id sid tid token lemma pos cord-006252-cbelsymu 1 1 key key JJ cord-006252-cbelsymu 1 2 : : : cord-006252-cbelsymu 1 3 cord-006252-cbelsymu cord-006252-cbelsymu . cord-006252-cbelsymu 2 1 authors author NNS cord-006252-cbelsymu 2 2 : : : cord-006252-cbelsymu 2 3 Gross gross JJ cord-006252-cbelsymu 2 4 , , , cord-006252-cbelsymu 3 1 Peter Peter NNP cord-006252-cbelsymu 3 2 A. a. NN cord-006252-cbelsymu 3 3 title title NN cord-006252-cbelsymu 3 4 : : : cord-006252-cbelsymu 4 1 Current current JJ cord-006252-cbelsymu 4 2 Recommendations Recommendations NNPS cord-006252-cbelsymu 4 3 for for IN cord-006252-cbelsymu 4 4 the the DT cord-006252-cbelsymu 4 5 Prevention Prevention NNP cord-006252-cbelsymu 4 6 and and CC cord-006252-cbelsymu 4 7 Treatment Treatment NNP cord-006252-cbelsymu 4 8 of of IN cord-006252-cbelsymu 4 9 Influenza Influenza NNP cord-006252-cbelsymu 4 10 in in IN cord-006252-cbelsymu 4 11 the the DT cord-006252-cbelsymu 4 12 Older Older NNP cord-006252-cbelsymu 4 13 Population Population NNP cord-006252-cbelsymu 4 14 date date NN cord-006252-cbelsymu 4 15 : : : cord-006252-cbelsymu 4 16 2012 2012 CD cord-006252-cbelsymu 4 17 - - SYM cord-006252-cbelsymu 4 18 11 11 CD cord-006252-cbelsymu 4 19 - - SYM cord-006252-cbelsymu 4 20 18 18 CD cord-006252-cbelsymu 4 21 journal journal NN cord-006252-cbelsymu 4 22 : : : cord-006252-cbelsymu 5 1 Drugs drug NNS cord-006252-cbelsymu 5 2 Aging age VBG cord-006252-cbelsymu 5 3 DOI doi NN cord-006252-cbelsymu 5 4 : : : cord-006252-cbelsymu 5 5 10.2165/00002512 10.2165/00002512 CD cord-006252-cbelsymu 5 6 - - HYPH cord-006252-cbelsymu 5 7 199101060 199101060 CD cord-006252-cbelsymu 5 8 - - HYPH cord-006252-cbelsymu 5 9 00003 00003 CD cord-006252-cbelsymu 6 1 sha sha NNP cord-006252-cbelsymu 6 2 : : : cord-006252-cbelsymu 6 3 31f4b44422268b514ecada6a2ad1c4ef16abc98f 31f4b44422268b514ecada6a2ad1c4ef16abc98f CD cord-006252-cbelsymu 6 4 doc_id doc_id CD cord-006252-cbelsymu 6 5 : : : cord-006252-cbelsymu 7 1 6252 6252 CD cord-006252-cbelsymu 7 2 cord_uid cord_uid FW cord-006252-cbelsymu 7 3 : : : cord-006252-cbelsymu 8 1 cbelsymu cbelsymu NNP cord-006252-cbelsymu 8 2 Influenza Influenza NNP cord-006252-cbelsymu 8 3 is be VBZ cord-006252-cbelsymu 8 4 a a DT cord-006252-cbelsymu 8 5 major major JJ cord-006252-cbelsymu 8 6 cause cause NN cord-006252-cbelsymu 8 7 of of IN cord-006252-cbelsymu 8 8 morbidity morbidity NN cord-006252-cbelsymu 8 9 and and CC cord-006252-cbelsymu 8 10 mortality mortality NN cord-006252-cbelsymu 8 11 in in IN cord-006252-cbelsymu 8 12 the the DT cord-006252-cbelsymu 8 13 elderly elderly JJ cord-006252-cbelsymu 8 14 . . . cord-006252-cbelsymu 9 1 Influenza influenza NN cord-006252-cbelsymu 9 2 vaccine vaccine NN cord-006252-cbelsymu 9 3 is be VBZ cord-006252-cbelsymu 9 4 recommended recommend VBN cord-006252-cbelsymu 9 5 for for IN cord-006252-cbelsymu 9 6 people people NNS cord-006252-cbelsymu 9 7 aged age VBN cord-006252-cbelsymu 9 8 65 65 CD cord-006252-cbelsymu 9 9 years year NNS cord-006252-cbelsymu 9 10 and and CC cord-006252-cbelsymu 9 11 older old JJR cord-006252-cbelsymu 9 12 and and CC cord-006252-cbelsymu 9 13 those those DT cord-006252-cbelsymu 9 14 in in IN cord-006252-cbelsymu 9 15 long long JJ cord-006252-cbelsymu 9 16 term term NN cord-006252-cbelsymu 9 17 care care NN cord-006252-cbelsymu 9 18 . . . cord-006252-cbelsymu 10 1 Currently currently RB cord-006252-cbelsymu 10 2 only only RB cord-006252-cbelsymu 10 3 30 30 CD cord-006252-cbelsymu 10 4 % % NN cord-006252-cbelsymu 10 5 of of IN cord-006252-cbelsymu 10 6 high high JJ cord-006252-cbelsymu 10 7 risk risk NN cord-006252-cbelsymu 10 8 persons person NNS cord-006252-cbelsymu 10 9 are be VBP cord-006252-cbelsymu 10 10 vaccinated vaccinate VBN cord-006252-cbelsymu 10 11 . . . cord-006252-cbelsymu 11 1 Vaccination vaccination NN cord-006252-cbelsymu 11 2 generally generally RB cord-006252-cbelsymu 11 3 stimulates stimulate VBZ cord-006252-cbelsymu 11 4 an an DT cord-006252-cbelsymu 11 5 adequate adequate JJ cord-006252-cbelsymu 11 6 immune immune JJ cord-006252-cbelsymu 11 7 response response NN cord-006252-cbelsymu 11 8 , , , cord-006252-cbelsymu 11 9 is be VBZ cord-006252-cbelsymu 11 10 well well RB cord-006252-cbelsymu 11 11 tolerated tolerate VBN cord-006252-cbelsymu 11 12 and and CC cord-006252-cbelsymu 11 13 is be VBZ cord-006252-cbelsymu 11 14 to to TO cord-006252-cbelsymu 11 15 be be VB cord-006252-cbelsymu 11 16 encouraged encourage VBN cord-006252-cbelsymu 11 17 . . . cord-006252-cbelsymu 12 1 Prophylactic prophylactic JJ cord-006252-cbelsymu 12 2 amantadine amantadine NNP cord-006252-cbelsymu 12 3 100 100 CD cord-006252-cbelsymu 12 4 mg mg NNP cord-006252-cbelsymu 12 5 / / SYM cord-006252-cbelsymu 12 6 day day NN cord-006252-cbelsymu 12 7 should should MD cord-006252-cbelsymu 12 8 be be VB cord-006252-cbelsymu 12 9 given give VBN cord-006252-cbelsymu 12 10 for for IN cord-006252-cbelsymu 12 11 2 2 CD cord-006252-cbelsymu 12 12 weeks week NNS cord-006252-cbelsymu 12 13 with with IN cord-006252-cbelsymu 12 14 influenza influenza NN cord-006252-cbelsymu 12 15 vaccine vaccine NN cord-006252-cbelsymu 12 16 in in IN cord-006252-cbelsymu 12 17 the the DT cord-006252-cbelsymu 12 18 aged aged JJ cord-006252-cbelsymu 12 19 population population NN cord-006252-cbelsymu 12 20 when when WRB cord-006252-cbelsymu 12 21 they -PRON- PRP cord-006252-cbelsymu 12 22 have have VBP cord-006252-cbelsymu 12 23 not not RB cord-006252-cbelsymu 12 24 been be VBN cord-006252-cbelsymu 12 25 previously previously RB cord-006252-cbelsymu 12 26 immunised immunise VBN cord-006252-cbelsymu 12 27 . . . cord-006252-cbelsymu 13 1 Broad broad JJ cord-006252-cbelsymu 13 2 application application NN cord-006252-cbelsymu 13 3 of of IN cord-006252-cbelsymu 13 4 these these DT cord-006252-cbelsymu 13 5 preventive preventive JJ cord-006252-cbelsymu 13 6 measures measure NNS cord-006252-cbelsymu 13 7 would would MD cord-006252-cbelsymu 13 8 have have VB cord-006252-cbelsymu 13 9 a a DT cord-006252-cbelsymu 13 10 significant significant JJ cord-006252-cbelsymu 13 11 impact impact NN cord-006252-cbelsymu 13 12 on on IN cord-006252-cbelsymu 13 13 reducing reduce VBG cord-006252-cbelsymu 13 14 influenza influenza NN cord-006252-cbelsymu 13 15 prevalence prevalence NN cord-006252-cbelsymu 13 16 in in IN cord-006252-cbelsymu 13 17 the the DT cord-006252-cbelsymu 13 18 elderly elderly JJ cord-006252-cbelsymu 13 19 and and CC cord-006252-cbelsymu 13 20 other other JJ cord-006252-cbelsymu 13 21 high high JJ cord-006252-cbelsymu 13 22 risk risk NN cord-006252-cbelsymu 13 23 groups group NNS cord-006252-cbelsymu 13 24 . . . cord-006252-cbelsymu 14 1 Influenza influenza NN cord-006252-cbelsymu 14 2 is be VBZ cord-006252-cbelsymu 14 3 a a DT cord-006252-cbelsymu 14 4 major major JJ cord-006252-cbelsymu 14 5 cause cause NN cord-006252-cbelsymu 14 6 of of IN cord-006252-cbelsymu 14 7 morbidity morbidity NN cord-006252-cbelsymu 14 8 and and CC cord-006252-cbelsymu 14 9 mortality mortality NN cord-006252-cbelsymu 14 10 in in IN cord-006252-cbelsymu 14 11 the the DT cord-006252-cbelsymu 14 12 elderly elderly JJ cord-006252-cbelsymu 14 13 . . . cord-006252-cbelsymu 15 1 Influenza influenza NN cord-006252-cbelsymu 15 2 vaccine vaccine NN cord-006252-cbelsymu 15 3 is be VBZ cord-006252-cbelsymu 15 4 recommended recommend VBN cord-006252-cbelsymu 15 5 for for IN cord-006252-cbelsymu 15 6 people people NNS cord-006252-cbelsymu 15 7 aged age VBN cord-006252-cbelsymu 15 8 65 65 CD cord-006252-cbelsymu 15 9 years year NNS cord-006252-cbelsymu 15 10 and and CC cord-006252-cbelsymu 15 11 older old JJR cord-006252-cbelsymu 15 12 and and CC cord-006252-cbelsymu 15 13 those those DT cord-006252-cbelsymu 15 14 in in IN cord-006252-cbelsymu 15 15 long long JJ cord-006252-cbelsymu 15 16 term term NN cord-006252-cbelsymu 15 17 care care NN cord-006252-cbelsymu 15 18 . . . cord-006252-cbelsymu 16 1 Currently currently RB cord-006252-cbelsymu 16 2 only only RB cord-006252-cbelsymu 16 3 30 30 CD cord-006252-cbelsymu 16 4 % % NN cord-006252-cbelsymu 16 5 of of IN cord-006252-cbelsymu 16 6 high high JJ cord-006252-cbelsymu 16 7 risk risk NN cord-006252-cbelsymu 16 8 persons person NNS cord-006252-cbelsymu 16 9 are be VBP cord-006252-cbelsymu 16 10 vaccinated vaccinate VBN cord-006252-cbelsymu 16 11 . . . cord-006252-cbelsymu 17 1 Vaccination vaccination NN cord-006252-cbelsymu 17 2 generally generally RB cord-006252-cbelsymu 17 3 stimulates stimulate VBZ cord-006252-cbelsymu 17 4 an an DT cord-006252-cbelsymu 17 5 adequate adequate JJ cord-006252-cbelsymu 17 6 immune immune JJ cord-006252-cbelsymu 17 7 response response NN cord-006252-cbelsymu 17 8 , , , cord-006252-cbelsymu 17 9 is be VBZ cord-006252-cbelsymu 17 10 well well RB cord-006252-cbelsymu 17 11 tolerated tolerate VBN cord-006252-cbelsymu 17 12 and and CC cord-006252-cbelsymu 17 13 is be VBZ cord-006252-cbelsymu 17 14 to to TO cord-006252-cbelsymu 17 15 be be VB cord-006252-cbelsymu 17 16 encouraged encourage VBN cord-006252-cbelsymu 17 17 . . . cord-006252-cbelsymu 18 1 Prophylactic prophylactic JJ cord-006252-cbelsymu 18 2 amantadine amantadine NNP cord-006252-cbelsymu 18 3 100 100 CD cord-006252-cbelsymu 18 4 mgjday mgjday NN cord-006252-cbelsymu 18 5 should should MD cord-006252-cbelsymu 18 6 be be VB cord-006252-cbelsymu 18 7 given give VBN cord-006252-cbelsymu 18 8 for for IN cord-006252-cbelsymu 18 9 2 2 CD cord-006252-cbelsymu 18 10 weeks week NNS cord-006252-cbelsymu 18 11 with with IN cord-006252-cbelsymu 18 12 influenza influenza NN cord-006252-cbelsymu 18 13 vaccine vaccine NN cord-006252-cbelsymu 18 14 in in IN cord-006252-cbelsymu 18 15 the the DT cord-006252-cbelsymu 18 16 aged aged JJ cord-006252-cbelsymu 18 17 population population NN cord-006252-cbelsymu 18 18 when when WRB cord-006252-cbelsymu 18 19 they -PRON- PRP cord-006252-cbelsymu 18 20 have have VBP cord-006252-cbelsymu 18 21 not not RB cord-006252-cbelsymu 18 22 been be VBN cord-006252-cbelsymu 18 23 previously previously RB cord-006252-cbelsymu 18 24 immunised immunise VBN cord-006252-cbelsymu 18 25 . . . cord-006252-cbelsymu 19 1 Broad broad JJ cord-006252-cbelsymu 19 2 application application NN cord-006252-cbelsymu 19 3 of of IN cord-006252-cbelsymu 19 4 these these DT cord-006252-cbelsymu 19 5 preventive preventive JJ cord-006252-cbelsymu 19 6 measures measure NNS cord-006252-cbelsymu 19 7 would would MD cord-006252-cbelsymu 19 8 have have VB cord-006252-cbelsymu 19 9 a a DT cord-006252-cbelsymu 19 10 significant significant JJ cord-006252-cbelsymu 19 11 impact impact NN cord-006252-cbelsymu 19 12 on on IN cord-006252-cbelsymu 19 13 reducing reduce VBG cord-006252-cbelsymu 19 14 influenza influenza NN cord-006252-cbelsymu 19 15 prevalence prevalence NN cord-006252-cbelsymu 19 16 in in IN cord-006252-cbelsymu 19 17 the the DT cord-006252-cbelsymu 19 18 elderly elderly JJ cord-006252-cbelsymu 19 19 and and CC cord-006252-cbelsymu 19 20 other other JJ cord-006252-cbelsymu 19 21 high high JJ cord-006252-cbelsymu 19 22 risk risk NN cord-006252-cbelsymu 19 23 groups group NNS cord-006252-cbelsymu 19 24 . . . cord-006252-cbelsymu 20 1 If if IN cord-006252-cbelsymu 20 2 we -PRON- PRP cord-006252-cbelsymu 20 3 were be VBD cord-006252-cbelsymu 20 4 more more RBR cord-006252-cbelsymu 20 5 aware aware JJ cord-006252-cbelsymu 20 6 of of IN cord-006252-cbelsymu 20 7 the the DT cord-006252-cbelsymu 20 8 full full JJ cord-006252-cbelsymu 20 9 impact impact NN cord-006252-cbelsymu 20 10 of of IN cord-006252-cbelsymu 20 11 influenza influenza NN cord-006252-cbelsymu 20 12 on on IN cord-006252-cbelsymu 20 13 our -PRON- PRP$ cord-006252-cbelsymu 20 14 lives life NNS cord-006252-cbelsymu 20 15 , , , cord-006252-cbelsymu 20 16 we -PRON- PRP cord-006252-cbelsymu 20 17 would would MD cord-006252-cbelsymu 20 18 be be VB cord-006252-cbelsymu 20 19 more more RBR cord-006252-cbelsymu 20 20 concerned concerned JJ cord-006252-cbelsymu 20 21 about about IN cord-006252-cbelsymu 20 22 preventing prevent VBG cord-006252-cbelsymu 20 23 it -PRON- PRP cord-006252-cbelsymu 20 24 . . . cord-006252-cbelsymu 21 1 In in IN cord-006252-cbelsymu 21 2 the the DT cord-006252-cbelsymu 21 3 United United NNP cord-006252-cbelsymu 21 4 States States NNP cord-006252-cbelsymu 21 5 alone alone RB cord-006252-cbelsymu 21 6 more more JJR cord-006252-cbelsymu 21 7 than than IN cord-006252-cbelsymu 21 8 10 10 CD cord-006252-cbelsymu 21 9 000 000 CD cord-006252-cbelsymu 21 10 deaths death NNS cord-006252-cbelsymu 21 11 are be VBP cord-006252-cbelsymu 21 12 attributed attribute VBN cord-006252-cbelsymu 21 13 to to IN cord-006252-cbelsymu 21 14 influenza influenza NN cord-006252-cbelsymu 21 15 virus virus NN cord-006252-cbelsymu 21 16 in in IN cord-006252-cbelsymu 21 17 an an DT cord-006252-cbelsymu 21 18 average average JJ cord-006252-cbelsymu 21 19 epidemic epidemic NN cord-006252-cbelsymu 21 20 year year NN cord-006252-cbelsymu 21 21 ( ( -LRB- cord-006252-cbelsymu 21 22 Recommendations Recommendations NNPS cord-006252-cbelsymu 21 23 of of IN cord-006252-cbelsymu 21 24 the the DT cord-006252-cbelsymu 21 25 Immunization Immunization NNP cord-006252-cbelsymu 21 26 Practices Practices NNPS cord-006252-cbelsymu 21 27 Advisory Advisory NNP cord-006252-cbelsymu 21 28 Committee Committee NNP cord-006252-cbelsymu 21 29 1990 1990 CD cord-006252-cbelsymu 21 30 ) ) -RRB- cord-006252-cbelsymu 21 31 . . . cord-006252-cbelsymu 22 1 In in IN cord-006252-cbelsymu 22 2 some some DT cord-006252-cbelsymu 22 3 epidemics epidemic NNS cord-006252-cbelsymu 22 4 , , , cord-006252-cbelsymu 22 5 the the DT cord-006252-cbelsymu 22 6 death death NN cord-006252-cbelsymu 22 7 toll toll NN cord-006252-cbelsymu 22 8 has have VBZ cord-006252-cbelsymu 22 9 risen rise VBN cord-006252-cbelsymu 22 10 to to IN cord-006252-cbelsymu 22 11 more more JJR cord-006252-cbelsymu 22 12 than than IN cord-006252-cbelsymu 22 13 40 40 CD cord-006252-cbelsymu 22 14 ODD odd JJ cord-006252-cbelsymu 22 15 . . . cord-006252-cbelsymu 23 1 The the DT cord-006252-cbelsymu 23 2 majority majority NN cord-006252-cbelsymu 23 3 of of IN cord-006252-cbelsymu 23 4 deaths death NNS cord-006252-cbelsymu 23 5 -80 -80 NNP cord-006252-cbelsymu 23 6 to to IN cord-006252-cbelsymu 23 7 90 90 CD cord-006252-cbelsymu 23 8 % % NN cord-006252-cbelsymu 23 9 -occur -occur HYPH cord-006252-cbelsymu 23 10 in in IN cord-006252-cbelsymu 23 11 persons person NNS cord-006252-cbelsymu 23 12 65 65 CD cord-006252-cbelsymu 23 13 years year NNS cord-006252-cbelsymu 23 14 of of IN cord-006252-cbelsymu 23 15 age age NN cord-006252-cbelsymu 23 16 and and CC cord-006252-cbelsymu 23 17 older old JJR cord-006252-cbelsymu 23 18 . . . cord-006252-cbelsymu 24 1 The the DT cord-006252-cbelsymu 24 2 estimated estimate VBN cord-006252-cbelsymu 24 3 economic economic JJ cord-006252-cbelsymu 24 4 loss loss NN cord-006252-cbelsymu 24 5 from from IN cord-006252-cbelsymu 24 6 influenza influenza NN cord-006252-cbelsymu 24 7 in in IN cord-006252-cbelsymu 24 8 the the DT cord-006252-cbelsymu 24 9 United United NNP cord-006252-cbelsymu 24 10 States States NNP cord-006252-cbelsymu 24 11 is be VBZ cord-006252-cbelsymu 24 12 estimated estimate VBN cord-006252-cbelsymu 24 13 to to TO cord-006252-cbelsymu 24 14 be be VB cord-006252-cbelsymu 24 15 more more JJR cord-006252-cbelsymu 24 16 than than IN cord-006252-cbelsymu 24 17 _SP cord-006252-cbelsymu 24 18 Influenza Influenza NNP cord-006252-cbelsymu 24 19 is be VBZ cord-006252-cbelsymu 24 20 a a DT cord-006252-cbelsymu 24 21 major major JJ cord-006252-cbelsymu 24 22 cause cause NN cord-006252-cbelsymu 24 23 of of IN cord-006252-cbelsymu 24 24 morbidity morbidity NN cord-006252-cbelsymu 24 25 and and CC cord-006252-cbelsymu 24 26 mortality mortality NN cord-006252-cbelsymu 24 27 in in IN cord-006252-cbelsymu 24 28 the the DT cord-006252-cbelsymu 24 29 elderly elderly JJ cord-006252-cbelsymu 24 30 . . . cord-006252-cbelsymu 25 1 Influenza influenza NN cord-006252-cbelsymu 25 2 vaccine vaccine NN cord-006252-cbelsymu 25 3 is be VBZ cord-006252-cbelsymu 25 4 recommended recommend VBN cord-006252-cbelsymu 25 5 for for IN cord-006252-cbelsymu 25 6 people people NNS cord-006252-cbelsymu 25 7 aged age VBN cord-006252-cbelsymu 25 8 65 65 CD cord-006252-cbelsymu 25 9 years year NNS cord-006252-cbelsymu 25 10 and and CC cord-006252-cbelsymu 25 11 older old JJR cord-006252-cbelsymu 25 12 and and CC cord-006252-cbelsymu 25 13 those those DT cord-006252-cbelsymu 25 14 in in IN cord-006252-cbelsymu 25 15 long long JJ cord-006252-cbelsymu 25 16 term term NN cord-006252-cbelsymu 25 17 care care NN cord-006252-cbelsymu 25 18 . . . cord-006252-cbelsymu 26 1 Currently currently RB cord-006252-cbelsymu 26 2 only only RB cord-006252-cbelsymu 26 3 30 30 CD cord-006252-cbelsymu 26 4 % % NN cord-006252-cbelsymu 26 5 of of IN cord-006252-cbelsymu 26 6 high high JJ cord-006252-cbelsymu 26 7 risk risk NN cord-006252-cbelsymu 26 8 persons person NNS cord-006252-cbelsymu 26 9 are be VBP cord-006252-cbelsymu 26 10 vaccinated vaccinate VBN cord-006252-cbelsymu 26 11 . . . cord-006252-cbelsymu 27 1 Vaccination vaccination NN cord-006252-cbelsymu 27 2 generally generally RB cord-006252-cbelsymu 27 3 stimulates stimulate VBZ cord-006252-cbelsymu 27 4 an an DT cord-006252-cbelsymu 27 5 adequate adequate JJ cord-006252-cbelsymu 27 6 immune immune JJ cord-006252-cbelsymu 27 7 response response NN cord-006252-cbelsymu 27 8 , , , cord-006252-cbelsymu 27 9 is be VBZ cord-006252-cbelsymu 27 10 well well RB cord-006252-cbelsymu 27 11 tolerated tolerate VBN cord-006252-cbelsymu 27 12 and and CC cord-006252-cbelsymu 27 13 is be VBZ cord-006252-cbelsymu 27 14 to to TO cord-006252-cbelsymu 27 15 be be VB cord-006252-cbelsymu 27 16 encouraged encourage VBN cord-006252-cbelsymu 27 17 . . . cord-006252-cbelsymu 28 1 Prophylactic prophylactic JJ cord-006252-cbelsymu 28 2 amantadine amantadine NNP cord-006252-cbelsymu 28 3 100 100 CD cord-006252-cbelsymu 28 4 mg mg NNP cord-006252-cbelsymu 28 5 / / SYM cord-006252-cbelsymu 28 6 day day NN cord-006252-cbelsymu 28 7 should should MD cord-006252-cbelsymu 28 8 be be VB cord-006252-cbelsymu 28 9 given give VBN cord-006252-cbelsymu 28 10 for for IN cord-006252-cbelsymu 28 11 2 2 CD cord-006252-cbelsymu 28 12 weeks week NNS cord-006252-cbelsymu 28 13 with with IN cord-006252-cbelsymu 28 14 influenza influenza NN cord-006252-cbelsymu 28 15 vaccine vaccine NN cord-006252-cbelsymu 28 16 in in IN cord-006252-cbelsymu 28 17 the the DT cord-006252-cbelsymu 28 18 aged aged JJ cord-006252-cbelsymu 28 19 population population NN cord-006252-cbelsymu 28 20 when when WRB cord-006252-cbelsymu 28 21 they -PRON- PRP cord-006252-cbelsymu 28 22 have have VBP cord-006252-cbelsymu 28 23 not not RB cord-006252-cbelsymu 28 24 been be VBN cord-006252-cbelsymu 28 25 previously previously RB cord-006252-cbelsymu 28 26 immunised immunise VBN cord-006252-cbelsymu 28 27 . . . cord-006252-cbelsymu 29 1 Broad broad JJ cord-006252-cbelsymu 29 2 application application NN cord-006252-cbelsymu 29 3 of of IN cord-006252-cbelsymu 29 4 these these DT cord-006252-cbelsymu 29 5 preventive preventive JJ cord-006252-cbelsymu 29 6 measures measure NNS cord-006252-cbelsymu 29 7 would would MD cord-006252-cbelsymu 29 8 have have VB cord-006252-cbelsymu 29 9 a a DT cord-006252-cbelsymu 29 10 significant significant JJ cord-006252-cbelsymu 29 11 impact impact NN cord-006252-cbelsymu 29 12 on on IN cord-006252-cbelsymu 29 13 reducing reduce VBG cord-006252-cbelsymu 29 14 influenza influenza NN cord-006252-cbelsymu 29 15 prevalence prevalence NN cord-006252-cbelsymu 29 16 in in IN cord-006252-cbelsymu 29 17 the the DT cord-006252-cbelsymu 29 18 elderly elderly JJ cord-006252-cbelsymu 29 19 and and CC cord-006252-cbelsymu 29 20 other other JJ cord-006252-cbelsymu 29 21 high high JJ cord-006252-cbelsymu 29 22 risk risk NN cord-006252-cbelsymu 29 23 groups group NNS cord-006252-cbelsymu 29 24 . . . cord-006252-cbelsymu 30 1 If if IN cord-006252-cbelsymu 30 2 we -PRON- PRP cord-006252-cbelsymu 30 3 were be VBD cord-006252-cbelsymu 30 4 more more RBR cord-006252-cbelsymu 30 5 aware aware JJ cord-006252-cbelsymu 30 6 of of IN cord-006252-cbelsymu 30 7 the the DT cord-006252-cbelsymu 30 8 full full JJ cord-006252-cbelsymu 30 9 impact impact NN cord-006252-cbelsymu 30 10 of of IN cord-006252-cbelsymu 30 11 influenza influenza NN cord-006252-cbelsymu 30 12 on on IN cord-006252-cbelsymu 30 13 our -PRON- PRP$ cord-006252-cbelsymu 30 14 lives life NNS cord-006252-cbelsymu 30 15 , , , cord-006252-cbelsymu 30 16 we -PRON- PRP cord-006252-cbelsymu 30 17 would would MD cord-006252-cbelsymu 30 18 be be VB cord-006252-cbelsymu 30 19 more more RBR cord-006252-cbelsymu 30 20 concerned concerned JJ cord-006252-cbelsymu 30 21 about about IN cord-006252-cbelsymu 30 22 preventing prevent VBG cord-006252-cbelsymu 30 23 it -PRON- PRP cord-006252-cbelsymu 30 24 . . . cord-006252-cbelsymu 31 1 In in IN cord-006252-cbelsymu 31 2 the the DT cord-006252-cbelsymu 31 3 United United NNP cord-006252-cbelsymu 31 4 States States NNP cord-006252-cbelsymu 31 5 alone alone RB cord-006252-cbelsymu 31 6 more more JJR cord-006252-cbelsymu 31 7 than than IN cord-006252-cbelsymu 31 8 10 10 CD cord-006252-cbelsymu 31 9 000 000 CD cord-006252-cbelsymu 31 10 deaths death NNS cord-006252-cbelsymu 31 11 are be VBP cord-006252-cbelsymu 31 12 attributed attribute VBN cord-006252-cbelsymu 31 13 to to IN cord-006252-cbelsymu 31 14 influenza influenza NN cord-006252-cbelsymu 31 15 virus virus NN cord-006252-cbelsymu 31 16 in in IN cord-006252-cbelsymu 31 17 an an DT cord-006252-cbelsymu 31 18 average average JJ cord-006252-cbelsymu 31 19 epidemic epidemic NN cord-006252-cbelsymu 31 20 year year NN cord-006252-cbelsymu 31 21 ( ( -LRB- cord-006252-cbelsymu 31 22 Recommendations Recommendations NNPS cord-006252-cbelsymu 31 23 of of IN cord-006252-cbelsymu 31 24 the the DT cord-006252-cbelsymu 31 25 Immunization Immunization NNP cord-006252-cbelsymu 31 26 Practices Practices NNPS cord-006252-cbelsymu 31 27 Advisory Advisory NNP cord-006252-cbelsymu 31 28 Committee Committee NNP cord-006252-cbelsymu 31 29 1990 1990 CD cord-006252-cbelsymu 31 30 ) ) -RRB- cord-006252-cbelsymu 31 31 . . . cord-006252-cbelsymu 32 1 In in IN cord-006252-cbelsymu 32 2 some some DT cord-006252-cbelsymu 32 3 epidemics epidemic NNS cord-006252-cbelsymu 32 4 , , , cord-006252-cbelsymu 32 5 the the DT cord-006252-cbelsymu 32 6 death death NN cord-006252-cbelsymu 32 7 toll toll NN cord-006252-cbelsymu 32 8 has have VBZ cord-006252-cbelsymu 32 9 risen rise VBN cord-006252-cbelsymu 32 10 to to IN cord-006252-cbelsymu 32 11 more more JJR cord-006252-cbelsymu 32 12 than than IN cord-006252-cbelsymu 32 13 40 40 CD cord-006252-cbelsymu 32 14 ODD odd JJ cord-006252-cbelsymu 32 15 . . . cord-006252-cbelsymu 33 1 The the DT cord-006252-cbelsymu 33 2 majority majority NN cord-006252-cbelsymu 33 3 of of IN cord-006252-cbelsymu 33 4 deaths death NNS cord-006252-cbelsymu 33 5 -80 -80 NNP cord-006252-cbelsymu 33 6 to to IN cord-006252-cbelsymu 33 7 90 90 CD cord-006252-cbelsymu 33 8 % % NN cord-006252-cbelsymu 33 9 -occur -occur HYPH cord-006252-cbelsymu 33 10 in in IN cord-006252-cbelsymu 33 11 persons person NNS cord-006252-cbelsymu 33 12 65 65 CD cord-006252-cbelsymu 33 13 years year NNS cord-006252-cbelsymu 33 14 of of IN cord-006252-cbelsymu 33 15 age age NN cord-006252-cbelsymu 33 16 and and CC cord-006252-cbelsymu 33 17 older old JJR cord-006252-cbelsymu 33 18 . . . cord-006252-cbelsymu 34 1 The the DT cord-006252-cbelsymu 34 2 estimated estimate VBN cord-006252-cbelsymu 34 3 economic economic JJ cord-006252-cbelsymu 34 4 loss loss NN cord-006252-cbelsymu 34 5 from from IN cord-006252-cbelsymu 34 6 influenza influenza NN cord-006252-cbelsymu 34 7 in in IN cord-006252-cbelsymu 34 8 the the DT cord-006252-cbelsymu 34 9 United United NNP cord-006252-cbelsymu 34 10 States States NNP cord-006252-cbelsymu 34 11 is be VBZ cord-006252-cbelsymu 34 12 estimated estimate VBN cord-006252-cbelsymu 34 13 to to TO cord-006252-cbelsymu 34 14 be be VB cord-006252-cbelsymu 34 15 more more JJR cord-006252-cbelsymu 34 16 than than IN cord-006252-cbelsymu 34 17 $ $ $ cord-006252-cbelsymu 34 18 USI USI NNP cord-006252-cbelsymu 34 19 billion billion CD cord-006252-cbelsymu 34 20 each each DT cord-006252-cbelsymu 34 21 year year NN cord-006252-cbelsymu 34 22 ( ( -LRB- cord-006252-cbelsymu 34 23 Schoenbaum Schoenbaum NNP cord-006252-cbelsymu 34 24 1987 1987 CD cord-006252-cbelsymu 34 25 ) ) -RRB- cord-006252-cbelsymu 34 26 . . . cord-006252-cbelsymu 35 1 In in IN cord-006252-cbelsymu 35 2 reality reality NN cord-006252-cbelsymu 35 3 , , , cord-006252-cbelsymu 35 4 the the DT cord-006252-cbelsymu 35 5 cost cost NN cord-006252-cbelsymu 35 6 is be VBZ cord-006252-cbelsymu 35 7 probably probably RB cord-006252-cbelsymu 35 8 3 3 CD cord-006252-cbelsymu 35 9 to to TO cord-006252-cbelsymu 35 10 5 5 CD cord-006252-cbelsymu 35 11 times time NNS cord-006252-cbelsymu 35 12 greater great JJR cord-006252-cbelsymu 35 13 . . . cord-006252-cbelsymu 36 1 While while IN cord-006252-cbelsymu 36 2 much much JJ cord-006252-cbelsymu 36 3 has have VBZ cord-006252-cbelsymu 36 4 been be VBN cord-006252-cbelsymu 36 5 written write VBN cord-006252-cbelsymu 36 6 on on IN cord-006252-cbelsymu 36 7 the the DT cord-006252-cbelsymu 36 8 cost cost NN cord-006252-cbelsymu 36 9 - - HYPH cord-006252-cbelsymu 36 10 benefit benefit NN cord-006252-cbelsymu 36 11 ratio ratio NN cord-006252-cbelsymu 36 12 for for IN cord-006252-cbelsymu 36 13 influenza influenza NN cord-006252-cbelsymu 36 14 vaccine vaccine NN cord-006252-cbelsymu 36 15 , , , cord-006252-cbelsymu 36 16 in in IN cord-006252-cbelsymu 36 17 persons person NNS cord-006252-cbelsymu 36 18 65 65 CD cord-006252-cbelsymu 36 19 years year NNS cord-006252-cbelsymu 36 20 of of IN cord-006252-cbelsymu 36 21 age age NN cord-006252-cbelsymu 36 22 and and CC cord-006252-cbelsymu 36 23 above above IN cord-006252-cbelsymu 36 24 the the DT cord-006252-cbelsymu 36 25 benefit benefit NN cord-006252-cbelsymu 36 26 clearly clearly RB cord-006252-cbelsymu 36 27 outweighs outweigh VBZ cord-006252-cbelsymu 36 28 the the DT cord-006252-cbelsymu 36 29 cost cost NN cord-006252-cbelsymu 36 30 . . . cord-006252-cbelsymu 37 1 Despite despite IN cord-006252-cbelsymu 37 2 the the DT cord-006252-cbelsymu 37 3 favourable favourable JJ cord-006252-cbelsymu 37 4 impression impression NN cord-006252-cbelsymu 37 5 gained gain VBN cord-006252-cbelsymu 37 6 from from IN cord-006252-cbelsymu 37 7 economic economic JJ cord-006252-cbelsymu 37 8 models model NNS cord-006252-cbelsymu 37 9 , , , cord-006252-cbelsymu 37 10 however however RB cord-006252-cbelsymu 37 11 , , , cord-006252-cbelsymu 37 12 individual individual JJ cord-006252-cbelsymu 37 13 patients patient NNS cord-006252-cbelsymu 37 14 and and CC cord-006252-cbelsymu 37 15 their -PRON- PRP$ cord-006252-cbelsymu 37 16 physicians physician NNS cord-006252-cbelsymu 37 17 do do VBP cord-006252-cbelsymu 37 18 not not RB cord-006252-cbelsymu 37 19 as as IN cord-006252-cbelsymu 37 20 a a DT cord-006252-cbelsymu 37 21 rule rule NN cord-006252-cbelsymu 37 22 perceive perceive VBP cord-006252-cbelsymu 37 23 the the DT cord-006252-cbelsymu 37 24 benefit benefit NN cord-006252-cbelsymu 37 25 . . . cord-006252-cbelsymu 38 1 As as IN cord-006252-cbelsymu 38 2 a a DT cord-006252-cbelsymu 38 3 result result NN cord-006252-cbelsymu 38 4 , , , cord-006252-cbelsymu 38 5 only only RB cord-006252-cbelsymu 38 6 a a DT cord-006252-cbelsymu 38 7 small small JJ cord-006252-cbelsymu 38 8 percentage percentage NN cord-006252-cbelsymu 38 9 of of IN cord-006252-cbelsymu 38 10 the the DT cord-006252-cbelsymu 38 11 elderly elderly JJ cord-006252-cbelsymu 38 12 population population NN cord-006252-cbelsymu 38 13 are be VBP cord-006252-cbelsymu 38 14 vaccinated vaccinate VBN cord-006252-cbelsymu 38 15 each each DT cord-006252-cbelsymu 38 16 year year NN cord-006252-cbelsymu 38 17 . . . cord-006252-cbelsymu 39 1 What what WP cord-006252-cbelsymu 39 2 is be VBZ cord-006252-cbelsymu 39 3 influenza influenza JJ cord-006252-cbelsymu 39 4 ? ? . cord-006252-cbelsymu 40 1 Is be VBZ cord-006252-cbelsymu 40 2 it -PRON- PRP cord-006252-cbelsymu 40 3 easy easy JJ cord-006252-cbelsymu 40 4 to to TO cord-006252-cbelsymu 40 5 diagnose diagnose VB cord-006252-cbelsymu 40 6 ? ? . cord-006252-cbelsymu 41 1 How how WRB cord-006252-cbelsymu 41 2 effective effective JJ cord-006252-cbelsymu 41 3 is be VBZ cord-006252-cbelsymu 41 4 influenza influenza JJ cord-006252-cbelsymu 41 5 vaccine vaccine NN cord-006252-cbelsymu 41 6 ? ? . cord-006252-cbelsymu 42 1 Are be VBP cord-006252-cbelsymu 42 2 the the DT cord-006252-cbelsymu 42 3 side side NN cord-006252-cbelsymu 42 4 effects effect VBZ cord-006252-cbelsymu 42 5 a a DT cord-006252-cbelsymu 42 6 frequent frequent JJ cord-006252-cbelsymu 42 7 concern concern NN cord-006252-cbelsymu 42 8 ? ? . cord-006252-cbelsymu 43 1 What what WDT cord-006252-cbelsymu 43 2 efforts effort NNS cord-006252-cbelsymu 43 3 have have VBP cord-006252-cbelsymu 43 4 been be VBN cord-006252-cbelsymu 43 5 and and CC cord-006252-cbelsymu 43 6 can can MD cord-006252-cbelsymu 43 7 be be VB cord-006252-cbelsymu 43 8 made make VBN cord-006252-cbelsymu 43 9 to to TO cord-006252-cbelsymu 43 10 improve improve VB cord-006252-cbelsymu 43 11 vaccine vaccine NN cord-006252-cbelsymu 43 12 acceptance acceptance NN cord-006252-cbelsymu 43 13 ? ? . cord-006252-cbelsymu 44 1 These these DT cord-006252-cbelsymu 44 2 are be VBP cord-006252-cbelsymu 44 3 some some DT cord-006252-cbelsymu 44 4 of of IN cord-006252-cbelsymu 44 5 the the DT cord-006252-cbelsymu 44 6 important important JJ cord-006252-cbelsymu 44 7 questions question NNS cord-006252-cbelsymu 44 8 we -PRON- PRP cord-006252-cbelsymu 44 9 attempt attempt VBP cord-006252-cbelsymu 44 10 to to TO cord-006252-cbelsymu 44 11 answer answer VB cord-006252-cbelsymu 44 12 in in IN cord-006252-cbelsymu 44 13 this this DT cord-006252-cbelsymu 44 14 article article NN cord-006252-cbelsymu 44 15 . . . cord-006252-cbelsymu 45 1 I -PRON- PRP cord-006252-cbelsymu 46 1 Influenza influenza NN cord-006252-cbelsymu 46 2 virus virus NN cord-006252-cbelsymu 46 3 was be VBD cord-006252-cbelsymu 46 4 first first RB cord-006252-cbelsymu 46 5 isolated isolate VBN cord-006252-cbelsymu 46 6 from from IN cord-006252-cbelsymu 46 7 humans human NNS cord-006252-cbelsymu 46 8 in in IN cord-006252-cbelsymu 46 9 the the DT cord-006252-cbelsymu 46 10 1930s 1930 NNS cord-006252-cbelsymu 46 11 ( ( -LRB- cord-006252-cbelsymu 46 12 Ruben Ruben NNP cord-006252-cbelsymu 46 13 1987 1987 CD cord-006252-cbelsymu 46 14 ) ) -RRB- cord-006252-cbelsymu 46 15 . . . cord-006252-cbelsymu 47 1 The the DT cord-006252-cbelsymu 47 2 clinical clinical JJ cord-006252-cbelsymu 47 3 syndrome syndrome NN cord-006252-cbelsymu 47 4 of of IN cord-006252-cbelsymu 47 5 a a DT cord-006252-cbelsymu 47 6 typical typical JJ cord-006252-cbelsymu 47 7 case case NN cord-006252-cbelsymu 47 8 of of IN cord-006252-cbelsymu 47 9 influenza influenza NN cord-006252-cbelsymu 47 10 begins begin VBZ cord-006252-cbelsymu 47 11 with with IN cord-006252-cbelsymu 47 12 fever fever NN cord-006252-cbelsymu 47 13 , , , cord-006252-cbelsymu 47 14 cough cough NN cord-006252-cbelsymu 47 15 and and CC cord-006252-cbelsymu 47 16 myalgias myalgia NNS cord-006252-cbelsymu 47 17 that that WDT cord-006252-cbelsymu 47 18 last last VBD cord-006252-cbelsymu 47 19 for for IN cord-006252-cbelsymu 47 20 a a DT cord-006252-cbelsymu 47 21 few few JJ cord-006252-cbelsymu 47 22 days day NNS cord-006252-cbelsymu 47 23 to to IN cord-006252-cbelsymu 47 24 a a DT cord-006252-cbelsymu 47 25 week week NN cord-006252-cbelsymu 47 26 . . . cord-006252-cbelsymu 48 1 The the DT cord-006252-cbelsymu 48 2 clinical clinical JJ cord-006252-cbelsymu 48 3 course course NN cord-006252-cbelsymu 48 4 may may MD cord-006252-cbelsymu 48 5 be be VB cord-006252-cbelsymu 48 6 complicated complicate VBN cord-006252-cbelsymu 48 7 by by IN cord-006252-cbelsymu 48 8 laryngotracheobronchitis laryngotracheobronchitis NNP cord-006252-cbelsymu 48 9 and and CC cord-006252-cbelsymu 48 10 pneumonia pneumonia NN cord-006252-cbelsymu 48 11 . . . cord-006252-cbelsymu 49 1 Secondary secondary JJ cord-006252-cbelsymu 49 2 bacterial bacterial JJ cord-006252-cbelsymu 49 3 pneumonia pneumonia NN cord-006252-cbelsymu 49 4 may may MD cord-006252-cbelsymu 49 5 occur occur VB cord-006252-cbelsymu 49 6 simultaneously simultaneously RB cord-006252-cbelsymu 49 7 or or CC cord-006252-cbelsymu 49 8 a a DT cord-006252-cbelsymu 49 9 few few JJ cord-006252-cbelsymu 49 10 days day NNS cord-006252-cbelsymu 49 11 later later RB cord-006252-cbelsymu 49 12 . . . cord-006252-cbelsymu 50 1 Hospitalisation hospitalisation NN cord-006252-cbelsymu 50 2 is be VBZ cord-006252-cbelsymu 50 3 more more RBR cord-006252-cbelsymu 50 4 likely likely JJ cord-006252-cbelsymu 50 5 to to TO cord-006252-cbelsymu 50 6 occur occur VB cord-006252-cbelsymu 50 7 in in IN cord-006252-cbelsymu 50 8 individuals individual NNS cord-006252-cbelsymu 50 9 who who WP cord-006252-cbelsymu 50 10 are be VBP cord-006252-cbelsymu 50 11 elderly elderly JJ cord-006252-cbelsymu 50 12 or or CC cord-006252-cbelsymu 50 13 have have VBP cord-006252-cbelsymu 50 14 pre pre VBN cord-006252-cbelsymu 50 15 - - JJ cord-006252-cbelsymu 50 16 existing existing JJ cord-006252-cbelsymu 50 17 cardiac cardiac JJ cord-006252-cbelsymu 50 18 or or CC cord-006252-cbelsymu 50 19 pulmonary pulmonary JJ cord-006252-cbelsymu 50 20 disease disease NN cord-006252-cbelsymu 50 21 . . . cord-006252-cbelsymu 51 1 Children child NNS cord-006252-cbelsymu 51 2 aged age VBN cord-006252-cbelsymu 51 3 under under IN cord-006252-cbelsymu 51 4 12 12 CD cord-006252-cbelsymu 51 5 years year NNS cord-006252-cbelsymu 51 6 taking take VBG cord-006252-cbelsymu 51 7 aspirin aspirin NN cord-006252-cbelsymu 51 8 during during IN cord-006252-cbelsymu 51 9 the the DT cord-006252-cbelsymu 51 10 early early JJ cord-006252-cbelsymu 51 11 phases phase NNS cord-006252-cbelsymu 51 12 of of IN cord-006252-cbelsymu 51 13 infection infection NN cord-006252-cbelsymu 51 14 are be VBP cord-006252-cbelsymu 51 15 more more RBR cord-006252-cbelsymu 51 16 likely likely JJ cord-006252-cbelsymu 51 17 to to TO cord-006252-cbelsymu 51 18 get get VB cord-006252-cbelsymu 51 19 Reye Reye NNP cord-006252-cbelsymu 51 20 's 's POS cord-006252-cbelsymu 51 21 syndrome syndrome NN cord-006252-cbelsymu 51 22 . . . cord-006252-cbelsymu 52 1 Late late JJ cord-006252-cbelsymu 52 2 complications complication NNS cord-006252-cbelsymu 52 3 of of IN cord-006252-cbelsymu 52 4 infection infection NN cord-006252-cbelsymu 52 5 such such JJ cord-006252-cbelsymu 52 6 as as IN cord-006252-cbelsymu 52 7 fatigue fatigue NN cord-006252-cbelsymu 52 8 , , , cord-006252-cbelsymu 52 9 chronic chronic JJ cord-006252-cbelsymu 52 10 cough cough NN cord-006252-cbelsymu 52 11 , , , cord-006252-cbelsymu 52 12 and and CC cord-006252-cbelsymu 52 13 small small JJ cord-006252-cbelsymu 52 14 - - HYPH cord-006252-cbelsymu 52 15 airway airway NN cord-006252-cbelsymu 52 16 disease disease NN cord-006252-cbelsymu 52 17 may may MD cord-006252-cbelsymu 52 18 last last VB cord-006252-cbelsymu 52 19 for for IN cord-006252-cbelsymu 52 20 weeks week NNS cord-006252-cbelsymu 52 21 . . . cord-006252-cbelsymu 53 1 Making make VBG cord-006252-cbelsymu 53 2 a a DT cord-006252-cbelsymu 53 3 diagnosis diagnosis NN cord-006252-cbelsymu 53 4 of of IN cord-006252-cbelsymu 53 5 influenza influenza NN cord-006252-cbelsymu 53 6 virus virus NN cord-006252-cbelsymu 53 7 infection infection NN cord-006252-cbelsymu 53 8 is be VBZ cord-006252-cbelsymu 53 9 difficult difficult JJ cord-006252-cbelsymu 53 10 because because IN cord-006252-cbelsymu 53 11 the the DT cord-006252-cbelsymu 53 12 acute acute JJ cord-006252-cbelsymu 53 13 respiratory respiratory JJ cord-006252-cbelsymu 53 14 syndromes syndrome NNS cord-006252-cbelsymu 53 15 may may MD cord-006252-cbelsymu 53 16 be be VB cord-006252-cbelsymu 53 17 confused confuse VBN cord-006252-cbelsymu 53 18 with with IN cord-006252-cbelsymu 53 19 other other JJ cord-006252-cbelsymu 53 20 viral viral JJ cord-006252-cbelsymu 53 21 respiratory respiratory JJ cord-006252-cbelsymu 53 22 agents agent NNS cord-006252-cbelsymu 53 23 such such JJ cord-006252-cbelsymu 53 24 as as IN cord-006252-cbelsymu 53 25 parainfluenza parainfluenza NNP cord-006252-cbelsymu 53 26 viruses virus NNS cord-006252-cbelsymu 53 27 , , , cord-006252-cbelsymu 53 28 adenoviruses adenovirus NNS cord-006252-cbelsymu 53 29 , , , cord-006252-cbelsymu 53 30 respiratory respiratory JJ cord-006252-cbelsymu 53 31 syncytial syncytial JJ cord-006252-cbelsymu 53 32 viruses virus NNS cord-006252-cbelsymu 53 33 as as RB cord-006252-cbelsymu 53 34 well well RB cord-006252-cbelsymu 53 35 as as IN cord-006252-cbelsymu 53 36 the the DT cord-006252-cbelsymu 53 37 more more RBR cord-006252-cbelsymu 53 38 common common JJ cord-006252-cbelsymu 53 39 rhinoviruses rhinovirus NNS cord-006252-cbelsymu 53 40 and and CC cord-006252-cbelsymu 53 41 coronaviruses coronaviruse NNS cord-006252-cbelsymu 53 42 . . . cord-006252-cbelsymu 54 1 Laboratory laboratory NN cord-006252-cbelsymu 54 2 I i CD cord-006252-cbelsymu 55 1 Educational educational JJ cord-006252-cbelsymu 55 2 materials material NNS cord-006252-cbelsymu 55 3 on on IN cord-006252-cbelsymu 55 4 influenza influenza NN cord-006252-cbelsymu 55 5 are be VBP cord-006252-cbelsymu 55 6 available available JJ cord-006252-cbelsymu 55 7 from from IN cord-006252-cbelsymu 55 8 the the DT cord-006252-cbelsymu 55 9 Centers Centers NNPS cord-006252-cbelsymu 55 10 for for IN cord-006252-cbelsymu 55 11 Disease Disease NNP cord-006252-cbelsymu 55 12 Control Control NNP cord-006252-cbelsymu 56 1 [ [ -LRB- cord-006252-cbelsymu 56 2 Technical Technical NNP cord-006252-cbelsymu 56 3 Information Information NNP cord-006252-cbelsymu 56 4 Services Services NNP cord-006252-cbelsymu 56 5 , , , cord-006252-cbelsymu 56 6 Center Center NNP cord-006252-cbelsymu 56 7 for for IN cord-006252-cbelsymu 56 8 Prevention Prevention NNP cord-006252-cbelsymu 56 9 Services Services NNPS cord-006252-cbelsymu 56 10 , , , cord-006252-cbelsymu 56 11 Mailstop Mailstop NNP cord-006252-cbelsymu 56 12 E06 E06 NNP cord-006252-cbelsymu 56 13 , , , cord-006252-cbelsymu 56 14 CDC CDC NNP cord-006252-cbelsymu 56 15 , , , cord-006252-cbelsymu 56 16 Atlanta Atlanta NNP cord-006252-cbelsymu 56 17 , , , cord-006252-cbelsymu 56 18 GA GA NNP cord-006252-cbelsymu 56 19 30333 30333 CD cord-006252-cbelsymu 56 20 , , , cord-006252-cbelsymu 56 21 USA USA NNP cord-006252-cbelsymu 56 22 ; ; , cord-006252-cbelsymu 56 23 phone phone NN cord-006252-cbelsymu 56 24 ( ( -LRB- cord-006252-cbelsymu 56 25 404 404 CD cord-006252-cbelsymu 56 26 ) ) -RRB- cord-006252-cbelsymu 56 27 639 639 CD cord-006252-cbelsymu 56 28 - - SYM cord-006252-cbelsymu 56 29 18191 18191 CD cord-006252-cbelsymu 56 30 as as RB cord-006252-cbelsymu 56 31 well well RB cord-006252-cbelsymu 56 32 as as IN cord-006252-cbelsymu 56 33 from from IN cord-006252-cbelsymu 56 34 state state NN cord-006252-cbelsymu 56 35 and and CC cord-006252-cbelsymu 56 36 local local JJ cord-006252-cbelsymu 56 37 health health NN cord-006252-cbelsymu 56 38 departments department NNS cord-006252-cbelsymu 56 39 in in IN cord-006252-cbelsymu 56 40 the the DT cord-006252-cbelsymu 56 41 USA USA NNP cord-006252-cbelsymu 56 42 . . . cord-006252-cbelsymu 57 1 Drugs drug NNS cord-006252-cbelsymu 57 2 & & CC cord-006252-cbelsymu 57 3 Aging Aging NNP cord-006252-cbelsymu 57 4 1 1 CD cord-006252-cbelsymu 57 5 ( ( -LRB- cord-006252-cbelsymu 57 6 6 6 CD cord-006252-cbelsymu 57 7 ) ) -RRB- cord-006252-cbelsymu 57 8 1991 1991 CD cord-006252-cbelsymu 57 9 tests test NNS cord-006252-cbelsymu 57 10 can can MD cord-006252-cbelsymu 57 11 distinguish distinguish VB cord-006252-cbelsymu 57 12 among among IN cord-006252-cbelsymu 57 13 these these DT cord-006252-cbelsymu 57 14 agents agent NNS cord-006252-cbelsymu 57 15 , , , cord-006252-cbelsymu 57 16 and and CC cord-006252-cbelsymu 57 17 rapid rapid JJ cord-006252-cbelsymu 57 18 , , , cord-006252-cbelsymu 57 19 sensitive sensitive JJ cord-006252-cbelsymu 57 20 tests test NNS cord-006252-cbelsymu 57 21 are be VBP cord-006252-cbelsymu 57 22 now now RB cord-006252-cbelsymu 57 23 available available JJ cord-006252-cbelsymu 57 24 to to TO cord-006252-cbelsymu 57 25 diagnose diagnose VB cord-006252-cbelsymu 57 26 influenza influenza NN cord-006252-cbelsymu 57 27 virus virus NN cord-006252-cbelsymu 57 28 ( ( -LRB- cord-006252-cbelsymu 57 29 Reichelderfer Reichelderfer NNP cord-006252-cbelsymu 57 30 et et FW cord-006252-cbelsymu 57 31 al al NNP cord-006252-cbelsymu 57 32 . . NNP cord-006252-cbelsymu 57 33 1987 1987 CD cord-006252-cbelsymu 57 34 ) ) -RRB- cord-006252-cbelsymu 57 35 . . . cord-006252-cbelsymu 58 1 A a DT cord-006252-cbelsymu 58 2 specific specific JJ cord-006252-cbelsymu 58 3 diagnosis diagnosis NN cord-006252-cbelsymu 58 4 of of IN cord-006252-cbelsymu 58 5 influenza influenza NN cord-006252-cbelsymu 58 6 can can MD cord-006252-cbelsymu 58 7 be be VB cord-006252-cbelsymu 58 8 made make VBN cord-006252-cbelsymu 58 9 in in IN cord-006252-cbelsymu 58 10 a a DT cord-006252-cbelsymu 58 11 few few JJ cord-006252-cbelsymu 58 12 hours hour NNS cord-006252-cbelsymu 58 13 to to IN cord-006252-cbelsymu 58 14 a a DT cord-006252-cbelsymu 58 15 few few JJ cord-006252-cbelsymu 58 16 days day NNS cord-006252-cbelsymu 58 17 , , , cord-006252-cbelsymu 58 18 rather rather RB cord-006252-cbelsymu 58 19 than than IN cord-006252-cbelsymu 58 20 in in IN cord-006252-cbelsymu 58 21 a a DT cord-006252-cbelsymu 58 22 week week NN cord-006252-cbelsymu 58 23 or or CC cord-006252-cbelsymu 58 24 more more JJR cord-006252-cbelsymu 58 25 as as IN cord-006252-cbelsymu 58 26 was be VBD cord-006252-cbelsymu 58 27 the the DT cord-006252-cbelsymu 58 28 case case NN cord-006252-cbelsymu 58 29 several several JJ cord-006252-cbelsymu 58 30 years year NNS cord-006252-cbelsymu 58 31 ago ago RB cord-006252-cbelsymu 58 32 . . . cord-006252-cbelsymu 59 1 While while IN cord-006252-cbelsymu 59 2 influenza influenza NN cord-006252-cbelsymu 59 3 virus virus NN cord-006252-cbelsymu 59 4 infection infection NN cord-006252-cbelsymu 59 5 may may MD cord-006252-cbelsymu 59 6 be be VB cord-006252-cbelsymu 59 7 difficult difficult JJ cord-006252-cbelsymu 59 8 to to TO cord-006252-cbelsymu 59 9 distinguish distinguish VB cord-006252-cbelsymu 59 10 from from IN cord-006252-cbelsymu 59 11 other other JJ cord-006252-cbelsymu 59 12 respiratory respiratory JJ cord-006252-cbelsymu 59 13 viruses virus NNS cord-006252-cbelsymu 59 14 on on IN cord-006252-cbelsymu 59 15 clinical clinical JJ cord-006252-cbelsymu 59 16 grounds ground NNS cord-006252-cbelsymu 59 17 , , , cord-006252-cbelsymu 59 18 influenza influenza NN cord-006252-cbelsymu 59 19 virus virus NN cord-006252-cbelsymu 59 20 is be VBZ cord-006252-cbelsymu 59 21 unique unique JJ cord-006252-cbelsymu 59 22 among among IN cord-006252-cbelsymu 59 23 the the DT cord-006252-cbelsymu 59 24 respiratory respiratory JJ cord-006252-cbelsymu 59 25 viruses virus NNS cord-006252-cbelsymu 59 26 for for IN cord-006252-cbelsymu 59 27 the the DT cord-006252-cbelsymu 59 28 high high JJ cord-006252-cbelsymu 59 29 mortality mortality NN cord-006252-cbelsymu 59 30 associated associate VBN cord-006252-cbelsymu 59 31 with with IN cord-006252-cbelsymu 59 32 it -PRON- PRP cord-006252-cbelsymu 59 33 . . . cord-006252-cbelsymu 60 1 Since since IN cord-006252-cbelsymu 60 2 the the DT cord-006252-cbelsymu 60 3 sixteenth sixteenth JJ cord-006252-cbelsymu 60 4 century century NN cord-006252-cbelsymu 60 5 , , , cord-006252-cbelsymu 60 6 people people NNS cord-006252-cbelsymu 60 7 have have VBP cord-006252-cbelsymu 60 8 recognised recognise VBN cord-006252-cbelsymu 60 9 the the DT cord-006252-cbelsymu 60 10 increased increase VBN cord-006252-cbelsymu 60 11 mortality mortality NN cord-006252-cbelsymu 60 12 resulting result VBG cord-006252-cbelsymu 60 13 from from IN cord-006252-cbelsymu 60 14 an an DT cord-006252-cbelsymu 60 15 influenza influenza NN cord-006252-cbelsymu 60 16 epidemic epidemic NN cord-006252-cbelsymu 60 17 ( ( -LRB- cord-006252-cbelsymu 60 18 Monto Monto NNP cord-006252-cbelsymu 60 19 1987 1987 CD cord-006252-cbelsymu 60 20 ) ) -RRB- cord-006252-cbelsymu 60 21 . . . cord-006252-cbelsymu 61 1 Excess excess JJ cord-006252-cbelsymu 61 2 mortality mortality NN cord-006252-cbelsymu 61 3 from from IN cord-006252-cbelsymu 61 4 influenza influenza NN cord-006252-cbelsymu 61 5 has have VBZ cord-006252-cbelsymu 61 6 been be VBN cord-006252-cbelsymu 61 7 documented document VBN cord-006252-cbelsymu 61 8 since since IN cord-006252-cbelsymu 61 9 1889 1889 CD cord-006252-cbelsymu 61 10 . . . cord-006252-cbelsymu 62 1 On on IN cord-006252-cbelsymu 62 2 occasion occasion NN cord-006252-cbelsymu 62 3 , , , cord-006252-cbelsymu 62 4 influenza influenza NN cord-006252-cbelsymu 62 5 outbreaks outbreak NNS cord-006252-cbelsymu 62 6 reach reach VBP cord-006252-cbelsymu 62 7 pandemic pandemic NN cord-006252-cbelsymu 62 8 proportions proportion NNS cord-006252-cbelsymu 62 9 , , , cord-006252-cbelsymu 62 10 as as IN cord-006252-cbelsymu 62 11 occurred occur VBN cord-006252-cbelsymu 62 12 in in IN cord-006252-cbelsymu 62 13 1918 1918 CD cord-006252-cbelsymu 62 14 . . . cord-006252-cbelsymu 63 1 Influenza influenza NN cord-006252-cbelsymu 63 2 epidemics epidemic NNS cord-006252-cbelsymu 63 3 occur occur VBP cord-006252-cbelsymu 63 4 almost almost RB cord-006252-cbelsymu 63 5 every every DT cord-006252-cbelsymu 63 6 winter winter NN cord-006252-cbelsymu 63 7 . . . cord-006252-cbelsymu 64 1 Quantifying quantify VBG cord-006252-cbelsymu 64 2 the the DT cord-006252-cbelsymu 64 3 mortality mortality NN cord-006252-cbelsymu 64 4 from from IN cord-006252-cbelsymu 64 5 influenza influenza NN cord-006252-cbelsymu 64 6 begins begin VBZ cord-006252-cbelsymu 64 7 with with IN cord-006252-cbelsymu 64 8 describing describe VBG cord-006252-cbelsymu 64 9 the the DT cord-006252-cbelsymu 64 10 known know VBN cord-006252-cbelsymu 64 11 seasonal seasonal JJ cord-006252-cbelsymu 64 12 variation variation NN cord-006252-cbelsymu 64 13 in in IN cord-006252-cbelsymu 64 14 mortality mortality NN cord-006252-cbelsymu 64 15 from from IN cord-006252-cbelsymu 64 16 all all DT cord-006252-cbelsymu 64 17 causes cause NNS cord-006252-cbelsymu 64 18 , , , cord-006252-cbelsymu 64 19 as as IN cord-006252-cbelsymu 64 20 shown show VBN cord-006252-cbelsymu 64 21 in in IN cord-006252-cbelsymu 64 22 figure figure NN cord-006252-cbelsymu 64 23 1 1 CD cord-006252-cbelsymu 64 24 . . . cord-006252-cbelsymu 65 1 To to TO cord-006252-cbelsymu 65 2 reduce reduce VB cord-006252-cbelsymu 65 3 the the DT cord-006252-cbelsymu 65 4 chance chance NN cord-006252-cbelsymu 65 5 of of IN cord-006252-cbelsymu 65 6 error error NN cord-006252-cbelsymu 65 7 a a DT cord-006252-cbelsymu 65 8 dashed dash VBN cord-006252-cbelsymu 65 9 line line NN cord-006252-cbelsymu 65 10 equal equal JJ cord-006252-cbelsymu 65 11 to to IN cord-006252-cbelsymu 65 12 1.645 1.645 CD cord-006252-cbelsymu 65 13 standard standard JJ cord-006252-cbelsymu 65 14 deviations deviation NNS cord-006252-cbelsymu 65 15 ( ( -LRB- cord-006252-cbelsymu 65 16 the the DT cord-006252-cbelsymu 65 17 ' ' `` cord-006252-cbelsymu 65 18 epidemic epidemic NN cord-006252-cbelsymu 65 19 threshold threshold NN cord-006252-cbelsymu 65 20 ' ' '' cord-006252-cbelsymu 65 21 ) ) -RRB- cord-006252-cbelsymu 65 22 is be VBZ cord-006252-cbelsymu 65 23 drawn draw VBN cord-006252-cbelsymu 65 24 above above IN cord-006252-cbelsymu 65 25 the the DT cord-006252-cbelsymu 65 26 known know VBN cord-006252-cbelsymu 65 27 season season NN cord-006252-cbelsymu 65 28 incidence incidence NN cord-006252-cbelsymu 65 29 line line NN cord-006252-cbelsymu 65 30 . . . cord-006252-cbelsymu 66 1 When when WRB cord-006252-cbelsymu 66 2 the the DT cord-006252-cbelsymu 66 3 mortality mortality NN cord-006252-cbelsymu 66 4 rate rate NN cord-006252-cbelsymu 66 5 exceeds exceed VBZ cord-006252-cbelsymu 66 6 the the DT cord-006252-cbelsymu 66 7 standard standard JJ cord-006252-cbelsymu 66 8 deviation deviation NN cord-006252-cbelsymu 66 9 , , , cord-006252-cbelsymu 66 10 it -PRON- PRP cord-006252-cbelsymu 66 11 is be VBZ cord-006252-cbelsymu 66 12 considered consider VBN cord-006252-cbelsymu 66 13 significant significant JJ cord-006252-cbelsymu 66 14 . . . cord-006252-cbelsymu 67 1 This this DT cord-006252-cbelsymu 67 2 so so RB cord-006252-cbelsymu 67 3 - - HYPH cord-006252-cbelsymu 67 4 called call VBN cord-006252-cbelsymu 67 5 excess excess JJ cord-006252-cbelsymu 67 6 mortality mortality NN cord-006252-cbelsymu 67 7 is be VBZ cord-006252-cbelsymu 67 8 invariably invariably RB cord-006252-cbelsymu 67 9 associated associate VBN cord-006252-cbelsymu 67 10 with with IN cord-006252-cbelsymu 67 11 an an DT cord-006252-cbelsymu 67 12 outbreak outbreak NN cord-006252-cbelsymu 67 13 of of IN cord-006252-cbelsymu 67 14 influenza influenza NN cord-006252-cbelsymu 67 15 . . . cord-006252-cbelsymu 68 1 Excess excess JJ cord-006252-cbelsymu 68 2 deaths death NNS cord-006252-cbelsymu 68 3 , , , cord-006252-cbelsymu 68 4 therefore therefore RB cord-006252-cbelsymu 68 5 , , , cord-006252-cbelsymu 68 6 are be VBP cord-006252-cbelsymu 68 7 considered consider VBN cord-006252-cbelsymu 68 8 to to TO cord-006252-cbelsymu 68 9 be be VB cord-006252-cbelsymu 68 10 due due JJ cord-006252-cbelsymu 68 11 to to IN cord-006252-cbelsymu 68 12 epidemics epidemic NNS cord-006252-cbelsymu 68 13 of of IN cord-006252-cbelsymu 68 14 influenza influenza NN cord-006252-cbelsymu 68 15 virus virus NN cord-006252-cbelsymu 68 16 . . . cord-006252-cbelsymu 69 1 Quantifying quantify VBG cord-006252-cbelsymu 69 2 morbidity morbidity NN cord-006252-cbelsymu 69 3 from from IN cord-006252-cbelsymu 69 4 influenza influenza NN cord-006252-cbelsymu 69 5 is be VBZ cord-006252-cbelsymu 69 6 more more RBR cord-006252-cbelsymu 69 7 difficult difficult JJ cord-006252-cbelsymu 69 8 . . . cord-006252-cbelsymu 70 1 While while IN cord-006252-cbelsymu 70 2 excess excess JJ cord-006252-cbelsymu 70 3 mortality mortality NN cord-006252-cbelsymu 70 4 occurs occur VBZ cord-006252-cbelsymu 70 5 in in IN cord-006252-cbelsymu 70 6 the the DT cord-006252-cbelsymu 70 7 elderly elderly JJ cord-006252-cbelsymu 70 8 and and CC cord-006252-cbelsymu 70 9 those those DT cord-006252-cbelsymu 70 10 with with IN cord-006252-cbelsymu 70 11 certain certain JJ cord-006252-cbelsymu 70 12 chronic chronic JJ cord-006252-cbelsymu 70 13 diseases disease NNS cord-006252-cbelsymu 70 14 , , , cord-006252-cbelsymu 70 15 morbidity morbidity NN cord-006252-cbelsymu 70 16 is be VBZ cord-006252-cbelsymu 70 17 generally generally RB cord-006252-cbelsymu 70 18 more more RBR cord-006252-cbelsymu 70 19 common common JJ cord-006252-cbelsymu 70 20 among among IN cord-006252-cbelsymu 70 21 healthy healthy JJ cord-006252-cbelsymu 70 22 children child NNS cord-006252-cbelsymu 70 23 and and CC cord-006252-cbelsymu 70 24 young young JJ cord-006252-cbelsymu 70 25 adults adult NNS cord-006252-cbelsymu 70 26 . . . cord-006252-cbelsymu 71 1 The the DT cord-006252-cbelsymu 71 2 severe severe JJ cord-006252-cbelsymu 71 3 morbidity morbidity NN cord-006252-cbelsymu 71 4 associated associate VBN cord-006252-cbelsymu 71 5 with with IN cord-006252-cbelsymu 71 6 influenza influenza NN cord-006252-cbelsymu 71 7 , , , cord-006252-cbelsymu 71 8 such such JJ cord-006252-cbelsymu 71 9 as as IN cord-006252-cbelsymu 71 10 hospitalisation hospitalisation NN cord-006252-cbelsymu 71 11 , , , cord-006252-cbelsymu 71 12 is be VBZ cord-006252-cbelsymu 71 13 most most RBS cord-006252-cbelsymu 71 14 common common JJ cord-006252-cbelsymu 71 15 among among IN cord-006252-cbelsymu 71 16 the the DT cord-006252-cbelsymu 71 17 elderly elderly JJ cord-006252-cbelsymu 71 18 and and CC cord-006252-cbelsymu 71 19 chronically chronically RB cord-006252-cbelsymu 71 20 ill ill JJ cord-006252-cbelsymu 71 21 . . . cord-006252-cbelsymu 72 1 A a DT cord-006252-cbelsymu 72 2 number number NN cord-006252-cbelsymu 72 3 of of IN cord-006252-cbelsymu 72 4 studies study NNS cord-006252-cbelsymu 72 5 have have VBP cord-006252-cbelsymu 72 6 documented document VBN cord-006252-cbelsymu 72 7 the the DT cord-006252-cbelsymu 72 8 toll toll NN cord-006252-cbelsymu 72 9 influenza influenza NN cord-006252-cbelsymu 72 10 exacts exact VBZ cord-006252-cbelsymu 72 11 among among IN cord-006252-cbelsymu 72 12 the the DT cord-006252-cbelsymu 72 13 infirm infirm JJ cord-006252-cbelsymu 72 14 and and CC cord-006252-cbelsymu 72 15 the the DT cord-006252-cbelsymu 72 16 elderly elderly JJ cord-006252-cbelsymu 72 17 . . . cord-006252-cbelsymu 73 1 The the DT cord-006252-cbelsymu 73 2 most most RBS cord-006252-cbelsymu 73 3 recent recent JJ cord-006252-cbelsymu 73 4 large large JJ cord-006252-cbelsymu 73 5 scale scale NN cord-006252-cbelsymu 73 6 study study NN cord-006252-cbelsymu 73 7 on on IN cord-006252-cbelsymu 73 8 influenza influenza NN cord-006252-cbelsymu 73 9 - - HYPH cord-006252-cbelsymu 73 10 related relate VBN cord-006252-cbelsymu 73 11 mortality mortality NN cord-006252-cbelsymu 73 12 is be VBZ cord-006252-cbelsymu 73 13 by by IN cord-006252-cbelsymu 73 14 Barker Barker NNP cord-006252-cbelsymu 73 15 and and CC cord-006252-cbelsymu 73 16 Mullooly Mullooly NNP cord-006252-cbelsymu 73 17 ( ( -LRB- cord-006252-cbelsymu 73 18 1980 1980 CD cord-006252-cbelsymu 73 19 ) ) -RRB- cord-006252-cbelsymu 73 20 . . . cord-006252-cbelsymu 74 1 In in IN cord-006252-cbelsymu 74 2 2 2 CD cord-006252-cbelsymu 74 3 influenza influenza NN cord-006252-cbelsymu 74 4 A a NN cord-006252-cbelsymu 74 5 ( ( -LRB- cord-006252-cbelsymu 74 6 H3N2 H3N2 NNP cord-006252-cbelsymu 74 7 ) ) -RRB- cord-006252-cbelsymu 74 8 epidemics epidemic NNS cord-006252-cbelsymu 74 9 , , , cord-006252-cbelsymu 74 10 they -PRON- PRP cord-006252-cbelsymu 74 11 report report VBP cord-006252-cbelsymu 74 12 that that IN cord-006252-cbelsymu 74 13 11 11 CD cord-006252-cbelsymu 74 14 to to TO cord-006252-cbelsymu 74 15 13 13 CD cord-006252-cbelsymu 74 16 excess excess JJ cord-006252-cbelsymu 74 17 deaths death NNS cord-006252-cbelsymu 74 18 occurred occur VBD cord-006252-cbelsymu 74 19 per per IN cord-006252-cbelsymu 74 20 100 100 CD cord-006252-cbelsymu 74 21 000 000 CD cord-006252-cbelsymu 74 22 persons person NNS cord-006252-cbelsymu 74 23 . . . cord-006252-cbelsymu 75 1 When when WRB cord-006252-cbelsymu 75 2 they -PRON- PRP cord-006252-cbelsymu 75 3 examined examine VBD cord-006252-cbelsymu 75 4 those those DT cord-006252-cbelsymu 75 5 aged aged JJ cord-006252-cbelsymu 75 6 432 432 CD cord-006252-cbelsymu 75 7 $ $ $ cord-006252-cbelsymu 75 8 US US NNP cord-006252-cbelsymu 75 9 1 1 CD cord-006252-cbelsymu 75 10 billion billion CD cord-006252-cbelsymu 75 11 each each DT cord-006252-cbelsymu 75 12 year year NN cord-006252-cbelsymu 75 13 ( ( -LRB- cord-006252-cbelsymu 75 14 Schoenbaum Schoenbaum NNP cord-006252-cbelsymu 75 15 1987 1987 CD cord-006252-cbelsymu 75 16 ) ) -RRB- cord-006252-cbelsymu 75 17 . . . cord-006252-cbelsymu 76 1 In in IN cord-006252-cbelsymu 76 2 reality reality NN cord-006252-cbelsymu 76 3 , , , cord-006252-cbelsymu 76 4 the the DT cord-006252-cbelsymu 76 5 cost cost NN cord-006252-cbelsymu 76 6 is be VBZ cord-006252-cbelsymu 76 7 probably probably RB cord-006252-cbelsymu 76 8 3 3 CD cord-006252-cbelsymu 76 9 to to TO cord-006252-cbelsymu 76 10 5 5 CD cord-006252-cbelsymu 76 11 times time NNS cord-006252-cbelsymu 76 12 greater great JJR cord-006252-cbelsymu 76 13 . . . cord-006252-cbelsymu 77 1 While while IN cord-006252-cbelsymu 77 2 much much JJ cord-006252-cbelsymu 77 3 has have VBZ cord-006252-cbelsymu 77 4 been be VBN cord-006252-cbelsymu 77 5 written write VBN cord-006252-cbelsymu 77 6 on on IN cord-006252-cbelsymu 77 7 the the DT cord-006252-cbelsymu 77 8 cost cost NN cord-006252-cbelsymu 77 9 - - HYPH cord-006252-cbelsymu 77 10 benefit benefit NN cord-006252-cbelsymu 77 11 ratio ratio NN cord-006252-cbelsymu 77 12 for for IN cord-006252-cbelsymu 77 13 influenza influenza NN cord-006252-cbelsymu 77 14 vaccine vaccine NN cord-006252-cbelsymu 77 15 , , , cord-006252-cbelsymu 77 16 in in IN cord-006252-cbelsymu 77 17 persons person NNS cord-006252-cbelsymu 77 18 65 65 CD cord-006252-cbelsymu 77 19 years year NNS cord-006252-cbelsymu 77 20 of of IN cord-006252-cbelsymu 77 21 age age NN cord-006252-cbelsymu 77 22 and and CC cord-006252-cbelsymu 77 23 above above IN cord-006252-cbelsymu 77 24 the the DT cord-006252-cbelsymu 77 25 benefit benefit NN cord-006252-cbelsymu 77 26 clearly clearly RB cord-006252-cbelsymu 77 27 outweighs outweigh VBZ cord-006252-cbelsymu 77 28 the the DT cord-006252-cbelsymu 77 29 cost cost NN cord-006252-cbelsymu 77 30 . . . cord-006252-cbelsymu 78 1 Despite despite IN cord-006252-cbelsymu 78 2 the the DT cord-006252-cbelsymu 78 3 favourable favourable JJ cord-006252-cbelsymu 78 4 impression impression NN cord-006252-cbelsymu 78 5 gained gain VBN cord-006252-cbelsymu 78 6 from from IN cord-006252-cbelsymu 78 7 economic economic JJ cord-006252-cbelsymu 78 8 models model NNS cord-006252-cbelsymu 78 9 , , , cord-006252-cbelsymu 78 10 however however RB cord-006252-cbelsymu 78 11 , , , cord-006252-cbelsymu 78 12 individual individual JJ cord-006252-cbelsymu 78 13 patients patient NNS cord-006252-cbelsymu 78 14 and and CC cord-006252-cbelsymu 78 15 their -PRON- PRP$ cord-006252-cbelsymu 78 16 physicians physician NNS cord-006252-cbelsymu 78 17 do do VBP cord-006252-cbelsymu 78 18 not not RB cord-006252-cbelsymu 78 19 as as IN cord-006252-cbelsymu 78 20 a a DT cord-006252-cbelsymu 78 21 rule rule NN cord-006252-cbelsymu 78 22 perceive perceive VBP cord-006252-cbelsymu 78 23 the the DT cord-006252-cbelsymu 78 24 benefit benefit NN cord-006252-cbelsymu 78 25 . . . cord-006252-cbelsymu 79 1 As as IN cord-006252-cbelsymu 79 2 a a DT cord-006252-cbelsymu 79 3 result result NN cord-006252-cbelsymu 79 4 , , , cord-006252-cbelsymu 79 5 only only RB cord-006252-cbelsymu 79 6 a a DT cord-006252-cbelsymu 79 7 small small JJ cord-006252-cbelsymu 79 8 percentage percentage NN cord-006252-cbelsymu 79 9 of of IN cord-006252-cbelsymu 79 10 the the DT cord-006252-cbelsymu 79 11 elderly elderly JJ cord-006252-cbelsymu 79 12 population population NN cord-006252-cbelsymu 79 13 are be VBP cord-006252-cbelsymu 79 14 vaccinated vaccinate VBN cord-006252-cbelsymu 79 15 each each DT cord-006252-cbelsymu 79 16 year year NN cord-006252-cbelsymu 79 17 . . . cord-006252-cbelsymu 80 1 What what WP cord-006252-cbelsymu 80 2 is be VBZ cord-006252-cbelsymu 80 3 influenza influenza JJ cord-006252-cbelsymu 80 4 ? ? . cord-006252-cbelsymu 81 1 Is be VBZ cord-006252-cbelsymu 81 2 it -PRON- PRP cord-006252-cbelsymu 81 3 easy easy JJ cord-006252-cbelsymu 81 4 to to TO cord-006252-cbelsymu 81 5 diagnose diagnose VB cord-006252-cbelsymu 81 6 ? ? . cord-006252-cbelsymu 82 1 How how WRB cord-006252-cbelsymu 82 2 effective effective JJ cord-006252-cbelsymu 82 3 is be VBZ cord-006252-cbelsymu 82 4 influenza influenza JJ cord-006252-cbelsymu 82 5 vaccine vaccine NN cord-006252-cbelsymu 82 6 ? ? . cord-006252-cbelsymu 83 1 Are be VBP cord-006252-cbelsymu 83 2 the the DT cord-006252-cbelsymu 83 3 side side NN cord-006252-cbelsymu 83 4 effects effect VBZ cord-006252-cbelsymu 83 5 a a DT cord-006252-cbelsymu 83 6 frequent frequent JJ cord-006252-cbelsymu 83 7 concern concern NN cord-006252-cbelsymu 83 8 ? ? . cord-006252-cbelsymu 84 1 What what WDT cord-006252-cbelsymu 84 2 efforts effort NNS cord-006252-cbelsymu 84 3 have have VBP cord-006252-cbelsymu 84 4 been be VBN cord-006252-cbelsymu 84 5 and and CC cord-006252-cbelsymu 84 6 can can MD cord-006252-cbelsymu 84 7 be be VB cord-006252-cbelsymu 84 8 made make VBN cord-006252-cbelsymu 84 9 to to TO cord-006252-cbelsymu 84 10 improve improve VB cord-006252-cbelsymu 84 11 vaccine vaccine NN cord-006252-cbelsymu 84 12 acceptance acceptance NN cord-006252-cbelsymu 84 13 ? ? . cord-006252-cbelsymu 85 1 These these DT cord-006252-cbelsymu 85 2 are be VBP cord-006252-cbelsymu 85 3 some some DT cord-006252-cbelsymu 85 4 of of IN cord-006252-cbelsymu 85 5 the the DT cord-006252-cbelsymu 85 6 important important JJ cord-006252-cbelsymu 85 7 questions question NNS cord-006252-cbelsymu 85 8 we -PRON- PRP cord-006252-cbelsymu 85 9 attempt attempt VBP cord-006252-cbelsymu 85 10 to to TO cord-006252-cbelsymu 85 11 answer answer VB cord-006252-cbelsymu 85 12 in in IN cord-006252-cbelsymu 85 13 this this DT cord-006252-cbelsymu 85 14 article article NN cord-006252-cbelsymu 85 15 . . . cord-006252-cbelsymu 85 16 ! ! . cord-006252-cbelsymu 86 1 Influenza influenza NN cord-006252-cbelsymu 86 2 virus virus NN cord-006252-cbelsymu 86 3 was be VBD cord-006252-cbelsymu 86 4 first first RB cord-006252-cbelsymu 86 5 isolated isolate VBN cord-006252-cbelsymu 86 6 from from IN cord-006252-cbelsymu 86 7 humans human NNS cord-006252-cbelsymu 86 8 in in IN cord-006252-cbelsymu 86 9 the the DT cord-006252-cbelsymu 86 10 1930s 1930 NNS cord-006252-cbelsymu 86 11 ( ( -LRB- cord-006252-cbelsymu 86 12 Ruben Ruben NNP cord-006252-cbelsymu 86 13 1987 1987 CD cord-006252-cbelsymu 86 14 ) ) -RRB- cord-006252-cbelsymu 86 15 . . . cord-006252-cbelsymu 87 1 The the DT cord-006252-cbelsymu 87 2 clinical clinical JJ cord-006252-cbelsymu 87 3 syndrome syndrome NN cord-006252-cbelsymu 87 4 of of IN cord-006252-cbelsymu 87 5 a a DT cord-006252-cbelsymu 87 6 typical typical JJ cord-006252-cbelsymu 87 7 case case NN cord-006252-cbelsymu 87 8 of of IN cord-006252-cbelsymu 87 9 influenza influenza NN cord-006252-cbelsymu 87 10 begins begin VBZ cord-006252-cbelsymu 87 11 with with IN cord-006252-cbelsymu 87 12 fever fever NN cord-006252-cbelsymu 87 13 , , , cord-006252-cbelsymu 87 14 cough cough NN cord-006252-cbelsymu 87 15 and and CC cord-006252-cbelsymu 87 16 myalgias myalgia NNS cord-006252-cbelsymu 87 17 that that WDT cord-006252-cbelsymu 87 18 last last VBD cord-006252-cbelsymu 87 19 for for IN cord-006252-cbelsymu 87 20 a a DT cord-006252-cbelsymu 87 21 few few JJ cord-006252-cbelsymu 87 22 days day NNS cord-006252-cbelsymu 87 23 to to IN cord-006252-cbelsymu 87 24 a a DT cord-006252-cbelsymu 87 25 week week NN cord-006252-cbelsymu 87 26 . . . cord-006252-cbelsymu 88 1 The the DT cord-006252-cbelsymu 88 2 clinical clinical JJ cord-006252-cbelsymu 88 3 course course NN cord-006252-cbelsymu 88 4 may may MD cord-006252-cbelsymu 88 5 be be VB cord-006252-cbelsymu 88 6 complicated complicate VBN cord-006252-cbelsymu 88 7 by by IN cord-006252-cbelsymu 88 8 laryngotracheobronchitis laryngotracheobronchitis NNP cord-006252-cbelsymu 88 9 and and CC cord-006252-cbelsymu 88 10 pneumonia pneumonia NN cord-006252-cbelsymu 88 11 . . . cord-006252-cbelsymu 89 1 Secondary secondary JJ cord-006252-cbelsymu 89 2 bacterial bacterial JJ cord-006252-cbelsymu 89 3 pneumonia pneumonia NN cord-006252-cbelsymu 89 4 may may MD cord-006252-cbelsymu 89 5 occur occur VB cord-006252-cbelsymu 89 6 simultaneously simultaneously RB cord-006252-cbelsymu 89 7 or or CC cord-006252-cbelsymu 89 8 a a DT cord-006252-cbelsymu 89 9 few few JJ cord-006252-cbelsymu 89 10 days day NNS cord-006252-cbelsymu 89 11 later later RB cord-006252-cbelsymu 89 12 . . . cord-006252-cbelsymu 90 1 Hospitalisation hospitalisation NN cord-006252-cbelsymu 90 2 is be VBZ cord-006252-cbelsymu 90 3 more more RBR cord-006252-cbelsymu 90 4 likely likely JJ cord-006252-cbelsymu 90 5 to to TO cord-006252-cbelsymu 90 6 occur occur VB cord-006252-cbelsymu 90 7 in in IN cord-006252-cbelsymu 90 8 individuals individual NNS cord-006252-cbelsymu 90 9 who who WP cord-006252-cbelsymu 90 10 are be VBP cord-006252-cbelsymu 90 11 elderly elderly JJ cord-006252-cbelsymu 90 12 or or CC cord-006252-cbelsymu 90 13 have have VBP cord-006252-cbelsymu 90 14 pre pre VBN cord-006252-cbelsymu 90 15 - - JJ cord-006252-cbelsymu 90 16 existing existing JJ cord-006252-cbelsymu 90 17 cardiac cardiac JJ cord-006252-cbelsymu 90 18 or or CC cord-006252-cbelsymu 90 19 pulmonary pulmonary JJ cord-006252-cbelsymu 90 20 disease disease NN cord-006252-cbelsymu 90 21 . . . cord-006252-cbelsymu 91 1 Children child NNS cord-006252-cbelsymu 91 2 aged age VBN cord-006252-cbelsymu 91 3 under under IN cord-006252-cbelsymu 91 4 12 12 CD cord-006252-cbelsymu 91 5 years year NNS cord-006252-cbelsymu 91 6 taking take VBG cord-006252-cbelsymu 91 7 aspirin aspirin NN cord-006252-cbelsymu 91 8 during during IN cord-006252-cbelsymu 91 9 the the DT cord-006252-cbelsymu 91 10 early early JJ cord-006252-cbelsymu 91 11 phases phase NNS cord-006252-cbelsymu 91 12 of of IN cord-006252-cbelsymu 91 13 infection infection NN cord-006252-cbelsymu 91 14 are be VBP cord-006252-cbelsymu 91 15 more more RBR cord-006252-cbelsymu 91 16 likely likely JJ cord-006252-cbelsymu 91 17 to to TO cord-006252-cbelsymu 91 18 get get VB cord-006252-cbelsymu 91 19 Reye Reye NNP cord-006252-cbelsymu 91 20 's 's POS cord-006252-cbelsymu 91 21 syndrome syndrome NN cord-006252-cbelsymu 91 22 . . . cord-006252-cbelsymu 92 1 Late late JJ cord-006252-cbelsymu 92 2 complications complication NNS cord-006252-cbelsymu 92 3 of of IN cord-006252-cbelsymu 92 4 infection infection NN cord-006252-cbelsymu 92 5 such such JJ cord-006252-cbelsymu 92 6 as as IN cord-006252-cbelsymu 92 7 fatigue fatigue NN cord-006252-cbelsymu 92 8 , , , cord-006252-cbelsymu 92 9 chronic chronic JJ cord-006252-cbelsymu 92 10 cough cough NN cord-006252-cbelsymu 92 11 , , , cord-006252-cbelsymu 92 12 and and CC cord-006252-cbelsymu 92 13 small small JJ cord-006252-cbelsymu 92 14 - - HYPH cord-006252-cbelsymu 92 15 airway airway NN cord-006252-cbelsymu 92 16 disease disease NN cord-006252-cbelsymu 92 17 may may MD cord-006252-cbelsymu 92 18 last last VB cord-006252-cbelsymu 92 19 for for IN cord-006252-cbelsymu 92 20 weeks week NNS cord-006252-cbelsymu 92 21 . . . cord-006252-cbelsymu 93 1 Making make VBG cord-006252-cbelsymu 93 2 a a DT cord-006252-cbelsymu 93 3 diagnosis diagnosis NN cord-006252-cbelsymu 93 4 of of IN cord-006252-cbelsymu 93 5 influenza influenza NN cord-006252-cbelsymu 93 6 virus virus NN cord-006252-cbelsymu 93 7 infection infection NN cord-006252-cbelsymu 93 8 is be VBZ cord-006252-cbelsymu 93 9 difficult difficult JJ cord-006252-cbelsymu 93 10 because because IN cord-006252-cbelsymu 93 11 the the DT cord-006252-cbelsymu 93 12 acute acute JJ cord-006252-cbelsymu 93 13 respiratory respiratory JJ cord-006252-cbelsymu 93 14 syndromes syndrome NNS cord-006252-cbelsymu 93 15 may may MD cord-006252-cbelsymu 93 16 be be VB cord-006252-cbelsymu 93 17 confused confuse VBN cord-006252-cbelsymu 93 18 with with IN cord-006252-cbelsymu 93 19 other other JJ cord-006252-cbelsymu 93 20 viral viral JJ cord-006252-cbelsymu 93 21 respiratory respiratory JJ cord-006252-cbelsymu 93 22 agents agent NNS cord-006252-cbelsymu 93 23 such such JJ cord-006252-cbelsymu 93 24 as as IN cord-006252-cbelsymu 93 25 parainfluenza parainfluenza NNP cord-006252-cbelsymu 93 26 viruses virus NNS cord-006252-cbelsymu 93 27 , , , cord-006252-cbelsymu 93 28 adenoviruses adenovirus NNS cord-006252-cbelsymu 93 29 , , , cord-006252-cbelsymu 93 30 respiratory respiratory JJ cord-006252-cbelsymu 93 31 syncytial syncytial JJ cord-006252-cbelsymu 93 32 viruses virus NNS cord-006252-cbelsymu 93 33 as as RB cord-006252-cbelsymu 93 34 well well RB cord-006252-cbelsymu 93 35 as as IN cord-006252-cbelsymu 93 36 the the DT cord-006252-cbelsymu 93 37 more more RBR cord-006252-cbelsymu 93 38 common common JJ cord-006252-cbelsymu 93 39 rhino rhino NN cord-006252-cbelsymu 93 40 viruses virus NNS cord-006252-cbelsymu 93 41 and and CC cord-006252-cbelsymu 93 42 coronaviruses coronaviruse NNS cord-006252-cbelsymu 93 43 . . . cord-006252-cbelsymu 94 1 Laboratory laboratory NN cord-006252-cbelsymu 94 2 Drugs drug NNS cord-006252-cbelsymu 94 3 & & CC cord-006252-cbelsymu 94 4 Aging age VBG cord-006252-cbelsymu 94 5 1 1 CD cord-006252-cbelsymu 94 6 ( ( -LRB- cord-006252-cbelsymu 94 7 6 6 CD cord-006252-cbelsymu 94 8 ) ) -RRB- cord-006252-cbelsymu 94 9 1991 1991 CD cord-006252-cbelsymu 94 10 tests test NNS cord-006252-cbelsymu 94 11 can can MD cord-006252-cbelsymu 94 12 distinguish distinguish VB cord-006252-cbelsymu 94 13 among among IN cord-006252-cbelsymu 94 14 these these DT cord-006252-cbelsymu 94 15 agents agent NNS cord-006252-cbelsymu 94 16 , , , cord-006252-cbelsymu 94 17 and and CC cord-006252-cbelsymu 94 18 rapid rapid JJ cord-006252-cbelsymu 94 19 , , , cord-006252-cbelsymu 94 20 sensitive sensitive JJ cord-006252-cbelsymu 94 21 tests test NNS cord-006252-cbelsymu 94 22 are be VBP cord-006252-cbelsymu 94 23 now now RB cord-006252-cbelsymu 94 24 available available JJ cord-006252-cbelsymu 94 25 to to TO cord-006252-cbelsymu 94 26 diagnose diagnose VB cord-006252-cbelsymu 94 27 influenza influenza NN cord-006252-cbelsymu 94 28 virus virus NN cord-006252-cbelsymu 94 29 ( ( -LRB- cord-006252-cbelsymu 94 30 Reichelderfer Reichelderfer NNP cord-006252-cbelsymu 94 31 et et FW cord-006252-cbelsymu 94 32 al al NNP cord-006252-cbelsymu 94 33 . . NNP cord-006252-cbelsymu 94 34 1987 1987 CD cord-006252-cbelsymu 94 35 ) ) -RRB- cord-006252-cbelsymu 94 36 . . . cord-006252-cbelsymu 95 1 A a DT cord-006252-cbelsymu 95 2 specific specific JJ cord-006252-cbelsymu 95 3 diagnosis diagnosis NN cord-006252-cbelsymu 95 4 of of IN cord-006252-cbelsymu 95 5 influenza influenza NN cord-006252-cbelsymu 95 6 can can MD cord-006252-cbelsymu 95 7 be be VB cord-006252-cbelsymu 95 8 made make VBN cord-006252-cbelsymu 95 9 in in IN cord-006252-cbelsymu 95 10 a a DT cord-006252-cbelsymu 95 11 few few JJ cord-006252-cbelsymu 95 12 hours hour NNS cord-006252-cbelsymu 95 13 to to IN cord-006252-cbelsymu 95 14 a a DT cord-006252-cbelsymu 95 15 few few JJ cord-006252-cbelsymu 95 16 days day NNS cord-006252-cbelsymu 95 17 , , , cord-006252-cbelsymu 95 18 rather rather RB cord-006252-cbelsymu 95 19 than than IN cord-006252-cbelsymu 95 20 in in IN cord-006252-cbelsymu 95 21 a a DT cord-006252-cbelsymu 95 22 week week NN cord-006252-cbelsymu 95 23 or or CC cord-006252-cbelsymu 95 24 more more JJR cord-006252-cbelsymu 95 25 as as IN cord-006252-cbelsymu 95 26 was be VBD cord-006252-cbelsymu 95 27 the the DT cord-006252-cbelsymu 95 28 case case NN cord-006252-cbelsymu 95 29 several several JJ cord-006252-cbelsymu 95 30 years year NNS cord-006252-cbelsymu 95 31 ago ago RB cord-006252-cbelsymu 95 32 . . . cord-006252-cbelsymu 96 1 While while IN cord-006252-cbelsymu 96 2 influenza influenza NN cord-006252-cbelsymu 96 3 virus virus NN cord-006252-cbelsymu 96 4 infection infection NN cord-006252-cbelsymu 96 5 may may MD cord-006252-cbelsymu 96 6 be be VB cord-006252-cbelsymu 96 7 difficult difficult JJ cord-006252-cbelsymu 96 8 to to TO cord-006252-cbelsymu 96 9 distinguish distinguish VB cord-006252-cbelsymu 96 10 from from IN cord-006252-cbelsymu 96 11 other other JJ cord-006252-cbelsymu 96 12 respiratory respiratory JJ cord-006252-cbelsymu 96 13 viruses virus NNS cord-006252-cbelsymu 96 14 on on IN cord-006252-cbelsymu 96 15 clinical clinical JJ cord-006252-cbelsymu 96 16 grounds ground NNS cord-006252-cbelsymu 96 17 , , , cord-006252-cbelsymu 96 18 influenza influenza NN cord-006252-cbelsymu 96 19 virus virus NN cord-006252-cbelsymu 96 20 is be VBZ cord-006252-cbelsymu 96 21 unique unique JJ cord-006252-cbelsymu 96 22 among among IN cord-006252-cbelsymu 96 23 the the DT cord-006252-cbelsymu 96 24 respiratory respiratory JJ cord-006252-cbelsymu 96 25 viruses virus NNS cord-006252-cbelsymu 96 26 for for IN cord-006252-cbelsymu 96 27 the the DT cord-006252-cbelsymu 96 28 high high JJ cord-006252-cbelsymu 96 29 mortality mortality NN cord-006252-cbelsymu 96 30 associated associate VBN cord-006252-cbelsymu 96 31 with with IN cord-006252-cbelsymu 96 32 it -PRON- PRP cord-006252-cbelsymu 96 33 . . . cord-006252-cbelsymu 97 1 Since since IN cord-006252-cbelsymu 97 2 the the DT cord-006252-cbelsymu 97 3 sixteenth sixteenth JJ cord-006252-cbelsymu 97 4 century century NN cord-006252-cbelsymu 97 5 , , , cord-006252-cbelsymu 97 6 people people NNS cord-006252-cbelsymu 97 7 have have VBP cord-006252-cbelsymu 97 8 recognised recognise VBN cord-006252-cbelsymu 97 9 the the DT cord-006252-cbelsymu 97 10 increased increase VBN cord-006252-cbelsymu 97 11 mortality mortality NN cord-006252-cbelsymu 97 12 resulting result VBG cord-006252-cbelsymu 97 13 from from IN cord-006252-cbelsymu 97 14 an an DT cord-006252-cbelsymu 97 15 influenza influenza NN cord-006252-cbelsymu 97 16 epidemic epidemic NN cord-006252-cbelsymu 97 17 ( ( -LRB- cord-006252-cbelsymu 97 18 Monto Monto NNP cord-006252-cbelsymu 97 19 1987 1987 CD cord-006252-cbelsymu 97 20 ) ) -RRB- cord-006252-cbelsymu 97 21 . . . cord-006252-cbelsymu 98 1 Excess excess JJ cord-006252-cbelsymu 98 2 mortality mortality NN cord-006252-cbelsymu 98 3 from from IN cord-006252-cbelsymu 98 4 influenza influenza NN cord-006252-cbelsymu 98 5 has have VBZ cord-006252-cbelsymu 98 6 been be VBN cord-006252-cbelsymu 98 7 documented document VBN cord-006252-cbelsymu 98 8 since since IN cord-006252-cbelsymu 98 9 1889 1889 CD cord-006252-cbelsymu 98 10 . . . cord-006252-cbelsymu 99 1 On on IN cord-006252-cbelsymu 99 2 occasion occasion NN cord-006252-cbelsymu 99 3 , , , cord-006252-cbelsymu 99 4 influenza influenza NN cord-006252-cbelsymu 99 5 outbreaks outbreak NNS cord-006252-cbelsymu 99 6 reach reach VBP cord-006252-cbelsymu 99 7 pandemic pandemic NN cord-006252-cbelsymu 99 8 proportions proportion NNS cord-006252-cbelsymu 99 9 , , , cord-006252-cbelsymu 99 10 as as IN cord-006252-cbelsymu 99 11 occurred occur VBN cord-006252-cbelsymu 99 12 in in IN cord-006252-cbelsymu 99 13 1918 1918 CD cord-006252-cbelsymu 99 14 . . . cord-006252-cbelsymu 100 1 Influenza influenza NN cord-006252-cbelsymu 100 2 epidemics epidemic NNS cord-006252-cbelsymu 100 3 occur occur VBP cord-006252-cbelsymu 100 4 almost almost RB cord-006252-cbelsymu 100 5 every every DT cord-006252-cbelsymu 100 6 winter winter NN cord-006252-cbelsymu 100 7 . . . cord-006252-cbelsymu 101 1 Quantifying quantify VBG cord-006252-cbelsymu 101 2 the the DT cord-006252-cbelsymu 101 3 mortality mortality NN cord-006252-cbelsymu 101 4 from from IN cord-006252-cbelsymu 101 5 influenza influenza NN cord-006252-cbelsymu 101 6 begins begin VBZ cord-006252-cbelsymu 101 7 with with IN cord-006252-cbelsymu 101 8 describing describe VBG cord-006252-cbelsymu 101 9 the the DT cord-006252-cbelsymu 101 10 known know VBN cord-006252-cbelsymu 101 11 seasonal seasonal JJ cord-006252-cbelsymu 101 12 variation variation NN cord-006252-cbelsymu 101 13 in in IN cord-006252-cbelsymu 101 14 mortality mortality NN cord-006252-cbelsymu 101 15 from from IN cord-006252-cbelsymu 101 16 all all DT cord-006252-cbelsymu 101 17 causes cause NNS cord-006252-cbelsymu 101 18 , , , cord-006252-cbelsymu 101 19 as as IN cord-006252-cbelsymu 101 20 shown show VBN cord-006252-cbelsymu 101 21 in in IN cord-006252-cbelsymu 101 22 figure figure NN cord-006252-cbelsymu 101 23 1 1 CD cord-006252-cbelsymu 101 24 . . . cord-006252-cbelsymu 102 1 To to TO cord-006252-cbelsymu 102 2 reduce reduce VB cord-006252-cbelsymu 102 3 the the DT cord-006252-cbelsymu 102 4 chance chance NN cord-006252-cbelsymu 102 5 of of IN cord-006252-cbelsymu 102 6 error error NN cord-006252-cbelsymu 102 7 a a DT cord-006252-cbelsymu 102 8 dashed dash VBN cord-006252-cbelsymu 102 9 line line NN cord-006252-cbelsymu 102 10 equal equal JJ cord-006252-cbelsymu 102 11 to to IN cord-006252-cbelsymu 102 12 1.645 1.645 CD cord-006252-cbelsymu 102 13 standard standard JJ cord-006252-cbelsymu 102 14 deviations deviation NNS cord-006252-cbelsymu 102 15 ( ( -LRB- cord-006252-cbelsymu 102 16 the the DT cord-006252-cbelsymu 102 17 ' ' `` cord-006252-cbelsymu 102 18 epidemic epidemic NN cord-006252-cbelsymu 102 19 threshold threshold NN cord-006252-cbelsymu 102 20 ' ' '' cord-006252-cbelsymu 102 21 ) ) -RRB- cord-006252-cbelsymu 102 22 is be VBZ cord-006252-cbelsymu 102 23 drawn draw VBN cord-006252-cbelsymu 102 24 above above IN cord-006252-cbelsymu 102 25 the the DT cord-006252-cbelsymu 102 26 known know VBN cord-006252-cbelsymu 102 27 season season NN cord-006252-cbelsymu 102 28 incidence incidence NN cord-006252-cbelsymu 102 29 line line NN cord-006252-cbelsymu 102 30 . . . cord-006252-cbelsymu 103 1 When when WRB cord-006252-cbelsymu 103 2 the the DT cord-006252-cbelsymu 103 3 mortality mortality NN cord-006252-cbelsymu 103 4 rate rate NN cord-006252-cbelsymu 103 5 exceeds exceed VBZ cord-006252-cbelsymu 103 6 the the DT cord-006252-cbelsymu 103 7 standard standard JJ cord-006252-cbelsymu 103 8 deviation deviation NN cord-006252-cbelsymu 103 9 , , , cord-006252-cbelsymu 103 10 it -PRON- PRP cord-006252-cbelsymu 103 11 is be VBZ cord-006252-cbelsymu 103 12 considered consider VBN cord-006252-cbelsymu 103 13 significant significant JJ cord-006252-cbelsymu 103 14 . . . cord-006252-cbelsymu 104 1 This this DT cord-006252-cbelsymu 104 2 so so RB cord-006252-cbelsymu 104 3 - - HYPH cord-006252-cbelsymu 104 4 called call VBN cord-006252-cbelsymu 104 5 excess excess JJ cord-006252-cbelsymu 104 6 mortality mortality NN cord-006252-cbelsymu 104 7 is be VBZ cord-006252-cbelsymu 104 8 invariably invariably RB cord-006252-cbelsymu 104 9 associated associate VBN cord-006252-cbelsymu 104 10 with with IN cord-006252-cbelsymu 104 11 an an DT cord-006252-cbelsymu 104 12 outbreak outbreak NN cord-006252-cbelsymu 104 13 of of IN cord-006252-cbelsymu 104 14 influenza influenza NN cord-006252-cbelsymu 104 15 . . . cord-006252-cbelsymu 105 1 Excess excess JJ cord-006252-cbelsymu 105 2 deaths death NNS cord-006252-cbelsymu 105 3 , , , cord-006252-cbelsymu 105 4 therefore therefore RB cord-006252-cbelsymu 105 5 , , , cord-006252-cbelsymu 105 6 are be VBP cord-006252-cbelsymu 105 7 considered consider VBN cord-006252-cbelsymu 105 8 to to TO cord-006252-cbelsymu 105 9 be be VB cord-006252-cbelsymu 105 10 due due JJ cord-006252-cbelsymu 105 11 to to IN cord-006252-cbelsymu 105 12 epidemics epidemic NNS cord-006252-cbelsymu 105 13 of of IN cord-006252-cbelsymu 105 14 influenza influenza NN cord-006252-cbelsymu 105 15 virus virus NN cord-006252-cbelsymu 105 16 . . . cord-006252-cbelsymu 106 1 Quantifying quantify VBG cord-006252-cbelsymu 106 2 morbidity morbidity NN cord-006252-cbelsymu 106 3 from from IN cord-006252-cbelsymu 106 4 influenza influenza NN cord-006252-cbelsymu 106 5 is be VBZ cord-006252-cbelsymu 106 6 more more RBR cord-006252-cbelsymu 106 7 difficult difficult JJ cord-006252-cbelsymu 106 8 . . . cord-006252-cbelsymu 107 1 While while IN cord-006252-cbelsymu 107 2 excess excess JJ cord-006252-cbelsymu 107 3 mortality mortality NN cord-006252-cbelsymu 107 4 occurs occur VBZ cord-006252-cbelsymu 107 5 in in IN cord-006252-cbelsymu 107 6 the the DT cord-006252-cbelsymu 107 7 elderly elderly JJ cord-006252-cbelsymu 107 8 and and CC cord-006252-cbelsymu 107 9 those those DT cord-006252-cbelsymu 107 10 with with IN cord-006252-cbelsymu 107 11 certain certain JJ cord-006252-cbelsymu 107 12 chronic chronic JJ cord-006252-cbelsymu 107 13 diseases disease NNS cord-006252-cbelsymu 107 14 , , , cord-006252-cbelsymu 107 15 morbidity morbidity NN cord-006252-cbelsymu 107 16 is be VBZ cord-006252-cbelsymu 107 17 generally generally RB cord-006252-cbelsymu 107 18 more more RBR cord-006252-cbelsymu 107 19 common common JJ cord-006252-cbelsymu 107 20 among among IN cord-006252-cbelsymu 107 21 healthy healthy JJ cord-006252-cbelsymu 107 22 children child NNS cord-006252-cbelsymu 107 23 and and CC cord-006252-cbelsymu 107 24 young young JJ cord-006252-cbelsymu 107 25 adults adult NNS cord-006252-cbelsymu 107 26 . . . cord-006252-cbelsymu 108 1 The the DT cord-006252-cbelsymu 108 2 severe severe JJ cord-006252-cbelsymu 108 3 morbidity morbidity NN cord-006252-cbelsymu 108 4 associated associate VBN cord-006252-cbelsymu 108 5 with with IN cord-006252-cbelsymu 108 6 influenza influenza NN cord-006252-cbelsymu 108 7 , , , cord-006252-cbelsymu 108 8 such such JJ cord-006252-cbelsymu 108 9 as as IN cord-006252-cbelsymu 108 10 hospitalisation hospitalisation NN cord-006252-cbelsymu 108 11 , , , cord-006252-cbelsymu 108 12 is be VBZ cord-006252-cbelsymu 108 13 most most RBS cord-006252-cbelsymu 108 14 common common JJ cord-006252-cbelsymu 108 15 among among IN cord-006252-cbelsymu 108 16 the the DT cord-006252-cbelsymu 108 17 elderly elderly JJ cord-006252-cbelsymu 108 18 and and CC cord-006252-cbelsymu 108 19 chronically chronically RB cord-006252-cbelsymu 108 20 ill ill JJ cord-006252-cbelsymu 108 21 . . . cord-006252-cbelsymu 109 1 A a DT cord-006252-cbelsymu 109 2 number number NN cord-006252-cbelsymu 109 3 of of IN cord-006252-cbelsymu 109 4 studies study NNS cord-006252-cbelsymu 109 5 have have VBP cord-006252-cbelsymu 109 6 documented document VBN cord-006252-cbelsymu 109 7 the the DT cord-006252-cbelsymu 109 8 toll toll NN cord-006252-cbelsymu 109 9 influenza influenza NN cord-006252-cbelsymu 109 10 exacts exact VBZ cord-006252-cbelsymu 109 11 among among IN cord-006252-cbelsymu 109 12 the the DT cord-006252-cbelsymu 109 13 infirm infirm JJ cord-006252-cbelsymu 109 14 and and CC cord-006252-cbelsymu 109 15 the the DT cord-006252-cbelsymu 109 16 elderly elderly JJ cord-006252-cbelsymu 109 17 . . . cord-006252-cbelsymu 110 1 The the DT cord-006252-cbelsymu 110 2 most most RBS cord-006252-cbelsymu 110 3 recent recent JJ cord-006252-cbelsymu 110 4 large large JJ cord-006252-cbelsymu 110 5 scale scale NN cord-006252-cbelsymu 110 6 study study NN cord-006252-cbelsymu 110 7 on on IN cord-006252-cbelsymu 110 8 influenza influenza NN cord-006252-cbelsymu 110 9 - - HYPH cord-006252-cbelsymu 110 10 related relate VBN cord-006252-cbelsymu 110 11 mortality mortality NN cord-006252-cbelsymu 110 12 is be VBZ cord-006252-cbelsymu 110 13 by by IN cord-006252-cbelsymu 110 14 Barker Barker NNP cord-006252-cbelsymu 110 15 and and CC cord-006252-cbelsymu 110 16 Mullooly Mullooly NNP cord-006252-cbelsymu 110 17 ( ( -LRB- cord-006252-cbelsymu 110 18 1980 1980 CD cord-006252-cbelsymu 110 19 ) ) -RRB- cord-006252-cbelsymu 110 20 . . . cord-006252-cbelsymu 111 1 In in IN cord-006252-cbelsymu 111 2 2 2 CD cord-006252-cbelsymu 111 3 influenza influenza NN cord-006252-cbelsymu 111 4 A a NN cord-006252-cbelsymu 111 5 ( ( -LRB- cord-006252-cbelsymu 111 6 H3N2 H3N2 NNP cord-006252-cbelsymu 111 7 ) ) -RRB- cord-006252-cbelsymu 111 8 epidemics epidemic NNS cord-006252-cbelsymu 111 9 , , , cord-006252-cbelsymu 111 10 they -PRON- PRP cord-006252-cbelsymu 111 11 report report VBP cord-006252-cbelsymu 111 12 that that IN cord-006252-cbelsymu 111 13 11 11 CD cord-006252-cbelsymu 111 14 to to TO cord-006252-cbelsymu 111 15 13 13 CD cord-006252-cbelsymu 111 16 excess excess JJ cord-006252-cbelsymu 111 17 deaths death NNS cord-006252-cbelsymu 111 18 occurred occur VBD cord-006252-cbelsymu 111 19 per per IN cord-006252-cbelsymu 111 20 100 100 CD cord-006252-cbelsymu 111 21 000 000 CD cord-006252-cbelsymu 111 22 persons person NNS cord-006252-cbelsymu 111 23 . . . cord-006252-cbelsymu 112 1 When when WRB cord-006252-cbelsymu 112 2 they -PRON- PRP cord-006252-cbelsymu 112 3 examined examine VBD cord-006252-cbelsymu 112 4 those those DT cord-006252-cbelsymu 112 5 aged age VBN cord-006252-cbelsymu 112 6 65 65 CD cord-006252-cbelsymu 112 7 years year NNS cord-006252-cbelsymu 112 8 and and CC cord-006252-cbelsymu 112 9 older old JJR cord-006252-cbelsymu 112 10 , , , cord-006252-cbelsymu 112 11 the the DT cord-006252-cbelsymu 112 12 incidence incidence NN cord-006252-cbelsymu 112 13 of of IN cord-006252-cbelsymu 112 14 excess excess JJ cord-006252-cbelsymu 112 15 deaths death NNS cord-006252-cbelsymu 112 16 increased increase VBD cord-006252-cbelsymu 112 17 to to IN cord-006252-cbelsymu 112 18 between between IN cord-006252-cbelsymu 112 19 68 68 CD cord-006252-cbelsymu 112 20 and and CC cord-006252-cbelsymu 112 21 104 104 CD cord-006252-cbelsymu 112 22 per per IN cord-006252-cbelsymu 112 23 100 100 CD cord-006252-cbelsymu 112 24 000 000 CD cord-006252-cbelsymu 112 25 . . . cord-006252-cbelsymu 113 1 These these DT cord-006252-cbelsymu 113 2 estimates estimate NNS cord-006252-cbelsymu 113 3 should should MD cord-006252-cbelsymu 113 4 in in IN cord-006252-cbelsymu 113 5 reality reality NN cord-006252-cbelsymu 113 6 be be VB cord-006252-cbelsymu 113 7 even even RB cord-006252-cbelsymu 113 8 higher high JJR cord-006252-cbelsymu 113 9 because because IN cord-006252-cbelsymu 113 10 pneumonia pneumonia NN cord-006252-cbelsymu 113 11 or or CC cord-006252-cbelsymu 113 12 influenza influenza NN cord-006252-cbelsymu 113 13 is be VBZ cord-006252-cbelsymu 113 14 often often RB cord-006252-cbelsymu 113 15 omitted omit VBN cord-006252-cbelsymu 113 16 from from IN cord-006252-cbelsymu 113 17 the the DT cord-006252-cbelsymu 113 18 diagnoses diagnosis NNS cord-006252-cbelsymu 113 19 listed list VBN cord-006252-cbelsymu 113 20 on on IN cord-006252-cbelsymu 113 21 death death NN cord-006252-cbelsymu 113 22 certificates certificate NNS cord-006252-cbelsymu 113 23 . . . cord-006252-cbelsymu 114 1 showed show VBD cord-006252-cbelsymu 114 2 that that IN cord-006252-cbelsymu 114 3 the the DT cord-006252-cbelsymu 114 4 risk risk NN cord-006252-cbelsymu 114 5 ofhospitalisation ofhospitalisation NN cord-006252-cbelsymu 114 6 for for IN cord-006252-cbelsymu 114 7 acute acute JJ cord-006252-cbelsymu 114 8 respiratory respiratory JJ cord-006252-cbelsymu 114 9 disease disease NN cord-006252-cbelsymu 114 10 ( ( -LRB- cord-006252-cbelsymu 114 11 ARD ARD NNP cord-006252-cbelsymu 114 12 ) ) -RRB- cord-006252-cbelsymu 114 13 during during IN cord-006252-cbelsymu 114 14 influenza influenza NN cord-006252-cbelsymu 114 15 epidemics epidemic NNS cord-006252-cbelsymu 114 16 was be VBD cord-006252-cbelsymu 114 17 19.7 19.7 CD cord-006252-cbelsymu 114 18 per per IN cord-006252-cbelsymu 114 19 10 10 CD cord-006252-cbelsymu 114 20 000 000 CD cord-006252-cbelsymu 114 21 persons person NNS cord-006252-cbelsymu 114 22 with with IN cord-006252-cbelsymu 114 23 high high JJ cord-006252-cbelsymu 114 24 risk risk NN cord-006252-cbelsymu 114 25 conditions condition NNS cord-006252-cbelsymu 114 26 for for IN cord-006252-cbelsymu 114 27 which which WDT cord-006252-cbelsymu 114 28 influenza influenza NN cord-006252-cbelsymu 114 29 vaccine vaccine NN cord-006252-cbelsymu 114 30 is be VBZ cord-006252-cbelsymu 114 31 indicated indicate VBN cord-006252-cbelsymu 114 32 , , , cord-006252-cbelsymu 114 33 compared compare VBN cord-006252-cbelsymu 114 34 to to IN cord-006252-cbelsymu 114 35 9.3 9.3 CD cord-006252-cbelsymu 114 36 per per IN cord-006252-cbelsymu 114 37 10 10 CD cord-006252-cbelsymu 114 38 000 000 CD cord-006252-cbelsymu 114 39 for for IN cord-006252-cbelsymu 114 40 persons person NNS cord-006252-cbelsymu 114 41 without without IN cord-006252-cbelsymu 114 42 these these DT cord-006252-cbelsymu 114 43 conditions condition NNS cord-006252-cbelsymu 114 44 . . . cord-006252-cbelsymu 115 1 Chronic chronic JJ cord-006252-cbelsymu 115 2 pulmonary pulmonary JJ cord-006252-cbelsymu 115 3 disorders disorder NNS cord-006252-cbelsymu 115 4 followed follow VBN cord-006252-cbelsymu 115 5 by by IN cord-006252-cbelsymu 115 6 chronic chronic JJ cord-006252-cbelsymu 115 7 cardiac cardiac JJ cord-006252-cbelsymu 115 8 conditions condition NNS cord-006252-cbelsymu 115 9 were be VBD cord-006252-cbelsymu 115 10 the the DT cord-006252-cbelsymu 115 11 most most RBS cord-006252-cbelsymu 115 12 common common JJ cord-006252-cbelsymu 115 13 highrisk highrisk JJ cord-006252-cbelsymu 115 14 conditions condition NNS cord-006252-cbelsymu 115 15 . . . cord-006252-cbelsymu 116 1 Renal renal JJ cord-006252-cbelsymu 116 2 failure failure NN cord-006252-cbelsymu 116 3 , , , cord-006252-cbelsymu 116 4 diabetes diabetes NN cord-006252-cbelsymu 116 5 and and CC cord-006252-cbelsymu 116 6 long long JJ cord-006252-cbelsymu 116 7 term term NN cord-006252-cbelsymu 116 8 care care NN cord-006252-cbelsymu 116 9 residence residence NN cord-006252-cbelsymu 116 10 are be VBP cord-006252-cbelsymu 116 11 other other JJ cord-006252-cbelsymu 116 12 risk risk NN cord-006252-cbelsymu 116 13 factors factor NNS cord-006252-cbelsymu 116 14 . . . cord-006252-cbelsymu 117 1 For for IN cord-006252-cbelsymu 117 2 persons person NNS cord-006252-cbelsymu 117 3 over over IN cord-006252-cbelsymu 117 4 65 65 CD cord-006252-cbelsymu 117 5 years year NNS cord-006252-cbelsymu 117 6 of of IN cord-006252-cbelsymu 117 7 age age NN cord-006252-cbelsymu 117 8 with with IN cord-006252-cbelsymu 117 9 a a DT cord-006252-cbelsymu 117 10 concomitant concomitant JJ cord-006252-cbelsymu 117 11 chronic chronic JJ cord-006252-cbelsymu 117 12 pulmonary pulmonary JJ cord-006252-cbelsymu 117 13 condition condition NN cord-006252-cbelsymu 117 14 the the DT cord-006252-cbelsymu 117 15 hospitalisation hospitalisation NN cord-006252-cbelsymu 117 16 rate rate NN cord-006252-cbelsymu 117 17 for for IN cord-006252-cbelsymu 117 18 ARD ARD NNP cord-006252-cbelsymu 117 19 soared soar VBD cord-006252-cbelsymu 117 20 to to IN cord-006252-cbelsymu 117 21 87.5 87.5 CD cord-006252-cbelsymu 117 22 per per IN cord-006252-cbelsymu 117 23 10 10 CD cord-006252-cbelsymu 117 24 000 000 CD cord-006252-cbelsymu 117 25 . . . cord-006252-cbelsymu 118 1 The the DT cord-006252-cbelsymu 118 2 peak peak NN cord-006252-cbelsymu 118 3 of of IN cord-006252-cbelsymu 118 4 hospitalisations hospitalisation NNS cord-006252-cbelsymu 118 5 for for IN cord-006252-cbelsymu 118 6 ARD ARD NNP cord-006252-cbelsymu 118 7 typically typically RB cord-006252-cbelsymu 118 8 followed follow VBN cord-006252-cbelsymu 118 9 by by IN cord-006252-cbelsymu 118 10 one one CD cord-006252-cbelsymu 118 11 week week NN cord-006252-cbelsymu 118 12 the the DT cord-006252-cbelsymu 118 13 peak peak NN cord-006252-cbelsymu 118 14 of of IN cord-006252-cbelsymu 118 15 influenza influenza NN cord-006252-cbelsymu 118 16 virus virus NN cord-006252-cbelsymu 118 17 isolations isolation NNS cord-006252-cbelsymu 118 18 ( ( -LRB- cord-006252-cbelsymu 118 19 Perrotta Perrotta NNP cord-006252-cbelsymu 118 20 et et NNP cord-006252-cbelsymu 118 21 al al NNP cord-006252-cbelsymu 118 22 . . . cord-006252-cbelsymu 118 23 1985 1985 CD cord-006252-cbelsymu 118 24 ) ) -RRB- cord-006252-cbelsymu 118 25 . . . cord-006252-cbelsymu 119 1 The the DT cord-006252-cbelsymu 119 2 disease disease NN cord-006252-cbelsymu 119 3 severity severity NN cord-006252-cbelsymu 119 4 varies vary VBZ cord-006252-cbelsymu 119 5 according accord VBG cord-006252-cbelsymu 119 6 to to IN cord-006252-cbelsymu 119 7 the the DT cord-006252-cbelsymu 119 8 influenza influenza NN cord-006252-cbelsymu 119 9 strain strain NN cord-006252-cbelsymu 119 10 and and CC cord-006252-cbelsymu 119 11 the the DT cord-006252-cbelsymu 119 12 age age NN cord-006252-cbelsymu 119 13 ofthe ofthe DT cord-006252-cbelsymu 119 14 patient patient NN cord-006252-cbelsymu 119 15 . . . cord-006252-cbelsymu 120 1 The the DT cord-006252-cbelsymu 120 2 H3N2 H3N2 NNP cord-006252-cbelsymu 120 3 subtype subtype NN cord-006252-cbelsymu 120 4 of of IN cord-006252-cbelsymu 120 5 influenza influenza NN cord-006252-cbelsymu 120 6 A a DT cord-006252-cbelsymu 120 7 causes cause NNS cord-006252-cbelsymu 120 8 the the DT cord-006252-cbelsymu 120 9 most most RBS cord-006252-cbelsymu 120 10 severe severe JJ cord-006252-cbelsymu 120 11 ilness ilness NN cord-006252-cbelsymu 120 12 , , , cord-006252-cbelsymu 120 13 while while IN cord-006252-cbelsymu 120 14 the the DT cord-006252-cbelsymu 120 15 HI HI NNP cord-006252-cbelsymu 120 16 N N NNP cord-006252-cbelsymu 120 17 1 1 CD cord-006252-cbelsymu 120 18 subtype subtype NN cord-006252-cbelsymu 120 19 of of IN cord-006252-cbelsymu 120 20 influenza influenza NN cord-006252-cbelsymu 120 21 A a NN cord-006252-cbelsymu 120 22 is be VBZ cord-006252-cbelsymu 120 23 associated associate VBN cord-006252-cbelsymu 120 24 with with IN cord-006252-cbelsymu 120 25 the the DT cord-006252-cbelsymu 120 26 mildest mild JJS cord-006252-cbelsymu 120 27 illness illness NN cord-006252-cbelsymu 120 28 ( ( -LRB- cord-006252-cbelsymu 120 29 Monto Monto NNP cord-006252-cbelsymu 120 30 et et NNP cord-006252-cbelsymu 120 31 al al NNP cord-006252-cbelsymu 120 32 . . . cord-006252-cbelsymu 120 33 1985 1985 CD cord-006252-cbelsymu 120 34 ) ) -RRB- cord-006252-cbelsymu 120 35 . . . cord-006252-cbelsymu 121 1 Type type NN cord-006252-cbelsymu 121 2 B B NNP cord-006252-cbelsymu 121 3 influenza influenza NN cord-006252-cbelsymu 121 4 causes cause VBZ cord-006252-cbelsymu 121 5 an an DT cord-006252-cbelsymu 121 6 illness illness NN cord-006252-cbelsymu 121 7 intermediate intermediate JJ cord-006252-cbelsymu 121 8 in in IN cord-006252-cbelsymu 121 9 severity severity NN cord-006252-cbelsymu 121 10 between between IN cord-006252-cbelsymu 121 11 the the DT cord-006252-cbelsymu 121 12 2 2 CD cord-006252-cbelsymu 121 13 A A NNP cord-006252-cbelsymu 121 14 subtypes subtype NNS cord-006252-cbelsymu 121 15 . . . cord-006252-cbelsymu 122 1 A a DT cord-006252-cbelsymu 122 2 third third JJ cord-006252-cbelsymu 122 3 type type NN cord-006252-cbelsymu 122 4 of of IN cord-006252-cbelsymu 122 5 influenza influenza NN cord-006252-cbelsymu 122 6 , , , cord-006252-cbelsymu 122 7 type type NN cord-006252-cbelsymu 122 8 C c NN cord-006252-cbelsymu 122 9 , , , cord-006252-cbelsymu 122 10 is be VBZ cord-006252-cbelsymu 122 11 rarely rarely RB cord-006252-cbelsymu 122 12 responsible responsible JJ cord-006252-cbelsymu 122 13 for for IN cord-006252-cbelsymu 122 14 epidemic epidemic NN cord-006252-cbelsymu 122 15 disease disease NN cord-006252-cbelsymu 122 16 . . . cord-006252-cbelsymu 123 1 But but CC cord-006252-cbelsymu 123 2 why why WRB cord-006252-cbelsymu 123 3 is be VBZ cord-006252-cbelsymu 123 4 influenza influenza NN cord-006252-cbelsymu 123 5 a a DT cord-006252-cbelsymu 123 6 problem problem NN cord-006252-cbelsymu 123 7 year year NN cord-006252-cbelsymu 123 8 after after IN cord-006252-cbelsymu 123 9 year year NN cord-006252-cbelsymu 123 10 ? ? . cord-006252-cbelsymu 124 1 Becoming become VBG cord-006252-cbelsymu 124 2 infected infect VBN cord-006252-cbelsymu 124 3 with with IN cord-006252-cbelsymu 124 4 each each DT cord-006252-cbelsymu 124 5 of of IN cord-006252-cbelsymu 124 6 the the DT cord-006252-cbelsymu 124 7 3 3 CD cord-006252-cbelsymu 124 8 strains strain NNS cord-006252-cbelsymu 124 9 of of IN cord-006252-cbelsymu 124 10 influenza influenza NN cord-006252-cbelsymu 124 11 does do VBZ cord-006252-cbelsymu 124 12 not not RB cord-006252-cbelsymu 124 13 confer confer VB cord-006252-cbelsymu 124 14 long long RB cord-006252-cbelsymu 124 15 - - HYPH cord-006252-cbelsymu 124 16 lasting last VBG cord-006252-cbelsymu 124 17 immunity immunity NN cord-006252-cbelsymu 124 18 ; ; : cord-006252-cbelsymu 124 19 in in IN cord-006252-cbelsymu 124 20 contrast contrast NN cord-006252-cbelsymu 124 21 , , , cord-006252-cbelsymu 124 22 becoming become VBG cord-006252-cbelsymu 124 23 infected infect VBN cord-006252-cbelsymu 124 24 naturally naturally RB cord-006252-cbelsymu 124 25 with with IN cord-006252-cbelsymu 124 26 , , , cord-006252-cbelsymu 124 27 for for IN cord-006252-cbelsymu 124 28 example example NN cord-006252-cbelsymu 124 29 , , , cord-006252-cbelsymu 124 30 measles measle NNS cord-006252-cbelsymu 124 31 does do VBZ cord-006252-cbelsymu 124 32 confer confer VB cord-006252-cbelsymu 124 33 long long RB cord-006252-cbelsymu 124 34 - - HYPH cord-006252-cbelsymu 124 35 lasting last VBG cord-006252-cbelsymu 124 36 immunity immunity NN cord-006252-cbelsymu 124 37 . . . cord-006252-cbelsymu 125 1 Why why WRB cord-006252-cbelsymu 125 2 the the DT cord-006252-cbelsymu 125 3 difference difference NN cord-006252-cbelsymu 125 4 ? ? . cord-006252-cbelsymu 126 1 There there EX cord-006252-cbelsymu 126 2 is be VBZ cord-006252-cbelsymu 126 3 only only RB cord-006252-cbelsymu 126 4 I -PRON- PRP cord-006252-cbelsymu 126 5 strain strain VBP cord-006252-cbelsymu 126 6 of of IN cord-006252-cbelsymu 126 7 measles measle NNS cord-006252-cbelsymu 126 8 and and CC cord-006252-cbelsymu 127 1 its -PRON- PRP$ cord-006252-cbelsymu 127 2 nonsegmented nonsegmente VBN cord-006252-cbelsymu 127 3 genome genome NN cord-006252-cbelsymu 127 4 preserves preserve VBZ cord-006252-cbelsymu 127 5 its -PRON- PRP$ cord-006252-cbelsymu 127 6 Prevention Prevention NNP cord-006252-cbelsymu 127 7 and and CC cord-006252-cbelsymu 127 8 Treatment Treatment NNP cord-006252-cbelsymu 127 9 of of IN cord-006252-cbelsymu 127 10 Influenza Influenza NNP cord-006252-cbelsymu 127 11 65 65 CD cord-006252-cbelsymu 127 12 years year NNS cord-006252-cbelsymu 127 13 and and CC cord-006252-cbelsymu 127 14 older old JJR cord-006252-cbelsymu 127 15 , , , cord-006252-cbelsymu 127 16 the the DT cord-006252-cbelsymu 127 17 incidence incidence NN cord-006252-cbelsymu 127 18 of of IN cord-006252-cbelsymu 127 19 excess excess JJ cord-006252-cbelsymu 127 20 deaths death NNS cord-006252-cbelsymu 127 21 increased increase VBD cord-006252-cbelsymu 127 22 to to IN cord-006252-cbelsymu 127 23 between between IN cord-006252-cbelsymu 127 24 68 68 CD cord-006252-cbelsymu 127 25 and and CC cord-006252-cbelsymu 127 26 104 104 CD cord-006252-cbelsymu 127 27 per per IN cord-006252-cbelsymu 127 28 100 100 CD cord-006252-cbelsymu 127 29 000 000 CD cord-006252-cbelsymu 127 30 . . . cord-006252-cbelsymu 128 1 These these DT cord-006252-cbelsymu 128 2 estimates estimate NNS cord-006252-cbelsymu 128 3 should should MD cord-006252-cbelsymu 128 4 in in IN cord-006252-cbelsymu 128 5 reality reality NN cord-006252-cbelsymu 128 6 be be VB cord-006252-cbelsymu 128 7 even even RB cord-006252-cbelsymu 128 8 higher high JJR cord-006252-cbelsymu 128 9 because because IN cord-006252-cbelsymu 128 10 pneumonia pneumonia NN cord-006252-cbelsymu 128 11 or or CC cord-006252-cbelsymu 128 12 influenza influenza NN cord-006252-cbelsymu 128 13 is be VBZ cord-006252-cbelsymu 128 14 often often RB cord-006252-cbelsymu 128 15 omitted omit VBN cord-006252-cbelsymu 128 16 from from IN cord-006252-cbelsymu 128 17 the the DT cord-006252-cbelsymu 128 18 diagnoses diagnosis NNS cord-006252-cbelsymu 128 19 listed list VBN cord-006252-cbelsymu 128 20 on on IN cord-006252-cbelsymu 128 21 death death NN cord-006252-cbelsymu 128 22 certificates certificate NNS cord-006252-cbelsymu 128 23 . . . cord-006252-cbelsymu 129 1 showed show VBD cord-006252-cbelsymu 129 2 that that IN cord-006252-cbelsymu 129 3 the the DT cord-006252-cbelsymu 129 4 risk risk NN cord-006252-cbelsymu 129 5 of of IN cord-006252-cbelsymu 129 6 hospitalisation hospitalisation NN cord-006252-cbelsymu 129 7 for for IN cord-006252-cbelsymu 129 8 acute acute JJ cord-006252-cbelsymu 129 9 respiratory respiratory JJ cord-006252-cbelsymu 129 10 disease disease NN cord-006252-cbelsymu 129 11 ( ( -LRB- cord-006252-cbelsymu 129 12 ARD ARD NNP cord-006252-cbelsymu 129 13 ) ) -RRB- cord-006252-cbelsymu 129 14 during during IN cord-006252-cbelsymu 129 15 influenza influenza NN cord-006252-cbelsymu 129 16 epidemics epidemic NNS cord-006252-cbelsymu 129 17 was be VBD cord-006252-cbelsymu 129 18 19.7 19.7 CD cord-006252-cbelsymu 129 19 per per IN cord-006252-cbelsymu 129 20 10000 10000 CD cord-006252-cbelsymu 129 21 persons person NNS cord-006252-cbelsymu 129 22 with with IN cord-006252-cbelsymu 129 23 high high JJ cord-006252-cbelsymu 129 24 risk risk NN cord-006252-cbelsymu 129 25 conditions condition NNS cord-006252-cbelsymu 129 26 for for IN cord-006252-cbelsymu 129 27 which which WDT cord-006252-cbelsymu 129 28 influenza influenza NN cord-006252-cbelsymu 129 29 vaccine vaccine NN cord-006252-cbelsymu 129 30 is be VBZ cord-006252-cbelsymu 129 31 indicated indicate VBN cord-006252-cbelsymu 129 32 , , , cord-006252-cbelsymu 129 33 compared compare VBN cord-006252-cbelsymu 129 34 to to IN cord-006252-cbelsymu 129 35 9.3 9.3 CD cord-006252-cbelsymu 129 36 per per IN cord-006252-cbelsymu 129 37 10 10 CD cord-006252-cbelsymu 129 38 000 000 CD cord-006252-cbelsymu 129 39 for for IN cord-006252-cbelsymu 129 40 persons person NNS cord-006252-cbelsymu 129 41 without without IN cord-006252-cbelsymu 129 42 these these DT cord-006252-cbelsymu 129 43 conditions condition NNS cord-006252-cbelsymu 129 44 . . . cord-006252-cbelsymu 130 1 Chronic chronic JJ cord-006252-cbelsymu 130 2 pulmonary pulmonary JJ cord-006252-cbelsymu 130 3 disorders disorder NNS cord-006252-cbelsymu 130 4 followed follow VBN cord-006252-cbelsymu 130 5 by by IN cord-006252-cbelsymu 130 6 chronic chronic JJ cord-006252-cbelsymu 130 7 cardiac cardiac JJ cord-006252-cbelsymu 130 8 conditions condition NNS cord-006252-cbelsymu 130 9 were be VBD cord-006252-cbelsymu 130 10 the the DT cord-006252-cbelsymu 130 11 most most RBS cord-006252-cbelsymu 130 12 common common JJ cord-006252-cbelsymu 130 13 highrisk highrisk JJ cord-006252-cbelsymu 130 14 conditions condition NNS cord-006252-cbelsymu 130 15 . . . cord-006252-cbelsymu 131 1 Renal renal JJ cord-006252-cbelsymu 131 2 failure failure NN cord-006252-cbelsymu 131 3 , , , cord-006252-cbelsymu 131 4 diabetes diabetes NN cord-006252-cbelsymu 131 5 and and CC cord-006252-cbelsymu 131 6 long long JJ cord-006252-cbelsymu 131 7 term term NN cord-006252-cbelsymu 131 8 care care NN cord-006252-cbelsymu 131 9 residence residence NN cord-006252-cbelsymu 131 10 are be VBP cord-006252-cbelsymu 131 11 other other JJ cord-006252-cbelsymu 131 12 risk risk NN cord-006252-cbelsymu 131 13 factors factor NNS cord-006252-cbelsymu 131 14 . . . cord-006252-cbelsymu 132 1 For for IN cord-006252-cbelsymu 132 2 persons person NNS cord-006252-cbelsymu 132 3 over over IN cord-006252-cbelsymu 132 4 65 65 CD cord-006252-cbelsymu 132 5 years year NNS cord-006252-cbelsymu 132 6 of of IN cord-006252-cbelsymu 132 7 age age NN cord-006252-cbelsymu 132 8 with with IN cord-006252-cbelsymu 132 9 a a DT cord-006252-cbelsymu 132 10 concomitant concomitant JJ cord-006252-cbelsymu 132 11 chronic chronic JJ cord-006252-cbelsymu 132 12 pulmonary pulmonary JJ cord-006252-cbelsymu 132 13 condition condition NN cord-006252-cbelsymu 132 14 the the DT cord-006252-cbelsymu 132 15 hospitalisation hospitalisation NN cord-006252-cbelsymu 132 16 rate rate NN cord-006252-cbelsymu 132 17 for for IN cord-006252-cbelsymu 132 18 ARD ARD NNP cord-006252-cbelsymu 132 19 soared soar VBD cord-006252-cbelsymu 132 20 to to IN cord-006252-cbelsymu 132 21 87.5 87.5 CD cord-006252-cbelsymu 132 22 per per IN cord-006252-cbelsymu 132 23 10 10 CD cord-006252-cbelsymu 132 24 000 000 CD cord-006252-cbelsymu 132 25 . . . cord-006252-cbelsymu 133 1 The the DT cord-006252-cbelsymu 133 2 peak peak NN cord-006252-cbelsymu 133 3 of of IN cord-006252-cbelsymu 133 4 hospitalisations hospitalisation NNS cord-006252-cbelsymu 133 5 for for IN cord-006252-cbelsymu 133 6 ARD ARD NNP cord-006252-cbelsymu 133 7 typically typically RB cord-006252-cbelsymu 133 8 followed follow VBN cord-006252-cbelsymu 133 9 by by IN cord-006252-cbelsymu 133 10 one one CD cord-006252-cbelsymu 133 11 week week NN cord-006252-cbelsymu 133 12 the the DT cord-006252-cbelsymu 133 13 peak peak NN cord-006252-cbelsymu 133 14 of of IN cord-006252-cbelsymu 133 15 influenza influenza NN cord-006252-cbelsymu 133 16 virus virus NN cord-006252-cbelsymu 133 17 isolations isolation NNS cord-006252-cbelsymu 133 18 ( ( -LRB- cord-006252-cbelsymu 133 19 Perrotta Perrotta NNP cord-006252-cbelsymu 133 20 et et NNP cord-006252-cbelsymu 133 21 al al NNP cord-006252-cbelsymu 133 22 . . . cord-006252-cbelsymu 133 23 1985 1985 CD cord-006252-cbelsymu 133 24 ) ) -RRB- cord-006252-cbelsymu 133 25 . . . cord-006252-cbelsymu 134 1 The the DT cord-006252-cbelsymu 134 2 disease disease NN cord-006252-cbelsymu 134 3 severity severity NN cord-006252-cbelsymu 134 4 varies vary VBZ cord-006252-cbelsymu 134 5 according accord VBG cord-006252-cbelsymu 134 6 to to IN cord-006252-cbelsymu 134 7 the the DT cord-006252-cbelsymu 134 8 influenza influenza NN cord-006252-cbelsymu 134 9 strain strain NN cord-006252-cbelsymu 134 10 and and CC cord-006252-cbelsymu 134 11 the the DT cord-006252-cbelsymu 134 12 age age NN cord-006252-cbelsymu 134 13 of of IN cord-006252-cbelsymu 134 14 the the DT cord-006252-cbelsymu 134 15 patient patient NN cord-006252-cbelsymu 134 16 . . . cord-006252-cbelsymu 135 1 The the DT cord-006252-cbelsymu 135 2 H3N2 H3N2 NNP cord-006252-cbelsymu 135 3 subtype subtype NN cord-006252-cbelsymu 135 4 of of IN cord-006252-cbelsymu 135 5 influenza influenza NN cord-006252-cbelsymu 135 6 A a DT cord-006252-cbelsymu 135 7 causes cause NNS cord-006252-cbelsymu 135 8 the the DT cord-006252-cbelsymu 135 9 most most RBS cord-006252-cbelsymu 135 10 severe severe JJ cord-006252-cbelsymu 135 11 ilness ilness NN cord-006252-cbelsymu 135 12 , , , cord-006252-cbelsymu 135 13 while while IN cord-006252-cbelsymu 135 14 the the DT cord-006252-cbelsymu 135 15 HI HI NNP cord-006252-cbelsymu 135 16 N N NNP cord-006252-cbelsymu 135 17 1 1 CD cord-006252-cbelsymu 135 18 subtype subtype NN cord-006252-cbelsymu 135 19 of of IN cord-006252-cbelsymu 135 20 influenza influenza NN cord-006252-cbelsymu 135 21 A a NN cord-006252-cbelsymu 135 22 is be VBZ cord-006252-cbelsymu 135 23 associated associate VBN cord-006252-cbelsymu 135 24 with with IN cord-006252-cbelsymu 135 25 the the DT cord-006252-cbelsymu 135 26 mildest mild JJS cord-006252-cbelsymu 135 27 illness illness NN cord-006252-cbelsymu 135 28 ( ( -LRB- cord-006252-cbelsymu 135 29 Monto Monto NNP cord-006252-cbelsymu 135 30 et et NNP cord-006252-cbelsymu 135 31 al al NNP cord-006252-cbelsymu 135 32 . . . cord-006252-cbelsymu 135 33 1985 1985 CD cord-006252-cbelsymu 135 34 ) ) -RRB- cord-006252-cbelsymu 135 35 . . . cord-006252-cbelsymu 136 1 Type type NN cord-006252-cbelsymu 136 2 B B NNP cord-006252-cbelsymu 136 3 influenza influenza NN cord-006252-cbelsymu 136 4 causes cause VBZ cord-006252-cbelsymu 136 5 an an DT cord-006252-cbelsymu 136 6 illness illness NN cord-006252-cbelsymu 136 7 intermediate intermediate JJ cord-006252-cbelsymu 136 8 in in IN cord-006252-cbelsymu 136 9 severity severity NN cord-006252-cbelsymu 136 10 between between IN cord-006252-cbelsymu 136 11 the the DT cord-006252-cbelsymu 136 12 2 2 CD cord-006252-cbelsymu 136 13 A A NNP cord-006252-cbelsymu 136 14 subtypes subtype NNS cord-006252-cbelsymu 136 15 . . . cord-006252-cbelsymu 137 1 A a DT cord-006252-cbelsymu 137 2 third third JJ cord-006252-cbelsymu 137 3 type type NN cord-006252-cbelsymu 137 4 of of IN cord-006252-cbelsymu 137 5 influenza influenza NN cord-006252-cbelsymu 137 6 , , , cord-006252-cbelsymu 137 7 type type NN cord-006252-cbelsymu 137 8 C c NN cord-006252-cbelsymu 137 9 , , , cord-006252-cbelsymu 137 10 is be VBZ cord-006252-cbelsymu 137 11 rarely rarely RB cord-006252-cbelsymu 137 12 responsible responsible JJ cord-006252-cbelsymu 137 13 for for IN cord-006252-cbelsymu 137 14 epidemic epidemic NN cord-006252-cbelsymu 137 15 disease disease NN cord-006252-cbelsymu 137 16 . . . cord-006252-cbelsymu 138 1 But but CC cord-006252-cbelsymu 138 2 why why WRB cord-006252-cbelsymu 138 3 is be VBZ cord-006252-cbelsymu 138 4 influenza influenza NN cord-006252-cbelsymu 138 5 a a DT cord-006252-cbelsymu 138 6 problem problem NN cord-006252-cbelsymu 138 7 year year NN cord-006252-cbelsymu 138 8 after after IN cord-006252-cbelsymu 138 9 year year NN cord-006252-cbelsymu 138 10 ? ? . cord-006252-cbelsymu 139 1 Becoming become VBG cord-006252-cbelsymu 139 2 infected infect VBN cord-006252-cbelsymu 139 3 with with IN cord-006252-cbelsymu 139 4 each each DT cord-006252-cbelsymu 139 5 of of IN cord-006252-cbelsymu 139 6 the the DT cord-006252-cbelsymu 139 7 3 3 CD cord-006252-cbelsymu 139 8 strains strain NNS cord-006252-cbelsymu 139 9 of of IN cord-006252-cbelsymu 139 10 influenza influenza NN cord-006252-cbelsymu 139 11 does do VBZ cord-006252-cbelsymu 139 12 not not RB cord-006252-cbelsymu 139 13 confer confer VB cord-006252-cbelsymu 139 14 long long RB cord-006252-cbelsymu 139 15 - - HYPH cord-006252-cbelsymu 139 16 lasting last VBG cord-006252-cbelsymu 139 17 immunity immunity NN cord-006252-cbelsymu 139 18 ; ; : cord-006252-cbelsymu 139 19 in in IN cord-006252-cbelsymu 139 20 contrast contrast NN cord-006252-cbelsymu 139 21 , , , cord-006252-cbelsymu 139 22 becoming become VBG cord-006252-cbelsymu 139 23 infected infect VBN cord-006252-cbelsymu 139 24 naturally naturally RB cord-006252-cbelsymu 139 25 with with IN cord-006252-cbelsymu 139 26 , , , cord-006252-cbelsymu 139 27 for for IN cord-006252-cbelsymu 139 28 example example NN cord-006252-cbelsymu 139 29 , , , cord-006252-cbelsymu 139 30 measles measle NNS cord-006252-cbelsymu 139 31 does do VBZ cord-006252-cbelsymu 139 32 confer confer VB cord-006252-cbelsymu 139 33 long long RB cord-006252-cbelsymu 139 34 - - HYPH cord-006252-cbelsymu 139 35 lasting last VBG cord-006252-cbelsymu 139 36 immunity immunity NN cord-006252-cbelsymu 139 37 . . . cord-006252-cbelsymu 140 1 Why why WRB cord-006252-cbelsymu 140 2 the the DT cord-006252-cbelsymu 140 3 difference difference NN cord-006252-cbelsymu 140 4 ? ? . cord-006252-cbelsymu 141 1 There there EX cord-006252-cbelsymu 141 2 is be VBZ cord-006252-cbelsymu 141 3 only only RB cord-006252-cbelsymu 141 4 I -PRON- PRP cord-006252-cbelsymu 141 5 strain strain VBP cord-006252-cbelsymu 141 6 of of IN cord-006252-cbelsymu 141 7 measles measle NNS cord-006252-cbelsymu 141 8 and and CC cord-006252-cbelsymu 141 9 its -PRON- PRP$ cord-006252-cbelsymu 141 10 nonsegmented nonsegmente VBN cord-006252-cbelsymu 141 11 genome genome NN cord-006252-cbelsymu 141 12 preserves preserve VBZ cord-006252-cbelsymu 141 13 its -PRON- PRP$ cord-006252-cbelsymu 141 14 singularity singularity NN cord-006252-cbelsymu 141 15 . . . cord-006252-cbelsymu 142 1 Influenza influenza NN cord-006252-cbelsymu 142 2 virus virus NN cord-006252-cbelsymu 142 3 , , , cord-006252-cbelsymu 142 4 on on IN cord-006252-cbelsymu 142 5 the the DT cord-006252-cbelsymu 142 6 other other JJ cord-006252-cbelsymu 142 7 hand hand NN cord-006252-cbelsymu 142 8 , , , cord-006252-cbelsymu 142 9 has have VBZ cord-006252-cbelsymu 142 10 a a DT cord-006252-cbelsymu 142 11 segmented segmented JJ cord-006252-cbelsymu 142 12 genome genome NN cord-006252-cbelsymu 142 13 . . . cord-006252-cbelsymu 143 1 The the DT cord-006252-cbelsymu 143 2 multiple multiple JJ cord-006252-cbelsymu 143 3 RNA RNA NNP cord-006252-cbelsymu 143 4 segments segment NNS cord-006252-cbelsymu 143 5 -there -there JJS cord-006252-cbelsymu 143 6 are be VBP cord-006252-cbelsymu 143 7 8 8 CD cord-006252-cbelsymu 143 8 in in IN cord-006252-cbelsymu 143 9 all all DT cord-006252-cbelsymu 143 10 -predispose -predispose '' cord-006252-cbelsymu 143 11 to to IN cord-006252-cbelsymu 143 12 the the DT cord-006252-cbelsymu 143 13 genetic genetic JJ cord-006252-cbelsymu 143 14 instability instability NN cord-006252-cbelsymu 143 15 of of IN cord-006252-cbelsymu 143 16 the the DT cord-006252-cbelsymu 143 17 influenza influenza NN cord-006252-cbelsymu 143 18 virus virus NN cord-006252-cbelsymu 143 19 ( ( -LRB- cord-006252-cbelsymu 143 20 table table NN cord-006252-cbelsymu 143 21 I -PRON- PRP cord-006252-cbelsymu 143 22 , , , cord-006252-cbelsymu 143 23 fig fig NN cord-006252-cbelsymu 143 24 . . NNP cord-006252-cbelsymu 143 25 2 2 CD cord-006252-cbelsymu 143 26 ) ) -RRB- cord-006252-cbelsymu 143 27 . . . cord-006252-cbelsymu 144 1 The the DT cord-006252-cbelsymu 144 2 nucleotide nucleotide JJ cord-006252-cbelsymu 144 3 sequences sequence NNS cord-006252-cbelsymu 144 4 in in IN cord-006252-cbelsymu 144 5 the the DT cord-006252-cbelsymu 144 6 RNA RNA NNP cord-006252-cbelsymu 144 7 segments segment NNS cord-006252-cbelsymu 144 8 are be VBP cord-006252-cbelsymu 144 9 inherently inherently RB cord-006252-cbelsymu 144 10 unstable unstable JJ cord-006252-cbelsymu 144 11 , , , cord-006252-cbelsymu 144 12 and and CC cord-006252-cbelsymu 144 13 when when WRB cord-006252-cbelsymu 144 14 2 2 CD cord-006252-cbelsymu 144 15 different different JJ cord-006252-cbelsymu 144 16 strains strain NNS cord-006252-cbelsymu 144 17 of of IN cord-006252-cbelsymu 144 18 the the DT cord-006252-cbelsymu 144 19 same same JJ cord-006252-cbelsymu 144 20 subtype subtype NN cord-006252-cbelsymu 144 21 infect infect VBP cord-006252-cbelsymu 144 22 the the DT cord-006252-cbelsymu 144 23 same same JJ cord-006252-cbelsymu 144 24 host host NN cord-006252-cbelsymu 144 25 the the DT cord-006252-cbelsymu 144 26 RNA RNA NNP cord-006252-cbelsymu 144 27 segments segment NNS cord-006252-cbelsymu 144 28 can can MD cord-006252-cbelsymu 144 29 reassort reassort VB cord-006252-cbelsymu 144 30 , , , cord-006252-cbelsymu 144 31 giving give VBG cord-006252-cbelsymu 144 32 rise rise NN cord-006252-cbelsymu 144 33 to to IN cord-006252-cbelsymu 144 34 progeny progeny VB cord-006252-cbelsymu 144 35 that that WDT cord-006252-cbelsymu 144 36 are be VBP cord-006252-cbelsymu 144 37 different different JJ cord-006252-cbelsymu 144 38 from from IN cord-006252-cbelsymu 144 39 the the DT cord-006252-cbelsymu 144 40 2 2 CD cord-006252-cbelsymu 144 41 parents parent NNS cord-006252-cbelsymu 144 42 . . . cord-006252-cbelsymu 145 1 The the DT cord-006252-cbelsymu 145 2 naming naming NN cord-006252-cbelsymu 145 3 of of IN cord-006252-cbelsymu 145 4 influenza influenza NN cord-006252-cbelsymu 145 5 viruses virus NNS cord-006252-cbelsymu 145 6 is be VBZ cord-006252-cbelsymu 145 7 straightforward straightforward JJ cord-006252-cbelsymu 145 8 . . . cord-006252-cbelsymu 146 1 For for IN cord-006252-cbelsymu 146 2 example example NN cord-006252-cbelsymu 146 3 , , , cord-006252-cbelsymu 146 4 influenza influenza NN cord-006252-cbelsymu 146 5 A a NN cord-006252-cbelsymu 146 6 / / SYM cord-006252-cbelsymu 146 7 Shanghai/16/89 shanghai/16/89 NN cord-006252-cbelsymu 146 8 ( ( -LRB- cord-006252-cbelsymu 146 9 H3N2 H3N2 NNP cord-006252-cbelsymu 146 10 ) ) -RRB- cord-006252-cbelsymu 146 11 is be VBZ cord-006252-cbelsymu 146 12 so so RB cord-006252-cbelsymu 146 13 named name VBN cord-006252-cbelsymu 146 14 because because IN cord-006252-cbelsymu 146 15 this this DT cord-006252-cbelsymu 146 16 strain strain NN cord-006252-cbelsymu 146 17 is be VBZ cord-006252-cbelsymu 146 18 a a DT cord-006252-cbelsymu 146 19 type type NN cord-006252-cbelsymu 146 20 A a DT cord-006252-cbelsymu 146 21 influenza influenza NN cord-006252-cbelsymu 146 22 virus virus NN cord-006252-cbelsymu 146 23 first first RB cord-006252-cbelsymu 146 24 isolated isolate VBN cord-006252-cbelsymu 146 25 in in IN cord-006252-cbelsymu 146 26 Shanghai Shanghai NNP cord-006252-cbelsymu 146 27 in in IN cord-006252-cbelsymu 146 28 1989 1989 CD cord-006252-cbelsymu 146 29 . . . cord-006252-cbelsymu 147 1 It -PRON- PRP cord-006252-cbelsymu 147 2 was be VBD cord-006252-cbelsymu 147 3 the the DT cord-006252-cbelsymu 147 4 sixteenth sixteenth JJ cord-006252-cbelsymu 147 5 isolate isolate NN cord-006252-cbelsymu 147 6 of of IN cord-006252-cbelsymu 147 7 the the DT cord-006252-cbelsymu 147 8 subtype subtype NN cord-006252-cbelsymu 147 9 H3N2 H3N2 NNP cord-006252-cbelsymu 147 10 detected detect VBD cord-006252-cbelsymu 147 11 in in IN cord-006252-cbelsymu 147 12 that that DT cord-006252-cbelsymu 147 13 year year NN cord-006252-cbelsymu 147 14 . . . cord-006252-cbelsymu 148 1 Haemagglutinin Haemagglutinin NNP cord-006252-cbelsymu 148 2 ( ( -LRB- cord-006252-cbelsymu 148 3 H H NNP cord-006252-cbelsymu 148 4 ) ) -RRB- cord-006252-cbelsymu 148 5 and and CC cord-006252-cbelsymu 148 6 neuraminidase neuraminidase NN cord-006252-cbelsymu 148 7 ( ( -LRB- cord-006252-cbelsymu 148 8 N n NN cord-006252-cbelsymu 148 9 ) ) -RRB- cord-006252-cbelsymu 148 10 proteins protein NNS cord-006252-cbelsymu 148 11 exist exist VBP cord-006252-cbelsymu 148 12 in in IN cord-006252-cbelsymu 148 13 types type NNS cord-006252-cbelsymu 148 14 A A NNP cord-006252-cbelsymu 148 15 , , , cord-006252-cbelsymu 148 16 B b NN cord-006252-cbelsymu 148 17 , , , cord-006252-cbelsymu 148 18 and and CC cord-006252-cbelsymu 148 19 C C NNP cord-006252-cbelsymu 148 20 influenza influenza NN cord-006252-cbelsymu 148 21 virus virus NN cord-006252-cbelsymu 148 22 . . . cord-006252-cbelsymu 149 1 But but CC cord-006252-cbelsymu 149 2 only only RB cord-006252-cbelsymu 149 3 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 149 4 and and CC cord-006252-cbelsymu 149 5 neuraminidase neuraminidase NN cord-006252-cbelsymu 149 6 proteins protein NNS cord-006252-cbelsymu 149 7 of of IN cord-006252-cbelsymu 149 8 influenza influenza NN cord-006252-cbelsymu 149 9 A a NN cord-006252-cbelsymu 149 10 are be VBP cord-006252-cbelsymu 149 11 sufficiently sufficiently RB cord-006252-cbelsymu 149 12 diverse diverse JJ cord-006252-cbelsymu 149 13 to to TO cord-006252-cbelsymu 149 14 warrant warrant VB cord-006252-cbelsymu 149 15 subtype subtype NN cord-006252-cbelsymu 149 16 designations designation NNS cord-006252-cbelsymu 149 17 . . . cord-006252-cbelsymu 150 1 For for IN cord-006252-cbelsymu 150 2 the the DT cord-006252-cbelsymu 150 3 type type NN cord-006252-cbelsymu 150 4 A a DT cord-006252-cbelsymu 150 5 influenza influenza NN cord-006252-cbelsymu 150 6 viruses virus NNS cord-006252-cbelsymu 150 7 , , , cord-006252-cbelsymu 150 8 3 3 CD cord-006252-cbelsymu 150 9 haemagglutinins haemagglutinin NNS cord-006252-cbelsymu 150 10 ( ( -LRB- cord-006252-cbelsymu 150 11 H\ H\ NNP cord-006252-cbelsymu 150 12 , , , cord-006252-cbelsymu 150 13 H2 H2 NNP cord-006252-cbelsymu 150 14 and and CC cord-006252-cbelsymu 150 15 H3 H3 NNP cord-006252-cbelsymu 150 16 ) ) -RRB- cord-006252-cbelsymu 150 17 and and CC cord-006252-cbelsymu 150 18 2 2 CD cord-006252-cbelsymu 150 19 neuraminidases neuraminidase NNS cord-006252-cbelsymu 150 20 ( ( -LRB- cord-006252-cbelsymu 150 21 N N NNP cord-006252-cbelsymu 150 22 \ \ NNP cord-006252-cbelsymu 150 23 and and CC cord-006252-cbelsymu 150 24 N2 N2 NNP cord-006252-cbelsymu 150 25 ) ) -RRB- cord-006252-cbelsymu 150 26 have have VBP cord-006252-cbelsymu 150 27 been be VBN cord-006252-cbelsymu 150 28 described describe VBN cord-006252-cbelsymu 150 29 . . . cord-006252-cbelsymu 151 1 Currently currently RB cord-006252-cbelsymu 151 2 , , , cord-006252-cbelsymu 151 3 only only RB cord-006252-cbelsymu 151 4 2 2 CD cord-006252-cbelsymu 151 5 subtypes subtype NNS cord-006252-cbelsymu 151 6 of of IN cord-006252-cbelsymu 151 7 influenza influenza NN cord-006252-cbelsymu 151 8 A a NN cord-006252-cbelsymu 151 9 are be VBP cord-006252-cbelsymu 151 10 circulating circulate VBG cord-006252-cbelsymu 151 11 and and CC cord-006252-cbelsymu 151 12 causing cause VBG cord-006252-cbelsymu 151 13 disease disease NN cord-006252-cbelsymu 151 14 in in IN cord-006252-cbelsymu 151 15 humans human NNS cord-006252-cbelsymu 151 16 , , , cord-006252-cbelsymu 151 17 and and CC cord-006252-cbelsymu 151 18 they -PRON- PRP cord-006252-cbelsymu 151 19 are be VBP cord-006252-cbelsymu 151 20 the the DT cord-006252-cbelsymu 151 21 H3N2 H3N2 NNP cord-006252-cbelsymu 151 22 and and CC cord-006252-cbelsymu 151 23 the the DT cord-006252-cbelsymu 151 24 HIN\ HIN\ NNP cord-006252-cbelsymu 151 25 subtypes subtype NNS cord-006252-cbelsymu 151 26 . . . cord-006252-cbelsymu 152 1 The the DT cord-006252-cbelsymu 152 2 genetic genetic JJ cord-006252-cbelsymu 152 3 changes change NNS cord-006252-cbelsymu 152 4 that that WDT cord-006252-cbelsymu 152 5 occur occur VBP cord-006252-cbelsymu 152 6 have have VBP cord-006252-cbelsymu 152 7 been be VBN cord-006252-cbelsymu 152 8 referred refer VBN cord-006252-cbelsymu 152 9 to to IN cord-006252-cbelsymu 152 10 by by IN cord-006252-cbelsymu 152 11 the the DT cord-006252-cbelsymu 152 12 terms term NNS cord-006252-cbelsymu 152 13 antigenic antigenic JJ cord-006252-cbelsymu 152 14 drift drift NN cord-006252-cbelsymu 152 15 and and CC cord-006252-cbelsymu 152 16 antigenic antigenic JJ cord-006252-cbelsymu 152 17 shift shift NN cord-006252-cbelsymu 152 18 . . . cord-006252-cbelsymu 153 1 Antigenic antigenic JJ cord-006252-cbelsymu 153 2 drift drift NN cord-006252-cbelsymu 153 3 is be VBZ cord-006252-cbelsymu 153 4 a a DT cord-006252-cbelsymu 153 5 minor minor JJ cord-006252-cbelsymu 153 6 change change NN cord-006252-cbelsymu 153 7 that that WDT cord-006252-cbelsymu 153 8 occurs occur VBZ cord-006252-cbelsymu 153 9 ( ( -LRB- cord-006252-cbelsymu 153 10 H3N2 H3N2 NNP cord-006252-cbelsymu 153 11 ) ) -RRB- cord-006252-cbelsymu 153 12 is be VBZ cord-006252-cbelsymu 153 13 an an DT cord-006252-cbelsymu 153 14 example example NN cord-006252-cbelsymu 153 15 of of IN cord-006252-cbelsymu 153 16 this this DT cord-006252-cbelsymu 153 17 . . . cord-006252-cbelsymu 154 1 Minor minor JJ cord-006252-cbelsymu 154 2 changes change NNS cord-006252-cbelsymu 154 3 also also RB cord-006252-cbelsymu 154 4 occur occur VBP cord-006252-cbelsymu 154 5 when when WRB cord-006252-cbelsymu 154 6 antigens antigen NNS cord-006252-cbelsymu 154 7 are be VBP cord-006252-cbelsymu 154 8 glycosylated glycosylate VBN cord-006252-cbelsymu 154 9 and and CC cord-006252-cbelsymu 154 10 camouflage camouflage VB cord-006252-cbelsymu 154 11 the the DT cord-006252-cbelsymu 154 12 previously previously RB cord-006252-cbelsymu 154 13 exposed expose VBN cord-006252-cbelsymu 154 14 antigenic antigenic JJ cord-006252-cbelsymu 154 15 site site NN cord-006252-cbelsymu 154 16 . . . cord-006252-cbelsymu 155 1 Antigenic antigenic JJ cord-006252-cbelsymu 155 2 shift shift NN cord-006252-cbelsymu 155 3 is be VBZ cord-006252-cbelsymu 155 4 a a DT cord-006252-cbelsymu 155 5 major major JJ cord-006252-cbelsymu 155 6 change change NN cord-006252-cbelsymu 155 7 that that WDT cord-006252-cbelsymu 155 8 occurs occur VBZ cord-006252-cbelsymu 155 9 by by IN cord-006252-cbelsymu 155 10 gene gene NN cord-006252-cbelsymu 155 11 reassortment reassortment NN cord-006252-cbelsymu 155 12 resulting result VBG cord-006252-cbelsymu 155 13 in in IN cord-006252-cbelsymu 155 14 a a DT cord-006252-cbelsymu 155 15 new new JJ cord-006252-cbelsymu 155 16 subtype subtype NN cord-006252-cbelsymu 155 17 . . . cord-006252-cbelsymu 156 1 The the DT cord-006252-cbelsymu 156 2 change change NN cord-006252-cbelsymu 156 3 from from IN cord-006252-cbelsymu 156 4 the the DT cord-006252-cbelsymu 156 5 influenza influenza NN cord-006252-cbelsymu 156 6 A a NN cord-006252-cbelsymu 156 7 ( ( -LRB- cord-006252-cbelsymu 156 8 H2N2 H2N2 NNP cord-006252-cbelsymu 156 9 ) ) -RRB- cord-006252-cbelsymu 156 10 to to IN cord-006252-cbelsymu 156 11 the the DT cord-006252-cbelsymu 156 12 influenza influenza NN cord-006252-cbelsymu 156 13 A a NN cord-006252-cbelsymu 156 14 ( ( -LRB- cord-006252-cbelsymu 156 15 H3N2 H3N2 NNP cord-006252-cbelsymu 156 16 ) ) -RRB- cord-006252-cbelsymu 156 17 subtype subtype NN cord-006252-cbelsymu 156 18 that that WDT cord-006252-cbelsymu 156 19 occurred occur VBD cord-006252-cbelsymu 156 20 in in IN cord-006252-cbelsymu 156 21 1968 1968 CD cord-006252-cbelsymu 156 22 is be VBZ cord-006252-cbelsymu 156 23 such such PDT cord-006252-cbelsymu 156 24 an an DT cord-006252-cbelsymu 156 25 example example NN cord-006252-cbelsymu 156 26 . . . cord-006252-cbelsymu 157 1 Gene gene NN cord-006252-cbelsymu 157 2 reassortment reassortment NN cord-006252-cbelsymu 157 3 probably probably RB cord-006252-cbelsymu 157 4 occurs occur VBZ cord-006252-cbelsymu 157 5 when when WRB cord-006252-cbelsymu 157 6 2 2 CD cord-006252-cbelsymu 157 7 different different JJ cord-006252-cbelsymu 157 8 subtypes subtype NNS cord-006252-cbelsymu 157 9 coinfect coinfect VBP cord-006252-cbelsymu 157 10 the the DT cord-006252-cbelsymu 157 11 same same JJ cord-006252-cbelsymu 157 12 host host NN cord-006252-cbelsymu 157 13 . . . cord-006252-cbelsymu 158 1 Serum serum NN cord-006252-cbelsymu 158 2 antibody antibody NN cord-006252-cbelsymu 158 3 to to IN cord-006252-cbelsymu 158 4 the the DT cord-006252-cbelsymu 158 5 surface surface NN cord-006252-cbelsymu 158 6 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 158 7 and and CC cord-006252-cbelsymu 159 1 neuraminidase neuraminidase NN cord-006252-cbelsymu 159 2 proteins protein NNS cord-006252-cbelsymu 159 3 is be VBZ cord-006252-cbelsymu 159 4 important important JJ cord-006252-cbelsymu 159 5 in in IN cord-006252-cbelsymu 159 6 protection protection NN cord-006252-cbelsymu 159 7 against against IN cord-006252-cbelsymu 159 8 infection infection NN cord-006252-cbelsymu 159 9 and and CC cord-006252-cbelsymu 159 10 the the DT cord-006252-cbelsymu 159 11 development development NN cord-006252-cbelsymu 159 12 of of IN cord-006252-cbelsymu 159 13 disease disease NN cord-006252-cbelsymu 159 14 . . . cord-006252-cbelsymu 160 1 Humoral Humoral NNP cord-006252-cbelsymu 160 2 antibody antibody NN cord-006252-cbelsymu 160 3 to to IN cord-006252-cbelsymu 160 4 the the DT cord-006252-cbelsymu 160 5 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 160 6 component component NN cord-006252-cbelsymu 160 7 is be VBZ cord-006252-cbelsymu 160 8 the the DT cord-006252-cbelsymu 160 9 most most RBS cord-006252-cbelsymu 160 10 critical critical JJ cord-006252-cbelsymu 160 11 , , , cord-006252-cbelsymu 160 12 but but CC cord-006252-cbelsymu 160 13 the the DT cord-006252-cbelsymu 160 14 importance importance NN cord-006252-cbelsymu 160 15 of of IN cord-006252-cbelsymu 160 16 cell cell NN cord-006252-cbelsymu 160 17 - - HYPH cord-006252-cbelsymu 160 18 mediated mediate VBN cord-006252-cbelsymu 160 19 immunity immunity NN cord-006252-cbelsymu 160 20 is be VBZ cord-006252-cbelsymu 160 21 less less RBR cord-006252-cbelsymu 160 22 clear clear JJ cord-006252-cbelsymu 160 23 . . . cord-006252-cbelsymu 161 1 The the DT cord-006252-cbelsymu 161 2 humoral humoral JJ cord-006252-cbelsymu 161 3 immune immune JJ cord-006252-cbelsymu 161 4 response response NN cord-006252-cbelsymu 161 5 is be VBZ cord-006252-cbelsymu 161 6 highly highly RB cord-006252-cbelsymu 161 7 specific specific JJ cord-006252-cbelsymu 161 8 for for IN cord-006252-cbelsymu 161 9 certain certain JJ cord-006252-cbelsymu 161 10 epitopes epitope NNS cord-006252-cbelsymu 161 11 on on IN cord-006252-cbelsymu 161 12 the the DT cord-006252-cbelsymu 161 13 surface surface NN cord-006252-cbelsymu 161 14 of of IN cord-006252-cbelsymu 161 15 the the DT cord-006252-cbelsymu 161 16 virus virus NN cord-006252-cbelsymu 161 17 . . . cord-006252-cbelsymu 162 1 The the DT cord-006252-cbelsymu 162 2 cellular cellular JJ cord-006252-cbelsymu 162 3 response response NN cord-006252-cbelsymu 162 4 , , , cord-006252-cbelsymu 162 5 in in IN cord-006252-cbelsymu 162 6 contrast contrast NN cord-006252-cbelsymu 162 7 , , , cord-006252-cbelsymu 162 8 is be VBZ cord-006252-cbelsymu 162 9 less less RBR cord-006252-cbelsymu 162 10 specific specific JJ cord-006252-cbelsymu 162 11 and and CC cord-006252-cbelsymu 162 12 more more RBR cord-006252-cbelsymu 162 13 cross cross JJ cord-006252-cbelsymu 162 14 - - JJ cord-006252-cbelsymu 162 15 reactive reactive JJ cord-006252-cbelsymu 162 16 . . . cord-006252-cbelsymu 163 1 The the DT cord-006252-cbelsymu 163 2 B b NN cord-006252-cbelsymu 163 3 cells cell NNS cord-006252-cbelsymu 163 4 which which WDT cord-006252-cbelsymu 163 5 produce produce VBP cord-006252-cbelsymu 163 6 humoral humoral JJ cord-006252-cbelsymu 163 7 antibody antibody NN cord-006252-cbelsymu 163 8 recognise recognise VB cord-006252-cbelsymu 163 9 antigenic antigenic JJ cord-006252-cbelsymu 163 10 determinants determinant NNS cord-006252-cbelsymu 163 11 , , , cord-006252-cbelsymu 163 12 or or CC cord-006252-cbelsymu 163 13 epitopes epitope NNS cord-006252-cbelsymu 163 14 , , , cord-006252-cbelsymu 163 15 adjacent adjacent JJ cord-006252-cbelsymu 163 16 in in IN cord-006252-cbelsymu 163 17 space space NN cord-006252-cbelsymu 163 18 but but CC cord-006252-cbelsymu 163 19 not not RB cord-006252-cbelsymu 163 20 in in IN cord-006252-cbelsymu 163 21 sequence sequence NN cord-006252-cbelsymu 163 22 , , , cord-006252-cbelsymu 163 23 while while IN cord-006252-cbelsymu 163 24 T t NN cord-006252-cbelsymu 163 25 cells cell NNS cord-006252-cbelsymu 163 26 recognise recognise VBP cord-006252-cbelsymu 163 27 epitopes epitope NNS cord-006252-cbelsymu 163 28 adjacent adjacent JJ cord-006252-cbelsymu 163 29 in in IN cord-006252-cbelsymu 163 30 sequence sequence NN cord-006252-cbelsymu 163 31 but but CC cord-006252-cbelsymu 163 32 not not RB cord-006252-cbelsymu 163 33 necessarily necessarily RB cord-006252-cbelsymu 163 34 in in IN cord-006252-cbelsymu 163 35 space space NN cord-006252-cbelsymu 163 36 . . . cord-006252-cbelsymu 164 1 The the DT cord-006252-cbelsymu 164 2 434 434 CD cord-006252-cbelsymu 164 3 singularity singularity NN cord-006252-cbelsymu 164 4 . . . cord-006252-cbelsymu 165 1 Influenza influenza NN cord-006252-cbelsymu 165 2 virus virus NN cord-006252-cbelsymu 165 3 , , , cord-006252-cbelsymu 165 4 on on IN cord-006252-cbelsymu 165 5 the the DT cord-006252-cbelsymu 165 6 other other JJ cord-006252-cbelsymu 165 7 hand hand NN cord-006252-cbelsymu 165 8 , , , cord-006252-cbelsymu 165 9 has have VBZ cord-006252-cbelsymu 165 10 a a DT cord-006252-cbelsymu 165 11 segmented segmented JJ cord-006252-cbelsymu 165 12 genome genome NN cord-006252-cbelsymu 165 13 . . . cord-006252-cbelsymu 166 1 The the DT cord-006252-cbelsymu 166 2 multiple multiple JJ cord-006252-cbelsymu 166 3 RNA RNA NNP cord-006252-cbelsymu 166 4 segments segment NNS cord-006252-cbelsymu 166 5 -there -there JJS cord-006252-cbelsymu 166 6 are be VBP cord-006252-cbelsymu 166 7 8 8 CD cord-006252-cbelsymu 166 8 in in IN cord-006252-cbelsymu 166 9 all all DT cord-006252-cbelsymu 166 10 -predispose -predispose '' cord-006252-cbelsymu 166 11 to to IN cord-006252-cbelsymu 166 12 the the DT cord-006252-cbelsymu 166 13 genetic genetic JJ cord-006252-cbelsymu 166 14 instability instability NN cord-006252-cbelsymu 166 15 of of IN cord-006252-cbelsymu 166 16 the the DT cord-006252-cbelsymu 166 17 influenza influenza NN cord-006252-cbelsymu 166 18 virus virus NN cord-006252-cbelsymu 166 19 ( ( -LRB- cord-006252-cbelsymu 166 20 table table NN cord-006252-cbelsymu 166 21 I -PRON- PRP cord-006252-cbelsymu 166 22 , , , cord-006252-cbelsymu 166 23 fig fig NN cord-006252-cbelsymu 166 24 . . NNP cord-006252-cbelsymu 166 25 2 2 CD cord-006252-cbelsymu 166 26 ) ) -RRB- cord-006252-cbelsymu 166 27 . . . cord-006252-cbelsymu 167 1 The the DT cord-006252-cbelsymu 167 2 nucleotide nucleotide JJ cord-006252-cbelsymu 167 3 sequences sequence NNS cord-006252-cbelsymu 167 4 in in IN cord-006252-cbelsymu 167 5 the the DT cord-006252-cbelsymu 167 6 RNA RNA NNP cord-006252-cbelsymu 167 7 segments segment NNS cord-006252-cbelsymu 167 8 are be VBP cord-006252-cbelsymu 167 9 inherently inherently RB cord-006252-cbelsymu 167 10 unstable unstable JJ cord-006252-cbelsymu 167 11 , , , cord-006252-cbelsymu 167 12 and and CC cord-006252-cbelsymu 167 13 when when WRB cord-006252-cbelsymu 167 14 2 2 CD cord-006252-cbelsymu 167 15 different different JJ cord-006252-cbelsymu 167 16 strains strain NNS cord-006252-cbelsymu 167 17 of of IN cord-006252-cbelsymu 167 18 the the DT cord-006252-cbelsymu 167 19 same same JJ cord-006252-cbelsymu 167 20 subtype subtype NN cord-006252-cbelsymu 167 21 infect infect VBP cord-006252-cbelsymu 167 22 the the DT cord-006252-cbelsymu 167 23 same same JJ cord-006252-cbelsymu 167 24 host host NN cord-006252-cbelsymu 167 25 the the DT cord-006252-cbelsymu 167 26 RNA RNA NNP cord-006252-cbelsymu 167 27 segments segment NNS cord-006252-cbelsymu 167 28 can can MD cord-006252-cbelsymu 167 29 reassort reassort VB cord-006252-cbelsymu 167 30 , , , cord-006252-cbelsymu 167 31 giving give VBG cord-006252-cbelsymu 167 32 rise rise NN cord-006252-cbelsymu 167 33 to to IN cord-006252-cbelsymu 167 34 progeny progeny VB cord-006252-cbelsymu 167 35 that that WDT cord-006252-cbelsymu 167 36 are be VBP cord-006252-cbelsymu 167 37 different different JJ cord-006252-cbelsymu 167 38 from from IN cord-006252-cbelsymu 167 39 the the DT cord-006252-cbelsymu 167 40 2 2 CD cord-006252-cbelsymu 167 41 parents parent NNS cord-006252-cbelsymu 167 42 . . . cord-006252-cbelsymu 168 1 The the DT cord-006252-cbelsymu 168 2 naming naming NN cord-006252-cbelsymu 168 3 of of IN cord-006252-cbelsymu 168 4 influenza influenza NN cord-006252-cbelsymu 168 5 viruses virus NNS cord-006252-cbelsymu 168 6 is be VBZ cord-006252-cbelsymu 168 7 straightforward straightforward JJ cord-006252-cbelsymu 168 8 . . . cord-006252-cbelsymu 169 1 For for IN cord-006252-cbelsymu 169 2 example example NN cord-006252-cbelsymu 169 3 , , , cord-006252-cbelsymu 169 4 influenza influenza NN cord-006252-cbelsymu 169 5 A a NN cord-006252-cbelsymu 169 6 / / SYM cord-006252-cbelsymu 169 7 Shanghai/16/89 shanghai/16/89 NN cord-006252-cbelsymu 169 8 ( ( -LRB- cord-006252-cbelsymu 169 9 H3N2 H3N2 NNP cord-006252-cbelsymu 169 10 ) ) -RRB- cord-006252-cbelsymu 169 11 is be VBZ cord-006252-cbelsymu 169 12 so so RB cord-006252-cbelsymu 169 13 named name VBN cord-006252-cbelsymu 169 14 because because IN cord-006252-cbelsymu 169 15 this this DT cord-006252-cbelsymu 169 16 strain strain NN cord-006252-cbelsymu 169 17 is be VBZ cord-006252-cbelsymu 169 18 a a DT cord-006252-cbelsymu 169 19 type type NN cord-006252-cbelsymu 169 20 A a DT cord-006252-cbelsymu 169 21 influenza influenza NN cord-006252-cbelsymu 169 22 virus virus NN cord-006252-cbelsymu 169 23 first first RB cord-006252-cbelsymu 169 24 isolated isolate VBN cord-006252-cbelsymu 169 25 in in IN cord-006252-cbelsymu 169 26 Shanghai Shanghai NNP cord-006252-cbelsymu 169 27 in in IN cord-006252-cbelsymu 169 28 1989 1989 CD cord-006252-cbelsymu 169 29 . . . cord-006252-cbelsymu 170 1 It -PRON- PRP cord-006252-cbelsymu 170 2 was be VBD cord-006252-cbelsymu 170 3 the the DT cord-006252-cbelsymu 170 4 sixteenth sixteenth JJ cord-006252-cbelsymu 170 5 isolate isolate NN cord-006252-cbelsymu 170 6 of of IN cord-006252-cbelsymu 170 7 the the DT cord-006252-cbelsymu 170 8 subtype subtype NN cord-006252-cbelsymu 170 9 H3N2 H3N2 NNP cord-006252-cbelsymu 170 10 detected detect VBD cord-006252-cbelsymu 170 11 in in IN cord-006252-cbelsymu 170 12 that that DT cord-006252-cbelsymu 170 13 year year NN cord-006252-cbelsymu 170 14 . . . cord-006252-cbelsymu 171 1 Haemagglutinin Haemagglutinin NNP cord-006252-cbelsymu 171 2 ( ( -LRB- cord-006252-cbelsymu 171 3 H H NNP cord-006252-cbelsymu 171 4 ) ) -RRB- cord-006252-cbelsymu 171 5 and and CC cord-006252-cbelsymu 171 6 neuraminidase neuraminidase NN cord-006252-cbelsymu 171 7 ( ( -LRB- cord-006252-cbelsymu 171 8 N n NN cord-006252-cbelsymu 171 9 ) ) -RRB- cord-006252-cbelsymu 171 10 proteins protein NNS cord-006252-cbelsymu 171 11 exist exist VBP cord-006252-cbelsymu 171 12 in in IN cord-006252-cbelsymu 171 13 types type NNS cord-006252-cbelsymu 171 14 A A NNP cord-006252-cbelsymu 171 15 , , , cord-006252-cbelsymu 171 16 B b NN cord-006252-cbelsymu 171 17 , , , cord-006252-cbelsymu 171 18 and and CC cord-006252-cbelsymu 171 19 C C NNP cord-006252-cbelsymu 171 20 influenza influenza NN cord-006252-cbelsymu 171 21 virus virus NN cord-006252-cbelsymu 171 22 . . . cord-006252-cbelsymu 172 1 But but CC cord-006252-cbelsymu 172 2 only only RB cord-006252-cbelsymu 172 3 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 172 4 and and CC cord-006252-cbelsymu 172 5 neuraminidase neuraminidase NN cord-006252-cbelsymu 172 6 proteins protein NNS cord-006252-cbelsymu 172 7 of of IN cord-006252-cbelsymu 172 8 influenza influenza NN cord-006252-cbelsymu 172 9 A a NN cord-006252-cbelsymu 172 10 are be VBP cord-006252-cbelsymu 172 11 sufficiently sufficiently RB cord-006252-cbelsymu 172 12 diverse diverse JJ cord-006252-cbelsymu 172 13 to to TO cord-006252-cbelsymu 172 14 warrant warrant VB cord-006252-cbelsymu 172 15 subtype subtype NN cord-006252-cbelsymu 172 16 designations designation NNS cord-006252-cbelsymu 172 17 . . . cord-006252-cbelsymu 173 1 For for IN cord-006252-cbelsymu 173 2 the the DT cord-006252-cbelsymu 173 3 type type NN cord-006252-cbelsymu 173 4 A a DT cord-006252-cbelsymu 173 5 influenza influenza NN cord-006252-cbelsymu 173 6 viruses virus NNS cord-006252-cbelsymu 173 7 , , , cord-006252-cbelsymu 173 8 3 3 CD cord-006252-cbelsymu 173 9 haemagglutinins haemagglutinin NNS cord-006252-cbelsymu 173 10 ( ( -LRB- cord-006252-cbelsymu 173 11 HI hi UH cord-006252-cbelsymu 173 12 , , , cord-006252-cbelsymu 173 13 H2 H2 NNP cord-006252-cbelsymu 173 14 and and CC cord-006252-cbelsymu 173 15 H3 H3 NNP cord-006252-cbelsymu 173 16 ) ) -RRB- cord-006252-cbelsymu 173 17 and and CC cord-006252-cbelsymu 173 18 2 2 CD cord-006252-cbelsymu 173 19 neuraminidases neuraminidase NNS cord-006252-cbelsymu 173 20 ( ( -LRB- cord-006252-cbelsymu 173 21 N n CC cord-006252-cbelsymu 173 22 I I NNP cord-006252-cbelsymu 173 23 and and CC cord-006252-cbelsymu 173 24 N2 N2 NNP cord-006252-cbelsymu 173 25 ) ) -RRB- cord-006252-cbelsymu 173 26 have have VBP cord-006252-cbelsymu 173 27 been be VBN cord-006252-cbelsymu 173 28 described describe VBN cord-006252-cbelsymu 173 29 . . . cord-006252-cbelsymu 174 1 Currently currently RB cord-006252-cbelsymu 174 2 , , , cord-006252-cbelsymu 174 3 only only RB cord-006252-cbelsymu 174 4 2 2 CD cord-006252-cbelsymu 174 5 subtypes subtype NNS cord-006252-cbelsymu 174 6 of of IN cord-006252-cbelsymu 174 7 influenza influenza NN cord-006252-cbelsymu 174 8 A a NN cord-006252-cbelsymu 174 9 are be VBP cord-006252-cbelsymu 174 10 circulating circulate VBG cord-006252-cbelsymu 174 11 and and CC cord-006252-cbelsymu 174 12 causing cause VBG cord-006252-cbelsymu 174 13 disease disease NN cord-006252-cbelsymu 174 14 in in IN cord-006252-cbelsymu 174 15 humans human NNS cord-006252-cbelsymu 174 16 , , , cord-006252-cbelsymu 174 17 and and CC cord-006252-cbelsymu 174 18 they -PRON- PRP cord-006252-cbelsymu 174 19 are be VBP cord-006252-cbelsymu 174 20 the the DT cord-006252-cbelsymu 174 21 H3N2 H3N2 NNP cord-006252-cbelsymu 174 22 and and CC cord-006252-cbelsymu 174 23 the the DT cord-006252-cbelsymu 174 24 HIN HIN NNP cord-006252-cbelsymu 174 25 I -PRON- PRP cord-006252-cbelsymu 174 26 subtypes subtypes VBP cord-006252-cbelsymu 174 27 . . . cord-006252-cbelsymu 175 1 The the DT cord-006252-cbelsymu 175 2 genetic genetic JJ cord-006252-cbelsymu 175 3 changes change NNS cord-006252-cbelsymu 175 4 that that WDT cord-006252-cbelsymu 175 5 occur occur VBP cord-006252-cbelsymu 175 6 have have VBP cord-006252-cbelsymu 175 7 been be VBN cord-006252-cbelsymu 175 8 referred refer VBN cord-006252-cbelsymu 175 9 to to IN cord-006252-cbelsymu 175 10 by by IN cord-006252-cbelsymu 175 11 the the DT cord-006252-cbelsymu 175 12 terms term NNS cord-006252-cbelsymu 175 13 antigenic antigenic JJ cord-006252-cbelsymu 175 14 drift drift NN cord-006252-cbelsymu 175 15 and and CC cord-006252-cbelsymu 175 16 antigenic antigenic JJ cord-006252-cbelsymu 175 17 shift shift NN cord-006252-cbelsymu 175 18 . . . cord-006252-cbelsymu 176 1 Antigenic antigenic JJ cord-006252-cbelsymu 176 2 drift drift NN cord-006252-cbelsymu 176 3 is be VBZ cord-006252-cbelsymu 176 4 a a DT cord-006252-cbelsymu 176 5 minor minor JJ cord-006252-cbelsymu 176 6 change change NN cord-006252-cbelsymu 176 7 that that WDT cord-006252-cbelsymu 176 8 occurs occur VBZ cord-006252-cbelsymu 176 9 . . . cord-006252-cbelsymu 177 1 Minor minor JJ cord-006252-cbelsymu 177 2 changes change NNS cord-006252-cbelsymu 177 3 also also RB cord-006252-cbelsymu 177 4 occur occur VBP cord-006252-cbelsymu 177 5 when when WRB cord-006252-cbelsymu 177 6 antigens antigen NNS cord-006252-cbelsymu 177 7 are be VBP cord-006252-cbelsymu 177 8 glycosylated glycosylate VBN cord-006252-cbelsymu 177 9 and and CC cord-006252-cbelsymu 177 10 camouflage camouflage VB cord-006252-cbelsymu 177 11 the the DT cord-006252-cbelsymu 177 12 previously previously RB cord-006252-cbelsymu 177 13 exposed expose VBN cord-006252-cbelsymu 177 14 antigenic antigenic JJ cord-006252-cbelsymu 177 15 site site NN cord-006252-cbelsymu 177 16 . . . cord-006252-cbelsymu 178 1 Antigenic antigenic JJ cord-006252-cbelsymu 178 2 shift shift NN cord-006252-cbelsymu 178 3 is be VBZ cord-006252-cbelsymu 178 4 a a DT cord-006252-cbelsymu 178 5 major major JJ cord-006252-cbelsymu 178 6 change change NN cord-006252-cbelsymu 178 7 that that WDT cord-006252-cbelsymu 178 8 occurs occur VBZ cord-006252-cbelsymu 178 9 by by IN cord-006252-cbelsymu 178 10 gene gene NN cord-006252-cbelsymu 178 11 reassortment reassortment NN cord-006252-cbelsymu 178 12 resulting result VBG cord-006252-cbelsymu 178 13 in in IN cord-006252-cbelsymu 178 14 a a DT cord-006252-cbelsymu 178 15 new new JJ cord-006252-cbelsymu 178 16 subtype subtype NN cord-006252-cbelsymu 178 17 . . . cord-006252-cbelsymu 179 1 The the DT cord-006252-cbelsymu 179 2 change change NN cord-006252-cbelsymu 179 3 from from IN cord-006252-cbelsymu 179 4 the the DT cord-006252-cbelsymu 179 5 influenza influenza NN cord-006252-cbelsymu 179 6 A a NN cord-006252-cbelsymu 179 7 ( ( -LRB- cord-006252-cbelsymu 179 8 H2N2 H2N2 NNP cord-006252-cbelsymu 179 9 ) ) -RRB- cord-006252-cbelsymu 179 10 to to IN cord-006252-cbelsymu 179 11 the the DT cord-006252-cbelsymu 179 12 influenza influenza NN cord-006252-cbelsymu 179 13 A a NN cord-006252-cbelsymu 179 14 ( ( -LRB- cord-006252-cbelsymu 179 15 H3N2 H3N2 NNP cord-006252-cbelsymu 179 16 ) ) -RRB- cord-006252-cbelsymu 179 17 subtype subtype NN cord-006252-cbelsymu 179 18 that that WDT cord-006252-cbelsymu 179 19 occurred occur VBD cord-006252-cbelsymu 179 20 in in IN cord-006252-cbelsymu 179 21 1968 1968 CD cord-006252-cbelsymu 179 22 is be VBZ cord-006252-cbelsymu 179 23 such such PDT cord-006252-cbelsymu 179 24 an an DT cord-006252-cbelsymu 179 25 example example NN cord-006252-cbelsymu 179 26 . . . cord-006252-cbelsymu 180 1 Gene gene NN cord-006252-cbelsymu 180 2 reassortment reassortment NN cord-006252-cbelsymu 180 3 probably probably RB cord-006252-cbelsymu 180 4 occurs occur VBZ cord-006252-cbelsymu 180 5 when when WRB cord-006252-cbelsymu 180 6 2 2 CD cord-006252-cbelsymu 180 7 different different JJ cord-006252-cbelsymu 180 8 subtypes subtype NNS cord-006252-cbelsymu 180 9 coinfect coinfect VBP cord-006252-cbelsymu 180 10 the the DT cord-006252-cbelsymu 180 11 same same JJ cord-006252-cbelsymu 180 12 host host NN cord-006252-cbelsymu 180 13 . . . cord-006252-cbelsymu 181 1 Serum serum NN cord-006252-cbelsymu 181 2 antibody antibody NN cord-006252-cbelsymu 181 3 to to IN cord-006252-cbelsymu 181 4 the the DT cord-006252-cbelsymu 181 5 surface surface NN cord-006252-cbelsymu 181 6 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 181 7 and and CC cord-006252-cbelsymu 182 1 neuraminidase neuraminidase NN cord-006252-cbelsymu 182 2 proteins protein NNS cord-006252-cbelsymu 182 3 is be VBZ cord-006252-cbelsymu 182 4 important important JJ cord-006252-cbelsymu 182 5 in in IN cord-006252-cbelsymu 182 6 protection protection NN cord-006252-cbelsymu 182 7 against against IN cord-006252-cbelsymu 182 8 infection infection NN cord-006252-cbelsymu 182 9 and and CC cord-006252-cbelsymu 182 10 the the DT cord-006252-cbelsymu 182 11 development development NN cord-006252-cbelsymu 182 12 of of IN cord-006252-cbelsymu 182 13 disease disease NN cord-006252-cbelsymu 182 14 . . . cord-006252-cbelsymu 183 1 Humoral Humoral NNP cord-006252-cbelsymu 183 2 antibody antibody NN cord-006252-cbelsymu 183 3 to to IN cord-006252-cbelsymu 183 4 the the DT cord-006252-cbelsymu 183 5 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 183 6 component component NN cord-006252-cbelsymu 183 7 is be VBZ cord-006252-cbelsymu 183 8 the the DT cord-006252-cbelsymu 183 9 most most RBS cord-006252-cbelsymu 183 10 critical critical JJ cord-006252-cbelsymu 183 11 , , , cord-006252-cbelsymu 183 12 but but CC cord-006252-cbelsymu 183 13 the the DT cord-006252-cbelsymu 183 14 importance importance NN cord-006252-cbelsymu 183 15 of of IN cord-006252-cbelsymu 183 16 cell cell NN cord-006252-cbelsymu 183 17 - - HYPH cord-006252-cbelsymu 183 18 mediated mediate VBN cord-006252-cbelsymu 183 19 immunity immunity NN cord-006252-cbelsymu 183 20 is be VBZ cord-006252-cbelsymu 183 21 less less RBR cord-006252-cbelsymu 183 22 clear clear JJ cord-006252-cbelsymu 183 23 . . . cord-006252-cbelsymu 184 1 The the DT cord-006252-cbelsymu 184 2 humoral humoral JJ cord-006252-cbelsymu 184 3 immune immune JJ cord-006252-cbelsymu 184 4 response response NN cord-006252-cbelsymu 184 5 is be VBZ cord-006252-cbelsymu 184 6 highly highly RB cord-006252-cbelsymu 184 7 specific specific JJ cord-006252-cbelsymu 184 8 for for IN cord-006252-cbelsymu 184 9 certain certain JJ cord-006252-cbelsymu 184 10 epitopes epitope NNS cord-006252-cbelsymu 184 11 on on IN cord-006252-cbelsymu 184 12 the the DT cord-006252-cbelsymu 184 13 surface surface NN cord-006252-cbelsymu 184 14 of of IN cord-006252-cbelsymu 184 15 the the DT cord-006252-cbelsymu 184 16 virus virus NN cord-006252-cbelsymu 184 17 . . . cord-006252-cbelsymu 185 1 The the DT cord-006252-cbelsymu 185 2 cellular cellular JJ cord-006252-cbelsymu 185 3 response response NN cord-006252-cbelsymu 185 4 , , , cord-006252-cbelsymu 185 5 in in IN cord-006252-cbelsymu 185 6 contrast contrast NN cord-006252-cbelsymu 185 7 , , , cord-006252-cbelsymu 185 8 is be VBZ cord-006252-cbelsymu 185 9 less less RBR cord-006252-cbelsymu 185 10 specific specific JJ cord-006252-cbelsymu 185 11 and and CC cord-006252-cbelsymu 185 12 more more RBR cord-006252-cbelsymu 185 13 cross cross JJ cord-006252-cbelsymu 185 14 - - JJ cord-006252-cbelsymu 185 15 reactive reactive JJ cord-006252-cbelsymu 185 16 . . . cord-006252-cbelsymu 186 1 The the DT cord-006252-cbelsymu 186 2 B b NN cord-006252-cbelsymu 186 3 cells cell NNS cord-006252-cbelsymu 186 4 which which WDT cord-006252-cbelsymu 186 5 produce produce VBP cord-006252-cbelsymu 186 6 humoral humoral JJ cord-006252-cbelsymu 186 7 antibody antibody NN cord-006252-cbelsymu 186 8 recognise recognise VB cord-006252-cbelsymu 186 9 antigenic antigenic JJ cord-006252-cbelsymu 186 10 determinants determinant NNS cord-006252-cbelsymu 186 11 , , , cord-006252-cbelsymu 186 12 or or CC cord-006252-cbelsymu 186 13 epitopes epitope NNS cord-006252-cbelsymu 186 14 , , , cord-006252-cbelsymu 186 15 adjacent adjacent JJ cord-006252-cbelsymu 186 16 in in IN cord-006252-cbelsymu 186 17 space space NN cord-006252-cbelsymu 186 18 but but CC cord-006252-cbelsymu 186 19 not not RB cord-006252-cbelsymu 186 20 in in IN cord-006252-cbelsymu 186 21 sequence sequence NN cord-006252-cbelsymu 186 22 , , , cord-006252-cbelsymu 186 23 while while IN cord-006252-cbelsymu 186 24 T t NN cord-006252-cbelsymu 186 25 cells cell NNS cord-006252-cbelsymu 186 26 recognise recognise VBP cord-006252-cbelsymu 186 27 epitopes epitope NNS cord-006252-cbelsymu 186 28 adjacent adjacent JJ cord-006252-cbelsymu 186 29 in in IN cord-006252-cbelsymu 186 30 sequence sequence NN cord-006252-cbelsymu 186 31 but but CC cord-006252-cbelsymu 186 32 not not RB cord-006252-cbelsymu 186 33 necessarily necessarily RB cord-006252-cbelsymu 186 34 in in IN cord-006252-cbelsymu 186 35 space space NN cord-006252-cbelsymu 186 36 . . . cord-006252-cbelsymu 187 1 The the DT cord-006252-cbelsymu 187 2 implication implication NN cord-006252-cbelsymu 187 3 here here RB cord-006252-cbelsymu 187 4 is be VBZ cord-006252-cbelsymu 187 5 that that DT cord-006252-cbelsymu 187 6 B b NN cord-006252-cbelsymu 187 7 cell cell NN cord-006252-cbelsymu 187 8 epitopes epitope NNS cord-006252-cbelsymu 187 9 are be VBP cord-006252-cbelsymu 187 10 intact intact JJ cord-006252-cbelsymu 187 11 external external JJ cord-006252-cbelsymu 187 12 molecules molecule NNS cord-006252-cbelsymu 187 13 such such JJ cord-006252-cbelsymu 187 14 as as IN cord-006252-cbelsymu 187 15 haemagglutinins haemagglutinins NNP cord-006252-cbelsymu 187 16 , , , cord-006252-cbelsymu 187 17 while while IN cord-006252-cbelsymu 187 18 T T NNP cord-006252-cbelsymu 187 19 cell cell NN cord-006252-cbelsymu 187 20 epitopes epitope NNS cord-006252-cbelsymu 187 21 appear appear VBP cord-006252-cbelsymu 187 22 to to TO cord-006252-cbelsymu 187 23 be be VB cord-006252-cbelsymu 187 24 linear linear JJ cord-006252-cbelsymu 187 25 sequences sequence NNS cord-006252-cbelsymu 187 26 exposed expose VBN cord-006252-cbelsymu 187 27 by by IN cord-006252-cbelsymu 187 28 enzymatic enzymatic JJ cord-006252-cbelsymu 187 29 breakdown breakdown NN cord-006252-cbelsymu 187 30 of of IN cord-006252-cbelsymu 187 31 the the DT cord-006252-cbelsymu 187 32 original original JJ cord-006252-cbelsymu 187 33 molecule molecule NN cord-006252-cbelsymu 187 34 . . . cord-006252-cbelsymu 188 1 A a DT cord-006252-cbelsymu 188 2 killed kill VBN cord-006252-cbelsymu 188 3 ( ( -LRB- cord-006252-cbelsymu 188 4 inactivated inactivate VBN cord-006252-cbelsymu 188 5 ) ) -RRB- cord-006252-cbelsymu 188 6 vaccine vaccine NN cord-006252-cbelsymu 188 7 against against IN cord-006252-cbelsymu 188 8 influenza influenza NN cord-006252-cbelsymu 188 9 virus virus NN cord-006252-cbelsymu 188 10 was be VBD cord-006252-cbelsymu 188 11 first first RB cord-006252-cbelsymu 188 12 developed develop VBN cord-006252-cbelsymu 188 13 in in IN cord-006252-cbelsymu 188 14 the the DT cord-006252-cbelsymu 188 15 1940s 1940 NNS cord-006252-cbelsymu 188 16 . . . cord-006252-cbelsymu 189 1 Since since IN cord-006252-cbelsymu 189 2 then then RB cord-006252-cbelsymu 189 3 the the DT cord-006252-cbelsymu 189 4 manufacturing manufacturing NN cord-006252-cbelsymu 189 5 process process NN cord-006252-cbelsymu 189 6 has have VBZ cord-006252-cbelsymu 189 7 resulted result VBN cord-006252-cbelsymu 189 8 in in IN cord-006252-cbelsymu 189 9 a a DT cord-006252-cbelsymu 189 10 more more RBR cord-006252-cbelsymu 189 11 pure pure JJ cord-006252-cbelsymu 189 12 vaccine vaccine NN cord-006252-cbelsymu 189 13 . . . cord-006252-cbelsymu 190 1 The the DT cord-006252-cbelsymu 190 2 virus virus NN cord-006252-cbelsymu 190 3 is be VBZ cord-006252-cbelsymu 190 4 grown grow VBN cord-006252-cbelsymu 190 5 in in IN cord-006252-cbelsymu 190 6 embryonated embryonate VBN cord-006252-cbelsymu 190 7 eggs egg NNS cord-006252-cbelsymu 190 8 . . . cord-006252-cbelsymu 191 1 Most Most JJS cord-006252-cbelsymu 191 2 of of IN cord-006252-cbelsymu 191 3 the the DT cord-006252-cbelsymu 191 4 egg egg NN cord-006252-cbelsymu 191 5 protein protein NN cord-006252-cbelsymu 191 6 is be VBZ cord-006252-cbelsymu 191 7 now now RB cord-006252-cbelsymu 191 8 eliminated eliminate VBN cord-006252-cbelsymu 191 9 and and CC cord-006252-cbelsymu 191 10 the the DT cord-006252-cbelsymu 191 11 side side NN cord-006252-cbelsymu 191 12 effects effect NNS cord-006252-cbelsymu 191 13 have have VBP cord-006252-cbelsymu 191 14 been be VBN cord-006252-cbelsymu 191 15 reduced reduce VBN cord-006252-cbelsymu 191 16 markedly markedly RB cord-006252-cbelsymu 191 17 . . . cord-006252-cbelsymu 192 1 Killed kill VBN cord-006252-cbelsymu 192 2 vaccines vaccine NNS cord-006252-cbelsymu 192 3 are be VBP cord-006252-cbelsymu 192 4 referred refer VBN cord-006252-cbelsymu 192 5 to to IN cord-006252-cbelsymu 192 6 as as IN cord-006252-cbelsymu 192 7 either either CC cord-006252-cbelsymu 192 8 whole whole JJ cord-006252-cbelsymu 192 9 virus virus NN cord-006252-cbelsymu 192 10 or or CC cord-006252-cbelsymu 192 11 split split NN cord-006252-cbelsymu 192 12 virus virus NN cord-006252-cbelsymu 192 13 : : : cord-006252-cbelsymu 193 1 whole whole JJ cord-006252-cbelsymu 193 2 virus virus NN cord-006252-cbelsymu 193 3 vaccines vaccine NNS cord-006252-cbelsymu 193 4 are be VBP cord-006252-cbelsymu 193 5 inactivated inactivate VBN cord-006252-cbelsymu 193 6 by by IN cord-006252-cbelsymu 193 7 formalin formalin NN cord-006252-cbelsymu 193 8 ; ; : cord-006252-cbelsymu 193 9 split split NN cord-006252-cbelsymu 193 10 or or CC cord-006252-cbelsymu 193 11 subunit subunit NN cord-006252-cbelsymu 193 12 vaccines vaccine NNS cord-006252-cbelsymu 193 13 use use VBP cord-006252-cbelsymu 193 14 whole whole JJ cord-006252-cbelsymu 193 15 virus virus NN cord-006252-cbelsymu 193 16 which which WDT cord-006252-cbelsymu 193 17 is be VBZ cord-006252-cbelsymu 193 18 treated treat VBN cord-006252-cbelsymu 193 19 with with IN cord-006252-cbelsymu 193 20 a a DT cord-006252-cbelsymu 193 21 detergent detergent NN cord-006252-cbelsymu 193 22 to to TO cord-006252-cbelsymu 193 23 free free VB cord-006252-cbelsymu 193 24 up up RP cord-006252-cbelsymu 193 25 the the DT cord-006252-cbelsymu 193 26 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 193 27 and and CC cord-006252-cbelsymu 193 28 neuraminidase neuraminidase NN cord-006252-cbelsymu 193 29 subunits subunit NNS cord-006252-cbelsymu 193 30 from from IN cord-006252-cbelsymu 193 31 the the DT cord-006252-cbelsymu 193 32 viral viral JJ cord-006252-cbelsymu 193 33 surface surface NN cord-006252-cbelsymu 193 34 , , , cord-006252-cbelsymu 193 35 then then RB cord-006252-cbelsymu 193 36 formalin formalin NN cord-006252-cbelsymu 193 37 is be VBZ cord-006252-cbelsymu 193 38 added add VBN cord-006252-cbelsymu 193 39 . . . cord-006252-cbelsymu 194 1 In in IN cord-006252-cbelsymu 194 2 children child NNS cord-006252-cbelsymu 194 3 who who WP cord-006252-cbelsymu 194 4 have have VBP cord-006252-cbelsymu 194 5 not not RB cord-006252-cbelsymu 194 6 previously previously RB cord-006252-cbelsymu 194 7 been be VBN cord-006252-cbelsymu 194 8 vaccinated vaccinate VBN cord-006252-cbelsymu 194 9 , , , cord-006252-cbelsymu 194 10 split split VBN cord-006252-cbelsymu 194 11 virus virus NN cord-006252-cbelsymu 194 12 vaccines vaccine NNS cord-006252-cbelsymu 194 13 cause cause VBP cord-006252-cbelsymu 194 14 fewer few JJR cord-006252-cbelsymu 194 15 side side NN cord-006252-cbelsymu 194 16 effects effect NNS cord-006252-cbelsymu 194 17 such such JJ cord-006252-cbelsymu 194 18 as as IN cord-006252-cbelsymu 194 19 fever fever NN cord-006252-cbelsymu 194 20 and and CC cord-006252-cbelsymu 194 21 myalgias myalgia NNS cord-006252-cbelsymu 194 22 than than IN cord-006252-cbelsymu 194 23 whole whole JJ cord-006252-cbelsymu 194 24 virus virus NN cord-006252-cbelsymu 194 25 vaccines vaccine NNS cord-006252-cbelsymu 194 26 . . . cord-006252-cbelsymu 195 1 Live live JJ cord-006252-cbelsymu 195 2 attenuated attenuated JJ cord-006252-cbelsymu 195 3 vaccines vaccine NNS cord-006252-cbelsymu 195 4 have have VBP cord-006252-cbelsymu 195 5 been be VBN cord-006252-cbelsymu 195 6 in in IN cord-006252-cbelsymu 195 7 the the DT cord-006252-cbelsymu 195 8 development development NN cord-006252-cbelsymu 195 9 stages stage NNS cord-006252-cbelsymu 195 10 for for IN cord-006252-cbelsymu 195 11 over over IN cord-006252-cbelsymu 195 12 10 10 CD cord-006252-cbelsymu 195 13 years year NNS cord-006252-cbelsymu 195 14 and and CC cord-006252-cbelsymu 195 15 are be VBP cord-006252-cbelsymu 195 16 currently currently RB cord-006252-cbelsymu 195 17 being be VBG cord-006252-cbelsymu 195 18 tested test VBN cord-006252-cbelsymu 195 19 ; ; : cord-006252-cbelsymu 195 20 they -PRON- PRP cord-006252-cbelsymu 195 21 are be VBP cord-006252-cbelsymu 195 22 not not RB cord-006252-cbelsymu 195 23 commercially commercially RB cord-006252-cbelsymu 195 24 available available JJ cord-006252-cbelsymu 195 25 . . . cord-006252-cbelsymu 196 1 A a DT cord-006252-cbelsymu 196 2 genetically genetically RB cord-006252-cbelsymu 196 3 stable stable JJ cord-006252-cbelsymu 196 4 method method NN cord-006252-cbelsymu 196 5 of of IN cord-006252-cbelsymu 196 6 production production NN cord-006252-cbelsymu 196 7 was be VBD cord-006252-cbelsymu 196 8 the the DT cord-006252-cbelsymu 196 9 initial initial JJ cord-006252-cbelsymu 196 10 problem problem NN cord-006252-cbelsymu 196 11 but but CC cord-006252-cbelsymu 196 12 this this DT cord-006252-cbelsymu 196 13 has have VBZ cord-006252-cbelsymu 196 14 since since IN cord-006252-cbelsymu 196 15 been be VBN cord-006252-cbelsymu 196 16 solved solve VBN cord-006252-cbelsymu 196 17 . . . cord-006252-cbelsymu 197 1 However however RB cord-006252-cbelsymu 197 2 , , , cord-006252-cbelsymu 197 3 it -PRON- PRP cord-006252-cbelsymu 197 4 has have VBZ cord-006252-cbelsymu 197 5 been be VBN cord-006252-cbelsymu 197 6 difficult difficult JJ cord-006252-cbelsymu 197 7 to to TO cord-006252-cbelsymu 197 8 show show VB cord-006252-cbelsymu 197 9 a a DT cord-006252-cbelsymu 197 10 clear clear JJ cord-006252-cbelsymu 197 11 advantage advantage NN cord-006252-cbelsymu 197 12 of of IN cord-006252-cbelsymu 197 13 live live NN cord-006252-cbelsymu 197 14 over over IN cord-006252-cbelsymu 197 15 killed kill VBN cord-006252-cbelsymu 197 16 vaccines vaccine NNS cord-006252-cbelsymu 197 17 . . . cord-006252-cbelsymu 198 1 The the DT cord-006252-cbelsymu 198 2 currently currently RB cord-006252-cbelsymu 198 3 licensed license VBN cord-006252-cbelsymu 198 4 influenza influenza NN cord-006252-cbelsymu 198 5 vaccine vaccine NN cord-006252-cbelsymu 198 6 contains contain VBZ cord-006252-cbelsymu 198 7 3 3 CD cord-006252-cbelsymu 198 8 strains strain NNS cord-006252-cbelsymu 198 9 : : : cord-006252-cbelsymu 198 10 influenza influenza NNP cord-006252-cbelsymu 198 11 A A NNP cord-006252-cbelsymu 198 12 / / SYM cord-006252-cbelsymu 198 13 Shanghai Shanghai NNP cord-006252-cbelsymu 198 14 / / SYM cord-006252-cbelsymu 198 15 I -PRON- PRP cord-006252-cbelsymu 198 16 6/89 6/89 CD cord-006252-cbelsymu 198 17 ( ( -LRB- cord-006252-cbelsymu 198 18 H3N2 H3N2 NNP cord-006252-cbelsymu 198 19 ) ) -RRB- cord-006252-cbelsymu 198 20 ; ; : cord-006252-cbelsymu 198 21 influenza influenza NN cord-006252-cbelsymu 198 22 A A NNP cord-006252-cbelsymu 198 23 / / SYM cord-006252-cbelsymu 198 24 Taiwan Taiwan NNP cord-006252-cbelsymu 198 25 / / , cord-006252-cbelsymu 198 26 I/86 i/86 NN cord-006252-cbelsymu 198 27 ( ( -LRB- cord-006252-cbelsymu 198 28 HINl HINl NNP cord-006252-cbelsymu 198 29 ) ) -RRB- cord-006252-cbelsymu 198 30 ; ; : cord-006252-cbelsymu 198 31 and and CC cord-006252-cbelsymu 199 1 influenza influenza NN cord-006252-cbelsymu 199 2 B/ B/ NNP cord-006252-cbelsymu 199 3 Yamagata Yamagata NNP cord-006252-cbelsymu 199 4 / / SYM cord-006252-cbelsymu 199 5 I I NNP cord-006252-cbelsymu 199 6 6/88 6/88 CD cord-006252-cbelsymu 199 7 . . . cord-006252-cbelsymu 200 1 There there EX cord-006252-cbelsymu 200 2 are be VBP cord-006252-cbelsymu 200 3 15ILg 15ilg CD cord-006252-cbelsymu 200 4 of of IN cord-006252-cbelsymu 200 5 haemagglutinin haemagglutinin NN cord-006252-cbelsymu 200 6 for for IN cord-006252-cbelsymu 200 7 each each DT cord-006252-cbelsymu 200 8 strain strain NN cord-006252-cbelsymu 200 9 in in IN cord-006252-cbelsymu 200 10 the the DT cord-006252-cbelsymu 200 11 vaccine vaccine NN cord-006252-cbelsymu 200 12 . . . cord-006252-cbelsymu 201 1 It -PRON- PRP cord-006252-cbelsymu 201 2 should should MD cord-006252-cbelsymu 201 3 be be VB cord-006252-cbelsymu 201 4 given give VBN cord-006252-cbelsymu 201 5 intramuscularly intramuscularly RB cord-006252-cbelsymu 201 6 in in IN cord-006252-cbelsymu 201 7 the the DT cord-006252-cbelsymu 201 8 deltoid deltoid NN cord-006252-cbelsymu 201 9 in in IN cord-006252-cbelsymu 201 10 adults adult NNS cord-006252-cbelsymu 201 11 and and CC cord-006252-cbelsymu 201 12 in in IN cord-006252-cbelsymu 201 13 the the DT cord-006252-cbelsymu 201 14 anterolateral anterolateral JJ cord-006252-cbelsymu 201 15 thigh thigh NN cord-006252-cbelsymu 201 16 in in IN cord-006252-cbelsymu 201 17 infants infant NNS cord-006252-cbelsymu 201 18 and and CC cord-006252-cbelsymu 201 19 young young JJ cord-006252-cbelsymu 201 20 children child NNS cord-006252-cbelsymu 201 21 . . . cord-006252-cbelsymu 202 1 Administration administration NN cord-006252-cbelsymu 202 2 in in IN cord-006252-cbelsymu 202 3 the the DT cord-006252-cbelsymu 202 4 buttock buttock NN cord-006252-cbelsymu 202 5 is be VBZ cord-006252-cbelsymu 202 6 not not RB cord-006252-cbelsymu 202 7 recommended recommend VBN cord-006252-cbelsymu 202 8 because because IN cord-006252-cbelsymu 202 9 it -PRON- PRP cord-006252-cbelsymu 202 10 may may MD cord-006252-cbelsymu 202 11 result result VB cord-006252-cbelsymu 202 12 in in IN cord-006252-cbelsymu 202 13 a a DT cord-006252-cbelsymu 202 14 poorer poor JJR cord-006252-cbelsymu 202 15 immune immune JJ cord-006252-cbelsymu 202 16 response response NN cord-006252-cbelsymu 202 17 due due IN cord-006252-cbelsymu 202 18 to to IN cord-006252-cbelsymu 202 19 inadequate inadequate JJ cord-006252-cbelsymu 202 20 absorption absorption NN cord-006252-cbelsymu 202 21 from from IN cord-006252-cbelsymu 202 22 the the DT cord-006252-cbelsymu 202 23 subcutaneous subcutaneous JJ cord-006252-cbelsymu 202 24 fat fat NN cord-006252-cbelsymu 202 25 . . . cord-006252-cbelsymu 203 1 The the DT cord-006252-cbelsymu 203 2 strains strain NNS cord-006252-cbelsymu 203 3 to to TO cord-006252-cbelsymu 203 4 be be VB cord-006252-cbelsymu 203 5 included include VBN cord-006252-cbelsymu 203 6 in in IN cord-006252-cbelsymu 203 7 the the DT cord-006252-cbelsymu 203 8 vaccine vaccine NN cord-006252-cbelsymu 203 9 change change NN cord-006252-cbelsymu 203 10 from from IN cord-006252-cbelsymu 203 11 year year NN cord-006252-cbelsymu 203 12 to to IN cord-006252-cbelsymu 203 13 year year NN cord-006252-cbelsymu 203 14 according accord VBG cord-006252-cbelsymu 203 15 to to IN cord-006252-cbelsymu 203 16 World World NNP cord-006252-cbelsymu 203 17 Health Health NNP cord-006252-cbelsymu 203 18 Organization Organization NNP cord-006252-cbelsymu 203 19 ( ( -LRB- cord-006252-cbelsymu 203 20 WHO who WP cord-006252-cbelsymu 203 21 ) ) -RRB- cord-006252-cbelsymu 203 22 recommendations recommendation NNS cord-006252-cbelsymu 203 23 . . . cord-006252-cbelsymu 204 1 435 435 CD cord-006252-cbelsymu 204 2 _SP cord-006252-cbelsymu 205 1 The the DT cord-006252-cbelsymu 205 2 primary primary JJ cord-006252-cbelsymu 205 3 target target NN cord-006252-cbelsymu 205 4 groups group NNS cord-006252-cbelsymu 205 5 are be VBP cord-006252-cbelsymu 205 6 as as IN cord-006252-cbelsymu 205 7 follows follow VBZ cord-006252-cbelsymu 206 1 ( ( -LRB- cord-006252-cbelsymu 206 2 Recommendations Recommendations NNPS cord-006252-cbelsymu 206 3 of of IN cord-006252-cbelsymu 206 4 the the DT cord-006252-cbelsymu 206 5 Immunization Immunization NNP cord-006252-cbelsymu 206 6 Practices Practices NNPS cord-006252-cbelsymu 206 7 Advisory Advisory NNP cord-006252-cbelsymu 206 8 Committee Committee NNP cord-006252-cbelsymu 206 9 1990 1990 CD cord-006252-cbelsymu 206 10 ) ) -RRB- cord-006252-cbelsymu 206 11 . . . cord-006252-cbelsymu 207 1 I. I. NNP cord-006252-cbelsymu 207 2 Persons person NNS cord-006252-cbelsymu 207 3 aged age VBN cord-006252-cbelsymu 207 4 65 65 CD cord-006252-cbelsymu 207 5 years year NNS cord-006252-cbelsymu 207 6 or or CC cord-006252-cbelsymu 207 7 older old JJR cord-006252-cbelsymu 207 8 . . . cord-006252-cbelsymu 208 1 2 2 LS cord-006252-cbelsymu 208 2 . . . cord-006252-cbelsymu 209 1 Residents resident NNS cord-006252-cbelsymu 209 2 of of IN cord-006252-cbelsymu 209 3 nursing nursing NN cord-006252-cbelsymu 209 4 homes home NNS cord-006252-cbelsymu 209 5 and and CC cord-006252-cbelsymu 209 6 other other JJ cord-006252-cbelsymu 209 7 chronic chronic NN cord-006252-cbelsymu 209 8 - - HYPH cord-006252-cbelsymu 209 9 care care NN cord-006252-cbelsymu 209 10 facilities facility NNS cord-006252-cbelsymu 209 11 housing housing NN cord-006252-cbelsymu 209 12 persons person NNS cord-006252-cbelsymu 209 13 of of IN cord-006252-cbelsymu 209 14 any any DT cord-006252-cbelsymu 209 15 age age NN cord-006252-cbelsymu 209 16 with with IN cord-006252-cbelsymu 209 17 chronic chronic JJ cord-006252-cbelsymu 209 18 medical medical JJ cord-006252-cbelsymu 209 19 conditions condition NNS cord-006252-cbelsymu 209 20 . . . cord-006252-cbelsymu 210 1 of of IN cord-006252-cbelsymu 210 2 the the DT cord-006252-cbelsymu 210 3 pulmonary pulmonary JJ cord-006252-cbelsymu 210 4 or or CC cord-006252-cbelsymu 210 5 cardiovascular cardiovascular JJ cord-006252-cbelsymu 210 6 systems system NNS cord-006252-cbelsymu 210 7 , , , cord-006252-cbelsymu 210 8 including include VBG cord-006252-cbelsymu 210 9 children child NNS cord-006252-cbelsymu 210 10 with with IN cord-006252-cbelsymu 210 11 asthma asthma NN cord-006252-cbelsymu 210 12 . . . cord-006252-cbelsymu 211 1 4 4 LS cord-006252-cbelsymu 211 2 . . . cord-006252-cbelsymu 212 1 Adults adult NNS cord-006252-cbelsymu 212 2 and and CC cord-006252-cbelsymu 212 3 children child NNS cord-006252-cbelsymu 212 4 who who WP cord-006252-cbelsymu 212 5 have have VBP cord-006252-cbelsymu 212 6 required require VBN cord-006252-cbelsymu 212 7 regular regular JJ cord-006252-cbelsymu 212 8 medical medical JJ cord-006252-cbelsymu 212 9 follow follow NN cord-006252-cbelsymu 212 10 - - HYPH cord-006252-cbelsymu 212 11 up up NN cord-006252-cbelsymu 212 12 or or CC cord-006252-cbelsymu 212 13 hospitalisation hospitalisation NN cord-006252-cbelsymu 212 14 during during IN cord-006252-cbelsymu 212 15 the the DT cord-006252-cbelsymu 212 16 preceding precede VBG cord-006252-cbelsymu 212 17 year year NN cord-006252-cbelsymu 212 18 because because IN cord-006252-cbelsymu 212 19 of of IN cord-006252-cbelsymu 212 20 chronic chronic JJ cord-006252-cbelsymu 212 21 metabolic metabolic JJ cord-006252-cbelsymu 212 22 diseases disease NNS cord-006252-cbelsymu 212 23 ( ( -LRB- cord-006252-cbelsymu 212 24 including include VBG cord-006252-cbelsymu 212 25 diabetes diabetes NN cord-006252-cbelsymu 212 26 mellitus mellitus NN cord-006252-cbelsymu 212 27 ) ) -RRB- cord-006252-cbelsymu 212 28 , , , cord-006252-cbelsymu 212 29 renal renal JJ cord-006252-cbelsymu 212 30 dysfunction dysfunction NN cord-006252-cbelsymu 212 31 , , , cord-006252-cbelsymu 212 32 haemoglobinopathies haemoglobinopathy NNS cord-006252-cbelsymu 212 33 , , , cord-006252-cbelsymu 212 34 or or CC cord-006252-cbelsymu 212 35 immunosuppression immunosuppression NN cord-006252-cbelsymu 212 36 ( ( -LRB- cord-006252-cbelsymu 212 37 including include VBG cord-006252-cbelsymu 212 38 immunosuppression immunosuppression NN cord-006252-cbelsymu 212 39 caused cause VBN cord-006252-cbelsymu 212 40 by by IN cord-006252-cbelsymu 212 41 medications medication NNS cord-006252-cbelsymu 212 42 ) ) -RRB- cord-006252-cbelsymu 212 43 . . . cord-006252-cbelsymu 213 1 I. I. NNP cord-006252-cbelsymu 213 2 Physicians Physicians NNP cord-006252-cbelsymu 213 3 , , , cord-006252-cbelsymu 213 4 nurses nurse NNS cord-006252-cbelsymu 213 5 and and CC cord-006252-cbelsymu 213 6 other other JJ cord-006252-cbelsymu 213 7 personnel personnel NNS cord-006252-cbelsymu 213 8 in in IN cord-006252-cbelsymu 213 9 both both DT cord-006252-cbelsymu 213 10 hospital hospital NN cord-006252-cbelsymu 213 11 and and CC cord-006252-cbelsymu 213 12 outpatient outpatient NN cord-006252-cbelsymu 213 13 - - HYPH cord-006252-cbelsymu 213 14 care care NN cord-006252-cbelsymu 213 15 settings setting NNS cord-006252-cbelsymu 213 16 who who WP cord-006252-cbelsymu 213 17 have have VBP cord-006252-cbelsymu 213 18 contact contact NN cord-006252-cbelsymu 213 19 with with IN cord-006252-cbelsymu 213 20 high high JJ cord-006252-cbelsymu 213 21 - - HYPH cord-006252-cbelsymu 213 22 risk risk NN cord-006252-cbelsymu 213 23 persons person NNS cord-006252-cbelsymu 213 24 in in IN cord-006252-cbelsymu 213 25 all all DT cord-006252-cbelsymu 213 26 age age NN cord-006252-cbelsymu 213 27 groups group NNS cord-006252-cbelsymu 213 28 , , , cord-006252-cbelsymu 213 29 including include VBG cord-006252-cbelsymu 213 30 infants infant NNS cord-006252-cbelsymu 213 31 . . . cord-006252-cbelsymu 214 1 2 2 LS cord-006252-cbelsymu 214 2 . . . cord-006252-cbelsymu 215 1 Employees employee NNS cord-006252-cbelsymu 215 2 of of IN cord-006252-cbelsymu 215 3 nursing nursing NN cord-006252-cbelsymu 215 4 homes home NNS cord-006252-cbelsymu 215 5 and and CC cord-006252-cbelsymu 215 6 chronic chronic JJ cord-006252-cbelsymu 215 7 - - HYPH cord-006252-cbelsymu 215 8 care care NN cord-006252-cbelsymu 215 9 facilities facility NNS cord-006252-cbelsymu 215 10 who who WP cord-006252-cbelsymu 215 11 have have VBP cord-006252-cbelsymu 215 12 contact contact NN cord-006252-cbelsymu 215 13 with with IN cord-006252-cbelsymu 215 14 patients patient NNS cord-006252-cbelsymu 215 15 or or CC cord-006252-cbelsymu 215 16 residents resident NNS cord-006252-cbelsymu 215 17 . . . cord-006252-cbelsymu 216 1 3 3 LS cord-006252-cbelsymu 216 2 . . . cord-006252-cbelsymu 217 1 Providers provider NNS cord-006252-cbelsymu 217 2 of of IN cord-006252-cbelsymu 217 3 home home NN cord-006252-cbelsymu 217 4 care care NN cord-006252-cbelsymu 217 5 to to IN cord-006252-cbelsymu 217 6 high high JJ cord-006252-cbelsymu 217 7 risk risk NN cord-006252-cbelsymu 217 8 persons person NNS cord-006252-cbelsymu 217 9 ( ( -LRB- cord-006252-cbelsymu 217 10 e.g. e.g. RB cord-006252-cbelsymu 217 11 visiting visit VBG cord-006252-cbelsymu 217 12 nurses nurse NNS cord-006252-cbelsymu 217 13 , , , cord-006252-cbelsymu 217 14 volunteer volunteer NN cord-006252-cbelsymu 217 15 workers worker NNS cord-006252-cbelsymu 217 16 ) ) -RRB- cord-006252-cbelsymu 217 17 . . . cord-006252-cbelsymu 218 1 Other other JJ cord-006252-cbelsymu 218 2 groups group NNS cord-006252-cbelsymu 218 3 merit merit NN cord-006252-cbelsymu 218 4 consideration consideration NN cord-006252-cbelsymu 218 5 ( ( -LRB- cord-006252-cbelsymu 218 6 Recommendations Recommendations NNPS cord-006252-cbelsymu 218 7 of of IN cord-006252-cbelsymu 218 8 the the DT cord-006252-cbelsymu 218 9 Immunization Immunization NNP cord-006252-cbelsymu 218 10 Practices Practices NNPS cord-006252-cbelsymu 218 11 Advisory Advisory NNP cord-006252-cbelsymu 218 12 Committee Committee NNP cord-006252-cbelsymu 218 13 1990 1990 CD cord-006252-cbelsymu 218 14 ) ) -RRB- cord-006252-cbelsymu 218 15 : : : cord-006252-cbelsymu 218 16 ( ( -LRB- cord-006252-cbelsymu 218 17 a a LS cord-006252-cbelsymu 218 18 ) ) -RRB- cord-006252-cbelsymu 218 19 in in IN cord-006252-cbelsymu 218 20 the the DT cord-006252-cbelsymu 218 21 general general JJ cord-006252-cbelsymu 218 22 population population NN cord-006252-cbelsymu 218 23 , , , cord-006252-cbelsymu 218 24 anyone anyone NN cord-006252-cbelsymu 218 25 who who WP cord-006252-cbelsymu 218 26 wishes wish VBZ cord-006252-cbelsymu 218 27 to to TO cord-006252-cbelsymu 218 28 reduce reduce VB cord-006252-cbelsymu 218 29 the the DT cord-006252-cbelsymu 218 30 chance chance NN cord-006252-cbelsymu 218 31 of of IN cord-006252-cbelsymu 218 32 acquiring acquire VBG cord-006252-cbelsymu 218 33 influenza influenza NN cord-006252-cbelsymu 218 34 infection infection NN cord-006252-cbelsymu 218 35 ; ; : cord-006252-cbelsymu 219 1 ( ( -LRB- cord-006252-cbelsymu 219 2 b b NN cord-006252-cbelsymu 219 3 ) ) -RRB- cord-006252-cbelsymu 219 4 anyone anyone NN cord-006252-cbelsymu 219 5 who who WP cord-006252-cbelsymu 219 6 provides provide VBZ cord-006252-cbelsymu 219 7 essential essential JJ cord-006252-cbelsymu 219 8 community community NN cord-006252-cbelsymu 219 9 services service NNS cord-006252-cbelsymu 219 10 and and CC cord-006252-cbelsymu 219 11 persons person NNS cord-006252-cbelsymu 219 12 living live VBG cord-006252-cbelsymu 219 13 or or CC cord-006252-cbelsymu 219 14 working work VBG cord-006252-cbelsymu 219 15 in in IN cord-006252-cbelsymu 219 16 an an DT cord-006252-cbelsymu 219 17 institutional institutional JJ cord-006252-cbelsymu 219 18 setting setting NN cord-006252-cbelsymu 219 19 ; ; : cord-006252-cbelsymu 220 1 ( ( -LRB- cord-006252-cbelsymu 220 2 c c NN cord-006252-cbelsymu 220 3 ) ) -RRB- cord-006252-cbelsymu 220 4 persons person NNS cord-006252-cbelsymu 220 5 infected infect VBN cord-006252-cbelsymu 220 6 with with IN cord-006252-cbelsymu 220 7 HIV HIV NNP cord-006252-cbelsymu 220 8 should should MD cord-006252-cbelsymu 220 9 be be VB cord-006252-cbelsymu 220 10 vaccinated vaccinate VBN cord-006252-cbelsymu 220 11 , , , cord-006252-cbelsymu 220 12 although although IN cord-006252-cbelsymu 220 13 they -PRON- PRP cord-006252-cbelsymu 220 14 may may MD cord-006252-cbelsymu 220 15 not not RB cord-006252-cbelsymu 220 16 respond respond VB cord-006252-cbelsymu 220 17 as as RB cord-006252-cbelsymu 220 18 well well RB cord-006252-cbelsymu 220 19 if if IN cord-006252-cbelsymu 220 20 their -PRON- PRP$ cord-006252-cbelsymu 220 21 disease disease NN cord-006252-cbelsymu 220 22 is be VBZ cord-006252-cbelsymu 220 23 far far RB cord-006252-cbelsymu 220 24 advanced advanced JJ cord-006252-cbelsymu 220 25 ; ; : cord-006252-cbelsymu 220 26 and and CC cord-006252-cbelsymu 220 27 ( ( -LRB- cord-006252-cbelsymu 220 28 d d LS cord-006252-cbelsymu 220 29 ) ) -RRB- cord-006252-cbelsymu 220 30 foreign foreign JJ cord-006252-cbelsymu 220 31 travellers traveller NNS cord-006252-cbelsymu 220 32 should should MD cord-006252-cbelsymu 220 33 be be VB cord-006252-cbelsymu 220 34 immunised immunise VBN cord-006252-cbelsymu 220 35 when when WRB cord-006252-cbelsymu 220 36 travelling travel VBG cord-006252-cbelsymu 220 37 to to IN cord-006252-cbelsymu 220 38 the the DT cord-006252-cbelsymu 220 39 trop trop NNP cord-006252-cbelsymu 220 40 - - HYPH cord-006252-cbelsymu 220 41 Prevention Prevention NNP cord-006252-cbelsymu 220 42 and and CC cord-006252-cbelsymu 220 43 Treatment Treatment NNP cord-006252-cbelsymu 220 44 of of IN cord-006252-cbelsymu 220 45 Influenza Influenza NNP cord-006252-cbelsymu 220 46 implication implication NN cord-006252-cbelsymu 220 47 here here RB cord-006252-cbelsymu 221 1 is be VBZ cord-006252-cbelsymu 221 2 that that DT cord-006252-cbelsymu 221 3 B b NN cord-006252-cbelsymu 221 4 cell cell NN cord-006252-cbelsymu 221 5 epitopes epitope NNS cord-006252-cbelsymu 221 6 are be VBP cord-006252-cbelsymu 221 7 intact intact JJ cord-006252-cbelsymu 221 8 external external JJ cord-006252-cbelsymu 221 9 molecules molecule NNS cord-006252-cbelsymu 221 10 such such JJ cord-006252-cbelsymu 221 11 as as IN cord-006252-cbelsymu 221 12 haemagglutinins haemagglutinins NNP cord-006252-cbelsymu 221 13 , , , cord-006252-cbelsymu 221 14 while while IN cord-006252-cbelsymu 221 15 T T NNP cord-006252-cbelsymu 221 16 cell cell NN cord-006252-cbelsymu 221 17 epitopes epitope NNS cord-006252-cbelsymu 221 18 appear appear VBP cord-006252-cbelsymu 221 19 to to TO cord-006252-cbelsymu 221 20 be be VB cord-006252-cbelsymu 221 21 linear linear JJ cord-006252-cbelsymu 221 22 sequences sequence NNS cord-006252-cbelsymu 221 23 exposed expose VBN cord-006252-cbelsymu 221 24 by by IN cord-006252-cbelsymu 221 25 enzymatic enzymatic JJ cord-006252-cbelsymu 221 26 breakdown breakdown NN cord-006252-cbelsymu 221 27 of of IN cord-006252-cbelsymu 221 28 the the DT cord-006252-cbelsymu 221 29 original original JJ cord-006252-cbelsymu 221 30 molecule molecule NN cord-006252-cbelsymu 221 31 . . . cord-006252-cbelsymu 222 1 A a DT cord-006252-cbelsymu 222 2 killed kill VBN cord-006252-cbelsymu 222 3 ( ( -LRB- cord-006252-cbelsymu 222 4 inactivated inactivate VBN cord-006252-cbelsymu 222 5 ) ) -RRB- cord-006252-cbelsymu 222 6 vaccine vaccine NN cord-006252-cbelsymu 222 7 against against IN cord-006252-cbelsymu 222 8 influenza influenza NN cord-006252-cbelsymu 222 9 virus virus NN cord-006252-cbelsymu 222 10 was be VBD cord-006252-cbelsymu 222 11 first first RB cord-006252-cbelsymu 222 12 developed develop VBN cord-006252-cbelsymu 222 13 in in IN cord-006252-cbelsymu 222 14 the the DT cord-006252-cbelsymu 222 15 1940s 1940 NNS cord-006252-cbelsymu 222 16 . . . cord-006252-cbelsymu 223 1 Since since IN cord-006252-cbelsymu 223 2 then then RB cord-006252-cbelsymu 223 3 the the DT cord-006252-cbelsymu 223 4 manufacturing manufacturing NN cord-006252-cbelsymu 223 5 process process NN cord-006252-cbelsymu 223 6 has have VBZ cord-006252-cbelsymu 223 7 resulted result VBN cord-006252-cbelsymu 223 8 in in IN cord-006252-cbelsymu 223 9 a a DT cord-006252-cbelsymu 223 10 more more RBR cord-006252-cbelsymu 223 11 pure pure JJ cord-006252-cbelsymu 223 12 vaccine vaccine NN cord-006252-cbelsymu 223 13 . . . cord-006252-cbelsymu 224 1 The the DT cord-006252-cbelsymu 224 2 virus virus NN cord-006252-cbelsymu 224 3 is be VBZ cord-006252-cbelsymu 224 4 grown grow VBN cord-006252-cbelsymu 224 5 in in IN cord-006252-cbelsymu 224 6 embryonated embryonate VBN cord-006252-cbelsymu 224 7 eggs egg NNS cord-006252-cbelsymu 224 8 . . . cord-006252-cbelsymu 225 1 Most Most JJS cord-006252-cbelsymu 225 2 of of IN cord-006252-cbelsymu 225 3 the the DT cord-006252-cbelsymu 225 4 egg egg NN cord-006252-cbelsymu 225 5 protein protein NN cord-006252-cbelsymu 225 6 is be VBZ cord-006252-cbelsymu 225 7 now now RB cord-006252-cbelsymu 225 8 eliminated eliminate VBN cord-006252-cbelsymu 225 9 and and CC cord-006252-cbelsymu 225 10 the the DT cord-006252-cbelsymu 225 11 side side NN cord-006252-cbelsymu 225 12 effects effect NNS cord-006252-cbelsymu 225 13 have have VBP cord-006252-cbelsymu 225 14 been be VBN cord-006252-cbelsymu 225 15 reduced reduce VBN cord-006252-cbelsymu 225 16 markedly markedly RB cord-006252-cbelsymu 225 17 . . . cord-006252-cbelsymu 226 1 Killed kill VBN cord-006252-cbelsymu 226 2 vaccines vaccine NNS cord-006252-cbelsymu 226 3 are be VBP cord-006252-cbelsymu 226 4 referred refer VBN cord-006252-cbelsymu 226 5 to to IN cord-006252-cbelsymu 226 6 as as IN cord-006252-cbelsymu 226 7 either either CC cord-006252-cbelsymu 226 8 whole whole JJ cord-006252-cbelsymu 226 9 virus virus NN cord-006252-cbelsymu 226 10 or or CC cord-006252-cbelsymu 226 11 split split NN cord-006252-cbelsymu 226 12 virus virus NN cord-006252-cbelsymu 226 13 : : : cord-006252-cbelsymu 227 1 whole whole JJ cord-006252-cbelsymu 227 2 virus virus NN cord-006252-cbelsymu 227 3 vaccines vaccine NNS cord-006252-cbelsymu 227 4 are be VBP cord-006252-cbelsymu 227 5 inactivated inactivate VBN cord-006252-cbelsymu 227 6 by by IN cord-006252-cbelsymu 227 7 formalin formalin NN cord-006252-cbelsymu 227 8 ; ; : cord-006252-cbelsymu 227 9 split split NN cord-006252-cbelsymu 227 10 or or CC cord-006252-cbelsymu 227 11 subunit subunit NN cord-006252-cbelsymu 227 12 vaccines vaccine NNS cord-006252-cbelsymu 227 13 use use VBP cord-006252-cbelsymu 227 14 whole whole JJ cord-006252-cbelsymu 227 15 virus virus NN cord-006252-cbelsymu 227 16 which which WDT cord-006252-cbelsymu 227 17 is be VBZ cord-006252-cbelsymu 227 18 treated treat VBN cord-006252-cbelsymu 227 19 with with IN cord-006252-cbelsymu 227 20 a a DT cord-006252-cbelsymu 227 21 detergent detergent NN cord-006252-cbelsymu 227 22 to to TO cord-006252-cbelsymu 227 23 free free VB cord-006252-cbelsymu 227 24 up up RP cord-006252-cbelsymu 227 25 the the DT cord-006252-cbelsymu 227 26 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 227 27 and and CC cord-006252-cbelsymu 227 28 neuraminidase neuraminidase NN cord-006252-cbelsymu 227 29 subunits subunit NNS cord-006252-cbelsymu 227 30 from from IN cord-006252-cbelsymu 227 31 the the DT cord-006252-cbelsymu 227 32 viral viral JJ cord-006252-cbelsymu 227 33 surface surface NN cord-006252-cbelsymu 227 34 , , , cord-006252-cbelsymu 227 35 then then RB cord-006252-cbelsymu 227 36 formalin formalin NN cord-006252-cbelsymu 227 37 is be VBZ cord-006252-cbelsymu 227 38 added add VBN cord-006252-cbelsymu 227 39 . . . cord-006252-cbelsymu 228 1 In in IN cord-006252-cbelsymu 228 2 children child NNS cord-006252-cbelsymu 228 3 who who WP cord-006252-cbelsymu 228 4 have have VBP cord-006252-cbelsymu 228 5 not not RB cord-006252-cbelsymu 228 6 previously previously RB cord-006252-cbelsymu 228 7 been be VBN cord-006252-cbelsymu 228 8 vaccinated vaccinate VBN cord-006252-cbelsymu 228 9 , , , cord-006252-cbelsymu 228 10 split split VBN cord-006252-cbelsymu 228 11 virus virus NN cord-006252-cbelsymu 228 12 vaccines vaccine NNS cord-006252-cbelsymu 228 13 cause cause VBP cord-006252-cbelsymu 228 14 fewer few JJR cord-006252-cbelsymu 228 15 side side NN cord-006252-cbelsymu 228 16 effects effect NNS cord-006252-cbelsymu 228 17 such such JJ cord-006252-cbelsymu 228 18 as as IN cord-006252-cbelsymu 228 19 fever fever NN cord-006252-cbelsymu 228 20 and and CC cord-006252-cbelsymu 228 21 myalgias myalgia NNS cord-006252-cbelsymu 228 22 than than IN cord-006252-cbelsymu 228 23 whole whole JJ cord-006252-cbelsymu 228 24 virus virus NN cord-006252-cbelsymu 228 25 vaccines vaccine NNS cord-006252-cbelsymu 228 26 . . . cord-006252-cbelsymu 229 1 Live live JJ cord-006252-cbelsymu 229 2 attenuated attenuated JJ cord-006252-cbelsymu 229 3 vaccines vaccine NNS cord-006252-cbelsymu 229 4 have have VBP cord-006252-cbelsymu 229 5 been be VBN cord-006252-cbelsymu 229 6 in in IN cord-006252-cbelsymu 229 7 the the DT cord-006252-cbelsymu 229 8 development development NN cord-006252-cbelsymu 229 9 stages stage NNS cord-006252-cbelsymu 229 10 for for IN cord-006252-cbelsymu 229 11 over over IN cord-006252-cbelsymu 229 12 10 10 CD cord-006252-cbelsymu 229 13 years year NNS cord-006252-cbelsymu 229 14 and and CC cord-006252-cbelsymu 229 15 are be VBP cord-006252-cbelsymu 229 16 currently currently RB cord-006252-cbelsymu 229 17 being be VBG cord-006252-cbelsymu 229 18 tested test VBN cord-006252-cbelsymu 229 19 ; ; : cord-006252-cbelsymu 229 20 they -PRON- PRP cord-006252-cbelsymu 229 21 are be VBP cord-006252-cbelsymu 229 22 not not RB cord-006252-cbelsymu 229 23 commercially commercially RB cord-006252-cbelsymu 229 24 available available JJ cord-006252-cbelsymu 229 25 . . . cord-006252-cbelsymu 230 1 A a DT cord-006252-cbelsymu 230 2 genetically genetically RB cord-006252-cbelsymu 230 3 stable stable JJ cord-006252-cbelsymu 230 4 method method NN cord-006252-cbelsymu 230 5 of of IN cord-006252-cbelsymu 230 6 production production NN cord-006252-cbelsymu 230 7 was be VBD cord-006252-cbelsymu 230 8 the the DT cord-006252-cbelsymu 230 9 initial initial JJ cord-006252-cbelsymu 230 10 problem problem NN cord-006252-cbelsymu 230 11 but but CC cord-006252-cbelsymu 230 12 this this DT cord-006252-cbelsymu 230 13 has have VBZ cord-006252-cbelsymu 230 14 since since IN cord-006252-cbelsymu 230 15 been be VBN cord-006252-cbelsymu 230 16 solved solve VBN cord-006252-cbelsymu 230 17 . . . cord-006252-cbelsymu 231 1 However however RB cord-006252-cbelsymu 231 2 , , , cord-006252-cbelsymu 231 3 it -PRON- PRP cord-006252-cbelsymu 231 4 has have VBZ cord-006252-cbelsymu 231 5 been be VBN cord-006252-cbelsymu 231 6 difficult difficult JJ cord-006252-cbelsymu 231 7 to to TO cord-006252-cbelsymu 231 8 show show VB cord-006252-cbelsymu 231 9 a a DT cord-006252-cbelsymu 231 10 clear clear JJ cord-006252-cbelsymu 231 11 advantage advantage NN cord-006252-cbelsymu 231 12 of of IN cord-006252-cbelsymu 231 13 live live NN cord-006252-cbelsymu 231 14 over over IN cord-006252-cbelsymu 231 15 killed kill VBN cord-006252-cbelsymu 231 16 vaccines vaccine NNS cord-006252-cbelsymu 231 17 . . . cord-006252-cbelsymu 232 1 The the DT cord-006252-cbelsymu 232 2 currently currently RB cord-006252-cbelsymu 232 3 licensed license VBN cord-006252-cbelsymu 232 4 influenza influenza NN cord-006252-cbelsymu 232 5 vaccine vaccine NN cord-006252-cbelsymu 232 6 contains contain VBZ cord-006252-cbelsymu 232 7 3 3 CD cord-006252-cbelsymu 232 8 strains strain NNS cord-006252-cbelsymu 232 9 : : : cord-006252-cbelsymu 232 10 influenza influenza NNP cord-006252-cbelsymu 232 11 A A NNP cord-006252-cbelsymu 232 12 / / SYM cord-006252-cbelsymu 232 13 Shanghai Shanghai NNP cord-006252-cbelsymu 232 14 / / SYM cord-006252-cbelsymu 232 15 I -PRON- PRP cord-006252-cbelsymu 232 16 6/89 6/89 CD cord-006252-cbelsymu 232 17 ( ( -LRB- cord-006252-cbelsymu 232 18 H3N2 H3N2 NNP cord-006252-cbelsymu 232 19 ) ) -RRB- cord-006252-cbelsymu 232 20 ; ; : cord-006252-cbelsymu 232 21 influenza influenza NN cord-006252-cbelsymu 232 22 A A NNP cord-006252-cbelsymu 232 23 / / SYM cord-006252-cbelsymu 232 24 Taiwan Taiwan NNP cord-006252-cbelsymu 232 25 / / , cord-006252-cbelsymu 232 26 I/86 i/86 NN cord-006252-cbelsymu 232 27 ( ( -LRB- cord-006252-cbelsymu 232 28 HIN HIN NNP cord-006252-cbelsymu 232 29 J J NNP cord-006252-cbelsymu 232 30 ) ) -RRB- cord-006252-cbelsymu 232 31 ; ; : cord-006252-cbelsymu 232 32 and and CC cord-006252-cbelsymu 233 1 influenza influenza NN cord-006252-cbelsymu 233 2 B/ B/ NNP cord-006252-cbelsymu 233 3 Yamagata Yamagata NNP cord-006252-cbelsymu 233 4 / / SYM cord-006252-cbelsymu 233 5 I I NNP cord-006252-cbelsymu 233 6 6/88 6/88 CD cord-006252-cbelsymu 233 7 . . . cord-006252-cbelsymu 234 1 There there EX cord-006252-cbelsymu 234 2 are be VBP cord-006252-cbelsymu 234 3 15J.Lg 15j.lg CD cord-006252-cbelsymu 234 4 of of IN cord-006252-cbelsymu 234 5 haemagglutinin haemagglutinin NNP cord-006252-cbelsymu 234 6 for for IN cord-006252-cbelsymu 234 7 each each DT cord-006252-cbelsymu 234 8 strain strain NN cord-006252-cbelsymu 234 9 in in IN cord-006252-cbelsymu 234 10 the the DT cord-006252-cbelsymu 234 11 vaccine vaccine NN cord-006252-cbelsymu 234 12 . . . cord-006252-cbelsymu 235 1 It -PRON- PRP cord-006252-cbelsymu 235 2 should should MD cord-006252-cbelsymu 235 3 be be VB cord-006252-cbelsymu 235 4 given give VBN cord-006252-cbelsymu 235 5 intramuscularly intramuscularly RB cord-006252-cbelsymu 235 6 in in IN cord-006252-cbelsymu 235 7 the the DT cord-006252-cbelsymu 235 8 deltoid deltoid NN cord-006252-cbelsymu 235 9 in in IN cord-006252-cbelsymu 235 10 adults adult NNS cord-006252-cbelsymu 235 11 and and CC cord-006252-cbelsymu 235 12 in in IN cord-006252-cbelsymu 235 13 the the DT cord-006252-cbelsymu 235 14 anterolateral anterolateral JJ cord-006252-cbelsymu 235 15 thigh thigh NN cord-006252-cbelsymu 235 16 in in IN cord-006252-cbelsymu 235 17 infants infant NNS cord-006252-cbelsymu 235 18 and and CC cord-006252-cbelsymu 235 19 young young JJ cord-006252-cbelsymu 235 20 children child NNS cord-006252-cbelsymu 235 21 . . . cord-006252-cbelsymu 236 1 Administration administration NN cord-006252-cbelsymu 236 2 in in IN cord-006252-cbelsymu 236 3 the the DT cord-006252-cbelsymu 236 4 buttock buttock NN cord-006252-cbelsymu 236 5 is be VBZ cord-006252-cbelsymu 236 6 not not RB cord-006252-cbelsymu 236 7 recommended recommend VBN cord-006252-cbelsymu 236 8 because because IN cord-006252-cbelsymu 236 9 it -PRON- PRP cord-006252-cbelsymu 236 10 may may MD cord-006252-cbelsymu 236 11 result result VB cord-006252-cbelsymu 236 12 in in IN cord-006252-cbelsymu 236 13 a a DT cord-006252-cbelsymu 236 14 poorer poor JJR cord-006252-cbelsymu 236 15 immune immune JJ cord-006252-cbelsymu 236 16 response response NN cord-006252-cbelsymu 236 17 due due IN cord-006252-cbelsymu 236 18 to to IN cord-006252-cbelsymu 236 19 inadequate inadequate JJ cord-006252-cbelsymu 236 20 absorption absorption NN cord-006252-cbelsymu 236 21 from from IN cord-006252-cbelsymu 236 22 the the DT cord-006252-cbelsymu 236 23 subcutaneous subcutaneous JJ cord-006252-cbelsymu 236 24 fat fat NN cord-006252-cbelsymu 236 25 . . . cord-006252-cbelsymu 237 1 The the DT cord-006252-cbelsymu 237 2 strains strain NNS cord-006252-cbelsymu 237 3 to to TO cord-006252-cbelsymu 237 4 be be VB cord-006252-cbelsymu 237 5 included include VBN cord-006252-cbelsymu 237 6 in in IN cord-006252-cbelsymu 237 7 the the DT cord-006252-cbelsymu 237 8 vaccine vaccine NN cord-006252-cbelsymu 237 9 change change NN cord-006252-cbelsymu 237 10 from from IN cord-006252-cbelsymu 237 11 year year NN cord-006252-cbelsymu 237 12 to to IN cord-006252-cbelsymu 237 13 year year NN cord-006252-cbelsymu 237 14 according accord VBG cord-006252-cbelsymu 237 15 to to IN cord-006252-cbelsymu 237 16 World World NNP cord-006252-cbelsymu 237 17 Health Health NNP cord-006252-cbelsymu 237 18 Organization Organization NNP cord-006252-cbelsymu 237 19 ( ( -LRB- cord-006252-cbelsymu 237 20 WHO who WP cord-006252-cbelsymu 237 21 ) ) -RRB- cord-006252-cbelsymu 237 22 recommendations recommendation NNS cord-006252-cbelsymu 237 23 . . . cord-006252-cbelsymu 238 1 435 435 CD cord-006252-cbelsymu 238 2 _SP cord-006252-cbelsymu 239 1 The the DT cord-006252-cbelsymu 239 2 primary primary JJ cord-006252-cbelsymu 239 3 target target NN cord-006252-cbelsymu 239 4 groups group NNS cord-006252-cbelsymu 239 5 are be VBP cord-006252-cbelsymu 239 6 as as IN cord-006252-cbelsymu 239 7 follows follow VBZ cord-006252-cbelsymu 240 1 ( ( -LRB- cord-006252-cbelsymu 240 2 Recommendations Recommendations NNPS cord-006252-cbelsymu 240 3 of of IN cord-006252-cbelsymu 240 4 the the DT cord-006252-cbelsymu 240 5 Immunization Immunization NNP cord-006252-cbelsymu 240 6 Practices Practices NNPS cord-006252-cbelsymu 240 7 Advisory Advisory NNP cord-006252-cbelsymu 240 8 Committee Committee NNP cord-006252-cbelsymu 240 9 1990 1990 CD cord-006252-cbelsymu 240 10 ) ) -RRB- cord-006252-cbelsymu 240 11 . . . cord-006252-cbelsymu 241 1 I. I. NNP cord-006252-cbelsymu 241 2 Persons person NNS cord-006252-cbelsymu 241 3 aged age VBN cord-006252-cbelsymu 241 4 65 65 CD cord-006252-cbelsymu 241 5 years year NNS cord-006252-cbelsymu 241 6 or or CC cord-006252-cbelsymu 241 7 older old JJR cord-006252-cbelsymu 241 8 . . . cord-006252-cbelsymu 242 1 2 2 LS cord-006252-cbelsymu 242 2 . . . cord-006252-cbelsymu 243 1 Residents resident NNS cord-006252-cbelsymu 243 2 of of IN cord-006252-cbelsymu 243 3 nursing nursing NN cord-006252-cbelsymu 243 4 homes home NNS cord-006252-cbelsymu 243 5 and and CC cord-006252-cbelsymu 243 6 other other JJ cord-006252-cbelsymu 243 7 chronic chronic NN cord-006252-cbelsymu 243 8 - - HYPH cord-006252-cbelsymu 243 9 care care NN cord-006252-cbelsymu 243 10 facilities facility NNS cord-006252-cbelsymu 243 11 housing housing NN cord-006252-cbelsymu 243 12 persons person NNS cord-006252-cbelsymu 243 13 of of IN cord-006252-cbelsymu 243 14 any any DT cord-006252-cbelsymu 243 15 age age NN cord-006252-cbelsymu 243 16 with with IN cord-006252-cbelsymu 243 17 chronic chronic JJ cord-006252-cbelsymu 243 18 medical medical JJ cord-006252-cbelsymu 243 19 conditions condition NNS cord-006252-cbelsymu 243 20 . . . cord-006252-cbelsymu 244 1 3 3 LS cord-006252-cbelsymu 244 2 . . . cord-006252-cbelsymu 245 1 Adults adult NNS cord-006252-cbelsymu 245 2 and and CC cord-006252-cbelsymu 245 3 children child NNS cord-006252-cbelsymu 245 4 with with IN cord-006252-cbelsymu 245 5 chronic chronic JJ cord-006252-cbelsymu 245 6 disorders disorder NNS cord-006252-cbelsymu 245 7 of of IN cord-006252-cbelsymu 245 8 the the DT cord-006252-cbelsymu 245 9 pulmonary pulmonary JJ cord-006252-cbelsymu 245 10 or or CC cord-006252-cbelsymu 245 11 cardiovascular cardiovascular JJ cord-006252-cbelsymu 245 12 systems system NNS cord-006252-cbelsymu 245 13 , , , cord-006252-cbelsymu 245 14 including include VBG cord-006252-cbelsymu 245 15 children child NNS cord-006252-cbelsymu 245 16 with with IN cord-006252-cbelsymu 245 17 asthma asthma NN cord-006252-cbelsymu 245 18 . . . cord-006252-cbelsymu 246 1 4 4 LS cord-006252-cbelsymu 246 2 . . . cord-006252-cbelsymu 247 1 Adults adult NNS cord-006252-cbelsymu 247 2 and and CC cord-006252-cbelsymu 247 3 children child NNS cord-006252-cbelsymu 247 4 who who WP cord-006252-cbelsymu 247 5 have have VBP cord-006252-cbelsymu 247 6 required require VBN cord-006252-cbelsymu 247 7 regular regular JJ cord-006252-cbelsymu 247 8 medical medical JJ cord-006252-cbelsymu 247 9 follow follow NN cord-006252-cbelsymu 247 10 - - HYPH cord-006252-cbelsymu 247 11 up up NN cord-006252-cbelsymu 247 12 or or CC cord-006252-cbelsymu 247 13 hospitalisation hospitalisation NN cord-006252-cbelsymu 247 14 during during IN cord-006252-cbelsymu 247 15 the the DT cord-006252-cbelsymu 247 16 preceding precede VBG cord-006252-cbelsymu 247 17 year year NN cord-006252-cbelsymu 247 18 because because IN cord-006252-cbelsymu 247 19 of of IN cord-006252-cbelsymu 247 20 chronic chronic JJ cord-006252-cbelsymu 247 21 metabolic metabolic JJ cord-006252-cbelsymu 247 22 diseases disease NNS cord-006252-cbelsymu 247 23 ( ( -LRB- cord-006252-cbelsymu 247 24 including include VBG cord-006252-cbelsymu 247 25 diabetes diabetes NN cord-006252-cbelsymu 247 26 mellitus mellitus NN cord-006252-cbelsymu 247 27 ) ) -RRB- cord-006252-cbelsymu 247 28 , , , cord-006252-cbelsymu 247 29 renal renal JJ cord-006252-cbelsymu 247 30 dysfunction dysfunction NN cord-006252-cbelsymu 247 31 , , , cord-006252-cbelsymu 247 32 haemoglobinopathies haemoglobinopathy NNS cord-006252-cbelsymu 247 33 , , , cord-006252-cbelsymu 247 34 or or CC cord-006252-cbelsymu 247 35 immunosuppression immunosuppression NN cord-006252-cbelsymu 247 36 ( ( -LRB- cord-006252-cbelsymu 247 37 including include VBG cord-006252-cbelsymu 247 38 immunosuppression immunosuppression NN cord-006252-cbelsymu 247 39 caused cause VBN cord-006252-cbelsymu 247 40 by by IN cord-006252-cbelsymu 247 41 medications medication NNS cord-006252-cbelsymu 247 42 ) ) -RRB- cord-006252-cbelsymu 247 43 . . . cord-006252-cbelsymu 248 1 I. I. NNP cord-006252-cbelsymu 248 2 Physicians Physicians NNP cord-006252-cbelsymu 248 3 , , , cord-006252-cbelsymu 248 4 nurses nurse NNS cord-006252-cbelsymu 248 5 and and CC cord-006252-cbelsymu 248 6 other other JJ cord-006252-cbelsymu 248 7 personnel personnel NNS cord-006252-cbelsymu 248 8 in in IN cord-006252-cbelsymu 248 9 both both DT cord-006252-cbelsymu 248 10 hospital hospital NN cord-006252-cbelsymu 248 11 and and CC cord-006252-cbelsymu 248 12 outpatient outpatient NN cord-006252-cbelsymu 248 13 - - HYPH cord-006252-cbelsymu 248 14 care care NN cord-006252-cbelsymu 248 15 settings setting NNS cord-006252-cbelsymu 248 16 who who WP cord-006252-cbelsymu 248 17 have have VBP cord-006252-cbelsymu 248 18 contact contact NN cord-006252-cbelsymu 248 19 with with IN cord-006252-cbelsymu 248 20 high high JJ cord-006252-cbelsymu 248 21 - - HYPH cord-006252-cbelsymu 248 22 risk risk NN cord-006252-cbelsymu 248 23 persons person NNS cord-006252-cbelsymu 248 24 in in IN cord-006252-cbelsymu 248 25 all all DT cord-006252-cbelsymu 248 26 age age NN cord-006252-cbelsymu 248 27 groups group NNS cord-006252-cbelsymu 248 28 , , , cord-006252-cbelsymu 248 29 including include VBG cord-006252-cbelsymu 248 30 infants infant NNS cord-006252-cbelsymu 248 31 . . . cord-006252-cbelsymu 249 1 2 2 LS cord-006252-cbelsymu 249 2 . . . cord-006252-cbelsymu 250 1 Employees employee NNS cord-006252-cbelsymu 250 2 of of IN cord-006252-cbelsymu 250 3 nursing nursing NN cord-006252-cbelsymu 250 4 homes home NNS cord-006252-cbelsymu 250 5 and and CC cord-006252-cbelsymu 250 6 chronic chronic JJ cord-006252-cbelsymu 250 7 - - HYPH cord-006252-cbelsymu 250 8 care care NN cord-006252-cbelsymu 250 9 facilities facility NNS cord-006252-cbelsymu 250 10 who who WP cord-006252-cbelsymu 250 11 have have VBP cord-006252-cbelsymu 250 12 contact contact NN cord-006252-cbelsymu 250 13 with with IN cord-006252-cbelsymu 250 14 patients patient NNS cord-006252-cbelsymu 250 15 or or CC cord-006252-cbelsymu 250 16 residents resident NNS cord-006252-cbelsymu 250 17 . . . cord-006252-cbelsymu 251 1 3 3 LS cord-006252-cbelsymu 251 2 . . . cord-006252-cbelsymu 252 1 Providers provider NNS cord-006252-cbelsymu 252 2 of of IN cord-006252-cbelsymu 252 3 home home NN cord-006252-cbelsymu 252 4 care care NN cord-006252-cbelsymu 252 5 to to IN cord-006252-cbelsymu 252 6 high high JJ cord-006252-cbelsymu 252 7 risk risk NN cord-006252-cbelsymu 252 8 persons person NNS cord-006252-cbelsymu 252 9 ( ( -LRB- cord-006252-cbelsymu 252 10 e.g. e.g. RB cord-006252-cbelsymu 252 11 visiting visit VBG cord-006252-cbelsymu 252 12 nurses nurse NNS cord-006252-cbelsymu 252 13 , , , cord-006252-cbelsymu 252 14 volunteer volunteer NN cord-006252-cbelsymu 252 15 workers worker NNS cord-006252-cbelsymu 252 16 ) ) -RRB- cord-006252-cbelsymu 252 17 . . . cord-006252-cbelsymu 253 1 Other other JJ cord-006252-cbelsymu 253 2 groups group NNS cord-006252-cbelsymu 253 3 merit merit NN cord-006252-cbelsymu 253 4 consideration consideration NN cord-006252-cbelsymu 253 5 ( ( -LRB- cord-006252-cbelsymu 253 6 Recommendations Recommendations NNPS cord-006252-cbelsymu 253 7 of of IN cord-006252-cbelsymu 253 8 the the DT cord-006252-cbelsymu 253 9 Immunization Immunization NNP cord-006252-cbelsymu 253 10 Practices Practices NNPS cord-006252-cbelsymu 253 11 Advisory Advisory NNP cord-006252-cbelsymu 253 12 Committee Committee NNP cord-006252-cbelsymu 253 13 1990 1990 CD cord-006252-cbelsymu 253 14 ) ) -RRB- cord-006252-cbelsymu 253 15 : : : cord-006252-cbelsymu 253 16 ( ( -LRB- cord-006252-cbelsymu 253 17 a a LS cord-006252-cbelsymu 253 18 ) ) -RRB- cord-006252-cbelsymu 253 19 in in IN cord-006252-cbelsymu 253 20 the the DT cord-006252-cbelsymu 253 21 general general JJ cord-006252-cbelsymu 253 22 population population NN cord-006252-cbelsymu 253 23 , , , cord-006252-cbelsymu 253 24 anyone anyone NN cord-006252-cbelsymu 253 25 who who WP cord-006252-cbelsymu 253 26 wishes wish VBZ cord-006252-cbelsymu 253 27 to to TO cord-006252-cbelsymu 253 28 reduce reduce VB cord-006252-cbelsymu 253 29 the the DT cord-006252-cbelsymu 253 30 chance chance NN cord-006252-cbelsymu 253 31 of of IN cord-006252-cbelsymu 253 32 acquiring acquire VBG cord-006252-cbelsymu 253 33 influenza influenza NN cord-006252-cbelsymu 253 34 infection infection NN cord-006252-cbelsymu 253 35 ; ; : cord-006252-cbelsymu 254 1 ( ( -LRB- cord-006252-cbelsymu 254 2 b b NN cord-006252-cbelsymu 254 3 ) ) -RRB- cord-006252-cbelsymu 254 4 anyone anyone NN cord-006252-cbelsymu 254 5 who who WP cord-006252-cbelsymu 254 6 provides provide VBZ cord-006252-cbelsymu 254 7 essential essential JJ cord-006252-cbelsymu 254 8 community community NN cord-006252-cbelsymu 254 9 services service NNS cord-006252-cbelsymu 254 10 and and CC cord-006252-cbelsymu 254 11 persons person NNS cord-006252-cbelsymu 254 12 living live VBG cord-006252-cbelsymu 254 13 or or CC cord-006252-cbelsymu 254 14 working work VBG cord-006252-cbelsymu 254 15 in in IN cord-006252-cbelsymu 254 16 an an DT cord-006252-cbelsymu 254 17 institutional institutional JJ cord-006252-cbelsymu 254 18 setting setting NN cord-006252-cbelsymu 254 19 ; ; : cord-006252-cbelsymu 255 1 ( ( -LRB- cord-006252-cbelsymu 255 2 c c NN cord-006252-cbelsymu 255 3 ) ) -RRB- cord-006252-cbelsymu 255 4 persons person NNS cord-006252-cbelsymu 255 5 infected infect VBN cord-006252-cbelsymu 255 6 with with IN cord-006252-cbelsymu 255 7 HIV HIV NNP cord-006252-cbelsymu 255 8 should should MD cord-006252-cbelsymu 255 9 be be VB cord-006252-cbelsymu 255 10 vaccinated vaccinate VBN cord-006252-cbelsymu 255 11 , , , cord-006252-cbelsymu 255 12 although although IN cord-006252-cbelsymu 255 13 they -PRON- PRP cord-006252-cbelsymu 255 14 may may MD cord-006252-cbelsymu 255 15 not not RB cord-006252-cbelsymu 255 16 respond respond VB cord-006252-cbelsymu 255 17 as as RB cord-006252-cbelsymu 255 18 well well RB cord-006252-cbelsymu 255 19 if if IN cord-006252-cbelsymu 255 20 their -PRON- PRP$ cord-006252-cbelsymu 255 21 disease disease NN cord-006252-cbelsymu 255 22 is be VBZ cord-006252-cbelsymu 255 23 far far RB cord-006252-cbelsymu 255 24 advanced advanced JJ cord-006252-cbelsymu 255 25 ; ; : cord-006252-cbelsymu 255 26 and and CC cord-006252-cbelsymu 255 27 ( ( -LRB- cord-006252-cbelsymu 255 28 d d LS cord-006252-cbelsymu 255 29 ) ) -RRB- cord-006252-cbelsymu 255 30 foreign foreign JJ cord-006252-cbelsymu 255 31 travellers traveller NNS cord-006252-cbelsymu 255 32 should should MD cord-006252-cbelsymu 255 33 be be VB cord-006252-cbelsymu 255 34 immunised immunise VBN cord-006252-cbelsymu 255 35 when when WRB cord-006252-cbelsymu 255 36 travelling travel VBG cord-006252-cbelsymu 255 37 to to IN cord-006252-cbelsymu 255 38 the the DT cord-006252-cbelsymu 255 39 trop trop NNP cord-006252-cbelsymu 255 40 - - HYPH cord-006252-cbelsymu 255 41 ics ics NNP cord-006252-cbelsymu 255 42 at at IN cord-006252-cbelsymu 255 43 any any DT cord-006252-cbelsymu 255 44 time time NN cord-006252-cbelsymu 255 45 of of IN cord-006252-cbelsymu 255 46 the the DT cord-006252-cbelsymu 255 47 year year NN cord-006252-cbelsymu 255 48 or or CC cord-006252-cbelsymu 255 49 from from IN cord-006252-cbelsymu 255 50 the the DT cord-006252-cbelsymu 255 51 Southern Southern NNP cord-006252-cbelsymu 255 52 to to IN cord-006252-cbelsymu 255 53 the the DT cord-006252-cbelsymu 255 54 Northern Northern NNP cord-006252-cbelsymu 255 55 Hemisphere Hemisphere NNP cord-006252-cbelsymu 255 56 between between IN cord-006252-cbelsymu 255 57 August August NNP cord-006252-cbelsymu 255 58 and and CC cord-006252-cbelsymu 255 59 March March NNP cord-006252-cbelsymu 255 60 and and CC cord-006252-cbelsymu 255 61 the the DT cord-006252-cbelsymu 255 62 Northern Northern NNP cord-006252-cbelsymu 255 63 to to IN cord-006252-cbelsymu 255 64 the the DT cord-006252-cbelsymu 255 65 Southern Southern NNP cord-006252-cbelsymu 255 66 Hemisphere Hemisphere NNP cord-006252-cbelsymu 255 67 between between IN cord-006252-cbelsymu 255 68 April April NNP cord-006252-cbelsymu 255 69 and and CC cord-006252-cbelsymu 255 70 September September NNP cord-006252-cbelsymu 255 71 . . . cord-006252-cbelsymu 256 1 The the DT cord-006252-cbelsymu 256 2 vaccine vaccine NN cord-006252-cbelsymu 256 3 is be VBZ cord-006252-cbelsymu 256 4 contraindicated contraindicate VBN cord-006252-cbelsymu 256 5 in in IN cord-006252-cbelsymu 256 6 persons person NNS cord-006252-cbelsymu 256 7 with with IN cord-006252-cbelsymu 256 8 anaphylaxis anaphylaxis NN cord-006252-cbelsymu 256 9 to to IN cord-006252-cbelsymu 256 10 eggs egg NNS cord-006252-cbelsymu 256 11 and and CC cord-006252-cbelsymu 256 12 in in IN cord-006252-cbelsymu 256 13 those those DT cord-006252-cbelsymu 256 14 with with IN cord-006252-cbelsymu 256 15 an an DT cord-006252-cbelsymu 256 16 acute acute JJ cord-006252-cbelsymu 256 17 febrile febrile JJ cord-006252-cbelsymu 256 18 illness illness NN cord-006252-cbelsymu 256 19 . . . cord-006252-cbelsymu 257 1 A a DT cord-006252-cbelsymu 257 2 protocol protocol NN cord-006252-cbelsymu 257 3 is be VBZ cord-006252-cbelsymu 257 4 available available JJ cord-006252-cbelsymu 257 5 for for IN cord-006252-cbelsymu 257 6 giving give VBG cord-006252-cbelsymu 257 7 vaccine vaccine NN cord-006252-cbelsymu 257 8 to to IN cord-006252-cbelsymu 257 9 allergic allergic JJ cord-006252-cbelsymu 257 10 patients patient NNS cord-006252-cbelsymu 257 11 at at IN cord-006252-cbelsymu 257 12 high high JJ cord-006252-cbelsymu 257 13 risk risk NN cord-006252-cbelsymu 257 14 of of IN cord-006252-cbelsymu 257 15 influenza influenza NN cord-006252-cbelsymu 257 16 complications complication NNS cord-006252-cbelsymu 257 17 ( ( -LRB- cord-006252-cbelsymu 257 18 Recommendations Recommendations NNPS cord-006252-cbelsymu 257 19 of of IN cord-006252-cbelsymu 257 20 the the DT cord-006252-cbelsymu 257 21 Immunization Immunization NNP cord-006252-cbelsymu 257 22 Practices Practices NNPS cord-006252-cbelsymu 257 23 Advisory Advisory NNP cord-006252-cbelsymu 257 24 Committee Committee NNP cord-006252-cbelsymu 257 25 1990 1990 CD cord-006252-cbelsymu 257 26 ) ) -RRB- cord-006252-cbelsymu 257 27 . . . cord-006252-cbelsymu 258 1 Other other JJ cord-006252-cbelsymu 258 2 vaccines vaccine NNS cord-006252-cbelsymu 258 3 can can MD cord-006252-cbelsymu 258 4 be be VB cord-006252-cbelsymu 258 5 given give VBN cord-006252-cbelsymu 258 6 along along RP cord-006252-cbelsymu 258 7 with with IN cord-006252-cbelsymu 258 8 influenza influenza NN cord-006252-cbelsymu 258 9 vaccine vaccine NN cord-006252-cbelsymu 258 10 , , , cord-006252-cbelsymu 258 11 such such JJ cord-006252-cbelsymu 258 12 as as IN cord-006252-cbelsymu 258 13 pneumococcal pneumococcal JJ cord-006252-cbelsymu 258 14 , , , cord-006252-cbelsymu 258 15 measlesmumps measlesmumps NN cord-006252-cbelsymu 258 16 - - HYPH cord-006252-cbelsymu 258 17 rubella rubella NN cord-006252-cbelsymu 258 18 , , , cord-006252-cbelsymu 258 19 Haemophilus Haemophilus NNP cord-006252-cbelsymu 258 20 inJluenzae inJluenzae NNP cord-006252-cbelsymu 258 21 type type NN cord-006252-cbelsymu 258 22 b b NN cord-006252-cbelsymu 258 23 , , , cord-006252-cbelsymu 258 24 and and CC cord-006252-cbelsymu 258 25 oral oral JJ cord-006252-cbelsymu 258 26 polio polio NN cord-006252-cbelsymu 258 27 vaccines vaccine NNS cord-006252-cbelsymu 258 28 . . . cord-006252-cbelsymu 259 1 Pertussis pertussis NN cord-006252-cbelsymu 259 2 vaccine vaccine NN cord-006252-cbelsymu 259 3 , , , cord-006252-cbelsymu 259 4 however however RB cord-006252-cbelsymu 259 5 , , , cord-006252-cbelsymu 259 6 should should MD cord-006252-cbelsymu 259 7 not not RB cord-006252-cbelsymu 259 8 be be VB cord-006252-cbelsymu 259 9 given give VBN cord-006252-cbelsymu 259 10 within within IN cord-006252-cbelsymu 259 11 3 3 CD cord-006252-cbelsymu 259 12 days day NNS cord-006252-cbelsymu 259 13 of of IN cord-006252-cbelsymu 259 14 influenza influenza NN cord-006252-cbelsymu 259 15 virus virus NN cord-006252-cbelsymu 259 16 vaccine vaccine NN cord-006252-cbelsymu 259 17 . . . cord-006252-cbelsymu 260 1 For for IN cord-006252-cbelsymu 260 2 optimal optimal JJ cord-006252-cbelsymu 260 3 effect effect NN cord-006252-cbelsymu 260 4 , , , cord-006252-cbelsymu 260 5 the the DT cord-006252-cbelsymu 260 6 vaccine vaccine NN cord-006252-cbelsymu 260 7 should should MD cord-006252-cbelsymu 260 8 be be VB cord-006252-cbelsymu 260 9 given give VBN cord-006252-cbelsymu 260 10 in in IN cord-006252-cbelsymu 260 11 November November NNP cord-006252-cbelsymu 260 12 in in IN cord-006252-cbelsymu 260 13 the the DT cord-006252-cbelsymu 260 14 Northern Northern NNP cord-006252-cbelsymu 260 15 Hemisphere Hemisphere NNP cord-006252-cbelsymu 260 16 or or CC cord-006252-cbelsymu 260 17 May May NNP cord-006252-cbelsymu 260 18 in in IN cord-006252-cbelsymu 260 19 the the DT cord-006252-cbelsymu 260 20 Southern Southern NNP cord-006252-cbelsymu 260 21 Hemisphere Hemisphere NNP cord-006252-cbelsymu 260 22 , , , cord-006252-cbelsymu 260 23 before before IN cord-006252-cbelsymu 260 24 the the DT cord-006252-cbelsymu 260 25 winter winter NN cord-006252-cbelsymu 260 26 influenza influenza NN cord-006252-cbelsymu 260 27 season season NN cord-006252-cbelsymu 260 28 begins begin VBZ cord-006252-cbelsymu 260 29 . . . cord-006252-cbelsymu 261 1 Effective effective JJ cord-006252-cbelsymu 261 2 antibody antibody NN cord-006252-cbelsymu 261 3 levels level NNS cord-006252-cbelsymu 261 4 develop develop VBP cord-006252-cbelsymu 261 5 within within IN cord-006252-cbelsymu 261 6 2 2 CD cord-006252-cbelsymu 261 7 weeks week NNS cord-006252-cbelsymu 261 8 in in IN cord-006252-cbelsymu 261 9 most most RBS cord-006252-cbelsymu 261 10 previously previously RB cord-006252-cbelsymu 261 11 immunised immunise VBN cord-006252-cbelsymu 261 12 persons person NNS cord-006252-cbelsymu 261 13 . . . cord-006252-cbelsymu 262 1 The the DT cord-006252-cbelsymu 262 2 levels level NNS cord-006252-cbelsymu 262 3 decline decline VBP cord-006252-cbelsymu 262 4 a a DT cord-006252-cbelsymu 262 5 few few JJ cord-006252-cbelsymu 262 6 months month NNS cord-006252-cbelsymu 262 7 later later RB cord-006252-cbelsymu 262 8 , , , cord-006252-cbelsymu 262 9 when when WRB cord-006252-cbelsymu 262 10 they -PRON- PRP cord-006252-cbelsymu 262 11 may may MD cord-006252-cbelsymu 262 12 be be VB cord-006252-cbelsymu 262 13 suboptimal suboptimal JJ cord-006252-cbelsymu 262 14 . . . cord-006252-cbelsymu 263 1 Studies study NNS cord-006252-cbelsymu 263 2 investigating investigate VBG cord-006252-cbelsymu 263 3 vaccine vaccine NN cord-006252-cbelsymu 263 4 efficacy efficacy NN cord-006252-cbelsymu 263 5 are be VBP cord-006252-cbelsymu 263 6 difficult difficult JJ cord-006252-cbelsymu 263 7 to to TO cord-006252-cbelsymu 263 8 conduct conduct VB cord-006252-cbelsymu 263 9 and and CC cord-006252-cbelsymu 263 10 to to TO cord-006252-cbelsymu 263 11 evaluate evaluate VB cord-006252-cbelsymu 263 12 . . . cord-006252-cbelsymu 264 1 They -PRON- PRP cord-006252-cbelsymu 264 2 are be VBP cord-006252-cbelsymu 264 3 hard hard JJ cord-006252-cbelsymu 264 4 to to TO cord-006252-cbelsymu 264 5 conduct conduct VB cord-006252-cbelsymu 264 6 because because IN cord-006252-cbelsymu 264 7 randomisation randomisation NN cord-006252-cbelsymu 264 8 to to TO cord-006252-cbelsymu 264 9 control control VB cord-006252-cbelsymu 264 10 and and CC cord-006252-cbelsymu 264 11 vaccinated vaccinated JJ cord-006252-cbelsymu 264 12 groups group NNS cord-006252-cbelsymu 264 13 raises raise VBZ cord-006252-cbelsymu 264 14 ethical ethical JJ cord-006252-cbelsymu 264 15 questions question NNS cord-006252-cbelsymu 264 16 in in IN cord-006252-cbelsymu 264 17 high high JJ cord-006252-cbelsymu 264 18 risk risk NN cord-006252-cbelsymu 264 19 patients patient NNS cord-006252-cbelsymu 264 20 . . . cord-006252-cbelsymu 265 1 Evaluation evaluation NN cord-006252-cbelsymu 265 2 is be VBZ cord-006252-cbelsymu 265 3 difficult difficult JJ cord-006252-cbelsymu 265 4 because because IN cord-006252-cbelsymu 265 5 other other JJ cord-006252-cbelsymu 265 6 respiratory respiratory JJ cord-006252-cbelsymu 265 7 infectious infectious JJ cord-006252-cbelsymu 265 8 agents agent NNS cord-006252-cbelsymu 265 9 also also RB cord-006252-cbelsymu 265 10 cause cause VBP cord-006252-cbelsymu 265 11 colds cold NNS cord-006252-cbelsymu 265 12 , , , cord-006252-cbelsymu 265 13 pneumonia pneumonia NN cord-006252-cbelsymu 265 14 , , , cord-006252-cbelsymu 265 15 occasionally occasionally RB cord-006252-cbelsymu 265 16 death death NN cord-006252-cbelsymu 265 17 , , , cord-006252-cbelsymu 265 18 and and CC cord-006252-cbelsymu 265 19 often often RB cord-006252-cbelsymu 265 20 result result VBP cord-006252-cbelsymu 265 21 in in IN cord-006252-cbelsymu 265 22 hospitalisation hospitalisation NN cord-006252-cbelsymu 266 1 -the -the DT cord-006252-cbelsymu 266 2 criteria criterion NNS cord-006252-cbelsymu 266 3 used use VBD cord-006252-cbelsymu 266 4 to to TO cord-006252-cbelsymu 266 5 determine determine VB cord-006252-cbelsymu 266 6 efficacy efficacy NN cord-006252-cbelsymu 266 7 . . . cord-006252-cbelsymu 267 1 Vaccine vaccine NN cord-006252-cbelsymu 267 2 immunogenicity immunogenicity NN cord-006252-cbelsymu 267 3 and and CC cord-006252-cbelsymu 267 4 protective protective JJ cord-006252-cbelsymu 267 5 efficacy efficacy NN cord-006252-cbelsymu 267 6 in in IN cord-006252-cbelsymu 267 7 the the DT cord-006252-cbelsymu 267 8 elderly elderly JJ cord-006252-cbelsymu 267 9 have have VBP cord-006252-cbelsymu 267 10 had have VBN cord-006252-cbelsymu 267 11 mixed mix VBN cord-006252-cbelsymu 267 12 reviews review NNS cord-006252-cbelsymu 267 13 . . . cord-006252-cbelsymu 268 1 Immunogenicity Immunogenicity NNP cord-006252-cbelsymu 268 2 , , , cord-006252-cbelsymu 268 3 the the DT cord-006252-cbelsymu 268 4 vaccine vaccine NN cord-006252-cbelsymu 268 5 's 's POS cord-006252-cbelsymu 268 6 ability ability NN cord-006252-cbelsymu 268 7 to to TO cord-006252-cbelsymu 268 8 stimulate stimulate VB cord-006252-cbelsymu 268 9 protective protective JJ cord-006252-cbelsymu 268 10 levels level NNS cord-006252-cbelsymu 268 11 of of IN cord-006252-cbelsymu 268 12 antibody antibody NN cord-006252-cbelsymu 268 13 , , , cord-006252-cbelsymu 268 14 appears appear VBZ cord-006252-cbelsymu 268 15 to to TO cord-006252-cbelsymu 268 16 be be VB cord-006252-cbelsymu 268 17 adequate adequate JJ cord-006252-cbelsymu 268 18 in in IN cord-006252-cbelsymu 268 19 many many JJ cord-006252-cbelsymu 268 20 studies study NNS cord-006252-cbelsymu 268 21 . . . cord-006252-cbelsymu 269 1 Protective protective JJ cord-006252-cbelsymu 269 2 levels level NNS cord-006252-cbelsymu 269 3 of of IN cord-006252-cbelsymu 269 4 serum serum NN cord-006252-cbelsymu 269 5 antibody antibody NN cord-006252-cbelsymu 269 6 are be VBP cord-006252-cbelsymu 269 7 considered consider VBN cord-006252-cbelsymu 269 8 to to TO cord-006252-cbelsymu 269 9 be be VB cord-006252-cbelsymu 269 10 equal equal JJ cord-006252-cbelsymu 269 11 to to IN cord-006252-cbelsymu 269 12 or or CC cord-006252-cbelsymu 269 13 greater great JJR cord-006252-cbelsymu 269 14 than than IN cord-006252-cbelsymu 269 15 the the DT cord-006252-cbelsymu 269 16 reciprocal reciprocal NN cord-006252-cbelsymu 269 17 of of IN cord-006252-cbelsymu 269 18 serum serum NN cord-006252-cbelsymu 269 19 dilutions dilution NNS cord-006252-cbelsymu 269 20 at at IN cord-006252-cbelsymu 269 21 1 1 CD cord-006252-cbelsymu 269 22 : : SYM cord-006252-cbelsymu 269 23 32 32 CD cord-006252-cbelsymu 269 24 or or CC cord-006252-cbelsymu 269 25 1 1 CD cord-006252-cbelsymu 269 26 : : SYM cord-006252-cbelsymu 269 27 40 40 CD cord-006252-cbelsymu 269 28 , , , cord-006252-cbelsymu 269 29 depending depend VBG cord-006252-cbelsymu 269 30 on on IN cord-006252-cbelsymu 269 31 the the DT cord-006252-cbelsymu 269 32 dilution dilution NN cord-006252-cbelsymu 269 33 method method NN cord-006252-cbelsymu 269 34 . . . cord-006252-cbelsymu 270 1 Protective protective JJ cord-006252-cbelsymu 270 2 levels level NNS cord-006252-cbelsymu 270 3 are be VBP cord-006252-cbelsymu 270 4 usually usually RB cord-006252-cbelsymu 270 5 achieved achieve VBN cord-006252-cbelsymu 270 6 in in IN cord-006252-cbelsymu 270 7 70 70 CD cord-006252-cbelsymu 270 8 to to TO cord-006252-cbelsymu 270 9 90 90 CD cord-006252-cbelsymu 270 10 % % NN cord-006252-cbelsymu 270 11 of of IN cord-006252-cbelsymu 270 12 vaccine vaccine NN cord-006252-cbelsymu 270 13 recipients recipient NNS cord-006252-cbelsymu 270 14 . . . cord-006252-cbelsymu 271 1 reviewed review VBN cord-006252-cbelsymu 271 2 17 17 CD cord-006252-cbelsymu 271 3 papers paper NNS cord-006252-cbelsymu 271 4 on on IN cord-006252-cbelsymu 271 5 this this DT cord-006252-cbelsymu 271 6 subject subject NN cord-006252-cbelsymu 271 7 published publish VBN cord-006252-cbelsymu 271 8 between between IN cord-006252-cbelsymu 271 9 1968 1968 CD cord-006252-cbelsymu 271 10 and and CC cord-006252-cbelsymu 271 11 1988 1988 CD cord-006252-cbelsymu 271 12 . . . cord-006252-cbelsymu 272 1 A a DT cord-006252-cbelsymu 272 2 total total JJ cord-006252-cbelsymu 272 3 Drugs drug NNS cord-006252-cbelsymu 272 4 & & CC cord-006252-cbelsymu 272 5 Aging Aging NNP cord-006252-cbelsymu 272 6 1 1 CD cord-006252-cbelsymu 272 7 ( ( -LRB- cord-006252-cbelsymu 272 8 6 6 CD cord-006252-cbelsymu 272 9 ) ) -RRB- cord-006252-cbelsymu 272 10 1991 1991 CD cord-006252-cbelsymu 272 11 of of IN cord-006252-cbelsymu 272 12 30 30 CD cord-006252-cbelsymu 272 13 comparisons comparison NNS cord-006252-cbelsymu 272 14 were be VBD cord-006252-cbelsymu 272 15 available available JJ cord-006252-cbelsymu 272 16 in in IN cord-006252-cbelsymu 272 17 the the DT cord-006252-cbelsymu 272 18 17 17 CD cord-006252-cbelsymu 272 19 papers paper NNS cord-006252-cbelsymu 272 20 . . . cord-006252-cbelsymu 273 1 In in IN cord-006252-cbelsymu 273 2 10 10 CD cord-006252-cbelsymu 273 3 , , , cord-006252-cbelsymu 273 4 the the DT cord-006252-cbelsymu 273 5 immune immune JJ cord-006252-cbelsymu 273 6 response response NN cord-006252-cbelsymu 273 7 was be VBD cord-006252-cbelsymu 273 8 superior superior JJ cord-006252-cbelsymu 273 9 in in IN cord-006252-cbelsymu 273 10 young young JJ cord-006252-cbelsymu 273 11 subjects subject NNS cord-006252-cbelsymu 273 12 ; ; : cord-006252-cbelsymu 273 13 in in IN cord-006252-cbelsymu 273 14 4 4 CD cord-006252-cbelsymu 273 15 , , , cord-006252-cbelsymu 273 16 the the DT cord-006252-cbelsymu 273 17 elderly elderly JJ cord-006252-cbelsymu 273 18 responded respond VBD cord-006252-cbelsymu 273 19 better well RBR cord-006252-cbelsymu 273 20 , , , cord-006252-cbelsymu 273 21 and and CC cord-006252-cbelsymu 273 22 in in IN cord-006252-cbelsymu 273 23 16 16 CD cord-006252-cbelsymu 273 24 , , , cord-006252-cbelsymu 273 25 no no DT cord-006252-cbelsymu 273 26 significant significant JJ cord-006252-cbelsymu 273 27 difference difference NN cord-006252-cbelsymu 273 28 was be VBD cord-006252-cbelsymu 273 29 noted note VBN cord-006252-cbelsymu 273 30 between between IN cord-006252-cbelsymu 273 31 the the DT cord-006252-cbelsymu 273 32 young young JJ cord-006252-cbelsymu 273 33 and and CC cord-006252-cbelsymu 273 34 old old JJ cord-006252-cbelsymu 273 35 subjects subject NNS cord-006252-cbelsymu 273 36 ; ; : cord-006252-cbelsymu 273 37 in in IN cord-006252-cbelsymu 273 38 this this DT cord-006252-cbelsymu 273 39 instance instance NN cord-006252-cbelsymu 273 40 , , , cord-006252-cbelsymu 273 41 the the DT cord-006252-cbelsymu 273 42 lack lack NN cord-006252-cbelsymu 273 43 of of IN cord-006252-cbelsymu 273 44 differences difference NNS cord-006252-cbelsymu 273 45 may may MD cord-006252-cbelsymu 273 46 have have VB cord-006252-cbelsymu 273 47 been be VBN cord-006252-cbelsymu 273 48 due due JJ cord-006252-cbelsymu 273 49 to to IN cord-006252-cbelsymu 273 50 a a DT cord-006252-cbelsymu 273 51 type type NN cord-006252-cbelsymu 273 52 2 2 CD cord-006252-cbelsymu 273 53 error error NN cord-006252-cbelsymu 273 54 because because IN cord-006252-cbelsymu 273 55 the the DT cord-006252-cbelsymu 273 56 numbers number NNS cord-006252-cbelsymu 273 57 studied study VBN cord-006252-cbelsymu 273 58 were be VBD cord-006252-cbelsymu 273 59 low low JJ cord-006252-cbelsymu 273 60 . . . cord-006252-cbelsymu 274 1 pointed point VBD cord-006252-cbelsymu 274 2 out out RP cord-006252-cbelsymu 274 3 3 3 CD cord-006252-cbelsymu 274 4 methodological methodological JJ cord-006252-cbelsymu 274 5 limitations limitation NNS cord-006252-cbelsymu 274 6 . . . cord-006252-cbelsymu 275 1 The the DT cord-006252-cbelsymu 275 2 studies study NNS cord-006252-cbelsymu 275 3 included include VBD cord-006252-cbelsymu 275 4 , , , cord-006252-cbelsymu 275 5 firstly firstly RB cord-006252-cbelsymu 275 6 , , , cord-006252-cbelsymu 275 7 subjects subject NNS cord-006252-cbelsymu 275 8 with with IN cord-006252-cbelsymu 275 9 illnesses illness NNS cord-006252-cbelsymu 275 10 or or CC cord-006252-cbelsymu 275 11 taking take VBG cord-006252-cbelsymu 275 12 drugs drug NNS cord-006252-cbelsymu 275 13 , , , cord-006252-cbelsymu 275 14 which which WDT cord-006252-cbelsymu 275 15 affect affect VBP cord-006252-cbelsymu 275 16 the the DT cord-006252-cbelsymu 275 17 immune immune JJ cord-006252-cbelsymu 275 18 system system NN cord-006252-cbelsymu 275 19 ; ; : cord-006252-cbelsymu 275 20 secondly secondly RB cord-006252-cbelsymu 275 21 , , , cord-006252-cbelsymu 275 22 patients patient NNS cord-006252-cbelsymu 275 23 immunised immunise VBD cord-006252-cbelsymu 275 24 previously previously RB cord-006252-cbelsymu 275 25 with with IN cord-006252-cbelsymu 275 26 influenza influenza NN cord-006252-cbelsymu 275 27 vaccine vaccine NN cord-006252-cbelsymu 275 28 ; ; : cord-006252-cbelsymu 275 29 and and CC cord-006252-cbelsymu 275 30 finally finally RB cord-006252-cbelsymu 275 31 , , , cord-006252-cbelsymu 275 32 those those DT cord-006252-cbelsymu 275 33 with with IN cord-006252-cbelsymu 275 34 protective protective JJ cord-006252-cbelsymu 275 35 antibody antibody NN cord-006252-cbelsymu 275 36 levels level NNS cord-006252-cbelsymu 275 37 before before IN cord-006252-cbelsymu 275 38 immunisation immunisation NN cord-006252-cbelsymu 275 39 . . . cord-006252-cbelsymu 276 1 Inclusion inclusion NN cord-006252-cbelsymu 276 2 of of IN cord-006252-cbelsymu 276 3 patients patient NNS cord-006252-cbelsymu 276 4 with with IN cord-006252-cbelsymu 276 5 any any DT cord-006252-cbelsymu 276 6 of of IN cord-006252-cbelsymu 276 7 these these DT cord-006252-cbelsymu 276 8 3 3 CD cord-006252-cbelsymu 276 9 factors factor NNS cord-006252-cbelsymu 276 10 would would MD cord-006252-cbelsymu 276 11 tend tend VB cord-006252-cbelsymu 276 12 to to TO cord-006252-cbelsymu 276 13 underestimate underestimate VB cord-006252-cbelsymu 276 14 the the DT cord-006252-cbelsymu 276 15 ability ability NN cord-006252-cbelsymu 276 16 of of IN cord-006252-cbelsymu 276 17 elderly elderly JJ cord-006252-cbelsymu 276 18 subjects subject NNS cord-006252-cbelsymu 276 19 to to TO cord-006252-cbelsymu 276 20 respond respond VB cord-006252-cbelsymu 276 21 to to IN cord-006252-cbelsymu 276 22 immunisation immunisation NN cord-006252-cbelsymu 276 23 . . . cord-006252-cbelsymu 277 1 The the DT cord-006252-cbelsymu 277 2 association association NN cord-006252-cbelsymu 277 3 between between IN cord-006252-cbelsymu 277 4 increasing increase VBG cord-006252-cbelsymu 277 5 age age NN cord-006252-cbelsymu 277 6 and and CC cord-006252-cbelsymu 277 7 a a DT cord-006252-cbelsymu 277 8 poor poor JJ cord-006252-cbelsymu 277 9 immune immune JJ cord-006252-cbelsymu 277 10 response response NN cord-006252-cbelsymu 277 11 to to IN cord-006252-cbelsymu 277 12 influenza influenza NN cord-006252-cbelsymu 277 13 vaccine vaccine NN cord-006252-cbelsymu 277 14 has have VBZ cord-006252-cbelsymu 277 15 thus thus RB cord-006252-cbelsymu 277 16 not not RB cord-006252-cbelsymu 277 17 yet yet RB cord-006252-cbelsymu 277 18 been be VBN cord-006252-cbelsymu 277 19 convincingly convincingly RB cord-006252-cbelsymu 277 20 made make VBN cord-006252-cbelsymu 277 21 . . . cord-006252-cbelsymu 278 1 Perhaps perhaps RB cord-006252-cbelsymu 278 2 a a DT cord-006252-cbelsymu 278 3 small small JJ cord-006252-cbelsymu 278 4 subgroup subgroup NN cord-006252-cbelsymu 278 5 of of IN cord-006252-cbelsymu 278 6 the the DT cord-006252-cbelsymu 278 7 elderly elderly JJ cord-006252-cbelsymu 278 8 population population NN cord-006252-cbelsymu 278 9 respond respond VBP cord-006252-cbelsymu 278 10 poorly poorly RB cord-006252-cbelsymu 278 11 while while IN cord-006252-cbelsymu 278 12 most most JJS cord-006252-cbelsymu 278 13 respond respond VBP cord-006252-cbelsymu 278 14 normally normally RB cord-006252-cbelsymu 278 15 . . . cord-006252-cbelsymu 279 1 This this DT cord-006252-cbelsymu 279 2 was be VBD cord-006252-cbelsymu 279 3 originally originally RB cord-006252-cbelsymu 279 4 suggested suggest VBN cord-006252-cbelsymu 279 5 in in IN cord-006252-cbelsymu 279 6 a a DT cord-006252-cbelsymu 279 7 study study NN cord-006252-cbelsymu 279 8 by by IN cord-006252-cbelsymu 279 9 Phair Phair NNP cord-006252-cbelsymu 279 10 et et NNP cord-006252-cbelsymu 279 11 al al NNP cord-006252-cbelsymu 279 12 . . . cord-006252-cbelsymu 280 1 ( ( -LRB- cord-006252-cbelsymu 280 2 1978 1978 CD cord-006252-cbelsymu 280 3 ) ) -RRB- cord-006252-cbelsymu 280 4 examining examine VBG cord-006252-cbelsymu 280 5 the the DT cord-006252-cbelsymu 280 6 T T NNP cord-006252-cbelsymu 280 7 cell cell NN cord-006252-cbelsymu 280 8 response response NN cord-006252-cbelsymu 280 9 of of IN cord-006252-cbelsymu 280 10 infirm infirm JJ cord-006252-cbelsymu 280 11 elderly elderly JJ cord-006252-cbelsymu 280 12 to to TO cord-006252-cbelsymu 280 13 influenza influenza NN cord-006252-cbelsymu 280 14 antigens antigen NNS cord-006252-cbelsymu 280 15 . . . cord-006252-cbelsymu 281 1 More more RBR cord-006252-cbelsymu 281 2 recently recently RB cord-006252-cbelsymu 281 3 , , , cord-006252-cbelsymu 281 4 in in IN cord-006252-cbelsymu 281 5 a a DT cord-006252-cbelsymu 281 6 study study NN cord-006252-cbelsymu 281 7 by by IN cord-006252-cbelsymu 281 8 , , , cord-006252-cbelsymu 281 9 bedridden bedridden JJ cord-006252-cbelsymu 281 10 , , , cord-006252-cbelsymu 281 11 infirm infirm JJ cord-006252-cbelsymu 281 12 elderly elderly JJ cord-006252-cbelsymu 281 13 patients patient NNS cord-006252-cbelsymu 281 14 appeared appear VBD cord-006252-cbelsymu 281 15 to to TO cord-006252-cbelsymu 281 16 respond respond VB cord-006252-cbelsymu 281 17 less less RBR cord-006252-cbelsymu 281 18 well well RB cord-006252-cbelsymu 281 19 to to IN cord-006252-cbelsymu 281 20 influenza influenza NN cord-006252-cbelsymu 281 21 vaccine vaccine NN cord-006252-cbelsymu 281 22 than than IN cord-006252-cbelsymu 281 23 did do VBD cord-006252-cbelsymu 281 24 healthy healthy JJ cord-006252-cbelsymu 281 25 , , , cord-006252-cbelsymu 281 26 ambulatory ambulatory JJ cord-006252-cbelsymu 281 27 elderly elderly JJ cord-006252-cbelsymu 281 28 patients patient NNS cord-006252-cbelsymu 281 29 . . . cord-006252-cbelsymu 282 1 Alternative alternative JJ cord-006252-cbelsymu 282 2 approaches approach NNS cord-006252-cbelsymu 282 3 to to IN cord-006252-cbelsymu 282 4 the the DT cord-006252-cbelsymu 282 5 standard standard JJ cord-006252-cbelsymu 282 6 immunisation immunisation NN cord-006252-cbelsymu 282 7 have have VBP cord-006252-cbelsymu 282 8 been be VBN cord-006252-cbelsymu 282 9 tried try VBN cord-006252-cbelsymu 282 10 . . . cord-006252-cbelsymu 283 1 Two two CD cord-006252-cbelsymu 283 2 doses dose NNS cord-006252-cbelsymu 283 3 1 1 CD cord-006252-cbelsymu 283 4 month month NN cord-006252-cbelsymu 283 5 apart apart RB cord-006252-cbelsymu 283 6 did do VBD cord-006252-cbelsymu 283 7 not not RB cord-006252-cbelsymu 283 8 improve improve VB cord-006252-cbelsymu 283 9 the the DT cord-006252-cbelsymu 283 10 immune immune JJ cord-006252-cbelsymu 283 11 response response NN cord-006252-cbelsymu 283 12 , , , cord-006252-cbelsymu 283 13 neither neither CC cord-006252-cbelsymu 283 14 did do VBD cord-006252-cbelsymu 283 15 2 2 CD cord-006252-cbelsymu 283 16 and and CC cord-006252-cbelsymu 283 17 3 3 CD cord-006252-cbelsymu 283 18 times time NNS cord-006252-cbelsymu 283 19 the the DT cord-006252-cbelsymu 283 20 standard standard JJ cord-006252-cbelsymu 283 21 dose dose NN cord-006252-cbelsymu 283 22 . . . cord-006252-cbelsymu 284 1 From from IN cord-006252-cbelsymu 284 2 currently currently RB cord-006252-cbelsymu 284 3 available available JJ cord-006252-cbelsymu 284 4 information information NN cord-006252-cbelsymu 284 5 we -PRON- PRP cord-006252-cbelsymu 284 6 can can MD cord-006252-cbelsymu 284 7 conclude conclude VB cord-006252-cbelsymu 284 8 that that IN cord-006252-cbelsymu 284 9 the the DT cord-006252-cbelsymu 284 10 recommended recommend VBN cord-006252-cbelsymu 284 11 single single JJ cord-006252-cbelsymu 284 12 standard standard JJ cord-006252-cbelsymu 284 13 dose dose NN cord-006252-cbelsymu 284 14 of of IN cord-006252-cbelsymu 284 15 killed kill VBN cord-006252-cbelsymu 284 16 influenza influenza NN cord-006252-cbelsymu 284 17 vaccine vaccine NN cord-006252-cbelsymu 284 18 will will MD cord-006252-cbelsymu 284 19 stimulate stimulate VB cord-006252-cbelsymu 284 20 an an DT cord-006252-cbelsymu 284 21 adequate adequate JJ cord-006252-cbelsymu 284 22 immune immune JJ cord-006252-cbelsymu 284 23 response response NN cord-006252-cbelsymu 284 24 in in IN cord-006252-cbelsymu 284 25 most most JJS cord-006252-cbelsymu 284 26 elderly elderly JJ cord-006252-cbelsymu 284 27 persons person NNS cord-006252-cbelsymu 284 28 . . . cord-006252-cbelsymu 285 1 Finally finally RB cord-006252-cbelsymu 285 2 , , , cord-006252-cbelsymu 285 3 and and CC cord-006252-cbelsymu 285 4 most most RBS cord-006252-cbelsymu 285 5 importantly importantly RB cord-006252-cbelsymu 285 6 , , , cord-006252-cbelsymu 285 7 in in IN cord-006252-cbelsymu 285 8 a a DT cord-006252-cbelsymu 285 9 number number NN cord-006252-cbelsymu 285 10 of of IN cord-006252-cbelsymu 285 11 recent recent JJ cord-006252-cbelsymu 285 12 studies study NNS cord-006252-cbelsymu 285 13 influenza influenza NN cord-006252-cbelsymu 285 14 vaccine vaccine NN cord-006252-cbelsymu 285 15 has have VBZ cord-006252-cbelsymu 285 16 been be VBN cord-006252-cbelsymu 285 17 shown show VBN cord-006252-cbelsymu 285 18 to to TO cord-006252-cbelsymu 285 19 reduce reduce VB cord-006252-cbelsymu 285 20 mortality mortality NN cord-006252-cbelsymu 285 21 from from IN cord-006252-cbelsymu 285 22 influenza influenza NN cord-006252-cbelsymu 285 23 virus virus NN cord-006252-cbelsymu 285 24 infection infection NN cord-006252-cbelsymu 285 25 Gross Gross NNP cord-006252-cbelsymu 285 26 et et FW cord-006252-cbelsymu 285 27 al al NNP cord-006252-cbelsymu 285 28 . . NNP cord-006252-cbelsymu 285 29 1988a 1988a CD cord-006252-cbelsymu 285 30 ) ) -RRB- cord-006252-cbelsymu 285 31 . . . cord-006252-cbelsymu 286 1 Recent recent JJ cord-006252-cbelsymu 286 2 studies study NNS cord-006252-cbelsymu 286 3 on on IN cord-006252-cbelsymu 286 4 the the DT cord-006252-cbelsymu 286 5 adverse adverse JJ cord-006252-cbelsymu 286 6 effects effect NNS cord-006252-cbelsymu 286 7 of of IN cord-006252-cbelsymu 286 8 influenza influenza NN cord-006252-cbelsymu 286 9 vaccine vaccine NN cord-006252-cbelsymu 286 10 show show VBP cord-006252-cbelsymu 286 11 that that IN cord-006252-cbelsymu 286 12 the the DT cord-006252-cbelsymu 286 13 vaccine vaccine NN cord-006252-cbelsymu 286 14 is be VBZ cord-006252-cbelsymu 286 15 typically typically RB cord-006252-cbelsymu 286 16 well well RB cord-006252-cbelsymu 286 17 436 436 CD cord-006252-cbelsymu 286 18 ics ic NNS cord-006252-cbelsymu 286 19 at at IN cord-006252-cbelsymu 286 20 any any DT cord-006252-cbelsymu 286 21 time time NN cord-006252-cbelsymu 286 22 of of IN cord-006252-cbelsymu 286 23 the the DT cord-006252-cbelsymu 286 24 year year NN cord-006252-cbelsymu 286 25 or or CC cord-006252-cbelsymu 286 26 from from IN cord-006252-cbelsymu 286 27 the the DT cord-006252-cbelsymu 286 28 Southern Southern NNP cord-006252-cbelsymu 286 29 to to IN cord-006252-cbelsymu 286 30 the the DT cord-006252-cbelsymu 286 31 Northern Northern NNP cord-006252-cbelsymu 286 32 Hemisphere Hemisphere NNP cord-006252-cbelsymu 286 33 between between IN cord-006252-cbelsymu 286 34 August August NNP cord-006252-cbelsymu 286 35 and and CC cord-006252-cbelsymu 286 36 March March NNP cord-006252-cbelsymu 286 37 and and CC cord-006252-cbelsymu 286 38 the the DT cord-006252-cbelsymu 286 39 Northern Northern NNP cord-006252-cbelsymu 286 40 to to IN cord-006252-cbelsymu 286 41 the the DT cord-006252-cbelsymu 286 42 Southern Southern NNP cord-006252-cbelsymu 286 43 Hemisphere Hemisphere NNP cord-006252-cbelsymu 286 44 between between IN cord-006252-cbelsymu 286 45 April April NNP cord-006252-cbelsymu 286 46 and and CC cord-006252-cbelsymu 286 47 September September NNP cord-006252-cbelsymu 286 48 . . . cord-006252-cbelsymu 287 1 The the DT cord-006252-cbelsymu 287 2 vaccine vaccine NN cord-006252-cbelsymu 287 3 is be VBZ cord-006252-cbelsymu 287 4 contraindicated contraindicate VBN cord-006252-cbelsymu 287 5 in in IN cord-006252-cbelsymu 287 6 persons person NNS cord-006252-cbelsymu 287 7 with with IN cord-006252-cbelsymu 287 8 anaphylaxis anaphylaxis NN cord-006252-cbelsymu 287 9 to to IN cord-006252-cbelsymu 287 10 eggs egg NNS cord-006252-cbelsymu 287 11 and and CC cord-006252-cbelsymu 287 12 in in IN cord-006252-cbelsymu 287 13 those those DT cord-006252-cbelsymu 287 14 with with IN cord-006252-cbelsymu 287 15 an an DT cord-006252-cbelsymu 287 16 acute acute JJ cord-006252-cbelsymu 287 17 febrile febrile JJ cord-006252-cbelsymu 287 18 illness illness NN cord-006252-cbelsymu 287 19 . . . cord-006252-cbelsymu 288 1 A a DT cord-006252-cbelsymu 288 2 protocol protocol NN cord-006252-cbelsymu 288 3 is be VBZ cord-006252-cbelsymu 288 4 available available JJ cord-006252-cbelsymu 288 5 for for IN cord-006252-cbelsymu 288 6 giving give VBG cord-006252-cbelsymu 288 7 vaccine vaccine NN cord-006252-cbelsymu 288 8 to to IN cord-006252-cbelsymu 288 9 allergic allergic JJ cord-006252-cbelsymu 288 10 patients patient NNS cord-006252-cbelsymu 288 11 at at IN cord-006252-cbelsymu 288 12 high high JJ cord-006252-cbelsymu 288 13 risk risk NN cord-006252-cbelsymu 288 14 of of IN cord-006252-cbelsymu 288 15 influenza influenza NN cord-006252-cbelsymu 288 16 complications complication NNS cord-006252-cbelsymu 288 17 ( ( -LRB- cord-006252-cbelsymu 288 18 Recommendations Recommendations NNPS cord-006252-cbelsymu 288 19 of of IN cord-006252-cbelsymu 288 20 the the DT cord-006252-cbelsymu 288 21 Immunization Immunization NNP cord-006252-cbelsymu 288 22 Practices Practices NNPS cord-006252-cbelsymu 288 23 Advisory Advisory NNP cord-006252-cbelsymu 288 24 Committee Committee NNP cord-006252-cbelsymu 288 25 1990 1990 CD cord-006252-cbelsymu 288 26 ) ) -RRB- cord-006252-cbelsymu 288 27 . . . cord-006252-cbelsymu 289 1 Other other JJ cord-006252-cbelsymu 289 2 vaccines vaccine NNS cord-006252-cbelsymu 289 3 can can MD cord-006252-cbelsymu 289 4 be be VB cord-006252-cbelsymu 289 5 given give VBN cord-006252-cbelsymu 289 6 along along RP cord-006252-cbelsymu 289 7 with with IN cord-006252-cbelsymu 289 8 influenza influenza NN cord-006252-cbelsymu 289 9 vaccine vaccine NN cord-006252-cbelsymu 289 10 , , , cord-006252-cbelsymu 289 11 such such JJ cord-006252-cbelsymu 289 12 as as IN cord-006252-cbelsymu 289 13 pneumococcal pneumococcal JJ cord-006252-cbelsymu 289 14 , , , cord-006252-cbelsymu 289 15 measlesmumps measlesmumps NN cord-006252-cbelsymu 289 16 - - HYPH cord-006252-cbelsymu 289 17 rubella rubella NN cord-006252-cbelsymu 289 18 , , , cord-006252-cbelsymu 289 19 Haemophilus Haemophilus NNP cord-006252-cbelsymu 289 20 injluenzae injluenzae NN cord-006252-cbelsymu 289 21 type type NN cord-006252-cbelsymu 289 22 b b NN cord-006252-cbelsymu 289 23 , , , cord-006252-cbelsymu 289 24 and and CC cord-006252-cbelsymu 289 25 oral oral JJ cord-006252-cbelsymu 289 26 polio polio NN cord-006252-cbelsymu 289 27 vaccines vaccine NNS cord-006252-cbelsymu 289 28 . . . cord-006252-cbelsymu 290 1 Pertussis pertussis NN cord-006252-cbelsymu 290 2 vaccine vaccine NN cord-006252-cbelsymu 290 3 , , , cord-006252-cbelsymu 290 4 however however RB cord-006252-cbelsymu 290 5 , , , cord-006252-cbelsymu 290 6 should should MD cord-006252-cbelsymu 290 7 not not RB cord-006252-cbelsymu 290 8 be be VB cord-006252-cbelsymu 290 9 given give VBN cord-006252-cbelsymu 290 10 within within IN cord-006252-cbelsymu 290 11 3 3 CD cord-006252-cbelsymu 290 12 days day NNS cord-006252-cbelsymu 290 13 of of IN cord-006252-cbelsymu 290 14 influenza influenza NN cord-006252-cbelsymu 290 15 virus virus NN cord-006252-cbelsymu 290 16 vaccine vaccine NN cord-006252-cbelsymu 290 17 . . . cord-006252-cbelsymu 291 1 For for IN cord-006252-cbelsymu 291 2 optimal optimal JJ cord-006252-cbelsymu 291 3 effect effect NN cord-006252-cbelsymu 291 4 , , , cord-006252-cbelsymu 291 5 the the DT cord-006252-cbelsymu 291 6 vaccine vaccine NN cord-006252-cbelsymu 291 7 should should MD cord-006252-cbelsymu 291 8 be be VB cord-006252-cbelsymu 291 9 given give VBN cord-006252-cbelsymu 291 10 in in IN cord-006252-cbelsymu 291 11 November November NNP cord-006252-cbelsymu 291 12 in in IN cord-006252-cbelsymu 291 13 the the DT cord-006252-cbelsymu 291 14 Northern Northern NNP cord-006252-cbelsymu 291 15 Hemisphere Hemisphere NNP cord-006252-cbelsymu 291 16 or or CC cord-006252-cbelsymu 291 17 May May NNP cord-006252-cbelsymu 291 18 in in IN cord-006252-cbelsymu 291 19 the the DT cord-006252-cbelsymu 291 20 Southern Southern NNP cord-006252-cbelsymu 291 21 Hemisphere Hemisphere NNP cord-006252-cbelsymu 291 22 , , , cord-006252-cbelsymu 291 23 before before IN cord-006252-cbelsymu 291 24 the the DT cord-006252-cbelsymu 291 25 winter winter NN cord-006252-cbelsymu 291 26 influenza influenza NN cord-006252-cbelsymu 291 27 season season NN cord-006252-cbelsymu 291 28 begins begin VBZ cord-006252-cbelsymu 291 29 . . . cord-006252-cbelsymu 292 1 Effective effective JJ cord-006252-cbelsymu 292 2 antibody antibody NN cord-006252-cbelsymu 292 3 levels level NNS cord-006252-cbelsymu 292 4 develop develop VBP cord-006252-cbelsymu 292 5 within within IN cord-006252-cbelsymu 292 6 2 2 CD cord-006252-cbelsymu 292 7 weeks week NNS cord-006252-cbelsymu 292 8 in in IN cord-006252-cbelsymu 292 9 most most RBS cord-006252-cbelsymu 292 10 previously previously RB cord-006252-cbelsymu 292 11 immunised immunise VBN cord-006252-cbelsymu 292 12 persons person NNS cord-006252-cbelsymu 292 13 . . . cord-006252-cbelsymu 293 1 The the DT cord-006252-cbelsymu 293 2 levels level NNS cord-006252-cbelsymu 293 3 decline decline VBP cord-006252-cbelsymu 293 4 a a DT cord-006252-cbelsymu 293 5 few few JJ cord-006252-cbelsymu 293 6 months month NNS cord-006252-cbelsymu 293 7 later later RB cord-006252-cbelsymu 293 8 , , , cord-006252-cbelsymu 293 9 when when WRB cord-006252-cbelsymu 293 10 they -PRON- PRP cord-006252-cbelsymu 293 11 may may MD cord-006252-cbelsymu 293 12 be be VB cord-006252-cbelsymu 293 13 suboptimal suboptimal JJ cord-006252-cbelsymu 293 14 . . . cord-006252-cbelsymu 294 1 Studies study NNS cord-006252-cbelsymu 294 2 investigating investigate VBG cord-006252-cbelsymu 294 3 vaccine vaccine NN cord-006252-cbelsymu 294 4 efficacy efficacy NN cord-006252-cbelsymu 294 5 are be VBP cord-006252-cbelsymu 294 6 difficult difficult JJ cord-006252-cbelsymu 294 7 to to TO cord-006252-cbelsymu 294 8 conduct conduct VB cord-006252-cbelsymu 294 9 and and CC cord-006252-cbelsymu 294 10 to to TO cord-006252-cbelsymu 294 11 evaluate evaluate VB cord-006252-cbelsymu 294 12 . . . cord-006252-cbelsymu 295 1 They -PRON- PRP cord-006252-cbelsymu 295 2 are be VBP cord-006252-cbelsymu 295 3 hard hard JJ cord-006252-cbelsymu 295 4 to to TO cord-006252-cbelsymu 295 5 conduct conduct VB cord-006252-cbelsymu 295 6 because because IN cord-006252-cbelsymu 295 7 randomisation randomisation NN cord-006252-cbelsymu 295 8 to to TO cord-006252-cbelsymu 295 9 control control VB cord-006252-cbelsymu 295 10 and and CC cord-006252-cbelsymu 295 11 vaccinated vaccinated JJ cord-006252-cbelsymu 295 12 groups group NNS cord-006252-cbelsymu 295 13 raises raise VBZ cord-006252-cbelsymu 295 14 ethical ethical JJ cord-006252-cbelsymu 295 15 questions question NNS cord-006252-cbelsymu 295 16 in in IN cord-006252-cbelsymu 295 17 high high JJ cord-006252-cbelsymu 295 18 risk risk NN cord-006252-cbelsymu 295 19 patients patient NNS cord-006252-cbelsymu 295 20 . . . cord-006252-cbelsymu 296 1 Evaluation evaluation NN cord-006252-cbelsymu 296 2 is be VBZ cord-006252-cbelsymu 296 3 difficult difficult JJ cord-006252-cbelsymu 296 4 because because IN cord-006252-cbelsymu 296 5 other other JJ cord-006252-cbelsymu 296 6 respiratory respiratory JJ cord-006252-cbelsymu 296 7 infectious infectious JJ cord-006252-cbelsymu 296 8 agents agent NNS cord-006252-cbelsymu 296 9 also also RB cord-006252-cbelsymu 296 10 cause cause VBP cord-006252-cbelsymu 296 11 colds cold NNS cord-006252-cbelsymu 296 12 , , , cord-006252-cbelsymu 296 13 pneumonia pneumonia NN cord-006252-cbelsymu 296 14 , , , cord-006252-cbelsymu 296 15 occasionally occasionally RB cord-006252-cbelsymu 296 16 death death NN cord-006252-cbelsymu 296 17 , , , cord-006252-cbelsymu 296 18 and and CC cord-006252-cbelsymu 296 19 often often RB cord-006252-cbelsymu 296 20 result result VBP cord-006252-cbelsymu 296 21 in in IN cord-006252-cbelsymu 296 22 hospitalisation hospitalisation NN cord-006252-cbelsymu 297 1 -the -the DT cord-006252-cbelsymu 297 2 criteria criterion NNS cord-006252-cbelsymu 297 3 used use VBD cord-006252-cbelsymu 297 4 to to TO cord-006252-cbelsymu 297 5 determine determine VB cord-006252-cbelsymu 297 6 efficacy efficacy NN cord-006252-cbelsymu 297 7 . . . cord-006252-cbelsymu 298 1 Vaccine vaccine NN cord-006252-cbelsymu 298 2 immunogenicity immunogenicity NN cord-006252-cbelsymu 298 3 and and CC cord-006252-cbelsymu 298 4 protective protective JJ cord-006252-cbelsymu 298 5 efficacy efficacy NN cord-006252-cbelsymu 298 6 in in IN cord-006252-cbelsymu 298 7 the the DT cord-006252-cbelsymu 298 8 elderly elderly JJ cord-006252-cbelsymu 298 9 have have VBP cord-006252-cbelsymu 298 10 had have VBN cord-006252-cbelsymu 298 11 mixed mix VBN cord-006252-cbelsymu 298 12 reviews review NNS cord-006252-cbelsymu 298 13 . . . cord-006252-cbelsymu 299 1 Immunogenicity Immunogenicity NNP cord-006252-cbelsymu 299 2 , , , cord-006252-cbelsymu 299 3 the the DT cord-006252-cbelsymu 299 4 vaccine vaccine NN cord-006252-cbelsymu 299 5 's 's POS cord-006252-cbelsymu 299 6 ability ability NN cord-006252-cbelsymu 299 7 to to TO cord-006252-cbelsymu 299 8 stimulate stimulate VB cord-006252-cbelsymu 299 9 protective protective JJ cord-006252-cbelsymu 299 10 levels level NNS cord-006252-cbelsymu 299 11 of of IN cord-006252-cbelsymu 299 12 antibody antibody NN cord-006252-cbelsymu 299 13 , , , cord-006252-cbelsymu 299 14 appears appear VBZ cord-006252-cbelsymu 299 15 to to TO cord-006252-cbelsymu 299 16 be be VB cord-006252-cbelsymu 299 17 adequate adequate JJ cord-006252-cbelsymu 299 18 in in IN cord-006252-cbelsymu 299 19 many many JJ cord-006252-cbelsymu 299 20 studies study NNS cord-006252-cbelsymu 299 21 . . . cord-006252-cbelsymu 300 1 Protective protective JJ cord-006252-cbelsymu 300 2 levels level NNS cord-006252-cbelsymu 300 3 of of IN cord-006252-cbelsymu 300 4 serum serum NN cord-006252-cbelsymu 300 5 antibody antibody NN cord-006252-cbelsymu 300 6 are be VBP cord-006252-cbelsymu 300 7 considered consider VBN cord-006252-cbelsymu 300 8 to to TO cord-006252-cbelsymu 300 9 be be VB cord-006252-cbelsymu 300 10 equal equal JJ cord-006252-cbelsymu 300 11 to to IN cord-006252-cbelsymu 300 12 or or CC cord-006252-cbelsymu 300 13 greater great JJR cord-006252-cbelsymu 300 14 than than IN cord-006252-cbelsymu 300 15 the the DT cord-006252-cbelsymu 300 16 reciprocal reciprocal NN cord-006252-cbelsymu 300 17 of of IN cord-006252-cbelsymu 300 18 serum serum NN cord-006252-cbelsymu 300 19 dilutions dilution NNS cord-006252-cbelsymu 300 20 at at IN cord-006252-cbelsymu 300 21 1 1 CD cord-006252-cbelsymu 300 22 : : SYM cord-006252-cbelsymu 300 23 32 32 CD cord-006252-cbelsymu 300 24 or or CC cord-006252-cbelsymu 300 25 1 1 CD cord-006252-cbelsymu 300 26 : : SYM cord-006252-cbelsymu 300 27 40 40 CD cord-006252-cbelsymu 300 28 , , , cord-006252-cbelsymu 300 29 depending depend VBG cord-006252-cbelsymu 300 30 on on IN cord-006252-cbelsymu 300 31 the the DT cord-006252-cbelsymu 300 32 dilution dilution NN cord-006252-cbelsymu 300 33 method method NN cord-006252-cbelsymu 300 34 . . . cord-006252-cbelsymu 301 1 Protective protective JJ cord-006252-cbelsymu 301 2 levels level NNS cord-006252-cbelsymu 301 3 are be VBP cord-006252-cbelsymu 301 4 usually usually RB cord-006252-cbelsymu 301 5 achieved achieve VBN cord-006252-cbelsymu 301 6 in in IN cord-006252-cbelsymu 301 7 70 70 CD cord-006252-cbelsymu 301 8 to to TO cord-006252-cbelsymu 301 9 90 90 CD cord-006252-cbelsymu 301 10 % % NN cord-006252-cbelsymu 301 11 of of IN cord-006252-cbelsymu 301 12 vaccine vaccine NN cord-006252-cbelsymu 301 13 recipients recipient NNS cord-006252-cbelsymu 301 14 . . . cord-006252-cbelsymu 302 1 reviewed review VBN cord-006252-cbelsymu 302 2 17 17 CD cord-006252-cbelsymu 302 3 papers paper NNS cord-006252-cbelsymu 302 4 on on IN cord-006252-cbelsymu 302 5 this this DT cord-006252-cbelsymu 302 6 subject subject NN cord-006252-cbelsymu 302 7 published publish VBN cord-006252-cbelsymu 302 8 between between IN cord-006252-cbelsymu 302 9 1968 1968 CD cord-006252-cbelsymu 302 10 and and CC cord-006252-cbelsymu 302 11 1988 1988 CD cord-006252-cbelsymu 302 12 . . . cord-006252-cbelsymu 303 1 A a DT cord-006252-cbelsymu 303 2 total total JJ cord-006252-cbelsymu 303 3 Drugs drug NNS cord-006252-cbelsymu 303 4 & & CC cord-006252-cbelsymu 303 5 Aging Aging NNP cord-006252-cbelsymu 303 6 1 1 CD cord-006252-cbelsymu 303 7 ( ( -LRB- cord-006252-cbelsymu 303 8 6 6 CD cord-006252-cbelsymu 303 9 ) ) -RRB- cord-006252-cbelsymu 303 10 1991 1991 CD cord-006252-cbelsymu 303 11 of of IN cord-006252-cbelsymu 303 12 30 30 CD cord-006252-cbelsymu 303 13 comparisons comparison NNS cord-006252-cbelsymu 303 14 were be VBD cord-006252-cbelsymu 303 15 available available JJ cord-006252-cbelsymu 303 16 in in IN cord-006252-cbelsymu 303 17 the the DT cord-006252-cbelsymu 303 18 17 17 CD cord-006252-cbelsymu 303 19 papers paper NNS cord-006252-cbelsymu 303 20 . . . cord-006252-cbelsymu 304 1 In in IN cord-006252-cbelsymu 304 2 10 10 CD cord-006252-cbelsymu 304 3 , , , cord-006252-cbelsymu 304 4 the the DT cord-006252-cbelsymu 304 5 immune immune JJ cord-006252-cbelsymu 304 6 response response NN cord-006252-cbelsymu 304 7 was be VBD cord-006252-cbelsymu 304 8 superior superior JJ cord-006252-cbelsymu 304 9 in in IN cord-006252-cbelsymu 304 10 young young JJ cord-006252-cbelsymu 304 11 subjects subject NNS cord-006252-cbelsymu 304 12 ; ; : cord-006252-cbelsymu 304 13 in in IN cord-006252-cbelsymu 304 14 4 4 CD cord-006252-cbelsymu 304 15 , , , cord-006252-cbelsymu 304 16 the the DT cord-006252-cbelsymu 304 17 elderly elderly JJ cord-006252-cbelsymu 304 18 responded respond VBD cord-006252-cbelsymu 304 19 better well RBR cord-006252-cbelsymu 304 20 , , , cord-006252-cbelsymu 304 21 and and CC cord-006252-cbelsymu 304 22 in in IN cord-006252-cbelsymu 304 23 16 16 CD cord-006252-cbelsymu 304 24 , , , cord-006252-cbelsymu 304 25 no no DT cord-006252-cbelsymu 304 26 significant significant JJ cord-006252-cbelsymu 304 27 difference difference NN cord-006252-cbelsymu 304 28 was be VBD cord-006252-cbelsymu 304 29 noted note VBN cord-006252-cbelsymu 304 30 between between IN cord-006252-cbelsymu 304 31 the the DT cord-006252-cbelsymu 304 32 young young JJ cord-006252-cbelsymu 304 33 and and CC cord-006252-cbelsymu 304 34 old old JJ cord-006252-cbelsymu 304 35 subjects subject NNS cord-006252-cbelsymu 304 36 ; ; : cord-006252-cbelsymu 304 37 in in IN cord-006252-cbelsymu 304 38 this this DT cord-006252-cbelsymu 304 39 instance instance NN cord-006252-cbelsymu 304 40 , , , cord-006252-cbelsymu 304 41 the the DT cord-006252-cbelsymu 304 42 lack lack NN cord-006252-cbelsymu 304 43 of of IN cord-006252-cbelsymu 304 44 differences difference NNS cord-006252-cbelsymu 304 45 may may MD cord-006252-cbelsymu 304 46 have have VB cord-006252-cbelsymu 304 47 been be VBN cord-006252-cbelsymu 304 48 due due JJ cord-006252-cbelsymu 304 49 to to IN cord-006252-cbelsymu 304 50 a a DT cord-006252-cbelsymu 304 51 type type NN cord-006252-cbelsymu 304 52 2 2 CD cord-006252-cbelsymu 304 53 error error NN cord-006252-cbelsymu 304 54 because because IN cord-006252-cbelsymu 304 55 the the DT cord-006252-cbelsymu 304 56 numbers number NNS cord-006252-cbelsymu 304 57 studied study VBN cord-006252-cbelsymu 304 58 were be VBD cord-006252-cbelsymu 304 59 low low JJ cord-006252-cbelsymu 304 60 . . . cord-006252-cbelsymu 305 1 pointed point VBD cord-006252-cbelsymu 305 2 out out RP cord-006252-cbelsymu 305 3 3 3 CD cord-006252-cbelsymu 305 4 methodological methodological JJ cord-006252-cbelsymu 305 5 limitations limitation NNS cord-006252-cbelsymu 305 6 . . . cord-006252-cbelsymu 306 1 The the DT cord-006252-cbelsymu 306 2 studies study NNS cord-006252-cbelsymu 306 3 included include VBD cord-006252-cbelsymu 306 4 , , , cord-006252-cbelsymu 306 5 firstly firstly RB cord-006252-cbelsymu 306 6 , , , cord-006252-cbelsymu 306 7 subjects subject NNS cord-006252-cbelsymu 306 8 with with IN cord-006252-cbelsymu 306 9 illnesses illness NNS cord-006252-cbelsymu 306 10 or or CC cord-006252-cbelsymu 306 11 taking take VBG cord-006252-cbelsymu 306 12 drugs drug NNS cord-006252-cbelsymu 306 13 , , , cord-006252-cbelsymu 306 14 which which WDT cord-006252-cbelsymu 306 15 affect affect VBP cord-006252-cbelsymu 306 16 the the DT cord-006252-cbelsymu 306 17 immune immune JJ cord-006252-cbelsymu 306 18 system system NN cord-006252-cbelsymu 306 19 ; ; : cord-006252-cbelsymu 306 20 secondly secondly RB cord-006252-cbelsymu 306 21 , , , cord-006252-cbelsymu 306 22 patients patient NNS cord-006252-cbelsymu 306 23 immunised immunise VBD cord-006252-cbelsymu 306 24 previously previously RB cord-006252-cbelsymu 306 25 with with IN cord-006252-cbelsymu 306 26 influenza influenza NN cord-006252-cbelsymu 306 27 vaccine vaccine NN cord-006252-cbelsymu 306 28 ; ; : cord-006252-cbelsymu 306 29 and and CC cord-006252-cbelsymu 306 30 finally finally RB cord-006252-cbelsymu 306 31 , , , cord-006252-cbelsymu 306 32 those those DT cord-006252-cbelsymu 306 33 with with IN cord-006252-cbelsymu 306 34 protective protective JJ cord-006252-cbelsymu 306 35 antibody antibody NN cord-006252-cbelsymu 306 36 levels level NNS cord-006252-cbelsymu 306 37 before before IN cord-006252-cbelsymu 306 38 immunisation immunisation NN cord-006252-cbelsymu 306 39 . . . cord-006252-cbelsymu 307 1 Inclusion inclusion NN cord-006252-cbelsymu 307 2 of of IN cord-006252-cbelsymu 307 3 patients patient NNS cord-006252-cbelsymu 307 4 with with IN cord-006252-cbelsymu 307 5 any any DT cord-006252-cbelsymu 307 6 of of IN cord-006252-cbelsymu 307 7 these these DT cord-006252-cbelsymu 307 8 3 3 CD cord-006252-cbelsymu 307 9 factors factor NNS cord-006252-cbelsymu 307 10 would would MD cord-006252-cbelsymu 307 11 tend tend VB cord-006252-cbelsymu 307 12 to to TO cord-006252-cbelsymu 307 13 underestimate underestimate VB cord-006252-cbelsymu 307 14 the the DT cord-006252-cbelsymu 307 15 ability ability NN cord-006252-cbelsymu 307 16 of of IN cord-006252-cbelsymu 307 17 elderly elderly JJ cord-006252-cbelsymu 307 18 subjects subject NNS cord-006252-cbelsymu 307 19 to to TO cord-006252-cbelsymu 307 20 respond respond VB cord-006252-cbelsymu 307 21 to to IN cord-006252-cbelsymu 307 22 immunisation immunisation NN cord-006252-cbelsymu 307 23 . . . cord-006252-cbelsymu 308 1 The the DT cord-006252-cbelsymu 308 2 association association NN cord-006252-cbelsymu 308 3 between between IN cord-006252-cbelsymu 308 4 increasing increase VBG cord-006252-cbelsymu 308 5 age age NN cord-006252-cbelsymu 308 6 and and CC cord-006252-cbelsymu 308 7 a a DT cord-006252-cbelsymu 308 8 poor poor JJ cord-006252-cbelsymu 308 9 immune immune JJ cord-006252-cbelsymu 308 10 response response NN cord-006252-cbelsymu 308 11 to to IN cord-006252-cbelsymu 308 12 influenza influenza NN cord-006252-cbelsymu 308 13 vaccine vaccine NN cord-006252-cbelsymu 308 14 has have VBZ cord-006252-cbelsymu 308 15 thus thus RB cord-006252-cbelsymu 308 16 not not RB cord-006252-cbelsymu 308 17 yet yet RB cord-006252-cbelsymu 308 18 been be VBN cord-006252-cbelsymu 308 19 convincingly convincingly RB cord-006252-cbelsymu 308 20 made make VBN cord-006252-cbelsymu 308 21 . . . cord-006252-cbelsymu 309 1 Perhaps perhaps RB cord-006252-cbelsymu 309 2 a a DT cord-006252-cbelsymu 309 3 small small JJ cord-006252-cbelsymu 309 4 subgroup subgroup NN cord-006252-cbelsymu 309 5 of of IN cord-006252-cbelsymu 309 6 the the DT cord-006252-cbelsymu 309 7 elderly elderly JJ cord-006252-cbelsymu 309 8 population population NN cord-006252-cbelsymu 309 9 respond respond VBP cord-006252-cbelsymu 309 10 poorly poorly RB cord-006252-cbelsymu 309 11 while while IN cord-006252-cbelsymu 309 12 most most JJS cord-006252-cbelsymu 309 13 respond respond VBP cord-006252-cbelsymu 309 14 normally normally RB cord-006252-cbelsymu 309 15 . . . cord-006252-cbelsymu 310 1 This this DT cord-006252-cbelsymu 310 2 was be VBD cord-006252-cbelsymu 310 3 originally originally RB cord-006252-cbelsymu 310 4 suggested suggest VBN cord-006252-cbelsymu 310 5 in in IN cord-006252-cbelsymu 310 6 a a DT cord-006252-cbelsymu 310 7 study study NN cord-006252-cbelsymu 310 8 by by IN cord-006252-cbelsymu 310 9 Phair Phair NNP cord-006252-cbelsymu 310 10 et et NNP cord-006252-cbelsymu 310 11 al al NNP cord-006252-cbelsymu 310 12 . . . cord-006252-cbelsymu 311 1 ( ( -LRB- cord-006252-cbelsymu 311 2 1978 1978 CD cord-006252-cbelsymu 311 3 ) ) -RRB- cord-006252-cbelsymu 311 4 examining examine VBG cord-006252-cbelsymu 311 5 the the DT cord-006252-cbelsymu 311 6 T T NNP cord-006252-cbelsymu 311 7 cell cell NN cord-006252-cbelsymu 311 8 response response NN cord-006252-cbelsymu 311 9 of of IN cord-006252-cbelsymu 311 10 infirm infirm JJ cord-006252-cbelsymu 311 11 elderly elderly JJ cord-006252-cbelsymu 311 12 to to TO cord-006252-cbelsymu 311 13 influenza influenza NN cord-006252-cbelsymu 311 14 antigens antigen NNS cord-006252-cbelsymu 311 15 . . . cord-006252-cbelsymu 312 1 More more RBR cord-006252-cbelsymu 312 2 recently recently RB cord-006252-cbelsymu 312 3 , , , cord-006252-cbelsymu 312 4 in in IN cord-006252-cbelsymu 312 5 a a DT cord-006252-cbelsymu 312 6 study study NN cord-006252-cbelsymu 312 7 by by IN cord-006252-cbelsymu 312 8 , , , cord-006252-cbelsymu 312 9 bedridden bedridden JJ cord-006252-cbelsymu 312 10 , , , cord-006252-cbelsymu 312 11 infirm infirm JJ cord-006252-cbelsymu 312 12 elderly elderly JJ cord-006252-cbelsymu 312 13 patients patient NNS cord-006252-cbelsymu 312 14 appeared appear VBD cord-006252-cbelsymu 312 15 to to TO cord-006252-cbelsymu 312 16 respond respond VB cord-006252-cbelsymu 312 17 less less RBR cord-006252-cbelsymu 312 18 well well RB cord-006252-cbelsymu 312 19 to to IN cord-006252-cbelsymu 312 20 influenza influenza NN cord-006252-cbelsymu 312 21 vaccine vaccine NN cord-006252-cbelsymu 312 22 than than IN cord-006252-cbelsymu 312 23 did do VBD cord-006252-cbelsymu 312 24 healthy healthy JJ cord-006252-cbelsymu 312 25 , , , cord-006252-cbelsymu 312 26 ambulatory ambulatory JJ cord-006252-cbelsymu 312 27 elderly elderly JJ cord-006252-cbelsymu 312 28 patients patient NNS cord-006252-cbelsymu 312 29 . . . cord-006252-cbelsymu 313 1 Alternative alternative JJ cord-006252-cbelsymu 313 2 approaches approach NNS cord-006252-cbelsymu 313 3 to to IN cord-006252-cbelsymu 313 4 the the DT cord-006252-cbelsymu 313 5 standard standard JJ cord-006252-cbelsymu 313 6 immunisation immunisation NN cord-006252-cbelsymu 313 7 have have VBP cord-006252-cbelsymu 313 8 been be VBN cord-006252-cbelsymu 313 9 tried try VBN cord-006252-cbelsymu 313 10 . . . cord-006252-cbelsymu 314 1 Two two CD cord-006252-cbelsymu 314 2 doses dose NNS cord-006252-cbelsymu 314 3 1 1 CD cord-006252-cbelsymu 314 4 month month NN cord-006252-cbelsymu 314 5 apart apart RB cord-006252-cbelsymu 314 6 did do VBD cord-006252-cbelsymu 314 7 not not RB cord-006252-cbelsymu 314 8 improve improve VB cord-006252-cbelsymu 314 9 the the DT cord-006252-cbelsymu 314 10 immune immune JJ cord-006252-cbelsymu 314 11 response response NN cord-006252-cbelsymu 314 12 , , , cord-006252-cbelsymu 314 13 neither neither CC cord-006252-cbelsymu 314 14 did do VBD cord-006252-cbelsymu 314 15 2 2 CD cord-006252-cbelsymu 314 16 and and CC cord-006252-cbelsymu 314 17 3 3 CD cord-006252-cbelsymu 314 18 times time NNS cord-006252-cbelsymu 314 19 the the DT cord-006252-cbelsymu 314 20 standard standard JJ cord-006252-cbelsymu 314 21 dose dose NN cord-006252-cbelsymu 314 22 . . . cord-006252-cbelsymu 315 1 From from IN cord-006252-cbelsymu 315 2 currently currently RB cord-006252-cbelsymu 315 3 available available JJ cord-006252-cbelsymu 315 4 information information NN cord-006252-cbelsymu 315 5 we -PRON- PRP cord-006252-cbelsymu 315 6 can can MD cord-006252-cbelsymu 315 7 conclude conclude VB cord-006252-cbelsymu 315 8 that that IN cord-006252-cbelsymu 315 9 the the DT cord-006252-cbelsymu 315 10 recommended recommend VBN cord-006252-cbelsymu 315 11 single single JJ cord-006252-cbelsymu 315 12 standard standard JJ cord-006252-cbelsymu 315 13 dose dose NN cord-006252-cbelsymu 315 14 of of IN cord-006252-cbelsymu 315 15 killed kill VBN cord-006252-cbelsymu 315 16 influenza influenza NN cord-006252-cbelsymu 315 17 vaccine vaccine NN cord-006252-cbelsymu 315 18 will will MD cord-006252-cbelsymu 315 19 stimulate stimulate VB cord-006252-cbelsymu 315 20 an an DT cord-006252-cbelsymu 315 21 adequate adequate JJ cord-006252-cbelsymu 315 22 immune immune JJ cord-006252-cbelsymu 315 23 response response NN cord-006252-cbelsymu 315 24 in in IN cord-006252-cbelsymu 315 25 most most JJS cord-006252-cbelsymu 315 26 elderly elderly JJ cord-006252-cbelsymu 315 27 persons person NNS cord-006252-cbelsymu 315 28 . . . cord-006252-cbelsymu 316 1 Finally finally RB cord-006252-cbelsymu 316 2 , , , cord-006252-cbelsymu 316 3 and and CC cord-006252-cbelsymu 316 4 most most RBS cord-006252-cbelsymu 316 5 importantly importantly RB cord-006252-cbelsymu 316 6 , , , cord-006252-cbelsymu 316 7 in in IN cord-006252-cbelsymu 316 8 a a DT cord-006252-cbelsymu 316 9 number number NN cord-006252-cbelsymu 316 10 of of IN cord-006252-cbelsymu 316 11 recent recent JJ cord-006252-cbelsymu 316 12 studies study NNS cord-006252-cbelsymu 316 13 influenza influenza NN cord-006252-cbelsymu 316 14 vaccine vaccine NN cord-006252-cbelsymu 316 15 has have VBZ cord-006252-cbelsymu 316 16 been be VBN cord-006252-cbelsymu 316 17 shown show VBN cord-006252-cbelsymu 316 18 to to TO cord-006252-cbelsymu 316 19 reduce reduce VB cord-006252-cbelsymu 316 20 mortality mortality NN cord-006252-cbelsymu 316 21 from from IN cord-006252-cbelsymu 316 22 influenza influenza NN cord-006252-cbelsymu 316 23 virus virus NN cord-006252-cbelsymu 316 24 infection infection NN cord-006252-cbelsymu 316 25 Gross Gross NNP cord-006252-cbelsymu 316 26 et et FW cord-006252-cbelsymu 316 27 al al NNP cord-006252-cbelsymu 316 28 . . NNP cord-006252-cbelsymu 316 29 1988a 1988a CD cord-006252-cbelsymu 316 30 ) ) -RRB- cord-006252-cbelsymu 316 31 . . . cord-006252-cbelsymu 317 1 Recent recent JJ cord-006252-cbelsymu 317 2 studies study NNS cord-006252-cbelsymu 317 3 on on IN cord-006252-cbelsymu 317 4 the the DT cord-006252-cbelsymu 317 5 adverse adverse JJ cord-006252-cbelsymu 317 6 effects effect NNS cord-006252-cbelsymu 317 7 of of IN cord-006252-cbelsymu 317 8 influenza influenza NN cord-006252-cbelsymu 317 9 vaccine vaccine NN cord-006252-cbelsymu 317 10 show show VBP cord-006252-cbelsymu 317 11 that that IN cord-006252-cbelsymu 317 12 the the DT cord-006252-cbelsymu 317 13 vaccine vaccine NN cord-006252-cbelsymu 317 14 is be VBZ cord-006252-cbelsymu 317 15 typically typically RB cord-006252-cbelsymu 317 16 well well RB cord-006252-cbelsymu 317 17 tolerated tolerate VBN cord-006252-cbelsymu 317 18 . . . cord-006252-cbelsymu 318 1 For for IN cord-006252-cbelsymu 318 2 example example NN cord-006252-cbelsymu 318 3 , , , cord-006252-cbelsymu 318 4 Margolis Margolis NNP cord-006252-cbelsymu 318 5 et et NNP cord-006252-cbelsymu 318 6 a1 a1 NNP cord-006252-cbelsymu 318 7 . . . cord-006252-cbelsymu 319 1 ( ( -LRB- cord-006252-cbelsymu 319 2 1990a 1990a CD cord-006252-cbelsymu 319 3 , , , cord-006252-cbelsymu 319 4 b b LS cord-006252-cbelsymu 319 5 ) ) -RRB- cord-006252-cbelsymu 319 6 reported report VBD cord-006252-cbelsymu 319 7 that that IN cord-006252-cbelsymu 319 8 in in IN cord-006252-cbelsymu 319 9 elderly elderly JJ cord-006252-cbelsymu 319 10 chronically chronically RB cord-006252-cbelsymu 319 11 ill ill JJ cord-006252-cbelsymu 319 12 patients patient NNS cord-006252-cbelsymu 319 13 fever fever NN cord-006252-cbelsymu 319 14 and and CC cord-006252-cbelsymu 319 15 significant significant JJ cord-006252-cbelsymu 319 16 disability disability NN cord-006252-cbelsymu 319 17 could could MD cord-006252-cbelsymu 319 18 not not RB cord-006252-cbelsymu 319 19 be be VB cord-006252-cbelsymu 319 20 attributed attribute VBN cord-006252-cbelsymu 319 21 to to IN cord-006252-cbelsymu 319 22 the the DT cord-006252-cbelsymu 319 23 vaccine vaccine NN cord-006252-cbelsymu 319 24 compared compare VBN cord-006252-cbelsymu 319 25 to to IN cord-006252-cbelsymu 319 26 a a DT cord-006252-cbelsymu 319 27 control control NN cord-006252-cbelsymu 319 28 group group NN cord-006252-cbelsymu 319 29 . . . cord-006252-cbelsymu 320 1 A a DT cord-006252-cbelsymu 320 2 flu flu NN cord-006252-cbelsymu 320 3 - - HYPH cord-006252-cbelsymu 320 4 like like JJ cord-006252-cbelsymu 320 5 illness illness NN cord-006252-cbelsymu 320 6 , , , cord-006252-cbelsymu 320 7 however however RB cord-006252-cbelsymu 320 8 , , , cord-006252-cbelsymu 320 9 was be VBD cord-006252-cbelsymu 320 10 attributable attributable JJ cord-006252-cbelsymu 320 11 to to IN cord-006252-cbelsymu 320 12 vaccine vaccine NN cord-006252-cbelsymu 320 13 in in IN cord-006252-cbelsymu 320 14 5.5 5.5 CD cord-006252-cbelsymu 320 15 % % NN cord-006252-cbelsymu 320 16 . . . cord-006252-cbelsymu 321 1 They -PRON- PRP cord-006252-cbelsymu 321 2 concluded conclude VBD cord-006252-cbelsymu 321 3 that that IN cord-006252-cbelsymu 321 4 the the DT cord-006252-cbelsymu 321 5 overall overall JJ cord-006252-cbelsymu 321 6 frequency frequency NN cord-006252-cbelsymu 321 7 of of IN cord-006252-cbelsymu 321 8 adverse adverse JJ cord-006252-cbelsymu 321 9 effects effect NNS cord-006252-cbelsymu 321 10 was be VBD cord-006252-cbelsymu 321 11 low low JJ cord-006252-cbelsymu 321 12 . . . cord-006252-cbelsymu 322 1 Another another DT cord-006252-cbelsymu 322 2 area area NN cord-006252-cbelsymu 322 3 of of IN cord-006252-cbelsymu 322 4 concern concern NN cord-006252-cbelsymu 322 5 is be VBZ cord-006252-cbelsymu 322 6 the the DT cord-006252-cbelsymu 322 7 effect effect NN cord-006252-cbelsymu 322 8 of of IN cord-006252-cbelsymu 322 9 vaccine vaccine NN cord-006252-cbelsymu 322 10 on on IN cord-006252-cbelsymu 322 11 drug drug NN cord-006252-cbelsymu 322 12 metabolism metabolism NN cord-006252-cbelsymu 322 13 . . . cord-006252-cbelsymu 323 1 The the DT cord-006252-cbelsymu 323 2 mechanism mechanism NN cord-006252-cbelsymu 323 3 postulated postulate VBN cord-006252-cbelsymu 323 4 is be VBZ cord-006252-cbelsymu 323 5 vaccine vaccine NN cord-006252-cbelsymu 323 6 suppression suppression NN cord-006252-cbelsymu 323 7 of of IN cord-006252-cbelsymu 323 8 oxidative oxidative JJ cord-006252-cbelsymu 323 9 hepatic hepatic JJ cord-006252-cbelsymu 323 10 metabolism metabolism NN cord-006252-cbelsymu 323 11 . . . cord-006252-cbelsymu 324 1 Interferon interferon NN cord-006252-cbelsymu 324 2 production production NN cord-006252-cbelsymu 324 3 induced induce VBN cord-006252-cbelsymu 324 4 by by IN cord-006252-cbelsymu 324 5 vaccination vaccination NN cord-006252-cbelsymu 324 6 is be VBZ cord-006252-cbelsymu 324 7 supposed suppose VBN cord-006252-cbelsymu 324 8 to to TO cord-006252-cbelsymu 324 9 block block VB cord-006252-cbelsymu 324 10 the the DT cord-006252-cbelsymu 324 11 oxidative oxidative JJ cord-006252-cbelsymu 324 12 cytochrome cytochrome NN cord-006252-cbelsymu 324 13 P450 p450 NN cord-006252-cbelsymu 324 14 system system NN cord-006252-cbelsymu 324 15 , , , cord-006252-cbelsymu 324 16 resulting result VBG cord-006252-cbelsymu 324 17 in in IN cord-006252-cbelsymu 324 18 accumulation accumulation NN cord-006252-cbelsymu 324 19 of of IN cord-006252-cbelsymu 324 20 certain certain JJ cord-006252-cbelsymu 324 21 drugs drug NNS cord-006252-cbelsymu 324 22 . . . cord-006252-cbelsymu 325 1 Metabolism metabolism NN cord-006252-cbelsymu 325 2 of of IN cord-006252-cbelsymu 325 3 theophylline theophylline NN cord-006252-cbelsymu 325 4 , , , cord-006252-cbelsymu 325 5 chlordiazepoxide chlordiazepoxide NN cord-006252-cbelsymu 325 6 , , , cord-006252-cbelsymu 325 7 lorazepam lorazepam NN cord-006252-cbelsymu 325 8 , , , cord-006252-cbelsymu 325 9 warfarin warfarin NN cord-006252-cbelsymu 325 10 , , , cord-006252-cbelsymu 325 11 phenytoin phenytoin NN cord-006252-cbelsymu 325 12 and and CC cord-006252-cbelsymu 325 13 phenobarbital phenobarbital NN cord-006252-cbelsymu 325 14 ( ( -LRB- cord-006252-cbelsymu 325 15 phenobarbitone phenobarbitone NNP cord-006252-cbelsymu 325 16 ) ) -RRB- cord-006252-cbelsymu 325 17 has have VBZ cord-006252-cbelsymu 325 18 been be VBN cord-006252-cbelsymu 325 19 studied study VBN cord-006252-cbelsymu 325 20 , , , cord-006252-cbelsymu 325 21 with with IN cord-006252-cbelsymu 325 22 variable variable JJ cord-006252-cbelsymu 325 23 results result NNS cord-006252-cbelsymu 325 24 . . . cord-006252-cbelsymu 326 1 For for IN cord-006252-cbelsymu 326 2 theophylline theophylline NN cord-006252-cbelsymu 326 3 , , , cord-006252-cbelsymu 326 4 in in IN cord-006252-cbelsymu 326 5 particular particular JJ cord-006252-cbelsymu 326 6 , , , cord-006252-cbelsymu 326 7 most most JJS cord-006252-cbelsymu 326 8 studies study NNS cord-006252-cbelsymu 326 9 seem seem VBP cord-006252-cbelsymu 326 10 to to TO cord-006252-cbelsymu 326 11 indicate indicate VB cord-006252-cbelsymu 326 12 that that IN cord-006252-cbelsymu 326 13 the the DT cord-006252-cbelsymu 326 14 effect effect NN cord-006252-cbelsymu 326 15 of of IN cord-006252-cbelsymu 326 16 vaccine vaccine NN cord-006252-cbelsymu 326 17 is be VBZ cord-006252-cbelsymu 326 18 minor minor JJ cord-006252-cbelsymu 327 1 ( ( -LRB- cord-006252-cbelsymu 327 2 Gomolin Gomolin NNP cord-006252-cbelsymu 327 3 et et NNP cord-006252-cbelsymu 327 4 a1 a1 NN cord-006252-cbelsymu 327 5 . . . cord-006252-cbelsymu 328 1 1985 1985 CD cord-006252-cbelsymu 328 2 ; ; : cord-006252-cbelsymu 328 3 Grabowski Grabowski NNP cord-006252-cbelsymu 328 4 et et NNP cord-006252-cbelsymu 328 5 a1 a1 NNP cord-006252-cbelsymu 328 6 . . . cord-006252-cbelsymu 328 7 1985 1985 CD cord-006252-cbelsymu 328 8 ; ; : cord-006252-cbelsymu 328 9 Meredith Meredith NNP cord-006252-cbelsymu 328 10 et et NNP cord-006252-cbelsymu 328 11 a1 a1 NNP cord-006252-cbelsymu 328 12 . . . cord-006252-cbelsymu 328 13 1985 1985 CD cord-006252-cbelsymu 328 14 ) ) -RRB- cord-006252-cbelsymu 328 15 . . . cord-006252-cbelsymu 329 1 Less Less JJR cord-006252-cbelsymu 329 2 than than IN cord-006252-cbelsymu 329 3 30 30 CD cord-006252-cbelsymu 329 4 % % NN cord-006252-cbelsymu 329 5 of of IN cord-006252-cbelsymu 329 6 high high JJ cord-006252-cbelsymu 329 7 risk risk NN cord-006252-cbelsymu 329 8 persons person NNS cord-006252-cbelsymu 329 9 are be VBP cord-006252-cbelsymu 329 10 vaccinated vaccinate VBN cord-006252-cbelsymu 329 11 annually annually RB cord-006252-cbelsymu 329 12 . . . cord-006252-cbelsymu 330 1 Consequently consequently RB cord-006252-cbelsymu 330 2 many many JJ cord-006252-cbelsymu 330 3 studies study NNS cord-006252-cbelsymu 330 4 have have VBP cord-006252-cbelsymu 330 5 been be VBN cord-006252-cbelsymu 330 6 undertaken undertake VBN cord-006252-cbelsymu 330 7 to to TO cord-006252-cbelsymu 330 8 determine determine VB cord-006252-cbelsymu 330 9 the the DT cord-006252-cbelsymu 330 10 best good JJS cord-006252-cbelsymu 330 11 strategies strategy NNS cord-006252-cbelsymu 330 12 for for IN cord-006252-cbelsymu 330 13 immunising immunise VBG cord-006252-cbelsymu 330 14 appropriate appropriate JJ cord-006252-cbelsymu 330 15 groups group NNS cord-006252-cbelsymu 330 16 . . . cord-006252-cbelsymu 331 1 The the DT cord-006252-cbelsymu 331 2 current current JJ cord-006252-cbelsymu 331 3 strategies strategy NNS cord-006252-cbelsymu 331 4 for for IN cord-006252-cbelsymu 331 5 implementing implement VBG cord-006252-cbelsymu 331 6 the the DT cord-006252-cbelsymu 331 7 influenza influenza NN cord-006252-cbelsymu 331 8 vaccine vaccine NN cord-006252-cbelsymu 331 9 recommendations recommendation NNS cord-006252-cbelsymu 331 10 include include VBP cord-006252-cbelsymu 331 11 immunising immunise VBG cord-006252-cbelsymu 331 12 persons person NNS cord-006252-cbelsymu 331 13 in in IN cord-006252-cbelsymu 331 14 the the DT cord-006252-cbelsymu 331 15 following follow VBG cord-006252-cbelsymu 331 16 settings setting NNS cord-006252-cbelsymu 331 17 ( ( -LRB- cord-006252-cbelsymu 331 18 Recommendations Recommendations NNPS cord-006252-cbelsymu 331 19 of of IN cord-006252-cbelsymu 331 20 the the DT cord-006252-cbelsymu 331 21 Immunization Immunization NNP cord-006252-cbelsymu 331 22 Practices Practices NNPS cord-006252-cbelsymu 331 23 Advisory Advisory NNP cord-006252-cbelsymu 331 24 Committee Committee NNP cord-006252-cbelsymu 331 25 1990 1990 CD cord-006252-cbelsymu 331 26 ) ) -RRB- cord-006252-cbelsymu 331 27 . . . cord-006252-cbelsymu 332 1 1 1 LS cord-006252-cbelsymu 332 2 . . . cord-006252-cbelsymu 333 1 In in IN cord-006252-cbelsymu 333 2 outpatient outpatient NN cord-006252-cbelsymu 333 3 clinics clinic NNS cord-006252-cbelsymu 333 4 and and CC cord-006252-cbelsymu 333 5 physicians physician NNS cord-006252-cbelsymu 333 6 ' ' POS cord-006252-cbelsymu 333 7 offices office NNS cord-006252-cbelsymu 333 8 label label VBP cord-006252-cbelsymu 333 9 medical medical JJ cord-006252-cbelsymu 333 10 records record NNS cord-006252-cbelsymu 333 11 of of IN cord-006252-cbelsymu 333 12 high high JJ cord-006252-cbelsymu 333 13 risk risk NN cord-006252-cbelsymu 333 14 persons person NNS cord-006252-cbelsymu 333 15 ; ; : cord-006252-cbelsymu 333 16 use use VB cord-006252-cbelsymu 333 17 mail mail NN cord-006252-cbelsymu 333 18 or or CC cord-006252-cbelsymu 333 19 telephone telephone NN cord-006252-cbelsymu 333 20 reminders reminder NNS cord-006252-cbelsymu 333 21 ; ; : cord-006252-cbelsymu 333 22 begin begin VB cord-006252-cbelsymu 333 23 vaccinating vaccinate VBG cord-006252-cbelsymu 333 24 in in IN cord-006252-cbelsymu 333 25 September September NNP cord-006252-cbelsymu 333 26 ( ( -LRB- cord-006252-cbelsymu 333 27 Northern Northern NNP cord-006252-cbelsymu 333 28 Hemisphere Hemisphere NNP cord-006252-cbelsymu 333 29 ) ) -RRB- cord-006252-cbelsymu 334 1 [ [ -LRB- cord-006252-cbelsymu 334 2 Buchner Buchner NNP cord-006252-cbelsymu 334 3 et et NNP cord-006252-cbelsymu 334 4 a1 a1 NNP cord-006252-cbelsymu 334 5 . . . cord-006252-cbelsymu 334 6 1987 1987 CD cord-006252-cbelsymu 334 7 ] ] -RRB- cord-006252-cbelsymu 335 1 and and CC cord-006252-cbelsymu 335 2 March March NNP cord-006252-cbelsymu 335 3 ( ( -LRB- cord-006252-cbelsymu 335 4 Southern Southern NNP cord-006252-cbelsymu 335 5 Hemisphere Hemisphere NNP cord-006252-cbelsymu 335 6 ) ) -RRB- cord-006252-cbelsymu 335 7 . . . cord-006252-cbelsymu 336 1 2 2 LS cord-006252-cbelsymu 336 2 . . . cord-006252-cbelsymu 337 1 In in IN cord-006252-cbelsymu 337 2 facilities facility NNS cord-006252-cbelsymu 337 3 providing provide VBG cord-006252-cbelsymu 337 4 episodic episodic JJ cord-006252-cbelsymu 337 5 or or CC cord-006252-cbelsymu 337 6 acute acute JJ cord-006252-cbelsymu 337 7 care care NN cord-006252-cbelsymu 337 8 ( ( -LRB- cord-006252-cbelsymu 337 9 e.g. e.g. RB cord-006252-cbelsymu 337 10 emergency emergency NN cord-006252-cbelsymu 337 11 rooms room NNS cord-006252-cbelsymu 337 12 , , , cord-006252-cbelsymu 337 13 walk walk NN cord-006252-cbelsymu 337 14 - - HYPH cord-006252-cbelsymu 337 15 in in RP cord-006252-cbelsymu 337 16 clinics clinic NNS cord-006252-cbelsymu 337 17 ) ) -RRB- cord-006252-cbelsymu 338 1 healthcare healthcare NN cord-006252-cbelsymu 338 2 providers provider NNS cord-006252-cbelsymu 338 3 be be VB cord-006252-cbelsymu 338 4 aware aware JJ cord-006252-cbelsymu 338 5 of of IN cord-006252-cbelsymu 338 6 high high JJ cord-006252-cbelsymu 338 7 risk risk NN cord-006252-cbelsymu 338 8 groups group NNS cord-006252-cbelsymu 338 9 ; ; : cord-006252-cbelsymu 338 10 provide provide VB cord-006252-cbelsymu 338 11 written write VBN cord-006252-cbelsymu 338 12 information information NN cord-006252-cbelsymu 338 13 in in IN cord-006252-cbelsymu 338 14 appropriate appropriate JJ cord-006252-cbelsymu 338 15 languages language NNS cord-006252-cbelsymu 338 16 . . . cord-006252-cbelsymu 339 1 3 3 LS cord-006252-cbelsymu 339 2 . . . cord-006252-cbelsymu 340 1 In in IN cord-006252-cbelsymu 340 2 nursing nursing NN cord-006252-cbelsymu 340 3 homes home NNS cord-006252-cbelsymu 340 4 and and CC cord-006252-cbelsymu 340 5 other other JJ cord-006252-cbelsymu 340 6 residential residential JJ cord-006252-cbelsymu 340 7 long long JJ cord-006252-cbelsymu 340 8 term term NN cord-006252-cbelsymu 340 9 care care NN cord-006252-cbelsymu 340 10 facilities facility NNS cord-006252-cbelsymu 340 11 vaccinate vaccinate VBP cord-006252-cbelsymu 340 12 all all DT cord-006252-cbelsymu 340 13 residents resident NNS cord-006252-cbelsymu 340 14 with with IN cord-006252-cbelsymu 340 15 the the DT cord-006252-cbelsymu 340 16 prior prior JJ cord-006252-cbelsymu 340 17 aggreement aggreement NN cord-006252-cbelsymu 340 18 of of IN cord-006252-cbelsymu 340 19 attending attend VBG cord-006252-cbelsymu 340 20 physicians physician NNS cord-006252-cbelsymu 340 21 ; ; : cord-006252-cbelsymu 340 22 do do VBP cord-006252-cbelsymu 340 23 not not RB cord-006252-cbelsymu 340 24 require require VB cord-006252-cbelsymu 340 25 individual individual JJ cord-006252-cbelsymu 340 26 physician physician NN cord-006252-cbelsymu 340 27 orders order NNS cord-006252-cbelsymu 340 28 ; ; : cord-006252-cbelsymu 340 29 obtain obtain VB cord-006252-cbelsymu 340 30 permission permission NN cord-006252-cbelsymu 340 31 for for IN cord-006252-cbelsymu 340 32 vaccination vaccination NN cord-006252-cbelsymu 340 33 on on IN cord-006252-cbelsymu 340 34 admission admission NN cord-006252-cbelsymu 340 35 to to IN cord-006252-cbelsymu 340 36 facility facility NN cord-006252-cbelsymu 340 37 . . . cord-006252-cbelsymu 341 1 437 437 CD cord-006252-cbelsymu 341 2 4 4 CD cord-006252-cbelsymu 341 3 . . . cord-006252-cbelsymu 342 1 In in IN cord-006252-cbelsymu 342 2 acute acute JJ cord-006252-cbelsymu 342 3 - - HYPH cord-006252-cbelsymu 342 4 care care NN cord-006252-cbelsymu 342 5 hospitals hospital NNS cord-006252-cbelsymu 342 6 encourage encourage VBP cord-006252-cbelsymu 342 7 vaccination vaccination NN cord-006252-cbelsymu 342 8 before before IN cord-006252-cbelsymu 342 9 discharge discharge NN cord-006252-cbelsymu 342 10 between between IN cord-006252-cbelsymu 342 11 September September NNP cord-006252-cbelsymu 342 12 and and CC cord-006252-cbelsymu 342 13 April April NNP cord-006252-cbelsymu 342 14 ( ( -LRB- cord-006252-cbelsymu 342 15 Northern Northern NNP cord-006252-cbelsymu 342 16 Hemisphere Hemisphere NNP cord-006252-cbelsymu 342 17 ) ) -RRB- cord-006252-cbelsymu 342 18 , , , cord-006252-cbelsymu 342 19 and and CC cord-006252-cbelsymu 342 20 March March NNP cord-006252-cbelsymu 342 21 to to IN cord-006252-cbelsymu 342 22 August August NNP cord-006252-cbelsymu 342 23 ( ( -LRB- cord-006252-cbelsymu 342 24 Southern Southern NNP cord-006252-cbelsymu 342 25 Hemisphere Hemisphere NNP cord-006252-cbelsymu 342 26 ) ) -RRB- cord-006252-cbelsymu 342 27 of of IN cord-006252-cbelsymu 342 28 all all DT cord-006252-cbelsymu 342 29 persons person NNS cord-006252-cbelsymu 342 30 aged age VBN cord-006252-cbelsymu 342 31 65 65 CD cord-006252-cbelsymu 342 32 years year NNS cord-006252-cbelsymu 342 33 or or CC cord-006252-cbelsymu 342 34 over over RB cord-006252-cbelsymu 342 35 , , , cord-006252-cbelsymu 342 36 or or CC cord-006252-cbelsymu 342 37 with with IN cord-006252-cbelsymu 342 38 high high JJ cord-006252-cbelsymu 342 39 risk risk NN cord-006252-cbelsymu 342 40 conditions condition NNS cord-006252-cbelsymu 342 41 at at IN cord-006252-cbelsymu 342 42 any any DT cord-006252-cbelsymu 342 43 age age NN cord-006252-cbelsymu 342 44 . . . cord-006252-cbelsymu 343 1 5 5 LS cord-006252-cbelsymu 343 2 . . . cord-006252-cbelsymu 344 1 In in IN cord-006252-cbelsymu 344 2 outpatient outpatient NN cord-006252-cbelsymu 344 3 facilities facility NNS cord-006252-cbelsymu 344 4 providing provide VBG cord-006252-cbelsymu 344 5 continuing continue VBG cord-006252-cbelsymu 344 6 care care NN cord-006252-cbelsymu 344 7 to to IN cord-006252-cbelsymu 344 8 high high JJ cord-006252-cbelsymu 344 9 risk risk NN cord-006252-cbelsymu 344 10 patients patient NNS cord-006252-cbelsymu 344 11 ( ( -LRB- cord-006252-cbelsymu 344 12 e.g. e.g. IN cord-006252-cbelsymu 344 13 haemodialysis haemodialysis NNP cord-006252-cbelsymu 344 14 centres centre NNS cord-006252-cbelsymu 344 15 , , , cord-006252-cbelsymu 344 16 hospital hospital NN cord-006252-cbelsymu 344 17 speciality speciality NN cord-006252-cbelsymu 344 18 care care NN cord-006252-cbelsymu 344 19 clinics clinic NNS cord-006252-cbelsymu 344 20 , , , cord-006252-cbelsymu 344 21 outpatient outpatient NN cord-006252-cbelsymu 344 22 rehabilitation rehabilitation NN cord-006252-cbelsymu 344 23 programmes programme NNS cord-006252-cbelsymu 344 24 ) ) -RRB- cord-006252-cbelsymu 344 25 ; ; : cord-006252-cbelsymu 344 26 facilities facility NNS cord-006252-cbelsymu 344 27 providing provide VBG cord-006252-cbelsymu 344 28 services service NNS cord-006252-cbelsymu 344 29 to to IN cord-006252-cbelsymu 344 30 people people NNS cord-006252-cbelsymu 344 31 65 65 CD cord-006252-cbelsymu 344 32 years year NNS cord-006252-cbelsymu 344 33 and and CC cord-006252-cbelsymu 344 34 older old JJR cord-006252-cbelsymu 344 35 ( ( -LRB- cord-006252-cbelsymu 344 36 e.g. e.g. IN cord-006252-cbelsymu 344 37 retirement retirement NN cord-006252-cbelsymu 344 38 communities community NNS cord-006252-cbelsymu 344 39 , , , cord-006252-cbelsymu 344 40 recreation recreation NN cord-006252-cbelsymu 344 41 centres centre NNS cord-006252-cbelsymu 344 42 ) ) -RRB- cord-006252-cbelsymu 344 43 ; ; : cord-006252-cbelsymu 344 44 clinics clinic NNS cord-006252-cbelsymu 344 45 and and CC cord-006252-cbelsymu 344 46 other other JJ cord-006252-cbelsymu 344 47 centres centre NNS cord-006252-cbelsymu 344 48 providing provide VBG cord-006252-cbelsymu 344 49 healthcare healthcare NN cord-006252-cbelsymu 344 50 for for IN cord-006252-cbelsymu 344 51 travellers traveller NNS cord-006252-cbelsymu 344 52 ; ; : cord-006252-cbelsymu 344 53 healthcare healthcare NN cord-006252-cbelsymu 344 54 workers worker NNS cord-006252-cbelsymu 344 55 , , , cord-006252-cbelsymu 344 56 visiting visit VBG cord-006252-cbelsymu 344 57 nurses nurse NNS cord-006252-cbelsymu 344 58 and and CC cord-006252-cbelsymu 344 59 others other NNS cord-006252-cbelsymu 344 60 providing provide VBG cord-006252-cbelsymu 344 61 home home NN cord-006252-cbelsymu 344 62 care care NN cord-006252-cbelsymu 344 63 to to IN cord-006252-cbelsymu 344 64 high high JJ cord-006252-cbelsymu 344 65 risk risk NN cord-006252-cbelsymu 344 66 persons person NNS cord-006252-cbelsymu 344 67 provide provide VBP cord-006252-cbelsymu 344 68 educational educational JJ cord-006252-cbelsymu 344 69 materials material NNS cord-006252-cbelsymu 344 70 ; ; : cord-006252-cbelsymu 344 71 encourage encourage VB cord-006252-cbelsymu 344 72 vaccination vaccination NN cord-006252-cbelsymu 344 73 ; ; : cord-006252-cbelsymu 344 74 emphasise emphasise VB cord-006252-cbelsymu 344 75 to to TO cord-006252-cbelsymu 344 76 staff staff VB cord-006252-cbelsymu 344 77 in in IN cord-006252-cbelsymu 344 78 intensive intensive JJ cord-006252-cbelsymu 344 79 care care NN cord-006252-cbelsymu 344 80 units unit NNS cord-006252-cbelsymu 344 81 , , , cord-006252-cbelsymu 344 82 medical medical JJ cord-006252-cbelsymu 344 83 / / SYM cord-006252-cbelsymu 344 84 surgical surgical JJ cord-006252-cbelsymu 344 85 units unit NNS cord-006252-cbelsymu 344 86 , , , cord-006252-cbelsymu 344 87 employees employee NNS cord-006252-cbelsymu 344 88 in in IN cord-006252-cbelsymu 344 89 nursing nursing NN cord-006252-cbelsymu 344 90 homes home NNS cord-006252-cbelsymu 344 91 and and CC cord-006252-cbelsymu 344 92 long long JJ cord-006252-cbelsymu 344 93 term term NN cord-006252-cbelsymu 344 94 care care NN cord-006252-cbelsymu 344 95 facilities facility NNS cord-006252-cbelsymu 344 96 ; ; , cord-006252-cbelsymu 344 97 make make VB cord-006252-cbelsymu 344 98 vaccine vaccine NN cord-006252-cbelsymu 344 99 available available JJ cord-006252-cbelsymu 344 100 for for IN cord-006252-cbelsymu 344 101 all all DT cord-006252-cbelsymu 344 102 work work NN cord-006252-cbelsymu 344 103 shifts shift NNS cord-006252-cbelsymu 344 104 , , , cord-006252-cbelsymu 344 105 including include VBG cord-006252-cbelsymu 344 106 night night NN cord-006252-cbelsymu 344 107 and and CC cord-006252-cbelsymu 344 108 weekend weekend NN cord-006252-cbelsymu 344 109 . . . cord-006252-cbelsymu 345 1 Two two CD cord-006252-cbelsymu 345 2 antiviral antiviral JJ cord-006252-cbelsymu 345 3 agents agent NNS cord-006252-cbelsymu 345 4 are be VBP cord-006252-cbelsymu 345 5 effective effective JJ cord-006252-cbelsymu 345 6 in in IN cord-006252-cbelsymu 345 7 the the DT cord-006252-cbelsymu 345 8 prevention prevention NN cord-006252-cbelsymu 345 9 and and CC cord-006252-cbelsymu 345 10 treatment treatment NN cord-006252-cbelsymu 345 11 of of IN cord-006252-cbelsymu 345 12 influenza influenza NN cord-006252-cbelsymu 345 13 type type NN cord-006252-cbelsymu 345 14 A a DT cord-006252-cbelsymu 345 15 infections infection NNS cord-006252-cbelsymu 346 1 -amantadine -amantadine NNP cord-006252-cbelsymu 346 2 and and CC cord-006252-cbelsymu 346 3 rimantadine rimantadine NN cord-006252-cbelsymu 346 4 . . . cord-006252-cbelsymu 347 1 Only only RB cord-006252-cbelsymu 347 2 amantadine amantadine NNP cord-006252-cbelsymu 347 3 is be VBZ cord-006252-cbelsymu 347 4 currently currently RB cord-006252-cbelsymu 347 5 available available JJ cord-006252-cbelsymu 347 6 commercially commercially RB cord-006252-cbelsymu 347 7 in in IN cord-006252-cbelsymu 347 8 the the DT cord-006252-cbelsymu 347 9 United United NNP cord-006252-cbelsymu 347 10 States States NNP cord-006252-cbelsymu 347 11 . . . cord-006252-cbelsymu 348 1 It -PRON- PRP cord-006252-cbelsymu 348 2 has have VBZ cord-006252-cbelsymu 348 3 no no DT cord-006252-cbelsymu 348 4 effect effect NN cord-006252-cbelsymu 348 5 against against IN cord-006252-cbelsymu 348 6 influenza influenza NN cord-006252-cbelsymu 348 7 type type NN cord-006252-cbelsymu 348 8 B B NNP cord-006252-cbelsymu 348 9 ( ( -LRB- cord-006252-cbelsymu 348 10 Douglas Douglas NNP cord-006252-cbelsymu 348 11 1990 1990 CD cord-006252-cbelsymu 348 12 ) ) -RRB- cord-006252-cbelsymu 348 13 . . . cord-006252-cbelsymu 349 1 The the DT cord-006252-cbelsymu 349 2 primary primary JJ cord-006252-cbelsymu 349 3 use use NN cord-006252-cbelsymu 349 4 of of IN cord-006252-cbelsymu 349 5 amantadine amantadine NNP cord-006252-cbelsymu 349 6 is be VBZ cord-006252-cbelsymu 349 7 in in IN cord-006252-cbelsymu 349 8 preventing prevent VBG cord-006252-cbelsymu 349 9 influenza influenza NN cord-006252-cbelsymu 349 10 A a DT cord-006252-cbelsymu 349 11 infection infection NN cord-006252-cbelsymu 349 12 . . . cord-006252-cbelsymu 350 1 Preventive preventive JJ cord-006252-cbelsymu 350 2 efficacy efficacy NN cord-006252-cbelsymu 350 3 varies vary VBZ cord-006252-cbelsymu 350 4 between between IN cord-006252-cbelsymu 350 5 50 50 CD cord-006252-cbelsymu 350 6 and and CC cord-006252-cbelsymu 350 7 over over IN cord-006252-cbelsymu 350 8 90 90 CD cord-006252-cbelsymu 350 9 % % NN cord-006252-cbelsymu 350 10 . . . cord-006252-cbelsymu 351 1 When when WRB cord-006252-cbelsymu 351 2 influenza influenza NN cord-006252-cbelsymu 351 3 A a NN cord-006252-cbelsymu 351 4 is be VBZ cord-006252-cbelsymu 351 5 in in IN cord-006252-cbelsymu 351 6 the the DT cord-006252-cbelsymu 351 7 community community NN cord-006252-cbelsymu 351 8 , , , cord-006252-cbelsymu 351 9 an an DT cord-006252-cbelsymu 351 10 unvaccinated unvaccinated JJ cord-006252-cbelsymu 351 11 elderly elderly JJ cord-006252-cbelsymu 351 12 person person NN cord-006252-cbelsymu 351 13 should should MD cord-006252-cbelsymu 351 14 receive receive VB cord-006252-cbelsymu 351 15 vaccine vaccine NN cord-006252-cbelsymu 351 16 plus plus CC cord-006252-cbelsymu 351 17 2 2 CD cord-006252-cbelsymu 351 18 weeks week NNS cord-006252-cbelsymu 351 19 of of IN cord-006252-cbelsymu 351 20 amantadine amantadine NNP cord-006252-cbelsymu 351 21 at at IN cord-006252-cbelsymu 351 22 a a DT cord-006252-cbelsymu 351 23 dose dose NN cord-006252-cbelsymu 351 24 of of IN cord-006252-cbelsymu 351 25 100 100 CD cord-006252-cbelsymu 351 26 mg mg NNP cord-006252-cbelsymu 351 27 / / SYM cord-006252-cbelsymu 351 28 day day NN cord-006252-cbelsymu 351 29 ( ( -LRB- cord-006252-cbelsymu 351 30 Nicholson Nicholson NNP cord-006252-cbelsymu 351 31 & & CC cord-006252-cbelsymu 351 32 Wiselka Wiselka NNP cord-006252-cbelsymu 351 33 1991 1991 CD cord-006252-cbelsymu 351 34 ) ) -RRB- cord-006252-cbelsymu 351 35 . . . cord-006252-cbelsymu 352 1 Amantadine Amantadine NNP cord-006252-cbelsymu 352 2 does do VBZ cord-006252-cbelsymu 352 3 not not RB cord-006252-cbelsymu 352 4 interfere interfere VB cord-006252-cbelsymu 352 5 with with IN cord-006252-cbelsymu 352 6 the the DT cord-006252-cbelsymu 352 7 immune immune JJ cord-006252-cbelsymu 352 8 response response NN cord-006252-cbelsymu 352 9 to to IN cord-006252-cbelsymu 352 10 vaccine vaccine NN cord-006252-cbelsymu 352 11 , , , cord-006252-cbelsymu 352 12 and and CC cord-006252-cbelsymu 352 13 after after IN cord-006252-cbelsymu 352 14 2 2 CD cord-006252-cbelsymu 352 15 weeks week NNS cord-006252-cbelsymu 352 16 the the DT cord-006252-cbelsymu 352 17 vaccine vaccine NN cord-006252-cbelsymu 352 18 - - HYPH cord-006252-cbelsymu 352 19 induced induce VBN cord-006252-cbelsymu 352 20 immune immune JJ cord-006252-cbelsymu 352 21 response response NN cord-006252-cbelsymu 352 22 should should MD cord-006252-cbelsymu 352 23 be be VB cord-006252-cbelsymu 352 24 sufficient sufficient JJ cord-006252-cbelsymu 352 25 to to TO cord-006252-cbelsymu 352 26 prevent prevent VB cord-006252-cbelsymu 352 27 influenza influenza NN cord-006252-cbelsymu 352 28 . . . cord-006252-cbelsymu 353 1 Amantadine Amantadine NNP cord-006252-cbelsymu 353 2 treatment treatment NN cord-006252-cbelsymu 353 3 should should MD cord-006252-cbelsymu 353 4 not not RB cord-006252-cbelsymu 353 5 be be VB cord-006252-cbelsymu 353 6 stopped stop VBN cord-006252-cbelsymu 353 7 if if IN cord-006252-cbelsymu 353 8 the the DT cord-006252-cbelsymu 353 9 high high JJ cord-006252-cbelsymu 353 10 risk risk NN cord-006252-cbelsymu 353 11 person person NN cord-006252-cbelsymu 353 12 can can MD cord-006252-cbelsymu 353 13 not not RB cord-006252-cbelsymu 353 14 be be VB cord-006252-cbelsymu 353 15 vaccinated vaccinate VBN cord-006252-cbelsymu 353 16 or or CC cord-006252-cbelsymu 353 17 is be VBZ cord-006252-cbelsymu 353 18 immunodeficient immunodeficient JJ cord-006252-cbelsymu 353 19 . . . cord-006252-cbelsymu 354 1 It -PRON- PRP cord-006252-cbelsymu 354 2 should should MD cord-006252-cbelsymu 354 3 be be VB cord-006252-cbelsymu 354 4 continued continue VBN cord-006252-cbelsymu 354 5 for for IN cord-006252-cbelsymu 354 6 as as RB cord-006252-cbelsymu 354 7 long long RB cord-006252-cbelsymu 354 8 as as IN cord-006252-cbelsymu 354 9 influenza influenza NN cord-006252-cbelsymu 354 10 is be VBZ cord-006252-cbelsymu 354 11 epidemic epidemic NN cord-006252-cbelsymu 354 12 -usually -usually RB cord-006252-cbelsymu 354 13 about about RB cord-006252-cbelsymu 354 14 5 5 CD cord-006252-cbelsymu 354 15 to to TO cord-006252-cbelsymu 354 16 6 6 CD cord-006252-cbelsymu 354 17 weeks week NNS cord-006252-cbelsymu 354 18 . . . cord-006252-cbelsymu 355 1 Amantadine Amantadine NNP cord-006252-cbelsymu 355 2 has have VBZ cord-006252-cbelsymu 355 3 also also RB cord-006252-cbelsymu 355 4 been be VBN cord-006252-cbelsymu 355 5 used use VBN cord-006252-cbelsymu 355 6 for for IN cord-006252-cbelsymu 355 7 the the DT cord-006252-cbelsymu 355 8 treatment treatment NN cord-006252-cbelsymu 355 9 of of IN cord-006252-cbelsymu 355 10 influenza influenza NN cord-006252-cbelsymu 355 11 A. a. NN cord-006252-cbelsymu 356 1 When when WRB cord-006252-cbelsymu 356 2 the the DT cord-006252-cbelsymu 356 3 drug drug NN cord-006252-cbelsymu 356 4 is be VBZ cord-006252-cbelsymu 356 5 started start VBN cord-006252-cbelsymu 356 6 within within IN cord-006252-cbelsymu 356 7 48 48 CD cord-006252-cbelsymu 356 8 hours hour NNS cord-006252-cbelsymu 356 9 of of IN cord-006252-cbelsymu 356 10 the the DT cord-006252-cbelsymu 356 11 onset onset NN cord-006252-cbelsymu 356 12 of of IN cord-006252-cbelsymu 356 13 illness illness NN cord-006252-cbelsymu 356 14 it -PRON- PRP cord-006252-cbelsymu 356 15 produces produce VBZ cord-006252-cbelsymu 356 16 Prevention Prevention NNP cord-006252-cbelsymu 356 17 and and CC cord-006252-cbelsymu 356 18 Treatment Treatment NNP cord-006252-cbelsymu 356 19 of of IN cord-006252-cbelsymu 356 20 Influenza Influenza NNP cord-006252-cbelsymu 356 21 tolerated tolerate VBD cord-006252-cbelsymu 356 22 . . . cord-006252-cbelsymu 357 1 For for IN cord-006252-cbelsymu 357 2 example example NN cord-006252-cbelsymu 357 3 , , , cord-006252-cbelsymu 357 4 Margolis Margolis NNP cord-006252-cbelsymu 357 5 et et NNP cord-006252-cbelsymu 357 6 al al NNP cord-006252-cbelsymu 357 7 . . . cord-006252-cbelsymu 358 1 ( ( -LRB- cord-006252-cbelsymu 358 2 1990a 1990a CD cord-006252-cbelsymu 358 3 , , , cord-006252-cbelsymu 358 4 b b LS cord-006252-cbelsymu 358 5 ) ) -RRB- cord-006252-cbelsymu 358 6 reported report VBD cord-006252-cbelsymu 358 7 that that IN cord-006252-cbelsymu 358 8 in in IN cord-006252-cbelsymu 358 9 elderly elderly JJ cord-006252-cbelsymu 358 10 chronically chronically RB cord-006252-cbelsymu 358 11 ill ill JJ cord-006252-cbelsymu 358 12 patients patient NNS cord-006252-cbelsymu 358 13 fever fever NN cord-006252-cbelsymu 358 14 and and CC cord-006252-cbelsymu 358 15 significant significant JJ cord-006252-cbelsymu 358 16 disability disability NN cord-006252-cbelsymu 358 17 could could MD cord-006252-cbelsymu 358 18 not not RB cord-006252-cbelsymu 358 19 be be VB cord-006252-cbelsymu 358 20 attributed attribute VBN cord-006252-cbelsymu 358 21 to to IN cord-006252-cbelsymu 358 22 the the DT cord-006252-cbelsymu 358 23 vaccine vaccine NN cord-006252-cbelsymu 358 24 compared compare VBN cord-006252-cbelsymu 358 25 to to IN cord-006252-cbelsymu 358 26 a a DT cord-006252-cbelsymu 358 27 control control NN cord-006252-cbelsymu 358 28 group group NN cord-006252-cbelsymu 358 29 . . . cord-006252-cbelsymu 359 1 A a DT cord-006252-cbelsymu 359 2 flu flu NN cord-006252-cbelsymu 359 3 - - HYPH cord-006252-cbelsymu 359 4 like like JJ cord-006252-cbelsymu 359 5 illness illness NN cord-006252-cbelsymu 359 6 , , , cord-006252-cbelsymu 359 7 however however RB cord-006252-cbelsymu 359 8 , , , cord-006252-cbelsymu 359 9 was be VBD cord-006252-cbelsymu 359 10 attributable attributable JJ cord-006252-cbelsymu 359 11 to to IN cord-006252-cbelsymu 359 12 vaccine vaccine NN cord-006252-cbelsymu 359 13 in in IN cord-006252-cbelsymu 359 14 5.5 5.5 CD cord-006252-cbelsymu 359 15 % % NN cord-006252-cbelsymu 359 16 . . . cord-006252-cbelsymu 360 1 They -PRON- PRP cord-006252-cbelsymu 360 2 concluded conclude VBD cord-006252-cbelsymu 360 3 that that IN cord-006252-cbelsymu 360 4 the the DT cord-006252-cbelsymu 360 5 overall overall JJ cord-006252-cbelsymu 360 6 frequency frequency NN cord-006252-cbelsymu 360 7 of of IN cord-006252-cbelsymu 360 8 adverse adverse JJ cord-006252-cbelsymu 360 9 effects effect NNS cord-006252-cbelsymu 360 10 was be VBD cord-006252-cbelsymu 360 11 low low JJ cord-006252-cbelsymu 360 12 . . . cord-006252-cbelsymu 361 1 Another another DT cord-006252-cbelsymu 361 2 area area NN cord-006252-cbelsymu 361 3 of of IN cord-006252-cbelsymu 361 4 concern concern NN cord-006252-cbelsymu 361 5 is be VBZ cord-006252-cbelsymu 361 6 the the DT cord-006252-cbelsymu 361 7 effect effect NN cord-006252-cbelsymu 361 8 of of IN cord-006252-cbelsymu 361 9 vaccine vaccine NN cord-006252-cbelsymu 361 10 on on IN cord-006252-cbelsymu 361 11 drug drug NN cord-006252-cbelsymu 361 12 metabolism metabolism NN cord-006252-cbelsymu 361 13 . . . cord-006252-cbelsymu 362 1 The the DT cord-006252-cbelsymu 362 2 mechanism mechanism NN cord-006252-cbelsymu 362 3 postulated postulate VBN cord-006252-cbelsymu 362 4 is be VBZ cord-006252-cbelsymu 362 5 vaccine vaccine NN cord-006252-cbelsymu 362 6 suppression suppression NN cord-006252-cbelsymu 362 7 of of IN cord-006252-cbelsymu 362 8 oxidative oxidative JJ cord-006252-cbelsymu 362 9 hepatic hepatic JJ cord-006252-cbelsymu 362 10 metabolism metabolism NN cord-006252-cbelsymu 362 11 . . . cord-006252-cbelsymu 363 1 Interferon interferon NN cord-006252-cbelsymu 363 2 production production NN cord-006252-cbelsymu 363 3 induced induce VBN cord-006252-cbelsymu 363 4 by by IN cord-006252-cbelsymu 363 5 vaccination vaccination NN cord-006252-cbelsymu 363 6 is be VBZ cord-006252-cbelsymu 363 7 supposed suppose VBN cord-006252-cbelsymu 363 8 to to TO cord-006252-cbelsymu 363 9 block block VB cord-006252-cbelsymu 363 10 the the DT cord-006252-cbelsymu 363 11 oxidative oxidative JJ cord-006252-cbelsymu 363 12 cytochrome cytochrome NN cord-006252-cbelsymu 363 13 P450 p450 NN cord-006252-cbelsymu 363 14 system system NN cord-006252-cbelsymu 363 15 , , , cord-006252-cbelsymu 363 16 resulting result VBG cord-006252-cbelsymu 363 17 in in IN cord-006252-cbelsymu 363 18 accumulation accumulation NN cord-006252-cbelsymu 363 19 of of IN cord-006252-cbelsymu 363 20 certain certain JJ cord-006252-cbelsymu 363 21 drugs drug NNS cord-006252-cbelsymu 363 22 . . . cord-006252-cbelsymu 364 1 Metabolism metabolism NN cord-006252-cbelsymu 364 2 of of IN cord-006252-cbelsymu 364 3 theophylline theophylline NN cord-006252-cbelsymu 364 4 , , , cord-006252-cbelsymu 364 5 chlordiazepoxide chlordiazepoxide NN cord-006252-cbelsymu 364 6 , , , cord-006252-cbelsymu 364 7 lorazepam lorazepam NN cord-006252-cbelsymu 364 8 , , , cord-006252-cbelsymu 364 9 warfarin warfarin NN cord-006252-cbelsymu 364 10 , , , cord-006252-cbelsymu 364 11 phenytoin phenytoin NN cord-006252-cbelsymu 364 12 and and CC cord-006252-cbelsymu 364 13 phenobarbital phenobarbital NN cord-006252-cbelsymu 364 14 ( ( -LRB- cord-006252-cbelsymu 364 15 phenobarbitone phenobarbitone NNP cord-006252-cbelsymu 364 16 ) ) -RRB- cord-006252-cbelsymu 364 17 has have VBZ cord-006252-cbelsymu 364 18 been be VBN cord-006252-cbelsymu 364 19 studied study VBN cord-006252-cbelsymu 364 20 , , , cord-006252-cbelsymu 364 21 with with IN cord-006252-cbelsymu 364 22 variable variable JJ cord-006252-cbelsymu 364 23 results result NNS cord-006252-cbelsymu 364 24 . . . cord-006252-cbelsymu 365 1 For for IN cord-006252-cbelsymu 365 2 theophylline theophylline NN cord-006252-cbelsymu 365 3 , , , cord-006252-cbelsymu 365 4 in in IN cord-006252-cbelsymu 365 5 particular particular JJ cord-006252-cbelsymu 365 6 , , , cord-006252-cbelsymu 365 7 most most JJS cord-006252-cbelsymu 365 8 studies study NNS cord-006252-cbelsymu 365 9 seem seem VBP cord-006252-cbelsymu 365 10 to to TO cord-006252-cbelsymu 365 11 indicate indicate VB cord-006252-cbelsymu 365 12 that that IN cord-006252-cbelsymu 365 13 the the DT cord-006252-cbelsymu 365 14 effect effect NN cord-006252-cbelsymu 365 15 of of IN cord-006252-cbelsymu 365 16 vaccine vaccine NN cord-006252-cbelsymu 365 17 is be VBZ cord-006252-cbelsymu 365 18 minor minor JJ cord-006252-cbelsymu 365 19 . . . cord-006252-cbelsymu 366 1 Less Less JJR cord-006252-cbelsymu 366 2 than than IN cord-006252-cbelsymu 366 3 30 30 CD cord-006252-cbelsymu 366 4 % % NN cord-006252-cbelsymu 366 5 of of IN cord-006252-cbelsymu 366 6 high high JJ cord-006252-cbelsymu 366 7 risk risk NN cord-006252-cbelsymu 366 8 persons person NNS cord-006252-cbelsymu 366 9 are be VBP cord-006252-cbelsymu 366 10 vaccinated vaccinate VBN cord-006252-cbelsymu 366 11 annually annually RB cord-006252-cbelsymu 366 12 . . . cord-006252-cbelsymu 367 1 Consequently consequently RB cord-006252-cbelsymu 367 2 many many JJ cord-006252-cbelsymu 367 3 studies study NNS cord-006252-cbelsymu 367 4 have have VBP cord-006252-cbelsymu 367 5 been be VBN cord-006252-cbelsymu 367 6 undertaken undertake VBN cord-006252-cbelsymu 367 7 to to TO cord-006252-cbelsymu 367 8 determine determine VB cord-006252-cbelsymu 367 9 the the DT cord-006252-cbelsymu 367 10 best good JJS cord-006252-cbelsymu 367 11 strategies strategy NNS cord-006252-cbelsymu 367 12 for for IN cord-006252-cbelsymu 367 13 immunising immunise VBG cord-006252-cbelsymu 367 14 appropriate appropriate JJ cord-006252-cbelsymu 367 15 groups group NNS cord-006252-cbelsymu 367 16 . . . cord-006252-cbelsymu 368 1 The the DT cord-006252-cbelsymu 368 2 current current JJ cord-006252-cbelsymu 368 3 strategies strategy NNS cord-006252-cbelsymu 368 4 for for IN cord-006252-cbelsymu 368 5 implementing implement VBG cord-006252-cbelsymu 368 6 the the DT cord-006252-cbelsymu 368 7 influenza influenza NN cord-006252-cbelsymu 368 8 vaccine vaccine NN cord-006252-cbelsymu 368 9 recommendations recommendation NNS cord-006252-cbelsymu 368 10 include include VBP cord-006252-cbelsymu 368 11 immunising immunise VBG cord-006252-cbelsymu 368 12 persons person NNS cord-006252-cbelsymu 368 13 in in IN cord-006252-cbelsymu 368 14 the the DT cord-006252-cbelsymu 368 15 following follow VBG cord-006252-cbelsymu 368 16 settings setting NNS cord-006252-cbelsymu 368 17 ( ( -LRB- cord-006252-cbelsymu 368 18 Recommendations Recommendations NNPS cord-006252-cbelsymu 368 19 of of IN cord-006252-cbelsymu 368 20 the the DT cord-006252-cbelsymu 368 21 Immunization Immunization NNP cord-006252-cbelsymu 368 22 Practices Practices NNPS cord-006252-cbelsymu 368 23 Advisory Advisory NNP cord-006252-cbelsymu 368 24 Committee Committee NNP cord-006252-cbelsymu 368 25 1990 1990 CD cord-006252-cbelsymu 368 26 ) ) -RRB- cord-006252-cbelsymu 368 27 . . . cord-006252-cbelsymu 369 1 1 1 LS cord-006252-cbelsymu 369 2 . . . cord-006252-cbelsymu 370 1 In in IN cord-006252-cbelsymu 370 2 outpatient outpatient NN cord-006252-cbelsymu 370 3 clinics clinic NNS cord-006252-cbelsymu 370 4 and and CC cord-006252-cbelsymu 370 5 physicians physician NNS cord-006252-cbelsymu 370 6 ' ' POS cord-006252-cbelsymu 370 7 offices office NNS cord-006252-cbelsymu 370 8 label label VBP cord-006252-cbelsymu 370 9 medical medical JJ cord-006252-cbelsymu 370 10 records record NNS cord-006252-cbelsymu 370 11 of of IN cord-006252-cbelsymu 370 12 high high JJ cord-006252-cbelsymu 370 13 risk risk NN cord-006252-cbelsymu 370 14 persons person NNS cord-006252-cbelsymu 370 15 ; ; : cord-006252-cbelsymu 370 16 use use VB cord-006252-cbelsymu 370 17 mail mail NN cord-006252-cbelsymu 370 18 or or CC cord-006252-cbelsymu 370 19 telephone telephone NN cord-006252-cbelsymu 370 20 reminders reminder NNS cord-006252-cbelsymu 370 21 ; ; : cord-006252-cbelsymu 370 22 begin begin VB cord-006252-cbelsymu 370 23 vaccinating vaccinate VBG cord-006252-cbelsymu 370 24 in in IN cord-006252-cbelsymu 370 25 September September NNP cord-006252-cbelsymu 370 26 ( ( -LRB- cord-006252-cbelsymu 370 27 Northern Northern NNP cord-006252-cbelsymu 370 28 Hemisphere Hemisphere NNP cord-006252-cbelsymu 370 29 ) ) -RRB- cord-006252-cbelsymu 370 30 and and CC cord-006252-cbelsymu 370 31 March March NNP cord-006252-cbelsymu 370 32 ( ( -LRB- cord-006252-cbelsymu 370 33 Southern Southern NNP cord-006252-cbelsymu 370 34 Hemisphere Hemisphere NNP cord-006252-cbelsymu 370 35 ) ) -RRB- cord-006252-cbelsymu 370 36 . . . cord-006252-cbelsymu 371 1 2 2 LS cord-006252-cbelsymu 371 2 . . . cord-006252-cbelsymu 372 1 In in IN cord-006252-cbelsymu 372 2 facilities facility NNS cord-006252-cbelsymu 372 3 providing provide VBG cord-006252-cbelsymu 372 4 episodic episodic JJ cord-006252-cbelsymu 372 5 or or CC cord-006252-cbelsymu 372 6 acute acute JJ cord-006252-cbelsymu 372 7 care care NN cord-006252-cbelsymu 372 8 ( ( -LRB- cord-006252-cbelsymu 372 9 e.g. e.g. RB cord-006252-cbelsymu 372 10 emergency emergency NN cord-006252-cbelsymu 372 11 rooms room NNS cord-006252-cbelsymu 372 12 , , , cord-006252-cbelsymu 372 13 walk walk NN cord-006252-cbelsymu 372 14 - - HYPH cord-006252-cbelsymu 372 15 in in RP cord-006252-cbelsymu 372 16 clinics clinic NNS cord-006252-cbelsymu 372 17 ) ) -RRB- cord-006252-cbelsymu 373 1 healthcare healthcare NN cord-006252-cbelsymu 373 2 providers provider NNS cord-006252-cbelsymu 373 3 be be VB cord-006252-cbelsymu 373 4 aware aware JJ cord-006252-cbelsymu 373 5 of of IN cord-006252-cbelsymu 373 6 high high JJ cord-006252-cbelsymu 373 7 risk risk NN cord-006252-cbelsymu 373 8 groups group NNS cord-006252-cbelsymu 373 9 ; ; : cord-006252-cbelsymu 373 10 provide provide VB cord-006252-cbelsymu 373 11 written write VBN cord-006252-cbelsymu 373 12 information information NN cord-006252-cbelsymu 373 13 in in IN cord-006252-cbelsymu 373 14 appropriate appropriate JJ cord-006252-cbelsymu 373 15 languages language NNS cord-006252-cbelsymu 373 16 . . . cord-006252-cbelsymu 374 1 3 3 LS cord-006252-cbelsymu 374 2 . . . cord-006252-cbelsymu 375 1 In in IN cord-006252-cbelsymu 375 2 nursing nursing NN cord-006252-cbelsymu 375 3 homes home NNS cord-006252-cbelsymu 375 4 and and CC cord-006252-cbelsymu 375 5 other other JJ cord-006252-cbelsymu 375 6 residential residential JJ cord-006252-cbelsymu 375 7 long long JJ cord-006252-cbelsymu 375 8 term term NN cord-006252-cbelsymu 375 9 care care NN cord-006252-cbelsymu 375 10 facilities facility NNS cord-006252-cbelsymu 375 11 vaccinate vaccinate VBP cord-006252-cbelsymu 375 12 all all DT cord-006252-cbelsymu 375 13 residents resident NNS cord-006252-cbelsymu 375 14 with with IN cord-006252-cbelsymu 375 15 the the DT cord-006252-cbelsymu 375 16 prior prior JJ cord-006252-cbelsymu 375 17 aggreement aggreement NN cord-006252-cbelsymu 375 18 of of IN cord-006252-cbelsymu 375 19 attending attend VBG cord-006252-cbelsymu 375 20 physicians physician NNS cord-006252-cbelsymu 375 21 ; ; : cord-006252-cbelsymu 375 22 do do VBP cord-006252-cbelsymu 375 23 not not RB cord-006252-cbelsymu 375 24 require require VB cord-006252-cbelsymu 375 25 individual individual JJ cord-006252-cbelsymu 375 26 physician physician NN cord-006252-cbelsymu 375 27 orders order NNS cord-006252-cbelsymu 375 28 ; ; : cord-006252-cbelsymu 375 29 obtain obtain VB cord-006252-cbelsymu 375 30 permission permission NN cord-006252-cbelsymu 375 31 for for IN cord-006252-cbelsymu 375 32 vaccination vaccination NN cord-006252-cbelsymu 375 33 on on IN cord-006252-cbelsymu 375 34 admission admission NN cord-006252-cbelsymu 375 35 to to IN cord-006252-cbelsymu 375 36 facility facility NN cord-006252-cbelsymu 375 37 . . . cord-006252-cbelsymu 376 1 437 437 CD cord-006252-cbelsymu 376 2 4 4 CD cord-006252-cbelsymu 376 3 . . . cord-006252-cbelsymu 377 1 In in IN cord-006252-cbelsymu 377 2 acute acute JJ cord-006252-cbelsymu 377 3 - - HYPH cord-006252-cbelsymu 377 4 care care NN cord-006252-cbelsymu 377 5 hospitals hospital NNS cord-006252-cbelsymu 377 6 encourage encourage VBP cord-006252-cbelsymu 377 7 vaccination vaccination NN cord-006252-cbelsymu 377 8 before before IN cord-006252-cbelsymu 377 9 discharge discharge NN cord-006252-cbelsymu 377 10 between between IN cord-006252-cbelsymu 377 11 September September NNP cord-006252-cbelsymu 377 12 and and CC cord-006252-cbelsymu 377 13 April April NNP cord-006252-cbelsymu 377 14 ( ( -LRB- cord-006252-cbelsymu 377 15 Northern Northern NNP cord-006252-cbelsymu 377 16 Hemisphere Hemisphere NNP cord-006252-cbelsymu 377 17 ) ) -RRB- cord-006252-cbelsymu 377 18 , , , cord-006252-cbelsymu 377 19 and and CC cord-006252-cbelsymu 377 20 March March NNP cord-006252-cbelsymu 377 21 to to IN cord-006252-cbelsymu 377 22 August August NNP cord-006252-cbelsymu 377 23 ( ( -LRB- cord-006252-cbelsymu 377 24 Southern Southern NNP cord-006252-cbelsymu 377 25 Hemisphere Hemisphere NNP cord-006252-cbelsymu 377 26 ) ) -RRB- cord-006252-cbelsymu 377 27 of of IN cord-006252-cbelsymu 377 28 all all DT cord-006252-cbelsymu 377 29 persons person NNS cord-006252-cbelsymu 377 30 aged age VBN cord-006252-cbelsymu 377 31 65 65 CD cord-006252-cbelsymu 377 32 years year NNS cord-006252-cbelsymu 377 33 or or CC cord-006252-cbelsymu 377 34 over over RB cord-006252-cbelsymu 377 35 , , , cord-006252-cbelsymu 377 36 or or CC cord-006252-cbelsymu 377 37 with with IN cord-006252-cbelsymu 377 38 high high JJ cord-006252-cbelsymu 377 39 risk risk NN cord-006252-cbelsymu 377 40 conditions condition NNS cord-006252-cbelsymu 377 41 at at IN cord-006252-cbelsymu 377 42 any any DT cord-006252-cbelsymu 377 43 age age NN cord-006252-cbelsymu 377 44 . . . cord-006252-cbelsymu 378 1 5 5 LS cord-006252-cbelsymu 378 2 . . . cord-006252-cbelsymu 379 1 In in IN cord-006252-cbelsymu 379 2 outpatient outpatient NN cord-006252-cbelsymu 379 3 facilities facility NNS cord-006252-cbelsymu 379 4 providing provide VBG cord-006252-cbelsymu 379 5 continuing continue VBG cord-006252-cbelsymu 379 6 care care NN cord-006252-cbelsymu 379 7 to to IN cord-006252-cbelsymu 379 8 high high JJ cord-006252-cbelsymu 379 9 risk risk NN cord-006252-cbelsymu 379 10 patients patient NNS cord-006252-cbelsymu 379 11 ( ( -LRB- cord-006252-cbelsymu 379 12 e.g. e.g. IN cord-006252-cbelsymu 379 13 haemodialysis haemodialysis NNP cord-006252-cbelsymu 379 14 centres centre NNS cord-006252-cbelsymu 379 15 , , , cord-006252-cbelsymu 379 16 hospital hospital NN cord-006252-cbelsymu 379 17 speciality speciality NN cord-006252-cbelsymu 379 18 care care NN cord-006252-cbelsymu 379 19 clinics clinic NNS cord-006252-cbelsymu 379 20 , , , cord-006252-cbelsymu 379 21 outpatient outpatient NN cord-006252-cbelsymu 379 22 rehabilitation rehabilitation NN cord-006252-cbelsymu 379 23 programmes programme NNS cord-006252-cbelsymu 379 24 ) ) -RRB- cord-006252-cbelsymu 379 25 ; ; : cord-006252-cbelsymu 379 26 facilities facility NNS cord-006252-cbelsymu 379 27 providing provide VBG cord-006252-cbelsymu 379 28 services service NNS cord-006252-cbelsymu 379 29 to to IN cord-006252-cbelsymu 379 30 people people NNS cord-006252-cbelsymu 379 31 65 65 CD cord-006252-cbelsymu 379 32 years year NNS cord-006252-cbelsymu 379 33 and and CC cord-006252-cbelsymu 379 34 older old JJR cord-006252-cbelsymu 379 35 ( ( -LRB- cord-006252-cbelsymu 379 36 e.g. e.g. IN cord-006252-cbelsymu 379 37 retirement retirement NN cord-006252-cbelsymu 379 38 communities community NNS cord-006252-cbelsymu 379 39 , , , cord-006252-cbelsymu 379 40 recreation recreation NN cord-006252-cbelsymu 379 41 centres centre NNS cord-006252-cbelsymu 379 42 ) ) -RRB- cord-006252-cbelsymu 379 43 ; ; : cord-006252-cbelsymu 379 44 clinics clinic NNS cord-006252-cbelsymu 379 45 and and CC cord-006252-cbelsymu 379 46 other other JJ cord-006252-cbelsymu 379 47 centres centre NNS cord-006252-cbelsymu 379 48 providing provide VBG cord-006252-cbelsymu 379 49 healthcare healthcare NN cord-006252-cbelsymu 379 50 for for IN cord-006252-cbelsymu 379 51 travellers traveller NNS cord-006252-cbelsymu 379 52 ; ; : cord-006252-cbelsymu 379 53 healthcare healthcare NN cord-006252-cbelsymu 379 54 workers worker NNS cord-006252-cbelsymu 379 55 , , , cord-006252-cbelsymu 379 56 visiting visit VBG cord-006252-cbelsymu 379 57 nurses nurse NNS cord-006252-cbelsymu 379 58 and and CC cord-006252-cbelsymu 379 59 others other NNS cord-006252-cbelsymu 379 60 providing provide VBG cord-006252-cbelsymu 379 61 home home NN cord-006252-cbelsymu 379 62 care care NN cord-006252-cbelsymu 379 63 to to IN cord-006252-cbelsymu 379 64 high high JJ cord-006252-cbelsymu 379 65 risk risk NN cord-006252-cbelsymu 379 66 persons person NNS cord-006252-cbelsymu 379 67 provide provide VBP cord-006252-cbelsymu 379 68 educational educational JJ cord-006252-cbelsymu 379 69 materials material NNS cord-006252-cbelsymu 379 70 ; ; : cord-006252-cbelsymu 379 71 encourage encourage VB cord-006252-cbelsymu 379 72 vaccination vaccination NN cord-006252-cbelsymu 379 73 ; ; : cord-006252-cbelsymu 379 74 emphasise emphasise VB cord-006252-cbelsymu 379 75 to to TO cord-006252-cbelsymu 379 76 staff staff VB cord-006252-cbelsymu 379 77 in in IN cord-006252-cbelsymu 379 78 intensive intensive JJ cord-006252-cbelsymu 379 79 care care NN cord-006252-cbelsymu 379 80 units unit NNS cord-006252-cbelsymu 379 81 , , , cord-006252-cbelsymu 379 82 medical medical JJ cord-006252-cbelsymu 379 83 / / SYM cord-006252-cbelsymu 379 84 surgical surgical JJ cord-006252-cbelsymu 379 85 units unit NNS cord-006252-cbelsymu 379 86 , , , cord-006252-cbelsymu 379 87 employees employee NNS cord-006252-cbelsymu 379 88 in in IN cord-006252-cbelsymu 379 89 nursing nursing NN cord-006252-cbelsymu 379 90 homes home NNS cord-006252-cbelsymu 379 91 and and CC cord-006252-cbelsymu 379 92 long long JJ cord-006252-cbelsymu 379 93 term term NN cord-006252-cbelsymu 379 94 care care NN cord-006252-cbelsymu 379 95 facilities facility NNS cord-006252-cbelsymu 379 96 ; ; , cord-006252-cbelsymu 379 97 make make VB cord-006252-cbelsymu 379 98 vaccine vaccine NN cord-006252-cbelsymu 379 99 available available JJ cord-006252-cbelsymu 379 100 for for IN cord-006252-cbelsymu 379 101 all all DT cord-006252-cbelsymu 379 102 work work NN cord-006252-cbelsymu 379 103 shifts shift NNS cord-006252-cbelsymu 379 104 , , , cord-006252-cbelsymu 379 105 including include VBG cord-006252-cbelsymu 379 106 night night NN cord-006252-cbelsymu 379 107 and and CC cord-006252-cbelsymu 379 108 weekend weekend NN cord-006252-cbelsymu 379 109 . . . cord-006252-cbelsymu 380 1 Two two CD cord-006252-cbelsymu 380 2 antiviral antiviral JJ cord-006252-cbelsymu 380 3 agents agent NNS cord-006252-cbelsymu 380 4 are be VBP cord-006252-cbelsymu 380 5 effective effective JJ cord-006252-cbelsymu 380 6 in in IN cord-006252-cbelsymu 380 7 the the DT cord-006252-cbelsymu 380 8 prevention prevention NN cord-006252-cbelsymu 380 9 and and CC cord-006252-cbelsymu 380 10 treatment treatment NN cord-006252-cbelsymu 380 11 of of IN cord-006252-cbelsymu 380 12 influenza influenza NN cord-006252-cbelsymu 380 13 type type NN cord-006252-cbelsymu 380 14 A a DT cord-006252-cbelsymu 380 15 infections infection NNS cord-006252-cbelsymu 381 1 -amantadine -amantadine NNP cord-006252-cbelsymu 381 2 and and CC cord-006252-cbelsymu 381 3 rimantadine rimantadine NN cord-006252-cbelsymu 381 4 . . . cord-006252-cbelsymu 382 1 Only only RB cord-006252-cbelsymu 382 2 amantadine amantadine NNP cord-006252-cbelsymu 382 3 is be VBZ cord-006252-cbelsymu 382 4 currently currently RB cord-006252-cbelsymu 382 5 available available JJ cord-006252-cbelsymu 382 6 commercially commercially RB cord-006252-cbelsymu 382 7 in in IN cord-006252-cbelsymu 382 8 the the DT cord-006252-cbelsymu 382 9 United United NNP cord-006252-cbelsymu 382 10 States States NNP cord-006252-cbelsymu 382 11 . . . cord-006252-cbelsymu 383 1 It -PRON- PRP cord-006252-cbelsymu 383 2 has have VBZ cord-006252-cbelsymu 383 3 no no DT cord-006252-cbelsymu 383 4 effect effect NN cord-006252-cbelsymu 383 5 against against IN cord-006252-cbelsymu 383 6 influenza influenza NN cord-006252-cbelsymu 383 7 type type NN cord-006252-cbelsymu 383 8 B B NNP cord-006252-cbelsymu 383 9 ( ( -LRB- cord-006252-cbelsymu 383 10 Douglas Douglas NNP cord-006252-cbelsymu 383 11 1990 1990 CD cord-006252-cbelsymu 383 12 ) ) -RRB- cord-006252-cbelsymu 383 13 . . . cord-006252-cbelsymu 384 1 The the DT cord-006252-cbelsymu 384 2 primary primary JJ cord-006252-cbelsymu 384 3 use use NN cord-006252-cbelsymu 384 4 of of IN cord-006252-cbelsymu 384 5 amantadine amantadine NNP cord-006252-cbelsymu 384 6 is be VBZ cord-006252-cbelsymu 384 7 in in IN cord-006252-cbelsymu 384 8 preventing prevent VBG cord-006252-cbelsymu 384 9 influenza influenza NN cord-006252-cbelsymu 384 10 A a DT cord-006252-cbelsymu 384 11 infection infection NN cord-006252-cbelsymu 384 12 . . . cord-006252-cbelsymu 385 1 Preventive preventive JJ cord-006252-cbelsymu 385 2 efficacy efficacy NN cord-006252-cbelsymu 385 3 varies vary VBZ cord-006252-cbelsymu 385 4 between between IN cord-006252-cbelsymu 385 5 50 50 CD cord-006252-cbelsymu 385 6 and and CC cord-006252-cbelsymu 385 7 over over IN cord-006252-cbelsymu 385 8 90 90 CD cord-006252-cbelsymu 385 9 % % NN cord-006252-cbelsymu 385 10 . . . cord-006252-cbelsymu 386 1 When when WRB cord-006252-cbelsymu 386 2 influenza influenza NN cord-006252-cbelsymu 386 3 A a NN cord-006252-cbelsymu 386 4 is be VBZ cord-006252-cbelsymu 386 5 in in IN cord-006252-cbelsymu 386 6 the the DT cord-006252-cbelsymu 386 7 community community NN cord-006252-cbelsymu 386 8 , , , cord-006252-cbelsymu 386 9 an an DT cord-006252-cbelsymu 386 10 unvaccinated unvaccinated JJ cord-006252-cbelsymu 386 11 elderly elderly JJ cord-006252-cbelsymu 386 12 person person NN cord-006252-cbelsymu 386 13 should should MD cord-006252-cbelsymu 386 14 receive receive VB cord-006252-cbelsymu 386 15 vaccine vaccine NN cord-006252-cbelsymu 386 16 plus plus CC cord-006252-cbelsymu 386 17 2 2 CD cord-006252-cbelsymu 386 18 weeks week NNS cord-006252-cbelsymu 386 19 of of IN cord-006252-cbelsymu 386 20 amantadine amantadine NNP cord-006252-cbelsymu 386 21 at at IN cord-006252-cbelsymu 386 22 a a DT cord-006252-cbelsymu 386 23 dose dose NN cord-006252-cbelsymu 386 24 of of IN cord-006252-cbelsymu 386 25 100 100 CD cord-006252-cbelsymu 386 26 mg mg NNP cord-006252-cbelsymu 386 27 / / SYM cord-006252-cbelsymu 386 28 day day NN cord-006252-cbelsymu 386 29 ( ( -LRB- cord-006252-cbelsymu 386 30 Nicholson Nicholson NNP cord-006252-cbelsymu 386 31 & & CC cord-006252-cbelsymu 386 32 Wiselka Wiselka NNP cord-006252-cbelsymu 386 33 1991 1991 CD cord-006252-cbelsymu 386 34 ) ) -RRB- cord-006252-cbelsymu 386 35 . . . cord-006252-cbelsymu 387 1 Amantadine Amantadine NNP cord-006252-cbelsymu 387 2 does do VBZ cord-006252-cbelsymu 387 3 not not RB cord-006252-cbelsymu 387 4 interfere interfere VB cord-006252-cbelsymu 387 5 with with IN cord-006252-cbelsymu 387 6 the the DT cord-006252-cbelsymu 387 7 immune immune JJ cord-006252-cbelsymu 387 8 response response NN cord-006252-cbelsymu 387 9 to to IN cord-006252-cbelsymu 387 10 vaccine vaccine NN cord-006252-cbelsymu 387 11 , , , cord-006252-cbelsymu 387 12 and and CC cord-006252-cbelsymu 387 13 after after IN cord-006252-cbelsymu 387 14 2 2 CD cord-006252-cbelsymu 387 15 weeks week NNS cord-006252-cbelsymu 387 16 the the DT cord-006252-cbelsymu 387 17 vaccine vaccine NN cord-006252-cbelsymu 387 18 - - HYPH cord-006252-cbelsymu 387 19 induced induce VBN cord-006252-cbelsymu 387 20 immune immune JJ cord-006252-cbelsymu 387 21 response response NN cord-006252-cbelsymu 387 22 should should MD cord-006252-cbelsymu 387 23 be be VB cord-006252-cbelsymu 387 24 sufficient sufficient JJ cord-006252-cbelsymu 387 25 to to TO cord-006252-cbelsymu 387 26 prevent prevent VB cord-006252-cbelsymu 387 27 influenza influenza NN cord-006252-cbelsymu 387 28 . . . cord-006252-cbelsymu 388 1 Amantadine Amantadine NNP cord-006252-cbelsymu 388 2 treatment treatment NN cord-006252-cbelsymu 388 3 should should MD cord-006252-cbelsymu 388 4 not not RB cord-006252-cbelsymu 388 5 be be VB cord-006252-cbelsymu 388 6 stopped stop VBN cord-006252-cbelsymu 388 7 if if IN cord-006252-cbelsymu 388 8 the the DT cord-006252-cbelsymu 388 9 high high JJ cord-006252-cbelsymu 388 10 risk risk NN cord-006252-cbelsymu 388 11 person person NN cord-006252-cbelsymu 388 12 can can MD cord-006252-cbelsymu 388 13 not not RB cord-006252-cbelsymu 388 14 be be VB cord-006252-cbelsymu 388 15 vaccinated vaccinate VBN cord-006252-cbelsymu 388 16 or or CC cord-006252-cbelsymu 388 17 is be VBZ cord-006252-cbelsymu 388 18 immunodeficient immunodeficient JJ cord-006252-cbelsymu 388 19 . . . cord-006252-cbelsymu 389 1 It -PRON- PRP cord-006252-cbelsymu 389 2 should should MD cord-006252-cbelsymu 389 3 be be VB cord-006252-cbelsymu 389 4 continued continue VBN cord-006252-cbelsymu 389 5 for for IN cord-006252-cbelsymu 389 6 as as RB cord-006252-cbelsymu 389 7 long long RB cord-006252-cbelsymu 389 8 as as IN cord-006252-cbelsymu 389 9 influenza influenza NN cord-006252-cbelsymu 389 10 is be VBZ cord-006252-cbelsymu 389 11 epidemic epidemic NN cord-006252-cbelsymu 389 12 -usually -usually RB cord-006252-cbelsymu 389 13 about about RB cord-006252-cbelsymu 389 14 5 5 CD cord-006252-cbelsymu 389 15 to to TO cord-006252-cbelsymu 389 16 6 6 CD cord-006252-cbelsymu 389 17 weeks week NNS cord-006252-cbelsymu 389 18 . . . cord-006252-cbelsymu 390 1 Amantadine Amantadine NNP cord-006252-cbelsymu 390 2 has have VBZ cord-006252-cbelsymu 390 3 also also RB cord-006252-cbelsymu 390 4 been be VBN cord-006252-cbelsymu 390 5 used use VBN cord-006252-cbelsymu 390 6 for for IN cord-006252-cbelsymu 390 7 the the DT cord-006252-cbelsymu 390 8 treatment treatment NN cord-006252-cbelsymu 390 9 of of IN cord-006252-cbelsymu 390 10 influenza influenza NN cord-006252-cbelsymu 390 11 A. a. NN cord-006252-cbelsymu 391 1 When when WRB cord-006252-cbelsymu 391 2 the the DT cord-006252-cbelsymu 391 3 drug drug NN cord-006252-cbelsymu 391 4 is be VBZ cord-006252-cbelsymu 391 5 started start VBN cord-006252-cbelsymu 391 6 within within IN cord-006252-cbelsymu 391 7 48 48 CD cord-006252-cbelsymu 391 8 hours hour NNS cord-006252-cbelsymu 391 9 of of IN cord-006252-cbelsymu 391 10 the the DT cord-006252-cbelsymu 391 11 onset onset NN cord-006252-cbelsymu 391 12 of of IN cord-006252-cbelsymu 391 13 illness illness NN cord-006252-cbelsymu 391 14 it -PRON- PRP cord-006252-cbelsymu 391 15 produces produce VBZ cord-006252-cbelsymu 391 16 a a DT cord-006252-cbelsymu 391 17 therapeutic therapeutic JJ cord-006252-cbelsymu 391 18 effect effect NN cord-006252-cbelsymu 391 19 . . . cord-006252-cbelsymu 392 1 The the DT cord-006252-cbelsymu 392 2 duration duration NN cord-006252-cbelsymu 392 3 of of IN cord-006252-cbelsymu 392 4 illness illness NN cord-006252-cbelsymu 392 5 decreases decrease VBZ cord-006252-cbelsymu 392 6 by by IN cord-006252-cbelsymu 392 7 50 50 CD cord-006252-cbelsymu 392 8 % % NN cord-006252-cbelsymu 392 9 , , , cord-006252-cbelsymu 392 10 virus virus NN cord-006252-cbelsymu 392 11 shedding shed VBG cord-006252-cbelsymu 392 12 decreases decrease VBZ cord-006252-cbelsymu 392 13 more more RBR cord-006252-cbelsymu 392 14 rapidly rapidly RB cord-006252-cbelsymu 392 15 , , , cord-006252-cbelsymu 392 16 and and CC cord-006252-cbelsymu 392 17 peripheral peripheral JJ cord-006252-cbelsymu 392 18 airway airway NN cord-006252-cbelsymu 392 19 resistance resistance NN cord-006252-cbelsymu 392 20 is be VBZ cord-006252-cbelsymu 392 21 reduced reduce VBN cord-006252-cbelsymu 392 22 faster fast RBR cord-006252-cbelsymu 392 23 . . . cord-006252-cbelsymu 393 1 Serum serum NN cord-006252-cbelsymu 393 2 antibody antibody NN cord-006252-cbelsymu 393 3 still still RB cord-006252-cbelsymu 393 4 develops develop VBZ cord-006252-cbelsymu 393 5 despite despite IN cord-006252-cbelsymu 393 6 the the DT cord-006252-cbelsymu 393 7 use use NN cord-006252-cbelsymu 393 8 of of IN cord-006252-cbelsymu 393 9 amantadine amantadine NNP cord-006252-cbelsymu 393 10 . . . cord-006252-cbelsymu 394 1 Amantadine Amantadine NNP cord-006252-cbelsymu 394 2 treatment treatment NN cord-006252-cbelsymu 394 3 for for IN cord-006252-cbelsymu 394 4 the the DT cord-006252-cbelsymu 394 5 acute acute JJ cord-006252-cbelsymu 394 6 illness illness NN cord-006252-cbelsymu 394 7 should should MD cord-006252-cbelsymu 394 8 be be VB cord-006252-cbelsymu 394 9 continued continue VBN cord-006252-cbelsymu 394 10 for for IN cord-006252-cbelsymu 394 11 5 5 CD cord-006252-cbelsymu 394 12 days day NNS cord-006252-cbelsymu 394 13 . . . cord-006252-cbelsymu 395 1 Studies study NNS cord-006252-cbelsymu 395 2 on on IN cord-006252-cbelsymu 395 3 the the DT cord-006252-cbelsymu 395 4 therapeutic therapeutic JJ cord-006252-cbelsymu 395 5 efficacy efficacy NN cord-006252-cbelsymu 395 6 of of IN cord-006252-cbelsymu 395 7 amantadine amantadine NNP cord-006252-cbelsymu 395 8 have have VBP cord-006252-cbelsymu 395 9 been be VBN cord-006252-cbelsymu 395 10 done do VBN cord-006252-cbelsymu 395 11 in in IN cord-006252-cbelsymu 395 12 healthy healthy JJ cord-006252-cbelsymu 395 13 adults adult NNS cord-006252-cbelsymu 395 14 ; ; : cord-006252-cbelsymu 395 15 there there EX cord-006252-cbelsymu 395 16 are be VBP cord-006252-cbelsymu 395 17 no no DT cord-006252-cbelsymu 395 18 data data NN cord-006252-cbelsymu 395 19 on on IN cord-006252-cbelsymu 395 20 its -PRON- PRP$ cord-006252-cbelsymu 395 21 efficacy efficacy NN cord-006252-cbelsymu 395 22 in in IN cord-006252-cbelsymu 395 23 high high JJ cord-006252-cbelsymu 395 24 risk risk NN cord-006252-cbelsymu 395 25 persons person NNS cord-006252-cbelsymu 396 1 ( ( -LRB- cord-006252-cbelsymu 396 2 Recommendations Recommendations NNPS cord-006252-cbelsymu 396 3 of of IN cord-006252-cbelsymu 396 4 the the DT cord-006252-cbelsymu 396 5 Immunization Immunization NNP cord-006252-cbelsymu 396 6 Practices Practices NNPS cord-006252-cbelsymu 396 7 Advisory Advisory NNP cord-006252-cbelsymu 396 8 Committee Committee NNP cord-006252-cbelsymu 396 9 1990 1990 CD cord-006252-cbelsymu 396 10 ) ) -RRB- cord-006252-cbelsymu 396 11 . . . cord-006252-cbelsymu 397 1 Resistance resistance NN cord-006252-cbelsymu 397 2 of of IN cord-006252-cbelsymu 397 3 influenza influenza NN cord-006252-cbelsymu 397 4 A a DT cord-006252-cbelsymu 397 5 virus virus NN cord-006252-cbelsymu 397 6 to to IN cord-006252-cbelsymu 397 7 amantadine amantadine NNP cord-006252-cbelsymu 397 8 has have VBZ cord-006252-cbelsymu 397 9 been be VBN cord-006252-cbelsymu 397 10 reported report VBN cord-006252-cbelsymu 397 11 . . . cord-006252-cbelsymu 398 1 The the DT cord-006252-cbelsymu 398 2 adverse adverse JJ cord-006252-cbelsymu 398 3 effects effect NNS cord-006252-cbelsymu 398 4 of of IN cord-006252-cbelsymu 398 5 amantadine amantadine NN cord-006252-cbelsymu 398 6 at at IN cord-006252-cbelsymu 398 7 a a DT cord-006252-cbelsymu 398 8 dose dose NN cord-006252-cbelsymu 398 9 of of IN cord-006252-cbelsymu 398 10 200 200 CD cord-006252-cbelsymu 398 11 mg mg NNP cord-006252-cbelsymu 398 12 / / SYM cord-006252-cbelsymu 398 13 day day NN cord-006252-cbelsymu 398 14 involve involve VBP cord-006252-cbelsymu 398 15 the the DT cord-006252-cbelsymu 398 16 central central JJ cord-006252-cbelsymu 398 17 nervous nervous JJ cord-006252-cbelsymu 398 18 system system NN cord-006252-cbelsymu 398 19 ( ( -LRB- cord-006252-cbelsymu 398 20 nervousness nervousness NN cord-006252-cbelsymu 398 21 , , , cord-006252-cbelsymu 398 22 anxiety anxiety NN cord-006252-cbelsymu 398 23 , , , cord-006252-cbelsymu 398 24 insomnia insomnia NN cord-006252-cbelsymu 398 25 , , , cord-006252-cbelsymu 398 26 difficulty difficulty NN cord-006252-cbelsymu 398 27 concentrating concentrate VBG cord-006252-cbelsymu 398 28 and and CC cord-006252-cbelsymu 398 29 lightheadedness lightheadedness NN cord-006252-cbelsymu 398 30 ) ) -RRB- cord-006252-cbelsymu 398 31 and and CC cord-006252-cbelsymu 398 32 the the DT cord-006252-cbelsymu 398 33 gastrointestinal gastrointestinal JJ cord-006252-cbelsymu 398 34 tract tract NN cord-006252-cbelsymu 398 35 ( ( -LRB- cord-006252-cbelsymu 398 36 anorexia anorexia NN cord-006252-cbelsymu 398 37 and and CC cord-006252-cbelsymu 398 38 nausea nausea NN cord-006252-cbelsymu 398 39 ) ) -RRB- cord-006252-cbelsymu 398 40 . . . cord-006252-cbelsymu 399 1 They -PRON- PRP cord-006252-cbelsymu 399 2 usually usually RB cord-006252-cbelsymu 399 3 decrease decrease VBP cord-006252-cbelsymu 399 4 or or CC cord-006252-cbelsymu 399 5 stop stop VB cord-006252-cbelsymu 399 6 after after IN cord-006252-cbelsymu 399 7 the the DT cord-006252-cbelsymu 399 8 first first JJ cord-006252-cbelsymu 399 9 week week NN cord-006252-cbelsymu 399 10 of of IN cord-006252-cbelsymu 399 11 use use NN cord-006252-cbelsymu 399 12 or or CC cord-006252-cbelsymu 399 13 when when WRB cord-006252-cbelsymu 399 14 amantadine amantadine NNP cord-006252-cbelsymu 399 15 is be VBZ cord-006252-cbelsymu 399 16 discontinued discontinue VBN cord-006252-cbelsymu 399 17 . . . cord-006252-cbelsymu 400 1 Using use VBG cord-006252-cbelsymu 400 2 a a DT cord-006252-cbelsymu 400 3 smaller small JJR cord-006252-cbelsymu 400 4 dose dose NN cord-006252-cbelsymu 400 5 , , , cord-006252-cbelsymu 400 6 100 100 CD cord-006252-cbelsymu 400 7 mg mg NNP cord-006252-cbelsymu 400 8 / / SYM cord-006252-cbelsymu 400 9 day day NN cord-006252-cbelsymu 400 10 , , , cord-006252-cbelsymu 400 11 reduces reduce VBZ cord-006252-cbelsymu 400 12 the the DT cord-006252-cbelsymu 400 13 adverse adverse JJ cord-006252-cbelsymu 400 14 effects effect NNS cord-006252-cbelsymu 400 15 , , , cord-006252-cbelsymu 400 16 apparently apparently RB cord-006252-cbelsymu 400 17 without without IN cord-006252-cbelsymu 400 18 diminishing diminish VBG cord-006252-cbelsymu 400 19 efficacy efficacy NN cord-006252-cbelsymu 400 20 . . . cord-006252-cbelsymu 401 1 The the DT cord-006252-cbelsymu 401 2 manufacturer manufacturer NN cord-006252-cbelsymu 401 3 's 's POS cord-006252-cbelsymu 401 4 recommendations recommendation NNS cord-006252-cbelsymu 401 5 should should MD cord-006252-cbelsymu 401 6 be be VB cord-006252-cbelsymu 401 7 read read VBN cord-006252-cbelsymu 401 8 carefully carefully RB cord-006252-cbelsymu 401 9 to to TO cord-006252-cbelsymu 401 10 adjust adjust VB cord-006252-cbelsymu 401 11 the the DT cord-006252-cbelsymu 401 12 dose dose NN cord-006252-cbelsymu 401 13 for for IN cord-006252-cbelsymu 401 14 age age NN cord-006252-cbelsymu 401 15 , , , cord-006252-cbelsymu 401 16 renal renal JJ cord-006252-cbelsymu 401 17 function function NN cord-006252-cbelsymu 401 18 , , , cord-006252-cbelsymu 401 19 weight weight NN cord-006252-cbelsymu 401 20 , , , cord-006252-cbelsymu 401 21 and and CC cord-006252-cbelsymu 401 22 interactions interaction NNS cord-006252-cbelsymu 401 23 with with IN cord-006252-cbelsymu 401 24 other other JJ cord-006252-cbelsymu 401 25 drugs drug NNS cord-006252-cbelsymu 401 26 and and CC cord-006252-cbelsymu 401 27 diseases disease NNS cord-006252-cbelsymu 401 28 ( ( -LRB- cord-006252-cbelsymu 401 29 see see VB cord-006252-cbelsymu 401 30 table table NN cord-006252-cbelsymu 401 31 II II NNP cord-006252-cbelsymu 401 32 ) ) -RRB- cord-006252-cbelsymu 401 33 . . . cord-006252-cbelsymu 402 1 Rimantadine Rimantadine NNP cord-006252-cbelsymu 402 2 is be VBZ cord-006252-cbelsymu 402 3 a a DT cord-006252-cbelsymu 402 4 structural structural JJ cord-006252-cbelsymu 402 5 analogue analogue NN cord-006252-cbelsymu 402 6 of of IN cord-006252-cbelsymu 402 7 amantadine amantadine NNP cord-006252-cbelsymu 402 8 . . . cord-006252-cbelsymu 403 1 It -PRON- PRP cord-006252-cbelsymu 403 2 has have VBZ cord-006252-cbelsymu 403 3 2 2 CD cord-006252-cbelsymu 403 4 advantages advantage NNS cord-006252-cbelsymu 403 5 over over IN cord-006252-cbelsymu 403 6 amantadine amantadine NNP cord-006252-cbelsymu 403 7 : : : cord-006252-cbelsymu 403 8 it -PRON- PRP cord-006252-cbelsymu 403 9 has have VBZ cord-006252-cbelsymu 403 10 fewer few JJR cord-006252-cbelsymu 403 11 central central JJ cord-006252-cbelsymu 403 12 nervous nervous JJ cord-006252-cbelsymu 403 13 system system NN cord-006252-cbelsymu 403 14 side side NN cord-006252-cbelsymu 403 15 effects effect NNS cord-006252-cbelsymu 403 16 at at IN cord-006252-cbelsymu 403 17 doses dose NNS cord-006252-cbelsymu 403 18 of of IN cord-006252-cbelsymu 403 19 200 200 CD cord-006252-cbelsymu 403 20 mg mg NNP cord-006252-cbelsymu 403 21 / / SYM cord-006252-cbelsymu 403 22 day day NN cord-006252-cbelsymu 403 23 , , , cord-006252-cbelsymu 403 24 and and CC cord-006252-cbelsymu 403 25 , , , cord-006252-cbelsymu 403 26 because because IN cord-006252-cbelsymu 403 27 most most JJS cord-006252-cbelsymu 403 28 of of IN cord-006252-cbelsymu 403 29 the the DT cord-006252-cbelsymu 403 30 drug drug NN cord-006252-cbelsymu 403 31 is be VBZ cord-006252-cbelsymu 403 32 Drugs drug NNS cord-006252-cbelsymu 403 33 & & CC cord-006252-cbelsymu 403 34 Aging age VBG cord-006252-cbelsymu 403 35 1 1 CD cord-006252-cbelsymu 403 36 ( ( -LRB- cord-006252-cbelsymu 403 37 6 6 CD cord-006252-cbelsymu 403 38 ) ) -RRB- cord-006252-cbelsymu 403 39 1991 1991 CD cord-006252-cbelsymu 403 40 metabolised metabolise VBN cord-006252-cbelsymu 403 41 , , , cord-006252-cbelsymu 403 42 elimination elimination NN cord-006252-cbelsymu 403 43 from from IN cord-006252-cbelsymu 403 44 the the DT cord-006252-cbelsymu 403 45 body body NN cord-006252-cbelsymu 403 46 is be VBZ cord-006252-cbelsymu 403 47 not not RB cord-006252-cbelsymu 403 48 dependent dependent JJ cord-006252-cbelsymu 403 49 on on IN cord-006252-cbelsymu 403 50 renal renal JJ cord-006252-cbelsymu 403 51 excretion excretion NN cord-006252-cbelsymu 403 52 . . . cord-006252-cbelsymu 404 1 The the DT cord-006252-cbelsymu 404 2 use use NN cord-006252-cbelsymu 404 3 of of IN cord-006252-cbelsymu 404 4 influenza influenza NN cord-006252-cbelsymu 404 5 vaccine vaccine NN cord-006252-cbelsymu 404 6 in in IN cord-006252-cbelsymu 404 7 the the DT cord-006252-cbelsymu 404 8 elderly elderly JJ cord-006252-cbelsymu 404 9 is be VBZ cord-006252-cbelsymu 404 10 no no RB cord-006252-cbelsymu 404 11 longer long RBR cord-006252-cbelsymu 404 12 an an DT cord-006252-cbelsymu 404 13 oPtion"to oPtion"to NNS cord-006252-cbelsymu 404 14 be be VB cord-006252-cbelsymu 404 15 exercised exercise VBN cord-006252-cbelsymu 404 16 only only RB cord-006252-cbelsymu 404 17 occasionally occasionally RB cord-006252-cbelsymu 404 18 . . . cord-006252-cbelsymu 405 1 Administration administration NN cord-006252-cbelsymu 405 2 of of IN cord-006252-cbelsymu 405 3 influenza influenza NNP cord-006252-cbelsymu 405 4 vaccine vaccine NN cord-006252-cbelsymu 405 5 and and CC cord-006252-cbelsymu 405 6 the the DT cord-006252-cbelsymu 405 7 use use NN cord-006252-cbelsymu 405 8 of of IN cord-006252-cbelsymu 405 9 amantadine amantadine NNP cord-006252-cbelsymu 405 10 when when WRB cord-006252-cbelsymu 405 11 indicated indicate VBN cord-006252-cbelsymu 405 12 should should MD cord-006252-cbelsymu 405 13 become become VB cord-006252-cbelsymu 405 14 a a DT cord-006252-cbelsymu 405 15 standard standard JJ cord-006252-cbelsymu 405 16 part part NN cord-006252-cbelsymu 405 17 of of IN cord-006252-cbelsymu 405 18 the the DT cord-006252-cbelsymu 405 19 care care NN cord-006252-cbelsymu 405 20 given give VBN cord-006252-cbelsymu 405 21 our -PRON- PRP$ cord-006252-cbelsymu 405 22 elderly elderly JJ cord-006252-cbelsymu 405 23 population population NN cord-006252-cbelsymu 405 24 ( ( -LRB- cord-006252-cbelsymu 405 25 Nicholson Nicholson NNP cord-006252-cbelsymu 405 26 1990 1990 CD cord-006252-cbelsymu 405 27 ) ) -RRB- cord-006252-cbelsymu 405 28 . . . cord-006252-cbelsymu 406 1 a a DT cord-006252-cbelsymu 406 2 therapeutic therapeutic JJ cord-006252-cbelsymu 406 3 effect effect NN cord-006252-cbelsymu 406 4 . . . cord-006252-cbelsymu 407 1 The the DT cord-006252-cbelsymu 407 2 duration duration NN cord-006252-cbelsymu 407 3 of of IN cord-006252-cbelsymu 407 4 illness illness NN cord-006252-cbelsymu 407 5 decreases decrease VBZ cord-006252-cbelsymu 407 6 by by IN cord-006252-cbelsymu 407 7 50 50 CD cord-006252-cbelsymu 407 8 % % NN cord-006252-cbelsymu 407 9 , , , cord-006252-cbelsymu 407 10 virus virus NN cord-006252-cbelsymu 407 11 shedding shed VBG cord-006252-cbelsymu 407 12 decreases decrease VBZ cord-006252-cbelsymu 407 13 more more RBR cord-006252-cbelsymu 407 14 rapidly rapidly RB cord-006252-cbelsymu 407 15 , , , cord-006252-cbelsymu 407 16 and and CC cord-006252-cbelsymu 407 17 peripheral peripheral JJ cord-006252-cbelsymu 407 18 airway airway NN cord-006252-cbelsymu 407 19 resistance resistance NN cord-006252-cbelsymu 407 20 is be VBZ cord-006252-cbelsymu 407 21 reduced reduce VBN cord-006252-cbelsymu 407 22 faster fast RBR cord-006252-cbelsymu 407 23 . . . cord-006252-cbelsymu 408 1 Serum serum NN cord-006252-cbelsymu 408 2 antibody antibody NN cord-006252-cbelsymu 408 3 still still RB cord-006252-cbelsymu 408 4 develops develop VBZ cord-006252-cbelsymu 408 5 despite despite IN cord-006252-cbelsymu 408 6 the the DT cord-006252-cbelsymu 408 7 use use NN cord-006252-cbelsymu 408 8 of of IN cord-006252-cbelsymu 408 9 amantadine amantadine NNP cord-006252-cbelsymu 408 10 . . . cord-006252-cbelsymu 409 1 Amantadine Amantadine NNP cord-006252-cbelsymu 409 2 treatment treatment NN cord-006252-cbelsymu 409 3 for for IN cord-006252-cbelsymu 409 4 the the DT cord-006252-cbelsymu 409 5 acute acute JJ cord-006252-cbelsymu 409 6 illness illness NN cord-006252-cbelsymu 409 7 should should MD cord-006252-cbelsymu 409 8 be be VB cord-006252-cbelsymu 409 9 continued continue VBN cord-006252-cbelsymu 409 10 for for IN cord-006252-cbelsymu 409 11 5 5 CD cord-006252-cbelsymu 409 12 days day NNS cord-006252-cbelsymu 409 13 . . . cord-006252-cbelsymu 410 1 Studies study NNS cord-006252-cbelsymu 410 2 on on IN cord-006252-cbelsymu 410 3 the the DT cord-006252-cbelsymu 410 4 therapeutic therapeutic JJ cord-006252-cbelsymu 410 5 efficacy efficacy NN cord-006252-cbelsymu 410 6 of of IN cord-006252-cbelsymu 410 7 amantadine amantadine NNP cord-006252-cbelsymu 410 8 have have VBP cord-006252-cbelsymu 410 9 been be VBN cord-006252-cbelsymu 410 10 done do VBN cord-006252-cbelsymu 410 11 in in IN cord-006252-cbelsymu 410 12 healthy healthy JJ cord-006252-cbelsymu 410 13 adults adult NNS cord-006252-cbelsymu 410 14 ; ; : cord-006252-cbelsymu 410 15 there there EX cord-006252-cbelsymu 410 16 are be VBP cord-006252-cbelsymu 410 17 no no DT cord-006252-cbelsymu 410 18 data data NN cord-006252-cbelsymu 410 19 on on IN cord-006252-cbelsymu 410 20 its -PRON- PRP$ cord-006252-cbelsymu 410 21 efficacy efficacy NN cord-006252-cbelsymu 410 22 in in IN cord-006252-cbelsymu 410 23 high high JJ cord-006252-cbelsymu 410 24 risk risk NN cord-006252-cbelsymu 410 25 persons person NNS cord-006252-cbelsymu 411 1 ( ( -LRB- cord-006252-cbelsymu 411 2 Recommendations Recommendations NNPS cord-006252-cbelsymu 411 3 of of IN cord-006252-cbelsymu 411 4 the the DT cord-006252-cbelsymu 411 5 Immunization Immunization NNP cord-006252-cbelsymu 411 6 Practices Practices NNPS cord-006252-cbelsymu 411 7 Advisory Advisory NNP cord-006252-cbelsymu 411 8 Committee Committee NNP cord-006252-cbelsymu 411 9 1990 1990 CD cord-006252-cbelsymu 411 10 ) ) -RRB- cord-006252-cbelsymu 411 11 . . . cord-006252-cbelsymu 412 1 Resistance resistance NN cord-006252-cbelsymu 412 2 of of IN cord-006252-cbelsymu 412 3 influenza influenza NN cord-006252-cbelsymu 412 4 A a DT cord-006252-cbelsymu 412 5 virus virus NN cord-006252-cbelsymu 412 6 to to IN cord-006252-cbelsymu 412 7 amantadine amantadine NNP cord-006252-cbelsymu 412 8 has have VBZ cord-006252-cbelsymu 412 9 been be VBN cord-006252-cbelsymu 412 10 reported report VBN cord-006252-cbelsymu 412 11 . . . cord-006252-cbelsymu 413 1 The the DT cord-006252-cbelsymu 413 2 adverse adverse JJ cord-006252-cbelsymu 413 3 effects effect NNS cord-006252-cbelsymu 413 4 of of IN cord-006252-cbelsymu 413 5 amantadine amantadine NN cord-006252-cbelsymu 413 6 at at IN cord-006252-cbelsymu 413 7 a a DT cord-006252-cbelsymu 413 8 dose dose NN cord-006252-cbelsymu 413 9 of of IN cord-006252-cbelsymu 413 10 200 200 CD cord-006252-cbelsymu 413 11 mg mg NNP cord-006252-cbelsymu 413 12 / / SYM cord-006252-cbelsymu 413 13 day day NN cord-006252-cbelsymu 413 14 involve involve VBP cord-006252-cbelsymu 413 15 the the DT cord-006252-cbelsymu 413 16 central central JJ cord-006252-cbelsymu 413 17 nervous nervous JJ cord-006252-cbelsymu 413 18 system system NN cord-006252-cbelsymu 413 19 ( ( -LRB- cord-006252-cbelsymu 413 20 nervousness nervousness NN cord-006252-cbelsymu 413 21 , , , cord-006252-cbelsymu 413 22 anxiety anxiety NN cord-006252-cbelsymu 413 23 , , , cord-006252-cbelsymu 413 24 insomnia insomnia NN cord-006252-cbelsymu 413 25 , , , cord-006252-cbelsymu 413 26 difficulty difficulty NN cord-006252-cbelsymu 413 27 concentrating concentrate VBG cord-006252-cbelsymu 413 28 and and CC cord-006252-cbelsymu 413 29 lightheadedness lightheadedness NN cord-006252-cbelsymu 413 30 ) ) -RRB- cord-006252-cbelsymu 413 31 and and CC cord-006252-cbelsymu 413 32 the the DT cord-006252-cbelsymu 413 33 gastrointestinal gastrointestinal JJ cord-006252-cbelsymu 413 34 tract tract NN cord-006252-cbelsymu 413 35 ( ( -LRB- cord-006252-cbelsymu 413 36 anorexia anorexia NN cord-006252-cbelsymu 413 37 and and CC cord-006252-cbelsymu 413 38 nausea nausea NN cord-006252-cbelsymu 413 39 ) ) -RRB- cord-006252-cbelsymu 413 40 . . . cord-006252-cbelsymu 414 1 They -PRON- PRP cord-006252-cbelsymu 414 2 usually usually RB cord-006252-cbelsymu 414 3 decrease decrease VBP cord-006252-cbelsymu 414 4 or or CC cord-006252-cbelsymu 414 5 stop stop VB cord-006252-cbelsymu 414 6 after after IN cord-006252-cbelsymu 414 7 the the DT cord-006252-cbelsymu 414 8 first first JJ cord-006252-cbelsymu 414 9 week week NN cord-006252-cbelsymu 414 10 of of IN cord-006252-cbelsymu 414 11 use use NN cord-006252-cbelsymu 414 12 or or CC cord-006252-cbelsymu 414 13 when when WRB cord-006252-cbelsymu 414 14 amantadine amantadine NNP cord-006252-cbelsymu 414 15 is be VBZ cord-006252-cbelsymu 414 16 discontinued discontinue VBN cord-006252-cbelsymu 414 17 . . . cord-006252-cbelsymu 415 1 Using use VBG cord-006252-cbelsymu 415 2 a a DT cord-006252-cbelsymu 415 3 smaller small JJR cord-006252-cbelsymu 415 4 dose dose NN cord-006252-cbelsymu 415 5 , , , cord-006252-cbelsymu 415 6 100 100 CD cord-006252-cbelsymu 415 7 mg mg NNP cord-006252-cbelsymu 415 8 / / SYM cord-006252-cbelsymu 415 9 day day NN cord-006252-cbelsymu 415 10 , , , cord-006252-cbelsymu 415 11 reduces reduce VBZ cord-006252-cbelsymu 415 12 the the DT cord-006252-cbelsymu 415 13 adverse adverse JJ cord-006252-cbelsymu 415 14 effects effect NNS cord-006252-cbelsymu 415 15 , , , cord-006252-cbelsymu 415 16 apparently apparently RB cord-006252-cbelsymu 415 17 without without IN cord-006252-cbelsymu 415 18 diminishing diminish VBG cord-006252-cbelsymu 415 19 efficacy efficacy NN cord-006252-cbelsymu 415 20 . . . cord-006252-cbelsymu 416 1 The the DT cord-006252-cbelsymu 416 2 manufacturer manufacturer NN cord-006252-cbelsymu 416 3 's 's POS cord-006252-cbelsymu 416 4 recommendations recommendation NNS cord-006252-cbelsymu 416 5 should should MD cord-006252-cbelsymu 416 6 be be VB cord-006252-cbelsymu 416 7 read read VBN cord-006252-cbelsymu 416 8 carefully carefully RB cord-006252-cbelsymu 416 9 to to TO cord-006252-cbelsymu 416 10 adjust adjust VB cord-006252-cbelsymu 416 11 the the DT cord-006252-cbelsymu 416 12 dose dose NN cord-006252-cbelsymu 416 13 for for IN cord-006252-cbelsymu 416 14 age age NN cord-006252-cbelsymu 416 15 , , , cord-006252-cbelsymu 416 16 renal renal JJ cord-006252-cbelsymu 416 17 function function NN cord-006252-cbelsymu 416 18 , , , cord-006252-cbelsymu 416 19 weight weight NN cord-006252-cbelsymu 416 20 , , , cord-006252-cbelsymu 416 21 and and CC cord-006252-cbelsymu 416 22 interactions interaction NNS cord-006252-cbelsymu 416 23 with with IN cord-006252-cbelsymu 416 24 other other JJ cord-006252-cbelsymu 416 25 drugs drug NNS cord-006252-cbelsymu 416 26 and and CC cord-006252-cbelsymu 416 27 diseases disease NNS cord-006252-cbelsymu 416 28 ( ( -LRB- cord-006252-cbelsymu 416 29 see see VB cord-006252-cbelsymu 416 30 table table NN cord-006252-cbelsymu 416 31 II II NNP cord-006252-cbelsymu 416 32 ) ) -RRB- cord-006252-cbelsymu 416 33 . . . cord-006252-cbelsymu 417 1 Rimantadine Rimantadine NNP cord-006252-cbelsymu 417 2 is be VBZ cord-006252-cbelsymu 417 3 a a DT cord-006252-cbelsymu 417 4 structural structural JJ cord-006252-cbelsymu 417 5 analogue analogue NN cord-006252-cbelsymu 417 6 of of IN cord-006252-cbelsymu 417 7 amantadine amantadine NNP cord-006252-cbelsymu 417 8 . . . cord-006252-cbelsymu 418 1 It -PRON- PRP cord-006252-cbelsymu 418 2 has have VBZ cord-006252-cbelsymu 418 3 2 2 CD cord-006252-cbelsymu 418 4 advantages advantage NNS cord-006252-cbelsymu 418 5 over over IN cord-006252-cbelsymu 418 6 amantadine amantadine NNP cord-006252-cbelsymu 418 7 : : : cord-006252-cbelsymu 418 8 it -PRON- PRP cord-006252-cbelsymu 418 9 has have VBZ cord-006252-cbelsymu 418 10 fewer few JJR cord-006252-cbelsymu 418 11 central central JJ cord-006252-cbelsymu 418 12 nervous nervous JJ cord-006252-cbelsymu 418 13 system system NN cord-006252-cbelsymu 418 14 side side NN cord-006252-cbelsymu 418 15 effects effect NNS cord-006252-cbelsymu 418 16 at at IN cord-006252-cbelsymu 418 17 doses dose NNS cord-006252-cbelsymu 418 18 of of IN cord-006252-cbelsymu 418 19 200 200 CD cord-006252-cbelsymu 418 20 mg mg NNP cord-006252-cbelsymu 418 21 / / SYM cord-006252-cbelsymu 418 22 day day NN cord-006252-cbelsymu 418 23 , , , cord-006252-cbelsymu 418 24 and and CC cord-006252-cbelsymu 418 25 , , , cord-006252-cbelsymu 418 26 because because IN cord-006252-cbelsymu 418 27 most most JJS cord-006252-cbelsymu 418 28 of of IN cord-006252-cbelsymu 418 29 the the DT cord-006252-cbelsymu 418 30 drug drug NN cord-006252-cbelsymu 418 31 is be VBZ cord-006252-cbelsymu 418 32 Drugs drug NNS cord-006252-cbelsymu 418 33 & & CC cord-006252-cbelsymu 418 34 Aging age VBG cord-006252-cbelsymu 418 35 1 1 CD cord-006252-cbelsymu 418 36 ( ( -LRB- cord-006252-cbelsymu 418 37 6 6 CD cord-006252-cbelsymu 418 38 ) ) -RRB- cord-006252-cbelsymu 418 39 1991 1991 CD cord-006252-cbelsymu 418 40 metabolised metabolise VBN cord-006252-cbelsymu 418 41 , , , cord-006252-cbelsymu 418 42 elimination elimination NN cord-006252-cbelsymu 418 43 from from IN cord-006252-cbelsymu 418 44 the the DT cord-006252-cbelsymu 418 45 body body NN cord-006252-cbelsymu 418 46 is be VBZ cord-006252-cbelsymu 418 47 not not RB cord-006252-cbelsymu 418 48 dependent dependent JJ cord-006252-cbelsymu 418 49 on on IN cord-006252-cbelsymu 418 50 renal renal JJ cord-006252-cbelsymu 418 51 excretion excretion NN cord-006252-cbelsymu 418 52 . . . cord-006252-cbelsymu 419 1 The the DT cord-006252-cbelsymu 419 2 use use NN cord-006252-cbelsymu 419 3 of of IN cord-006252-cbelsymu 419 4 influenza influenza NN cord-006252-cbelsymu 419 5 vaccine vaccine NN cord-006252-cbelsymu 419 6 in in IN cord-006252-cbelsymu 419 7 the the DT cord-006252-cbelsymu 419 8 elderly elderly JJ cord-006252-cbelsymu 419 9 is be VBZ cord-006252-cbelsymu 419 10 no no RB cord-006252-cbelsymu 419 11 longer long RBR cord-006252-cbelsymu 419 12 an an DT cord-006252-cbelsymu 419 13 option option NN cord-006252-cbelsymu 419 14 to to TO cord-006252-cbelsymu 419 15 be be VB cord-006252-cbelsymu 419 16 exercised exercise VBN cord-006252-cbelsymu 419 17 only only RB cord-006252-cbelsymu 419 18 occasionally occasionally RB cord-006252-cbelsymu 419 19 . . . cord-006252-cbelsymu 420 1 Administration administration NN cord-006252-cbelsymu 421 1 ~f ~f NNP cord-006252-cbelsymu 421 2 influenza influenza NN cord-006252-cbelsymu 421 3 vaccine vaccine NN cord-006252-cbelsymu 421 4 and and CC cord-006252-cbelsymu 421 5 the the DT cord-006252-cbelsymu 421 6 use use NN cord-006252-cbelsymu 421 7 of of IN cord-006252-cbelsymu 421 8 amantadine amantadine NNP cord-006252-cbelsymu 421 9 when when WRB cord-006252-cbelsymu 421 10 indicated indicate VBN cord-006252-cbelsymu 421 11 should should MD cord-006252-cbelsymu 421 12 become become VB cord-006252-cbelsymu 421 13 a a DT cord-006252-cbelsymu 421 14 standard standard JJ cord-006252-cbelsymu 421 15 part part NN cord-006252-cbelsymu 421 16 of of IN cord-006252-cbelsymu 421 17 the the DT cord-006252-cbelsymu 421 18 care care NN cord-006252-cbelsymu 421 19 given give VBN cord-006252-cbelsymu 421 20 our -PRON- PRP$ cord-006252-cbelsymu 421 21 elderly elderly JJ cord-006252-cbelsymu 421 22 population population NN cord-006252-cbelsymu 421 23 ( ( -LRB- cord-006252-cbelsymu 421 24 Nicholson Nicholson NNP cord-006252-cbelsymu 421 25 1990 1990 CD cord-006252-cbelsymu 421 26 ) ) -RRB- cord-006252-cbelsymu 421 27 . . . cord-006252-cbelsymu 422 1 Experiences experience NNS cord-006252-cbelsymu 422 2 in in IN cord-006252-cbelsymu 422 3 the the DT cord-006252-cbelsymu 422 4 use use NN cord-006252-cbelsymu 422 5 and and CC cord-006252-cbelsymu 422 6 efficacy efficacy NN cord-006252-cbelsymu 422 7 of of IN cord-006252-cbelsymu 422 8 inactivated inactivate VBN cord-006252-cbelsymu 422 9 influenza influenza NN cord-006252-cbelsymu 422 10 vaccine vaccine NN cord-006252-cbelsymu 422 11 in in IN cord-006252-cbelsymu 422 12 nursing nurse VBG cord-006252-cbelsymu 422 13 homes home NNS cord-006252-cbelsymu 422 14 Impact Impact NNP cord-006252-cbelsymu 422 15 of of IN cord-006252-cbelsymu 422 16 epidemic epidemic NN cord-006252-cbelsymu 422 17 type type NN cord-006252-cbelsymu 423 1 A a DT cord-006252-cbelsymu 423 2 influenza influenza NN cord-006252-cbelsymu 423 3 in in IN cord-006252-cbelsymu 423 4 a a DT cord-006252-cbelsymu 423 5 defined define VBN cord-006252-cbelsymu 423 6 adult adult NN cord-006252-cbelsymu 423 7 population population NN cord-006252-cbelsymu 423 8 Underestimation underestimation NN cord-006252-cbelsymu 423 9 of of IN cord-006252-cbelsymu 423 10 the the DT cord-006252-cbelsymu 423 11 role role NN cord-006252-cbelsymu 423 12 of of IN cord-006252-cbelsymu 423 13 pneumonia pneumonia NN cord-006252-cbelsymu 423 14 and and CC cord-006252-cbelsymu 423 15 influenza influenza NN cord-006252-cbelsymu 423 16 in in IN cord-006252-cbelsymu 423 17 causing cause VBG cord-006252-cbelsymu 423 18 excess excess JJ cord-006252-cbelsymu 423 19 mortality mortality NN cord-006252-cbelsymu 423 20 Effectiveness Effectiveness NNP cord-006252-cbelsymu 423 21 of of IN cord-006252-cbelsymu 423 22 inactivated inactivate VBN cord-006252-cbelsymu 423 23 influenza influenza NN cord-006252-cbelsymu 423 24 vaccine vaccine NN cord-006252-cbelsymu 423 25 among among IN cord-006252-cbelsymu 423 26 non non JJ cord-006252-cbelsymu 423 27 - - JJ cord-006252-cbelsymu 423 28 institutionalized institutionalized JJ cord-006252-cbelsymu 423 29 elderly elderly JJ cord-006252-cbelsymu 423 30 persons person NNS cord-006252-cbelsymu 423 31 Resistance Resistance NNP cord-006252-cbelsymu 423 32 of of IN cord-006252-cbelsymu 423 33 influenza influenza NN cord-006252-cbelsymu 423 34 A a DT cord-006252-cbelsymu 423 35 virus virus NN cord-006252-cbelsymu 423 36 to to IN cord-006252-cbelsymu 423 37 amantadine amantadine NNP cord-006252-cbelsymu 423 38 and and CC cord-006252-cbelsymu 423 39 rimantadine rimantadine NN cord-006252-cbelsymu 423 40 : : : cord-006252-cbelsymu 423 41 results result NNS cord-006252-cbelsymu 423 42 of of IN cord-006252-cbelsymu 423 43 one one CD cord-006252-cbelsymu 423 44 decade decade NN cord-006252-cbelsymu 423 45 of of IN cord-006252-cbelsymu 423 46 surveillance surveillance NN cord-006252-cbelsymu 423 47 Antibody antibody NN cord-006252-cbelsymu 423 48 induced induce VBN cord-006252-cbelsymu 423 49 by by IN cord-006252-cbelsymu 423 50 influenza influenza NN cord-006252-cbelsymu 423 51 vaccines vaccine NNS cord-006252-cbelsymu 423 52 in in IN cord-006252-cbelsymu 423 53 the the DT cord-006252-cbelsymu 423 54 elderly elderly JJ cord-006252-cbelsymu 423 55 : : : cord-006252-cbelsymu 423 56 a a DT cord-006252-cbelsymu 423 57 review review NN cord-006252-cbelsymu 423 58 of of IN cord-006252-cbelsymu 423 59 the the DT cord-006252-cbelsymu 423 60 literature literature NN cord-006252-cbelsymu 423 61 Influenza Influenza NNP cord-006252-cbelsymu 423 62 vaccination vaccination NN cord-006252-cbelsymu 423 63 in in IN cord-006252-cbelsymu 423 64 community community NN cord-006252-cbelsymu 423 65 elderly elderly JJ cord-006252-cbelsymu 423 66 : : : cord-006252-cbelsymu 423 67 a a DT cord-006252-cbelsymu 423 68 controlled control VBN cord-006252-cbelsymu 423 69 trial trial NN cord-006252-cbelsymu 423 70 of of IN cord-006252-cbelsymu 423 71 postcard postcard NN cord-006252-cbelsymu 423 72 reminders reminder NNS cord-006252-cbelsymu 423 73 Clinical clinical JJ cord-006252-cbelsymu 423 74 manifestations manifestation NNS cord-006252-cbelsymu 423 75 and and CC cord-006252-cbelsymu 423 76 consequences consequence NNS cord-006252-cbelsymu 423 77 of of IN cord-006252-cbelsymu 423 78 influenza influenza NN cord-006252-cbelsymu 423 79 Antimicrobial Antimicrobial NNP cord-006252-cbelsymu 423 80 agents agent NNS cord-006252-cbelsymu 423 81 : : : cord-006252-cbelsymu 423 82 antiviral antiviral JJ cord-006252-cbelsymu 423 83 agents agent NNS cord-006252-cbelsymu 423 84 Immunizations immunization NNS cord-006252-cbelsymu 423 85 for for IN cord-006252-cbelsymu 423 86 health health NN cord-006252-cbelsymu 423 87 care care NN cord-006252-cbelsymu 423 88 workers worker NNS cord-006252-cbelsymu 423 89 and and CC cord-006252-cbelsymu 423 90 patients patient NNS cord-006252-cbelsymu 423 91 in in IN cord-006252-cbelsymu 423 92 hospitals hospital NNS cord-006252-cbelsymu 423 93 Survey Survey NNP cord-006252-cbelsymu 423 94 of of IN cord-006252-cbelsymu 423 95 underlying underlying JJ cord-006252-cbelsymu 423 96 conditions condition NNS cord-006252-cbelsymu 423 97 of of IN cord-006252-cbelsymu 423 98 persons person NNS cord-006252-cbelsymu 423 99 hospitalized hospitalize VBN cord-006252-cbelsymu 423 100 with with IN cord-006252-cbelsymu 423 101 acute acute JJ cord-006252-cbelsymu 423 102 respiratory respiratory JJ cord-006252-cbelsymu 423 103 disease disease NN cord-006252-cbelsymu 423 104 during during IN cord-006252-cbelsymu 423 105 influenza influenza NN cord-006252-cbelsymu 423 106 epidemics epidemic NNS cord-006252-cbelsymu 423 107 in in IN cord-006252-cbelsymu 423 108 Houston Houston NNP cord-006252-cbelsymu 423 109 Lack Lack NNP cord-006252-cbelsymu 423 110 of of IN cord-006252-cbelsymu 423 111 effect effect NN cord-006252-cbelsymu 423 112 of of IN cord-006252-cbelsymu 423 113 influenza influenza JJ cord-006252-cbelsymu 423 114 vaccine vaccine NN cord-006252-cbelsymu 423 115 on on IN cord-006252-cbelsymu 423 116 theophylline theophylline JJ cord-006252-cbelsymu 423 117 levels level NNS cord-006252-cbelsymu 423 118 and and CC cord-006252-cbelsymu 423 119 warfarin warfarin NN cord-006252-cbelsymu 423 120 anticoagulation anticoagulation NN cord-006252-cbelsymu 423 121 in in IN cord-006252-cbelsymu 423 122 the the DT cord-006252-cbelsymu 423 123 elderly elderly JJ cord-006252-cbelsymu 424 1 The the DT cord-006252-cbelsymu 424 2 effect effect NN cord-006252-cbelsymu 424 3 of of IN cord-006252-cbelsymu 424 4 split split NN cord-006252-cbelsymu 424 5 virus virus NN cord-006252-cbelsymu 424 6 influenza influenza NN cord-006252-cbelsymu 424 7 vaccination vaccination NN cord-006252-cbelsymu 424 8 on on IN cord-006252-cbelsymu 424 9 theophylline theophylline JJ cord-006252-cbelsymu 424 10 pharmacokinetics pharmacokinetics NNP cord-006252-cbelsymu 424 11 Association Association NNP cord-006252-cbelsymu 424 12 of of IN cord-006252-cbelsymu 424 13 in in IN cord-006252-cbelsymu 424 14 fluenza fluenza NNP cord-006252-cbelsymu 424 15 immunization immunization NN cord-006252-cbelsymu 424 16 with with IN cord-006252-cbelsymu 424 17 reduction reduction NN cord-006252-cbelsymu 424 18 in in IN cord-006252-cbelsymu 424 19 mortality mortality NN cord-006252-cbelsymu 424 20 in in IN cord-006252-cbelsymu 424 21 an an DT cord-006252-cbelsymu 424 22 elderly elderly JJ cord-006252-cbelsymu 424 23 References reference NNS cord-006252-cbelsymu 424 24 Experiences experience NNS cord-006252-cbelsymu 424 25 in in IN cord-006252-cbelsymu 424 26 the the DT cord-006252-cbelsymu 424 27 use use NN cord-006252-cbelsymu 424 28 and and CC cord-006252-cbelsymu 424 29 efficacy efficacy NN cord-006252-cbelsymu 424 30 of of IN cord-006252-cbelsymu 424 31 inactivated inactivate VBN cord-006252-cbelsymu 424 32 influenza influenza NN cord-006252-cbelsymu 424 33 vaccine vaccine NN cord-006252-cbelsymu 424 34 in in IN cord-006252-cbelsymu 424 35 nursing nurse VBG cord-006252-cbelsymu 424 36 homes home NNS cord-006252-cbelsymu 424 37 Impact Impact NNP cord-006252-cbelsymu 424 38 of of IN cord-006252-cbelsymu 424 39 epidemic epidemic NN cord-006252-cbelsymu 424 40 type type NN cord-006252-cbelsymu 425 1 A a DT cord-006252-cbelsymu 425 2 influenza influenza NN cord-006252-cbelsymu 425 3 in in IN cord-006252-cbelsymu 425 4 a a DT cord-006252-cbelsymu 425 5 defined define VBN cord-006252-cbelsymu 425 6 adult adult NN cord-006252-cbelsymu 425 7 population population NN cord-006252-cbelsymu 425 8 Underestimation underestimation NN cord-006252-cbelsymu 425 9 of of IN cord-006252-cbelsymu 425 10 the the DT cord-006252-cbelsymu 425 11 role role NN cord-006252-cbelsymu 425 12 of of IN cord-006252-cbelsymu 425 13 pneumonia pneumonia NN cord-006252-cbelsymu 425 14 and and CC cord-006252-cbelsymu 425 15 influenza influenza NN cord-006252-cbelsymu 425 16 in in IN cord-006252-cbelsymu 425 17 causing cause VBG cord-006252-cbelsymu 425 18 excess excess JJ cord-006252-cbelsymu 425 19 mortality mortality NN cord-006252-cbelsymu 425 20 Effectiveness Effectiveness NNP cord-006252-cbelsymu 425 21 of of IN cord-006252-cbelsymu 425 22 inactivated inactivate VBN cord-006252-cbelsymu 425 23 influenza influenza NN cord-006252-cbelsymu 425 24 vaccine vaccine NN cord-006252-cbelsymu 425 25 among among IN cord-006252-cbelsymu 425 26 non non JJ cord-006252-cbelsymu 425 27 - - JJ cord-006252-cbelsymu 425 28 institutionalized institutionalized JJ cord-006252-cbelsymu 425 29 elderly elderly JJ cord-006252-cbelsymu 425 30 persons person NNS cord-006252-cbelsymu 425 31 Resistance Resistance NNP cord-006252-cbelsymu 425 32 of of IN cord-006252-cbelsymu 425 33 influenza influenza NN cord-006252-cbelsymu 425 34 A a DT cord-006252-cbelsymu 425 35 virus virus NN cord-006252-cbelsymu 425 36 to to IN cord-006252-cbelsymu 425 37 amantadine amantadine NNP cord-006252-cbelsymu 425 38 and and CC cord-006252-cbelsymu 425 39 rimantadine rimantadine NN cord-006252-cbelsymu 425 40 : : : cord-006252-cbelsymu 425 41 results result NNS cord-006252-cbelsymu 425 42 of of IN cord-006252-cbelsymu 425 43 one one CD cord-006252-cbelsymu 425 44 decade decade NN cord-006252-cbelsymu 425 45 of of IN cord-006252-cbelsymu 425 46 surveillance surveillance NN cord-006252-cbelsymu 425 47 Antibody antibody NN cord-006252-cbelsymu 425 48 induced induce VBN cord-006252-cbelsymu 425 49 by by IN cord-006252-cbelsymu 425 50 influenza influenza NN cord-006252-cbelsymu 425 51 vaccines vaccine NNS cord-006252-cbelsymu 425 52 in in IN cord-006252-cbelsymu 425 53 the the DT cord-006252-cbelsymu 425 54 elderly elderly JJ cord-006252-cbelsymu 425 55 : : : cord-006252-cbelsymu 425 56 a a DT cord-006252-cbelsymu 425 57 review review NN cord-006252-cbelsymu 425 58 of of IN cord-006252-cbelsymu 425 59 the the DT cord-006252-cbelsymu 425 60 literature literature NN cord-006252-cbelsymu 425 61 Influenza Influenza NNP cord-006252-cbelsymu 425 62 vaccination vaccination NN cord-006252-cbelsymu 425 63 in in IN cord-006252-cbelsymu 425 64 community community NN cord-006252-cbelsymu 425 65 elderly elderly JJ cord-006252-cbelsymu 425 66 : : : cord-006252-cbelsymu 425 67 a a DT cord-006252-cbelsymu 425 68 controlled control VBN cord-006252-cbelsymu 425 69 trial trial NN cord-006252-cbelsymu 425 70 of of IN cord-006252-cbelsymu 425 71 postcard postcard NN cord-006252-cbelsymu 425 72 reminders reminder NNS cord-006252-cbelsymu 425 73 Clinical clinical JJ cord-006252-cbelsymu 425 74 manifestations manifestation NNS cord-006252-cbelsymu 425 75 and and CC cord-006252-cbelsymu 425 76 consequences consequence NNS cord-006252-cbelsymu 425 77 of of IN cord-006252-cbelsymu 425 78 influenza influenza NN cord-006252-cbelsymu 425 79 Antimicrobial Antimicrobial NNP cord-006252-cbelsymu 425 80 agents agent NNS cord-006252-cbelsymu 425 81 : : : cord-006252-cbelsymu 425 82 antiviral antiviral JJ cord-006252-cbelsymu 425 83 agents agent NNS cord-006252-cbelsymu 425 84 Immunizations immunization NNS cord-006252-cbelsymu 425 85 for for IN cord-006252-cbelsymu 425 86 health health NN cord-006252-cbelsymu 425 87 care care NN cord-006252-cbelsymu 425 88 workers worker NNS cord-006252-cbelsymu 425 89 and and CC cord-006252-cbelsymu 425 90 patients patient NNS cord-006252-cbelsymu 425 91 in in IN cord-006252-cbelsymu 425 92 hospitals hospital NNS cord-006252-cbelsymu 425 93 Survey Survey NNP cord-006252-cbelsymu 425 94 of of IN cord-006252-cbelsymu 425 95 underlying underlying JJ cord-006252-cbelsymu 425 96 conditions condition NNS cord-006252-cbelsymu 425 97 of of IN cord-006252-cbelsymu 425 98 persons person NNS cord-006252-cbelsymu 425 99 hospitalized hospitalize VBN cord-006252-cbelsymu 425 100 with with IN cord-006252-cbelsymu 425 101 acute acute JJ cord-006252-cbelsymu 425 102 respiratory respiratory JJ cord-006252-cbelsymu 425 103 disease disease NN cord-006252-cbelsymu 425 104 during during IN cord-006252-cbelsymu 425 105 influenza influenza NN cord-006252-cbelsymu 425 106 epidemics epidemic NNS cord-006252-cbelsymu 425 107 in in IN cord-006252-cbelsymu 425 108 Houston Houston NNP cord-006252-cbelsymu 425 109 Lack Lack NNP cord-006252-cbelsymu 425 110 of of IN cord-006252-cbelsymu 425 111 effect effect NN cord-006252-cbelsymu 425 112 of of IN cord-006252-cbelsymu 425 113 influenza influenza JJ cord-006252-cbelsymu 425 114 vaccine vaccine NN cord-006252-cbelsymu 425 115 on on IN cord-006252-cbelsymu 425 116 theophylline theophylline JJ cord-006252-cbelsymu 425 117 levels level NNS cord-006252-cbelsymu 425 118 and and CC cord-006252-cbelsymu 425 119 warfarin warfarin NN cord-006252-cbelsymu 425 120 anticoagulation anticoagulation NN cord-006252-cbelsymu 425 121 in in IN cord-006252-cbelsymu 425 122 the the DT cord-006252-cbelsymu 425 123 elderly elderly JJ cord-006252-cbelsymu 426 1 The the DT cord-006252-cbelsymu 426 2 effect effect NN cord-006252-cbelsymu 426 3 of of IN cord-006252-cbelsymu 426 4 split split NN cord-006252-cbelsymu 426 5 virus virus NN cord-006252-cbelsymu 426 6 influenza influenza NN cord-006252-cbelsymu 426 7 vaccination vaccination NN cord-006252-cbelsymu 426 8 on on IN cord-006252-cbelsymu 426 9 theophylline theophylline JJ cord-006252-cbelsymu 426 10 pharmacokinetics pharmacokinetics NNP cord-006252-cbelsymu 426 11 Association Association NNP cord-006252-cbelsymu 426 12 of of IN cord-006252-cbelsymu 426 13 in in IN cord-006252-cbelsymu 426 14 fluenza fluenza NNP cord-006252-cbelsymu 426 15 immunization immunization NN cord-006252-cbelsymu 426 16 with with IN cord-006252-cbelsymu 426 17 reduction reduction NN cord-006252-cbelsymu 426 18 in in IN cord-006252-cbelsymu 426 19 mortality mortality NN cord-006252-cbelsymu 426 20 in in IN cord-006252-cbelsymu 426 21 an an DT cord-006252-cbelsymu 426 22 elderly elderly JJ cord-006252-cbelsymu 426 23 population population NN cord-006252-cbelsymu 426 24 : : : cord-006252-cbelsymu 426 25 a a DT cord-006252-cbelsymu 426 26 prospective prospective JJ cord-006252-cbelsymu 426 27 study study NN cord-006252-cbelsymu 426 28 Immunization Immunization NNP cord-006252-cbelsymu 426 29 of of IN cord-006252-cbelsymu 426 30 elderly elderly JJ cord-006252-cbelsymu 426 31 people people NNS cord-006252-cbelsymu 426 32 with with IN cord-006252-cbelsymu 426 33 high high JJ cord-006252-cbelsymu 426 34 doses dose NNS cord-006252-cbelsymu 426 35 of of IN cord-006252-cbelsymu 426 36 influenza influenza JJ cord-006252-cbelsymu 426 37 vaccine vaccine NN cord-006252-cbelsymu 426 38 Relation relation NN cord-006252-cbelsymu 426 39 of of IN cord-006252-cbelsymu 426 40 chronic chronic JJ cord-006252-cbelsymu 426 41 disease disease NN cord-006252-cbelsymu 426 42 and and CC cord-006252-cbelsymu 426 43 immune immune JJ cord-006252-cbelsymu 426 44 response response NN cord-006252-cbelsymu 426 45 to to IN cord-006252-cbelsymu 426 46 influenza influenza NN cord-006252-cbelsymu 426 47 vaccine vaccine NN cord-006252-cbelsymu 426 48 in in IN cord-006252-cbelsymu 426 49 the the DT cord-006252-cbelsymu 426 50 elderly elderly JJ cord-006252-cbelsymu 426 51 Immunization Immunization NNP cord-006252-cbelsymu 426 52 of of IN cord-006252-cbelsymu 426 53 elderly elderly JJ cord-006252-cbelsymu 426 54 people people NNS cord-006252-cbelsymu 426 55 with with IN cord-006252-cbelsymu 426 56 two two CD cord-006252-cbelsymu 426 57 doses dose NNS cord-006252-cbelsymu 426 58 of of IN cord-006252-cbelsymu 426 59 influenza influenza NN cord-006252-cbelsymu 426 60 vaccine vaccine NN cord-006252-cbelsymu 426 61 Effect effect NN cord-006252-cbelsymu 426 62 of of IN cord-006252-cbelsymu 426 63 influenza influenza NN cord-006252-cbelsymu 426 64 vaccine vaccine NN cord-006252-cbelsymu 426 65 on on IN cord-006252-cbelsymu 426 66 serum serum NN cord-006252-cbelsymu 426 67 anticonvulsant anticonvulsant JJ cord-006252-cbelsymu 426 68 concentrations concentration NNS cord-006252-cbelsymu 426 69 Epidemiologic epidemiologic JJ cord-006252-cbelsymu 426 70 implications implication NNS cord-006252-cbelsymu 426 71 of of IN cord-006252-cbelsymu 426 72 changes change NNS cord-006252-cbelsymu 426 73 in in IN cord-006252-cbelsymu 426 74 the the DT cord-006252-cbelsymu 426 75 influenza influenza NN cord-006252-cbelsymu 426 76 virus virus NN cord-006252-cbelsymu 426 77 genome genome NN cord-006252-cbelsymu 426 78 T t NN cord-006252-cbelsymu 426 79 - - HYPH cord-006252-cbelsymu 426 80 cell cell NN cord-006252-cbelsymu 426 81 recognition recognition NN cord-006252-cbelsymu 426 82 of of IN cord-006252-cbelsymu 426 83 influenza influenza NN cord-006252-cbelsymu 426 84 viral viral JJ cord-006252-cbelsymu 426 85 antigens antigen NNS cord-006252-cbelsymu 426 86 Impact Impact NNP cord-006252-cbelsymu 426 87 of of IN cord-006252-cbelsymu 426 88 influenza influenza NN cord-006252-cbelsymu 426 89 epidemic epidemic NN cord-006252-cbelsymu 426 90 on on IN cord-006252-cbelsymu 426 91 mortality mortality NN cord-006252-cbelsymu 426 92 in in IN cord-006252-cbelsymu 426 93 the the DT cord-006252-cbelsymu 426 94 United United NNP cord-006252-cbelsymu 426 95 States States NNP cord-006252-cbelsymu 426 96 from from IN cord-006252-cbelsymu 426 97 Frequency Frequency NNP cord-006252-cbelsymu 426 98 of of IN cord-006252-cbelsymu 426 99 adverse adverse JJ cord-006252-cbelsymu 426 100 reactions reaction NNS cord-006252-cbelsymu 426 101 to to IN cord-006252-cbelsymu 426 102 influenza influenza NN cord-006252-cbelsymu 426 103 vaccine vaccine NN cord-006252-cbelsymu 426 104 in in IN cord-006252-cbelsymu 426 105 the the DT cord-006252-cbelsymu 426 106 elderly elderly JJ cord-006252-cbelsymu 426 107 Frequency Frequency NNP cord-006252-cbelsymu 426 108 of of IN cord-006252-cbelsymu 426 109 adverse adverse JJ cord-006252-cbelsymu 426 110 reactions reaction NNS cord-006252-cbelsymu 426 111 after after IN cord-006252-cbelsymu 426 112 influenza influenza NN cord-006252-cbelsymu 426 113 vaccine vaccine NN cord-006252-cbelsymu 426 114 Effects effect NNS cord-006252-cbelsymu 426 115 of of IN cord-006252-cbelsymu 426 116 influenza influenza NN cord-006252-cbelsymu 426 117 virus virus NN cord-006252-cbelsymu 426 118 vaccine vaccine NN cord-006252-cbelsymu 426 119 on on IN cord-006252-cbelsymu 426 120 hepatic hepatic JJ cord-006252-cbelsymu 426 121 drug drug NN cord-006252-cbelsymu 426 122 metabolism metabolism NN cord-006252-cbelsymu 426 123 Infleunza Infleunza NNP cord-006252-cbelsymu 426 124 : : : cord-006252-cbelsymu 426 125 quantifying quantify VBG cord-006252-cbelsymu 426 126 morbidity morbidity NN cord-006252-cbelsymu 426 127 and and CC cord-006252-cbelsymu 426 128 mortality mortality NN cord-006252-cbelsymu 426 129 Tecumsah Tecumsah NNP cord-006252-cbelsymu 426 130 study study NN cord-006252-cbelsymu 426 131 of of IN cord-006252-cbelsymu 426 132 illness illness NN cord-006252-cbelsymu 426 133 . . . cord-006252-cbelsymu 427 1 XIII XIII NNP cord-006252-cbelsymu 427 2 : : : cord-006252-cbelsymu 428 1 influenza influenza NN cord-006252-cbelsymu 428 2 infection infection NN cord-006252-cbelsymu 428 3 and and CC cord-006252-cbelsymu 428 4 disease disease NN cord-006252-cbelsymu 428 5 Influenza Influenza NNP cord-006252-cbelsymu 428 6 vaccination vaccination NN cord-006252-cbelsymu 428 7 and and CC cord-006252-cbelsymu 428 8 the the DT cord-006252-cbelsymu 428 9 elderly elderly JJ cord-006252-cbelsymu 428 10 Amantadine Amantadine NNP cord-006252-cbelsymu 428 11 for for IN cord-006252-cbelsymu 428 12 influenza influenza NN cord-006252-cbelsymu 428 13 A a DT cord-006252-cbelsymu 428 14 Acute acute JJ cord-006252-cbelsymu 428 15 respiratory respiratory JJ cord-006252-cbelsymu 428 16 disease disease NN cord-006252-cbelsymu 428 17 hospitalizations hospitalization NNS cord-006252-cbelsymu 428 18 as'll as'll NNP cord-006252-cbelsymu 428 19 . . . cord-006252-cbelsymu 429 1 Ijleasure Ijleasure NNP cord-006252-cbelsymu 429 2 of of IN cord-006252-cbelsymu 429 3 impact impact NN cord-006252-cbelsymu 429 4 of of IN cord-006252-cbelsymu 429 5 epidemic epidemic NN cord-006252-cbelsymu 429 6 influenza influenza NN cord-006252-cbelsymu 429 7 Failure failure NN cord-006252-cbelsymu 429 8 to to TO cord-006252-cbelsymu 429 9 respond respond VB cord-006252-cbelsymu 429 10 to to IN cord-006252-cbelsymu 429 11 influenza influenza NN cord-006252-cbelsymu 429 12 vaccine vaccine NN cord-006252-cbelsymu 429 13 in in IN cord-006252-cbelsymu 429 14 the the DT cord-006252-cbelsymu 429 15 aged aged JJ cord-006252-cbelsymu 429 16 : : : cord-006252-cbelsymu 429 17 correlation correlation NN cord-006252-cbelsymu 429 18 with with IN cord-006252-cbelsymu 429 19 B b NN cord-006252-cbelsymu 429 20 - - HYPH cord-006252-cbelsymu 429 21 cell cell NN cord-006252-cbelsymu 429 22 number number NN cord-006252-cbelsymu 429 23 and and CC cord-006252-cbelsymu 429 24 function function VB cord-006252-cbelsymu 429 25 Prevention prevention NN cord-006252-cbelsymu 429 26 and and CC cord-006252-cbelsymu 429 27 control control NN cord-006252-cbelsymu 429 28 of of IN cord-006252-cbelsymu 429 29 influenza influenza NN cord-006252-cbelsymu 429 30 . . . cord-006252-cbelsymu 430 1 And and CC cord-006252-cbelsymu 430 2 addendum addendum NN cord-006252-cbelsymu 430 3 clarification clarification NN cord-006252-cbelsymu 430 4 Economical Economical NNP cord-006252-cbelsymu 430 5 laboratory laboratory NN cord-006252-cbelsymu 430 6 support support NN cord-006252-cbelsymu 430 7 system system NN cord-006252-cbelsymu 430 8 for for IN cord-006252-cbelsymu 430 9 influenza influenza NN cord-006252-cbelsymu 430 10 virus virus NN cord-006252-cbelsymu 430 11 surveillance surveillance NN cord-006252-cbelsymu 430 12 Prevention Prevention NNP cord-006252-cbelsymu 430 13 and and CC cord-006252-cbelsymu 430 14 control control NN cord-006252-cbelsymu 430 15 of of IN cord-006252-cbelsymu 430 16 influenza influenza NN cord-006252-cbelsymu 430 17 : : : cord-006252-cbelsymu 430 18 role role NN cord-006252-cbelsymu 430 19 of of IN cord-006252-cbelsymu 430 20 vaccine vaccine NN cord-006252-cbelsymu 430 21 Economic economic JJ cord-006252-cbelsymu 430 22 impact impact NN cord-006252-cbelsymu 430 23 of of IN cord-006252-cbelsymu 430 24 influenza influenza NN cord-006252-cbelsymu 430 25 : : : cord-006252-cbelsymu 430 26 the the DT cord-006252-cbelsymu 430 27 individual individual NN cord-006252-cbelsymu 430 28 's 's POS cord-006252-cbelsymu 430 29 perspective perspective NN cord-006252-cbelsymu 430 30 Prevention Prevention NNP cord-006252-cbelsymu 430 31 and and CC cord-006252-cbelsymu 430 32 Treatment Treatment NNP cord-006252-cbelsymu 430 33 of of IN cord-006252-cbelsymu 430 34 Influenza Influenza NNP cord-006252-cbelsymu 430 35 population population NN cord-006252-cbelsymu 430 36 : : : cord-006252-cbelsymu 430 37 a a DT cord-006252-cbelsymu 430 38 prospective prospective JJ cord-006252-cbelsymu 430 39 study study NN cord-006252-cbelsymu 430 40 Immunization Immunization NNP cord-006252-cbelsymu 430 41 of of IN cord-006252-cbelsymu 430 42 elderly elderly JJ cord-006252-cbelsymu 430 43 people people NNS cord-006252-cbelsymu 430 44 with with IN cord-006252-cbelsymu 430 45 high high JJ cord-006252-cbelsymu 430 46 doses dose NNS cord-006252-cbelsymu 430 47 of of IN cord-006252-cbelsymu 430 48 influenza influenza JJ cord-006252-cbelsymu 430 49 vaccine vaccine NN cord-006252-cbelsymu 430 50 Relation relation NN cord-006252-cbelsymu 430 51 of of IN cord-006252-cbelsymu 430 52 chronic chronic JJ cord-006252-cbelsymu 430 53 disease disease NN cord-006252-cbelsymu 430 54 and and CC cord-006252-cbelsymu 430 55 immune immune JJ cord-006252-cbelsymu 430 56 response response NN cord-006252-cbelsymu 430 57 to to IN cord-006252-cbelsymu 430 58 influenza influenza NN cord-006252-cbelsymu 430 59 vaccine vaccine NN cord-006252-cbelsymu 430 60 in in IN cord-006252-cbelsymu 430 61 the the DT cord-006252-cbelsymu 430 62 elderly elderly JJ cord-006252-cbelsymu 430 63 Immunization Immunization NNP cord-006252-cbelsymu 430 64 of of IN cord-006252-cbelsymu 430 65 elderly elderly JJ cord-006252-cbelsymu 430 66 people people NNS cord-006252-cbelsymu 430 67 with with IN cord-006252-cbelsymu 430 68 two two CD cord-006252-cbelsymu 430 69 doses dose NNS cord-006252-cbelsymu 430 70 of of IN cord-006252-cbelsymu 430 71 influenza influenza NN cord-006252-cbelsymu 430 72 vaccine vaccine NN cord-006252-cbelsymu 430 73 Effect effect NN cord-006252-cbelsymu 430 74 of of IN cord-006252-cbelsymu 430 75 influenza influenza NN cord-006252-cbelsymu 430 76 vaccine vaccine NN cord-006252-cbelsymu 430 77 on on IN cord-006252-cbelsymu 430 78 serum serum NN cord-006252-cbelsymu 430 79 anticonvulsant anticonvulsant JJ cord-006252-cbelsymu 430 80 concentrations concentration NNS cord-006252-cbelsymu 430 81 Epidemiologic epidemiologic JJ cord-006252-cbelsymu 430 82 implications implication NNS cord-006252-cbelsymu 430 83 of of IN cord-006252-cbelsymu 430 84 changes change NNS cord-006252-cbelsymu 430 85 in in IN cord-006252-cbelsymu 430 86 the the DT cord-006252-cbelsymu 430 87 influenza influenza NN cord-006252-cbelsymu 430 88 virus virus NN cord-006252-cbelsymu 430 89 genome genome NN cord-006252-cbelsymu 430 90 T t NN cord-006252-cbelsymu 430 91 - - HYPH cord-006252-cbelsymu 430 92 cell cell NN cord-006252-cbelsymu 430 93 recognition recognition NN cord-006252-cbelsymu 430 94 of of IN cord-006252-cbelsymu 430 95 influenza influenza NN cord-006252-cbelsymu 430 96 viral viral JJ cord-006252-cbelsymu 430 97 antigens antigen NNS cord-006252-cbelsymu 430 98 Impact Impact NNP cord-006252-cbelsymu 430 99 of of IN cord-006252-cbelsymu 430 100 influenza influenza NN cord-006252-cbelsymu 430 101 epidemic epidemic NN cord-006252-cbelsymu 430 102 on on IN cord-006252-cbelsymu 430 103 mortality mortality NN cord-006252-cbelsymu 430 104 in in IN cord-006252-cbelsymu 430 105 the the DT cord-006252-cbelsymu 430 106 United United NNP cord-006252-cbelsymu 430 107 States States NNP cord-006252-cbelsymu 430 108 from from IN cord-006252-cbelsymu 430 109 Frequency Frequency NNP cord-006252-cbelsymu 430 110 of of IN cord-006252-cbelsymu 430 111 adverse adverse JJ cord-006252-cbelsymu 430 112 reactions reaction NNS cord-006252-cbelsymu 430 113 to to IN cord-006252-cbelsymu 430 114 influenza influenza NN cord-006252-cbelsymu 430 115 vaccine vaccine NN cord-006252-cbelsymu 430 116 in in IN cord-006252-cbelsymu 430 117 the the DT cord-006252-cbelsymu 430 118 elderly elderly JJ cord-006252-cbelsymu 430 119 Frequency Frequency NNP cord-006252-cbelsymu 430 120 of of IN cord-006252-cbelsymu 430 121 adverse adverse JJ cord-006252-cbelsymu 430 122 reactions reaction NNS cord-006252-cbelsymu 430 123 after after IN cord-006252-cbelsymu 430 124 influenza influenza NN cord-006252-cbelsymu 430 125 vaccine vaccine NN cord-006252-cbelsymu 430 126 Effects effect NNS cord-006252-cbelsymu 430 127 of of IN cord-006252-cbelsymu 430 128 influenza influenza NN cord-006252-cbelsymu 430 129 virus virus NN cord-006252-cbelsymu 430 130 vaccine vaccine NN cord-006252-cbelsymu 430 131 on on IN cord-006252-cbelsymu 430 132 hepatic hepatic JJ cord-006252-cbelsymu 430 133 drug drug NN cord-006252-cbelsymu 430 134 metabolism metabolism NN