxrzv16n	75	3	in	in	IN
cord-005081-kxrzv16n	75	4	reassortment	reassortment	NN
cord-005081-kxrzv16n	75	5	,	,	,
cord-005081-kxrzv16n	75	6	the	the	DT
cord-005081-kxrzv16n	75	7	genes	gene	NNS
cord-005081-kxrzv16n	75	8	that	that	WDT
cord-005081-kxrzv16n	75	9	encode	encode	VBP
cord-005081-kxrzv16n	75	10	surface	surface	NN
cord-005081-kxrzv16n	75	11	antigens	antigen	NNS
cord-005081-kxrzv16n	75	12	in	in	IN
cord-005081-kxrzv16n	75	13	the	the	DT
cord-005081-kxrzv16n	75	14	donor	donor	NN
cord-005081-kxrzv16n	75	15	are	be	VBP
cord-005081-kxrzv16n	75	16	replaced	replace	VBN
cord-005081-kxrzv16n	75	17	by	by	IN
cord-005081-kxrzv16n	75	18	HA	HA	NNP
cord-005081-kxrzv16n	75	19	and	and	CC
cord-005081-kxrzv16n	75	20	neuraminidase	neuraminidase	NN
cord-005081-kxrzv16n	75	21	of	of	IN
cord-005081-kxrzv16n	75	22	the	the	DT
cord-005081-kxrzv16n	75	23	epidemic	epidemic	NN
cord-005081-kxrzv16n	75	24	's	's	POS
cord-005081-kxrzv16n	75	25	virus	virus	NN
cord-005081-kxrzv16n	75	26	.	.	.
cord-005081-kxrzv16n	76	1	A	a	DT
cord-005081-kxrzv16n	76	2	can	can	MD
cord-005081-kxrzv16n	76	3	didate	didate	VB
cord-005081-kxrzv16n	76	4	vaccine	vaccine	NN
cord-005081-kxrzv16n	76	5	strain	strain	NN
cord-005081-kxrzv16n	76	6	is	be	VBZ
cord-005081-kxrzv16n	76	7	unable	unable	JJ
cord-005081-kxrzv16n	76	8	to	to	TO
cord-005081-kxrzv16n	76	9	cause	cause	VB
cord-005081-kxrzv16n	76	10	a	a	DT
cord-005081-kxrzv16n	76	11	disease	disease	NN
cord-005081-kxrzv16n	76	12	but	but	CC
cord-005081-kxrzv16n	76	13	in	in	IN
cord-005081-kxrzv16n	76	14	immunization	immunization	NN
cord-005081-kxrzv16n	76	15	it	-PRON-	PRP
cord-005081-kxrzv16n	76	16	supports	support	VBZ
cord-005081-kxrzv16n	76	17	the	the	DT
cord-005081-kxrzv16n	76	18	development	development	NN
cord-005081-kxrzv16n	76	19	of	of	IN
cord-005081-kxrzv16n	76	20	immu	immu	NNP
cord-005081-kxrzv16n	76	21	 	 	_SP
cord-005081-kxrzv16n	77	1	The	the	DT
cord-005081-kxrzv16n	77	2	open	open	JJ
cord-005081-kxrzv16n	77	3	reading	reading	NN
cord-005081-kxrzv16n	77	4	frame	frame	NN
cord-005081-kxrzv16n	77	5	in	in	IN
cord-005081-kxrzv16n	77	6	the	the	DT
cord-005081-kxrzv16n	77	7	PB1	pb1	JJ
cord-005081-kxrzv16n	77	8	PB1	PB1	NNP
cord-005081-kxrzv16n	77	9	F2	F2	NNP
cord-005081-kxrzv16n	77	10	gene	gene	NN
cord-005081-kxrzv16n	77	11	,	,	,
cord-005081-kxrzv16n	77	12	which	which	WDT
cord-005081-kxrzv16n	77	13	encodes	encode	VBZ
cord-005081-kxrzv16n	77	14	the	the	DT
cord-005081-kxrzv16n	77	15	amphiphilic	amphiphilic	JJ
cord-005081-kxrzv16n	77	16	transmembrane	transmembrane	NN
cord-005081-kxrzv16n	77	17	protein	protein	NN
cord-005081-kxrzv16n	77	18	with	with	IN
cord-005081-kxrzv16n	77	19	signaling	signal	VBG
cord-005081-kxrzv16n	77	20	peptide	peptide	NN
cord-005081-kxrzv16n	77	21	of	of	IN
cord-005081-kxrzv16n	77	22	mitochondrial	mitochondrial	JJ
cord-005081-kxrzv16n	77	23	local	local	JJ
cord-005081-kxrzv16n	77	24	ization	ization	NN
cord-005081-kxrzv16n	77	25	.	.	.
cord-005081-kxrzv16n	78	1	(	(	-LRB-
cord-005081-kxrzv16n	78	2	3	3	LS
cord-005081-kxrzv16n	78	3	)	)	-RRB-
cord-005081-kxrzv16n	78	4	Mutations	mutation	NNS
cord-005081-kxrzv16n	78	5	in	in	IN
cord-005081-kxrzv16n	78	6	the	the	DT
cord-005081-kxrzv16n	78	7	PB2	PB2	NNP
cord-005081-kxrzv16n	78	8	gene	gene	NN
cord-005081-kxrzv16n	78	9	(	(	-LRB-
cord-005081-kxrzv16n	78	10	polymerase	polymerase	NN
cord-005081-kxrzv16n	78	11	com	com	NN
cord-005081-kxrzv16n	78	12	plex	plex	NNP
cord-005081-kxrzv16n	78	13	)	)	-RRB-
cord-005081-kxrzv16n	78	14	.	.	.
cord-005081-kxrzv16n	79	1	(	(	-LRB-
cord-005081-kxrzv16n	79	2	4	4	LS
cord-005081-kxrzv16n	79	3	)	)	-RRB-
cord-005081-kxrzv16n	79	4	Mutations	mutation	NNS
cord-005081-kxrzv16n	79	5	in	in	IN
cord-005081-kxrzv16n	79	6	the	the	DT
cord-005081-kxrzv16n	79	7	gene	gene	NN
cord-005081-kxrzv16n	79	8	encoding	encode	VBG
cord-005081-kxrzv16n	79	9	the	the	DT
cord-005081-kxrzv16n	79	10	nonstruc	nonstruc	NNP
cord-005081-kxrzv16n	79	11	tural	tural	NNP
cord-005081-kxrzv16n	79	12	NS1protein	NS1protein	NNP
cord-005081-kxrzv16n	79	13	-	-	:
cord-005081-kxrzv16n	79	14	an	an	DT
cord-005081-kxrzv16n	79	15	antagonist	antagonist	NN
cord-005081-kxrzv16n	79	16	of	of	IN
cord-005081-kxrzv16n	79	17	the	the	DT
cord-005081-kxrzv16n	79	18	interferon	interferon	NN
cord-005081-kxrzv16n	79	19	system	system	NN
cord-005081-kxrzv16n	79	20	of	of	IN
cord-005081-kxrzv16n	79	21	the	the	DT
cord-005081-kxrzv16n	79	22	first	first	JJ
cord-005081-kxrzv16n	79	23	type	type	NN
cord-005081-kxrzv16n	79	24	.	.	.
cord-005081-kxrzv16n	80	1	(	(	-LRB-
cord-005081-kxrzv16n	80	2	5	5	LS
cord-005081-kxrzv16n	80	3	)	)	-RRB-
cord-005081-kxrzv16n	80	4	Mutations	mutation	NNS
cord-005081-kxrzv16n	80	5	in	in	IN
cord-005081-kxrzv16n	80	6	the	the	DT
cord-005081-kxrzv16n	80	7	M2	M2	NNP
cord-005081-kxrzv16n	80	8	protein	protein	NN
cord-005081-kxrzv16n	80	9	gene	gene	NN
cord-005081-kxrzv16n	80	10	that	that	WDT
cord-005081-kxrzv16n	80	11	controls	control	VBZ
cord-005081-kxrzv16n	80	12	key	key	JJ
cord-005081-kxrzv16n	80	13	stages	stage	NNS
cord-005081-kxrzv16n	80	14	of	of	IN
cord-005081-kxrzv16n	80	15	a	a	DT
cord-005081-kxrzv16n	80	16	reproductive	reproductive	JJ
cord-005081-kxrzv16n	80	17	cycle	cycle	NN
cord-005081-kxrzv16n	80	18	through	through	IN
cord-005081-kxrzv16n	80	19	the	the	DT
cord-005081-kxrzv16n	80	20	so	so	RB
cord-005081-kxrzv16n	80	21	called	call	VBN
cord-005081-kxrzv16n	80	22	proton	proton	NN
cord-005081-kxrzv16n	80	23	pump	pump	NN
cord-005081-kxrzv16n	80	24	and	and	CC
cord-005081-kxrzv16n	80	25	drug	drug	NN
cord-005081-kxrzv16n	80	26	resistance	resistance	NN
cord-005081-kxrzv16n	80	27	to	to	IN
cord-005081-kxrzv16n	80	28	Rimantadine	Rimantadine	NNP
cord-005081-kxrzv16n	80	29	.	.	.
cord-005081-kxrzv16n	81	1	As	as	IN
cord-005081-kxrzv16n	81	2	was	be	VBD
cord-005081-kxrzv16n	81	3	mentioned	mention	VBN
cord-005081-kxrzv16n	81	4	,	,	,
cord-005081-kxrzv16n	81	5	to	to	TO
cord-005081-kxrzv16n	81	6	construct	construct	VB
cord-005081-kxrzv16n	81	7	a	a	DT
cord-005081-kxrzv16n	81	8	new	new	JJ
cord-005081-kxrzv16n	81	9	vaccine	vaccine	NN
cord-005081-kxrzv16n	81	10	,	,	,
cord-005081-kxrzv16n	81	11	the	the	DT
cord-005081-kxrzv16n	81	12	surface	surface	NN
cord-005081-kxrzv16n	81	13	antigens	antigen	NNS
cord-005081-kxrzv16n	81	14	,	,	,
cord-005081-kxrzv16n	81	15	primarily	primarily	RB
cord-005081-kxrzv16n	81	16	HA	HA	NNP
cord-005081-kxrzv16n	81	17	,	,	,
cord-005081-kxrzv16n	81	18	should	should	MD
cord-005081-kxrzv16n	81	19	be	be	VB
cord-005081-kxrzv16n	81	20	replaced	replace	VBN
cord-005081-kxrzv16n	81	21	.	.	.
cord-005081-kxrzv16n	82	1	Replacing	replace	VBG
cord-005081-kxrzv16n	82	2	HA	HA	NNP
cord-005081-kxrzv16n	82	3	in	in	IN
cord-005081-kxrzv16n	82	4	the	the	DT
cord-005081-kxrzv16n	82	5	donor	donor	NN
cord-005081-kxrzv16n	82	6	of	of	IN
cord-005081-kxrzv16n	82	7	attenuation	attenuation	NN
cord-005081-kxrzv16n	82	8	by	by	IN
cord-005081-kxrzv16n	82	9	the	the	DT
cord-005081-kxrzv16n	82	10	HA	HA	NNP
cord-005081-kxrzv16n	82	11	of	of	IN
cord-005081-kxrzv16n	82	12	the	the	DT
cord-005081-kxrzv16n	82	13	avian	avian	JJ
cord-005081-kxrzv16n	82	14	virus	virus	NN
cord-005081-kxrzv16n	82	15	A	a	NN
cord-005081-kxrzv16n	83	1	(	(	-LRB-
cord-005081-kxrzv16n	83	2	H5N1	H5N1	NNP
cord-005081-kxrzv16n	83	3	)	)	-RRB-
cord-005081-kxrzv16n	83	4	will	will	MD
cord-005081-kxrzv16n	83	5	lead	lead	VB
cord-005081-kxrzv16n	83	6	to	to	IN
cord-005081-kxrzv16n	83	7	a	a	DT
cord-005081-kxrzv16n	83	8	transference	transference	NN
cord-005081-kxrzv16n	83	9	of	of	IN
cord-005081-kxrzv16n	83	10	the	the	DT
cord-005081-kxrzv16n	83	11	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	83	12	determinant	determinant	NN
cord-005081-kxrzv16n	83	13	.	.	.
cord-005081-kxrzv16n	84	1	A	a	DT
cord-005081-kxrzv16n	84	2	candidate	candidate	NN
cord-005081-kxrzv16n	84	3	vaccine	vaccine	NN
cord-005081-kxrzv16n	84	4	strain	strain	NN
cord-005081-kxrzv16n	84	5	should	should	MD
cord-005081-kxrzv16n	84	6	contain	contain	VB
cord-005081-kxrzv16n	84	7	at	at	IN
cord-005081-kxrzv16n	84	8	least	least	RBS
cord-005081-kxrzv16n	84	9	one	one	CD
cord-005081-kxrzv16n	84	10	sign	sign	NN
cord-005081-kxrzv16n	84	11	of	of	IN
cord-005081-kxrzv16n	84	12	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	84	13	.	.	.
cord-005081-kxrzv16n	85	1	To	to	TO
cord-005081-kxrzv16n	85	2	obtain	obtain	VB
cord-005081-kxrzv16n	85	3	a	a	DT
cord-005081-kxrzv16n	85	4	safe	safe	JJ
cord-005081-kxrzv16n	85	5	vaccine	vaccine	NN
cord-005081-kxrzv16n	85	6	,	,	,
cord-005081-kxrzv16n	85	7	this	this	DT
cord-005081-kxrzv16n	85	8	determinant	determinant	NN
cord-005081-kxrzv16n	85	9	should	should	MD
cord-005081-kxrzv16n	85	10	be	be	VB
cord-005081-kxrzv16n	85	11	removed	remove	VBN
cord-005081-kxrzv16n	85	12	.	.	.
cord-005081-kxrzv16n	86	1	However	however	RB
cord-005081-kxrzv16n	86	2	,	,	,
cord-005081-kxrzv16n	86	3	this	this	DT
cord-005081-kxrzv16n	86	4	is	be	VBZ
cord-005081-kxrzv16n	86	5	impossible	impossible	JJ
cord-005081-kxrzv16n	86	6	to	to	TO
cord-005081-kxrzv16n	86	7	realize	realize	VB
cord-005081-kxrzv16n	86	8	at	at	IN
cord-005081-kxrzv16n	86	9	the	the	DT
cord-005081-kxrzv16n	86	10	RNA	RNA	NNP
cord-005081-kxrzv16n	86	11	level	level	NN
cord-005081-kxrzv16n	86	12	.	.	.
cord-005081-kxrzv16n	87	1	The	the	DT
cord-005081-kxrzv16n	87	2	viral	viral	JJ
cord-005081-kxrzv16n	87	3	genome	genome	NN
cord-005081-kxrzv16n	87	4	should	should	MD
cord-005081-kxrzv16n	87	5	be	be	VB
cord-005081-kxrzv16n	87	6	converted	convert	VBN
cord-005081-kxrzv16n	87	7	to	to	IN
cord-005081-kxrzv16n	87	8	the	the	DT
cord-005081-kxrzv16n	87	9	DNA	dna	NN
cord-005081-kxrzv16n	87	10	form	form	NN
cord-005081-kxrzv16n	87	11	.	.	.
cord-005081-kxrzv16n	88	1	This	this	DT
cord-005081-kxrzv16n	88	2	technique	technique	NN
cord-005081-kxrzv16n	88	3	was	be	VBD
cord-005081-kxrzv16n	88	4	realized	realize	VBN
cord-005081-kxrzv16n	88	5	for	for	IN
cord-005081-kxrzv16n	88	6	the	the	DT
cord-005081-kxrzv16n	88	7	first	first	JJ
cord-005081-kxrzv16n	88	8	time	time	NN
cord-005081-kxrzv16n	88	9	by	by	IN
cord-005081-kxrzv16n	88	10	D.	D.	NNP
cord-005081-kxrzv16n	88	11	Baltimore	Baltimore	NNP
cord-005081-kxrzv16n	88	12	,	,	,
cord-005081-kxrzv16n	88	13	a	a	DT
cord-005081-kxrzv16n	88	14	Nobel	Nobel	NNP
cord-005081-kxrzv16n	88	15	Prize	Prize	NNP
cord-005081-kxrzv16n	88	16	laureate	laureate	NN
cord-005081-kxrzv16n	88	17	,	,	,
cord-005081-kxrzv16n	88	18	for	for	IN
cord-005081-kxrzv16n	88	19	the	the	DT
cord-005081-kxrzv16n	88	20	polio	polio	NN
cord-005081-kxrzv16n	88	21	virus	virus	NN
cord-005081-kxrzv16n	88	22	RNA	RNA	NNP
cord-005081-kxrzv16n	88	23	more	more	JJR
cord-005081-kxrzv16n	88	24	than	than	IN
cord-005081-kxrzv16n	88	25	20	20	CD
cord-005081-kxrzv16n	88	26	years	year	NNS
cord-005081-kxrzv16n	88	27	ago	ago	RB
cord-005081-kxrzv16n	88	28	;	;	,
cord-005081-kxrzv16n	88	29	relative	relative	JJ
cord-005081-kxrzv16n	88	30	to	to	IN
cord-005081-kxrzv16n	88	31	the	the	DT
cord-005081-kxrzv16n	88	32	RNA	RNA	NNP
cord-005081-kxrzv16n	88	33	containing	contain	VBG
cord-005081-kxrzv16n	88	34	influenza	influenza	NN
cord-005081-kxrzv16n	88	35	viruses	virus	NNS
cord-005081-kxrzv16n	88	36	,	,	,
cord-005081-kxrzv16n	88	37	this	this	DT
cord-005081-kxrzv16n	88	38	approach	approach	NN
cord-005081-kxrzv16n	88	39	was	be	VBD
cord-005081-kxrzv16n	88	40	termed	term	VBN
cord-005081-kxrzv16n	88	41	"	"	``
cord-005081-kxrzv16n	88	42	reverse	reverse	JJ
cord-005081-kxrzv16n	88	43	genetics	genetic	NNS
cord-005081-kxrzv16n	88	44	"	"	''
cord-005081-kxrzv16n	89	1	(	(	-LRB-
cord-005081-kxrzv16n	89	2	in	in	IN
cord-005081-kxrzv16n	89	3	nature	nature	NN
cord-005081-kxrzv16n	89	4	this	this	DT
cord-005081-kxrzv16n	89	5	process	process	NN
cord-005081-kxrzv16n	89	6	is	be	VBZ
cord-005081-kxrzv16n	89	7	realized	realize	VBN
cord-005081-kxrzv16n	89	8	by	by	IN
cord-005081-kxrzv16n	89	9	reverse	reverse	JJ
cord-005081-kxrzv16n	89	10	transcriptase	transcriptase	NN
cord-005081-kxrzv16n	89	11	)	)	-RRB-
cord-005081-kxrzv16n	89	12	and	and	CC
cord-005081-kxrzv16n	89	13	patented	patent	VBN
cord-005081-kxrzv16n	89	14	[	[	-LRB-
cord-005081-kxrzv16n	89	15	14	14	CD
cord-005081-kxrzv16n	89	16	,	,	,
cord-005081-kxrzv16n	89	17	[	[	-LRB-
cord-005081-kxrzv16n	89	18	17	17	CD
cord-005081-kxrzv16n	89	19	]	]	-RRB-
cord-005081-kxrzv16n	89	20	[	[	-LRB-
cord-005081-kxrzv16n	89	21	18	18	CD
cord-005081-kxrzv16n	89	22	]	]	-RRB-
cord-005081-kxrzv16n	89	23	[	[	-LRB-
cord-005081-kxrzv16n	89	24	19	19	CD
cord-005081-kxrzv16n	89	25	]	]	-RRB-
cord-005081-kxrzv16n	89	26	[	[	-LRB-
cord-005081-kxrzv16n	89	27	20	20	CD
cord-005081-kxrzv16n	89	28	]	]	-RRB-
cord-005081-kxrzv16n	89	29	[	[	-LRB-
cord-005081-kxrzv16n	89	30	21	21	CD
cord-005081-kxrzv16n	89	31	]	]	-RRB-
cord-005081-kxrzv16n	89	32	.	.	.
cord-005081-kxrzv16n	90	1	Several	several	JJ
cord-005081-kxrzv16n	90	2	research	research	NN
cord-005081-kxrzv16n	90	3	teams	team	NNS
cord-005081-kxrzv16n	90	4	throughout	throughout	IN
cord-005081-kxrzv16n	90	5	the	the	DT
cord-005081-kxrzv16n	90	6	world	world	NN
cord-005081-kxrzv16n	90	7	construct	construct	VBP
cord-005081-kxrzv16n	90	8	viruses	virus	NNS
cord-005081-kxrzv16n	90	9	using	use	VBG
cord-005081-kxrzv16n	90	10	the	the	DT
cord-005081-kxrzv16n	90	11	removal	removal	NN
cord-005081-kxrzv16n	90	12	technique	technique	NN
cord-005081-kxrzv16n	90	13	at	at	IN
cord-005081-kxrzv16n	90	14	the	the	DT
cord-005081-kxrzv16n	90	15	level	level	NN
cord-005081-kxrzv16n	90	16	of	of	IN
cord-005081-kxrzv16n	90	17	the	the	DT
cord-005081-kxrzv16n	90	18	DNA	dna	NN
cord-005081-kxrzv16n	90	19	sequences	sequence	NNS
cord-005081-kxrzv16n	90	20	encoding	encode	VBG
cord-005081-kxrzv16n	90	21	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	90	22	sites	site	NNS
cord-005081-kxrzv16n	90	23	(	(	-LRB-
cord-005081-kxrzv16n	90	24	the	the	DT
cord-005081-kxrzv16n	90	25	HA	HA	NNP
cord-005081-kxrzv16n	90	26	cleavage	cleavage	NN
cord-005081-kxrzv16n	90	27	site	site	NN
cord-005081-kxrzv16n	90	28	in	in	IN
cord-005081-kxrzv16n	90	29	the	the	DT
cord-005081-kxrzv16n	90	30	case	case	NN
cord-005081-kxrzv16n	90	31	of	of	IN
cord-005081-kxrzv16n	90	32	avian	avian	JJ
cord-005081-kxrzv16n	90	33	influ	influ	NNP
cord-005081-kxrzv16n	90	34	enza	enza	NNP
cord-005081-kxrzv16n	90	35	viruses	viruses	NNPS
cord-005081-kxrzv16n	90	36	)	)	-RRB-
cord-005081-kxrzv16n	90	37	.	.	.
cord-005081-kxrzv16n	91	1	Six	six	CD
cord-005081-kxrzv16n	91	2	basic	basic	JJ
cord-005081-kxrzv16n	91	3	plasmid	plasmid	NN
cord-005081-kxrzv16n	91	4	DNAs	dna	NNS
cord-005081-kxrzv16n	91	5	encode	encode	VBP
cord-005081-kxrzv16n	91	6	internal	internal	JJ
cord-005081-kxrzv16n	91	7	genes	gene	NNS
cord-005081-kxrzv16n	91	8	of	of	IN
cord-005081-kxrzv16n	91	9	a	a	DT
cord-005081-kxrzv16n	91	10	known	know	VBN
cord-005081-kxrzv16n	91	11	donor	donor	NN
cord-005081-kxrzv16n	91	12	of	of	IN
cord-005081-kxrzv16n	91	13	attenuation	attenuation	NN
cord-005081-kxrzv16n	91	14	.	.	.
cord-005081-kxrzv16n	92	1	Constructing	construct	VBG
cord-005081-kxrzv16n	92	2	plasmids	plasmid	NNS
cord-005081-kxrzv16n	92	3	is	be	VBZ
cord-005081-kxrzv16n	92	4	a	a	DT
cord-005081-kxrzv16n	92	5	specific	specific	JJ
cord-005081-kxrzv16n	92	6	process	process	NN
cord-005081-kxrzv16n	92	7	,	,	,
cord-005081-kxrzv16n	92	8	since	since	IN
cord-005081-kxrzv16n	92	9	,	,	,
cord-005081-kxrzv16n	92	10	in	in	IN
cord-005081-kxrzv16n	92	11	each	each	DT
cord-005081-kxrzv16n	92	12	plasmids	plasmid	NNS
cord-005081-kxrzv16n	92	13	,	,	,
cord-005081-kxrzv16n	92	14	bidirectional	bidirectional	JJ
cord-005081-kxrzv16n	92	15	transcription	transcription	NN
cord-005081-kxrzv16n	92	16	is	be	VBZ
cord-005081-kxrzv16n	92	17	provided	provide	VBN
cord-005081-kxrzv16n	92	18	for	for	IN
cord-005081-kxrzv16n	92	19	the	the	DT
cord-005081-kxrzv16n	92	20	virus	virus	NN
cord-005081-kxrzv16n	93	1	specific	specific	JJ
cord-005081-kxrzv16n	93	2	mRNA	mRNA	NNP
cord-005081-kxrzv16n	93	3	and	and	CC
cord-005081-kxrzv16n	93	4	the	the	DT
cord-005081-kxrzv16n	93	5	complimentary	complimentary	JJ
cord-005081-kxrzv16n	93	6	virion	virion	NN
cord-005081-kxrzv16n	93	7	RNA	RNA	NNP
cord-005081-kxrzv16n	93	8	with	with	IN
cord-005081-kxrzv16n	93	9	a	a	DT
cord-005081-kxrzv16n	93	10	negative	negative	JJ
cord-005081-kxrzv16n	93	11	polarity	polarity	NN
cord-005081-kxrzv16n	93	12	-	-	:
cord-005081-kxrzv16n	93	13	a	a	DT
cord-005081-kxrzv16n	93	14	necessary	necessary	JJ
cord-005081-kxrzv16n	93	15	factor	factor	NN
cord-005081-kxrzv16n	93	16	for	for	IN
cord-005081-kxrzv16n	93	17	the	the	DT
cord-005081-kxrzv16n	93	18	synthesis	synthesis	NN
cord-005081-kxrzv16n	93	19	of	of	IN
cord-005081-kxrzv16n	93	20	virus	virus	NN
cord-005081-kxrzv16n	93	21	specific	specific	JJ
cord-005081-kxrzv16n	93	22	proteins	protein	NNS
cord-005081-kxrzv16n	93	23	and	and	CC
cord-005081-kxrzv16n	93	24	accumulating	accumulate	VBG
cord-005081-kxrzv16n	93	25	genomic	genomic	JJ
cord-005081-kxrzv16n	93	26	fragments	fragment	NNS
cord-005081-kxrzv16n	93	27	when	when	WRB
cord-005081-kxrzv16n	93	28	obtaining	obtain	VBG
cord-005081-kxrzv16n	93	29	infectious	infectious	JJ
cord-005081-kxrzv16n	93	30	viral	viral	JJ
cord-005081-kxrzv16n	93	31	progeny	progeny	NN
cord-005081-kxrzv16n	93	32	.	.	.
cord-005081-kxrzv16n	94	1	In	in	IN
cord-005081-kxrzv16n	94	2	1973	1973	CD
cord-005081-kxrzv16n	94	3	researchers	researcher	NNS
cord-005081-kxrzv16n	94	4	from	from	IN
cord-005081-kxrzv16n	94	5	the	the	DT
cord-005081-kxrzv16n	94	6	National	National	NNP
cord-005081-kxrzv16n	94	7	Institute	Institute	NNP
cord-005081-kxrzv16n	94	8	for	for	IN
cord-005081-kxrzv16n	94	9	Biological	Biological	NNP
cord-005081-kxrzv16n	94	10	Standards	Standards	NNPS
cord-005081-kxrzv16n	94	11	and	and	CC
cord-005081-kxrzv16n	94	12	Control	Control	NNP
cord-005081-kxrzv16n	94	13	(	(	-LRB-
cord-005081-kxrzv16n	94	14	NIBSC	NIBSC	NNP
cord-005081-kxrzv16n	94	15	)	)	-RRB-
cord-005081-kxrzv16n	94	16	,	,	,
cord-005081-kxrzv16n	94	17	London	London	NNP
cord-005081-kxrzv16n	94	18	,	,	,
cord-005081-kxrzv16n	94	19	Common	Common	NNP
cord-005081-kxrzv16n	94	20	Cold	Cold	NNP
cord-005081-kxrzv16n	94	21	Research	Research	NNP
cord-005081-kxrzv16n	94	22	Unit	Unit	NNP
cord-005081-kxrzv16n	94	23	(	(	-LRB-
cord-005081-kxrzv16n	94	24	MRC	MRC	NNP
cord-005081-kxrzv16n	94	25	,	,	,
cord-005081-kxrzv16n	94	26	England	England	NNP
cord-005081-kxrzv16n	94	27	,	,	,
cord-005081-kxrzv16n	94	28	Salis	Salis	NNP
cord-005081-kxrzv16n	94	29	bury	bury	VBD
cord-005081-kxrzv16n	94	30	)	)	-RRB-
cord-005081-kxrzv16n	94	31	,	,	,
cord-005081-kxrzv16n	94	32	as	as	RB
cord-005081-kxrzv16n	94	33	well	well	RB
cord-005081-kxrzv16n	94	34	as	as	IN
cord-005081-kxrzv16n	94	35	from	from	IN
cord-005081-kxrzv16n	94	36	the	the	DT
cord-005081-kxrzv16n	94	37	RJC	RJC	NNP
cord-005081-kxrzv16n	94	38	research	research	NN
cord-005081-kxrzv16n	94	39	and	and	CC
cord-005081-kxrzv16n	94	40	production	production	NN
cord-005081-kxrzv16n	94	41	therapeutic	therapeutic	JJ
cord-005081-kxrzv16n	94	42	corporation	corporation	NN
cord-005081-kxrzv16n	94	43	,	,	,
cord-005081-kxrzv16n	94	44	Rixensart	Rixensart	NNP
cord-005081-kxrzv16n	94	45	,	,	,
cord-005081-kxrzv16n	94	46	Belgium	Belgium	NNP
cord-005081-kxrzv16n	94	47	,	,	,
cord-005081-kxrzv16n	94	48	offered	offer	VBD
cord-005081-kxrzv16n	94	49	the	the	DT
cord-005081-kxrzv16n	94	50	A	A	NNP
cord-005081-kxrzv16n	94	51	/	/	SYM
cord-005081-kxrzv16n	94	52	PR/8/34	pr/8/34	CD
cord-005081-kxrzv16n	94	53	strain	strain	NN
cord-005081-kxrzv16n	94	54	as	as	IN
cord-005081-kxrzv16n	94	55	the	the	DT
cord-005081-kxrzv16n	94	56	master	master	NN
cord-005081-kxrzv16n	94	57	donor	donor	NN
cord-005081-kxrzv16n	94	58	for	for	IN
cord-005081-kxrzv16n	94	59	con	con	FW
cord-005081-kxrzv16n	94	60	structing	structe	VBG
cord-005081-kxrzv16n	94	61	influenza	influenza	NN
cord-005081-kxrzv16n	94	62	vaccines	vaccine	NNS
cord-005081-kxrzv16n	94	63	.	.	.
cord-005081-kxrzv16n	95	1	Eight	eight	CD
cord-005081-kxrzv16n	95	2	reassortants	reassortant	NNS
cord-005081-kxrzv16n	95	3	of	of	IN
cord-005081-kxrzv16n	95	4	the	the	DT
cord-005081-kxrzv16n	95	5	influenza	influenza	NN
cord-005081-kxrzv16n	95	6	H1N1	H1N1	NNP
cord-005081-kxrzv16n	95	7	and	and	CC
cord-005081-kxrzv16n	95	8	H3N2	H3N2	NNP
cord-005081-kxrzv16n	95	9	virus	virus	NN
cord-005081-kxrzv16n	95	10	serosubtypes	serosubtype	NNS
cord-005081-kxrzv16n	95	11	were	be	VBD
cord-005081-kxrzv16n	95	12	prepared	prepare	VBN
cord-005081-kxrzv16n	95	13	on	on	IN
cord-005081-kxrzv16n	95	14	the	the	DT
cord-005081-kxrzv16n	95	15	basis	basis	NN
cord-005081-kxrzv16n	95	16	of	of	IN
cord-005081-kxrzv16n	95	17	this	this	DT
cord-005081-kxrzv16n	95	18	donor	donor	NN
cord-005081-kxrzv16n	95	19	and	and	CC
cord-005081-kxrzv16n	95	20	then	then	RB
cord-005081-kxrzv16n	95	21	thor	thor	NNP
cord-005081-kxrzv16n	95	22	oughly	oughly	NNP
cord-005081-kxrzv16n	95	23	tested	test	VBD
cord-005081-kxrzv16n	95	24	in	in	IN
cord-005081-kxrzv16n	95	25	sensitive	sensitive	JJ
cord-005081-kxrzv16n	95	26	subjects	subject	NNS
cord-005081-kxrzv16n	95	27	from	from	IN
cord-005081-kxrzv16n	95	28	different	different	JJ
cord-005081-kxrzv16n	95	29	age	age	NN
cord-005081-kxrzv16n	95	30	groups	group	NNS
cord-005081-kxrzv16n	95	31	at	at	IN
cord-005081-kxrzv16n	95	32	laboratories	laboratory	NNS
cord-005081-kxrzv16n	95	33	in	in	IN
cord-005081-kxrzv16n	95	34	the	the	DT
cord-005081-kxrzv16n	95	35	United	United	NNP
cord-005081-kxrzv16n	95	36	States	States	NNP
cord-005081-kxrzv16n	95	37	,	,	,
cord-005081-kxrzv16n	95	38	West	West	NNP
cord-005081-kxrzv16n	95	39	Europe	Europe	NNP
cord-005081-kxrzv16n	95	40	,	,	,
cord-005081-kxrzv16n	95	41	and	and	CC
cord-005081-kxrzv16n	95	42	Australia	Australia	NNP
cord-005081-kxrzv16n	95	43	.	.	.
cord-005081-kxrzv16n	96	1	The	the	DT
cord-005081-kxrzv16n	96	2	A	A	NNP
cord-005081-kxrzv16n	96	3	/	/	SYM
cord-005081-kxrzv16n	96	4	PR/8/34	pr/8/34	CD
cord-005081-kxrzv16n	96	5	strain	strain	NN
cord-005081-kxrzv16n	96	6	was	be	VBD
cord-005081-kxrzv16n	96	7	offered	offer	VBN
cord-005081-kxrzv16n	96	8	as	as	IN
cord-005081-kxrzv16n	96	9	a	a	DT
cord-005081-kxrzv16n	96	10	donor	donor	NN
cord-005081-kxrzv16n	96	11	of	of	IN
cord-005081-kxrzv16n	96	12	attenuation	attenuation	NN
cord-005081-kxrzv16n	96	13	,	,	,
cord-005081-kxrzv16n	96	14	because	because	IN
cord-005081-kxrzv16n	96	15	the	the	DT
cord-005081-kxrzv16n	96	16	reassor	reassor	NNP
cord-005081-kxrzv16n	96	17	tants	tants	NNP
cord-005081-kxrzv16n	96	18	tested	test	VBD
cord-005081-kxrzv16n	96	19	lacked	lack	VBD
cord-005081-kxrzv16n	96	20	reactogenicity	reactogenicity	NN
cord-005081-kxrzv16n	96	21	and	and	CC
cord-005081-kxrzv16n	96	22	showed	show	VBD
cord-005081-kxrzv16n	96	23	very	very	RB
cord-005081-kxrzv16n	96	24	high	high	JJ
cord-005081-kxrzv16n	96	25	activity	activity	NN
cord-005081-kxrzv16n	96	26	indicators	indicator	NNS
cord-005081-kxrzv16n	96	27	in	in	IN
cord-005081-kxrzv16n	96	28	adults	adult	NNS
cord-005081-kxrzv16n	96	29	and	and	CC
cord-005081-kxrzv16n	96	30	children	child	NNS
cord-005081-kxrzv16n	96	31	(	(	-LRB-
cord-005081-kxrzv16n	96	32	3	3	CD
cord-005081-kxrzv16n	96	33	-	-	SYM
cord-005081-kxrzv16n	96	34	4	4	CD
cord-005081-kxrzv16n	96	35	fold	fold	VB
cord-005081-kxrzv16n	96	36	excess	excess	NN
cord-005081-kxrzv16n	96	37	over	over	IN
cord-005081-kxrzv16n	96	38	the	the	DT
cord-005081-kxrzv16n	96	39	generally	generally	RB
cord-005081-kxrzv16n	96	40	accepted	accept	VBN
cord-005081-kxrzv16n	96	41	minimum	minimum	JJ
cord-005081-kxrzv16n	96	42	pro	pro	JJ
cord-005081-kxrzv16n	96	43	tection	tection	NN
cord-005081-kxrzv16n	96	44	level	level	NN
cord-005081-kxrzv16n	96	45	for	for	IN
cord-005081-kxrzv16n	96	46	humoral	humoral	JJ
cord-005081-kxrzv16n	96	47	antibodies	antibody	NNS
cord-005081-kxrzv16n	96	48	)	)	-RRB-
cord-005081-kxrzv16n	96	49	.	.	.
cord-005081-kxrzv16n	97	1	The	the	DT
cord-005081-kxrzv16n	97	2	reverse	reverse	JJ
cord-005081-kxrzv16n	97	3	genetics	genetics	NN
cord-005081-kxrzv16n	97	4	technique	technique	NN
cord-005081-kxrzv16n	97	5	was	be	VBD
cord-005081-kxrzv16n	97	6	successfully	successfully	RB
cord-005081-kxrzv16n	97	7	applied	apply	VBN
cord-005081-kxrzv16n	97	8	in	in	IN
cord-005081-kxrzv16n	97	9	con	con	NN
cord-005081-kxrzv16n	97	10	structing	structe	VBG
cord-005081-kxrzv16n	97	11	the	the	DT
cord-005081-kxrzv16n	97	12	candidate	candidate	NN
cord-005081-kxrzv16n	97	13	vaccine	vaccine	NN
cord-005081-kxrzv16n	97	14	strains	strain	VBZ
cord-005081-kxrzv16n	97	15	on	on	IN
cord-005081-kxrzv16n	97	16	the	the	DT
cord-005081-kxrzv16n	97	17	basis	basis	NN
cord-005081-kxrzv16n	97	18	of	of	IN
cord-005081-kxrzv16n	97	19	the	the	DT
cord-005081-kxrzv16n	97	20	avian	avian	JJ
cord-005081-kxrzv16n	97	21	flu	flu	NN
cord-005081-kxrzv16n	98	1	H5N1virus	H5N1virus	NNP
cord-005081-kxrzv16n	98	2	isolates	isolate	VBZ
cord-005081-kxrzv16n	98	3	having	have	VBG
cord-005081-kxrzv16n	98	4	the	the	DT
cord-005081-kxrzv16n	98	5	most	most	RBS
cord-005081-kxrzv16n	98	6	important	important	JJ
cord-005081-kxrzv16n	98	7	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	98	8	determinant	determinant	NN
cord-005081-kxrzv16n	98	9	in	in	IN
cord-005081-kxrzv16n	98	10	the	the	DT
cord-005081-kxrzv16n	98	11	HA	HA	NNP
cord-005081-kxrzv16n	98	12	gene	gene	NN
cord-005081-kxrzv16n	98	13	as	as	IN
cord-005081-kxrzv16n	98	14	a	a	DT
cord-005081-kxrzv16n	98	15	cluster	cluster	NN
cord-005081-kxrzv16n	98	16	of	of	IN
cord-005081-kxrzv16n	98	17	residues	residue	NNS
cord-005081-kxrzv16n	98	18	from	from	IN
cord-005081-kxrzv16n	98	19	lysine	lysine	NN
cord-005081-kxrzv16n	98	20	and	and	CC
cord-005081-kxrzv16n	98	21	arginine	arginine	NN
cord-005081-kxrzv16n	98	22	at	at	IN
cord-005081-kxrzv16n	98	23	the	the	DT
cord-005081-kxrzv16n	98	24	site	site	NN
cord-005081-kxrzv16n	98	25	of	of	IN
cord-005081-kxrzv16n	98	26	proteolysis	proteolysis	NN
cord-005081-kxrzv16n	98	27	with	with	IN
cord-005081-kxrzv16n	98	28	furine	furine	NN
cord-005081-kxrzv16n	98	29	proteases	protease	NNS
cord-005081-kxrzv16n	98	30	.	.	.
cord-005081-kxrzv16n	99	1	After	after	IN
cord-005081-kxrzv16n	99	2	the	the	DT
cord-005081-kxrzv16n	99	3	site	site	NN
cord-005081-kxrzv16n	99	4	was	be	VBD
cord-005081-kxrzv16n	99	5	removed	remove	VBN
cord-005081-kxrzv16n	99	6	from	from	IN
cord-005081-kxrzv16n	99	7	the	the	DT
cord-005081-kxrzv16n	99	8	cloned	clone	VBN
cord-005081-kxrzv16n	99	9	gene	gene	NN
cord-005081-kxrzv16n	99	10	its	-PRON-	PRP$
cord-005081-kxrzv16n	99	11	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	99	12	significantly	significantly	RB
cord-005081-kxrzv16n	99	13	decreased	decrease	VBD
cord-005081-kxrzv16n	99	14	,	,	,
cord-005081-kxrzv16n	99	15	being	be	VBG
cord-005081-kxrzv16n	99	16	in	in	IN
cord-005081-kxrzv16n	99	17	conformity	conformity	NN
cord-005081-kxrzv16n	99	18	with	with	IN
cord-005081-kxrzv16n	99	19	the	the	DT
cord-005081-kxrzv16n	99	20	requirements	requirement	NNS
cord-005081-kxrzv16n	99	21	for	for	IN
cord-005081-kxrzv16n	99	22	candidate	candidate	NN
cord-005081-kxrzv16n	99	23	vaccine	vaccine	NN
cord-005081-kxrzv16n	99	24	strains	strain	NNS
cord-005081-kxrzv16n	99	25	.	.	.
cord-005081-kxrzv16n	100	1	The	the	DT
cord-005081-kxrzv16n	100	2	A	A	NNP
cord-005081-kxrzv16n	100	3	/	/	SYM
cord-005081-kxrzv16n	100	4	PR/8/34	pr/8/34	NN
cord-005081-kxrzv16n	100	5	virus	virus	NN
cord-005081-kxrzv16n	100	6	is	be	VBZ
cord-005081-kxrzv16n	100	7	still	still	RB
cord-005081-kxrzv16n	100	8	used	use	VBN
cord-005081-kxrzv16n	100	9	as	as	IN
cord-005081-kxrzv16n	100	10	a	a	DT
cord-005081-kxrzv16n	100	11	successful	successful	JJ
cord-005081-kxrzv16n	100	12	donor	donor	NN
cord-005081-kxrzv16n	100	13	of	of	IN
cord-005081-kxrzv16n	100	14	high	high	JJ
cord-005081-kxrzv16n	100	15	reproductive	reproductive	JJ
cord-005081-kxrzv16n	100	16	activity	activity	NN
cord-005081-kxrzv16n	100	17	.	.	.
cord-005081-kxrzv16n	101	1	This	this	DT
cord-005081-kxrzv16n	101	2	very	very	JJ
cord-005081-kxrzv16n	101	3	strain	strain	NN
cord-005081-kxrzv16n	101	4	served	serve	VBN
cord-005081-kxrzv16n	101	5	as	as	IN
cord-005081-kxrzv16n	101	6	the	the	DT
cord-005081-kxrzv16n	101	7	donor	donor	NN
cord-005081-kxrzv16n	101	8	for	for	IN
cord-005081-kxrzv16n	101	9	constructing	construct	VBG
cord-005081-kxrzv16n	101	10	important	important	JJ
cord-005081-kxrzv16n	101	11	viruses	virus	NNS
cord-005081-kxrzv16n	101	12	for	for	IN
cord-005081-kxrzv16n	101	13	inactivated	inactivate	VBN
cord-005081-kxrzv16n	101	14	,	,	,
cord-005081-kxrzv16n	101	15	predominantly	predominantly	RB
cord-005081-kxrzv16n	101	16	whole	whole	JJ
cord-005081-kxrzv16n	101	17	virion	virion	NN
cord-005081-kxrzv16n	101	18	vaccines	vaccine	NNS
cord-005081-kxrzv16n	101	19	at	at	IN
cord-005081-kxrzv16n	101	20	the	the	DT
cord-005081-kxrzv16n	101	21	Research	Research	NNP
cord-005081-kxrzv16n	101	22	Institute	Institute	NNP
cord-005081-kxrzv16n	101	23	of	of	IN
cord-005081-kxrzv16n	101	24	Influenza	Influenza	NNP
cord-005081-kxrzv16n	101	25	(	(	-LRB-
cord-005081-kxrzv16n	101	26	St.	St.	NNP
cord-005081-kxrzv16n	101	27	Petersburg	Petersburg	NNP
cord-005081-kxrzv16n	101	28	)	)	-RRB-
cord-005081-kxrzv16n	101	29	.	.	.
cord-005081-kxrzv16n	102	1	The	the	DT
cord-005081-kxrzv16n	102	2	vaccine	vaccine	NN
cord-005081-kxrzv16n	102	3	passed	pass	VBD
cord-005081-kxrzv16n	102	4	through	through	IN
cord-005081-kxrzv16n	102	5	preliminary	preliminary	JJ
cord-005081-kxrzv16n	102	6	trials	trial	NNS
cord-005081-kxrzv16n	102	7	for	for	IN
cord-005081-kxrzv16n	102	8	effi	effi	NNP
cord-005081-kxrzv16n	102	9	cacy	cacy	NNP
cord-005081-kxrzv16n	102	10	,	,	,
cord-005081-kxrzv16n	102	11	genetic	genetic	JJ
cord-005081-kxrzv16n	102	12	stability	stability	NN
cord-005081-kxrzv16n	102	13	,	,	,
cord-005081-kxrzv16n	102	14	and	and	CC
cord-005081-kxrzv16n	102	15	antigenic	antigenic	JJ
cord-005081-kxrzv16n	102	16	homogeneity	homogeneity	NN
cord-005081-kxrzv16n	102	17	;	;	:
cord-005081-kxrzv16n	102	18	the	the	DT
cord-005081-kxrzv16n	102	19	preparation	preparation	NN
cord-005081-kxrzv16n	102	20	is	be	VBZ
cord-005081-kxrzv16n	102	21	being	be	VBG
cord-005081-kxrzv16n	102	22	prepared	prepare	VBN
cord-005081-kxrzv16n	102	23	now	now	RB
cord-005081-kxrzv16n	102	24	for	for	IN
cord-005081-kxrzv16n	102	25	clinical	clinical	JJ
cord-005081-kxrzv16n	102	26	trials	trial	NNS
cord-005081-kxrzv16n	102	27	.	.	.
cord-005081-kxrzv16n	103	1	Development	development	NN
cord-005081-kxrzv16n	103	2	of	of	IN
cord-005081-kxrzv16n	103	3	inactivated	inactivate	VBN
cord-005081-kxrzv16n	103	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	103	5	or	or	CC
cord-005081-kxrzv16n	103	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	103	7	with	with	IN
cord-005081-kxrzv16n	103	8	modified	modified	JJ
cord-005081-kxrzv16n	103	9	NS1	NS1	NNS
cord-005081-kxrzv16n	103	10	and	and	CC
cord-005081-kxrzv16n	103	11	PB2	PB2	NNP
cord-005081-kxrzv16n	103	12	genes	gene	NNS
cord-005081-kxrzv16n	103	13	,	,	,
cord-005081-kxrzv16n	103	14	replication	replication	NN
cord-005081-kxrzv16n	103	15	defi	defi	NNP
cord-005081-kxrzv16n	103	16	cient	cient	NN
cord-005081-kxrzv16n	103	17	in	in	IN
cord-005081-kxrzv16n	103	18	the	the	DT
cord-005081-kxrzv16n	103	19	human	human	JJ
cord-005081-kxrzv16n	103	20	body	body	NN
cord-005081-kxrzv16n	103	21	,	,	,
cord-005081-kxrzv16n	103	22	is	be	VBZ
cord-005081-kxrzv16n	103	23	recommended	recommend	VBN
cord-005081-kxrzv16n	103	24	for	for	IN
cord-005081-kxrzv16n	103	25	obvious	obvious	JJ
cord-005081-kxrzv16n	103	26	reasons	reason	NNS
cord-005081-kxrzv16n	103	27	.	.	.
cord-005081-kxrzv16n	104	1	Such	such	JJ
cord-005081-kxrzv16n	104	2	vaccines	vaccine	NNS
cord-005081-kxrzv16n	104	3	are	be	VBP
cord-005081-kxrzv16n	104	4	obtained	obtain	VBN
cord-005081-kxrzv16n	104	5	by	by	IN
cord-005081-kxrzv16n	104	6	reverse	reverse	JJ
cord-005081-kxrzv16n	104	7	genet	genet	NN
cord-005081-kxrzv16n	104	8	ics	ics	NNP
cord-005081-kxrzv16n	104	9	techniques	technique	NNS
cord-005081-kxrzv16n	104	10	mastered	master	VBN
cord-005081-kxrzv16n	104	11	at	at	IN
cord-005081-kxrzv16n	104	12	the	the	DT
cord-005081-kxrzv16n	104	13	international	international	JJ
cord-005081-kxrzv16n	104	14	laboratory	laboratory	NN
cord-005081-kxrzv16n	104	15	of	of	IN
cord-005081-kxrzv16n	104	16	the	the	DT
cord-005081-kxrzv16n	104	17	Research	Research	NNP
cord-005081-kxrzv16n	104	18	Institute	Institute	NNP
cord-005081-kxrzv16n	104	19	of	of	IN
cord-005081-kxrzv16n	104	20	Influenza	Influenza	NNP
cord-005081-kxrzv16n	104	21	,	,	,
cord-005081-kxrzv16n	104	22	RAMS	RAMS	NNP
cord-005081-kxrzv16n	104	23	(	(	-LRB-
cord-005081-kxrzv16n	104	24	Fig	Fig	NNP
cord-005081-kxrzv16n	104	25	.	.	NNP
cord-005081-kxrzv16n	104	26	2	2	CD
cord-005081-kxrzv16n	104	27	)	)	-RRB-
cord-005081-kxrzv16n	104	28	.	.	.
cord-005081-kxrzv16n	105	1	A	a	DT
cord-005081-kxrzv16n	105	2	further	further	JJ
cord-005081-kxrzv16n	105	3	attenuation	attenuation	NN
cord-005081-kxrzv16n	105	4	of	of	IN
cord-005081-kxrzv16n	105	5	the	the	DT
cord-005081-kxrzv16n	105	6	virus	virus	NN
cord-005081-kxrzv16n	105	7	through	through	IN
cord-005081-kxrzv16n	105	8	genetic	genetic	JJ
cord-005081-kxrzv16n	105	9	modifications	modification	NNS
cord-005081-kxrzv16n	105	10	is	be	VBZ
cord-005081-kxrzv16n	105	11	possible	possible	JJ
cord-005081-kxrzv16n	105	12	by	by	IN
cord-005081-kxrzv16n	105	13	obtaining	obtain	VBG
cord-005081-kxrzv16n	105	14	strains	strain	NNS
cord-005081-kxrzv16n	105	15	with	with	IN
cord-005081-kxrzv16n	105	16	lengthy	lengthy	JJ
cord-005081-kxrzv16n	105	17	deletions	deletion	NNS
cord-005081-kxrzv16n	105	18	in	in	IN
cord-005081-kxrzv16n	105	19	the	the	DT
cord-005081-kxrzv16n	105	20	NS1	ns1	NN
cord-005081-kxrzv16n	105	21	gene	gene	NN
cord-005081-kxrzv16n	105	22	encoding	encode	VBG
cord-005081-kxrzv16n	105	23	the	the	DT
cord-005081-kxrzv16n	105	24	antag	antag	NNP
cord-005081-kxrzv16n	105	25	onist	onist	NNP
cord-005081-kxrzv16n	105	26	of	of	IN
cord-005081-kxrzv16n	105	27	the	the	DT
cord-005081-kxrzv16n	105	28	first	first	JJ
cord-005081-kxrzv16n	105	29	type	type	NN
cord-005081-kxrzv16n	105	30	interferons	interferon	NNS
cord-005081-kxrzv16n	105	31	and	and	CC
cord-005081-kxrzv16n	105	32	the	the	DT
cord-005081-kxrzv16n	105	33	signaling	signal	VBG
cord-005081-kxrzv16n	105	34	domain	domain	NN
cord-005081-kxrzv16n	105	35	PDZ	PDZ	NNP
cord-005081-kxrzv16n	105	36	localized	localize	VBN
cord-005081-kxrzv16n	105	37	at	at	IN
cord-005081-kxrzv16n	105	38	C	c	NN
cord-005081-kxrzv16n	105	39	end	end	NN
cord-005081-kxrzv16n	105	40	of	of	IN
cord-005081-kxrzv16n	105	41	this	this	DT
cord-005081-kxrzv16n	105	42	viral	viral	JJ
cord-005081-kxrzv16n	105	43	protein	protein	NN
cord-005081-kxrzv16n	105	44	[	[	-LRB-
cord-005081-kxrzv16n	105	45	7	7	CD
cord-005081-kxrzv16n	105	46	,	,	,
cord-005081-kxrzv16n	105	47	13	13	CD
cord-005081-kxrzv16n	105	48	]	]	-RRB-
cord-005081-kxrzv16n	105	49	.	.	.
cord-005081-kxrzv16n	106	1	The	the	DT
cord-005081-kxrzv16n	106	2	level	level	NN
cord-005081-kxrzv16n	106	3	of	of	IN
cord-005081-kxrzv16n	106	4	this	this	DT
cord-005081-kxrzv16n	106	5	technology	technology	NN
cord-005081-kxrzv16n	106	6	is	be	VBZ
cord-005081-kxrzv16n	106	7	so	so	RB
cord-005081-kxrzv16n	106	8	sophisticated	sophisticated	JJ
cord-005081-kxrzv16n	106	9	that	that	IN
cord-005081-kxrzv16n	106	10	using	use	VBG
cord-005081-kxrzv16n	106	11	the	the	DT
cord-005081-kxrzv16n	106	12	8	8	CD
cord-005081-kxrzv16n	106	13	plasmid	plasmid	NN
cord-005081-kxrzv16n	106	14	technique	technique	NN
cord-005081-kxrzv16n	106	15	complete	complete	JJ
cord-005081-kxrzv16n	106	16	copies	copy	NNS
cord-005081-kxrzv16n	106	17	of	of	IN
cord-005081-kxrzv16n	106	18	highly	highly	RB
cord-005081-kxrzv16n	106	19	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	106	20	viral	viral	JJ
cord-005081-kxrzv16n	106	21	isolates	isolate	NNS
cord-005081-kxrzv16n	106	22	can	can	MD
cord-005081-kxrzv16n	106	23	be	be	VB
cord-005081-kxrzv16n	106	24	constructed	construct	VBN
cord-005081-kxrzv16n	106	25	.	.	.
cord-005081-kxrzv16n	107	1	In	in	IN
cord-005081-kxrzv16n	107	2	particular	particular	JJ
cord-005081-kxrzv16n	107	3	,	,	,
cord-005081-kxrzv16n	107	4	within	within	IN
cord-005081-kxrzv16n	107	5	the	the	DT
cord-005081-kxrzv16n	107	6	European	european	JJ
cord-005081-kxrzv16n	107	7	project	project	NN
cord-005081-kxrzv16n	107	8	FluVac	FluVac	NNP
cord-005081-kxrzv16n	107	9	,	,	,
cord-005081-kxrzv16n	107	10	we	-PRON-	PRP
cord-005081-kxrzv16n	107	11	obtained	obtain	VBD
cord-005081-kxrzv16n	107	12	a	a	DT
cord-005081-kxrzv16n	107	13	complete	complete	JJ
cord-005081-kxrzv16n	107	14	copy	copy	NN
cord-005081-kxrzv16n	107	15	of	of	IN
cord-005081-kxrzv16n	107	16	the	the	DT
cord-005081-kxrzv16n	107	17	Kurgan	Kurgan	NNP
cord-005081-kxrzv16n	107	18	H5N1	H5N1	NNP
cord-005081-kxrzv16n	107	19	2005	2005	CD
cord-005081-kxrzv16n	107	20	virus	virus	NN
cord-005081-kxrzv16n	107	21	isolate	isolate	VBP
cord-005081-kxrzv16n	107	22	.	.	.
cord-005081-kxrzv16n	108	1	The	the	DT
cord-005081-kxrzv16n	108	2	representative	representative	JJ
cord-005081-kxrzv16n	108	3	scheme	scheme	NN
cord-005081-kxrzv16n	108	4	(	(	-LRB-
cord-005081-kxrzv16n	108	5	see	see	VB
cord-005081-kxrzv16n	108	6	Fig	Fig	NNP
cord-005081-kxrzv16n	108	7	.	.	NNP
cord-005081-kxrzv16n	108	8	2	2	CD
cord-005081-kxrzv16n	108	9	)	)	-RRB-
cord-005081-kxrzv16n	108	10	for	for	IN
cord-005081-kxrzv16n	108	11	the	the	DT
cord-005081-kxrzv16n	108	12	vac	vac	NNP
cord-005081-kxrzv16n	108	13	cine	cine	NNP
cord-005081-kxrzv16n	108	14	NI	NI	NNP
cord-005081-kxrzv16n	108	15	BRG	BRG	NNP
cord-005081-kxrzv16n	108	16	14	14	CD
cord-005081-kxrzv16n	108	17	virus	virus	NN
cord-005081-kxrzv16n	108	18	assembly	assembly	NN
cord-005081-kxrzv16n	108	19	shows	show	VBZ
cord-005081-kxrzv16n	108	20	the	the	DT
cord-005081-kxrzv16n	108	21	removal	removal	NN
cord-005081-kxrzv16n	108	22	of	of	IN
cord-005081-kxrzv16n	108	23	the	the	DT
cord-005081-kxrzv16n	108	24	proteolysis	proteolysis	NN
cord-005081-kxrzv16n	108	25	site	site	NN
cord-005081-kxrzv16n	108	26	RERRRKKR	RERRRKKR	NNP
cord-005081-kxrzv16n	108	27	and	and	CC
cord-005081-kxrzv16n	108	28	insertion	insertion	NN
cord-005081-kxrzv16n	108	29	of	of	IN
cord-005081-kxrzv16n	108	30	a	a	DT
cord-005081-kxrzv16n	108	31	new	new	JJ
cord-005081-kxrzv16n	108	32	"	"	``
cord-005081-kxrzv16n	108	33	attenuated	attenuated	JJ
cord-005081-kxrzv16n	108	34	"	"	''
cord-005081-kxrzv16n	108	35	site	site	NN
cord-005081-kxrzv16n	108	36	RETR	RETR	NNP
cord-005081-kxrzv16n	108	37	.	.	.
cord-005081-kxrzv16n	109	1	The	the	DT
cord-005081-kxrzv16n	109	2	NA	NA	NNP
cord-005081-kxrzv16n	109	3	gene	gene	NN
cord-005081-kxrzv16n	109	4	in	in	IN
cord-005081-kxrzv16n	109	5	this	this	DT
cord-005081-kxrzv16n	109	6	construction	construction	NN
cord-005081-kxrzv16n	109	7	remained	remain	VBD
cord-005081-kxrzv16n	109	8	intact	intact	JJ
cord-005081-kxrzv16n	109	9	.	.	.
cord-005081-kxrzv16n	110	1	The	the	DT
cord-005081-kxrzv16n	110	2	vaccine	vaccine	NN
cord-005081-kxrzv16n	110	3	strain	strain	NN
cord-005081-kxrzv16n	110	4	on	on	IN
cord-005081-kxrzv16n	110	5	this	this	DT
cord-005081-kxrzv16n	110	6	base	base	NN
cord-005081-kxrzv16n	110	7	has	have	VBZ
cord-005081-kxrzv16n	110	8	specially	specially	RB
cord-005081-kxrzv16n	110	9	been	be	VBN
cord-005081-kxrzv16n	110	10	prepared	prepare	VBN
cord-005081-kxrzv16n	110	11	for	for	IN
cord-005081-kxrzv16n	110	12	the	the	DT
cord-005081-kxrzv16n	110	13	use	use	NN
cord-005081-kxrzv16n	110	14	in	in	IN
cord-005081-kxrzv16n	110	15	the	the	DT
cord-005081-kxrzv16n	110	16	territory	territory	NN
cord-005081-kxrzv16n	110	17	of	of	IN
cord-005081-kxrzv16n	110	18	the	the	DT
cord-005081-kxrzv16n	110	19	Russian	Russian	NNP
cord-005081-kxrzv16n	110	20	Federation	Federation	NNP
cord-005081-kxrzv16n	110	21	.	.	.
cord-005081-kxrzv16n	111	1	Manipulations	manipulation	NNS
cord-005081-kxrzv16n	111	2	with	with	IN
cord-005081-kxrzv16n	111	3	the	the	DT
cord-005081-kxrzv16n	111	4	NS1	ns1	NN
cord-005081-kxrzv16n	111	5	gene	gene	NN
cord-005081-kxrzv16n	111	6	were	be	VBD
cord-005081-kxrzv16n	111	7	put	put	VBN
cord-005081-kxrzv16n	111	8	into	into	IN
cord-005081-kxrzv16n	111	9	the	the	DT
cord-005081-kxrzv16n	111	10	basis	basis	NN
cord-005081-kxrzv16n	111	11	of	of	IN
cord-005081-kxrzv16n	111	12	a	a	DT
cord-005081-kxrzv16n	111	13	new	new	JJ
cord-005081-kxrzv16n	111	14	technology	technology	NN
cord-005081-kxrzv16n	111	15	for	for	IN
cord-005081-kxrzv16n	111	16	obtaining	obtain	VBG
cord-005081-kxrzv16n	111	17	influenza	influenza	NN
cord-005081-kxrzv16n	111	18	viruses	virus	NNS
cord-005081-kxrzv16n	111	19	with	with	IN
cord-005081-kxrzv16n	111	20	limited	limited	JJ
cord-005081-kxrzv16n	111	21	replication	replication	NN
cord-005081-kxrzv16n	111	22	potentialreplicatively	potentialreplicatively	RB
cord-005081-kxrzv16n	111	23	deficient	deficient	JJ
cord-005081-kxrzv16n	111	24	strains	strain	NNS
cord-005081-kxrzv16n	111	25	[	[	-LRB-
cord-005081-kxrzv16n	111	26	20	20	CD
cord-005081-kxrzv16n	111	27	,	,	,
cord-005081-kxrzv16n	111	28	21	21	CD
cord-005081-kxrzv16n	111	29	]	]	-RRB-
cord-005081-kxrzv16n	111	30	-aimed	-aime	VBN
cord-005081-kxrzv16n	111	31	to	to	TO
cord-005081-kxrzv16n	111	32	replace	replace	VB
cord-005081-kxrzv16n	111	33	LAIV	LAIV	NNP
cord-005081-kxrzv16n	111	34	as	as	IN
cord-005081-kxrzv16n	111	35	more	more	RBR
cord-005081-kxrzv16n	111	36	safe	safe	JJ
cord-005081-kxrzv16n	111	37	and	and	CC
cord-005081-kxrzv16n	111	38	efficacious	efficacious	JJ
cord-005081-kxrzv16n	111	39	.	.	.
cord-005081-kxrzv16n	112	1	The	the	DT
cord-005081-kxrzv16n	112	2	safety	safety	NN
cord-005081-kxrzv16n	112	3	of	of	IN
cord-005081-kxrzv16n	112	4	these	these	DT
cord-005081-kxrzv16n	112	5	vaccines	vaccine	NNS
cord-005081-kxrzv16n	112	6	is	be	VBZ
cord-005081-kxrzv16n	112	7	assessed	assess	VBN
cord-005081-kxrzv16n	112	8	primarily	primarily	RB
cord-005081-kxrzv16n	112	9	by	by	IN
cord-005081-kxrzv16n	112	10	their	-PRON-	PRP$
cord-005081-kxrzv16n	112	11	high	high	JJ
cord-005081-kxrzv16n	112	12	sensitivity	sensitivity	NN
cord-005081-kxrzv16n	112	13	to	to	IN
cord-005081-kxrzv16n	112	14	the	the	DT
cord-005081-kxrzv16n	112	15	endogenous	endogenous	JJ
cord-005081-kxrzv16n	112	16	interferon	interferon	NN
cord-005081-kxrzv16n	112	17	.	.	.
cord-005081-kxrzv16n	113	1	An	an	DT
cord-005081-kxrzv16n	113	2	influenza	influenza	NN
cord-005081-kxrzv16n	113	3	Table	table	NN
cord-005081-kxrzv16n	113	4	2	2	CD
cord-005081-kxrzv16n	113	5	;	;	.
cord-005081-kxrzv16n	114	1	N1-neuraminidase	N1-neuraminidase	NNP
cord-005081-kxrzv16n	114	2	1	1	CD
cord-005081-kxrzv16n	114	3	;	;	:
cord-005081-kxrzv16n	114	4	see	see	VB
cord-005081-kxrzv16n	114	5	explanations	explanation	NNS
cord-005081-kxrzv16n	114	6	in	in	IN
cord-005081-kxrzv16n	114	7	the	the	DT
cord-005081-kxrzv16n	114	8	text	text	NN
cord-005081-kxrzv16n	114	9	.	.	.
cord-005081-kxrzv16n	115	1	virus	virus	NN
cord-005081-kxrzv16n	115	2	is	be	VBZ
cord-005081-kxrzv16n	115	3	a	a	DT
cord-005081-kxrzv16n	115	4	strong	strong	JJ
cord-005081-kxrzv16n	115	5	inductor	inductor	NN
cord-005081-kxrzv16n	115	6	of	of	IN
cord-005081-kxrzv16n	115	7	interferon	interferon	NN
cord-005081-kxrzv16n	115	8	and	and	CC
cord-005081-kxrzv16n	115	9	,	,	,
cord-005081-kxrzv16n	115	10	therefore	therefore	RB
cord-005081-kxrzv16n	115	11	,	,	,
cord-005081-kxrzv16n	115	12	viruses	virus	NNS
cord-005081-kxrzv16n	115	13	deprived	deprive	VBN
cord-005081-kxrzv16n	115	14	of	of	IN
cord-005081-kxrzv16n	115	15	the	the	DT
cord-005081-kxrzv16n	115	16	interferon	interferon	NN
cord-005081-kxrzv16n	115	17	antagonist	antagonist	NN
cord-005081-kxrzv16n	115	18	-	-	HYPH
cord-005081-kxrzv16n	115	19	full	full	JJ
cord-005081-kxrzv16n	115	20	value	value	NN
cord-005081-kxrzv16n	115	21	protein	protein	NN
cord-005081-kxrzv16n	115	22	NS1-are	NS1-are	NNP
cord-005081-kxrzv16n	115	23	quickly	quickly	RB
cord-005081-kxrzv16n	115	24	eliminated	eliminate	VBD
cord-005081-kxrzv16n	115	25	from	from	IN
cord-005081-kxrzv16n	115	26	the	the	DT
cord-005081-kxrzv16n	115	27	body	body	NN
cord-005081-kxrzv16n	115	28	under	under	IN
cord-005081-kxrzv16n	115	29	the	the	DT
cord-005081-kxrzv16n	115	30	action	action	NN
cord-005081-kxrzv16n	115	31	of	of	IN
cord-005081-kxrzv16n	115	32	interferon	interferon	NN
cord-005081-kxrzv16n	115	33	I	I	NNP
cord-005081-kxrzv16n	115	34	and	and	CC
cord-005081-kxrzv16n	115	35	II	ii	CD
cord-005081-kxrzv16n	115	36	types	type	NNS
cord-005081-kxrzv16n	115	37	after	after	IN
cord-005081-kxrzv16n	115	38	a	a	DT
cord-005081-kxrzv16n	115	39	short	short	JJ
cord-005081-kxrzv16n	115	40	cycle	cycle	NN
cord-005081-kxrzv16n	115	41	of	of	IN
cord-005081-kxrzv16n	115	42	reproduction	reproduction	NN
cord-005081-kxrzv16n	115	43	.	.	.
cord-005081-kxrzv16n	116	1	This	this	DT
cord-005081-kxrzv16n	116	2	fact	fact	NN
cord-005081-kxrzv16n	116	3	enables	enable	VBZ
cord-005081-kxrzv16n	116	4	us	-PRON-	PRP
cord-005081-kxrzv16n	116	5	to	to	TO
cord-005081-kxrzv16n	116	6	use	use	VB
cord-005081-kxrzv16n	116	7	the	the	DT
cord-005081-kxrzv16n	116	8	influenza	influenza	NN
cord-005081-kxrzv16n	116	9	virus	virus	NN
cord-005081-kxrzv16n	116	10	as	as	IN
cord-005081-kxrzv16n	116	11	a	a	DT
cord-005081-kxrzv16n	116	12	safe	safe	JJ
cord-005081-kxrzv16n	116	13	vector	vector	NN
cord-005081-kxrzv16n	116	14	.	.	.
cord-005081-kxrzv16n	117	1	In	in	IN
cord-005081-kxrzv16n	117	2	our	-PRON-	PRP$
cord-005081-kxrzv16n	117	3	work	work	NN
cord-005081-kxrzv16n	117	4	the	the	DT
cord-005081-kxrzv16n	117	5	influenza	influenza	NN
cord-005081-kxrzv16n	117	6	virus	virus	NN
cord-005081-kxrzv16n	117	7	was	be	VBD
cord-005081-kxrzv16n	117	8	used	use	VBN
cord-005081-kxrzv16n	117	9	as	as	IN
cord-005081-kxrzv16n	117	10	a	a	DT
cord-005081-kxrzv16n	117	11	vector	vector	NN
cord-005081-kxrzv16n	117	12	for	for	IN
cord-005081-kxrzv16n	117	13	obtaining	obtain	VBG
cord-005081-kxrzv16n	117	14	the	the	DT
cord-005081-kxrzv16n	117	15	strain	strain	NN
cord-005081-kxrzv16n	117	16	expressing	express	VBG
cord-005081-kxrzv16n	117	17	the	the	DT
cord-005081-kxrzv16n	117	18	ESAT	ESAT	NNP
cord-005081-kxrzv16n	117	19	6	6	CD
cord-005081-kxrzv16n	117	20	protein	protein	NN
cord-005081-kxrzv16n	117	21	of	of	IN
cord-005081-kxrzv16n	117	22	the	the	DT
cord-005081-kxrzv16n	117	23	TB	TB	NNP
cord-005081-kxrzv16n	117	24	caus	caus	NNP
cord-005081-kxrzv16n	117	25	ing	e	VBG
cord-005081-kxrzv16n	117	26	bacteria	bacteria	NNS
cord-005081-kxrzv16n	117	27	[	[	-LRB-
cord-005081-kxrzv16n	117	28	22	22	CD
cord-005081-kxrzv16n	117	29	]	]	-RRB-
cord-005081-kxrzv16n	117	30	[	[	-LRB-
cord-005081-kxrzv16n	117	31	23	23	CD
cord-005081-kxrzv16n	117	32	]	]	-RRB-
cord-005081-kxrzv16n	117	33	[	[	-LRB-
cord-005081-kxrzv16n	117	34	24	24	CD
cord-005081-kxrzv16n	117	35	]	]	-RRB-
cord-005081-kxrzv16n	117	36	.	.	.
cord-005081-kxrzv16n	118	1	The	the	DT
cord-005081-kxrzv16n	118	2	intranasally	intranasally	RB
cord-005081-kxrzv16n	118	3	administered	administer	VBN
cord-005081-kxrzv16n	118	4	modified	modified	JJ
cord-005081-kxrzv16n	118	5	virus	virus	NN
cord-005081-kxrzv16n	118	6	manifested	manifest	VBN
cord-005081-kxrzv16n	118	7	in	in	IN
cord-005081-kxrzv16n	118	8	animals	animal	NNS
cord-005081-kxrzv16n	118	9	the	the	DT
cord-005081-kxrzv16n	118	10	properties	property	NNS
cord-005081-kxrzv16n	118	11	of	of	IN
cord-005081-kxrzv16n	118	12	an	an	DT
cord-005081-kxrzv16n	118	13	antitubercular	antitubercular	JJ
cord-005081-kxrzv16n	118	14	vaccine	vaccine	NN
cord-005081-kxrzv16n	118	15	[	[	-LRB-
cord-005081-kxrzv16n	118	16	23	23	CD
cord-005081-kxrzv16n	118	17	]	]	-RRB-
cord-005081-kxrzv16n	118	18	.	.	.
cord-005081-kxrzv16n	119	1	The	the	DT
cord-005081-kxrzv16n	119	2	arsenal	arsenal	NN
cord-005081-kxrzv16n	119	3	of	of	IN
cord-005081-kxrzv16n	119	4	approaches	approach	NNS
cord-005081-kxrzv16n	119	5	to	to	IN
cord-005081-kxrzv16n	119	6	the	the	DT
cord-005081-kxrzv16n	119	7	technological	technological	JJ
cord-005081-kxrzv16n	119	8	development	development	NN
cord-005081-kxrzv16n	119	9	and	and	CC
cord-005081-kxrzv16n	119	10	solutions	solution	NNS
cord-005081-kxrzv16n	119	11	in	in	IN
cord-005081-kxrzv16n	119	12	constructing	construct	VBG
cord-005081-kxrzv16n	119	13	and	and	CC
cord-005081-kxrzv16n	119	14	manu	manu	NNP
cord-005081-kxrzv16n	119	15	facturing	facturing	NNP
cord-005081-kxrzv16n	119	16	influenza	influenza	NN
cord-005081-kxrzv16n	119	17	vaccines	vaccine	NNS
cord-005081-kxrzv16n	119	18	has	have	VBZ
cord-005081-kxrzv16n	119	19	become	become	VBN
cord-005081-kxrzv16n	119	20	considerably	considerably	RB
cord-005081-kxrzv16n	119	21	more	more	RBR
cord-005081-kxrzv16n	119	22	substantial	substantial	JJ
cord-005081-kxrzv16n	119	23	over	over	IN
cord-005081-kxrzv16n	119	24	recent	recent	JJ
cord-005081-kxrzv16n	119	25	years	year	NNS
cord-005081-kxrzv16n	119	26	.	.	.
cord-005081-kxrzv16n	120	1	The	the	DT
cord-005081-kxrzv16n	120	2	annual	annual	JJ
cord-005081-kxrzv16n	120	3	prepa	prepa	JJ
cord-005081-kxrzv16n	120	4	ration	ration	NN
cord-005081-kxrzv16n	120	5	of	of	IN
cord-005081-kxrzv16n	120	6	conventional	conventional	JJ
cord-005081-kxrzv16n	120	7	vaccines	vaccine	NNS
cord-005081-kxrzv16n	120	8	(	(	-LRB-
cord-005081-kxrzv16n	120	9	live	live	VBP
cord-005081-kxrzv16n	120	10	attenuated	attenuated	JJ
cord-005081-kxrzv16n	120	11	,	,	,
cord-005081-kxrzv16n	120	12	whole	whole	JJ
cord-005081-kxrzv16n	120	13	virion	virion	NN
cord-005081-kxrzv16n	120	14	,	,	,
cord-005081-kxrzv16n	120	15	and	and	CC
cord-005081-kxrzv16n	120	16	split	split	VB
cord-005081-kxrzv16n	120	17	and	and	CC
cord-005081-kxrzv16n	120	18	subunit	subunit	NN
cord-005081-kxrzv16n	120	19	vaccines	vaccine	NNS
cord-005081-kxrzv16n	120	20	)	)	-RRB-
cord-005081-kxrzv16n	120	21	includes	include	VBZ
cord-005081-kxrzv16n	120	22	,	,	,
cord-005081-kxrzv16n	120	23	in	in	IN
cord-005081-kxrzv16n	120	24	the	the	DT
cord-005081-kxrzv16n	120	25	first	first	JJ
cord-005081-kxrzv16n	120	26	place	place	NN
cord-005081-kxrzv16n	120	27	,	,	,
cord-005081-kxrzv16n	120	28	the	the	DT
cord-005081-kxrzv16n	120	29	phase	phase	NN
cord-005081-kxrzv16n	120	30	of	of	IN
cord-005081-kxrzv16n	120	31	obtaining	obtain	VBG
cord-005081-kxrzv16n	120	32	vac	vac	NN
cord-005081-kxrzv16n	120	33	cine	cine	JJ
cord-005081-kxrzv16n	120	34	strains	strain	NNS
cord-005081-kxrzv16n	120	35	,	,	,
cord-005081-kxrzv16n	120	36	which	which	WDT
cord-005081-kxrzv16n	120	37	usually	usually	RB
cord-005081-kxrzv16n	120	38	takes	take	VBZ
cord-005081-kxrzv16n	120	39	up	up	RP
cord-005081-kxrzv16n	120	40	to	to	TO
cord-005081-kxrzv16n	120	41	6	6	CD
cord-005081-kxrzv16n	120	42	months	month	NNS
cord-005081-kxrzv16n	120	43	.	.	.
cord-005081-kxrzv16n	121	1	Many	many	JJ
cord-005081-kxrzv16n	121	2	technological	technological	JJ
cord-005081-kxrzv16n	121	3	techniques	technique	NNS
cord-005081-kxrzv16n	121	4	and	and	CC
cord-005081-kxrzv16n	121	5	innovations	innovation	NNS
cord-005081-kxrzv16n	121	6	are	be	VBP
cord-005081-kxrzv16n	121	7	oriented	orient	VBN
cord-005081-kxrzv16n	121	8	to	to	IN
cord-005081-kxrzv16n	121	9	the	the	DT
cord-005081-kxrzv16n	121	10	prompt	prompt	JJ
cord-005081-kxrzv16n	121	11	preparation	preparation	NN
cord-005081-kxrzv16n	121	12	of	of	IN
cord-005081-kxrzv16n	121	13	antigen	antigen	NN
cord-005081-kxrzv16n	121	14	producers	producer	NNS
cord-005081-kxrzv16n	121	15	and	and	CC
cord-005081-kxrzv16n	121	16	the	the	DT
cord-005081-kxrzv16n	121	17	possibility	possibility	NN
cord-005081-kxrzv16n	121	18	to	to	TO
cord-005081-kxrzv16n	121	19	modify	modify	VB
cord-005081-kxrzv16n	121	20	them	-PRON-	PRP
cord-005081-kxrzv16n	121	21	in	in	IN
cord-005081-kxrzv16n	121	22	correspondence	correspondence	NN
cord-005081-kxrzv16n	121	23	with	with	IN
cord-005081-kxrzv16n	121	24	the	the	DT
cord-005081-kxrzv16n	121	25	data	datum	NNS
cord-005081-kxrzv16n	121	26	on	on	IN
cord-005081-kxrzv16n	121	27	antigenic	antigenic	JJ
cord-005081-kxrzv16n	121	28	drifts	drift	NNS
cord-005081-kxrzv16n	121	29	of	of	IN
cord-005081-kxrzv16n	121	30	important	important	JJ
cord-005081-kxrzv16n	121	31	seasonal	seasonal	JJ
cord-005081-kxrzv16n	121	32	or	or	CC
cord-005081-kxrzv16n	121	33	pandemic	pandemic	NN
cord-005081-kxrzv16n	121	34	viruses	virus	NNS
cord-005081-kxrzv16n	121	35	.	.	.
cord-005081-kxrzv16n	122	1	Thus	thus	RB
cord-005081-kxrzv16n	122	2	,	,	,
cord-005081-kxrzv16n	122	3	the	the	DT
cord-005081-kxrzv16n	122	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	122	5	now	now	RB
cord-005081-kxrzv16n	122	6	in	in	IN
cord-005081-kxrzv16n	122	7	use	use	NN
cord-005081-kxrzv16n	122	8	can	can	MD
cord-005081-kxrzv16n	122	9	be	be	VB
cord-005081-kxrzv16n	122	10	supplemented	supplement	VBN
cord-005081-kxrzv16n	122	11	by	by	IN
cord-005081-kxrzv16n	122	12	the	the	DT
cord-005081-kxrzv16n	122	13	following	following	JJ
cord-005081-kxrzv16n	122	14	list	list	NN
cord-005081-kxrzv16n	122	15	:	:	:
cord-005081-kxrzv16n	122	16	DNA	dna	NN
cord-005081-kxrzv16n	122	17	vaccines	vaccine	NNS
cord-005081-kxrzv16n	122	18	,	,	,
cord-005081-kxrzv16n	122	19	recombinant	recombinant	JJ
cord-005081-kxrzv16n	122	20	subunit	subunit	NN
cord-005081-kxrzv16n	122	21	vaccines	vaccine	NNS
cord-005081-kxrzv16n	122	22	,	,	,
cord-005081-kxrzv16n	122	23	vector	vector	NN
cord-005081-kxrzv16n	122	24	based	base	VBN
cord-005081-kxrzv16n	122	25	vaccines	vaccine	NNS
cord-005081-kxrzv16n	122	26	(	(	-LRB-
cord-005081-kxrzv16n	122	27	their	-PRON-	PRP$
cord-005081-kxrzv16n	122	28	obtaining	obtain	VBG
cord-005081-kxrzv16n	122	29	is	be	VBZ
cord-005081-kxrzv16n	122	30	connected	connect	VBN
cord-005081-kxrzv16n	122	31	with	with	IN
cord-005081-kxrzv16n	122	32	the	the	DT
cord-005081-kxrzv16n	122	33	use	use	NN
cord-005081-kxrzv16n	122	34	of	of	IN
cord-005081-kxrzv16n	122	35	one	one	CD
cord-005081-kxrzv16n	122	36	of	of	IN
cord-005081-kxrzv16n	122	37	the	the	DT
cord-005081-kxrzv16n	122	38	most	most	RBS
cord-005081-kxrzv16n	122	39	attractive	attractive	JJ
cord-005081-kxrzv16n	122	40	technologies	technology	NNS
cord-005081-kxrzv16n	122	41	for	for	IN
cord-005081-kxrzv16n	122	42	virus	virus	NN
cord-005081-kxrzv16n	122	43	like	like	IN
cord-005081-kxrzv16n	122	44	particles	particle	NNS
cord-005081-kxrzv16n	122	45	)	)	-RRB-
cord-005081-kxrzv16n	122	46	,	,	,
cord-005081-kxrzv16n	122	47	and	and	CC
cord-005081-kxrzv16n	122	48	a	a	DT
cord-005081-kxrzv16n	122	49	universal	universal	JJ
cord-005081-kxrzv16n	122	50	vaccine	vaccine	NN
cord-005081-kxrzv16n	122	51	based	base	VBN
cord-005081-kxrzv16n	122	52	on	on	IN
cord-005081-kxrzv16n	122	53	highly	highly	RB
cord-005081-kxrzv16n	122	54	conservative	conservative	JJ
cord-005081-kxrzv16n	122	55	antigens	antigen	NNS
cord-005081-kxrzv16n	122	56	(	(	-LRB-
cord-005081-kxrzv16n	122	57	M2	M2	NNP
cord-005081-kxrzv16n	122	58	,	,	,
cord-005081-kxrzv16n	122	59	M1	M1	NNP
cord-005081-kxrzv16n	122	60	,	,	,
cord-005081-kxrzv16n	122	61	and	and	CC
cord-005081-kxrzv16n	122	62	NP	NP	NNP
cord-005081-kxrzv16n	122	63	proteins	protein	NNS
cord-005081-kxrzv16n	122	64	)	)	-RRB-
cord-005081-kxrzv16n	122	65	.	.	.
cord-005081-kxrzv16n	123	1	In	in	IN
cord-005081-kxrzv16n	123	2	fact	fact	NN
cord-005081-kxrzv16n	123	3	,	,	,
cord-005081-kxrzv16n	123	4	the	the	DT
cord-005081-kxrzv16n	123	5	term	term	NN
cord-005081-kxrzv16n	123	6	recombinant	recombinant	JJ
cord-005081-kxrzv16n	123	7	vaccines	vaccine	NNS
cord-005081-kxrzv16n	123	8	can	can	MD
cord-005081-kxrzv16n	123	9	define	define	VB
cord-005081-kxrzv16n	123	10	any	any	DT
cord-005081-kxrzv16n	123	11	type	type	NN
cord-005081-kxrzv16n	123	12	of	of	IN
cord-005081-kxrzv16n	123	13	vaccine	vaccine	NN
cord-005081-kxrzv16n	123	14	preparations	preparation	NNS
cord-005081-kxrzv16n	123	15	obtained	obtain	VBN
cord-005081-kxrzv16n	123	16	through	through	IN
cord-005081-kxrzv16n	123	17	genetic	genetic	JJ
cord-005081-kxrzv16n	123	18	engineering	engineering	NN
cord-005081-kxrzv16n	123	19	.	.	.
cord-005081-kxrzv16n	124	1	At	at	IN
cord-005081-kxrzv16n	124	2	the	the	DT
cord-005081-kxrzv16n	124	3	same	same	JJ
cord-005081-kxrzv16n	124	4	time	time	NN
cord-005081-kxrzv16n	124	5	,	,	,
cord-005081-kxrzv16n	124	6	considering	consider	VBG
cord-005081-kxrzv16n	124	7	the	the	DT
cord-005081-kxrzv16n	124	8	advance	advance	NN
cord-005081-kxrzv16n	124	9	of	of	IN
cord-005081-kxrzv16n	124	10	these	these	DT
cord-005081-kxrzv16n	124	11	approaches	approach	NNS
cord-005081-kxrzv16n	124	12	to	to	IN
cord-005081-kxrzv16n	124	13	constructing	construct	VBG
cord-005081-kxrzv16n	124	14	influenza	influenza	NN
cord-005081-kxrzv16n	124	15	vaccines	vaccine	NNS
cord-005081-kxrzv16n	124	16	,	,	,
cord-005081-kxrzv16n	124	17	it	-PRON-	PRP
cord-005081-kxrzv16n	124	18	is	be	VBZ
cord-005081-kxrzv16n	124	19	more	more	RBR
cord-005081-kxrzv16n	124	20	appropriate	appropriate	JJ
cord-005081-kxrzv16n	124	21	to	to	TO
cord-005081-kxrzv16n	124	22	specify	specify	VB
cord-005081-kxrzv16n	124	23	recombinant	recombinant	JJ
cord-005081-kxrzv16n	124	24	vaccines	vaccine	NNS
cord-005081-kxrzv16n	124	25	by	by	IN
cord-005081-kxrzv16n	124	26	two	two	CD
cord-005081-kxrzv16n	124	27	types	type	NNS
cord-005081-kxrzv16n	124	28	:	:	:
cord-005081-kxrzv16n	124	29	recombinant	recombinant	JJ
cord-005081-kxrzv16n	124	30	influenza	influenza	NN
cord-005081-kxrzv16n	124	31	viruses	virus	NNS
cord-005081-kxrzv16n	124	32	used	use	VBN
cord-005081-kxrzv16n	124	33	as	as	IN
cord-005081-kxrzv16n	124	34	vectors	vector	NNS
cord-005081-kxrzv16n	124	35	or	or	CC
cord-005081-kxrzv16n	124	36	deficient	deficient	JJ
cord-005081-kxrzv16n	124	37	viruses	virus	NNS
cord-005081-kxrzv16n	124	38	for	for	IN
cord-005081-kxrzv16n	124	39	obtaining	obtain	VBG
cord-005081-kxrzv16n	124	40	non	non	JJ
cord-005081-kxrzv16n	124	41	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	124	42	vaccine	vaccine	NN
cord-005081-kxrzv16n	124	43	strains	strain	NNS
cord-005081-kxrzv16n	124	44	and	and	CC
cord-005081-kxrzv16n	124	45	constructs	construct	NNS
cord-005081-kxrzv16n	124	46	bearing	bear	VBG
cord-005081-kxrzv16n	124	47	individual	individual	JJ
cord-005081-kxrzv16n	124	48	viral	viral	JJ
cord-005081-kxrzv16n	124	49	genes	gene	NNS
cord-005081-kxrzv16n	124	50	for	for	IN
cord-005081-kxrzv16n	124	51	obtaining	obtain	VBG
cord-005081-kxrzv16n	124	52	different	different	JJ
cord-005081-kxrzv16n	124	53	types	type	NNS
cord-005081-kxrzv16n	124	54	of	of	IN
cord-005081-kxrzv16n	124	55	vaccines	vaccine	NNS
cord-005081-kxrzv16n	124	56	.	.	.
cord-005081-kxrzv16n	125	1	We	-PRON-	PRP
cord-005081-kxrzv16n	125	2	considered	consider	VBD
cord-005081-kxrzv16n	125	3	above	above	IN
cord-005081-kxrzv16n	125	4	the	the	DT
cord-005081-kxrzv16n	125	5	first	first	JJ
cord-005081-kxrzv16n	125	6	approach	approach	NN
cord-005081-kxrzv16n	125	7	and	and	CC
cord-005081-kxrzv16n	125	8	now	now	RB
cord-005081-kxrzv16n	125	9	we	-PRON-	PRP
cord-005081-kxrzv16n	125	10	consider	consider	VBP
cord-005081-kxrzv16n	125	11	the	the	DT
cord-005081-kxrzv16n	125	12	second	second	JJ
cord-005081-kxrzv16n	125	13	approach	approach	NN
cord-005081-kxrzv16n	125	14	.	.	.
cord-005081-kxrzv16n	126	1	In	in	IN
cord-005081-kxrzv16n	126	2	practice	practice	NN
cord-005081-kxrzv16n	126	3	,	,	,
cord-005081-kxrzv16n	126	4	the	the	DT
cord-005081-kxrzv16n	126	5	process	process	NN
cord-005081-kxrzv16n	126	6	of	of	IN
cord-005081-kxrzv16n	126	7	constructing	construct	VBG
cord-005081-kxrzv16n	126	8	individual	individual	JJ
cord-005081-kxrzv16n	126	9	recombinant	recombinant	JJ
cord-005081-kxrzv16n	126	10	vaccines	vaccine	NNS
cord-005081-kxrzv16n	126	11	comprises	comprise	VBZ
cord-005081-kxrzv16n	126	12	the	the	DT
cord-005081-kxrzv16n	126	13	following	follow	VBG
cord-005081-kxrzv16n	126	14	actions	action	NNS
cord-005081-kxrzv16n	126	15	:	:	:
cord-005081-kxrzv16n	126	16	(	(	-LRB-
cord-005081-kxrzv16n	126	17	1	1	LS
cord-005081-kxrzv16n	126	18	)	)	-RRB-
cord-005081-kxrzv16n	126	19	Cloning	cloning	NN
cord-005081-kxrzv16n	126	20	and	and	CC
cord-005081-kxrzv16n	126	21	expression	expression	NN
cord-005081-kxrzv16n	126	22	of	of	IN
cord-005081-kxrzv16n	126	23	individual	individual	JJ
cord-005081-kxrzv16n	126	24	viral	viral	JJ
cord-005081-kxrzv16n	126	25	genes	gene	NNS
cord-005081-kxrzv16n	126	26	in	in	IN
cord-005081-kxrzv16n	126	27	different	different	JJ
cord-005081-kxrzv16n	126	28	vectors	vector	NNS
cord-005081-kxrzv16n	126	29	to	to	TO
cord-005081-kxrzv16n	126	30	obtain	obtain	VB
cord-005081-kxrzv16n	126	31	viral	viral	JJ
cord-005081-kxrzv16n	126	32	antigens	antigen	NNS
cord-005081-kxrzv16n	126	33	in	in	IN
cord-005081-kxrzv16n	126	34	different	different	JJ
cord-005081-kxrzv16n	126	35	expression	expression	NN
cord-005081-kxrzv16n	126	36	systems	system	NNS
cord-005081-kxrzv16n	126	37	as	as	RB
cord-005081-kxrzv16n	126	38	highly	highly	RB
cord-005081-kxrzv16n	126	39	purified	purify	VBN
cord-005081-kxrzv16n	126	40	vaccine	vaccine	NN
cord-005081-kxrzv16n	126	41	prepara	prepara	NNP
cord-005081-kxrzv16n	126	42	tions	tion	NNS
cord-005081-kxrzv16n	126	43	.	.	.
cord-005081-kxrzv16n	127	1	(	(	-LRB-
cord-005081-kxrzv16n	127	2	2	2	LS
cord-005081-kxrzv16n	127	3	)	)	-RRB-
cord-005081-kxrzv16n	127	4	Cloning	cloning	NN
cord-005081-kxrzv16n	127	5	and	and	CC
cord-005081-kxrzv16n	127	6	expression	expression	NN
cord-005081-kxrzv16n	127	7	of	of	IN
cord-005081-kxrzv16n	127	8	individual	individual	JJ
cord-005081-kxrzv16n	127	9	viral	viral	JJ
cord-005081-kxrzv16n	127	10	anti	anti	JJ
cord-005081-kxrzv16n	127	11	gens	gen	NNS
cord-005081-kxrzv16n	127	12	to	to	TO
cord-005081-kxrzv16n	127	13	obtain	obtain	VB
cord-005081-kxrzv16n	127	14	virus	virus	NN
cord-005081-kxrzv16n	127	15	like	like	IN
cord-005081-kxrzv16n	127	16	particles	particle	NNS
cord-005081-kxrzv16n	127	17	,	,	,
cord-005081-kxrzv16n	127	18	To	to	TO
cord-005081-kxrzv16n	127	19	achieve	achieve	VB
cord-005081-kxrzv16n	127	20	each	each	DT
cord-005081-kxrzv16n	127	21	of	of	IN
cord-005081-kxrzv16n	127	22	the	the	DT
cord-005081-kxrzv16n	127	23	above	above	JJ
cord-005081-kxrzv16n	127	24	results	result	NNS
cord-005081-kxrzv16n	127	25	,	,	,
cord-005081-kxrzv16n	127	26	one	one	CD
cord-005081-kxrzv16n	127	27	is	be	VBZ
cord-005081-kxrzv16n	127	28	to	to	TO
cord-005081-kxrzv16n	127	29	make	make	VB
cord-005081-kxrzv16n	127	30	a	a	DT
cord-005081-kxrzv16n	127	31	well	well	RB
cord-005081-kxrzv16n	127	32	grounded	ground	VBN
cord-005081-kxrzv16n	127	33	selection	selection	NN
cord-005081-kxrzv16n	127	34	.	.	.
cord-005081-kxrzv16n	128	1	The	the	DT
cord-005081-kxrzv16n	128	2	following	follow	VBG
cord-005081-kxrzv16n	128	3	antigen	antigen	NN
cord-005081-kxrzv16n	128	4	proteins	protein	NNS
cord-005081-kxrzv16n	128	5	are	be	VBP
cord-005081-kxrzv16n	128	6	localized	localize	VBN
cord-005081-kxrzv16n	128	7	on	on	IN
cord-005081-kxrzv16n	128	8	a	a	DT
cord-005081-kxrzv16n	128	9	viral	viral	JJ
cord-005081-kxrzv16n	128	10	particle	particle	NN
cord-005081-kxrzv16n	128	11	's	's	POS
cord-005081-kxrzv16n	128	12	surface	surface	NN
cord-005081-kxrzv16n	128	13	:	:	:
cord-005081-kxrzv16n	128	14	haemagglutinin	haemagglutinin	NNP
cord-005081-kxrzv16n	128	15	(	(	-LRB-
cord-005081-kxrzv16n	128	16	HA	HA	NNP
cord-005081-kxrzv16n	128	17	)	)	-RRB-
cord-005081-kxrzv16n	128	18	,	,	,
cord-005081-kxrzv16n	128	19	neuraminidase	neuraminidase	FW
cord-005081-kxrzv16n	128	20	(	(	-LRB-
cord-005081-kxrzv16n	128	21	NA	NA	NNP
cord-005081-kxrzv16n	128	22	)	)	-RRB-
cord-005081-kxrzv16n	128	23	,	,	,
cord-005081-kxrzv16n	128	24	and	and	CC
cord-005081-kxrzv16n	128	25	the	the	DT
cord-005081-kxrzv16n	128	26	M2	M2	NNP
cord-005081-kxrzv16n	128	27	protein	protein	NN
cord-005081-kxrzv16n	128	28	.	.	.
cord-005081-kxrzv16n	129	1	It	-PRON-	PRP
cord-005081-kxrzv16n	129	2	is	be	VBZ
cord-005081-kxrzv16n	129	3	estab	estab	NNP
cord-005081-kxrzv16n	129	4	lished	lishe	VBN
cord-005081-kxrzv16n	129	5	that	that	IN
cord-005081-kxrzv16n	129	6	five	five	CD
cord-005081-kxrzv16n	129	7	antigenic	antigenic	JJ
cord-005081-kxrzv16n	129	8	sites	site	NNS
cord-005081-kxrzv16n	129	9	are	be	VBP
cord-005081-kxrzv16n	129	10	localized	localize	VBN
cord-005081-kxrzv16n	129	11	in	in	IN
cord-005081-kxrzv16n	129	12	the	the	DT
cord-005081-kxrzv16n	129	13	"	"	``
cord-005081-kxrzv16n	129	14	head	head	NN
cord-005081-kxrzv16n	129	15	"	"	''
cord-005081-kxrzv16n	129	16	of	of	IN
cord-005081-kxrzv16n	129	17	the	the	DT
cord-005081-kxrzv16n	129	18	apical	apical	JJ
cord-005081-kxrzv16n	129	19	part	part	NN
cord-005081-kxrzv16n	129	20	of	of	IN
cord-005081-kxrzv16n	129	21	the	the	DT
cord-005081-kxrzv16n	129	22	HA	HA	NNP
cord-005081-kxrzv16n	129	23	molecule	molecule	NN
cord-005081-kxrzv16n	129	24	and	and	CC
cord-005081-kxrzv16n	129	25	that	that	IN
cord-005081-kxrzv16n	129	26	the	the	DT
cord-005081-kxrzv16n	129	27	antibodies	antibody	NNS
cord-005081-kxrzv16n	129	28	'	'	POS
cord-005081-kxrzv16n	129	29	virus	virus	NN
cord-005081-kxrzv16n	129	30	neutralizing	neutralize	VBG
cord-005081-kxrzv16n	129	31	activity	activity	NN
cord-005081-kxrzv16n	129	32	is	be	VBZ
cord-005081-kxrzv16n	129	33	associated	associate	VBN
cord-005081-kxrzv16n	129	34	with	with	IN
cord-005081-kxrzv16n	129	35	the	the	DT
cord-005081-kxrzv16n	129	36	immune	immune	JJ
cord-005081-kxrzv16n	129	37	response	response	NN
cord-005081-kxrzv16n	129	38	to	to	IN
cord-005081-kxrzv16n	129	39	these	these	DT
cord-005081-kxrzv16n	129	40	sites	site	NNS
cord-005081-kxrzv16n	129	41	.	.	.
cord-005081-kxrzv16n	130	1	Antibodies	antibody	NNS
cord-005081-kxrzv16n	130	2	to	to	IN
cord-005081-kxrzv16n	130	3	HA	HA	NNP
cord-005081-kxrzv16n	130	4	block	block	VB
cord-005081-kxrzv16n	130	5	the	the	DT
cord-005081-kxrzv16n	130	6	interaction	interaction	NN
cord-005081-kxrzv16n	130	7	of	of	IN
cord-005081-kxrzv16n	130	8	the	the	DT
cord-005081-kxrzv16n	130	9	virus	virus	NN
cord-005081-kxrzv16n	130	10	with	with	IN
cord-005081-kxrzv16n	130	11	cellular	cellular	JJ
cord-005081-kxrzv16n	130	12	receptors	receptor	NNS
cord-005081-kxrzv16n	130	13	,	,	,
cord-005081-kxrzv16n	130	14	that	that	RB
cord-005081-kxrzv16n	130	15	is	is	RB
cord-005081-kxrzv16n	130	16	,	,	,
cord-005081-kxrzv16n	130	17	infecting	infect	VBG
cord-005081-kxrzv16n	130	18	the	the	DT
cord-005081-kxrzv16n	130	19	cells	cell	NNS
cord-005081-kxrzv16n	130	20	.	.	.
cord-005081-kxrzv16n	131	1	Antibodies	antibody	NNS
cord-005081-kxrzv16n	131	2	to	to	IN
cord-005081-kxrzv16n	131	3	NA	NA	NNP
cord-005081-kxrzv16n	131	4	block	block	VB
cord-005081-kxrzv16n	131	5	the	the	DT
cord-005081-kxrzv16n	131	6	secretion	secretion	NN
cord-005081-kxrzv16n	131	7	of	of	IN
cord-005081-kxrzv16n	131	8	viruses	virus	NNS
cord-005081-kxrzv16n	131	9	by	by	IN
cord-005081-kxrzv16n	131	10	the	the	DT
cord-005081-kxrzv16n	131	11	infected	infected	JJ
cord-005081-kxrzv16n	131	12	cells	cell	NNS
cord-005081-kxrzv16n	131	13	(	(	-LRB-
cord-005081-kxrzv16n	131	14	i.e.	i.e.	FW
cord-005081-kxrzv16n	131	15	,	,	,
cord-005081-kxrzv16n	131	16	propagation	propagation	NN
cord-005081-kxrzv16n	131	17	of	of	IN
cord-005081-kxrzv16n	131	18	infection	infection	NN
cord-005081-kxrzv16n	131	19	)	)	-RRB-
cord-005081-kxrzv16n	131	20	.	.	.
cord-005081-kxrzv16n	132	1	Antibodies	antibody	NNS
cord-005081-kxrzv16n	132	2	to	to	IN
cord-005081-kxrzv16n	132	3	the	the	DT
cord-005081-kxrzv16n	132	4	M2	M2	NNP
cord-005081-kxrzv16n	132	5	pro	pro	NNP
cord-005081-kxrzv16n	132	6	tein	tein	NNP
cord-005081-kxrzv16n	132	7	also	also	RB
cord-005081-kxrzv16n	132	8	considerably	considerably	RB
cord-005081-kxrzv16n	132	9	block	block	VBP
cord-005081-kxrzv16n	132	10	the	the	DT
cord-005081-kxrzv16n	132	11	dissociation	dissociation	NN
cord-005081-kxrzv16n	132	12	of	of	IN
cord-005081-kxrzv16n	132	13	infec	infec	IN
cord-005081-kxrzv16n	132	14	tious	tious	JJ
cord-005081-kxrzv16n	132	15	viral	viral	JJ
cord-005081-kxrzv16n	132	16	particles	particle	NNS
cord-005081-kxrzv16n	132	17	from	from	IN
cord-005081-kxrzv16n	132	18	the	the	DT
cord-005081-kxrzv16n	132	19	infected	infected	JJ
cord-005081-kxrzv16n	132	20	cells	cell	NNS
cord-005081-kxrzv16n	132	21	'	'	POS
cord-005081-kxrzv16n	132	22	mem	mem	NNP
cord-005081-kxrzv16n	132	23	branes	brane	NNS
cord-005081-kxrzv16n	132	24	.	.	.
cord-005081-kxrzv16n	133	1	We	-PRON-	PRP
cord-005081-kxrzv16n	133	2	see	see	VBP
cord-005081-kxrzv16n	133	3	further	further	RB
cord-005081-kxrzv16n	133	4	that	that	IN
cord-005081-kxrzv16n	133	5	,	,	,
cord-005081-kxrzv16n	133	6	of	of	IN
cord-005081-kxrzv16n	133	7	the	the	DT
cord-005081-kxrzv16n	133	8	three	three	CD
cord-005081-kxrzv16n	133	9	main	main	JJ
cord-005081-kxrzv16n	133	10	surface	surface	NN
cord-005081-kxrzv16n	133	11	proteins	protein	NNS
cord-005081-kxrzv16n	133	12	,	,	,
cord-005081-kxrzv16n	133	13	only	only	RB
cord-005081-kxrzv16n	133	14	HA	HA	NNP
cord-005081-kxrzv16n	133	15	is	be	VBZ
cord-005081-kxrzv16n	133	16	of	of	IN
cord-005081-kxrzv16n	133	17	a	a	DT
cord-005081-kxrzv16n	133	18	principal	principal	JJ
cord-005081-kxrzv16n	133	19	significance	significance	NN
cord-005081-kxrzv16n	133	20	,	,	,
cord-005081-kxrzv16n	133	21	the	the	DT
cord-005081-kxrzv16n	133	22	consideration	consideration	NN
cord-005081-kxrzv16n	133	23	of	of	IN
cord-005081-kxrzv16n	133	24	which	which	WDT
cord-005081-kxrzv16n	133	25	the	the	DT
cord-005081-kxrzv16n	133	26	production	production	NN
cord-005081-kxrzv16n	133	27	technology	technology	NN
cord-005081-kxrzv16n	133	28	for	for	IN
cord-005081-kxrzv16n	133	29	subunit	subunit	NN
cord-005081-kxrzv16n	133	30	vaccines	vaccine	NNS
cord-005081-kxrzv16n	133	31	predominantly	predominantly	RB
cord-005081-kxrzv16n	133	32	containing	contain	VBG
cord-005081-kxrzv16n	133	33	HA	HA	NNP
cord-005081-kxrzv16n	133	34	is	be	VBZ
cord-005081-kxrzv16n	133	35	based	base	VBN
cord-005081-kxrzv16n	133	36	.	.	.
cord-005081-kxrzv16n	134	1	Immunity	immunity	NN
cord-005081-kxrzv16n	134	2	to	to	IN
cord-005081-kxrzv16n	134	3	NA	NA	NNP
cord-005081-kxrzv16n	134	4	is	be	VBZ
cord-005081-kxrzv16n	134	5	believed	believe	VBN
cord-005081-kxrzv16n	134	6	to	to	TO
cord-005081-kxrzv16n	134	7	be	be	VB
cord-005081-kxrzv16n	134	8	accessory	accessory	NN
cord-005081-kxrzv16n	134	9	.	.	.
cord-005081-kxrzv16n	135	1	The	the	DT
cord-005081-kxrzv16n	135	2	M2	M2	NNP
cord-005081-kxrzv16n	135	3	protein	protein	NN
cord-005081-kxrzv16n	135	4	,	,	,
cord-005081-kxrzv16n	135	5	considering	consider	VBG
cord-005081-kxrzv16n	135	6	its	-PRON-	PRP$
cord-005081-kxrzv16n	135	7	supreme	supreme	JJ
cord-005081-kxrzv16n	135	8	conserva	conserva	NNP
cord-005081-kxrzv16n	135	9	tiveness	tiveness	NNP
cord-005081-kxrzv16n	135	10	,	,	,
cord-005081-kxrzv16n	135	11	became	become	VBD
cord-005081-kxrzv16n	135	12	the	the	DT
cord-005081-kxrzv16n	135	13	model	model	NN
cord-005081-kxrzv16n	135	14	object	object	NN
cord-005081-kxrzv16n	135	15	for	for	IN
cord-005081-kxrzv16n	135	16	constructing	construct	VBG
cord-005081-kxrzv16n	135	17	a	a	DT
cord-005081-kxrzv16n	135	18	universal	universal	JJ
cord-005081-kxrzv16n	135	19	antiinfluenza	antiinfluenza	NNP
cord-005081-kxrzv16n	135	20	A	a	DT
cord-005081-kxrzv16n	135	21	vaccine	vaccine	NN
cord-005081-kxrzv16n	135	22	.	.	.
cord-005081-kxrzv16n	136	1	Thus	thus	RB
cord-005081-kxrzv16n	136	2	,	,	,
cord-005081-kxrzv16n	136	3	recombinant	recombinant	JJ
cord-005081-kxrzv16n	136	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	136	5	with	with	IN
cord-005081-kxrzv16n	136	6	individual	individual	JJ
cord-005081-kxrzv16n	136	7	com	com	NN
cord-005081-kxrzv16n	136	8	ponents	ponent	NNS
cord-005081-kxrzv16n	136	9	of	of	IN
cord-005081-kxrzv16n	136	10	influenza	influenza	NN
cord-005081-kxrzv16n	136	11	type	type	NN
cord-005081-kxrzv16n	136	12	A	a	NN
cord-005081-kxrzv16n	136	13	viruses	virus	NNS
cord-005081-kxrzv16n	136	14	are	be	VBP
cord-005081-kxrzv16n	136	15	mainly	mainly	RB
cord-005081-kxrzv16n	136	16	ori	ori	NNP
cord-005081-kxrzv16n	136	17	ented	ente	VBN
cord-005081-kxrzv16n	136	18	to	to	IN
cord-005081-kxrzv16n	136	19	the	the	DT
cord-005081-kxrzv16n	136	20	key	key	JJ
cord-005081-kxrzv16n	136	21	and	and	CC
cord-005081-kxrzv16n	136	22	highly	highly	RB
cord-005081-kxrzv16n	136	23	variable	variable	JJ
cord-005081-kxrzv16n	136	24	viral	viral	JJ
cord-005081-kxrzv16n	136	25	compo	compo	NN
cord-005081-kxrzv16n	136	26	nent	nent	JJ
cord-005081-kxrzv16n	136	27	-	-	:
cord-005081-kxrzv16n	136	28	the	the	DT
cord-005081-kxrzv16n	136	29	HA	HA	NNP
cord-005081-kxrzv16n	136	30	molecule	molecule	NN
cord-005081-kxrzv16n	136	31	.	.	.
cord-005081-kxrzv16n	137	1	Among	among	IN
cord-005081-kxrzv16n	137	2	the	the	DT
cord-005081-kxrzv16n	137	3	internal	internal	JJ
cord-005081-kxrzv16n	137	4	antigens	antigen	NNS
cord-005081-kxrzv16n	137	5	of	of	IN
cord-005081-kxrzv16n	137	6	a	a	DT
cord-005081-kxrzv16n	137	7	viral	viral	JJ
cord-005081-kxrzv16n	137	8	particle	particle	NN
cord-005081-kxrzv16n	137	9	,	,	,
cord-005081-kxrzv16n	137	10	the	the	DT
cord-005081-kxrzv16n	137	11	NP	NP	NNP
cord-005081-kxrzv16n	137	12	,	,	,
cord-005081-kxrzv16n	137	13	M1	M1	NNP
cord-005081-kxrzv16n	137	14	,	,	,
cord-005081-kxrzv16n	137	15	and	and	CC
cord-005081-kxrzv16n	137	16	NS1	ns1	NN
cord-005081-kxrzv16n	137	17	proteins	protein	NNS
cord-005081-kxrzv16n	137	18	are	be	VBP
cord-005081-kxrzv16n	137	19	considered	consider	VBN
cord-005081-kxrzv16n	137	20	as	as	IN
cord-005081-kxrzv16n	137	21	material	material	NN
cord-005081-kxrzv16n	137	22	for	for	IN
cord-005081-kxrzv16n	137	23	obtaining	obtain	VBG
cord-005081-kxrzv16n	137	24	vaccines	vaccine	NNS
cord-005081-kxrzv16n	137	25	.	.	.
cord-005081-kxrzv16n	138	1	Another	another	DT
cord-005081-kxrzv16n	138	2	,	,	,
cord-005081-kxrzv16n	138	3	no	no	DT
cord-005081-kxrzv16n	138	4	less	less	RBR
cord-005081-kxrzv16n	138	5	important	important	JJ
cord-005081-kxrzv16n	138	6	problem	problem	NN
cord-005081-kxrzv16n	138	7	consists	consist	VBZ
cord-005081-kxrzv16n	138	8	in	in	IN
cord-005081-kxrzv16n	138	9	selecting	select	VBG
cord-005081-kxrzv16n	138	10	a	a	DT
cord-005081-kxrzv16n	138	11	substrate	substrate	NN
cord-005081-kxrzv16n	138	12	for	for	IN
cord-005081-kxrzv16n	138	13	growing	grow	VBG
cord-005081-kxrzv16n	138	14	antigenic	antigenic	JJ
cord-005081-kxrzv16n	138	15	substances	substance	NNS
cord-005081-kxrzv16n	138	16	.	.	.
cord-005081-kxrzv16n	139	1	Scientists	scientist	NNS
cord-005081-kxrzv16n	139	2	have	have	VBP
cord-005081-kxrzv16n	139	3	been	be	VBN
cord-005081-kxrzv16n	139	4	discussing	discuss	VBG
cord-005081-kxrzv16n	139	5	for	for	IN
cord-005081-kxrzv16n	139	6	many	many	JJ
cord-005081-kxrzv16n	139	7	years	year	NNS
cord-005081-kxrzv16n	139	8	the	the	DT
cord-005081-kxrzv16n	139	9	option	option	NN
cord-005081-kxrzv16n	139	10	of	of	IN
cord-005081-kxrzv16n	139	11	replacing	replace	VBG
cord-005081-kxrzv16n	139	12	chicken	chicken	NN
cord-005081-kxrzv16n	139	13	embryos	embryo	NNS
cord-005081-kxrzv16n	139	14	with	with	IN
cord-005081-kxrzv16n	139	15	cell	cell	NN
cord-005081-kxrzv16n	139	16	cul	cul	NN
cord-005081-kxrzv16n	139	17	tures	ture	NNS
cord-005081-kxrzv16n	139	18	.	.	.
cord-005081-kxrzv16n	140	1	As	as	IN
cord-005081-kxrzv16n	140	2	previously	previously	RB
cord-005081-kxrzv16n	140	3	,	,	,
cord-005081-kxrzv16n	140	4	conventional	conventional	JJ
cord-005081-kxrzv16n	140	5	technologies	technology	NNS
cord-005081-kxrzv16n	140	6	are	be	VBP
cord-005081-kxrzv16n	140	7	oriented	orient	VBN
cord-005081-kxrzv16n	140	8	to	to	IN
cord-005081-kxrzv16n	140	9	growing	grow	VBG
cord-005081-kxrzv16n	140	10	viral	viral	JJ
cord-005081-kxrzv16n	140	11	material	material	NN
cord-005081-kxrzv16n	140	12	on	on	IN
cord-005081-kxrzv16n	140	13	chicken	chicken	NN
cord-005081-kxrzv16n	140	14	embryos	embryo	NNS
cord-005081-kxrzv16n	140	15	.	.	.
cord-005081-kxrzv16n	141	1	It	-PRON-	PRP
cord-005081-kxrzv16n	141	2	applies	apply	VBZ
cord-005081-kxrzv16n	141	3	to	to	IN
cord-005081-kxrzv16n	141	4	LAIV	LAIV	NNP
cord-005081-kxrzv16n	141	5	and	and	CC
cord-005081-kxrzv16n	141	6	IIV	IIV	NNP
cord-005081-kxrzv16n	141	7	of	of	IN
cord-005081-kxrzv16n	141	8	the	the	DT
cord-005081-kxrzv16n	141	9	current	current	JJ
cord-005081-kxrzv16n	141	10	generations	generation	NNS
cord-005081-kxrzv16n	141	11	.	.	.
cord-005081-kxrzv16n	142	1	This	this	DT
cord-005081-kxrzv16n	142	2	technological	technological	JJ
cord-005081-kxrzv16n	142	3	process	process	NN
cord-005081-kxrzv16n	142	4	consumes	consume	VBZ
cord-005081-kxrzv16n	142	5	millions	million	NNS
cord-005081-kxrzv16n	142	6	of	of	IN
cord-005081-kxrzv16n	142	7	chicken	chicken	NN
cord-005081-kxrzv16n	142	8	embryos	embryo	NNS
cord-005081-kxrzv16n	142	9	(	(	-LRB-
cord-005081-kxrzv16n	142	10	in	in	IN
cord-005081-kxrzv16n	142	11	fact	fact	NN
cord-005081-kxrzv16n	142	12	,	,	,
cord-005081-kxrzv16n	142	13	one	one	CD
cord-005081-kxrzv16n	142	14	dose	dose	NN
cord-005081-kxrzv16n	142	15	of	of	IN
cord-005081-kxrzv16n	142	16	a	a	DT
cord-005081-kxrzv16n	142	17	sea	sea	NN
cord-005081-kxrzv16n	142	18	sonal	sonal	JJ
cord-005081-kxrzv16n	142	19	influenza	influenza	NN
cord-005081-kxrzv16n	142	20	vaccine	vaccine	NN
cord-005081-kxrzv16n	142	21	is	be	VBZ
cord-005081-kxrzv16n	142	22	equivalent	equivalent	JJ
cord-005081-kxrzv16n	142	23	to	to	IN
cord-005081-kxrzv16n	142	24	one	one	CD
cord-005081-kxrzv16n	142	25	embryo	embryo	NN
cord-005081-kxrzv16n	142	26	)	)	-RRB-
cord-005081-kxrzv16n	142	27	.	.	.
cord-005081-kxrzv16n	143	1	The	the	DT
cord-005081-kxrzv16n	143	2	scale	scale	NN
cord-005081-kxrzv16n	143	3	of	of	IN
cord-005081-kxrzv16n	143	4	the	the	DT
cord-005081-kxrzv16n	143	5	problem	problem	NN
cord-005081-kxrzv16n	143	6	is	be	VBZ
cord-005081-kxrzv16n	143	7	realized	realize	VBN
cord-005081-kxrzv16n	143	8	by	by	IN
cord-005081-kxrzv16n	143	9	everyone	everyone	NN
cord-005081-kxrzv16n	143	10	,	,	,
cord-005081-kxrzv16n	143	11	if	if	IN
cord-005081-kxrzv16n	143	12	to	to	TO
cord-005081-kxrzv16n	143	13	consider	consider	VB
cord-005081-kxrzv16n	143	14	that	that	IN
cord-005081-kxrzv16n	143	15	in	in	IN
cord-005081-kxrzv16n	143	16	the	the	DT
cord-005081-kxrzv16n	143	17	event	event	NN
cord-005081-kxrzv16n	143	18	of	of	IN
cord-005081-kxrzv16n	143	19	a	a	DT
cord-005081-kxrzv16n	143	20	pandemic	pandemic	NN
cord-005081-kxrzv16n	143	21	only	only	RB
cord-005081-kxrzv16n	143	22	in	in	IN
cord-005081-kxrzv16n	143	23	Russia	Russia	NNP
cord-005081-kxrzv16n	143	24	the	the	DT
cord-005081-kxrzv16n	143	25	demand	demand	NN
cord-005081-kxrzv16n	143	26	for	for	IN
cord-005081-kxrzv16n	143	27	vaccines	vaccine	NNS
cord-005081-kxrzv16n	143	28	accounts	account	VBZ
cord-005081-kxrzv16n	143	29	for	for	IN
cord-005081-kxrzv16n	143	30	at	at	RB
cord-005081-kxrzv16n	143	31	least	least	RBS
cord-005081-kxrzv16n	143	32	100	100	CD
cord-005081-kxrzv16n	143	33	mil	mil	NN
cord-005081-kxrzv16n	143	34	lion	lion	NN
cord-005081-kxrzv16n	143	35	doses	dose	NNS
cord-005081-kxrzv16n	143	36	.	.	.
cord-005081-kxrzv16n	144	1	This	this	DT
cord-005081-kxrzv16n	144	2	scale	scale	NN
cord-005081-kxrzv16n	144	3	of	of	IN
cord-005081-kxrzv16n	144	4	mass	mass	NN
cord-005081-kxrzv16n	144	5	production	production	NN
cord-005081-kxrzv16n	144	6	relying	rely	VBG
cord-005081-kxrzv16n	144	7	on	on	IN
cord-005081-kxrzv16n	144	8	the	the	DT
cord-005081-kxrzv16n	144	9	conventional	conventional	JJ
cord-005081-kxrzv16n	144	10	substrate	substrate	NN
cord-005081-kxrzv16n	144	11	can	can	MD
cord-005081-kxrzv16n	144	12	not	not	RB
cord-005081-kxrzv16n	144	13	be	be	VB
cord-005081-kxrzv16n	144	14	promptly	promptly	RB
cord-005081-kxrzv16n	144	15	deployed	deploy	VBN
cord-005081-kxrzv16n	144	16	(	(	-LRB-
cord-005081-kxrzv16n	144	17	by	by	IN
cord-005081-kxrzv16n	144	18	the	the	DT
cord-005081-kxrzv16n	144	19	coming	coming	NN
cord-005081-kxrzv16n	144	20	of	of	IN
cord-005081-kxrzv16n	144	21	a	a	DT
cord-005081-kxrzv16n	144	22	season	season	NN
cord-005081-kxrzv16n	144	23	and	and	CC
cord-005081-kxrzv16n	144	24	more	more	JJR
cord-005081-kxrzv16n	144	25	so	so	RB
cord-005081-kxrzv16n	144	26	by	by	IN
cord-005081-kxrzv16n	144	27	the	the	DT
cord-005081-kxrzv16n	144	28	outbreak	outbreak	NN
cord-005081-kxrzv16n	144	29	of	of	IN
cord-005081-kxrzv16n	144	30	a	a	DT
cord-005081-kxrzv16n	144	31	pandemic	pandemic	NN
cord-005081-kxrzv16n	144	32	)	)	-RRB-
cord-005081-kxrzv16n	144	33	.	.	.
cord-005081-kxrzv16n	145	1	The	the	DT
cord-005081-kxrzv16n	145	2	use	use	NN
cord-005081-kxrzv16n	145	3	of	of	IN
cord-005081-kxrzv16n	145	4	cell	cell	NN
cord-005081-kxrzv16n	145	5	cultures	culture	NNS
cord-005081-kxrzv16n	145	6	in	in	IN
cord-005081-kxrzv16n	145	7	producing	produce	VBG
cord-005081-kxrzv16n	145	8	antigenic	antigenic	JJ
cord-005081-kxrzv16n	145	9	components	component	NNS
cord-005081-kxrzv16n	145	10	of	of	IN
cord-005081-kxrzv16n	145	11	vaccines	vaccine	NNS
cord-005081-kxrzv16n	145	12	allows	allow	VBZ
cord-005081-kxrzv16n	145	13	specialists	specialist	NNS
cord-005081-kxrzv16n	145	14	to	to	TO
cord-005081-kxrzv16n	145	15	decide	decide	VB
cord-005081-kxrzv16n	145	16	the	the	DT
cord-005081-kxrzv16n	145	17	above	above	JJ
cord-005081-kxrzv16n	145	18	task	task	NN
cord-005081-kxrzv16n	145	19	rapidly	rapidly	RB
cord-005081-kxrzv16n	145	20	and	and	CC
cord-005081-kxrzv16n	145	21	in	in	IN
cord-005081-kxrzv16n	145	22	sizable	sizable	JJ
cord-005081-kxrzv16n	145	23	volumes	volume	NNS
cord-005081-kxrzv16n	145	24	.	.	.
cord-005081-kxrzv16n	146	1	Vaccine	vaccine	NN
cord-005081-kxrzv16n	146	2	production	production	NN
cord-005081-kxrzv16n	146	3	based	base	VBN
cord-005081-kxrzv16n	146	4	on	on	IN
cord-005081-kxrzv16n	146	5	the	the	DT
cord-005081-kxrzv16n	146	6	Vero	Vero	NNP
cord-005081-kxrzv16n	146	7	and	and	CC
cord-005081-kxrzv16n	146	8	MDCK	MDCK	NNP
cord-005081-kxrzv16n	146	9	cell	cell	NN
cord-005081-kxrzv16n	146	10	cultures	culture	NNS
cord-005081-kxrzv16n	146	11	have	have	VBP
cord-005081-kxrzv16n	146	12	already	already	RB
cord-005081-kxrzv16n	146	13	been	be	VBN
cord-005081-kxrzv16n	146	14	licensed	license	VBN
cord-005081-kxrzv16n	146	15	in	in	IN
cord-005081-kxrzv16n	146	16	the	the	DT
cord-005081-kxrzv16n	146	17	United	United	NNP
cord-005081-kxrzv16n	146	18	States	States	NNP
cord-005081-kxrzv16n	146	19	and	and	CC
cord-005081-kxrzv16n	146	20	European	european	JJ
cord-005081-kxrzv16n	146	21	countries	country	NNS
cord-005081-kxrzv16n	146	22	.	.	.
cord-005081-kxrzv16n	147	1	Moreover	moreover	RB
cord-005081-kxrzv16n	147	2	,	,	,
cord-005081-kxrzv16n	147	3	the	the	DT
cord-005081-kxrzv16n	147	4	use	use	NN
cord-005081-kxrzv16n	147	5	of	of	IN
cord-005081-kxrzv16n	147	6	this	this	DT
cord-005081-kxrzv16n	147	7	approach	approach	NN
cord-005081-kxrzv16n	147	8	is	be	VBZ
cord-005081-kxrzv16n	147	9	in	in	IN
cord-005081-kxrzv16n	147	10	full	full	JJ
cord-005081-kxrzv16n	147	11	correspondence	correspondence	NN
cord-005081-kxrzv16n	147	12	with	with	IN
cord-005081-kxrzv16n	147	13	the	the	DT
cord-005081-kxrzv16n	147	14	complete	complete	JJ
cord-005081-kxrzv16n	147	15	technological	technological	JJ
cord-005081-kxrzv16n	147	16	chain	chain	NN
cord-005081-kxrzv16n	147	17	for	for	IN
cord-005081-kxrzv16n	147	18	obtaining	obtain	VBG
cord-005081-kxrzv16n	147	19	recombinant	recombinant	JJ
cord-005081-kxrzv16n	147	20	viruses	virus	NNS
cord-005081-kxrzv16n	147	21	using	use	VBG
cord-005081-kxrzv16n	147	22	the	the	DT
cord-005081-kxrzv16n	147	23	8	8	CD
cord-005081-kxrzv16n	147	24	plasmid	plasmid	NN
cord-005081-kxrzv16n	147	25	technique	technique	NN
cord-005081-kxrzv16n	147	26	and	and	CC
cord-005081-kxrzv16n	147	27	,	,	,
cord-005081-kxrzv16n	147	28	in	in	IN
cord-005081-kxrzv16n	147	29	fact	fact	NN
cord-005081-kxrzv16n	147	30	,	,	,
cord-005081-kxrzv16n	147	31	it	-PRON-	PRP
cord-005081-kxrzv16n	147	32	allows	allow	VBZ
cord-005081-kxrzv16n	147	33	producers	producer	NNS
cord-005081-kxrzv16n	147	34	to	to	TO
cord-005081-kxrzv16n	147	35	rapidly	rapidly	RB
cord-005081-kxrzv16n	147	36	deploy	deploy	VB
cord-005081-kxrzv16n	147	37	mass	mass	JJ
cord-005081-kxrzv16n	147	38	production	production	NN
cord-005081-kxrzv16n	147	39	from	from	IN
cord-005081-kxrzv16n	147	40	the	the	DT
cord-005081-kxrzv16n	147	41	laboratory	laboratory	NN
cord-005081-kxrzv16n	147	42	scale	scale	NN
cord-005081-kxrzv16n	147	43	capacity	capacity	NN
cord-005081-kxrzv16n	147	44	.	.	.
cord-005081-kxrzv16n	148	1	In	in	IN
cord-005081-kxrzv16n	148	2	the	the	DT
cord-005081-kxrzv16n	148	3	last	last	JJ
cord-005081-kxrzv16n	148	4	7	7	CD
cord-005081-kxrzv16n	148	5	or	or	CC
cord-005081-kxrzv16n	148	6	8	8	CD
cord-005081-kxrzv16n	148	7	years	year	NNS
cord-005081-kxrzv16n	148	8	,	,	,
cord-005081-kxrzv16n	148	9	can	can	MD
cord-005081-kxrzv16n	148	10	didate	didate	VB
cord-005081-kxrzv16n	148	11	vaccine	vaccine	NN
cord-005081-kxrzv16n	148	12	strains	strain	NNS
cord-005081-kxrzv16n	148	13	for	for	IN
cord-005081-kxrzv16n	148	14	a	a	DT
cord-005081-kxrzv16n	148	15	majority	majority	NN
cord-005081-kxrzv16n	148	16	of	of	IN
cord-005081-kxrzv16n	148	17	seasonal	seasonal	JJ
cord-005081-kxrzv16n	148	18	viruses	virus	NNS
cord-005081-kxrzv16n	148	19	have	have	VBP
cord-005081-kxrzv16n	148	20	already	already	RB
cord-005081-kxrzv16n	148	21	been	be	VBN
cord-005081-kxrzv16n	148	22	obtained	obtain	VBN
cord-005081-kxrzv16n	148	23	using	use	VBG
cord-005081-kxrzv16n	148	24	the	the	DT
cord-005081-kxrzv16n	148	25	so	so	RB
cord-005081-kxrzv16n	148	26	called	call	VBN
cord-005081-kxrzv16n	148	27	reverse	reverse	JJ
cord-005081-kxrzv16n	148	28	genetics	genetics	NN
cord-005081-kxrzv16n	148	29	technique	technique	NN
cord-005081-kxrzv16n	148	30	(	(	-LRB-
cord-005081-kxrzv16n	148	31	see	see	VB
cord-005081-kxrzv16n	148	32	the	the	DT
cord-005081-kxrzv16n	148	33	above	above	JJ
cord-005081-kxrzv16n	148	34	description	description	NN
cord-005081-kxrzv16n	148	35	)	)	-RRB-
cord-005081-kxrzv16n	148	36	.	.	.
cord-005081-kxrzv16n	149	1	This	this	DT
cord-005081-kxrzv16n	149	2	approach	approach	NN
cord-005081-kxrzv16n	149	3	corresponds	correspond	VBZ
cord-005081-kxrzv16n	149	4	also	also	RB
cord-005081-kxrzv16n	149	5	with	with	IN
cord-005081-kxrzv16n	149	6	the	the	DT
cord-005081-kxrzv16n	149	7	DNA	dna	NN
cord-005081-kxrzv16n	149	8	vaccine	vaccine	NN
cord-005081-kxrzv16n	149	9	technology	technology	NN
cord-005081-kxrzv16n	149	10	.	.	.
cord-005081-kxrzv16n	150	1	Although	although	IN
cord-005081-kxrzv16n	150	2	DNA	dna	NN
cord-005081-kxrzv16n	150	3	vaccines	vaccine	NNS
cord-005081-kxrzv16n	150	4	have	have	VBP
cord-005081-kxrzv16n	150	5	been	be	VBN
cord-005081-kxrzv16n	150	6	under	under	IN
cord-005081-kxrzv16n	150	7	development	development	NN
cord-005081-kxrzv16n	150	8	for	for	IN
cord-005081-kxrzv16n	150	9	more	more	JJR
cord-005081-kxrzv16n	150	10	than	than	IN
cord-005081-kxrzv16n	150	11	15	15	CD
cord-005081-kxrzv16n	150	12	years	year	NNS
cord-005081-kxrzv16n	150	13	(	(	-LRB-
cord-005081-kxrzv16n	150	14	their	-PRON-	PRP$
cord-005081-kxrzv16n	150	15	develop	develop	VB
cord-005081-kxrzv16n	150	16	ment	ment	NN
cord-005081-kxrzv16n	150	17	continues	continue	VBZ
cord-005081-kxrzv16n	150	18	)	)	-RRB-
cord-005081-kxrzv16n	151	1	none	none	NN
cord-005081-kxrzv16n	151	2	of	of	IN
cord-005081-kxrzv16n	151	3	such	such	JJ
cord-005081-kxrzv16n	151	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	151	5	are	be	VBP
cord-005081-kxrzv16n	151	6	so	so	RB
cord-005081-kxrzv16n	151	7	far	far	RB
cord-005081-kxrzv16n	151	8	per	per	IN
cord-005081-kxrzv16n	151	9	mitted	mitte	VBN
cord-005081-kxrzv16n	151	10	for	for	IN
cord-005081-kxrzv16n	151	11	use	use	NN
cord-005081-kxrzv16n	151	12	.	.	.
cord-005081-kxrzv16n	152	1	A	a	DT
cord-005081-kxrzv16n	152	2	marked	mark	VBN
cord-005081-kxrzv16n	152	3	breakthrough	breakthrough	NN
cord-005081-kxrzv16n	152	4	in	in	IN
cord-005081-kxrzv16n	152	5	the	the	DT
cord-005081-kxrzv16n	152	6	construction	construction	NN
cord-005081-kxrzv16n	152	7	of	of	IN
cord-005081-kxrzv16n	152	8	recombinant	recombinant	JJ
cord-005081-kxrzv16n	152	9	vaccines	vaccine	NNS
cord-005081-kxrzv16n	152	10	is	be	VBZ
cord-005081-kxrzv16n	152	11	related	relate	VBN
cord-005081-kxrzv16n	152	12	to	to	IN
cord-005081-kxrzv16n	152	13	the	the	DT
cord-005081-kxrzv16n	152	14	use	use	NN
cord-005081-kxrzv16n	152	15	of	of	IN
cord-005081-kxrzv16n	152	16	insect	insect	NN
cord-005081-kxrzv16n	152	17	cells	cell	NNS
cord-005081-kxrzv16n	152	18	and	and	CC
cord-005081-kxrzv16n	152	19	the	the	DT
cord-005081-kxrzv16n	152	20	obtaining	obtaining	NN
cord-005081-kxrzv16n	152	21	of	of	IN
cord-005081-kxrzv16n	152	22	virus	virus	NN
cord-005081-kxrzv16n	152	23	like	like	IN
cord-005081-kxrzv16n	152	24	particles	particle	NNS
cord-005081-kxrzv16n	152	25	(	(	-LRB-
cord-005081-kxrzv16n	152	26	VLPs	vlps	NN
cord-005081-kxrzv16n	152	27	)	)	-RRB-
cord-005081-kxrzv16n	152	28	based	base	VBN
cord-005081-kxrzv16n	152	29	on	on	IN
cord-005081-kxrzv16n	152	30	baculovirus	baculovirus	NNP
cord-005081-kxrzv16n	152	31	expression	expression	NN
cord-005081-kxrzv16n	152	32	vectors	vector	NNS
cord-005081-kxrzv16n	152	33	.	.	.
cord-005081-kxrzv16n	153	1	This	this	DT
cord-005081-kxrzv16n	153	2	tech	tech	NN
cord-005081-kxrzv16n	153	3	nique	nique	NN
cord-005081-kxrzv16n	153	4	deserves	deserve	VBZ
cord-005081-kxrzv16n	153	5	our	-PRON-	PRP$
cord-005081-kxrzv16n	153	6	consideration	consideration	NN
cord-005081-kxrzv16n	153	7	in	in	IN
cord-005081-kxrzv16n	153	8	detail	detail	NN
cord-005081-kxrzv16n	153	9	because	because	IN
cord-005081-kxrzv16n	153	10	of	of	IN
cord-005081-kxrzv16n	153	11	the	the	DT
cord-005081-kxrzv16n	153	12	high	high	JJ
cord-005081-kxrzv16n	153	13	technological	technological	JJ
cord-005081-kxrzv16n	153	14	and	and	CC
cord-005081-kxrzv16n	153	15	quality	quality	NN
cord-005081-kxrzv16n	153	16	indicators	indicator	NNS
cord-005081-kxrzv16n	153	17	demon	demon	NN
cord-005081-kxrzv16n	153	18	strated	strate	VBN
cord-005081-kxrzv16n	153	19	by	by	IN
cord-005081-kxrzv16n	153	20	vaccine	vaccine	NN
cord-005081-kxrzv16n	153	21	preparations	preparation	NNS
cord-005081-kxrzv16n	153	22	.	.	.
cord-005081-kxrzv16n	154	1	Best	good	JJS
cord-005081-kxrzv16n	154	2	solutions	solution	NNS
cord-005081-kxrzv16n	154	3	on	on	IN
cord-005081-kxrzv16n	154	4	the	the	DT
cord-005081-kxrzv16n	154	5	composition	composition	NN
cord-005081-kxrzv16n	154	6	of	of	IN
cord-005081-kxrzv16n	154	7	vaccines	vaccine	NNS
cord-005081-kxrzv16n	154	8	,	,	,
cord-005081-kxrzv16n	154	9	their	-PRON-	PRP$
cord-005081-kxrzv16n	154	10	technologies	technology	NNS
cord-005081-kxrzv16n	154	11	,	,	,
cord-005081-kxrzv16n	154	12	high	high	JJ
cord-005081-kxrzv16n	154	13	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	154	14	,	,	,
cord-005081-kxrzv16n	154	15	and	and	CC
cord-005081-kxrzv16n	154	16	safety	safety	NN
cord-005081-kxrzv16n	154	17	are	be	VBP
cord-005081-kxrzv16n	154	18	actually	actually	RB
cord-005081-kxrzv16n	154	19	united	unite	VBN
cord-005081-kxrzv16n	154	20	under	under	IN
cord-005081-kxrzv16n	154	21	the	the	DT
cord-005081-kxrzv16n	154	22	project	project	NN
cord-005081-kxrzv16n	154	23	.	.	.
cord-005081-kxrzv16n	155	1	In	in	IN
cord-005081-kxrzv16n	155	2	accordance	accordance	NN
cord-005081-kxrzv16n	155	3	with	with	IN
cord-005081-kxrzv16n	155	4	the	the	DT
cord-005081-kxrzv16n	155	5	classification	classification	NN
cord-005081-kxrzv16n	155	6	pre	pre	VBD
cord-005081-kxrzv16n	155	7	sented	sente	VBN
cord-005081-kxrzv16n	155	8	,	,	,
cord-005081-kxrzv16n	155	9	thanks	thank	NNS
cord-005081-kxrzv16n	155	10	to	to	IN
cord-005081-kxrzv16n	155	11	the	the	DT
cord-005081-kxrzv16n	155	12	absence	absence	NN
cord-005081-kxrzv16n	155	13	of	of	IN
cord-005081-kxrzv16n	155	14	ballast	ballast	NN
cord-005081-kxrzv16n	155	15	components	component	NNS
cord-005081-kxrzv16n	155	16	and	and	CC
cord-005081-kxrzv16n	155	17	preservation	preservation	NN
cord-005081-kxrzv16n	155	18	of	of	IN
cord-005081-kxrzv16n	155	19	the	the	DT
cord-005081-kxrzv16n	155	20	spatial	spatial	JJ
cord-005081-kxrzv16n	155	21	structure	structure	NN
cord-005081-kxrzv16n	155	22	of	of	IN
cord-005081-kxrzv16n	155	23	surface	surface	NN
cord-005081-kxrzv16n	155	24	antigens	antigen	NNS
cord-005081-kxrzv16n	155	25	,	,	,
cord-005081-kxrzv16n	155	26	VLPs	vlp	NNS
cord-005081-kxrzv16n	155	27	excel	excel	VBP
cord-005081-kxrzv16n	155	28	recombinant	recombinant	JJ
cord-005081-kxrzv16n	155	29	vaccines	vaccine	NNS
cord-005081-kxrzv16n	155	30	,	,	,
cord-005081-kxrzv16n	155	31	DNA	dna	NN
cord-005081-kxrzv16n	155	32	vectors	vector	NNS
cord-005081-kxrzv16n	155	33	based	base	VBN
cord-005081-kxrzv16n	155	34	vaccines	vaccine	NNS
cord-005081-kxrzv16n	155	35	,	,	,
cord-005081-kxrzv16n	155	36	and	and	CC
cord-005081-kxrzv16n	155	37	whole	whole	JJ
cord-005081-kxrzv16n	155	38	virion	virion	NN
cord-005081-kxrzv16n	155	39	vaccines	vaccine	NNS
cord-005081-kxrzv16n	155	40	grown	grow	VBN
cord-005081-kxrzv16n	155	41	on	on	IN
cord-005081-kxrzv16n	155	42	a	a	DT
cord-005081-kxrzv16n	155	43	cell	cell	NN
cord-005081-kxrzv16n	155	44	substrate	substrate	NN
cord-005081-kxrzv16n	155	45	.	.	.
cord-005081-kxrzv16n	156	1	A	a	DT
cord-005081-kxrzv16n	156	2	positive	positive	JJ
cord-005081-kxrzv16n	156	3	advantage	advantage	NN
cord-005081-kxrzv16n	156	4	is	be	VBZ
cord-005081-kxrzv16n	156	5	,	,	,
cord-005081-kxrzv16n	156	6	evi	evi	NNP
cord-005081-kxrzv16n	156	7	dently	dently	NNP
cord-005081-kxrzv16n	156	8	,	,	,
cord-005081-kxrzv16n	156	9	that	that	IN
cord-005081-kxrzv16n	156	10	the	the	DT
cord-005081-kxrzv16n	156	11	sizes	size	NNS
cord-005081-kxrzv16n	156	12	of	of	IN
cord-005081-kxrzv16n	156	13	VLPs	vlp	NNS
cord-005081-kxrzv16n	156	14	and	and	CC
cord-005081-kxrzv16n	156	15	virions	virion	NNS
cord-005081-kxrzv16n	156	16	also	also	RB
cord-005081-kxrzv16n	156	17	corre	corre	NNP
cord-005081-kxrzv16n	156	18	spond	spond	NNP
cord-005081-kxrzv16n	156	19	.	.	.
cord-005081-kxrzv16n	157	1	We	-PRON-	PRP
cord-005081-kxrzv16n	157	2	will	will	MD
cord-005081-kxrzv16n	157	3	consider	consider	VB
cord-005081-kxrzv16n	157	4	,	,	,
cord-005081-kxrzv16n	157	5	one	one	CD
cord-005081-kxrzv16n	157	6	by	by	IN
cord-005081-kxrzv16n	157	7	one	one	CD
cord-005081-kxrzv16n	157	8	,	,	,
cord-005081-kxrzv16n	157	9	projects	project	NNS
cord-005081-kxrzv16n	157	10	and	and	CC
cord-005081-kxrzv16n	157	11	achieve	achieve	VB
cord-005081-kxrzv16n	157	12	ments	ment	NNS
cord-005081-kxrzv16n	157	13	in	in	IN
cord-005081-kxrzv16n	157	14	the	the	DT
cord-005081-kxrzv16n	157	15	field	field	NN
cord-005081-kxrzv16n	157	16	of	of	IN
cord-005081-kxrzv16n	157	17	new	new	JJ
cord-005081-kxrzv16n	157	18	approaches	approach	NNS
cord-005081-kxrzv16n	157	19	to	to	IN
cord-005081-kxrzv16n	157	20	constructing	construct	VBG
cord-005081-kxrzv16n	157	21	influenza	influenza	NN
cord-005081-kxrzv16n	157	22	vaccines	vaccine	NNS
cord-005081-kxrzv16n	157	23	and	and	CC
cord-005081-kxrzv16n	157	24	the	the	DT
cord-005081-kxrzv16n	157	25	use	use	NN
cord-005081-kxrzv16n	157	26	of	of	IN
cord-005081-kxrzv16n	157	27	different	different	JJ
cord-005081-kxrzv16n	157	28	systems	system	NNS
cord-005081-kxrzv16n	157	29	for	for	IN
cord-005081-kxrzv16n	157	30	their	-PRON-	PRP$
cord-005081-kxrzv16n	157	31	production	production	NN
cord-005081-kxrzv16n	157	32	.	.	.
cord-005081-kxrzv16n	158	1	We	-PRON-	PRP
cord-005081-kxrzv16n	158	2	will	will	MD
cord-005081-kxrzv16n	158	3	discuss	discuss	VB
cord-005081-kxrzv16n	158	4	the	the	DT
cord-005081-kxrzv16n	158	5	projects	project	NNS
cord-005081-kxrzv16n	158	6	that	that	WDT
cord-005081-kxrzv16n	158	7	are	be	VBP
cord-005081-kxrzv16n	158	8	now	now	RB
cord-005081-kxrzv16n	158	9	believed	believe	VBN
cord-005081-kxrzv16n	158	10	to	to	TO
cord-005081-kxrzv16n	158	11	be	be	VB
cord-005081-kxrzv16n	158	12	the	the	DT
cord-005081-kxrzv16n	158	13	most	most	RBS
cord-005081-kxrzv16n	158	14	important	important	JJ
cord-005081-kxrzv16n	158	15	for	for	IN
cord-005081-kxrzv16n	158	16	realizing	realize	VBG
cord-005081-kxrzv16n	158	17	a	a	DT
cord-005081-kxrzv16n	158	18	technological	technological	JJ
cord-005081-kxrzv16n	158	19	breakthrough	breakthrough	NN
cord-005081-kxrzv16n	158	20	in	in	IN
cord-005081-kxrzv16n	158	21	the	the	DT
cord-005081-kxrzv16n	158	22	mass	mass	NN
cord-005081-kxrzv16n	158	23	production	production	NN
cord-005081-kxrzv16n	158	24	of	of	IN
cord-005081-kxrzv16n	158	25	safe	safe	JJ
cord-005081-kxrzv16n	158	26	influenza	influenza	NN
cord-005081-kxrzv16n	158	27	vaccines	vaccine	NNS
cord-005081-kxrzv16n	158	28	.	.	.
cord-005081-kxrzv16n	159	1	Use	use	NN
cord-005081-kxrzv16n	159	2	of	of	IN
cord-005081-kxrzv16n	159	3	vectors	vector	NNS
cord-005081-kxrzv16n	159	4	for	for	IN
cord-005081-kxrzv16n	159	5	constructing	construct	VBG
cord-005081-kxrzv16n	159	6	and	and	CC
cord-005081-kxrzv16n	159	7	producing	produce	VBG
cord-005081-kxrzv16n	159	8	virus	virus	NN
cord-005081-kxrzv16n	159	9	like	like	IN
cord-005081-kxrzv16n	159	10	particles	particle	NNS
cord-005081-kxrzv16n	159	11	as	as	IN
cord-005081-kxrzv16n	159	12	influenza	influenza	NN
cord-005081-kxrzv16n	159	13	vaccines	vaccine	NNS
cord-005081-kxrzv16n	159	14	.	.	.
cord-005081-kxrzv16n	160	1	Adenoviruses	adenovirus	NNS
cord-005081-kxrzv16n	160	2	have	have	VBP
cord-005081-kxrzv16n	160	3	been	be	VBN
cord-005081-kxrzv16n	160	4	used	use	VBN
cord-005081-kxrzv16n	160	5	as	as	IN
cord-005081-kxrzv16n	160	6	a	a	DT
cord-005081-kxrzv16n	160	7	tool	tool	NN
cord-005081-kxrzv16n	160	8	in	in	IN
cord-005081-kxrzv16n	160	9	model	model	NN
cord-005081-kxrzv16n	160	10	studies	study	NNS
cord-005081-kxrzv16n	160	11	on	on	IN
cord-005081-kxrzv16n	160	12	gene	gene	NN
cord-005081-kxrzv16n	160	13	therapy	therapy	NN
cord-005081-kxrzv16n	160	14	for	for	IN
cord-005081-kxrzv16n	160	15	many	many	JJ
cord-005081-kxrzv16n	160	16	years	year	NNS
cord-005081-kxrzv16n	160	17	.	.	.
cord-005081-kxrzv16n	161	1	In	in	IN
cord-005081-kxrzv16n	161	2	recent	recent	JJ
cord-005081-kxrzv16n	161	3	years	year	NNS
cord-005081-kxrzv16n	161	4	,	,	,
cord-005081-kxrzv16n	161	5	specialists	specialist	NNS
cord-005081-kxrzv16n	161	6	engaged	engage	VBD
cord-005081-kxrzv16n	161	7	in	in	IN
cord-005081-kxrzv16n	161	8	constructing	construct	VBG
cord-005081-kxrzv16n	161	9	recombinant	recombinant	JJ
cord-005081-kxrzv16n	161	10	vaccines	vaccine	NNS
cord-005081-kxrzv16n	161	11	have	have	VBP
cord-005081-kxrzv16n	161	12	become	become	VBN
cord-005081-kxrzv16n	161	13	interested	interested	JJ
cord-005081-kxrzv16n	161	14	in	in	IN
cord-005081-kxrzv16n	161	15	the	the	DT
cord-005081-kxrzv16n	161	16	advantages	advantage	NNS
cord-005081-kxrzv16n	161	17	promised	promise	VBN
cord-005081-kxrzv16n	161	18	by	by	IN
cord-005081-kxrzv16n	161	19	adenovirus	adenovirus	NN
cord-005081-kxrzv16n	161	20	based	base	VBN
cord-005081-kxrzv16n	161	21	vectors	vector	NNS
cord-005081-kxrzv16n	161	22	.	.	.
cord-005081-kxrzv16n	162	1	A	a	DT
cord-005081-kxrzv16n	162	2	particularly	particularly	RB
cord-005081-kxrzv16n	162	3	attractive	attractive	JJ
cord-005081-kxrzv16n	162	4	feature	feature	NN
cord-005081-kxrzv16n	162	5	of	of	IN
cord-005081-kxrzv16n	162	6	ade	ade	NNP
cord-005081-kxrzv16n	162	7	noviruses	noviruses	NNP
cord-005081-kxrzv16n	162	8	is	be	VBZ
cord-005081-kxrzv16n	162	9	their	-PRON-	PRP$
cord-005081-kxrzv16n	162	10	high	high	JJ
cord-005081-kxrzv16n	162	11	productivity	productivity	NN
cord-005081-kxrzv16n	162	12	and	and	CC
cord-005081-kxrzv16n	162	13	efficiency	efficiency	NN
cord-005081-kxrzv16n	162	14	in	in	IN
cord-005081-kxrzv16n	162	15	gene	gene	NN
cord-005081-kxrzv16n	162	16	transfer	transfer	NN
cord-005081-kxrzv16n	162	17	and	and	CC
cord-005081-kxrzv16n	162	18	expression	expression	NN
cord-005081-kxrzv16n	162	19	.	.	.
cord-005081-kxrzv16n	163	1	Vectors	vector	NNS
cord-005081-kxrzv16n	163	2	for	for	IN
cord-005081-kxrzv16n	163	3	vaccines	vaccine	NNS
cord-005081-kxrzv16n	163	4	are	be	VBP
cord-005081-kxrzv16n	163	5	constructed	construct	VBN
cord-005081-kxrzv16n	163	6	with	with	IN
cord-005081-kxrzv16n	163	7	deletions	deletion	NNS
cord-005081-kxrzv16n	163	8	by	by	IN
cord-005081-kxrzv16n	163	9	early	early	JJ
cord-005081-kxrzv16n	163	10	genes	gene	NNS
cord-005081-kxrzv16n	163	11	E1	e1	NN
cord-005081-kxrzv16n	163	12	and	and	CC
cord-005081-kxrzv16n	163	13	E2	E2	NNP
cord-005081-kxrzv16n	163	14	.	.	.
cord-005081-kxrzv16n	164	1	In	in	IN
cord-005081-kxrzv16n	164	2	some	some	DT
cord-005081-kxrzv16n	164	3	research	research	NN
cord-005081-kxrzv16n	164	4	works	work	VBZ
cord-005081-kxrzv16n	164	5	,	,	,
cord-005081-kxrzv16n	164	6	adenovirus	adenovirus	NN
cord-005081-kxrzv16n	164	7	vectors	vector	NNS
cord-005081-kxrzv16n	164	8	are	be	VBP
cord-005081-kxrzv16n	164	9	used	use	VBN
cord-005081-kxrzv16n	164	10	for	for	IN
cord-005081-kxrzv16n	164	11	the	the	DT
cord-005081-kxrzv16n	164	12	expression	expression	NN
cord-005081-kxrzv16n	164	13	of	of	IN
cord-005081-kxrzv16n	164	14	individual	individual	JJ
cord-005081-kxrzv16n	164	15	viral	viral	JJ
cord-005081-kxrzv16n	164	16	antigens	antigen	NNS
cord-005081-kxrzv16n	164	17	and	and	CC
cord-005081-kxrzv16n	164	18	,	,	,
cord-005081-kxrzv16n	164	19	in	in	IN
cord-005081-kxrzv16n	164	20	particular	particular	JJ
cord-005081-kxrzv16n	164	21	,	,	,
cord-005081-kxrzv16n	164	22	HA	HA	NNP
cord-005081-kxrzv16n	164	23	of	of	IN
cord-005081-kxrzv16n	164	24	influenza	influenza	NN
cord-005081-kxrzv16n	164	25	viruses	virus	NNS
cord-005081-kxrzv16n	164	26	.	.	.
cord-005081-kxrzv16n	165	1	A	a	DT
cord-005081-kxrzv16n	165	2	serious	serious	JJ
cord-005081-kxrzv16n	165	3	disadvantage	disadvantage	NN
cord-005081-kxrzv16n	165	4	for	for	IN
cord-005081-kxrzv16n	165	5	these	these	DT
cord-005081-kxrzv16n	165	6	vectors	vector	NNS
cord-005081-kxrzv16n	165	7	is	be	VBZ
cord-005081-kxrzv16n	165	8	the	the	DT
cord-005081-kxrzv16n	165	9	presence	presence	NN
cord-005081-kxrzv16n	165	10	in	in	IN
cord-005081-kxrzv16n	165	11	the	the	DT
cord-005081-kxrzv16n	165	12	human	human	JJ
cord-005081-kxrzv16n	165	13	population	population	NN
cord-005081-kxrzv16n	165	14	of	of	IN
cord-005081-kxrzv16n	165	15	widespread	widespread	JJ
cord-005081-kxrzv16n	165	16	immunity	immunity	NN
cord-005081-kxrzv16n	165	17	,	,	,
cord-005081-kxrzv16n	165	18	which	which	WDT
cord-005081-kxrzv16n	165	19	leads	lead	VBZ
cord-005081-kxrzv16n	165	20	to	to	IN
cord-005081-kxrzv16n	165	21	a	a	DT
cord-005081-kxrzv16n	165	22	rapid	rapid	JJ
cord-005081-kxrzv16n	165	23	limitation	limitation	NN
cord-005081-kxrzv16n	165	24	in	in	IN
cord-005081-kxrzv16n	165	25	the	the	DT
cord-005081-kxrzv16n	165	26	expression	expression	NN
cord-005081-kxrzv16n	165	27	of	of	IN
cord-005081-kxrzv16n	165	28	target	target	NN
cord-005081-kxrzv16n	165	29	antigens	antigen	NNS
cord-005081-kxrzv16n	165	30	.	.	.
cord-005081-kxrzv16n	166	1	During	during	IN
cord-005081-kxrzv16n	166	2	epidemics	epidemic	NNS
cord-005081-kxrzv16n	166	3	,	,	,
cord-005081-kxrzv16n	166	4	15	15	CD
cord-005081-kxrzv16n	166	5	-	-	SYM
cord-005081-kxrzv16n	166	6	25	25	CD
cord-005081-kxrzv16n	166	7	%	%	NN
cord-005081-kxrzv16n	166	8	of	of	IN
cord-005081-kxrzv16n	166	9	the	the	DT
cord-005081-kxrzv16n	166	10	human	human	JJ
cord-005081-kxrzv16n	166	11	population	population	NN
cord-005081-kxrzv16n	166	12	suffers	suffer	VBZ
cord-005081-kxrzv16n	166	13	from	from	IN
cord-005081-kxrzv16n	166	14	adenoviral	adenoviral	JJ
cord-005081-kxrzv16n	166	15	infections	infection	NNS
cord-005081-kxrzv16n	166	16	.	.	.
cord-005081-kxrzv16n	167	1	Hexon	Hexon	NNP
cord-005081-kxrzv16n	167	2	is	be	VBZ
cord-005081-kxrzv16n	167	3	the	the	DT
cord-005081-kxrzv16n	167	4	strongest	strong	JJS
cord-005081-kxrzv16n	167	5	antigen	antigen	NN
cord-005081-kxrzv16n	167	6	among	among	IN
cord-005081-kxrzv16n	167	7	adenoviral	adenoviral	JJ
cord-005081-kxrzv16n	167	8	proteins	protein	NNS
cord-005081-kxrzv16n	167	9	.	.	.
cord-005081-kxrzv16n	168	1	Antibodies	antibody	NNS
cord-005081-kxrzv16n	168	2	to	to	IN
cord-005081-kxrzv16n	168	3	this	this	DT
cord-005081-kxrzv16n	168	4	protein	protein	NN
cord-005081-kxrzv16n	168	5	are	be	VBP
cord-005081-kxrzv16n	168	6	recorded	record	VBN
cord-005081-kxrzv16n	168	7	in	in	IN
cord-005081-kxrzv16n	168	8	more	more	JJR
cord-005081-kxrzv16n	168	9	than	than	IN
cord-005081-kxrzv16n	168	10	75	75	CD
cord-005081-kxrzv16n	168	11	%	%	NN
cord-005081-kxrzv16n	168	12	of	of	IN
cord-005081-kxrzv16n	168	13	healthy	healthy	JJ
cord-005081-kxrzv16n	168	14	subjects	subject	NNS
cord-005081-kxrzv16n	168	15	.	.	.
cord-005081-kxrzv16n	169	1	Therefore	therefore	RB
cord-005081-kxrzv16n	169	2	,	,	,
cord-005081-kxrzv16n	169	3	when	when	WRB
cord-005081-kxrzv16n	169	4	planning	plan	VBG
cord-005081-kxrzv16n	169	5	the	the	DT
cord-005081-kxrzv16n	169	6	use	use	NN
cord-005081-kxrzv16n	169	7	of	of	IN
cord-005081-kxrzv16n	169	8	these	these	DT
cord-005081-kxrzv16n	169	9	vectors	vector	NNS
cord-005081-kxrzv16n	169	10	for	for	IN
cord-005081-kxrzv16n	169	11	some	some	DT
cord-005081-kxrzv16n	169	12	works	work	NNS
cord-005081-kxrzv16n	169	13	one	one	PRP
cord-005081-kxrzv16n	169	14	should	should	MD
cord-005081-kxrzv16n	169	15	consider	consider	VB
cord-005081-kxrzv16n	169	16	,	,	,
cord-005081-kxrzv16n	169	17	first	first	RB
cord-005081-kxrzv16n	169	18	of	of	IN
cord-005081-kxrzv16n	169	19	all	all	DT
cord-005081-kxrzv16n	169	20	,	,	,
cord-005081-kxrzv16n	169	21	their	-PRON-	PRP$
cord-005081-kxrzv16n	169	22	population	population	NN
cord-005081-kxrzv16n	169	23	receptiv	receptiv	NN
cord-005081-kxrzv16n	169	24	ity	ity	NN
cord-005081-kxrzv16n	169	25	.	.	.
cord-005081-kxrzv16n	170	1	It	-PRON-	PRP
cord-005081-kxrzv16n	170	2	equally	equally	RB
cord-005081-kxrzv16n	170	3	refers	refer	VBZ
cord-005081-kxrzv16n	170	4	to	to	IN
cord-005081-kxrzv16n	170	5	gene	gene	NN
cord-005081-kxrzv16n	170	6	therapy	therapy	NN
cord-005081-kxrzv16n	170	7	and	and	CC
cord-005081-kxrzv16n	170	8	recombinant	recombinant	JJ
cord-005081-kxrzv16n	170	9	vaccines	vaccine	NNS
cord-005081-kxrzv16n	170	10	intended	intend	VBN
cord-005081-kxrzv16n	170	11	for	for	IN
cord-005081-kxrzv16n	170	12	a	a	DT
cord-005081-kxrzv16n	170	13	wide	wide	JJ
cord-005081-kxrzv16n	170	14	application	application	NN
cord-005081-kxrzv16n	170	15	against	against	IN
cord-005081-kxrzv16n	170	16	mass	mass	JJ
cord-005081-kxrzv16n	170	17	infections	infection	NNS
cord-005081-kxrzv16n	170	18	,	,	,
cord-005081-kxrzv16n	170	19	such	such	JJ
cord-005081-kxrzv16n	170	20	as	as	IN
cord-005081-kxrzv16n	170	21	influenza	influenza	NN
cord-005081-kxrzv16n	170	22	.	.	.
cord-005081-kxrzv16n	171	1	One	one	CD
cord-005081-kxrzv16n	171	2	of	of	IN
cord-005081-kxrzv16n	171	3	the	the	DT
cord-005081-kxrzv16n	171	4	projects	project	NNS
cord-005081-kxrzv16n	171	5	of	of	IN
cord-005081-kxrzv16n	171	6	the	the	DT
cord-005081-kxrzv16n	171	7	Russian	Russian	NNP
cord-005081-kxrzv16n	171	8	Corporation	Corporation	NNP
cord-005081-kxrzv16n	171	9	of	of	IN
cord-005081-kxrzv16n	171	10	Nanotechnologies	Nanotechnologies	NNP
cord-005081-kxrzv16n	171	11	is	be	VBZ
cord-005081-kxrzv16n	171	12	devoted	devote	VBN
cord-005081-kxrzv16n	171	13	to	to	IN
cord-005081-kxrzv16n	171	14	the	the	DT
cord-005081-kxrzv16n	171	15	use	use	NN
cord-005081-kxrzv16n	171	16	of	of	IN
cord-005081-kxrzv16n	171	17	adenoviruses	adenovirus	NNS
cord-005081-kxrzv16n	171	18	as	as	IN
cord-005081-kxrzv16n	171	19	vectors	vector	NNS
cord-005081-kxrzv16n	171	20	for	for	IN
cord-005081-kxrzv16n	171	21	constructing	construct	VBG
cord-005081-kxrzv16n	171	22	influenza	influenza	NN
cord-005081-kxrzv16n	171	23	vaccines	vaccine	NNS
cord-005081-kxrzv16n	171	24	.	.	.
cord-005081-kxrzv16n	172	1	The	the	DT
cord-005081-kxrzv16n	172	2	vectors	vector	NNS
cord-005081-kxrzv16n	172	3	based	base	VBN
cord-005081-kxrzv16n	172	4	on	on	IN
cord-005081-kxrzv16n	172	5	alpha	alpha	NN
cord-005081-kxrzv16n	172	6	viruses	virus	NNS
cord-005081-kxrzv16n	172	7	are	be	VBP
cord-005081-kxrzv16n	172	8	a	a	DT
cord-005081-kxrzv16n	172	9	relatively	relatively	RB
cord-005081-kxrzv16n	172	10	new	new	JJ
cord-005081-kxrzv16n	172	11	tool	tool	NN
cord-005081-kxrzv16n	172	12	for	for	IN
cord-005081-kxrzv16n	172	13	constructing	construct	VBG
cord-005081-kxrzv16n	172	14	recombinant	recombinant	JJ
cord-005081-kxrzv16n	172	15	vaccines	vaccine	NNS
cord-005081-kxrzv16n	172	16	.	.	.
cord-005081-kxrzv16n	173	1	The	the	DT
cord-005081-kxrzv16n	173	2	Venezuelan	venezuelan	JJ
cord-005081-kxrzv16n	173	3	equine	equine	JJ
cord-005081-kxrzv16n	173	4	encephalomyelitis	encephalomyelitis	NN
cord-005081-kxrzv16n	173	5	virus	virus	NN
cord-005081-kxrzv16n	173	6	,	,	,
cord-005081-kxrzv16n	173	7	specifi	specifi	NNP
cord-005081-kxrzv16n	173	8	cally	cally	RB
cord-005081-kxrzv16n	173	9	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	173	10	for	for	IN
cord-005081-kxrzv16n	173	11	horses	horse	NNS
cord-005081-kxrzv16n	173	12	,	,	,
cord-005081-kxrzv16n	173	13	is	be	VBZ
cord-005081-kxrzv16n	173	14	especially	especially	RB
cord-005081-kxrzv16n	173	15	attractive	attractive	JJ
cord-005081-kxrzv16n	173	16	to	to	IN
cord-005081-kxrzv16n	173	17	virologists	virologist	NNS
cord-005081-kxrzv16n	173	18	as	as	IN
cord-005081-kxrzv16n	173	19	an	an	DT
cord-005081-kxrzv16n	173	20	object	object	NN
cord-005081-kxrzv16n	173	21	of	of	IN
cord-005081-kxrzv16n	173	22	research	research	NN
cord-005081-kxrzv16n	173	23	.	.	.
cord-005081-kxrzv16n	174	1	The	the	DT
cord-005081-kxrzv16n	174	2	author	author	NN
cord-005081-kxrzv16n	174	3	of	of	IN
cord-005081-kxrzv16n	174	4	this	this	DT
cord-005081-kxrzv16n	174	5	survey	survey	NN
cord-005081-kxrzv16n	174	6	studied	study	VBD
cord-005081-kxrzv16n	174	7	the	the	DT
cord-005081-kxrzv16n	174	8	basic	basic	JJ
cord-005081-kxrzv16n	174	9	problems	problem	NNS
cord-005081-kxrzv16n	174	10	of	of	IN
cord-005081-kxrzv16n	174	11	replication	replication	NN
cord-005081-kxrzv16n	174	12	and	and	CC
cord-005081-kxrzv16n	174	13	expression	expression	NN
cord-005081-kxrzv16n	174	14	of	of	IN
cord-005081-kxrzv16n	174	15	the	the	DT
cord-005081-kxrzv16n	174	16	RNA	RNA	NNP
cord-005081-kxrzv16n	174	17	containing	contain	VBG
cord-005081-kxrzv16n	174	18	virus	virus	NN
cord-005081-kxrzv16n	174	19	genome	genome	NN
cord-005081-kxrzv16n	174	20	in	in	IN
cord-005081-kxrzv16n	174	21	the	the	DT
cord-005081-kxrzv16n	174	22	early	early	JJ
cord-005081-kxrzv16n	174	23	1970s	1970	NNS
cord-005081-kxrzv16n	174	24	.	.	.
cord-005081-kxrzv16n	175	1	The	the	DT
cord-005081-kxrzv16n	175	2	expression	expression	NN
cord-005081-kxrzv16n	175	3	of	of	IN
cord-005081-kxrzv16n	175	4	this	this	DT
cord-005081-kxrzv16n	175	5	virus	virus	NN
cord-005081-kxrzv16n	175	6	genome	genome	NN
cord-005081-kxrzv16n	175	7	is	be	VBZ
cord-005081-kxrzv16n	175	8	supported	support	VBN
cord-005081-kxrzv16n	175	9	by	by	IN
cord-005081-kxrzv16n	175	10	two	two	CD
cord-005081-kxrzv16n	175	11	operons	operon	NNS
cord-005081-kxrzv16n	175	12	:	:	:
cord-005081-kxrzv16n	175	13	early	early	JJ
cord-005081-kxrzv16n	175	14	and	and	CC
cord-005081-kxrzv16n	175	15	late	late	JJ
cord-005081-kxrzv16n	175	16	genes	gene	NNS
cord-005081-kxrzv16n	175	17	.	.	.
cord-005081-kxrzv16n	176	1	For	for	IN
cord-005081-kxrzv16n	176	2	eign	eign	NNP
cord-005081-kxrzv16n	176	3	genes	gene	NNS
cord-005081-kxrzv16n	176	4	are	be	VBP
cord-005081-kxrzv16n	176	5	inserted	insert	VBN
cord-005081-kxrzv16n	176	6	in	in	IN
cord-005081-kxrzv16n	176	7	the	the	DT
cord-005081-kxrzv16n	176	8	reading	reading	NN
cord-005081-kxrzv16n	176	9	frames	frame	NNS
cord-005081-kxrzv16n	176	10	of	of	IN
cord-005081-kxrzv16n	176	11	the	the	DT
cord-005081-kxrzv16n	176	12	late	late	JJ
cord-005081-kxrzv16n	176	13	genes	gene	NNS
cord-005081-kxrzv16n	176	14	,	,	,
cord-005081-kxrzv16n	176	15	thus	thus	RB
cord-005081-kxrzv16n	176	16	providing	provide	VBG
cord-005081-kxrzv16n	176	17	a	a	DT
cord-005081-kxrzv16n	176	18	high	high	JJ
cord-005081-kxrzv16n	176	19	level	level	NN
cord-005081-kxrzv16n	176	20	of	of	IN
cord-005081-kxrzv16n	176	21	their	-PRON-	PRP$
cord-005081-kxrzv16n	176	22	expression	expression	NN
cord-005081-kxrzv16n	176	23	,	,	,
cord-005081-kxrzv16n	176	24	comparable	comparable	JJ
cord-005081-kxrzv16n	176	25	with	with	IN
cord-005081-kxrzv16n	176	26	that	that	DT
cord-005081-kxrzv16n	176	27	of	of	IN
cord-005081-kxrzv16n	176	28	the	the	DT
cord-005081-kxrzv16n	176	29	surface	surface	NN
cord-005081-kxrzv16n	176	30	major	major	JJ
cord-005081-kxrzv16n	176	31	proteins	protein	NNS
cord-005081-kxrzv16n	176	32	of	of	IN
cord-005081-kxrzv16n	176	33	alpha	alpha	NN
cord-005081-kxrzv16n	176	34	viruses	virus	NNS
cord-005081-kxrzv16n	176	35	.	.	.
cord-005081-kxrzv16n	177	1	AlphaVax	AlphaVax	NNP
cord-005081-kxrzv16n	177	2	Inc.	Inc.	NNP
cord-005081-kxrzv16n	177	3	is	be	VBZ
cord-005081-kxrzv16n	177	4	the	the	DT
cord-005081-kxrzv16n	177	5	world	world	NN
cord-005081-kxrzv16n	177	6	's	's	POS
cord-005081-kxrzv16n	177	7	leader	leader	NN
cord-005081-kxrzv16n	177	8	in	in	IN
cord-005081-kxrzv16n	177	9	using	use	VBG
cord-005081-kxrzv16n	177	10	alpha	alpha	NN
cord-005081-kxrzv16n	177	11	viruses	virus	NNS
cord-005081-kxrzv16n	177	12	as	as	IN
cord-005081-kxrzv16n	177	13	vectors	vector	NNS
cord-005081-kxrzv16n	177	14	for	for	IN
cord-005081-kxrzv16n	177	15	constructing	construct	VBG
cord-005081-kxrzv16n	177	16	vac	vac	NNP
cord-005081-kxrzv16n	177	17	cines	cines	NNP
cord-005081-kxrzv16n	177	18	.	.	.
cord-005081-kxrzv16n	178	1	At	at	IN
cord-005081-kxrzv16n	178	2	the	the	DT
cord-005081-kxrzv16n	178	3	same	same	JJ
cord-005081-kxrzv16n	178	4	time	time	NN
cord-005081-kxrzv16n	178	5	,	,	,
cord-005081-kxrzv16n	178	6	we	-PRON-	PRP
cord-005081-kxrzv16n	178	7	are	be	VBP
cord-005081-kxrzv16n	178	8	underlining	underline	VBG
cord-005081-kxrzv16n	178	9	the	the	DT
cord-005081-kxrzv16n	178	10	safety	safety	NN
cord-005081-kxrzv16n	178	11	of	of	IN
cord-005081-kxrzv16n	178	12	vectors	vector	NNS
cord-005081-kxrzv16n	178	13	based	base	VBN
cord-005081-kxrzv16n	178	14	on	on	IN
cord-005081-kxrzv16n	178	15	alpha	alpha	NN
cord-005081-kxrzv16n	178	16	viruses	virus	NNS
cord-005081-kxrzv16n	178	17	:	:	:
cord-005081-kxrzv16n	178	18	they	-PRON-	PRP
cord-005081-kxrzv16n	178	19	are	be	VBP
cord-005081-kxrzv16n	178	20	nonpatho	nonpatho	NNP
cord-005081-kxrzv16n	178	21	genic	genic	NNP
cord-005081-kxrzv16n	178	22	for	for	IN
cord-005081-kxrzv16n	178	23	humans	human	NNS
cord-005081-kxrzv16n	178	24	,	,	,
cord-005081-kxrzv16n	178	25	and	and	CC
cord-005081-kxrzv16n	178	26	the	the	DT
cord-005081-kxrzv16n	178	27	human	human	JJ
cord-005081-kxrzv16n	178	28	population	population	NN
cord-005081-kxrzv16n	178	29	has	have	VBZ
cord-005081-kxrzv16n	178	30	no	no	DT
cord-005081-kxrzv16n	178	31	immunity	immunity	NN
cord-005081-kxrzv16n	178	32	to	to	IN
cord-005081-kxrzv16n	178	33	these	these	DT
cord-005081-kxrzv16n	178	34	viruses	virus	NNS
cord-005081-kxrzv16n	178	35	,	,	,
cord-005081-kxrzv16n	178	36	since	since	IN
cord-005081-kxrzv16n	178	37	they	-PRON-	PRP
cord-005081-kxrzv16n	178	38	have	have	VBP
cord-005081-kxrzv16n	178	39	never	never	RB
cord-005081-kxrzv16n	178	40	circu	circu	JJ
cord-005081-kxrzv16n	178	41	lated	late	VBN
cord-005081-kxrzv16n	178	42	among	among	IN
cord-005081-kxrzv16n	178	43	people	people	NNS
cord-005081-kxrzv16n	178	44	.	.	.
cord-005081-kxrzv16n	179	1	Constructing	construct	VBG
cord-005081-kxrzv16n	179	2	recombinant	recombinant	JJ
cord-005081-kxrzv16n	179	3	vector	vector	NN
cord-005081-kxrzv16n	179	4	influenza	influenza	NN
cord-005081-kxrzv16n	179	5	vaccines	vaccine	NNS
cord-005081-kxrzv16n	179	6	based	base	VBN
cord-005081-kxrzv16n	179	7	on	on	IN
cord-005081-kxrzv16n	179	8	alpha	alpha	NN
cord-005081-kxrzv16n	179	9	viruses	virus	NNS
cord-005081-kxrzv16n	179	10	is	be	VBZ
cord-005081-kxrzv16n	179	11	one	one	CD
cord-005081-kxrzv16n	179	12	of	of	IN
cord-005081-kxrzv16n	179	13	the	the	DT
cord-005081-kxrzv16n	179	14	independent	independent	JJ
cord-005081-kxrzv16n	179	15	and	and	CC
cord-005081-kxrzv16n	179	16	promising	promising	JJ
cord-005081-kxrzv16n	179	17	strategies	strategy	NNS
cord-005081-kxrzv16n	179	18	in	in	IN
cord-005081-kxrzv16n	179	19	this	this	DT
cord-005081-kxrzv16n	179	20	field	field	NN
cord-005081-kxrzv16n	179	21	.	.	.
cord-005081-kxrzv16n	180	1	The	the	DT
cord-005081-kxrzv16n	180	2	project	project	NN
cord-005081-kxrzv16n	180	3	offered	offer	VBN
cord-005081-kxrzv16n	180	4	by	by	IN
cord-005081-kxrzv16n	180	5	Novavax	Novavax	NNP
cord-005081-kxrzv16n	180	6	Inc.	Inc.	NNP
cord-005081-kxrzv16n	180	7	and	and	CC
cord-005081-kxrzv16n	180	8	Protein	Protein	NNP
cord-005081-kxrzv16n	180	9	Science	Science	NNP
cord-005081-kxrzv16n	180	10	Inc.	Inc.	NNP
cord-005081-kxrzv16n	180	11	is	be	VBZ
cord-005081-kxrzv16n	180	12	one	one	CD
cord-005081-kxrzv16n	180	13	of	of	IN
cord-005081-kxrzv16n	180	14	the	the	DT
cord-005081-kxrzv16n	180	15	most	most	RBS
cord-005081-kxrzv16n	180	16	prospective	prospective	JJ
cord-005081-kxrzv16n	180	17	for	for	IN
cord-005081-kxrzv16n	180	18	constructing	construct	VBG
cord-005081-kxrzv16n	180	19	a	a	DT
cord-005081-kxrzv16n	180	20	new	new	JJ
cord-005081-kxrzv16n	180	21	type	type	NN
cord-005081-kxrzv16n	180	22	influenza	influenza	NN
cord-005081-kxrzv16n	180	23	vaccines	vaccine	NNS
cord-005081-kxrzv16n	180	24	and	and	CC
cord-005081-kxrzv16n	180	25	organizing	organize	VBG
cord-005081-kxrzv16n	180	26	their	-PRON-	PRP$
cord-005081-kxrzv16n	180	27	production	production	NN
cord-005081-kxrzv16n	180	28	.	.	.
cord-005081-kxrzv16n	181	1	These	these	DT
cord-005081-kxrzv16n	181	2	companies	company	NNS
cord-005081-kxrzv16n	181	3	use	use	VBP
cord-005081-kxrzv16n	181	4	var	var	NNP
cord-005081-kxrzv16n	181	5	ious	ious	JJ
cord-005081-kxrzv16n	181	6	vectors	vector	NNS
cord-005081-kxrzv16n	181	7	for	for	IN
cord-005081-kxrzv16n	181	8	the	the	DT
cord-005081-kxrzv16n	181	9	expression	expression	NN
cord-005081-kxrzv16n	181	10	of	of	IN
cord-005081-kxrzv16n	181	11	HA	HA	NNP
cord-005081-kxrzv16n	181	12	and	and	CC
cord-005081-kxrzv16n	181	13	other	other	JJ
cord-005081-kxrzv16n	181	14	influ	influ	NNP
cord-005081-kxrzv16n	181	15	enza	enza	NNP
cord-005081-kxrzv16n	181	16	virus	virus	NN
cord-005081-kxrzv16n	181	17	proteins	protein	NNS
cord-005081-kxrzv16n	181	18	in	in	IN
cord-005081-kxrzv16n	181	19	insect	insect	NN
cord-005081-kxrzv16n	181	20	cells	cell	NNS
cord-005081-kxrzv16n	181	21	.	.	.
cord-005081-kxrzv16n	182	1	The	the	DT
cord-005081-kxrzv16n	182	2	latter	latter	JJ
cord-005081-kxrzv16n	182	3	grow	grow	VBP
cord-005081-kxrzv16n	182	4	at	at	IN
cord-005081-kxrzv16n	182	5	a	a	DT
cord-005081-kxrzv16n	182	6	temperature	temperature	NN
cord-005081-kxrzv16n	182	7	of	of	IN
cord-005081-kxrzv16n	182	8	approximately	approximately	RB
cord-005081-kxrzv16n	182	9	22	22	CD
cord-005081-kxrzv16n	182	10	°	°	NN
cord-005081-kxrzv16n	182	11	C	c	NN
cord-005081-kxrzv16n	182	12	;	;	:
cord-005081-kxrzv16n	182	13	the	the	DT
cord-005081-kxrzv16n	182	14	temperature	temperature	NN
cord-005081-kxrzv16n	182	15	regime	regime	NN
cord-005081-kxrzv16n	182	16	for	for	IN
cord-005081-kxrzv16n	182	17	their	-PRON-	PRP$
cord-005081-kxrzv16n	182	18	growth	growth	NN
cord-005081-kxrzv16n	182	19	is	be	VBZ
cord-005081-kxrzv16n	182	20	controlled	control	VBN
cord-005081-kxrzv16n	182	21	by	by	IN
cord-005081-kxrzv16n	182	22	special	special	JJ
cord-005081-kxrzv16n	182	23	equip	equip	NN
cord-005081-kxrzv16n	182	24	ment	ment	NN
cord-005081-kxrzv16n	182	25	.	.	.
cord-005081-kxrzv16n	183	1	At	at	IN
cord-005081-kxrzv16n	183	2	the	the	DT
cord-005081-kxrzv16n	183	3	same	same	JJ
cord-005081-kxrzv16n	183	4	time	time	NN
cord-005081-kxrzv16n	183	5	,	,	,
cord-005081-kxrzv16n	183	6	culturing	culture	VBG
cord-005081-kxrzv16n	183	7	insect	insect	NN
cord-005081-kxrzv16n	183	8	cells	cell	NNS
cord-005081-kxrzv16n	183	9	is	be	VBZ
cord-005081-kxrzv16n	183	10	a	a	DT
cord-005081-kxrzv16n	183	11	sim	sim	NN
cord-005081-kxrzv16n	183	12	pler	pler	NN
cord-005081-kxrzv16n	183	13	and	and	CC
cord-005081-kxrzv16n	183	14	less	less	RBR
cord-005081-kxrzv16n	183	15	expensive	expensive	JJ
cord-005081-kxrzv16n	183	16	process	process	NN
cord-005081-kxrzv16n	183	17	,	,	,
cord-005081-kxrzv16n	183	18	compared	compare	VBN
cord-005081-kxrzv16n	183	19	to	to	IN
cord-005081-kxrzv16n	183	20	the	the	DT
cord-005081-kxrzv16n	183	21	growth	growth	NN
cord-005081-kxrzv16n	183	22	of	of	IN
cord-005081-kxrzv16n	183	23	animal	animal	NN
cord-005081-kxrzv16n	183	24	or	or	CC
cord-005081-kxrzv16n	183	25	human	human	JJ
cord-005081-kxrzv16n	183	26	cells	cell	NNS
cord-005081-kxrzv16n	183	27	,	,	,
cord-005081-kxrzv16n	183	28	and	and	CC
cord-005081-kxrzv16n	183	29	,	,	,
cord-005081-kxrzv16n	183	30	at	at	IN
cord-005081-kxrzv16n	183	31	the	the	DT
cord-005081-kxrzv16n	183	32	same	same	JJ
cord-005081-kxrzv16n	183	33	time	time	NN
cord-005081-kxrzv16n	183	34	,	,	,
cord-005081-kxrzv16n	183	35	not	not	RB
cord-005081-kxrzv16n	183	36	associated	associate	VBN
cord-005081-kxrzv16n	183	37	with	with	IN
cord-005081-kxrzv16n	183	38	a	a	DT
cord-005081-kxrzv16n	183	39	risk	risk	NN
cord-005081-kxrzv16n	183	40	of	of	IN
cord-005081-kxrzv16n	183	41	malignancy	malignancy	NN
cord-005081-kxrzv16n	183	42	devel	devel	NN
cord-005081-kxrzv16n	183	43	opment	opment	NN
cord-005081-kxrzv16n	183	44	.	.	.
cord-005081-kxrzv16n	184	1	Human	human	JJ
cord-005081-kxrzv16n	184	2	safe	safe	JJ
cord-005081-kxrzv16n	184	3	vectors	vector	NNS
cord-005081-kxrzv16n	184	4	based	base	VBN
cord-005081-kxrzv16n	184	5	on	on	IN
cord-005081-kxrzv16n	184	6	baculoviruses	baculoviruse	NNS
cord-005081-kxrzv16n	184	7	are	be	VBP
cord-005081-kxrzv16n	184	8	used	use	VBN
cord-005081-kxrzv16n	184	9	to	to	TO
cord-005081-kxrzv16n	184	10	express	express	VB
cord-005081-kxrzv16n	184	11	antigens	antigen	NNS
cord-005081-kxrzv16n	184	12	and	and	CC
cord-005081-kxrzv16n	184	13	other	other	JJ
cord-005081-kxrzv16n	184	14	foreign	foreign	JJ
cord-005081-kxrzv16n	184	15	proteins	protein	NNS
cord-005081-kxrzv16n	184	16	in	in	IN
cord-005081-kxrzv16n	184	17	insect	insect	NN
cord-005081-kxrzv16n	184	18	cells	cell	NNS
cord-005081-kxrzv16n	184	19	[	[	-LRB-
cord-005081-kxrzv16n	184	20	25	25	CD
cord-005081-kxrzv16n	184	21	]	]	-RRB-
cord-005081-kxrzv16n	184	22	.	.	.
cord-005081-kxrzv16n	185	1	Baculoviruses	Baculoviruses	NNP
cord-005081-kxrzv16n	185	2	express	express	VBP
cord-005081-kxrzv16n	185	3	polyhedrin	polyhedrin	NN
cord-005081-kxrzv16n	185	4	protein	protein	NN
cord-005081-kxrzv16n	185	5	in	in	IN
cord-005081-kxrzv16n	185	6	considerable	considerable	JJ
cord-005081-kxrzv16n	185	7	amounts	amount	NNS
cord-005081-kxrzv16n	185	8	under	under	IN
cord-005081-kxrzv16n	185	9	the	the	DT
cord-005081-kxrzv16n	185	10	control	control	NN
cord-005081-kxrzv16n	185	11	of	of	IN
cord-005081-kxrzv16n	185	12	a	a	DT
cord-005081-kxrzv16n	185	13	strong	strong	JJ
cord-005081-kxrzv16n	185	14	promoter	promoter	NN
cord-005081-kxrzv16n	185	15	.	.	.
cord-005081-kxrzv16n	186	1	Thus	thus	RB
cord-005081-kxrzv16n	186	2	,	,	,
cord-005081-kxrzv16n	186	3	a	a	DT
cord-005081-kxrzv16n	186	4	polyhedrin	polyhedrin	NN
cord-005081-kxrzv16n	186	5	promoter	promoter	NN
cord-005081-kxrzv16n	186	6	is	be	VBZ
cord-005081-kxrzv16n	186	7	used	use	VBN
cord-005081-kxrzv16n	186	8	for	for	IN
cord-005081-kxrzv16n	186	9	the	the	DT
cord-005081-kxrzv16n	186	10	expression	expression	NN
cord-005081-kxrzv16n	186	11	of	of	IN
cord-005081-kxrzv16n	186	12	foreign	foreign	JJ
cord-005081-kxrzv16n	186	13	antigens	antigen	NNS
cord-005081-kxrzv16n	186	14	(	(	-LRB-
cord-005081-kxrzv16n	186	15	Fig	Fig	NNP
cord-005081-kxrzv16n	186	16	.	.	.
cord-005081-kxrzv16n	186	17	3	3	CD
cord-005081-kxrzv16n	186	18	,	,	,
cord-005081-kxrzv16n	186	19	on	on	IN
cord-005081-kxrzv16n	186	20	the	the	DT
cord-005081-kxrzv16n	186	21	colored	colored	JJ
cord-005081-kxrzv16n	186	22	insert	insert	NN
cord-005081-kxrzv16n	186	23	)	)	-RRB-
cord-005081-kxrzv16n	186	24	.	.	.
cord-005081-kxrzv16n	187	1	With	with	IN
cord-005081-kxrzv16n	187	2	the	the	DT
cord-005081-kxrzv16n	187	3	above	above	JJ
cord-005081-kxrzv16n	187	4	constructs	construct	NNS
cord-005081-kxrzv16n	187	5	,	,	,
cord-005081-kxrzv16n	187	6	a	a	DT
cord-005081-kxrzv16n	187	7	high	high	JJ
cord-005081-kxrzv16n	187	8	level	level	NN
cord-005081-kxrzv16n	187	9	of	of	IN
cord-005081-kxrzv16n	187	10	expression	expression	NN
cord-005081-kxrzv16n	187	11	is	be	VBZ
cord-005081-kxrzv16n	187	12	achieved	achieve	VBN
cord-005081-kxrzv16n	187	13	in	in	IN
cord-005081-kxrzv16n	187	14	insect	insect	NN
cord-005081-kxrzv16n	187	15	cells	cell	NNS
cord-005081-kxrzv16n	187	16	for	for	IN
cord-005081-kxrzv16n	187	17	HA	HA	NNP
cord-005081-kxrzv16n	187	18	of	of	IN
cord-005081-kxrzv16n	187	19	different	different	JJ
cord-005081-kxrzv16n	187	20	subtypes	subtype	NNS
cord-005081-kxrzv16n	187	21	.	.	.
cord-005081-kxrzv16n	188	1	At	at	IN
cord-005081-kxrzv16n	188	2	present	present	JJ
cord-005081-kxrzv16n	188	3	,	,	,
cord-005081-kxrzv16n	188	4	two	two	CD
cord-005081-kxrzv16n	188	5	approaches	approach	NNS
cord-005081-kxrzv16n	188	6	are	be	VBP
cord-005081-kxrzv16n	188	7	applied	apply	VBN
cord-005081-kxrzv16n	188	8	for	for	IN
cord-005081-kxrzv16n	188	9	mass	mass	JJ
cord-005081-kxrzv16n	188	10	production	production	NN
cord-005081-kxrzv16n	188	11	of	of	IN
cord-005081-kxrzv16n	188	12	influenza	influenza	NN
cord-005081-kxrzv16n	188	13	vaccine	vaccine	NN
cord-005081-kxrzv16n	188	14	components	component	NNS
cord-005081-kxrzv16n	188	15	.	.	.
cord-005081-kxrzv16n	189	1	One	one	CD
cord-005081-kxrzv16n	189	2	system	system	NN
cord-005081-kxrzv16n	189	3	(	(	-LRB-
cord-005081-kxrzv16n	189	4	Protein	Protein	NNP
cord-005081-kxrzv16n	189	5	Science	Science	NNP
cord-005081-kxrzv16n	189	6	)	)	-RRB-
cord-005081-kxrzv16n	189	7	synthesizes	synthesize	VBZ
cord-005081-kxrzv16n	189	8	HA	HA	NNP
cord-005081-kxrzv16n	189	9	,	,	,
cord-005081-kxrzv16n	189	10	the	the	DT
cord-005081-kxrzv16n	189	11	main	main	JJ
cord-005081-kxrzv16n	189	12	influenza	influenza	NN
cord-005081-kxrzv16n	189	13	virus	virus	NN
cord-005081-kxrzv16n	189	14	component	component	NN
cord-005081-kxrzv16n	189	15	,	,	,
cord-005081-kxrzv16n	189	16	for	for	IN
cord-005081-kxrzv16n	189	17	a	a	DT
cord-005081-kxrzv16n	189	18	vaccine	vaccine	NN
cord-005081-kxrzv16n	189	19	.	.	.
cord-005081-kxrzv16n	190	1	The	the	DT
cord-005081-kxrzv16n	190	2	other	other	JJ
cord-005081-kxrzv16n	190	3	system	system	NN
cord-005081-kxrzv16n	190	4	(	(	-LRB-
cord-005081-kxrzv16n	190	5	NovaVax	NovaVax	NNP
cord-005081-kxrzv16n	190	6	)	)	-RRB-
cord-005081-kxrzv16n	190	7	synthesizes	synthesize	VBZ
cord-005081-kxrzv16n	190	8	simultaneously	simultaneously	RB
cord-005081-kxrzv16n	190	9	three	three	CD
cord-005081-kxrzv16n	190	10	proteins	protein	NNS
cord-005081-kxrzv16n	190	11	:	:	:
cord-005081-kxrzv16n	190	12	HA	HA	NNP
cord-005081-kxrzv16n	190	13	,	,	,
cord-005081-kxrzv16n	190	14	NA	NA	NNP
cord-005081-kxrzv16n	190	15	,	,	,
cord-005081-kxrzv16n	190	16	and	and	CC
cord-005081-kxrzv16n	190	17	M1	M1	NNP
cord-005081-kxrzv16n	190	18	.	.	.
cord-005081-kxrzv16n	191	1	Synthesis	synthesis	NN
cord-005081-kxrzv16n	191	2	of	of	IN
cord-005081-kxrzv16n	191	3	individual	individual	JJ
cord-005081-kxrzv16n	191	4	HA	HA	NNP
cord-005081-kxrzv16n	191	5	allows	allow	VBZ
cord-005081-kxrzv16n	191	6	using	use	VBG
cord-005081-kxrzv16n	191	7	this	this	DT
cord-005081-kxrzv16n	191	8	antigen	antigen	NN
cord-005081-kxrzv16n	191	9	,	,	,
cord-005081-kxrzv16n	191	10	purified	purify	VBN
cord-005081-kxrzv16n	191	11	,	,	,
cord-005081-kxrzv16n	191	12	as	as	IN
cord-005081-kxrzv16n	191	13	the	the	DT
cord-005081-kxrzv16n	191	14	main	main	JJ
cord-005081-kxrzv16n	191	15	component	component	NN
cord-005081-kxrzv16n	191	16	of	of	IN
cord-005081-kxrzv16n	191	17	a	a	DT
cord-005081-kxrzv16n	191	18	vaccine	vaccine	NN
cord-005081-kxrzv16n	191	19	identical	identical	JJ
cord-005081-kxrzv16n	191	20	in	in	IN
cord-005081-kxrzv16n	191	21	its	-PRON-	PRP$
cord-005081-kxrzv16n	191	22	properties	property	NNS
cord-005081-kxrzv16n	191	23	to	to	IN
cord-005081-kxrzv16n	191	24	a	a	DT
cord-005081-kxrzv16n	191	25	subunit	subunit	JJ
cord-005081-kxrzv16n	191	26	vaccine	vaccine	NN
cord-005081-kxrzv16n	191	27	.	.	.
cord-005081-kxrzv16n	192	1	At	at	IN
cord-005081-kxrzv16n	192	2	the	the	DT
cord-005081-kxrzv16n	192	3	same	same	JJ
cord-005081-kxrzv16n	192	4	time	time	NN
cord-005081-kxrzv16n	192	5	,	,	,
cord-005081-kxrzv16n	192	6	it	-PRON-	PRP
cord-005081-kxrzv16n	192	7	remains	remain	VBZ
cord-005081-kxrzv16n	192	8	unclear	unclear	JJ
cord-005081-kxrzv16n	192	9	if	if	IN
cord-005081-kxrzv16n	192	10	the	the	DT
cord-005081-kxrzv16n	192	11	protein	protein	NN
cord-005081-kxrzv16n	192	12	folding	fold	VBG
cord-005081-kxrzv16n	192	13	with	with	IN
cord-005081-kxrzv16n	192	14	the	the	DT
cord-005081-kxrzv16n	192	15	formation	formation	NN
cord-005081-kxrzv16n	192	16	of	of	IN
cord-005081-kxrzv16n	192	17	HA	HA	NNP
cord-005081-kxrzv16n	192	18	"	"	``
cord-005081-kxrzv16n	192	19	rosettes	rosette	NNS
cord-005081-kxrzv16n	192	20	"	"	''
cord-005081-kxrzv16n	192	21	is	be	VBZ
cord-005081-kxrzv16n	192	22	used	use	VBN
cord-005081-kxrzv16n	192	23	to	to	TO
cord-005081-kxrzv16n	192	24	prepare	prepare	VB
cord-005081-kxrzv16n	192	25	the	the	DT
cord-005081-kxrzv16n	192	26	vaccine	vaccine	NN
cord-005081-kxrzv16n	192	27	,	,	,
cord-005081-kxrzv16n	192	28	which	which	WDT
cord-005081-kxrzv16n	192	29	is	be	VBZ
cord-005081-kxrzv16n	192	30	a	a	DT
cord-005081-kxrzv16n	192	31	very	very	RB
cord-005081-kxrzv16n	192	32	important	important	JJ
cord-005081-kxrzv16n	192	33	process	process	NN
cord-005081-kxrzv16n	192	34	for	for	IN
cord-005081-kxrzv16n	192	35	increasing	increase	VBG
cord-005081-kxrzv16n	192	36	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	192	37	and	and	CC
cord-005081-kxrzv16n	192	38	ensuring	ensure	VBG
cord-005081-kxrzv16n	192	39	the	the	DT
cord-005081-kxrzv16n	192	40	quality	quality	NN
cord-005081-kxrzv16n	192	41	of	of	IN
cord-005081-kxrzv16n	192	42	the	the	DT
cord-005081-kxrzv16n	192	43	immune	immune	JJ
cord-005081-kxrzv16n	192	44	response	response	NN
cord-005081-kxrzv16n	192	45	,	,	,
cord-005081-kxrzv16n	192	46	comparable	comparable	JJ
cord-005081-kxrzv16n	192	47	to	to	IN
cord-005081-kxrzv16n	192	48	the	the	DT
cord-005081-kxrzv16n	192	49	native	native	JJ
cord-005081-kxrzv16n	192	50	HA	HA	NNP
cord-005081-kxrzv16n	192	51	in	in	IN
cord-005081-kxrzv16n	192	52	the	the	DT
cord-005081-kxrzv16n	192	53	composition	composition	NN
cord-005081-kxrzv16n	192	54	of	of	IN
cord-005081-kxrzv16n	192	55	viral	viral	JJ
cord-005081-kxrzv16n	192	56	particles	particle	NNS
cord-005081-kxrzv16n	192	57	.	.	.
cord-005081-kxrzv16n	193	1	The	the	DT
cord-005081-kxrzv16n	193	2	simultaneous	simultaneous	JJ
cord-005081-kxrzv16n	193	3	expression	expression	NN
cord-005081-kxrzv16n	193	4	of	of	IN
cord-005081-kxrzv16n	193	5	viral	viral	JJ
cord-005081-kxrzv16n	193	6	proteins	protein	NNS
cord-005081-kxrzv16n	193	7	HA	HA	NNP
cord-005081-kxrzv16n	193	8	,	,	,
cord-005081-kxrzv16n	193	9	NA	NA	NNP
cord-005081-kxrzv16n	193	10	,	,	,
cord-005081-kxrzv16n	193	11	and	and	CC
cord-005081-kxrzv16n	193	12	M1	M1	NNP
cord-005081-kxrzv16n	193	13	is	be	VBZ
cord-005081-kxrzv16n	193	14	accompanied	accompany	VBN
cord-005081-kxrzv16n	193	15	by	by	IN
cord-005081-kxrzv16n	193	16	their	-PRON-	PRP$
cord-005081-kxrzv16n	193	17	self	self	NN
cord-005081-kxrzv16n	193	18	assembly	assembly	NN
cord-005081-kxrzv16n	193	19	in	in	IN
cord-005081-kxrzv16n	193	20	insect	insect	NN
cord-005081-kxrzv16n	193	21	cells	cell	NNS
cord-005081-kxrzv16n	193	22	.	.	.
cord-005081-kxrzv16n	194	1	This	this	DT
cord-005081-kxrzv16n	194	2	process	process	NN
cord-005081-kxrzv16n	194	3	results	result	VBZ
cord-005081-kxrzv16n	194	4	in	in	IN
cord-005081-kxrzv16n	194	5	the	the	DT
cord-005081-kxrzv16n	194	6	formation	formation	NN
cord-005081-kxrzv16n	194	7	of	of	IN
cord-005081-kxrzv16n	194	8	VLPs	vlp	NNS
cord-005081-kxrzv16n	194	9	having	have	VBG
cord-005081-kxrzv16n	194	10	high	high	JJ
cord-005081-kxrzv16n	194	11	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	194	12	,	,	,
cord-005081-kxrzv16n	194	13	allowing	allow	VBG
cord-005081-kxrzv16n	194	14	the	the	DT
cord-005081-kxrzv16n	194	15	antigenic	antigenic	JJ
cord-005081-kxrzv16n	194	16	burden	burden	NN
cord-005081-kxrzv16n	194	17	to	to	TO
cord-005081-kxrzv16n	194	18	be	be	VB
cord-005081-kxrzv16n	194	19	reduced	reduce	VBN
cord-005081-kxrzv16n	195	1	,	,	,
cord-005081-kxrzv16n	195	2	com	com	NN
cord-005081-kxrzv16n	195	3	pared	pare	VBN
cord-005081-kxrzv16n	195	4	to	to	IN
cord-005081-kxrzv16n	195	5	the	the	DT
cord-005081-kxrzv16n	195	6	individual	individual	JJ
cord-005081-kxrzv16n	195	7	HA	HA	NNP
cord-005081-kxrzv16n	195	8	.	.	.
cord-005081-kxrzv16n	196	1	The	the	DT
cord-005081-kxrzv16n	196	2	system	system	NN
cord-005081-kxrzv16n	196	3	of	of	IN
cord-005081-kxrzv16n	196	4	obtaining	obtain	VBG
cord-005081-kxrzv16n	196	5	VLPs	vlp	NNS
cord-005081-kxrzv16n	196	6	using	use	VBG
cord-005081-kxrzv16n	196	7	the	the	DT
cord-005081-kxrzv16n	196	8	Sf9	Sf9	NNP
cord-005081-kxrzv16n	196	9	insect	insect	NN
cord-005081-kxrzv16n	196	10	cell	cell	NN
cord-005081-kxrzv16n	196	11	line	line	NN
cord-005081-kxrzv16n	196	12	with	with	IN
cord-005081-kxrzv16n	196	13	a	a	DT
cord-005081-kxrzv16n	196	14	baculoviral	baculoviral	JJ
cord-005081-kxrzv16n	196	15	vector	vector	NN
cord-005081-kxrzv16n	196	16	expressing	express	VBG
cord-005081-kxrzv16n	196	17	three	three	CD
cord-005081-kxrzv16n	196	18	main	main	JJ
cord-005081-kxrzv16n	196	19	proteins	protein	NNS
cord-005081-kxrzv16n	196	20	HA	HA	NNP
cord-005081-kxrzv16n	196	21	,	,	,
cord-005081-kxrzv16n	196	22	NA	NA	NNP
cord-005081-kxrzv16n	196	23	,	,	,
cord-005081-kxrzv16n	196	24	and	and	CC
cord-005081-kxrzv16n	196	25	M1	M1	NNP
cord-005081-kxrzv16n	196	26	(	(	-LRB-
cord-005081-kxrzv16n	196	27	see	see	VB
cord-005081-kxrzv16n	196	28	Fig	Fig	NNP
cord-005081-kxrzv16n	196	29	.	.	.
cord-005081-kxrzv16n	197	1	3	3	LS
cord-005081-kxrzv16n	197	2	)	)	-RRB-
cord-005081-kxrzv16n	197	3	was	be	VBD
cord-005081-kxrzv16n	197	4	tested	test	VBN
cord-005081-kxrzv16n	197	5	in	in	IN
cord-005081-kxrzv16n	197	6	the	the	DT
cord-005081-kxrzv16n	197	7	pandemic	pandemic	NN
cord-005081-kxrzv16n	197	8	H5N1	H5N1	NNP
cord-005081-kxrzv16n	197	9	and	and	CC
cord-005081-kxrzv16n	197	10	H9N2	H9N2	NNP
cord-005081-kxrzv16n	197	11	viruses	virus	NNS
cord-005081-kxrzv16n	197	12	and	and	CC
cord-005081-kxrzv16n	197	13	the	the	DT
cord-005081-kxrzv16n	197	14	sea	sea	NN
cord-005081-kxrzv16n	197	15	sonal	sonal	JJ
cord-005081-kxrzv16n	197	16	influenza	influenza	NN
cord-005081-kxrzv16n	197	17	H3N2	H3N2	NNP
cord-005081-kxrzv16n	197	18	virus	virus	NN
cord-005081-kxrzv16n	197	19	.	.	.
cord-005081-kxrzv16n	198	1	In	in	IN
cord-005081-kxrzv16n	198	2	all	all	DT
cord-005081-kxrzv16n	198	3	cases	case	NNS
cord-005081-kxrzv16n	198	4	,	,	,
cord-005081-kxrzv16n	198	5	the	the	DT
cord-005081-kxrzv16n	198	6	VLPs	vlp	NNS
cord-005081-kxrzv16n	198	7	had	have	VBD
cord-005081-kxrzv16n	198	8	high	high	JJ
cord-005081-kxrzv16n	198	9	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	198	10	in	in	IN
cord-005081-kxrzv16n	198	11	conformity	conformity	NN
cord-005081-kxrzv16n	198	12	with	with	IN
cord-005081-kxrzv16n	198	13	the	the	DT
cord-005081-kxrzv16n	198	14	require	require	JJ
cord-005081-kxrzv16n	198	15	ments	ment	NNS
cord-005081-kxrzv16n	198	16	for	for	IN
cord-005081-kxrzv16n	198	17	vaccine	vaccine	NN
cord-005081-kxrzv16n	198	18	preparations	preparation	NNS
cord-005081-kxrzv16n	198	19	.	.	.
cord-005081-kxrzv16n	199	1	proteins	protein	NNS
cord-005081-kxrzv16n	199	2	.	.	.
cord-005081-kxrzv16n	200	1	For	for	IN
cord-005081-kxrzv16n	200	2	many	many	JJ
cord-005081-kxrzv16n	200	3	reasons	reason	NNS
cord-005081-kxrzv16n	200	4	,	,	,
cord-005081-kxrzv16n	200	5	including	include	VBG
cord-005081-kxrzv16n	200	6	economic	economic	JJ
cord-005081-kxrzv16n	200	7	ones	one	NNS
cord-005081-kxrzv16n	200	8	,	,	,
cord-005081-kxrzv16n	200	9	the	the	DT
cord-005081-kxrzv16n	200	10	strategy	strategy	NN
cord-005081-kxrzv16n	200	11	of	of	IN
cord-005081-kxrzv16n	200	12	using	use	VBG
cord-005081-kxrzv16n	200	13	systems	system	NNS
cord-005081-kxrzv16n	200	14	producing	produce	VBG
cord-005081-kxrzv16n	200	15	vaccine	vaccine	NN
cord-005081-kxrzv16n	200	16	com	com	NN
cord-005081-kxrzv16n	200	17	ponents	ponent	NNS
cord-005081-kxrzv16n	200	18	in	in	IN
cord-005081-kxrzv16n	200	19	plants	plant	NNS
cord-005081-kxrzv16n	200	20	is	be	VBZ
cord-005081-kxrzv16n	200	21	very	very	RB
cord-005081-kxrzv16n	200	22	attractive	attractive	JJ
cord-005081-kxrzv16n	200	23	.	.	.
cord-005081-kxrzv16n	201	1	Attempts	attempt	NNS
cord-005081-kxrzv16n	201	2	are	be	VBP
cord-005081-kxrzv16n	201	3	now	now	RB
cord-005081-kxrzv16n	201	4	being	be	VBG
cord-005081-kxrzv16n	201	5	taken	take	VBN
cord-005081-kxrzv16n	201	6	to	to	TO
cord-005081-kxrzv16n	201	7	obtain	obtain	VB
cord-005081-kxrzv16n	201	8	plant	plant	NN
cord-005081-kxrzv16n	201	9	producers	producer	NNS
cord-005081-kxrzv16n	201	10	for	for	IN
cord-005081-kxrzv16n	201	11	influenza	influenza	NN
cord-005081-kxrzv16n	201	12	virus	virus	NN
cord-005081-kxrzv16n	201	13	antigens	antigen	NNS
cord-005081-kxrzv16n	201	14	[	[	-LRB-
cord-005081-kxrzv16n	201	15	7	7	CD
cord-005081-kxrzv16n	201	16	,	,	,
cord-005081-kxrzv16n	201	17	14	14	CD
cord-005081-kxrzv16n	201	18	]	]	-RRB-
cord-005081-kxrzv16n	201	19	.	.	.
cord-005081-kxrzv16n	202	1	Russia	Russia	NNP
cord-005081-kxrzv16n	202	2	is	be	VBZ
cord-005081-kxrzv16n	202	3	conducting	conduct	VBG
cord-005081-kxrzv16n	202	4	such	such	JJ
cord-005081-kxrzv16n	202	5	stud	stud	NN
cord-005081-kxrzv16n	202	6	ies	ie	NNS
cord-005081-kxrzv16n	202	7	within	within	IN
cord-005081-kxrzv16n	202	8	a	a	DT
cord-005081-kxrzv16n	202	9	few	few	JJ
cord-005081-kxrzv16n	202	10	projects	project	NNS
cord-005081-kxrzv16n	202	11	.	.	.
cord-005081-kxrzv16n	203	1	There	there	EX
cord-005081-kxrzv16n	203	2	are	be	VBP
cord-005081-kxrzv16n	203	3	attempts	attempt	NNS
cord-005081-kxrzv16n	203	4	jointly	jointly	RB
cord-005081-kxrzv16n	204	1	It	-PRON-	PRP
cord-005081-kxrzv16n	204	2	is	be	VBZ
cord-005081-kxrzv16n	204	3	natural	natural	JJ
cord-005081-kxrzv16n	204	4	that	that	IN
cord-005081-kxrzv16n	204	5	edible	edible	JJ
cord-005081-kxrzv16n	204	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	204	7	are	be	VBP
cord-005081-kxrzv16n	204	8	important	important	JJ
cord-005081-kxrzv16n	204	9	not	not	RB
cord-005081-kxrzv16n	204	10	only	only	RB
cord-005081-kxrzv16n	204	11	for	for	IN
cord-005081-kxrzv16n	204	12	controlling	control	VBG
cord-005081-kxrzv16n	204	13	zoonozic	zoonozic	NNP
cord-005081-kxrzv16n	204	14	pools	pool	NNS
cord-005081-kxrzv16n	204	15	of	of	IN
cord-005081-kxrzv16n	204	16	viruses	virus	NNS
cord-005081-kxrzv16n	204	17	and	and	CC
cord-005081-kxrzv16n	204	18	bac	bac	NNP
cord-005081-kxrzv16n	204	19	teria	teria	NNP
cord-005081-kxrzv16n	204	20	,	,	,
cord-005081-kxrzv16n	204	21	but	but	CC
cord-005081-kxrzv16n	204	22	we	-PRON-	PRP
cord-005081-kxrzv16n	204	23	believe	believe	VBP
cord-005081-kxrzv16n	204	24	that	that	IN
cord-005081-kxrzv16n	204	25	they	-PRON-	PRP
cord-005081-kxrzv16n	204	26	are	be	VBP
cord-005081-kxrzv16n	204	27	principally	principally	RB
cord-005081-kxrzv16n	204	28	signifi	signifi	NNP
cord-005081-kxrzv16n	204	29	ca	can	MD
cord-005081-kxrzv16n	204	30	nt	not	RB
cord-005081-kxrzv16n	204	31	for	for	IN
cord-005081-kxrzv16n	204	32	early	early	JJ
cord-005081-kxrzv16n	204	33	vaccination	vaccination	NN
cord-005081-kxrzv16n	204	34	in	in	IN
cord-005081-kxrzv16n	204	35	babyhood	babyhood	NN
cord-005081-kxrzv16n	204	36	when	when	WRB
cord-005081-kxrzv16n	204	37	the	the	DT
cord-005081-kxrzv16n	204	38	immune	immune	JJ
cord-005081-kxrzv16n	204	39	system	system	NN
cord-005081-kxrzv16n	204	40	of	of	IN
cord-005081-kxrzv16n	204	41	the	the	DT
cord-005081-kxrzv16n	204	42	intestines	intestine	NNS
cord-005081-kxrzv16n	204	43	in	in	IN
cord-005081-kxrzv16n	204	44	neonatals	neonatal	NNS
cord-005081-kxrzv16n	204	45	is	be	VBZ
cord-005081-kxrzv16n	204	46	still	still	RB
cord-005081-kxrzv16n	204	47	in	in	IN
cord-005081-kxrzv16n	204	48	the	the	DT
cord-005081-kxrzv16n	204	49	process	process	NN
cord-005081-kxrzv16n	204	50	of	of	IN
cord-005081-kxrzv16n	204	51	formation	formation	NN
cord-005081-kxrzv16n	204	52	.	.	.
cord-005081-kxrzv16n	205	1	Therefore	therefore	RB
cord-005081-kxrzv16n	205	2	,	,	,
cord-005081-kxrzv16n	205	3	large	large	JJ
cord-005081-kxrzv16n	205	4	scale	scale	NN
cord-005081-kxrzv16n	205	5	works	work	VBZ
cord-005081-kxrzv16n	205	6	on	on	IN
cord-005081-kxrzv16n	205	7	obtaining	obtain	VBG
cord-005081-kxrzv16n	205	8	vaccine	vaccine	NN
cord-005081-kxrzv16n	205	9	preparations	preparation	NNS
cord-005081-kxrzv16n	205	10	based	base	VBN
cord-005081-kxrzv16n	205	11	on	on	IN
cord-005081-kxrzv16n	205	12	rice	rice	NN
cord-005081-kxrzv16n	205	13	culti	culti	JJ
cord-005081-kxrzv16n	205	14	vars	var	NNS
cord-005081-kxrzv16n	205	15	are	be	VBP
cord-005081-kxrzv16n	205	16	worthy	worthy	JJ
cord-005081-kxrzv16n	205	17	of	of	IN
cord-005081-kxrzv16n	205	18	attention	attention	NN
cord-005081-kxrzv16n	205	19	[	[	-LRB-
cord-005081-kxrzv16n	205	20	26	26	CD
cord-005081-kxrzv16n	205	21	]	]	-RRB-
cord-005081-kxrzv16n	205	22	.	.	.
cord-005081-kxrzv16n	206	1	A	a	DT
cord-005081-kxrzv16n	206	2	progress	progress	NN
cord-005081-kxrzv16n	206	3	in	in	IN
cord-005081-kxrzv16n	206	4	these	these	DT
cord-005081-kxrzv16n	206	5	studies	study	NNS
cord-005081-kxrzv16n	206	6	may	may	MD
cord-005081-kxrzv16n	206	7	principally	principally	RB
cord-005081-kxrzv16n	206	8	change	change	VB
cord-005081-kxrzv16n	206	9	our	-PRON-	PRP$
cord-005081-kxrzv16n	206	10	children	child	NNS
cord-005081-kxrzv16n	206	11	's	's	POS
cord-005081-kxrzv16n	206	12	vaccina	vaccina	NNP
cord-005081-kxrzv16n	206	13	tion	tion	NNP
cord-005081-kxrzv16n	206	14	calendar	calendar	NN
cord-005081-kxrzv16n	206	15	and	and	CC
cord-005081-kxrzv16n	206	16	make	make	VB
cord-005081-kxrzv16n	206	17	vaccination	vaccination	NN
cord-005081-kxrzv16n	206	18	in	in	IN
cord-005081-kxrzv16n	206	19	infancy	infancy	NN
cord-005081-kxrzv16n	206	20	com	com	NN
cord-005081-kxrzv16n	206	21	pletely	pletely	RB
cord-005081-kxrzv16n	206	22	safe	safe	JJ
cord-005081-kxrzv16n	206	23	.	.	.
cord-005081-kxrzv16n	207	1	Genetic	genetic	JJ
cord-005081-kxrzv16n	207	2	properties	property	NNS
cord-005081-kxrzv16n	207	3	of	of	IN
cord-005081-kxrzv16n	207	4	the	the	DT
cord-005081-kxrzv16n	207	5	influenza	influenza	NN
cord-005081-kxrzv16n	207	6	A	a	DT
cord-005081-kxrzv16n	207	7	viruses	virus	NNS
cord-005081-kxrzv16n	207	8	are	be	VBP
cord-005081-kxrzv16n	207	9	characterized	characterize	VBN
cord-005081-kxrzv16n	207	10	by	by	IN
cord-005081-kxrzv16n	207	11	extreme	extreme	JJ
cord-005081-kxrzv16n	207	12	antigenic	antigenic	JJ
cord-005081-kxrzv16n	207	13	variability	variability	NN
cord-005081-kxrzv16n	207	14	.	.	.
cord-005081-kxrzv16n	208	1	The	the	DT
cord-005081-kxrzv16n	208	2	strains	strain	NNS
cord-005081-kxrzv16n	208	3	should	should	MD
cord-005081-kxrzv16n	208	4	be	be	VB
cord-005081-kxrzv16n	208	5	constantly	constantly	RB
cord-005081-kxrzv16n	208	6	monitored	monitor	VBN
cord-005081-kxrzv16n	208	7	and	and	CC
cord-005081-kxrzv16n	208	8	studied	study	VBN
cord-005081-kxrzv16n	208	9	as	as	IN
cord-005081-kxrzv16n	208	10	to	to	IN
cord-005081-kxrzv16n	208	11	their	-PRON-	PRP$
cord-005081-kxrzv16n	208	12	genetic	genetic	JJ
cord-005081-kxrzv16n	208	13	structure	structure	NN
cord-005081-kxrzv16n	208	14	and	and	CC
cord-005081-kxrzv16n	208	15	antigenic	antigenic	JJ
cord-005081-kxrzv16n	208	16	properties	property	NNS
cord-005081-kxrzv16n	208	17	.	.	.
cord-005081-kxrzv16n	209	1	A	a	DT
cord-005081-kxrzv16n	209	2	special	special	JJ
cord-005081-kxrzv16n	209	3	commission	commission	NN
cord-005081-kxrzv16n	209	4	of	of	IN
cord-005081-kxrzv16n	209	5	WHO	who	WP
cord-005081-kxrzv16n	209	6	considers	consider	VBZ
cord-005081-kxrzv16n	209	7	,	,	,
cord-005081-kxrzv16n	209	8	on	on	IN
cord-005081-kxrzv16n	209	9	an	an	DT
cord-005081-kxrzv16n	209	10	annual	annual	JJ
cord-005081-kxrzv16n	209	11	basis	basis	NN
cord-005081-kxrzv16n	209	12	,	,	,
cord-005081-kxrzv16n	209	13	data	datum	NNS
cord-005081-kxrzv16n	209	14	on	on	IN
cord-005081-kxrzv16n	209	15	the	the	DT
cord-005081-kxrzv16n	209	16	properties	property	NNS
cord-005081-kxrzv16n	209	17	of	of	IN
cord-005081-kxrzv16n	209	18	isolates	isolate	NNS
cord-005081-kxrzv16n	209	19	from	from	IN
cord-005081-kxrzv16n	209	20	all	all	RB
cord-005081-kxrzv16n	209	21	over	over	IN
cord-005081-kxrzv16n	209	22	the	the	DT
cord-005081-kxrzv16n	209	23	world	world	NN
cord-005081-kxrzv16n	209	24	and	and	CC
cord-005081-kxrzv16n	209	25	makes	make	VBZ
cord-005081-kxrzv16n	209	26	decisions	decision	NNS
cord-005081-kxrzv16n	209	27	on	on	IN
cord-005081-kxrzv16n	209	28	the	the	DT
cord-005081-kxrzv16n	209	29	strains	strain	NNS
cord-005081-kxrzv16n	209	30	in	in	IN
cord-005081-kxrzv16n	209	31	the	the	DT
cord-005081-kxrzv16n	209	32	composition	composition	NN
cord-005081-kxrzv16n	209	33	of	of	IN
cord-005081-kxrzv16n	209	34	a	a	DT
cord-005081-kxrzv16n	209	35	next	next	JJ
cord-005081-kxrzv16n	209	36	vaccine	vaccine	NN
cord-005081-kxrzv16n	209	37	.	.	.
cord-005081-kxrzv16n	210	1	At	at	IN
cord-005081-kxrzv16n	210	2	the	the	DT
cord-005081-kxrzv16n	210	3	same	same	JJ
cord-005081-kxrzv16n	210	4	time	time	NN
cord-005081-kxrzv16n	210	5	,	,	,
cord-005081-kxrzv16n	210	6	an	an	DT
cord-005081-kxrzv16n	210	7	outbreak	outbreak	NN
cord-005081-kxrzv16n	210	8	of	of	IN
cord-005081-kxrzv16n	210	9	a	a	DT
cord-005081-kxrzv16n	210	10	pandemic	pandemic	NN
cord-005081-kxrzv16n	210	11	brings	bring	VBZ
cord-005081-kxrzv16n	210	12	a	a	DT
cord-005081-kxrzv16n	210	13	sharp	sharp	JJ
cord-005081-kxrzv16n	210	14	change	change	NN
cord-005081-kxrzv16n	210	15	in	in	IN
cord-005081-kxrzv16n	210	16	the	the	DT
cord-005081-kxrzv16n	210	17	agent	agent	NN
cord-005081-kxrzv16n	210	18	's	's	POS
cord-005081-kxrzv16n	210	19	antigenic	antigenic	JJ
cord-005081-kxrzv16n	210	20	structure	structure	NN
cord-005081-kxrzv16n	210	21	or	or	CC
cord-005081-kxrzv16n	210	22	antigenic	antigenic	JJ
cord-005081-kxrzv16n	210	23	shift	shift	NN
cord-005081-kxrzv16n	210	24	.	.	.
cord-005081-kxrzv16n	211	1	In	in	IN
cord-005081-kxrzv16n	211	2	2009	2009	CD
cord-005081-kxrzv16n	211	3	,	,	,
cord-005081-kxrzv16n	211	4	an	an	DT
cord-005081-kxrzv16n	211	5	antigenic	antigenic	JJ
cord-005081-kxrzv16n	211	6	shift	shift	NN
cord-005081-kxrzv16n	211	7	occurred	occur	VBD
cord-005081-kxrzv16n	211	8	within	within	IN
cord-005081-kxrzv16n	211	9	a	a	DT
cord-005081-kxrzv16n	211	10	subtype	subtype	NN
cord-005081-kxrzv16n	211	11	of	of	IN
cord-005081-kxrzv16n	211	12	H1N1	H1N1	NNP
cord-005081-kxrzv16n	211	13	,	,	,
cord-005081-kxrzv16n	211	14	and	and	CC
cord-005081-kxrzv16n	211	15	a	a	DT
cord-005081-kxrzv16n	211	16	new	new	JJ
cord-005081-kxrzv16n	211	17	swine	swine	NN
cord-005081-kxrzv16n	211	18	lineage	lineage	NN
cord-005081-kxrzv16n	211	19	virus	virus	NN
cord-005081-kxrzv16n	211	20	emerged	emerge	VBD
cord-005081-kxrzv16n	211	21	with	with	IN
cord-005081-kxrzv16n	211	22	a	a	DT
cord-005081-kxrzv16n	211	23	princi	princi	NNP
cord-005081-kxrzv16n	211	24	pally	pally	RB
cord-005081-kxrzv16n	211	25	different	different	JJ
cord-005081-kxrzv16n	211	26	structure	structure	NN
cord-005081-kxrzv16n	211	27	of	of	IN
cord-005081-kxrzv16n	211	28	the	the	DT
cord-005081-kxrzv16n	211	29	surface	surface	NN
cord-005081-kxrzv16n	211	30	HA	HA	NNP
cord-005081-kxrzv16n	211	31	and	and	CC
cord-005081-kxrzv16n	211	32	NA	NA	NNP
cord-005081-kxrzv16n	211	33	antigens	antigen	NNS
cord-005081-kxrzv16n	211	34	.	.	.
cord-005081-kxrzv16n	212	1	The	the	DT
cord-005081-kxrzv16n	212	2	global	global	JJ
cord-005081-kxrzv16n	212	3	population	population	NN
cord-005081-kxrzv16n	212	4	in	in	IN
cord-005081-kxrzv16n	212	5	its	-PRON-	PRP$
cord-005081-kxrzv16n	212	6	majority	majority	NN
cord-005081-kxrzv16n	212	7	proved	prove	VBD
cord-005081-kxrzv16n	212	8	unprotected	unprotected	JJ
cord-005081-kxrzv16n	212	9	against	against	IN
cord-005081-kxrzv16n	212	10	this	this	DT
cord-005081-kxrzv16n	212	11	virus	virus	NN
cord-005081-kxrzv16n	212	12	;	;	:
cord-005081-kxrzv16n	212	13	its	-PRON-	PRP$
cord-005081-kxrzv16n	212	14	relatively	relatively	RB
cord-005081-kxrzv16n	212	15	high	high	JJ
cord-005081-kxrzv16n	212	16	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	212	17	explains	explain	VBZ
cord-005081-kxrzv16n	212	18	the	the	DT
cord-005081-kxrzv16n	212	19	increased	increase	VBN
cord-005081-kxrzv16n	212	20	mortality	mortality	NN
cord-005081-kxrzv16n	212	21	from	from	IN
cord-005081-kxrzv16n	212	22	the	the	DT
cord-005081-kxrzv16n	212	23	infection	infection	NN
cord-005081-kxrzv16n	212	24	caused	cause	VBN
cord-005081-kxrzv16n	212	25	by	by	IN
cord-005081-kxrzv16n	212	26	this	this	DT
cord-005081-kxrzv16n	212	27	agent	agent	NN
cord-005081-kxrzv16n	212	28	(	(	-LRB-
cord-005081-kxrzv16n	212	29	Table	Table	NNP
cord-005081-kxrzv16n	212	30	3	3	CD
cord-005081-kxrzv16n	212	31	)	)	-RRB-
cord-005081-kxrzv16n	212	32	.	.	.
cord-005081-kxrzv16n	213	1	On	on	IN
cord-005081-kxrzv16n	213	2	the	the	DT
cord-005081-kxrzv16n	213	3	other	other	JJ
cord-005081-kxrzv16n	213	4	hand	hand	NN
cord-005081-kxrzv16n	213	5	,	,	,
cord-005081-kxrzv16n	213	6	for	for	IN
cord-005081-kxrzv16n	213	7	the	the	DT
cord-005081-kxrzv16n	213	8	majority	majority	NN
cord-005081-kxrzv16n	213	9	of	of	IN
cord-005081-kxrzv16n	213	10	other	other	JJ
cord-005081-kxrzv16n	213	11	RNA	RNA	NNP
cord-005081-kxrzv16n	213	12	containing	contain	VBG
cord-005081-kxrzv16n	213	13	viruses	virus	NNS
cord-005081-kxrzv16n	213	14	,	,	,
cord-005081-kxrzv16n	213	15	researchers	researcher	NNS
cord-005081-kxrzv16n	213	16	have	have	VBP
cord-005081-kxrzv16n	213	17	obtained	obtain	VBN
cord-005081-kxrzv16n	213	18	vaccine	vaccine	NN
cord-005081-kxrzv16n	213	19	strains	strain	NNS
cord-005081-kxrzv16n	213	20	not	not	RB
cord-005081-kxrzv16n	213	21	requiring	require	VBG
cord-005081-kxrzv16n	213	22	seasonal	seasonal	JJ
cord-005081-kxrzv16n	213	23	replacement	replacement	NN
cord-005081-kxrzv16n	213	24	.	.	.
cord-005081-kxrzv16n	214	1	In	in	IN
cord-005081-kxrzv16n	214	2	particu	particu	NNP
cord-005081-kxrzv16n	214	3	lar	lar	NNP
cord-005081-kxrzv16n	214	4	,	,	,
cord-005081-kxrzv16n	214	5	it	-PRON-	PRP
cord-005081-kxrzv16n	214	6	refers	refer	VBZ
cord-005081-kxrzv16n	214	7	to	to	IN
cord-005081-kxrzv16n	214	8	the	the	DT
cord-005081-kxrzv16n	214	9	agents	agent	NNS
cord-005081-kxrzv16n	214	10	of	of	IN
cord-005081-kxrzv16n	214	11	measles	measle	NNS
cord-005081-kxrzv16n	214	12	and	and	CC
cord-005081-kxrzv16n	214	13	poliomyelitis	poliomyelitis	NN
cord-005081-kxrzv16n	214	14	.	.	.
cord-005081-kxrzv16n	215	1	The	the	DT
cord-005081-kxrzv16n	215	2	natural	natural	JJ
cord-005081-kxrzv16n	215	3	question	question	NN
cord-005081-kxrzv16n	215	4	has	have	VBZ
cord-005081-kxrzv16n	215	5	been	be	VBN
cord-005081-kxrzv16n	215	6	raised	raise	VBN
cord-005081-kxrzv16n	215	7	for	for	IN
cord-005081-kxrzv16n	215	8	years	year	NNS
cord-005081-kxrzv16n	215	9	:	:	:
cord-005081-kxrzv16n	215	10	Is	be	VBZ
cord-005081-kxrzv16n	215	11	it	-PRON-	PRP
cord-005081-kxrzv16n	215	12	possible	possible	JJ
cord-005081-kxrzv16n	215	13	to	to	TO
cord-005081-kxrzv16n	215	14	develop	develop	VB
cord-005081-kxrzv16n	215	15	some	some	DT
cord-005081-kxrzv16n	215	16	universal	universal	JJ
cord-005081-kxrzv16n	215	17	anti	anti	JJ
cord-005081-kxrzv16n	215	18	influenza	influenza	NN
cord-005081-kxrzv16n	215	19	A	a	DT
cord-005081-kxrzv16n	215	20	vaccine	vaccine	NN
cord-005081-kxrzv16n	215	21	based	base	VBN
cord-005081-kxrzv16n	215	22	on	on	IN
cord-005081-kxrzv16n	215	23	the	the	DT
cord-005081-kxrzv16n	215	24	agent	agent	NN
cord-005081-kxrzv16n	215	25	's	's	POS
cord-005081-kxrzv16n	215	26	conservative	conservative	JJ
cord-005081-kxrzv16n	215	27	proteins	protein	NNS
cord-005081-kxrzv16n	215	28	?	?	.
cord-005081-kxrzv16n	216	1	If	if	IN
cord-005081-kxrzv16n	216	2	we	-PRON-	PRP
cord-005081-kxrzv16n	216	3	take	take	VBP
cord-005081-kxrzv16n	216	4	surface	surface	NN
cord-005081-kxrzv16n	216	5	antigens	antigen	NNS
cord-005081-kxrzv16n	216	6	,	,	,
cord-005081-kxrzv16n	216	7	only	only	RB
cord-005081-kxrzv16n	216	8	three	three	CD
cord-005081-kxrzv16n	216	9	can	can	MD
cord-005081-kxrzv16n	216	10	partici	partici	VB
cord-005081-kxrzv16n	216	11	pate	pate	NNP
cord-005081-kxrzv16n	216	12	in	in	IN
cord-005081-kxrzv16n	216	13	the	the	DT
cord-005081-kxrzv16n	216	14	selection	selection	NN
cord-005081-kxrzv16n	216	15	(	(	-LRB-
cord-005081-kxrzv16n	216	16	see	see	VB
cord-005081-kxrzv16n	216	17	above	above	RB
cord-005081-kxrzv16n	216	18	)	)	-RRB-
cord-005081-kxrzv16n	216	19	.	.	.
cord-005081-kxrzv16n	217	1	The	the	DT
cord-005081-kxrzv16n	217	2	M2	M2	NNP
cord-005081-kxrzv16n	217	3	protein	protein	NN
cord-005081-kxrzv16n	217	4	's	's	POS
cord-005081-kxrzv16n	217	5	principal	principal	JJ
cord-005081-kxrzv16n	217	6	difference	difference	NN
cord-005081-kxrzv16n	217	7	from	from	IN
cord-005081-kxrzv16n	217	8	the	the	DT
cord-005081-kxrzv16n	217	9	other	other	JJ
cord-005081-kxrzv16n	217	10	two	two	CD
cord-005081-kxrzv16n	217	11	is	be	VBZ
cord-005081-kxrzv16n	217	12	its	-PRON-	PRP$
cord-005081-kxrzv16n	217	13	high	high	JJ
cord-005081-kxrzv16n	217	14	con	con	NN
cord-005081-kxrzv16n	217	15	servatism	servatism	NN
cord-005081-kxrzv16n	217	16	admitting	admit	VBG
cord-005081-kxrzv16n	217	17	only	only	RB
cord-005081-kxrzv16n	217	18	insignificant	insignificant	JJ
cord-005081-kxrzv16n	217	19	replacements	replacement	NNS
cord-005081-kxrzv16n	217	20	in	in	IN
cord-005081-kxrzv16n	217	21	the	the	DT
cord-005081-kxrzv16n	217	22	gene	gene	NN
cord-005081-kxrzv16n	217	23	structure	structure	NN
cord-005081-kxrzv16n	217	24	.	.	.
cord-005081-kxrzv16n	218	1	The	the	DT
cord-005081-kxrzv16n	218	2	surface	surface	NN
cord-005081-kxrzv16n	218	3	of	of	IN
cord-005081-kxrzv16n	218	4	virions	virion	NNS
cord-005081-kxrzv16n	218	5	exposes	expose	VBZ
cord-005081-kxrzv16n	218	6	approximately	approximately	RB
cord-005081-kxrzv16n	218	7	20	20	CD
cord-005081-kxrzv16n	218	8	copies	copy	NNS
cord-005081-kxrzv16n	218	9	of	of	IN
cord-005081-kxrzv16n	218	10	the	the	DT
cord-005081-kxrzv16n	218	11	M2	M2	NNP
cord-005081-kxrzv16n	218	12	protein	protein	NN
cord-005081-kxrzv16n	218	13	tetramer	tetramer	NN
cord-005081-kxrzv16n	218	14	that	that	WDT
cord-005081-kxrzv16n	218	15	performs	perform	VBZ
cord-005081-kxrzv16n	218	16	the	the	DT
cord-005081-kxrzv16n	218	17	functions	function	NNS
cord-005081-kxrzv16n	218	18	of	of	IN
cord-005081-kxrzv16n	218	19	ion	ion	NN
cord-005081-kxrzv16n	218	20	channel	channel	NN
cord-005081-kxrzv16n	218	21	-	-	HYPH
cord-005081-kxrzv16n	218	22	proton	proton	NN
cord-005081-kxrzv16n	218	23	pump	pump	NN
cord-005081-kxrzv16n	218	24	.	.	.
cord-005081-kxrzv16n	219	1	The	the	DT
cord-005081-kxrzv16n	219	2	functional	functional	JJ
cord-005081-kxrzv16n	219	3	activity	activity	NN
cord-005081-kxrzv16n	219	4	of	of	IN
cord-005081-kxrzv16n	219	5	the	the	DT
cord-005081-kxrzv16n	219	6	proton	proton	NN
cord-005081-kxrzv16n	219	7	pump	pump	NN
cord-005081-kxrzv16n	219	8	is	be	VBZ
cord-005081-kxrzv16n	219	9	important	important	JJ
cord-005081-kxrzv16n	219	10	at	at	IN
cord-005081-kxrzv16n	219	11	the	the	DT
cord-005081-kxrzv16n	219	12	onset	onset	NN
cord-005081-kxrzv16n	219	13	of	of	IN
cord-005081-kxrzv16n	219	14	infection	infection	NN
cord-005081-kxrzv16n	219	15	for	for	IN
cord-005081-kxrzv16n	219	16	decapsidation	decapsidation	NN
cord-005081-kxrzv16n	219	17	of	of	IN
cord-005081-kxrzv16n	219	18	the	the	DT
cord-005081-kxrzv16n	219	19	virus	virus	NN
cord-005081-kxrzv16n	219	20	in	in	IN
cord-005081-kxrzv16n	219	21	endosomes	endosome	NNS
cord-005081-kxrzv16n	219	22	and	and	CC
cord-005081-kxrzv16n	219	23	,	,	,
cord-005081-kxrzv16n	219	24	subsequently	subsequently	RB
cord-005081-kxrzv16n	219	25	,	,	,
cord-005081-kxrzv16n	219	26	under	under	IN
cord-005081-kxrzv16n	219	27	final	final	JJ
cord-005081-kxrzv16n	219	28	phases	phase	NNS
cord-005081-kxrzv16n	219	29	for	for	IN
cord-005081-kxrzv16n	219	30	gemmation	gemmation	NN
cord-005081-kxrzv16n	219	31	and	and	CC
cord-005081-kxrzv16n	219	32	release	release	NN
cord-005081-kxrzv16n	219	33	of	of	IN
cord-005081-kxrzv16n	219	34	viral	viral	JJ
cord-005081-kxrzv16n	219	35	particles	particle	NNS
cord-005081-kxrzv16n	219	36	.	.	.
cord-005081-kxrzv16n	220	1	Thus	thus	RB
cord-005081-kxrzv16n	220	2	,	,	,
cord-005081-kxrzv16n	220	3	the	the	DT
cord-005081-kxrzv16n	220	4	M2	M2	NNP
cord-005081-kxrzv16n	220	5	protein	protein	NN
cord-005081-kxrzv16n	220	6	controls	control	VBZ
cord-005081-kxrzv16n	220	7	the	the	DT
cord-005081-kxrzv16n	220	8	process	process	NN
cord-005081-kxrzv16n	220	9	of	of	IN
cord-005081-kxrzv16n	220	10	infecting	infect	VBG
cord-005081-kxrzv16n	220	11	cells	cell	NNS
cord-005081-kxrzv16n	220	12	and	and	CC
cord-005081-kxrzv16n	220	13	propagation	propagation	NN
cord-005081-kxrzv16n	220	14	of	of	IN
cord-005081-kxrzv16n	220	15	infection	infection	NN
cord-005081-kxrzv16n	220	16	.	.	.
cord-005081-kxrzv16n	221	1	It	-PRON-	PRP
cord-005081-kxrzv16n	221	2	has	have	VBZ
cord-005081-kxrzv16n	221	3	recently	recently	RB
cord-005081-kxrzv16n	221	4	been	be	VBN
cord-005081-kxrzv16n	221	5	established	establish	VBN
cord-005081-kxrzv16n	221	6	that	that	IN
cord-005081-kxrzv16n	221	7	the	the	DT
cord-005081-kxrzv16n	221	8	sign	sign	NN
cord-005081-kxrzv16n	221	9	of	of	IN
cord-005081-kxrzv16n	221	10	contagiousness	contagiousness	NNP
cord-005081-kxrzv16n	221	11	,	,	,
cord-005081-kxrzv16n	221	12	or	or	CC
cord-005081-kxrzv16n	221	13	the	the	DT
cord-005081-kxrzv16n	221	14	virus	virus	NN
cord-005081-kxrzv16n	221	15	spreading	spread	VBG
cord-005081-kxrzv16n	221	16	speed	speed	NN
cord-005081-kxrzv16n	221	17	in	in	IN
cord-005081-kxrzv16n	221	18	human	human	NN
cord-005081-kxrzv16n	221	19	to	to	IN
cord-005081-kxrzv16n	221	20	human	human	JJ
cord-005081-kxrzv16n	221	21	transmission	transmission	NN
cord-005081-kxrzv16n	221	22	,	,	,
cord-005081-kxrzv16n	221	23	is	be	VBZ
cord-005081-kxrzv16n	221	24	associated	associate	VBN
cord-005081-kxrzv16n	221	25	with	with	IN
cord-005081-kxrzv16n	221	26	the	the	DT
cord-005081-kxrzv16n	221	27	M2	M2	NNP
cord-005081-kxrzv16n	221	28	protein	protein	NN
cord-005081-kxrzv16n	221	29	[	[	-LRB-
cord-005081-kxrzv16n	221	30	27	27	CD
cord-005081-kxrzv16n	221	31	,	,	,
cord-005081-kxrzv16n	221	32	28	28	CD
cord-005081-kxrzv16n	221	33	]	]	-RRB-
cord-005081-kxrzv16n	221	34	.	.	.
cord-005081-kxrzv16n	222	1	According	accord	VBG
cord-005081-kxrzv16n	222	2	to	to	IN
cord-005081-kxrzv16n	222	3	other	other	JJ
cord-005081-kxrzv16n	222	4	data	datum	NNS
cord-005081-kxrzv16n	222	5	,	,	,
cord-005081-kxrzv16n	222	6	the	the	DT
cord-005081-kxrzv16n	222	7	M2	M2	NNP
cord-005081-kxrzv16n	222	8	protein	protein	NN
cord-005081-kxrzv16n	222	9	is	be	VBZ
cord-005081-kxrzv16n	222	10	signifi	signifi	NNP
cord-005081-kxrzv16n	222	11	cantly	cantly	RB
cord-005081-kxrzv16n	222	12	responsible	responsible	JJ
cord-005081-kxrzv16n	222	13	for	for	IN
cord-005081-kxrzv16n	222	14	the	the	DT
cord-005081-kxrzv16n	222	15	development	development	NN
cord-005081-kxrzv16n	222	16	of	of	IN
cord-005081-kxrzv16n	222	17	oxidative	oxidative	JJ
cord-005081-kxrzv16n	222	18	stress	stress	NN
cord-005081-kxrzv16n	222	19	accompanying	accompany	VBG
cord-005081-kxrzv16n	222	20	influenza	influenza	NN
cord-005081-kxrzv16n	222	21	infections	infection	NNS
cord-005081-kxrzv16n	222	22	.	.	.
cord-005081-kxrzv16n	223	1	Therefore	therefore	RB
cord-005081-kxrzv16n	223	2	,	,	,
cord-005081-kxrzv16n	223	3	induction	induction	NN
cord-005081-kxrzv16n	223	4	of	of	IN
cord-005081-kxrzv16n	223	5	an	an	DT
cord-005081-kxrzv16n	223	6	immune	immune	JJ
cord-005081-kxrzv16n	223	7	response	response	NN
cord-005081-kxrzv16n	223	8	to	to	IN
cord-005081-kxrzv16n	223	9	this	this	DT
cord-005081-kxrzv16n	223	10	surface	surface	NN
cord-005081-kxrzv16n	223	11	pro	pro	NNP
cord-005081-kxrzv16n	223	12	tein	tein	NNP
cord-005081-kxrzv16n	223	13	is	be	VBZ
cord-005081-kxrzv16n	223	14	believed	believe	VBN
cord-005081-kxrzv16n	223	15	to	to	TO
cord-005081-kxrzv16n	223	16	be	be	VB
cord-005081-kxrzv16n	223	17	very	very	RB
cord-005081-kxrzv16n	223	18	important	important	JJ
cord-005081-kxrzv16n	223	19	for	for	IN
cord-005081-kxrzv16n	223	20	the	the	DT
cord-005081-kxrzv16n	223	21	protection	protection	NN
cord-005081-kxrzv16n	223	22	against	against	IN
cord-005081-kxrzv16n	223	23	influenza	influenza	NN
cord-005081-kxrzv16n	223	24	infections	infection	NNS
cord-005081-kxrzv16n	223	25	.	.	.
cord-005081-kxrzv16n	224	1	At	at	IN
cord-005081-kxrzv16n	224	2	present	present	NN
cord-005081-kxrzv16n	224	3	,	,	,
cord-005081-kxrzv16n	224	4	the	the	DT
cord-005081-kxrzv16n	224	5	construction	construction	NN
cord-005081-kxrzv16n	224	6	,	,	,
cord-005081-kxrzv16n	224	7	preclinical	preclinical	JJ
cord-005081-kxrzv16n	224	8	trials	trial	NNS
cord-005081-kxrzv16n	224	9	and	and	CC
cord-005081-kxrzv16n	224	10	,	,	,
cord-005081-kxrzv16n	224	11	in	in	IN
cord-005081-kxrzv16n	224	12	some	some	DT
cord-005081-kxrzv16n	224	13	cases	case	NNS
cord-005081-kxrzv16n	224	14	,	,	,
cord-005081-kxrzv16n	224	15	clinical	clinical	JJ
cord-005081-kxrzv16n	224	16	trials	trial	NNS
cord-005081-kxrzv16n	224	17	have	have	VBP
cord-005081-kxrzv16n	224	18	been	be	VBN
cord-005081-kxrzv16n	224	19	completed	complete	VBN
cord-005081-kxrzv16n	224	20	on	on	IN
cord-005081-kxrzv16n	224	21	the	the	DT
cord-005081-kxrzv16n	224	22	following	follow	VBG
cord-005081-kxrzv16n	224	23	preparations	preparation	NNS
cord-005081-kxrzv16n	224	24	:	:	:
cord-005081-kxrzv16n	224	25	(	(	-LRB-
cord-005081-kxrzv16n	224	26	1	1	LS
cord-005081-kxrzv16n	224	27	)	)	-RRB-
cord-005081-kxrzv16n	224	28	Recombinant	recombinant	JJ
cord-005081-kxrzv16n	224	29	preparation	preparation	NN
cord-005081-kxrzv16n	224	30	of	of	IN
cord-005081-kxrzv16n	224	31	the	the	DT
cord-005081-kxrzv16n	224	32	apical	apical	JJ
cord-005081-kxrzv16n	224	33	(	(	-LRB-
cord-005081-kxrzv16n	224	34	extramembraneous	extramembraneous	NNP
cord-005081-kxrzv16n	224	35	)	)	-RRB-
cord-005081-kxrzv16n	224	36	M2e	m2e	NN
cord-005081-kxrzv16n	224	37	domain	domain	NN
cord-005081-kxrzv16n	224	38	in	in	IN
cord-005081-kxrzv16n	224	39	the	the	DT
cord-005081-kxrzv16n	224	40	capsid	capsid	JJ
cord-005081-kxrzv16n	224	41	car	car	NN
cord-005081-kxrzv16n	224	42	rier	rier	NN
cord-005081-kxrzv16n	224	43	of	of	IN
cord-005081-kxrzv16n	224	44	the	the	DT
cord-005081-kxrzv16n	224	45	hepatitis	hepatitis	NN
cord-005081-kxrzv16n	224	46	B	B	NNP
cord-005081-kxrzv16n	224	47	protein	protein	NN
cord-005081-kxrzv16n	224	48	particles	particle	NNS
cord-005081-kxrzv16n	224	49	.	.	.
cord-005081-kxrzv16n	225	1	(	(	-LRB-
cord-005081-kxrzv16n	225	2	2	2	LS
cord-005081-kxrzv16n	225	3	)	)	-RRB-
cord-005081-kxrzv16n	225	4	Recombinant	recombinant	JJ
cord-005081-kxrzv16n	225	5	preparation	preparation	NN
cord-005081-kxrzv16n	225	6	,	,	,
cord-005081-kxrzv16n	225	7	including	include	VBG
cord-005081-kxrzv16n	225	8	in	in	IN
cord-005081-kxrzv16n	225	9	tan	tan	NNP
cord-005081-kxrzv16n	225	10	dem	dem	NNP
cord-005081-kxrzv16n	225	11	repetitive	repetitive	JJ
cord-005081-kxrzv16n	225	12	copies	copy	NNS
cord-005081-kxrzv16n	225	13	of	of	IN
cord-005081-kxrzv16n	225	14	24	24	CD
cord-005081-kxrzv16n	225	15	amino	amino	NN
cord-005081-kxrzv16n	225	16	acid	acid	NN
cord-005081-kxrzv16n	225	17	residues	residue	NNS
cord-005081-kxrzv16n	225	18	of	of	IN
cord-005081-kxrzv16n	225	19	the	the	DT
cord-005081-kxrzv16n	225	20	M2	M2	NNP
cord-005081-kxrzv16n	225	21	protein	protein	NN
cord-005081-kxrzv16n	225	22	in	in	IN
cord-005081-kxrzv16n	225	23	the	the	DT
cord-005081-kxrzv16n	225	24	composition	composition	NN
cord-005081-kxrzv16n	225	25	of	of	IN
cord-005081-kxrzv16n	225	26	E.	E.	NNP
cord-005081-kxrzv16n	225	27	coli	coli	NNS
cord-005081-kxrzv16n	225	28	flagellin	flagellin	NNP
cord-005081-kxrzv16n	225	29	.	.	.
cord-005081-kxrzv16n	226	1	(	(	-LRB-
cord-005081-kxrzv16n	226	2	3	3	LS
cord-005081-kxrzv16n	226	3	)	)	-RRB-
cord-005081-kxrzv16n	226	4	Recombinant	recombinant	JJ
cord-005081-kxrzv16n	226	5	fused	fuse	VBN
cord-005081-kxrzv16n	226	6	protein	protein	NN
cord-005081-kxrzv16n	226	7	M2e	m2e	NN
cord-005081-kxrzv16n	226	8	conjugated	conjugate	VBN
cord-005081-kxrzv16n	226	9	with	with	IN
cord-005081-kxrzv16n	226	10	a	a	DT
cord-005081-kxrzv16n	226	11	residue	residue	NN
cord-005081-kxrzv16n	226	12	of	of	IN
cord-005081-kxrzv16n	226	13	cysteine	cysteine	NN
cord-005081-kxrzv16n	226	14	at	at	IN
cord-005081-kxrzv16n	226	15	the	the	DT
cord-005081-kxrzv16n	226	16	3	3	CD
cord-005081-kxrzv16n	226	17	position	position	NN
cord-005081-kxrzv16n	226	18	and	and	CC
cord-005081-kxrzv16n	226	19	con	con	NN
cord-005081-kxrzv16n	226	20	taining	taine	VBG
cord-005081-kxrzv16n	226	21	palmitine	palmitine	NN
cord-005081-kxrzv16n	226	22	acid	acid	NN
cord-005081-kxrzv16n	226	23	as	as	IN
cord-005081-kxrzv16n	226	24	an	an	DT
cord-005081-kxrzv16n	226	25	adjuvant	adjuvant	NN
cord-005081-kxrzv16n	226	26	.	.	.
cord-005081-kxrzv16n	227	1	In	in	IN
cord-005081-kxrzv16n	227	2	Fig	Fig	NNP
cord-005081-kxrzv16n	227	3	.	.	.
cord-005081-kxrzv16n	227	4	4a	4a	CD
cord-005081-kxrzv16n	227	5	(	(	-LRB-
cord-005081-kxrzv16n	227	6	on	on	IN
cord-005081-kxrzv16n	227	7	the	the	DT
cord-005081-kxrzv16n	227	8	color	color	NN
cord-005081-kxrzv16n	227	9	insert	insert	NN
cord-005081-kxrzv16n	227	10	)	)	-RRB-
cord-005081-kxrzv16n	227	11	,	,	,
cord-005081-kxrzv16n	227	12	the	the	DT
cord-005081-kxrzv16n	227	13	M2	M2	NNP
cord-005081-kxrzv16n	227	14	protein	protein	NN
cord-005081-kxrzv16n	227	15	is	be	VBZ
cord-005081-kxrzv16n	227	16	represented	represent	VBN
cord-005081-kxrzv16n	227	17	by	by	IN
cord-005081-kxrzv16n	227	18	a	a	DT
cord-005081-kxrzv16n	227	19	physical	physical	JJ
cord-005081-kxrzv16n	227	20	map	map	NN
cord-005081-kxrzv16n	227	21	,	,	,
cord-005081-kxrzv16n	227	22	where	where	WRB
cord-005081-kxrzv16n	227	23	the	the	DT
cord-005081-kxrzv16n	227	24	transmem	transmem	NNP
cord-005081-kxrzv16n	227	25	braneous	braneous	NNP
cord-005081-kxrzv16n	227	26	domain	domain	NN
cord-005081-kxrzv16n	227	27	is	be	VBZ
cord-005081-kxrzv16n	227	28	underlined	underline	VBN
cord-005081-kxrzv16n	227	29	by	by	IN
cord-005081-kxrzv16n	227	30	alpha	alpha	NN
cord-005081-kxrzv16n	227	31	spiral	spiral	NN
cord-005081-kxrzv16n	227	32	(	(	-LRB-
cord-005081-kxrzv16n	227	33	given	give	VBN
cord-005081-kxrzv16n	227	34	is	be	VBZ
cord-005081-kxrzv16n	227	35	the	the	DT
cord-005081-kxrzv16n	227	36	most	most	RBS
cord-005081-kxrzv16n	227	37	spread	spread	VBN
cord-005081-kxrzv16n	227	38	sequence	sequence	NN
cord-005081-kxrzv16n	227	39	with	with	IN
cord-005081-kxrzv16n	227	40	indicating	indicate	VBG
cord-005081-kxrzv16n	227	41	amanta	amanta	NN
cord-005081-kxrzv16n	227	42	dine	dine	VB
cord-005081-kxrzv16n	227	43	and	and	CC
cord-005081-kxrzv16n	227	44	rimantadine	rimantadine	VB
cord-005081-kxrzv16n	227	45	resistant	resistant	JJ
cord-005081-kxrzv16n	227	46	mutations	mutation	NNS
cord-005081-kxrzv16n	227	47	;	;	:
cord-005081-kxrzv16n	227	48	the	the	DT
cord-005081-kxrzv16n	227	49	aman	aman	NNP
cord-005081-kxrzv16n	227	50	tadine	tadine	NNP
cord-005081-kxrzv16n	227	51	molecule	molecule	NN
cord-005081-kxrzv16n	227	52	is	be	VBZ
cord-005081-kxrzv16n	227	53	designated	designate	VBN
cord-005081-kxrzv16n	227	54	in	in	IN
cord-005081-kxrzv16n	227	55	yellow	yellow	JJ
cord-005081-kxrzv16n	227	56	in	in	IN
cord-005081-kxrzv16n	227	57	the	the	DT
cord-005081-kxrzv16n	227	58	region	region	NN
cord-005081-kxrzv16n	227	59	of	of	IN
cord-005081-kxrzv16n	227	60	adamant	adamant	JJ
cord-005081-kxrzv16n	227	61	binding	binding	NN
cord-005081-kxrzv16n	227	62	site	site	NN
cord-005081-kxrzv16n	227	63	)	)	-RRB-
cord-005081-kxrzv16n	227	64	;	;	:
cord-005081-kxrzv16n	227	65	given	give	VBN
cord-005081-kxrzv16n	227	66	on	on	IN
cord-005081-kxrzv16n	227	67	the	the	DT
cord-005081-kxrzv16n	227	68	map	map	NN
cord-005081-kxrzv16n	227	69	's	's	POS
cord-005081-kxrzv16n	227	70	left	leave	VBN
cord-005081-kxrzv16n	227	71	is	be	VBZ
cord-005081-kxrzv16n	227	72	the	the	DT
cord-005081-kxrzv16n	227	73	extramembraneous	extramembraneous	JJ
cord-005081-kxrzv16n	227	74	domain	domain	NN
cord-005081-kxrzv16n	227	75	at	at	IN
cord-005081-kxrzv16n	227	76	N	n	CD
cord-005081-kxrzv16n	227	77	end	end	NN
cord-005081-kxrzv16n	228	1	(	(	-LRB-
cord-005081-kxrzv16n	228	2	positions	position	NNS
cord-005081-kxrzv16n	228	3	1	1	CD
cord-005081-kxrzv16n	228	4	-	-	SYM
cord-005081-kxrzv16n	228	5	25	25	CD
cord-005081-kxrzv16n	228	6	)	)	-RRB-
cord-005081-kxrzv16n	228	7	,	,	,
cord-005081-kxrzv16n	228	8	the	the	DT
cord-005081-kxrzv16n	228	9	blue	blue	JJ
cord-005081-kxrzv16n	228	10	arrow	arrow	NN
cord-005081-kxrzv16n	228	11	points	point	VBZ
cord-005081-kxrzv16n	228	12	to	to	IN
cord-005081-kxrzv16n	228	13	variations	variation	NNS
cord-005081-kxrzv16n	228	14	of	of	IN
cord-005081-kxrzv16n	228	15	this	this	DT
cord-005081-kxrzv16n	228	16	domain	domain	NN
cord-005081-kxrzv16n	228	17	's	's	POS
cord-005081-kxrzv16n	228	18	sequences	sequence	NNS
cord-005081-kxrzv16n	228	19	in	in	IN
cord-005081-kxrzv16n	228	20	different	different	JJ
cord-005081-kxrzv16n	228	21	subtypes	subtype	NNS
cord-005081-kxrzv16n	228	22	of	of	IN
cord-005081-kxrzv16n	228	23	influenza	influenza	NN
cord-005081-kxrzv16n	228	24	A	a	NN
cord-005081-kxrzv16n	228	25	viruses	virus	NNS
cord-005081-kxrzv16n	228	26	(	(	-LRB-
cord-005081-kxrzv16n	228	27	see	see	VB
cord-005081-kxrzv16n	228	28	Fig	Fig	NNP
cord-005081-kxrzv16n	228	29	.	.	NNP
cord-005081-kxrzv16n	228	30	4c	4c	CD
cord-005081-kxrzv16n	228	31	)	)	-RRB-
cord-005081-kxrzv16n	228	32	.	.	.
cord-005081-kxrzv16n	229	1	On	on	IN
cord-005081-kxrzv16n	229	2	the	the	DT
cord-005081-kxrzv16n	229	3	top	top	JJ
cord-005081-kxrzv16n	229	4	right	right	NN
cord-005081-kxrzv16n	229	5	is	be	VBZ
cord-005081-kxrzv16n	229	6	a	a	DT
cord-005081-kxrzv16n	229	7	tetramer	tetramer	NN
cord-005081-kxrzv16n	229	8	model	model	NN
cord-005081-kxrzv16n	229	9	of	of	IN
cord-005081-kxrzv16n	229	10	the	the	DT
cord-005081-kxrzv16n	229	11	transmembraneous	transmembraneous	JJ
cord-005081-kxrzv16n	229	12	domain	domain	NN
cord-005081-kxrzv16n	229	13	in	in	IN
cord-005081-kxrzv16n	229	14	a	a	DT
cord-005081-kxrzv16n	229	15	lipid	lipid	NN
cord-005081-kxrzv16n	229	16	membrane	membrane	NN
cord-005081-kxrzv16n	229	17	(	(	-LRB-
cord-005081-kxrzv16n	229	18	see	see	VB
cord-005081-kxrzv16n	229	19	Fig	Fig	NNP
cord-005081-kxrzv16n	229	20	.	.	.
cord-005081-kxrzv16n	229	21	4b	4b	CD
cord-005081-kxrzv16n	229	22	)	)	-RRB-
cord-005081-kxrzv16n	229	23	.	.	.
cord-005081-kxrzv16n	230	1	Considering	consider	VBG
cord-005081-kxrzv16n	230	2	the	the	DT
cord-005081-kxrzv16n	230	3	first	first	JJ
cord-005081-kxrzv16n	230	4	importance	importance	NN
cord-005081-kxrzv16n	230	5	of	of	IN
cord-005081-kxrzv16n	230	6	projects	project	NNS
cord-005081-kxrzv16n	230	7	on	on	IN
cord-005081-kxrzv16n	230	8	cre	cre	NNP
cord-005081-kxrzv16n	230	9	ating	ate	VBG
cord-005081-kxrzv16n	230	10	a	a	DT
cord-005081-kxrzv16n	230	11	universal	universal	JJ
cord-005081-kxrzv16n	230	12	vaccine	vaccine	NN
cord-005081-kxrzv16n	230	13	,	,	,
cord-005081-kxrzv16n	230	14	we	-PRON-	PRP
cord-005081-kxrzv16n	230	15	give	give	VBP
cord-005081-kxrzv16n	230	16	below	below	IN
cord-005081-kxrzv16n	230	17	the	the	DT
cord-005081-kxrzv16n	230	18	M2	M2	NNP
cord-005081-kxrzv16n	230	19	protein	protein	NN
cord-005081-kxrzv16n	230	20	sequences	sequence	NNS
cord-005081-kxrzv16n	230	21	for	for	IN
cord-005081-kxrzv16n	230	22	important	important	JJ
cord-005081-kxrzv16n	230	23	pandemic	pandemic	NN
cord-005081-kxrzv16n	230	24	viruses	virus	NNS
cord-005081-kxrzv16n	230	25	character	character	NN
cord-005081-kxrzv16n	230	26	ized	ize	VBN
cord-005081-kxrzv16n	230	27	by	by	IN
cord-005081-kxrzv16n	230	28	a	a	DT
cord-005081-kxrzv16n	230	29	high	high	JJ
cord-005081-kxrzv16n	230	30	level	level	NN
cord-005081-kxrzv16n	230	31	of	of	IN
cord-005081-kxrzv16n	230	32	conservativeness	conservativeness	NN
cord-005081-kxrzv16n	230	33	,	,	,
cord-005081-kxrzv16n	230	34	a	a	DT
cord-005081-kxrzv16n	230	35	very	very	RB
cord-005081-kxrzv16n	230	36	valuable	valuable	JJ
cord-005081-kxrzv16n	230	37	quality	quality	NN
cord-005081-kxrzv16n	230	38	for	for	IN
cord-005081-kxrzv16n	230	39	constructing	construct	VBG
cord-005081-kxrzv16n	230	40	a	a	DT
cord-005081-kxrzv16n	230	41	universal	universal	JJ
cord-005081-kxrzv16n	230	42	vaccine	vaccine	NN
cord-005081-kxrzv16n	230	43	(	(	-LRB-
cord-005081-kxrzv16n	230	44	Fig	Fig	NNP
cord-005081-kxrzv16n	230	45	.	.	.
cord-005081-kxrzv16n	230	46	5	5	CD
cord-005081-kxrzv16n	230	47	)	)	-RRB-
cord-005081-kxrzv16n	230	48	.	.	.
cord-005081-kxrzv16n	231	1	The	the	DT
cord-005081-kxrzv16n	231	2	high	high	JJ
cord-005081-kxrzv16n	231	3	conservativeness	conservativeness	NN
cord-005081-kxrzv16n	231	4	of	of	IN
cord-005081-kxrzv16n	231	5	the	the	DT
cord-005081-kxrzv16n	231	6	main	main	JJ
cord-005081-kxrzv16n	231	7	the	the	DT
cord-005081-kxrzv16n	231	8	M2	M2	NNP
cord-005081-kxrzv16n	231	9	pro	pro	NNP
cord-005081-kxrzv16n	231	10	tein	tein	NNP
cord-005081-kxrzv16n	231	11	domains	domain	NNS
cord-005081-kxrzv16n	231	12	used	use	VBN
cord-005081-kxrzv16n	231	13	in	in	IN
cord-005081-kxrzv16n	231	14	constructing	construct	VBG
cord-005081-kxrzv16n	231	15	recombinant	recombinant	JJ
cord-005081-kxrzv16n	231	16	vac	vac	NNP
cord-005081-kxrzv16n	231	17	cines	cines	NNP
cord-005081-kxrzv16n	231	18	allows	allow	VBZ
cord-005081-kxrzv16n	231	19	us	-PRON-	PRP
cord-005081-kxrzv16n	231	20	to	to	TO
cord-005081-kxrzv16n	231	21	rely	rely	VB
cord-005081-kxrzv16n	231	22	on	on	IN
cord-005081-kxrzv16n	231	23	reaching	reach	VBG
cord-005081-kxrzv16n	231	24	a	a	DT
cord-005081-kxrzv16n	231	25	sufficient	sufficient	JJ
cord-005081-kxrzv16n	231	26	efficacy	efficacy	NN
cord-005081-kxrzv16n	231	27	of	of	IN
cord-005081-kxrzv16n	231	28	the	the	DT
cord-005081-kxrzv16n	231	29	vaccines	vaccine	NNS
cord-005081-kxrzv16n	231	30	against	against	IN
cord-005081-kxrzv16n	231	31	any	any	DT
cord-005081-kxrzv16n	231	32	possible	possible	JJ
cord-005081-kxrzv16n	231	33	pandemic	pandemic	NN
cord-005081-kxrzv16n	231	34	strain	strain	NN
cord-005081-kxrzv16n	231	35	,	,	,
cord-005081-kxrzv16n	231	36	including	include	VBG
cord-005081-kxrzv16n	231	37	avian	avian	JJ
cord-005081-kxrzv16n	231	38	flu	flu	NN
cord-005081-kxrzv16n	231	39	and	and	CC
cord-005081-kxrzv16n	231	40	swine	swine	NN
cord-005081-kxrzv16n	231	41	lineage	lineage	NN
cord-005081-kxrzv16n	231	42	H1N1	H1N1	NNP
cord-005081-kxrzv16n	231	43	influ	influ	NNP
cord-005081-kxrzv16n	231	44	enza	enza	NNP
cord-005081-kxrzv16n	231	45	.	.	.
cord-005081-kxrzv16n	232	1	This	this	DT
cord-005081-kxrzv16n	232	2	type	type	NN
cord-005081-kxrzv16n	232	3	of	of	IN
cord-005081-kxrzv16n	232	4	vaccine	vaccine	NN
cord-005081-kxrzv16n	232	5	has	have	VBZ
cord-005081-kxrzv16n	232	6	been	be	VBN
cord-005081-kxrzv16n	232	7	created	create	VBN
cord-005081-kxrzv16n	232	8	in	in	IN
cord-005081-kxrzv16n	232	9	Russia	Russia	NNP
cord-005081-kxrzv16n	232	10	on	on	IN
cord-005081-kxrzv16n	232	11	the	the	DT
cord-005081-kxrzv16n	232	12	base	base	NN
cord-005081-kxrzv16n	232	13	of	of	IN
cord-005081-kxrzv16n	232	14	the	the	DT
cord-005081-kxrzv16n	232	15	Center	Center	NNP
cord-005081-kxrzv16n	232	16	Bioengineering	Bioengineering	NNP
cord-005081-kxrzv16n	232	17	,	,	,
cord-005081-kxrzv16n	232	18	Russian	Russian	NNP
cord-005081-kxrzv16n	232	19	Academy	Academy	NNP
cord-005081-kxrzv16n	232	20	of	of	IN
cord-005081-kxrzv16n	232	21	Sciences	Sciences	NNPS
cord-005081-kxrzv16n	232	22	[	[	-LRB-
cord-005081-kxrzv16n	232	23	14	14	CD
cord-005081-kxrzv16n	232	24	]	]	-RRB-
cord-005081-kxrzv16n	232	25	.	.	.
cord-005081-kxrzv16n	233	1	VACCINES	VACCINES	NNP
cord-005081-kxrzv16n	233	2	Production	production	NN
cord-005081-kxrzv16n	233	3	of	of	IN
cord-005081-kxrzv16n	233	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	233	5	,	,	,
cord-005081-kxrzv16n	233	6	as	as	RB
cord-005081-kxrzv16n	233	7	well	well	RB
cord-005081-kxrzv16n	233	8	as	as	IN
cord-005081-kxrzv16n	233	9	other	other	JJ
cord-005081-kxrzv16n	233	10	biophar	biophar	NNP
cord-005081-kxrzv16n	233	11	maceutical	maceutical	JJ
cord-005081-kxrzv16n	233	12	processes	process	NNS
cord-005081-kxrzv16n	233	13	,	,	,
cord-005081-kxrzv16n	233	14	includes	include	VBZ
cord-005081-kxrzv16n	233	15	two	two	CD
cord-005081-kxrzv16n	233	16	main	main	JJ
cord-005081-kxrzv16n	233	17	phases	phase	NNS
cord-005081-kxrzv16n	233	18	:	:	:
cord-005081-kxrzv16n	233	19	prep	prep	NN
cord-005081-kxrzv16n	233	20	aration	aration	NN
cord-005081-kxrzv16n	233	21	and	and	CC
cord-005081-kxrzv16n	233	22	main	main	JJ
cord-005081-kxrzv16n	233	23	technological	technological	JJ
cord-005081-kxrzv16n	233	24	process	process	NN
cord-005081-kxrzv16n	233	25	.	.	.
cord-005081-kxrzv16n	234	1	The	the	DT
cord-005081-kxrzv16n	234	2	preparation	preparation	NN
cord-005081-kxrzv16n	234	3	phase	phase	NN
cord-005081-kxrzv16n	234	4	consists	consist	VBZ
cord-005081-kxrzv16n	234	5	in	in	IN
cord-005081-kxrzv16n	234	6	obtaining	obtain	VBG
cord-005081-kxrzv16n	234	7	a	a	DT
cord-005081-kxrzv16n	234	8	sow	sow	NN
cord-005081-kxrzv16n	234	9	ing	ing	DT
cord-005081-kxrzv16n	234	10	material	material	NN
cord-005081-kxrzv16n	234	11	-	-	:
cord-005081-kxrzv16n	234	12	a	a	DT
cord-005081-kxrzv16n	234	13	virus	virus	NN
cord-005081-kxrzv16n	234	14	in	in	IN
cord-005081-kxrzv16n	234	15	cell	cell	NN
cord-005081-kxrzv16n	234	16	cultures	culture	NNS
cord-005081-kxrzv16n	234	17	-	-	:
cord-005081-kxrzv16n	234	18	in	in	IN
cord-005081-kxrzv16n	234	19	a	a	DT
cord-005081-kxrzv16n	234	20	limited	limited	JJ
cord-005081-kxrzv16n	234	21	quantity	quantity	NN
cord-005081-kxrzv16n	234	22	,	,	,
cord-005081-kxrzv16n	234	23	its	-PRON-	PRP$
cord-005081-kxrzv16n	234	24	subsequent	subsequent	JJ
cord-005081-kxrzv16n	234	25	cultivation	cultivation	NN
cord-005081-kxrzv16n	234	26	inside	inside	IN
cord-005081-kxrzv16n	234	27	voluminous	voluminous	JJ
cord-005081-kxrzv16n	234	28	reactors	reactor	NNS
cord-005081-kxrzv16n	234	29	,	,	,
cord-005081-kxrzv16n	234	30	and	and	CC
cord-005081-kxrzv16n	234	31	isolation	isolation	NN
cord-005081-kxrzv16n	234	32	of	of	IN
cord-005081-kxrzv16n	234	33	the	the	DT
cord-005081-kxrzv16n	234	34	virus	virus	NN
cord-005081-kxrzv16n	234	35	from	from	IN
cord-005081-kxrzv16n	234	36	cells	cell	NNS
cord-005081-kxrzv16n	234	37	and	and	CC
cord-005081-kxrzv16n	234	38	main	main	JJ
cord-005081-kxrzv16n	234	39	cellular	cellular	JJ
cord-005081-kxrzv16n	234	40	components	component	NNS
cord-005081-kxrzv16n	234	41	.	.	.
cord-005081-kxrzv16n	235	1	As	as	IN
cord-005081-kxrzv16n	235	2	a	a	DT
cord-005081-kxrzv16n	235	3	result	result	NN
cord-005081-kxrzv16n	235	4	,	,	,
cord-005081-kxrzv16n	235	5	a	a	DT
cord-005081-kxrzv16n	235	6	raw	raw	JJ
cord-005081-kxrzv16n	235	7	suspension	suspension	NN
cord-005081-kxrzv16n	235	8	of	of	IN
cord-005081-kxrzv16n	235	9	a	a	DT
cord-005081-kxrzv16n	235	10	viable	viable	JJ
cord-005081-kxrzv16n	235	11	virus	virus	NN
cord-005081-kxrzv16n	235	12	is	be	VBZ
cord-005081-kxrzv16n	235	13	obtained	obtain	VBN
cord-005081-kxrzv16n	235	14	,	,	,
cord-005081-kxrzv16n	235	15	which	which	WDT
cord-005081-kxrzv16n	235	16	is	be	VBZ
cord-005081-kxrzv16n	235	17	subjected	subject	VBN
cord-005081-kxrzv16n	235	18	to	to	IN
cord-005081-kxrzv16n	235	19	further	further	JJ
cord-005081-kxrzv16n	235	20	purification	purification	NN
cord-005081-kxrzv16n	235	21	.	.	.
cord-005081-kxrzv16n	236	1	The	the	DT
cord-005081-kxrzv16n	236	2	main	main	JJ
cord-005081-kxrzv16n	236	3	technological	technological	JJ
cord-005081-kxrzv16n	236	4	process	process	NN
cord-005081-kxrzv16n	236	5	includes	include	VBZ
cord-005081-kxrzv16n	236	6	the	the	DT
cord-005081-kxrzv16n	236	7	follow	follow	NN
cord-005081-kxrzv16n	236	8	ing	ing	DT
cord-005081-kxrzv16n	236	9	key	key	JJ
cord-005081-kxrzv16n	236	10	phases	phase	NNS
cord-005081-kxrzv16n	236	11	of	of	IN
cord-005081-kxrzv16n	236	12	purification	purification	NN
cord-005081-kxrzv16n	236	13	of	of	IN
cord-005081-kxrzv16n	236	14	the	the	DT
cord-005081-kxrzv16n	236	15	virus	virus	NN
cord-005081-kxrzv16n	236	16	:	:	:
cord-005081-kxrzv16n	236	17	concentra	concentra	NNP
cord-005081-kxrzv16n	236	18	tion	tion	NN
cord-005081-kxrzv16n	236	19	,	,	,
cord-005081-kxrzv16n	236	20	chromatography	chromatography	NN
cord-005081-kxrzv16n	236	21	,	,	,
cord-005081-kxrzv16n	236	22	ultradiafiltration	ultradiafiltration	NN
cord-005081-kxrzv16n	236	23	,	,	,
cord-005081-kxrzv16n	236	24	isolation	isolation	NN
cord-005081-kxrzv16n	236	25	of	of	IN
cord-005081-kxrzv16n	236	26	separate	separate	JJ
cord-005081-kxrzv16n	236	27	components	component	NNS
cord-005081-kxrzv16n	236	28	(	(	-LRB-
cord-005081-kxrzv16n	236	29	for	for	IN
cord-005081-kxrzv16n	236	30	split	split	NN
cord-005081-kxrzv16n	236	31	or	or	CC
cord-005081-kxrzv16n	236	32	subunit	subunit	NN
cord-005081-kxrzv16n	236	33	vaccines	vaccine	NNS
cord-005081-kxrzv16n	236	34	)	)	-RRB-
cord-005081-kxrzv16n	236	35	,	,	,
cord-005081-kxrzv16n	236	36	mixing	mix	VBG
cord-005081-kxrzv16n	236	37	with	with	IN
cord-005081-kxrzv16n	236	38	adjuvant	adjuvant	NN
cord-005081-kxrzv16n	236	39	(	(	-LRB-
cord-005081-kxrzv16n	236	40	if	if	IN
cord-005081-kxrzv16n	236	41	the	the	DT
cord-005081-kxrzv16n	236	42	latter	latter	NN
cord-005081-kxrzv16n	236	43	is	be	VBZ
cord-005081-kxrzv16n	236	44	included	include	VBN
cord-005081-kxrzv16n	236	45	in	in	IN
cord-005081-kxrzv16n	236	46	the	the	DT
cord-005081-kxrzv16n	236	47	vaccine	vaccine	NN
cord-005081-kxrzv16n	236	48	)	)	-RRB-
cord-005081-kxrzv16n	236	49	and	and	CC
cord-005081-kxrzv16n	236	50	preparation	preparation	NN
cord-005081-kxrzv16n	236	51	of	of	IN
cord-005081-kxrzv16n	236	52	the	the	DT
cord-005081-kxrzv16n	236	53	final	final	JJ
cord-005081-kxrzv16n	236	54	product	product	NN
cord-005081-kxrzv16n	236	55	for	for	IN
cord-005081-kxrzv16n	236	56	pack	pack	NN
cord-005081-kxrzv16n	236	57	aging	aging	NN
cord-005081-kxrzv16n	236	58	.	.	.
cord-005081-kxrzv16n	237	1	Below	below	IN
cord-005081-kxrzv16n	237	2	we	-PRON-	PRP
cord-005081-kxrzv16n	237	3	are	be	VBP
cord-005081-kxrzv16n	237	4	discussing	discuss	VBG
cord-005081-kxrzv16n	237	5	the	the	DT
cord-005081-kxrzv16n	237	6	current	current	JJ
cord-005081-kxrzv16n	237	7	level	level	NN
cord-005081-kxrzv16n	237	8	and	and	CC
cord-005081-kxrzv16n	237	9	prob	prob	NN
cord-005081-kxrzv16n	237	10	lems	lem	NNS
cord-005081-kxrzv16n	237	11	in	in	IN
cord-005081-kxrzv16n	237	12	the	the	DT
cord-005081-kxrzv16n	237	13	influenza	influenza	NN
cord-005081-kxrzv16n	237	14	vaccine	vaccine	NN
cord-005081-kxrzv16n	237	15	production	production	NN
cord-005081-kxrzv16n	237	16	realization	realization	NN
cord-005081-kxrzv16n	237	17	.	.	.
cord-005081-kxrzv16n	238	1	The	the	DT
cord-005081-kxrzv16n	238	2	key	key	JJ
cord-005081-kxrzv16n	238	3	phase	phase	NN
cord-005081-kxrzv16n	238	4	of	of	IN
cord-005081-kxrzv16n	238	5	the	the	DT
cord-005081-kxrzv16n	238	6	preparatory	preparatory	JJ
cord-005081-kxrzv16n	238	7	technological	technological	JJ
cord-005081-kxrzv16n	238	8	process	process	NN
cord-005081-kxrzv16n	238	9	is	be	VBZ
cord-005081-kxrzv16n	238	10	fermentation	fermentation	NN
cord-005081-kxrzv16n	238	11	.	.	.
cord-005081-kxrzv16n	239	1	The	the	DT
cord-005081-kxrzv16n	239	2	development	development	NN
cord-005081-kxrzv16n	239	3	of	of	IN
cord-005081-kxrzv16n	239	4	wave	wave	NN
cord-005081-kxrzv16n	239	5	bioreactors	bioreactor	NNS
cord-005081-kxrzv16n	239	6	used	use	VBN
cord-005081-kxrzv16n	239	7	for	for	IN
cord-005081-kxrzv16n	239	8	fermentation	fermentation	NN
cord-005081-kxrzv16n	239	9	has	have	VBZ
cord-005081-kxrzv16n	239	10	become	become	VBN
cord-005081-kxrzv16n	239	11	a	a	DT
cord-005081-kxrzv16n	239	12	turn	turn	NN
cord-005081-kxrzv16n	239	13	ing	ing	DT
cord-005081-kxrzv16n	239	14	point	point	NN
cord-005081-kxrzv16n	239	15	in	in	IN
cord-005081-kxrzv16n	239	16	the	the	DT
cord-005081-kxrzv16n	239	17	field	field	NN
cord-005081-kxrzv16n	239	18	of	of	IN
cord-005081-kxrzv16n	239	19	cell	cell	NN
cord-005081-kxrzv16n	239	20	cultivation	cultivation	NN
cord-005081-kxrzv16n	239	21	and	and	CC
cord-005081-kxrzv16n	239	22	has	have	VBZ
cord-005081-kxrzv16n	239	23	signif	signif	NNS
cord-005081-kxrzv16n	239	24	icantly	icantly	RB
cord-005081-kxrzv16n	239	25	increased	increase	VBD
cord-005081-kxrzv16n	239	26	cell	cell	NN
cord-005081-kxrzv16n	239	27	culture	culture	NN
cord-005081-kxrzv16n	239	28	yields	yield	NNS
cord-005081-kxrzv16n	239	29	in	in	IN
cord-005081-kxrzv16n	239	30	growing	grow	VBG
cord-005081-kxrzv16n	239	31	viruses	virus	NNS
cord-005081-kxrzv16n	239	32	.	.	.
cord-005081-kxrzv16n	240	1	A	a	DT
cord-005081-kxrzv16n	240	2	majority	majority	NN
cord-005081-kxrzv16n	240	3	of	of	IN
cord-005081-kxrzv16n	240	4	companies	company	NNS
cord-005081-kxrzv16n	240	5	trading	trade	VBG
cord-005081-kxrzv16n	240	6	in	in	IN
cord-005081-kxrzv16n	240	7	modern	modern	JJ
cord-005081-kxrzv16n	240	8	techno	techno	JJ
cord-005081-kxrzv16n	240	9	logical	logical	JJ
cord-005081-kxrzv16n	240	10	equipment	equipment	NN
cord-005081-kxrzv16n	240	11	recommends	recommend	VBZ
cord-005081-kxrzv16n	240	12	this	this	DT
cord-005081-kxrzv16n	240	13	type	type	NN
cord-005081-kxrzv16n	240	14	of	of	IN
cord-005081-kxrzv16n	240	15	reactors	reactor	NNS
cord-005081-kxrzv16n	240	16	.	.	.
cord-005081-kxrzv16n	241	1	The	the	DT
cord-005081-kxrzv16n	241	2	joint	joint	JJ
cord-005081-kxrzv16n	241	3	project	project	NN
cord-005081-kxrzv16n	241	4	of	of	IN
cord-005081-kxrzv16n	241	5	the	the	DT
cord-005081-kxrzv16n	241	6	Research	Research	NNP
cord-005081-kxrzv16n	241	7	Institute	Institute	NNP
cord-005081-kxrzv16n	241	8	of	of	IN
cord-005081-kxrzv16n	241	9	Influenza	Influenza	NNP
cord-005081-kxrzv16n	241	10	of	of	IN
cord-005081-kxrzv16n	241	11	the	the	DT
cord-005081-kxrzv16n	241	12	RAMS	RAMS	NNPS
cord-005081-kxrzv16n	241	13	with	with	IN
cord-005081-kxrzv16n	241	14	the	the	DT
cord-005081-kxrzv16n	241	15	GE	GE	NNP
cord-005081-kxrzv16n	241	16	Company	Company	NNP
cord-005081-kxrzv16n	241	17	(	(	-LRB-
cord-005081-kxrzv16n	241	18	Sweden	Sweden	NNP
cord-005081-kxrzv16n	241	19	)	)	-RRB-
cord-005081-kxrzv16n	241	20	includes	include	VBZ
cord-005081-kxrzv16n	241	21	a	a	DT
cord-005081-kxrzv16n	241	22	series	series	NN
cord-005081-kxrzv16n	241	23	of	of	IN
cord-005081-kxrzv16n	241	24	important	important	JJ
cord-005081-kxrzv16n	241	25	solutions	solution	NNS
cord-005081-kxrzv16n	241	26	for	for	IN
cord-005081-kxrzv16n	241	27	the	the	DT
cord-005081-kxrzv16n	241	28	key	key	JJ
cord-005081-kxrzv16n	241	29	part	part	NN
cord-005081-kxrzv16n	241	30	of	of	IN
cord-005081-kxrzv16n	241	31	the	the	DT
cord-005081-kxrzv16n	241	32	production	production	NN
cord-005081-kxrzv16n	241	33	cycle	cycle	NN
cord-005081-kxrzv16n	241	34	.	.	.
cord-005081-kxrzv16n	242	1	The	the	DT
cord-005081-kxrzv16n	242	2	system	system	NN
cord-005081-kxrzv16n	242	3	of	of	IN
cord-005081-kxrzv16n	242	4	cell	cell	NN
cord-005081-kxrzv16n	242	5	selection	selection	NN
cord-005081-kxrzv16n	242	6	,	,	,
cord-005081-kxrzv16n	242	7	concentration	concentration	NN
cord-005081-kxrzv16n	242	8	,	,	,
cord-005081-kxrzv16n	242	9	and	and	CC
cord-005081-kxrzv16n	242	10	filtration	filtration	NN
cord-005081-kxrzv16n	242	11	with	with	IN
cord-005081-kxrzv16n	242	12	separation	separation	NN
cord-005081-kxrzv16n	242	13	of	of	IN
cord-005081-kxrzv16n	242	14	the	the	DT
cord-005081-kxrzv16n	242	15	fractions	fraction	NNS
cord-005081-kxrzv16n	242	16	containing	contain	VBG
cord-005081-kxrzv16n	242	17	the	the	DT
cord-005081-kxrzv16n	242	18	end	end	NN
cord-005081-kxrzv16n	242	19	product	product	NN
cord-005081-kxrzv16n	242	20	is	be	VBZ
cord-005081-kxrzv16n	242	21	successfully	successfully	RB
cord-005081-kxrzv16n	242	22	realized	realize	VBN
cord-005081-kxrzv16n	242	23	using	use	VBG
cord-005081-kxrzv16n	242	24	the	the	DT
cord-005081-kxrzv16n	242	25	UniFlux	UniFlux	NNP
cord-005081-kxrzv16n	242	26	system	system	NN
cord-005081-kxrzv16n	242	27	developed	develop	VBN
cord-005081-kxrzv16n	242	28	within	within	IN
cord-005081-kxrzv16n	242	29	the	the	DT
cord-005081-kxrzv16n	242	30	above	above	JJ
cord-005081-kxrzv16n	242	31	project	project	NN
cord-005081-kxrzv16n	242	32	(	(	-LRB-
cord-005081-kxrzv16n	242	33	Fig	Fig	NNP
cord-005081-kxrzv16n	242	34	.	.	.
cord-005081-kxrzv16n	242	35	6	6	CD
cord-005081-kxrzv16n	242	36	)	)	-RRB-
cord-005081-kxrzv16n	242	37	.	.	.
cord-005081-kxrzv16n	243	1	UniFlux	uniflux	JJ
cord-005081-kxrzv16n	243	2	systems	system	NNS
cord-005081-kxrzv16n	243	3	can	can	MD
cord-005081-kxrzv16n	243	4	be	be	VB
cord-005081-kxrzv16n	243	5	used	use	VBN
cord-005081-kxrzv16n	243	6	for	for	IN
cord-005081-kxrzv16n	243	7	concentrating	concentrate	VBG
cord-005081-kxrzv16n	243	8	virus	virus	NN
cord-005081-kxrzv16n	243	9	suspensions	suspension	NNS
cord-005081-kxrzv16n	243	10	,	,	,
cord-005081-kxrzv16n	243	11	vaccine	vaccine	NN
cord-005081-kxrzv16n	243	12	preparations	preparation	NNS
cord-005081-kxrzv16n	243	13	,	,	,
cord-005081-kxrzv16n	243	14	protein	protein	NN
cord-005081-kxrzv16n	243	15	aggregates	aggregate	NNS
cord-005081-kxrzv16n	243	16	,	,	,
cord-005081-kxrzv16n	243	17	monoclonal	monoclonal	JJ
cord-005081-kxrzv16n	243	18	antibodies	antibody	NNS
cord-005081-kxrzv16n	243	19	,	,	,
cord-005081-kxrzv16n	243	20	and	and	CC
cord-005081-kxrzv16n	243	21	pure	pure	JJ
cord-005081-kxrzv16n	243	22	recom	recom	NNP
cord-005081-kxrzv16n	243	23	binant	binant	JJ
cord-005081-kxrzv16n	243	24	proteins	protein	NNS
cord-005081-kxrzv16n	243	25	.	.	.
cord-005081-kxrzv16n	244	1	Concentration	concentration	NN
cord-005081-kxrzv16n	244	2	of	of	IN
cord-005081-kxrzv16n	244	3	virus	virus	NN
cord-005081-kxrzv16n	244	4	suspensions	suspension	NNS
cord-005081-kxrzv16n	244	5	is	be	VBZ
cord-005081-kxrzv16n	244	6	a	a	DT
cord-005081-kxrzv16n	244	7	necessary	necessary	JJ
cord-005081-kxrzv16n	244	8	phase	phase	NN
cord-005081-kxrzv16n	244	9	for	for	IN
cord-005081-kxrzv16n	244	10	preparing	prepare	VBG
cord-005081-kxrzv16n	244	11	the	the	DT
cord-005081-kxrzv16n	244	12	material	material	NN
cord-005081-kxrzv16n	244	13	for	for	IN
cord-005081-kxrzv16n	244	14	chro	chro	NN
cord-005081-kxrzv16n	244	15	matographic	matographic	JJ
cord-005081-kxrzv16n	244	16	purification	purification	NN
cord-005081-kxrzv16n	244	17	.	.	.
cord-005081-kxrzv16n	245	1	The	the	DT
cord-005081-kxrzv16n	245	2	use	use	NN
cord-005081-kxrzv16n	245	3	of	of	IN
cord-005081-kxrzv16n	245	4	standard	standard	JJ
cord-005081-kxrzv16n	245	5	monolith	monolith	NN
cord-005081-kxrzv16n	245	6	columns	column	NNS
cord-005081-kxrzv16n	245	7	for	for	IN
cord-005081-kxrzv16n	245	8	the	the	DT
cord-005081-kxrzv16n	245	9	chromatography	chromatography	NN
cord-005081-kxrzv16n	245	10	of	of	IN
cord-005081-kxrzv16n	245	11	viral	viral	JJ
cord-005081-kxrzv16n	245	12	particles	particle	NNS
cord-005081-kxrzv16n	245	13	is	be	VBZ
cord-005081-kxrzv16n	245	14	the	the	DT
cord-005081-kxrzv16n	245	15	most	most	RBS
cord-005081-kxrzv16n	245	16	impor	impor	JJ
cord-005081-kxrzv16n	245	17	tant	tant	JJ
cord-005081-kxrzv16n	245	18	technological	technological	JJ
cord-005081-kxrzv16n	245	19	solution	solution	NN
cord-005081-kxrzv16n	245	20	(	(	-LRB-
cord-005081-kxrzv16n	245	21	Fig	Fig	NNP
cord-005081-kxrzv16n	245	22	.	.	NNP
cord-005081-kxrzv16n	245	23	7	7	CD
cord-005081-kxrzv16n	245	24	)	)	-RRB-
cord-005081-kxrzv16n	245	25	.	.	.
cord-005081-kxrzv16n	246	1	Under	under	IN
cord-005081-kxrzv16n	246	2	a	a	DT
cord-005081-kxrzv16n	246	3	majority	majority	NN
cord-005081-kxrzv16n	246	4	of	of	IN
cord-005081-kxrzv16n	246	5	technological	technological	JJ
cord-005081-kxrzv16n	246	6	processes	process	NNS
cord-005081-kxrzv16n	246	7	,	,	,
cord-005081-kxrzv16n	246	8	viral	viral	JJ
cord-005081-kxrzv16n	246	9	particles	particle	NNS
cord-005081-kxrzv16n	246	10	are	be	VBP
cord-005081-kxrzv16n	246	11	subjected	subject	VBN
cord-005081-kxrzv16n	246	12	to	to	IN
cord-005081-kxrzv16n	246	13	purification	purification	NN
cord-005081-kxrzv16n	246	14	through	through	IN
cord-005081-kxrzv16n	246	15	sucrose	sucrose	NN
cord-005081-kxrzv16n	246	16	gradient	gradient	NN
cord-005081-kxrzv16n	246	17	ultracentrifu	ultracentrifu	NN
cord-005081-kxrzv16n	246	18	gation	gation	NN
cord-005081-kxrzv16n	246	19	.	.	.
cord-005081-kxrzv16n	247	1	The	the	DT
cord-005081-kxrzv16n	247	2	chromatographically	chromatographically	RB
cord-005081-kxrzv16n	247	3	purified	purify	VBN
cord-005081-kxrzv16n	247	4	vaccine	vaccine	NN
cord-005081-kxrzv16n	247	5	was	be	VBD
cord-005081-kxrzv16n	247	6	obtained	obtain	VBN
cord-005081-kxrzv16n	247	7	in	in	IN
cord-005081-kxrzv16n	247	8	columns	column	NNS
cord-005081-kxrzv16n	247	9	with	with	IN
cord-005081-kxrzv16n	247	10	macroporous	macroporous	JJ
cord-005081-kxrzv16n	247	11	glass	glass	NN
cord-005081-kxrzv16n	247	12	.	.	.
cord-005081-kxrzv16n	248	1	How	how	WRB
cord-005081-kxrzv16n	248	2	ever	ever	RB
cord-005081-kxrzv16n	248	3	,	,	,
cord-005081-kxrzv16n	248	4	this	this	DT
cord-005081-kxrzv16n	248	5	vaccine	vaccine	NN
cord-005081-kxrzv16n	248	6	contained	contain	VBD
cord-005081-kxrzv16n	248	7	hydrodynamically	hydrodynamically	RB
cord-005081-kxrzv16n	248	8	and	and	CC
cord-005081-kxrzv16n	248	9	mechanically	mechanically	RB
cord-005081-kxrzv16n	248	10	destroyed	destroy	VBN
cord-005081-kxrzv16n	248	11	virions	virion	NNS
cord-005081-kxrzv16n	248	12	.	.	.
cord-005081-kxrzv16n	249	1	Exposing	expose	VBG
cord-005081-kxrzv16n	249	2	the	the	DT
cord-005081-kxrzv16n	249	3	viral	viral	JJ
cord-005081-kxrzv16n	249	4	nucleotide	nucleotide	NN
cord-005081-kxrzv16n	249	5	on	on	IN
cord-005081-kxrzv16n	249	6	the	the	DT
cord-005081-kxrzv16n	249	7	surface	surface	NN
cord-005081-kxrzv16n	249	8	of	of	IN
cord-005081-kxrzv16n	249	9	the	the	DT
cord-005081-kxrzv16n	249	10	destroyed	destroy	VBN
cord-005081-kxrzv16n	249	11	viral	viral	JJ
cord-005081-kxrzv16n	249	12	parti	parti	FW
cord-005081-kxrzv16n	249	13	cles	cles	FW
cord-005081-kxrzv16n	249	14	leads	lead	VBZ
cord-005081-kxrzv16n	249	15	to	to	IN
cord-005081-kxrzv16n	249	16	the	the	DT
cord-005081-kxrzv16n	249	17	induction	induction	NN
cord-005081-kxrzv16n	249	18	of	of	IN
cord-005081-kxrzv16n	249	19	immunity	immunity	NN
cord-005081-kxrzv16n	249	20	against	against	IN
cord-005081-kxrzv16n	249	21	the	the	DT
cord-005081-kxrzv16n	249	22	native	native	JJ
cord-005081-kxrzv16n	249	23	viral	viral	JJ
cord-005081-kxrzv16n	249	24	ribonucleoproteid	ribonucleoproteid	NN
cord-005081-kxrzv16n	249	25	(	(	-LRB-
cord-005081-kxrzv16n	249	26	RNP	RNP	NNP
cord-005081-kxrzv16n	249	27	)	)	-RRB-
cord-005081-kxrzv16n	249	28	.	.	.
cord-005081-kxrzv16n	250	1	This	this	DT
cord-005081-kxrzv16n	250	2	phenome	phenome	FW
cord-005081-kxrzv16n	250	3	non	non	FW
cord-005081-kxrzv16n	250	4	is	be	VBZ
cord-005081-kxrzv16n	250	5	not	not	RB
cord-005081-kxrzv16n	250	6	so	so	RB
cord-005081-kxrzv16n	250	7	unsafe	unsafe	JJ
cord-005081-kxrzv16n	250	8	,	,	,
cord-005081-kxrzv16n	250	9	since	since	IN
cord-005081-kxrzv16n	250	10	a	a	DT
cord-005081-kxrzv16n	250	11	cross	cross	NN
cord-005081-kxrzv16n	250	12	reaction	reaction	NN
cord-005081-kxrzv16n	250	13	of	of	IN
cord-005081-kxrzv16n	250	14	antibod	antibod	NNP
cord-005081-kxrzv16n	250	15	ies	ies	NNP
cord-005081-kxrzv16n	250	16	with	with	IN
cord-005081-kxrzv16n	250	17	RNP	RNP	NNP
cord-005081-kxrzv16n	250	18	of	of	IN
cord-005081-kxrzv16n	250	19	the	the	DT
cord-005081-kxrzv16n	250	20	body	body	NN
cord-005081-kxrzv16n	250	21	's	's	POS
cord-005081-kxrzv16n	250	22	cells	cell	NNS
cord-005081-kxrzv16n	250	23	can	can	MD
cord-005081-kxrzv16n	250	24	not	not	RB
cord-005081-kxrzv16n	250	25	be	be	VB
cord-005081-kxrzv16n	250	26	excluded	exclude	VBN
cord-005081-kxrzv16n	250	27	,	,	,
cord-005081-kxrzv16n	250	28	while	while	IN
cord-005081-kxrzv16n	250	29	this	this	DT
cord-005081-kxrzv16n	250	30	kind	kind	NN
cord-005081-kxrzv16n	250	31	of	of	IN
cord-005081-kxrzv16n	250	32	phenomena	phenomenon	NNS
cord-005081-kxrzv16n	250	33	may	may	MD
cord-005081-kxrzv16n	250	34	lead	lead	VB
cord-005081-kxrzv16n	250	35	to	to	IN
cord-005081-kxrzv16n	250	36	autoim	autoim	NNP
cord-005081-kxrzv16n	250	37	mune	mune	NNP
cord-005081-kxrzv16n	250	38	processes	process	NNS
cord-005081-kxrzv16n	250	39	that	that	WDT
cord-005081-kxrzv16n	250	40	may	may	MD
cord-005081-kxrzv16n	250	41	trigger	trigger	VB
cord-005081-kxrzv16n	250	42	systemic	systemic	JJ
cord-005081-kxrzv16n	250	43	diseases	disease	NNS
cord-005081-kxrzv16n	250	44	.	.	.
cord-005081-kxrzv16n	251	1	Application	application	NN
cord-005081-kxrzv16n	251	2	of	of	IN
cord-005081-kxrzv16n	251	3	state	state	NN
cord-005081-kxrzv16n	251	4	of	of	IN
cord-005081-kxrzv16n	251	5	the	the	DT
cord-005081-kxrzv16n	251	6	art	art	NN
cord-005081-kxrzv16n	251	7	techniques	technique	NNS
cord-005081-kxrzv16n	251	8	for	for	IN
cord-005081-kxrzv16n	251	9	chromatography	chromatography	NN
cord-005081-kxrzv16n	251	10	of	of	IN
cord-005081-kxrzv16n	251	11	viral	viral	JJ
cord-005081-kxrzv16n	251	12	particles	particle	NNS
cord-005081-kxrzv16n	251	13	permits	permit	VBZ
cord-005081-kxrzv16n	251	14	one	one	CD
cord-005081-kxrzv16n	251	15	to	to	TO
cord-005081-kxrzv16n	251	16	obtain	obtain	VB
cord-005081-kxrzv16n	251	17	highly	highly	RB
cord-005081-kxrzv16n	251	18	purified	purify	VBN
cord-005081-kxrzv16n	251	19	samples	sample	NNS
cord-005081-kxrzv16n	251	20	of	of	IN
cord-005081-kxrzv16n	251	21	both	both	DT
cord-005081-kxrzv16n	251	22	viruses	virus	NNS
cord-005081-kxrzv16n	251	23	and	and	CC
cord-005081-kxrzv16n	251	24	subunit	subunit	NN
cord-005081-kxrzv16n	251	25	preparations	preparation	NNS
cord-005081-kxrzv16n	251	26	or	or	CC
cord-005081-kxrzv16n	251	27	VLPs	vlp	NNS
cord-005081-kxrzv16n	251	28	.	.	.
cord-005081-kxrzv16n	252	1	Chromatographic	chromatographic	JJ
cord-005081-kxrzv16n	252	2	puri	puri	NN
cord-005081-kxrzv16n	252	3	fication	fication	NN
cord-005081-kxrzv16n	252	4	helps	help	VBZ
cord-005081-kxrzv16n	252	5	solve	solve	VB
cord-005081-kxrzv16n	252	6	another	another	DT
cord-005081-kxrzv16n	252	7	,	,	,
cord-005081-kxrzv16n	252	8	more	more	RBR
cord-005081-kxrzv16n	252	9	important	important	JJ
cord-005081-kxrzv16n	252	10	problem	problem	NN
cord-005081-kxrzv16n	252	11	.	.	.
cord-005081-kxrzv16n	253	1	Electron	electron	NN
cord-005081-kxrzv16n	253	2	microscopy	microscopy	NN
cord-005081-kxrzv16n	253	3	analysis	analysis	NN
cord-005081-kxrzv16n	253	4	of	of	IN
cord-005081-kxrzv16n	253	5	the	the	DT
cord-005081-kxrzv16n	253	6	current	current	JJ
cord-005081-kxrzv16n	253	7	vaccines	vaccine	NNS
cord-005081-kxrzv16n	253	8	as	as	IN
cord-005081-kxrzv16n	253	9	to	to	IN
cord-005081-kxrzv16n	253	10	their	-PRON-	PRP$
cord-005081-kxrzv16n	253	11	structure	structure	NN
cord-005081-kxrzv16n	253	12	reveals	reveal	VBZ
cord-005081-kxrzv16n	253	13	that	that	IN
cord-005081-kxrzv16n	253	14	antigens	antigen	NNS
cord-005081-kxrzv16n	253	15	in	in	IN
cord-005081-kxrzv16n	253	16	the	the	DT
cord-005081-kxrzv16n	253	17	major	major	JJ
cord-005081-kxrzv16n	253	18	ity	ity	NN
cord-005081-kxrzv16n	253	19	of	of	IN
cord-005081-kxrzv16n	253	20	vaccine	vaccine	NN
cord-005081-kxrzv16n	253	21	preparations	preparation	NNS
cord-005081-kxrzv16n	253	22	are	be	VBP
cord-005081-kxrzv16n	253	23	in	in	IN
cord-005081-kxrzv16n	253	24	a	a	DT
cord-005081-kxrzv16n	253	25	denatured	denatured	JJ
cord-005081-kxrzv16n	253	26	or	or	CC
cord-005081-kxrzv16n	253	27	heavily	heavily	RB
cord-005081-kxrzv16n	253	28	disorganized	disorganized	JJ
cord-005081-kxrzv16n	253	29	state	state	NN
cord-005081-kxrzv16n	253	30	(	(	-LRB-
cord-005081-kxrzv16n	253	31	Fig	Fig	NNP
cord-005081-kxrzv16n	253	32	.	.	.
cord-005081-kxrzv16n	253	33	8)	8)	NNP
cord-005081-kxrzv16n	253	34	.	.	.
cord-005081-kxrzv16n	254	1	The	the	DT
cord-005081-kxrzv16n	254	2	Research	Research	NNP
cord-005081-kxrzv16n	254	3	Institute	Institute	NNP
cord-005081-kxrzv16n	254	4	of	of	IN
cord-005081-kxrzv16n	254	5	Influenza	Influenza	NNP
cord-005081-kxrzv16n	254	6	of	of	IN
cord-005081-kxrzv16n	254	7	the	the	DT
cord-005081-kxrzv16n	254	8	RAMS	ram	NNS
cord-005081-kxrzv16n	254	9	is	be	VBZ
cord-005081-kxrzv16n	254	10	now	now	RB
cord-005081-kxrzv16n	254	11	developing	develop	VBG
cord-005081-kxrzv16n	254	12	,	,	,
cord-005081-kxrzv16n	254	13	within	within	IN
cord-005081-kxrzv16n	254	14	some	some	DT
cord-005081-kxrzv16n	254	15	international	international	JJ
cord-005081-kxrzv16n	254	16	projects	project	NNS
cord-005081-kxrzv16n	254	17	,	,	,
cord-005081-kxrzv16n	254	18	production	production	NN
cord-005081-kxrzv16n	254	19	technologies	technology	NNS
cord-005081-kxrzv16n	254	20	for	for	IN
cord-005081-kxrzv16n	254	21	a	a	DT
cord-005081-kxrzv16n	254	22	new	new	JJ
cord-005081-kxrzv16n	254	23	generation	generation	NN
cord-005081-kxrzv16n	254	24	of	of	IN
cord-005081-kxrzv16n	254	25	vac	vac	NN
cord-005081-kxrzv16n	254	26	cine	cine	NNP
cord-005081-kxrzv16n	254	27	preparations	preparation	NNS
cord-005081-kxrzv16n	254	28	:	:	:
cord-005081-kxrzv16n	254	29	(	(	-LRB-
cord-005081-kxrzv16n	254	30	1	1	LS
cord-005081-kxrzv16n	254	31	)	)	-RRB-
cord-005081-kxrzv16n	254	32	live	live	VBP
cord-005081-kxrzv16n	254	33	replicatively	replicatively	RB
cord-005081-kxrzv16n	254	34	deficient	deficient	JJ
cord-005081-kxrzv16n	254	35	vaccines	vaccine	NNS
cord-005081-kxrzv16n	254	36	Del	Del	NNP
cord-005081-kxrzv16n	254	37	NS1	NS1	NNS
cord-005081-kxrzv16n	254	38	with	with	IN
cord-005081-kxrzv16n	254	39	additional	additional	JJ
cord-005081-kxrzv16n	254	40	genetic	genetic	JJ
cord-005081-kxrzv16n	254	41	defects	defect	NNS
cord-005081-kxrzv16n	254	42	within	within	IN
cord-005081-kxrzv16n	254	43	a	a	DT
cord-005081-kxrzv16n	254	44	wide	wide	JJ
cord-005081-kxrzv16n	254	45	spectrum	spectrum	NN
cord-005081-kxrzv16n	254	46	of	of	IN
cord-005081-kxrzv16n	254	47	molecular	molecular	JJ
cord-005081-kxrzv16n	254	48	determinants	determinant	NNS
cord-005081-kxrzv16n	254	49	of	of	IN
cord-005081-kxrzv16n	254	50	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	254	51	for	for	IN
cord-005081-kxrzv16n	254	52	opti	opti	NNP
cord-005081-kxrzv16n	254	53	mizing	mize	VBG
cord-005081-kxrzv16n	254	54	their	-PRON-	PRP$
cord-005081-kxrzv16n	254	55	safety	safety	NN
cord-005081-kxrzv16n	254	56	and	and	CC
cord-005081-kxrzv16n	254	57	preserving	preserve	VBG
cord-005081-kxrzv16n	254	58	their	-PRON-	PRP$
cord-005081-kxrzv16n	254	59	high	high	JJ
cord-005081-kxrzv16n	254	60	immuno	immuno	JJ
cord-005081-kxrzv16n	254	61	genicity	genicity	NN
cord-005081-kxrzv16n	254	62	;	;	:
cord-005081-kxrzv16n	254	63	(	(	-LRB-
cord-005081-kxrzv16n	254	64	2	2	LS
cord-005081-kxrzv16n	254	65	)	)	-RRB-
cord-005081-kxrzv16n	254	66	protein	protein	NN
cord-005081-kxrzv16n	254	67	nanovaccines	nanovaccine	NNS
cord-005081-kxrzv16n	254	68	based	base	VBN
cord-005081-kxrzv16n	254	69	on	on	IN
cord-005081-kxrzv16n	254	70	the	the	DT
cord-005081-kxrzv16n	254	71	controlled	control	VBN
cord-005081-kxrzv16n	254	72	folding	folding	NN
cord-005081-kxrzv16n	254	73	technology	technology	NN
cord-005081-kxrzv16n	254	74	;	;	:
cord-005081-kxrzv16n	254	75	100	100	CD
cord-005081-kxrzv16n	254	76	nm	nm	NN
cord-005081-kxrzv16n	254	77	50	50	CD
cord-005081-kxrzv16n	254	78	nm	nm	NN
cord-005081-kxrzv16n	254	79	(	(	-LRB-
cord-005081-kxrzv16n	254	80	d	d	NN
cord-005081-kxrzv16n	254	81	)	)	-RRB-
cord-005081-kxrzv16n	254	82	(	(	-LRB-
cord-005081-kxrzv16n	254	83	3	3	LS
cord-005081-kxrzv16n	254	84	)	)	-RRB-
cord-005081-kxrzv16n	254	85	antigen	antigen	NN
cord-005081-kxrzv16n	254	86	and	and	CC
cord-005081-kxrzv16n	254	87	virion	virion	NN
cord-005081-kxrzv16n	254	88	complexes	complex	NNS
cord-005081-kxrzv16n	254	89	with	with	IN
cord-005081-kxrzv16n	254	90	metalized	metalized	JJ
cord-005081-kxrzv16n	254	91	nanoparticles	nanoparticle	NNS
cord-005081-kxrzv16n	254	92	(	(	-LRB-
cord-005081-kxrzv16n	254	93	Fig	Fig	NNP
cord-005081-kxrzv16n	254	94	.	.	.
cord-005081-kxrzv16n	254	95	9	9	CD
cord-005081-kxrzv16n	254	96	)	)	-RRB-
cord-005081-kxrzv16n	254	97	.	.	.
cord-005081-kxrzv16n	255	1	First	first	RB
cord-005081-kxrzv16n	255	2	of	of	IN
cord-005081-kxrzv16n	255	3	all	all	DT
cord-005081-kxrzv16n	255	4	,	,	,
cord-005081-kxrzv16n	255	5	we	-PRON-	PRP
cord-005081-kxrzv16n	255	6	should	should	MD
cord-005081-kxrzv16n	255	7	underline	underline	VB
cord-005081-kxrzv16n	255	8	that	that	IN
cord-005081-kxrzv16n	255	9	the	the	DT
cord-005081-kxrzv16n	255	10	principal	principal	JJ
cord-005081-kxrzv16n	255	11	strategy	strategy	NN
cord-005081-kxrzv16n	255	12	in	in	IN
cord-005081-kxrzv16n	255	13	improving	improve	VBG
cord-005081-kxrzv16n	255	14	influenza	influenza	NN
cord-005081-kxrzv16n	255	15	vaccines	vaccine	NNS
cord-005081-kxrzv16n	255	16	has	have	VBZ
cord-005081-kxrzv16n	255	17	ever	ever	RB
cord-005081-kxrzv16n	255	18	been	be	VBN
cord-005081-kxrzv16n	255	19	their	-PRON-	PRP$
cord-005081-kxrzv16n	255	20	increased	increase	VBN
cord-005081-kxrzv16n	255	21	safety	safety	NN
cord-005081-kxrzv16n	255	22	and	and	CC
cord-005081-kxrzv16n	255	23	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	255	24	.	.	.
cord-005081-kxrzv16n	256	1	This	this	DT
cord-005081-kxrzv16n	256	2	explains	explain	VBZ
cord-005081-kxrzv16n	256	3	the	the	DT
cord-005081-kxrzv16n	256	4	transition	transition	NN
cord-005081-kxrzv16n	256	5	from	from	IN
cord-005081-kxrzv16n	256	6	whole	whole	JJ
cord-005081-kxrzv16n	256	7	virion	virion	NN
cord-005081-kxrzv16n	256	8	to	to	TO
cord-005081-kxrzv16n	256	9	split	split	VB
cord-005081-kxrzv16n	256	10	vac	vac	NN
cord-005081-kxrzv16n	256	11	cines	cines	NNP
cord-005081-kxrzv16n	256	12	and	and	CC
cord-005081-kxrzv16n	256	13	from	from	IN
cord-005081-kxrzv16n	256	14	the	the	DT
cord-005081-kxrzv16n	256	15	latter	latter	JJ
cord-005081-kxrzv16n	256	16	to	to	IN
cord-005081-kxrzv16n	256	17	subunit	subunit	NN
cord-005081-kxrzv16n	256	18	vaccines	vaccine	NNS
cord-005081-kxrzv16n	256	19	.	.	.
cord-005081-kxrzv16n	257	1	A	a	DT
cord-005081-kxrzv16n	257	2	high	high	JJ
cord-005081-kxrzv16n	257	3	level	level	NN
cord-005081-kxrzv16n	257	4	of	of	IN
cord-005081-kxrzv16n	257	5	antigen	antigen	NN
cord-005081-kxrzv16n	257	6	purification	purification	NN
cord-005081-kxrzv16n	257	7	generated	generate	VBD
cord-005081-kxrzv16n	257	8	the	the	DT
cord-005081-kxrzv16n	257	9	problem	problem	NN
cord-005081-kxrzv16n	257	10	of	of	IN
cord-005081-kxrzv16n	257	11	decreased	decrease	VBN
cord-005081-kxrzv16n	257	12	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	257	13	of	of	IN
cord-005081-kxrzv16n	257	14	vaccines	vaccine	NNS
cord-005081-kxrzv16n	257	15	and	and	CC
cord-005081-kxrzv16n	257	16	a	a	DT
cord-005081-kxrzv16n	257	17	search	search	NN
cord-005081-kxrzv16n	257	18	for	for	IN
cord-005081-kxrzv16n	257	19	immunoadjuvants	immunoadjuvant	NNS
cord-005081-kxrzv16n	257	20	.	.	.
cord-005081-kxrzv16n	258	1	Approximately	approximately	RB
cord-005081-kxrzv16n	258	2	15	15	CD
cord-005081-kxrzv16n	258	3	years	year	NNS
cord-005081-kxrzv16n	258	4	ago	ago	RB
cord-005081-kxrzv16n	258	5	polyoxidonium	polyoxidonium	NNP
cord-005081-kxrzv16n	258	6	was	be	VBD
cord-005081-kxrzv16n	258	7	selected	select	VBN
cord-005081-kxrzv16n	258	8	to	to	TO
cord-005081-kxrzv16n	258	9	perform	perform	VB
cord-005081-kxrzv16n	258	10	this	this	DT
cord-005081-kxrzv16n	258	11	function	function	NN
cord-005081-kxrzv16n	258	12	.	.	.
cord-005081-kxrzv16n	259	1	The	the	DT
cord-005081-kxrzv16n	259	2	polyoxidonium	polyoxidonium	NN
cord-005081-kxrzv16n	259	3	based	base	VBN
cord-005081-kxrzv16n	259	4	vaccines	vaccine	NNS
cord-005081-kxrzv16n	259	5	were	be	VBD
cord-005081-kxrzv16n	259	6	termed	term	VBN
cord-005081-kxrzv16n	259	7	poly	poly	NNP
cord-005081-kxrzv16n	259	8	mer	mer	NNP
cord-005081-kxrzv16n	259	9	subunit	subunit	NNP
cord-005081-kxrzv16n	259	10	vaccines	vaccine	NNS
cord-005081-kxrzv16n	259	11	.	.	.
cord-005081-kxrzv16n	260	1	However	however	RB
cord-005081-kxrzv16n	260	2	,	,	,
cord-005081-kxrzv16n	260	3	such	such	PDT
cord-005081-kxrzv16n	260	4	an	an	DT
cord-005081-kxrzv16n	260	5	approach	approach	NN
cord-005081-kxrzv16n	260	6	has	have	VBZ
cord-005081-kxrzv16n	260	7	grown	grow	VBN
cord-005081-kxrzv16n	260	8	old	old	JJ
cord-005081-kxrzv16n	260	9	now	now	RB
cord-005081-kxrzv16n	260	10	.	.	.
cord-005081-kxrzv16n	261	1	A	a	DT
cord-005081-kxrzv16n	261	2	number	number	NN
cord-005081-kxrzv16n	261	3	of	of	IN
cord-005081-kxrzv16n	261	4	new	new	JJ
cord-005081-kxrzv16n	261	5	adjuvants	adjuvant	NNS
cord-005081-kxrzv16n	261	6	based	base	VBN
cord-005081-kxrzv16n	261	7	on	on	IN
cord-005081-kxrzv16n	261	8	the	the	DT
cord-005081-kxrzv16n	261	9	known	know	VBN
cord-005081-kxrzv16n	261	10	mechanism	mechanism	NN
cord-005081-kxrzv16n	261	11	of	of	IN
cord-005081-kxrzv16n	261	12	stimulating	stimulate	VBG
cord-005081-kxrzv16n	261	13	the	the	DT
cord-005081-kxrzv16n	261	14	immune	immune	JJ
cord-005081-kxrzv16n	261	15	response	response	NN
cord-005081-kxrzv16n	261	16	through	through	IN
cord-005081-kxrzv16n	261	17	Toll	toll	NN
cord-005081-kxrzv16n	261	18	receptors	receptor	NNS
cord-005081-kxrzv16n	261	19	have	have	VBP
cord-005081-kxrzv16n	261	20	been	be	VBN
cord-005081-kxrzv16n	261	21	tested	test	VBN
cord-005081-kxrzv16n	261	22	in	in	IN
cord-005081-kxrzv16n	261	23	recent	recent	JJ
cord-005081-kxrzv16n	261	24	years	year	NNS
cord-005081-kxrzv16n	261	25	[	[	-LRB-
cord-005081-kxrzv16n	261	26	12	12	CD
cord-005081-kxrzv16n	261	27	,	,	,
cord-005081-kxrzv16n	261	28	29	29	CD
cord-005081-kxrzv16n	261	29	]	]	-RRB-
cord-005081-kxrzv16n	261	30	.	.	.
cord-005081-kxrzv16n	262	1	Discussions	discussion	NNS
cord-005081-kxrzv16n	262	2	are	be	VBP
cord-005081-kxrzv16n	262	3	still	still	RB
cord-005081-kxrzv16n	262	4	ongoing	ongoing	JJ
cord-005081-kxrzv16n	262	5	concerning	concern	VBG
cord-005081-kxrzv16n	262	6	the	the	DT
cord-005081-kxrzv16n	262	7	safety	safety	NN
cord-005081-kxrzv16n	262	8	of	of	IN
cord-005081-kxrzv16n	262	9	LAIV	LAIV	NNP
cord-005081-kxrzv16n	262	10	.	.	.
cord-005081-kxrzv16n	263	1	The	the	DT
cord-005081-kxrzv16n	263	2	current	current	JJ
cord-005081-kxrzv16n	263	3	strategy	strategy	NN
cord-005081-kxrzv16n	263	4	is	be	VBZ
cord-005081-kxrzv16n	263	5	oriented	orient	VBN
cord-005081-kxrzv16n	263	6	to	to	IN
cord-005081-kxrzv16n	263	7	a	a	DT
cord-005081-kxrzv16n	263	8	search	search	NN
cord-005081-kxrzv16n	263	9	for	for	IN
cord-005081-kxrzv16n	263	10	inactivated	inactivate	VBN
cord-005081-kxrzv16n	263	11	analogues	analogue	NNS
cord-005081-kxrzv16n	263	12	of	of	IN
cord-005081-kxrzv16n	263	13	many	many	JJ
cord-005081-kxrzv16n	263	14	live	live	JJ
cord-005081-kxrzv16n	263	15	vaccines	vaccine	NNS
cord-005081-kxrzv16n	263	16	.	.	.
cord-005081-kxrzv16n	264	1	Firstly	firstly	RB
cord-005081-kxrzv16n	264	2	,	,	,
cord-005081-kxrzv16n	264	3	this	this	DT
cord-005081-kxrzv16n	264	4	is	be	VBZ
cord-005081-kxrzv16n	264	5	connected	connect	VBN
cord-005081-kxrzv16n	264	6	with	with	IN
cord-005081-kxrzv16n	264	7	a	a	DT
cord-005081-kxrzv16n	264	8	probable	probable	JJ
cord-005081-kxrzv16n	264	9	reversibility	reversibility	NN
cord-005081-kxrzv16n	264	10	of	of	IN
cord-005081-kxrzv16n	264	11	attenuated	attenuated	JJ
cord-005081-kxrzv16n	264	12	strains	strain	NNS
cord-005081-kxrzv16n	264	13	of	of	IN
cord-005081-kxrzv16n	264	14	viruses	virus	NNS
cord-005081-kxrzv16n	264	15	towards	towards	IN
cord-005081-kxrzv16n	264	16	wild	wild	JJ
cord-005081-kxrzv16n	264	17	types	type	NNS
cord-005081-kxrzv16n	264	18	,	,	,
cord-005081-kxrzv16n	264	19	or	or	CC
cord-005081-kxrzv16n	264	20	reassortment	reassortment	NN
cord-005081-kxrzv16n	264	21	of	of	IN
cord-005081-kxrzv16n	264	22	strains	strain	NNS
cord-005081-kxrzv16n	264	23	,	,	,
cord-005081-kxrzv16n	264	24	having	have	VBG
cord-005081-kxrzv16n	264	25	a	a	DT
cord-005081-kxrzv16n	264	26	fragmentary	fragmentary	JJ
cord-005081-kxrzv16n	264	27	genome	genome	NN
cord-005081-kxrzv16n	264	28	,	,	,
cord-005081-kxrzv16n	264	29	with	with	IN
cord-005081-kxrzv16n	264	30	wild	wild	JJ
cord-005081-kxrzv16n	264	31	viruses	virus	NNS
cord-005081-kxrzv16n	264	32	.	.	.
cord-005081-kxrzv16n	265	1	Using	use	VBG
cord-005081-kxrzv16n	265	2	a	a	DT
cord-005081-kxrzv16n	265	3	live	live	JJ
cord-005081-kxrzv16n	265	4	or	or	CC
cord-005081-kxrzv16n	265	5	even	even	RB
cord-005081-kxrzv16n	265	6	attenuated	attenuated	JJ
cord-005081-kxrzv16n	265	7	virus	virus	NN
cord-005081-kxrzv16n	265	8	for	for	IN
cord-005081-kxrzv16n	265	9	mass	mass	JJ
cord-005081-kxrzv16n	265	10	vaccination	vaccination	NN
cord-005081-kxrzv16n	265	11	,	,	,
cord-005081-kxrzv16n	265	12	we	-PRON-	PRP
cord-005081-kxrzv16n	265	13	,	,	,
cord-005081-kxrzv16n	265	14	certainly	certainly	RB
cord-005081-kxrzv16n	265	15	,	,	,
cord-005081-kxrzv16n	265	16	create	create	VB
cord-005081-kxrzv16n	265	17	a	a	DT
cord-005081-kxrzv16n	265	18	temporary	temporary	JJ
cord-005081-kxrzv16n	265	19	circulatory	circulatory	JJ
cord-005081-kxrzv16n	265	20	background	background	NN
cord-005081-kxrzv16n	265	21	,	,	,
cord-005081-kxrzv16n	265	22	considerably	considerably	RB
cord-005081-kxrzv16n	265	23	increasing	increase	VBG
cord-005081-kxrzv16n	265	24	a	a	DT
cord-005081-kxrzv16n	265	25	probability	probability	NN
cord-005081-kxrzv16n	265	26	for	for	IN
cord-005081-kxrzv16n	265	27	the	the	DT
cord-005081-kxrzv16n	265	28	reassortment	reassortment	NN
cord-005081-kxrzv16n	265	29	of	of	IN
cord-005081-kxrzv16n	265	30	viral	viral	JJ
cord-005081-kxrzv16n	265	31	genomes	genome	NNS
cord-005081-kxrzv16n	265	32	with	with	IN
cord-005081-kxrzv16n	265	33	viruses	virus	NNS
cord-005081-kxrzv16n	265	34	actively	actively	RB
cord-005081-kxrzv16n	265	35	circulating	circulate	VBG
cord-005081-kxrzv16n	265	36	in	in	IN
cord-005081-kxrzv16n	265	37	a	a	DT
cord-005081-kxrzv16n	265	38	current	current	JJ
cord-005081-kxrzv16n	265	39	period	period	NN
cord-005081-kxrzv16n	265	40	of	of	IN
cord-005081-kxrzv16n	265	41	time	time	NN
cord-005081-kxrzv16n	265	42	in	in	IN
cord-005081-kxrzv16n	265	43	human	human	JJ
cord-005081-kxrzv16n	265	44	population	population	NN
cord-005081-kxrzv16n	265	45	.	.	.
cord-005081-kxrzv16n	266	1	Despite	despite	IN
cord-005081-kxrzv16n	266	2	the	the	DT
cord-005081-kxrzv16n	266	3	fact	fact	NN
cord-005081-kxrzv16n	266	4	that	that	IN
cord-005081-kxrzv16n	266	5	the	the	DT
cord-005081-kxrzv16n	266	6	phe	phe	NNP
cord-005081-kxrzv16n	266	7	nomenon	nomenon	NNP
cord-005081-kxrzv16n	266	8	of	of	IN
cord-005081-kxrzv16n	266	9	reassortment	reassortment	NN
cord-005081-kxrzv16n	266	10	between	between	IN
cord-005081-kxrzv16n	266	11	LAIV	LAIV	NNP
cord-005081-kxrzv16n	266	12	and	and	CC
cord-005081-kxrzv16n	266	13	wild	wild	JJ
cord-005081-kxrzv16n	266	14	viruses	virus	NNS
cord-005081-kxrzv16n	266	15	has	have	VBZ
cord-005081-kxrzv16n	266	16	not	not	RB
cord-005081-kxrzv16n	266	17	been	be	VBN
cord-005081-kxrzv16n	266	18	confirmed	confirm	VBN
cord-005081-kxrzv16n	266	19	and	and	CC
cord-005081-kxrzv16n	266	20	viruses	virus	NNS
cord-005081-kxrzv16n	266	21	with	with	IN
cord-005081-kxrzv16n	266	22	signs	sign	NNS
cord-005081-kxrzv16n	266	23	of	of	IN
cord-005081-kxrzv16n	266	24	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	266	25	have	have	VBP
cord-005081-kxrzv16n	266	26	not	not	RB
cord-005081-kxrzv16n	266	27	been	be	VBN
cord-005081-kxrzv16n	266	28	isolated	isolate	VBN
cord-005081-kxrzv16n	266	29	in	in	IN
cord-005081-kxrzv16n	266	30	the	the	DT
cord-005081-kxrzv16n	266	31	majority	majority	NN
cord-005081-kxrzv16n	266	32	of	of	IN
cord-005081-kxrzv16n	266	33	complicated	complicated	JJ
cord-005081-kxrzv16n	266	34	vaccination	vaccination	NN
cord-005081-kxrzv16n	266	35	cases	case	NNS
cord-005081-kxrzv16n	266	36	,	,	,
cord-005081-kxrzv16n	266	37	the	the	DT
cord-005081-kxrzv16n	266	38	application	application	NN
cord-005081-kxrzv16n	266	39	of	of	IN
cord-005081-kxrzv16n	266	40	LAIV	LAIV	NNP
cord-005081-kxrzv16n	266	41	is	be	VBZ
cord-005081-kxrzv16n	266	42	limited	limit	VBN
cord-005081-kxrzv16n	266	43	in	in	IN
cord-005081-kxrzv16n	266	44	the	the	DT
cord-005081-kxrzv16n	266	45	period	period	NN
cord-005081-kxrzv16n	266	46	when	when	WRB
cord-005081-kxrzv16n	266	47	seasonal	seasonal	JJ
cord-005081-kxrzv16n	266	48	influenza	influenza	NN
cord-005081-kxrzv16n	266	49	is	be	VBZ
cord-005081-kxrzv16n	266	50	on	on	IN
cord-005081-kxrzv16n	266	51	the	the	DT
cord-005081-kxrzv16n	266	52	rise	rise	NN
cord-005081-kxrzv16n	266	53	.	.	.
cord-005081-kxrzv16n	267	1	Mass	mass	JJ
cord-005081-kxrzv16n	267	2	immunization	immunization	NN
cord-005081-kxrzv16n	267	3	with	with	IN
cord-005081-kxrzv16n	267	4	LAIV	LAIV	NNP
cord-005081-kxrzv16n	267	5	in	in	IN
cord-005081-kxrzv16n	267	6	the	the	DT
cord-005081-kxrzv16n	267	7	event	event	NN
cord-005081-kxrzv16n	267	8	of	of	IN
cord-005081-kxrzv16n	267	9	a	a	DT
cord-005081-kxrzv16n	267	10	pandemic	pandemic	NN
cord-005081-kxrzv16n	267	11	should	should	MD
cord-005081-kxrzv16n	267	12	be	be	VB
cord-005081-kxrzv16n	267	13	conducted	conduct	VBN
cord-005081-kxrzv16n	267	14	with	with	IN
cord-005081-kxrzv16n	267	15	maxi	maxi	NNP
cord-005081-kxrzv16n	267	16	mum	mum	NNP
cord-005081-kxrzv16n	267	17	care	care	NN
cord-005081-kxrzv16n	267	18	.	.	.
cord-005081-kxrzv16n	268	1	At	at	IN
cord-005081-kxrzv16n	268	2	the	the	DT
cord-005081-kxrzv16n	268	3	same	same	JJ
cord-005081-kxrzv16n	268	4	time	time	NN
cord-005081-kxrzv16n	268	5	,	,	,
cord-005081-kxrzv16n	268	6	improvement	improvement	NN
cord-005081-kxrzv16n	268	7	of	of	IN
cord-005081-kxrzv16n	268	8	LAIV	LAIV	NNP
cord-005081-kxrzv16n	268	9	safety	safety	NN
cord-005081-kxrzv16n	268	10	is	be	VBZ
cord-005081-kxrzv16n	268	11	possible	possible	JJ
cord-005081-kxrzv16n	268	12	through	through	IN
cord-005081-kxrzv16n	268	13	genetic	genetic	JJ
cord-005081-kxrzv16n	268	14	techniques	technique	NNS
cord-005081-kxrzv16n	268	15	-	-	:
cord-005081-kxrzv16n	268	16	in	in	IN
cord-005081-kxrzv16n	268	17	particular	particular	JJ
cord-005081-kxrzv16n	268	18	,	,	,
cord-005081-kxrzv16n	268	19	we	-PRON-	PRP
cord-005081-kxrzv16n	268	20	have	have	VBP
cord-005081-kxrzv16n	268	21	achieved	achieve	VBN
cord-005081-kxrzv16n	268	22	this	this	DT
cord-005081-kxrzv16n	268	23	in	in	IN
cord-005081-kxrzv16n	268	24	our	-PRON-	PRP$
cord-005081-kxrzv16n	268	25	studies	study	NNS
cord-005081-kxrzv16n	268	26	within	within	IN
cord-005081-kxrzv16n	268	27	the	the	DT
cord-005081-kxrzv16n	268	28	Euro	Euro	NNP
cord-005081-kxrzv16n	268	29	pean	pean	NNP
cord-005081-kxrzv16n	268	30	FluVac	FluVac	NNP
cord-005081-kxrzv16n	268	31	project	project	NN
cord-005081-kxrzv16n	268	32	.	.	.
cord-005081-kxrzv16n	269	1	The	the	DT
cord-005081-kxrzv16n	269	2	team	team	NN
cord-005081-kxrzv16n	269	3	led	lead	VBN
cord-005081-kxrzv16n	269	4	by	by	IN
cord-005081-kxrzv16n	269	5	Professor	Professor	NNP
cord-005081-kxrzv16n	269	6	A.Yu	A.Yu	NNP
cord-005081-kxrzv16n	269	7	.	.	.
cord-005081-kxrzv16n	270	1	Egorov	Egorov	NNP
cord-005081-kxrzv16n	270	2	has	have	VBZ
cord-005081-kxrzv16n	270	3	developed	develop	VBN
cord-005081-kxrzv16n	270	4	so	so	RB
cord-005081-kxrzv16n	270	5	called	call	VBN
cord-005081-kxrzv16n	270	6	DelNS1	delns1	CD
cord-005081-kxrzv16n	270	7	vac	vac	NNP
cord-005081-kxrzv16n	270	8	cines	cines	NNP
cord-005081-kxrzv16n	270	9	.	.	.
cord-005081-kxrzv16n	271	1	Vaccine	vaccine	NN
cord-005081-kxrzv16n	271	2	strains	strain	NNS
cord-005081-kxrzv16n	271	3	carrying	carry	VBG
cord-005081-kxrzv16n	271	4	the	the	DT
cord-005081-kxrzv16n	271	5	NSI	NSI	NNP
cord-005081-kxrzv16n	271	6	gene	gene	NN
cord-005081-kxrzv16n	271	7	deletion	deletion	NN
cord-005081-kxrzv16n	271	8	can	can	MD
cord-005081-kxrzv16n	271	9	quickly	quickly	RB
cord-005081-kxrzv16n	271	10	be	be	VB
cord-005081-kxrzv16n	271	11	eliminated	eliminate	VBN
cord-005081-kxrzv16n	271	12	,	,	,
cord-005081-kxrzv16n	271	13	since	since	IN
cord-005081-kxrzv16n	271	14	they	-PRON-	PRP
cord-005081-kxrzv16n	271	15	are	be	VBP
cord-005081-kxrzv16n	271	16	highly	highly	RB
cord-005081-kxrzv16n	271	17	sensi	sensi	JJ
cord-005081-kxrzv16n	271	18	tive	tive	NN
cord-005081-kxrzv16n	271	19	to	to	IN
cord-005081-kxrzv16n	271	20	the	the	DT
cord-005081-kxrzv16n	271	21	endogenous	endogenous	JJ
cord-005081-kxrzv16n	271	22	interferon	interferon	NN
cord-005081-kxrzv16n	272	1	(	(	-LRB-
cord-005081-kxrzv16n	272	2	the	the	DT
cord-005081-kxrzv16n	272	3	latter	latter	JJ
cord-005081-kxrzv16n	272	4	is	be	VBZ
cord-005081-kxrzv16n	272	5	the	the	DT
cord-005081-kxrzv16n	272	6	antagonist	antagonist	NN
cord-005081-kxrzv16n	272	7	of	of	IN
cord-005081-kxrzv16n	272	8	type	type	NN
cord-005081-kxrzv16n	272	9	I	-PRON-	PRP
cord-005081-kxrzv16n	272	10	and	and	CC
cord-005081-kxrzv16n	272	11	type	type	NN
cord-005081-kxrzv16n	272	12	II	ii	CD
cord-005081-kxrzv16n	272	13	interferons	interferon	NNS
cord-005081-kxrzv16n	272	14	)	)	-RRB-
cord-005081-kxrzv16n	272	15	.	.	.
cord-005081-kxrzv16n	273	1	There	there	EX
cord-005081-kxrzv16n	273	2	fore	fore	RB
cord-005081-kxrzv16n	273	3	,	,	,
cord-005081-kxrzv16n	273	4	this	this	DT
cord-005081-kxrzv16n	273	5	type	type	NN
cord-005081-kxrzv16n	273	6	of	of	IN
cord-005081-kxrzv16n	273	7	live	live	JJ
cord-005081-kxrzv16n	273	8	vaccine	vaccine	NN
cord-005081-kxrzv16n	273	9	was	be	VBD
cord-005081-kxrzv16n	273	10	classified	classify	VBN
cord-005081-kxrzv16n	273	11	as	as	IN
cord-005081-kxrzv16n	273	12	replica	replica	NN
cord-005081-kxrzv16n	273	13	tively	tively	RB
cord-005081-kxrzv16n	273	14	deficient	deficient	JJ
cord-005081-kxrzv16n	273	15	.	.	.
cord-005081-kxrzv16n	274	1	A	a	DT
cord-005081-kxrzv16n	274	2	probability	probability	NN
cord-005081-kxrzv16n	274	3	of	of	IN
cord-005081-kxrzv16n	274	4	recombination	recombination	NN
cord-005081-kxrzv16n	274	5	or	or	CC
cord-005081-kxrzv16n	274	6	reassortment	reassortment	NN
cord-005081-kxrzv16n	274	7	is	be	VBZ
cord-005081-kxrzv16n	274	8	ultimately	ultimately	RB
cord-005081-kxrzv16n	274	9	low	low	JJ
cord-005081-kxrzv16n	274	10	in	in	IN
cord-005081-kxrzv16n	274	11	this	this	DT
cord-005081-kxrzv16n	274	12	case	case	NN
cord-005081-kxrzv16n	274	13	.	.	.
cord-005081-kxrzv16n	275	1	Another	another	DT
cord-005081-kxrzv16n	275	2	approach	approach	NN
cord-005081-kxrzv16n	275	3	to	to	IN
cord-005081-kxrzv16n	275	4	a	a	DT
cord-005081-kxrzv16n	275	5	genetically	genetically	RB
cord-005081-kxrzv16n	275	6	controlled	control	VBN
cord-005081-kxrzv16n	275	7	reduction	reduction	NN
cord-005081-kxrzv16n	275	8	in	in	IN
cord-005081-kxrzv16n	275	9	the	the	DT
cord-005081-kxrzv16n	275	10	LAIV	LAIV	NNP
cord-005081-kxrzv16n	275	11	reactogenicity	reactogenicity	NN
cord-005081-kxrzv16n	275	12	consists	consist	VBZ
cord-005081-kxrzv16n	275	13	in	in	IN
cord-005081-kxrzv16n	275	14	the	the	DT
cord-005081-kxrzv16n	275	15	removal	removal	NN
cord-005081-kxrzv16n	275	16	of	of	IN
cord-005081-kxrzv16n	275	17	the	the	DT
cord-005081-kxrzv16n	275	18	reading	reading	NN
cord-005081-kxrzv16n	275	19	frame	frame	NN
cord-005081-kxrzv16n	275	20	in	in	IN
cord-005081-kxrzv16n	275	21	the	the	DT
cord-005081-kxrzv16n	275	22	PB1	PB1	NNP
cord-005081-kxrzv16n	275	23	gene	gene	NN
cord-005081-kxrzv16n	275	24	.	.	.
cord-005081-kxrzv16n	276	1	The	the	DT
cord-005081-kxrzv16n	276	2	PB1	pb1	NN
cord-005081-kxrzv16n	276	3	F2	F2	NNP
cord-005081-kxrzv16n	276	4	reading	reading	NN
cord-005081-kxrzv16n	276	5	frame	frame	NN
cord-005081-kxrzv16n	276	6	encodes	encode	VBZ
cord-005081-kxrzv16n	276	7	a	a	DT
cord-005081-kxrzv16n	276	8	short	short	JJ
cord-005081-kxrzv16n	276	9	protein	protein	NN
cord-005081-kxrzv16n	276	10	of	of	IN
cord-005081-kxrzv16n	276	11	87	87	CD
cord-005081-kxrzv16n	276	12	amino	amino	JJ
cord-005081-kxrzv16n	276	13	acids	acid	NNS
cord-005081-kxrzv16n	276	14	-	-	:
cord-005081-kxrzv16n	276	15	the	the	DT
cord-005081-kxrzv16n	276	16	factor	factor	NN
cord-005081-kxrzv16n	276	17	of	of	IN
cord-005081-kxrzv16n	276	18	macrophage	macrophage	NN
cord-005081-kxrzv16n	276	19	apoptosis	apoptosis	NN
cord-005081-kxrzv16n	276	20	causing	cause	VBG
cord-005081-kxrzv16n	276	21	the	the	DT
cord-005081-kxrzv16n	276	22	death	death	NN
cord-005081-kxrzv16n	276	23	of	of	IN
cord-005081-kxrzv16n	276	24	cells	cell	NNS
cord-005081-kxrzv16n	276	25	during	during	IN
cord-005081-kxrzv16n	276	26	translocation	translocation	NN
cord-005081-kxrzv16n	276	27	in	in	IN
cord-005081-kxrzv16n	276	28	mito	mito	NNP
cord-005081-kxrzv16n	277	1	The	the	DT
cord-005081-kxrzv16n	277	2	analysis	analysis	NN
cord-005081-kxrzv16n	277	3	of	of	IN
cord-005081-kxrzv16n	277	4	development	development	NN
cord-005081-kxrzv16n	277	5	strategies	strategy	NNS
cord-005081-kxrzv16n	277	6	in	in	IN
cord-005081-kxrzv16n	277	7	vaccine	vaccine	NN
cord-005081-kxrzv16n	277	8	production	production	NN
cord-005081-kxrzv16n	277	9	technology	technology	NN
cord-005081-kxrzv16n	277	10	has	have	VBZ
cord-005081-kxrzv16n	277	11	shown	show	VBN
cord-005081-kxrzv16n	277	12	that	that	IN
cord-005081-kxrzv16n	277	13	genetic	genetic	JJ
cord-005081-kxrzv16n	277	14	engi	engi	NNP
cord-005081-kxrzv16n	277	15	neering	neering	NNP
cord-005081-kxrzv16n	277	16	technologies	technology	NNS
cord-005081-kxrzv16n	277	17	are	be	VBP
cord-005081-kxrzv16n	277	18	moving	move	VBG
cord-005081-kxrzv16n	277	19	ever	ever	RB
cord-005081-kxrzv16n	277	20	more	more	JJR
cord-005081-kxrzv16n	277	21	to	to	IN
cord-005081-kxrzv16n	277	22	the	the	DT
cord-005081-kxrzv16n	277	23	fore	fore	JJ
cord-005081-kxrzv16n	277	24	front	front	NN
cord-005081-kxrzv16n	277	25	of	of	IN
cord-005081-kxrzv16n	277	26	this	this	DT
cord-005081-kxrzv16n	277	27	development	development	NN
cord-005081-kxrzv16n	277	28	.	.	.
cord-005081-kxrzv16n	278	1	On	on	IN
cord-005081-kxrzv16n	278	2	the	the	DT
cord-005081-kxrzv16n	278	3	other	other	JJ
cord-005081-kxrzv16n	278	4	hand	hand	NN
cord-005081-kxrzv16n	278	5	,	,	,
cord-005081-kxrzv16n	278	6	there	there	EX
cord-005081-kxrzv16n	278	7	is	be	VBZ
cord-005081-kxrzv16n	278	8	an	an	DT
cord-005081-kxrzv16n	278	9	understanding	understanding	NN
cord-005081-kxrzv16n	278	10	,	,	,
cord-005081-kxrzv16n	278	11	initially	initially	RB
cord-005081-kxrzv16n	278	12	absent	absent	JJ
cord-005081-kxrzv16n	278	13	in	in	IN
cord-005081-kxrzv16n	278	14	immunologists	immunologist	NNS
cord-005081-kxrzv16n	278	15	,	,	,
cord-005081-kxrzv16n	278	16	that	that	IN
cord-005081-kxrzv16n	278	17	the	the	DT
cord-005081-kxrzv16n	278	18	tertiary	tertiary	JJ
cord-005081-kxrzv16n	278	19	structure	structure	NN
cord-005081-kxrzv16n	278	20	of	of	IN
cord-005081-kxrzv16n	278	21	the	the	DT
cord-005081-kxrzv16n	278	22	antigen	antigen	NN
cord-005081-kxrzv16n	278	23	is	be	VBZ
cord-005081-kxrzv16n	278	24	equally	equally	RB
cord-005081-kxrzv16n	278	25	important	important	JJ
cord-005081-kxrzv16n	278	26	for	for	IN
cord-005081-kxrzv16n	278	27	adequate	adequate	JJ
cord-005081-kxrzv16n	278	28	immunogenicity	immunogenicity	NN
cord-005081-kxrzv16n	278	29	and	and	CC
cord-005081-kxrzv16n	278	30	the	the	DT
cord-005081-kxrzv16n	278	31	func	func	NN
cord-005081-kxrzv16n	278	32	tioning	tioning	NN
cord-005081-kxrzv16n	278	33	of	of	IN
cord-005081-kxrzv16n	278	34	enzymes	enzyme	NNS
cord-005081-kxrzv16n	278	35	.	.	.
cord-005081-kxrzv16n	279	1	Significantly	significantly	RB
cord-005081-kxrzv16n	279	2	improved	improve	VBD
cord-005081-kxrzv16n	279	3	instru	instru	NNP
cord-005081-kxrzv16n	279	4	mental	mental	JJ
cord-005081-kxrzv16n	279	5	provision	provision	NN
cord-005081-kxrzv16n	279	6	of	of	IN
cord-005081-kxrzv16n	279	7	technological	technological	JJ
cord-005081-kxrzv16n	279	8	processes	process	NNS
cord-005081-kxrzv16n	279	9	enables	enable	VBZ
cord-005081-kxrzv16n	279	10	creating	create	VBG
cord-005081-kxrzv16n	279	11	typical	typical	JJ
cord-005081-kxrzv16n	279	12	multipurpose	multipurpose	JJ
cord-005081-kxrzv16n	279	13	vaccine	vaccine	NN
cord-005081-kxrzv16n	279	14	productions	production	NNS
cord-005081-kxrzv16n	279	15	,	,	,
cord-005081-kxrzv16n	279	16	including	include	VBG
cord-005081-kxrzv16n	279	17	vaccine	vaccine	NN
cord-005081-kxrzv16n	279	18	preparations	preparation	NNS
cord-005081-kxrzv16n	279	19	based	base	VBN
cord-005081-kxrzv16n	279	20	on	on	IN
cord-005081-kxrzv16n	279	21	nanotechnol	nanotechnol	NNP
cord-005081-kxrzv16n	279	22	ogies	ogie	NNS
cord-005081-kxrzv16n	279	23	.	.	.
cord-005081-kxrzv16n	280	1	The	the	DT
cord-005081-kxrzv16n	280	2	current	current	JJ
cord-005081-kxrzv16n	280	3	discussions	discussion	NNS
cord-005081-kxrzv16n	280	4	about	about	IN
cord-005081-kxrzv16n	280	5	the	the	DT
cord-005081-kxrzv16n	280	6	scale	scale	NN
cord-005081-kxrzv16n	280	7	of	of	IN
cord-005081-kxrzv16n	280	8	mortality	mortality	NN
cord-005081-kxrzv16n	280	9	due	due	IN
cord-005081-kxrzv16n	280	10	to	to	IN
cord-005081-kxrzv16n	280	11	the	the	DT
cord-005081-kxrzv16n	280	12	H1N1sw1	H1N1sw1	NNP
cord-005081-kxrzv16n	280	13	pandemic	pandemic	NN
cord-005081-kxrzv16n	280	14	are	be	VBP
cord-005081-kxrzv16n	280	15	held	hold	VBN
cord-005081-kxrzv16n	280	16	with	with	IN
cord-005081-kxrzv16n	280	17	not	not	RB
cord-005081-kxrzv16n	280	18	quite	quite	RB
cord-005081-kxrzv16n	280	19	correct	correct	JJ
cord-005081-kxrzv16n	280	20	argumentation	argumentation	NN
cord-005081-kxrzv16n	280	21	.	.	.
cord-005081-kxrzv16n	281	1	Even	even	RB
cord-005081-kxrzv16n	281	2	without	without	IN
cord-005081-kxrzv16n	281	3	very	very	RB
cord-005081-kxrzv16n	281	4	strict	strict	JJ
cord-005081-kxrzv16n	281	5	crite	crite	FW
cord-005081-kxrzv16n	281	6	ria	ria	NNP
cord-005081-kxrzv16n	281	7	,	,	,
cord-005081-kxrzv16n	281	8	it	-PRON-	PRP
cord-005081-kxrzv16n	281	9	is	be	VBZ
cord-005081-kxrzv16n	281	10	an	an	DT
cord-005081-kxrzv16n	281	11	emergency	emergency	NN
cord-005081-kxrzv16n	281	12	when	when	WRB
cord-005081-kxrzv16n	281	13	a	a	DT
cord-005081-kxrzv16n	281	14	healthy	healthy	JJ
cord-005081-kxrzv16n	281	15	young	young	JJ
cord-005081-kxrzv16n	281	16	or	or	CC
cord-005081-kxrzv16n	281	17	mid	mid	JJ
cord-005081-kxrzv16n	281	18	dle	dle	NNP
cord-005081-kxrzv16n	281	19	aged	aged	JJ
cord-005081-kxrzv16n	281	20	person	person	NN
cord-005081-kxrzv16n	281	21	dies	die	VBZ
cord-005081-kxrzv16n	281	22	from	from	IN
cord-005081-kxrzv16n	281	23	influenza	influenza	NN
cord-005081-kxrzv16n	281	24	.	.	.
cord-005081-kxrzv16n	282	1	Vaccination	vaccination	NN
cord-005081-kxrzv16n	282	2	and	and	CC
cord-005081-kxrzv16n	282	3	timely	timely	JJ
cord-005081-kxrzv16n	282	4	administration	administration	NN
cord-005081-kxrzv16n	282	5	of	of	IN
cord-005081-kxrzv16n	282	6	efficacious	efficacious	NNP
cord-005081-kxrzv16n	282	7	antiinfluenza	antiinfluenza	NNP
cord-005081-kxrzv16n	282	8	means	mean	NNS
cord-005081-kxrzv16n	282	9	,	,	,
cord-005081-kxrzv16n	282	10	within	within	IN
cord-005081-kxrzv16n	282	11	a	a	DT
cord-005081-kxrzv16n	282	12	complex	complex	JJ
cord-005081-kxrzv16n	282	13	antiinfluenza	antiinfluenza	NNP
cord-005081-kxrzv16n	282	14	therapy	therapy	NN
cord-005081-kxrzv16n	282	15	,	,	,
cord-005081-kxrzv16n	282	16	offer	offer	VBP
cord-005081-kxrzv16n	282	17	good	good	JJ
cord-005081-kxrzv16n	282	18	chances	chance	NNS
cord-005081-kxrzv16n	282	19	to	to	TO
cord-005081-kxrzv16n	282	20	avoid	avoid	VB
cord-005081-kxrzv16n	282	21	,	,	,
cord-005081-kxrzv16n	282	22	in	in	IN
cord-005081-kxrzv16n	282	23	an	an	DT
cord-005081-kxrzv16n	282	24	overwhelming	overwhelming	JJ
cord-005081-kxrzv16n	282	25	majority	majority	NN
cord-005081-kxrzv16n	282	26	of	of	IN
cord-005081-kxrzv16n	282	27	cases	case	NNS
cord-005081-kxrzv16n	282	28	,	,	,
cord-005081-kxrzv16n	282	29	severe	severe	JJ
cord-005081-kxrzv16n	282	30	complications	complication	NNS
cord-005081-kxrzv16n	282	31	and	and	CC
cord-005081-kxrzv16n	282	32	,	,	,
cord-005081-kxrzv16n	282	33	certainly	certainly	RB
cord-005081-kxrzv16n	282	34	,	,	,
cord-005081-kxrzv16n	282	35	a	a	DT
cord-005081-kxrzv16n	282	36	lethal	lethal	JJ
cord-005081-kxrzv16n	282	37	outcome	outcome	NN
cord-005081-kxrzv16n	282	38	.	.	.
cord-005081-kxrzv16n	283	1	According	accord	VBG
cord-005081-kxrzv16n	283	2	to	to	IN
cord-005081-kxrzv16n	283	3	the	the	DT
cord-005081-kxrzv16n	283	4	latest	late	JJS
cord-005081-kxrzv16n	283	5	statistics	statistic	NNS
cord-005081-kxrzv16n	283	6	,	,	,
cord-005081-kxrzv16n	283	7	the	the	DT
cord-005081-kxrzv16n	283	8	H1N1sw1	H1N1sw1	NNP
cord-005081-kxrzv16n	283	9	related	related	JJ
cord-005081-kxrzv16n	283	10	mortality	mortality	NN
cord-005081-kxrzv16n	283	11	rate	rate	NN
cord-005081-kxrzv16n	283	12	is	be	VBZ
cord-005081-kxrzv16n	283	13	reliably	reliably	RB
cord-005081-kxrzv16n	283	14	higher	high	JJR
cord-005081-kxrzv16n	283	15	than	than	IN
cord-005081-kxrzv16n	283	16	the	the	DT
cord-005081-kxrzv16n	283	17	share	share	NN
cord-005081-kxrzv16n	283	18	of	of	IN
cord-005081-kxrzv16n	283	19	lethal	lethal	JJ
cord-005081-kxrzv16n	283	20	outcomes	outcome	NNS
cord-005081-kxrzv16n	283	21	in	in	IN
cord-005081-kxrzv16n	283	22	the	the	DT
cord-005081-kxrzv16n	283	23	1968	1968	CD
cord-005081-kxrzv16n	283	24	-	-	SYM
cord-005081-kxrzv16n	283	25	1969	1969	CD
cord-005081-kxrzv16n	283	26	pan	pan	NNP
cord-005081-kxrzv16n	283	27	demic	demic	NNP
cord-005081-kxrzv16n	283	28	,	,	,
cord-005081-kxrzv16n	283	29	while	while	IN
cord-005081-kxrzv16n	283	30	lower	low	JJR
cord-005081-kxrzv16n	283	31	than	than	IN
cord-005081-kxrzv16n	283	32	during	during	IN
cord-005081-kxrzv16n	283	33	the	the	DT
cord-005081-kxrzv16n	283	34	1957	1957	CD
cord-005081-kxrzv16n	283	35	Asiatic	asiatic	JJ
cord-005081-kxrzv16n	283	36	influ	influ	NNP
cord-005081-kxrzv16n	283	37	enza	enza	NNP
cord-005081-kxrzv16n	283	38	.	.	.
cord-005081-kxrzv16n	284	1	Of	of	RB
cord-005081-kxrzv16n	284	2	course	course	RB
cord-005081-kxrzv16n	284	3	,	,	,
cord-005081-kxrzv16n	284	4	medical	medical	JJ
cord-005081-kxrzv16n	284	5	science	science	NN
cord-005081-kxrzv16n	284	6	has	have	VBZ
cord-005081-kxrzv16n	284	7	made	make	VBN
cord-005081-kxrzv16n	284	8	a	a	DT
cord-005081-kxrzv16n	284	9	signifi	signifi	NN
cord-005081-kxrzv16n	284	10	ca	can	MD
cord-005081-kxrzv16n	284	11	nt	not	RB
cord-005081-kxrzv16n	284	12	progress	progress	VB
cord-005081-kxrzv16n	284	13	since	since	IN
cord-005081-kxrzv16n	284	14	1957	1957	CD
cord-005081-kxrzv16n	284	15	,	,	,
cord-005081-kxrzv16n	284	16	continuously	continuously	RB
cord-005081-kxrzv16n	284	17	introducing	introduce	VBG
cord-005081-kxrzv16n	284	18	from	from	IN
cord-005081-kxrzv16n	284	19	1968	1968	CD
cord-005081-kxrzv16n	284	20	antiviral	antiviral	JJ
cord-005081-kxrzv16n	284	21	therapeutic	therapeutic	JJ
cord-005081-kxrzv16n	284	22	means	mean	NNS
cord-005081-kxrzv16n	284	23	into	into	IN
cord-005081-kxrzv16n	284	24	clinical	clinical	JJ
cord-005081-kxrzv16n	284	25	practice	practice	NN
cord-005081-kxrzv16n	284	26	.	.	.
cord-005081-kxrzv16n	285	1	Based	base	VBN
cord-005081-kxrzv16n	285	2	on	on	IN
cord-005081-kxrzv16n	285	3	the	the	DT
cord-005081-kxrzv16n	285	4	above	above	JJ
cord-005081-kxrzv16n	285	5	,	,	,
cord-005081-kxrzv16n	285	6	we	-PRON-	PRP
cord-005081-kxrzv16n	285	7	have	have	VBP
cord-005081-kxrzv16n	285	8	to	to	TO
cord-005081-kxrzv16n	285	9	draw	draw	VB
cord-005081-kxrzv16n	285	10	the	the	DT
cord-005081-kxrzv16n	285	11	fol	fol	NN
cord-005081-kxrzv16n	285	12	lowing	low	VBG
cord-005081-kxrzv16n	285	13	not	not	RB
cord-005081-kxrzv16n	285	14	very	very	RB
cord-005081-kxrzv16n	285	15	comfortable	comfortable	JJ
cord-005081-kxrzv16n	285	16	conclusion	conclusion	NN
cord-005081-kxrzv16n	285	17	:	:	:
cord-005081-kxrzv16n	285	18	high	high	JJ
cord-005081-kxrzv16n	285	19	influ	influ	NNP
cord-005081-kxrzv16n	285	20	enza	enza	NNP
cord-005081-kxrzv16n	285	21	related	related	JJ
cord-005081-kxrzv16n	285	22	mortality	mortality	NN
cord-005081-kxrzv16n	285	23	rates	rate	NNS
cord-005081-kxrzv16n	285	24	are	be	VBP
cord-005081-kxrzv16n	285	25	,	,	,
cord-005081-kxrzv16n	285	26	to	to	IN
cord-005081-kxrzv16n	285	27	a	a	DT
cord-005081-kxrzv16n	285	28	considerable	considerable	JJ
cord-005081-kxrzv16n	285	29	degree	degree	NN
cord-005081-kxrzv16n	285	30	,	,	,
cord-005081-kxrzv16n	285	31	explained	explain	VBN
cord-005081-kxrzv16n	285	32	by	by	IN
cord-005081-kxrzv16n	285	33	our	-PRON-	PRP$
cord-005081-kxrzv16n	285	34	poor	poor	JJ
cord-005081-kxrzv16n	285	35	performance	performance	NN
cord-005081-kxrzv16n	285	36	in	in	IN
cord-005081-kxrzv16n	285	37	orga	orga	NNP
cord-005081-kxrzv16n	285	38	nizing	nizing	NNP
cord-005081-kxrzv16n	285	39	medical	medical	JJ
cord-005081-kxrzv16n	285	40	aid	aid	NN
cord-005081-kxrzv16n	285	41	to	to	IN
cord-005081-kxrzv16n	285	42	patients	patient	NNS
cord-005081-kxrzv16n	285	43	.	.	.
cord-005081-kxrzv16n	286	1	Russia	Russia	NNP
cord-005081-kxrzv16n	286	2	is	be	VBZ
cord-005081-kxrzv16n	286	3	also	also	RB
cord-005081-kxrzv16n	286	4	no	no	DT
cord-005081-kxrzv16n	286	5	exclu	exclu	JJ
cord-005081-kxrzv16n	286	6	sion	sion	NN
cord-005081-kxrzv16n	286	7	in	in	IN
cord-005081-kxrzv16n	286	8	this	this	DT
cord-005081-kxrzv16n	286	9	aspect	aspect	NN
cord-005081-kxrzv16n	286	10	.	.	.
cord-005081-kxrzv16n	287	1	At	at	IN
cord-005081-kxrzv16n	287	2	the	the	DT
cord-005081-kxrzv16n	287	3	same	same	JJ
cord-005081-kxrzv16n	287	4	time	time	NN
cord-005081-kxrzv16n	287	5	,	,	,
cord-005081-kxrzv16n	287	6	availability	availability	NN
cord-005081-kxrzv16n	287	7	of	of	IN
cord-005081-kxrzv16n	287	8	developed	develop	VBN
cord-005081-kxrzv16n	287	9	facilities	facility	NNS
cord-005081-kxrzv16n	287	10	for	for	IN
cord-005081-kxrzv16n	287	11	producing	produce	VBG
cord-005081-kxrzv16n	287	12	influenza	influenza	NN
cord-005081-kxrzv16n	287	13	vaccines	vaccine	NNS
cord-005081-kxrzv16n	287	14	allows	allow	VBZ
cord-005081-kxrzv16n	287	15	Russia	Russia	NNP
cord-005081-kxrzv16n	287	16	,	,	,
cord-005081-kxrzv16n	287	17	in	in	IN
cord-005081-kxrzv16n	287	18	contrast	contrast	NN
cord-005081-kxrzv16n	287	19	to	to	IN
cord-005081-kxrzv16n	287	20	other	other	JJ
cord-005081-kxrzv16n	287	21	countries	country	NNS
cord-005081-kxrzv16n	287	22	,	,	,
cord-005081-kxrzv16n	287	23	to	to	TO
cord-005081-kxrzv16n	287	24	promptly	promptly	RB
cord-005081-kxrzv16n	287	25	take	take	VB
cord-005081-kxrzv16n	287	26	decisions	decision	NNS
cord-005081-kxrzv16n	287	27	on	on	IN
cord-005081-kxrzv16n	287	28	a	a	DT
cord-005081-kxrzv16n	287	29	national	national	JJ
cord-005081-kxrzv16n	287	30	vaccination	vaccination	NN
cord-005081-kxrzv16n	287	31	pro	pro	JJ
cord-005081-kxrzv16n	287	32	gram	gram	NN
cord-005081-kxrzv16n	287	33	of	of	IN
cord-005081-kxrzv16n	287	34	scale	scale	NN
cord-005081-kxrzv16n	287	35	.	.	.
cord-005081-kxrzv16n	288	1	Returning	return	VBG
cord-005081-kxrzv16n	288	2	to	to	IN
cord-005081-kxrzv16n	288	3	the	the	DT
cord-005081-kxrzv16n	288	4	problem	problem	NN
cord-005081-kxrzv16n	288	5	of	of	IN
cord-005081-kxrzv16n	288	6	genetic	genetic	JJ
cord-005081-kxrzv16n	288	7	properties	property	NNS
cord-005081-kxrzv16n	288	8	of	of	IN
cord-005081-kxrzv16n	288	9	pandemic	pandemic	NN
cord-005081-kxrzv16n	288	10	viruses	virus	NNS
cord-005081-kxrzv16n	288	11	and	and	CC
cord-005081-kxrzv16n	288	12	the	the	DT
cord-005081-kxrzv16n	288	13	discussion	discussion	NN
cord-005081-kxrzv16n	288	14	about	about	IN
cord-005081-kxrzv16n	288	15	the	the	DT
cord-005081-kxrzv16n	288	16	molec	molec	JJ
cord-005081-kxrzv16n	288	17	ular	ular	JJ
cord-005081-kxrzv16n	288	18	determinants	determinant	NNS
cord-005081-kxrzv16n	288	19	of	of	IN
cord-005081-kxrzv16n	288	20	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	288	21	,	,	,
cord-005081-kxrzv16n	288	22	we	-PRON-	PRP
cord-005081-kxrzv16n	288	23	have	have	VBP
cord-005081-kxrzv16n	288	24	to	to	TO
cord-005081-kxrzv16n	288	25	repeat	repeat	VB
cord-005081-kxrzv16n	288	26	that	that	IN
cord-005081-kxrzv16n	288	27	the	the	DT
cord-005081-kxrzv16n	288	28	2009	2009	CD
cord-005081-kxrzv16n	288	29	influenza	influenza	NN
cord-005081-kxrzv16n	288	30	pandemic	pandemic	NN
cord-005081-kxrzv16n	288	31	was	be	VBD
cord-005081-kxrzv16n	288	32	caused	cause	VBN
cord-005081-kxrzv16n	288	33	by	by	IN
cord-005081-kxrzv16n	288	34	the	the	DT
cord-005081-kxrzv16n	288	35	mixed	mixed	JJ
cord-005081-kxrzv16n	288	36	H1N1v	h1n1v	CD
cord-005081-kxrzv16n	288	37	2009	2009	CD
cord-005081-kxrzv16n	288	38	virus	virus	NN
cord-005081-kxrzv16n	288	39	with	with	IN
cord-005081-kxrzv16n	288	40	a	a	DT
cord-005081-kxrzv16n	288	41	genome	genome	NN
cord-005081-kxrzv16n	288	42	that	that	WDT
cord-005081-kxrzv16n	288	43	included	include	VBD
cord-005081-kxrzv16n	288	44	genes	gene	NNS
cord-005081-kxrzv16n	288	45	of	of	IN
cord-005081-kxrzv16n	288	46	swine	swine	NN
cord-005081-kxrzv16n	288	47	,	,	,
cord-005081-kxrzv16n	288	48	avian	avian	JJ
cord-005081-kxrzv16n	288	49	,	,	,
cord-005081-kxrzv16n	288	50	and	and	CC
cord-005081-kxrzv16n	288	51	human	human	JJ
cord-005081-kxrzv16n	288	52	viruses	virus	NNS
cord-005081-kxrzv16n	288	53	.	.	.
cord-005081-kxrzv16n	289	1	Based	base	VBN
cord-005081-kxrzv16n	289	2	on	on	IN
cord-005081-kxrzv16n	289	3	the	the	DT
cord-005081-kxrzv16n	289	4	specific	specific	JJ
cord-005081-kxrzv16n	289	5	structure	structure	NN
cord-005081-kxrzv16n	289	6	of	of	IN
cord-005081-kxrzv16n	289	7	its	-PRON-	PRP$
cord-005081-kxrzv16n	289	8	genome	genome	NN
cord-005081-kxrzv16n	289	9	and	and	CC
cord-005081-kxrzv16n	289	10	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	289	11	level	level	NN
cord-005081-kxrzv16n	289	12	in	in	IN
cord-005081-kxrzv16n	289	13	animals	animal	NNS
cord-005081-kxrzv16n	289	14	(	(	-LRB-
cord-005081-kxrzv16n	289	15	experimental	experimental	JJ
cord-005081-kxrzv16n	289	16	models	model	NNS
cord-005081-kxrzv16n	289	17	)	)	-RRB-
cord-005081-kxrzv16n	289	18	and	and	CC
cord-005081-kxrzv16n	289	19	humans	human	NNS
cord-005081-kxrzv16n	289	20	,	,	,
cord-005081-kxrzv16n	289	21	we	-PRON-	PRP
cord-005081-kxrzv16n	289	22	can	can	MD
cord-005081-kxrzv16n	289	23	characterize	characterize	VB
cord-005081-kxrzv16n	289	24	this	this	DT
cord-005081-kxrzv16n	289	25	etiological	etiological	JJ
cord-005081-kxrzv16n	289	26	agent	agent	NN
cord-005081-kxrzv16n	289	27	as	as	IN
cord-005081-kxrzv16n	289	28	a	a	DT
cord-005081-kxrzv16n	289	29	moder	moder	NNP
cord-005081-kxrzv16n	289	30	ately	ately	RB
cord-005081-kxrzv16n	289	31	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	289	32	virus	virus	NN
cord-005081-kxrzv16n	289	33	.	.	.
cord-005081-kxrzv16n	290	1	In	in	IN
cord-005081-kxrzv16n	290	2	particular	particular	JJ
cord-005081-kxrzv16n	290	3	,	,	,
cord-005081-kxrzv16n	290	4	HA	HA	NNP
cord-005081-kxrzv16n	290	5	of	of	IN
cord-005081-kxrzv16n	290	6	the	the	DT
cord-005081-kxrzv16n	290	7	H1N1v	H1N1v	NNP
cord-005081-kxrzv16n	290	8	2009	2009	CD
cord-005081-kxrzv16n	290	9	virus	virus	NN
cord-005081-kxrzv16n	290	10	does	do	VBZ
cord-005081-kxrzv16n	290	11	not	not	RB
cord-005081-kxrzv16n	290	12	contain	contain	VB
cord-005081-kxrzv16n	290	13	the	the	DT
cord-005081-kxrzv16n	290	14	proteolysis	proteolysis	NN
cord-005081-kxrzv16n	290	15	sites	site	NNS
cord-005081-kxrzv16n	290	16	characterizing	characterize	VBG
cord-005081-kxrzv16n	290	17	the	the	DT
cord-005081-kxrzv16n	290	18	highly	highly	RB
cord-005081-kxrzv16n	290	19	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	290	20	H5N1	H5N1	NNP
cord-005081-kxrzv16n	290	21	viruses	virus	NNS
cord-005081-kxrzv16n	290	22	.	.	.
cord-005081-kxrzv16n	291	1	The	the	DT
cord-005081-kxrzv16n	291	2	PB1	pb1	NN
cord-005081-kxrzv16n	291	3	F2	F2	NNP
cord-005081-kxrzv16n	291	4	reading	reading	NN
cord-005081-kxrzv16n	291	5	frame	frame	NN
cord-005081-kxrzv16n	291	6	in	in	IN
cord-005081-kxrzv16n	291	7	the	the	DT
cord-005081-kxrzv16n	291	8	genome	genome	NN
cord-005081-kxrzv16n	291	9	's	's	POS
cord-005081-kxrzv16n	291	10	second	second	JJ
cord-005081-kxrzv16n	291	11	fragment	fragment	NN
cord-005081-kxrzv16n	292	1	(	(	-LRB-
cord-005081-kxrzv16n	292	2	encoding	encode	VBG
cord-005081-kxrzv16n	292	3	the	the	DT
cord-005081-kxrzv16n	292	4	PB1	PB1	NNP
cord-005081-kxrzv16n	292	5	protein	protein	NN
cord-005081-kxrzv16n	292	6	and	and	CC
cord-005081-kxrzv16n	292	7	the	the	DT
cord-005081-kxrzv16n	292	8	supplementary	supplementary	JJ
cord-005081-kxrzv16n	292	9	PB1	PB1	NNP
cord-005081-kxrzv16n	292	10	F2	F2	NNP
cord-005081-kxrzv16n	292	11	protein	protein	NN
cord-005081-kxrzv16n	292	12	resembling	resemble	VBG
cord-005081-kxrzv16n	292	13	bacterial	bacterial	JJ
cord-005081-kxrzv16n	292	14	toxins	toxin	NNS
cord-005081-kxrzv16n	292	15	by	by	IN
cord-005081-kxrzv16n	292	16	structure	structure	NN
cord-005081-kxrzv16n	292	17	)	)	-RRB-
cord-005081-kxrzv16n	292	18	is	be	VBZ
cord-005081-kxrzv16n	292	19	three	three	CD
cord-005081-kxrzv16n	292	20	times	time	NNS
cord-005081-kxrzv16n	292	21	interrupted	interrupt	VBN
cord-005081-kxrzv16n	292	22	by	by	IN
cord-005081-kxrzv16n	292	23	stop	stop	NN
cord-005081-kxrzv16n	292	24	codons	codon	NNS
cord-005081-kxrzv16n	292	25	,	,	,
cord-005081-kxrzv16n	292	26	which	which	WDT
cord-005081-kxrzv16n	292	27	leads	lead	VBZ
cord-005081-kxrzv16n	292	28	to	to	IN
cord-005081-kxrzv16n	292	29	the	the	DT
cord-005081-kxrzv16n	292	30	absence	absence	NN
cord-005081-kxrzv16n	292	31	of	of	IN
cord-005081-kxrzv16n	292	32	protein	protein	NN
cord-005081-kxrzv16n	292	33	synthe	synthe	NNP
cord-005081-kxrzv16n	292	34	sis	sis	NN
cord-005081-kxrzv16n	292	35	in	in	IN
cord-005081-kxrzv16n	292	36	the	the	DT
cord-005081-kxrzv16n	292	37	infected	infected	JJ
cord-005081-kxrzv16n	292	38	cells	cell	NNS
cord-005081-kxrzv16n	292	39	.	.	.
cord-005081-kxrzv16n	293	1	The	the	DT
cord-005081-kxrzv16n	293	2	absence	absence	NN
cord-005081-kxrzv16n	293	3	of	of	IN
cord-005081-kxrzv16n	293	4	PB1	PB1	NNP
cord-005081-kxrzv16n	293	5	F2	F2	NNP
cord-005081-kxrzv16n	293	6	,	,	,
cord-005081-kxrzv16n	293	7	as	as	IN
cord-005081-kxrzv16n	293	8	the	the	DT
cord-005081-kxrzv16n	293	9	most	most	RBS
cord-005081-kxrzv16n	293	10	important	important	JJ
cord-005081-kxrzv16n	293	11	factor	factor	NN
cord-005081-kxrzv16n	293	12	of	of	IN
cord-005081-kxrzv16n	293	13	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	293	14	,	,	,
cord-005081-kxrzv16n	293	15	in	in	IN
cord-005081-kxrzv16n	293	16	the	the	DT
cord-005081-kxrzv16n	293	17	influ	influ	NNP
cord-005081-kxrzv16n	293	18	enza	enza	NNP
cord-005081-kxrzv16n	294	1	A	a	DT
cord-005081-kxrzv16n	294	2	viruses	virus	NNS
cord-005081-kxrzv16n	294	3	is	be	VBZ
cord-005081-kxrzv16n	294	4	an	an	DT
cord-005081-kxrzv16n	294	5	additional	additional	JJ
cord-005081-kxrzv16n	294	6	argument	argument	NN
cord-005081-kxrzv16n	294	7	in	in	IN
cord-005081-kxrzv16n	294	8	support	support	NN
cord-005081-kxrzv16n	294	9	of	of	IN
cord-005081-kxrzv16n	294	10	specifying	specify	VBG
cord-005081-kxrzv16n	294	11	this	this	DT
cord-005081-kxrzv16n	294	12	virus	virus	NN
cord-005081-kxrzv16n	294	13	as	as	IN
cord-005081-kxrzv16n	294	14	moderately	moderately	RB
cord-005081-kxrzv16n	294	15	pathogenic	pathogenic	JJ
cord-005081-kxrzv16n	294	16	.	.	.
cord-005081-kxrzv16n	295	1	In	in	IN
cord-005081-kxrzv16n	295	2	addition	addition	NN
cord-005081-kxrzv16n	295	3	,	,	,
cord-005081-kxrzv16n	295	4	this	this	DT
cord-005081-kxrzv16n	295	5	very	very	RB
cord-005081-kxrzv16n	295	6	genetic	genetic	JJ
cord-005081-kxrzv16n	295	7	sign	sign	NN
cord-005081-kxrzv16n	295	8	is	be	VBZ
cord-005081-kxrzv16n	295	9	a	a	DT
cord-005081-kxrzv16n	295	10	principal	principal	JJ
cord-005081-kxrzv16n	295	11	difference	difference	NN
cord-005081-kxrzv16n	295	12	of	of	IN
cord-005081-kxrzv16n	295	13	the	the	DT
cord-005081-kxrzv16n	295	14	current	current	JJ
cord-005081-kxrzv16n	295	15	pandemic	pandemic	NN
cord-005081-kxrzv16n	295	16	H1N1v	h1n1v	CD
cord-005081-kxrzv16n	296	1	2009	2009	CD
cord-005081-kxrzv16n	296	2	virus	virus	NN
cord-005081-kxrzv16n	296	3	from	from	IN
cord-005081-kxrzv16n	296	4	the	the	DT
cord-005081-kxrzv16n	296	5	1918	1918	CD
cord-005081-kxrzv16n	296	6	H1N1	H1N1	NNP
cord-005081-kxrzv16n	296	7	virus	virus	NN
cord-005081-kxrzv16n	296	8	that	that	WDT
cord-005081-kxrzv16n	296	9	caused	cause	VBD
cord-005081-kxrzv16n	296	10	the	the	DT
cord-005081-kxrzv16n	296	11	Hispanic	hispanic	JJ
cord-005081-kxrzv16n	296	12	influenza	influenza	NN
cord-005081-kxrzv16n	296	13	pandemic	pandemic	NN
cord-005081-kxrzv16n	296	14	.	.	.
cord-005081-kxrzv16n	297	1	Moreover	moreover	RB
cord-005081-kxrzv16n	297	2	,	,	,
cord-005081-kxrzv16n	297	3	the	the	DT
cord-005081-kxrzv16n	297	4	pandemic	pandemic	NN
cord-005081-kxrzv16n	297	5	H1N1v	h1n1v	CD
cord-005081-kxrzv16n	297	6	2009	2009	CD
cord-005081-kxrzv16n	297	7	virus	virus	NN
cord-005081-kxrzv16n	297	8	is	be	VBZ
cord-005081-kxrzv16n	297	9	defi	defi	NNP
cord-005081-kxrzv16n	297	10	cient	cient	NNP
cord-005081-kxrzv16n	297	11	in	in	IN
cord-005081-kxrzv16n	297	12	the	the	DT
cord-005081-kxrzv16n	297	13	NS1	ns1	NN
cord-005081-kxrzv16n	297	14	protein	protein	NN
cord-005081-kxrzv16n	297	15	,	,	,
cord-005081-kxrzv16n	297	16	the	the	DT
cord-005081-kxrzv16n	297	17	antagonist	antagonist	NN
cord-005081-kxrzv16n	297	18	of	of	IN
cord-005081-kxrzv16n	297	19	I	I	NNP
cord-005081-kxrzv16n	297	20	and	and	CC
cord-005081-kxrzv16n	297	21	II	ii	CD
cord-005081-kxrzv16n	297	22	types	type	NNS
cord-005081-kxrzv16n	297	23	interferons	interferon	NNS
cord-005081-kxrzv16n	297	24	.	.	.
cord-005081-kxrzv16n	298	1	In	in	IN
cord-005081-kxrzv16n	298	2	the	the	DT
cord-005081-kxrzv16n	298	3	NS1	ns1	NN
cord-005081-kxrzv16n	298	4	protein	protein	NN
cord-005081-kxrzv16n	298	5	from	from	IN
cord-005081-kxrzv16n	298	6	North	North	NNP
cord-005081-kxrzv16n	298	7	America	America	NNP
cord-005081-kxrzv16n	298	8	and	and	CC
cord-005081-kxrzv16n	298	9	the	the	DT
cord-005081-kxrzv16n	298	10	Russian	Russian	NNP
cord-005081-kxrzv16n	298	11	Federation	Federation	NNP
cord-005081-kxrzv16n	298	12	's	's	POS
cord-005081-kxrzv16n	298	13	isolates	isolate	NNS
cord-005081-kxrzv16n	298	14	,	,	,
cord-005081-kxrzv16n	298	15	researchers	researcher	NNS
cord-005081-kxrzv16n	298	16	have	have	VBP
cord-005081-kxrzv16n	298	17	found	find	VBN
cord-005081-kxrzv16n	298	18	C	C	NNP
cord-005081-kxrzv16n	298	19	terminal	terminal	NN
cord-005081-kxrzv16n	298	20	deletion	deletion	NN
cord-005081-kxrzv16n	298	21	of	of	IN
cord-005081-kxrzv16n	298	22	an	an	DT
cord-005081-kxrzv16n	298	23	important	important	JJ
cord-005081-kxrzv16n	298	24	regulatory	regulatory	JJ
cord-005081-kxrzv16n	298	25	site	site	NN
cord-005081-kxrzv16n	298	26	playing	play	VBG
cord-005081-kxrzv16n	298	27	a	a	DT
cord-005081-kxrzv16n	298	28	key	key	JJ
cord-005081-kxrzv16n	298	29	role	role	NN
cord-005081-kxrzv16n	298	30	in	in	IN
cord-005081-kxrzv16n	298	31	the	the	DT
cord-005081-kxrzv16n	298	32	acti	acti	NNP
cord-005081-kxrzv16n	298	33	vation	vation	NN
cord-005081-kxrzv16n	298	34	of	of	IN
cord-005081-kxrzv16n	298	35	the	the	DT
cord-005081-kxrzv16n	298	36	signaling	signal	VBG
cord-005081-kxrzv16n	298	37	cell	cell	NN
cord-005081-kxrzv16n	298	38	systems	system	NNS
cord-005081-kxrzv16n	298	39	controlling	control	VBG
cord-005081-kxrzv16n	298	40	the	the	DT
cord-005081-kxrzv16n	298	41	antiviral	antiviral	JJ
cord-005081-kxrzv16n	298	42	response	response	NN
cord-005081-kxrzv16n	298	43	of	of	IN
cord-005081-kxrzv16n	298	44	the	the	DT
cord-005081-kxrzv16n	298	45	body	body	NN
cord-005081-kxrzv16n	298	46	's	's	POS
cord-005081-kxrzv16n	298	47	cells	cell	NNS
cord-005081-kxrzv16n	298	48	(	(	-LRB-
cord-005081-kxrzv16n	298	49	the	the	DT
cord-005081-kxrzv16n	298	50	deletion	deletion	NN
cord-005081-kxrzv16n	298	51	of	of	IN
cord-005081-kxrzv16n	298	52	so	so	RB
cord-005081-kxrzv16n	298	53	called	call	VBN
cord-005081-kxrzv16n	298	54	PDZ	PDZ	NNP
cord-005081-kxrzv16n	298	55	binding	bind	VBG
cord-005081-kxrzv16n	298	56	domain	domain	NN
cord-005081-kxrzv16n	298	57	)	)	-RRB-
cord-005081-kxrzv16n	298	58	in	in	IN
cord-005081-kxrzv16n	298	59	influenza	influenza	NN
cord-005081-kxrzv16n	298	60	infections	infection	NNS
cord-005081-kxrzv16n	298	61	.	.	.
cord-005081-kxrzv16n	299	1	This	this	DT
cord-005081-kxrzv16n	299	2	deletion	deletion	NN
cord-005081-kxrzv16n	299	3	is	be	VBZ
cord-005081-kxrzv16n	299	4	probably	probably	RB
cord-005081-kxrzv16n	299	5	related	relate	VBN
cord-005081-kxrzv16n	299	6	to	to	IN
cord-005081-kxrzv16n	299	7	the	the	DT
cord-005081-kxrzv16n	299	8	increased	increase	VBN
cord-005081-kxrzv16n	299	9	sen	sen	NNP
cord-005081-kxrzv16n	299	10	sitivity	sitivity	NN
cord-005081-kxrzv16n	299	11	of	of	IN
cord-005081-kxrzv16n	299	12	the	the	DT
cord-005081-kxrzv16n	299	13	pandemic	pandemic	NN
cord-005081-kxrzv16n	299	14	H1N1v	h1n1v	CD
cord-005081-kxrzv16n	300	1	2009	2009	CD
cord-005081-kxrzv16n	300	2	influenza	influenza	NN
cord-005081-kxrzv16n	300	3	to	to	IN
cord-005081-kxrzv16n	300	4	interferons	interferon	NNS
cord-005081-kxrzv16n	300	5	and	and	CC
cord-005081-kxrzv16n	300	6	,	,	,
cord-005081-kxrzv16n	300	7	in	in	IN
cord-005081-kxrzv16n	300	8	particular	particular	JJ
cord-005081-kxrzv16n	300	9	,	,	,
cord-005081-kxrzv16n	300	10	to	to	TO
cord-005081-kxrzv16n	300	11	gamma	gamma	VB
cord-005081-kxrzv16n	300	12	interferon	interferon	NN
cord-005081-kxrzv16n	300	13	.	.	.
cord-005081-kxrzv16n	301	1	Summarizing	summarize	VBG
cord-005081-kxrzv16n	301	2	the	the	DT
cord-005081-kxrzv16n	301	3	above	above	JJ
cord-005081-kxrzv16n	301	4	analysis	analysis	NN
cord-005081-kxrzv16n	301	5	of	of	IN
cord-005081-kxrzv16n	301	6	the	the	DT
cord-005081-kxrzv16n	301	7	functional	functional	JJ
cord-005081-kxrzv16n	301	8	domains	domain	NNS
cord-005081-kxrzv16n	301	9	of	of	IN
cord-005081-kxrzv16n	301	10	the	the	DT
cord-005081-kxrzv16n	301	11	H1N1v	H1N1v	NNP
cord-005081-kxrzv16n	301	12	influenza	influenza	NN
cord-005081-kxrzv16n	301	13	virus	virus	NN
cord-005081-kxrzv16n	301	14	protein	protein	NN
cord-005081-kxrzv16n	301	15	,	,	,
cord-005081-kxrzv16n	301	16	we	-PRON-	PRP
cord-005081-kxrzv16n	301	17	have	have	VBP
cord-005081-kxrzv16n	301	18	to	to	TO
cord-005081-kxrzv16n	301	19	state	state	VB
cord-005081-kxrzv16n	301	20	that	that	IN
cord-005081-kxrzv16n	301	21	the	the	DT
cord-005081-kxrzv16n	301	22	current	current	JJ
cord-005081-kxrzv16n	301	23	pandemic	pandemic	NN
cord-005081-kxrzv16n	301	24	influenza	influenza	NN
cord-005081-kxrzv16n	301	25	viruses	virus	NNS
cord-005081-kxrzv16n	301	26	are	be	VBP
cord-005081-kxrzv16n	301	27	characterized	characterize	VBN
cord-005081-kxrzv16n	301	28	by	by	IN
cord-005081-kxrzv16n	301	29	the	the	DT
cord-005081-kxrzv16n	301	30	following	follow	VBG
cord-005081-kxrzv16n	301	31	structural	structural	JJ
cord-005081-kxrzv16n	301	32	defects	defect	NNS
cord-005081-kxrzv16n	301	33	:	:	:
cord-005081-kxrzv16n	301	34	the	the	DT
cord-005081-kxrzv16n	301	35	HA	HA	NNP
cord-005081-kxrzv16n	301	36	proteolysis	proteolysis	NN
cord-005081-kxrzv16n	301	37	site	site	NN
cord-005081-kxrzv16n	301	38	-	-	:
cord-005081-kxrzv16n	301	39	PSIQSR	PSIQSR	NNP
cord-005081-kxrzv16n	301	40	/	/	SYM
cord-005081-kxrzv16n	301	41	GLF	GLF	NNP
cord-005081-kxrzv16n	301	42	GAI	GAI	NNP
cord-005081-kxrzv16n	301	43	-	-	:
cord-005081-kxrzv16n	301	44	is	be	VBZ
cord-005081-kxrzv16n	301	45	a	a	DT
cord-005081-kxrzv16n	301	46	substrate	substrate	NN
cord-005081-kxrzv16n	301	47	for	for	IN
cord-005081-kxrzv16n	301	48	the	the	DT
cord-005081-kxrzv16n	301	49	membrane	membrane	NN
cord-005081-kxrzv16n	301	50	type	type	NN
cord-005081-kxrzv16n	301	51	serin	serin	FW
cord-005081-kxrzv16n	301	52	pro	pro	JJ
cord-005081-kxrzv16n	301	53	tease	tease	NN
cord-005081-kxrzv16n	301	54	TMP	TMP	NNP
cord-005081-kxrzv16n	301	55	/	/	SYM
cord-005081-kxrzv16n	301	56	SST	SST	NNP
cord-005081-kxrzv16n	301	57	,	,	,
cord-005081-kxrzv16n	301	58	the	the	DT
cord-005081-kxrzv16n	301	59	presence	presence	NN
cord-005081-kxrzv16n	301	60	of	of	IN
cord-005081-kxrzv16n	301	61	the	the	DT
cord-005081-kxrzv16n	301	62	three	three	CD
cord-005081-kxrzv16n	301	63	stop	stop	NN
cord-005081-kxrzv16n	301	64	codons	codon	NNS
cord-005081-kxrzv16n	301	65	in	in	IN
cord-005081-kxrzv16n	301	66	the	the	DT
cord-005081-kxrzv16n	301	67	PB1	pb1	JJ
cord-005081-kxrzv16n	301	68	F2	F2	NNP
cord-005081-kxrzv16n	301	69	protein	protein	NN
cord-005081-kxrzv16n	301	70	,	,	,
cord-005081-kxrzv16n	301	71	and	and	CC
cord-005081-kxrzv16n	301	72	the	the	DT
cord-005081-kxrzv16n	301	73	presence	presence	NN
cord-005081-kxrzv16n	301	74	of	of	IN
cord-005081-kxrzv16n	301	75	COOH	COOH	NNP
cord-005081-kxrzv16n	301	76	terminal	terminal	JJ
cord-005081-kxrzv16n	301	77	deletion	deletion	NN
cord-005081-kxrzv16n	301	78	of	of	IN
cord-005081-kxrzv16n	301	79	the	the	DT
cord-005081-kxrzv16n	301	80	PDZ	PDZ	NNP
cord-005081-kxrzv16n	301	81	binding	bind	VBG
cord-005081-kxrzv16n	301	82	domain	domain	NN
cord-005081-kxrzv16n	301	83	of	of	IN
cord-005081-kxrzv16n	301	84	NS1	ns1	NN
cord-005081-kxrzv16n	301	85	.	.	.
cord-005081-kxrzv16n	302	1	The	the	DT
cord-005081-kxrzv16n	302	2	above	above	JJ
cord-005081-kxrzv16n	302	3	genetic	genetic	JJ
cord-005081-kxrzv16n	302	4	defects	defect	NNS
cord-005081-kxrzv16n	302	5	of	of	IN
cord-005081-kxrzv16n	302	6	pandemic	pandemic	NN
cord-005081-kxrzv16n	302	7	viruses	virus	NNS
cord-005081-kxrzv16n	302	8	should	should	MD
cord-005081-kxrzv16n	302	9	additionally	additionally	RB
cord-005081-kxrzv16n	302	10	be	be	VB
cord-005081-kxrzv16n	302	11	characterized	characterize	VBN
cord-005081-kxrzv16n	302	12	by	by	IN
cord-005081-kxrzv16n	302	13	the	the	DT
cord-005081-kxrzv16n	302	14	following	follow	VBG
cord-005081-kxrzv16n	302	15	supplementary	supplementary	JJ
cord-005081-kxrzv16n	302	16	properties	property	NNS
cord-005081-kxrzv16n	302	17	:	:	:
cord-005081-kxrzv16n	302	18	(	(	-LRB-
cord-005081-kxrzv16n	302	19	1	1	LS
cord-005081-kxrzv16n	302	20	)	)	-RRB-
cord-005081-kxrzv16n	302	21	Resistance	resistance	NN
cord-005081-kxrzv16n	302	22	to	to	IN
cord-005081-kxrzv16n	302	23	the	the	DT
cord-005081-kxrzv16n	302	24	preparation	preparation	NN
cord-005081-kxrzv16n	302	25	Tamiflu	Tamiflu	NNP
cord-005081-kxrzv16n	302	26	,	,	,
cord-005081-kxrzv16n	302	27	which	which	WDT
cord-005081-kxrzv16n	302	28	is	be	VBZ
cord-005081-kxrzv16n	302	29	often	often	RB
cord-005081-kxrzv16n	302	30	manifested	manifest	VBN
cord-005081-kxrzv16n	302	31	by	by	IN
cord-005081-kxrzv16n	302	32	seasonal	seasonal	JJ
cord-005081-kxrzv16n	302	33	H1N1	H1N1	NNP
cord-005081-kxrzv16n	302	34	viruses	virus	NNS
cord-005081-kxrzv16n	302	35	and	and	CC
cord-005081-kxrzv16n	302	36	which	which	WDT
cord-005081-kxrzv16n	302	37	is	be	VBZ
cord-005081-kxrzv16n	302	38	characteristic	characteristic	JJ
cord-005081-kxrzv16n	302	39	of	of	IN
cord-005081-kxrzv16n	302	40	a	a	DT
cord-005081-kxrzv16n	302	41	pandemic	pandemic	NN
cord-005081-kxrzv16n	302	42	virus	virus	NN
cord-005081-kxrzv16n	302	43	.	.	.
cord-005081-kxrzv16n	303	1	(	(	-LRB-
cord-005081-kxrzv16n	303	2	2	2	LS
cord-005081-kxrzv16n	303	3	)	)	-RRB-
cord-005081-kxrzv16n	303	4	Cooperative	cooperative	JJ
cord-005081-kxrzv16n	303	5	specific	specific	JJ
cord-005081-kxrzv16n	303	6	properties	property	NNS
cord-005081-kxrzv16n	303	7	of	of	IN
cord-005081-kxrzv16n	303	8	the	the	DT
cord-005081-kxrzv16n	303	9	HA	HA	NNP
cord-005081-kxrzv16n	303	10	and	and	CC
cord-005081-kxrzv16n	303	11	NA	NA	NNP
cord-005081-kxrzv16n	303	12	proteolysis	proteolysis	NN
cord-005081-kxrzv16n	303	13	and	and	CC
cord-005081-kxrzv16n	303	14	their	-PRON-	PRP$
cord-005081-kxrzv16n	303	15	dependence	dependence	NN
cord-005081-kxrzv16n	303	16	on	on	IN
cord-005081-kxrzv16n	303	17	membrane	membrane	NN
cord-005081-kxrzv16n	303	18	bound	bind	VBN
cord-005081-kxrzv16n	303	19	cellular	cellular	JJ
cord-005081-kxrzv16n	303	20	proteases	protease	NNS
cord-005081-kxrzv16n	303	21	[	[	-LRB-
cord-005081-kxrzv16n	303	22	12	12	CD
cord-005081-kxrzv16n	303	23	]	]	-RRB-
cord-005081-kxrzv16n	303	24	,	,	,
cord-005081-kxrzv16n	303	25	a	a	DT
cord-005081-kxrzv16n	303	26	systemic	systemic	JJ
cord-005081-kxrzv16n	303	27	induction	induction	NN
cord-005081-kxrzv16n	303	28	of	of	IN
cord-005081-kxrzv16n	303	29	a	a	DT
cord-005081-kxrzv16n	303	30	"	"	``
cord-005081-kxrzv16n	303	31	cytokine	cytokine	NN
cord-005081-kxrzv16n	303	32	storm	storm	NN
cord-005081-kxrzv16n	303	33	"	"	''
cord-005081-kxrzv16n	303	34	.	.	.
cord-005081-kxrzv16n	304	1	(	(	-LRB-
cord-005081-kxrzv16n	304	2	3	3	LS
cord-005081-kxrzv16n	304	3	)	)	-RRB-
cord-005081-kxrzv16n	304	4	NS1	NS1	NNS
cord-005081-kxrzv16n	304	5	and	and	CC
cord-005081-kxrzv16n	304	6	NS2	NS2	NNP
cord-005081-kxrzv16n	304	7	conditioned	condition	VBD
cord-005081-kxrzv16n	304	8	opposition	opposition	NN
cord-005081-kxrzv16n	304	9	of	of	IN
cord-005081-kxrzv16n	304	10	the	the	DT
cord-005081-kxrzv16n	304	11	interferon	interferon	NN
cord-005081-kxrzv16n	304	12	system	system	NN
cord-005081-kxrzv16n	304	13	and	and	CC
cord-005081-kxrzv16n	304	14	immunosuppression	immunosuppression	NN
cord-005081-kxrzv16n	304	15	.	.	.
cord-005081-kxrzv16n	305	1	(	(	-LRB-
cord-005081-kxrzv16n	305	2	4	4	LS
cord-005081-kxrzv16n	305	3	)	)	-RRB-
cord-005081-kxrzv16n	305	4	Presence	presence	NN
cord-005081-kxrzv16n	305	5	of	of	IN
cord-005081-kxrzv16n	305	6	the	the	DT
cord-005081-kxrzv16n	305	7	"	"	``
cord-005081-kxrzv16n	305	8	weakened	weakened	JJ
cord-005081-kxrzv16n	305	9	"	"	''
cord-005081-kxrzv16n	305	10	consensus	consensus	NN
cord-005081-kxrzv16n	305	11	sequence	sequence	NN
cord-005081-kxrzv16n	305	12	of	of	IN
cord-005081-kxrzv16n	305	13	the	the	DT
cord-005081-kxrzv16n	305	14	Ebola	Ebola	NNP
cord-005081-kxrzv16n	305	15	like	like	IN
cord-005081-kxrzv16n	305	16	suppressive	suppressive	JJ
cord-005081-kxrzv16n	305	17	domain	domain	NN
cord-005081-kxrzv16n	305	18	[	[	-LRB-
cord-005081-kxrzv16n	305	19	12	12	CD
cord-005081-kxrzv16n	305	20	]	]	-RRB-
cord-005081-kxrzv16n	305	21	.	.	.
cord-005081-kxrzv16n	306	1	However	however	RB
cord-005081-kxrzv16n	306	2	,	,	,
cord-005081-kxrzv16n	306	3	it	-PRON-	PRP
cord-005081-kxrzv16n	306	4	should	should	MD
cord-005081-kxrzv16n	306	5	be	be	VB
cord-005081-kxrzv16n	306	6	underlined	underline	VBN
cord-005081-kxrzv16n	306	7	that	that	IN
cord-005081-kxrzv16n	306	8	the	the	DT
cord-005081-kxrzv16n	306	9	above	above	JJ
cord-005081-kxrzv16n	306	10	defects	defect	NNS
cord-005081-kxrzv16n	306	11	may	may	MD
cord-005081-kxrzv16n	306	12	in	in	IN
cord-005081-kxrzv16n	306	13	part	part	NN
cord-005081-kxrzv16n	306	14	or	or	CC
cord-005081-kxrzv16n	306	15	fully	fully	RB
cord-005081-kxrzv16n	306	16	be	be	VB
cord-005081-kxrzv16n	306	17	repaired	repair	VBN
cord-005081-kxrzv16n	306	18	in	in	IN
cord-005081-kxrzv16n	306	19	the	the	DT
cord-005081-kxrzv16n	306	20	process	process	NN
cord-005081-kxrzv16n	306	21	of	of	IN
cord-005081-kxrzv16n	306	22	active	active	JJ
cord-005081-kxrzv16n	306	23	circulation	circulation	NN
cord-005081-kxrzv16n	306	24	of	of	IN
cord-005081-kxrzv16n	306	25	the	the	DT
cord-005081-kxrzv16n	306	26	H1N1sw	H1N1sw	NNP
cord-005081-kxrzv16n	306	27	viruses	virus	NNS
cord-005081-kxrzv16n	306	28	,	,	,
cord-005081-kxrzv16n	306	29	carrying	carry	VBG
cord-005081-kxrzv16n	306	30	a	a	DT
cord-005081-kxrzv16n	306	31	risk	risk	NN
cord-005081-kxrzv16n	306	32	of	of	IN
cord-005081-kxrzv16n	306	33	enhanced	enhance	VBN
cord-005081-kxrzv16n	306	34	pathogenicity	pathogenicity	NN
cord-005081-kxrzv16n	306	35	.	.	.
cord-005081-kxrzv16n	307	1	Therefore	therefore	RB
cord-005081-kxrzv16n	307	2	,	,	,
cord-005081-kxrzv16n	307	3	in	in	IN
cord-005081-kxrzv16n	307	4	con	con	FW
cord-005081-kxrzv16n	307	5	structing	structe	VBG
cord-005081-kxrzv16n	307	6	vaccines	vaccine	NNS
cord-005081-kxrzv16n	307	7	for	for	IN
cord-005081-kxrzv16n	307	8	the	the	DT
cord-005081-kxrzv16n	307	9	forthcoming	forthcoming	JJ
cord-005081-kxrzv16n	307	10	pandemic	pandemic	NN
cord-005081-kxrzv16n	307	11	sea	sea	NN
cord-005081-kxrzv16n	307	12	sons	son	NNS
cord-005081-kxrzv16n	307	13	we	-PRON-	PRP
cord-005081-kxrzv16n	307	14	shall	shall	MD
cord-005081-kxrzv16n	307	15	have	have	VB
cord-005081-kxrzv16n	307	16	to	to	TO
cord-005081-kxrzv16n	307	17	foresee	foresee	VB
cord-005081-kxrzv16n	307	18	the	the	DT
cord-005081-kxrzv16n	307	19	constructive	constructive	JJ
cord-005081-kxrzv16n	307	20	specific	specific	JJ
cord-005081-kxrzv16n	307	21	features	feature	NNS
cord-005081-kxrzv16n	307	22	associated	associate	VBN
cord-005081-kxrzv16n	307	23	with	with	IN
cord-005081-kxrzv16n	307	24	a	a	DT
cord-005081-kxrzv16n	307	25	probable	probable	JJ
cord-005081-kxrzv16n	307	26	emergence	emergence	NN
cord-005081-kxrzv16n	307	27	of	of	IN
cord-005081-kxrzv16n	307	28	viruses	virus	NNS
cord-005081-kxrzv16n	307	29	with	with	IN
cord-005081-kxrzv16n	307	30	modified	modify	VBN
cord-005081-kxrzv16n	307	31	properties	property	NNS
cord-005081-kxrzv16n	307	32	.	.	.
cord-005081-kxrzv16n	308	1	As	as	IN
cord-005081-kxrzv16n	308	2	the	the	DT
cord-005081-kxrzv16n	308	3	most	most	RBS
cord-005081-kxrzv16n	308	4	marked	marked	JJ
cord-005081-kxrzv16n	308	5	achievements	achievement	NNS
cord-005081-kxrzv16n	308	6	in	in	IN
cord-005081-kxrzv16n	308	7	domestic	domestic	JJ
cord-005081-kxrzv16n	308	8	sci	sci	NNP
cord-005081-kxrzv16n	308	9	ence	ence	NNP
cord-005081-kxrzv16n	308	10	,	,	,
cord-005081-kxrzv16n	308	11	we	-PRON-	PRP
cord-005081-kxrzv16n	308	12	should	should	MD
cord-005081-kxrzv16n	308	13	note	note	VB
cord-005081-kxrzv16n	308	14	the	the	DT
cord-005081-kxrzv16n	308	15	obtaining	obtaining	NN
cord-005081-kxrzv16n	308	16	of	of	IN
cord-005081-kxrzv16n	308	17	a	a	DT
cord-005081-kxrzv16n	308	18	full	full	JJ
cord-005081-kxrzv16n	308	19	functional	functional	JJ
cord-005081-kxrzv16n	308	20	copy	copy	NN
cord-005081-kxrzv16n	308	21	of	of	IN
cord-005081-kxrzv16n	308	22	the	the	DT
cord-005081-kxrzv16n	308	23	Kurgan	Kurgan	NNP
cord-005081-kxrzv16n	308	24	isolates	isolate	VBZ
cord-005081-kxrzv16n	308	25	for	for	IN
cord-005081-kxrzv16n	308	26	the	the	DT
cord-005081-kxrzv16n	308	27	avian	avian	JJ
cord-005081-kxrzv16n	308	28	influenza	influenza	NN
cord-005081-kxrzv16n	308	29	H5N1	H5N1	NNP
cord-005081-kxrzv16n	308	30	virus	virus	NN
cord-005081-kxrzv16n	308	31	using	use	VBG
cord-005081-kxrzv16n	308	32	the	the	DT
cord-005081-kxrzv16n	308	33	recursive	recursive	JJ
cord-005081-kxrzv16n	308	34	PCR	pcr	NN
cord-005081-kxrzv16n	308	35	and	and	CC
cord-005081-kxrzv16n	308	36	reverse	reverse	VB
cord-005081-kxrzv16n	308	37	genetics	genetics	NN
cord-005081-kxrzv16n	308	38	techniques	technique	NNS
cord-005081-kxrzv16n	308	39	(	(	-LRB-
cord-005081-kxrzv16n	308	40	8	8	CD
cord-005081-kxrzv16n	308	41	plasmid	plasmid	NN
cord-005081-kxrzv16n	308	42	system	system	NN
cord-005081-kxrzv16n	308	43	variation	variation	NN
cord-005081-kxrzv16n	308	44	[	[	-LRB-
cord-005081-kxrzv16n	308	45	12	12	CD
cord-005081-kxrzv16n	308	46	]	]	-RRB-
cord-005081-kxrzv16n	308	47	)	)	-RRB-
cord-005081-kxrzv16n	308	48	and	and	CC
cord-005081-kxrzv16n	308	49	the	the	DT
cord-005081-kxrzv16n	308	50	technology	technology	NN
cord-005081-kxrzv16n	308	51	created	create	VBN
cord-005081-kxrzv16n	308	52	for	for	IN
cord-005081-kxrzv16n	308	53	producing	produce	VBG
cord-005081-kxrzv16n	308	54	a	a	DT
cord-005081-kxrzv16n	308	55	universal	universal	JJ
cord-005081-kxrzv16n	308	56	vaccine	vaccine	NN
cord-005081-kxrzv16n	308	57	based	base	VBN
cord-005081-kxrzv16n	308	58	on	on	IN
cord-005081-kxrzv16n	308	59	the	the	DT
cord-005081-kxrzv16n	308	60	M2	M2	NNP
cord-005081-kxrzv16n	308	61	protein	protein	NN
cord-005081-kxrzv16n	308	62	[	[	-LRB-
cord-005081-kxrzv16n	308	63	14	14	CD
cord-005081-kxrzv16n	308	64	]	]	-RRB-
cord-005081-kxrzv16n	308	65	.	.	.
cord-005081-kxrzv16n	309	1	Gripp	Gripp	NNP
cord-005081-kxrzv16n	309	2	ptits	ptit	NNS
cord-005081-kxrzv16n	309	3	:	:	:
cord-005081-kxrzv16n	309	4	proiskhozhdenie	proiskhozhdenie	NNP
cord-005081-kxrzv16n	309	5	infektsionnykh	infektsionnykh	NNP
cord-005081-kxrzv16n	309	6	biokatastrof	biokatastrof	NNP
cord-005081-kxrzv16n	310	1	(	(	-LRB-
cord-005081-kxrzv16n	310	2	Avian	Avian	NNP
cord-005081-kxrzv16n	310	3	Influenza	Influenza	NNP
cord-005081-kxrzv16n	310	4	:	:	:
cord-005081-kxrzv16n	311	1	The	the	DT
cord-005081-kxrzv16n	311	2	Origin	Origin	NNP
cord-005081-kxrzv16n	311	3	of	of	IN
cord-005081-kxrzv16n	311	4	Infectious	Infectious	NNP
cord-005081-kxrzv16n	311	5	Biocatastrophes	Biocatastrophes	NNPS
cord-005081-kxrzv16n	311	6	)	)	-RRB-
cord-005081-kxrzv16n	311	7	Gripp	Gripp	NNP
cord-005081-kxrzv16n	311	8	.	.	.
cord-005081-kxrzv16n	312	1	Na	Na	NNP
cord-005081-kxrzv16n	312	2	poroge	poroge	NNP
cord-005081-kxrzv16n	312	3	pandemii	pandemii	NNP
cord-005081-kxrzv16n	313	1	(	(	-LRB-
cord-005081-kxrzv16n	313	2	Influenza	influenza	NN
cord-005081-kxrzv16n	313	3	:	:	:
cord-005081-kxrzv16n	313	4	On	on	IN
cord-005081-kxrzv16n	313	5	the	the	DT
cord-005081-kxrzv16n	313	6	Brink	Brink	NNP
cord-005081-kxrzv16n	313	7	of	of	IN
cord-005081-kxrzv16n	313	8	Pandemia	Pandemia	NNP
cord-005081-kxrzv16n	313	9	)	)	-RRB-
cord-005081-kxrzv16n	314	1	Etiologiya	Etiologiya	NNP
cord-005081-kxrzv16n	314	2	,	,	,
cord-005081-kxrzv16n	314	3	immunologiya	immunologiya	NNP
cord-005081-kxrzv16n	314	4	i	i	NNP
cord-005081-kxrzv16n	314	5	klin	klin	NNP
cord-005081-kxrzv16n	314	6	ika	ika	NNP
cord-005081-kxrzv16n	314	7	aziatskogo	aziatskogo	NNP
cord-005081-kxrzv16n	315	1	grippa	grippa	NNP
cord-005081-kxrzv16n	315	2	Mezhdunarod	Mezhdunarod	NNP
cord-005081-kxrzv16n	315	3	naya	naya	NNP
cord-005081-kxrzv16n	315	4	Konferentsiya	Konferentsiya	NNP
cord-005081-kxrzv16n	315	5	(	(	-LRB-
cord-005081-kxrzv16n	315	6	Bull	Bull	NNP
cord-005081-kxrzv16n	315	7	.	.	.
cord-005081-kxrzv16n	315	8	WHO	who	WP
cord-005081-kxrzv16n	315	9	.	.	.
cord-005081-kxrzv16n	316	1	Hong	Hong	NNP
cord-005081-kxrzv16n	316	2	Kong	Kong	NNP
cord-005081-kxrzv16n	316	3	Flu	Flu	NNP
cord-005081-kxrzv16n	316	4	.	.	.
cord-005081-kxrzv16n	317	1	Int	Int	NNP
cord-005081-kxrzv16n	317	2	.	.	NNP
cord-005081-kxrzv16n	317	3	Conf	Conf	NNP
cord-005081-kxrzv16n	317	4	.	.	NNP
cord-005081-kxrzv16n	317	5	)	)	-RRB-
cord-005081-kxrzv16n	317	6	,	,	,
cord-005081-kxrzv16n	317	7	1969	1969	CD
cord-005081-kxrzv16n	317	8	Pandemiya-2009	Pandemiya-2009	NNP
cord-005081-kxrzv16n	317	9	.	.	.
cord-005081-kxrzv16n	318	1	Novyi	Novyi	NNP
cord-005081-kxrzv16n	318	2	virus	virus	NN
cord-005081-kxrzv16n	318	3	H1N1	H1N1	NNP
cord-005081-kxrzv16n	318	4	(	(	-LRB-
cord-005081-kxrzv16n	318	5	Pandemia-2009	Pandemia-2009	NNP
cord-005081-kxrzv16n	318	6	.	.	.
cord-005081-kxrzv16n	319	1	New	New	NNP
cord-005081-kxrzv16n	319	2	Virus	Virus	NNP
cord-005081-kxrzv16n	319	3	H1N1	H1N1	NNP
cord-005081-kxrzv16n	319	4	)	)	-RRB-
cord-005081-kxrzv16n	320	1	Note	note	VB
cord-005081-kxrzv16n	320	2	for	for	IN
cord-005081-kxrzv16n	320	3	Guidance	guidance	NN
cord-005081-kxrzv16n	320	4	on	on	IN
cord-005081-kxrzv16n	320	5	Harmonization	Harmonization	NNP
cord-005081-kxrzv16n	320	6	of	of	IN
cord-005081-kxrzv16n	320	7	Requirements	Requirements	NNPS
cord-005081-kxrzv16n	320	8	for	for	IN
cord-005081-kxrzv16n	320	9	Influenza	Influenza	NNP
cord-005081-kxrzv16n	320	10	Vaccines	Vaccines	NNPS
cord-005081-kxrzv16n	320	11	.	.	.
cord-005081-kxrzv16n	321	1	1997	1997	CD
cord-005081-kxrzv16n	321	2	(	(	-LRB-
cord-005081-kxrzv16n	321	3	COMP	COMP	NNP
cord-005081-kxrzv16n	321	4	/	/	SYM
cord-005081-kxrzv16n	321	5	BWP/214/96	BWP/214/96	NNP
cord-005081-kxrzv16n	321	6	)	)	-RRB-
cord-005081-kxrzv16n	321	7	.	.	.
cord-005081-kxrzv16n	322	1	Euro	Euro	NNP
cord-005081-kxrzv16n	322	2	pean	pean	NNP
cord-005081-kxrzv16n	322	3	Agency	Agency	NNP
cord-005081-kxrzv16n	322	4	for	for	IN
cord-005081-kxrzv16n	322	5	the	the	DT
cord-005081-kxrzv16n	322	6	Evaluation	Evaluation	NNP
cord-005081-kxrzv16n	322	7	of	of	IN
cord-005081-kxrzv16n	322	8	Medicinal	Medicinal	NNP
cord-005081-kxrzv16n	322	9	Products	Products	NNPS
cord-005081-kxrzv16n	323	1	The	the	DT
cord-005081-kxrzv16n	323	2	Lan	Lan	NNP
cord-005081-kxrzv16n	323	3	cet	cet	NN
cord-005081-kxrzv16n	323	4	WHO	who	WP
cord-005081-kxrzv16n	323	5	Guid	Guid	NNP
cord-005081-kxrzv16n	323	6	ance	ance	NN
cord-005081-kxrzv16n	323	7	on	on	IN
cord-005081-kxrzv16n	323	8	Development	Development	NNP
cord-005081-kxrzv16n	323	9	of	of	IN
cord-005081-kxrzv16n	323	10	Influenza	Influenza	NNP
cord-005081-kxrzv16n	323	11	Vaccine	Vaccine	NNP
cord-005081-kxrzv16n	323	12	Reference	Reference	NNP
cord-005081-kxrzv16n	323	13	Viruses	virus	NNS
cord-005081-kxrzv16n	323	14	by	by	IN
cord-005081-kxrzv16n	323	15	Reverse	Reverse	NNP
cord-005081-kxrzv16n	323	16	Genetics	Genetics	NNP
cord-005081-kxrzv16n	324	1	A	a	DT
cord-005081-kxrzv16n	324	2	Review	Review	NNP
cord-005081-kxrzv16n	324	3	of	of	IN
cord-005081-kxrzv16n	324	4	Production	Production	NNP
cord-005081-kxrzv16n	324	5	Technologies	Technologies	NNPS
cord-005081-kxrzv16n	324	6	for	for	IN
cord-005081-kxrzv16n	324	7	Influenza	Influenza	NNP
cord-005081-kxrzv16n	324	8	Virus	Virus	NNP
cord-005081-kxrzv16n	324	9	Vaccines	Vaccines	NNPS
cord-005081-kxrzv16n	324	10	and	and	CC
cord-005081-kxrzv16n	324	11	Their	-PRON-	PRP$
cord-005081-kxrzv16n	324	12	Suit	Suit	NNP
cord-005081-kxrzv16n	324	13	ability	ability	NN
cord-005081-kxrzv16n	324	14	for	for	IN
cord-005081-kxrzv16n	324	15	Deployment	deployment	NN
cord-005081-kxrzv16n	324	16	in	in	IN
cord-005081-kxrzv16n	324	17	Developing	develop	VBG
cord-005081-kxrzv16n	324	18	Countries	Countries	NNPS
cord-005081-kxrzv16n	324	19	for	for	IN
cord-005081-kxrzv16n	324	20	Influ	Influ	NNP
cord-005081-kxrzv16n	324	21	enza	enza	NNP
cord-005081-kxrzv16n	324	22	Pandemic	Pandemic	NNP
cord-005081-kxrzv16n	324	23	Preparedness	Preparedness	NNP
cord-005081-kxrzv16n	324	24	.	.	.
cord-005081-kxrzv16n	325	1	World	World	NNP
cord-005081-kxrzv16n	325	2	Health	Health	NNP
cord-005081-kxrzv16n	325	3	Organiza	Organiza	NNP
cord-005081-kxrzv16n	325	4	tion	tion	NNP
cord-005081-kxrzv16n	325	5	Initiative	Initiative	NNP
cord-005081-kxrzv16n	325	6	for	for	IN
cord-005081-kxrzv16n	325	7	Vaccine	Vaccine	NNP
cord-005081-kxrzv16n	325	8	Research	Research	NNP
cord-005081-kxrzv16n	325	9	Proc	Proc	NNP
cord-005081-kxrzv16n	325	10	.	.	.
cord-005081-kxrzv16n	326	1	Natl	Natl	NNP
cord-005081-kxrzv16n	326	2	.	.	.
cord-005081-kxrzv16n	327	1	Acad	Acad	NNP
cord-005081-kxrzv16n	327	2	.	.	.
cord-005081-kxrzv16n	328	1	Sci	Sci	NNP
cord-005081-kxrzv16n	328	2	.	.	NNP
cord-005081-kxrzv16n	328	3	USA	USA	NNP