id	sid	tid	token	lemma	pos
cord-011917-6u0t4hy8	1	1	key	key	JJ
cord-011917-6u0t4hy8	1	2	:	:	:
cord-011917-6u0t4hy8	1	3	cord-011917	cord-011917	NNP
cord-011917-6u0t4hy8	1	4	-	-	HYPH
cord-011917-6u0t4hy8	1	5	6u0t4hy8	6u0t4hy8	CD
cord-011917-6u0t4hy8	1	6	authors	author	NNS
cord-011917-6u0t4hy8	1	7	:	:	:
cord-011917-6u0t4hy8	1	8	Skarlupka	Skarlupka	NNP
cord-011917-6u0t4hy8	1	9	,	,	,
cord-011917-6u0t4hy8	1	10	Amanda	Amanda	NNP
cord-011917-6u0t4hy8	1	11	L.	L.	NNP
cord-011917-6u0t4hy8	1	12	;	;	:
cord-011917-6u0t4hy8	1	13	Ross	Ross	NNP
cord-011917-6u0t4hy8	1	14	,	,	,
cord-011917-6u0t4hy8	1	15	Ted	Ted	NNP
cord-011917-6u0t4hy8	1	16	M.	M.	NNP
cord-011917-6u0t4hy8	1	17	title	title	NN
cord-011917-6u0t4hy8	1	18	:	:	:
cord-011917-6u0t4hy8	1	19	Immune	immune	JJ
cord-011917-6u0t4hy8	1	20	Imprinting	imprinting	NN
cord-011917-6u0t4hy8	1	21	in	in	IN
cord-011917-6u0t4hy8	1	22	the	the	DT
cord-011917-6u0t4hy8	1	23	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	1	24	Ferret	Ferret	NNP
cord-011917-6u0t4hy8	1	25	Model	Model	NNP
cord-011917-6u0t4hy8	1	26	date	date	NN
cord-011917-6u0t4hy8	1	27	:	:	:
cord-011917-6u0t4hy8	1	28	2020	2020	CD
cord-011917-6u0t4hy8	1	29	-	-	HYPH
cord-011917-6u0t4hy8	1	30	04	04	CD
cord-011917-6u0t4hy8	1	31	-	-	HYPH
cord-011917-6u0t4hy8	1	32	08	08	CD
cord-011917-6u0t4hy8	1	33	journal	journal	NN
cord-011917-6u0t4hy8	1	34	:	:	:
cord-011917-6u0t4hy8	1	35	Vaccines	Vaccines	NNP
cord-011917-6u0t4hy8	1	36	(	(	-LRB-
cord-011917-6u0t4hy8	1	37	Basel	Basel	NNP
cord-011917-6u0t4hy8	1	38	)	)	-RRB-
cord-011917-6u0t4hy8	1	39	DOI	DOI	NNP
cord-011917-6u0t4hy8	1	40	:	:	:
cord-011917-6u0t4hy8	2	1	10.3390	10.3390	CD
cord-011917-6u0t4hy8	3	1	/vaccines8020173	/vaccines8020173	.
cord-011917-6u0t4hy8	4	1	sha	sha	NNP
cord-011917-6u0t4hy8	4	2	:	:	:
cord-011917-6u0t4hy8	5	1	918c6b07998eba55ae60af1da72e4d60256298e6	918c6b07998eba55ae60af1da72e4d60256298e6	CD
cord-011917-6u0t4hy8	5	2	doc_id	doc_id	CD
cord-011917-6u0t4hy8	5	3	:	:	:
cord-011917-6u0t4hy8	5	4	11917	11917	CD
cord-011917-6u0t4hy8	5	5	cord_uid	cord_uid	NNS
cord-011917-6u0t4hy8	5	6	:	:	:
cord-011917-6u0t4hy8	5	7	6u0t4hy8	6u0t4hy8	CD
cord-011917-6u0t4hy8	6	1	The	the	DT
cord-011917-6u0t4hy8	6	2	initial	initial	JJ
cord-011917-6u0t4hy8	6	3	exposure	exposure	NN
cord-011917-6u0t4hy8	6	4	to	to	IN
cord-011917-6u0t4hy8	6	5	influenza	influenza	NN
cord-011917-6u0t4hy8	6	6	virus	virus	NN
cord-011917-6u0t4hy8	6	7	usually	usually	RB
cord-011917-6u0t4hy8	6	8	occurs	occur	VBZ
cord-011917-6u0t4hy8	6	9	during	during	IN
cord-011917-6u0t4hy8	6	10	childhood	childhood	NN
cord-011917-6u0t4hy8	6	11	.	.	.
cord-011917-6u0t4hy8	7	1	This	this	DT
cord-011917-6u0t4hy8	7	2	imprinting	imprinting	NN
cord-011917-6u0t4hy8	7	3	has	have	VBZ
cord-011917-6u0t4hy8	7	4	long	long	RB
cord-011917-6u0t4hy8	7	5	-	-	HYPH
cord-011917-6u0t4hy8	7	6	lasting	last	VBG
cord-011917-6u0t4hy8	7	7	effects	effect	NNS
cord-011917-6u0t4hy8	7	8	on	on	IN
cord-011917-6u0t4hy8	7	9	the	the	DT
cord-011917-6u0t4hy8	7	10	immune	immune	JJ
cord-011917-6u0t4hy8	7	11	responses	response	NNS
cord-011917-6u0t4hy8	7	12	to	to	IN
cord-011917-6u0t4hy8	7	13	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	7	14	infections	infection	NNS
cord-011917-6u0t4hy8	7	15	and	and	CC
cord-011917-6u0t4hy8	7	16	vaccinations	vaccination	NNS
cord-011917-6u0t4hy8	7	17	.	.	.
cord-011917-6u0t4hy8	8	1	Animal	animal	NN
cord-011917-6u0t4hy8	8	2	models	model	NNS
cord-011917-6u0t4hy8	8	3	that	that	WDT
cord-011917-6u0t4hy8	8	4	are	be	VBP
cord-011917-6u0t4hy8	8	5	used	use	VBN
cord-011917-6u0t4hy8	8	6	to	to	TO
cord-011917-6u0t4hy8	8	7	investigate	investigate	VB
cord-011917-6u0t4hy8	8	8	influenza	influenza	NN
cord-011917-6u0t4hy8	8	9	pathogenesis	pathogenesis	NN
cord-011917-6u0t4hy8	8	10	and	and	CC
cord-011917-6u0t4hy8	8	11	vaccination	vaccination	NN
cord-011917-6u0t4hy8	8	12	do	do	VBP
cord-011917-6u0t4hy8	8	13	recapitulate	recapitulate	VB
cord-011917-6u0t4hy8	8	14	the	the	DT
cord-011917-6u0t4hy8	8	15	pre	pre	JJ
cord-011917-6u0t4hy8	8	16	-	-	JJ
cord-011917-6u0t4hy8	8	17	immune	immune	JJ
cord-011917-6u0t4hy8	8	18	history	history	NN
cord-011917-6u0t4hy8	8	19	in	in	IN
cord-011917-6u0t4hy8	8	20	the	the	DT
cord-011917-6u0t4hy8	8	21	human	human	JJ
cord-011917-6u0t4hy8	8	22	population	population	NN
cord-011917-6u0t4hy8	8	23	.	.	.
cord-011917-6u0t4hy8	9	1	The	the	DT
cord-011917-6u0t4hy8	9	2	establishment	establishment	NN
cord-011917-6u0t4hy8	9	3	of	of	IN
cord-011917-6u0t4hy8	9	4	influenza	influenza	NN
cord-011917-6u0t4hy8	9	5	pre	pre	JJ
cord-011917-6u0t4hy8	9	6	-	-	JJ
cord-011917-6u0t4hy8	9	7	immune	immune	JJ
cord-011917-6u0t4hy8	9	8	ferret	ferret	NN
cord-011917-6u0t4hy8	9	9	models	model	NNS
cord-011917-6u0t4hy8	9	10	is	be	VBZ
cord-011917-6u0t4hy8	9	11	necessary	necessary	JJ
cord-011917-6u0t4hy8	9	12	for	for	IN
cord-011917-6u0t4hy8	9	13	understanding	understand	VBG
cord-011917-6u0t4hy8	9	14	infection	infection	NN
cord-011917-6u0t4hy8	9	15	and	and	CC
cord-011917-6u0t4hy8	9	16	transmission	transmission	NN
cord-011917-6u0t4hy8	9	17	and	and	CC
cord-011917-6u0t4hy8	9	18	for	for	IN
cord-011917-6u0t4hy8	9	19	designing	design	VBG
cord-011917-6u0t4hy8	9	20	efficacious	efficacious	JJ
cord-011917-6u0t4hy8	9	21	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	9	22	.	.	.
cord-011917-6u0t4hy8	10	1	Nearly	nearly	RB
cord-011917-6u0t4hy8	10	2	500,000	500,000	CD
cord-011917-6u0t4hy8	10	3	annual	annual	JJ
cord-011917-6u0t4hy8	10	4	global	global	JJ
cord-011917-6u0t4hy8	10	5	deaths	death	NNS
cord-011917-6u0t4hy8	10	6	are	be	VBP
cord-011917-6u0t4hy8	10	7	attributed	attribute	VBN
cord-011917-6u0t4hy8	10	8	to	to	IN
cord-011917-6u0t4hy8	10	9	influenza	influenza	NN
cord-011917-6u0t4hy8	10	10	virus	virus	NN
cord-011917-6u0t4hy8	10	11	infection	infection	NN
cord-011917-6u0t4hy8	10	12	[	[	-LRB-
cord-011917-6u0t4hy8	10	13	1	1	CD
cord-011917-6u0t4hy8	10	14	]	]	-RRB-
cord-011917-6u0t4hy8	10	15	.	.	.
cord-011917-6u0t4hy8	11	1	The	the	DT
cord-011917-6u0t4hy8	11	2	influenza	influenza	NN
cord-011917-6u0t4hy8	11	3	virus	virus	NN
cord-011917-6u0t4hy8	11	4	consists	consist	VBZ
cord-011917-6u0t4hy8	11	5	of	of	IN
cord-011917-6u0t4hy8	11	6	four	four	CD
cord-011917-6u0t4hy8	11	7	different	different	JJ
cord-011917-6u0t4hy8	11	8	types	type	NNS
cord-011917-6u0t4hy8	11	9	(	(	-LRB-
cord-011917-6u0t4hy8	11	10	A	A	NNP
cord-011917-6u0t4hy8	11	11	,	,	,
cord-011917-6u0t4hy8	11	12	B	B	NNP
cord-011917-6u0t4hy8	11	13	,	,	,
cord-011917-6u0t4hy8	11	14	C	C	NNP
cord-011917-6u0t4hy8	11	15	,	,	,
cord-011917-6u0t4hy8	11	16	D	D	NNP
cord-011917-6u0t4hy8	11	17	)	)	-RRB-
cord-011917-6u0t4hy8	11	18	with	with	IN
cord-011917-6u0t4hy8	11	19	Types	type	NNS
cord-011917-6u0t4hy8	11	20	A	A	NNP
cord-011917-6u0t4hy8	11	21	and	and	CC
cord-011917-6u0t4hy8	11	22	B	b	NN
cord-011917-6u0t4hy8	11	23	causing	cause	VBG
cord-011917-6u0t4hy8	11	24	symptoms	symptom	NNS
cord-011917-6u0t4hy8	11	25	in	in	IN
cord-011917-6u0t4hy8	11	26	humans	human	NNS
cord-011917-6u0t4hy8	11	27	.	.	.
cord-011917-6u0t4hy8	12	1	These	these	DT
cord-011917-6u0t4hy8	12	2	two	two	CD
cord-011917-6u0t4hy8	12	3	types	type	NNS
cord-011917-6u0t4hy8	12	4	are	be	VBP
cord-011917-6u0t4hy8	12	5	further	further	RB
cord-011917-6u0t4hy8	12	6	classified	classify	VBN
cord-011917-6u0t4hy8	12	7	into	into	IN
cord-011917-6u0t4hy8	12	8	subtypes	subtype	NNS
cord-011917-6u0t4hy8	12	9	and	and	CC
cord-011917-6u0t4hy8	12	10	sub	sub	NN
cord-011917-6u0t4hy8	12	11	-	-	NNS
cord-011917-6u0t4hy8	12	12	lineages	lineage	NNS
cord-011917-6u0t4hy8	12	13	,	,	,
cord-011917-6u0t4hy8	12	14	respectively	respectively	RB
cord-011917-6u0t4hy8	12	15	.	.	.
cord-011917-6u0t4hy8	13	1	The	the	DT
cord-011917-6u0t4hy8	13	2	surface	surface	NN
cord-011917-6u0t4hy8	13	3	of	of	IN
cord-011917-6u0t4hy8	13	4	the	the	DT
cord-011917-6u0t4hy8	13	5	influenza	influenza	NN
cord-011917-6u0t4hy8	13	6	virion	virion	NN
cord-011917-6u0t4hy8	13	7	consists	consist	VBZ
cord-011917-6u0t4hy8	13	8	of	of	IN
cord-011917-6u0t4hy8	13	9	two	two	CD
cord-011917-6u0t4hy8	13	10	major	major	JJ
cord-011917-6u0t4hy8	13	11	glycoproteins	glycoprotein	NNS
cord-011917-6u0t4hy8	13	12	the	the	DT
cord-011917-6u0t4hy8	13	13	hemagglutinin	hemagglutinin	NN
cord-011917-6u0t4hy8	13	14	(	(	-LRB-
cord-011917-6u0t4hy8	13	15	HA	HA	NNP
cord-011917-6u0t4hy8	13	16	;	;	:
cord-011917-6u0t4hy8	13	17	Type	type	NN
cord-011917-6u0t4hy8	13	18	A	a	NN
cord-011917-6u0t4hy8	13	19	:	:	:
cord-011917-6u0t4hy8	13	20	H1-H18	H1-H18	NNP
cord-011917-6u0t4hy8	13	21	;	;	:
cord-011917-6u0t4hy8	13	22	Type	type	NN
cord-011917-6u0t4hy8	13	23	B	B	NNP
cord-011917-6u0t4hy8	13	24	:	:	:
cord-011917-6u0t4hy8	13	25	Yamagata-	Yamagata-	NNP
cord-011917-6u0t4hy8	13	26	,	,	,
cord-011917-6u0t4hy8	13	27	Victoria	Victoria	NNP
cord-011917-6u0t4hy8	13	28	-	-	HYPH
cord-011917-6u0t4hy8	13	29	lineage	lineage	NN
cord-011917-6u0t4hy8	13	30	)	)	-RRB-
cord-011917-6u0t4hy8	13	31	and	and	CC
cord-011917-6u0t4hy8	13	32	the	the	DT
cord-011917-6u0t4hy8	13	33	neuraminidase	neuraminidase	NN
cord-011917-6u0t4hy8	13	34	(	(	-LRB-
cord-011917-6u0t4hy8	13	35	NA	NA	NNP
cord-011917-6u0t4hy8	13	36	;	;	:
cord-011917-6u0t4hy8	13	37	Type	type	NN
cord-011917-6u0t4hy8	13	38	A	a	NN
cord-011917-6u0t4hy8	13	39	:	:	:
cord-011917-6u0t4hy8	13	40	N1-N11	N1-N11	NNP
cord-011917-6u0t4hy8	13	41	)	)	-RRB-
cord-011917-6u0t4hy8	13	42	,	,	,
cord-011917-6u0t4hy8	13	43	each	each	DT
cord-011917-6u0t4hy8	13	44	of	of	IN
cord-011917-6u0t4hy8	13	45	which	which	WDT
cord-011917-6u0t4hy8	13	46	are	be	VBP
cord-011917-6u0t4hy8	13	47	separated	separate	VBN
cord-011917-6u0t4hy8	13	48	into	into	IN
cord-011917-6u0t4hy8	13	49	antigenically	antigenically	RB
cord-011917-6u0t4hy8	13	50	distinct	distinct	JJ
cord-011917-6u0t4hy8	13	51	subtypes	subtype	NNS
cord-011917-6u0t4hy8	13	52	and	and	CC
cord-011917-6u0t4hy8	13	53	together	together	RB
cord-011917-6u0t4hy8	13	54	denote	denote	VB
cord-011917-6u0t4hy8	13	55	viral	viral	JJ
cord-011917-6u0t4hy8	13	56	subtypes	subtype	NNS
cord-011917-6u0t4hy8	13	57	[	[	-LRB-
cord-011917-6u0t4hy8	13	58	2	2	CD
cord-011917-6u0t4hy8	13	59	]	]	-RRB-
cord-011917-6u0t4hy8	13	60	.	.	.
cord-011917-6u0t4hy8	14	1	The	the	DT
cord-011917-6u0t4hy8	14	2	glycoproteins	glycoprotein	NNS
cord-011917-6u0t4hy8	14	3	undergo	undergo	VBP
cord-011917-6u0t4hy8	14	4	independent	independent	JJ
cord-011917-6u0t4hy8	14	5	evolution	evolution	NN
cord-011917-6u0t4hy8	14	6	leading	lead	VBG
cord-011917-6u0t4hy8	14	7	to	to	IN
cord-011917-6u0t4hy8	14	8	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	14	9	drift	drift	NN
cord-011917-6u0t4hy8	14	10	as	as	IN
cord-011917-6u0t4hy8	14	11	the	the	DT
cord-011917-6u0t4hy8	14	12	virus	virus	NN
cord-011917-6u0t4hy8	14	13	accumulates	accumulate	VBZ
cord-011917-6u0t4hy8	14	14	mutations	mutation	NNS
cord-011917-6u0t4hy8	14	15	over	over	IN
cord-011917-6u0t4hy8	14	16	time	time	NN
cord-011917-6u0t4hy8	14	17	.	.	.
cord-011917-6u0t4hy8	15	1	The	the	DT
cord-011917-6u0t4hy8	15	2	HA	HA	NNP
cord-011917-6u0t4hy8	15	3	and	and	CC
cord-011917-6u0t4hy8	15	4	NA	NA	NNP
cord-011917-6u0t4hy8	15	5	gene	gene	NN
cord-011917-6u0t4hy8	15	6	segments	segment	NNS
cord-011917-6u0t4hy8	15	7	reassort	reassort	NNP
cord-011917-6u0t4hy8	15	8	due	due	IN
cord-011917-6u0t4hy8	15	9	to	to	IN
cord-011917-6u0t4hy8	15	10	the	the	DT
cord-011917-6u0t4hy8	15	11	segmented	segmented	JJ
cord-011917-6u0t4hy8	15	12	nature	nature	NN
cord-011917-6u0t4hy8	15	13	of	of	IN
cord-011917-6u0t4hy8	15	14	the	the	DT
cord-011917-6u0t4hy8	15	15	viral	viral	JJ
cord-011917-6u0t4hy8	15	16	RNA	RNA	NNP
cord-011917-6u0t4hy8	15	17	genome	genome	NN
cord-011917-6u0t4hy8	15	18	,	,	,
cord-011917-6u0t4hy8	15	19	leading	lead	VBG
cord-011917-6u0t4hy8	15	20	to	to	IN
cord-011917-6u0t4hy8	15	21	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	15	22	shifts	shift	NNS
cord-011917-6u0t4hy8	15	23	.	.	.
cord-011917-6u0t4hy8	16	1	These	these	DT
cord-011917-6u0t4hy8	16	2	shifts	shift	NNS
cord-011917-6u0t4hy8	16	3	are	be	VBP
cord-011917-6u0t4hy8	16	4	unprecedented	unprecedented	JJ
cord-011917-6u0t4hy8	16	5	and	and	CC
cord-011917-6u0t4hy8	16	6	are	be	VBP
cord-011917-6u0t4hy8	16	7	often	often	RB
cord-011917-6u0t4hy8	16	8	met	meet	VBN
cord-011917-6u0t4hy8	16	9	with	with	IN
cord-011917-6u0t4hy8	16	10	no	no	DT
cord-011917-6u0t4hy8	16	11	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	16	12	antibodies	antibody	NNS
cord-011917-6u0t4hy8	16	13	in	in	IN
cord-011917-6u0t4hy8	16	14	the	the	DT
cord-011917-6u0t4hy8	16	15	human	human	JJ
cord-011917-6u0t4hy8	16	16	population	population	NN
cord-011917-6u0t4hy8	16	17	,	,	,
cord-011917-6u0t4hy8	16	18	leading	lead	VBG
cord-011917-6u0t4hy8	16	19	to	to	IN
cord-011917-6u0t4hy8	16	20	heightened	heighten	VBN
cord-011917-6u0t4hy8	16	21	pandemic	pandemic	NN
cord-011917-6u0t4hy8	16	22	potential	potential	NN
cord-011917-6u0t4hy8	16	23	.	.	.
cord-011917-6u0t4hy8	17	1	Within	within	IN
cord-011917-6u0t4hy8	17	2	subtypes	subtype	NNS
cord-011917-6u0t4hy8	17	3	,	,	,
cord-011917-6u0t4hy8	17	4	there	there	EX
cord-011917-6u0t4hy8	17	5	can	can	MD
cord-011917-6u0t4hy8	17	6	be	be	VB
cord-011917-6u0t4hy8	17	7	distinct	distinct	JJ
cord-011917-6u0t4hy8	17	8	shifts	shift	NNS
cord-011917-6u0t4hy8	17	9	in	in	IN
cord-011917-6u0t4hy8	17	10	antigenicity	antigenicity	NN
cord-011917-6u0t4hy8	17	11	,	,	,
cord-011917-6u0t4hy8	17	12	such	such	JJ
cord-011917-6u0t4hy8	17	13	as	as	IN
cord-011917-6u0t4hy8	17	14	with	with	IN
cord-011917-6u0t4hy8	17	15	the	the	DT
cord-011917-6u0t4hy8	17	16	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	17	17	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	17	18	)	)	-RRB-
cord-011917-6u0t4hy8	17	19	which	which	WDT
cord-011917-6u0t4hy8	17	20	circulated	circulate	VBD
cord-011917-6u0t4hy8	17	21	in	in	IN
cord-011917-6u0t4hy8	17	22	humans	human	NNS
cord-011917-6u0t4hy8	17	23	until	until	IN
cord-011917-6u0t4hy8	17	24	the	the	DT
cord-011917-6u0t4hy8	17	25	emergence	emergence	NN
cord-011917-6u0t4hy8	17	26	of	of	IN
cord-011917-6u0t4hy8	17	27	the	the	DT
cord-011917-6u0t4hy8	17	28	swine	swine	NN
cord-011917-6u0t4hy8	17	29	-	-	HYPH
cord-011917-6u0t4hy8	17	30	origin	origin	NN
cord-011917-6u0t4hy8	17	31	2009	2009	CD
cord-011917-6u0t4hy8	17	32	pandemic	pandemic	NN
cord-011917-6u0t4hy8	17	33	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	17	34	)	)	-RRB-
cord-011917-6u0t4hy8	17	35	.	.	.
cord-011917-6u0t4hy8	18	1	The	the	DT
cord-011917-6u0t4hy8	18	2	surrogates	surrogate	NNS
cord-011917-6u0t4hy8	18	3	of	of	IN
cord-011917-6u0t4hy8	18	4	protection	protection	NN
cord-011917-6u0t4hy8	18	5	,	,	,
cord-011917-6u0t4hy8	18	6	induced	induce	VBN
cord-011917-6u0t4hy8	18	7	either	either	CC
cord-011917-6u0t4hy8	18	8	through	through	IN
cord-011917-6u0t4hy8	18	9	infection	infection	NN
cord-011917-6u0t4hy8	18	10	or	or	CC
cord-011917-6u0t4hy8	18	11	vaccination	vaccination	NN
cord-011917-6u0t4hy8	18	12	,	,	,
cord-011917-6u0t4hy8	18	13	rely	rely	VBP
cord-011917-6u0t4hy8	18	14	on	on	IN
cord-011917-6u0t4hy8	18	15	serological	serological	JJ
cord-011917-6u0t4hy8	18	16	assays	assay	NNS
cord-011917-6u0t4hy8	18	17	that	that	WDT
cord-011917-6u0t4hy8	18	18	are	be	VBP
cord-011917-6u0t4hy8	18	19	dependent	dependent	JJ
cord-011917-6u0t4hy8	18	20	on	on	IN
cord-011917-6u0t4hy8	18	21	the	the	DT
cord-011917-6u0t4hy8	18	22	presence	presence	NN
cord-011917-6u0t4hy8	18	23	of	of	IN
cord-011917-6u0t4hy8	18	24	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	18	25	antibodies	antibody	NNS
cord-011917-6u0t4hy8	18	26	to	to	IN
cord-011917-6u0t4hy8	18	27	mainly	mainly	RB
cord-011917-6u0t4hy8	18	28	the	the	DT
cord-011917-6u0t4hy8	18	29	HA	HA	NNP
cord-011917-6u0t4hy8	18	30	glycoprotein	glycoprotein	NN
cord-011917-6u0t4hy8	18	31	:	:	:
cord-011917-6u0t4hy8	18	32	hemagglutination	hemagglutination	NN
cord-011917-6u0t4hy8	18	33	inhibition	inhibition	NN
cord-011917-6u0t4hy8	18	34	,	,	,
cord-011917-6u0t4hy8	18	35	single	single	JJ
cord-011917-6u0t4hy8	18	36	radial	radial	JJ
cord-011917-6u0t4hy8	18	37	hemolysis	hemolysis	NN
cord-011917-6u0t4hy8	18	38	,	,	,
cord-011917-6u0t4hy8	18	39	and	and	CC
cord-011917-6u0t4hy8	18	40	microneutralization	microneutralization	NN
cord-011917-6u0t4hy8	18	41	[	[	-LRB-
cord-011917-6u0t4hy8	18	42	3	3	CD
cord-011917-6u0t4hy8	18	43	]	]	-RRB-
cord-011917-6u0t4hy8	18	44	.	.	.
cord-011917-6u0t4hy8	19	1	Initial	initial	JJ
cord-011917-6u0t4hy8	19	2	exposure	exposure	NN
cord-011917-6u0t4hy8	19	3	to	to	IN
cord-011917-6u0t4hy8	19	4	influenza	influenza	NN
cord-011917-6u0t4hy8	19	5	occurs	occur	VBZ
cord-011917-6u0t4hy8	19	6	during	during	IN
cord-011917-6u0t4hy8	19	7	childhood	childhood	NN
cord-011917-6u0t4hy8	19	8	;	;	:
cord-011917-6u0t4hy8	19	9	at	at	IN
cord-011917-6u0t4hy8	19	10	six	six	CD
cord-011917-6u0t4hy8	19	11	to	to	TO
cord-011917-6u0t4hy8	19	12	nine	nine	CD
cord-011917-6u0t4hy8	19	13	years	year	NNS
cord-011917-6u0t4hy8	19	14	old	old	JJ
cord-011917-6u0t4hy8	19	15	,	,	,
cord-011917-6u0t4hy8	19	16	80	80	CD
cord-011917-6u0t4hy8	19	17	%	%	NN
cord-011917-6u0t4hy8	19	18	of	of	IN
cord-011917-6u0t4hy8	19	19	children	child	NNS
cord-011917-6u0t4hy8	19	20	were	be	VBD
cord-011917-6u0t4hy8	19	21	seropositive	seropositive	JJ
cord-011917-6u0t4hy8	19	22	to	to	IN
cord-011917-6u0t4hy8	19	23	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	19	24	)	)	-RRB-
cord-011917-6u0t4hy8	20	1	[	[	-LRB-
cord-011917-6u0t4hy8	20	2	4	4	CD
cord-011917-6u0t4hy8	20	3	]	]	-RRB-
cord-011917-6u0t4hy8	20	4	.	.	.
cord-011917-6u0t4hy8	21	1	This	this	DT
cord-011917-6u0t4hy8	21	2	initial	initial	JJ
cord-011917-6u0t4hy8	21	3	infection	infection	NN
cord-011917-6u0t4hy8	21	4	primes	prime	VBZ
cord-011917-6u0t4hy8	21	5	the	the	DT
cord-011917-6u0t4hy8	21	6	immune	immune	JJ
cord-011917-6u0t4hy8	21	7	system	system	NN
cord-011917-6u0t4hy8	21	8	and	and	CC
cord-011917-6u0t4hy8	21	9	biases	bias	NNS
cord-011917-6u0t4hy8	21	10	future	future	JJ
cord-011917-6u0t4hy8	21	11	immune	immune	JJ
cord-011917-6u0t4hy8	21	12	responses	response	NNS
cord-011917-6u0t4hy8	21	13	to	to	IN
cord-011917-6u0t4hy8	21	14	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	21	15	infections	infection	NNS
cord-011917-6u0t4hy8	21	16	and	and	CC
cord-011917-6u0t4hy8	21	17	vaccinations	vaccination	NNS
cord-011917-6u0t4hy8	21	18	[	[	-LRB-
cord-011917-6u0t4hy8	21	19	5	5	CD
cord-011917-6u0t4hy8	21	20	]	]	-RRB-
cord-011917-6u0t4hy8	21	21	[	[	-LRB-
cord-011917-6u0t4hy8	21	22	6	6	CD
cord-011917-6u0t4hy8	21	23	]	]	-RRB-
cord-011917-6u0t4hy8	21	24	[	[	-LRB-
cord-011917-6u0t4hy8	21	25	7	7	CD
cord-011917-6u0t4hy8	21	26	]	]	-RRB-
cord-011917-6u0t4hy8	22	1	[	[	-LRB-
cord-011917-6u0t4hy8	22	2	8	8	CD
cord-011917-6u0t4hy8	22	3	]	]	-RRB-
cord-011917-6u0t4hy8	22	4	[	[	-LRB-
cord-011917-6u0t4hy8	22	5	9	9	CD
cord-011917-6u0t4hy8	22	6	]	]	-RRB-
cord-011917-6u0t4hy8	22	7	[	[	-LRB-
cord-011917-6u0t4hy8	22	8	10	10	CD
cord-011917-6u0t4hy8	22	9	]	]	-RRB-
cord-011917-6u0t4hy8	22	10	[	[	-LRB-
cord-011917-6u0t4hy8	22	11	11	11	CD
cord-011917-6u0t4hy8	22	12	]	]	-RRB-
cord-011917-6u0t4hy8	22	13	.	.	.
cord-011917-6u0t4hy8	23	1	Due	due	IN
cord-011917-6u0t4hy8	23	2	to	to	IN
cord-011917-6u0t4hy8	23	3	the	the	DT
cord-011917-6u0t4hy8	23	4	cost	cost	NN
cord-011917-6u0t4hy8	23	5	and	and	CC
cord-011917-6u0t4hy8	23	6	resources	resource	NNS
cord-011917-6u0t4hy8	23	7	of	of	IN
cord-011917-6u0t4hy8	23	8	human	human	JJ
cord-011917-6u0t4hy8	23	9	clinical	clinical	JJ
cord-011917-6u0t4hy8	23	10	trials	trial	NNS
cord-011917-6u0t4hy8	23	11	,	,	,
cord-011917-6u0t4hy8	23	12	there	there	EX
cord-011917-6u0t4hy8	23	13	are	be	VBP
cord-011917-6u0t4hy8	23	14	numerous	numerous	JJ
cord-011917-6u0t4hy8	23	15	animal	animal	NN
cord-011917-6u0t4hy8	23	16	models	model	NNS
cord-011917-6u0t4hy8	23	17	designed	design	VBN
cord-011917-6u0t4hy8	23	18	to	to	TO
cord-011917-6u0t4hy8	23	19	study	study	VB
cord-011917-6u0t4hy8	23	20	this	this	DT
cord-011917-6u0t4hy8	23	21	viral	viral	JJ
cord-011917-6u0t4hy8	23	22	pathogen	pathogen	NN
cord-011917-6u0t4hy8	23	23	[	[	-LRB-
cord-011917-6u0t4hy8	23	24	12	12	CD
cord-011917-6u0t4hy8	23	25	]	]	-RRB-
cord-011917-6u0t4hy8	23	26	.	.	.
cord-011917-6u0t4hy8	24	1	The	the	DT
cord-011917-6u0t4hy8	24	2	ferret	ferret	NN
cord-011917-6u0t4hy8	24	3	model	model	NN
cord-011917-6u0t4hy8	24	4	remains	remain	VBZ
cord-011917-6u0t4hy8	24	5	indispensable	indispensable	JJ
cord-011917-6u0t4hy8	24	6	due	due	IN
cord-011917-6u0t4hy8	24	7	to	to	IN
cord-011917-6u0t4hy8	24	8	similarities	similarity	NNS
cord-011917-6u0t4hy8	24	9	in	in	IN
cord-011917-6u0t4hy8	24	10	lung	lung	NN
cord-011917-6u0t4hy8	24	11	physiology	physiology	NN
cord-011917-6u0t4hy8	24	12	[	[	-LRB-
cord-011917-6u0t4hy8	24	13	13	13	CD
cord-011917-6u0t4hy8	24	14	,	,	,
cord-011917-6u0t4hy8	24	15	14	14	CD
cord-011917-6u0t4hy8	24	16	]	]	-RRB-
cord-011917-6u0t4hy8	24	17	,	,	,
cord-011917-6u0t4hy8	24	18	anatomical	anatomical	JJ
cord-011917-6u0t4hy8	24	19	distribution	distribution	NN
cord-011917-6u0t4hy8	24	20	of	of	IN
cord-011917-6u0t4hy8	24	21	sialylated	sialylated	JJ
cord-011917-6u0t4hy8	24	22	glycan	glycan	NN
cord-011917-6u0t4hy8	24	23	receptors	receptor	NNS
cord-011917-6u0t4hy8	24	24	[	[	-LRB-
cord-011917-6u0t4hy8	24	25	15	15	CD
cord-011917-6u0t4hy8	24	26	]	]	-RRB-
cord-011917-6u0t4hy8	24	27	,	,	,
cord-011917-6u0t4hy8	24	28	and	and	CC
cord-011917-6u0t4hy8	24	29	glycomic	glycomic	JJ
cord-011917-6u0t4hy8	24	30	profile	profile	NN
cord-011917-6u0t4hy8	24	31	of	of	IN
cord-011917-6u0t4hy8	24	32	ferret	ferret	JJ
cord-011917-6u0t4hy8	24	33	respiratory	respiratory	JJ
cord-011917-6u0t4hy8	24	34	tissues	tissue	NNS
cord-011917-6u0t4hy8	24	35	[	[	-LRB-
cord-011917-6u0t4hy8	24	36	16	16	CD
cord-011917-6u0t4hy8	24	37	,	,	,
cord-011917-6u0t4hy8	24	38	17	17	CD
cord-011917-6u0t4hy8	24	39	]	]	-RRB-
cord-011917-6u0t4hy8	24	40	.	.	.
cord-011917-6u0t4hy8	25	1	These	these	DT
cord-011917-6u0t4hy8	25	2	animal	animal	NN
cord-011917-6u0t4hy8	25	3	models	model	NNS
cord-011917-6u0t4hy8	25	4	are	be	VBP
cord-011917-6u0t4hy8	25	5	commonly	commonly	RB
cord-011917-6u0t4hy8	25	6	used	use	VBN
cord-011917-6u0t4hy8	25	7	to	to	TO
cord-011917-6u0t4hy8	25	8	study	study	VB
cord-011917-6u0t4hy8	25	9	viral	viral	JJ
cord-011917-6u0t4hy8	25	10	characteristics	characteristic	NNS
cord-011917-6u0t4hy8	25	11	,	,	,
cord-011917-6u0t4hy8	25	12	host	host	NN
cord-011917-6u0t4hy8	25	13	immune	immune	JJ
cord-011917-6u0t4hy8	25	14	responses	response	NNS
cord-011917-6u0t4hy8	25	15	,	,	,
cord-011917-6u0t4hy8	25	16	and	and	CC
cord-011917-6u0t4hy8	25	17	vaccine	vaccine	NN
cord-011917-6u0t4hy8	25	18	/	/	SYM
cord-011917-6u0t4hy8	25	19	antiviral	antiviral	JJ
cord-011917-6u0t4hy8	25	20	therapies	therapy	NNS
cord-011917-6u0t4hy8	25	21	.	.	.
cord-011917-6u0t4hy8	26	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	26	2	,	,	,
cord-011917-6u0t4hy8	26	3	animal	animal	NN
cord-011917-6u0t4hy8	26	4	models	model	NNS
cord-011917-6u0t4hy8	26	5	that	that	WDT
cord-011917-6u0t4hy8	26	6	mimic	mimic	VBP
cord-011917-6u0t4hy8	26	7	pre	pre	JJ
cord-011917-6u0t4hy8	26	8	-	-	JJ
cord-011917-6u0t4hy8	26	9	existing	existing	JJ
cord-011917-6u0t4hy8	26	10	human	human	JJ
cord-011917-6u0t4hy8	26	11	immunity	immunity	NN
cord-011917-6u0t4hy8	26	12	to	to	IN
cord-011917-6u0t4hy8	26	13	influenza	influenza	NN
cord-011917-6u0t4hy8	26	14	viruses	virus	NNS
cord-011917-6u0t4hy8	26	15	may	may	MD
cord-011917-6u0t4hy8	26	16	better	better	RB
cord-011917-6u0t4hy8	26	17	represent	represent	VB
cord-011917-6u0t4hy8	26	18	the	the	DT
cord-011917-6u0t4hy8	26	19	human	human	JJ
cord-011917-6u0t4hy8	26	20	immune	immune	JJ
cord-011917-6u0t4hy8	26	21	responses	response	NNS
cord-011917-6u0t4hy8	26	22	to	to	IN
cord-011917-6u0t4hy8	26	23	infection	infection	NN
cord-011917-6u0t4hy8	26	24	and	and	CC
cord-011917-6u0t4hy8	26	25	vaccination	vaccination	NN
cord-011917-6u0t4hy8	26	26	.	.	.
cord-011917-6u0t4hy8	27	1	The	the	DT
cord-011917-6u0t4hy8	27	2	current	current	JJ
cord-011917-6u0t4hy8	27	3	preventative	preventative	JJ
cord-011917-6u0t4hy8	27	4	method	method	NN
cord-011917-6u0t4hy8	27	5	used	use	VBN
cord-011917-6u0t4hy8	27	6	to	to	TO
cord-011917-6u0t4hy8	27	7	combat	combat	VB
cord-011917-6u0t4hy8	27	8	influenza	influenza	NN
cord-011917-6u0t4hy8	27	9	is	be	VBZ
cord-011917-6u0t4hy8	27	10	vaccination	vaccination	NN
cord-011917-6u0t4hy8	27	11	.	.	.
cord-011917-6u0t4hy8	28	1	Administered	administer	VBN
cord-011917-6u0t4hy8	28	2	annually	annually	RB
cord-011917-6u0t4hy8	28	3	,	,	,
cord-011917-6u0t4hy8	28	4	the	the	DT
cord-011917-6u0t4hy8	28	5	most	most	RBS
cord-011917-6u0t4hy8	28	6	common	common	JJ
cord-011917-6u0t4hy8	28	7	intramuscular	intramuscular	JJ
cord-011917-6u0t4hy8	28	8	split	split	NN
cord-011917-6u0t4hy8	28	9	-	-	HYPH
cord-011917-6u0t4hy8	28	10	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	28	11	cell	cell	NN
cord-011917-6u0t4hy8	28	12	-	-	HYPH
cord-011917-6u0t4hy8	28	13	based	base	VBN
cord-011917-6u0t4hy8	28	14	influenza	influenza	NN
cord-011917-6u0t4hy8	28	15	vaccine	vaccine	NN
cord-011917-6u0t4hy8	28	16	is	be	VBZ
cord-011917-6u0t4hy8	28	17	composed	compose	VBN
cord-011917-6u0t4hy8	28	18	of	of	IN
cord-011917-6u0t4hy8	28	19	four	four	CD
cord-011917-6u0t4hy8	28	20	viral	viral	JJ
cord-011917-6u0t4hy8	28	21	strains	strain	NNS
cord-011917-6u0t4hy8	28	22	,	,	,
cord-011917-6u0t4hy8	28	23	an	an	DT
cord-011917-6u0t4hy8	28	24	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	28	25	)	)	-RRB-
cord-011917-6u0t4hy8	28	26	,	,	,
cord-011917-6u0t4hy8	28	27	an	an	DT
cord-011917-6u0t4hy8	28	28	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	28	29	)	)	-RRB-
cord-011917-6u0t4hy8	28	30	,	,	,
cord-011917-6u0t4hy8	28	31	and	and	CC
cord-011917-6u0t4hy8	28	32	two	two	CD
cord-011917-6u0t4hy8	28	33	type	type	NN
cord-011917-6u0t4hy8	28	34	Bs	bs	NN
cord-011917-6u0t4hy8	28	35	,	,	,
cord-011917-6u0t4hy8	28	36	one	one	CD
cord-011917-6u0t4hy8	28	37	each	each	DT
cord-011917-6u0t4hy8	28	38	from	from	IN
cord-011917-6u0t4hy8	28	39	the	the	DT
cord-011917-6u0t4hy8	28	40	Yamagata	Yamagata	NNP
cord-011917-6u0t4hy8	28	41	and	and	CC
cord-011917-6u0t4hy8	28	42	Victoria	Victoria	NNP
cord-011917-6u0t4hy8	28	43	lineages	lineage	NNS
cord-011917-6u0t4hy8	28	44	.	.	.
cord-011917-6u0t4hy8	29	1	For	for	IN
cord-011917-6u0t4hy8	29	2	the	the	DT
cord-011917-6u0t4hy8	29	3	seasons	season	NNS
cord-011917-6u0t4hy8	29	4	between	between	IN
cord-011917-6u0t4hy8	29	5	2014	2014	CD
cord-011917-6u0t4hy8	29	6	and	and	CC
cord-011917-6u0t4hy8	29	7	2019	2019	CD
cord-011917-6u0t4hy8	29	8	,	,	,
cord-011917-6u0t4hy8	29	9	the	the	DT
cord-011917-6u0t4hy8	29	10	adjusted	adjusted	JJ
cord-011917-6u0t4hy8	29	11	overall	overall	JJ
cord-011917-6u0t4hy8	29	12	vaccine	vaccine	NN
cord-011917-6u0t4hy8	29	13	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	29	14	(	(	-LRB-
cord-011917-6u0t4hy8	29	15	VE	VE	NNP
cord-011917-6u0t4hy8	29	16	)	)	-RRB-
cord-011917-6u0t4hy8	29	17	in	in	IN
cord-011917-6u0t4hy8	29	18	the	the	DT
cord-011917-6u0t4hy8	29	19	United	United	NNP
cord-011917-6u0t4hy8	29	20	States	States	NNP
cord-011917-6u0t4hy8	29	21	ranged	range	VBD
cord-011917-6u0t4hy8	29	22	between	between	IN
cord-011917-6u0t4hy8	29	23	19	19	CD
cord-011917-6u0t4hy8	29	24	%	%	NN
cord-011917-6u0t4hy8	29	25	and	and	CC
cord-011917-6u0t4hy8	29	26	48	48	CD
cord-011917-6u0t4hy8	29	27	%	%	NN
cord-011917-6u0t4hy8	29	28	[	[	-LRB-
cord-011917-6u0t4hy8	29	29	28	28	CD
cord-011917-6u0t4hy8	29	30	]	]	-RRB-
cord-011917-6u0t4hy8	29	31	[	[	-LRB-
cord-011917-6u0t4hy8	29	32	29	29	CD
cord-011917-6u0t4hy8	29	33	]	]	-RRB-
cord-011917-6u0t4hy8	29	34	[	[	-LRB-
cord-011917-6u0t4hy8	29	35	30	30	CD
cord-011917-6u0t4hy8	29	36	]	]	-RRB-
cord-011917-6u0t4hy8	29	37	[	[	-LRB-
cord-011917-6u0t4hy8	29	38	31	31	CD
cord-011917-6u0t4hy8	29	39	]	]	-RRB-
cord-011917-6u0t4hy8	29	40	[	[	-LRB-
cord-011917-6u0t4hy8	29	41	32	32	CD
cord-011917-6u0t4hy8	29	42	]	]	-RRB-
cord-011917-6u0t4hy8	29	43	.	.	.
cord-011917-6u0t4hy8	30	1	The	the	DT
cord-011917-6u0t4hy8	30	2	VE	VE	NNP
cord-011917-6u0t4hy8	30	3	varies	vary	VBZ
cord-011917-6u0t4hy8	30	4	between	between	IN
cord-011917-6u0t4hy8	30	5	subtypes	subtype	NNS
cord-011917-6u0t4hy8	30	6	and	and	CC
cord-011917-6u0t4hy8	30	7	year	year	NN
cord-011917-6u0t4hy8	30	8	to	to	IN
cord-011917-6u0t4hy8	30	9	year	year	NN
cord-011917-6u0t4hy8	30	10	due	due	IN
cord-011917-6u0t4hy8	30	11	to	to	IN
cord-011917-6u0t4hy8	30	12	numerous	numerous	JJ
cord-011917-6u0t4hy8	30	13	viral	viral	JJ
cord-011917-6u0t4hy8	30	14	(	(	-LRB-
cord-011917-6u0t4hy8	30	15	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	30	16	drift	drift	NN
cord-011917-6u0t4hy8	30	17	/	/	SYM
cord-011917-6u0t4hy8	30	18	shift	shift	NN
cord-011917-6u0t4hy8	30	19	)	)	-RRB-
cord-011917-6u0t4hy8	30	20	,	,	,
cord-011917-6u0t4hy8	30	21	vaccine	vaccine	NN
cord-011917-6u0t4hy8	30	22	(	(	-LRB-
cord-011917-6u0t4hy8	30	23	egg	egg	NN
cord-011917-6u0t4hy8	30	24	-	-	HYPH
cord-011917-6u0t4hy8	30	25	adaptive	adaptive	JJ
cord-011917-6u0t4hy8	30	26	changes	change	NNS
cord-011917-6u0t4hy8	30	27	,	,	,
cord-011917-6u0t4hy8	30	28	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	30	29	)	)	-RRB-
cord-011917-6u0t4hy8	30	30	and	and	CC
cord-011917-6u0t4hy8	30	31	host	host	NN
cord-011917-6u0t4hy8	30	32	(	(	-LRB-
cord-011917-6u0t4hy8	30	33	age	age	NN
cord-011917-6u0t4hy8	30	34	,	,	,
cord-011917-6u0t4hy8	30	35	immune	immune	NN
cord-011917-6u0t4hy8	30	36	-	-	HYPH
cord-011917-6u0t4hy8	30	37	status	status	NN
cord-011917-6u0t4hy8	30	38	,	,	,
cord-011917-6u0t4hy8	30	39	pre	pre	JJ
cord-011917-6u0t4hy8	30	40	-	-	JJ
cord-011917-6u0t4hy8	30	41	immunity	immunity	JJ
cord-011917-6u0t4hy8	30	42	)	)	-RRB-
cord-011917-6u0t4hy8	30	43	factors	factor	NNS
cord-011917-6u0t4hy8	30	44	.	.	.
cord-011917-6u0t4hy8	31	1	To	to	TO
cord-011917-6u0t4hy8	31	2	address	address	VB
cord-011917-6u0t4hy8	31	3	the	the	DT
cord-011917-6u0t4hy8	31	4	viral	viral	JJ
cord-011917-6u0t4hy8	31	5	contributions	contribution	NNS
cord-011917-6u0t4hy8	31	6	,	,	,
cord-011917-6u0t4hy8	31	7	the	the	DT
cord-011917-6u0t4hy8	31	8	World	World	NNP
cord-011917-6u0t4hy8	31	9	Health	Health	NNP
cord-011917-6u0t4hy8	31	10	Organization	Organization	NNP
cord-011917-6u0t4hy8	31	11	(	(	-LRB-
cord-011917-6u0t4hy8	31	12	WHO	who	WP
cord-011917-6u0t4hy8	31	13	)	)	-RRB-
cord-011917-6u0t4hy8	31	14	reviews	review	VBZ
cord-011917-6u0t4hy8	31	15	data	datum	NNS
cord-011917-6u0t4hy8	31	16	from	from	IN
cord-011917-6u0t4hy8	31	17	its	-PRON-	PRP$
cord-011917-6u0t4hy8	31	18	global	global	JJ
cord-011917-6u0t4hy8	31	19	influenza	influenza	NN
cord-011917-6u0t4hy8	31	20	surveillance	surveillance	NN
cord-011917-6u0t4hy8	31	21	network	network	NN
cord-011917-6u0t4hy8	31	22	to	to	TO
cord-011917-6u0t4hy8	31	23	identify	identify	VB
cord-011917-6u0t4hy8	31	24	circulating	circulate	VBG
cord-011917-6u0t4hy8	31	25	strains	strain	NNS
cord-011917-6u0t4hy8	31	26	,	,	,
cord-011917-6u0t4hy8	31	27	heavily	heavily	RB
cord-011917-6u0t4hy8	31	28	weighting	weight	VBG
cord-011917-6u0t4hy8	31	29	ferret	ferret	NN
cord-011917-6u0t4hy8	31	30	serological	serological	JJ
cord-011917-6u0t4hy8	31	31	cross	cross	JJ
cord-011917-6u0t4hy8	31	32	-	-	JJ
cord-011917-6u0t4hy8	31	33	reactivity	reactivity	JJ
cord-011917-6u0t4hy8	31	34	data	datum	NNS
cord-011917-6u0t4hy8	31	35	to	to	TO
cord-011917-6u0t4hy8	31	36	determine	determine	VB
cord-011917-6u0t4hy8	31	37	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	31	38	drifts	drift	NNS
cord-011917-6u0t4hy8	31	39	.	.	.
cord-011917-6u0t4hy8	32	1	Vaccine	vaccine	NN
cord-011917-6u0t4hy8	32	2	manufacturers	manufacturer	NNS
cord-011917-6u0t4hy8	32	3	are	be	VBP
cord-011917-6u0t4hy8	32	4	then	then	RB
cord-011917-6u0t4hy8	32	5	provided	provide	VBN
cord-011917-6u0t4hy8	32	6	a	a	DT
cord-011917-6u0t4hy8	32	7	list	list	NN
cord-011917-6u0t4hy8	32	8	of	of	IN
cord-011917-6u0t4hy8	32	9	recommended	recommend	VBN
cord-011917-6u0t4hy8	32	10	vaccine	vaccine	NN
cord-011917-6u0t4hy8	32	11	strains	strain	NNS
cord-011917-6u0t4hy8	32	12	for	for	IN
cord-011917-6u0t4hy8	32	13	that	that	DT
cord-011917-6u0t4hy8	32	14	particular	particular	JJ
cord-011917-6u0t4hy8	32	15	season	season	NN
cord-011917-6u0t4hy8	32	16	for	for	IN
cord-011917-6u0t4hy8	32	17	either	either	CC
cord-011917-6u0t4hy8	32	18	the	the	DT
cord-011917-6u0t4hy8	32	19	Northern	northern	JJ
cord-011917-6u0t4hy8	32	20	or	or	CC
cord-011917-6u0t4hy8	32	21	Southern	southern	JJ
cord-011917-6u0t4hy8	32	22	hemisphere	hemisphere	NN
cord-011917-6u0t4hy8	32	23	.	.	.
cord-011917-6u0t4hy8	33	1	Methods	method	NNS
cord-011917-6u0t4hy8	33	2	to	to	TO
cord-011917-6u0t4hy8	33	3	increase	increase	VB
cord-011917-6u0t4hy8	33	4	the	the	DT
cord-011917-6u0t4hy8	33	5	host	host	NN
cord-011917-6u0t4hy8	33	6	response	response	NN
cord-011917-6u0t4hy8	33	7	to	to	IN
cord-011917-6u0t4hy8	33	8	vaccination	vaccination	NN
cord-011917-6u0t4hy8	33	9	and	and	CC
cord-011917-6u0t4hy8	33	10	VE	VE	NNP
cord-011917-6u0t4hy8	33	11	include	include	VBP
cord-011917-6u0t4hy8	33	12	different	different	JJ
cord-011917-6u0t4hy8	33	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	33	14	compositions	composition	NNS
cord-011917-6u0t4hy8	33	15	,	,	,
cord-011917-6u0t4hy8	33	16	especially	especially	RB
cord-011917-6u0t4hy8	33	17	in	in	IN
cord-011917-6u0t4hy8	33	18	adults	adult	NNS
cord-011917-6u0t4hy8	33	19	older	old	JJR
cord-011917-6u0t4hy8	33	20	than	than	IN
cord-011917-6u0t4hy8	33	21	65	65	CD
cord-011917-6u0t4hy8	33	22	years	year	NNS
cord-011917-6u0t4hy8	33	23	of	of	IN
cord-011917-6u0t4hy8	33	24	age	age	NN
cord-011917-6u0t4hy8	33	25	due	due	JJ
cord-011917-6u0t4hy8	33	26	to	to	IN
cord-011917-6u0t4hy8	33	27	their	-PRON-	PRP$
cord-011917-6u0t4hy8	33	28	decreased	decrease	VBN
cord-011917-6u0t4hy8	33	29	immune	immune	JJ
cord-011917-6u0t4hy8	33	30	response	response	NN
cord-011917-6u0t4hy8	33	31	to	to	IN
cord-011917-6u0t4hy8	33	32	vaccination	vaccination	NN
cord-011917-6u0t4hy8	33	33	[	[	-LRB-
cord-011917-6u0t4hy8	33	34	33	33	CD
cord-011917-6u0t4hy8	33	35	]	]	-RRB-
cord-011917-6u0t4hy8	33	36	.	.	.
cord-011917-6u0t4hy8	34	1	The	the	DT
cord-011917-6u0t4hy8	34	2	inclusion	inclusion	NN
cord-011917-6u0t4hy8	34	3	of	of	IN
cord-011917-6u0t4hy8	34	4	adjuvants	adjuvant	NNS
cord-011917-6u0t4hy8	34	5	,	,	,
cord-011917-6u0t4hy8	34	6	varying	vary	VBG
cord-011917-6u0t4hy8	34	7	the	the	DT
cord-011917-6u0t4hy8	34	8	amount	amount	NN
cord-011917-6u0t4hy8	34	9	of	of	IN
cord-011917-6u0t4hy8	34	10	antigen	antigen	NN
cord-011917-6u0t4hy8	34	11	,	,	,
cord-011917-6u0t4hy8	34	12	using	use	VBG
cord-011917-6u0t4hy8	34	13	live	live	RB
cord-011917-6u0t4hy8	34	14	-	-	HYPH
cord-011917-6u0t4hy8	34	15	attenuated	attenuate	VBN
cord-011917-6u0t4hy8	34	16	viral	viral	JJ
cord-011917-6u0t4hy8	34	17	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	34	18	and	and	CC
cord-011917-6u0t4hy8	34	19	varying	vary	VBG
cord-011917-6u0t4hy8	34	20	the	the	DT
cord-011917-6u0t4hy8	34	21	route	route	NN
cord-011917-6u0t4hy8	34	22	of	of	IN
cord-011917-6u0t4hy8	34	23	administration	administration	NN
cord-011917-6u0t4hy8	34	24	are	be	VBP
cord-011917-6u0t4hy8	34	25	all	all	DT
cord-011917-6u0t4hy8	34	26	methods	method	NNS
cord-011917-6u0t4hy8	34	27	used	use	VBN
cord-011917-6u0t4hy8	34	28	to	to	TO
cord-011917-6u0t4hy8	34	29	increase	increase	VB
cord-011917-6u0t4hy8	34	30	VE	VE	NNP
cord-011917-6u0t4hy8	34	31	.	.	.
cord-011917-6u0t4hy8	35	1	The	the	DT
cord-011917-6u0t4hy8	35	2	gold	gold	NN
cord-011917-6u0t4hy8	35	3	standard	standard	NN
cord-011917-6u0t4hy8	35	4	for	for	IN
cord-011917-6u0t4hy8	35	5	influenza	influenza	JJ
cord-011917-6u0t4hy8	35	6	vaccine	vaccine	NN
cord-011917-6u0t4hy8	35	7	research	research	NN
cord-011917-6u0t4hy8	35	8	is	be	VBZ
cord-011917-6u0t4hy8	35	9	the	the	DT
cord-011917-6u0t4hy8	35	10	ferret	ferret	NN
cord-011917-6u0t4hy8	35	11	animal	animal	NN
cord-011917-6u0t4hy8	35	12	model	model	NN
cord-011917-6u0t4hy8	35	13	[	[	-LRB-
cord-011917-6u0t4hy8	35	14	34	34	CD
cord-011917-6u0t4hy8	35	15	]	]	-RRB-
cord-011917-6u0t4hy8	35	16	.	.	.
cord-011917-6u0t4hy8	36	1	Currently	currently	RB
cord-011917-6u0t4hy8	36	2	,	,	,
cord-011917-6u0t4hy8	36	3	there	there	EX
cord-011917-6u0t4hy8	36	4	are	be	VBP
cord-011917-6u0t4hy8	36	5	models	model	NNS
cord-011917-6u0t4hy8	36	6	developed	develop	VBN
cord-011917-6u0t4hy8	36	7	that	that	DT
cord-011917-6u0t4hy8	36	8	capture	capture	NN
cord-011917-6u0t4hy8	36	9	infant	infant	NN
cord-011917-6u0t4hy8	36	10	[	[	-LRB-
cord-011917-6u0t4hy8	36	11	35	35	CD
cord-011917-6u0t4hy8	36	12	]	]	-RRB-
cord-011917-6u0t4hy8	36	13	,	,	,
cord-011917-6u0t4hy8	36	14	aged	age	VBN
cord-011917-6u0t4hy8	36	15	[	[	-LRB-
cord-011917-6u0t4hy8	36	16	36	36	CD
cord-011917-6u0t4hy8	36	17	]	]	-RRB-
cord-011917-6u0t4hy8	36	18	,	,	,
cord-011917-6u0t4hy8	36	19	naïve	naïve	JJ
cord-011917-6u0t4hy8	36	20	,	,	,
cord-011917-6u0t4hy8	36	21	and	and	CC
cord-011917-6u0t4hy8	36	22	pre	pre	JJ
cord-011917-6u0t4hy8	36	23	-	-	JJ
cord-011917-6u0t4hy8	36	24	immune	immune	JJ
cord-011917-6u0t4hy8	36	25	scenarios	scenario	NNS
cord-011917-6u0t4hy8	36	26	[	[	-LRB-
cord-011917-6u0t4hy8	36	27	37	37	CD
cord-011917-6u0t4hy8	36	28	]	]	-RRB-
cord-011917-6u0t4hy8	36	29	.	.	.
cord-011917-6u0t4hy8	37	1	During	during	IN
cord-011917-6u0t4hy8	37	2	vaccine	vaccine	NN
cord-011917-6u0t4hy8	37	3	selection	selection	NN
cord-011917-6u0t4hy8	37	4	,	,	,
cord-011917-6u0t4hy8	37	5	experts	expert	NNS
cord-011917-6u0t4hy8	37	6	consider	consider	VBP
cord-011917-6u0t4hy8	37	7	only	only	RB
cord-011917-6u0t4hy8	37	8	data	datum	NNS
cord-011917-6u0t4hy8	37	9	generated	generate	VBN
cord-011917-6u0t4hy8	37	10	from	from	IN
cord-011917-6u0t4hy8	37	11	the	the	DT
cord-011917-6u0t4hy8	37	12	naïve	naïve	JJ
cord-011917-6u0t4hy8	37	13	ferret	ferret	NN
cord-011917-6u0t4hy8	37	14	model	model	NN
cord-011917-6u0t4hy8	37	15	for	for	IN
cord-011917-6u0t4hy8	37	16	determination	determination	NN
cord-011917-6u0t4hy8	37	17	of	of	IN
cord-011917-6u0t4hy8	37	18	recommended	recommend	VBN
cord-011917-6u0t4hy8	37	19	strains	strain	NNS
cord-011917-6u0t4hy8	37	20	for	for	IN
cord-011917-6u0t4hy8	37	21	currently	currently	RB
cord-011917-6u0t4hy8	37	22	administered	administer	VBN
cord-011917-6u0t4hy8	37	23	human	human	JJ
cord-011917-6u0t4hy8	37	24	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	37	25	.	.	.
cord-011917-6u0t4hy8	38	1	However	however	RB
cord-011917-6u0t4hy8	38	2	,	,	,
cord-011917-6u0t4hy8	38	3	the	the	DT
cord-011917-6u0t4hy8	38	4	immune	immune	JJ
cord-011917-6u0t4hy8	38	5	response	response	NN
cord-011917-6u0t4hy8	38	6	in	in	IN
cord-011917-6u0t4hy8	38	7	a	a	DT
cord-011917-6u0t4hy8	38	8	naïve	naïve	JJ
cord-011917-6u0t4hy8	38	9	host	host	NN
cord-011917-6u0t4hy8	38	10	,	,	,
cord-011917-6u0t4hy8	38	11	compared	compare	VBN
cord-011917-6u0t4hy8	38	12	to	to	IN
cord-011917-6u0t4hy8	38	13	a	a	DT
cord-011917-6u0t4hy8	38	14	pre	pre	JJ
cord-011917-6u0t4hy8	38	15	-	-	JJ
cord-011917-6u0t4hy8	38	16	immune	immune	JJ
cord-011917-6u0t4hy8	38	17	individual	individual	NN
cord-011917-6u0t4hy8	38	18	,	,	,
cord-011917-6u0t4hy8	38	19	differs	differ	VBZ
cord-011917-6u0t4hy8	38	20	during	during	IN
cord-011917-6u0t4hy8	38	21	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	38	22	vaccination	vaccination	NN
cord-011917-6u0t4hy8	38	23	and/or	and/or	CC
cord-011917-6u0t4hy8	38	24	infection	infection	NN
cord-011917-6u0t4hy8	38	25	[	[	-LRB-
cord-011917-6u0t4hy8	38	26	38	38	CD
cord-011917-6u0t4hy8	38	27	,	,	,
cord-011917-6u0t4hy8	38	28	39	39	CD
cord-011917-6u0t4hy8	38	29	]	]	-RRB-
cord-011917-6u0t4hy8	38	30	.	.	.
cord-011917-6u0t4hy8	39	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	39	2	,	,	,
cord-011917-6u0t4hy8	39	3	the	the	DT
cord-011917-6u0t4hy8	39	4	use	use	NN
cord-011917-6u0t4hy8	39	5	of	of	IN
cord-011917-6u0t4hy8	39	6	naïve	naïve	JJ
cord-011917-6u0t4hy8	39	7	ferret	ferret	FW
cord-011917-6u0t4hy8	39	8	sera	sera	NNP
cord-011917-6u0t4hy8	39	9	for	for	IN
cord-011917-6u0t4hy8	39	10	vaccine	vaccine	NN
cord-011917-6u0t4hy8	39	11	strain	strain	NN
cord-011917-6u0t4hy8	39	12	selection	selection	NN
cord-011917-6u0t4hy8	39	13	is	be	VBZ
cord-011917-6u0t4hy8	39	14	potentially	potentially	RB
cord-011917-6u0t4hy8	39	15	misrepresentative	misrepresentative	JJ
cord-011917-6u0t4hy8	39	16	of	of	IN
cord-011917-6u0t4hy8	39	17	the	the	DT
cord-011917-6u0t4hy8	39	18	pre	pre	JJ
cord-011917-6u0t4hy8	39	19	-	-	JJ
cord-011917-6u0t4hy8	39	20	immune	immune	JJ
cord-011917-6u0t4hy8	39	21	human	human	JJ
cord-011917-6u0t4hy8	39	22	population	population	NN
cord-011917-6u0t4hy8	39	23	that	that	WDT
cord-011917-6u0t4hy8	39	24	receives	receive	VBZ
cord-011917-6u0t4hy8	39	25	each	each	DT
cord-011917-6u0t4hy8	39	26	season	season	NN
cord-011917-6u0t4hy8	39	27	's	's	POS
cord-011917-6u0t4hy8	39	28	influenza	influenza	NN
cord-011917-6u0t4hy8	39	29	virus	virus	NN
cord-011917-6u0t4hy8	39	30	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	39	31	,	,	,
cord-011917-6u0t4hy8	39	32	contributing	contribute	VBG
cord-011917-6u0t4hy8	39	33	to	to	IN
cord-011917-6u0t4hy8	39	34	the	the	DT
cord-011917-6u0t4hy8	39	35	observed	observed	JJ
cord-011917-6u0t4hy8	39	36	VE	VE	NNP
cord-011917-6u0t4hy8	39	37	.	.	.
cord-011917-6u0t4hy8	40	1	A	a	DT
cord-011917-6u0t4hy8	40	2	pre	pre	JJ
cord-011917-6u0t4hy8	40	3	-	-	JJ
cord-011917-6u0t4hy8	40	4	immune	immune	JJ
cord-011917-6u0t4hy8	40	5	animal	animal	NN
cord-011917-6u0t4hy8	40	6	model	model	NN
cord-011917-6u0t4hy8	40	7	should	should	MD
cord-011917-6u0t4hy8	40	8	be	be	VB
cord-011917-6u0t4hy8	40	9	established	establish	VBN
cord-011917-6u0t4hy8	40	10	through	through	IN
cord-011917-6u0t4hy8	40	11	an	an	DT
cord-011917-6u0t4hy8	40	12	initial	initial	JJ
cord-011917-6u0t4hy8	40	13	viral	viral	JJ
cord-011917-6u0t4hy8	40	14	infection	infection	NN
cord-011917-6u0t4hy8	40	15	,	,	,
cord-011917-6u0t4hy8	40	16	instead	instead	RB
cord-011917-6u0t4hy8	40	17	of	of	IN
cord-011917-6u0t4hy8	40	18	through	through	IN
cord-011917-6u0t4hy8	40	19	a	a	DT
cord-011917-6u0t4hy8	40	20	vaccination	vaccination	NN
cord-011917-6u0t4hy8	40	21	regimen	regimen	NN
cord-011917-6u0t4hy8	40	22	.	.	.
cord-011917-6u0t4hy8	41	1	Vaccination	vaccination	NN
cord-011917-6u0t4hy8	41	2	can	can	MD
cord-011917-6u0t4hy8	41	3	not	not	RB
cord-011917-6u0t4hy8	41	4	be	be	VB
cord-011917-6u0t4hy8	41	5	a	a	DT
cord-011917-6u0t4hy8	41	6	surrogate	surrogate	NN
cord-011917-6u0t4hy8	41	7	for	for	IN
cord-011917-6u0t4hy8	41	8	viral	viral	JJ
cord-011917-6u0t4hy8	41	9	imprinting	imprinting	NN
cord-011917-6u0t4hy8	41	10	and	and	CC
cord-011917-6u0t4hy8	41	11	pre	pre	JJ
cord-011917-6u0t4hy8	41	12	-	-	NN
cord-011917-6u0t4hy8	41	13	immunity	immunity	NN
cord-011917-6u0t4hy8	41	14	due	due	IN
cord-011917-6u0t4hy8	41	15	to	to	IN
cord-011917-6u0t4hy8	41	16	the	the	DT
cord-011917-6u0t4hy8	41	17	inequivalences	inequivalence	NNS
cord-011917-6u0t4hy8	41	18	in	in	IN
cord-011917-6u0t4hy8	41	19	the	the	DT
cord-011917-6u0t4hy8	41	20	immune	immune	JJ
cord-011917-6u0t4hy8	41	21	responses	response	NNS
cord-011917-6u0t4hy8	41	22	to	to	IN
cord-011917-6u0t4hy8	41	23	an	an	DT
cord-011917-6u0t4hy8	41	24	active	active	JJ
cord-011917-6u0t4hy8	41	25	influenza	influenza	NN
cord-011917-6u0t4hy8	41	26	infection	infection	NN
cord-011917-6u0t4hy8	41	27	versus	versus	IN
cord-011917-6u0t4hy8	41	28	an	an	DT
cord-011917-6u0t4hy8	41	29	intramuscular	intramuscular	JJ
cord-011917-6u0t4hy8	41	30	unadjuvanted	unadjuvanted	JJ
cord-011917-6u0t4hy8	41	31	vaccination	vaccination	NN
cord-011917-6u0t4hy8	41	32	[	[	-LRB-
cord-011917-6u0t4hy8	41	33	38	38	CD
cord-011917-6u0t4hy8	41	34	]	]	-RRB-
cord-011917-6u0t4hy8	41	35	.	.	.
cord-011917-6u0t4hy8	42	1	Administering	administer	VBG
cord-011917-6u0t4hy8	42	2	a	a	DT
cord-011917-6u0t4hy8	42	3	vaccine	vaccine	NN
cord-011917-6u0t4hy8	42	4	matched	match	VBN
cord-011917-6u0t4hy8	42	5	to	to	IN
cord-011917-6u0t4hy8	42	6	the	the	DT
cord-011917-6u0t4hy8	42	7	challenge	challenge	NN
cord-011917-6u0t4hy8	42	8	virus	virus	NN
cord-011917-6u0t4hy8	42	9	does	do	VBZ
cord-011917-6u0t4hy8	42	10	not	not	RB
cord-011917-6u0t4hy8	42	11	produce	produce	VB
cord-011917-6u0t4hy8	42	12	a	a	DT
cord-011917-6u0t4hy8	42	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	42	14	with	with	IN
cord-011917-6u0t4hy8	42	15	100	100	CD
cord-011917-6u0t4hy8	42	16	%	%	NN
cord-011917-6u0t4hy8	42	17	efficacy	efficacy	NN
cord-011917-6u0t4hy8	42	18	.	.	.
cord-011917-6u0t4hy8	43	1	Healthy	healthy	JJ
cord-011917-6u0t4hy8	43	2	volunteers	volunteer	NNS
cord-011917-6u0t4hy8	43	3	vaccinated	vaccinate	VBN
cord-011917-6u0t4hy8	43	4	with	with	IN
cord-011917-6u0t4hy8	43	5	inactivated	inactivated	JJ
cord-011917-6u0t4hy8	43	6	or	or	CC
cord-011917-6u0t4hy8	43	7	cold	cold	RB
cord-011917-6u0t4hy8	43	8	-	-	HYPH
cord-011917-6u0t4hy8	43	9	adapted	adapt	VBN
cord-011917-6u0t4hy8	43	10	live	live	JJ
cord-011917-6u0t4hy8	43	11	influenza	influenza	NN
cord-011917-6u0t4hy8	43	12	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	43	13	were	be	VBD
cord-011917-6u0t4hy8	43	14	not	not	RB
cord-011917-6u0t4hy8	43	15	all	all	DT
cord-011917-6u0t4hy8	43	16	protected	protect	VBN
cord-011917-6u0t4hy8	43	17	from	from	IN
cord-011917-6u0t4hy8	43	18	challenge	challenge	NN
cord-011917-6u0t4hy8	43	19	with	with	IN
cord-011917-6u0t4hy8	43	20	homologous	homologous	JJ
cord-011917-6u0t4hy8	43	21	viruses	virus	NNS
cord-011917-6u0t4hy8	43	22	;	;	:
cord-011917-6u0t4hy8	43	23	the	the	DT
cord-011917-6u0t4hy8	43	24	estimated	estimate	VBN
cord-011917-6u0t4hy8	43	25	protective	protective	JJ
cord-011917-6u0t4hy8	43	26	efficacies	efficacy	NNS
cord-011917-6u0t4hy8	43	27	were	be	VBD
cord-011917-6u0t4hy8	43	28	71	71	CD
cord-011917-6u0t4hy8	43	29	%	%	NN
cord-011917-6u0t4hy8	43	30	and	and	CC
cord-011917-6u0t4hy8	43	31	85	85	CD
cord-011917-6u0t4hy8	43	32	%	%	NN
cord-011917-6u0t4hy8	43	33	,	,	,
cord-011917-6u0t4hy8	43	34	respectively	respectively	RB
cord-011917-6u0t4hy8	43	35	[	[	-LRB-
cord-011917-6u0t4hy8	43	36	40	40	CD
cord-011917-6u0t4hy8	43	37	]	]	-RRB-
cord-011917-6u0t4hy8	43	38	.	.	.
cord-011917-6u0t4hy8	44	1	Vaccination	vaccination	NN
cord-011917-6u0t4hy8	44	2	does	do	VBZ
cord-011917-6u0t4hy8	44	3	not	not	RB
cord-011917-6u0t4hy8	44	4	induce	induce	VB
cord-011917-6u0t4hy8	44	5	a	a	DT
cord-011917-6u0t4hy8	44	6	robust	robust	JJ
cord-011917-6u0t4hy8	44	7	T	t	NN
cord-011917-6u0t4hy8	44	8	-	-	HYPH
cord-011917-6u0t4hy8	44	9	cell	cell	NN
cord-011917-6u0t4hy8	44	10	response	response	NN
cord-011917-6u0t4hy8	44	11	compared	compare	VBN
cord-011917-6u0t4hy8	44	12	to	to	IN
cord-011917-6u0t4hy8	44	13	infection	infection	NN
cord-011917-6u0t4hy8	44	14	,	,	,
cord-011917-6u0t4hy8	44	15	which	which	WDT
cord-011917-6u0t4hy8	44	16	,	,	,
cord-011917-6u0t4hy8	44	17	in	in	IN
cord-011917-6u0t4hy8	44	18	ferrets	ferret	NNS
cord-011917-6u0t4hy8	44	19	,	,	,
cord-011917-6u0t4hy8	44	20	has	have	VBZ
cord-011917-6u0t4hy8	44	21	been	be	VBN
cord-011917-6u0t4hy8	44	22	found	find	VBN
cord-011917-6u0t4hy8	44	23	to	to	TO
cord-011917-6u0t4hy8	44	24	contribute	contribute	VB
cord-011917-6u0t4hy8	44	25	to	to	IN
cord-011917-6u0t4hy8	44	26	sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	44	27	immunity	immunity	NN
cord-011917-6u0t4hy8	44	28	[	[	-LRB-
cord-011917-6u0t4hy8	44	29	41	41	CD
cord-011917-6u0t4hy8	44	30	]	]	-RRB-
cord-011917-6u0t4hy8	44	31	.	.	.
cord-011917-6u0t4hy8	45	1	Furthermore	furthermore	RB
cord-011917-6u0t4hy8	45	2	in	in	IN
cord-011917-6u0t4hy8	45	3	ferrets	ferret	NNS
cord-011917-6u0t4hy8	45	4	,	,	,
cord-011917-6u0t4hy8	45	5	vaccination	vaccination	NN
cord-011917-6u0t4hy8	45	6	and	and	CC
cord-011917-6u0t4hy8	45	7	viral	viral	JJ
cord-011917-6u0t4hy8	45	8	pre	pre	JJ
cord-011917-6u0t4hy8	45	9	-	-	NN
cord-011917-6u0t4hy8	45	10	immunity	immunity	JJ
cord-011917-6u0t4hy8	45	11	differ	differ	NNS
cord-011917-6u0t4hy8	45	12	in	in	IN
cord-011917-6u0t4hy8	45	13	their	-PRON-	PRP$
cord-011917-6u0t4hy8	45	14	protective	protective	JJ
cord-011917-6u0t4hy8	45	15	outcomes	outcome	NNS
cord-011917-6u0t4hy8	45	16	as	as	RB
cord-011917-6u0t4hy8	45	17	well	well	RB
cord-011917-6u0t4hy8	45	18	[	[	-LRB-
cord-011917-6u0t4hy8	45	19	41	41	CD
cord-011917-6u0t4hy8	45	20	]	]	-RRB-
cord-011917-6u0t4hy8	45	21	.	.	.
cord-011917-6u0t4hy8	46	1	Significant	significant	JJ
cord-011917-6u0t4hy8	46	2	immunological	immunological	JJ
cord-011917-6u0t4hy8	46	3	differences	difference	NNS
cord-011917-6u0t4hy8	46	4	,	,	,
cord-011917-6u0t4hy8	46	5	such	such	JJ
cord-011917-6u0t4hy8	46	6	as	as	IN
cord-011917-6u0t4hy8	46	7	ratios	ratio	NNS
cord-011917-6u0t4hy8	46	8	of	of	IN
cord-011917-6u0t4hy8	46	9	IgG	IgG	NNP
cord-011917-6u0t4hy8	46	10	and	and	CC
cord-011917-6u0t4hy8	46	11	IgA	IgA	NNP
cord-011917-6u0t4hy8	46	12	influenza	influenza	NN
cord-011917-6u0t4hy8	46	13	-	-	HYPH
cord-011917-6u0t4hy8	46	14	specific	specific	JJ
cord-011917-6u0t4hy8	46	15	antibodies	antibody	NNS
cord-011917-6u0t4hy8	46	16	and	and	CC
cord-011917-6u0t4hy8	46	17	targeted	target	VBN
cord-011917-6u0t4hy8	46	18	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	46	19	sites	site	NNS
cord-011917-6u0t4hy8	46	20	[	[	-LRB-
cord-011917-6u0t4hy8	46	21	26	26	CD
cord-011917-6u0t4hy8	46	22	]	]	-RRB-
cord-011917-6u0t4hy8	46	23	,	,	,
cord-011917-6u0t4hy8	46	24	can	can	MD
cord-011917-6u0t4hy8	46	25	not	not	RB
cord-011917-6u0t4hy8	46	26	be	be	VB
cord-011917-6u0t4hy8	46	27	discerned	discern	VBN
cord-011917-6u0t4hy8	46	28	and	and	CC
cord-011917-6u0t4hy8	46	29	identified	identify	VBN
cord-011917-6u0t4hy8	46	30	with	with	IN
cord-011917-6u0t4hy8	46	31	the	the	DT
cord-011917-6u0t4hy8	46	32	commonly	commonly	RB
cord-011917-6u0t4hy8	46	33	used	use	VBN
cord-011917-6u0t4hy8	46	34	hemagglutinin	hemagglutinin	NN
cord-011917-6u0t4hy8	46	35	inhibition	inhibition	NN
cord-011917-6u0t4hy8	46	36	assay	assay	NN
cord-011917-6u0t4hy8	46	37	(	(	-LRB-
cord-011917-6u0t4hy8	46	38	HAI	HAI	NNP
cord-011917-6u0t4hy8	46	39	)	)	-RRB-
cord-011917-6u0t4hy8	46	40	.	.	.
cord-011917-6u0t4hy8	47	1	A	a	DT
cord-011917-6u0t4hy8	47	2	pre	pre	JJ
cord-011917-6u0t4hy8	47	3	-	-	JJ
cord-011917-6u0t4hy8	47	4	immune	immune	JJ
cord-011917-6u0t4hy8	47	5	-	-	HYPH
cord-011917-6u0t4hy8	47	6	vaccination	vaccination	NN
cord-011917-6u0t4hy8	47	7	ferret	ferret	NN
cord-011917-6u0t4hy8	47	8	model	model	NN
cord-011917-6u0t4hy8	47	9	was	be	VBD
cord-011917-6u0t4hy8	47	10	used	use	VBN
cord-011917-6u0t4hy8	47	11	to	to	TO
cord-011917-6u0t4hy8	47	12	investigate	investigate	VB
cord-011917-6u0t4hy8	47	13	the	the	DT
cord-011917-6u0t4hy8	47	14	phenomenon	phenomenon	NN
cord-011917-6u0t4hy8	47	15	of	of	IN
cord-011917-6u0t4hy8	47	16	low	low	JJ
cord-011917-6u0t4hy8	47	17	efficacy	efficacy	NN
cord-011917-6u0t4hy8	47	18	from	from	IN
cord-011917-6u0t4hy8	47	19	repeat	repeat	NN
cord-011917-6u0t4hy8	47	20	vaccination	vaccination	NN
cord-011917-6u0t4hy8	47	21	with	with	IN
cord-011917-6u0t4hy8	47	22	commercial	commercial	JJ
cord-011917-6u0t4hy8	47	23	quadrivalent	quadrivalent	NN
cord-011917-6u0t4hy8	47	24	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	47	25	influenza	influenza	NN
cord-011917-6u0t4hy8	47	26	vaccine	vaccine	NN
cord-011917-6u0t4hy8	47	27	that	that	WDT
cord-011917-6u0t4hy8	47	28	occurs	occur	VBZ
cord-011917-6u0t4hy8	47	29	in	in	IN
cord-011917-6u0t4hy8	47	30	humans	human	NNS
cord-011917-6u0t4hy8	47	31	[	[	-LRB-
cord-011917-6u0t4hy8	47	32	42	42	CD
cord-011917-6u0t4hy8	47	33	]	]	-RRB-
cord-011917-6u0t4hy8	47	34	.	.	.
cord-011917-6u0t4hy8	48	1	When	when	WRB
cord-011917-6u0t4hy8	48	2	matched	match	VBN
cord-011917-6u0t4hy8	48	3	to	to	IN
cord-011917-6u0t4hy8	48	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	48	5	vaccinated	vaccinate	VBN
cord-011917-6u0t4hy8	48	6	once	once	RB
cord-011917-6u0t4hy8	48	7	,	,	,
cord-011917-6u0t4hy8	48	8	repeatedly	repeatedly	RB
cord-011917-6u0t4hy8	48	9	vaccinated	vaccinate	VBD
cord-011917-6u0t4hy8	48	10	ferrets	ferret	NNS
cord-011917-6u0t4hy8	48	11	had	have	VBD
cord-011917-6u0t4hy8	48	12	less	less	JJR
cord-011917-6u0t4hy8	48	13	protection	protection	NN
cord-011917-6u0t4hy8	48	14	,	,	,
cord-011917-6u0t4hy8	48	15	higher	high	JJR
cord-011917-6u0t4hy8	48	16	viral	viral	JJ
cord-011917-6u0t4hy8	48	17	shedding	shedding	NN
cord-011917-6u0t4hy8	48	18	and	and	CC
cord-011917-6u0t4hy8	48	19	lower	low	JJR
cord-011917-6u0t4hy8	48	20	T	t	NN
cord-011917-6u0t4hy8	48	21	-	-	HYPH
cord-011917-6u0t4hy8	48	22	lymphocyte	lymphocyte	NN
cord-011917-6u0t4hy8	48	23	counts	count	NNS
cord-011917-6u0t4hy8	48	24	,	,	,
cord-011917-6u0t4hy8	48	25	whereas	whereas	IN
cord-011917-6u0t4hy8	48	26	the	the	DT
cord-011917-6u0t4hy8	48	27	serological	serological	JJ
cord-011917-6u0t4hy8	48	28	responses	response	NNS
cord-011917-6u0t4hy8	48	29	,	,	,
cord-011917-6u0t4hy8	48	30	cell	cell	NN
cord-011917-6u0t4hy8	48	31	-	-	HYPH
cord-011917-6u0t4hy8	48	32	mediated	mediate	VBN
cord-011917-6u0t4hy8	48	33	immunity	immunity	NN
cord-011917-6u0t4hy8	48	34	,	,	,
cord-011917-6u0t4hy8	48	35	and	and	CC
cord-011917-6u0t4hy8	48	36	histopathological	histopathological	JJ
cord-011917-6u0t4hy8	48	37	changes	change	NNS
cord-011917-6u0t4hy8	48	38	did	do	VBD
cord-011917-6u0t4hy8	48	39	not	not	RB
cord-011917-6u0t4hy8	48	40	differ	differ	VB
cord-011917-6u0t4hy8	48	41	.	.	.
cord-011917-6u0t4hy8	49	1	It	-PRON-	PRP
cord-011917-6u0t4hy8	49	2	was	be	VBD
cord-011917-6u0t4hy8	49	3	hypothesized	hypothesize	VBN
cord-011917-6u0t4hy8	49	4	that	that	IN
cord-011917-6u0t4hy8	49	5	although	although	IN
cord-011917-6u0t4hy8	49	6	the	the	DT
cord-011917-6u0t4hy8	49	7	magnitude	magnitude	NN
cord-011917-6u0t4hy8	49	8	of	of	IN
cord-011917-6u0t4hy8	49	9	the	the	DT
cord-011917-6u0t4hy8	49	10	serological	serological	JJ
cord-011917-6u0t4hy8	49	11	response	response	NN
cord-011917-6u0t4hy8	49	12	was	be	VBD
cord-011917-6u0t4hy8	49	13	similar	similar	JJ
cord-011917-6u0t4hy8	49	14	the	the	DT
cord-011917-6u0t4hy8	49	15	composition	composition	NN
cord-011917-6u0t4hy8	49	16	differed	differ	VBD
cord-011917-6u0t4hy8	49	17	,	,	,
cord-011917-6u0t4hy8	49	18	resulting	result	VBG
cord-011917-6u0t4hy8	49	19	in	in	IN
cord-011917-6u0t4hy8	49	20	the	the	DT
cord-011917-6u0t4hy8	49	21	difference	difference	NN
cord-011917-6u0t4hy8	49	22	of	of	IN
cord-011917-6u0t4hy8	49	23	protection	protection	NN
cord-011917-6u0t4hy8	49	24	.	.	.
cord-011917-6u0t4hy8	50	1	A	a	DT
cord-011917-6u0t4hy8	50	2	larger	large	JJR
cord-011917-6u0t4hy8	50	3	ratio	ratio	NN
cord-011917-6u0t4hy8	50	4	of	of	IN
cord-011917-6u0t4hy8	50	5	non	non	JJ
cord-011917-6u0t4hy8	50	6	-	-	JJ
cord-011917-6u0t4hy8	50	7	neutralizing	neutralizing	JJ
cord-011917-6u0t4hy8	50	8	to	to	IN
cord-011917-6u0t4hy8	50	9	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	50	10	antibodies	antibody	NNS
cord-011917-6u0t4hy8	50	11	may	may	MD
cord-011917-6u0t4hy8	50	12	have	have	VB
cord-011917-6u0t4hy8	50	13	been	be	VBN
cord-011917-6u0t4hy8	50	14	recalled	recall	VBN
cord-011917-6u0t4hy8	50	15	in	in	IN
cord-011917-6u0t4hy8	50	16	the	the	DT
cord-011917-6u0t4hy8	50	17	repeat	repeat	NN
cord-011917-6u0t4hy8	50	18	vaccination	vaccination	NN
cord-011917-6u0t4hy8	50	19	group	group	NN
cord-011917-6u0t4hy8	50	20	.	.	.
cord-011917-6u0t4hy8	51	1	Hence	hence	RB
cord-011917-6u0t4hy8	51	2	,	,	,
cord-011917-6u0t4hy8	51	3	the	the	DT
cord-011917-6u0t4hy8	51	4	repeat	repeat	NN
cord-011917-6u0t4hy8	51	5	vaccination	vaccination	NN
cord-011917-6u0t4hy8	51	6	group	group	NN
cord-011917-6u0t4hy8	51	7	had	have	VBD
cord-011917-6u0t4hy8	51	8	lower	low	JJR
cord-011917-6u0t4hy8	51	9	vaccine	vaccine	NN
cord-011917-6u0t4hy8	51	10	efficacy	efficacy	NN
cord-011917-6u0t4hy8	51	11	compared	compare	VBN
cord-011917-6u0t4hy8	51	12	to	to	IN
cord-011917-6u0t4hy8	51	13	one	one	CD
cord-011917-6u0t4hy8	51	14	vaccination	vaccination	NN
cord-011917-6u0t4hy8	51	15	.	.	.
cord-011917-6u0t4hy8	52	1	Encouragingly	encouragingly	RB
cord-011917-6u0t4hy8	52	2	,	,	,
cord-011917-6u0t4hy8	52	3	the	the	DT
cord-011917-6u0t4hy8	52	4	repeat	repeat	NN
cord-011917-6u0t4hy8	52	5	vaccination	vaccination	NN
cord-011917-6u0t4hy8	52	6	group	group	NN
cord-011917-6u0t4hy8	52	7	was	be	VBD
cord-011917-6u0t4hy8	52	8	still	still	RB
cord-011917-6u0t4hy8	52	9	better	well	RBR
cord-011917-6u0t4hy8	52	10	protected	protect	VBN
cord-011917-6u0t4hy8	52	11	than	than	IN
cord-011917-6u0t4hy8	52	12	no	no	DT
cord-011917-6u0t4hy8	52	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	52	14	group	group	NN
cord-011917-6u0t4hy8	52	15	.	.	.
cord-011917-6u0t4hy8	53	1	The	the	DT
cord-011917-6u0t4hy8	53	2	relevance	relevance	NN
cord-011917-6u0t4hy8	53	3	of	of	IN
cord-011917-6u0t4hy8	53	4	using	use	VBG
cord-011917-6u0t4hy8	53	5	these	these	DT
cord-011917-6u0t4hy8	53	6	results	result	NNS
cord-011917-6u0t4hy8	53	7	to	to	TO
cord-011917-6u0t4hy8	53	8	explain	explain	VB
cord-011917-6u0t4hy8	53	9	the	the	DT
cord-011917-6u0t4hy8	53	10	decreased	decreased	JJ
cord-011917-6u0t4hy8	53	11	vaccine	vaccine	NN
cord-011917-6u0t4hy8	53	12	efficacy	efficacy	NN
cord-011917-6u0t4hy8	53	13	in	in	IN
cord-011917-6u0t4hy8	53	14	humans	human	NNS
cord-011917-6u0t4hy8	53	15	is	be	VBZ
cord-011917-6u0t4hy8	53	16	limited	limit	VBN
cord-011917-6u0t4hy8	53	17	due	due	IN
cord-011917-6u0t4hy8	53	18	to	to	IN
cord-011917-6u0t4hy8	53	19	the	the	DT
cord-011917-6u0t4hy8	53	20	lack	lack	NN
cord-011917-6u0t4hy8	53	21	of	of	IN
cord-011917-6u0t4hy8	53	22	pre	pre	JJ
cord-011917-6u0t4hy8	53	23	-	-	JJ
cord-011917-6u0t4hy8	53	24	immunity	immunity	JJ
cord-011917-6u0t4hy8	53	25	establishment	establishment	NN
cord-011917-6u0t4hy8	53	26	in	in	IN
cord-011917-6u0t4hy8	53	27	ferrets	ferret	NNS
cord-011917-6u0t4hy8	53	28	.	.	.
cord-011917-6u0t4hy8	54	1	Even	even	RB
cord-011917-6u0t4hy8	54	2	with	with	IN
cord-011917-6u0t4hy8	54	3	well	well	RB
cord-011917-6u0t4hy8	54	4	-	-	HYPH
cord-011917-6u0t4hy8	54	5	planned	plan	VBN
cord-011917-6u0t4hy8	54	6	studies	study	NNS
cord-011917-6u0t4hy8	54	7	,	,	,
cord-011917-6u0t4hy8	54	8	not	not	RB
cord-011917-6u0t4hy8	54	9	establishing	establish	VBG
cord-011917-6u0t4hy8	54	10	pre	pre	JJ
cord-011917-6u0t4hy8	54	11	-	-	NN
cord-011917-6u0t4hy8	54	12	immunity	immunity	NN
cord-011917-6u0t4hy8	54	13	creates	create	VBZ
cord-011917-6u0t4hy8	54	14	a	a	DT
cord-011917-6u0t4hy8	54	15	confounding	confounding	JJ
cord-011917-6u0t4hy8	54	16	factor	factor	NN
cord-011917-6u0t4hy8	54	17	when	when	WRB
cord-011917-6u0t4hy8	54	18	extrapolating	extrapolate	VBG
cord-011917-6u0t4hy8	54	19	the	the	DT
cord-011917-6u0t4hy8	54	20	findings	finding	NNS
cord-011917-6u0t4hy8	54	21	to	to	IN
cord-011917-6u0t4hy8	54	22	the	the	DT
cord-011917-6u0t4hy8	54	23	human	human	JJ
cord-011917-6u0t4hy8	54	24	population	population	NN
cord-011917-6u0t4hy8	54	25	.	.	.
cord-011917-6u0t4hy8	55	1	In	in	IN
cord-011917-6u0t4hy8	55	2	early	early	JJ
cord-011917-6u0t4hy8	55	3	ferret	ferret	JJ
cord-011917-6u0t4hy8	55	4	vaccination	vaccination	NN
cord-011917-6u0t4hy8	55	5	studies	study	NNS
cord-011917-6u0t4hy8	55	6	,	,	,
cord-011917-6u0t4hy8	55	7	the	the	DT
cord-011917-6u0t4hy8	55	8	administration	administration	NN
cord-011917-6u0t4hy8	55	9	of	of	IN
cord-011917-6u0t4hy8	55	10	unadjuvanted	unadjuvante	VBN
cord-011917-6u0t4hy8	55	11	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	55	12	elicited	elicit	VBD
cord-011917-6u0t4hy8	55	13	no	no	DT
cord-011917-6u0t4hy8	55	14	measurable	measurable	JJ
cord-011917-6u0t4hy8	55	15	antibody	antibody	NN
cord-011917-6u0t4hy8	55	16	outcome	outcome	NN
cord-011917-6u0t4hy8	55	17	.	.	.
cord-011917-6u0t4hy8	56	1	Not	not	RB
cord-011917-6u0t4hy8	56	2	all	all	DT
cord-011917-6u0t4hy8	56	3	naïve	naïve	JJ
cord-011917-6u0t4hy8	56	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	56	5	seroconvert	seroconvert	VBP
cord-011917-6u0t4hy8	56	6	to	to	IN
cord-011917-6u0t4hy8	56	7	influenza	influenza	NN
cord-011917-6u0t4hy8	56	8	vaccination	vaccination	NN
cord-011917-6u0t4hy8	56	9	[	[	-LRB-
cord-011917-6u0t4hy8	56	10	39	39	CD
cord-011917-6u0t4hy8	56	11	,	,	,
cord-011917-6u0t4hy8	56	12	[	[	-LRB-
cord-011917-6u0t4hy8	56	13	43	43	CD
cord-011917-6u0t4hy8	56	14	]	]	-RRB-
cord-011917-6u0t4hy8	56	15	[	[	-LRB-
cord-011917-6u0t4hy8	56	16	44	44	CD
cord-011917-6u0t4hy8	56	17	]	]	-RRB-
cord-011917-6u0t4hy8	56	18	[	[	-LRB-
cord-011917-6u0t4hy8	56	19	45	45	CD
cord-011917-6u0t4hy8	56	20	]	]	-RRB-
cord-011917-6u0t4hy8	56	21	.	.	.
cord-011917-6u0t4hy8	57	1	Even	even	RB
cord-011917-6u0t4hy8	57	2	with	with	IN
cord-011917-6u0t4hy8	57	3	the	the	DT
cord-011917-6u0t4hy8	57	4	addition	addition	NN
cord-011917-6u0t4hy8	57	5	of	of	IN
cord-011917-6u0t4hy8	57	6	an	an	DT
cord-011917-6u0t4hy8	57	7	adjuvant	adjuvant	NN
cord-011917-6u0t4hy8	57	8	,	,	,
cord-011917-6u0t4hy8	57	9	the	the	DT
cord-011917-6u0t4hy8	57	10	immune	immune	JJ
cord-011917-6u0t4hy8	57	11	response	response	NN
cord-011917-6u0t4hy8	57	12	can	can	MD
cord-011917-6u0t4hy8	57	13	be	be	VB
cord-011917-6u0t4hy8	57	14	weak	weak	JJ
cord-011917-6u0t4hy8	57	15	,	,	,
cord-011917-6u0t4hy8	57	16	especially	especially	RB
cord-011917-6u0t4hy8	57	17	when	when	WRB
cord-011917-6u0t4hy8	57	18	compared	compare	VBN
cord-011917-6u0t4hy8	57	19	to	to	IN
cord-011917-6u0t4hy8	57	20	the	the	DT
cord-011917-6u0t4hy8	57	21	immune	immune	JJ
cord-011917-6u0t4hy8	57	22	response	response	NN
cord-011917-6u0t4hy8	57	23	elicited	elicit	VBN
cord-011917-6u0t4hy8	57	24	by	by	IN
cord-011917-6u0t4hy8	57	25	a	a	DT
cord-011917-6u0t4hy8	57	26	live	live	JJ
cord-011917-6u0t4hy8	57	27	homologous	homologous	JJ
cord-011917-6u0t4hy8	57	28	infection	infection	NN
cord-011917-6u0t4hy8	57	29	[	[	-LRB-
cord-011917-6u0t4hy8	57	30	45	45	CD
cord-011917-6u0t4hy8	57	31	,	,	,
cord-011917-6u0t4hy8	57	32	46	46	CD
cord-011917-6u0t4hy8	57	33	]	]	-RRB-
cord-011917-6u0t4hy8	57	34	.	.	.
cord-011917-6u0t4hy8	58	1	The	the	DT
cord-011917-6u0t4hy8	58	2	lack	lack	NN
cord-011917-6u0t4hy8	58	3	of	of	IN
cord-011917-6u0t4hy8	58	4	an	an	DT
cord-011917-6u0t4hy8	58	5	antibody	antibody	NN
cord-011917-6u0t4hy8	58	6	response	response	NN
cord-011917-6u0t4hy8	58	7	is	be	VBZ
cord-011917-6u0t4hy8	58	8	associated	associate	VBN
cord-011917-6u0t4hy8	58	9	with	with	IN
cord-011917-6u0t4hy8	58	10	a	a	DT
cord-011917-6u0t4hy8	58	11	lack	lack	NN
cord-011917-6u0t4hy8	58	12	of	of	IN
cord-011917-6u0t4hy8	58	13	protection	protection	NN
cord-011917-6u0t4hy8	58	14	[	[	-LRB-
cord-011917-6u0t4hy8	58	15	47	47	CD
cord-011917-6u0t4hy8	58	16	]	]	-RRB-
cord-011917-6u0t4hy8	58	17	.	.	.
cord-011917-6u0t4hy8	59	1	For	for	IN
cord-011917-6u0t4hy8	59	2	instance	instance	NN
cord-011917-6u0t4hy8	59	3	,	,	,
cord-011917-6u0t4hy8	59	4	naïve	naïve	JJ
cord-011917-6u0t4hy8	59	5	ferrets	ferret	NNS
cord-011917-6u0t4hy8	59	6	immunized	immunize	VBN
cord-011917-6u0t4hy8	59	7	with	with	IN
cord-011917-6u0t4hy8	59	8	A(H3N2)/Hong	A(H3N2)/Hong	NNP
cord-011917-6u0t4hy8	59	9	Kong	Kong	NNP
cord-011917-6u0t4hy8	59	10	/	/	SYM
cord-011917-6u0t4hy8	59	11	X31/1968	X31/1968	NNP
cord-011917-6u0t4hy8	59	12	vaccine	vaccine	NN
cord-011917-6u0t4hy8	59	13	were	be	VBD
cord-011917-6u0t4hy8	59	14	all	all	DT
cord-011917-6u0t4hy8	59	15	susceptible	susceptible	JJ
cord-011917-6u0t4hy8	59	16	to	to	IN
cord-011917-6u0t4hy8	59	17	homologous	homologous	JJ
cord-011917-6u0t4hy8	59	18	challenge	challenge	NN
cord-011917-6u0t4hy8	59	19	and	and	CC
cord-011917-6u0t4hy8	59	20	none	none	NN
cord-011917-6u0t4hy8	59	21	produced	produce	VBD
cord-011917-6u0t4hy8	59	22	vaccine	vaccine	NN
cord-011917-6u0t4hy8	59	23	-	-	HYPH
cord-011917-6u0t4hy8	59	24	specific	specific	JJ
cord-011917-6u0t4hy8	59	25	serum	serum	NN
cord-011917-6u0t4hy8	59	26	HAI	HAI	NNP
cord-011917-6u0t4hy8	59	27	antibodies	antibody	NNS
cord-011917-6u0t4hy8	59	28	[	[	-LRB-
cord-011917-6u0t4hy8	59	29	39	39	CD
cord-011917-6u0t4hy8	59	30	]	]	-RRB-
cord-011917-6u0t4hy8	59	31	.	.	.
cord-011917-6u0t4hy8	60	1	This	this	DT
cord-011917-6u0t4hy8	60	2	low	low	JJ
cord-011917-6u0t4hy8	60	3	reactivity	reactivity	NN
cord-011917-6u0t4hy8	60	4	to	to	IN
cord-011917-6u0t4hy8	60	5	the	the	DT
cord-011917-6u0t4hy8	60	6	vaccine	vaccine	NN
cord-011917-6u0t4hy8	60	7	may	may	MD
cord-011917-6u0t4hy8	60	8	be	be	VB
cord-011917-6u0t4hy8	60	9	attributed	attribute	VBN
cord-011917-6u0t4hy8	60	10	to	to	IN
cord-011917-6u0t4hy8	60	11	the	the	DT
cord-011917-6u0t4hy8	60	12	outbred	outbred	JJ
cord-011917-6u0t4hy8	60	13	nature	nature	NN
cord-011917-6u0t4hy8	60	14	of	of	IN
cord-011917-6u0t4hy8	60	15	the	the	DT
cord-011917-6u0t4hy8	60	16	animal	animal	NN
cord-011917-6u0t4hy8	60	17	model	model	NN
cord-011917-6u0t4hy8	60	18	[	[	-LRB-
cord-011917-6u0t4hy8	60	19	42	42	CD
cord-011917-6u0t4hy8	60	20	]	]	-RRB-
cord-011917-6u0t4hy8	60	21	.	.	.
cord-011917-6u0t4hy8	61	1	Low	low	JJ
cord-011917-6u0t4hy8	61	2	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	61	3	ratios	ratio	NNS
cord-011917-6u0t4hy8	61	4	may	may	MD
cord-011917-6u0t4hy8	61	5	also	also	RB
cord-011917-6u0t4hy8	61	6	be	be	VB
cord-011917-6u0t4hy8	61	7	due	due	JJ
cord-011917-6u0t4hy8	61	8	to	to	IN
cord-011917-6u0t4hy8	61	9	the	the	DT
cord-011917-6u0t4hy8	61	10	low	low	JJ
cord-011917-6u0t4hy8	61	11	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	61	12	of	of	IN
cord-011917-6u0t4hy8	61	13	the	the	DT
cord-011917-6u0t4hy8	61	14	influenza	influenza	NN
cord-011917-6u0t4hy8	61	15	vaccine	vaccine	NN
cord-011917-6u0t4hy8	61	16	.	.	.
cord-011917-6u0t4hy8	62	1	In	in	IN
cord-011917-6u0t4hy8	62	2	humans	human	NNS
cord-011917-6u0t4hy8	62	3	,	,	,
cord-011917-6u0t4hy8	62	4	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	62	5	vary	vary	VBP
cord-011917-6u0t4hy8	62	6	in	in	IN
cord-011917-6u0t4hy8	62	7	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	62	8	[	[	-LRB-
cord-011917-6u0t4hy8	62	9	48	48	CD
cord-011917-6u0t4hy8	62	10	]	]	-RRB-
cord-011917-6u0t4hy8	62	11	[	[	-LRB-
cord-011917-6u0t4hy8	62	12	49	49	CD
cord-011917-6u0t4hy8	62	13	]	]	-RRB-
cord-011917-6u0t4hy8	62	14	[	[	-LRB-
cord-011917-6u0t4hy8	62	15	50	50	CD
cord-011917-6u0t4hy8	62	16	]	]	-RRB-
cord-011917-6u0t4hy8	62	17	,	,	,
cord-011917-6u0t4hy8	62	18	particularly	particularly	RB
cord-011917-6u0t4hy8	62	19	in	in	IN
cord-011917-6u0t4hy8	62	20	immunocompromised	immunocompromised	JJ
cord-011917-6u0t4hy8	62	21	adults	adult	NNS
cord-011917-6u0t4hy8	62	22	and	and	CC
cord-011917-6u0t4hy8	62	23	children	child	NNS
cord-011917-6u0t4hy8	62	24	[	[	-LRB-
cord-011917-6u0t4hy8	62	25	51	51	CD
cord-011917-6u0t4hy8	62	26	]	]	-RRB-
cord-011917-6u0t4hy8	62	27	.	.	.
cord-011917-6u0t4hy8	63	1	Due	due	IN
cord-011917-6u0t4hy8	63	2	to	to	IN
cord-011917-6u0t4hy8	63	3	this	this	DT
cord-011917-6u0t4hy8	63	4	issue	issue	NN
cord-011917-6u0t4hy8	63	5	,	,	,
cord-011917-6u0t4hy8	63	6	pandemic	pandemic	NN
cord-011917-6u0t4hy8	63	7	influenza	influenza	NN
cord-011917-6u0t4hy8	63	8	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	63	9	can	can	MD
cord-011917-6u0t4hy8	63	10	be	be	VB
cord-011917-6u0t4hy8	63	11	adjuvanted	adjuvante	VBN
cord-011917-6u0t4hy8	63	12	to	to	TO
cord-011917-6u0t4hy8	63	13	ensure	ensure	VB
cord-011917-6u0t4hy8	63	14	an	an	DT
cord-011917-6u0t4hy8	63	15	efficient	efficient	JJ
cord-011917-6u0t4hy8	63	16	immune	immune	JJ
cord-011917-6u0t4hy8	63	17	response	response	NN
cord-011917-6u0t4hy8	63	18	[	[	-LRB-
cord-011917-6u0t4hy8	63	19	52	52	CD
cord-011917-6u0t4hy8	63	20	]	]	-RRB-
cord-011917-6u0t4hy8	63	21	[	[	-LRB-
cord-011917-6u0t4hy8	63	22	53	53	CD
cord-011917-6u0t4hy8	63	23	]	]	-RRB-
cord-011917-6u0t4hy8	63	24	[	[	-LRB-
cord-011917-6u0t4hy8	63	25	54	54	CD
cord-011917-6u0t4hy8	63	26	]	]	-RRB-
cord-011917-6u0t4hy8	63	27	[	[	-LRB-
cord-011917-6u0t4hy8	63	28	55	55	CD
cord-011917-6u0t4hy8	63	29	]	]	-RRB-
cord-011917-6u0t4hy8	63	30	.	.	.
cord-011917-6u0t4hy8	64	1	With	with	IN
cord-011917-6u0t4hy8	64	2	the	the	DT
cord-011917-6u0t4hy8	64	3	inclusion	inclusion	NN
cord-011917-6u0t4hy8	64	4	of	of	IN
cord-011917-6u0t4hy8	64	5	different	different	JJ
cord-011917-6u0t4hy8	64	6	adjuvants	adjuvant	NNS
cord-011917-6u0t4hy8	64	7	,	,	,
cord-011917-6u0t4hy8	64	8	different	different	JJ
cord-011917-6u0t4hy8	64	9	magnitudes	magnitude	NNS
cord-011917-6u0t4hy8	64	10	of	of	IN
cord-011917-6u0t4hy8	64	11	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	64	12	and	and	CC
cord-011917-6u0t4hy8	64	13	protection	protection	NN
cord-011917-6u0t4hy8	64	14	can	can	MD
cord-011917-6u0t4hy8	64	15	be	be	VB
cord-011917-6u0t4hy8	64	16	achieved	achieve	VBN
cord-011917-6u0t4hy8	64	17	[	[	-LRB-
cord-011917-6u0t4hy8	64	18	47	47	CD
cord-011917-6u0t4hy8	64	19	]	]	-RRB-
cord-011917-6u0t4hy8	64	20	.	.	.
cord-011917-6u0t4hy8	65	1	Some	some	DT
cord-011917-6u0t4hy8	65	2	studies	study	NNS
cord-011917-6u0t4hy8	65	3	used	use	VBD
cord-011917-6u0t4hy8	65	4	virus	virus	NN
cord-011917-6u0t4hy8	65	5	-	-	HYPH
cord-011917-6u0t4hy8	65	6	like	like	JJ
cord-011917-6u0t4hy8	65	7	particle	particle	NN
cord-011917-6u0t4hy8	65	8	(	(	-LRB-
cord-011917-6u0t4hy8	65	9	VLP	VLP	NNP
cord-011917-6u0t4hy8	65	10	)	)	-RRB-
cord-011917-6u0t4hy8	65	11	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	65	12	produced	produce	VBN
cord-011917-6u0t4hy8	65	13	from	from	IN
cord-011917-6u0t4hy8	65	14	insect	insect	NN
cord-011917-6u0t4hy8	65	15	cells	cell	NNS
cord-011917-6u0t4hy8	65	16	using	use	VBG
cord-011917-6u0t4hy8	65	17	a	a	DT
cord-011917-6u0t4hy8	65	18	baculoviral	baculoviral	JJ
cord-011917-6u0t4hy8	65	19	system	system	NN
cord-011917-6u0t4hy8	65	20	which	which	WDT
cord-011917-6u0t4hy8	65	21	results	result	VBZ
cord-011917-6u0t4hy8	65	22	in	in	IN
cord-011917-6u0t4hy8	65	23	100	100	CD
cord-011917-6u0t4hy8	65	24	%	%	NN
cord-011917-6u0t4hy8	65	25	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	65	26	[	[	-LRB-
cord-011917-6u0t4hy8	65	27	56	56	CD
cord-011917-6u0t4hy8	65	28	,	,	,
cord-011917-6u0t4hy8	65	29	57	57	CD
cord-011917-6u0t4hy8	65	30	]	]	-RRB-
cord-011917-6u0t4hy8	65	31	.	.	.
cord-011917-6u0t4hy8	66	1	The	the	DT
cord-011917-6u0t4hy8	66	2	manufacturing	manufacturing	NN
cord-011917-6u0t4hy8	66	3	process	process	NN
cord-011917-6u0t4hy8	66	4	of	of	IN
cord-011917-6u0t4hy8	66	5	these	these	DT
cord-011917-6u0t4hy8	66	6	VLPs	vlp	NNS
cord-011917-6u0t4hy8	66	7	retain	retain	VBP
cord-011917-6u0t4hy8	66	8	insect	insect	NN
cord-011917-6u0t4hy8	66	9	protein	protein	NN
cord-011917-6u0t4hy8	66	10	that	that	WDT
cord-011917-6u0t4hy8	66	11	act	act	VBP
cord-011917-6u0t4hy8	66	12	as	as	IN
cord-011917-6u0t4hy8	66	13	an	an	DT
cord-011917-6u0t4hy8	66	14	adjuvant	adjuvant	NN
cord-011917-6u0t4hy8	66	15	contributing	contribute	VBG
cord-011917-6u0t4hy8	66	16	to	to	IN
cord-011917-6u0t4hy8	66	17	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	66	18	.	.	.
cord-011917-6u0t4hy8	67	1	Research	research	NN
cord-011917-6u0t4hy8	67	2	groups	group	NNS
cord-011917-6u0t4hy8	67	3	have	have	VBP
cord-011917-6u0t4hy8	67	4	attempted	attempt	VBN
cord-011917-6u0t4hy8	67	5	to	to	TO
cord-011917-6u0t4hy8	67	6	solve	solve	VB
cord-011917-6u0t4hy8	67	7	this	this	DT
cord-011917-6u0t4hy8	67	8	phenomenon	phenomenon	NN
cord-011917-6u0t4hy8	67	9	through	through	IN
cord-011917-6u0t4hy8	67	10	multiple	multiple	JJ
cord-011917-6u0t4hy8	67	11	vaccinations	vaccination	NNS
cord-011917-6u0t4hy8	67	12	,	,	,
cord-011917-6u0t4hy8	67	13	i.e.	i.e.	FW
cord-011917-6u0t4hy8	67	14	,	,	,
cord-011917-6u0t4hy8	67	15	a	a	DT
cord-011917-6u0t4hy8	67	16	prime	prime	JJ
cord-011917-6u0t4hy8	67	17	-	-	HYPH
cord-011917-6u0t4hy8	67	18	boost	boost	NN
cord-011917-6u0t4hy8	67	19	or	or	CC
cord-011917-6u0t4hy8	67	20	prime	prime	JJ
cord-011917-6u0t4hy8	67	21	-	-	HYPH
cord-011917-6u0t4hy8	67	22	boost	boost	NN
cord-011917-6u0t4hy8	67	23	-	-	HYPH
cord-011917-6u0t4hy8	67	24	boost	boost	NN
cord-011917-6u0t4hy8	67	25	regimen	regimen	NN
cord-011917-6u0t4hy8	67	26	,	,	,
cord-011917-6u0t4hy8	67	27	or	or	CC
cord-011917-6u0t4hy8	67	28	with	with	IN
cord-011917-6u0t4hy8	67	29	addition	addition	NN
cord-011917-6u0t4hy8	67	30	of	of	IN
cord-011917-6u0t4hy8	67	31	adjuvant	adjuvant	NN
cord-011917-6u0t4hy8	67	32	to	to	TO
cord-011917-6u0t4hy8	67	33	elicit	elicit	VB
cord-011917-6u0t4hy8	67	34	an	an	DT
cord-011917-6u0t4hy8	67	35	antibody	antibody	NN
cord-011917-6u0t4hy8	67	36	response	response	NN
cord-011917-6u0t4hy8	67	37	[	[	-LRB-
cord-011917-6u0t4hy8	67	38	58	58	CD
cord-011917-6u0t4hy8	67	39	]	]	-RRB-
cord-011917-6u0t4hy8	67	40	.	.	.
cord-011917-6u0t4hy8	68	1	Establishment	Establishment	NNP
cord-011917-6u0t4hy8	68	2	of	of	IN
cord-011917-6u0t4hy8	68	3	pre	pre	JJ
cord-011917-6u0t4hy8	68	4	-	-	NN
cord-011917-6u0t4hy8	68	5	immunity	immunity	NN
cord-011917-6u0t4hy8	68	6	overcomes	overcome	VBZ
cord-011917-6u0t4hy8	68	7	this	this	DT
cord-011917-6u0t4hy8	68	8	phenomenon	phenomenon	NN
cord-011917-6u0t4hy8	68	9	;	;	:
cord-011917-6u0t4hy8	68	10	pre	pre	JJ
cord-011917-6u0t4hy8	68	11	-	-	JJ
cord-011917-6u0t4hy8	68	12	immune	immune	JJ
cord-011917-6u0t4hy8	68	13	ferrets	ferret	NNS
cord-011917-6u0t4hy8	68	14	respond	respond	VBP
cord-011917-6u0t4hy8	68	15	to	to	IN
cord-011917-6u0t4hy8	68	16	vaccination	vaccination	NN
cord-011917-6u0t4hy8	68	17	at	at	IN
cord-011917-6u0t4hy8	68	18	a	a	DT
cord-011917-6u0t4hy8	68	19	higher	high	JJR
cord-011917-6u0t4hy8	68	20	proportion	proportion	NN
cord-011917-6u0t4hy8	68	21	than	than	IN
cord-011917-6u0t4hy8	68	22	immunologically	immunologically	RB
cord-011917-6u0t4hy8	68	23	naïve	naïve	JJ
cord-011917-6u0t4hy8	68	24	ferrets	ferret	NNS
cord-011917-6u0t4hy8	68	25	.	.	.
cord-011917-6u0t4hy8	69	1	With	with	IN
cord-011917-6u0t4hy8	69	2	either	either	DT
cord-011917-6u0t4hy8	69	3	type	type	NN
cord-011917-6u0t4hy8	69	4	A	a	DT
cord-011917-6u0t4hy8	69	5	homosubtypic	homosubtypic	NN
cord-011917-6u0t4hy8	69	6	[	[	-LRB-
cord-011917-6u0t4hy8	69	7	59	59	CD
cord-011917-6u0t4hy8	69	8	]	]	-RRB-
cord-011917-6u0t4hy8	69	9	or	or	CC
cord-011917-6u0t4hy8	69	10	heterosubtypic	heterosubtypic	NNP
cord-011917-6u0t4hy8	69	11	[	[	-LRB-
cord-011917-6u0t4hy8	69	12	39	39	CD
cord-011917-6u0t4hy8	69	13	]	]	-RRB-
cord-011917-6u0t4hy8	69	14	pre	pre	JJ
cord-011917-6u0t4hy8	69	15	-	-	NN
cord-011917-6u0t4hy8	69	16	immunity	immunity	NN
cord-011917-6u0t4hy8	69	17	,	,	,
cord-011917-6u0t4hy8	69	18	the	the	DT
cord-011917-6u0t4hy8	69	19	vaccine	vaccine	NN
cord-011917-6u0t4hy8	69	20	-	-	HYPH
cord-011917-6u0t4hy8	69	21	specific	specific	JJ
cord-011917-6u0t4hy8	69	22	serum	serum	NN
cord-011917-6u0t4hy8	69	23	hemagglutinin	hemagglutinin	NN
cord-011917-6u0t4hy8	69	24	inhibition	inhibition	NN
cord-011917-6u0t4hy8	69	25	titers	titer	NNS
cord-011917-6u0t4hy8	69	26	are	be	VBP
cord-011917-6u0t4hy8	69	27	increased	increase	VBN
cord-011917-6u0t4hy8	69	28	.	.	.
cord-011917-6u0t4hy8	70	1	Imprinting	imprinting	NN
cord-011917-6u0t4hy8	70	2	primed	prime	VBD
cord-011917-6u0t4hy8	70	3	the	the	DT
cord-011917-6u0t4hy8	70	4	immune	immune	JJ
cord-011917-6u0t4hy8	70	5	system	system	NN
cord-011917-6u0t4hy8	70	6	towards	towards	IN
cord-011917-6u0t4hy8	70	7	future	future	JJ
cord-011917-6u0t4hy8	70	8	influenza	influenza	NN
cord-011917-6u0t4hy8	70	9	vaccinations	vaccination	NNS
cord-011917-6u0t4hy8	70	10	.	.	.
cord-011917-6u0t4hy8	71	1	This	this	DT
cord-011917-6u0t4hy8	71	2	priming	priming	NN
cord-011917-6u0t4hy8	71	3	phenomenon	phenomenon	NN
cord-011917-6u0t4hy8	71	4	is	be	VBZ
cord-011917-6u0t4hy8	71	5	not	not	RB
cord-011917-6u0t4hy8	71	6	only	only	RB
cord-011917-6u0t4hy8	71	7	present	present	JJ
cord-011917-6u0t4hy8	71	8	in	in	IN
cord-011917-6u0t4hy8	71	9	the	the	DT
cord-011917-6u0t4hy8	71	10	ferret	ferret	NN
cord-011917-6u0t4hy8	71	11	animal	animal	NN
cord-011917-6u0t4hy8	71	12	model	model	NN
cord-011917-6u0t4hy8	71	13	,	,	,
cord-011917-6u0t4hy8	71	14	but	but	CC
cord-011917-6u0t4hy8	71	15	also	also	RB
cord-011917-6u0t4hy8	71	16	occurs	occur	VBZ
cord-011917-6u0t4hy8	71	17	in	in	IN
cord-011917-6u0t4hy8	71	18	mice	mouse	NNS
cord-011917-6u0t4hy8	71	19	and	and	CC
cord-011917-6u0t4hy8	71	20	hamsters	hamster	NNS
cord-011917-6u0t4hy8	72	1	[	[	-LRB-
cord-011917-6u0t4hy8	72	2	60	60	CD
cord-011917-6u0t4hy8	72	3	]	]	-RRB-
cord-011917-6u0t4hy8	72	4	[	[	-LRB-
cord-011917-6u0t4hy8	72	5	61	61	CD
cord-011917-6u0t4hy8	72	6	]	]	-RRB-
cord-011917-6u0t4hy8	73	1	[	[	-LRB-
cord-011917-6u0t4hy8	73	2	62	62	CD
cord-011917-6u0t4hy8	73	3	]	]	-RRB-
cord-011917-6u0t4hy8	73	4	.	.	.
cord-011917-6u0t4hy8	74	1	One	one	CD
cord-011917-6u0t4hy8	74	2	of	of	IN
cord-011917-6u0t4hy8	74	3	the	the	DT
cord-011917-6u0t4hy8	74	4	earliest	early	JJS
cord-011917-6u0t4hy8	74	5	works	work	NNS
cord-011917-6u0t4hy8	74	6	with	with	IN
cord-011917-6u0t4hy8	74	7	pre	pre	JJ
cord-011917-6u0t4hy8	74	8	-	-	NN
cord-011917-6u0t4hy8	74	9	immunity	immunity	NN
cord-011917-6u0t4hy8	74	10	in	in	IN
cord-011917-6u0t4hy8	74	11	ferrets	ferret	NNS
cord-011917-6u0t4hy8	74	12	was	be	VBD
cord-011917-6u0t4hy8	74	13	conducted	conduct	VBN
cord-011917-6u0t4hy8	74	14	by	by	IN
cord-011917-6u0t4hy8	74	15	Webster	Webster	NNP
cord-011917-6u0t4hy8	74	16	in	in	IN
cord-011917-6u0t4hy8	74	17	1966	1966	CD
cord-011917-6u0t4hy8	74	18	investigating	investigate	VBG
cord-011917-6u0t4hy8	74	19	the	the	DT
cord-011917-6u0t4hy8	74	20	presence	presence	NN
cord-011917-6u0t4hy8	74	21	of	of	IN
cord-011917-6u0t4hy8	74	22	original	original	JJ
cord-011917-6u0t4hy8	74	23	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	74	24	sin	sin	NN
cord-011917-6u0t4hy8	74	25	in	in	IN
cord-011917-6u0t4hy8	74	26	ferrets	ferret	NNS
cord-011917-6u0t4hy8	74	27	by	by	IN
cord-011917-6u0t4hy8	74	28	conducting	conduct	VBG
cord-011917-6u0t4hy8	74	29	sequential	sequential	JJ
cord-011917-6u0t4hy8	74	30	infections	infection	NNS
cord-011917-6u0t4hy8	74	31	[	[	-LRB-
cord-011917-6u0t4hy8	74	32	63	63	CD
cord-011917-6u0t4hy8	74	33	]	]	-RRB-
cord-011917-6u0t4hy8	74	34	.	.	.
cord-011917-6u0t4hy8	75	1	Following	follow	VBG
cord-011917-6u0t4hy8	75	2	this	this	DT
cord-011917-6u0t4hy8	75	3	,	,	,
cord-011917-6u0t4hy8	75	4	in	in	IN
cord-011917-6u0t4hy8	75	5	the	the	DT
cord-011917-6u0t4hy8	75	6	1970s	1970	NNS
cord-011917-6u0t4hy8	75	7	,	,	,
cord-011917-6u0t4hy8	75	8	a	a	DT
cord-011917-6u0t4hy8	75	9	vast	vast	JJ
cord-011917-6u0t4hy8	75	10	amount	amount	NN
cord-011917-6u0t4hy8	75	11	of	of	IN
cord-011917-6u0t4hy8	75	12	pre	pre	JJ
cord-011917-6u0t4hy8	75	13	-	-	JJ
cord-011917-6u0t4hy8	75	14	immunity	immunity	JJ
cord-011917-6u0t4hy8	75	15	work	work	NN
cord-011917-6u0t4hy8	75	16	was	be	VBD
cord-011917-6u0t4hy8	75	17	conducted	conduct	VBN
cord-011917-6u0t4hy8	75	18	with	with	IN
cord-011917-6u0t4hy8	75	19	ferrets	ferret	NNS
cord-011917-6u0t4hy8	75	20	.	.	.
cord-011917-6u0t4hy8	76	1	These	these	DT
cord-011917-6u0t4hy8	76	2	studies	study	NNS
cord-011917-6u0t4hy8	76	3	focused	focus	VBD
cord-011917-6u0t4hy8	76	4	on	on	IN
cord-011917-6u0t4hy8	76	5	characterizing	characterize	VBG
cord-011917-6u0t4hy8	76	6	the	the	DT
cord-011917-6u0t4hy8	76	7	ferret	ferret	JJ
cord-011917-6u0t4hy8	76	8	immune	immune	JJ
cord-011917-6u0t4hy8	76	9	system	system	NN
cord-011917-6u0t4hy8	76	10	response	response	NN
cord-011917-6u0t4hy8	76	11	to	to	TO
cord-011917-6u0t4hy8	76	12	live	live	VB
cord-011917-6u0t4hy8	76	13	and	and	CC
cord-011917-6u0t4hy8	76	14	killed	kill	VBD
cord-011917-6u0t4hy8	76	15	virus	virus	NN
cord-011917-6u0t4hy8	76	16	,	,	,
cord-011917-6u0t4hy8	76	17	vaccination	vaccination	NN
cord-011917-6u0t4hy8	76	18	,	,	,
cord-011917-6u0t4hy8	76	19	adjuvant	adjuvant	NN
cord-011917-6u0t4hy8	76	20	and	and	CC
cord-011917-6u0t4hy8	76	21	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	76	22	and	and	CC
cord-011917-6u0t4hy8	76	23	heterologous	heterologous	JJ
cord-011917-6u0t4hy8	76	24	infections	infection	NNS
cord-011917-6u0t4hy8	76	25	[	[	-LRB-
cord-011917-6u0t4hy8	76	26	39	39	CD
cord-011917-6u0t4hy8	76	27	,	,	,
cord-011917-6u0t4hy8	76	28	45	45	CD
cord-011917-6u0t4hy8	76	29	,	,	,
cord-011917-6u0t4hy8	76	30	46	46	CD
cord-011917-6u0t4hy8	76	31	,	,	,
cord-011917-6u0t4hy8	76	32	[	[	-LRB-
cord-011917-6u0t4hy8	76	33	64	64	CD
cord-011917-6u0t4hy8	76	34	]	]	-RRB-
cord-011917-6u0t4hy8	76	35	[	[	-LRB-
cord-011917-6u0t4hy8	76	36	65	65	CD
cord-011917-6u0t4hy8	76	37	]	]	-RRB-
cord-011917-6u0t4hy8	76	38	[	[	-LRB-
cord-011917-6u0t4hy8	76	39	66	66	CD
cord-011917-6u0t4hy8	76	40	]	]	-RRB-
cord-011917-6u0t4hy8	76	41	[	[	-LRB-
cord-011917-6u0t4hy8	76	42	67	67	CD
cord-011917-6u0t4hy8	76	43	]	]	-RRB-
cord-011917-6u0t4hy8	76	44	.	.	.
cord-011917-6u0t4hy8	77	1	Further	further	RB
cord-011917-6u0t4hy8	77	2	,	,	,
cord-011917-6u0t4hy8	77	3	heterosubtypic	heterosubtypic	JJ
cord-011917-6u0t4hy8	77	4	immunity	immunity	NN
cord-011917-6u0t4hy8	77	5	was	be	VBD
cord-011917-6u0t4hy8	77	6	shown	show	VBN
cord-011917-6u0t4hy8	77	7	not	not	RB
cord-011917-6u0t4hy8	77	8	to	to	TO
cord-011917-6u0t4hy8	77	9	wane	wane	VB
cord-011917-6u0t4hy8	77	10	over	over	IN
cord-011917-6u0t4hy8	77	11	a	a	DT
cord-011917-6u0t4hy8	77	12	period	period	NN
cord-011917-6u0t4hy8	77	13	of	of	IN
cord-011917-6u0t4hy8	77	14	up	up	IN
cord-011917-6u0t4hy8	77	15	to	to	TO
cord-011917-6u0t4hy8	77	16	eighteen	eighteen	CD
cord-011917-6u0t4hy8	77	17	months	month	NNS
cord-011917-6u0t4hy8	77	18	[	[	-LRB-
cord-011917-6u0t4hy8	77	19	68	68	CD
cord-011917-6u0t4hy8	77	20	]	]	-RRB-
cord-011917-6u0t4hy8	77	21	.	.	.
cord-011917-6u0t4hy8	78	1	This	this	DT
cord-011917-6u0t4hy8	78	2	historical	historical	JJ
cord-011917-6u0t4hy8	78	3	collection	collection	NN
cord-011917-6u0t4hy8	78	4	of	of	IN
cord-011917-6u0t4hy8	78	5	ferret	ferret	JJ
cord-011917-6u0t4hy8	78	6	research	research	NN
cord-011917-6u0t4hy8	78	7	laid	lay	VBD
cord-011917-6u0t4hy8	78	8	the	the	DT
cord-011917-6u0t4hy8	78	9	foundation	foundation	NN
cord-011917-6u0t4hy8	78	10	for	for	IN
cord-011917-6u0t4hy8	78	11	showing	show	VBG
cord-011917-6u0t4hy8	78	12	that	that	DT
cord-011917-6u0t4hy8	78	13	low	low	JJ
cord-011917-6u0t4hy8	78	14	vaccination	vaccination	NN
cord-011917-6u0t4hy8	78	15	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	78	16	proportions	proportion	NNS
cord-011917-6u0t4hy8	78	17	for	for	IN
cord-011917-6u0t4hy8	78	18	naïve	naïve	JJ
cord-011917-6u0t4hy8	78	19	ferrets	ferret	NNS
cord-011917-6u0t4hy8	78	20	can	can	MD
cord-011917-6u0t4hy8	78	21	be	be	VB
cord-011917-6u0t4hy8	78	22	overcome	overcome	VBN
cord-011917-6u0t4hy8	78	23	by	by	IN
cord-011917-6u0t4hy8	78	24	the	the	DT
cord-011917-6u0t4hy8	78	25	development	development	NN
cord-011917-6u0t4hy8	78	26	and	and	CC
cord-011917-6u0t4hy8	78	27	optimization	optimization	NN
cord-011917-6u0t4hy8	78	28	of	of	IN
cord-011917-6u0t4hy8	78	29	a	a	DT
cord-011917-6u0t4hy8	78	30	pre	pre	JJ
cord-011917-6u0t4hy8	78	31	-	-	JJ
cord-011917-6u0t4hy8	78	32	immune	immune	JJ
cord-011917-6u0t4hy8	78	33	animal	animal	NN
cord-011917-6u0t4hy8	78	34	model	model	NN
cord-011917-6u0t4hy8	78	35	.	.	.
cord-011917-6u0t4hy8	79	1	The	the	DT
cord-011917-6u0t4hy8	79	2	pre	pre	JJ
cord-011917-6u0t4hy8	79	3	-	-	JJ
cord-011917-6u0t4hy8	79	4	immune	immune	JJ
cord-011917-6u0t4hy8	79	5	model	model	NN
cord-011917-6u0t4hy8	79	6	never	never	RB
cord-011917-6u0t4hy8	79	7	advanced	advance	VBN
cord-011917-6u0t4hy8	79	8	after	after	IN
cord-011917-6u0t4hy8	79	9	this	this	DT
cord-011917-6u0t4hy8	79	10	time	time	NN
cord-011917-6u0t4hy8	79	11	,	,	,
cord-011917-6u0t4hy8	79	12	potentially	potentially	RB
cord-011917-6u0t4hy8	79	13	due	due	IN
cord-011917-6u0t4hy8	79	14	to	to	IN
cord-011917-6u0t4hy8	79	15	the	the	DT
cord-011917-6u0t4hy8	79	16	lack	lack	NN
cord-011917-6u0t4hy8	79	17	of	of	IN
cord-011917-6u0t4hy8	79	18	immunological	immunological	JJ
cord-011917-6u0t4hy8	79	19	reagents	reagent	NNS
cord-011917-6u0t4hy8	79	20	and	and	CC
cord-011917-6u0t4hy8	79	21	tools	tool	NNS
cord-011917-6u0t4hy8	79	22	needed	need	VBN
cord-011917-6u0t4hy8	79	23	to	to	TO
cord-011917-6u0t4hy8	79	24	properly	properly	RB
cord-011917-6u0t4hy8	79	25	characterize	characterize	VB
cord-011917-6u0t4hy8	79	26	the	the	DT
cord-011917-6u0t4hy8	79	27	model	model	NN
cord-011917-6u0t4hy8	79	28	and	and	CC
cord-011917-6u0t4hy8	79	29	general	general	JJ
cord-011917-6u0t4hy8	79	30	ignorance	ignorance	NN
cord-011917-6u0t4hy8	79	31	of	of	IN
cord-011917-6u0t4hy8	79	32	the	the	DT
cord-011917-6u0t4hy8	79	33	magnitude	magnitude	NN
cord-011917-6u0t4hy8	79	34	imprinting	imprinting	NN
cord-011917-6u0t4hy8	79	35	and	and	CC
cord-011917-6u0t4hy8	79	36	pre	pre	JJ
cord-011917-6u0t4hy8	79	37	-	-	JJ
cord-011917-6u0t4hy8	79	38	immunity	immunity	JJ
cord-011917-6u0t4hy8	79	39	contributes	contribute	VBZ
cord-011917-6u0t4hy8	79	40	towards	towards	IN
cord-011917-6u0t4hy8	79	41	vaccination	vaccination	NN
cord-011917-6u0t4hy8	79	42	and	and	CC
cord-011917-6u0t4hy8	79	43	infection	infection	NN
cord-011917-6u0t4hy8	79	44	.	.	.
cord-011917-6u0t4hy8	80	1	After	after	IN
cord-011917-6u0t4hy8	80	2	a	a	DT
cord-011917-6u0t4hy8	80	3	lull	lull	NN
cord-011917-6u0t4hy8	80	4	in	in	IN
cord-011917-6u0t4hy8	80	5	the	the	DT
cord-011917-6u0t4hy8	80	6	pre	pre	JJ
cord-011917-6u0t4hy8	80	7	-	-	JJ
cord-011917-6u0t4hy8	80	8	immune	immune	JJ
cord-011917-6u0t4hy8	80	9	ferret	ferret	NN
cord-011917-6u0t4hy8	80	10	research	research	NN
cord-011917-6u0t4hy8	80	11	,	,	,
cord-011917-6u0t4hy8	80	12	the	the	DT
cord-011917-6u0t4hy8	80	13	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	80	14	)	)	-RRB-
cord-011917-6u0t4hy8	80	15	2009	2009	CD
cord-011917-6u0t4hy8	80	16	swine	swine	NN
cord-011917-6u0t4hy8	80	17	influenza	influenza	NN
cord-011917-6u0t4hy8	80	18	pandemic	pandemic	NN
cord-011917-6u0t4hy8	80	19	initiated	initiate	VBD
cord-011917-6u0t4hy8	80	20	the	the	DT
cord-011917-6u0t4hy8	80	21	dramatic	dramatic	JJ
cord-011917-6u0t4hy8	80	22	increase	increase	NN
cord-011917-6u0t4hy8	80	23	of	of	IN
cord-011917-6u0t4hy8	80	24	the	the	DT
cord-011917-6u0t4hy8	80	25	investigative	investigative	JJ
cord-011917-6u0t4hy8	80	26	effort	effort	NN
cord-011917-6u0t4hy8	80	27	into	into	IN
cord-011917-6u0t4hy8	80	28	imprinting	imprinting	NN
cord-011917-6u0t4hy8	80	29	,	,	,
cord-011917-6u0t4hy8	80	30	pre	pre	JJ
cord-011917-6u0t4hy8	80	31	-	-	NN
cord-011917-6u0t4hy8	80	32	immunity	immunity	NN
cord-011917-6u0t4hy8	80	33	,	,	,
cord-011917-6u0t4hy8	80	34	and	and	CC
cord-011917-6u0t4hy8	80	35	heterologous	heterologous	NNP
cord-011917-6u0t4hy8	80	36	protection	protection	NN
cord-011917-6u0t4hy8	80	37	.	.	.
cord-011917-6u0t4hy8	81	1	The	the	DT
cord-011917-6u0t4hy8	81	2	early	early	JJ
cord-011917-6u0t4hy8	81	3	epidemiological	epidemiological	JJ
cord-011917-6u0t4hy8	81	4	and	and	CC
cord-011917-6u0t4hy8	81	5	serological	serological	JJ
cord-011917-6u0t4hy8	81	6	studies	study	NNS
cord-011917-6u0t4hy8	81	7	that	that	WDT
cord-011917-6u0t4hy8	81	8	inspired	inspire	VBD
cord-011917-6u0t4hy8	81	9	this	this	DT
cord-011917-6u0t4hy8	81	10	interest	interest	NN
cord-011917-6u0t4hy8	81	11	suggested	suggest	VBD
cord-011917-6u0t4hy8	81	12	that	that	IN
cord-011917-6u0t4hy8	81	13	pre	pre	JJ
cord-011917-6u0t4hy8	81	14	-	-	JJ
cord-011917-6u0t4hy8	81	15	existing	existing	JJ
cord-011917-6u0t4hy8	81	16	immunity	immunity	NN
cord-011917-6u0t4hy8	81	17	may	may	MD
cord-011917-6u0t4hy8	81	18	have	have	VB
cord-011917-6u0t4hy8	81	19	altered	alter	VBN
cord-011917-6u0t4hy8	81	20	the	the	DT
cord-011917-6u0t4hy8	81	21	pandemic	pandemic	NN
cord-011917-6u0t4hy8	81	22	virus	virus	NN
cord-011917-6u0t4hy8	81	23	'	'	''
cord-011917-6u0t4hy8	81	24	morbidity	morbidity	NN
cord-011917-6u0t4hy8	81	25	and	and	CC
cord-011917-6u0t4hy8	81	26	mortality	mortality	NN
cord-011917-6u0t4hy8	81	27	in	in	IN
cord-011917-6u0t4hy8	81	28	the	the	DT
cord-011917-6u0t4hy8	81	29	human	human	JJ
cord-011917-6u0t4hy8	81	30	population	population	NN
cord-011917-6u0t4hy8	81	31	[	[	-LRB-
cord-011917-6u0t4hy8	81	32	9	9	CD
cord-011917-6u0t4hy8	81	33	,	,	,
cord-011917-6u0t4hy8	81	34	69	69	CD
cord-011917-6u0t4hy8	81	35	]	]	-RRB-
cord-011917-6u0t4hy8	81	36	.	.	.
cord-011917-6u0t4hy8	82	1	The	the	DT
cord-011917-6u0t4hy8	82	2	resultant	resultant	JJ
cord-011917-6u0t4hy8	82	3	pre	pre	JJ
cord-011917-6u0t4hy8	82	4	-	-	JJ
cord-011917-6u0t4hy8	82	5	immunity	immunity	JJ
cord-011917-6u0t4hy8	82	6	models	model	NNS
cord-011917-6u0t4hy8	82	7	were	be	VBD
cord-011917-6u0t4hy8	82	8	based	base	VBN
cord-011917-6u0t4hy8	82	9	upon	upon	IN
cord-011917-6u0t4hy8	82	10	the	the	DT
cord-011917-6u0t4hy8	82	11	historical	historical	JJ
cord-011917-6u0t4hy8	82	12	model	model	NN
cord-011917-6u0t4hy8	82	13	:	:	:
cord-011917-6u0t4hy8	82	14	(	(	-LRB-
cord-011917-6u0t4hy8	82	15	1	1	LS
cord-011917-6u0t4hy8	82	16	)	)	-RRB-
cord-011917-6u0t4hy8	82	17	establish	establish	VB
cord-011917-6u0t4hy8	82	18	anti	anti	JJ
cord-011917-6u0t4hy8	82	19	-	-	JJ
cord-011917-6u0t4hy8	82	20	influenza	influenza	JJ
cord-011917-6u0t4hy8	82	21	virus	virus	NN
cord-011917-6u0t4hy8	82	22	immune	immune	JJ
cord-011917-6u0t4hy8	82	23	memory	memory	NN
cord-011917-6u0t4hy8	82	24	with	with	IN
cord-011917-6u0t4hy8	82	25	sub	sub	JJ
cord-011917-6u0t4hy8	82	26	-	-	JJ
cord-011917-6u0t4hy8	82	27	lethal	lethal	JJ
cord-011917-6u0t4hy8	82	28	viral	viral	JJ
cord-011917-6u0t4hy8	82	29	challenge	challenge	NN
cord-011917-6u0t4hy8	82	30	;	;	:
cord-011917-6u0t4hy8	82	31	(	(	-LRB-
cord-011917-6u0t4hy8	82	32	2	2	LS
cord-011917-6u0t4hy8	82	33	)	)	-RRB-
cord-011917-6u0t4hy8	82	34	assess	assess	VB
cord-011917-6u0t4hy8	82	35	for	for	IN
cord-011917-6u0t4hy8	82	36	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	82	37	;	;	,
cord-011917-6u0t4hy8	82	38	(	(	-LRB-
cord-011917-6u0t4hy8	82	39	3	3	LS
cord-011917-6u0t4hy8	82	40	)	)	-RRB-
cord-011917-6u0t4hy8	82	41	vaccinate	vaccinate	VB
cord-011917-6u0t4hy8	82	42	,	,	,
cord-011917-6u0t4hy8	82	43	if	if	IN
cord-011917-6u0t4hy8	82	44	necessary	necessary	JJ
cord-011917-6u0t4hy8	82	45	;	;	:
cord-011917-6u0t4hy8	82	46	(	(	-LRB-
cord-011917-6u0t4hy8	82	47	4	4	LS
cord-011917-6u0t4hy8	82	48	)	)	-RRB-
cord-011917-6u0t4hy8	82	49	challenge	challenge	VB
cord-011917-6u0t4hy8	82	50	with	with	IN
cord-011917-6u0t4hy8	82	51	A(H1N1)/California/2009	a(h1n1)/california/2009	NN
cord-011917-6u0t4hy8	82	52	.	.	.
cord-011917-6u0t4hy8	83	1	A	a	DT
cord-011917-6u0t4hy8	83	2	prolonged	prolonged	JJ
cord-011917-6u0t4hy8	83	3	period	period	NN
cord-011917-6u0t4hy8	83	4	of	of	IN
cord-011917-6u0t4hy8	83	5	rest	rest	NN
cord-011917-6u0t4hy8	83	6	between	between	IN
cord-011917-6u0t4hy8	83	7	imprinting	imprinting	NN
cord-011917-6u0t4hy8	83	8	and	and	CC
cord-011917-6u0t4hy8	83	9	vaccination	vaccination	NN
cord-011917-6u0t4hy8	83	10	or	or	CC
cord-011917-6u0t4hy8	83	11	challenge	challenge	NN
cord-011917-6u0t4hy8	83	12	allows	allow	VBZ
cord-011917-6u0t4hy8	83	13	the	the	DT
cord-011917-6u0t4hy8	83	14	ferret	ferret	NN
cord-011917-6u0t4hy8	83	15	to	to	TO
cord-011917-6u0t4hy8	83	16	return	return	VB
cord-011917-6u0t4hy8	83	17	to	to	IN
cord-011917-6u0t4hy8	83	18	an	an	DT
cord-011917-6u0t4hy8	83	19	assumed	assume	VBN
cord-011917-6u0t4hy8	83	20	immunological	immunological	JJ
cord-011917-6u0t4hy8	83	21	baseline	baseline	NN
cord-011917-6u0t4hy8	83	22	after	after	IN
cord-011917-6u0t4hy8	83	23	the	the	DT
cord-011917-6u0t4hy8	83	24	generation	generation	NN
cord-011917-6u0t4hy8	83	25	of	of	IN
cord-011917-6u0t4hy8	83	26	an	an	DT
cord-011917-6u0t4hy8	83	27	adaptive	adaptive	JJ
cord-011917-6u0t4hy8	83	28	memory	memory	NN
cord-011917-6u0t4hy8	83	29	response	response	NN
cord-011917-6u0t4hy8	83	30	and	and	CC
cord-011917-6u0t4hy8	83	31	recovery	recovery	NN
cord-011917-6u0t4hy8	83	32	from	from	IN
cord-011917-6u0t4hy8	83	33	damage	damage	NN
cord-011917-6u0t4hy8	83	34	and	and	CC
cord-011917-6u0t4hy8	83	35	local	local	JJ
cord-011917-6u0t4hy8	83	36	cellular	cellular	JJ
cord-011917-6u0t4hy8	83	37	activation	activation	NN
cord-011917-6u0t4hy8	83	38	in	in	IN
cord-011917-6u0t4hy8	83	39	the	the	DT
cord-011917-6u0t4hy8	83	40	lung	lung	NN
cord-011917-6u0t4hy8	83	41	tissue	tissue	NN
cord-011917-6u0t4hy8	83	42	.	.	.
cord-011917-6u0t4hy8	84	1	Compared	compare	VBN
cord-011917-6u0t4hy8	84	2	to	to	IN
cord-011917-6u0t4hy8	84	3	the	the	DT
cord-011917-6u0t4hy8	84	4	1970s	1970	NNS
cord-011917-6u0t4hy8	84	5	,	,	,
cord-011917-6u0t4hy8	84	6	the	the	DT
cord-011917-6u0t4hy8	84	7	drastic	drastic	JJ
cord-011917-6u0t4hy8	84	8	increase	increase	NN
cord-011917-6u0t4hy8	84	9	in	in	IN
cord-011917-6u0t4hy8	84	10	the	the	DT
cord-011917-6u0t4hy8	84	11	understanding	understanding	NN
cord-011917-6u0t4hy8	84	12	of	of	IN
cord-011917-6u0t4hy8	84	13	the	the	DT
cord-011917-6u0t4hy8	84	14	immune	immune	JJ
cord-011917-6u0t4hy8	84	15	system	system	NN
cord-011917-6u0t4hy8	84	16	,	,	,
cord-011917-6u0t4hy8	84	17	the	the	DT
cord-011917-6u0t4hy8	84	18	effects	effect	NNS
cord-011917-6u0t4hy8	84	19	induced	induce	VBN
cord-011917-6u0t4hy8	84	20	from	from	IN
cord-011917-6u0t4hy8	84	21	influenza	influenza	NN
cord-011917-6u0t4hy8	84	22	challenge	challenge	NN
cord-011917-6u0t4hy8	84	23	and	and	CC
cord-011917-6u0t4hy8	84	24	vaccination	vaccination	NN
cord-011917-6u0t4hy8	84	25	,	,	,
cord-011917-6u0t4hy8	84	26	and	and	CC
cord-011917-6u0t4hy8	84	27	the	the	DT
cord-011917-6u0t4hy8	84	28	ability	ability	NN
cord-011917-6u0t4hy8	84	29	to	to	TO
cord-011917-6u0t4hy8	84	30	measure	measure	VB
cord-011917-6u0t4hy8	84	31	and	and	CC
cord-011917-6u0t4hy8	84	32	quantify	quantify	VB
cord-011917-6u0t4hy8	84	33	these	these	DT
cord-011917-6u0t4hy8	84	34	important	important	JJ
cord-011917-6u0t4hy8	84	35	details	detail	NNS
cord-011917-6u0t4hy8	84	36	allowed	allow	VBN
cord-011917-6u0t4hy8	84	37	for	for	IN
cord-011917-6u0t4hy8	84	38	a	a	DT
cord-011917-6u0t4hy8	84	39	well	well	RB
cord-011917-6u0t4hy8	84	40	-	-	HYPH
cord-011917-6u0t4hy8	84	41	defined	define	VBN
cord-011917-6u0t4hy8	84	42	model	model	NN
cord-011917-6u0t4hy8	84	43	.	.	.
cord-011917-6u0t4hy8	85	1	The	the	DT
cord-011917-6u0t4hy8	85	2	worldwide	worldwide	JJ
cord-011917-6u0t4hy8	85	3	2009	2009	CD
cord-011917-6u0t4hy8	85	4	pandemic	pandemic	NN
cord-011917-6u0t4hy8	85	5	inspired	inspire	VBD
cord-011917-6u0t4hy8	85	6	much	much	JJ
cord-011917-6u0t4hy8	85	7	research	research	NN
cord-011917-6u0t4hy8	85	8	looking	look	VBG
cord-011917-6u0t4hy8	85	9	at	at	IN
cord-011917-6u0t4hy8	85	10	the	the	DT
cord-011917-6u0t4hy8	85	11	protective	protective	JJ
cord-011917-6u0t4hy8	85	12	effects	effect	NNS
cord-011917-6u0t4hy8	85	13	of	of	IN
cord-011917-6u0t4hy8	85	14	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	85	15	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	85	16	)	)	-RRB-
cord-011917-6u0t4hy8	85	17	imprinting	imprinting	NN
cord-011917-6u0t4hy8	85	18	on	on	IN
cord-011917-6u0t4hy8	85	19	the	the	DT
cord-011917-6u0t4hy8	85	20	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	85	21	)	)	-RRB-
cord-011917-6u0t4hy8	86	1	2009	2009	CD
cord-011917-6u0t4hy8	86	2	pandemic	pandemic	NN
cord-011917-6u0t4hy8	86	3	strain	strain	NN
cord-011917-6u0t4hy8	86	4	.	.	.
cord-011917-6u0t4hy8	87	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	87	2	,	,	,
cord-011917-6u0t4hy8	87	3	much	much	JJ
cord-011917-6u0t4hy8	87	4	of	of	IN
cord-011917-6u0t4hy8	87	5	the	the	DT
cord-011917-6u0t4hy8	87	6	published	publish	VBN
cord-011917-6u0t4hy8	87	7	research	research	NN
cord-011917-6u0t4hy8	87	8	has	have	VBZ
cord-011917-6u0t4hy8	87	9	focused	focus	VBN
cord-011917-6u0t4hy8	87	10	on	on	IN
cord-011917-6u0t4hy8	87	11	the	the	DT
cord-011917-6u0t4hy8	87	12	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	87	13	)	)	-RRB-
cord-011917-6u0t4hy8	87	14	subtype	subtype	NN
cord-011917-6u0t4hy8	87	15	(	(	-LRB-
cord-011917-6u0t4hy8	87	16	Tables	Tables	NNPS
cord-011917-6u0t4hy8	87	17	S1	S1	NNP
cord-011917-6u0t4hy8	87	18	and	and	CC
cord-011917-6u0t4hy8	87	19	S2	S2	NNP
cord-011917-6u0t4hy8	87	20	)	)	-RRB-
cord-011917-6u0t4hy8	87	21	.	.	.
cord-011917-6u0t4hy8	88	1	Sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	88	2	immunity	immunity	NN
cord-011917-6u0t4hy8	88	3	in	in	IN
cord-011917-6u0t4hy8	88	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	88	5	,	,	,
cord-011917-6u0t4hy8	88	6	an	an	DT
cord-011917-6u0t4hy8	88	7	immune	immune	JJ
cord-011917-6u0t4hy8	88	8	state	state	NN
cord-011917-6u0t4hy8	88	9	that	that	WDT
cord-011917-6u0t4hy8	88	10	blocks	block	VBZ
cord-011917-6u0t4hy8	88	11	viral	viral	JJ
cord-011917-6u0t4hy8	88	12	infection	infection	NN
cord-011917-6u0t4hy8	88	13	[	[	-LRB-
cord-011917-6u0t4hy8	88	14	41	41	CD
cord-011917-6u0t4hy8	88	15	]	]	-RRB-
cord-011917-6u0t4hy8	88	16	,	,	,
cord-011917-6u0t4hy8	88	17	can	can	MD
cord-011917-6u0t4hy8	88	18	be	be	VB
cord-011917-6u0t4hy8	88	19	achieved	achieve	VBN
cord-011917-6u0t4hy8	88	20	through	through	IN
cord-011917-6u0t4hy8	88	21	establishing	establish	VBG
cord-011917-6u0t4hy8	88	22	pre	pre	JJ
cord-011917-6u0t4hy8	88	23	-	-	NN
cord-011917-6u0t4hy8	88	24	immunity	immunity	JJ
cord-011917-6u0t4hy8	88	25	[	[	-LRB-
cord-011917-6u0t4hy8	88	26	70	70	CD
cord-011917-6u0t4hy8	88	27	]	]	-RRB-
cord-011917-6u0t4hy8	88	28	.	.	.
cord-011917-6u0t4hy8	89	1	Whereas	whereas	IN
cord-011917-6u0t4hy8	89	2	,	,	,
cord-011917-6u0t4hy8	89	3	with	with	IN
cord-011917-6u0t4hy8	89	4	an	an	DT
cord-011917-6u0t4hy8	89	5	intramuscular	intramuscular	JJ
cord-011917-6u0t4hy8	89	6	vaccination	vaccination	NN
cord-011917-6u0t4hy8	89	7	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	89	8	infection	infection	NN
cord-011917-6u0t4hy8	89	9	was	be	VBD
cord-011917-6u0t4hy8	89	10	not	not	RB
cord-011917-6u0t4hy8	89	11	inhibited	inhibit	VBN
cord-011917-6u0t4hy8	89	12	,	,	,
cord-011917-6u0t4hy8	89	13	although	although	IN
cord-011917-6u0t4hy8	89	14	virus	virus	NN
cord-011917-6u0t4hy8	89	15	shedding	shed	VBG
cord-011917-6u0t4hy8	89	16	was	be	VBD
cord-011917-6u0t4hy8	89	17	reduced	reduce	VBN
cord-011917-6u0t4hy8	89	18	.	.	.
cord-011917-6u0t4hy8	90	1	The	the	DT
cord-011917-6u0t4hy8	90	2	gathered	gather	VBN
cord-011917-6u0t4hy8	90	3	data	datum	NNS
cord-011917-6u0t4hy8	90	4	from	from	IN
cord-011917-6u0t4hy8	90	5	this	this	DT
cord-011917-6u0t4hy8	90	6	study	study	NN
cord-011917-6u0t4hy8	90	7	were	be	VBD
cord-011917-6u0t4hy8	90	8	restricted	restrict	VBN
cord-011917-6u0t4hy8	90	9	to	to	IN
cord-011917-6u0t4hy8	90	10	viral	viral	JJ
cord-011917-6u0t4hy8	90	11	characteristics	characteristic	NNS
cord-011917-6u0t4hy8	90	12	,	,	,
cord-011917-6u0t4hy8	90	13	such	such	JJ
cord-011917-6u0t4hy8	90	14	as	as	IN
cord-011917-6u0t4hy8	90	15	virus	virus	NN
cord-011917-6u0t4hy8	90	16	shedding	shedding	NN
cord-011917-6u0t4hy8	90	17	,	,	,
cord-011917-6u0t4hy8	90	18	transmission	transmission	NN
cord-011917-6u0t4hy8	90	19	frequency	frequency	NN
cord-011917-6u0t4hy8	90	20	and	and	CC
cord-011917-6u0t4hy8	90	21	morbidity	morbidity	NN
cord-011917-6u0t4hy8	90	22	and	and	CC
cord-011917-6u0t4hy8	90	23	mortality	mortality	NN
cord-011917-6u0t4hy8	90	24	due	due	IN
cord-011917-6u0t4hy8	90	25	to	to	IN
cord-011917-6u0t4hy8	90	26	the	the	DT
cord-011917-6u0t4hy8	90	27	lack	lack	NN
cord-011917-6u0t4hy8	90	28	of	of	IN
cord-011917-6u0t4hy8	90	29	ferret	ferret	JJ
cord-011917-6u0t4hy8	90	30	immunological	immunological	JJ
cord-011917-6u0t4hy8	90	31	reagents	reagent	NNS
cord-011917-6u0t4hy8	90	32	.	.	.
cord-011917-6u0t4hy8	91	1	From	from	IN
cord-011917-6u0t4hy8	91	2	these	these	DT
cord-011917-6u0t4hy8	91	3	data	datum	NNS
cord-011917-6u0t4hy8	91	4	,	,	,
cord-011917-6u0t4hy8	91	5	an	an	DT
cord-011917-6u0t4hy8	91	6	ideal	ideal	JJ
cord-011917-6u0t4hy8	91	7	state	state	NN
cord-011917-6u0t4hy8	91	8	of	of	IN
cord-011917-6u0t4hy8	91	9	protection	protection	NN
cord-011917-6u0t4hy8	91	10	against	against	IN
cord-011917-6u0t4hy8	91	11	re	re	NN
cord-011917-6u0t4hy8	91	12	-	-	NN
cord-011917-6u0t4hy8	91	13	infection	infection	NN
cord-011917-6u0t4hy8	91	14	of	of	IN
cord-011917-6u0t4hy8	91	15	influenza	influenza	NN
cord-011917-6u0t4hy8	91	16	virus	virus	NN
cord-011917-6u0t4hy8	91	17	was	be	VBD
cord-011917-6u0t4hy8	91	18	defined	define	VBN
cord-011917-6u0t4hy8	91	19	along	along	IN
cord-011917-6u0t4hy8	91	20	with	with	IN
cord-011917-6u0t4hy8	91	21	a	a	DT
cord-011917-6u0t4hy8	91	22	goal	goal	NN
cord-011917-6u0t4hy8	91	23	to	to	TO
cord-011917-6u0t4hy8	91	24	generate	generate	VB
cord-011917-6u0t4hy8	91	25	a	a	DT
cord-011917-6u0t4hy8	91	26	vaccine	vaccine	NN
cord-011917-6u0t4hy8	91	27	that	that	WDT
cord-011917-6u0t4hy8	91	28	will	will	MD
cord-011917-6u0t4hy8	91	29	elicit	elicit	VB
cord-011917-6u0t4hy8	91	30	similar	similar	JJ
cord-011917-6u0t4hy8	91	31	protection	protection	NN
cord-011917-6u0t4hy8	91	32	.	.	.
cord-011917-6u0t4hy8	92	1	Although	although	IN
cord-011917-6u0t4hy8	92	2	not	not	RB
cord-011917-6u0t4hy8	92	3	sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	92	4	,	,	,
cord-011917-6u0t4hy8	92	5	it	-PRON-	PRP
cord-011917-6u0t4hy8	92	6	was	be	VBD
cord-011917-6u0t4hy8	92	7	found	find	VBN
cord-011917-6u0t4hy8	92	8	that	that	IN
cord-011917-6u0t4hy8	92	9	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	92	10	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	92	11	)	)	-RRB-
cord-011917-6u0t4hy8	92	12	pre	pre	JJ
cord-011917-6u0t4hy8	92	13	-	-	JJ
cord-011917-6u0t4hy8	92	14	immune	immune	JJ
cord-011917-6u0t4hy8	92	15	animals	animal	NNS
cord-011917-6u0t4hy8	92	16	exhibited	exhibit	VBD
cord-011917-6u0t4hy8	92	17	immunity	immunity	NN
cord-011917-6u0t4hy8	92	18	and	and	CC
cord-011917-6u0t4hy8	92	19	mitigated	mitigate	VBN
cord-011917-6u0t4hy8	92	20	infection	infection	NN
cord-011917-6u0t4hy8	92	21	against	against	IN
cord-011917-6u0t4hy8	92	22	the	the	DT
cord-011917-6u0t4hy8	92	23	pandemic	pandemic	NN
cord-011917-6u0t4hy8	92	24	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	92	25	)	)	-RRB-
cord-011917-6u0t4hy8	92	26	virus	virus	NN
cord-011917-6u0t4hy8	92	27	[	[	-LRB-
cord-011917-6u0t4hy8	92	28	70	70	CD
cord-011917-6u0t4hy8	92	29	]	]	-RRB-
cord-011917-6u0t4hy8	92	30	.	.	.
cord-011917-6u0t4hy8	93	1	Through	through	IN
cord-011917-6u0t4hy8	93	2	multiple	multiple	JJ
cord-011917-6u0t4hy8	93	3	infection	infection	NN
cord-011917-6u0t4hy8	93	4	and	and	CC
cord-011917-6u0t4hy8	93	5	vaccination	vaccination	NN
cord-011917-6u0t4hy8	93	6	schemes	scheme	NNS
cord-011917-6u0t4hy8	93	7	,	,	,
cord-011917-6u0t4hy8	93	8	vaccination	vaccination	NN
cord-011917-6u0t4hy8	93	9	with	with	IN
cord-011917-6u0t4hy8	93	10	the	the	DT
cord-011917-6u0t4hy8	93	11	trivalent	trivalent	JJ
cord-011917-6u0t4hy8	93	12	influenza	influenza	NN
cord-011917-6u0t4hy8	93	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	93	14	(	(	-LRB-
cord-011917-6u0t4hy8	93	15	TIV	TIV	NNP
cord-011917-6u0t4hy8	93	16	;	;	:
cord-011917-6u0t4hy8	93	17	containing	contain	VBG
cord-011917-6u0t4hy8	93	18	only	only	RB
cord-011917-6u0t4hy8	93	19	one	one	CD
cord-011917-6u0t4hy8	93	20	Type	type	NN
cord-011917-6u0t4hy8	93	21	B	B	NNP
cord-011917-6u0t4hy8	93	22	strain	strain	NN
cord-011917-6u0t4hy8	93	23	instead	instead	RB
cord-011917-6u0t4hy8	93	24	of	of	IN
cord-011917-6u0t4hy8	93	25	two	two	CD
cord-011917-6u0t4hy8	93	26	)	)	-RRB-
cord-011917-6u0t4hy8	93	27	was	be	VBD
cord-011917-6u0t4hy8	93	28	unable	unable	JJ
cord-011917-6u0t4hy8	93	29	to	to	TO
cord-011917-6u0t4hy8	93	30	lessen	lessen	VB
cord-011917-6u0t4hy8	93	31	the	the	DT
cord-011917-6u0t4hy8	93	32	resulting	result	VBG
cord-011917-6u0t4hy8	93	33	morbidity	morbidity	NN
cord-011917-6u0t4hy8	93	34	or	or	CC
cord-011917-6u0t4hy8	93	35	contact	contact	NN
cord-011917-6u0t4hy8	93	36	transmission	transmission	NN
cord-011917-6u0t4hy8	93	37	in	in	IN
cord-011917-6u0t4hy8	93	38	ferrets	ferret	NNS
cord-011917-6u0t4hy8	93	39	following	follow	VBG
cord-011917-6u0t4hy8	93	40	challenge	challenge	NN
cord-011917-6u0t4hy8	93	41	with	with	IN
cord-011917-6u0t4hy8	93	42	the	the	DT
cord-011917-6u0t4hy8	93	43	pandemic	pandemic	NN
cord-011917-6u0t4hy8	93	44	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	93	45	)	)	-RRB-
cord-011917-6u0t4hy8	94	1	[	[	-LRB-
cord-011917-6u0t4hy8	94	2	38	38	CD
cord-011917-6u0t4hy8	94	3	]	]	-RRB-
cord-011917-6u0t4hy8	94	4	.	.	.
cord-011917-6u0t4hy8	95	1	Conversely	conversely	RB
cord-011917-6u0t4hy8	95	2	,	,	,
cord-011917-6u0t4hy8	95	3	imprinting	imprint	VBG
cord-011917-6u0t4hy8	95	4	with	with	IN
cord-011917-6u0t4hy8	95	5	a	a	DT
cord-011917-6u0t4hy8	95	6	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	95	7	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	95	8	)	)	-RRB-
cord-011917-6u0t4hy8	95	9	virus	virus	NN
cord-011917-6u0t4hy8	95	10	altered	alter	VBD
cord-011917-6u0t4hy8	95	11	the	the	DT
cord-011917-6u0t4hy8	95	12	morbidity	morbidity	NN
cord-011917-6u0t4hy8	95	13	,	,	,
cord-011917-6u0t4hy8	95	14	but	but	CC
cord-011917-6u0t4hy8	95	15	not	not	RB
cord-011917-6u0t4hy8	95	16	the	the	DT
cord-011917-6u0t4hy8	95	17	transmission	transmission	NN
cord-011917-6u0t4hy8	95	18	characteristics	characteristic	NNS
cord-011917-6u0t4hy8	95	19	of	of	IN
cord-011917-6u0t4hy8	95	20	the	the	DT
cord-011917-6u0t4hy8	95	21	pandemic	pandemic	NN
cord-011917-6u0t4hy8	95	22	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	95	23	)	)	-RRB-
cord-011917-6u0t4hy8	95	24	[	[	-LRB-
cord-011917-6u0t4hy8	95	25	38	38	CD
cord-011917-6u0t4hy8	95	26	]	]	-RRB-
cord-011917-6u0t4hy8	95	27	.	.	.
cord-011917-6u0t4hy8	96	1	Although	although	IN
cord-011917-6u0t4hy8	96	2	,	,	,
cord-011917-6u0t4hy8	96	3	these	these	DT
cord-011917-6u0t4hy8	96	4	viral	viral	JJ
cord-011917-6u0t4hy8	96	5	traits	trait	NNS
cord-011917-6u0t4hy8	96	6	were	be	VBD
cord-011917-6u0t4hy8	96	7	muted	mute	VBN
cord-011917-6u0t4hy8	96	8	,	,	,
cord-011917-6u0t4hy8	96	9	there	there	EX
cord-011917-6u0t4hy8	96	10	was	be	VBD
cord-011917-6u0t4hy8	96	11	only	only	RB
cord-011917-6u0t4hy8	96	12	minimal	minimal	JJ
cord-011917-6u0t4hy8	96	13	detection	detection	NN
cord-011917-6u0t4hy8	96	14	of	of	IN
cord-011917-6u0t4hy8	96	15	cross	cross	JJ
cord-011917-6u0t4hy8	96	16	-	-	JJ
cord-011917-6u0t4hy8	96	17	reactive	reactive	JJ
cord-011917-6u0t4hy8	96	18	serum	serum	NN
cord-011917-6u0t4hy8	96	19	antibodies	antibody	NNS
cord-011917-6u0t4hy8	96	20	.	.	.
cord-011917-6u0t4hy8	97	1	The	the	DT
cord-011917-6u0t4hy8	97	2	2009	2009	CD
cord-011917-6u0t4hy8	97	3	pandemic	pandemic	NN
cord-011917-6u0t4hy8	97	4	was	be	VBD
cord-011917-6u0t4hy8	97	5	characterized	characterize	VBN
cord-011917-6u0t4hy8	97	6	by	by	IN
cord-011917-6u0t4hy8	97	7	distinct	distinct	JJ
cord-011917-6u0t4hy8	97	8	protective	protective	JJ
cord-011917-6u0t4hy8	97	9	responses	response	NNS
cord-011917-6u0t4hy8	97	10	seen	see	VBN
cord-011917-6u0t4hy8	97	11	between	between	IN
cord-011917-6u0t4hy8	97	12	different	different	JJ
cord-011917-6u0t4hy8	97	13	age	age	NN
cord-011917-6u0t4hy8	97	14	groups	group	NNS
cord-011917-6u0t4hy8	97	15	of	of	IN
cord-011917-6u0t4hy8	97	16	people	people	NNS
cord-011917-6u0t4hy8	97	17	.	.	.
cord-011917-6u0t4hy8	98	1	Older	old	JJR
cord-011917-6u0t4hy8	98	2	adults	adult	NNS
cord-011917-6u0t4hy8	98	3	were	be	VBD
cord-011917-6u0t4hy8	98	4	more	more	RBR
cord-011917-6u0t4hy8	98	5	protected	protect	VBN
cord-011917-6u0t4hy8	98	6	than	than	IN
cord-011917-6u0t4hy8	98	7	young	young	JJ
cord-011917-6u0t4hy8	98	8	adults	adult	NNS
cord-011917-6u0t4hy8	98	9	and	and	CC
cord-011917-6u0t4hy8	98	10	children	child	NNS
cord-011917-6u0t4hy8	98	11	against	against	IN
cord-011917-6u0t4hy8	98	12	the	the	DT
cord-011917-6u0t4hy8	98	13	A(H1N1)/California/07/2009	A(H1N1)/California/07/2009	NNP
cord-011917-6u0t4hy8	98	14	pandemic	pandemic	NN
cord-011917-6u0t4hy8	98	15	virus	virus	NN
cord-011917-6u0t4hy8	98	16	.	.	.
cord-011917-6u0t4hy8	99	1	This	this	DT
cord-011917-6u0t4hy8	99	2	older	old	JJR
cord-011917-6u0t4hy8	99	3	population	population	NN
cord-011917-6u0t4hy8	99	4	was	be	VBD
cord-011917-6u0t4hy8	99	5	captured	capture	VBN
cord-011917-6u0t4hy8	99	6	in	in	IN
cord-011917-6u0t4hy8	99	7	the	the	DT
cord-011917-6u0t4hy8	99	8	pre	pre	JJ
cord-011917-6u0t4hy8	99	9	-	-	JJ
cord-011917-6u0t4hy8	99	10	immune	immune	JJ
cord-011917-6u0t4hy8	99	11	ferret	ferret	NN
cord-011917-6u0t4hy8	99	12	model	model	NN
cord-011917-6u0t4hy8	99	13	by	by	IN
cord-011917-6u0t4hy8	99	14	imprinting	imprint	VBG
cord-011917-6u0t4hy8	99	15	with	with	IN
cord-011917-6u0t4hy8	99	16	historical	historical	JJ
cord-011917-6u0t4hy8	99	17	antigenically	antigenically	RB
cord-011917-6u0t4hy8	99	18	distinct	distinct	JJ
cord-011917-6u0t4hy8	99	19	viruses	virus	NNS
cord-011917-6u0t4hy8	99	20	[	[	-LRB-
cord-011917-6u0t4hy8	99	21	71	71	CD
cord-011917-6u0t4hy8	99	22	]	]	-RRB-
cord-011917-6u0t4hy8	99	23	.	.	.
cord-011917-6u0t4hy8	100	1	The	the	DT
cord-011917-6u0t4hy8	100	2	protective	protective	JJ
cord-011917-6u0t4hy8	100	3	responses	response	NNS
cord-011917-6u0t4hy8	100	4	to	to	IN
cord-011917-6u0t4hy8	100	5	a	a	DT
cord-011917-6u0t4hy8	100	6	pandemic	pandemic	NN
cord-011917-6u0t4hy8	100	7	challenge	challenge	NN
cord-011917-6u0t4hy8	100	8	were	be	VBD
cord-011917-6u0t4hy8	100	9	then	then	RB
cord-011917-6u0t4hy8	100	10	measured	measure	VBN
cord-011917-6u0t4hy8	100	11	.	.	.
cord-011917-6u0t4hy8	101	1	The	the	DT
cord-011917-6u0t4hy8	101	2	historical	historical	JJ
cord-011917-6u0t4hy8	101	3	viruses	virus	NNS
cord-011917-6u0t4hy8	101	4	from	from	IN
cord-011917-6u0t4hy8	101	5	the	the	DT
cord-011917-6u0t4hy8	101	6	1950s	1950	NNS
cord-011917-6u0t4hy8	101	7	and	and	CC
cord-011917-6u0t4hy8	101	8	earlier	early	RBR
cord-011917-6u0t4hy8	101	9	elicited	elicit	VBD
cord-011917-6u0t4hy8	101	10	more	more	JJR
cord-011917-6u0t4hy8	101	11	protective	protective	JJ
cord-011917-6u0t4hy8	101	12	responses	response	NNS
cord-011917-6u0t4hy8	101	13	than	than	IN
cord-011917-6u0t4hy8	101	14	the	the	DT
cord-011917-6u0t4hy8	101	15	naïve	naïve	JJ
cord-011917-6u0t4hy8	101	16	ferrets	ferret	NNS
cord-011917-6u0t4hy8	101	17	[	[	-LRB-
cord-011917-6u0t4hy8	101	18	71	71	CD
cord-011917-6u0t4hy8	101	19	]	]	-RRB-
cord-011917-6u0t4hy8	101	20	.	.	.
cord-011917-6u0t4hy8	102	1	This	this	DT
cord-011917-6u0t4hy8	102	2	corroborated	corroborate	VBD
cord-011917-6u0t4hy8	102	3	the	the	DT
cord-011917-6u0t4hy8	102	4	human	human	JJ
cord-011917-6u0t4hy8	102	5	data	datum	NNS
cord-011917-6u0t4hy8	102	6	that	that	WDT
cord-011917-6u0t4hy8	102	7	the	the	DT
cord-011917-6u0t4hy8	102	8	older	old	JJR
cord-011917-6u0t4hy8	102	9	population	population	NN
cord-011917-6u0t4hy8	102	10	was	be	VBD
cord-011917-6u0t4hy8	102	11	more	more	RBR
cord-011917-6u0t4hy8	102	12	protected	protected	JJ
cord-011917-6u0t4hy8	102	13	than	than	IN
cord-011917-6u0t4hy8	102	14	the	the	DT
cord-011917-6u0t4hy8	102	15	younger	young	JJR
cord-011917-6u0t4hy8	102	16	to	to	IN
cord-011917-6u0t4hy8	102	17	a	a	DT
cord-011917-6u0t4hy8	102	18	pandemic	pandemic	NN
cord-011917-6u0t4hy8	102	19	challenge	challenge	NN
cord-011917-6u0t4hy8	102	20	.	.	.
cord-011917-6u0t4hy8	103	1	Next	next	RB
cord-011917-6u0t4hy8	103	2	,	,	,
cord-011917-6u0t4hy8	103	3	the	the	DT
cord-011917-6u0t4hy8	103	4	effects	effect	NNS
cord-011917-6u0t4hy8	103	5	of	of	IN
cord-011917-6u0t4hy8	103	6	imprinting	imprinting	NN
cord-011917-6u0t4hy8	103	7	on	on	IN
cord-011917-6u0t4hy8	103	8	the	the	DT
cord-011917-6u0t4hy8	103	9	response	response	NN
cord-011917-6u0t4hy8	103	10	to	to	IN
cord-011917-6u0t4hy8	103	11	a	a	DT
cord-011917-6u0t4hy8	103	12	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	103	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	103	14	were	be	VBD
cord-011917-6u0t4hy8	103	15	determined	determine	VBN
cord-011917-6u0t4hy8	103	16	.	.	.
cord-011917-6u0t4hy8	104	1	Ferrets	ferret	NNS
cord-011917-6u0t4hy8	104	2	imprinted	imprint	VBN
cord-011917-6u0t4hy8	104	3	with	with	IN
cord-011917-6u0t4hy8	104	4	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	104	5	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	104	6	)	)	-RRB-
cord-011917-6u0t4hy8	104	7	received	receive	VBD
cord-011917-6u0t4hy8	104	8	a	a	DT
cord-011917-6u0t4hy8	104	9	pandemic	pandemic	NN
cord-011917-6u0t4hy8	104	10	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	104	11	)	)	-RRB-
cord-011917-6u0t4hy8	104	12	vaccine	vaccine	NN
cord-011917-6u0t4hy8	104	13	.	.	.
cord-011917-6u0t4hy8	105	1	This	this	DT
cord-011917-6u0t4hy8	105	2	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	105	3	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	105	4	)	)	-RRB-
cord-011917-6u0t4hy8	105	5	priming	priming	NN
cord-011917-6u0t4hy8	105	6	did	do	VBD
cord-011917-6u0t4hy8	105	7	not	not	RB
cord-011917-6u0t4hy8	105	8	diminish	diminish	VB
cord-011917-6u0t4hy8	105	9	the	the	DT
cord-011917-6u0t4hy8	105	10	antibody	antibody	NN
cord-011917-6u0t4hy8	105	11	response	response	NN
cord-011917-6u0t4hy8	105	12	to	to	IN
cord-011917-6u0t4hy8	105	13	either	either	CC
cord-011917-6u0t4hy8	105	14	infection	infection	NN
cord-011917-6u0t4hy8	105	15	or	or	CC
cord-011917-6u0t4hy8	105	16	vaccination	vaccination	NN
cord-011917-6u0t4hy8	105	17	with	with	IN
cord-011917-6u0t4hy8	105	18	the	the	DT
cord-011917-6u0t4hy8	105	19	pandemic	pandemic	NN
cord-011917-6u0t4hy8	105	20	virus	virus	NN
cord-011917-6u0t4hy8	105	21	[	[	-LRB-
cord-011917-6u0t4hy8	105	22	71	71	CD
cord-011917-6u0t4hy8	105	23	]	]	-RRB-
cord-011917-6u0t4hy8	105	24	.	.	.
cord-011917-6u0t4hy8	106	1	Furthermore	furthermore	RB
cord-011917-6u0t4hy8	106	2	,	,	,
cord-011917-6u0t4hy8	106	3	original	original	JJ
cord-011917-6u0t4hy8	106	4	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	106	5	sin	sin	NN
cord-011917-6u0t4hy8	106	6	was	be	VBD
cord-011917-6u0t4hy8	106	7	not	not	RB
cord-011917-6u0t4hy8	106	8	observed	observe	VBN
cord-011917-6u0t4hy8	106	9	in	in	IN
cord-011917-6u0t4hy8	106	10	the	the	DT
cord-011917-6u0t4hy8	106	11	context	context	NN
cord-011917-6u0t4hy8	106	12	of	of	IN
cord-011917-6u0t4hy8	106	13	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	106	14	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	106	15	)	)	-RRB-
cord-011917-6u0t4hy8	106	16	to	to	IN
cord-011917-6u0t4hy8	106	17	pandemic	pandemic	VB
cord-011917-6u0t4hy8	106	18	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	106	19	)	)	-RRB-
cord-011917-6u0t4hy8	106	20	.	.	.
cord-011917-6u0t4hy8	107	1	Additionally	additionally	RB
cord-011917-6u0t4hy8	107	2	,	,	,
cord-011917-6u0t4hy8	107	3	priming	prime	VBG
cord-011917-6u0t4hy8	107	4	with	with	IN
cord-011917-6u0t4hy8	107	5	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	107	6	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	107	7	)	)	-RRB-
cord-011917-6u0t4hy8	107	8	virus	virus	NN
cord-011917-6u0t4hy8	107	9	provided	provide	VBD
cord-011917-6u0t4hy8	107	10	cross	cross	NN
cord-011917-6u0t4hy8	107	11	-	-	NN
cord-011917-6u0t4hy8	107	12	protection	protection	NN
cord-011917-6u0t4hy8	107	13	against	against	IN
cord-011917-6u0t4hy8	107	14	the	the	DT
cord-011917-6u0t4hy8	107	15	pandemic	pandemic	NN
cord-011917-6u0t4hy8	107	16	virus	virus	NN
cord-011917-6u0t4hy8	107	17	.	.	.
cord-011917-6u0t4hy8	108	1	However	however	RB
cord-011917-6u0t4hy8	108	2	,	,	,
cord-011917-6u0t4hy8	108	3	it	-PRON-	PRP
cord-011917-6u0t4hy8	108	4	did	do	VBD
cord-011917-6u0t4hy8	108	5	not	not	RB
cord-011917-6u0t4hy8	108	6	impact	impact	VB
cord-011917-6u0t4hy8	108	7	the	the	DT
cord-011917-6u0t4hy8	108	8	transmission	transmission	NN
cord-011917-6u0t4hy8	108	9	efficiency	efficiency	NN
cord-011917-6u0t4hy8	108	10	[	[	-LRB-
cord-011917-6u0t4hy8	108	11	72	72	CD
cord-011917-6u0t4hy8	108	12	]	]	-RRB-
cord-011917-6u0t4hy8	108	13	.	.	.
cord-011917-6u0t4hy8	109	1	A	a	DT
cord-011917-6u0t4hy8	109	2	human	human	NN
cord-011917-6u0t4hy8	109	3	's	's	POS
cord-011917-6u0t4hy8	109	4	pre	pre	JJ
cord-011917-6u0t4hy8	109	5	-	-	JJ
cord-011917-6u0t4hy8	109	6	immune	immune	JJ
cord-011917-6u0t4hy8	109	7	history	history	NN
cord-011917-6u0t4hy8	109	8	can	can	MD
cord-011917-6u0t4hy8	109	9	be	be	VB
cord-011917-6u0t4hy8	109	10	recapitulated	recapitulate	VBN
cord-011917-6u0t4hy8	109	11	in	in	IN
cord-011917-6u0t4hy8	109	12	ferrets	ferret	NNS
cord-011917-6u0t4hy8	109	13	by	by	IN
cord-011917-6u0t4hy8	109	14	conducting	conduct	VBG
cord-011917-6u0t4hy8	109	15	repeated	repeat	VBN
cord-011917-6u0t4hy8	109	16	infections	infection	NNS
cord-011917-6u0t4hy8	109	17	.	.	.
cord-011917-6u0t4hy8	110	1	Carter	Carter	NNP
cord-011917-6u0t4hy8	110	2	et	et	NNP
cord-011917-6u0t4hy8	110	3	al	al	NNP
cord-011917-6u0t4hy8	110	4	.	.	.
cord-011917-6u0t4hy8	111	1	[	[	-LRB-
cord-011917-6u0t4hy8	111	2	73	73	CD
cord-011917-6u0t4hy8	111	3	]	]	-RRB-
cord-011917-6u0t4hy8	111	4	utilized	utilize	VBN
cord-011917-6u0t4hy8	111	5	this	this	DT
cord-011917-6u0t4hy8	111	6	technique	technique	NN
cord-011917-6u0t4hy8	111	7	by	by	IN
cord-011917-6u0t4hy8	111	8	sequentially	sequentially	RB
cord-011917-6u0t4hy8	111	9	infecting	infect	VBG
cord-011917-6u0t4hy8	111	10	two	two	CD
cord-011917-6u0t4hy8	111	11	different	different	JJ
cord-011917-6u0t4hy8	111	12	ferret	ferret	NN
cord-011917-6u0t4hy8	111	13	groups	group	NNS
cord-011917-6u0t4hy8	111	14	with	with	IN
cord-011917-6u0t4hy8	111	15	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	111	16	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	111	17	)	)	-RRB-
cord-011917-6u0t4hy8	111	18	:	:	:
cord-011917-6u0t4hy8	112	1	one	one	CD
cord-011917-6u0t4hy8	112	2	with	with	IN
cord-011917-6u0t4hy8	112	3	historical	historical	JJ
cord-011917-6u0t4hy8	112	4	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	112	5	)	)	-RRB-
cord-011917-6u0t4hy8	112	6	from	from	IN
cord-011917-6u0t4hy8	112	7	1934	1934	CD
cord-011917-6u0t4hy8	112	8	to	to	IN
cord-011917-6u0t4hy8	112	9	1957	1957	CD
cord-011917-6u0t4hy8	112	10	,	,	,
cord-011917-6u0t4hy8	112	11	and	and	CC
cord-011917-6u0t4hy8	112	12	another	another	DT
cord-011917-6u0t4hy8	112	13	with	with	IN
cord-011917-6u0t4hy8	112	14	contemporary	contemporary	JJ
cord-011917-6u0t4hy8	112	15	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	112	16	)	)	-RRB-
cord-011917-6u0t4hy8	112	17	viruses	virus	NNS
cord-011917-6u0t4hy8	112	18	from	from	IN
cord-011917-6u0t4hy8	112	19	1999	1999	CD
cord-011917-6u0t4hy8	112	20	to	to	IN
cord-011917-6u0t4hy8	112	21	2007	2007	CD
cord-011917-6u0t4hy8	112	22	.	.	.
cord-011917-6u0t4hy8	113	1	The	the	DT
cord-011917-6u0t4hy8	113	2	abilities	ability	NNS
cord-011917-6u0t4hy8	113	3	of	of	IN
cord-011917-6u0t4hy8	113	4	the	the	DT
cord-011917-6u0t4hy8	113	5	differing	differ	VBG
cord-011917-6u0t4hy8	113	6	pre	pre	JJ
cord-011917-6u0t4hy8	113	7	-	-	NNS
cord-011917-6u0t4hy8	113	8	immunities	immunity	NNS
cord-011917-6u0t4hy8	113	9	to	to	TO
cord-011917-6u0t4hy8	113	10	protect	protect	VB
cord-011917-6u0t4hy8	113	11	against	against	IN
cord-011917-6u0t4hy8	113	12	an	an	DT
cord-011917-6u0t4hy8	113	13	A(H1N1)/California/07/2009	a(h1n1)/california/07/2009	NN
cord-011917-6u0t4hy8	113	14	challenge	challenge	NN
cord-011917-6u0t4hy8	113	15	were	be	VBD
cord-011917-6u0t4hy8	113	16	compared	compare	VBN
cord-011917-6u0t4hy8	113	17	.	.	.
cord-011917-6u0t4hy8	114	1	Both	both	DT
cord-011917-6u0t4hy8	114	2	sequential	sequential	JJ
cord-011917-6u0t4hy8	114	3	groups	group	NNS
cord-011917-6u0t4hy8	114	4	were	be	VBD
cord-011917-6u0t4hy8	114	5	protected	protect	VBN
cord-011917-6u0t4hy8	114	6	from	from	IN
cord-011917-6u0t4hy8	114	7	challenge	challenge	NN
cord-011917-6u0t4hy8	114	8	;	;	:
cord-011917-6u0t4hy8	114	9	they	-PRON-	PRP
cord-011917-6u0t4hy8	114	10	exhibited	exhibit	VBD
cord-011917-6u0t4hy8	114	11	no	no	DT
cord-011917-6u0t4hy8	114	12	weight	weight	NN
cord-011917-6u0t4hy8	114	13	loss	loss	NN
cord-011917-6u0t4hy8	114	14	,	,	,
cord-011917-6u0t4hy8	114	15	minimal	minimal	JJ
cord-011917-6u0t4hy8	114	16	recoverable	recoverable	JJ
cord-011917-6u0t4hy8	114	17	virus	virus	NN
cord-011917-6u0t4hy8	114	18	,	,	,
cord-011917-6u0t4hy8	114	19	and	and	CC
cord-011917-6u0t4hy8	114	20	no	no	DT
cord-011917-6u0t4hy8	114	21	transmission	transmission	NN
cord-011917-6u0t4hy8	114	22	compared	compare	VBN
cord-011917-6u0t4hy8	114	23	to	to	IN
cord-011917-6u0t4hy8	114	24	ferrets	ferret	NNS
cord-011917-6u0t4hy8	114	25	pre	pre	VB
cord-011917-6u0t4hy8	114	26	-	-	VBN
cord-011917-6u0t4hy8	114	27	immunized	immunize	VBN
cord-011917-6u0t4hy8	114	28	with	with	IN
cord-011917-6u0t4hy8	114	29	only	only	RB
cord-011917-6u0t4hy8	114	30	one	one	CD
cord-011917-6u0t4hy8	114	31	of	of	IN
cord-011917-6u0t4hy8	114	32	the	the	DT
cord-011917-6u0t4hy8	114	33	viruses	virus	NNS
cord-011917-6u0t4hy8	114	34	.	.	.
cord-011917-6u0t4hy8	115	1	Unique	unique	JJ
cord-011917-6u0t4hy8	115	2	to	to	IN
cord-011917-6u0t4hy8	115	3	sequentially	sequentially	RB
cord-011917-6u0t4hy8	115	4	infected	infect	VBN
cord-011917-6u0t4hy8	115	5	ferrets	ferret	NNS
cord-011917-6u0t4hy8	115	6	,	,	,
cord-011917-6u0t4hy8	115	7	the	the	DT
cord-011917-6u0t4hy8	115	8	elicited	elicit	VBN
cord-011917-6u0t4hy8	115	9	antibody	antibody	NN
cord-011917-6u0t4hy8	115	10	profile	profile	NN
cord-011917-6u0t4hy8	115	11	was	be	VBD
cord-011917-6u0t4hy8	115	12	broader	broad	JJR
cord-011917-6u0t4hy8	115	13	and	and	CC
cord-011917-6u0t4hy8	115	14	interacted	interact	VBN
cord-011917-6u0t4hy8	115	15	with	with	IN
cord-011917-6u0t4hy8	115	16	pandemic	pandemic	NN
cord-011917-6u0t4hy8	115	17	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	115	18	)	)	-RRB-
cord-011917-6u0t4hy8	116	1	HA	HA	NNP
cord-011917-6u0t4hy8	117	1	compared	compare	VBN
cord-011917-6u0t4hy8	117	2	to	to	IN
cord-011917-6u0t4hy8	117	3	the	the	DT
cord-011917-6u0t4hy8	117	4	single	single	JJ
cord-011917-6u0t4hy8	117	5	pre	pre	JJ
cord-011917-6u0t4hy8	117	6	-	-	JJ
cord-011917-6u0t4hy8	117	7	immunity	immunity	JJ
cord-011917-6u0t4hy8	117	8	groups	group	NNS
cord-011917-6u0t4hy8	117	9	as	as	IN
cord-011917-6u0t4hy8	117	10	measured	measure	VBN
cord-011917-6u0t4hy8	117	11	with	with	IN
cord-011917-6u0t4hy8	117	12	HA	HA	NNP
cord-011917-6u0t4hy8	117	13	-	-	HYPH
cord-011917-6u0t4hy8	117	14	specific	specific	JJ
cord-011917-6u0t4hy8	117	15	ELISA	ELISA	NNP
cord-011917-6u0t4hy8	117	16	binding	binding	NN
cord-011917-6u0t4hy8	117	17	.	.	.
cord-011917-6u0t4hy8	118	1	The	the	DT
cord-011917-6u0t4hy8	118	2	recall	recall	NN
cord-011917-6u0t4hy8	118	3	and	and	CC
cord-011917-6u0t4hy8	118	4	adaptation	adaptation	NN
cord-011917-6u0t4hy8	118	5	of	of	IN
cord-011917-6u0t4hy8	118	6	the	the	DT
cord-011917-6u0t4hy8	118	7	antibody	antibody	NN
cord-011917-6u0t4hy8	118	8	profile	profile	NN
cord-011917-6u0t4hy8	118	9	over	over	IN
cord-011917-6u0t4hy8	118	10	time	time	NN
cord-011917-6u0t4hy8	118	11	in	in	IN
cord-011917-6u0t4hy8	118	12	response	response	NN
cord-011917-6u0t4hy8	118	13	to	to	IN
cord-011917-6u0t4hy8	118	14	sequential	sequential	JJ
cord-011917-6u0t4hy8	118	15	exposures	exposure	NNS
cord-011917-6u0t4hy8	118	16	is	be	VBZ
cord-011917-6u0t4hy8	118	17	complex	complex	JJ
cord-011917-6u0t4hy8	118	18	and	and	CC
cord-011917-6u0t4hy8	118	19	still	still	RB
cord-011917-6u0t4hy8	118	20	not	not	RB
cord-011917-6u0t4hy8	118	21	completely	completely	RB
cord-011917-6u0t4hy8	118	22	understood	understand	VBN
cord-011917-6u0t4hy8	118	23	.	.	.
cord-011917-6u0t4hy8	119	1	However	however	RB
cord-011917-6u0t4hy8	119	2	,	,	,
cord-011917-6u0t4hy8	119	3	these	these	DT
cord-011917-6u0t4hy8	119	4	interactions	interaction	NNS
cord-011917-6u0t4hy8	119	5	help	help	VBP
cord-011917-6u0t4hy8	119	6	to	to	TO
cord-011917-6u0t4hy8	119	7	explain	explain	VB
cord-011917-6u0t4hy8	119	8	the	the	DT
cord-011917-6u0t4hy8	119	9	puzzling	puzzle	VBG
cord-011917-6u0t4hy8	119	10	epidemiological	epidemiological	JJ
cord-011917-6u0t4hy8	119	11	and	and	CC
cord-011917-6u0t4hy8	119	12	serological	serological	JJ
cord-011917-6u0t4hy8	119	13	observations	observation	NNS
cord-011917-6u0t4hy8	119	14	surrounding	surround	VBG
cord-011917-6u0t4hy8	119	15	the	the	DT
cord-011917-6u0t4hy8	119	16	pandemic	pandemic	NN
cord-011917-6u0t4hy8	119	17	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	119	18	)	)	-RRB-
cord-011917-6u0t4hy8	119	19	outbreak	outbreak	NN
cord-011917-6u0t4hy8	119	20	.	.	.
cord-011917-6u0t4hy8	120	1	Carter	Carter	NNP
cord-011917-6u0t4hy8	120	2	et	et	NNP
cord-011917-6u0t4hy8	120	3	al	al	NNP
cord-011917-6u0t4hy8	120	4	.	.	.
cord-011917-6u0t4hy8	121	1	[	[	-LRB-
cord-011917-6u0t4hy8	121	2	73	73	CD
cord-011917-6u0t4hy8	121	3	]	]	-RRB-
cord-011917-6u0t4hy8	121	4	hypothesized	hypothesize	VBD
cord-011917-6u0t4hy8	121	5	that	that	IN
cord-011917-6u0t4hy8	121	6	the	the	DT
cord-011917-6u0t4hy8	121	7	older	old	JJR
cord-011917-6u0t4hy8	121	8	adults	adult	NNS
cord-011917-6u0t4hy8	121	9	were	be	VBD
cord-011917-6u0t4hy8	121	10	exposed	expose	VBN
cord-011917-6u0t4hy8	121	11	to	to	IN
cord-011917-6u0t4hy8	121	12	more	more	JJR
cord-011917-6u0t4hy8	121	13	antigenically	antigenically	NN
cord-011917-6u0t4hy8	121	14	variant	variant	JJ
cord-011917-6u0t4hy8	121	15	strains	strain	NNS
cord-011917-6u0t4hy8	121	16	and	and	CC
cord-011917-6u0t4hy8	121	17	have	have	VBP
cord-011917-6u0t4hy8	121	18	extensive	extensive	JJ
cord-011917-6u0t4hy8	121	19	protection	protection	NN
cord-011917-6u0t4hy8	121	20	compared	compare	VBN
cord-011917-6u0t4hy8	121	21	to	to	IN
cord-011917-6u0t4hy8	121	22	young	young	JJ
cord-011917-6u0t4hy8	121	23	adults	adult	NNS
cord-011917-6u0t4hy8	121	24	with	with	IN
cord-011917-6u0t4hy8	121	25	less	less	JJR
cord-011917-6u0t4hy8	121	26	exposure	exposure	NN
cord-011917-6u0t4hy8	121	27	.	.	.
cord-011917-6u0t4hy8	122	1	In	in	IN
cord-011917-6u0t4hy8	122	2	addition	addition	NN
cord-011917-6u0t4hy8	122	3	,	,	,
cord-011917-6u0t4hy8	122	4	the	the	DT
cord-011917-6u0t4hy8	122	5	changes	change	NNS
cord-011917-6u0t4hy8	122	6	in	in	IN
cord-011917-6u0t4hy8	122	7	the	the	DT
cord-011917-6u0t4hy8	122	8	elicited	elicit	VBN
cord-011917-6u0t4hy8	122	9	antibody	antibody	NN
cord-011917-6u0t4hy8	122	10	profile	profile	NN
cord-011917-6u0t4hy8	122	11	point	point	NN
cord-011917-6u0t4hy8	122	12	to	to	IN
cord-011917-6u0t4hy8	122	13	the	the	DT
cord-011917-6u0t4hy8	122	14	possibility	possibility	NN
cord-011917-6u0t4hy8	122	15	of	of	IN
cord-011917-6u0t4hy8	122	16	achieving	achieve	VBG
cord-011917-6u0t4hy8	122	17	broad	broad	JJ
cord-011917-6u0t4hy8	122	18	vaccine	vaccine	NN
cord-011917-6u0t4hy8	122	19	-	-	HYPH
cord-011917-6u0t4hy8	122	20	induced	induce	VBN
cord-011917-6u0t4hy8	122	21	protection	protection	NN
cord-011917-6u0t4hy8	122	22	against	against	IN
cord-011917-6u0t4hy8	122	23	influenza	influenza	NN
cord-011917-6u0t4hy8	122	24	viruses	virus	NNS
cord-011917-6u0t4hy8	122	25	by	by	IN
cord-011917-6u0t4hy8	122	26	sequential	sequential	JJ
cord-011917-6u0t4hy8	122	27	immunization	immunization	NN
cord-011917-6u0t4hy8	122	28	with	with	IN
cord-011917-6u0t4hy8	122	29	a	a	DT
cord-011917-6u0t4hy8	122	30	series	series	NN
cord-011917-6u0t4hy8	122	31	of	of	IN
cord-011917-6u0t4hy8	122	32	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	122	33	variants	variant	NNS
cord-011917-6u0t4hy8	122	34	.	.	.
cord-011917-6u0t4hy8	123	1	Further	further	JJ
cord-011917-6u0t4hy8	123	2	analysis	analysis	NN
cord-011917-6u0t4hy8	123	3	with	with	IN
cord-011917-6u0t4hy8	123	4	these	these	DT
cord-011917-6u0t4hy8	123	5	ferret	ferret	NN
cord-011917-6u0t4hy8	123	6	samples	sample	NNS
cord-011917-6u0t4hy8	123	7	and	and	CC
cord-011917-6u0t4hy8	123	8	infection	infection	NN
cord-011917-6u0t4hy8	123	9	/	/	SYM
cord-011917-6u0t4hy8	123	10	immunization	immunization	NN
cord-011917-6u0t4hy8	123	11	scheme	scheme	NN
cord-011917-6u0t4hy8	123	12	confirmed	confirm	VBD
cord-011917-6u0t4hy8	123	13	the	the	DT
cord-011917-6u0t4hy8	123	14	change	change	NN
cord-011917-6u0t4hy8	123	15	in	in	IN
cord-011917-6u0t4hy8	123	16	antibody	antibody	NN
cord-011917-6u0t4hy8	123	17	profile	profile	NN
cord-011917-6u0t4hy8	123	18	observed	observe	VBD
cord-011917-6u0t4hy8	123	19	previously	previously	RB
cord-011917-6u0t4hy8	123	20	.	.	.
cord-011917-6u0t4hy8	124	1	Anti	Anti	NNP
cord-011917-6u0t4hy8	124	2	-	-	NNP
cord-011917-6u0t4hy8	124	3	HA	HA	NNP
cord-011917-6u0t4hy8	124	4	stalk	stalk	NN
cord-011917-6u0t4hy8	124	5	antibodies	antibody	NNS
cord-011917-6u0t4hy8	124	6	increased	increase	VBD
cord-011917-6u0t4hy8	124	7	,	,	,
cord-011917-6u0t4hy8	124	8	even	even	RB
cord-011917-6u0t4hy8	124	9	in	in	IN
cord-011917-6u0t4hy8	124	10	the	the	DT
cord-011917-6u0t4hy8	124	11	absence	absence	NN
cord-011917-6u0t4hy8	124	12	of	of	IN
cord-011917-6u0t4hy8	124	13	receptor	receptor	NN
cord-011917-6u0t4hy8	124	14	-	-	HYPH
cord-011917-6u0t4hy8	124	15	binding	bind	VBG
cord-011917-6u0t4hy8	124	16	site	site	NN
cord-011917-6u0t4hy8	124	17	antibodies	antibody	NNS
cord-011917-6u0t4hy8	124	18	,	,	,
cord-011917-6u0t4hy8	124	19	leading	lead	VBG
cord-011917-6u0t4hy8	124	20	to	to	IN
cord-011917-6u0t4hy8	124	21	the	the	DT
cord-011917-6u0t4hy8	124	22	observed	observed	JJ
cord-011917-6u0t4hy8	124	23	cross	cross	NN
cord-011917-6u0t4hy8	124	24	-	-	NN
cord-011917-6u0t4hy8	124	25	reactivity	reactivity	NN
cord-011917-6u0t4hy8	124	26	and	and	CC
cord-011917-6u0t4hy8	124	27	reduction	reduction	NN
cord-011917-6u0t4hy8	124	28	in	in	IN
cord-011917-6u0t4hy8	124	29	clinical	clinical	JJ
cord-011917-6u0t4hy8	124	30	signs	sign	NNS
cord-011917-6u0t4hy8	124	31	and	and	CC
cord-011917-6u0t4hy8	124	32	transmission	transmission	NN
cord-011917-6u0t4hy8	124	33	[	[	-LRB-
cord-011917-6u0t4hy8	124	34	74	74	CD
cord-011917-6u0t4hy8	124	35	]	]	-RRB-
cord-011917-6u0t4hy8	124	36	.	.	.
cord-011917-6u0t4hy8	125	1	In	in	IN
cord-011917-6u0t4hy8	125	2	contrast	contrast	NN
cord-011917-6u0t4hy8	125	3	to	to	IN
cord-011917-6u0t4hy8	125	4	previous	previous	JJ
cord-011917-6u0t4hy8	125	5	reports	report	NNS
cord-011917-6u0t4hy8	125	6	that	that	IN
cord-011917-6u0t4hy8	125	7	pre	pre	JJ
cord-011917-6u0t4hy8	125	8	-	-	JJ
cord-011917-6u0t4hy8	125	9	immunity	immunity	JJ
cord-011917-6u0t4hy8	125	10	induced	induce	VBN
cord-011917-6u0t4hy8	125	11	protection	protection	NN
cord-011917-6u0t4hy8	125	12	does	do	VBZ
cord-011917-6u0t4hy8	125	13	not	not	RB
cord-011917-6u0t4hy8	125	14	wane	wane	VB
cord-011917-6u0t4hy8	125	15	[	[	-LRB-
cord-011917-6u0t4hy8	125	16	68	68	CD
cord-011917-6u0t4hy8	125	17	]	]	-RRB-
cord-011917-6u0t4hy8	125	18	,	,	,
cord-011917-6u0t4hy8	125	19	the	the	DT
cord-011917-6u0t4hy8	125	20	boosts	boost	NNS
cord-011917-6u0t4hy8	125	21	in	in	IN
cord-011917-6u0t4hy8	125	22	anti	anti	JJ
cord-011917-6u0t4hy8	125	23	-	-	JJ
cord-011917-6u0t4hy8	125	24	HA	HA	NNP
cord-011917-6u0t4hy8	125	25	stalk	stalk	VB
cord-011917-6u0t4hy8	125	26	antibodies	antibody	NNS
cord-011917-6u0t4hy8	125	27	and	and	CC
cord-011917-6u0t4hy8	125	28	the	the	DT
cord-011917-6u0t4hy8	125	29	cross	cross	NN
cord-011917-6u0t4hy8	125	30	-	-	NN
cord-011917-6u0t4hy8	125	31	reactivity	reactivity	NN
cord-011917-6u0t4hy8	125	32	induced	induce	VBN
cord-011917-6u0t4hy8	125	33	from	from	IN
cord-011917-6u0t4hy8	125	34	sequential	sequential	JJ
cord-011917-6u0t4hy8	125	35	infection	infection	NN
cord-011917-6u0t4hy8	125	36	with	with	IN
cord-011917-6u0t4hy8	125	37	antigenically	antigenically	RB
cord-011917-6u0t4hy8	125	38	distinct	distinct	JJ
cord-011917-6u0t4hy8	125	39	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	125	40	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	125	41	)	)	-RRB-
cord-011917-6u0t4hy8	125	42	declined	decline	VBD
cord-011917-6u0t4hy8	125	43	over	over	IN
cord-011917-6u0t4hy8	125	44	time	time	NN
cord-011917-6u0t4hy8	125	45	[	[	-LRB-
cord-011917-6u0t4hy8	125	46	74	74	CD
cord-011917-6u0t4hy8	125	47	]	]	-RRB-
cord-011917-6u0t4hy8	125	48	.	.	.
cord-011917-6u0t4hy8	126	1	The	the	DT
cord-011917-6u0t4hy8	126	2	pandemic	pandemic	NN
cord-011917-6u0t4hy8	126	3	outbreak	outbreak	NN
cord-011917-6u0t4hy8	126	4	occurred	occur	VBD
cord-011917-6u0t4hy8	126	5	from	from	IN
cord-011917-6u0t4hy8	126	6	a	a	DT
cord-011917-6u0t4hy8	126	7	transmission	transmission	NN
cord-011917-6u0t4hy8	126	8	event	event	NN
cord-011917-6u0t4hy8	126	9	of	of	IN
cord-011917-6u0t4hy8	126	10	an	an	DT
cord-011917-6u0t4hy8	126	11	avian	avian	JJ
cord-011917-6u0t4hy8	126	12	-	-	HYPH
cord-011917-6u0t4hy8	126	13	human	human	JJ
cord-011917-6u0t4hy8	126	14	-	-	HYPH
cord-011917-6u0t4hy8	126	15	swine	swine	NN
cord-011917-6u0t4hy8	126	16	reassortant	reassortant	JJ
cord-011917-6u0t4hy8	126	17	virus	virus	NN
cord-011917-6u0t4hy8	126	18	from	from	IN
cord-011917-6u0t4hy8	126	19	a	a	DT
cord-011917-6u0t4hy8	126	20	swine	swine	NN
cord-011917-6u0t4hy8	126	21	host	host	NN
cord-011917-6u0t4hy8	126	22	into	into	IN
cord-011917-6u0t4hy8	126	23	the	the	DT
cord-011917-6u0t4hy8	126	24	human	human	JJ
cord-011917-6u0t4hy8	126	25	population	population	NN
cord-011917-6u0t4hy8	126	26	[	[	-LRB-
cord-011917-6u0t4hy8	126	27	75	75	CD
cord-011917-6u0t4hy8	126	28	]	]	-RRB-
cord-011917-6u0t4hy8	126	29	.	.	.
cord-011917-6u0t4hy8	127	1	Whereas	whereas	IN
cord-011917-6u0t4hy8	127	2	many	many	JJ
cord-011917-6u0t4hy8	127	3	groups	group	NNS
cord-011917-6u0t4hy8	127	4	investigated	investigate	VBD
cord-011917-6u0t4hy8	127	5	the	the	DT
cord-011917-6u0t4hy8	127	6	effects	effect	NNS
cord-011917-6u0t4hy8	127	7	of	of	IN
cord-011917-6u0t4hy8	127	8	human	human	JJ
cord-011917-6u0t4hy8	127	9	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	127	10	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	127	11	)	)	-RRB-
cord-011917-6u0t4hy8	127	12	imprinting	imprinting	NN
cord-011917-6u0t4hy8	127	13	,	,	,
cord-011917-6u0t4hy8	127	14	the	the	DT
cord-011917-6u0t4hy8	127	15	effects	effect	NNS
cord-011917-6u0t4hy8	127	16	of	of	IN
cord-011917-6u0t4hy8	127	17	imprinting	imprinting	NN
cord-011917-6u0t4hy8	127	18	with	with	IN
cord-011917-6u0t4hy8	127	19	a	a	DT
cord-011917-6u0t4hy8	127	20	classical	classical	JJ
cord-011917-6u0t4hy8	127	21	swine	swine	NN
cord-011917-6u0t4hy8	127	22	virus	virus	NN
cord-011917-6u0t4hy8	127	23	were	be	VBD
cord-011917-6u0t4hy8	127	24	also	also	RB
cord-011917-6u0t4hy8	127	25	determined	determine	VBN
cord-011917-6u0t4hy8	127	26	.	.	.
cord-011917-6u0t4hy8	128	1	Min	Min	NNP
cord-011917-6u0t4hy8	128	2	et	et	FW
cord-011917-6u0t4hy8	128	3	al	al	NNP
cord-011917-6u0t4hy8	128	4	.	.	.
cord-011917-6u0t4hy8	129	1	[	[	-LRB-
cord-011917-6u0t4hy8	129	2	76	76	CD
cord-011917-6u0t4hy8	129	3	]	]	-RRB-
cord-011917-6u0t4hy8	129	4	exhibited	exhibit	VBD
cord-011917-6u0t4hy8	129	5	that	that	IN
cord-011917-6u0t4hy8	129	6	infection	infection	NN
cord-011917-6u0t4hy8	129	7	with	with	IN
cord-011917-6u0t4hy8	129	8	classical	classical	JJ
cord-011917-6u0t4hy8	129	9	swine	swine	NN
cord-011917-6u0t4hy8	129	10	viruses	virus	NNS
cord-011917-6u0t4hy8	129	11	elicited	elicit	VBD
cord-011917-6u0t4hy8	129	12	cross	cross	JJ
cord-011917-6u0t4hy8	129	13	-	-	JJ
cord-011917-6u0t4hy8	129	14	reactive	reactive	JJ
cord-011917-6u0t4hy8	129	15	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	129	16	antibody	antibody	NN
cord-011917-6u0t4hy8	129	17	activity	activity	NN
cord-011917-6u0t4hy8	129	18	and	and	CC
cord-011917-6u0t4hy8	129	19	provided	provide	VBD
cord-011917-6u0t4hy8	129	20	protection	protection	NN
cord-011917-6u0t4hy8	129	21	against	against	IN
cord-011917-6u0t4hy8	129	22	the	the	DT
cord-011917-6u0t4hy8	129	23	pandemic	pandemic	NN
cord-011917-6u0t4hy8	129	24	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	129	25	)	)	-RRB-
cord-011917-6u0t4hy8	129	26	virus	virus	NN
cord-011917-6u0t4hy8	129	27	.	.	.
cord-011917-6u0t4hy8	130	1	Over	over	IN
cord-011917-6u0t4hy8	130	2	time	time	NN
cord-011917-6u0t4hy8	130	3	,	,	,
cord-011917-6u0t4hy8	130	4	a	a	DT
cord-011917-6u0t4hy8	130	5	natural	natural	JJ
cord-011917-6u0t4hy8	130	6	break	break	NN
cord-011917-6u0t4hy8	130	7	point	point	NN
cord-011917-6u0t4hy8	130	8	occurred	occur	VBD
cord-011917-6u0t4hy8	130	9	between	between	IN
cord-011917-6u0t4hy8	130	10	the	the	DT
cord-011917-6u0t4hy8	130	11	investigation	investigation	NN
cord-011917-6u0t4hy8	130	12	into	into	IN
cord-011917-6u0t4hy8	130	13	the	the	DT
cord-011917-6u0t4hy8	130	14	pandemic	pandemic	NN
cord-011917-6u0t4hy8	130	15	mystery	mystery	NN
cord-011917-6u0t4hy8	130	16	and	and	CC
cord-011917-6u0t4hy8	130	17	the	the	DT
cord-011917-6u0t4hy8	130	18	examination	examination	NN
cord-011917-6u0t4hy8	130	19	of	of	IN
cord-011917-6u0t4hy8	130	20	the	the	DT
cord-011917-6u0t4hy8	130	21	immune	immune	JJ
cord-011917-6u0t4hy8	130	22	system	system	NN
cord-011917-6u0t4hy8	130	23	response	response	NN
cord-011917-6u0t4hy8	130	24	within	within	IN
cord-011917-6u0t4hy8	130	25	the	the	DT
cord-011917-6u0t4hy8	130	26	context	context	NN
cord-011917-6u0t4hy8	130	27	of	of	IN
cord-011917-6u0t4hy8	130	28	imprinting	imprinting	NN
cord-011917-6u0t4hy8	130	29	and	and	CC
cord-011917-6u0t4hy8	130	30	pre	pre	JJ
cord-011917-6u0t4hy8	130	31	-	-	NN
cord-011917-6u0t4hy8	130	32	immunity	immunity	NN
cord-011917-6u0t4hy8	130	33	.	.	.
cord-011917-6u0t4hy8	131	1	Within	within	IN
cord-011917-6u0t4hy8	131	2	a	a	DT
cord-011917-6u0t4hy8	131	3	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	131	4	and	and	CC
cord-011917-6u0t4hy8	131	5	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	131	6	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	131	7	)	)	-RRB-
cord-011917-6u0t4hy8	132	1	sequential	sequential	JJ
cord-011917-6u0t4hy8	132	2	infection	infection	NN
cord-011917-6u0t4hy8	132	3	study	study	NN
cord-011917-6u0t4hy8	132	4	,	,	,
cord-011917-6u0t4hy8	132	5	the	the	DT
cord-011917-6u0t4hy8	132	6	changes	change	NNS
cord-011917-6u0t4hy8	132	7	in	in	IN
cord-011917-6u0t4hy8	132	8	polyclonal	polyclonal	JJ
cord-011917-6u0t4hy8	132	9	serum	serum	NN
cord-011917-6u0t4hy8	132	10	antibodies	antibody	NNS
cord-011917-6u0t4hy8	132	11	responses	response	NNS
cord-011917-6u0t4hy8	132	12	were	be	VBD
cord-011917-6u0t4hy8	132	13	measured	measure	VBN
cord-011917-6u0t4hy8	132	14	.	.	.
cord-011917-6u0t4hy8	133	1	Ferrets	ferret	NNS
cord-011917-6u0t4hy8	133	2	pre	pre	VBP
cord-011917-6u0t4hy8	133	3	-	-	VBD
cord-011917-6u0t4hy8	133	4	immunized	immunize	VBN
cord-011917-6u0t4hy8	133	5	with	with	IN
cord-011917-6u0t4hy8	133	6	the	the	DT
cord-011917-6u0t4hy8	133	7	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	133	8	A(H1N1)/Texas/36/1991	a(h1n1)/texas/36/1991	NN
cord-011917-6u0t4hy8	133	9	were	be	VBD
cord-011917-6u0t4hy8	133	10	followed	follow	VBN
cord-011917-6u0t4hy8	133	11	up	up	RP
cord-011917-6u0t4hy8	133	12	with	with	IN
cord-011917-6u0t4hy8	133	13	an	an	DT
cord-011917-6u0t4hy8	133	14	A(H1N1)/California/07/2009	a(h1n1)/california/07/2009	NN
cord-011917-6u0t4hy8	133	15	infection	infection	NN
cord-011917-6u0t4hy8	133	16	.	.	.
cord-011917-6u0t4hy8	134	1	The	the	DT
cord-011917-6u0t4hy8	134	2	elicited	elicit	VBN
cord-011917-6u0t4hy8	134	3	serum	serum	NN
cord-011917-6u0t4hy8	134	4	antibody	antibody	NN
cord-011917-6u0t4hy8	134	5	specificity	specificity	NN
cord-011917-6u0t4hy8	134	6	shifted	shift	VBD
cord-011917-6u0t4hy8	134	7	to	to	TO
cord-011917-6u0t4hy8	134	8	target	target	VB
cord-011917-6u0t4hy8	134	9	a	a	DT
cord-011917-6u0t4hy8	134	10	different	different	JJ
cord-011917-6u0t4hy8	134	11	region	region	NN
cord-011917-6u0t4hy8	134	12	of	of	IN
cord-011917-6u0t4hy8	134	13	the	the	DT
cord-011917-6u0t4hy8	134	14	HA	HA	NNP
cord-011917-6u0t4hy8	134	15	compared	compare	VBN
cord-011917-6u0t4hy8	134	16	to	to	IN
cord-011917-6u0t4hy8	134	17	the	the	DT
cord-011917-6u0t4hy8	134	18	A(H1N1)/Texas/36/1991	a(h1n1)/texas/36/1991	NN
cord-011917-6u0t4hy8	134	19	only	only	RB
cord-011917-6u0t4hy8	134	20	serum	serum	NN
cord-011917-6u0t4hy8	134	21	[	[	-LRB-
cord-011917-6u0t4hy8	134	22	77	77	CD
cord-011917-6u0t4hy8	134	23	]	]	-RRB-
cord-011917-6u0t4hy8	134	24	.	.	.
cord-011917-6u0t4hy8	135	1	The	the	DT
cord-011917-6u0t4hy8	135	2	overall	overall	JJ
cord-011917-6u0t4hy8	135	3	antibody	antibody	NN
cord-011917-6u0t4hy8	135	4	response	response	NN
cord-011917-6u0t4hy8	135	5	moved	move	VBD
cord-011917-6u0t4hy8	135	6	to	to	IN
cord-011917-6u0t4hy8	135	7	epitopes	epitope	NNS
cord-011917-6u0t4hy8	135	8	near	near	IN
cord-011917-6u0t4hy8	135	9	the	the	DT
cord-011917-6u0t4hy8	135	10	HA	HA	NNP
cord-011917-6u0t4hy8	135	11	receptor	receptor	NN
cord-011917-6u0t4hy8	135	12	-	-	HYPH
cord-011917-6u0t4hy8	135	13	binding	bind	VBG
cord-011917-6u0t4hy8	135	14	domain	domain	NN
cord-011917-6u0t4hy8	135	15	;	;	:
cord-011917-6u0t4hy8	135	16	sites	site	NNS
cord-011917-6u0t4hy8	135	17	where	where	WRB
cord-011917-6u0t4hy8	135	18	homology	homology	NN
cord-011917-6u0t4hy8	135	19	between	between	IN
cord-011917-6u0t4hy8	135	20	these	these	DT
cord-011917-6u0t4hy8	135	21	two	two	CD
cord-011917-6u0t4hy8	135	22	strains	strain	NNS
cord-011917-6u0t4hy8	135	23	is	be	VBZ
cord-011917-6u0t4hy8	135	24	shared	share	VBN
cord-011917-6u0t4hy8	135	25	[	[	-LRB-
cord-011917-6u0t4hy8	135	26	77	77	CD
cord-011917-6u0t4hy8	135	27	]	]	-RRB-
cord-011917-6u0t4hy8	135	28	.	.	.
cord-011917-6u0t4hy8	136	1	These	these	DT
cord-011917-6u0t4hy8	136	2	findings	finding	NNS
cord-011917-6u0t4hy8	136	3	resulted	result	VBD
cord-011917-6u0t4hy8	136	4	in	in	IN
cord-011917-6u0t4hy8	136	5	research	research	NN
cord-011917-6u0t4hy8	136	6	in	in	IN
cord-011917-6u0t4hy8	136	7	the	the	DT
cord-011917-6u0t4hy8	136	8	basic	basic	JJ
cord-011917-6u0t4hy8	136	9	science	science	NN
cord-011917-6u0t4hy8	136	10	of	of	IN
cord-011917-6u0t4hy8	136	11	how	how	WRB
cord-011917-6u0t4hy8	136	12	imprinting	imprinting	NN
cord-011917-6u0t4hy8	136	13	and	and	CC
cord-011917-6u0t4hy8	136	14	pre	pre	JJ
cord-011917-6u0t4hy8	136	15	-	-	JJ
cord-011917-6u0t4hy8	136	16	immunity	immunity	JJ
cord-011917-6u0t4hy8	136	17	affects	affect	VBZ
cord-011917-6u0t4hy8	136	18	vaccination	vaccination	NN
cord-011917-6u0t4hy8	136	19	and	and	CC
cord-011917-6u0t4hy8	136	20	infection	infection	NN
cord-011917-6u0t4hy8	136	21	and	and	CC
cord-011917-6u0t4hy8	136	22	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	136	23	immune	immune	JJ
cord-011917-6u0t4hy8	136	24	responses	response	NNS
cord-011917-6u0t4hy8	136	25	.	.	.
cord-011917-6u0t4hy8	137	1	The	the	DT
cord-011917-6u0t4hy8	137	2	current	current	JJ
cord-011917-6u0t4hy8	137	3	pre	pre	JJ
cord-011917-6u0t4hy8	137	4	-	-	JJ
cord-011917-6u0t4hy8	137	5	immunity	immunity	JJ
cord-011917-6u0t4hy8	137	6	models	model	NNS
cord-011917-6u0t4hy8	137	7	are	be	VBP
cord-011917-6u0t4hy8	137	8	moving	move	VBG
cord-011917-6u0t4hy8	137	9	away	away	RB
cord-011917-6u0t4hy8	137	10	from	from	IN
cord-011917-6u0t4hy8	137	11	investigating	investigate	VBG
cord-011917-6u0t4hy8	137	12	the	the	DT
cord-011917-6u0t4hy8	137	13	differences	difference	NNS
cord-011917-6u0t4hy8	137	14	in	in	IN
cord-011917-6u0t4hy8	137	15	disease	disease	NN
cord-011917-6u0t4hy8	137	16	symptoms	symptom	NNS
cord-011917-6u0t4hy8	137	17	and	and	CC
cord-011917-6u0t4hy8	137	18	vaccine	vaccine	NN
cord-011917-6u0t4hy8	137	19	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	137	20	observed	observe	VBN
cord-011917-6u0t4hy8	137	21	in	in	IN
cord-011917-6u0t4hy8	137	22	the	the	DT
cord-011917-6u0t4hy8	137	23	human	human	JJ
cord-011917-6u0t4hy8	137	24	population	population	NN
cord-011917-6u0t4hy8	137	25	in	in	IN
cord-011917-6u0t4hy8	137	26	response	response	NN
cord-011917-6u0t4hy8	137	27	to	to	IN
cord-011917-6u0t4hy8	137	28	the	the	DT
cord-011917-6u0t4hy8	137	29	pandemic	pandemic	NN
cord-011917-6u0t4hy8	137	30	virus	virus	NN
cord-011917-6u0t4hy8	137	31	.	.	.
cord-011917-6u0t4hy8	138	1	Resources	resource	NNS
cord-011917-6u0t4hy8	138	2	are	be	VBP
cord-011917-6u0t4hy8	138	3	now	now	RB
cord-011917-6u0t4hy8	138	4	focused	focus	VBN
cord-011917-6u0t4hy8	138	5	on	on	IN
cord-011917-6u0t4hy8	138	6	how	how	WRB
cord-011917-6u0t4hy8	138	7	pre	pre	JJ
cord-011917-6u0t4hy8	138	8	-	-	JJ
cord-011917-6u0t4hy8	138	9	immunity	immunity	JJ
cord-011917-6u0t4hy8	138	10	effects	effect	NNS
cord-011917-6u0t4hy8	138	11	vaccination	vaccination	NN
cord-011917-6u0t4hy8	138	12	responses	response	NNS
cord-011917-6u0t4hy8	138	13	and	and	CC
cord-011917-6u0t4hy8	138	14	general	general	JJ
cord-011917-6u0t4hy8	138	15	vaccine	vaccine	NN
cord-011917-6u0t4hy8	138	16	efficacies	efficacy	NNS
cord-011917-6u0t4hy8	138	17	to	to	IN
cord-011917-6u0t4hy8	138	18	any	any	DT
cord-011917-6u0t4hy8	138	19	virus	virus	NN
cord-011917-6u0t4hy8	138	20	,	,	,
cord-011917-6u0t4hy8	138	21	not	not	RB
cord-011917-6u0t4hy8	138	22	just	just	RB
cord-011917-6u0t4hy8	138	23	in	in	IN
cord-011917-6u0t4hy8	138	24	terms	term	NNS
cord-011917-6u0t4hy8	138	25	of	of	IN
cord-011917-6u0t4hy8	138	26	the	the	DT
cord-011917-6u0t4hy8	138	27	pandemic	pandemic	NN
cord-011917-6u0t4hy8	138	28	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	138	29	)	)	-RRB-
cord-011917-6u0t4hy8	139	1	(	(	-LRB-
cord-011917-6u0t4hy8	139	2	Tables	Tables	NNP
cord-011917-6u0t4hy8	139	3	S2	S2	NNP
cord-011917-6u0t4hy8	139	4	and	and	CC
cord-011917-6u0t4hy8	139	5	S3	S3	NNP
cord-011917-6u0t4hy8	139	6	)	)	-RRB-
cord-011917-6u0t4hy8	139	7	.	.	.
cord-011917-6u0t4hy8	140	1	Furthermore	furthermore	RB
cord-011917-6u0t4hy8	140	2	,	,	,
cord-011917-6u0t4hy8	140	3	the	the	DT
cord-011917-6u0t4hy8	140	4	pre	pre	JJ
cord-011917-6u0t4hy8	140	5	-	-	JJ
cord-011917-6u0t4hy8	140	6	immune	immune	JJ
cord-011917-6u0t4hy8	140	7	model	model	NN
cord-011917-6u0t4hy8	140	8	is	be	VBZ
cord-011917-6u0t4hy8	140	9	now	now	RB
cord-011917-6u0t4hy8	140	10	being	be	VBG
cord-011917-6u0t4hy8	140	11	used	use	VBN
cord-011917-6u0t4hy8	140	12	,	,	,
cord-011917-6u0t4hy8	140	13	in	in	IN
cord-011917-6u0t4hy8	140	14	replacement	replacement	NN
cord-011917-6u0t4hy8	140	15	of	of	IN
cord-011917-6u0t4hy8	140	16	a	a	DT
cord-011917-6u0t4hy8	140	17	naïve	naïve	JJ
cord-011917-6u0t4hy8	140	18	model	model	NN
cord-011917-6u0t4hy8	140	19	,	,	,
cord-011917-6u0t4hy8	140	20	to	to	TO
cord-011917-6u0t4hy8	140	21	test	test	VB
cord-011917-6u0t4hy8	140	22	novel	novel	JJ
cord-011917-6u0t4hy8	140	23	vaccine	vaccine	NN
cord-011917-6u0t4hy8	140	24	candidates	candidate	NNS
cord-011917-6u0t4hy8	140	25	and	and	CC
cord-011917-6u0t4hy8	140	26	methods	method	NNS
cord-011917-6u0t4hy8	140	27	currently	currently	RB
cord-011917-6u0t4hy8	140	28	in	in	IN
cord-011917-6u0t4hy8	140	29	research	research	NN
cord-011917-6u0t4hy8	140	30	and	and	CC
cord-011917-6u0t4hy8	140	31	development	development	NN
cord-011917-6u0t4hy8	140	32	[	[	-LRB-
cord-011917-6u0t4hy8	140	33	37	37	CD
cord-011917-6u0t4hy8	140	34	]	]	-RRB-
cord-011917-6u0t4hy8	140	35	.	.	.
cord-011917-6u0t4hy8	141	1	Sequential	sequential	JJ
cord-011917-6u0t4hy8	141	2	infections	infection	NNS
cord-011917-6u0t4hy8	141	3	of	of	IN
cord-011917-6u0t4hy8	141	4	antigenically	antigenically	RB
cord-011917-6u0t4hy8	141	5	distinct	distinct	JJ
cord-011917-6u0t4hy8	141	6	viruses	virus	NNS
cord-011917-6u0t4hy8	141	7	lead	lead	VBP
cord-011917-6u0t4hy8	141	8	to	to	IN
cord-011917-6u0t4hy8	141	9	a	a	DT
cord-011917-6u0t4hy8	141	10	broader	broad	JJR
cord-011917-6u0t4hy8	141	11	antibody	antibody	NN
cord-011917-6u0t4hy8	141	12	response	response	NN
cord-011917-6u0t4hy8	141	13	than	than	IN
cord-011917-6u0t4hy8	141	14	that	that	DT
cord-011917-6u0t4hy8	141	15	of	of	IN
cord-011917-6u0t4hy8	141	16	just	just	RB
cord-011917-6u0t4hy8	141	17	one	one	CD
cord-011917-6u0t4hy8	141	18	strain	strain	NN
cord-011917-6u0t4hy8	141	19	[	[	-LRB-
cord-011917-6u0t4hy8	141	20	59	59	CD
cord-011917-6u0t4hy8	141	21	,	,	,
cord-011917-6u0t4hy8	141	22	78	78	CD
cord-011917-6u0t4hy8	141	23	]	]	-RRB-
cord-011917-6u0t4hy8	141	24	.	.	.
cord-011917-6u0t4hy8	142	1	This	this	DT
cord-011917-6u0t4hy8	142	2	illustrated	illustrate	VBD
cord-011917-6u0t4hy8	142	3	the	the	DT
cord-011917-6u0t4hy8	142	4	importance	importance	NN
cord-011917-6u0t4hy8	142	5	of	of	IN
cord-011917-6u0t4hy8	142	6	using	use	VBG
cord-011917-6u0t4hy8	142	7	a	a	DT
cord-011917-6u0t4hy8	142	8	pre	pre	JJ
cord-011917-6u0t4hy8	142	9	-	-	JJ
cord-011917-6u0t4hy8	142	10	immune	immune	JJ
cord-011917-6u0t4hy8	142	11	model	model	NN
cord-011917-6u0t4hy8	142	12	for	for	IN
cord-011917-6u0t4hy8	142	13	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	142	14	characterization	characterization	NN
cord-011917-6u0t4hy8	142	15	and	and	CC
cord-011917-6u0t4hy8	142	16	vaccine	vaccine	NN
cord-011917-6u0t4hy8	142	17	testing	testing	NN
cord-011917-6u0t4hy8	142	18	.	.	.
cord-011917-6u0t4hy8	143	1	In	in	IN
cord-011917-6u0t4hy8	143	2	fact	fact	NN
cord-011917-6u0t4hy8	143	3	,	,	,
cord-011917-6u0t4hy8	143	4	when	when	WRB
cord-011917-6u0t4hy8	143	5	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	143	6	)	)	-RRB-
cord-011917-6u0t4hy8	143	7	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	143	8	maps	map	NNS
cord-011917-6u0t4hy8	143	9	were	be	VBD
cord-011917-6u0t4hy8	143	10	produced	produce	VBN
cord-011917-6u0t4hy8	143	11	using	use	VBG
cord-011917-6u0t4hy8	143	12	sera	sera	NNP
cord-011917-6u0t4hy8	143	13	from	from	IN
cord-011917-6u0t4hy8	143	14	naïve	naïve	JJ
cord-011917-6u0t4hy8	143	15	or	or	CC
cord-011917-6u0t4hy8	143	16	pre	pre	JJ
cord-011917-6u0t4hy8	143	17	-	-	JJ
cord-011917-6u0t4hy8	143	18	immune	immune	JJ
cord-011917-6u0t4hy8	143	19	ferrets	ferret	NNS
cord-011917-6u0t4hy8	143	20	the	the	DT
cord-011917-6u0t4hy8	143	21	maps	map	NNS
cord-011917-6u0t4hy8	143	22	poorly	poorly	RB
cord-011917-6u0t4hy8	143	23	correlated	correlate	VBN
cord-011917-6u0t4hy8	143	24	;	;	:
cord-011917-6u0t4hy8	143	25	the	the	DT
cord-011917-6u0t4hy8	143	26	classification	classification	NN
cord-011917-6u0t4hy8	143	27	of	of	IN
cord-011917-6u0t4hy8	143	28	whether	whether	IN
cord-011917-6u0t4hy8	143	29	two	two	CD
cord-011917-6u0t4hy8	143	30	viruses	virus	NNS
cord-011917-6u0t4hy8	143	31	were	be	VBD
cord-011917-6u0t4hy8	143	32	antigenically	antigenically	RB
cord-011917-6u0t4hy8	143	33	distinct	distinct	JJ
cord-011917-6u0t4hy8	143	34	or	or	CC
cord-011917-6u0t4hy8	143	35	similar	similar	JJ
cord-011917-6u0t4hy8	143	36	varied	varied	JJ
cord-011917-6u0t4hy8	143	37	with	with	IN
cord-011917-6u0t4hy8	143	38	the	the	DT
cord-011917-6u0t4hy8	143	39	model	model	NN
cord-011917-6u0t4hy8	143	40	(	(	-LRB-
cord-011917-6u0t4hy8	143	41	naïve	naïve	JJ
cord-011917-6u0t4hy8	143	42	or	or	CC
cord-011917-6u0t4hy8	143	43	pre	pre	JJ
cord-011917-6u0t4hy8	143	44	-	-	JJ
cord-011917-6u0t4hy8	143	45	immune	immune	JJ
cord-011917-6u0t4hy8	143	46	)	)	-RRB-
cord-011917-6u0t4hy8	143	47	[	[	-LRB-
cord-011917-6u0t4hy8	143	48	79	79	CD
cord-011917-6u0t4hy8	143	49	]	]	-RRB-
cord-011917-6u0t4hy8	143	50	.	.	.
cord-011917-6u0t4hy8	144	1	The	the	DT
cord-011917-6u0t4hy8	144	2	broader	broad	JJR
cord-011917-6u0t4hy8	144	3	antibody	antibody	NN
cord-011917-6u0t4hy8	144	4	response	response	NN
cord-011917-6u0t4hy8	144	5	characterized	characterize	VBN
cord-011917-6u0t4hy8	144	6	with	with	IN
cord-011917-6u0t4hy8	144	7	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	144	8	)	)	-RRB-
cord-011917-6u0t4hy8	144	9	or	or	CC
cord-011917-6u0t4hy8	144	10	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	144	11	)	)	-RRB-
cord-011917-6u0t4hy8	145	1	sequential	sequential	JJ
cord-011917-6u0t4hy8	145	2	infections	infection	NNS
cord-011917-6u0t4hy8	145	3	was	be	VBD
cord-011917-6u0t4hy8	145	4	extremely	extremely	RB
cord-011917-6u0t4hy8	145	5	informative	informative	JJ
cord-011917-6u0t4hy8	145	6	at	at	IN
cord-011917-6u0t4hy8	145	7	the	the	DT
cord-011917-6u0t4hy8	145	8	hetero	hetero	JJ
cord-011917-6u0t4hy8	145	9	-	-	HYPH
cord-011917-6u0t4hy8	145	10	subtype	subtype	NN
cord-011917-6u0t4hy8	145	11	level	level	NN
cord-011917-6u0t4hy8	145	12	[	[	-LRB-
cord-011917-6u0t4hy8	145	13	78	78	CD
cord-011917-6u0t4hy8	145	14	]	]	-RRB-
cord-011917-6u0t4hy8	145	15	.	.	.
cord-011917-6u0t4hy8	146	1	However	however	RB
cord-011917-6u0t4hy8	146	2	,	,	,
cord-011917-6u0t4hy8	146	3	the	the	DT
cord-011917-6u0t4hy8	146	4	impacts	impact	NNS
cord-011917-6u0t4hy8	146	5	of	of	IN
cord-011917-6u0t4hy8	146	6	other	other	JJ
cord-011917-6u0t4hy8	146	7	subtypes	subtype	NNS
cord-011917-6u0t4hy8	146	8	,	,	,
cord-011917-6u0t4hy8	146	9	such	such	JJ
cord-011917-6u0t4hy8	146	10	as	as	IN
cord-011917-6u0t4hy8	146	11	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	146	12	)	)	-RRB-
cord-011917-6u0t4hy8	146	13	and	and	CC
cord-011917-6u0t4hy8	146	14	A(H7N9	A(H7N9	NNP
cord-011917-6u0t4hy8	146	15	)	)	-RRB-
cord-011917-6u0t4hy8	146	16	were	be	VBD
cord-011917-6u0t4hy8	146	17	not	not	RB
cord-011917-6u0t4hy8	146	18	investigated	investigate	VBN
cord-011917-6u0t4hy8	146	19	,	,	,
cord-011917-6u0t4hy8	146	20	and	and	CC
cord-011917-6u0t4hy8	146	21	neither	neither	DT
cord-011917-6u0t4hy8	146	22	were	be	VBD
cord-011917-6u0t4hy8	146	23	the	the	DT
cord-011917-6u0t4hy8	146	24	nuances	nuance	NNS
cord-011917-6u0t4hy8	146	25	of	of	IN
cord-011917-6u0t4hy8	146	26	how	how	WRB
cord-011917-6u0t4hy8	146	27	protective	protective	JJ
cord-011917-6u0t4hy8	146	28	different	different	JJ
cord-011917-6u0t4hy8	146	29	antigenically	antigenically	NN
cord-011917-6u0t4hy8	146	30	drifted	drift	VBD
cord-011917-6u0t4hy8	146	31	strains	strain	NNS
cord-011917-6u0t4hy8	146	32	within	within	IN
cord-011917-6u0t4hy8	146	33	a	a	DT
cord-011917-6u0t4hy8	146	34	subtype	subtype	NN
cord-011917-6u0t4hy8	146	35	investigated	investigate	VBN
cord-011917-6u0t4hy8	146	36	.	.	.
cord-011917-6u0t4hy8	147	1	The	the	DT
cord-011917-6u0t4hy8	147	2	antibody	antibody	NN
cord-011917-6u0t4hy8	147	3	profiles	profile	NNS
cord-011917-6u0t4hy8	147	4	of	of	IN
cord-011917-6u0t4hy8	147	5	sequentially	sequentially	RB
cord-011917-6u0t4hy8	147	6	infected	infect	VBN
cord-011917-6u0t4hy8	147	7	ferrets	ferret	NNS
cord-011917-6u0t4hy8	147	8	with	with	IN
cord-011917-6u0t4hy8	147	9	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	147	10	)	)	-RRB-
cord-011917-6u0t4hy8	148	1	viruses	virus	NNS
cord-011917-6u0t4hy8	148	2	revealed	reveal	VBD
cord-011917-6u0t4hy8	148	3	that	that	IN
cord-011917-6u0t4hy8	148	4	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	148	5	)	)	-RRB-
cord-011917-6u0t4hy8	148	6	pre	pre	JJ
cord-011917-6u0t4hy8	148	7	-	-	NN
cord-011917-6u0t4hy8	148	8	immunity	immunity	NN
cord-011917-6u0t4hy8	148	9	affected	affect	VBD
cord-011917-6u0t4hy8	148	10	both	both	CC
cord-011917-6u0t4hy8	148	11	the	the	DT
cord-011917-6u0t4hy8	148	12	quantity	quantity	NN
cord-011917-6u0t4hy8	148	13	and	and	CC
cord-011917-6u0t4hy8	148	14	quality	quality	NN
cord-011917-6u0t4hy8	148	15	of	of	IN
cord-011917-6u0t4hy8	148	16	antibodies	antibody	NNS
cord-011917-6u0t4hy8	148	17	elicited	elicit	VBD
cord-011917-6u0t4hy8	148	18	[	[	-LRB-
cord-011917-6u0t4hy8	148	19	79	79	CD
cord-011917-6u0t4hy8	148	20	]	]	-RRB-
cord-011917-6u0t4hy8	148	21	.	.	.
cord-011917-6u0t4hy8	149	1	With	with	IN
cord-011917-6u0t4hy8	149	2	high	high	JJ
cord-011917-6u0t4hy8	149	3	HAI	HAI	NNP
cord-011917-6u0t4hy8	149	4	titers	titer	NNS
cord-011917-6u0t4hy8	149	5	against	against	IN
cord-011917-6u0t4hy8	149	6	the	the	DT
cord-011917-6u0t4hy8	149	7	imprinting	imprinting	NN
cord-011917-6u0t4hy8	149	8	virus	virus	NN
cord-011917-6u0t4hy8	149	9	,	,	,
cord-011917-6u0t4hy8	149	10	lower	low	JJR
cord-011917-6u0t4hy8	149	11	titers	titer	NNS
cord-011917-6u0t4hy8	149	12	were	be	VBD
cord-011917-6u0t4hy8	149	13	observed	observe	VBN
cord-011917-6u0t4hy8	149	14	toward	toward	IN
cord-011917-6u0t4hy8	149	15	the	the	DT
cord-011917-6u0t4hy8	149	16	most	most	RBS
cord-011917-6u0t4hy8	149	17	recent	recent	JJ
cord-011917-6u0t4hy8	149	18	isolate	isolate	NN
cord-011917-6u0t4hy8	149	19	,	,	,
cord-011917-6u0t4hy8	149	20	A(H3N2)/Hong	A(H3N2)/Hong	NNP
cord-011917-6u0t4hy8	149	21	Kong/4801/2014	Kong/4801/2014	NNS
cord-011917-6u0t4hy8	149	22	.	.	.
cord-011917-6u0t4hy8	150	1	After	after	IN
cord-011917-6u0t4hy8	150	2	repeated	repeat	VBN
cord-011917-6u0t4hy8	150	3	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	150	4	)	)	-RRB-
cord-011917-6u0t4hy8	150	5	infections	infection	NNS
cord-011917-6u0t4hy8	150	6	,	,	,
cord-011917-6u0t4hy8	150	7	the	the	DT
cord-011917-6u0t4hy8	150	8	antibody	antibody	NN
cord-011917-6u0t4hy8	150	9	avidities	avidities	NNP
cord-011917-6u0t4hy8	150	10	gradually	gradually	RB
cord-011917-6u0t4hy8	150	11	increased	increase	VBD
cord-011917-6u0t4hy8	150	12	for	for	IN
cord-011917-6u0t4hy8	150	13	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	150	14	)	)	-RRB-
cord-011917-6u0t4hy8	150	15	compared	compare	VBD
cord-011917-6u0t4hy8	150	16	to	to	IN
cord-011917-6u0t4hy8	150	17	those	those	DT
cord-011917-6u0t4hy8	150	18	from	from	IN
cord-011917-6u0t4hy8	150	19	a	a	DT
cord-011917-6u0t4hy8	150	20	single	single	JJ
cord-011917-6u0t4hy8	150	21	homologous	homologous	JJ
cord-011917-6u0t4hy8	150	22	infection	infection	NN
cord-011917-6u0t4hy8	150	23	.	.	.
cord-011917-6u0t4hy8	151	1	This	this	DT
cord-011917-6u0t4hy8	151	2	repeated	repeat	VBN
cord-011917-6u0t4hy8	151	3	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	151	4	)	)	-RRB-
cord-011917-6u0t4hy8	152	1	exposure	exposure	NN
cord-011917-6u0t4hy8	152	2	expanded	expand	VBD
cord-011917-6u0t4hy8	152	3	the	the	DT
cord-011917-6u0t4hy8	152	4	cross	cross	NN
cord-011917-6u0t4hy8	152	5	-	-	JJ
cord-011917-6u0t4hy8	152	6	reactivity	reactivity	JJ
cord-011917-6u0t4hy8	152	7	breadth	breadth	NN
cord-011917-6u0t4hy8	152	8	against	against	IN
cord-011917-6u0t4hy8	152	9	the	the	DT
cord-011917-6u0t4hy8	152	10	same	same	JJ
cord-011917-6u0t4hy8	152	11	HAI	HAI	NNP
cord-011917-6u0t4hy8	152	12	panel	panel	NN
cord-011917-6u0t4hy8	152	13	.	.	.
cord-011917-6u0t4hy8	153	1	With	with	IN
cord-011917-6u0t4hy8	153	2	computationally	computationally	RB
cord-011917-6u0t4hy8	153	3	optimized	optimize	VBN
cord-011917-6u0t4hy8	153	4	HA	HA	NNP
cord-011917-6u0t4hy8	153	5	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	153	6	,	,	,
cord-011917-6u0t4hy8	153	7	the	the	DT
cord-011917-6u0t4hy8	153	8	same	same	JJ
cord-011917-6u0t4hy8	153	9	increased	increase	VBN
cord-011917-6u0t4hy8	153	10	breadth	breadth	NN
cord-011917-6u0t4hy8	153	11	phenomenon	phenomenon	NN
cord-011917-6u0t4hy8	153	12	,	,	,
cord-011917-6u0t4hy8	153	13	back	back	NN
cord-011917-6u0t4hy8	153	14	-	-	HYPH
cord-011917-6u0t4hy8	153	15	boosting	boosting	NN
cord-011917-6u0t4hy8	153	16	,	,	,
cord-011917-6u0t4hy8	153	17	occurred	occur	VBD
cord-011917-6u0t4hy8	153	18	.	.	.
cord-011917-6u0t4hy8	154	1	Pre	pre	JJ
cord-011917-6u0t4hy8	154	2	-	-	NN
cord-011917-6u0t4hy8	154	3	immunity	immunity	NN
cord-011917-6u0t4hy8	155	1	to	to	IN
cord-011917-6u0t4hy8	155	2	a	a	DT
cord-011917-6u0t4hy8	155	3	historical	historical	JJ
cord-011917-6u0t4hy8	155	4	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	155	5	)	)	-RRB-
cord-011917-6u0t4hy8	155	6	virus	virus	NN
cord-011917-6u0t4hy8	155	7	helped	help	VBD
cord-011917-6u0t4hy8	155	8	boost	boost	VB
cord-011917-6u0t4hy8	155	9	the	the	DT
cord-011917-6u0t4hy8	155	10	magnitude	magnitude	NN
cord-011917-6u0t4hy8	155	11	and	and	CC
cord-011917-6u0t4hy8	155	12	breadth	breadth	NN
cord-011917-6u0t4hy8	155	13	of	of	IN
cord-011917-6u0t4hy8	155	14	the	the	DT
cord-011917-6u0t4hy8	155	15	broadly	broadly	RB
cord-011917-6u0t4hy8	155	16	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	155	17	antibodies	antibody	NNS
cord-011917-6u0t4hy8	155	18	elicited	elicit	VBN
cord-011917-6u0t4hy8	155	19	by	by	IN
cord-011917-6u0t4hy8	155	20	computationally	computationally	RB
cord-011917-6u0t4hy8	155	21	optimized	optimize	VBN
cord-011917-6u0t4hy8	155	22	broadly	broadly	RB
cord-011917-6u0t4hy8	155	23	reactive	reactive	JJ
cord-011917-6u0t4hy8	155	24	antigen	antigen	NN
cord-011917-6u0t4hy8	155	25	(	(	-LRB-
cord-011917-6u0t4hy8	155	26	COBRA	COBRA	NNP
cord-011917-6u0t4hy8	155	27	)	)	-RRB-
cord-011917-6u0t4hy8	155	28	immunogens	immunogen	NNS
cord-011917-6u0t4hy8	155	29	compared	compare	VBN
cord-011917-6u0t4hy8	155	30	to	to	IN
cord-011917-6u0t4hy8	155	31	a	a	DT
cord-011917-6u0t4hy8	155	32	naïve	naïve	JJ
cord-011917-6u0t4hy8	155	33	ferret	ferret	NN
cord-011917-6u0t4hy8	155	34	group	group	NN
cord-011917-6u0t4hy8	155	35	[	[	-LRB-
cord-011917-6u0t4hy8	155	36	37	37	CD
cord-011917-6u0t4hy8	155	37	]	]	-RRB-
cord-011917-6u0t4hy8	155	38	.	.	.
cord-011917-6u0t4hy8	156	1	Emphasis	emphasis	NN
cord-011917-6u0t4hy8	156	2	was	be	VBD
cord-011917-6u0t4hy8	156	3	placed	place	VBN
cord-011917-6u0t4hy8	156	4	on	on	IN
cord-011917-6u0t4hy8	156	5	the	the	DT
cord-011917-6u0t4hy8	156	6	concept	concept	NN
cord-011917-6u0t4hy8	156	7	that	that	WDT
cord-011917-6u0t4hy8	156	8	testing	test	VBG
cord-011917-6u0t4hy8	156	9	vaccine	vaccine	NN
cord-011917-6u0t4hy8	156	10	candidates	candidate	NNS
cord-011917-6u0t4hy8	156	11	in	in	IN
cord-011917-6u0t4hy8	156	12	naïve	naïve	JJ
cord-011917-6u0t4hy8	156	13	ferrets	ferret	NNS
cord-011917-6u0t4hy8	156	14	do	do	VBP
cord-011917-6u0t4hy8	156	15	not	not	RB
cord-011917-6u0t4hy8	156	16	reflect	reflect	VB
cord-011917-6u0t4hy8	156	17	the	the	DT
cord-011917-6u0t4hy8	156	18	performance	performance	NN
cord-011917-6u0t4hy8	156	19	of	of	IN
cord-011917-6u0t4hy8	156	20	the	the	DT
cord-011917-6u0t4hy8	156	21	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	156	22	in	in	IN
cord-011917-6u0t4hy8	156	23	the	the	DT
cord-011917-6u0t4hy8	156	24	human	human	JJ
cord-011917-6u0t4hy8	156	25	population	population	NN
cord-011917-6u0t4hy8	156	26	.	.	.
cord-011917-6u0t4hy8	157	1	In	in	IN
cord-011917-6u0t4hy8	157	2	an	an	DT
cord-011917-6u0t4hy8	157	3	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	157	4	)	)	-RRB-
cord-011917-6u0t4hy8	157	5	primed	prime	VBN
cord-011917-6u0t4hy8	157	6	model	model	NN
cord-011917-6u0t4hy8	157	7	,	,	,
cord-011917-6u0t4hy8	157	8	greater	great	JJR
cord-011917-6u0t4hy8	157	9	protection	protection	NN
cord-011917-6u0t4hy8	157	10	after	after	IN
cord-011917-6u0t4hy8	157	11	vaccination	vaccination	NN
cord-011917-6u0t4hy8	157	12	was	be	VBD
cord-011917-6u0t4hy8	157	13	observed	observe	VBN
cord-011917-6u0t4hy8	157	14	[	[	-LRB-
cord-011917-6u0t4hy8	157	15	18	18	CD
cord-011917-6u0t4hy8	157	16	]	]	-RRB-
cord-011917-6u0t4hy8	157	17	.	.	.
cord-011917-6u0t4hy8	158	1	Vaccine	vaccine	NN
cord-011917-6u0t4hy8	158	2	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	158	3	varies	vary	VBZ
cord-011917-6u0t4hy8	158	4	in	in	IN
cord-011917-6u0t4hy8	158	5	the	the	DT
cord-011917-6u0t4hy8	158	6	human	human	JJ
cord-011917-6u0t4hy8	158	7	population	population	NN
cord-011917-6u0t4hy8	158	8	from	from	IN
cord-011917-6u0t4hy8	158	9	season	season	NN
cord-011917-6u0t4hy8	158	10	to	to	IN
cord-011917-6u0t4hy8	158	11	season	season	NN
cord-011917-6u0t4hy8	158	12	.	.	.
cord-011917-6u0t4hy8	159	1	Epidemiological	epidemiological	JJ
cord-011917-6u0t4hy8	159	2	data	datum	NNS
cord-011917-6u0t4hy8	159	3	from	from	IN
cord-011917-6u0t4hy8	159	4	people	people	NNS
cord-011917-6u0t4hy8	159	5	suggests	suggest	VBZ
cord-011917-6u0t4hy8	159	6	that	that	IN
cord-011917-6u0t4hy8	159	7	pre	pre	JJ
cord-011917-6u0t4hy8	159	8	-	-	JJ
cord-011917-6u0t4hy8	159	9	existing	existing	JJ
cord-011917-6u0t4hy8	159	10	immunity	immunity	NN
cord-011917-6u0t4hy8	159	11	can	can	MD
cord-011917-6u0t4hy8	159	12	result	result	VB
cord-011917-6u0t4hy8	159	13	in	in	IN
cord-011917-6u0t4hy8	159	14	decreased	decreased	JJ
cord-011917-6u0t4hy8	159	15	vaccine	vaccine	NN
cord-011917-6u0t4hy8	159	16	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	159	17	[	[	-LRB-
cord-011917-6u0t4hy8	159	18	80	80	CD
cord-011917-6u0t4hy8	159	19	]	]	-RRB-
cord-011917-6u0t4hy8	159	20	[	[	-LRB-
cord-011917-6u0t4hy8	159	21	81	81	CD
cord-011917-6u0t4hy8	159	22	]	]	-RRB-
cord-011917-6u0t4hy8	159	23	[	[	-LRB-
cord-011917-6u0t4hy8	159	24	82	82	CD
cord-011917-6u0t4hy8	159	25	]	]	-RRB-
cord-011917-6u0t4hy8	159	26	.	.	.
cord-011917-6u0t4hy8	160	1	The	the	DT
cord-011917-6u0t4hy8	160	2	pre	pre	JJ
cord-011917-6u0t4hy8	160	3	-	-	JJ
cord-011917-6u0t4hy8	160	4	immune	immune	JJ
cord-011917-6u0t4hy8	160	5	model	model	NN
cord-011917-6u0t4hy8	160	6	has	have	VBZ
cord-011917-6u0t4hy8	160	7	been	be	VBN
cord-011917-6u0t4hy8	160	8	used	use	VBN
cord-011917-6u0t4hy8	160	9	to	to	TO
cord-011917-6u0t4hy8	160	10	study	study	VB
cord-011917-6u0t4hy8	160	11	how	how	WRB
cord-011917-6u0t4hy8	160	12	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	160	13	can	can	MD
cord-011917-6u0t4hy8	160	14	overcome	overcome	VB
cord-011917-6u0t4hy8	160	15	pre	pre	VB
cord-011917-6u0t4hy8	160	16	-	-	JJ
cord-011917-6u0t4hy8	160	17	existing	existing	JJ
cord-011917-6u0t4hy8	160	18	immunity	immunity	NN
cord-011917-6u0t4hy8	160	19	to	to	TO
cord-011917-6u0t4hy8	160	20	mount	mount	VB
cord-011917-6u0t4hy8	160	21	a	a	DT
cord-011917-6u0t4hy8	160	22	new	new	JJ
cord-011917-6u0t4hy8	160	23	response	response	NN
cord-011917-6u0t4hy8	160	24	with	with	IN
cord-011917-6u0t4hy8	160	25	M2-deficient	M2-deficient	NNP
cord-011917-6u0t4hy8	161	1	single	single	JJ
cord-011917-6u0t4hy8	161	2	replicon	replicon	NN
cord-011917-6u0t4hy8	161	3	vaccine	vaccine	NN
cord-011917-6u0t4hy8	161	4	candidates	candidate	NNS
cord-011917-6u0t4hy8	161	5	for	for	IN
cord-011917-6u0t4hy8	161	6	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	161	7	)	)	-RRB-
cord-011917-6u0t4hy8	161	8	and	and	CC
cord-011917-6u0t4hy8	161	9	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	161	10	)	)	-RRB-
cord-011917-6u0t4hy8	161	11	subtypes	subtype	NNS
cord-011917-6u0t4hy8	161	12	[	[	-LRB-
cord-011917-6u0t4hy8	161	13	83	83	CD
cord-011917-6u0t4hy8	161	14	]	]	-RRB-
cord-011917-6u0t4hy8	161	15	.	.	.
cord-011917-6u0t4hy8	162	1	Type	type	NN
cord-011917-6u0t4hy8	162	2	B	b	NN
cord-011917-6u0t4hy8	162	3	and	and	CC
cord-011917-6u0t4hy8	162	4	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	162	5	)	)	-RRB-
cord-011917-6u0t4hy8	163	1	heterosubtypic	heterosubtypic	NNP
cord-011917-6u0t4hy8	163	2	pre	pre	JJ
cord-011917-6u0t4hy8	163	3	-	-	NN
cord-011917-6u0t4hy8	163	4	immunity	immunity	NN
cord-011917-6u0t4hy8	163	5	followed	follow	VBN
cord-011917-6u0t4hy8	163	6	by	by	IN
cord-011917-6u0t4hy8	163	7	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	163	8	)	)	-RRB-
cord-011917-6u0t4hy8	163	9	vaccination	vaccination	NN
cord-011917-6u0t4hy8	163	10	provided	provide	VBD
cord-011917-6u0t4hy8	163	11	protection	protection	NN
cord-011917-6u0t4hy8	163	12	against	against	IN
cord-011917-6u0t4hy8	163	13	an	an	DT
cord-011917-6u0t4hy8	163	14	antigenically	antigenically	RB
cord-011917-6u0t4hy8	163	15	distinct	distinct	JJ
cord-011917-6u0t4hy8	163	16	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	163	17	)	)	-RRB-
cord-011917-6u0t4hy8	163	18	challenge	challenge	NN
cord-011917-6u0t4hy8	163	19	.	.	.
cord-011917-6u0t4hy8	164	1	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	164	2	)	)	-RRB-
cord-011917-6u0t4hy8	165	1	pandemic	pandemic	NNP
cord-011917-6u0t4hy8	165	2	homosubtypic	homosubtypic	NNP
cord-011917-6u0t4hy8	165	3	imprinting	imprint	VBG
cord-011917-6u0t4hy8	165	4	negatively	negatively	RB
cord-011917-6u0t4hy8	165	5	affected	affect	VBD
cord-011917-6u0t4hy8	165	6	the	the	DT
cord-011917-6u0t4hy8	165	7	ability	ability	NN
cord-011917-6u0t4hy8	165	8	of	of	IN
cord-011917-6u0t4hy8	165	9	a	a	DT
cord-011917-6u0t4hy8	165	10	FluMist	FluMist	NNP
cord-011917-6u0t4hy8	165	11	-	-	HYPH
cord-011917-6u0t4hy8	165	12	like	like	JJ
cord-011917-6u0t4hy8	165	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	165	14	to	to	TO
cord-011917-6u0t4hy8	165	15	elicit	elicit	VB
cord-011917-6u0t4hy8	165	16	protection	protection	NN
cord-011917-6u0t4hy8	165	17	towards	towards	IN
cord-011917-6u0t4hy8	165	18	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	165	19	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	165	20	)	)	-RRB-
cord-011917-6u0t4hy8	166	1	[	[	-LRB-
cord-011917-6u0t4hy8	166	2	83	83	CD
cord-011917-6u0t4hy8	166	3	]	]	-RRB-
cord-011917-6u0t4hy8	166	4	.	.	.
cord-011917-6u0t4hy8	167	1	These	these	DT
cord-011917-6u0t4hy8	167	2	key	key	JJ
cord-011917-6u0t4hy8	167	3	findings	finding	NNS
cord-011917-6u0t4hy8	167	4	highlight	highlight	VBP
cord-011917-6u0t4hy8	167	5	the	the	DT
cord-011917-6u0t4hy8	167	6	difficulty	difficulty	NN
cord-011917-6u0t4hy8	167	7	with	with	IN
cord-011917-6u0t4hy8	167	8	inducing	induce	VBG
cord-011917-6u0t4hy8	167	9	immunity	immunity	NN
cord-011917-6u0t4hy8	167	10	to	to	IN
cord-011917-6u0t4hy8	167	11	a	a	DT
cord-011917-6u0t4hy8	167	12	novel	novel	NN
cord-011917-6u0t4hy8	167	13	HA	HA	NNP
cord-011917-6u0t4hy8	167	14	in	in	IN
cord-011917-6u0t4hy8	167	15	the	the	DT
cord-011917-6u0t4hy8	167	16	presence	presence	NN
cord-011917-6u0t4hy8	167	17	of	of	IN
cord-011917-6u0t4hy8	167	18	pre	pre	JJ
cord-011917-6u0t4hy8	167	19	-	-	JJ
cord-011917-6u0t4hy8	167	20	existing	existing	JJ
cord-011917-6u0t4hy8	167	21	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	167	22	,	,	,
cord-011917-6u0t4hy8	167	23	heterosubtypic	heterosubtypic	NNP
cord-011917-6u0t4hy8	167	24	,	,	,
cord-011917-6u0t4hy8	167	25	and	and	CC
cord-011917-6u0t4hy8	167	26	homosubtypic	homosubtypic	NNP
cord-011917-6u0t4hy8	167	27	immunity	immunity	NN
cord-011917-6u0t4hy8	167	28	.	.	.
cord-011917-6u0t4hy8	168	1	Although	although	IN
cord-011917-6u0t4hy8	168	2	the	the	DT
cord-011917-6u0t4hy8	168	3	questions	question	NNS
cord-011917-6u0t4hy8	168	4	surrounding	surround	VBG
cord-011917-6u0t4hy8	168	5	the	the	DT
cord-011917-6u0t4hy8	168	6	2009	2009	CD
cord-011917-6u0t4hy8	168	7	outbreak	outbreak	NN
cord-011917-6u0t4hy8	168	8	have	have	VBP
cord-011917-6u0t4hy8	168	9	been	be	VBN
cord-011917-6u0t4hy8	168	10	sufficiently	sufficiently	RB
cord-011917-6u0t4hy8	168	11	answered	answer	VBN
cord-011917-6u0t4hy8	168	12	,	,	,
cord-011917-6u0t4hy8	168	13	there	there	EX
cord-011917-6u0t4hy8	168	14	still	still	RB
cord-011917-6u0t4hy8	168	15	remains	remain	VBZ
cord-011917-6u0t4hy8	168	16	the	the	DT
cord-011917-6u0t4hy8	168	17	possibility	possibility	NN
cord-011917-6u0t4hy8	168	18	for	for	IN
cord-011917-6u0t4hy8	168	19	a	a	DT
cord-011917-6u0t4hy8	168	20	second	second	JJ
cord-011917-6u0t4hy8	168	21	swine	swine	NN
cord-011917-6u0t4hy8	168	22	-	-	HYPH
cord-011917-6u0t4hy8	168	23	origin	origin	NN
cord-011917-6u0t4hy8	168	24	pandemic	pandemic	NN
cord-011917-6u0t4hy8	168	25	.	.	.
cord-011917-6u0t4hy8	169	1	Even	even	RB
cord-011917-6u0t4hy8	169	2	of	of	IN
cord-011917-6u0t4hy8	169	3	the	the	DT
cord-011917-6u0t4hy8	169	4	same	same	JJ
cord-011917-6u0t4hy8	169	5	subtype	subtype	NN
cord-011917-6u0t4hy8	169	6	and	and	CC
cord-011917-6u0t4hy8	169	7	species	species	NN
cord-011917-6u0t4hy8	169	8	origin	origin	NN
cord-011917-6u0t4hy8	169	9	,	,	,
cord-011917-6u0t4hy8	169	10	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	169	11	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	169	12	)	)	-RRB-
cord-011917-6u0t4hy8	169	13	pre	pre	JJ
cord-011917-6u0t4hy8	169	14	-	-	JJ
cord-011917-6u0t4hy8	169	15	existing	existing	JJ
cord-011917-6u0t4hy8	169	16	immunity	immunity	NN
cord-011917-6u0t4hy8	169	17	was	be	VBD
cord-011917-6u0t4hy8	169	18	unable	unable	JJ
cord-011917-6u0t4hy8	169	19	to	to	TO
cord-011917-6u0t4hy8	169	20	induce	induce	VB
cord-011917-6u0t4hy8	169	21	sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	169	22	immunity	immunity	NN
cord-011917-6u0t4hy8	169	23	to	to	IN
cord-011917-6u0t4hy8	169	24	current	current	JJ
cord-011917-6u0t4hy8	169	25	circulating	circulate	VBG
cord-011917-6u0t4hy8	169	26	swine	swine	NN
cord-011917-6u0t4hy8	169	27	-	-	HYPH
cord-011917-6u0t4hy8	169	28	origin	origin	NN
cord-011917-6u0t4hy8	169	29	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	169	30	)	)	-RRB-
cord-011917-6u0t4hy8	169	31	viruses	virus	NNS
cord-011917-6u0t4hy8	169	32	[	[	-LRB-
cord-011917-6u0t4hy8	169	33	84	84	CD
cord-011917-6u0t4hy8	169	34	]	]	-RRB-
cord-011917-6u0t4hy8	169	35	.	.	.
cord-011917-6u0t4hy8	170	1	Furthermore	furthermore	RB
cord-011917-6u0t4hy8	170	2	,	,	,
cord-011917-6u0t4hy8	170	3	other	other	JJ
cord-011917-6u0t4hy8	170	4	subtypes	subtype	NNS
cord-011917-6u0t4hy8	170	5	-	-	:
cord-011917-6u0t4hy8	170	6	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	170	7	)	)	-RRB-
cord-011917-6u0t4hy8	170	8	and	and	CC
cord-011917-6u0t4hy8	170	9	A(H1N2)-circulate	A(H1N2)-circulate	NNP
cord-011917-6u0t4hy8	170	10	in	in	IN
cord-011917-6u0t4hy8	170	11	swine	swine	NN
cord-011917-6u0t4hy8	170	12	and	and	CC
cord-011917-6u0t4hy8	170	13	transmit	transmit	VB
cord-011917-6u0t4hy8	170	14	into	into	IN
cord-011917-6u0t4hy8	170	15	the	the	DT
cord-011917-6u0t4hy8	170	16	human	human	JJ
cord-011917-6u0t4hy8	170	17	population	population	NN
cord-011917-6u0t4hy8	170	18	[	[	-LRB-
cord-011917-6u0t4hy8	170	19	85	85	CD
cord-011917-6u0t4hy8	170	20	]	]	-RRB-
cord-011917-6u0t4hy8	170	21	.	.	.
cord-011917-6u0t4hy8	171	1	The	the	DT
cord-011917-6u0t4hy8	171	2	swine	swine	NN
cord-011917-6u0t4hy8	171	3	-	-	HYPH
cord-011917-6u0t4hy8	171	4	origin	origin	NN
cord-011917-6u0t4hy8	171	5	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	171	6	)	)	-RRB-
cord-011917-6u0t4hy8	171	7	subtype	subtype	NN
cord-011917-6u0t4hy8	171	8	raises	raise	VBZ
cord-011917-6u0t4hy8	171	9	concerns	concern	NNS
cord-011917-6u0t4hy8	171	10	due	due	IN
cord-011917-6u0t4hy8	171	11	to	to	IN
cord-011917-6u0t4hy8	171	12	human	human	NN
cord-011917-6u0t4hy8	171	13	's	's	POS
cord-011917-6u0t4hy8	171	14	documented	document	VBN
cord-011917-6u0t4hy8	171	15	susceptibility	susceptibility	NN
cord-011917-6u0t4hy8	171	16	to	to	IN
cord-011917-6u0t4hy8	171	17	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	171	18	)	)	-RRB-
cord-011917-6u0t4hy8	171	19	viruses	virus	NNS
cord-011917-6u0t4hy8	171	20	,	,	,
cord-011917-6u0t4hy8	171	21	and	and	CC
cord-011917-6u0t4hy8	171	22	transmission	transmission	NN
cord-011917-6u0t4hy8	171	23	in	in	IN
cord-011917-6u0t4hy8	171	24	ferrets	ferret	NNS
cord-011917-6u0t4hy8	171	25	being	be	VBG
cord-011917-6u0t4hy8	171	26	as	as	RB
cord-011917-6u0t4hy8	171	27	efficient	efficient	JJ
cord-011917-6u0t4hy8	171	28	as	as	IN
cord-011917-6u0t4hy8	171	29	human	human	JJ
cord-011917-6u0t4hy8	171	30	-	-	HYPH
cord-011917-6u0t4hy8	171	31	origin	origin	NN
cord-011917-6u0t4hy8	171	32	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	171	33	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	171	34	)	)	-RRB-
cord-011917-6u0t4hy8	171	35	viruses	virus	NNS
cord-011917-6u0t4hy8	171	36	[	[	-LRB-
cord-011917-6u0t4hy8	171	37	86	86	CD
cord-011917-6u0t4hy8	171	38	]	]	-RRB-
cord-011917-6u0t4hy8	171	39	.	.	.
cord-011917-6u0t4hy8	172	1	Differing	differ	VBG
cord-011917-6u0t4hy8	172	2	pre	pre	JJ
cord-011917-6u0t4hy8	172	3	-	-	NN
cord-011917-6u0t4hy8	172	4	immunity	immunity	NN
cord-011917-6u0t4hy8	172	5	may	may	MD
cord-011917-6u0t4hy8	172	6	be	be	VB
cord-011917-6u0t4hy8	172	7	protective	protective	JJ
cord-011917-6u0t4hy8	172	8	against	against	IN
cord-011917-6u0t4hy8	172	9	these	these	DT
cord-011917-6u0t4hy8	172	10	swine	swine	NN
cord-011917-6u0t4hy8	172	11	-	-	HYPH
cord-011917-6u0t4hy8	172	12	origin	origin	NN
cord-011917-6u0t4hy8	172	13	viruses	virus	NNS
cord-011917-6u0t4hy8	172	14	;	;	,
cord-011917-6u0t4hy8	172	15	pre	pre	JJ
cord-011917-6u0t4hy8	172	16	-	-	NN
cord-011917-6u0t4hy8	172	17	immunity	immunity	NN
cord-011917-6u0t4hy8	172	18	with	with	IN
cord-011917-6u0t4hy8	172	19	the	the	DT
cord-011917-6u0t4hy8	172	20	human	human	NN
cord-011917-6u0t4hy8	172	21	A(H3N2)/Perth/16/2009	a(h3n2)/perth/16/2009	CD
cord-011917-6u0t4hy8	173	1	cross	cross	JJ
cord-011917-6u0t4hy8	173	2	-	-	JJ
cord-011917-6u0t4hy8	173	3	protected	protect	VBN
cord-011917-6u0t4hy8	173	4	against	against	IN
cord-011917-6u0t4hy8	173	5	a	a	DT
cord-011917-6u0t4hy8	173	6	swine	swine	NN
cord-011917-6u0t4hy8	173	7	-	-	HYPH
cord-011917-6u0t4hy8	173	8	origin	origin	NN
cord-011917-6u0t4hy8	173	9	variant	variant	NN
cord-011917-6u0t4hy8	173	10	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	173	11	)	)	-RRB-
cord-011917-6u0t4hy8	173	12	,	,	,
cord-011917-6u0t4hy8	173	13	whereas	whereas	IN
cord-011917-6u0t4hy8	173	14	other	other	JJ
cord-011917-6u0t4hy8	173	15	human	human	JJ
cord-011917-6u0t4hy8	173	16	strains	strain	NNS
cord-011917-6u0t4hy8	173	17	did	do	VBD
cord-011917-6u0t4hy8	173	18	not	not	RB
cord-011917-6u0t4hy8	173	19	[	[	-LRB-
cord-011917-6u0t4hy8	173	20	26	26	CD
cord-011917-6u0t4hy8	173	21	]	]	-RRB-
cord-011917-6u0t4hy8	173	22	.	.	.
cord-011917-6u0t4hy8	174	1	Hence	hence	RB
cord-011917-6u0t4hy8	174	2	,	,	,
cord-011917-6u0t4hy8	174	3	prior	prior	JJ
cord-011917-6u0t4hy8	174	4	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	174	5	virus	virus	NN
cord-011917-6u0t4hy8	174	6	infections	infection	NNS
cord-011917-6u0t4hy8	174	7	may	may	MD
cord-011917-6u0t4hy8	174	8	be	be	VB
cord-011917-6u0t4hy8	174	9	protective	protective	JJ
cord-011917-6u0t4hy8	174	10	by	by	IN
cord-011917-6u0t4hy8	174	11	limiting	limit	VBG
cord-011917-6u0t4hy8	174	12	viral	viral	JJ
cord-011917-6u0t4hy8	174	13	replication	replication	NN
cord-011917-6u0t4hy8	174	14	and	and	CC
cord-011917-6u0t4hy8	174	15	reducing	reduce	VBG
cord-011917-6u0t4hy8	174	16	transmission	transmission	NN
cord-011917-6u0t4hy8	174	17	.	.	.
cord-011917-6u0t4hy8	175	1	This	this	DT
cord-011917-6u0t4hy8	175	2	may	may	MD
cord-011917-6u0t4hy8	175	3	suggest	suggest	VB
cord-011917-6u0t4hy8	175	4	that	that	IN
cord-011917-6u0t4hy8	175	5	within	within	IN
cord-011917-6u0t4hy8	175	6	the	the	DT
cord-011917-6u0t4hy8	175	7	human	human	JJ
cord-011917-6u0t4hy8	175	8	population	population	NN
cord-011917-6u0t4hy8	175	9	,	,	,
cord-011917-6u0t4hy8	175	10	different	different	JJ
cord-011917-6u0t4hy8	175	11	age	age	NN
cord-011917-6u0t4hy8	175	12	groups	group	NNS
cord-011917-6u0t4hy8	175	13	are	be	VBP
cord-011917-6u0t4hy8	175	14	more	more	RBR
cord-011917-6u0t4hy8	175	15	susceptible	susceptible	JJ
cord-011917-6u0t4hy8	175	16	to	to	IN
cord-011917-6u0t4hy8	175	17	certain	certain	JJ
cord-011917-6u0t4hy8	175	18	transmission	transmission	NN
cord-011917-6u0t4hy8	175	19	events	event	NNS
cord-011917-6u0t4hy8	175	20	depending	depend	VBG
cord-011917-6u0t4hy8	175	21	on	on	IN
cord-011917-6u0t4hy8	175	22	the	the	DT
cord-011917-6u0t4hy8	175	23	subtypes	subtype	NNS
cord-011917-6u0t4hy8	175	24	of	of	IN
cord-011917-6u0t4hy8	175	25	influenza	influenza	NN
cord-011917-6u0t4hy8	175	26	virus	virus	NN
cord-011917-6u0t4hy8	175	27	that	that	WDT
cord-011917-6u0t4hy8	175	28	they	-PRON-	PRP
cord-011917-6u0t4hy8	175	29	have	have	VBP
cord-011917-6u0t4hy8	175	30	previously	previously	RB
cord-011917-6u0t4hy8	175	31	been	be	VBN
cord-011917-6u0t4hy8	175	32	exposed	expose	VBN
cord-011917-6u0t4hy8	175	33	to	to	IN
cord-011917-6u0t4hy8	175	34	[	[	-LRB-
cord-011917-6u0t4hy8	175	35	4	4	CD
cord-011917-6u0t4hy8	175	36	]	]	-RRB-
cord-011917-6u0t4hy8	175	37	.	.	.
cord-011917-6u0t4hy8	176	1	The	the	DT
cord-011917-6u0t4hy8	176	2	ferret	ferret	JJ
cord-011917-6u0t4hy8	176	3	immune	immune	JJ
cord-011917-6u0t4hy8	176	4	response	response	NN
cord-011917-6u0t4hy8	176	5	to	to	IN
cord-011917-6u0t4hy8	176	6	reinfection	reinfection	NN
cord-011917-6u0t4hy8	176	7	is	be	VBZ
cord-011917-6u0t4hy8	176	8	strikingly	strikingly	RB
cord-011917-6u0t4hy8	176	9	different	different	JJ
cord-011917-6u0t4hy8	176	10	compared	compare	VBN
cord-011917-6u0t4hy8	176	11	to	to	IN
cord-011917-6u0t4hy8	176	12	the	the	DT
cord-011917-6u0t4hy8	176	13	response	response	NN
cord-011917-6u0t4hy8	176	14	after	after	IN
cord-011917-6u0t4hy8	176	15	a	a	DT
cord-011917-6u0t4hy8	176	16	primary	primary	JJ
cord-011917-6u0t4hy8	176	17	infection	infection	NN
cord-011917-6u0t4hy8	176	18	[	[	-LRB-
cord-011917-6u0t4hy8	176	19	87	87	CD
cord-011917-6u0t4hy8	176	20	]	]	-RRB-
cord-011917-6u0t4hy8	176	21	.	.	.
cord-011917-6u0t4hy8	177	1	When	when	WRB
cord-011917-6u0t4hy8	177	2	comparing	compare	VBG
cord-011917-6u0t4hy8	177	3	A(H1N1)/Mexico/4108/2009	A(H1N1)/Mexico/4108/2009	NNP
cord-011917-6u0t4hy8	177	4	challenge	challenge	NN
cord-011917-6u0t4hy8	177	5	in	in	IN
cord-011917-6u0t4hy8	177	6	naïve	naïve	JJ
cord-011917-6u0t4hy8	177	7	and	and	CC
cord-011917-6u0t4hy8	177	8	A(H1N1)/Mexico/4108/2009	A(H1N1)/Mexico/4108/2009	NNP
cord-011917-6u0t4hy8	177	9	pre	pre	JJ
cord-011917-6u0t4hy8	177	10	-	-	JJ
cord-011917-6u0t4hy8	177	11	immune	immune	JJ
cord-011917-6u0t4hy8	177	12	ferrets	ferret	NNS
cord-011917-6u0t4hy8	177	13	,	,	,
cord-011917-6u0t4hy8	177	14	the	the	DT
cord-011917-6u0t4hy8	177	15	pre	pre	JJ
cord-011917-6u0t4hy8	177	16	-	-	JJ
cord-011917-6u0t4hy8	177	17	immunity	immunity	JJ
cord-011917-6u0t4hy8	177	18	status	status	NN
cord-011917-6u0t4hy8	177	19	limited	limit	VBN
cord-011917-6u0t4hy8	177	20	viral	viral	JJ
cord-011917-6u0t4hy8	177	21	titers	titer	NNS
cord-011917-6u0t4hy8	177	22	.	.	.
cord-011917-6u0t4hy8	178	1	The	the	DT
cord-011917-6u0t4hy8	178	2	virus	virus	NN
cord-011917-6u0t4hy8	178	3	was	be	VBD
cord-011917-6u0t4hy8	178	4	still	still	RB
cord-011917-6u0t4hy8	178	5	detectable	detectable	JJ
cord-011917-6u0t4hy8	178	6	at	at	IN
cord-011917-6u0t4hy8	178	7	low	low	JJ
cord-011917-6u0t4hy8	178	8	levels	level	NNS
cord-011917-6u0t4hy8	178	9	at	at	IN
cord-011917-6u0t4hy8	178	10	day	day	NN
cord-011917-6u0t4hy8	178	11	seven	seven	CD
cord-011917-6u0t4hy8	178	12	post	post	NN
cord-011917-6u0t4hy8	178	13	-	-	NN
cord-011917-6u0t4hy8	178	14	infection	infection	NN
cord-011917-6u0t4hy8	178	15	.	.	.
cord-011917-6u0t4hy8	179	1	Assessment	assessment	NN
cord-011917-6u0t4hy8	179	2	of	of	IN
cord-011917-6u0t4hy8	179	3	the	the	DT
cord-011917-6u0t4hy8	179	4	ferret	ferret	NN
cord-011917-6u0t4hy8	179	5	transcriptome	transcriptome	NN
cord-011917-6u0t4hy8	179	6	during	during	IN
cord-011917-6u0t4hy8	179	7	this	this	DT
cord-011917-6u0t4hy8	179	8	challenge	challenge	NN
cord-011917-6u0t4hy8	179	9	provided	provide	VBD
cord-011917-6u0t4hy8	179	10	invaluable	invaluable	JJ
cord-011917-6u0t4hy8	179	11	data	datum	NNS
cord-011917-6u0t4hy8	179	12	for	for	IN
cord-011917-6u0t4hy8	179	13	unraveling	unravel	VBG
cord-011917-6u0t4hy8	179	14	the	the	DT
cord-011917-6u0t4hy8	179	15	immune	immune	JJ
cord-011917-6u0t4hy8	179	16	response	response	NN
cord-011917-6u0t4hy8	179	17	to	to	IN
cord-011917-6u0t4hy8	179	18	infection	infection	NN
cord-011917-6u0t4hy8	179	19	.	.	.
cord-011917-6u0t4hy8	180	1	In	in	IN
cord-011917-6u0t4hy8	180	2	a	a	DT
cord-011917-6u0t4hy8	180	3	primary	primary	JJ
cord-011917-6u0t4hy8	180	4	challenge	challenge	NN
cord-011917-6u0t4hy8	180	5	,	,	,
cord-011917-6u0t4hy8	180	6	innate	innate	JJ
cord-011917-6u0t4hy8	180	7	immune	immune	JJ
cord-011917-6u0t4hy8	180	8	system	system	NN
cord-011917-6u0t4hy8	180	9	and	and	CC
cord-011917-6u0t4hy8	180	10	inflammatory	inflammatory	JJ
cord-011917-6u0t4hy8	180	11	genes	gene	NNS
cord-011917-6u0t4hy8	180	12	were	be	VBD
cord-011917-6u0t4hy8	180	13	upregulated	upregulate	VBN
cord-011917-6u0t4hy8	180	14	in	in	IN
cord-011917-6u0t4hy8	180	15	both	both	CC
cord-011917-6u0t4hy8	180	16	the	the	DT
cord-011917-6u0t4hy8	180	17	lung	lung	NN
cord-011917-6u0t4hy8	180	18	and	and	CC
cord-011917-6u0t4hy8	180	19	lymph	lymph	NN
cord-011917-6u0t4hy8	180	20	node	node	NN
cord-011917-6u0t4hy8	180	21	tissues	tissue	NNS
cord-011917-6u0t4hy8	180	22	.	.	.
cord-011917-6u0t4hy8	181	1	Comparatively	comparatively	RB
cord-011917-6u0t4hy8	181	2	,	,	,
cord-011917-6u0t4hy8	181	3	in	in	IN
cord-011917-6u0t4hy8	181	4	the	the	DT
cord-011917-6u0t4hy8	181	5	pre	pre	JJ
cord-011917-6u0t4hy8	181	6	-	-	JJ
cord-011917-6u0t4hy8	181	7	immune	immune	JJ
cord-011917-6u0t4hy8	181	8	ferret	ferret	NN
cord-011917-6u0t4hy8	181	9	,	,	,
cord-011917-6u0t4hy8	181	10	the	the	DT
cord-011917-6u0t4hy8	181	11	adaptive	adaptive	JJ
cord-011917-6u0t4hy8	181	12	immune	immune	JJ
cord-011917-6u0t4hy8	181	13	response	response	NN
cord-011917-6u0t4hy8	181	14	genes	gene	NNS
cord-011917-6u0t4hy8	181	15	(	(	-LRB-
cord-011917-6u0t4hy8	181	16	CXCL10	CXCL10	NNP
cord-011917-6u0t4hy8	181	17	,	,	,
cord-011917-6u0t4hy8	181	18	CCL5	CCL5	NNP
cord-011917-6u0t4hy8	181	19	)	)	-RRB-
cord-011917-6u0t4hy8	181	20	were	be	VBD
cord-011917-6u0t4hy8	181	21	upregulated	upregulate	VBN
cord-011917-6u0t4hy8	181	22	in	in	IN
cord-011917-6u0t4hy8	181	23	the	the	DT
cord-011917-6u0t4hy8	181	24	lungs	lung	NNS
cord-011917-6u0t4hy8	181	25	,	,	,
cord-011917-6u0t4hy8	181	26	with	with	IN
cord-011917-6u0t4hy8	181	27	no	no	DT
cord-011917-6u0t4hy8	181	28	upregulation	upregulation	NN
cord-011917-6u0t4hy8	181	29	in	in	IN
cord-011917-6u0t4hy8	181	30	the	the	DT
cord-011917-6u0t4hy8	181	31	lymph	lymph	NN
cord-011917-6u0t4hy8	181	32	nodes	node	NNS
cord-011917-6u0t4hy8	181	33	.	.	.
cord-011917-6u0t4hy8	182	1	The	the	DT
cord-011917-6u0t4hy8	182	2	lack	lack	NN
cord-011917-6u0t4hy8	182	3	of	of	IN
cord-011917-6u0t4hy8	182	4	lymph	lymph	NN
cord-011917-6u0t4hy8	182	5	node	node	NN
cord-011917-6u0t4hy8	182	6	gene	gene	NN
cord-011917-6u0t4hy8	182	7	activity	activity	NN
cord-011917-6u0t4hy8	182	8	suggested	suggest	VBD
cord-011917-6u0t4hy8	182	9	that	that	IN
cord-011917-6u0t4hy8	182	10	influenza	influenza	JJ
cord-011917-6u0t4hy8	182	11	specific	specific	JJ
cord-011917-6u0t4hy8	182	12	CD8	CD8	NNP
cord-011917-6u0t4hy8	182	13	+	+	CC
cord-011917-6u0t4hy8	182	14	T	T	NNP
cord-011917-6u0t4hy8	182	15	-	-	HYPH
cord-011917-6u0t4hy8	182	16	cells	cell	NNS
cord-011917-6u0t4hy8	182	17	and	and	CC
cord-011917-6u0t4hy8	182	18	B	b	NN
cord-011917-6u0t4hy8	182	19	-	-	HYPH
cord-011917-6u0t4hy8	182	20	cells	cell	NNS
cord-011917-6u0t4hy8	182	21	may	may	MD
cord-011917-6u0t4hy8	182	22	have	have	VB
cord-011917-6u0t4hy8	182	23	originally	originally	RB
cord-011917-6u0t4hy8	182	24	resided	reside	VBN
cord-011917-6u0t4hy8	182	25	within	within	IN
cord-011917-6u0t4hy8	182	26	the	the	DT
cord-011917-6u0t4hy8	182	27	lungs	lung	NNS
cord-011917-6u0t4hy8	182	28	before	before	IN
cord-011917-6u0t4hy8	182	29	infection	infection	NN
cord-011917-6u0t4hy8	182	30	or	or	CC
cord-011917-6u0t4hy8	182	31	the	the	DT
cord-011917-6u0t4hy8	182	32	adaptive	adaptive	JJ
cord-011917-6u0t4hy8	182	33	immune	immune	JJ
cord-011917-6u0t4hy8	182	34	response	response	NN
cord-011917-6u0t4hy8	182	35	originated	originate	VBD
cord-011917-6u0t4hy8	182	36	from	from	IN
cord-011917-6u0t4hy8	182	37	another	another	DT
cord-011917-6u0t4hy8	182	38	unidentified	unidentified	JJ
cord-011917-6u0t4hy8	182	39	peripheral	peripheral	JJ
cord-011917-6u0t4hy8	182	40	compartment	compartment	NN
cord-011917-6u0t4hy8	182	41	[	[	-LRB-
cord-011917-6u0t4hy8	182	42	87	87	CD
cord-011917-6u0t4hy8	182	43	]	]	-RRB-
cord-011917-6u0t4hy8	182	44	.	.	.
cord-011917-6u0t4hy8	183	1	Influenza	influenza	NN
cord-011917-6u0t4hy8	183	2	virus	virus	NN
cord-011917-6u0t4hy8	183	3	infection	infection	NN
cord-011917-6u0t4hy8	183	4	also	also	RB
cord-011917-6u0t4hy8	183	5	imprints	imprint	VBZ
cord-011917-6u0t4hy8	183	6	on	on	IN
cord-011917-6u0t4hy8	183	7	the	the	DT
cord-011917-6u0t4hy8	183	8	influenza	influenza	NN
cord-011917-6u0t4hy8	183	9	-	-	HYPH
cord-011917-6u0t4hy8	183	10	specific	specific	JJ
cord-011917-6u0t4hy8	183	11	T	t	NN
cord-011917-6u0t4hy8	183	12	-	-	HYPH
cord-011917-6u0t4hy8	183	13	cell	cell	NN
cord-011917-6u0t4hy8	183	14	memory	memory	NN
cord-011917-6u0t4hy8	183	15	compartment	compartment	NN
cord-011917-6u0t4hy8	183	16	.	.	.
cord-011917-6u0t4hy8	184	1	In	in	IN
cord-011917-6u0t4hy8	184	2	an	an	DT
cord-011917-6u0t4hy8	184	3	A(H1N1)/A(H1N1	a(h1n1)/a(h1n1	NN
cord-011917-6u0t4hy8	184	4	)	)	-RRB-
cord-011917-6u0t4hy8	184	5	homologous	homologous	JJ
cord-011917-6u0t4hy8	184	6	and	and	CC
cord-011917-6u0t4hy8	184	7	an	an	DT
cord-011917-6u0t4hy8	184	8	A(H1N1)/A(H3N2	a(h1n1)/a(h3n2	NN
cord-011917-6u0t4hy8	184	9	)	)	-RRB-
cord-011917-6u0t4hy8	185	1	heterologous	heterologous	NNP
cord-011917-6u0t4hy8	185	2	challenge	challenge	NN
cord-011917-6u0t4hy8	185	3	,	,	,
cord-011917-6u0t4hy8	185	4	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	185	5	)	)	-RRB-
cord-011917-6u0t4hy8	185	6	imprinting	imprinting	NN
cord-011917-6u0t4hy8	185	7	partially	partially	RB
cord-011917-6u0t4hy8	185	8	protected	protect	VBN
cord-011917-6u0t4hy8	185	9	against	against	IN
cord-011917-6u0t4hy8	185	10	the	the	DT
cord-011917-6u0t4hy8	185	11	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	185	12	)	)	-RRB-
cord-011917-6u0t4hy8	185	13	challenge	challenge	NN
cord-011917-6u0t4hy8	185	14	,	,	,
cord-011917-6u0t4hy8	185	15	reducing	reduce	VBG
cord-011917-6u0t4hy8	185	16	virus	virus	NN
cord-011917-6u0t4hy8	185	17	shedding	shed	VBG
cord-011917-6u0t4hy8	185	18	duration	duration	NN
cord-011917-6u0t4hy8	185	19	,	,	,
cord-011917-6u0t4hy8	185	20	but	but	CC
cord-011917-6u0t4hy8	185	21	not	not	RB
cord-011917-6u0t4hy8	185	22	the	the	DT
cord-011917-6u0t4hy8	185	23	peak	peak	JJ
cord-011917-6u0t4hy8	185	24	virus	virus	NN
cord-011917-6u0t4hy8	185	25	titer	titer	NN
cord-011917-6u0t4hy8	185	26	.	.	.
cord-011917-6u0t4hy8	186	1	The	the	DT
cord-011917-6u0t4hy8	186	2	inflammatory	inflammatory	JJ
cord-011917-6u0t4hy8	186	3	immune	immune	JJ
cord-011917-6u0t4hy8	186	4	response	response	NN
cord-011917-6u0t4hy8	186	5	was	be	VBD
cord-011917-6u0t4hy8	186	6	increased	increase	VBN
cord-011917-6u0t4hy8	186	7	,	,	,
cord-011917-6u0t4hy8	186	8	but	but	CC
cord-011917-6u0t4hy8	186	9	less	less	JJR
cord-011917-6u0t4hy8	186	10	than	than	IN
cord-011917-6u0t4hy8	186	11	that	that	DT
cord-011917-6u0t4hy8	186	12	of	of	IN
cord-011917-6u0t4hy8	186	13	the	the	DT
cord-011917-6u0t4hy8	186	14	immunologically	immunologically	RB
cord-011917-6u0t4hy8	186	15	naive	naive	JJ
cord-011917-6u0t4hy8	186	16	infected	infected	JJ
cord-011917-6u0t4hy8	186	17	ferrets	ferret	NNS
cord-011917-6u0t4hy8	186	18	[	[	-LRB-
cord-011917-6u0t4hy8	186	19	88	88	CD
cord-011917-6u0t4hy8	186	20	]	]	-RRB-
cord-011917-6u0t4hy8	186	21	.	.	.
cord-011917-6u0t4hy8	187	1	Differences	difference	NNS
cord-011917-6u0t4hy8	187	2	between	between	IN
cord-011917-6u0t4hy8	187	3	interferon	interferon	NN
cord-011917-6u0t4hy8	187	4	-	-	HYPH
cord-011917-6u0t4hy8	187	5	gamma	gamma	NN
cord-011917-6u0t4hy8	187	6	(	(	-LRB-
cord-011917-6u0t4hy8	187	7	IFN	IFN	NNP
cord-011917-6u0t4hy8	187	8	-	-	HYPH
cord-011917-6u0t4hy8	187	9	γ	γ	NNP
cord-011917-6u0t4hy8	187	10	)	)	-RRB-
cord-011917-6u0t4hy8	187	11	producing	produce	VBG
cord-011917-6u0t4hy8	187	12	peripheral	peripheral	JJ
cord-011917-6u0t4hy8	187	13	blood	blood	NN
cord-011917-6u0t4hy8	187	14	mononuclear	mononuclear	NN
cord-011917-6u0t4hy8	187	15	cells	cell	NNS
cord-011917-6u0t4hy8	187	16	(	(	-LRB-
cord-011917-6u0t4hy8	187	17	PBMCs	pbmc	NNS
cord-011917-6u0t4hy8	187	18	)	)	-RRB-
cord-011917-6u0t4hy8	187	19	in	in	IN
cord-011917-6u0t4hy8	187	20	naïve	naïve	JJ
cord-011917-6u0t4hy8	187	21	vs.	vs.	IN
cord-011917-6u0t4hy8	187	22	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	187	23	)	)	-RRB-
cord-011917-6u0t4hy8	188	1	pre	pre	VB
cord-011917-6u0t4hy8	188	2	-	-	JJ
cord-011917-6u0t4hy8	188	3	immunized	immunize	VBN
cord-011917-6u0t4hy8	188	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	188	5	with	with	IN
cord-011917-6u0t4hy8	188	6	a	a	DT
cord-011917-6u0t4hy8	188	7	homologous	homologous	JJ
cord-011917-6u0t4hy8	188	8	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	188	9	)	)	-RRB-
cord-011917-6u0t4hy8	188	10	challenge	challenge	NN
cord-011917-6u0t4hy8	188	11	were	be	VBD
cord-011917-6u0t4hy8	188	12	not	not	RB
cord-011917-6u0t4hy8	188	13	discernable	discernable	JJ
cord-011917-6u0t4hy8	188	14	.	.	.
cord-011917-6u0t4hy8	189	1	However	however	RB
cord-011917-6u0t4hy8	189	2	,	,	,
cord-011917-6u0t4hy8	189	3	the	the	DT
cord-011917-6u0t4hy8	189	4	pre	pre	JJ
cord-011917-6u0t4hy8	189	5	-	-	JJ
cord-011917-6u0t4hy8	189	6	immune	immune	JJ
cord-011917-6u0t4hy8	189	7	ferrets	ferret	NNS
cord-011917-6u0t4hy8	189	8	had	have	VBD
cord-011917-6u0t4hy8	189	9	IFN	IFN	NNP
cord-011917-6u0t4hy8	189	10	-	-	HYPH
cord-011917-6u0t4hy8	189	11	γ	γ	NN
cord-011917-6u0t4hy8	189	12	producing	produce	VBG
cord-011917-6u0t4hy8	189	13	PBMCs	pbmc	NNS
cord-011917-6u0t4hy8	189	14	that	that	WDT
cord-011917-6u0t4hy8	189	15	were	be	VBD
cord-011917-6u0t4hy8	189	16	stimulated	stimulate	VBN
cord-011917-6u0t4hy8	189	17	by	by	IN
cord-011917-6u0t4hy8	189	18	heterosubtypic	heterosubtypic	JJ
cord-011917-6u0t4hy8	189	19	viruses	virus	NNS
cord-011917-6u0t4hy8	189	20	.	.	.
cord-011917-6u0t4hy8	190	1	The	the	DT
cord-011917-6u0t4hy8	190	2	imprinting	imprinting	NN
cord-011917-6u0t4hy8	190	3	event	event	NN
cord-011917-6u0t4hy8	190	4	did	do	VBD
cord-011917-6u0t4hy8	190	5	not	not	RB
cord-011917-6u0t4hy8	190	6	lessen	lessen	VB
cord-011917-6u0t4hy8	190	7	the	the	DT
cord-011917-6u0t4hy8	190	8	quantity	quantity	NN
cord-011917-6u0t4hy8	190	9	IFN	IFN	NNP
cord-011917-6u0t4hy8	190	10	-	-	HYPH
cord-011917-6u0t4hy8	190	11	γ	γ	NNP
cord-011917-6u0t4hy8	190	12	producing	produce	VBG
cord-011917-6u0t4hy8	190	13	PBMCs	pbmc	NNS
cord-011917-6u0t4hy8	190	14	compared	compare	VBN
cord-011917-6u0t4hy8	190	15	to	to	TO
cord-011917-6u0t4hy8	190	16	mock	mock	VB
cord-011917-6u0t4hy8	190	17	/	/	SYM
cord-011917-6u0t4hy8	190	18	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	190	19	)	)	-RRB-
cord-011917-6u0t4hy8	190	20	infected	infect	VBN
cord-011917-6u0t4hy8	190	21	ferrets	ferret	NNS
cord-011917-6u0t4hy8	190	22	.	.	.
cord-011917-6u0t4hy8	191	1	However	however	RB
cord-011917-6u0t4hy8	191	2	,	,	,
cord-011917-6u0t4hy8	191	3	heterosubtypic	heterosubtypic	NNP
cord-011917-6u0t4hy8	191	4	pre	pre	NN
cord-011917-6u0t4hy8	191	5	-	-	NN
cord-011917-6u0t4hy8	191	6	immunity	immunity	NN
cord-011917-6u0t4hy8	191	7	affected	affect	VBD
cord-011917-6u0t4hy8	191	8	the	the	DT
cord-011917-6u0t4hy8	191	9	reactivity	reactivity	NN
cord-011917-6u0t4hy8	191	10	of	of	IN
cord-011917-6u0t4hy8	191	11	the	the	DT
cord-011917-6u0t4hy8	191	12	IFN	IFN	NNP
cord-011917-6u0t4hy8	191	13	-	-	HYPH
cord-011917-6u0t4hy8	191	14	γ	γ	NNP
cord-011917-6u0t4hy8	191	15	producing	produce	VBG
cord-011917-6u0t4hy8	191	16	lung	lung	NN
cord-011917-6u0t4hy8	191	17	mononuclear	mononuclear	NN
cord-011917-6u0t4hy8	191	18	cells	cell	NNS
cord-011917-6u0t4hy8	191	19	(	(	-LRB-
cord-011917-6u0t4hy8	191	20	MNCs	mnc	NNS
cord-011917-6u0t4hy8	191	21	)	)	-RRB-
cord-011917-6u0t4hy8	191	22	and	and	CC
cord-011917-6u0t4hy8	191	23	induced	induce	VBN
cord-011917-6u0t4hy8	191	24	whole	whole	JJ
cord-011917-6u0t4hy8	191	25	-	-	HYPH
cord-011917-6u0t4hy8	191	26	blood	blood	NN
cord-011917-6u0t4hy8	191	27	IFN	IFN	NNP
cord-011917-6u0t4hy8	191	28	-	-	HYPH
cord-011917-6u0t4hy8	191	29	γ	γ	NNP
cord-011917-6u0t4hy8	191	30	producing	produce	VBG
cord-011917-6u0t4hy8	191	31	cells	cell	NNS
cord-011917-6u0t4hy8	191	32	quicker	quick	RBR
cord-011917-6u0t4hy8	191	33	.	.	.
cord-011917-6u0t4hy8	192	1	A(H1N1)/A(H3N2	a(h1n1)/a(h3n2	LS
cord-011917-6u0t4hy8	192	2	)	)	-RRB-
cord-011917-6u0t4hy8	193	1	pre	pre	JJ
cord-011917-6u0t4hy8	193	2	-	-	JJ
cord-011917-6u0t4hy8	193	3	immune	immune	JJ
cord-011917-6u0t4hy8	193	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	193	5	had	have	VBD
cord-011917-6u0t4hy8	193	6	high	high	JJ
cord-011917-6u0t4hy8	193	7	reactivity	reactivity	NN
cord-011917-6u0t4hy8	193	8	of	of	IN
cord-011917-6u0t4hy8	193	9	IFN	IFN	NNP
cord-011917-6u0t4hy8	193	10	-	-	HYPH
cord-011917-6u0t4hy8	193	11	γ	γ	NNP
cord-011917-6u0t4hy8	193	12	producing	produce	VBG
cord-011917-6u0t4hy8	193	13	lung	lung	NN
cord-011917-6u0t4hy8	193	14	MNCs	mnc	NNS
cord-011917-6u0t4hy8	193	15	to	to	IN
cord-011917-6u0t4hy8	193	16	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	193	17	)	)	-RRB-
cord-011917-6u0t4hy8	193	18	virus	virus	NN
cord-011917-6u0t4hy8	193	19	compared	compare	VBN
cord-011917-6u0t4hy8	193	20	to	to	IN
cord-011917-6u0t4hy8	193	21	A(H1N1)/A(H1N1	a(h1n1)/a(h1n1	NN
cord-011917-6u0t4hy8	193	22	)	)	-RRB-
cord-011917-6u0t4hy8	193	23	ferrets	ferret	NNS
cord-011917-6u0t4hy8	193	24	that	that	WDT
cord-011917-6u0t4hy8	193	25	had	have	VBD
cord-011917-6u0t4hy8	193	26	no	no	DT
cord-011917-6u0t4hy8	193	27	increase	increase	NN
cord-011917-6u0t4hy8	193	28	.	.	.
cord-011917-6u0t4hy8	194	1	Although	although	IN
cord-011917-6u0t4hy8	194	2	,	,	,
cord-011917-6u0t4hy8	194	3	the	the	DT
cord-011917-6u0t4hy8	194	4	classification	classification	NN
cord-011917-6u0t4hy8	194	5	of	of	IN
cord-011917-6u0t4hy8	194	6	these	these	DT
cord-011917-6u0t4hy8	194	7	T	T	NNP
cord-011917-6u0t4hy8	194	8	-	-	HYPH
cord-011917-6u0t4hy8	194	9	cells	cell	NNS
cord-011917-6u0t4hy8	194	10	as	as	IN
cord-011917-6u0t4hy8	194	11	CD8	CD8	NNP
cord-011917-6u0t4hy8	194	12	+	+	CC
cord-011917-6u0t4hy8	194	13	or	or	CC
cord-011917-6u0t4hy8	194	14	CD4	CD4	NNP
cord-011917-6u0t4hy8	194	15	+	+	CC
cord-011917-6u0t4hy8	194	16	was	be	VBD
cord-011917-6u0t4hy8	194	17	not	not	RB
cord-011917-6u0t4hy8	194	18	conducted	conduct	VBN
cord-011917-6u0t4hy8	194	19	as	as	IN
cord-011917-6u0t4hy8	194	20	of	of	IN
cord-011917-6u0t4hy8	194	21	yet	yet	RB
cord-011917-6u0t4hy8	194	22	,	,	,
cord-011917-6u0t4hy8	194	23	pre	pre	JJ
cord-011917-6u0t4hy8	194	24	-	-	JJ
cord-011917-6u0t4hy8	194	25	immune	immune	JJ
cord-011917-6u0t4hy8	194	26	ferrets	ferret	NNS
cord-011917-6u0t4hy8	194	27	can	can	MD
cord-011917-6u0t4hy8	194	28	be	be	VB
cord-011917-6u0t4hy8	194	29	used	use	VBN
cord-011917-6u0t4hy8	194	30	to	to	TO
cord-011917-6u0t4hy8	194	31	model	model	VB
cord-011917-6u0t4hy8	194	32	T	t	NN
cord-011917-6u0t4hy8	194	33	-	-	HYPH
cord-011917-6u0t4hy8	194	34	cell	cell	NN
cord-011917-6u0t4hy8	194	35	population	population	NN
cord-011917-6u0t4hy8	194	36	contributions	contribution	NNS
cord-011917-6u0t4hy8	194	37	to	to	IN
cord-011917-6u0t4hy8	194	38	influenza	influenza	NN
cord-011917-6u0t4hy8	194	39	-	-	HYPH
cord-011917-6u0t4hy8	194	40	specific	specific	JJ
cord-011917-6u0t4hy8	194	41	memory	memory	NN
cord-011917-6u0t4hy8	194	42	and	and	CC
cord-011917-6u0t4hy8	194	43	recognition	recognition	NN
cord-011917-6u0t4hy8	194	44	.	.	.
cord-011917-6u0t4hy8	195	1	Future	future	JJ
cord-011917-6u0t4hy8	195	2	studies	study	NNS
cord-011917-6u0t4hy8	195	3	will	will	MD
cord-011917-6u0t4hy8	195	4	investigate	investigate	VB
cord-011917-6u0t4hy8	195	5	the	the	DT
cord-011917-6u0t4hy8	195	6	different	different	JJ
cord-011917-6u0t4hy8	195	7	cellular	cellular	JJ
cord-011917-6u0t4hy8	195	8	and	and	CC
cord-011917-6u0t4hy8	195	9	humoral	humoral	JJ
cord-011917-6u0t4hy8	195	10	responses	response	NNS
cord-011917-6u0t4hy8	195	11	to	to	IN
cord-011917-6u0t4hy8	195	12	influenza	influenza	NN
cord-011917-6u0t4hy8	195	13	virus	virus	NN
cord-011917-6u0t4hy8	195	14	infection	infection	NN
cord-011917-6u0t4hy8	195	15	and	and	CC
cord-011917-6u0t4hy8	195	16	clarify	clarify	VB
cord-011917-6u0t4hy8	195	17	the	the	DT
cord-011917-6u0t4hy8	195	18	differences	difference	NNS
cord-011917-6u0t4hy8	195	19	between	between	IN
cord-011917-6u0t4hy8	195	20	T	t	NN
cord-011917-6u0t4hy8	195	21	-	-	HYPH
cord-011917-6u0t4hy8	195	22	cell	cell	NN
cord-011917-6u0t4hy8	195	23	subsets	subset	NNS
cord-011917-6u0t4hy8	195	24	.	.	.
cord-011917-6u0t4hy8	196	1	The	the	DT
cord-011917-6u0t4hy8	196	2	study	study	NN
cord-011917-6u0t4hy8	196	3	conducted	conduct	VBN
cord-011917-6u0t4hy8	196	4	by	by	IN
cord-011917-6u0t4hy8	196	5	Hay	Hay	NNP
cord-011917-6u0t4hy8	196	6	et	et	FW
cord-011917-6u0t4hy8	196	7	al	al	NNP
cord-011917-6u0t4hy8	196	8	.	.	.
cord-011917-6u0t4hy8	197	1	[	[	-LRB-
cord-011917-6u0t4hy8	197	2	89	89	CD
cord-011917-6u0t4hy8	197	3	]	]	-RRB-
cord-011917-6u0t4hy8	197	4	analyzed	analyze	VBN
cord-011917-6u0t4hy8	197	5	data	datum	NNS
cord-011917-6u0t4hy8	197	6	derived	derive	VBN
cord-011917-6u0t4hy8	197	7	from	from	IN
cord-011917-6u0t4hy8	197	8	a	a	DT
cord-011917-6u0t4hy8	197	9	previous	previous	JJ
cord-011917-6u0t4hy8	197	10	study	study	NN
cord-011917-6u0t4hy8	197	11	[	[	-LRB-
cord-011917-6u0t4hy8	197	12	70	70	CD
cord-011917-6u0t4hy8	197	13	]	]	-RRB-
cord-011917-6u0t4hy8	197	14	to	to	TO
cord-011917-6u0t4hy8	197	15	mathematically	mathematically	RB
cord-011917-6u0t4hy8	197	16	model	model	VB
cord-011917-6u0t4hy8	197	17	the	the	DT
cord-011917-6u0t4hy8	197	18	short	short	JJ
cord-011917-6u0t4hy8	197	19	-	-	HYPH
cord-011917-6u0t4hy8	197	20	term	term	NN
cord-011917-6u0t4hy8	197	21	antibody	antibody	NN
cord-011917-6u0t4hy8	197	22	kinetics	kinetics	NN
cord-011917-6u0t4hy8	197	23	from	from	IN
cord-011917-6u0t4hy8	197	24	either	either	DT
cord-011917-6u0t4hy8	197	25	influenza	influenza	NN
cord-011917-6u0t4hy8	197	26	infection	infection	NN
cord-011917-6u0t4hy8	197	27	or	or	CC
cord-011917-6u0t4hy8	197	28	vaccination	vaccination	NN
cord-011917-6u0t4hy8	197	29	with	with	IN
cord-011917-6u0t4hy8	197	30	and	and	CC
cord-011917-6u0t4hy8	197	31	without	without	IN
cord-011917-6u0t4hy8	197	32	adjuvant	adjuvant	JJ
cord-011917-6u0t4hy8	197	33	.	.	.
cord-011917-6u0t4hy8	198	1	Their	-PRON-	PRP$
cord-011917-6u0t4hy8	198	2	results	result	NNS
cord-011917-6u0t4hy8	198	3	,	,	,
cord-011917-6u0t4hy8	198	4	although	although	IN
cord-011917-6u0t4hy8	198	5	limited	limit	VBN
cord-011917-6u0t4hy8	198	6	in	in	IN
cord-011917-6u0t4hy8	198	7	sample	sample	NN
cord-011917-6u0t4hy8	198	8	size	size	NN
cord-011917-6u0t4hy8	198	9	,	,	,
cord-011917-6u0t4hy8	198	10	highlight	highlight	VB
cord-011917-6u0t4hy8	198	11	the	the	DT
cord-011917-6u0t4hy8	198	12	potential	potential	JJ
cord-011917-6u0t4hy8	198	13	future	future	JJ
cord-011917-6u0t4hy8	198	14	applications	application	NNS
cord-011917-6u0t4hy8	198	15	and	and	CC
cord-011917-6u0t4hy8	198	16	data	datum	NNS
cord-011917-6u0t4hy8	198	17	analysis	analysis	NN
cord-011917-6u0t4hy8	198	18	of	of	IN
cord-011917-6u0t4hy8	198	19	the	the	DT
cord-011917-6u0t4hy8	198	20	serological	serological	JJ
cord-011917-6u0t4hy8	198	21	,	,	,
cord-011917-6u0t4hy8	198	22	cellular	cellular	JJ
cord-011917-6u0t4hy8	198	23	,	,	,
cord-011917-6u0t4hy8	198	24	and	and	CC
cord-011917-6u0t4hy8	198	25	virological	virological	JJ
cord-011917-6u0t4hy8	198	26	data	datum	NNS
cord-011917-6u0t4hy8	198	27	that	that	WDT
cord-011917-6u0t4hy8	198	28	can	can	MD
cord-011917-6u0t4hy8	198	29	be	be	VB
cord-011917-6u0t4hy8	198	30	collected	collect	VBN
cord-011917-6u0t4hy8	198	31	during	during	IN
cord-011917-6u0t4hy8	198	32	a	a	DT
cord-011917-6u0t4hy8	198	33	pre	pre	JJ
cord-011917-6u0t4hy8	198	34	-	-	JJ
cord-011917-6u0t4hy8	198	35	immune	immune	JJ
cord-011917-6u0t4hy8	198	36	study	study	NN
cord-011917-6u0t4hy8	198	37	.	.	.
cord-011917-6u0t4hy8	199	1	The	the	DT
cord-011917-6u0t4hy8	199	2	effects	effect	NNS
cord-011917-6u0t4hy8	199	3	of	of	IN
cord-011917-6u0t4hy8	199	4	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	199	5	)	)	-RRB-
cord-011917-6u0t4hy8	199	6	and	and	CC
cord-011917-6u0t4hy8	199	7	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	199	8	)	)	-RRB-
cord-011917-6u0t4hy8	199	9	pre	pre	JJ
cord-011917-6u0t4hy8	199	10	-	-	NN
cord-011917-6u0t4hy8	199	11	immunity	immunity	NN
cord-011917-6u0t4hy8	199	12	on	on	IN
cord-011917-6u0t4hy8	199	13	the	the	DT
cord-011917-6u0t4hy8	199	14	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	199	15	)	)	-RRB-
cord-011917-6u0t4hy8	199	16	subtype	subtype	NN
cord-011917-6u0t4hy8	199	17	or	or	CC
cord-011917-6u0t4hy8	199	18	the	the	DT
cord-011917-6u0t4hy8	199	19	effect	effect	NN
cord-011917-6u0t4hy8	199	20	of	of	IN
cord-011917-6u0t4hy8	199	21	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	199	22	)	)	-RRB-
cord-011917-6u0t4hy8	199	23	on	on	IN
cord-011917-6u0t4hy8	199	24	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	199	25	)	)	-RRB-
cord-011917-6u0t4hy8	199	26	or	or	CC
cord-011917-6u0t4hy8	199	27	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	199	28	)	)	-RRB-
cord-011917-6u0t4hy8	199	29	vaccination	vaccination	NN
cord-011917-6u0t4hy8	199	30	or	or	CC
cord-011917-6u0t4hy8	199	31	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	199	32	viral	viral	JJ
cord-011917-6u0t4hy8	199	33	challenge	challenge	NN
cord-011917-6u0t4hy8	199	34	are	be	VBP
cord-011917-6u0t4hy8	199	35	not	not	RB
cord-011917-6u0t4hy8	199	36	well	well	RB
cord-011917-6u0t4hy8	199	37	known	known	JJ
cord-011917-6u0t4hy8	199	38	.	.	.
cord-011917-6u0t4hy8	200	1	Although	although	IN
cord-011917-6u0t4hy8	200	2	studies	study	NNS
cord-011917-6u0t4hy8	200	3	have	have	VBP
cord-011917-6u0t4hy8	200	4	been	be	VBN
cord-011917-6u0t4hy8	200	5	performed	perform	VBN
cord-011917-6u0t4hy8	200	6	in	in	IN
cord-011917-6u0t4hy8	200	7	pre	pre	JJ
cord-011917-6u0t4hy8	200	8	-	-	JJ
cord-011917-6u0t4hy8	200	9	immune	immune	JJ
cord-011917-6u0t4hy8	200	10	mice	mouse	NNS
cord-011917-6u0t4hy8	200	11	[	[	-LRB-
cord-011917-6u0t4hy8	200	12	90	90	CD
cord-011917-6u0t4hy8	200	13	,	,	,
cord-011917-6u0t4hy8	200	14	91	91	CD
cord-011917-6u0t4hy8	200	15	]	]	-RRB-
cord-011917-6u0t4hy8	200	16	,	,	,
cord-011917-6u0t4hy8	200	17	few	few	JJ
cord-011917-6u0t4hy8	200	18	studies	study	NNS
cord-011917-6u0t4hy8	200	19	have	have	VBP
cord-011917-6u0t4hy8	200	20	addressed	address	VBN
cord-011917-6u0t4hy8	200	21	pre	pre	JJ
cord-011917-6u0t4hy8	200	22	-	-	NN
cord-011917-6u0t4hy8	200	23	immunity	immunity	NN
cord-011917-6u0t4hy8	200	24	using	use	VBG
cord-011917-6u0t4hy8	200	25	the	the	DT
cord-011917-6u0t4hy8	200	26	viruses	virus	NNS
cord-011917-6u0t4hy8	200	27	of	of	IN
cord-011917-6u0t4hy8	200	28	the	the	DT
cord-011917-6u0t4hy8	200	29	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	200	30	)	)	-RRB-
cord-011917-6u0t4hy8	200	31	subtype	subtype	NN
cord-011917-6u0t4hy8	200	32	[	[	-LRB-
cord-011917-6u0t4hy8	200	33	92	92	CD
cord-011917-6u0t4hy8	200	34	]	]	-RRB-
cord-011917-6u0t4hy8	201	1	(	(	-LRB-
cord-011917-6u0t4hy8	201	2	Table	Table	NNP
cord-011917-6u0t4hy8	201	3	S4	S4	NNP
cord-011917-6u0t4hy8	201	4	)	)	-RRB-
cord-011917-6u0t4hy8	201	5	.	.	.
cord-011917-6u0t4hy8	202	1	Pre	pre	JJ
cord-011917-6u0t4hy8	202	2	-	-	JJ
cord-011917-6u0t4hy8	202	3	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	202	4	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	202	5	for	for	IN
cord-011917-6u0t4hy8	202	6	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	202	7	)	)	-RRB-
cord-011917-6u0t4hy8	202	8	influenza	influenza	NN
cord-011917-6u0t4hy8	202	9	viruses	virus	NNS
cord-011917-6u0t4hy8	202	10	elicited	elicit	VBD
cord-011917-6u0t4hy8	202	11	low	low	JJ
cord-011917-6u0t4hy8	202	12	seroconversion	seroconversion	NN
cord-011917-6u0t4hy8	202	13	proportions	proportion	NNS
cord-011917-6u0t4hy8	202	14	in	in	IN
cord-011917-6u0t4hy8	202	15	immunologically	immunologically	RB
cord-011917-6u0t4hy8	202	16	naïve	naïve	JJ
cord-011917-6u0t4hy8	202	17	ferrets	ferret	NNS
cord-011917-6u0t4hy8	202	18	.	.	.
cord-011917-6u0t4hy8	203	1	When	when	WRB
cord-011917-6u0t4hy8	203	2	primed	prime	VBN
cord-011917-6u0t4hy8	203	3	with	with	IN
cord-011917-6u0t4hy8	203	4	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	203	5	live	live	JJ
cord-011917-6u0t4hy8	203	6	attenuated	attenuate	VBN
cord-011917-6u0t4hy8	203	7	influenza	influenza	NN
cord-011917-6u0t4hy8	203	8	vaccine	vaccine	NN
cord-011917-6u0t4hy8	203	9	(	(	-LRB-
cord-011917-6u0t4hy8	203	10	LAIV	LAIV	NNP
cord-011917-6u0t4hy8	203	11	)	)	-RRB-
cord-011917-6u0t4hy8	203	12	,	,	,
cord-011917-6u0t4hy8	203	13	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	203	14	)	)	-RRB-
cord-011917-6u0t4hy8	203	15	HA	HA	NNP
cord-011917-6u0t4hy8	203	16	-	-	HYPH
cord-011917-6u0t4hy8	203	17	specific	specific	JJ
cord-011917-6u0t4hy8	203	18	IgG	igg	NN
cord-011917-6u0t4hy8	203	19	antibody	antibody	NN
cord-011917-6u0t4hy8	203	20	secreting	secrete	VBG
cord-011917-6u0t4hy8	203	21	cells	cell	NNS
cord-011917-6u0t4hy8	203	22	(	(	-LRB-
cord-011917-6u0t4hy8	203	23	ASC	ASC	NNP
cord-011917-6u0t4hy8	203	24	)	)	-RRB-
cord-011917-6u0t4hy8	203	25	were	be	VBD
cord-011917-6u0t4hy8	203	26	stimulated	stimulate	VBN
cord-011917-6u0t4hy8	203	27	compared	compare	VBN
cord-011917-6u0t4hy8	203	28	to	to	IN
cord-011917-6u0t4hy8	203	29	unprimed	unprimed	JJ
cord-011917-6u0t4hy8	203	30	ferrets	ferret	NNS
cord-011917-6u0t4hy8	203	31	.	.	.
cord-011917-6u0t4hy8	204	1	Expansion	expansion	NN
cord-011917-6u0t4hy8	204	2	of	of	IN
cord-011917-6u0t4hy8	204	3	the	the	DT
cord-011917-6u0t4hy8	204	4	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	204	5	)	)	-RRB-
cord-011917-6u0t4hy8	204	6	or	or	CC
cord-011917-6u0t4hy8	204	7	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	204	8	)	)	-RRB-
cord-011917-6u0t4hy8	205	1	specific	specific	JJ
cord-011917-6u0t4hy8	205	2	memory	memory	NN
cord-011917-6u0t4hy8	205	3	B	b	NN
cord-011917-6u0t4hy8	205	4	-	-	HYPH
cord-011917-6u0t4hy8	205	5	cells	cell	NNS
cord-011917-6u0t4hy8	205	6	may	may	MD
cord-011917-6u0t4hy8	205	7	cross	cross	VB
cord-011917-6u0t4hy8	205	8	-	-	VB
cord-011917-6u0t4hy8	205	9	react	react	VB
cord-011917-6u0t4hy8	205	10	with	with	IN
cord-011917-6u0t4hy8	205	11	the	the	DT
cord-011917-6u0t4hy8	205	12	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	205	13	)	)	-RRB-
cord-011917-6u0t4hy8	205	14	HA	HA	NNP
cord-011917-6u0t4hy8	205	15	antigen	antigen	NN
cord-011917-6u0t4hy8	205	16	.	.	.
cord-011917-6u0t4hy8	206	1	When	when	WRB
cord-011917-6u0t4hy8	206	2	imprinted	imprint	VBN
cord-011917-6u0t4hy8	206	3	with	with	IN
cord-011917-6u0t4hy8	206	4	the	the	DT
cord-011917-6u0t4hy8	206	5	individual	individual	JJ
cord-011917-6u0t4hy8	206	6	vaccine	vaccine	NN
cord-011917-6u0t4hy8	206	7	strains	strain	NNS
cord-011917-6u0t4hy8	206	8	,	,	,
cord-011917-6u0t4hy8	206	9	the	the	DT
cord-011917-6u0t4hy8	206	10	IgG	igg	NN
cord-011917-6u0t4hy8	206	11	ASC	ASC	NNP
cord-011917-6u0t4hy8	206	12	levels	level	NNS
cord-011917-6u0t4hy8	206	13	were	be	VBD
cord-011917-6u0t4hy8	206	14	similar	similar	JJ
cord-011917-6u0t4hy8	206	15	to	to	IN
cord-011917-6u0t4hy8	206	16	the	the	DT
cord-011917-6u0t4hy8	206	17	LAIV	LAIV	NNP
cord-011917-6u0t4hy8	206	18	imprinted	imprint	VBN
cord-011917-6u0t4hy8	206	19	cells	cell	NNS
cord-011917-6u0t4hy8	206	20	,	,	,
cord-011917-6u0t4hy8	206	21	with	with	IN
cord-011917-6u0t4hy8	206	22	the	the	DT
cord-011917-6u0t4hy8	206	23	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	206	24	)	)	-RRB-
cord-011917-6u0t4hy8	207	1	imprinting	imprint	VBG
cord-011917-6u0t4hy8	207	2	influenza	influenza	NN
cord-011917-6u0t4hy8	207	3	virus	virus	NN
cord-011917-6u0t4hy8	207	4	eliciting	elicit	VBG
cord-011917-6u0t4hy8	207	5	higher	high	JJR
cord-011917-6u0t4hy8	207	6	responses	response	NNS
cord-011917-6u0t4hy8	207	7	than	than	IN
cord-011917-6u0t4hy8	207	8	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	207	9	)	)	-RRB-
cord-011917-6u0t4hy8	207	10	imprinting	imprinting	NN
cord-011917-6u0t4hy8	207	11	viruses	virus	NNS
cord-011917-6u0t4hy8	207	12	.	.	.
cord-011917-6u0t4hy8	208	1	This	this	DT
cord-011917-6u0t4hy8	208	2	effect	effect	NN
cord-011917-6u0t4hy8	208	3	may	may	MD
cord-011917-6u0t4hy8	208	4	be	be	VB
cord-011917-6u0t4hy8	208	5	a	a	DT
cord-011917-6u0t4hy8	208	6	response	response	NN
cord-011917-6u0t4hy8	208	7	to	to	IN
cord-011917-6u0t4hy8	208	8	the	the	DT
cord-011917-6u0t4hy8	208	9	HA	HA	NNP
cord-011917-6u0t4hy8	208	10	molecule	molecule	NN
cord-011917-6u0t4hy8	208	11	rather	rather	RB
cord-011917-6u0t4hy8	208	12	than	than	IN
cord-011917-6u0t4hy8	208	13	the	the	DT
cord-011917-6u0t4hy8	208	14	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	208	15	)	)	-RRB-
cord-011917-6u0t4hy8	209	1	NA	NA	NNP
cord-011917-6u0t4hy8	209	2	protein	protein	NN
cord-011917-6u0t4hy8	210	1	because	because	IN
cord-011917-6u0t4hy8	210	2	an	an	DT
cord-011917-6u0t4hy8	210	3	A(H1N2	A(H1N2	NNP
cord-011917-6u0t4hy8	210	4	)	)	-RRB-
cord-011917-6u0t4hy8	210	5	reassortant	reassortant	JJ
cord-011917-6u0t4hy8	210	6	virus	virus	NN
cord-011917-6u0t4hy8	210	7	elicited	elicit	VBD
cord-011917-6u0t4hy8	210	8	a	a	DT
cord-011917-6u0t4hy8	210	9	similar	similar	JJ
cord-011917-6u0t4hy8	210	10	response	response	NN
cord-011917-6u0t4hy8	210	11	.	.	.
cord-011917-6u0t4hy8	211	1	But	but	CC
cord-011917-6u0t4hy8	211	2	a	a	DT
cord-011917-6u0t4hy8	211	3	synergistic	synergistic	JJ
cord-011917-6u0t4hy8	211	4	or	or	CC
cord-011917-6u0t4hy8	211	5	additive	additive	NN
cord-011917-6u0t4hy8	211	6	effect	effect	NN
cord-011917-6u0t4hy8	211	7	was	be	VBD
cord-011917-6u0t4hy8	211	8	not	not	RB
cord-011917-6u0t4hy8	211	9	determined	determine	VBN
cord-011917-6u0t4hy8	211	10	with	with	IN
cord-011917-6u0t4hy8	211	11	an	an	DT
cord-011917-6u0t4hy8	211	12	A(HXN1	a(hxn1	NN
cord-011917-6u0t4hy8	211	13	)	)	-RRB-
cord-011917-6u0t4hy8	211	14	reassortant	reassortant	JJ
cord-011917-6u0t4hy8	211	15	virus	virus	NN
cord-011917-6u0t4hy8	211	16	to	to	TO
cord-011917-6u0t4hy8	211	17	confirm	confirm	VB
cord-011917-6u0t4hy8	211	18	the	the	DT
cord-011917-6u0t4hy8	211	19	lack	lack	NN
cord-011917-6u0t4hy8	211	20	of	of	IN
cord-011917-6u0t4hy8	211	21	protective	protective	JJ
cord-011917-6u0t4hy8	211	22	contribution	contribution	NN
cord-011917-6u0t4hy8	211	23	from	from	IN
cord-011917-6u0t4hy8	211	24	the	the	DT
cord-011917-6u0t4hy8	211	25	NA	NA	NNP
cord-011917-6u0t4hy8	211	26	.	.	.
cord-011917-6u0t4hy8	212	1	However	however	RB
cord-011917-6u0t4hy8	212	2	,	,	,
cord-011917-6u0t4hy8	212	3	upon	upon	IN
cord-011917-6u0t4hy8	212	4	closer	close	JJR
cord-011917-6u0t4hy8	212	5	inspection	inspection	NN
cord-011917-6u0t4hy8	212	6	,	,	,
cord-011917-6u0t4hy8	212	7	the	the	DT
cord-011917-6u0t4hy8	212	8	protection	protection	NN
cord-011917-6u0t4hy8	212	9	afforded	afford	VBN
cord-011917-6u0t4hy8	212	10	by	by	IN
cord-011917-6u0t4hy8	212	11	the	the	DT
cord-011917-6u0t4hy8	212	12	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	212	13	)	)	-RRB-
cord-011917-6u0t4hy8	213	1	HA	HA	NNP
cord-011917-6u0t4hy8	213	2	was	be	VBD
cord-011917-6u0t4hy8	213	3	temporary	temporary	JJ
cord-011917-6u0t4hy8	213	4	and	and	CC
cord-011917-6u0t4hy8	213	5	waned	wane	VBD
cord-011917-6u0t4hy8	213	6	to	to	IN
cord-011917-6u0t4hy8	213	7	levels	level	NNS
cord-011917-6u0t4hy8	213	8	similar	similar	JJ
cord-011917-6u0t4hy8	213	9	to	to	IN
cord-011917-6u0t4hy8	213	10	naïve	naïve	JJ
cord-011917-6u0t4hy8	213	11	ferrets	ferret	NNS
cord-011917-6u0t4hy8	213	12	three	three	CD
cord-011917-6u0t4hy8	213	13	weeks	week	NNS
cord-011917-6u0t4hy8	213	14	after	after	IN
cord-011917-6u0t4hy8	213	15	the	the	DT
cord-011917-6u0t4hy8	213	16	second	second	JJ
cord-011917-6u0t4hy8	213	17	dose	dose	NN
cord-011917-6u0t4hy8	213	18	was	be	VBD
cord-011917-6u0t4hy8	213	19	administered	administer	VBN
cord-011917-6u0t4hy8	213	20	.	.	.
cord-011917-6u0t4hy8	214	1	Other	other	JJ
cord-011917-6u0t4hy8	214	2	animal	animal	NN
cord-011917-6u0t4hy8	214	3	models	model	NNS
cord-011917-6u0t4hy8	214	4	are	be	VBP
cord-011917-6u0t4hy8	214	5	used	use	VBN
cord-011917-6u0t4hy8	214	6	to	to	TO
cord-011917-6u0t4hy8	214	7	study	study	VB
cord-011917-6u0t4hy8	214	8	influenza	influenza	NN
cord-011917-6u0t4hy8	214	9	vaccination	vaccination	NN
cord-011917-6u0t4hy8	214	10	and	and	CC
cord-011917-6u0t4hy8	214	11	infection	infection	NN
cord-011917-6u0t4hy8	214	12	.	.	.
cord-011917-6u0t4hy8	215	1	The	the	DT
cord-011917-6u0t4hy8	215	2	mouse	mouse	NN
cord-011917-6u0t4hy8	215	3	model	model	NN
cord-011917-6u0t4hy8	215	4	is	be	VBZ
cord-011917-6u0t4hy8	215	5	commonly	commonly	RB
cord-011917-6u0t4hy8	215	6	used	use	VBN
cord-011917-6u0t4hy8	215	7	due	due	IN
cord-011917-6u0t4hy8	215	8	to	to	IN
cord-011917-6u0t4hy8	215	9	the	the	DT
cord-011917-6u0t4hy8	215	10	plethora	plethora	NN
cord-011917-6u0t4hy8	215	11	of	of	IN
cord-011917-6u0t4hy8	215	12	genetic	genetic	JJ
cord-011917-6u0t4hy8	215	13	tools	tool	NNS
cord-011917-6u0t4hy8	215	14	and	and	CC
cord-011917-6u0t4hy8	215	15	the	the	DT
cord-011917-6u0t4hy8	215	16	availability	availability	NN
cord-011917-6u0t4hy8	215	17	of	of	IN
cord-011917-6u0t4hy8	215	18	reagents	reagent	NNS
cord-011917-6u0t4hy8	215	19	.	.	.
cord-011917-6u0t4hy8	216	1	In	in	IN
cord-011917-6u0t4hy8	216	2	addition	addition	NN
cord-011917-6u0t4hy8	216	3	,	,	,
cord-011917-6u0t4hy8	216	4	pre	pre	JJ
cord-011917-6u0t4hy8	216	5	-	-	NN
cord-011917-6u0t4hy8	216	6	immunity	immunity	NN
cord-011917-6u0t4hy8	216	7	can	can	MD
cord-011917-6u0t4hy8	216	8	be	be	VB
cord-011917-6u0t4hy8	216	9	established	establish	VBN
cord-011917-6u0t4hy8	216	10	in	in	IN
cord-011917-6u0t4hy8	216	11	the	the	DT
cord-011917-6u0t4hy8	216	12	mouse	mouse	NN
cord-011917-6u0t4hy8	216	13	model	model	NN
cord-011917-6u0t4hy8	216	14	[	[	-LRB-
cord-011917-6u0t4hy8	216	15	23	23	CD
cord-011917-6u0t4hy8	216	16	,	,	,
cord-011917-6u0t4hy8	216	17	76	76	CD
cord-011917-6u0t4hy8	216	18	,	,	,
cord-011917-6u0t4hy8	216	19	78	78	CD
cord-011917-6u0t4hy8	216	20	,	,	,
cord-011917-6u0t4hy8	216	21	91	91	CD
cord-011917-6u0t4hy8	216	22	,	,	,
cord-011917-6u0t4hy8	216	23	[	[	-LRB-
cord-011917-6u0t4hy8	216	24	93	93	CD
cord-011917-6u0t4hy8	216	25	]	]	-RRB-
cord-011917-6u0t4hy8	216	26	[	[	-LRB-
cord-011917-6u0t4hy8	216	27	94	94	CD
cord-011917-6u0t4hy8	216	28	]	]	-RRB-
cord-011917-6u0t4hy8	216	29	[	[	-LRB-
cord-011917-6u0t4hy8	216	30	95	95	CD
cord-011917-6u0t4hy8	216	31	]	]	-RRB-
cord-011917-6u0t4hy8	217	1	[	[	-LRB-
cord-011917-6u0t4hy8	217	2	96	96	CD
cord-011917-6u0t4hy8	217	3	]	]	-RRB-
cord-011917-6u0t4hy8	217	4	.	.	.
cord-011917-6u0t4hy8	218	1	Within	within	IN
cord-011917-6u0t4hy8	218	2	mice	mouse	NNS
cord-011917-6u0t4hy8	218	3	,	,	,
cord-011917-6u0t4hy8	218	4	pre	pre	VBN
cord-011917-6u0t4hy8	218	5	-	-	NN
cord-011917-6u0t4hy8	218	6	infection	infection	NN
cord-011917-6u0t4hy8	218	7	compared	compare	VBN
cord-011917-6u0t4hy8	218	8	to	to	IN
cord-011917-6u0t4hy8	218	9	vaccination	vaccination	NN
cord-011917-6u0t4hy8	218	10	elicited	elicit	VBD
cord-011917-6u0t4hy8	218	11	similar	similar	JJ
cord-011917-6u0t4hy8	218	12	innate	innate	JJ
cord-011917-6u0t4hy8	218	13	immunity	immunity	NN
cord-011917-6u0t4hy8	218	14	and	and	CC
cord-011917-6u0t4hy8	218	15	antibody	antibody	NN
cord-011917-6u0t4hy8	218	16	responses	response	NNS
cord-011917-6u0t4hy8	218	17	.	.	.
cord-011917-6u0t4hy8	219	1	Sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	219	2	immunity	immunity	NN
cord-011917-6u0t4hy8	219	3	was	be	VBD
cord-011917-6u0t4hy8	219	4	achieved	achieve	VBN
cord-011917-6u0t4hy8	219	5	in	in	IN
cord-011917-6u0t4hy8	219	6	pre	pre	JJ
cord-011917-6u0t4hy8	219	7	-	-	JJ
cord-011917-6u0t4hy8	219	8	immune	immune	JJ
cord-011917-6u0t4hy8	219	9	animals	animal	NNS
cord-011917-6u0t4hy8	219	10	that	that	WDT
cord-011917-6u0t4hy8	219	11	had	have	VBD
cord-011917-6u0t4hy8	219	12	reduced	reduce	VBN
cord-011917-6u0t4hy8	219	13	viral	viral	JJ
cord-011917-6u0t4hy8	219	14	receptors	receptor	NNS
cord-011917-6u0t4hy8	219	15	and	and	CC
cord-011917-6u0t4hy8	219	16	increased	increase	VBD
cord-011917-6u0t4hy8	219	17	T	t	NN
cord-011917-6u0t4hy8	219	18	-	-	HYPH
cord-011917-6u0t4hy8	219	19	cell	cell	NN
cord-011917-6u0t4hy8	219	20	responses	response	NNS
cord-011917-6u0t4hy8	219	21	in	in	IN
cord-011917-6u0t4hy8	219	22	the	the	DT
cord-011917-6u0t4hy8	219	23	lungs	lung	NNS
cord-011917-6u0t4hy8	219	24	[	[	-LRB-
cord-011917-6u0t4hy8	219	25	41	41	CD
cord-011917-6u0t4hy8	219	26	]	]	-RRB-
cord-011917-6u0t4hy8	219	27	.	.	.
cord-011917-6u0t4hy8	220	1	Although	although	IN
cord-011917-6u0t4hy8	220	2	less	less	RBR
cord-011917-6u0t4hy8	220	3	utilized	utilize	VBN
cord-011917-6u0t4hy8	220	4	than	than	IN
cord-011917-6u0t4hy8	220	5	mice	mouse	NNS
cord-011917-6u0t4hy8	220	6	or	or	CC
cord-011917-6u0t4hy8	220	7	ferrets	ferret	NNS
cord-011917-6u0t4hy8	220	8	,	,	,
cord-011917-6u0t4hy8	220	9	guinea	guinea	NN
cord-011917-6u0t4hy8	220	10	pigs	pig	NNS
cord-011917-6u0t4hy8	220	11	produce	produce	VBP
cord-011917-6u0t4hy8	220	12	similar	similar	JJ
cord-011917-6u0t4hy8	220	13	results	result	NNS
cord-011917-6u0t4hy8	220	14	[	[	-LRB-
cord-011917-6u0t4hy8	220	15	78	78	CD
cord-011917-6u0t4hy8	220	16	,	,	,
cord-011917-6u0t4hy8	220	17	97	97	CD
cord-011917-6u0t4hy8	220	18	]	]	-RRB-
cord-011917-6u0t4hy8	220	19	.	.	.
cord-011917-6u0t4hy8	221	1	The	the	DT
cord-011917-6u0t4hy8	221	2	main	main	JJ
cord-011917-6u0t4hy8	221	3	hypothesis	hypothesis	NN
cord-011917-6u0t4hy8	221	4	and	and	CC
cord-011917-6u0t4hy8	221	5	question	question	NN
cord-011917-6u0t4hy8	221	6	being	be	VBG
cord-011917-6u0t4hy8	221	7	addressed	address	VBN
cord-011917-6u0t4hy8	221	8	will	will	MD
cord-011917-6u0t4hy8	221	9	determine	determine	VB
cord-011917-6u0t4hy8	221	10	strains	strain	NNS
cord-011917-6u0t4hy8	221	11	selected	select	VBN
cord-011917-6u0t4hy8	221	12	for	for	IN
cord-011917-6u0t4hy8	221	13	use	use	NN
cord-011917-6u0t4hy8	221	14	in	in	IN
cord-011917-6u0t4hy8	221	15	a	a	DT
cord-011917-6u0t4hy8	221	16	pre	pre	JJ
cord-011917-6u0t4hy8	221	17	-	-	JJ
cord-011917-6u0t4hy8	221	18	immune	immune	JJ
cord-011917-6u0t4hy8	221	19	model	model	NN
cord-011917-6u0t4hy8	221	20	.	.	.
cord-011917-6u0t4hy8	222	1	The	the	DT
cord-011917-6u0t4hy8	222	2	priming	priming	NN
cord-011917-6u0t4hy8	222	3	method	method	NN
cord-011917-6u0t4hy8	222	4	,	,	,
cord-011917-6u0t4hy8	222	5	whether	whether	IN
cord-011917-6u0t4hy8	222	6	by	by	IN
cord-011917-6u0t4hy8	222	7	vaccination	vaccination	NN
cord-011917-6u0t4hy8	222	8	or	or	CC
cord-011917-6u0t4hy8	222	9	infection	infection	NN
cord-011917-6u0t4hy8	222	10	should	should	MD
cord-011917-6u0t4hy8	222	11	be	be	VB
cord-011917-6u0t4hy8	222	12	evaluated	evaluate	VBN
cord-011917-6u0t4hy8	222	13	based	base	VBN
cord-011917-6u0t4hy8	222	14	on	on	IN
cord-011917-6u0t4hy8	222	15	the	the	DT
cord-011917-6u0t4hy8	222	16	target	target	NN
cord-011917-6u0t4hy8	222	17	population	population	NN
cord-011917-6u0t4hy8	222	18	of	of	IN
cord-011917-6u0t4hy8	222	19	the	the	DT
cord-011917-6u0t4hy8	222	20	vaccine	vaccine	NN
cord-011917-6u0t4hy8	222	21	/	/	SYM
cord-011917-6u0t4hy8	222	22	study	study	NN
cord-011917-6u0t4hy8	222	23	.	.	.
cord-011917-6u0t4hy8	223	1	An	an	DT
cord-011917-6u0t4hy8	223	2	infant	infant	NN
cord-011917-6u0t4hy8	223	3	or	or	CC
cord-011917-6u0t4hy8	223	4	child	child	NN
cord-011917-6u0t4hy8	223	5	target	target	NN
cord-011917-6u0t4hy8	223	6	demographic	demographic	JJ
cord-011917-6u0t4hy8	223	7	may	may	MD
cord-011917-6u0t4hy8	223	8	warrant	warrant	VB
cord-011917-6u0t4hy8	223	9	that	that	IN
cord-011917-6u0t4hy8	223	10	priming	priming	NN
cord-011917-6u0t4hy8	223	11	actually	actually	RB
cord-011917-6u0t4hy8	223	12	occur	occur	VBP
cord-011917-6u0t4hy8	223	13	through	through	IN
cord-011917-6u0t4hy8	223	14	vaccination	vaccination	NN
cord-011917-6u0t4hy8	223	15	followed	follow	VBN
cord-011917-6u0t4hy8	223	16	by	by	IN
cord-011917-6u0t4hy8	223	17	viral	viral	JJ
cord-011917-6u0t4hy8	223	18	challenge	challenge	NN
cord-011917-6u0t4hy8	223	19	.	.	.
cord-011917-6u0t4hy8	224	1	This	this	DT
cord-011917-6u0t4hy8	224	2	instance	instance	NN
cord-011917-6u0t4hy8	224	3	recapitulates	recapitulate	VBZ
cord-011917-6u0t4hy8	224	4	if	if	IN
cord-011917-6u0t4hy8	224	5	the	the	DT
cord-011917-6u0t4hy8	224	6	vaccine	vaccine	NN
cord-011917-6u0t4hy8	224	7	was	be	VBD
cord-011917-6u0t4hy8	224	8	administered	administer	VBN
cord-011917-6u0t4hy8	224	9	before	before	IN
cord-011917-6u0t4hy8	224	10	exposure	exposure	NN
cord-011917-6u0t4hy8	224	11	to	to	IN
cord-011917-6u0t4hy8	224	12	influenza	influenza	NN
cord-011917-6u0t4hy8	224	13	.	.	.
cord-011917-6u0t4hy8	225	1	In	in	IN
cord-011917-6u0t4hy8	225	2	contrast	contrast	NN
cord-011917-6u0t4hy8	225	3	,	,	,
cord-011917-6u0t4hy8	225	4	to	to	TO
cord-011917-6u0t4hy8	225	5	target	target	VB
cord-011917-6u0t4hy8	225	6	populations	population	NNS
cord-011917-6u0t4hy8	225	7	whose	whose	WP$
cord-011917-6u0t4hy8	225	8	first	first	JJ
cord-011917-6u0t4hy8	225	9	exposure	exposure	NN
cord-011917-6u0t4hy8	225	10	is	be	VBZ
cord-011917-6u0t4hy8	225	11	through	through	IN
cord-011917-6u0t4hy8	225	12	infection	infection	NN
cord-011917-6u0t4hy8	225	13	,	,	,
cord-011917-6u0t4hy8	225	14	live	live	JJ
cord-011917-6u0t4hy8	225	15	influenza	influenza	NN
cord-011917-6u0t4hy8	225	16	virus	virus	NN
cord-011917-6u0t4hy8	225	17	would	would	MD
cord-011917-6u0t4hy8	225	18	be	be	VB
cord-011917-6u0t4hy8	225	19	the	the	DT
cord-011917-6u0t4hy8	225	20	appropriate	appropriate	JJ
cord-011917-6u0t4hy8	225	21	priming	priming	NN
cord-011917-6u0t4hy8	225	22	method	method	NN
cord-011917-6u0t4hy8	225	23	.	.	.
cord-011917-6u0t4hy8	226	1	The	the	DT
cord-011917-6u0t4hy8	226	2	initial	initial	JJ
cord-011917-6u0t4hy8	226	3	imprinting	imprinting	NN
cord-011917-6u0t4hy8	226	4	strain	strain	NN
cord-011917-6u0t4hy8	226	5	should	should	MD
cord-011917-6u0t4hy8	226	6	be	be	VB
cord-011917-6u0t4hy8	226	7	antigenically	antigenically	RB
cord-011917-6u0t4hy8	226	8	representative	representative	NN
cord-011917-6u0t4hy8	226	9	for	for	IN
cord-011917-6u0t4hy8	226	10	the	the	DT
cord-011917-6u0t4hy8	226	11	population	population	NN
cord-011917-6u0t4hy8	226	12	being	be	VBG
cord-011917-6u0t4hy8	226	13	modeled	model	VBN
cord-011917-6u0t4hy8	226	14	.	.	.
cord-011917-6u0t4hy8	227	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	227	2	,	,	,
cord-011917-6u0t4hy8	227	3	the	the	DT
cord-011917-6u0t4hy8	227	4	timing	timing	NN
cord-011917-6u0t4hy8	227	5	and	and	CC
cord-011917-6u0t4hy8	227	6	order	order	NN
cord-011917-6u0t4hy8	227	7	of	of	IN
cord-011917-6u0t4hy8	227	8	the	the	DT
cord-011917-6u0t4hy8	227	9	infections	infection	NNS
cord-011917-6u0t4hy8	227	10	are	be	VBP
cord-011917-6u0t4hy8	227	11	variable	variable	JJ
cord-011917-6u0t4hy8	227	12	.	.	.
cord-011917-6u0t4hy8	228	1	After	after	IN
cord-011917-6u0t4hy8	228	2	imprinting	imprinting	NN
cord-011917-6u0t4hy8	228	3	,	,	,
cord-011917-6u0t4hy8	228	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	228	5	may	may	MD
cord-011917-6u0t4hy8	228	6	be	be	VB
cord-011917-6u0t4hy8	228	7	re	re	VBN
cord-011917-6u0t4hy8	228	8	-	-	VBN
cord-011917-6u0t4hy8	228	9	infected	infect	VBN
cord-011917-6u0t4hy8	228	10	to	to	TO
cord-011917-6u0t4hy8	228	11	add	add	VB
cord-011917-6u0t4hy8	228	12	to	to	IN
cord-011917-6u0t4hy8	228	13	the	the	DT
cord-011917-6u0t4hy8	228	14	pre	pre	JJ
cord-011917-6u0t4hy8	228	15	-	-	JJ
cord-011917-6u0t4hy8	228	16	immune	immune	JJ
cord-011917-6u0t4hy8	228	17	history	history	NN
cord-011917-6u0t4hy8	228	18	or	or	CC
cord-011917-6u0t4hy8	228	19	be	be	VB
cord-011917-6u0t4hy8	228	20	vaccinated	vaccinate	VBN
cord-011917-6u0t4hy8	228	21	or	or	CC
cord-011917-6u0t4hy8	228	22	challenged	challenge	VBN
cord-011917-6u0t4hy8	228	23	according	accord	VBG
cord-011917-6u0t4hy8	228	24	to	to	IN
cord-011917-6u0t4hy8	228	25	study	study	VB
cord-011917-6u0t4hy8	228	26	design	design	NN
cord-011917-6u0t4hy8	228	27	.	.	.
cord-011917-6u0t4hy8	229	1	However	however	RB
cord-011917-6u0t4hy8	229	2	,	,	,
cord-011917-6u0t4hy8	229	3	the	the	DT
cord-011917-6u0t4hy8	229	4	magnitude	magnitude	NN
cord-011917-6u0t4hy8	229	5	of	of	IN
cord-011917-6u0t4hy8	229	6	the	the	DT
cord-011917-6u0t4hy8	229	7	contributions	contribution	NNS
cord-011917-6u0t4hy8	229	8	of	of	IN
cord-011917-6u0t4hy8	229	9	a	a	DT
cord-011917-6u0t4hy8	229	10	full	full	JJ
cord-011917-6u0t4hy8	229	11	pre	pre	JJ
cord-011917-6u0t4hy8	229	12	-	-	JJ
cord-011917-6u0t4hy8	229	13	immunity	immunity	JJ
cord-011917-6u0t4hy8	229	14	history	history	NN
cord-011917-6u0t4hy8	229	15	compared	compare	VBN
cord-011917-6u0t4hy8	229	16	to	to	IN
cord-011917-6u0t4hy8	229	17	just	just	RB
cord-011917-6u0t4hy8	229	18	the	the	DT
cord-011917-6u0t4hy8	229	19	initial	initial	JJ
cord-011917-6u0t4hy8	229	20	imprinting	imprinting	NN
cord-011917-6u0t4hy8	229	21	virus	virus	NN
cord-011917-6u0t4hy8	229	22	on	on	IN
cord-011917-6u0t4hy8	229	23	the	the	DT
cord-011917-6u0t4hy8	229	24	immune	immune	JJ
cord-011917-6u0t4hy8	229	25	response	response	NN
cord-011917-6u0t4hy8	229	26	has	have	VBZ
cord-011917-6u0t4hy8	229	27	not	not	RB
cord-011917-6u0t4hy8	229	28	been	be	VBN
cord-011917-6u0t4hy8	229	29	adequately	adequately	RB
cord-011917-6u0t4hy8	229	30	quantified	quantify	VBN
cord-011917-6u0t4hy8	229	31	.	.	.
cord-011917-6u0t4hy8	230	1	For	for	IN
cord-011917-6u0t4hy8	230	2	instance	instance	NN
cord-011917-6u0t4hy8	230	3	,	,	,
cord-011917-6u0t4hy8	230	4	if	if	IN
cord-011917-6u0t4hy8	230	5	attempting	attempt	VBG
cord-011917-6u0t4hy8	230	6	to	to	TO
cord-011917-6u0t4hy8	230	7	recapitulate	recapitulate	VB
cord-011917-6u0t4hy8	230	8	a	a	DT
cord-011917-6u0t4hy8	230	9	person	person	NN
cord-011917-6u0t4hy8	230	10	born	bear	VBN
cord-011917-6u0t4hy8	230	11	in	in	IN
cord-011917-6u0t4hy8	230	12	1970	1970	CD
cord-011917-6u0t4hy8	230	13	,	,	,
cord-011917-6u0t4hy8	230	14	it	-PRON-	PRP
cord-011917-6u0t4hy8	230	15	is	be	VBZ
cord-011917-6u0t4hy8	230	16	unclear	unclear	JJ
cord-011917-6u0t4hy8	230	17	if	if	IN
cord-011917-6u0t4hy8	230	18	it	-PRON-	PRP
cord-011917-6u0t4hy8	230	19	is	be	VBZ
cord-011917-6u0t4hy8	230	20	only	only	RB
cord-011917-6u0t4hy8	230	21	necessary	necessary	JJ
cord-011917-6u0t4hy8	230	22	to	to	TO
cord-011917-6u0t4hy8	230	23	pre	pre	VB
cord-011917-6u0t4hy8	230	24	-	-	VB
cord-011917-6u0t4hy8	230	25	immunize	immunize	VB
cord-011917-6u0t4hy8	230	26	with	with	IN
cord-011917-6u0t4hy8	230	27	an	an	DT
cord-011917-6u0t4hy8	230	28	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	230	29	)	)	-RRB-
cord-011917-6u0t4hy8	230	30	1970s	1970	NNS
cord-011917-6u0t4hy8	230	31	virus	virus	NN
cord-011917-6u0t4hy8	230	32	,	,	,
cord-011917-6u0t4hy8	230	33	followed	follow	VBN
cord-011917-6u0t4hy8	230	34	by	by	IN
cord-011917-6u0t4hy8	230	35	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	230	36	)	)	-RRB-
cord-011917-6u0t4hy8	231	1	influenza	influenza	NN
cord-011917-6u0t4hy8	231	2	virus	virus	NN
cord-011917-6u0t4hy8	231	3	,	,	,
cord-011917-6u0t4hy8	231	4	or	or	CC
cord-011917-6u0t4hy8	231	5	if	if	IN
cord-011917-6u0t4hy8	231	6	all	all	DT
cord-011917-6u0t4hy8	231	7	of	of	IN
cord-011917-6u0t4hy8	231	8	the	the	DT
cord-011917-6u0t4hy8	231	9	antigenically	antigenically	RB
cord-011917-6u0t4hy8	231	10	distinct	distinct	JJ
cord-011917-6u0t4hy8	231	11	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	231	12	)	)	-RRB-
cord-011917-6u0t4hy8	231	13	viruses	virus	NNS
cord-011917-6u0t4hy8	231	14	are	be	VBP
cord-011917-6u0t4hy8	231	15	needed	need	VBN
cord-011917-6u0t4hy8	231	16	to	to	TO
cord-011917-6u0t4hy8	231	17	establish	establish	VB
cord-011917-6u0t4hy8	231	18	a	a	DT
cord-011917-6u0t4hy8	231	19	true	true	JJ
cord-011917-6u0t4hy8	231	20	pre	pre	JJ
cord-011917-6u0t4hy8	231	21	-	-	JJ
cord-011917-6u0t4hy8	231	22	immune	immune	JJ
cord-011917-6u0t4hy8	231	23	state	state	NN
cord-011917-6u0t4hy8	231	24	.	.	.
cord-011917-6u0t4hy8	232	1	Studies	study	NNS
cord-011917-6u0t4hy8	232	2	investigating	investigate	VBG
cord-011917-6u0t4hy8	232	3	the	the	DT
cord-011917-6u0t4hy8	232	4	effects	effect	NNS
cord-011917-6u0t4hy8	232	5	of	of	IN
cord-011917-6u0t4hy8	232	6	heterosubtypic	heterosubtypic	NNP
cord-011917-6u0t4hy8	232	7	and	and	CC
cord-011917-6u0t4hy8	232	8	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	232	9	imprinting	imprinting	NNP
cord-011917-6u0t4hy8	232	10	and	and	CC
cord-011917-6u0t4hy8	232	11	pre	pre	JJ
cord-011917-6u0t4hy8	232	12	-	-	NN
cord-011917-6u0t4hy8	232	13	immunity	immunity	NN
cord-011917-6u0t4hy8	232	14	can	can	MD
cord-011917-6u0t4hy8	232	15	be	be	VB
cord-011917-6u0t4hy8	232	16	expanded	expand	VBN
cord-011917-6u0t4hy8	232	17	to	to	TO
cord-011917-6u0t4hy8	232	18	include	include	VB
cord-011917-6u0t4hy8	232	19	:	:	:
cord-011917-6u0t4hy8	232	20	(	(	-LRB-
cord-011917-6u0t4hy8	232	21	1	1	LS
cord-011917-6u0t4hy8	232	22	)	)	-RRB-
cord-011917-6u0t4hy8	232	23	Type	type	NN
cord-011917-6u0t4hy8	232	24	B	B	NNP
cord-011917-6u0t4hy8	232	25	imprinting	imprinting	NN
cord-011917-6u0t4hy8	232	26	followed	follow	VBN
cord-011917-6u0t4hy8	232	27	by	by	IN
cord-011917-6u0t4hy8	232	28	an	an	DT
cord-011917-6u0t4hy8	232	29	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	232	30	)	)	-RRB-
cord-011917-6u0t4hy8	232	31	or	or	CC
cord-011917-6u0t4hy8	232	32	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	232	33	)	)	-RRB-
cord-011917-6u0t4hy8	232	34	vaccination	vaccination	NN
cord-011917-6u0t4hy8	232	35	or	or	CC
cord-011917-6u0t4hy8	232	36	challenge	challenge	NN
cord-011917-6u0t4hy8	232	37	,	,	,
cord-011917-6u0t4hy8	232	38	(	(	-LRB-
cord-011917-6u0t4hy8	232	39	2	2	LS
cord-011917-6u0t4hy8	232	40	)	)	-RRB-
cord-011917-6u0t4hy8	232	41	A(H2N2	a(h2n2	NN
cord-011917-6u0t4hy8	232	42	)	)	-RRB-
cord-011917-6u0t4hy8	232	43	imprinting	imprinting	NN
cord-011917-6u0t4hy8	232	44	,	,	,
cord-011917-6u0t4hy8	232	45	(	(	-LRB-
cord-011917-6u0t4hy8	232	46	3	3	CD
cord-011917-6u0t4hy8	232	47	)	)	-RRB-
cord-011917-6u0t4hy8	232	48	A(H1N1	a(h1n1	NN
cord-011917-6u0t4hy8	232	49	)	)	-RRB-
cord-011917-6u0t4hy8	232	50	imprinting	imprinting	NN
cord-011917-6u0t4hy8	232	51	and	and	CC
cord-011917-6u0t4hy8	232	52	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	232	53	)	)	-RRB-
cord-011917-6u0t4hy8	232	54	pre	pre	JJ
cord-011917-6u0t4hy8	232	55	-	-	NN
cord-011917-6u0t4hy8	232	56	immunity	immunity	NN
cord-011917-6u0t4hy8	232	57	and	and	CC
cord-011917-6u0t4hy8	232	58	vice	vice	NN
cord-011917-6u0t4hy8	232	59	versa	versa	RB
cord-011917-6u0t4hy8	232	60	on	on	IN
cord-011917-6u0t4hy8	232	61	which	which	WDT
cord-011917-6u0t4hy8	232	62	combination	combination	NN
cord-011917-6u0t4hy8	232	63	results	result	NNS
cord-011917-6u0t4hy8	232	64	in	in	IN
cord-011917-6u0t4hy8	232	65	more	more	JJR
cord-011917-6u0t4hy8	232	66	protection	protection	NN
cord-011917-6u0t4hy8	232	67	against	against	IN
cord-011917-6u0t4hy8	232	68	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	232	69	)	)	-RRB-
cord-011917-6u0t4hy8	232	70	,	,	,
cord-011917-6u0t4hy8	232	71	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	232	72	)	)	-RRB-
cord-011917-6u0t4hy8	232	73	,	,	,
cord-011917-6u0t4hy8	232	74	A(H2N2	A(H2N2	NNP
cord-011917-6u0t4hy8	232	75	)	)	-RRB-
cord-011917-6u0t4hy8	232	76	,	,	,
cord-011917-6u0t4hy8	232	77	or	or	CC
cord-011917-6u0t4hy8	232	78	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	232	79	)	)	-RRB-
cord-011917-6u0t4hy8	232	80	challenge	challenge	NN
cord-011917-6u0t4hy8	232	81	.	.	.
cord-011917-6u0t4hy8	233	1	Limited	limited	JJ
cord-011917-6u0t4hy8	233	2	research	research	NN
cord-011917-6u0t4hy8	233	3	is	be	VBZ
cord-011917-6u0t4hy8	233	4	available	available	JJ
cord-011917-6u0t4hy8	233	5	on	on	IN
cord-011917-6u0t4hy8	233	6	the	the	DT
cord-011917-6u0t4hy8	233	7	serological	serological	JJ
cord-011917-6u0t4hy8	233	8	,	,	,
cord-011917-6u0t4hy8	233	9	cellular	cellular	JJ
cord-011917-6u0t4hy8	233	10	,	,	,
cord-011917-6u0t4hy8	233	11	and	and	CC
cord-011917-6u0t4hy8	233	12	immunological	immunological	JJ
cord-011917-6u0t4hy8	233	13	effects	effect	NNS
cord-011917-6u0t4hy8	233	14	of	of	IN
cord-011917-6u0t4hy8	233	15	infections	infection	NNS
cord-011917-6u0t4hy8	233	16	with	with	IN
cord-011917-6u0t4hy8	233	17	varying	vary	VBG
cord-011917-6u0t4hy8	233	18	infection	infection	NN
cord-011917-6u0t4hy8	233	19	doses	dose	NNS
cord-011917-6u0t4hy8	233	20	,	,	,
cord-011917-6u0t4hy8	233	21	but	but	CC
cord-011917-6u0t4hy8	233	22	there	there	EX
cord-011917-6u0t4hy8	233	23	have	have	VBP
cord-011917-6u0t4hy8	233	24	been	be	VBN
cord-011917-6u0t4hy8	233	25	observed	observe	VBN
cord-011917-6u0t4hy8	233	26	differences	difference	NNS
cord-011917-6u0t4hy8	233	27	[	[	-LRB-
cord-011917-6u0t4hy8	233	28	98	98	CD
cord-011917-6u0t4hy8	233	29	]	]	-RRB-
cord-011917-6u0t4hy8	233	30	.	.	.
cord-011917-6u0t4hy8	234	1	The	the	DT
cord-011917-6u0t4hy8	234	2	immunological	immunological	JJ
cord-011917-6u0t4hy8	234	3	system	system	NN
cord-011917-6u0t4hy8	234	4	should	should	MD
cord-011917-6u0t4hy8	234	5	return	return	VB
cord-011917-6u0t4hy8	234	6	to	to	IN
cord-011917-6u0t4hy8	234	7	the	the	DT
cord-011917-6u0t4hy8	234	8	baseline	baseline	JJ
cord-011917-6u0t4hy8	234	9	immunological	immunological	JJ
cord-011917-6u0t4hy8	234	10	state	state	NN
cord-011917-6u0t4hy8	234	11	before	before	IN
cord-011917-6u0t4hy8	234	12	attempting	attempt	VBG
cord-011917-6u0t4hy8	234	13	another	another	DT
cord-011917-6u0t4hy8	234	14	repeat	repeat	NN
cord-011917-6u0t4hy8	234	15	infection	infection	NN
cord-011917-6u0t4hy8	234	16	or	or	CC
cord-011917-6u0t4hy8	234	17	vaccination	vaccination	NN
cord-011917-6u0t4hy8	234	18	.	.	.
cord-011917-6u0t4hy8	235	1	This	this	DT
cord-011917-6u0t4hy8	235	2	period	period	NN
cord-011917-6u0t4hy8	235	3	should	should	MD
cord-011917-6u0t4hy8	235	4	encompass	encompass	VB
cord-011917-6u0t4hy8	235	5	the	the	DT
cord-011917-6u0t4hy8	235	6	cool	cool	JJ
cord-011917-6u0t4hy8	235	7	-	-	HYPH
cord-011917-6u0t4hy8	235	8	down	down	RP
cord-011917-6u0t4hy8	235	9	time	time	NN
cord-011917-6u0t4hy8	235	10	for	for	IN
cord-011917-6u0t4hy8	235	11	both	both	CC
cord-011917-6u0t4hy8	235	12	the	the	DT
cord-011917-6u0t4hy8	235	13	innate	innate	JJ
cord-011917-6u0t4hy8	235	14	and	and	CC
cord-011917-6u0t4hy8	235	15	adaptive	adaptive	JJ
cord-011917-6u0t4hy8	235	16	immune	immune	JJ
cord-011917-6u0t4hy8	235	17	systems	system	NNS
cord-011917-6u0t4hy8	235	18	,	,	,
cord-011917-6u0t4hy8	235	19	including	include	VBG
cord-011917-6u0t4hy8	235	20	the	the	DT
cord-011917-6u0t4hy8	235	21	induction	induction	NN
cord-011917-6u0t4hy8	235	22	and	and	CC
cord-011917-6u0t4hy8	235	23	contraction	contraction	NN
cord-011917-6u0t4hy8	235	24	of	of	IN
cord-011917-6u0t4hy8	235	25	B	b	NN
cord-011917-6u0t4hy8	235	26	-	-	:
cord-011917-6u0t4hy8	235	27	and	and	CC
cord-011917-6u0t4hy8	235	28	T	T	NNP
cord-011917-6u0t4hy8	235	29	-	-	HYPH
cord-011917-6u0t4hy8	235	30	cells	cell	NNS
cord-011917-6u0t4hy8	235	31	into	into	IN
cord-011917-6u0t4hy8	235	32	their	-PRON-	PRP$
cord-011917-6u0t4hy8	235	33	memory	memory	NN
cord-011917-6u0t4hy8	235	34	states	state	NNS
cord-011917-6u0t4hy8	235	35	.	.	.
cord-011917-6u0t4hy8	236	1	Studies	study	NNS
cord-011917-6u0t4hy8	236	2	similar	similar	JJ
cord-011917-6u0t4hy8	236	3	to	to	IN
cord-011917-6u0t4hy8	236	4	Leon	Leon	NNP
cord-011917-6u0t4hy8	236	5	et	et	NNP
cord-011917-6u0t4hy8	236	6	al	al	NNP
cord-011917-6u0t4hy8	236	7	.	.	.
cord-011917-6u0t4hy8	237	1	[	[	-LRB-
cord-011917-6u0t4hy8	237	2	87	87	CD
cord-011917-6u0t4hy8	237	3	]	]	-RRB-
cord-011917-6u0t4hy8	237	4	are	be	VBP
cord-011917-6u0t4hy8	237	5	of	of	IN
cord-011917-6u0t4hy8	237	6	great	great	JJ
cord-011917-6u0t4hy8	237	7	importance	importance	NN
cord-011917-6u0t4hy8	237	8	for	for	IN
cord-011917-6u0t4hy8	237	9	understanding	understand	VBG
cord-011917-6u0t4hy8	237	10	the	the	DT
cord-011917-6u0t4hy8	237	11	inner	inner	JJ
cord-011917-6u0t4hy8	237	12	workings	working	NNS
cord-011917-6u0t4hy8	237	13	of	of	IN
cord-011917-6u0t4hy8	237	14	the	the	DT
cord-011917-6u0t4hy8	237	15	ferret	ferret	JJ
cord-011917-6u0t4hy8	237	16	immune	immune	JJ
cord-011917-6u0t4hy8	237	17	system	system	NN
cord-011917-6u0t4hy8	237	18	during	during	IN
cord-011917-6u0t4hy8	237	19	imprinting	imprinting	NN
cord-011917-6u0t4hy8	237	20	and	and	CC
cord-011917-6u0t4hy8	237	21	re	re	NN
cord-011917-6u0t4hy8	237	22	-	-	NN
cord-011917-6u0t4hy8	237	23	infection	infection	NN
cord-011917-6u0t4hy8	237	24	.	.	.
cord-011917-6u0t4hy8	238	1	Without	without	IN
cord-011917-6u0t4hy8	238	2	these	these	DT
cord-011917-6u0t4hy8	238	3	studies	study	NNS
cord-011917-6u0t4hy8	238	4	,	,	,
cord-011917-6u0t4hy8	238	5	this	this	DT
cord-011917-6u0t4hy8	238	6	cool	cool	JJ
cord-011917-6u0t4hy8	238	7	-	-	HYPH
cord-011917-6u0t4hy8	238	8	down	down	RP
cord-011917-6u0t4hy8	238	9	component	component	NN
cord-011917-6u0t4hy8	238	10	will	will	MD
cord-011917-6u0t4hy8	238	11	need	need	VB
cord-011917-6u0t4hy8	238	12	to	to	TO
cord-011917-6u0t4hy8	238	13	continuously	continuously	RB
cord-011917-6u0t4hy8	238	14	be	be	VB
cord-011917-6u0t4hy8	238	15	stated	state	VBN
cord-011917-6u0t4hy8	238	16	as	as	IN
cord-011917-6u0t4hy8	238	17	a	a	DT
cord-011917-6u0t4hy8	238	18	study	study	NN
cord-011917-6u0t4hy8	238	19	limitation	limitation	NN
cord-011917-6u0t4hy8	238	20	.	.	.
cord-011917-6u0t4hy8	239	1	For	for	IN
cord-011917-6u0t4hy8	239	2	example	example	NN
cord-011917-6u0t4hy8	239	3	,	,	,
cord-011917-6u0t4hy8	239	4	Pulit	Pulit	NNP
cord-011917-6u0t4hy8	239	5	-	-	HYPH
cord-011917-6u0t4hy8	239	6	Penaloza	Penaloza	NNP
cord-011917-6u0t4hy8	239	7	et	et	NNP
cord-011917-6u0t4hy8	239	8	al	al	NNP
cord-011917-6u0t4hy8	239	9	.	.	.
cord-011917-6u0t4hy8	240	1	[	[	-LRB-
cord-011917-6u0t4hy8	240	2	84	84	CD
cord-011917-6u0t4hy8	240	3	]	]	-RRB-
cord-011917-6u0t4hy8	240	4	indicated	indicate	VBD
cord-011917-6u0t4hy8	240	5	that	that	IN
cord-011917-6u0t4hy8	240	6	a	a	DT
cord-011917-6u0t4hy8	240	7	thirty	thirty	CD
cord-011917-6u0t4hy8	240	8	-	-	HYPH
cord-011917-6u0t4hy8	240	9	one	one	CD
cord-011917-6u0t4hy8	240	10	day	day	NN
cord-011917-6u0t4hy8	240	11	interval	interval	NN
cord-011917-6u0t4hy8	240	12	between	between	IN
cord-011917-6u0t4hy8	240	13	primary	primary	JJ
cord-011917-6u0t4hy8	240	14	and	and	CC
cord-011917-6u0t4hy8	240	15	secondary	secondary	JJ
cord-011917-6u0t4hy8	240	16	challenges	challenge	NNS
cord-011917-6u0t4hy8	240	17	for	for	IN
cord-011917-6u0t4hy8	240	18	their	-PRON-	PRP$
cord-011917-6u0t4hy8	240	19	studies	study	NNS
cord-011917-6u0t4hy8	240	20	may	may	MD
cord-011917-6u0t4hy8	240	21	have	have	VB
cord-011917-6u0t4hy8	240	22	been	be	VBN
cord-011917-6u0t4hy8	240	23	too	too	RB
cord-011917-6u0t4hy8	240	24	short	short	JJ
cord-011917-6u0t4hy8	240	25	,	,	,
cord-011917-6u0t4hy8	240	26	allowing	allow	VBG
cord-011917-6u0t4hy8	240	27	for	for	IN
cord-011917-6u0t4hy8	240	28	elevated	elevated	JJ
cord-011917-6u0t4hy8	240	29	non	non	JJ
cord-011917-6u0t4hy8	240	30	-	-	JJ
cord-011917-6u0t4hy8	240	31	specific	specific	JJ
cord-011917-6u0t4hy8	240	32	innate	innate	JJ
cord-011917-6u0t4hy8	240	33	responses	response	NNS
cord-011917-6u0t4hy8	240	34	from	from	IN
cord-011917-6u0t4hy8	240	35	the	the	DT
cord-011917-6u0t4hy8	240	36	primary	primary	JJ
cord-011917-6u0t4hy8	240	37	infection	infection	NN
cord-011917-6u0t4hy8	240	38	to	to	TO
cord-011917-6u0t4hy8	240	39	affect	affect	VB
cord-011917-6u0t4hy8	240	40	the	the	DT
cord-011917-6u0t4hy8	240	41	secondary	secondary	JJ
cord-011917-6u0t4hy8	240	42	.	.	.
cord-011917-6u0t4hy8	241	1	Without	without	IN
cord-011917-6u0t4hy8	241	2	letting	let	VBG
cord-011917-6u0t4hy8	241	3	the	the	DT
cord-011917-6u0t4hy8	241	4	immune	immune	JJ
cord-011917-6u0t4hy8	241	5	system	system	NN
cord-011917-6u0t4hy8	241	6	return	return	NN
cord-011917-6u0t4hy8	241	7	to	to	IN
cord-011917-6u0t4hy8	241	8	baseline	baseline	NN
cord-011917-6u0t4hy8	241	9	,	,	,
cord-011917-6u0t4hy8	241	10	misrepresentation	misrepresentation	NN
cord-011917-6u0t4hy8	241	11	of	of	IN
cord-011917-6u0t4hy8	241	12	cross	cross	NN
cord-011917-6u0t4hy8	241	13	-	-	NN
cord-011917-6u0t4hy8	241	14	protection	protection	NN
cord-011917-6u0t4hy8	241	15	may	may	MD
cord-011917-6u0t4hy8	241	16	be	be	VB
cord-011917-6u0t4hy8	241	17	observed	observe	VBN
cord-011917-6u0t4hy8	241	18	.	.	.
cord-011917-6u0t4hy8	242	1	Cheng	Cheng	NNP
cord-011917-6u0t4hy8	242	2	et	et	NNP
cord-011917-6u0t4hy8	242	3	al	al	NNP
cord-011917-6u0t4hy8	242	4	.	.	.
cord-011917-6u0t4hy8	243	1	[	[	-LRB-
cord-011917-6u0t4hy8	243	2	92	92	CD
cord-011917-6u0t4hy8	243	3	]	]	-RRB-
cord-011917-6u0t4hy8	243	4	found	find	VBD
cord-011917-6u0t4hy8	243	5	that	that	IN
cord-011917-6u0t4hy8	243	6	the	the	DT
cord-011917-6u0t4hy8	243	7	heterologous	heterologous	JJ
cord-011917-6u0t4hy8	243	8	protective	protective	JJ
cord-011917-6u0t4hy8	243	9	titers	titer	NNS
cord-011917-6u0t4hy8	243	10	waned	wane	VBD
cord-011917-6u0t4hy8	243	11	to	to	IN
cord-011917-6u0t4hy8	243	12	levels	level	NNS
cord-011917-6u0t4hy8	243	13	not	not	RB
cord-011917-6u0t4hy8	243	14	significantly	significantly	RB
cord-011917-6u0t4hy8	243	15	different	different	JJ
cord-011917-6u0t4hy8	243	16	than	than	IN
cord-011917-6u0t4hy8	243	17	the	the	DT
cord-011917-6u0t4hy8	243	18	negative	negative	JJ
cord-011917-6u0t4hy8	243	19	naïve	naïve	JJ
cord-011917-6u0t4hy8	243	20	control	control	NN
cord-011917-6u0t4hy8	243	21	ferret	ferret	NN
cord-011917-6u0t4hy8	243	22	group	group	NN
cord-011917-6u0t4hy8	243	23	providing	provide	VBG
cord-011917-6u0t4hy8	243	24	only	only	JJ
cord-011917-6u0t4hy8	243	25	temporary	temporary	JJ
cord-011917-6u0t4hy8	243	26	protection	protection	NN
cord-011917-6u0t4hy8	243	27	.	.	.
cord-011917-6u0t4hy8	244	1	The	the	DT
cord-011917-6u0t4hy8	244	2	age	age	NN
cord-011917-6u0t4hy8	244	3	and	and	CC
cord-011917-6u0t4hy8	244	4	gender	gender	NN
cord-011917-6u0t4hy8	244	5	of	of	IN
cord-011917-6u0t4hy8	244	6	the	the	DT
cord-011917-6u0t4hy8	244	7	animals	animal	NNS
cord-011917-6u0t4hy8	244	8	being	be	VBG
cord-011917-6u0t4hy8	244	9	used	use	VBN
cord-011917-6u0t4hy8	244	10	may	may	MD
cord-011917-6u0t4hy8	244	11	be	be	VB
cord-011917-6u0t4hy8	244	12	a	a	DT
cord-011917-6u0t4hy8	244	13	confounding	confounding	JJ
cord-011917-6u0t4hy8	244	14	factor	factor	NN
cord-011917-6u0t4hy8	244	15	especially	especially	RB
cord-011917-6u0t4hy8	244	16	when	when	WRB
cord-011917-6u0t4hy8	244	17	comparing	compare	VBG
cord-011917-6u0t4hy8	244	18	humoral	humoral	JJ
cord-011917-6u0t4hy8	244	19	responses	response	NNS
cord-011917-6u0t4hy8	244	20	[	[	-LRB-
cord-011917-6u0t4hy8	244	21	99	99	CD
cord-011917-6u0t4hy8	244	22	,	,	,
cord-011917-6u0t4hy8	244	23	100	100	CD
cord-011917-6u0t4hy8	244	24	]	]	-RRB-
cord-011917-6u0t4hy8	244	25	.	.	.
cord-011917-6u0t4hy8	245	1	The	the	DT
cord-011917-6u0t4hy8	245	2	ages	age	NNS
cord-011917-6u0t4hy8	245	3	for	for	IN
cord-011917-6u0t4hy8	245	4	male	male	JJ
cord-011917-6u0t4hy8	245	5	and	and	CC
cord-011917-6u0t4hy8	245	6	female	female	JJ
cord-011917-6u0t4hy8	245	7	ferrets	ferret	NNS
cord-011917-6u0t4hy8	245	8	ranged	range	VBD
cord-011917-6u0t4hy8	245	9	from	from	IN
cord-011917-6u0t4hy8	245	10	two	two	CD
cord-011917-6u0t4hy8	245	11	to	to	TO
cord-011917-6u0t4hy8	245	12	twelve	twelve	CD
cord-011917-6u0t4hy8	245	13	months	month	NNS
cord-011917-6u0t4hy8	245	14	.	.	.
cord-011917-6u0t4hy8	246	1	Ferrets	ferret	NNS
cord-011917-6u0t4hy8	246	2	were	be	VBD
cord-011917-6u0t4hy8	246	3	considered	consider	VBN
cord-011917-6u0t4hy8	246	4	aged	aged	JJ
cord-011917-6u0t4hy8	246	5	when	when	WRB
cord-011917-6u0t4hy8	246	6	they	-PRON-	PRP
cord-011917-6u0t4hy8	246	7	were	be	VBD
cord-011917-6u0t4hy8	246	8	greater	great	JJR
cord-011917-6u0t4hy8	246	9	than	than	IN
cord-011917-6u0t4hy8	246	10	four	four	CD
cord-011917-6u0t4hy8	246	11	years	year	NNS
cord-011917-6u0t4hy8	246	12	of	of	IN
cord-011917-6u0t4hy8	246	13	age	age	NN
cord-011917-6u0t4hy8	246	14	[	[	-LRB-
cord-011917-6u0t4hy8	246	15	36	36	CD
cord-011917-6u0t4hy8	246	16	]	]	-RRB-
cord-011917-6u0t4hy8	246	17	.	.	.
cord-011917-6u0t4hy8	247	1	Reporting	reporting	NN
cord-011917-6u0t4hy8	247	2	results	result	NNS
cord-011917-6u0t4hy8	247	3	by	by	IN
cord-011917-6u0t4hy8	247	4	gender	gender	NN
cord-011917-6u0t4hy8	247	5	may	may	MD
cord-011917-6u0t4hy8	247	6	reveal	reveal	VB
cord-011917-6u0t4hy8	247	7	new	new	JJ
cord-011917-6u0t4hy8	247	8	avenues	avenue	NNS
cord-011917-6u0t4hy8	247	9	for	for	IN
cord-011917-6u0t4hy8	247	10	influenza	influenza	NN
cord-011917-6u0t4hy8	247	11	virus	virus	NN
cord-011917-6u0t4hy8	247	12	research	research	NN
cord-011917-6u0t4hy8	247	13	.	.	.
cord-011917-6u0t4hy8	248	1	The	the	DT
cord-011917-6u0t4hy8	248	2	breeding	breed	VBG
cord-011917-6u0t4hy8	248	3	vendor	vendor	NN
cord-011917-6u0t4hy8	248	4	and	and	CC
cord-011917-6u0t4hy8	248	5	housing	housing	NN
cord-011917-6u0t4hy8	248	6	conditions	condition	NNS
cord-011917-6u0t4hy8	248	7	of	of	IN
cord-011917-6u0t4hy8	248	8	the	the	DT
cord-011917-6u0t4hy8	248	9	animals	animal	NNS
cord-011917-6u0t4hy8	248	10	should	should	MD
cord-011917-6u0t4hy8	248	11	also	also	RB
cord-011917-6u0t4hy8	248	12	be	be	VB
cord-011917-6u0t4hy8	248	13	reported	report	VBN
cord-011917-6u0t4hy8	248	14	.	.	.
cord-011917-6u0t4hy8	249	1	Within	within	IN
cord-011917-6u0t4hy8	249	2	the	the	DT
cord-011917-6u0t4hy8	249	3	mouse	mouse	NN
cord-011917-6u0t4hy8	249	4	model	model	NN
cord-011917-6u0t4hy8	249	5	,	,	,
cord-011917-6u0t4hy8	249	6	the	the	DT
cord-011917-6u0t4hy8	249	7	microbiome	microbiome	NN
cord-011917-6u0t4hy8	249	8	differs	differ	VBZ
cord-011917-6u0t4hy8	249	9	by	by	IN
cord-011917-6u0t4hy8	249	10	vendor	vendor	NN
cord-011917-6u0t4hy8	249	11	in	in	IN
cord-011917-6u0t4hy8	249	12	the	the	DT
cord-011917-6u0t4hy8	249	13	gut	gut	NN
cord-011917-6u0t4hy8	249	14	[	[	-LRB-
cord-011917-6u0t4hy8	249	15	101	101	CD
cord-011917-6u0t4hy8	249	16	,	,	,
cord-011917-6u0t4hy8	249	17	102	102	CD
cord-011917-6u0t4hy8	249	18	]	]	-RRB-
cord-011917-6u0t4hy8	249	19	and	and	CC
cord-011917-6u0t4hy8	249	20	in	in	IN
cord-011917-6u0t4hy8	249	21	the	the	DT
cord-011917-6u0t4hy8	249	22	lungs	lung	NNS
cord-011917-6u0t4hy8	249	23	[	[	-LRB-
cord-011917-6u0t4hy8	249	24	103	103	CD
cord-011917-6u0t4hy8	249	25	]	]	-RRB-
cord-011917-6u0t4hy8	249	26	,	,	,
cord-011917-6u0t4hy8	249	27	contributing	contribute	VBG
cord-011917-6u0t4hy8	249	28	to	to	IN
cord-011917-6u0t4hy8	249	29	different	different	JJ
cord-011917-6u0t4hy8	249	30	responses	response	NNS
cord-011917-6u0t4hy8	249	31	to	to	IN
cord-011917-6u0t4hy8	249	32	vaccination	vaccination	NN
cord-011917-6u0t4hy8	249	33	and	and	CC
cord-011917-6u0t4hy8	249	34	influenza	influenza	NN
cord-011917-6u0t4hy8	249	35	infection	infection	NN
cord-011917-6u0t4hy8	249	36	[	[	-LRB-
cord-011917-6u0t4hy8	249	37	104	104	CD
cord-011917-6u0t4hy8	249	38	]	]	-RRB-
cord-011917-6u0t4hy8	249	39	[	[	-LRB-
cord-011917-6u0t4hy8	249	40	105	105	CD
cord-011917-6u0t4hy8	249	41	]	]	-RRB-
cord-011917-6u0t4hy8	249	42	[	[	-LRB-
cord-011917-6u0t4hy8	249	43	106	106	CD
cord-011917-6u0t4hy8	249	44	]	]	-RRB-
cord-011917-6u0t4hy8	249	45	.	.	.
cord-011917-6u0t4hy8	250	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	250	2	,	,	,
cord-011917-6u0t4hy8	250	3	it	-PRON-	PRP
cord-011917-6u0t4hy8	250	4	is	be	VBZ
cord-011917-6u0t4hy8	250	5	recommended	recommend	VBN
cord-011917-6u0t4hy8	250	6	that	that	IN
cord-011917-6u0t4hy8	250	7	when	when	WRB
cord-011917-6u0t4hy8	250	8	mice	mouse	NNS
cord-011917-6u0t4hy8	250	9	or	or	CC
cord-011917-6u0t4hy8	250	10	ferrets	ferret	NNS
cord-011917-6u0t4hy8	250	11	are	be	VBP
cord-011917-6u0t4hy8	250	12	housed	house	VBN
cord-011917-6u0t4hy8	250	13	in	in	IN
cord-011917-6u0t4hy8	250	14	separate	separate	JJ
cord-011917-6u0t4hy8	250	15	holding	hold	VBG
cord-011917-6u0t4hy8	250	16	rooms	room	NNS
cord-011917-6u0t4hy8	250	17	,	,	,
cord-011917-6u0t4hy8	250	18	bedding	bedding	NN
cord-011917-6u0t4hy8	250	19	or	or	CC
cord-011917-6u0t4hy8	250	20	enrichment	enrichment	NN
cord-011917-6u0t4hy8	250	21	equipment	equipment	NN
cord-011917-6u0t4hy8	250	22	is	be	VBZ
cord-011917-6u0t4hy8	250	23	shared	share	VBN
cord-011917-6u0t4hy8	250	24	between	between	IN
cord-011917-6u0t4hy8	250	25	the	the	DT
cord-011917-6u0t4hy8	250	26	cages	cage	NNS
cord-011917-6u0t4hy8	250	27	to	to	TO
cord-011917-6u0t4hy8	250	28	merge	merge	VB
cord-011917-6u0t4hy8	250	29	the	the	DT
cord-011917-6u0t4hy8	250	30	microbiomes	microbiome	NNS
cord-011917-6u0t4hy8	250	31	together	together	RB
cord-011917-6u0t4hy8	250	32	[	[	-LRB-
cord-011917-6u0t4hy8	250	33	105	105	CD
cord-011917-6u0t4hy8	250	34	]	]	-RRB-
cord-011917-6u0t4hy8	250	35	.	.	.
cord-011917-6u0t4hy8	251	1	Inclusion	inclusion	NN
cord-011917-6u0t4hy8	251	2	of	of	IN
cord-011917-6u0t4hy8	251	3	the	the	DT
cord-011917-6u0t4hy8	251	4	ferret	ferret	JJ
cord-011917-6u0t4hy8	251	5	health	health	NN
cord-011917-6u0t4hy8	251	6	history	history	NN
cord-011917-6u0t4hy8	251	7	is	be	VBZ
cord-011917-6u0t4hy8	251	8	also	also	RB
cord-011917-6u0t4hy8	251	9	beneficial	beneficial	JJ
cord-011917-6u0t4hy8	251	10	.	.	.
cord-011917-6u0t4hy8	252	1	Metadata	metadata	VB
cord-011917-6u0t4hy8	252	2	such	such	JJ
cord-011917-6u0t4hy8	252	3	as	as	IN
cord-011917-6u0t4hy8	252	4	whether	whether	IN
cord-011917-6u0t4hy8	252	5	they	-PRON-	PRP
cord-011917-6u0t4hy8	252	6	were	be	VBD
cord-011917-6u0t4hy8	252	7	castrated	castrate	VBN
cord-011917-6u0t4hy8	252	8	,	,	,
cord-011917-6u0t4hy8	252	9	spayed	spay	VBN
cord-011917-6u0t4hy8	252	10	,	,	,
cord-011917-6u0t4hy8	252	11	de	de	JJ
cord-011917-6u0t4hy8	252	12	-	-	JJ
cord-011917-6u0t4hy8	252	13	scented	scented	JJ
cord-011917-6u0t4hy8	252	14	,	,	,
cord-011917-6u0t4hy8	252	15	or	or	CC
cord-011917-6u0t4hy8	252	16	received	receive	VBD
cord-011917-6u0t4hy8	252	17	any	any	DT
cord-011917-6u0t4hy8	252	18	previous	previous	JJ
cord-011917-6u0t4hy8	252	19	vaccinations	vaccination	NNS
cord-011917-6u0t4hy8	252	20	or	or	CC
cord-011917-6u0t4hy8	252	21	treatments	treatment	NNS
cord-011917-6u0t4hy8	252	22	may	may	MD
cord-011917-6u0t4hy8	252	23	shed	shed	VB
cord-011917-6u0t4hy8	252	24	light	light	NN
cord-011917-6u0t4hy8	252	25	on	on	IN
cord-011917-6u0t4hy8	252	26	immunological	immunological	JJ
cord-011917-6u0t4hy8	252	27	results	result	NNS
cord-011917-6u0t4hy8	252	28	.	.	.
cord-011917-6u0t4hy8	253	1	The	the	DT
cord-011917-6u0t4hy8	253	2	ferret	ferret	NN
cord-011917-6u0t4hy8	253	3	model	model	NN
cord-011917-6u0t4hy8	253	4	captures	capture	VBZ
cord-011917-6u0t4hy8	253	5	special	special	JJ
cord-011917-6u0t4hy8	253	6	at	at	IN
cord-011917-6u0t4hy8	253	7	-	-	HYPH
cord-011917-6u0t4hy8	253	8	risk	risk	NN
cord-011917-6u0t4hy8	253	9	populations	population	NNS
cord-011917-6u0t4hy8	253	10	.	.	.
cord-011917-6u0t4hy8	254	1	Ferret	ferret	JJ
cord-011917-6u0t4hy8	254	2	age	age	NN
cord-011917-6u0t4hy8	254	3	was	be	VBD
cord-011917-6u0t4hy8	254	4	varied	varied	JJ
cord-011917-6u0t4hy8	254	5	to	to	TO
cord-011917-6u0t4hy8	254	6	encompass	encompass	VB
cord-011917-6u0t4hy8	254	7	different	different	JJ
cord-011917-6u0t4hy8	254	8	age	age	NN
cord-011917-6u0t4hy8	254	9	groups	group	NNS
cord-011917-6u0t4hy8	254	10	:	:	:
cord-011917-6u0t4hy8	254	11	young	young	JJ
cord-011917-6u0t4hy8	254	12	,	,	,
cord-011917-6u0t4hy8	254	13	adult	adult	NN
cord-011917-6u0t4hy8	254	14	and	and	CC
cord-011917-6u0t4hy8	254	15	old	old	JJ
cord-011917-6u0t4hy8	254	16	.	.	.
cord-011917-6u0t4hy8	255	1	Adult	adult	NN
cord-011917-6u0t4hy8	255	2	and	and	CC
cord-011917-6u0t4hy8	255	3	aged	aged	JJ
cord-011917-6u0t4hy8	255	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	255	5	,	,	,
cord-011917-6u0t4hy8	255	6	similar	similar	JJ
cord-011917-6u0t4hy8	255	7	to	to	IN
cord-011917-6u0t4hy8	255	8	humans	human	NNS
cord-011917-6u0t4hy8	255	9	,	,	,
cord-011917-6u0t4hy8	255	10	exhibit	exhibit	VB
cord-011917-6u0t4hy8	255	11	significant	significant	JJ
cord-011917-6u0t4hy8	255	12	immune	immune	JJ
cord-011917-6u0t4hy8	255	13	response	response	NN
cord-011917-6u0t4hy8	255	14	differences	difference	NNS
cord-011917-6u0t4hy8	255	15	when	when	WRB
cord-011917-6u0t4hy8	255	16	comparing	compare	VBG
cord-011917-6u0t4hy8	255	17	homologous	homologous	JJ
cord-011917-6u0t4hy8	255	18	and	and	CC
cord-011917-6u0t4hy8	255	19	heterologous	heterologous	JJ
cord-011917-6u0t4hy8	255	20	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	255	21	)	)	-RRB-
cord-011917-6u0t4hy8	255	22	priming	priming	NN
cord-011917-6u0t4hy8	255	23	and	and	CC
cord-011917-6u0t4hy8	255	24	challenges	challenge	NNS
cord-011917-6u0t4hy8	255	25	suggesting	suggest	VBG
cord-011917-6u0t4hy8	255	26	immune	immune	JJ
cord-011917-6u0t4hy8	255	27	senescence	senescence	NN
cord-011917-6u0t4hy8	255	28	in	in	IN
cord-011917-6u0t4hy8	255	29	the	the	DT
cord-011917-6u0t4hy8	255	30	aged	age	VBN
cord-011917-6u0t4hy8	255	31	ferret	ferret	JJ
cord-011917-6u0t4hy8	255	32	population	population	NN
cord-011917-6u0t4hy8	255	33	[	[	-LRB-
cord-011917-6u0t4hy8	255	34	36	36	CD
cord-011917-6u0t4hy8	255	35	]	]	-RRB-
cord-011917-6u0t4hy8	255	36	.	.	.
cord-011917-6u0t4hy8	256	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	256	2	,	,	,
cord-011917-6u0t4hy8	256	3	the	the	DT
cord-011917-6u0t4hy8	256	4	use	use	NN
cord-011917-6u0t4hy8	256	5	of	of	IN
cord-011917-6u0t4hy8	256	6	this	this	DT
cord-011917-6u0t4hy8	256	7	model	model	NN
cord-011917-6u0t4hy8	256	8	would	would	MD
cord-011917-6u0t4hy8	256	9	contribute	contribute	VB
cord-011917-6u0t4hy8	256	10	to	to	IN
cord-011917-6u0t4hy8	256	11	vaccine	vaccine	NN
cord-011917-6u0t4hy8	256	12	testing	testing	NN
cord-011917-6u0t4hy8	256	13	and	and	CC
cord-011917-6u0t4hy8	256	14	efficacy	efficacy	NN
cord-011917-6u0t4hy8	256	15	studies	study	NNS
cord-011917-6u0t4hy8	256	16	.	.	.
cord-011917-6u0t4hy8	257	1	Currently	currently	RB
cord-011917-6u0t4hy8	257	2	,	,	,
cord-011917-6u0t4hy8	257	3	a	a	DT
cord-011917-6u0t4hy8	257	4	vaccine	vaccine	NN
cord-011917-6u0t4hy8	257	5	specifically	specifically	RB
cord-011917-6u0t4hy8	257	6	formulated	formulate	VBN
cord-011917-6u0t4hy8	257	7	for	for	IN
cord-011917-6u0t4hy8	257	8	aged	aged	JJ
cord-011917-6u0t4hy8	257	9	individuals	individual	NNS
cord-011917-6u0t4hy8	257	10	already	already	RB
cord-011917-6u0t4hy8	257	11	exists	exist	VBZ
cord-011917-6u0t4hy8	257	12	due	due	JJ
cord-011917-6u0t4hy8	257	13	to	to	IN
cord-011917-6u0t4hy8	257	14	their	-PRON-	PRP$
cord-011917-6u0t4hy8	257	15	high	high	JJ
cord-011917-6u0t4hy8	257	16	-	-	HYPH
cord-011917-6u0t4hy8	257	17	risk	risk	NN
cord-011917-6u0t4hy8	257	18	status	status	NN
cord-011917-6u0t4hy8	257	19	and	and	CC
cord-011917-6u0t4hy8	257	20	substantial	substantial	JJ
cord-011917-6u0t4hy8	257	21	contributions	contribution	NNS
cord-011917-6u0t4hy8	257	22	to	to	IN
cord-011917-6u0t4hy8	257	23	influenza	influenza	NN
cord-011917-6u0t4hy8	257	24	-	-	HYPH
cord-011917-6u0t4hy8	257	25	associated	associate	VBN
cord-011917-6u0t4hy8	257	26	hospitalizations	hospitalization	NNS
cord-011917-6u0t4hy8	257	27	and	and	CC
cord-011917-6u0t4hy8	257	28	deaths	death	NNS
cord-011917-6u0t4hy8	257	29	[	[	-LRB-
cord-011917-6u0t4hy8	257	30	33	33	CD
cord-011917-6u0t4hy8	257	31	,	,	,
cord-011917-6u0t4hy8	257	32	107	107	CD
cord-011917-6u0t4hy8	257	33	,	,	,
cord-011917-6u0t4hy8	257	34	108	108	CD
cord-011917-6u0t4hy8	257	35	]	]	-RRB-
cord-011917-6u0t4hy8	257	36	;	;	:
cord-011917-6u0t4hy8	257	37	this	this	DT
cord-011917-6u0t4hy8	257	38	high	high	JJ
cord-011917-6u0t4hy8	257	39	dose	dose	NN
cord-011917-6u0t4hy8	257	40	vaccine	vaccine	NN
cord-011917-6u0t4hy8	257	41	contains	contain	VBZ
cord-011917-6u0t4hy8	257	42	60	60	CD
cord-011917-6u0t4hy8	257	43	ug	ug	NNS
cord-011917-6u0t4hy8	257	44	of	of	IN
cord-011917-6u0t4hy8	257	45	each	each	DT
cord-011917-6u0t4hy8	257	46	vaccine	vaccine	NN
cord-011917-6u0t4hy8	257	47	strain	strain	NN
cord-011917-6u0t4hy8	257	48	HA	HA	NNP
cord-011917-6u0t4hy8	257	49	,	,	,
cord-011917-6u0t4hy8	257	50	compared	compare	VBN
cord-011917-6u0t4hy8	257	51	to	to	IN
cord-011917-6u0t4hy8	257	52	the	the	DT
cord-011917-6u0t4hy8	257	53	standard	standard	JJ
cord-011917-6u0t4hy8	257	54	15	15	CD
cord-011917-6u0t4hy8	257	55	ug	ug	NNP
cord-011917-6u0t4hy8	257	56	.	.	.
cord-011917-6u0t4hy8	258	1	The	the	DT
cord-011917-6u0t4hy8	258	2	National	National	NNP
cord-011917-6u0t4hy8	258	3	Institute	Institute	NNP
cord-011917-6u0t4hy8	258	4	of	of	IN
cord-011917-6u0t4hy8	258	5	Allergy	Allergy	NNP
cord-011917-6u0t4hy8	258	6	and	and	CC
cord-011917-6u0t4hy8	258	7	Infectious	Infectious	NNP
cord-011917-6u0t4hy8	258	8	Diseases	Diseases	NNPS
cord-011917-6u0t4hy8	258	9	'	'	POS
cord-011917-6u0t4hy8	258	10	(	(	-LRB-
cord-011917-6u0t4hy8	258	11	NIAID	NIAID	NNP
cord-011917-6u0t4hy8	258	12	)	)	-RRB-
cord-011917-6u0t4hy8	258	13	goal	goal	NN
cord-011917-6u0t4hy8	258	14	for	for	IN
cord-011917-6u0t4hy8	258	15	the	the	DT
cord-011917-6u0t4hy8	258	16	development	development	NN
cord-011917-6u0t4hy8	258	17	of	of	IN
cord-011917-6u0t4hy8	258	18	a	a	DT
cord-011917-6u0t4hy8	258	19	universal	universal	JJ
cord-011917-6u0t4hy8	258	20	influenza	influenza	NN
cord-011917-6u0t4hy8	258	21	vaccine	vaccine	NN
cord-011917-6u0t4hy8	258	22	requires	require	VBZ
cord-011917-6u0t4hy8	258	23	a	a	DT
cord-011917-6u0t4hy8	258	24	protection	protection	NN
cord-011917-6u0t4hy8	258	25	equal	equal	JJ
cord-011917-6u0t4hy8	258	26	to	to	IN
cord-011917-6u0t4hy8	258	27	or	or	CC
cord-011917-6u0t4hy8	258	28	greater	great	JJR
cord-011917-6u0t4hy8	258	29	than	than	IN
cord-011917-6u0t4hy8	258	30	75	75	CD
cord-011917-6u0t4hy8	258	31	%	%	NN
cord-011917-6u0t4hy8	258	32	against	against	IN
cord-011917-6u0t4hy8	258	33	symptomatic	symptomatic	JJ
cord-011917-6u0t4hy8	258	34	disease	disease	NN
cord-011917-6u0t4hy8	258	35	lasting	last	VBG
cord-011917-6u0t4hy8	258	36	at	at	RB
cord-011917-6u0t4hy8	258	37	least	least	RBS
cord-011917-6u0t4hy8	258	38	one	one	CD
cord-011917-6u0t4hy8	258	39	year	year	NN
cord-011917-6u0t4hy8	258	40	in	in	IN
cord-011917-6u0t4hy8	258	41	all	all	DT
cord-011917-6u0t4hy8	258	42	populations	population	NNS
cord-011917-6u0t4hy8	258	43	,	,	,
cord-011917-6u0t4hy8	258	44	including	include	VBG
cord-011917-6u0t4hy8	258	45	,	,	,
cord-011917-6u0t4hy8	258	46	at	at	IN
cord-011917-6u0t4hy8	258	47	-	-	HYPH
cord-011917-6u0t4hy8	258	48	risk	risk	NN
cord-011917-6u0t4hy8	258	49	populations	population	NNS
cord-011917-6u0t4hy8	258	50	[	[	-LRB-
cord-011917-6u0t4hy8	258	51	109	109	CD
cord-011917-6u0t4hy8	258	52	]	]	-RRB-
cord-011917-6u0t4hy8	258	53	.	.	.
cord-011917-6u0t4hy8	259	1	The	the	DT
cord-011917-6u0t4hy8	259	2	addition	addition	NN
cord-011917-6u0t4hy8	259	3	of	of	IN
cord-011917-6u0t4hy8	259	4	pre	pre	JJ
cord-011917-6u0t4hy8	259	5	-	-	JJ
cord-011917-6u0t4hy8	259	6	existing	existing	JJ
cord-011917-6u0t4hy8	259	7	immune	immune	JJ
cord-011917-6u0t4hy8	259	8	responses	response	NNS
cord-011917-6u0t4hy8	259	9	to	to	IN
cord-011917-6u0t4hy8	259	10	these	these	DT
cord-011917-6u0t4hy8	259	11	various	various	JJ
cord-011917-6u0t4hy8	259	12	at	at	IN
cord-011917-6u0t4hy8	259	13	-	-	HYPH
cord-011917-6u0t4hy8	259	14	risk	risk	NN
cord-011917-6u0t4hy8	259	15	population	population	NN
cord-011917-6u0t4hy8	259	16	models	model	NNS
cord-011917-6u0t4hy8	259	17	more	more	RBR
cord-011917-6u0t4hy8	259	18	accurately	accurately	RB
cord-011917-6u0t4hy8	259	19	reflects	reflect	VBZ
cord-011917-6u0t4hy8	259	20	the	the	DT
cord-011917-6u0t4hy8	259	21	variation	variation	NN
cord-011917-6u0t4hy8	259	22	of	of	IN
cord-011917-6u0t4hy8	259	23	the	the	DT
cord-011917-6u0t4hy8	259	24	human	human	JJ
cord-011917-6u0t4hy8	259	25	population	population	NN
cord-011917-6u0t4hy8	259	26	and	and	CC
cord-011917-6u0t4hy8	259	27	allows	allow	VBZ
cord-011917-6u0t4hy8	259	28	for	for	IN
cord-011917-6u0t4hy8	259	29	appropriate	appropriate	JJ
cord-011917-6u0t4hy8	259	30	testing	testing	NN
cord-011917-6u0t4hy8	259	31	of	of	IN
cord-011917-6u0t4hy8	259	32	novel	novel	JJ
cord-011917-6u0t4hy8	259	33	vaccine	vaccine	NN
cord-011917-6u0t4hy8	259	34	candidates	candidate	NNS
cord-011917-6u0t4hy8	259	35	.	.	.
cord-011917-6u0t4hy8	260	1	The	the	DT
cord-011917-6u0t4hy8	260	2	effects	effect	NNS
cord-011917-6u0t4hy8	260	3	of	of	IN
cord-011917-6u0t4hy8	260	4	imprinting	imprinting	NN
cord-011917-6u0t4hy8	260	5	and	and	CC
cord-011917-6u0t4hy8	260	6	pre	pre	JJ
cord-011917-6u0t4hy8	260	7	-	-	NN
cord-011917-6u0t4hy8	260	8	immunity	immunity	NN
cord-011917-6u0t4hy8	260	9	on	on	IN
cord-011917-6u0t4hy8	260	10	subsequent	subsequent	JJ
cord-011917-6u0t4hy8	260	11	humoral	humoral	JJ
cord-011917-6u0t4hy8	260	12	and	and	CC
cord-011917-6u0t4hy8	260	13	cellular	cellular	JJ
cord-011917-6u0t4hy8	260	14	responses	response	NNS
cord-011917-6u0t4hy8	260	15	are	be	VBP
cord-011917-6u0t4hy8	260	16	still	still	RB
cord-011917-6u0t4hy8	260	17	under	under	IN
cord-011917-6u0t4hy8	260	18	investigation	investigation	NN
cord-011917-6u0t4hy8	260	19	.	.	.
cord-011917-6u0t4hy8	261	1	During	during	IN
cord-011917-6u0t4hy8	261	2	initial	initial	JJ
cord-011917-6u0t4hy8	261	3	pre	pre	JJ
cord-011917-6u0t4hy8	261	4	-	-	JJ
cord-011917-6u0t4hy8	261	5	immune	immune	JJ
cord-011917-6u0t4hy8	261	6	ferret	ferret	NN
cord-011917-6u0t4hy8	261	7	infection	infection	NN
cord-011917-6u0t4hy8	261	8	,	,	,
cord-011917-6u0t4hy8	261	9	there	there	EX
cord-011917-6u0t4hy8	261	10	are	be	VBP
cord-011917-6u0t4hy8	261	11	increased	increase	VBN
cord-011917-6u0t4hy8	261	12	nasal	nasal	NN
cord-011917-6u0t4hy8	261	13	protein	protein	NN
cord-011917-6u0t4hy8	261	14	secretions	secretion	NNS
cord-011917-6u0t4hy8	261	15	compared	compare	VBN
cord-011917-6u0t4hy8	261	16	to	to	IN
cord-011917-6u0t4hy8	261	17	naïve	naïve	JJ
cord-011917-6u0t4hy8	261	18	ferrets	ferret	NNS
cord-011917-6u0t4hy8	261	19	during	during	IN
cord-011917-6u0t4hy8	261	20	a	a	DT
cord-011917-6u0t4hy8	261	21	heterologous	heterologous	JJ
cord-011917-6u0t4hy8	261	22	challenge	challenge	NN
cord-011917-6u0t4hy8	261	23	[	[	-LRB-
cord-011917-6u0t4hy8	261	24	39	39	CD
cord-011917-6u0t4hy8	261	25	]	]	-RRB-
cord-011917-6u0t4hy8	261	26	.	.	.
cord-011917-6u0t4hy8	262	1	Characterization	characterization	NN
cord-011917-6u0t4hy8	262	2	of	of	IN
cord-011917-6u0t4hy8	262	3	the	the	DT
cord-011917-6u0t4hy8	262	4	influenza	influenza	NN
cord-011917-6u0t4hy8	262	5	virus	virus	NN
cord-011917-6u0t4hy8	262	6	infectome	infectome	NNP
cord-011917-6u0t4hy8	262	7	during	during	IN
cord-011917-6u0t4hy8	262	8	different	different	JJ
cord-011917-6u0t4hy8	262	9	stages	stage	NNS
cord-011917-6u0t4hy8	262	10	of	of	IN
cord-011917-6u0t4hy8	262	11	the	the	DT
cord-011917-6u0t4hy8	262	12	infectious	infectious	JJ
cord-011917-6u0t4hy8	262	13	process	process	NN
cord-011917-6u0t4hy8	262	14	,	,	,
cord-011917-6u0t4hy8	262	15	with	with	IN
cord-011917-6u0t4hy8	262	16	and	and	CC
cord-011917-6u0t4hy8	262	17	without	without	IN
cord-011917-6u0t4hy8	262	18	prior	prior	JJ
cord-011917-6u0t4hy8	262	19	specific	specific	JJ
cord-011917-6u0t4hy8	262	20	immunity	immunity	NN
cord-011917-6u0t4hy8	262	21	to	to	IN
cord-011917-6u0t4hy8	262	22	influenza	influenza	NN
cord-011917-6u0t4hy8	262	23	,	,	,
cord-011917-6u0t4hy8	262	24	has	have	VBZ
cord-011917-6u0t4hy8	262	25	recently	recently	RB
cord-011917-6u0t4hy8	262	26	been	be	VBN
cord-011917-6u0t4hy8	262	27	reported	report	VBN
cord-011917-6u0t4hy8	262	28	[	[	-LRB-
cord-011917-6u0t4hy8	262	29	87	87	CD
cord-011917-6u0t4hy8	262	30	]	]	-RRB-
cord-011917-6u0t4hy8	262	31	.	.	.
cord-011917-6u0t4hy8	263	1	The	the	DT
cord-011917-6u0t4hy8	263	2	differences	difference	NNS
cord-011917-6u0t4hy8	263	3	in	in	IN
cord-011917-6u0t4hy8	263	4	protection	protection	NN
cord-011917-6u0t4hy8	263	5	of	of	IN
cord-011917-6u0t4hy8	263	6	a	a	DT
cord-011917-6u0t4hy8	263	7	pre	pre	JJ
cord-011917-6u0t4hy8	263	8	-	-	JJ
cord-011917-6u0t4hy8	263	9	immune	immune	JJ
cord-011917-6u0t4hy8	263	10	animal	animal	NN
cord-011917-6u0t4hy8	263	11	compared	compare	VBN
cord-011917-6u0t4hy8	263	12	to	to	IN
cord-011917-6u0t4hy8	263	13	a	a	DT
cord-011917-6u0t4hy8	263	14	naïve	naïve	JJ
cord-011917-6u0t4hy8	263	15	animal	animal	NN
cord-011917-6u0t4hy8	263	16	may	may	MD
cord-011917-6u0t4hy8	263	17	be	be	VB
cord-011917-6u0t4hy8	263	18	due	due	JJ
cord-011917-6u0t4hy8	263	19	to	to	TO
cord-011917-6u0t4hy8	263	20	recall	recall	NN
cord-011917-6u0t4hy8	263	21	of	of	IN
cord-011917-6u0t4hy8	263	22	antibodies	antibody	NNS
cord-011917-6u0t4hy8	263	23	specific	specific	JJ
cord-011917-6u0t4hy8	263	24	to	to	IN
cord-011917-6u0t4hy8	263	25	shared	share	VBN
cord-011917-6u0t4hy8	263	26	epitopes	epitope	NNS
cord-011917-6u0t4hy8	263	27	which	which	WDT
cord-011917-6u0t4hy8	263	28	do	do	VBP
cord-011917-6u0t4hy8	263	29	not	not	RB
cord-011917-6u0t4hy8	263	30	necessary	necessary	JJ
cord-011917-6u0t4hy8	263	31	need	need	VB
cord-011917-6u0t4hy8	263	32	to	to	TO
cord-011917-6u0t4hy8	263	33	be	be	VB
cord-011917-6u0t4hy8	263	34	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	263	35	[	[	-LRB-
cord-011917-6u0t4hy8	263	36	110	110	CD
cord-011917-6u0t4hy8	263	37	]	]	-RRB-
cord-011917-6u0t4hy8	263	38	.	.	.
cord-011917-6u0t4hy8	264	1	Infection	infection	NN
cord-011917-6u0t4hy8	264	2	induces	induce	VBZ
cord-011917-6u0t4hy8	264	3	T	t	NN
cord-011917-6u0t4hy8	264	4	-	-	HYPH
cord-011917-6u0t4hy8	264	5	cell	cell	NN
cord-011917-6u0t4hy8	264	6	responses	response	NNS
cord-011917-6u0t4hy8	264	7	to	to	IN
cord-011917-6u0t4hy8	264	8	T	t	NN
cord-011917-6u0t4hy8	264	9	-	-	HYPH
cord-011917-6u0t4hy8	264	10	cell	cell	NN
cord-011917-6u0t4hy8	264	11	epitopes	epitope	NNS
cord-011917-6u0t4hy8	264	12	within	within	IN
cord-011917-6u0t4hy8	264	13	the	the	DT
cord-011917-6u0t4hy8	264	14	HA	HA	NNP
cord-011917-6u0t4hy8	264	15	and	and	CC
cord-011917-6u0t4hy8	264	16	other	other	JJ
cord-011917-6u0t4hy8	264	17	proteins	protein	NNS
cord-011917-6u0t4hy8	264	18	,	,	,
cord-011917-6u0t4hy8	264	19	and	and	CC
cord-011917-6u0t4hy8	264	20	even	even	RB
cord-011917-6u0t4hy8	264	21	neuraminidase	neuraminidase	NN
cord-011917-6u0t4hy8	264	22	inhibiting	inhibit	VBG
cord-011917-6u0t4hy8	264	23	antibodies	antibody	NNS
cord-011917-6u0t4hy8	264	24	that	that	WDT
cord-011917-6u0t4hy8	264	25	are	be	VBP
cord-011917-6u0t4hy8	264	26	not	not	RB
cord-011917-6u0t4hy8	264	27	elicited	elicit	VBN
cord-011917-6u0t4hy8	264	28	by	by	IN
cord-011917-6u0t4hy8	264	29	split	split	NN
cord-011917-6u0t4hy8	264	30	-	-	HYPH
cord-011917-6u0t4hy8	264	31	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	264	32	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	264	33	[	[	-LRB-
cord-011917-6u0t4hy8	264	34	41	41	CD
cord-011917-6u0t4hy8	264	35	,	,	,
cord-011917-6u0t4hy8	264	36	111	111	CD
cord-011917-6u0t4hy8	264	37	]	]	-RRB-
cord-011917-6u0t4hy8	264	38	.	.	.
cord-011917-6u0t4hy8	265	1	These	these	DT
cord-011917-6u0t4hy8	265	2	responses	response	NNS
cord-011917-6u0t4hy8	265	3	may	may	MD
cord-011917-6u0t4hy8	265	4	be	be	VB
cord-011917-6u0t4hy8	265	5	either	either	CC
cord-011917-6u0t4hy8	265	6	synergistic	synergistic	JJ
cord-011917-6u0t4hy8	265	7	or	or	CC
cord-011917-6u0t4hy8	265	8	antagonistic	antagonistic	JJ
cord-011917-6u0t4hy8	265	9	when	when	WRB
cord-011917-6u0t4hy8	265	10	paired	pair	VBN
cord-011917-6u0t4hy8	265	11	with	with	IN
cord-011917-6u0t4hy8	265	12	vaccination	vaccination	NN
cord-011917-6u0t4hy8	265	13	.	.	.
cord-011917-6u0t4hy8	266	1	For	for	IN
cord-011917-6u0t4hy8	266	2	instance	instance	NN
cord-011917-6u0t4hy8	266	3	,	,	,
cord-011917-6u0t4hy8	266	4	vaccination	vaccination	NN
cord-011917-6u0t4hy8	266	5	may	may	MD
cord-011917-6u0t4hy8	266	6	boost	boost	VB
cord-011917-6u0t4hy8	266	7	the	the	DT
cord-011917-6u0t4hy8	266	8	non	non	JJ
cord-011917-6u0t4hy8	266	9	-	-	JJ
cord-011917-6u0t4hy8	266	10	neutralizing	neutralizing	JJ
cord-011917-6u0t4hy8	266	11	antibodies	antibody	NNS
cord-011917-6u0t4hy8	266	12	leading	lead	VBG
cord-011917-6u0t4hy8	266	13	to	to	IN
cord-011917-6u0t4hy8	266	14	decreased	decrease	VBN
cord-011917-6u0t4hy8	266	15	vaccine	vaccine	NN
cord-011917-6u0t4hy8	266	16	efficacy	efficacy	NN
cord-011917-6u0t4hy8	266	17	compared	compare	VBN
cord-011917-6u0t4hy8	266	18	to	to	IN
cord-011917-6u0t4hy8	266	19	a	a	DT
cord-011917-6u0t4hy8	266	20	naïve	naïve	JJ
cord-011917-6u0t4hy8	266	21	animal	animal	NN
cord-011917-6u0t4hy8	266	22	.	.	.
cord-011917-6u0t4hy8	267	1	This	this	DT
cord-011917-6u0t4hy8	267	2	back	back	NN
cord-011917-6u0t4hy8	267	3	-	-	HYPH
cord-011917-6u0t4hy8	267	4	boosting	boosting	NN
cord-011917-6u0t4hy8	267	5	,	,	,
cord-011917-6u0t4hy8	267	6	also	also	RB
cord-011917-6u0t4hy8	267	7	described	describe	VBN
cord-011917-6u0t4hy8	267	8	as	as	IN
cord-011917-6u0t4hy8	267	9	an	an	DT
cord-011917-6u0t4hy8	267	10	anamnestic	anamnestic	JJ
cord-011917-6u0t4hy8	267	11	response	response	NN
cord-011917-6u0t4hy8	267	12	,	,	,
cord-011917-6u0t4hy8	267	13	has	have	VBZ
cord-011917-6u0t4hy8	267	14	been	be	VBN
cord-011917-6u0t4hy8	267	15	observed	observe	VBN
cord-011917-6u0t4hy8	267	16	in	in	IN
cord-011917-6u0t4hy8	267	17	the	the	DT
cord-011917-6u0t4hy8	267	18	human	human	JJ
cord-011917-6u0t4hy8	267	19	population	population	NN
cord-011917-6u0t4hy8	267	20	[	[	-LRB-
cord-011917-6u0t4hy8	267	21	112	112	CD
cord-011917-6u0t4hy8	267	22	]	]	-RRB-
cord-011917-6u0t4hy8	267	23	[	[	-LRB-
cord-011917-6u0t4hy8	267	24	113	113	CD
cord-011917-6u0t4hy8	267	25	]	]	-RRB-
cord-011917-6u0t4hy8	267	26	[	[	-LRB-
cord-011917-6u0t4hy8	267	27	114	114	CD
cord-011917-6u0t4hy8	267	28	]	]	-RRB-
cord-011917-6u0t4hy8	267	29	[	[	-LRB-
cord-011917-6u0t4hy8	267	30	115	115	CD
cord-011917-6u0t4hy8	267	31	]	]	-RRB-
cord-011917-6u0t4hy8	267	32	and	and	CC
cord-011917-6u0t4hy8	267	33	has	have	VBZ
cord-011917-6u0t4hy8	267	34	been	be	VBN
cord-011917-6u0t4hy8	267	35	recapitulated	recapitulate	VBN
cord-011917-6u0t4hy8	267	36	within	within	IN
cord-011917-6u0t4hy8	267	37	the	the	DT
cord-011917-6u0t4hy8	267	38	ferret	ferret	JJ
cord-011917-6u0t4hy8	267	39	model	model	NN
cord-011917-6u0t4hy8	267	40	.	.	.
cord-011917-6u0t4hy8	268	1	This	this	DT
cord-011917-6u0t4hy8	268	2	similarity	similarity	NN
cord-011917-6u0t4hy8	268	3	makes	make	VBZ
cord-011917-6u0t4hy8	268	4	it	-PRON-	PRP
cord-011917-6u0t4hy8	268	5	a	a	DT
cord-011917-6u0t4hy8	268	6	useful	useful	JJ
cord-011917-6u0t4hy8	268	7	tool	tool	NN
cord-011917-6u0t4hy8	268	8	for	for	IN
cord-011917-6u0t4hy8	268	9	determining	determine	VBG
cord-011917-6u0t4hy8	268	10	vaccine	vaccine	NN
cord-011917-6u0t4hy8	268	11	performance	performance	NN
cord-011917-6u0t4hy8	268	12	in	in	IN
cord-011917-6u0t4hy8	268	13	a	a	DT
cord-011917-6u0t4hy8	268	14	setting	setting	NN
cord-011917-6u0t4hy8	268	15	where	where	WRB
cord-011917-6u0t4hy8	268	16	back	back	RB
cord-011917-6u0t4hy8	268	17	-	-	HYPH
cord-011917-6u0t4hy8	268	18	boosting	boosting	NN
cord-011917-6u0t4hy8	268	19	is	be	VBZ
cord-011917-6u0t4hy8	268	20	present	present	JJ
cord-011917-6u0t4hy8	268	21	[	[	-LRB-
cord-011917-6u0t4hy8	268	22	37	37	CD
cord-011917-6u0t4hy8	268	23	]	]	-RRB-
cord-011917-6u0t4hy8	268	24	.	.	.
cord-011917-6u0t4hy8	269	1	Specifically	specifically	RB
cord-011917-6u0t4hy8	269	2	,	,	,
cord-011917-6u0t4hy8	269	3	back	back	RB
cord-011917-6u0t4hy8	269	4	-	-	HYPH
cord-011917-6u0t4hy8	269	5	boosting	boosting	NN
cord-011917-6u0t4hy8	269	6	was	be	VBD
cord-011917-6u0t4hy8	269	7	observed	observe	VBN
cord-011917-6u0t4hy8	269	8	when	when	WRB
cord-011917-6u0t4hy8	269	9	imprinted	imprint	VBN
cord-011917-6u0t4hy8	269	10	with	with	IN
cord-011917-6u0t4hy8	269	11	A(H1N1)/Singapore/6/1986	A(H1N1)/Singapore/6/1986	NNP
cord-011917-6u0t4hy8	269	12	followed	follow	VBN
cord-011917-6u0t4hy8	269	13	by	by	IN
cord-011917-6u0t4hy8	269	14	A(H1N1)/California/07/2009	A(H1N1)/California/07/2009	NNP
cord-011917-6u0t4hy8	269	15	VLP	VLP	NNP
cord-011917-6u0t4hy8	269	16	vaccination	vaccination	NN
cord-011917-6u0t4hy8	269	17	.	.	.
cord-011917-6u0t4hy8	270	1	The	the	DT
cord-011917-6u0t4hy8	270	2	breadth	breadth	NN
cord-011917-6u0t4hy8	270	3	of	of	IN
cord-011917-6u0t4hy8	270	4	HAI	HAI	NNP
cord-011917-6u0t4hy8	270	5	-	-	HYPH
cord-011917-6u0t4hy8	270	6	specific	specific	JJ
cord-011917-6u0t4hy8	270	7	antibody	antibody	NN
cord-011917-6u0t4hy8	270	8	response	response	NN
cord-011917-6u0t4hy8	270	9	was	be	VBD
cord-011917-6u0t4hy8	270	10	wider	wide	JJR
cord-011917-6u0t4hy8	270	11	than	than	IN
cord-011917-6u0t4hy8	270	12	just	just	RB
cord-011917-6u0t4hy8	270	13	A(H1N1)/Singapore/6/1986	A(H1N1)/Singapore/6/1986	NNP
cord-011917-6u0t4hy8	270	14	alone	alone	JJ
cord-011917-6u0t4hy8	270	15	and	and	CC
cord-011917-6u0t4hy8	270	16	covered	cover	VBD
cord-011917-6u0t4hy8	270	17	more	more	JJR
cord-011917-6u0t4hy8	270	18	viruses	virus	NNS
cord-011917-6u0t4hy8	270	19	.	.	.
cord-011917-6u0t4hy8	271	1	The	the	DT
cord-011917-6u0t4hy8	271	2	breadth	breadth	NN
cord-011917-6u0t4hy8	271	3	increased	increase	VBD
cord-011917-6u0t4hy8	271	4	to	to	TO
cord-011917-6u0t4hy8	271	5	include	include	VB
cord-011917-6u0t4hy8	271	6	viruses	virus	NNS
cord-011917-6u0t4hy8	271	7	before	before	IN
cord-011917-6u0t4hy8	271	8	and	and	CC
cord-011917-6u0t4hy8	271	9	after	after	IN
cord-011917-6u0t4hy8	271	10	the	the	DT
cord-011917-6u0t4hy8	271	11	1986	1986	CD
cord-011917-6u0t4hy8	271	12	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	271	13	virus	virus	NN
cord-011917-6u0t4hy8	271	14	[	[	-LRB-
cord-011917-6u0t4hy8	271	15	59	59	CD
cord-011917-6u0t4hy8	271	16	]	]	-RRB-
cord-011917-6u0t4hy8	271	17	.	.	.
cord-011917-6u0t4hy8	272	1	The	the	DT
cord-011917-6u0t4hy8	272	2	back	back	NN
cord-011917-6u0t4hy8	272	3	-	-	HYPH
cord-011917-6u0t4hy8	272	4	boosting	boosting	NN
cord-011917-6u0t4hy8	272	5	observed	observe	VBN
cord-011917-6u0t4hy8	272	6	after	after	IN
cord-011917-6u0t4hy8	272	7	a	a	DT
cord-011917-6u0t4hy8	272	8	VLP	VLP	NNP
cord-011917-6u0t4hy8	272	9	-	-	HYPH
cord-011917-6u0t4hy8	272	10	vaccination	vaccination	NN
cord-011917-6u0t4hy8	272	11	was	be	VBD
cord-011917-6u0t4hy8	272	12	dependent	dependent	JJ
cord-011917-6u0t4hy8	272	13	on	on	IN
cord-011917-6u0t4hy8	272	14	the	the	DT
cord-011917-6u0t4hy8	272	15	recognition	recognition	NN
cord-011917-6u0t4hy8	272	16	of	of	IN
cord-011917-6u0t4hy8	272	17	memory	memory	NN
cord-011917-6u0t4hy8	272	18	B	b	NN
cord-011917-6u0t4hy8	272	19	-	-	HYPH
cord-011917-6u0t4hy8	272	20	cell	cell	NN
cord-011917-6u0t4hy8	272	21	and	and	CC
cord-011917-6u0t4hy8	272	22	T	t	NN
cord-011917-6u0t4hy8	272	23	-	-	HYPH
cord-011917-6u0t4hy8	272	24	helper	helper	NN
cord-011917-6u0t4hy8	272	25	cell	cell	NN
cord-011917-6u0t4hy8	272	26	epitopes	epitope	NNS
cord-011917-6u0t4hy8	272	27	specific	specific	JJ
cord-011917-6u0t4hy8	272	28	to	to	IN
cord-011917-6u0t4hy8	272	29	the	the	DT
cord-011917-6u0t4hy8	272	30	HA	HA	NNP
cord-011917-6u0t4hy8	272	31	of	of	IN
cord-011917-6u0t4hy8	272	32	the	the	DT
cord-011917-6u0t4hy8	272	33	virus	virus	NN
cord-011917-6u0t4hy8	272	34	.	.	.
cord-011917-6u0t4hy8	273	1	This	this	DT
cord-011917-6u0t4hy8	273	2	increase	increase	NN
cord-011917-6u0t4hy8	273	3	in	in	IN
cord-011917-6u0t4hy8	273	4	breadth	breadth	NN
cord-011917-6u0t4hy8	273	5	was	be	VBD
cord-011917-6u0t4hy8	273	6	also	also	RB
cord-011917-6u0t4hy8	273	7	observed	observe	VBN
cord-011917-6u0t4hy8	273	8	after	after	IN
cord-011917-6u0t4hy8	273	9	sequential	sequential	JJ
cord-011917-6u0t4hy8	273	10	infections	infection	NNS
cord-011917-6u0t4hy8	273	11	with	with	IN
cord-011917-6u0t4hy8	273	12	ELISA	ELISA	NNP
cord-011917-6u0t4hy8	273	13	titers	titer	NNS
cord-011917-6u0t4hy8	273	14	to	to	TO
cord-011917-6u0t4hy8	273	15	total	total	JJ
cord-011917-6u0t4hy8	273	16	antibody	antibody	NN
cord-011917-6u0t4hy8	273	17	binding	bind	VBG
cord-011917-6u0t4hy8	273	18	[	[	-LRB-
cord-011917-6u0t4hy8	273	19	78	78	CD
cord-011917-6u0t4hy8	273	20	]	]	-RRB-
cord-011917-6u0t4hy8	273	21	.	.	.
cord-011917-6u0t4hy8	274	1	This	this	DT
cord-011917-6u0t4hy8	274	2	back	back	NN
cord-011917-6u0t4hy8	274	3	-	-	HYPH
cord-011917-6u0t4hy8	274	4	boosting	boosting	NN
cord-011917-6u0t4hy8	274	5	is	be	VBZ
cord-011917-6u0t4hy8	274	6	what	what	WP
cord-011917-6u0t4hy8	274	7	contributed	contribute	VBD
cord-011917-6u0t4hy8	274	8	to	to	IN
cord-011917-6u0t4hy8	274	9	the	the	DT
cord-011917-6u0t4hy8	274	10	difference	difference	NN
cord-011917-6u0t4hy8	274	11	in	in	IN
cord-011917-6u0t4hy8	274	12	the	the	DT
cord-011917-6u0t4hy8	274	13	naïve	naïve	JJ
cord-011917-6u0t4hy8	274	14	vs.	vs.	FW
cord-011917-6u0t4hy8	274	15	pre	pre	JJ
cord-011917-6u0t4hy8	274	16	-	-	JJ
cord-011917-6u0t4hy8	274	17	immune	immune	JJ
cord-011917-6u0t4hy8	274	18	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	274	19	maps	map	NNS
cord-011917-6u0t4hy8	274	20	of	of	IN
cord-011917-6u0t4hy8	274	21	different	different	JJ
cord-011917-6u0t4hy8	274	22	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	274	23	)	)	-RRB-
cord-011917-6u0t4hy8	275	1	viruses	virus	NNS
cord-011917-6u0t4hy8	275	2	[	[	-LRB-
cord-011917-6u0t4hy8	275	3	79	79	CD
cord-011917-6u0t4hy8	275	4	]	]	-RRB-
cord-011917-6u0t4hy8	275	5	.	.	.
cord-011917-6u0t4hy8	276	1	The	the	DT
cord-011917-6u0t4hy8	276	2	exact	exact	JJ
cord-011917-6u0t4hy8	276	3	mechanism	mechanism	NN
cord-011917-6u0t4hy8	276	4	of	of	IN
cord-011917-6u0t4hy8	276	5	back	back	NN
cord-011917-6u0t4hy8	276	6	-	-	HYPH
cord-011917-6u0t4hy8	276	7	boosting	boosting	NN
cord-011917-6u0t4hy8	276	8	is	be	VBZ
cord-011917-6u0t4hy8	276	9	not	not	RB
cord-011917-6u0t4hy8	276	10	completely	completely	RB
cord-011917-6u0t4hy8	276	11	elucidated	elucidate	VBN
cord-011917-6u0t4hy8	276	12	[	[	-LRB-
cord-011917-6u0t4hy8	276	13	113	113	CD
cord-011917-6u0t4hy8	276	14	]	]	-RRB-
cord-011917-6u0t4hy8	276	15	.	.	.
cord-011917-6u0t4hy8	277	1	Heterosubtypic	heterosubtypic	JJ
cord-011917-6u0t4hy8	277	2	protection	protection	NN
cord-011917-6u0t4hy8	277	3	between	between	IN
cord-011917-6u0t4hy8	277	4	the	the	DT
cord-011917-6u0t4hy8	277	5	Type	type	NN
cord-011917-6u0t4hy8	277	6	A	A	NNP
cord-011917-6u0t4hy8	277	7	influenza	influenza	NN
cord-011917-6u0t4hy8	277	8	strains	strain	NNS
cord-011917-6u0t4hy8	277	9	suggest	suggest	VBP
cord-011917-6u0t4hy8	277	10	that	that	IN
cord-011917-6u0t4hy8	277	11	cross	cross	JJ
cord-011917-6u0t4hy8	277	12	-	-	JJ
cord-011917-6u0t4hy8	277	13	reactive	reactive	JJ
cord-011917-6u0t4hy8	277	14	cellular	cellular	JJ
cord-011917-6u0t4hy8	277	15	immune	immune	JJ
cord-011917-6u0t4hy8	277	16	responses	response	NNS
cord-011917-6u0t4hy8	277	17	may	may	MD
cord-011917-6u0t4hy8	277	18	be	be	VB
cord-011917-6u0t4hy8	277	19	contributing	contribute	VBG
cord-011917-6u0t4hy8	277	20	to	to	IN
cord-011917-6u0t4hy8	277	21	virus	virus	NN
cord-011917-6u0t4hy8	277	22	control	control	VB
cord-011917-6u0t4hy8	277	23	[	[	-LRB-
cord-011917-6u0t4hy8	277	24	83	83	CD
cord-011917-6u0t4hy8	277	25	]	]	-RRB-
cord-011917-6u0t4hy8	277	26	.	.	.
cord-011917-6u0t4hy8	278	1	Protective	protective	JJ
cord-011917-6u0t4hy8	278	2	T	t	NN
cord-011917-6u0t4hy8	278	3	-	-	HYPH
cord-011917-6u0t4hy8	278	4	cell	cell	NN
cord-011917-6u0t4hy8	278	5	responses	response	NNS
cord-011917-6u0t4hy8	278	6	are	be	VBP
cord-011917-6u0t4hy8	278	7	elicited	elicit	VBN
cord-011917-6u0t4hy8	278	8	through	through	IN
cord-011917-6u0t4hy8	278	9	recognition	recognition	NN
cord-011917-6u0t4hy8	278	10	of	of	IN
cord-011917-6u0t4hy8	278	11	cross	cross	JJ
cord-011917-6u0t4hy8	278	12	-	-	JJ
cord-011917-6u0t4hy8	278	13	reactive	reactive	JJ
cord-011917-6u0t4hy8	278	14	epitopes	epitope	NNS
cord-011917-6u0t4hy8	278	15	[	[	-LRB-
cord-011917-6u0t4hy8	278	16	84	84	CD
cord-011917-6u0t4hy8	278	17	,	,	,
cord-011917-6u0t4hy8	278	18	88	88	CD
cord-011917-6u0t4hy8	278	19	]	]	-RRB-
cord-011917-6u0t4hy8	278	20	.	.	.
cord-011917-6u0t4hy8	279	1	Cross	cross	JJ
cord-011917-6u0t4hy8	279	2	-	-	JJ
cord-011917-6u0t4hy8	279	3	reactive	reactive	JJ
cord-011917-6u0t4hy8	279	4	memory	memory	NN
cord-011917-6u0t4hy8	279	5	B	b	NN
cord-011917-6u0t4hy8	279	6	-	-	HYPH
cord-011917-6u0t4hy8	279	7	cells	cell	NNS
cord-011917-6u0t4hy8	279	8	can	can	MD
cord-011917-6u0t4hy8	279	9	also	also	RB
cord-011917-6u0t4hy8	279	10	be	be	VB
cord-011917-6u0t4hy8	279	11	elicited	elicit	VBN
cord-011917-6u0t4hy8	279	12	post	post	JJ
cord-011917-6u0t4hy8	279	13	-	-	JJ
cord-011917-6u0t4hy8	279	14	imprinting	imprinting	JJ
cord-011917-6u0t4hy8	279	15	[	[	-LRB-
cord-011917-6u0t4hy8	279	16	63	63	CD
cord-011917-6u0t4hy8	279	17	]	]	-RRB-
cord-011917-6u0t4hy8	279	18	.	.	.
cord-011917-6u0t4hy8	280	1	Characterization	characterization	NN
cord-011917-6u0t4hy8	280	2	of	of	IN
cord-011917-6u0t4hy8	280	3	the	the	DT
cord-011917-6u0t4hy8	280	4	cellular	cellular	JJ
cord-011917-6u0t4hy8	280	5	and	and	CC
cord-011917-6u0t4hy8	280	6	humoral	humoral	JJ
cord-011917-6u0t4hy8	280	7	responses	response	NNS
cord-011917-6u0t4hy8	280	8	,	,	,
cord-011917-6u0t4hy8	280	9	similar	similar	JJ
cord-011917-6u0t4hy8	280	10	to	to	IN
cord-011917-6u0t4hy8	280	11	the	the	DT
cord-011917-6u0t4hy8	280	12	human	human	NN
cord-011917-6u0t4hy8	280	13	-	-	HYPH
cord-011917-6u0t4hy8	280	14	based	base	VBN
cord-011917-6u0t4hy8	280	15	study	study	NN
cord-011917-6u0t4hy8	280	16	conducted	conduct	VBN
cord-011917-6u0t4hy8	280	17	by	by	IN
cord-011917-6u0t4hy8	280	18	Ryan	Ryan	NNP
cord-011917-6u0t4hy8	280	19	et	et	NNP
cord-011917-6u0t4hy8	280	20	al	al	NNP
cord-011917-6u0t4hy8	280	21	.	.	.
cord-011917-6u0t4hy8	281	1	[	[	-LRB-
cord-011917-6u0t4hy8	281	2	116	116	CD
cord-011917-6u0t4hy8	281	3	]	]	-RRB-
cord-011917-6u0t4hy8	281	4	,	,	,
cord-011917-6u0t4hy8	281	5	with	with	IN
cord-011917-6u0t4hy8	281	6	imprinted	imprint	VBN
cord-011917-6u0t4hy8	281	7	and	and	CC
cord-011917-6u0t4hy8	281	8	sequentially	sequentially	RB
cord-011917-6u0t4hy8	281	9	infected	infect	VBN
cord-011917-6u0t4hy8	281	10	ferrets	ferret	NNS
cord-011917-6u0t4hy8	281	11	is	be	VBZ
cord-011917-6u0t4hy8	281	12	a	a	DT
cord-011917-6u0t4hy8	281	13	priority	priority	NN
cord-011917-6u0t4hy8	281	14	to	to	TO
cord-011917-6u0t4hy8	281	15	determine	determine	VB
cord-011917-6u0t4hy8	281	16	if	if	IN
cord-011917-6u0t4hy8	281	17	cellular	cellular	JJ
cord-011917-6u0t4hy8	281	18	immune	immune	JJ
cord-011917-6u0t4hy8	281	19	responses	response	NNS
cord-011917-6u0t4hy8	281	20	differ	differ	VBP
cord-011917-6u0t4hy8	281	21	with	with	IN
cord-011917-6u0t4hy8	281	22	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	281	23	)	)	-RRB-
cord-011917-6u0t4hy8	281	24	and	and	CC
cord-011917-6u0t4hy8	281	25	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	281	26	)	)	-RRB-
cord-011917-6u0t4hy8	281	27	subtype	subtype	NN
cord-011917-6u0t4hy8	281	28	infections	infection	NNS
cord-011917-6u0t4hy8	281	29	[	[	-LRB-
cord-011917-6u0t4hy8	281	30	116	116	CD
cord-011917-6u0t4hy8	281	31	]	]	-RRB-
cord-011917-6u0t4hy8	281	32	,	,	,
cord-011917-6u0t4hy8	281	33	or	or	CC
cord-011917-6u0t4hy8	281	34	during	during	IN
cord-011917-6u0t4hy8	281	35	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	281	36	)	)	-RRB-
cord-011917-6u0t4hy8	281	37	and	and	CC
cord-011917-6u0t4hy8	281	38	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	281	39	)	)	-RRB-
cord-011917-6u0t4hy8	281	40	influenza	influenza	NN
cord-011917-6u0t4hy8	281	41	virus	virus	NN
cord-011917-6u0t4hy8	281	42	co	co	NNS
cord-011917-6u0t4hy8	281	43	-	-	NNS
cord-011917-6u0t4hy8	281	44	infections	infection	NNS
cord-011917-6u0t4hy8	281	45	[	[	-LRB-
cord-011917-6u0t4hy8	281	46	117	117	CD
cord-011917-6u0t4hy8	281	47	]	]	-RRB-
cord-011917-6u0t4hy8	281	48	,	,	,
cord-011917-6u0t4hy8	281	49	or	or	CC
cord-011917-6u0t4hy8	281	50	with	with	IN
cord-011917-6u0t4hy8	281	51	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	281	52	vs.	vs.	FW
cord-011917-6u0t4hy8	281	53	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	281	54	A(H1N1	a(h1n1	CD
cord-011917-6u0t4hy8	281	55	)	)	-RRB-
cord-011917-6u0t4hy8	282	1	influenza	influenza	NN
cord-011917-6u0t4hy8	282	2	virus	virus	NN
cord-011917-6u0t4hy8	282	3	infections	infection	NNS
cord-011917-6u0t4hy8	282	4	[	[	-LRB-
cord-011917-6u0t4hy8	282	5	118	118	CD
cord-011917-6u0t4hy8	282	6	,	,	,
cord-011917-6u0t4hy8	282	7	119	119	CD
cord-011917-6u0t4hy8	282	8	]	]	-RRB-
cord-011917-6u0t4hy8	282	9	.	.	.
cord-011917-6u0t4hy8	283	1	As	as	IN
cord-011917-6u0t4hy8	283	2	the	the	DT
cord-011917-6u0t4hy8	283	3	reagents	reagent	NNS
cord-011917-6u0t4hy8	283	4	for	for	IN
cord-011917-6u0t4hy8	283	5	the	the	DT
cord-011917-6u0t4hy8	283	6	ferret	ferret	NNP
cord-011917-6u0t4hy8	283	7	animal	animal	NN
cord-011917-6u0t4hy8	283	8	model	model	NN
cord-011917-6u0t4hy8	283	9	continues	continue	VBZ
cord-011917-6u0t4hy8	283	10	to	to	TO
cord-011917-6u0t4hy8	283	11	expand	expand	VB
cord-011917-6u0t4hy8	283	12	,	,	,
cord-011917-6u0t4hy8	283	13	the	the	DT
cord-011917-6u0t4hy8	283	14	opportunities	opportunity	NNS
cord-011917-6u0t4hy8	283	15	to	to	TO
cord-011917-6u0t4hy8	283	16	investigate	investigate	VB
cord-011917-6u0t4hy8	283	17	different	different	JJ
cord-011917-6u0t4hy8	283	18	correlates	correlate	NNS
cord-011917-6u0t4hy8	283	19	of	of	IN
cord-011917-6u0t4hy8	283	20	infection	infection	NN
cord-011917-6u0t4hy8	284	1	and/or	and/or	CC
cord-011917-6u0t4hy8	284	2	protection	protection	NN
cord-011917-6u0t4hy8	284	3	magnify	magnify	VB
cord-011917-6u0t4hy8	284	4	.	.	.
cord-011917-6u0t4hy8	285	1	Before	before	IN
cord-011917-6u0t4hy8	285	2	this	this	DT
cord-011917-6u0t4hy8	285	3	reagent	reagent	NN
cord-011917-6u0t4hy8	285	4	development	development	NN
cord-011917-6u0t4hy8	285	5	,	,	,
cord-011917-6u0t4hy8	285	6	research	research	NN
cord-011917-6u0t4hy8	285	7	was	be	VBD
cord-011917-6u0t4hy8	285	8	limited	limit	VBN
cord-011917-6u0t4hy8	285	9	to	to	IN
cord-011917-6u0t4hy8	285	10	characterizing	characterize	VBG
cord-011917-6u0t4hy8	285	11	serum	serum	NN
cord-011917-6u0t4hy8	285	12	and	and	CC
cord-011917-6u0t4hy8	285	13	nasal	nasal	NN
cord-011917-6u0t4hy8	285	14	washes	wash	NNS
cord-011917-6u0t4hy8	285	15	for	for	IN
cord-011917-6u0t4hy8	285	16	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	285	17	antibodies	antibody	NNS
cord-011917-6u0t4hy8	285	18	and	and	CC
cord-011917-6u0t4hy8	285	19	measuring	measure	VBG
cord-011917-6u0t4hy8	285	20	clinical	clinical	JJ
cord-011917-6u0t4hy8	285	21	signs	sign	NNS
cord-011917-6u0t4hy8	285	22	after	after	IN
cord-011917-6u0t4hy8	285	23	infection	infection	NN
cord-011917-6u0t4hy8	285	24	.	.	.
cord-011917-6u0t4hy8	286	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	286	2	,	,	,
cord-011917-6u0t4hy8	286	3	future	future	JJ
cord-011917-6u0t4hy8	286	4	studies	study	NNS
cord-011917-6u0t4hy8	286	5	can	can	MD
cord-011917-6u0t4hy8	286	6	capture	capture	VB
cord-011917-6u0t4hy8	286	7	the	the	DT
cord-011917-6u0t4hy8	286	8	cellular	cellular	JJ
cord-011917-6u0t4hy8	286	9	immune	immune	JJ
cord-011917-6u0t4hy8	286	10	reactions	reaction	NNS
cord-011917-6u0t4hy8	286	11	of	of	IN
cord-011917-6u0t4hy8	286	12	T	t	NN
cord-011917-6u0t4hy8	286	13	-	-	HYPH
cord-011917-6u0t4hy8	286	14	cell	cell	NN
cord-011917-6u0t4hy8	286	15	responses	response	NNS
cord-011917-6u0t4hy8	286	16	with	with	IN
cord-011917-6u0t4hy8	286	17	IFN	IFN	NNP
cord-011917-6u0t4hy8	286	18	-	-	HYPH
cord-011917-6u0t4hy8	286	19	γ	γ	NN
cord-011917-6u0t4hy8	286	20	ELISAs	elisa	NNS
cord-011917-6u0t4hy8	286	21	[	[	-LRB-
cord-011917-6u0t4hy8	286	22	120	120	CD
cord-011917-6u0t4hy8	286	23	]	]	-RRB-
cord-011917-6u0t4hy8	286	24	,	,	,
cord-011917-6u0t4hy8	286	25	peripheral	peripheral	JJ
cord-011917-6u0t4hy8	286	26	blood	blood	NN
cord-011917-6u0t4hy8	286	27	leukocyte	leukocyte	NN
cord-011917-6u0t4hy8	286	28	tracking	tracking	NN
cord-011917-6u0t4hy8	286	29	[	[	-LRB-
cord-011917-6u0t4hy8	286	30	121	121	CD
cord-011917-6u0t4hy8	286	31	]	]	-RRB-
cord-011917-6u0t4hy8	286	32	,	,	,
cord-011917-6u0t4hy8	286	33	and	and	CC
cord-011917-6u0t4hy8	286	34	ELISpots	ELISpots	NNP
cord-011917-6u0t4hy8	286	35	[	[	-LRB-
cord-011917-6u0t4hy8	286	36	88	88	CD
cord-011917-6u0t4hy8	286	37	,	,	,
cord-011917-6u0t4hy8	286	38	122	122	CD
cord-011917-6u0t4hy8	286	39	]	]	-RRB-
cord-011917-6u0t4hy8	286	40	,	,	,
cord-011917-6u0t4hy8	286	41	as	as	RB
cord-011917-6u0t4hy8	286	42	well	well	RB
cord-011917-6u0t4hy8	286	43	as	as	IN
cord-011917-6u0t4hy8	286	44	the	the	DT
cord-011917-6u0t4hy8	286	45	humoral	humoral	JJ
cord-011917-6u0t4hy8	286	46	immunity	immunity	NN
cord-011917-6u0t4hy8	286	47	[	[	-LRB-
cord-011917-6u0t4hy8	286	48	18	18	CD
cord-011917-6u0t4hy8	286	49	,	,	,
cord-011917-6u0t4hy8	286	50	92	92	CD
cord-011917-6u0t4hy8	286	51	,	,	,
cord-011917-6u0t4hy8	286	52	123	123	CD
cord-011917-6u0t4hy8	286	53	,	,	,
cord-011917-6u0t4hy8	286	54	124	124	CD
cord-011917-6u0t4hy8	286	55	]	]	-RRB-
cord-011917-6u0t4hy8	286	56	.	.	.
cord-011917-6u0t4hy8	287	1	The	the	DT
cord-011917-6u0t4hy8	287	2	pre	pre	JJ
cord-011917-6u0t4hy8	287	3	-	-	JJ
cord-011917-6u0t4hy8	287	4	immune	immune	JJ
cord-011917-6u0t4hy8	287	5	ferret	ferret	NN
cord-011917-6u0t4hy8	287	6	model	model	NN
cord-011917-6u0t4hy8	287	7	is	be	VBZ
cord-011917-6u0t4hy8	287	8	within	within	IN
cord-011917-6u0t4hy8	287	9	its	-PRON-	PRP$
cord-011917-6u0t4hy8	287	10	early	early	JJ
cord-011917-6u0t4hy8	287	11	stages	stage	NNS
cord-011917-6u0t4hy8	287	12	of	of	IN
cord-011917-6u0t4hy8	287	13	development	development	NN
cord-011917-6u0t4hy8	287	14	;	;	:
cord-011917-6u0t4hy8	287	15	to	to	TO
cord-011917-6u0t4hy8	287	16	become	become	VB
cord-011917-6u0t4hy8	287	17	a	a	DT
cord-011917-6u0t4hy8	287	18	mainstay	mainstay	NN
cord-011917-6u0t4hy8	287	19	within	within	IN
cord-011917-6u0t4hy8	287	20	the	the	DT
cord-011917-6u0t4hy8	287	21	scientific	scientific	JJ
cord-011917-6u0t4hy8	287	22	community	community	NN
cord-011917-6u0t4hy8	287	23	and	and	CC
cord-011917-6u0t4hy8	287	24	used	use	VBD
cord-011917-6u0t4hy8	287	25	reliably	reliably	RB
cord-011917-6u0t4hy8	287	26	in	in	IN
cord-011917-6u0t4hy8	287	27	the	the	DT
cord-011917-6u0t4hy8	287	28	context	context	NN
cord-011917-6u0t4hy8	287	29	of	of	IN
cord-011917-6u0t4hy8	287	30	influenza	influenza	NN
cord-011917-6u0t4hy8	287	31	virus	virus	NN
cord-011917-6u0t4hy8	287	32	research	research	NN
cord-011917-6u0t4hy8	287	33	,	,	,
cord-011917-6u0t4hy8	287	34	the	the	DT
cord-011917-6u0t4hy8	287	35	baseline	baseline	JJ
cord-011917-6u0t4hy8	287	36	effects	effect	NNS
cord-011917-6u0t4hy8	287	37	of	of	IN
cord-011917-6u0t4hy8	287	38	infection	infection	NN
cord-011917-6u0t4hy8	287	39	,	,	,
cord-011917-6u0t4hy8	287	40	re	re	NN
cord-011917-6u0t4hy8	287	41	-	-	NN
cord-011917-6u0t4hy8	287	42	infection	infection	NN
cord-011917-6u0t4hy8	287	43	,	,	,
cord-011917-6u0t4hy8	287	44	and	and	CC
cord-011917-6u0t4hy8	287	45	vaccination	vaccination	NN
cord-011917-6u0t4hy8	287	46	within	within	IN
cord-011917-6u0t4hy8	287	47	the	the	DT
cord-011917-6u0t4hy8	287	48	ferret	ferret	NN
cord-011917-6u0t4hy8	287	49	need	need	NN
cord-011917-6u0t4hy8	287	50	to	to	TO
cord-011917-6u0t4hy8	287	51	be	be	VB
cord-011917-6u0t4hy8	287	52	addressed	address	VBN
cord-011917-6u0t4hy8	287	53	first	first	RB
cord-011917-6u0t4hy8	287	54	.	.	.
cord-011917-6u0t4hy8	288	1	This	this	DT
cord-011917-6u0t4hy8	288	2	involves	involve	VBZ
cord-011917-6u0t4hy8	288	3	determining	determine	VBG
cord-011917-6u0t4hy8	288	4	the	the	DT
cord-011917-6u0t4hy8	288	5	cool	cool	JJ
cord-011917-6u0t4hy8	288	6	-	-	HYPH
cord-011917-6u0t4hy8	288	7	down	down	RP
cord-011917-6u0t4hy8	288	8	time	time	NN
cord-011917-6u0t4hy8	288	9	of	of	IN
cord-011917-6u0t4hy8	288	10	the	the	DT
cord-011917-6u0t4hy8	288	11	ferret	ferret	JJ
cord-011917-6u0t4hy8	288	12	immune	immune	JJ
cord-011917-6u0t4hy8	288	13	system	system	NN
cord-011917-6u0t4hy8	288	14	following	follow	VBG
cord-011917-6u0t4hy8	288	15	infection	infection	NN
cord-011917-6u0t4hy8	288	16	and	and	CC
cord-011917-6u0t4hy8	288	17	the	the	DT
cord-011917-6u0t4hy8	288	18	differences	difference	NNS
cord-011917-6u0t4hy8	288	19	compared	compare	VBN
cord-011917-6u0t4hy8	288	20	to	to	IN
cord-011917-6u0t4hy8	288	21	a	a	DT
cord-011917-6u0t4hy8	288	22	vaccination	vaccination	NN
cord-011917-6u0t4hy8	288	23	.	.	.
cord-011917-6u0t4hy8	289	1	Furthermore	furthermore	RB
cord-011917-6u0t4hy8	289	2	,	,	,
cord-011917-6u0t4hy8	289	3	studies	study	NNS
cord-011917-6u0t4hy8	289	4	of	of	IN
cord-011917-6u0t4hy8	289	5	the	the	DT
cord-011917-6u0t4hy8	289	6	different	different	JJ
cord-011917-6u0t4hy8	289	7	immunological	immunological	JJ
cord-011917-6u0t4hy8	289	8	ferret	ferret	NN
cord-011917-6u0t4hy8	289	9	responses	response	NNS
cord-011917-6u0t4hy8	289	10	such	such	JJ
cord-011917-6u0t4hy8	289	11	as	as	IN
cord-011917-6u0t4hy8	289	12	cytokine	cytokine	JJ
cord-011917-6u0t4hy8	289	13	quantity	quantity	NN
cord-011917-6u0t4hy8	289	14	and	and	CC
cord-011917-6u0t4hy8	289	15	diversity	diversity	NN
cord-011917-6u0t4hy8	289	16	,	,	,
cord-011917-6u0t4hy8	289	17	B	b	NN
cord-011917-6u0t4hy8	289	18	-	-	:
cord-011917-6u0t4hy8	289	19	and	and	CC
cord-011917-6u0t4hy8	289	20	T	t	NN
cord-011917-6u0t4hy8	289	21	-	-	HYPH
cord-011917-6u0t4hy8	289	22	cell	cell	NN
cord-011917-6u0t4hy8	289	23	repertoire	repertoire	NN
cord-011917-6u0t4hy8	289	24	,	,	,
cord-011917-6u0t4hy8	289	25	and	and	CC
cord-011917-6u0t4hy8	289	26	B	b	NN
cord-011917-6u0t4hy8	289	27	-	-	:
cord-011917-6u0t4hy8	289	28	and	and	CC
cord-011917-6u0t4hy8	289	29	T	t	NN
cord-011917-6u0t4hy8	289	30	-	-	HYPH
cord-011917-6u0t4hy8	289	31	cell	cell	NN
cord-011917-6u0t4hy8	289	32	recall	recall	NN
cord-011917-6u0t4hy8	289	33	responses	response	NNS
cord-011917-6u0t4hy8	289	34	are	be	VBP
cord-011917-6u0t4hy8	289	35	important	important	JJ
cord-011917-6u0t4hy8	289	36	to	to	TO
cord-011917-6u0t4hy8	289	37	characterize	characterize	VB
cord-011917-6u0t4hy8	289	38	.	.	.
cord-011917-6u0t4hy8	290	1	In	in	IN
cord-011917-6u0t4hy8	290	2	addition	addition	NN
cord-011917-6u0t4hy8	290	3	,	,	,
cord-011917-6u0t4hy8	290	4	advancements	advancement	NNS
cord-011917-6u0t4hy8	290	5	in	in	IN
cord-011917-6u0t4hy8	290	6	high	high	JJ
cord-011917-6u0t4hy8	290	7	-	-	HYPH
cord-011917-6u0t4hy8	290	8	throughput	throughput	NN
cord-011917-6u0t4hy8	290	9	,	,	,
cord-011917-6u0t4hy8	290	10	single	single	JJ
cord-011917-6u0t4hy8	290	11	cell	cell	NN
cord-011917-6u0t4hy8	290	12	sequencing	sequencing	NN
cord-011917-6u0t4hy8	290	13	technology	technology	NN
cord-011917-6u0t4hy8	290	14	allow	allow	VBP
cord-011917-6u0t4hy8	290	15	depiction	depiction	NN
cord-011917-6u0t4hy8	290	16	of	of	IN
cord-011917-6u0t4hy8	290	17	the	the	DT
cord-011917-6u0t4hy8	290	18	B	b	NN
cord-011917-6u0t4hy8	290	19	-	-	HYPH
cord-011917-6u0t4hy8	290	20	cell	cell	NN
cord-011917-6u0t4hy8	290	21	evolution	evolution	NN
cord-011917-6u0t4hy8	290	22	from	from	IN
cord-011917-6u0t4hy8	290	23	a	a	DT
cord-011917-6u0t4hy8	290	24	single	single	JJ
cord-011917-6u0t4hy8	290	25	ancestral	ancestral	JJ
cord-011917-6u0t4hy8	290	26	B	b	NN
cord-011917-6u0t4hy8	290	27	-	-	HYPH
cord-011917-6u0t4hy8	290	28	cell	cell	NN
cord-011917-6u0t4hy8	290	29	[	[	-LRB-
cord-011917-6u0t4hy8	290	30	124	124	CD
cord-011917-6u0t4hy8	290	31	]	]	-RRB-
cord-011917-6u0t4hy8	290	32	.	.	.
cord-011917-6u0t4hy8	291	1	The	the	DT
cord-011917-6u0t4hy8	291	2	ferret	ferret	JJ
cord-011917-6u0t4hy8	291	3	model	model	NN
cord-011917-6u0t4hy8	291	4	is	be	VBZ
cord-011917-6u0t4hy8	291	5	used	use	VBN
cord-011917-6u0t4hy8	291	6	to	to	TO
cord-011917-6u0t4hy8	291	7	study	study	VB
cord-011917-6u0t4hy8	291	8	influenza	influenza	NN
cord-011917-6u0t4hy8	291	9	virus	virus	NN
cord-011917-6u0t4hy8	291	10	infection	infection	NN
cord-011917-6u0t4hy8	291	11	because	because	IN
cord-011917-6u0t4hy8	291	12	of	of	IN
cord-011917-6u0t4hy8	291	13	the	the	DT
cord-011917-6u0t4hy8	291	14	ferret	ferret	NN
cord-011917-6u0t4hy8	291	15	's	's	POS
cord-011917-6u0t4hy8	291	16	natural	natural	JJ
cord-011917-6u0t4hy8	291	17	susceptibility	susceptibility	NN
cord-011917-6u0t4hy8	291	18	,	,	,
cord-011917-6u0t4hy8	291	19	shared	share	VBD
cord-011917-6u0t4hy8	291	20	clinical	clinical	JJ
cord-011917-6u0t4hy8	291	21	signs	sign	NNS
cord-011917-6u0t4hy8	291	22	of	of	IN
cord-011917-6u0t4hy8	291	23	illness	illness	NN
cord-011917-6u0t4hy8	291	24	,	,	,
cord-011917-6u0t4hy8	291	25	and	and	CC
cord-011917-6u0t4hy8	291	26	possession	possession	NN
cord-011917-6u0t4hy8	291	27	of	of	IN
cord-011917-6u0t4hy8	291	28	similarities	similarity	NNS
cord-011917-6u0t4hy8	291	29	in	in	IN
cord-011917-6u0t4hy8	291	30	respiratory	respiratory	JJ
cord-011917-6u0t4hy8	291	31	physiology	physiology	NN
cord-011917-6u0t4hy8	291	32	,	,	,
cord-011917-6u0t4hy8	291	33	cell	cell	NN
cord-011917-6u0t4hy8	291	34	composition	composition	NN
cord-011917-6u0t4hy8	291	35	,	,	,
cord-011917-6u0t4hy8	291	36	and	and	CC
cord-011917-6u0t4hy8	291	37	distribution	distribution	NN
cord-011917-6u0t4hy8	291	38	of	of	IN
cord-011917-6u0t4hy8	291	39	sialic	sialic	JJ
cord-011917-6u0t4hy8	291	40	acid	acid	NN
cord-011917-6u0t4hy8	291	41	receptors	receptor	NNS
cord-011917-6u0t4hy8	291	42	.	.	.
cord-011917-6u0t4hy8	292	1	Although	although	IN
cord-011917-6u0t4hy8	292	2	present	present	JJ
cord-011917-6u0t4hy8	292	3	,	,	,
cord-011917-6u0t4hy8	292	4	these	these	DT
cord-011917-6u0t4hy8	292	5	components	component	NNS
cord-011917-6u0t4hy8	292	6	may	may	MD
cord-011917-6u0t4hy8	292	7	not	not	RB
cord-011917-6u0t4hy8	292	8	interact	interact	VB
cord-011917-6u0t4hy8	292	9	in	in	IN
cord-011917-6u0t4hy8	292	10	the	the	DT
cord-011917-6u0t4hy8	292	11	same	same	JJ
cord-011917-6u0t4hy8	292	12	manner	manner	NN
cord-011917-6u0t4hy8	292	13	as	as	IN
cord-011917-6u0t4hy8	292	14	human	human	JJ
cord-011917-6u0t4hy8	292	15	immune	immune	NN
cord-011917-6u0t4hy8	292	16	system	system	NN
cord-011917-6u0t4hy8	292	17	following	follow	VBG
cord-011917-6u0t4hy8	292	18	influenza	influenza	NN
cord-011917-6u0t4hy8	292	19	virus	virus	NN
cord-011917-6u0t4hy8	292	20	infection	infection	NN
cord-011917-6u0t4hy8	292	21	[	[	-LRB-
cord-011917-6u0t4hy8	292	22	78	78	CD
cord-011917-6u0t4hy8	292	23	]	]	-RRB-
cord-011917-6u0t4hy8	292	24	.	.	.
cord-011917-6u0t4hy8	293	1	Comparisons	comparison	NNS
cord-011917-6u0t4hy8	293	2	of	of	IN
cord-011917-6u0t4hy8	293	3	different	different	JJ
cord-011917-6u0t4hy8	293	4	pre	pre	JJ
cord-011917-6u0t4hy8	293	5	-	-	JJ
cord-011917-6u0t4hy8	293	6	immune	immune	JJ
cord-011917-6u0t4hy8	293	7	influenza	influenza	NN
cord-011917-6u0t4hy8	293	8	animal	animal	NN
cord-011917-6u0t4hy8	293	9	models	model	NNS
cord-011917-6u0t4hy8	293	10	(	(	-LRB-
cord-011917-6u0t4hy8	293	11	mice	mouse	NNS
cord-011917-6u0t4hy8	293	12	,	,	,
cord-011917-6u0t4hy8	293	13	guinea	guinea	NN
cord-011917-6u0t4hy8	293	14	pigs	pig	NNS
cord-011917-6u0t4hy8	293	15	,	,	,
cord-011917-6u0t4hy8	293	16	and	and	CC
cord-011917-6u0t4hy8	293	17	ferrets	ferret	NNS
cord-011917-6u0t4hy8	293	18	)	)	-RRB-
cord-011917-6u0t4hy8	293	19	to	to	IN
cord-011917-6u0t4hy8	293	20	human	human	JJ
cord-011917-6u0t4hy8	293	21	serology	serology	NN
cord-011917-6u0t4hy8	293	22	data	datum	NNS
cord-011917-6u0t4hy8	293	23	emphasized	emphasize	VBD
cord-011917-6u0t4hy8	293	24	that	that	IN
cord-011917-6u0t4hy8	293	25	the	the	DT
cord-011917-6u0t4hy8	293	26	use	use	NN
cord-011917-6u0t4hy8	293	27	of	of	IN
cord-011917-6u0t4hy8	293	28	different	different	JJ
cord-011917-6u0t4hy8	293	29	animal	animal	NN
cord-011917-6u0t4hy8	293	30	models	model	NNS
cord-011917-6u0t4hy8	293	31	should	should	MD
cord-011917-6u0t4hy8	293	32	be	be	VB
cord-011917-6u0t4hy8	293	33	heavily	heavily	RB
cord-011917-6u0t4hy8	293	34	considered	consider	VBN
cord-011917-6u0t4hy8	293	35	for	for	IN
cord-011917-6u0t4hy8	293	36	pre	pre	JJ
cord-011917-6u0t4hy8	293	37	-	-	JJ
cord-011917-6u0t4hy8	293	38	clinical	clinical	JJ
cord-011917-6u0t4hy8	293	39	vaccine	vaccine	NN
cord-011917-6u0t4hy8	293	40	studies	study	NNS
cord-011917-6u0t4hy8	293	41	due	due	JJ
cord-011917-6u0t4hy8	293	42	to	to	IN
cord-011917-6u0t4hy8	293	43	the	the	DT
cord-011917-6u0t4hy8	293	44	biases	bias	NNS
cord-011917-6u0t4hy8	293	45	between	between	IN
cord-011917-6u0t4hy8	293	46	them	-PRON-	PRP
cord-011917-6u0t4hy8	293	47	.	.	.
cord-011917-6u0t4hy8	294	1	Basic	basic	JJ
cord-011917-6u0t4hy8	294	2	research	research	NN
cord-011917-6u0t4hy8	294	3	of	of	IN
cord-011917-6u0t4hy8	294	4	the	the	DT
cord-011917-6u0t4hy8	294	5	ferret	ferret	JJ
cord-011917-6u0t4hy8	294	6	physiology	physiology	NN
cord-011917-6u0t4hy8	294	7	can	can	MD
cord-011917-6u0t4hy8	294	8	be	be	VB
cord-011917-6u0t4hy8	294	9	compared	compare	VBN
cord-011917-6u0t4hy8	294	10	and	and	CC
cord-011917-6u0t4hy8	294	11	validated	validate	VBN
cord-011917-6u0t4hy8	294	12	against	against	IN
cord-011917-6u0t4hy8	294	13	data	datum	NNS
cord-011917-6u0t4hy8	294	14	from	from	IN
cord-011917-6u0t4hy8	294	15	human	human	JJ
cord-011917-6u0t4hy8	294	16	studies	study	NNS
cord-011917-6u0t4hy8	294	17	.	.	.
cord-011917-6u0t4hy8	295	1	Cross	cross	NN
cord-011917-6u0t4hy8	295	2	-	-	NN
cord-011917-6u0t4hy8	295	3	validation	validation	NN
cord-011917-6u0t4hy8	295	4	will	will	MD
cord-011917-6u0t4hy8	295	5	either	either	CC
cord-011917-6u0t4hy8	295	6	bolster	bolster	VB
cord-011917-6u0t4hy8	295	7	the	the	DT
cord-011917-6u0t4hy8	295	8	ferret	ferret	JJ
cord-011917-6u0t4hy8	295	9	findings	finding	NNS
cord-011917-6u0t4hy8	295	10	or	or	CC
cord-011917-6u0t4hy8	295	11	they	-PRON-	PRP
cord-011917-6u0t4hy8	295	12	will	will	MD
cord-011917-6u0t4hy8	295	13	provide	provide	VB
cord-011917-6u0t4hy8	295	14	researchers	researcher	NNS
cord-011917-6u0t4hy8	295	15	the	the	DT
cord-011917-6u0t4hy8	295	16	ability	ability	NN
cord-011917-6u0t4hy8	295	17	to	to	TO
cord-011917-6u0t4hy8	295	18	determine	determine	VB
cord-011917-6u0t4hy8	295	19	which	which	WDT
cord-011917-6u0t4hy8	295	20	immunological	immunological	JJ
cord-011917-6u0t4hy8	295	21	findings	finding	NNS
cord-011917-6u0t4hy8	295	22	are	be	VBP
cord-011917-6u0t4hy8	295	23	relevant	relevant	JJ
cord-011917-6u0t4hy8	295	24	for	for	IN
cord-011917-6u0t4hy8	295	25	further	further	JJ
cord-011917-6u0t4hy8	295	26	investigation	investigation	NN
cord-011917-6u0t4hy8	295	27	and	and	CC
cord-011917-6u0t4hy8	295	28	which	which	WDT
cord-011917-6u0t4hy8	295	29	are	be	VBP
cord-011917-6u0t4hy8	295	30	solely	solely	RB
cord-011917-6u0t4hy8	295	31	ferret	ferret	JJ
cord-011917-6u0t4hy8	295	32	-	-	HYPH
cord-011917-6u0t4hy8	295	33	specific	specific	JJ
cord-011917-6u0t4hy8	295	34	phenomena	phenomenon	NNS
cord-011917-6u0t4hy8	295	35	.	.	.
cord-011917-6u0t4hy8	296	1	This	this	DT
cord-011917-6u0t4hy8	296	2	process	process	NN
cord-011917-6u0t4hy8	296	3	focuses	focus	VBZ
cord-011917-6u0t4hy8	296	4	on	on	IN
cord-011917-6u0t4hy8	296	5	the	the	DT
cord-011917-6u0t4hy8	296	6	ferret	ferret	NN
cord-011917-6u0t4hy8	296	7	model	model	NN
cord-011917-6u0t4hy8	296	8	being	be	VBG
cord-011917-6u0t4hy8	296	9	a	a	DT
cord-011917-6u0t4hy8	296	10	surrogate	surrogate	NN
cord-011917-6u0t4hy8	296	11	for	for	IN
cord-011917-6u0t4hy8	296	12	the	the	DT
cord-011917-6u0t4hy8	296	13	human	human	NN
cord-011917-6u0t4hy8	296	14	.	.	.
cord-011917-6u0t4hy8	297	1	The	the	DT
cord-011917-6u0t4hy8	297	2	decision	decision	NN
cord-011917-6u0t4hy8	297	3	-	-	HYPH
cord-011917-6u0t4hy8	297	4	making	make	VBG
cord-011917-6u0t4hy8	297	5	process	process	NN
cord-011917-6u0t4hy8	297	6	of	of	IN
cord-011917-6u0t4hy8	297	7	vaccine	vaccine	NN
cord-011917-6u0t4hy8	297	8	selection	selection	NN
cord-011917-6u0t4hy8	297	9	and	and	CC
cord-011917-6u0t4hy8	297	10	therapeutics	therapeutics	NN
cord-011917-6u0t4hy8	297	11	relies	rely	VBZ
cord-011917-6u0t4hy8	297	12	on	on	IN
cord-011917-6u0t4hy8	297	13	the	the	DT
cord-011917-6u0t4hy8	297	14	ferret	ferret	NN
cord-011917-6u0t4hy8	297	15	,	,	,
cord-011917-6u0t4hy8	297	16	and	and	CC
cord-011917-6u0t4hy8	297	17	it	-PRON-	PRP
cord-011917-6u0t4hy8	297	18	is	be	VBZ
cord-011917-6u0t4hy8	297	19	important	important	JJ
cord-011917-6u0t4hy8	297	20	that	that	IN
cord-011917-6u0t4hy8	297	21	human	human	JJ
cord-011917-6u0t4hy8	297	22	-	-	HYPH
cord-011917-6u0t4hy8	297	23	ferret	ferret	NN
cord-011917-6u0t4hy8	297	24	shared	share	VBN
cord-011917-6u0t4hy8	297	25	traits	trait	NNS
cord-011917-6u0t4hy8	297	26	are	be	VBP
cord-011917-6u0t4hy8	297	27	appropriately	appropriately	RB
cord-011917-6u0t4hy8	297	28	distinguished	distinguished	JJ
cord-011917-6u0t4hy8	297	29	.	.	.
cord-011917-6u0t4hy8	298	1	Therefore	therefore	RB
cord-011917-6u0t4hy8	298	2	,	,	,
cord-011917-6u0t4hy8	298	3	further	further	JJ
cord-011917-6u0t4hy8	298	4	study	study	NN
cord-011917-6u0t4hy8	298	5	,	,	,
cord-011917-6u0t4hy8	298	6	comparison	comparison	NN
cord-011917-6u0t4hy8	298	7	,	,	,
cord-011917-6u0t4hy8	298	8	and	and	CC
cord-011917-6u0t4hy8	298	9	validation	validation	NN
cord-011917-6u0t4hy8	298	10	are	be	VBP
cord-011917-6u0t4hy8	298	11	needed	need	VBN
cord-011917-6u0t4hy8	298	12	to	to	TO
cord-011917-6u0t4hy8	298	13	fully	fully	RB
cord-011917-6u0t4hy8	298	14	grasp	grasp	VB
cord-011917-6u0t4hy8	298	15	the	the	DT
cord-011917-6u0t4hy8	298	16	predispositions	predisposition	NNS
cord-011917-6u0t4hy8	298	17	and	and	CC
cord-011917-6u0t4hy8	298	18	limitations	limitation	NNS
cord-011917-6u0t4hy8	298	19	of	of	IN
cord-011917-6u0t4hy8	298	20	the	the	DT
cord-011917-6u0t4hy8	298	21	model	model	NN
cord-011917-6u0t4hy8	298	22	.	.	.
cord-011917-6u0t4hy8	299	1	Although	although	IN
cord-011917-6u0t4hy8	299	2	initially	initially	RB
cord-011917-6u0t4hy8	299	3	developed	develop	VBN
cord-011917-6u0t4hy8	299	4	in	in	IN
cord-011917-6u0t4hy8	299	5	the	the	DT
cord-011917-6u0t4hy8	299	6	1970s	1970	NNS
cord-011917-6u0t4hy8	299	7	,	,	,
cord-011917-6u0t4hy8	299	8	recently	recently	RB
cord-011917-6u0t4hy8	299	9	,	,	,
cord-011917-6u0t4hy8	299	10	the	the	DT
cord-011917-6u0t4hy8	299	11	pre	pre	JJ
cord-011917-6u0t4hy8	299	12	-	-	JJ
cord-011917-6u0t4hy8	299	13	immune	immune	JJ
cord-011917-6u0t4hy8	299	14	ferret	ferret	NN
cord-011917-6u0t4hy8	299	15	model	model	NN
cord-011917-6u0t4hy8	299	16	has	have	VBZ
cord-011917-6u0t4hy8	299	17	rapidly	rapidly	RB
cord-011917-6u0t4hy8	299	18	progressed	progress	VBN
cord-011917-6u0t4hy8	299	19	into	into	IN
cord-011917-6u0t4hy8	299	20	a	a	DT
cord-011917-6u0t4hy8	299	21	vital	vital	JJ
cord-011917-6u0t4hy8	299	22	tool	tool	NN
cord-011917-6u0t4hy8	299	23	for	for	IN
cord-011917-6u0t4hy8	299	24	the	the	DT
cord-011917-6u0t4hy8	299	25	development	development	NN
cord-011917-6u0t4hy8	299	26	of	of	IN
cord-011917-6u0t4hy8	299	27	a	a	DT
cord-011917-6u0t4hy8	299	28	broadly	broadly	RB
cord-011917-6u0t4hy8	299	29	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	299	30	influenza	influenza	NN
cord-011917-6u0t4hy8	299	31	vaccine	vaccine	NN
cord-011917-6u0t4hy8	299	32	.	.	.
cord-011917-6u0t4hy8	300	1	In	in	IN
cord-011917-6u0t4hy8	300	2	conclusion	conclusion	NN
cord-011917-6u0t4hy8	300	3	,	,	,
cord-011917-6u0t4hy8	300	4	care	care	NN
cord-011917-6u0t4hy8	300	5	needs	need	NNS
cord-011917-6u0t4hy8	300	6	to	to	TO
cord-011917-6u0t4hy8	300	7	be	be	VB
cord-011917-6u0t4hy8	300	8	taken	take	VBN
cord-011917-6u0t4hy8	300	9	to	to	TO
cord-011917-6u0t4hy8	300	10	begin	begin	VB
cord-011917-6u0t4hy8	300	11	planning	plan	VBG
cord-011917-6u0t4hy8	300	12	studies	study	NNS
cord-011917-6u0t4hy8	300	13	to	to	TO
cord-011917-6u0t4hy8	300	14	incorporate	incorporate	VB
cord-011917-6u0t4hy8	300	15	the	the	DT
cord-011917-6u0t4hy8	300	16	effects	effect	NNS
cord-011917-6u0t4hy8	300	17	of	of	IN
cord-011917-6u0t4hy8	300	18	imprinting	imprinting	NN
cord-011917-6u0t4hy8	300	19	and	and	CC
cord-011917-6u0t4hy8	300	20	pre	pre	JJ
cord-011917-6u0t4hy8	300	21	-	-	NN
cord-011917-6u0t4hy8	300	22	immunity	immunity	NN
cord-011917-6u0t4hy8	300	23	within	within	IN
cord-011917-6u0t4hy8	300	24	the	the	DT
cord-011917-6u0t4hy8	300	25	animal	animal	NN
cord-011917-6u0t4hy8	300	26	model	model	NN
cord-011917-6u0t4hy8	300	27	to	to	TO
cord-011917-6u0t4hy8	300	28	apply	apply	VB
cord-011917-6u0t4hy8	300	29	the	the	DT
cord-011917-6u0t4hy8	300	30	results	result	NNS
cord-011917-6u0t4hy8	300	31	to	to	IN
cord-011917-6u0t4hy8	300	32	the	the	DT
cord-011917-6u0t4hy8	300	33	human	human	JJ
cord-011917-6u0t4hy8	300	34	system	system	NN
cord-011917-6u0t4hy8	300	35	.	.	.
cord-011917-6u0t4hy8	301	1	Animal	animal	NN
cord-011917-6u0t4hy8	301	2	models	model	NNS
cord-011917-6u0t4hy8	301	3	used	use	VBN
cord-011917-6u0t4hy8	301	4	for	for	IN
cord-011917-6u0t4hy8	301	5	influenza	influenza	NN
cord-011917-6u0t4hy8	301	6	research	research	NN
cord-011917-6u0t4hy8	301	7	are	be	VBP
cord-011917-6u0t4hy8	301	8	available	available	JJ
cord-011917-6u0t4hy8	301	9	and	and	CC
cord-011917-6u0t4hy8	301	10	widely	widely	RB
cord-011917-6u0t4hy8	301	11	use	use	NN
cord-011917-6u0t4hy8	301	12	.	.	.
cord-011917-6u0t4hy8	302	1	However	however	RB
cord-011917-6u0t4hy8	302	2	,	,	,
cord-011917-6u0t4hy8	302	3	as	as	IN
cord-011917-6u0t4hy8	302	4	more	more	JJR
cord-011917-6u0t4hy8	302	5	findings	finding	NNS
cord-011917-6u0t4hy8	302	6	and	and	CC
cord-011917-6u0t4hy8	302	7	reagents	reagent	NNS
cord-011917-6u0t4hy8	302	8	become	become	VBP
cord-011917-6u0t4hy8	302	9	available	available	JJ
cord-011917-6u0t4hy8	302	10	,	,	,
cord-011917-6u0t4hy8	302	11	the	the	DT
cord-011917-6u0t4hy8	302	12	models	model	NNS
cord-011917-6u0t4hy8	302	13	need	need	VBP
cord-011917-6u0t4hy8	302	14	to	to	TO
cord-011917-6u0t4hy8	302	15	be	be	VB
cord-011917-6u0t4hy8	302	16	updated	update	VBN
cord-011917-6u0t4hy8	302	17	appropriately	appropriately	RB
cord-011917-6u0t4hy8	302	18	.	.	.
cord-011917-6u0t4hy8	303	1	In	in	IN
cord-011917-6u0t4hy8	303	2	addition	addition	NN
cord-011917-6u0t4hy8	303	3	,	,	,
cord-011917-6u0t4hy8	303	4	more	more	JJR
cord-011917-6u0t4hy8	303	5	research	research	NN
cord-011917-6u0t4hy8	303	6	on	on	IN
cord-011917-6u0t4hy8	303	7	the	the	DT
cord-011917-6u0t4hy8	303	8	immunological	immunological	JJ
cord-011917-6u0t4hy8	303	9	effects	effect	NNS
cord-011917-6u0t4hy8	303	10	of	of	IN
cord-011917-6u0t4hy8	303	11	imprinting	imprinting	NN
cord-011917-6u0t4hy8	303	12	in	in	IN
cord-011917-6u0t4hy8	303	13	ferrets	ferret	NNS
cord-011917-6u0t4hy8	303	14	,	,	,
cord-011917-6u0t4hy8	303	15	which	which	WDT
cord-011917-6u0t4hy8	303	16	is	be	VBZ
cord-011917-6u0t4hy8	303	17	then	then	RB
cord-011917-6u0t4hy8	303	18	compared	compare	VBN
cord-011917-6u0t4hy8	303	19	to	to	IN
cord-011917-6u0t4hy8	303	20	the	the	DT
cord-011917-6u0t4hy8	303	21	research	research	NN
cord-011917-6u0t4hy8	303	22	on	on	IN
cord-011917-6u0t4hy8	303	23	the	the	DT
cord-011917-6u0t4hy8	303	24	effects	effect	NNS
cord-011917-6u0t4hy8	303	25	of	of	IN
cord-011917-6u0t4hy8	303	26	imprinting	imprinting	NN
cord-011917-6u0t4hy8	303	27	on	on	IN
cord-011917-6u0t4hy8	303	28	humans	human	NNS
cord-011917-6u0t4hy8	303	29	,	,	,
cord-011917-6u0t4hy8	303	30	will	will	MD
cord-011917-6u0t4hy8	303	31	contribute	contribute	VB
cord-011917-6u0t4hy8	303	32	to	to	IN
cord-011917-6u0t4hy8	303	33	the	the	DT
cord-011917-6u0t4hy8	303	34	validation	validation	NN
cord-011917-6u0t4hy8	303	35	of	of	IN
cord-011917-6u0t4hy8	303	36	using	use	VBG
cord-011917-6u0t4hy8	303	37	the	the	DT
cord-011917-6u0t4hy8	303	38	ferret	ferret	NN
cord-011917-6u0t4hy8	303	39	as	as	IN
cord-011917-6u0t4hy8	303	40	an	an	DT
cord-011917-6u0t4hy8	303	41	appropriate	appropriate	JJ
cord-011917-6u0t4hy8	303	42	animal	animal	NN
cord-011917-6u0t4hy8	303	43	model	model	NN
cord-011917-6u0t4hy8	303	44	to	to	TO
cord-011917-6u0t4hy8	303	45	study	study	VB
cord-011917-6u0t4hy8	303	46	influenza	influenza	NN
cord-011917-6u0t4hy8	303	47	virus	virus	NN
cord-011917-6u0t4hy8	303	48	in	in	IN
cord-011917-6u0t4hy8	303	49	humans	human	NNS
cord-011917-6u0t4hy8	303	50	.	.	.
cord-011917-6u0t4hy8	304	1	Altogether	altogether	RB
cord-011917-6u0t4hy8	304	2	,	,	,
cord-011917-6u0t4hy8	304	3	the	the	DT
cord-011917-6u0t4hy8	304	4	major	major	JJ
cord-011917-6u0t4hy8	304	5	goal	goal	NN
cord-011917-6u0t4hy8	304	6	of	of	IN
cord-011917-6u0t4hy8	304	7	developing	develop	VBG
cord-011917-6u0t4hy8	304	8	a	a	DT
cord-011917-6u0t4hy8	304	9	broadly	broadly	RB
cord-011917-6u0t4hy8	304	10	neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	304	11	influenza	influenza	NN
cord-011917-6u0t4hy8	304	12	vaccine	vaccine	NN
cord-011917-6u0t4hy8	304	13	by	by	IN
cord-011917-6u0t4hy8	304	14	priming	prime	VBG
cord-011917-6u0t4hy8	304	15	the	the	DT
cord-011917-6u0t4hy8	304	16	immune	immune	JJ
cord-011917-6u0t4hy8	304	17	system	system	NN
cord-011917-6u0t4hy8	304	18	adequately	adequately	RB
cord-011917-6u0t4hy8	304	19	to	to	TO
cord-011917-6u0t4hy8	304	20	produce	produce	VB
cord-011917-6u0t4hy8	304	21	the	the	DT
cord-011917-6u0t4hy8	304	22	same	same	JJ
cord-011917-6u0t4hy8	304	23	sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	304	24	immunity	immunity	NN
cord-011917-6u0t4hy8	304	25	as	as	IN
cord-011917-6u0t4hy8	304	26	infection	infection	NN
cord-011917-6u0t4hy8	304	27	,	,	,
cord-011917-6u0t4hy8	304	28	but	but	CC
cord-011917-6u0t4hy8	304	29	without	without	IN
cord-011917-6u0t4hy8	304	30	the	the	DT
cord-011917-6u0t4hy8	304	31	deleterious	deleterious	JJ
cord-011917-6u0t4hy8	304	32	effects	effect	NNS
cord-011917-6u0t4hy8	304	33	,	,	,
cord-011917-6u0t4hy8	304	34	could	could	MD
cord-011917-6u0t4hy8	304	35	be	be	VB
cord-011917-6u0t4hy8	304	36	tested	test	VBN
cord-011917-6u0t4hy8	304	37	in	in	IN
cord-011917-6u0t4hy8	304	38	these	these	DT
cord-011917-6u0t4hy8	304	39	models	model	NNS
cord-011917-6u0t4hy8	304	40	.	.	.
cord-011917-6u0t4hy8	304	41	 	 	_SP
cord-011917-6u0t4hy8	305	1	Global	Global	NNP
cord-011917-6u0t4hy8	305	2	Seasonal	Seasonal	NNP
cord-011917-6u0t4hy8	305	3	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	305	4	-	-	HYPH
cord-011917-6u0t4hy8	305	5	Associated	Associated	NNP
cord-011917-6u0t4hy8	305	6	Mortality	Mortality	NNP
cord-011917-6u0t4hy8	305	7	Collaborator	Collaborator	NNP
cord-011917-6u0t4hy8	305	8	Network	Network	NNP
cord-011917-6u0t4hy8	305	9	;	;	:
cord-011917-6u0t4hy8	305	10	GLaMOR	GLaMOR	NNP
cord-011917-6u0t4hy8	305	11	Collaborating	Collaborating	NNP
cord-011917-6u0t4hy8	305	12	Teams	Teams	NNPS
cord-011917-6u0t4hy8	305	13	.	.	.
cord-011917-6u0t4hy8	306	1	Global	global	JJ
cord-011917-6u0t4hy8	306	2	mortality	mortality	NN
cord-011917-6u0t4hy8	306	3	associated	associate	VBN
cord-011917-6u0t4hy8	306	4	with	with	IN
cord-011917-6u0t4hy8	306	5	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	306	6	influenza	influenza	NN
cord-011917-6u0t4hy8	306	7	epidemics	epidemic	NNS
cord-011917-6u0t4hy8	306	8	:	:	:
cord-011917-6u0t4hy8	306	9	New	new	JJ
cord-011917-6u0t4hy8	306	10	burden	burden	NN
cord-011917-6u0t4hy8	306	11	estimates	estimate	NNS
cord-011917-6u0t4hy8	306	12	and	and	CC
cord-011917-6u0t4hy8	306	13	predictors	predictor	NNS
cord-011917-6u0t4hy8	306	14	from	from	IN
cord-011917-6u0t4hy8	306	15	the	the	DT
cord-011917-6u0t4hy8	306	16	GLaMOR	GLaMOR	NNP
cord-011917-6u0t4hy8	306	17	Project	Project	NNP
cord-011917-6u0t4hy8	307	1	A	a	DT
cord-011917-6u0t4hy8	307	2	distinct	distinct	JJ
cord-011917-6u0t4hy8	307	3	lineage	lineage	NN
cord-011917-6u0t4hy8	307	4	of	of	IN
cord-011917-6u0t4hy8	307	5	influenza	influenza	NN
cord-011917-6u0t4hy8	307	6	A	a	DT
cord-011917-6u0t4hy8	307	7	virus	virus	NN
cord-011917-6u0t4hy8	307	8	from	from	IN
cord-011917-6u0t4hy8	307	9	bats	bat	NNS
cord-011917-6u0t4hy8	308	1	The	the	DT
cord-011917-6u0t4hy8	308	2	establishment	establishment	NN
cord-011917-6u0t4hy8	308	3	of	of	IN
cord-011917-6u0t4hy8	308	4	surrogates	surrogate	NNS
cord-011917-6u0t4hy8	308	5	and	and	CC
cord-011917-6u0t4hy8	308	6	correlates	correlate	NNS
cord-011917-6u0t4hy8	308	7	of	of	IN
cord-011917-6u0t4hy8	308	8	protection	protection	NN
cord-011917-6u0t4hy8	308	9	:	:	:
cord-011917-6u0t4hy8	308	10	Useful	useful	JJ
cord-011917-6u0t4hy8	308	11	tools	tool	NNS
cord-011917-6u0t4hy8	308	12	for	for	IN
cord-011917-6u0t4hy8	308	13	the	the	DT
cord-011917-6u0t4hy8	308	14	licensure	licensure	NN
cord-011917-6u0t4hy8	308	15	of	of	IN
cord-011917-6u0t4hy8	308	16	effective	effective	JJ
cord-011917-6u0t4hy8	308	17	influenza	influenza	NN
cord-011917-6u0t4hy8	308	18	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	308	19	?	?	.
cord-011917-6u0t4hy8	309	1	Hum	Hum	NNP
cord-011917-6u0t4hy8	309	2	Effect	effect	NN
cord-011917-6u0t4hy8	309	3	of	of	IN
cord-011917-6u0t4hy8	309	4	Priming	prime	VBG
cord-011917-6u0t4hy8	309	5	With	with	IN
cord-011917-6u0t4hy8	309	6	Seasonal	Seasonal	NNP
cord-011917-6u0t4hy8	309	7	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	309	8	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	309	9	)	)	-RRB-
cord-011917-6u0t4hy8	310	1	Virus	virus	NN
cord-011917-6u0t4hy8	310	2	on	on	IN
cord-011917-6u0t4hy8	310	3	the	the	DT
cord-011917-6u0t4hy8	310	4	Prevalence	prevalence	NN
cord-011917-6u0t4hy8	310	5	of	of	IN
cord-011917-6u0t4hy8	310	6	Cross	Cross	NNP
cord-011917-6u0t4hy8	310	7	-	-	HYPH
cord-011917-6u0t4hy8	310	8	Reactive	Reactive	NNP
cord-011917-6u0t4hy8	310	9	Hemagglutination	Hemagglutination	NNP
cord-011917-6u0t4hy8	310	10	-	-	HYPH
cord-011917-6u0t4hy8	310	11	Inhibition	Inhibition	NNP
cord-011917-6u0t4hy8	310	12	Antibodies	antibody	NNS
cord-011917-6u0t4hy8	310	13	to	to	IN
cord-011917-6u0t4hy8	310	14	Swine	Swine	NNP
cord-011917-6u0t4hy8	310	15	-	-	HYPH
cord-011917-6u0t4hy8	310	16	Origin	Origin	NNP
cord-011917-6u0t4hy8	310	17	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	310	18	)	)	-RRB-
cord-011917-6u0t4hy8	311	1	Variants	variant	NNS
cord-011917-6u0t4hy8	311	2	Potent	potent	JJ
cord-011917-6u0t4hy8	311	3	protection	protection	NN
cord-011917-6u0t4hy8	311	4	against	against	IN
cord-011917-6u0t4hy8	311	5	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	311	6	and	and	CC
cord-011917-6u0t4hy8	311	7	H7N9	H7N9	NNP
cord-011917-6u0t4hy8	311	8	influenza	influenza	NN
cord-011917-6u0t4hy8	311	9	via	via	IN
cord-011917-6u0t4hy8	311	10	childhood	childhood	NN
cord-011917-6u0t4hy8	311	11	hemagglutinin	hemagglutinin	NN
cord-011917-6u0t4hy8	311	12	imprinting	imprint	VBG
cord-011917-6u0t4hy8	311	13	Broad	Broad	NNP
cord-011917-6u0t4hy8	311	14	Hemagglutinin	Hemagglutinin	NNP
cord-011917-6u0t4hy8	311	15	-	-	HYPH
cord-011917-6u0t4hy8	311	16	Specific	specific	JJ
cord-011917-6u0t4hy8	311	17	Memory	memory	NN
cord-011917-6u0t4hy8	311	18	B	B	NNP
cord-011917-6u0t4hy8	311	19	Cell	cell	NN
cord-011917-6u0t4hy8	311	20	Expansion	expansion	NN
cord-011917-6u0t4hy8	311	21	by	by	IN
cord-011917-6u0t4hy8	311	22	Seasonal	Seasonal	NNP
cord-011917-6u0t4hy8	311	23	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	311	24	Virus	Virus	NNP
cord-011917-6u0t4hy8	311	25	Infection	infection	NN
cord-011917-6u0t4hy8	311	26	Reflects	reflect	VBZ
cord-011917-6u0t4hy8	311	27	Early	early	JJ
cord-011917-6u0t4hy8	311	28	-	-	HYPH
cord-011917-6u0t4hy8	311	29	Life	life	NN
cord-011917-6u0t4hy8	311	30	Imprinting	Imprinting	NNP
cord-011917-6u0t4hy8	311	31	and	and	CC
cord-011917-6u0t4hy8	311	32	Adaptation	Adaptation	NNP
cord-011917-6u0t4hy8	311	33	to	to	IN
cord-011917-6u0t4hy8	311	34	the	the	DT
cord-011917-6u0t4hy8	311	35	Infecting	Infecting	NNP
cord-011917-6u0t4hy8	311	36	Virus	Virus	NNP
cord-011917-6u0t4hy8	311	37	Genesis	Genesis	NNP
cord-011917-6u0t4hy8	311	38	and	and	CC
cord-011917-6u0t4hy8	311	39	pathogenesis	pathogenesis	NN
cord-011917-6u0t4hy8	311	40	of	of	IN
cord-011917-6u0t4hy8	311	41	the	the	DT
cord-011917-6u0t4hy8	311	42	1918	1918	CD
cord-011917-6u0t4hy8	311	43	pandemic	pandemic	NN
cord-011917-6u0t4hy8	311	44	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	311	45	influenza	influenza	NN
cord-011917-6u0t4hy8	311	46	A	a	DT
cord-011917-6u0t4hy8	311	47	virus	virus	NN
cord-011917-6u0t4hy8	311	48	Neutralizing	neutralize	VBG
cord-011917-6u0t4hy8	311	49	antibodies	antibody	NNS
cord-011917-6u0t4hy8	311	50	against	against	IN
cord-011917-6u0t4hy8	311	51	previously	previously	RB
cord-011917-6u0t4hy8	311	52	encountered	encounter	VBN
cord-011917-6u0t4hy8	311	53	influenza	influenza	NN
cord-011917-6u0t4hy8	311	54	virus	virus	NN
cord-011917-6u0t4hy8	311	55	strains	strain	NNS
cord-011917-6u0t4hy8	311	56	increase	increase	VBP
cord-011917-6u0t4hy8	311	57	over	over	IN
cord-011917-6u0t4hy8	311	58	time	time	NN
cord-011917-6u0t4hy8	311	59	:	:	:
cord-011917-6u0t4hy8	311	60	A	a	DT
cord-011917-6u0t4hy8	311	61	longitudinal	longitudinal	JJ
cord-011917-6u0t4hy8	311	62	analysis	analysis	NN
cord-011917-6u0t4hy8	311	63	Cross	Cross	NNP
cord-011917-6u0t4hy8	311	64	-	-	JJ
cord-011917-6u0t4hy8	311	65	reactive	reactive	JJ
cord-011917-6u0t4hy8	311	66	antibody	antibody	NN
cord-011917-6u0t4hy8	311	67	responses	response	NNS
cord-011917-6u0t4hy8	311	68	to	to	IN
cord-011917-6u0t4hy8	311	69	the	the	DT
cord-011917-6u0t4hy8	311	70	2009	2009	CD
cord-011917-6u0t4hy8	311	71	pandemic	pandemic	NN
cord-011917-6u0t4hy8	311	72	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	311	73	influenza	influenza	NN
cord-011917-6u0t4hy8	311	74	virus	virus	NN
cord-011917-6u0t4hy8	311	75	Evidence	evidence	NN
cord-011917-6u0t4hy8	311	76	for	for	IN
cord-011917-6u0t4hy8	311	77	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	311	78	seniority	seniority	NN
cord-011917-6u0t4hy8	311	79	in	in	IN
cord-011917-6u0t4hy8	311	80	influenza	influenza	NN
cord-011917-6u0t4hy8	311	81	A	a	NN
cord-011917-6u0t4hy8	311	82	(	(	-LRB-
cord-011917-6u0t4hy8	311	83	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	311	84	)	)	-RRB-
cord-011917-6u0t4hy8	311	85	antibody	antibody	NN
cord-011917-6u0t4hy8	311	86	responses	response	NNS
cord-011917-6u0t4hy8	311	87	in	in	IN
cord-011917-6u0t4hy8	311	88	southern	southern	JJ
cord-011917-6u0t4hy8	311	89	China	China	NNP
cord-011917-6u0t4hy8	311	90	Severe	severe	JJ
cord-011917-6u0t4hy8	311	91	pandemic	pandemic	NN
cord-011917-6u0t4hy8	311	92	2009	2009	CD
cord-011917-6u0t4hy8	311	93	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	311	94	influenza	influenza	NN
cord-011917-6u0t4hy8	311	95	disease	disease	NN
cord-011917-6u0t4hy8	311	96	due	due	JJ
cord-011917-6u0t4hy8	311	97	to	to	IN
cord-011917-6u0t4hy8	311	98	pathogenic	pathogenic	JJ
cord-011917-6u0t4hy8	311	99	immune	immune	JJ
cord-011917-6u0t4hy8	311	100	complexes	complex	NNS
cord-011917-6u0t4hy8	311	101	Animal	Animal	NNP
cord-011917-6u0t4hy8	311	102	Models	Models	NNPS
cord-011917-6u0t4hy8	311	103	for	for	IN
cord-011917-6u0t4hy8	311	104	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	311	105	Virus	Virus	NNP
cord-011917-6u0t4hy8	311	106	Pathogenesis	Pathogenesis	NNP
cord-011917-6u0t4hy8	311	107	and	and	CC
cord-011917-6u0t4hy8	311	108	Transmission	Transmission	NNP
cord-011917-6u0t4hy8	311	109	Ferret	Ferret	NNP
cord-011917-6u0t4hy8	311	110	models	model	NNS
cord-011917-6u0t4hy8	311	111	of	of	IN
cord-011917-6u0t4hy8	311	112	viral	viral	JJ
cord-011917-6u0t4hy8	311	113	pathogenesis	pathogenesis	NN
cord-011917-6u0t4hy8	312	1	The	the	DT
cord-011917-6u0t4hy8	312	2	ferret	ferret	NN
cord-011917-6u0t4hy8	312	3	:	:	:
cord-011917-6u0t4hy8	312	4	An	an	DT
cord-011917-6u0t4hy8	312	5	animal	animal	NN
cord-011917-6u0t4hy8	312	6	model	model	NN
cord-011917-6u0t4hy8	312	7	to	to	TO
cord-011917-6u0t4hy8	312	8	study	study	VB
cord-011917-6u0t4hy8	312	9	influenza	influenza	NN
cord-011917-6u0t4hy8	312	10	virus	virus	NN
cord-011917-6u0t4hy8	312	11	Decoding	decode	VBG
cord-011917-6u0t4hy8	312	12	the	the	DT
cord-011917-6u0t4hy8	312	13	distribution	distribution	NN
cord-011917-6u0t4hy8	312	14	of	of	IN
cord-011917-6u0t4hy8	312	15	glycan	glycan	NN
cord-011917-6u0t4hy8	312	16	receptors	receptor	NNS
cord-011917-6u0t4hy8	312	17	for	for	IN
cord-011917-6u0t4hy8	312	18	human	human	NN
cord-011917-6u0t4hy8	312	19	-	-	HYPH
cord-011917-6u0t4hy8	312	20	adapted	adapt	VBN
cord-011917-6u0t4hy8	312	21	influenza	influenza	NN
cord-011917-6u0t4hy8	312	22	A	a	DT
cord-011917-6u0t4hy8	312	23	viruses	virus	NNS
cord-011917-6u0t4hy8	312	24	in	in	IN
cord-011917-6u0t4hy8	312	25	ferret	ferret	JJ
cord-011917-6u0t4hy8	312	26	respiratory	respiratory	JJ
cord-011917-6u0t4hy8	312	27	tract	tract	NN
cord-011917-6u0t4hy8	312	28	Ferrets	ferret	NNS
cord-011917-6u0t4hy8	312	29	exclusively	exclusively	RB
cord-011917-6u0t4hy8	312	30	synthesize	synthesize	VBP
cord-011917-6u0t4hy8	312	31	Neu5Ac	Neu5Ac	NNP
cord-011917-6u0t4hy8	312	32	and	and	CC
cord-011917-6u0t4hy8	312	33	express	express	VBP
cord-011917-6u0t4hy8	312	34	naturally	naturally	RB
cord-011917-6u0t4hy8	312	35	humanized	humanize	VBN
cord-011917-6u0t4hy8	312	36	influenza	influenza	NN
cord-011917-6u0t4hy8	312	37	A	a	DT
cord-011917-6u0t4hy8	312	38	virus	virus	NN
cord-011917-6u0t4hy8	312	39	receptors	receptor	NNS
cord-011917-6u0t4hy8	312	40	Glycomic	glycomic	JJ
cord-011917-6u0t4hy8	312	41	characterization	characterization	NN
cord-011917-6u0t4hy8	312	42	of	of	IN
cord-011917-6u0t4hy8	312	43	respiratory	respiratory	JJ
cord-011917-6u0t4hy8	312	44	tract	tract	NN
cord-011917-6u0t4hy8	312	45	tissues	tissue	NNS
cord-011917-6u0t4hy8	312	46	of	of	IN
cord-011917-6u0t4hy8	312	47	ferrets	ferret	NNS
cord-011917-6u0t4hy8	312	48	:	:	:
cord-011917-6u0t4hy8	313	1	Implications	implication	NNS
cord-011917-6u0t4hy8	313	2	for	for	IN
cord-011917-6u0t4hy8	313	3	its	-PRON-	PRP$
cord-011917-6u0t4hy8	313	4	use	use	NN
cord-011917-6u0t4hy8	313	5	in	in	IN
cord-011917-6u0t4hy8	313	6	influenza	influenza	NN
cord-011917-6u0t4hy8	313	7	virus	virus	NN
cord-011917-6u0t4hy8	313	8	infection	infection	NN
cord-011917-6u0t4hy8	313	9	studies	study	NNS
cord-011917-6u0t4hy8	314	1	Historical	historical	JJ
cord-011917-6u0t4hy8	314	2	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	314	3	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	314	4	Virus	Virus	NNP
cord-011917-6u0t4hy8	314	5	Imprinting	Imprinting	NNP
cord-011917-6u0t4hy8	314	6	Increases	increase	VBZ
cord-011917-6u0t4hy8	314	7	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	314	8	Protection	Protection	NNP
cord-011917-6u0t4hy8	314	9	by	by	IN
cord-011917-6u0t4hy8	314	10	Influencing	influence	VBG
cord-011917-6u0t4hy8	314	11	the	the	DT
cord-011917-6u0t4hy8	314	12	Activity	Activity	NNP
cord-011917-6u0t4hy8	314	13	and	and	CC
cord-011917-6u0t4hy8	314	14	Sustained	Sustained	NNP
cord-011917-6u0t4hy8	314	15	Production	Production	NNP
cord-011917-6u0t4hy8	314	16	of	of	IN
cord-011917-6u0t4hy8	314	17	Antibodies	Antibodies	NNP
cord-011917-6u0t4hy8	314	18	Elicited	elicit	VBN
cord-011917-6u0t4hy8	314	19	at	at	IN
cord-011917-6u0t4hy8	314	20	Vaccination	vaccination	NN
cord-011917-6u0t4hy8	314	21	in	in	IN
cord-011917-6u0t4hy8	314	22	Ferrets	Ferrets	NNPS
cord-011917-6u0t4hy8	314	23	.	.	.
cord-011917-6u0t4hy8	315	1	Vaccines	vaccine	NNS
cord-011917-6u0t4hy8	315	2	(	(	-LRB-
cord-011917-6u0t4hy8	315	3	Basel	Basel	NNP
cord-011917-6u0t4hy8	315	4	)	)	-RRB-
cord-011917-6u0t4hy8	316	1	Original	original	JJ
cord-011917-6u0t4hy8	316	2	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	316	3	sin	sin	NN
cord-011917-6u0t4hy8	316	4	:	:	:
cord-011917-6u0t4hy8	316	5	A	a	DT
cord-011917-6u0t4hy8	316	6	comprehensive	comprehensive	JJ
cord-011917-6u0t4hy8	316	7	review	review	NN
cord-011917-6u0t4hy8	316	8	Antigenic	antigenic	JJ
cord-011917-6u0t4hy8	316	9	Change	change	NN
cord-011917-6u0t4hy8	316	10	in	in	IN
cord-011917-6u0t4hy8	316	11	Human	Human	NNP
cord-011917-6u0t4hy8	316	12	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	316	13	A(H2N2	A(H2N2	NNP
cord-011917-6u0t4hy8	316	14	)	)	-RRB-
cord-011917-6u0t4hy8	317	1	Viruses	virus	NNS
cord-011917-6u0t4hy8	317	2	Detected	detect	VBN
cord-011917-6u0t4hy8	317	3	by	by	IN
cord-011917-6u0t4hy8	317	4	Using	use	VBG
cord-011917-6u0t4hy8	317	5	Human	Human	NNP
cord-011917-6u0t4hy8	317	6	Plasma	Plasma	NNP
cord-011917-6u0t4hy8	317	7	from	from	IN
cord-011917-6u0t4hy8	317	8	Aged	Aged	NNP
cord-011917-6u0t4hy8	317	9	and	and	CC
cord-011917-6u0t4hy8	317	10	Younger	young	JJR
cord-011917-6u0t4hy8	317	11	Adult	Adult	NNP
cord-011917-6u0t4hy8	317	12	Individuals	individual	NNS
cord-011917-6u0t4hy8	317	13	.	.	.
cord-011917-6u0t4hy8	318	1	Viruses	virus	NNS
cord-011917-6u0t4hy8	319	1	The	the	DT
cord-011917-6u0t4hy8	319	2	virtues	virtue	NNS
cord-011917-6u0t4hy8	319	3	of	of	IN
cord-011917-6u0t4hy8	319	4	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	319	5	sin	sin	NN
cord-011917-6u0t4hy8	319	6	:	:	:
cord-011917-6u0t4hy8	319	7	Consequences	consequence	NNS
cord-011917-6u0t4hy8	319	8	of	of	IN
cord-011917-6u0t4hy8	319	9	pandemic	pandemic	NN
cord-011917-6u0t4hy8	319	10	recycling	recycling	NN
cord-011917-6u0t4hy8	319	11	on	on	IN
cord-011917-6u0t4hy8	319	12	influenza	influenza	NN
cord-011917-6u0t4hy8	319	13	-	-	HYPH
cord-011917-6u0t4hy8	319	14	associated	associate	VBN
cord-011917-6u0t4hy8	319	15	mortality	mortality	NN
cord-011917-6u0t4hy8	319	16	Immunity	immunity	NN
cord-011917-6u0t4hy8	319	17	to	to	IN
cord-011917-6u0t4hy8	319	18	pre-1950	pre-1950	NNS
cord-011917-6u0t4hy8	319	19	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	319	20	influenza	influenza	NN
cord-011917-6u0t4hy8	319	21	viruses	virus	NNS
cord-011917-6u0t4hy8	319	22	confers	confer	VBZ
cord-011917-6u0t4hy8	319	23	cross	cross	NN
cord-011917-6u0t4hy8	319	24	-	-	NN
cord-011917-6u0t4hy8	319	25	protection	protection	NN
cord-011917-6u0t4hy8	319	26	against	against	IN
cord-011917-6u0t4hy8	319	27	the	the	DT
cord-011917-6u0t4hy8	319	28	pandemic	pandemic	NN
cord-011917-6u0t4hy8	319	29	swine	swine	NN
cord-011917-6u0t4hy8	319	30	-	-	HYPH
cord-011917-6u0t4hy8	319	31	origin	origin	NN
cord-011917-6u0t4hy8	319	32	2009	2009	CD
cord-011917-6u0t4hy8	319	33	A	A	NNP
cord-011917-6u0t4hy8	319	34	(	(	-LRB-
cord-011917-6u0t4hy8	319	35	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	319	36	)	)	-RRB-
cord-011917-6u0t4hy8	319	37	influenza	influenza	NN
cord-011917-6u0t4hy8	319	38	virus	virus	NN
cord-011917-6u0t4hy8	320	1	Novel	Novel	NNP
cord-011917-6u0t4hy8	320	2	Swine	Swine	NNP
cord-011917-6u0t4hy8	320	3	-	-	HYPH
cord-011917-6u0t4hy8	320	4	Origin	Origin	NNP
cord-011917-6u0t4hy8	320	5	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	320	6	A	A	NNP
cord-011917-6u0t4hy8	320	7	Virus	Virus	NNP
cord-011917-6u0t4hy8	320	8	Investigation	Investigation	NNP
cord-011917-6u0t4hy8	320	9	Team	Team	NNP
cord-011917-6u0t4hy8	320	10	Emergence	Emergence	NNP
cord-011917-6u0t4hy8	320	11	of	of	IN
cord-011917-6u0t4hy8	320	12	a	a	DT
cord-011917-6u0t4hy8	320	13	novel	novel	JJ
cord-011917-6u0t4hy8	320	14	swine	swine	NN
cord-011917-6u0t4hy8	320	15	-	-	HYPH
cord-011917-6u0t4hy8	320	16	origin	origin	NN
cord-011917-6u0t4hy8	320	17	influenza	influenza	NN
cord-011917-6u0t4hy8	320	18	A	A	NNP
cord-011917-6u0t4hy8	320	19	(	(	-LRB-
cord-011917-6u0t4hy8	320	20	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	320	21	)	)	-RRB-
cord-011917-6u0t4hy8	320	22	virus	virus	NN
cord-011917-6u0t4hy8	320	23	in	in	IN
cord-011917-6u0t4hy8	320	24	humans	human	NNS
cord-011917-6u0t4hy8	320	25	Serum	Serum	NNP
cord-011917-6u0t4hy8	320	26	cross	cross	JJ
cord-011917-6u0t4hy8	320	27	-	-	JJ
cord-011917-6u0t4hy8	320	28	reactive	reactive	JJ
cord-011917-6u0t4hy8	320	29	antibody	antibody	NN
cord-011917-6u0t4hy8	320	30	response	response	NN
cord-011917-6u0t4hy8	320	31	to	to	IN
cord-011917-6u0t4hy8	320	32	a	a	DT
cord-011917-6u0t4hy8	320	33	novel	novel	JJ
cord-011917-6u0t4hy8	320	34	influenza	influenza	NN
cord-011917-6u0t4hy8	320	35	A	a	NN
cord-011917-6u0t4hy8	320	36	(	(	-LRB-
cord-011917-6u0t4hy8	320	37	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	320	38	)	)	-RRB-
cord-011917-6u0t4hy8	320	39	virus	virus	NN
cord-011917-6u0t4hy8	320	40	after	after	IN
cord-011917-6u0t4hy8	320	41	vaccination	vaccination	NN
cord-011917-6u0t4hy8	320	42	with	with	IN
cord-011917-6u0t4hy8	320	43	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	320	44	influenza	influenza	NN
cord-011917-6u0t4hy8	320	45	vaccine	vaccine	NN
cord-011917-6u0t4hy8	320	46	Back	back	RB
cord-011917-6u0t4hy8	320	47	to	to	IN
cord-011917-6u0t4hy8	320	48	the	the	DT
cord-011917-6u0t4hy8	320	49	Future	Future	NNP
cord-011917-6u0t4hy8	320	50	for	for	IN
cord-011917-6u0t4hy8	320	51	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	320	52	Preimmunity	Preimmunity	NNP
cord-011917-6u0t4hy8	320	53	-	-	HYPH
cord-011917-6u0t4hy8	320	54	Looking	look	VBG
cord-011917-6u0t4hy8	320	55	Back	back	RB
cord-011917-6u0t4hy8	320	56	at	at	IN
cord-011917-6u0t4hy8	320	57	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	320	58	Virus	Virus	NNP
cord-011917-6u0t4hy8	320	59	History	history	NN
cord-011917-6u0t4hy8	320	60	to	to	TO
cord-011917-6u0t4hy8	320	61	Infer	infer	VB
cord-011917-6u0t4hy8	320	62	the	the	DT
cord-011917-6u0t4hy8	320	63	Outcome	outcome	NN
cord-011917-6u0t4hy8	320	64	of	of	IN
cord-011917-6u0t4hy8	320	65	Future	Future	NNP
cord-011917-6u0t4hy8	320	66	Infections	Infections	NNPS
cord-011917-6u0t4hy8	320	67	Impact	Impact	NNP
cord-011917-6u0t4hy8	320	68	of	of	IN
cord-011917-6u0t4hy8	320	69	prior	prior	JJ
cord-011917-6u0t4hy8	320	70	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	320	71	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	320	72	influenza	influenza	NN
cord-011917-6u0t4hy8	320	73	vaccination	vaccination	NN
cord-011917-6u0t4hy8	320	74	or	or	CC
cord-011917-6u0t4hy8	320	75	infection	infection	NN
cord-011917-6u0t4hy8	320	76	on	on	IN
cord-011917-6u0t4hy8	320	77	protection	protection	NN
cord-011917-6u0t4hy8	320	78	and	and	CC
cord-011917-6u0t4hy8	320	79	transmission	transmission	NN
cord-011917-6u0t4hy8	320	80	of	of	IN
cord-011917-6u0t4hy8	320	81	emerging	emerge	VBG
cord-011917-6u0t4hy8	320	82	variants	variant	NNS
cord-011917-6u0t4hy8	320	83	of	of	IN
cord-011917-6u0t4hy8	320	84	influenza	influenza	NN
cord-011917-6u0t4hy8	320	85	A(H3N2)v	A(H3N2)v	,
cord-011917-6u0t4hy8	320	86	virus	virus	NN
cord-011917-6u0t4hy8	320	87	in	in	IN
cord-011917-6u0t4hy8	320	88	ferrets	ferret	NNS
cord-011917-6u0t4hy8	320	89	Influence	influence	NN
cord-011917-6u0t4hy8	320	90	of	of	IN
cord-011917-6u0t4hy8	320	91	Immune	Immune	NNP
cord-011917-6u0t4hy8	320	92	Priming	Priming	NNP
cord-011917-6u0t4hy8	320	93	and	and	CC
cord-011917-6u0t4hy8	320	94	Egg	Egg	NNP
cord-011917-6u0t4hy8	320	95	Adaptation	Adaptation	NNP
cord-011917-6u0t4hy8	320	96	in	in	IN
cord-011917-6u0t4hy8	320	97	the	the	DT
cord-011917-6u0t4hy8	320	98	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	320	99	on	on	IN
cord-011917-6u0t4hy8	320	100	Antibody	Antibody	NNP
cord-011917-6u0t4hy8	320	101	Responses	response	NNS
cord-011917-6u0t4hy8	320	102	to	to	IN
cord-011917-6u0t4hy8	320	103	Circulating	circulate	VBG
cord-011917-6u0t4hy8	320	104	A(H1N1)pdm09	a(h1n1)pdm09	NN
cord-011917-6u0t4hy8	320	105	Viruses	virus	NNS
cord-011917-6u0t4hy8	321	1	After	after	IN
cord-011917-6u0t4hy8	321	2	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	321	3	Vaccination	Vaccination	NNP
cord-011917-6u0t4hy8	321	4	in	in	IN
cord-011917-6u0t4hy8	321	5	Adults	Adults	NNP
cord-011917-6u0t4hy8	321	6	Spread	Spread	NNP
cord-011917-6u0t4hy8	321	7	of	of	IN
cord-011917-6u0t4hy8	321	8	Antigenically	Antigenically	NNP
cord-011917-6u0t4hy8	321	9	Drifted	drift	VBN
cord-011917-6u0t4hy8	321	10	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	321	11	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	321	12	)	)	-RRB-
cord-011917-6u0t4hy8	322	1	Viruses	virus	NNS
cord-011917-6u0t4hy8	322	2	and	and	CC
cord-011917-6u0t4hy8	322	3	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	322	4	Effectiveness	Effectiveness	NNP
cord-011917-6u0t4hy8	322	5	in	in	IN
cord-011917-6u0t4hy8	322	6	the	the	DT
cord-011917-6u0t4hy8	322	7	United	United	NNP
cord-011917-6u0t4hy8	322	8	States	States	NNP
cord-011917-6u0t4hy8	322	9	During	during	IN
cord-011917-6u0t4hy8	322	10	the	the	DT
cord-011917-6u0t4hy8	322	11	2018	2018	CD
cord-011917-6u0t4hy8	322	12	-	-	SYM
cord-011917-6u0t4hy8	322	13	2019	2019	CD
cord-011917-6u0t4hy8	322	14	Season	season	NN
cord-011917-6u0t4hy8	322	15	Effects	effect	NNS
cord-011917-6u0t4hy8	322	16	of	of	IN
cord-011917-6u0t4hy8	322	17	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	322	18	Vaccination	Vaccination	NNP
cord-011917-6u0t4hy8	322	19	in	in	IN
cord-011917-6u0t4hy8	322	20	the	the	DT
cord-011917-6u0t4hy8	322	21	United	United	NNP
cord-011917-6u0t4hy8	322	22	States	States	NNP
cord-011917-6u0t4hy8	322	23	During	during	IN
cord-011917-6u0t4hy8	322	24	the	the	DT
cord-011917-6u0t4hy8	322	25	2017	2017	CD
cord-011917-6u0t4hy8	322	26	-	-	SYM
cord-011917-6u0t4hy8	322	27	2018	2018	CD
cord-011917-6u0t4hy8	322	28	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	322	29	Season	Season	NNP
cord-011917-6u0t4hy8	322	30	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	322	31	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	322	32	Effectiveness	Effectiveness	NNP
cord-011917-6u0t4hy8	322	33	in	in	IN
cord-011917-6u0t4hy8	322	34	the	the	DT
cord-011917-6u0t4hy8	322	35	United	United	NNP
cord-011917-6u0t4hy8	322	36	States	States	NNP
cord-011917-6u0t4hy8	322	37	During	during	IN
cord-011917-6u0t4hy8	322	38	the	the	DT
cord-011917-6u0t4hy8	322	39	2016	2016	CD
cord-011917-6u0t4hy8	322	40	-	-	SYM
cord-011917-6u0t4hy8	322	41	2017	2017	CD
cord-011917-6u0t4hy8	322	42	Season	Season	NNP
cord-011917-6u0t4hy8	322	43	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	322	44	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	322	45	Effectiveness	Effectiveness	NNP
cord-011917-6u0t4hy8	322	46	in	in	IN
cord-011917-6u0t4hy8	322	47	the	the	DT
cord-011917-6u0t4hy8	322	48	United	United	NNP
cord-011917-6u0t4hy8	322	49	States	States	NNP
cord-011917-6u0t4hy8	322	50	by	by	IN
cord-011917-6u0t4hy8	322	51	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	322	52	Type	Type	NNP
cord-011917-6u0t4hy8	322	53	Efficacy	Efficacy	NNP
cord-011917-6u0t4hy8	322	54	and	and	CC
cord-011917-6u0t4hy8	322	55	safety	safety	NN
cord-011917-6u0t4hy8	322	56	of	of	IN
cord-011917-6u0t4hy8	322	57	high	high	JJ
cord-011917-6u0t4hy8	322	58	-	-	HYPH
cord-011917-6u0t4hy8	322	59	dose	dose	NN
cord-011917-6u0t4hy8	322	60	influenza	influenza	NN
cord-011917-6u0t4hy8	322	61	vaccine	vaccine	NN
cord-011917-6u0t4hy8	322	62	in	in	IN
cord-011917-6u0t4hy8	322	63	elderly	elderly	JJ
cord-011917-6u0t4hy8	322	64	adults	adult	NNS
cord-011917-6u0t4hy8	322	65	:	:	:
cord-011917-6u0t4hy8	323	1	A	a	DT
cord-011917-6u0t4hy8	323	2	systematic	systematic	JJ
cord-011917-6u0t4hy8	323	3	review	review	NN
cord-011917-6u0t4hy8	323	4	and	and	CC
cord-011917-6u0t4hy8	323	5	meta	meta	NNP
cord-011917-6u0t4hy8	323	6	-	-	HYPH
cord-011917-6u0t4hy8	323	7	analysis	analysis	NN
cord-011917-6u0t4hy8	324	1	The	the	DT
cord-011917-6u0t4hy8	324	2	ferret	ferret	NN
cord-011917-6u0t4hy8	324	3	as	as	IN
cord-011917-6u0t4hy8	324	4	a	a	DT
cord-011917-6u0t4hy8	324	5	model	model	NN
cord-011917-6u0t4hy8	324	6	organism	organism	NN
cord-011917-6u0t4hy8	324	7	to	to	TO
cord-011917-6u0t4hy8	324	8	study	study	VB
cord-011917-6u0t4hy8	324	9	influenza	influenza	NN
cord-011917-6u0t4hy8	324	10	A	a	DT
cord-011917-6u0t4hy8	324	11	virus	virus	NN
cord-011917-6u0t4hy8	324	12	infection	infection	NN
cord-011917-6u0t4hy8	324	13	Differential	differential	JJ
cord-011917-6u0t4hy8	324	14	pathological	pathological	JJ
cord-011917-6u0t4hy8	324	15	and	and	CC
cord-011917-6u0t4hy8	324	16	immune	immune	JJ
cord-011917-6u0t4hy8	324	17	responses	response	NNS
cord-011917-6u0t4hy8	324	18	in	in	IN
cord-011917-6u0t4hy8	324	19	newly	newly	RB
cord-011917-6u0t4hy8	324	20	weaned	wean	VBN
cord-011917-6u0t4hy8	324	21	ferrets	ferret	NNS
cord-011917-6u0t4hy8	324	22	are	be	VBP
cord-011917-6u0t4hy8	324	23	associated	associate	VBN
cord-011917-6u0t4hy8	324	24	with	with	IN
cord-011917-6u0t4hy8	324	25	a	a	DT
cord-011917-6u0t4hy8	324	26	mild	mild	JJ
cord-011917-6u0t4hy8	324	27	clinical	clinical	JJ
cord-011917-6u0t4hy8	324	28	outcome	outcome	NN
cord-011917-6u0t4hy8	324	29	of	of	IN
cord-011917-6u0t4hy8	324	30	pandemic	pandemic	NN
cord-011917-6u0t4hy8	324	31	2009	2009	CD
cord-011917-6u0t4hy8	324	32	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	324	33	infection	infection	NN
cord-011917-6u0t4hy8	325	1	Impaired	impair	VBN
cord-011917-6u0t4hy8	325	2	heterologous	heterologous	JJ
cord-011917-6u0t4hy8	325	3	immunity	immunity	NN
cord-011917-6u0t4hy8	325	4	in	in	IN
cord-011917-6u0t4hy8	325	5	aged	aged	JJ
cord-011917-6u0t4hy8	325	6	ferrets	ferret	NNS
cord-011917-6u0t4hy8	325	7	during	during	IN
cord-011917-6u0t4hy8	325	8	sequential	sequential	JJ
cord-011917-6u0t4hy8	325	9	influenza	influenza	NN
cord-011917-6u0t4hy8	325	10	A	a	DT
cord-011917-6u0t4hy8	325	11	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	325	12	infection	infection	NN
cord-011917-6u0t4hy8	325	13	Elicitation	Elicitation	NNP
cord-011917-6u0t4hy8	325	14	of	of	IN
cord-011917-6u0t4hy8	325	15	Protective	Protective	NNP
cord-011917-6u0t4hy8	325	16	Antibodies	Antibodies	NNPS
cord-011917-6u0t4hy8	325	17	against	against	IN
cord-011917-6u0t4hy8	325	18	20	20	CD
cord-011917-6u0t4hy8	325	19	Years	year	NNS
cord-011917-6u0t4hy8	325	20	of	of	IN
cord-011917-6u0t4hy8	325	21	Future	Future	NNP
cord-011917-6u0t4hy8	325	22	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	325	23	Cocirculating	Cocirculating	NNP
cord-011917-6u0t4hy8	325	24	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	325	25	Virus	Virus	NNP
cord-011917-6u0t4hy8	325	26	Variants	Variants	NNPS
cord-011917-6u0t4hy8	325	27	in	in	IN
cord-011917-6u0t4hy8	325	28	Ferrets	Ferrets	NNPS
cord-011917-6u0t4hy8	325	29	Preimmune	Preimmune	NNP
cord-011917-6u0t4hy8	325	30	to	to	IN
cord-011917-6u0t4hy8	325	31	Historical	historical	JJ
cord-011917-6u0t4hy8	325	32	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	325	33	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	325	34	Viruses	Viruses	NNPS
cord-011917-6u0t4hy8	325	35	Impact	Impact	NNP
cord-011917-6u0t4hy8	325	36	of	of	IN
cord-011917-6u0t4hy8	325	37	prior	prior	JJ
cord-011917-6u0t4hy8	325	38	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	325	39	influenza	influenza	NN
cord-011917-6u0t4hy8	325	40	vaccination	vaccination	NN
cord-011917-6u0t4hy8	325	41	and	and	CC
cord-011917-6u0t4hy8	325	42	infection	infection	NN
cord-011917-6u0t4hy8	325	43	on	on	IN
cord-011917-6u0t4hy8	325	44	pandemic	pandemic	NN
cord-011917-6u0t4hy8	325	45	A	a	NN
cord-011917-6u0t4hy8	325	46	(	(	-LRB-
cord-011917-6u0t4hy8	325	47	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	325	48	)	)	-RRB-
cord-011917-6u0t4hy8	325	49	influenza	influenza	NN
cord-011917-6u0t4hy8	325	50	virus	virus	NN
cord-011917-6u0t4hy8	325	51	replication	replication	NN
cord-011917-6u0t4hy8	325	52	in	in	IN
cord-011917-6u0t4hy8	325	53	ferrets	ferret	NNS
cord-011917-6u0t4hy8	325	54	Immunity	immunity	NN
cord-011917-6u0t4hy8	325	55	to	to	IN
cord-011917-6u0t4hy8	325	56	influenza	influenza	NN
cord-011917-6u0t4hy8	325	57	in	in	IN
cord-011917-6u0t4hy8	325	58	ferrets	ferret	NNS
cord-011917-6u0t4hy8	325	59	.	.	.
cord-011917-6u0t4hy8	326	1	VII	VII	NNP
cord-011917-6u0t4hy8	326	2	.	.	.
cord-011917-6u0t4hy8	327	1	Effect	effect	NN
cord-011917-6u0t4hy8	327	2	of	of	IN
cord-011917-6u0t4hy8	327	3	previous	previous	JJ
cord-011917-6u0t4hy8	327	4	infection	infection	NN
cord-011917-6u0t4hy8	327	5	with	with	IN
cord-011917-6u0t4hy8	327	6	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	327	7	and	and	CC
cord-011917-6u0t4hy8	327	8	heterologous	heterologous	NNP
cord-011917-6u0t4hy8	327	9	influenza	influenza	NN
cord-011917-6u0t4hy8	327	10	viruses	virus	NNS
cord-011917-6u0t4hy8	327	11	on	on	IN
cord-011917-6u0t4hy8	327	12	the	the	DT
cord-011917-6u0t4hy8	327	13	response	response	NN
cord-011917-6u0t4hy8	327	14	of	of	IN
cord-011917-6u0t4hy8	327	15	ferrets	ferret	NNS
cord-011917-6u0t4hy8	327	16	to	to	IN
cord-011917-6u0t4hy8	327	17	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	327	18	influenza	influenza	NN
cord-011917-6u0t4hy8	327	19	virus	virus	NN
cord-011917-6u0t4hy8	327	20	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	327	21	Evaluation	Evaluation	NNP
cord-011917-6u0t4hy8	327	22	of	of	IN
cord-011917-6u0t4hy8	327	23	trivalent	trivalent	JJ
cord-011917-6u0t4hy8	327	24	,	,	,
cord-011917-6u0t4hy8	327	25	live	live	JJ
cord-011917-6u0t4hy8	327	26	,	,	,
cord-011917-6u0t4hy8	327	27	cold	cold	RB
cord-011917-6u0t4hy8	327	28	-	-	HYPH
cord-011917-6u0t4hy8	327	29	adapted	adapt	VBN
cord-011917-6u0t4hy8	327	30	(	(	-LRB-
cord-011917-6u0t4hy8	327	31	CAIV	CAIV	NNP
cord-011917-6u0t4hy8	327	32	-	-	HYPH
cord-011917-6u0t4hy8	327	33	T	T	NNP
cord-011917-6u0t4hy8	327	34	)	)	-RRB-
cord-011917-6u0t4hy8	327	35	and	and	CC
cord-011917-6u0t4hy8	327	36	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	327	37	(	(	-LRB-
cord-011917-6u0t4hy8	327	38	TIV	TIV	NNP
cord-011917-6u0t4hy8	327	39	)	)	-RRB-
cord-011917-6u0t4hy8	327	40	influenza	influenza	NN
cord-011917-6u0t4hy8	327	41	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	327	42	in	in	IN
cord-011917-6u0t4hy8	327	43	prevention	prevention	NN
cord-011917-6u0t4hy8	327	44	of	of	IN
cord-011917-6u0t4hy8	327	45	virus	virus	NN
cord-011917-6u0t4hy8	327	46	infection	infection	NN
cord-011917-6u0t4hy8	327	47	and	and	CC
cord-011917-6u0t4hy8	327	48	illness	illness	NN
cord-011917-6u0t4hy8	327	49	following	follow	VBG
cord-011917-6u0t4hy8	327	50	challenge	challenge	NN
cord-011917-6u0t4hy8	327	51	of	of	IN
cord-011917-6u0t4hy8	327	52	adults	adult	NNS
cord-011917-6u0t4hy8	327	53	with	with	IN
cord-011917-6u0t4hy8	327	54	wild	wild	JJ
cord-011917-6u0t4hy8	327	55	-	-	HYPH
cord-011917-6u0t4hy8	327	56	type	type	NN
cord-011917-6u0t4hy8	327	57	influenza	influenza	NN
cord-011917-6u0t4hy8	327	58	A	a	NN
cord-011917-6u0t4hy8	327	59	(	(	-LRB-
cord-011917-6u0t4hy8	327	60	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	327	61	)	)	-RRB-
cord-011917-6u0t4hy8	327	62	,	,	,
cord-011917-6u0t4hy8	327	63	A	a	DT
cord-011917-6u0t4hy8	327	64	(	(	-LRB-
cord-011917-6u0t4hy8	327	65	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	327	66	)	)	-RRB-
cord-011917-6u0t4hy8	327	67	,	,	,
cord-011917-6u0t4hy8	327	68	and	and	CC
cord-011917-6u0t4hy8	327	69	B	b	NN
cord-011917-6u0t4hy8	327	70	viruses	virus	NNS
cord-011917-6u0t4hy8	327	71	.	.	.
cord-011917-6u0t4hy8	328	1	Vaccine	vaccine	NN
cord-011917-6u0t4hy8	328	2	Sterilizing	sterilize	VBG
cord-011917-6u0t4hy8	328	3	immunity	immunity	NN
cord-011917-6u0t4hy8	328	4	to	to	IN
cord-011917-6u0t4hy8	328	5	influenza	influenza	NN
cord-011917-6u0t4hy8	328	6	virus	virus	NN
cord-011917-6u0t4hy8	328	7	infection	infection	NN
cord-011917-6u0t4hy8	328	8	requires	require	VBZ
cord-011917-6u0t4hy8	328	9	local	local	JJ
cord-011917-6u0t4hy8	328	10	antigen	antigen	NN
cord-011917-6u0t4hy8	328	11	-	-	HYPH
cord-011917-6u0t4hy8	328	12	specific	specific	JJ
cord-011917-6u0t4hy8	328	13	T	T	NNP
cord-011917-6u0t4hy8	328	14	cell	cell	NN
cord-011917-6u0t4hy8	328	15	response	response	NN
cord-011917-6u0t4hy8	328	16	in	in	IN
cord-011917-6u0t4hy8	328	17	the	the	DT
cord-011917-6u0t4hy8	328	18	lungs	lung	NNS
cord-011917-6u0t4hy8	329	1	Repeated	repeat	VBN
cord-011917-6u0t4hy8	329	2	vaccination	vaccination	NN
cord-011917-6u0t4hy8	329	3	against	against	IN
cord-011917-6u0t4hy8	329	4	matched	match	VBN
cord-011917-6u0t4hy8	329	5	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	329	6	influenza	influenza	NN
cord-011917-6u0t4hy8	329	7	virus	virus	NN
cord-011917-6u0t4hy8	329	8	gives	give	VBZ
cord-011917-6u0t4hy8	329	9	less	less	JJR
cord-011917-6u0t4hy8	329	10	protection	protection	NN
cord-011917-6u0t4hy8	329	11	than	than	IN
cord-011917-6u0t4hy8	329	12	single	single	JJ
cord-011917-6u0t4hy8	329	13	vaccination	vaccination	NN
cord-011917-6u0t4hy8	329	14	in	in	IN
cord-011917-6u0t4hy8	329	15	ferrets	ferret	NNS
cord-011917-6u0t4hy8	329	16	Vaccination	vaccination	NN
cord-011917-6u0t4hy8	329	17	against	against	IN
cord-011917-6u0t4hy8	329	18	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	329	19	influenza	influenza	NN
cord-011917-6u0t4hy8	329	20	A	a	NN
cord-011917-6u0t4hy8	329	21	/	/	SYM
cord-011917-6u0t4hy8	329	22	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	329	23	virus	virus	NN
cord-011917-6u0t4hy8	329	24	reduces	reduce	VBZ
cord-011917-6u0t4hy8	329	25	the	the	DT
cord-011917-6u0t4hy8	329	26	induction	induction	NN
cord-011917-6u0t4hy8	329	27	of	of	IN
cord-011917-6u0t4hy8	329	28	heterosubtypic	heterosubtypic	JJ
cord-011917-6u0t4hy8	329	29	immunity	immunity	NN
cord-011917-6u0t4hy8	329	30	against	against	IN
cord-011917-6u0t4hy8	329	31	influenza	influenza	NN
cord-011917-6u0t4hy8	329	32	A	A	NNP
cord-011917-6u0t4hy8	329	33	/	/	SYM
cord-011917-6u0t4hy8	329	34	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	329	35	virus	virus	NN
cord-011917-6u0t4hy8	329	36	infection	infection	NN
cord-011917-6u0t4hy8	329	37	in	in	IN
cord-011917-6u0t4hy8	329	38	ferrets	ferret	NNS
cord-011917-6u0t4hy8	329	39	Evaluation	Evaluation	NNP
cord-011917-6u0t4hy8	329	40	of	of	IN
cord-011917-6u0t4hy8	329	41	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	329	42	for	for	IN
cord-011917-6u0t4hy8	329	43	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	329	44	influenza	influenza	NN
cord-011917-6u0t4hy8	329	45	virus	virus	NN
cord-011917-6u0t4hy8	329	46	in	in	IN
cord-011917-6u0t4hy8	329	47	ferrets	ferret	NNS
cord-011917-6u0t4hy8	329	48	reveals	reveal	VBZ
cord-011917-6u0t4hy8	329	49	the	the	DT
cord-011917-6u0t4hy8	329	50	potential	potential	NN
cord-011917-6u0t4hy8	329	51	for	for	IN
cord-011917-6u0t4hy8	329	52	protective	protective	JJ
cord-011917-6u0t4hy8	329	53	single	single	JJ
cord-011917-6u0t4hy8	329	54	-	-	HYPH
cord-011917-6u0t4hy8	329	55	shot	shot	NN
cord-011917-6u0t4hy8	329	56	immunization	immunization	NN
cord-011917-6u0t4hy8	329	57	Immunity	immunity	NN
cord-011917-6u0t4hy8	329	58	to	to	IN
cord-011917-6u0t4hy8	329	59	influenza	influenza	NN
cord-011917-6u0t4hy8	329	60	in	in	IN
cord-011917-6u0t4hy8	329	61	ferrets	ferret	NNS
cord-011917-6u0t4hy8	329	62	.	.	.
cord-011917-6u0t4hy8	330	1	V.	V.	NNP
cord-011917-6u0t4hy8	330	2	Immunization	Immunization	NNP
cord-011917-6u0t4hy8	330	3	with	with	IN
cord-011917-6u0t4hy8	330	4	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	330	5	virus	virus	NN
cord-011917-6u0t4hy8	330	6	in	in	IN
cord-011917-6u0t4hy8	330	7	adjuvant	adjuvant	NN
cord-011917-6u0t4hy8	330	8	65	65	CD
cord-011917-6u0t4hy8	330	9	Immunity	immunity	NN
cord-011917-6u0t4hy8	330	10	to	to	IN
cord-011917-6u0t4hy8	330	11	influenza	influenza	NN
cord-011917-6u0t4hy8	330	12	in	in	IN
cord-011917-6u0t4hy8	330	13	ferrets	ferret	NNS
cord-011917-6u0t4hy8	330	14	.	.	.
cord-011917-6u0t4hy8	331	1	I.	I.	NNP
cord-011917-6u0t4hy8	331	2	Response	response	NN
cord-011917-6u0t4hy8	331	3	to	to	TO
cord-011917-6u0t4hy8	331	4	live	live	VB
cord-011917-6u0t4hy8	331	5	and	and	CC
cord-011917-6u0t4hy8	331	6	killed	kill	VBD
cord-011917-6u0t4hy8	331	7	virus	virus	NN
cord-011917-6u0t4hy8	331	8	The	the	DT
cord-011917-6u0t4hy8	331	9	immune	immune	JJ
cord-011917-6u0t4hy8	331	10	correlates	correlate	NNS
cord-011917-6u0t4hy8	331	11	of	of	IN
cord-011917-6u0t4hy8	331	12	protection	protection	NN
cord-011917-6u0t4hy8	331	13	for	for	IN
cord-011917-6u0t4hy8	331	14	an	an	DT
cord-011917-6u0t4hy8	331	15	avian	avian	JJ
cord-011917-6u0t4hy8	331	16	influenza	influenza	NN
cord-011917-6u0t4hy8	331	17	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	331	18	vaccine	vaccine	NN
cord-011917-6u0t4hy8	331	19	in	in	IN
cord-011917-6u0t4hy8	331	20	the	the	DT
cord-011917-6u0t4hy8	331	21	ferret	ferret	NN
cord-011917-6u0t4hy8	331	22	model	model	NN
cord-011917-6u0t4hy8	331	23	using	use	VBG
cord-011917-6u0t4hy8	331	24	oil	oil	NN
cord-011917-6u0t4hy8	331	25	-	-	HYPH
cord-011917-6u0t4hy8	331	26	in	in	IN
cord-011917-6u0t4hy8	331	27	-	-	HYPH
cord-011917-6u0t4hy8	331	28	water	water	NN
cord-011917-6u0t4hy8	331	29	adjuvants	adjuvant	NNS
cord-011917-6u0t4hy8	331	30	Trial	Trial	NNP
cord-011917-6u0t4hy8	331	31	of	of	IN
cord-011917-6u0t4hy8	331	32	2009	2009	CD
cord-011917-6u0t4hy8	331	33	influenza	influenza	NN
cord-011917-6u0t4hy8	331	34	A	a	NN
cord-011917-6u0t4hy8	331	35	(	(	-LRB-
cord-011917-6u0t4hy8	331	36	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	331	37	)	)	-RRB-
cord-011917-6u0t4hy8	331	38	monovalent	monovalent	NNP
cord-011917-6u0t4hy8	331	39	MF59-adjuvanted	MF59-adjuvanted	NNP
cord-011917-6u0t4hy8	331	40	vaccine	vaccine	NN
cord-011917-6u0t4hy8	331	41	A	a	DT
cord-011917-6u0t4hy8	331	42	recombinant	recombinant	JJ
cord-011917-6u0t4hy8	331	43	viruslike	viruslike	JJ
cord-011917-6u0t4hy8	331	44	particle	particle	NN
cord-011917-6u0t4hy8	331	45	influenza	influenza	NN
cord-011917-6u0t4hy8	331	46	A	a	NN
cord-011917-6u0t4hy8	331	47	(	(	-LRB-
cord-011917-6u0t4hy8	331	48	H7N9	H7N9	NNP
cord-011917-6u0t4hy8	331	49	)	)	-RRB-
cord-011917-6u0t4hy8	331	50	vaccine	vaccine	NN
cord-011917-6u0t4hy8	332	1	A	a	DT
cord-011917-6u0t4hy8	332	2	cell	cell	NN
cord-011917-6u0t4hy8	332	3	culture	culture	NN
cord-011917-6u0t4hy8	332	4	-	-	HYPH
cord-011917-6u0t4hy8	332	5	derived	derive	VBN
cord-011917-6u0t4hy8	332	6	MF59-adjuvanted	MF59-adjuvanted	NNP
cord-011917-6u0t4hy8	332	7	pandemic	pandemic	NN
cord-011917-6u0t4hy8	332	8	A	A	NNP
cord-011917-6u0t4hy8	332	9	/	/	SYM
cord-011917-6u0t4hy8	332	10	H7N9	H7N9	NNP
cord-011917-6u0t4hy8	332	11	vaccine	vaccine	NN
cord-011917-6u0t4hy8	332	12	is	be	VBZ
cord-011917-6u0t4hy8	332	13	immunogenic	immunogenic	JJ
cord-011917-6u0t4hy8	332	14	in	in	IN
cord-011917-6u0t4hy8	332	15	adults	adult	NNS
cord-011917-6u0t4hy8	332	16	Safety	safety	NN
cord-011917-6u0t4hy8	332	17	and	and	CC
cord-011917-6u0t4hy8	332	18	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	332	19	of	of	IN
cord-011917-6u0t4hy8	332	20	2009	2009	CD
cord-011917-6u0t4hy8	332	21	pandemic	pandemic	NN
cord-011917-6u0t4hy8	333	1	influenza	influenza	NN
cord-011917-6u0t4hy8	333	2	A	a	DT
cord-011917-6u0t4hy8	333	3	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	333	4	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	333	5	in	in	IN
cord-011917-6u0t4hy8	333	6	China	China	NNP
cord-011917-6u0t4hy8	333	7	:	:	:
cord-011917-6u0t4hy8	333	8	A	a	DT
cord-011917-6u0t4hy8	333	9	multicentre	multicentre	NN
cord-011917-6u0t4hy8	333	10	,	,	,
cord-011917-6u0t4hy8	333	11	double	double	JJ
cord-011917-6u0t4hy8	333	12	-	-	HYPH
cord-011917-6u0t4hy8	333	13	blind	blind	JJ
cord-011917-6u0t4hy8	333	14	,	,	,
cord-011917-6u0t4hy8	333	15	randomised	randomised	JJ
cord-011917-6u0t4hy8	333	16	,	,	,
cord-011917-6u0t4hy8	333	17	placebo	placebo	NN
cord-011917-6u0t4hy8	333	18	-	-	HYPH
cord-011917-6u0t4hy8	333	19	controlled	control	VBN
cord-011917-6u0t4hy8	333	20	trial	trial	NN
cord-011917-6u0t4hy8	333	21	Safety	safety	NN
cord-011917-6u0t4hy8	333	22	and	and	CC
cord-011917-6u0t4hy8	333	23	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	333	24	of	of	IN
cord-011917-6u0t4hy8	333	25	influenza	influenza	NN
cord-011917-6u0t4hy8	333	26	A	a	DT
cord-011917-6u0t4hy8	333	27	H5	H5	NNP
cord-011917-6u0t4hy8	333	28	subunit	subunit	NN
cord-011917-6u0t4hy8	333	29	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	333	30	:	:	:
cord-011917-6u0t4hy8	333	31	Effect	effect	NN
cord-011917-6u0t4hy8	333	32	of	of	IN
cord-011917-6u0t4hy8	333	33	vaccine	vaccine	NN
cord-011917-6u0t4hy8	333	34	schedule	schedule	NN
cord-011917-6u0t4hy8	333	35	and	and	CC
cord-011917-6u0t4hy8	333	36	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	333	37	variant	variant	NN
cord-011917-6u0t4hy8	333	38	Safety	safety	NN
cord-011917-6u0t4hy8	333	39	and	and	CC
cord-011917-6u0t4hy8	333	40	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	333	41	of	of	IN
cord-011917-6u0t4hy8	333	42	a	a	DT
cord-011917-6u0t4hy8	333	43	recombinant	recombinant	JJ
cord-011917-6u0t4hy8	333	44	hemagglutinin	hemagglutinin	NN
cord-011917-6u0t4hy8	333	45	vaccine	vaccine	NN
cord-011917-6u0t4hy8	333	46	for	for	IN
cord-011917-6u0t4hy8	333	47	H5	H5	NNP
cord-011917-6u0t4hy8	333	48	influenza	influenza	NN
cord-011917-6u0t4hy8	333	49	in	in	IN
cord-011917-6u0t4hy8	333	50	humans	human	NNS
cord-011917-6u0t4hy8	333	51	Safety	Safety	NNP
cord-011917-6u0t4hy8	333	52	and	and	CC
cord-011917-6u0t4hy8	333	53	immunogenicity	immunogenicity	NN
cord-011917-6u0t4hy8	333	54	of	of	IN
cord-011917-6u0t4hy8	333	55	an	an	DT
cord-011917-6u0t4hy8	333	56	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	333	57	subvirion	subvirion	NN
cord-011917-6u0t4hy8	333	58	influenza	influenza	NN
cord-011917-6u0t4hy8	333	59	A	a	NN
cord-011917-6u0t4hy8	333	60	(	(	-LRB-
cord-011917-6u0t4hy8	333	61	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	333	62	)	)	-RRB-
cord-011917-6u0t4hy8	333	63	vaccine	vaccine	NN
cord-011917-6u0t4hy8	333	64	Carbohydrate	carbohydrate	NN
cord-011917-6u0t4hy8	333	65	fatty	fatty	JJ
cord-011917-6u0t4hy8	333	66	acid	acid	NN
cord-011917-6u0t4hy8	333	67	monosulphate	monosulphate	NN
cord-011917-6u0t4hy8	333	68	esters	ester	NNS
cord-011917-6u0t4hy8	333	69	are	be	VBP
cord-011917-6u0t4hy8	333	70	safe	safe	JJ
cord-011917-6u0t4hy8	333	71	and	and	CC
cord-011917-6u0t4hy8	333	72	effective	effective	JJ
cord-011917-6u0t4hy8	333	73	adjuvants	adjuvant	NNS
cord-011917-6u0t4hy8	333	74	for	for	IN
cord-011917-6u0t4hy8	333	75	humoral	humoral	JJ
cord-011917-6u0t4hy8	333	76	responses	response	NNS
cord-011917-6u0t4hy8	334	1	Influenza	influenza	NN
cord-011917-6u0t4hy8	334	2	virus	virus	NN
cord-011917-6u0t4hy8	334	3	-	-	HYPH
cord-011917-6u0t4hy8	334	4	like	like	JJ
cord-011917-6u0t4hy8	334	5	particles	particle	NNS
cord-011917-6u0t4hy8	334	6	elicit	elicit	VBP
cord-011917-6u0t4hy8	334	7	broader	broad	JJR
cord-011917-6u0t4hy8	334	8	immune	immune	JJ
cord-011917-6u0t4hy8	334	9	responses	response	NNS
cord-011917-6u0t4hy8	334	10	than	than	IN
cord-011917-6u0t4hy8	334	11	whole	whole	JJ
cord-011917-6u0t4hy8	334	12	virion	virion	NN
cord-011917-6u0t4hy8	334	13	inactivated	inactivate	VBD
cord-011917-6u0t4hy8	334	14	influenza	influenza	NN
cord-011917-6u0t4hy8	334	15	virus	virus	NN
cord-011917-6u0t4hy8	334	16	or	or	CC
cord-011917-6u0t4hy8	334	17	recombinant	recombinant	JJ
cord-011917-6u0t4hy8	334	18	hemagglutinin	hemagglutinin	NN
cord-011917-6u0t4hy8	334	19	Neuraminidase	neuraminidase	NN
cord-011917-6u0t4hy8	334	20	-	-	HYPH
cord-011917-6u0t4hy8	334	21	based	base	VBN
cord-011917-6u0t4hy8	334	22	recombinant	recombinant	JJ
cord-011917-6u0t4hy8	334	23	virus	virus	NN
cord-011917-6u0t4hy8	334	24	-	-	HYPH
cord-011917-6u0t4hy8	334	25	like	like	JJ
cord-011917-6u0t4hy8	334	26	particles	particle	NNS
cord-011917-6u0t4hy8	334	27	protect	protect	VBP
cord-011917-6u0t4hy8	334	28	against	against	IN
cord-011917-6u0t4hy8	334	29	lethal	lethal	JJ
cord-011917-6u0t4hy8	334	30	avian	avian	JJ
cord-011917-6u0t4hy8	334	31	influenza	influenza	NN
cord-011917-6u0t4hy8	334	32	A(H5N1	A(H5N1	NNP
cord-011917-6u0t4hy8	334	33	)	)	-RRB-
cord-011917-6u0t4hy8	334	34	virus	virus	NN
cord-011917-6u0t4hy8	334	35	infection	infection	NN
cord-011917-6u0t4hy8	334	36	in	in	IN
cord-011917-6u0t4hy8	334	37	ferrets	ferret	NNS
cord-011917-6u0t4hy8	334	38	Preclinical	preclinical	JJ
cord-011917-6u0t4hy8	334	39	evaluation	evaluation	NN
cord-011917-6u0t4hy8	334	40	of	of	IN
cord-011917-6u0t4hy8	334	41	the	the	DT
cord-011917-6u0t4hy8	334	42	efficacy	efficacy	NN
cord-011917-6u0t4hy8	334	43	of	of	IN
cord-011917-6u0t4hy8	334	44	an	an	DT
cord-011917-6u0t4hy8	334	45	H5N8	H5N8	NNP
cord-011917-6u0t4hy8	334	46	vaccine	vaccine	NN
cord-011917-6u0t4hy8	334	47	candidate	candidate	NN
cord-011917-6u0t4hy8	334	48	(	(	-LRB-
cord-011917-6u0t4hy8	334	49	IDCDC	IDCDC	NNP
cord-011917-6u0t4hy8	334	50	-	-	HYPH
cord-011917-6u0t4hy8	334	51	RG43A	RG43A	NNP
cord-011917-6u0t4hy8	334	52	)	)	-RRB-
cord-011917-6u0t4hy8	334	53	in	in	IN
cord-011917-6u0t4hy8	334	54	mouse	mouse	NN
cord-011917-6u0t4hy8	334	55	and	and	CC
cord-011917-6u0t4hy8	334	56	ferret	ferret	NN
cord-011917-6u0t4hy8	334	57	models	model	NNS
cord-011917-6u0t4hy8	334	58	for	for	IN
cord-011917-6u0t4hy8	334	59	pandemic	pandemic	NN
cord-011917-6u0t4hy8	334	60	preparedness	preparedness	NN
cord-011917-6u0t4hy8	334	61	Elicitation	Elicitation	NNP
cord-011917-6u0t4hy8	334	62	of	of	IN
cord-011917-6u0t4hy8	334	63	Protective	Protective	NNP
cord-011917-6u0t4hy8	334	64	Antibodies	Antibodies	NNPS
cord-011917-6u0t4hy8	334	65	against	against	IN
cord-011917-6u0t4hy8	334	66	a	a	DT
cord-011917-6u0t4hy8	334	67	Broad	Broad	NNP
cord-011917-6u0t4hy8	334	68	Panel	Panel	NNP
cord-011917-6u0t4hy8	334	69	of	of	IN
cord-011917-6u0t4hy8	334	70	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	334	71	Viruses	Viruses	NNPS
cord-011917-6u0t4hy8	334	72	in	in	IN
cord-011917-6u0t4hy8	334	73	Ferrets	Ferrets	NNPS
cord-011917-6u0t4hy8	334	74	Preimmune	Preimmune	NNP
cord-011917-6u0t4hy8	334	75	to	to	IN
cord-011917-6u0t4hy8	334	76	Historical	Historical	NNP
cord-011917-6u0t4hy8	334	77	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	335	1	Influenza	influenza	NN
cord-011917-6u0t4hy8	335	2	Viruses	Viruses	NNPS
cord-011917-6u0t4hy8	335	3	Effect	Effect	NNP
cord-011917-6u0t4hy8	335	4	of	of	IN
cord-011917-6u0t4hy8	335	5	priming	prime	VBG
cord-011917-6u0t4hy8	335	6	infection	infection	NN
cord-011917-6u0t4hy8	335	7	on	on	IN
cord-011917-6u0t4hy8	335	8	serologic	serologic	JJ
cord-011917-6u0t4hy8	335	9	response	response	NN
cord-011917-6u0t4hy8	335	10	to	to	IN
cord-011917-6u0t4hy8	335	11	whole	whole	NN
cord-011917-6u0t4hy8	335	12	and	and	CC
cord-011917-6u0t4hy8	335	13	subunit	subunit	NN
cord-011917-6u0t4hy8	335	14	influenza	influenza	NN
cord-011917-6u0t4hy8	335	15	virus	virus	NN
cord-011917-6u0t4hy8	335	16	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	335	17	in	in	IN
cord-011917-6u0t4hy8	335	18	animals	animal	NNS
cord-011917-6u0t4hy8	336	1	Enhanced	enhanced	JJ
cord-011917-6u0t4hy8	336	2	response	response	NN
cord-011917-6u0t4hy8	336	3	to	to	IN
cord-011917-6u0t4hy8	336	4	influenza	influenza	VB
cord-011917-6u0t4hy8	336	5	A	a	DT
cord-011917-6u0t4hy8	336	6	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	336	7	in	in	IN
cord-011917-6u0t4hy8	336	8	hamsters	hamster	NNS
cord-011917-6u0t4hy8	336	9	primed	prime	VBN
cord-011917-6u0t4hy8	336	10	by	by	IN
cord-011917-6u0t4hy8	336	11	prior	prior	JJ
cord-011917-6u0t4hy8	336	12	heterotype	heterotype	NN
cord-011917-6u0t4hy8	336	13	influenza	influenza	NN
cord-011917-6u0t4hy8	336	14	infection	infection	NN
cord-011917-6u0t4hy8	336	15	Potentiation	Potentiation	NNP
cord-011917-6u0t4hy8	336	16	of	of	IN
cord-011917-6u0t4hy8	336	17	the	the	DT
cord-011917-6u0t4hy8	336	18	antibody	antibody	NN
cord-011917-6u0t4hy8	336	19	response	response	NN
cord-011917-6u0t4hy8	336	20	to	to	IN
cord-011917-6u0t4hy8	336	21	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	336	22	A2-Hong	a2-hong	IN
cord-011917-6u0t4hy8	336	23	Kong	Kong	NNP
cord-011917-6u0t4hy8	336	24	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	336	25	by	by	IN
cord-011917-6u0t4hy8	336	26	previous	previous	JJ
cord-011917-6u0t4hy8	336	27	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	336	28	influenza	influenza	NNP
cord-011917-6u0t4hy8	336	29	virus	virus	NN
cord-011917-6u0t4hy8	336	30	infection	infection	NN
cord-011917-6u0t4hy8	336	31	Original	original	JJ
cord-011917-6u0t4hy8	336	32	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	336	33	sin	sin	NN
cord-011917-6u0t4hy8	336	34	in	in	IN
cord-011917-6u0t4hy8	336	35	ferrets	ferret	NNS
cord-011917-6u0t4hy8	336	36	:	:	:
cord-011917-6u0t4hy8	337	1	The	the	DT
cord-011917-6u0t4hy8	337	2	response	response	NN
cord-011917-6u0t4hy8	337	3	to	to	IN
cord-011917-6u0t4hy8	337	4	sequential	sequential	JJ
cord-011917-6u0t4hy8	337	5	infections	infection	NNS
cord-011917-6u0t4hy8	337	6	with	with	IN
cord-011917-6u0t4hy8	337	7	influenza	influenza	NN
cord-011917-6u0t4hy8	337	8	viruses	virus	NNS
cord-011917-6u0t4hy8	337	9	Immunity	immunity	NN
cord-011917-6u0t4hy8	337	10	to	to	IN
cord-011917-6u0t4hy8	337	11	influenza	influenza	NN
cord-011917-6u0t4hy8	337	12	in	in	IN
cord-011917-6u0t4hy8	337	13	ferrets	ferret	NNS
cord-011917-6u0t4hy8	337	14	.	.	.
cord-011917-6u0t4hy8	338	1	II	II	NNP
cord-011917-6u0t4hy8	338	2	.	.	.
cord-011917-6u0t4hy8	339	1	Influence	influence	NN
cord-011917-6u0t4hy8	339	2	of	of	IN
cord-011917-6u0t4hy8	339	3	adjuvants	adjuvant	NNS
cord-011917-6u0t4hy8	339	4	on	on	IN
cord-011917-6u0t4hy8	339	5	immunization	immunization	NN
cord-011917-6u0t4hy8	339	6	Immunity	immunity	NN
cord-011917-6u0t4hy8	339	7	to	to	IN
cord-011917-6u0t4hy8	339	8	influenza	influenza	NN
cord-011917-6u0t4hy8	339	9	in	in	IN
cord-011917-6u0t4hy8	339	10	ferrets	ferret	NNS
cord-011917-6u0t4hy8	339	11	.	.	.
cord-011917-6u0t4hy8	340	1	8	8	CD
cord-011917-6u0t4hy8	340	2	.	.	.
cord-011917-6u0t4hy8	341	1	Serological	serological	JJ
cord-011917-6u0t4hy8	341	2	response	response	NN
cord-011917-6u0t4hy8	341	3	of	of	IN
cord-011917-6u0t4hy8	341	4	ferrets	ferret	NNS
cord-011917-6u0t4hy8	341	5	to	to	IN
cord-011917-6u0t4hy8	341	6	influenza	influenza	NN
cord-011917-6u0t4hy8	341	7	virus	virus	NN
cord-011917-6u0t4hy8	341	8	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	341	9	after	after	IN
cord-011917-6u0t4hy8	341	10	infection	infection	NN
cord-011917-6u0t4hy8	341	11	with	with	IN
cord-011917-6u0t4hy8	341	12	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	341	13	strains	strain	NNS
cord-011917-6u0t4hy8	341	14	of	of	IN
cord-011917-6u0t4hy8	341	15	influenza	influenza	NN
cord-011917-6u0t4hy8	341	16	Immunity	immunity	NN
cord-011917-6u0t4hy8	341	17	to	to	IN
cord-011917-6u0t4hy8	341	18	influenza	influenza	NN
cord-011917-6u0t4hy8	341	19	in	in	IN
cord-011917-6u0t4hy8	341	20	ferrets	ferret	NNS
cord-011917-6u0t4hy8	341	21	.	.	.
cord-011917-6u0t4hy8	342	1	X.	X.	NNP
cord-011917-6u0t4hy8	342	2	Intranasal	Intranasal	NNP
cord-011917-6u0t4hy8	342	3	immunization	immunization	NN
cord-011917-6u0t4hy8	342	4	of	of	IN
cord-011917-6u0t4hy8	342	5	ferrets	ferret	NNS
cord-011917-6u0t4hy8	342	6	with	with	IN
cord-011917-6u0t4hy8	342	7	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	342	8	influenza	influenza	NN
cord-011917-6u0t4hy8	342	9	A	a	DT
cord-011917-6u0t4hy8	342	10	virus	virus	NN
cord-011917-6u0t4hy8	342	11	vaccines	vaccine	VBZ
cord-011917-6u0t4hy8	342	12	Protection	Protection	NNP
cord-011917-6u0t4hy8	342	13	against	against	IN
cord-011917-6u0t4hy8	342	14	influenza	influenza	NN
cord-011917-6u0t4hy8	342	15	infection	infection	NN
cord-011917-6u0t4hy8	342	16	by	by	IN
cord-011917-6u0t4hy8	342	17	serum	serum	NN
cord-011917-6u0t4hy8	342	18	antibody	antibody	NN
cord-011917-6u0t4hy8	342	19	to	to	IN
cord-011917-6u0t4hy8	342	20	homologous	homologous	JJ
cord-011917-6u0t4hy8	342	21	haemagglutinin	haemagglutinin	NNS
cord-011917-6u0t4hy8	342	22	or	or	CC
cord-011917-6u0t4hy8	342	23	neuraminidase	neuraminidase	NN
cord-011917-6u0t4hy8	342	24	antigens	antigen	VBZ
cord-011917-6u0t4hy8	342	25	Heterotypic	Heterotypic	NNP
cord-011917-6u0t4hy8	342	26	immunity	immunity	NN
cord-011917-6u0t4hy8	342	27	to	to	IN
cord-011917-6u0t4hy8	342	28	influenza	influenza	NN
cord-011917-6u0t4hy8	342	29	in	in	IN
cord-011917-6u0t4hy8	342	30	ferrets	ferret	NNS
cord-011917-6u0t4hy8	343	1	In	in	IN
cord-011917-6u0t4hy8	343	2	vitro	vitro	FW
cord-011917-6u0t4hy8	343	3	and	and	CC
cord-011917-6u0t4hy8	343	4	in	in	IN
cord-011917-6u0t4hy8	343	5	vivo	vivo	NN
cord-011917-6u0t4hy8	343	6	characterization	characterization	NN
cord-011917-6u0t4hy8	343	7	of	of	IN
cord-011917-6u0t4hy8	343	8	new	new	JJ
cord-011917-6u0t4hy8	343	9	swine	swine	NN
cord-011917-6u0t4hy8	343	10	-	-	HYPH
cord-011917-6u0t4hy8	343	11	origin	origin	NN
cord-011917-6u0t4hy8	343	12	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	343	13	influenza	influenza	NN
cord-011917-6u0t4hy8	343	14	viruses	viruse	VBZ
cord-011917-6u0t4hy8	343	15	Multiple	multiple	JJ
cord-011917-6u0t4hy8	343	16	infections	infection	NNS
cord-011917-6u0t4hy8	343	17	with	with	IN
cord-011917-6u0t4hy8	343	18	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	343	19	influenza	influenza	NN
cord-011917-6u0t4hy8	343	20	A	a	DT
cord-011917-6u0t4hy8	343	21	virus	virus	NN
cord-011917-6u0t4hy8	343	22	induce	induce	VB
cord-011917-6u0t4hy8	343	23	cross	cross	JJ
cord-011917-6u0t4hy8	343	24	-	-	JJ
cord-011917-6u0t4hy8	343	25	protective	protective	JJ
cord-011917-6u0t4hy8	343	26	immunity	immunity	NN
cord-011917-6u0t4hy8	343	27	against	against	IN
cord-011917-6u0t4hy8	343	28	A(H1N1	A(H1N1	NNP
cord-011917-6u0t4hy8	343	29	)	)	-RRB-
cord-011917-6u0t4hy8	344	1	pandemic	pandemic	NNP
cord-011917-6u0t4hy8	344	2	influenza	influenza	NN
cord-011917-6u0t4hy8	344	3	virus	virus	NN
cord-011917-6u0t4hy8	344	4	in	in	IN
cord-011917-6u0t4hy8	344	5	a	a	DT
cord-011917-6u0t4hy8	344	6	ferret	ferret	JJ
cord-011917-6u0t4hy8	344	7	model	model	NN
cord-011917-6u0t4hy8	344	8	Effect	effect	NN
cord-011917-6u0t4hy8	344	9	of	of	IN
cord-011917-6u0t4hy8	344	10	priming	prime	VBG
cord-011917-6u0t4hy8	344	11	with	with	IN
cord-011917-6u0t4hy8	344	12	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	344	13	influenza	influenza	NN
cord-011917-6u0t4hy8	344	14	viruses	virus	NNS
cord-011917-6u0t4hy8	344	15	of	of	IN
cord-011917-6u0t4hy8	344	16	variable	variable	JJ
cord-011917-6u0t4hy8	344	17	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	344	18	distances	distance	NNS
cord-011917-6u0t4hy8	344	19	on	on	IN
cord-011917-6u0t4hy8	344	20	challenge	challenge	NN
cord-011917-6u0t4hy8	344	21	with	with	IN
cord-011917-6u0t4hy8	344	22	2009	2009	CD
cord-011917-6u0t4hy8	344	23	pandemic	pandemic	NN
cord-011917-6u0t4hy8	344	24	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	344	25	virus	virus	NN
cord-011917-6u0t4hy8	344	26	Efficacy	Efficacy	NNP
cord-011917-6u0t4hy8	344	27	of	of	IN
cord-011917-6u0t4hy8	344	28	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	344	29	live	live	JJ
cord-011917-6u0t4hy8	344	30	attenuated	attenuated	JJ
cord-011917-6u0t4hy8	344	31	influenza	influenza	NN
cord-011917-6u0t4hy8	344	32	vaccine	vaccine	NN
cord-011917-6u0t4hy8	344	33	against	against	IN
cord-011917-6u0t4hy8	344	34	virus	virus	NN
cord-011917-6u0t4hy8	344	35	replication	replication	NN
cord-011917-6u0t4hy8	344	36	and	and	CC
cord-011917-6u0t4hy8	344	37	transmission	transmission	NN
cord-011917-6u0t4hy8	344	38	of	of	IN
cord-011917-6u0t4hy8	344	39	a	a	DT
cord-011917-6u0t4hy8	344	40	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	344	41	2009	2009	CD
cord-011917-6u0t4hy8	344	42	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	344	43	virus	virus	NN
cord-011917-6u0t4hy8	344	44	in	in	IN
cord-011917-6u0t4hy8	344	45	ferrets	ferret	NNS
cord-011917-6u0t4hy8	345	1	Sequential	sequential	JJ
cord-011917-6u0t4hy8	345	2	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	345	3	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	345	4	influenza	influenza	NN
cord-011917-6u0t4hy8	345	5	virus	virus	NN
cord-011917-6u0t4hy8	345	6	infections	infection	NNS
cord-011917-6u0t4hy8	345	7	protect	protect	VBP
cord-011917-6u0t4hy8	345	8	ferrets	ferret	NNS
cord-011917-6u0t4hy8	345	9	against	against	IN
cord-011917-6u0t4hy8	345	10	novel	novel	JJ
cord-011917-6u0t4hy8	345	11	2009	2009	CD
cord-011917-6u0t4hy8	345	12	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	345	13	influenza	influenza	NN
cord-011917-6u0t4hy8	345	14	virus	virus	NN
cord-011917-6u0t4hy8	345	15	Sequential	Sequential	NNP
cord-011917-6u0t4hy8	345	16	Infection	infection	NN
cord-011917-6u0t4hy8	345	17	in	in	IN
cord-011917-6u0t4hy8	345	18	Ferrets	ferret	NNS
cord-011917-6u0t4hy8	345	19	with	with	IN
cord-011917-6u0t4hy8	346	1	Antigenically	Antigenically	NNP
cord-011917-6u0t4hy8	346	2	Distinct	Distinct	NNP
cord-011917-6u0t4hy8	346	3	Seasonal	Seasonal	NNP
cord-011917-6u0t4hy8	346	4	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	346	5	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	346	6	Viruses	Viruses	NNPS
cord-011917-6u0t4hy8	346	7	Boosts	boost	VBZ
cord-011917-6u0t4hy8	346	8	Hemagglutinin	Hemagglutinin	NNP
cord-011917-6u0t4hy8	346	9	Stalk	stalk	NN
cord-011917-6u0t4hy8	346	10	-	-	HYPH
cord-011917-6u0t4hy8	346	11	Specific	specific	JJ
cord-011917-6u0t4hy8	346	12	Antibodies	Antibodies	NNPS
cord-011917-6u0t4hy8	346	13	Origins	Origins	NNPS
cord-011917-6u0t4hy8	346	14	and	and	CC
cord-011917-6u0t4hy8	346	15	evolutionary	evolutionary	JJ
cord-011917-6u0t4hy8	346	16	genomics	genomic	NNS
cord-011917-6u0t4hy8	346	17	of	of	IN
cord-011917-6u0t4hy8	346	18	the	the	DT
cord-011917-6u0t4hy8	346	19	2009	2009	CD
cord-011917-6u0t4hy8	346	20	swine	swine	NN
cord-011917-6u0t4hy8	346	21	-	-	HYPH
cord-011917-6u0t4hy8	346	22	origin	origin	NN
cord-011917-6u0t4hy8	346	23	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	346	24	influenza	influenza	NN
cord-011917-6u0t4hy8	346	25	A	a	DT
cord-011917-6u0t4hy8	346	26	epidemic	epidemic	NN
cord-011917-6u0t4hy8	347	1	Classical	classical	JJ
cord-011917-6u0t4hy8	347	2	swine	swine	NN
cord-011917-6u0t4hy8	347	3	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	347	4	influenza	influenza	NN
cord-011917-6u0t4hy8	347	5	viruses	virus	NNS
cord-011917-6u0t4hy8	347	6	confer	confer	VBP
cord-011917-6u0t4hy8	347	7	cross	cross	JJ
cord-011917-6u0t4hy8	347	8	protection	protection	NN
cord-011917-6u0t4hy8	347	9	from	from	IN
cord-011917-6u0t4hy8	347	10	swine	swine	NN
cord-011917-6u0t4hy8	347	11	-	-	HYPH
cord-011917-6u0t4hy8	347	12	origin	origin	NN
cord-011917-6u0t4hy8	347	13	2009	2009	CD
cord-011917-6u0t4hy8	347	14	pandemic	pandemic	NN
cord-011917-6u0t4hy8	347	15	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	347	16	influenza	influenza	NN
cord-011917-6u0t4hy8	347	17	virus	virus	NN
cord-011917-6u0t4hy8	347	18	infection	infection	NN
cord-011917-6u0t4hy8	347	19	in	in	IN
cord-011917-6u0t4hy8	347	20	mice	mouse	NNS
cord-011917-6u0t4hy8	347	21	and	and	CC
cord-011917-6u0t4hy8	347	22	ferrets	ferret	NNS
cord-011917-6u0t4hy8	347	23	Immune	immune	VBP
cord-011917-6u0t4hy8	347	24	history	history	NN
cord-011917-6u0t4hy8	347	25	shapes	shape	VBZ
cord-011917-6u0t4hy8	347	26	specificity	specificity	NN
cord-011917-6u0t4hy8	347	27	of	of	IN
cord-011917-6u0t4hy8	347	28	pandemic	pandemic	NN
cord-011917-6u0t4hy8	348	1	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	348	2	influenza	influenza	NN
cord-011917-6u0t4hy8	348	3	antibody	antibody	NN
cord-011917-6u0t4hy8	348	4	responses	response	NNS
cord-011917-6u0t4hy8	348	5	Defining	define	VBG
cord-011917-6u0t4hy8	348	6	the	the	DT
cord-011917-6u0t4hy8	348	7	antibody	antibody	NN
cord-011917-6u0t4hy8	348	8	cross	cross	NN
cord-011917-6u0t4hy8	348	9	-	-	JJ
cord-011917-6u0t4hy8	348	10	reactome	reactome	VBN
cord-011917-6u0t4hy8	348	11	directed	direct	VBN
cord-011917-6u0t4hy8	348	12	against	against	IN
cord-011917-6u0t4hy8	348	13	the	the	DT
cord-011917-6u0t4hy8	348	14	influenza	influenza	NN
cord-011917-6u0t4hy8	348	15	virus	virus	NN
cord-011917-6u0t4hy8	348	16	surface	surface	NN
cord-011917-6u0t4hy8	348	17	glycoproteins	glycoprotein	NNS
cord-011917-6u0t4hy8	348	18	Imprinting	imprinting	NN
cord-011917-6u0t4hy8	348	19	of	of	IN
cord-011917-6u0t4hy8	348	20	Repeated	repeat	VBN
cord-011917-6u0t4hy8	348	21	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	348	22	A	A	NNP
cord-011917-6u0t4hy8	348	23	/	/	SYM
cord-011917-6u0t4hy8	348	24	H3	H3	NNP
cord-011917-6u0t4hy8	348	25	Exposures	Exposures	NNPS
cord-011917-6u0t4hy8	348	26	on	on	IN
cord-011917-6u0t4hy8	348	27	Antibody	Antibody	NNP
cord-011917-6u0t4hy8	348	28	Quantity	Quantity	NNP
cord-011917-6u0t4hy8	348	29	and	and	CC
cord-011917-6u0t4hy8	348	30	Antibody	Antibody	NNP
cord-011917-6u0t4hy8	348	31	Quality	Quality	NNP
cord-011917-6u0t4hy8	348	32	:	:	:
cord-011917-6u0t4hy8	348	33	Implications	implication	NNS
cord-011917-6u0t4hy8	348	34	for	for	IN
cord-011917-6u0t4hy8	348	35	Seasonal	Seasonal	NNP
cord-011917-6u0t4hy8	348	36	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	348	37	Strain	Strain	NNP
cord-011917-6u0t4hy8	348	38	Selection	Selection	NNP
cord-011917-6u0t4hy8	348	39	and	and	CC
cord-011917-6u0t4hy8	348	40	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	348	41	Performance	Performance	NNP
cord-011917-6u0t4hy8	348	42	Beyond	Beyond	NNP
cord-011917-6u0t4hy8	348	43	Antigenic	Antigenic	NNP
cord-011917-6u0t4hy8	348	44	Match	match	NN
cord-011917-6u0t4hy8	348	45	:	:	:
cord-011917-6u0t4hy8	349	1	Possible	possible	JJ
cord-011917-6u0t4hy8	349	2	Agent	Agent	NNP
cord-011917-6u0t4hy8	349	3	-	-	HYPH
cord-011917-6u0t4hy8	349	4	Host	Host	NNP
cord-011917-6u0t4hy8	349	5	and	and	CC
cord-011917-6u0t4hy8	349	6	Immuno	immuno	JJ
cord-011917-6u0t4hy8	349	7	-	-	HYPH
cord-011917-6u0t4hy8	349	8	epidemiological	epidemiological	JJ
cord-011917-6u0t4hy8	349	9	Influences	influence	NNS
cord-011917-6u0t4hy8	349	10	on	on	IN
cord-011917-6u0t4hy8	349	11	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	349	12	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	349	13	Effectiveness	Effectiveness	NNP
cord-011917-6u0t4hy8	349	14	During	during	IN
cord-011917-6u0t4hy8	349	15	the	the	DT
cord-011917-6u0t4hy8	349	16	2015	2015	CD
cord-011917-6u0t4hy8	349	17	-	-	SYM
cord-011917-6u0t4hy8	349	18	2016	2016	CD
cord-011917-6u0t4hy8	349	19	Season	season	NN
cord-011917-6u0t4hy8	349	20	in	in	IN
cord-011917-6u0t4hy8	349	21	Canada	Canada	NNP
cord-011917-6u0t4hy8	349	22	Impact	Impact	NNP
cord-011917-6u0t4hy8	349	23	of	of	IN
cord-011917-6u0t4hy8	349	24	repeated	repeat	VBN
cord-011917-6u0t4hy8	349	25	vaccination	vaccination	NN
cord-011917-6u0t4hy8	349	26	on	on	IN
cord-011917-6u0t4hy8	349	27	vaccine	vaccine	NN
cord-011917-6u0t4hy8	349	28	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	349	29	against	against	IN
cord-011917-6u0t4hy8	349	30	influenza	influenza	NN
cord-011917-6u0t4hy8	349	31	A(H3N2	A(H3N2	NNP
cord-011917-6u0t4hy8	349	32	)	)	-RRB-
cord-011917-6u0t4hy8	349	33	and	and	CC
cord-011917-6u0t4hy8	349	34	B	b	NN
cord-011917-6u0t4hy8	349	35	during	during	IN
cord-011917-6u0t4hy8	349	36	8	8	CD
cord-011917-6u0t4hy8	349	37	seasons	season	NNS
cord-011917-6u0t4hy8	349	38	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	349	39	vaccine	vaccine	NN
cord-011917-6u0t4hy8	349	40	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	349	41	in	in	IN
cord-011917-6u0t4hy8	349	42	the	the	DT
cord-011917-6u0t4hy8	349	43	2011	2011	CD
cord-011917-6u0t4hy8	349	44	-	-	SYM
cord-011917-6u0t4hy8	349	45	2012	2012	CD
cord-011917-6u0t4hy8	349	46	season	season	NN
cord-011917-6u0t4hy8	350	1	:	:	:
cord-011917-6u0t4hy8	350	2	Protection	protection	NN
cord-011917-6u0t4hy8	350	3	against	against	IN
cord-011917-6u0t4hy8	350	4	each	each	DT
cord-011917-6u0t4hy8	350	5	circulating	circulate	VBG
cord-011917-6u0t4hy8	350	6	virus	virus	NN
cord-011917-6u0t4hy8	350	7	and	and	CC
cord-011917-6u0t4hy8	350	8	the	the	DT
cord-011917-6u0t4hy8	350	9	effect	effect	NN
cord-011917-6u0t4hy8	350	10	of	of	IN
cord-011917-6u0t4hy8	350	11	prior	prior	JJ
cord-011917-6u0t4hy8	350	12	vaccination	vaccination	NN
cord-011917-6u0t4hy8	350	13	on	on	IN
cord-011917-6u0t4hy8	350	14	estimates	estimate	NNS
cord-011917-6u0t4hy8	350	15	Novel	Novel	NNP
cord-011917-6u0t4hy8	350	16	influenza	influenza	NN
cord-011917-6u0t4hy8	350	17	vaccine	vaccine	NN
cord-011917-6u0t4hy8	350	18	M2SR	M2SR	NNP
cord-011917-6u0t4hy8	350	19	protects	protect	VBZ
cord-011917-6u0t4hy8	350	20	against	against	IN
cord-011917-6u0t4hy8	350	21	drifted	drift	VBD
cord-011917-6u0t4hy8	350	22	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	350	23	and	and	CC
cord-011917-6u0t4hy8	350	24	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	350	25	influenza	influenza	NN
cord-011917-6u0t4hy8	350	26	virus	virus	NN
cord-011917-6u0t4hy8	350	27	challenge	challenge	NN
cord-011917-6u0t4hy8	350	28	in	in	IN
cord-011917-6u0t4hy8	350	29	ferrets	ferret	NNS
cord-011917-6u0t4hy8	350	30	with	with	IN
cord-011917-6u0t4hy8	350	31	pre	pre	JJ
cord-011917-6u0t4hy8	350	32	-	-	JJ
cord-011917-6u0t4hy8	350	33	existing	existing	JJ
cord-011917-6u0t4hy8	350	34	immunity	immunity	NN
cord-011917-6u0t4hy8	351	1	Antigenically	antigenically	RB
cord-011917-6u0t4hy8	351	2	Diverse	diverse	JJ
cord-011917-6u0t4hy8	351	3	Swine	Swine	NNP
cord-011917-6u0t4hy8	351	4	Origin	Origin	NNP
cord-011917-6u0t4hy8	351	5	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	351	6	Variant	Variant	NNP
cord-011917-6u0t4hy8	351	7	Influenza	influenza	NN
cord-011917-6u0t4hy8	351	8	Viruses	Viruses	NNPS
cord-011917-6u0t4hy8	351	9	Exhibit	exhibit	VBP
cord-011917-6u0t4hy8	351	10	Differential	differential	JJ
cord-011917-6u0t4hy8	351	11	Ferret	Ferret	NNP
cord-011917-6u0t4hy8	351	12	Pathogenesis	Pathogenesis	NNP
cord-011917-6u0t4hy8	351	13	and	and	CC
cord-011917-6u0t4hy8	351	14	Transmission	Transmission	NNP
cord-011917-6u0t4hy8	351	15	Phenotypes	Phenotypes	NNP
cord-011917-6u0t4hy8	351	16	Characterization	characterization	NN
cord-011917-6u0t4hy8	351	17	of	of	IN
cord-011917-6u0t4hy8	351	18	co	co	JJ
cord-011917-6u0t4hy8	351	19	-	-	JJ
cord-011917-6u0t4hy8	351	20	circulating	circulating	JJ
cord-011917-6u0t4hy8	351	21	swine	swine	NN
cord-011917-6u0t4hy8	351	22	influenza	influenza	NN
cord-011917-6u0t4hy8	351	23	A	a	DT
cord-011917-6u0t4hy8	351	24	viruses	virus	NNS
cord-011917-6u0t4hy8	351	25	in	in	IN
cord-011917-6u0t4hy8	351	26	North	North	NNP
cord-011917-6u0t4hy8	351	27	America	America	NNP
cord-011917-6u0t4hy8	351	28	and	and	CC
cord-011917-6u0t4hy8	351	29	the	the	DT
cord-011917-6u0t4hy8	351	30	identification	identification	NN
cord-011917-6u0t4hy8	351	31	of	of	IN
cord-011917-6u0t4hy8	351	32	a	a	DT
cord-011917-6u0t4hy8	351	33	novel	novel	JJ
cord-011917-6u0t4hy8	351	34	H1	h1	NN
cord-011917-6u0t4hy8	351	35	genetic	genetic	JJ
cord-011917-6u0t4hy8	351	36	clade	clade	NN
cord-011917-6u0t4hy8	351	37	with	with	IN
cord-011917-6u0t4hy8	351	38	antigenic	antigenic	JJ
cord-011917-6u0t4hy8	351	39	significance	significance	NN
cord-011917-6u0t4hy8	351	40	Pathogenesis	Pathogenesis	NNP
cord-011917-6u0t4hy8	351	41	and	and	CC
cord-011917-6u0t4hy8	351	42	transmission	transmission	NN
cord-011917-6u0t4hy8	351	43	of	of	IN
cord-011917-6u0t4hy8	351	44	swine	swine	NN
cord-011917-6u0t4hy8	351	45	origin	origin	NN
cord-011917-6u0t4hy8	351	46	A(H3N2)v	a(h3n2)v	NN
cord-011917-6u0t4hy8	351	47	influenza	influenza	NN
cord-011917-6u0t4hy8	351	48	viruses	virus	NNS
cord-011917-6u0t4hy8	351	49	in	in	IN
cord-011917-6u0t4hy8	351	50	ferrets	ferret	NNS
cord-011917-6u0t4hy8	351	51	Sequencing	Sequencing	NNP
cord-011917-6u0t4hy8	351	52	,	,	,
cord-011917-6u0t4hy8	351	53	annotation	annotation	NN
cord-011917-6u0t4hy8	351	54	,	,	,
cord-011917-6u0t4hy8	351	55	and	and	CC
cord-011917-6u0t4hy8	351	56	characterization	characterization	NN
cord-011917-6u0t4hy8	351	57	of	of	IN
cord-011917-6u0t4hy8	351	58	the	the	DT
cord-011917-6u0t4hy8	351	59	influenza	influenza	NN
cord-011917-6u0t4hy8	351	60	ferret	ferret	NNP
cord-011917-6u0t4hy8	351	61	infectome	infectome	NNP
cord-011917-6u0t4hy8	351	62	Heterosubtypic	Heterosubtypic	NNP
cord-011917-6u0t4hy8	351	63	cross	cross	NN
cord-011917-6u0t4hy8	351	64	-	-	NN
cord-011917-6u0t4hy8	351	65	protection	protection	JJ
cord-011917-6u0t4hy8	351	66	correlates	correlate	VBZ
cord-011917-6u0t4hy8	351	67	with	with	IN
cord-011917-6u0t4hy8	351	68	cross	cross	JJ
cord-011917-6u0t4hy8	351	69	-	-	JJ
cord-011917-6u0t4hy8	351	70	reactive	reactive	JJ
cord-011917-6u0t4hy8	351	71	interferon	interferon	NN
cord-011917-6u0t4hy8	351	72	-	-	HYPH
cord-011917-6u0t4hy8	351	73	gamma	gamma	NN
cord-011917-6u0t4hy8	351	74	-	-	HYPH
cord-011917-6u0t4hy8	351	75	secreting	secrete	VBG
cord-011917-6u0t4hy8	351	76	lymphocytes	lymphocyte	NNS
cord-011917-6u0t4hy8	351	77	in	in	IN
cord-011917-6u0t4hy8	351	78	the	the	DT
cord-011917-6u0t4hy8	351	79	ferret	ferret	JJ
cord-011917-6u0t4hy8	351	80	model	model	NN
cord-011917-6u0t4hy8	351	81	of	of	IN
cord-011917-6u0t4hy8	351	82	influenza	influenza	NN
cord-011917-6u0t4hy8	351	83	Characterising	characterise	VBG
cord-011917-6u0t4hy8	351	84	antibody	antibody	NN
cord-011917-6u0t4hy8	351	85	kinetics	kinetics	NN
cord-011917-6u0t4hy8	351	86	from	from	IN
cord-011917-6u0t4hy8	351	87	multiple	multiple	JJ
cord-011917-6u0t4hy8	351	88	influenza	influenza	NN
cord-011917-6u0t4hy8	351	89	infection	infection	NN
cord-011917-6u0t4hy8	351	90	and	and	CC
cord-011917-6u0t4hy8	351	91	vaccination	vaccination	NN
cord-011917-6u0t4hy8	351	92	events	event	NNS
cord-011917-6u0t4hy8	351	93	in	in	IN
cord-011917-6u0t4hy8	351	94	ferrets	ferret	NNS
cord-011917-6u0t4hy8	352	1	Heterologous	heterologous	JJ
cord-011917-6u0t4hy8	352	2	protection	protection	NN
cord-011917-6u0t4hy8	352	3	against	against	IN
cord-011917-6u0t4hy8	352	4	lethal	lethal	JJ
cord-011917-6u0t4hy8	352	5	A	A	NNP
cord-011917-6u0t4hy8	352	6	/	/	,
cord-011917-6u0t4hy8	352	7	HongKong/156/97	HongKong/156/97	NNP
cord-011917-6u0t4hy8	352	8	(	(	-LRB-
cord-011917-6u0t4hy8	352	9	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	352	10	)	)	-RRB-
cord-011917-6u0t4hy8	353	1	influenza	influenza	NN
cord-011917-6u0t4hy8	353	2	virus	virus	NN
cord-011917-6u0t4hy8	353	3	infection	infection	NN
cord-011917-6u0t4hy8	353	4	in	in	IN
cord-011917-6u0t4hy8	353	5	C57BL/6	C57BL/6	NNP
cord-011917-6u0t4hy8	353	6	mice	mouse	NNS
cord-011917-6u0t4hy8	353	7	Infection	infection	NN
cord-011917-6u0t4hy8	353	8	of	of	IN
cord-011917-6u0t4hy8	353	9	mice	mouse	NNS
cord-011917-6u0t4hy8	353	10	with	with	IN
cord-011917-6u0t4hy8	353	11	a	a	DT
cord-011917-6u0t4hy8	353	12	human	human	JJ
cord-011917-6u0t4hy8	353	13	influenza	influenza	NN
cord-011917-6u0t4hy8	353	14	A	a	NN
cord-011917-6u0t4hy8	353	15	/	/	SYM
cord-011917-6u0t4hy8	353	16	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	353	17	virus	virus	NN
cord-011917-6u0t4hy8	353	18	induces	induce	VBZ
cord-011917-6u0t4hy8	353	19	protective	protective	JJ
cord-011917-6u0t4hy8	353	20	immunity	immunity	NN
cord-011917-6u0t4hy8	353	21	against	against	IN
cord-011917-6u0t4hy8	353	22	lethal	lethal	JJ
cord-011917-6u0t4hy8	353	23	infection	infection	NN
cord-011917-6u0t4hy8	353	24	with	with	IN
cord-011917-6u0t4hy8	354	1	influenza	influenza	NNP
cord-011917-6u0t4hy8	354	2	A	A	NNP
cord-011917-6u0t4hy8	354	3	/	/	SYM
cord-011917-6u0t4hy8	354	4	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	354	5	virus	virus	NN
cord-011917-6u0t4hy8	354	6	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	354	7	vaccine	vaccine	NN
cord-011917-6u0t4hy8	354	8	-	-	HYPH
cord-011917-6u0t4hy8	354	9	specific	specific	JJ
cord-011917-6u0t4hy8	354	10	B	b	NN
cord-011917-6u0t4hy8	354	11	cell	cell	NN
cord-011917-6u0t4hy8	354	12	responses	response	NNS
cord-011917-6u0t4hy8	354	13	in	in	IN
cord-011917-6u0t4hy8	354	14	ferrets	ferret	NNS
cord-011917-6u0t4hy8	354	15	primed	prime	VBN
cord-011917-6u0t4hy8	354	16	with	with	IN
cord-011917-6u0t4hy8	354	17	live	live	JJ
cord-011917-6u0t4hy8	354	18	attenuated	attenuated	JJ
cord-011917-6u0t4hy8	354	19	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	354	20	influenza	influenza	NN
cord-011917-6u0t4hy8	354	21	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	354	22	Induction	Induction	NNP
cord-011917-6u0t4hy8	354	23	of	of	IN
cord-011917-6u0t4hy8	354	24	Partial	partial	JJ
cord-011917-6u0t4hy8	354	25	Specific	specific	JJ
cord-011917-6u0t4hy8	354	26	Heterotypic	Heterotypic	NNP
cord-011917-6u0t4hy8	354	27	Immunity	Immunity	NNP
cord-011917-6u0t4hy8	354	28	in	in	IN
cord-011917-6u0t4hy8	354	29	Mice	mouse	NNS
cord-011917-6u0t4hy8	354	30	by	by	IN
cord-011917-6u0t4hy8	354	31	a	a	DT
cord-011917-6u0t4hy8	354	32	Single	single	JJ
cord-011917-6u0t4hy8	354	33	Infection	infection	NN
cord-011917-6u0t4hy8	354	34	with	with	IN
cord-011917-6u0t4hy8	354	35	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	354	36	a	a	DT
cord-011917-6u0t4hy8	354	37	Virus	Virus	NNP
cord-011917-6u0t4hy8	354	38	Cross	Cross	NNP
cord-011917-6u0t4hy8	354	39	-	-	NNP
cord-011917-6u0t4hy8	354	40	Protective	Protective	NNP
cord-011917-6u0t4hy8	354	41	Immune	Immune	NNP
cord-011917-6u0t4hy8	354	42	Responses	response	NNS
cord-011917-6u0t4hy8	354	43	Induced	induce	VBN
cord-011917-6u0t4hy8	354	44	by	by	IN
cord-011917-6u0t4hy8	354	45	Sequential	Sequential	NNP
cord-011917-6u0t4hy8	354	46	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	354	47	Virus	Virus	NNP
cord-011917-6u0t4hy8	354	48	Infection	infection	NN
cord-011917-6u0t4hy8	354	49	and	and	CC
cord-011917-6u0t4hy8	354	50	by	by	IN
cord-011917-6u0t4hy8	354	51	Sequential	sequential	JJ
cord-011917-6u0t4hy8	354	52	Vaccination	vaccination	NN
cord-011917-6u0t4hy8	354	53	With	with	IN
cord-011917-6u0t4hy8	354	54	Inactivated	inactivate	VBN
cord-011917-6u0t4hy8	354	55	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	354	56	Vaccines	Vaccines	NNPS
cord-011917-6u0t4hy8	354	57	Primary	Primary	NNP
cord-011917-6u0t4hy8	354	58	influenza	influenza	NN
cord-011917-6u0t4hy8	354	59	A	a	DT
cord-011917-6u0t4hy8	354	60	virus	virus	NN
cord-011917-6u0t4hy8	354	61	infection	infection	NN
cord-011917-6u0t4hy8	354	62	induces	induce	VBZ
cord-011917-6u0t4hy8	354	63	cross	cross	JJ
cord-011917-6u0t4hy8	354	64	-	-	JJ
cord-011917-6u0t4hy8	354	65	protective	protective	JJ
cord-011917-6u0t4hy8	354	66	immunity	immunity	NN
cord-011917-6u0t4hy8	354	67	against	against	IN
cord-011917-6u0t4hy8	354	68	a	a	DT
cord-011917-6u0t4hy8	354	69	lethal	lethal	JJ
cord-011917-6u0t4hy8	354	70	infection	infection	NN
cord-011917-6u0t4hy8	354	71	with	with	IN
cord-011917-6u0t4hy8	354	72	a	a	DT
cord-011917-6u0t4hy8	354	73	heterosubtypic	heterosubtypic	JJ
cord-011917-6u0t4hy8	354	74	virus	virus	NN
cord-011917-6u0t4hy8	354	75	strain	strain	NN
cord-011917-6u0t4hy8	354	76	in	in	IN
cord-011917-6u0t4hy8	354	77	mice	mouse	NNS
cord-011917-6u0t4hy8	354	78	Outcome	outcome	NN
cord-011917-6u0t4hy8	354	79	of	of	IN
cord-011917-6u0t4hy8	354	80	influenza	influenza	NN
cord-011917-6u0t4hy8	354	81	infection	infection	NN
cord-011917-6u0t4hy8	354	82	:	:	:
cord-011917-6u0t4hy8	354	83	Effect	effect	NN
cord-011917-6u0t4hy8	354	84	of	of	IN
cord-011917-6u0t4hy8	354	85	site	site	NN
cord-011917-6u0t4hy8	354	86	of	of	IN
cord-011917-6u0t4hy8	354	87	initial	initial	JJ
cord-011917-6u0t4hy8	354	88	infection	infection	NN
cord-011917-6u0t4hy8	354	89	and	and	CC
cord-011917-6u0t4hy8	354	90	heterotypic	heterotypic	NNP
cord-011917-6u0t4hy8	354	91	immunity	immunity	NN
cord-011917-6u0t4hy8	354	92	Transmission	Transmission	NNP
cord-011917-6u0t4hy8	354	93	of	of	IN
cord-011917-6u0t4hy8	354	94	pandemic	pandemic	NN
cord-011917-6u0t4hy8	354	95	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	354	96	influenza	influenza	NN
cord-011917-6u0t4hy8	354	97	virus	virus	NN
cord-011917-6u0t4hy8	354	98	and	and	CC
cord-011917-6u0t4hy8	354	99	impact	impact	NN
cord-011917-6u0t4hy8	354	100	of	of	IN
cord-011917-6u0t4hy8	354	101	prior	prior	JJ
cord-011917-6u0t4hy8	354	102	exposure	exposure	NN
cord-011917-6u0t4hy8	354	103	to	to	IN
cord-011917-6u0t4hy8	354	104	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	354	105	strains	strain	NNS
cord-011917-6u0t4hy8	354	106	or	or	CC
cord-011917-6u0t4hy8	354	107	interferon	interferon	NN
cord-011917-6u0t4hy8	354	108	treatment	treatment	NN
cord-011917-6u0t4hy8	354	109	Low	Low	NNP
cord-011917-6u0t4hy8	354	110	dose	dose	NN
cord-011917-6u0t4hy8	354	111	influenza	influenza	NN
cord-011917-6u0t4hy8	354	112	virus	virus	NN
cord-011917-6u0t4hy8	354	113	challenge	challenge	NN
cord-011917-6u0t4hy8	354	114	in	in	IN
cord-011917-6u0t4hy8	354	115	the	the	DT
cord-011917-6u0t4hy8	354	116	ferret	ferret	NN
cord-011917-6u0t4hy8	354	117	leads	lead	VBZ
cord-011917-6u0t4hy8	354	118	to	to	IN
cord-011917-6u0t4hy8	354	119	increased	increase	VBN
cord-011917-6u0t4hy8	354	120	virus	virus	NN
cord-011917-6u0t4hy8	354	121	shedding	shed	VBG
cord-011917-6u0t4hy8	354	122	and	and	CC
cord-011917-6u0t4hy8	354	123	greater	great	JJR
cord-011917-6u0t4hy8	354	124	sensitivity	sensitivity	NN
cord-011917-6u0t4hy8	354	125	to	to	IN
cord-011917-6u0t4hy8	354	126	oseltamivir	oseltamivir	FW
cord-011917-6u0t4hy8	354	127	Sex	sex	NN
cord-011917-6u0t4hy8	354	128	differences	difference	NNS
cord-011917-6u0t4hy8	354	129	in	in	IN
cord-011917-6u0t4hy8	354	130	vaccine	vaccine	NN
cord-011917-6u0t4hy8	354	131	-	-	HYPH
cord-011917-6u0t4hy8	354	132	induced	induce	VBN
cord-011917-6u0t4hy8	354	133	humoral	humoral	JJ
cord-011917-6u0t4hy8	354	134	immunity	immunity	NN
cord-011917-6u0t4hy8	355	1	The	the	DT
cord-011917-6u0t4hy8	355	2	pathology	pathology	NN
cord-011917-6u0t4hy8	355	3	and	and	CC
cord-011917-6u0t4hy8	355	4	pathogenesis	pathogenesis	NN
cord-011917-6u0t4hy8	355	5	of	of	IN
cord-011917-6u0t4hy8	355	6	experimental	experimental	JJ
cord-011917-6u0t4hy8	355	7	severe	severe	JJ
cord-011917-6u0t4hy8	355	8	acute	acute	JJ
cord-011917-6u0t4hy8	355	9	respiratory	respiratory	JJ
cord-011917-6u0t4hy8	355	10	syndrome	syndrome	NN
cord-011917-6u0t4hy8	355	11	and	and	CC
cord-011917-6u0t4hy8	355	12	influenza	influenza	NN
cord-011917-6u0t4hy8	355	13	in	in	IN
cord-011917-6u0t4hy8	355	14	animal	animal	NN
cord-011917-6u0t4hy8	355	15	models	model	NNS
cord-011917-6u0t4hy8	355	16	Mouse	Mouse	NNP
cord-011917-6u0t4hy8	355	17	Vendor	Vendor	NNP
cord-011917-6u0t4hy8	355	18	Influence	Influence	NNP
cord-011917-6u0t4hy8	355	19	on	on	IN
cord-011917-6u0t4hy8	355	20	the	the	DT
cord-011917-6u0t4hy8	355	21	Bacterial	bacterial	JJ
cord-011917-6u0t4hy8	355	22	and	and	CC
cord-011917-6u0t4hy8	355	23	Viral	Viral	NNP
cord-011917-6u0t4hy8	355	24	Gut	Gut	NNP
cord-011917-6u0t4hy8	355	25	Composition	composition	NN
cord-011917-6u0t4hy8	355	26	Exceeds	exceed	VBZ
cord-011917-6u0t4hy8	355	27	the	the	DT
cord-011917-6u0t4hy8	355	28	Effect	Effect	NNP
cord-011917-6u0t4hy8	355	29	of	of	IN
cord-011917-6u0t4hy8	355	30	Diet	Diet	NNP
cord-011917-6u0t4hy8	355	31	Variation	Variation	NNP
cord-011917-6u0t4hy8	355	32	in	in	IN
cord-011917-6u0t4hy8	355	33	the	the	DT
cord-011917-6u0t4hy8	355	34	gut	gut	NN
cord-011917-6u0t4hy8	355	35	microbiota	microbiota	NN
cord-011917-6u0t4hy8	355	36	of	of	IN
cord-011917-6u0t4hy8	355	37	laboratory	laboratory	NN
cord-011917-6u0t4hy8	355	38	mice	mouse	NNS
cord-011917-6u0t4hy8	356	1	is	be	VBZ
cord-011917-6u0t4hy8	356	2	related	relate	VBN
cord-011917-6u0t4hy8	356	3	to	to	IN
cord-011917-6u0t4hy8	356	4	both	both	CC
cord-011917-6u0t4hy8	356	5	genetic	genetic	JJ
cord-011917-6u0t4hy8	356	6	and	and	CC
cord-011917-6u0t4hy8	356	7	environmental	environmental	JJ
cord-011917-6u0t4hy8	356	8	factors	factor	NNS
cord-011917-6u0t4hy8	357	1	The	the	DT
cord-011917-6u0t4hy8	357	2	Lung	Lung	NNP
cord-011917-6u0t4hy8	357	3	Microbiota	Microbiota	NNP
cord-011917-6u0t4hy8	357	4	of	of	IN
cord-011917-6u0t4hy8	357	5	Healthy	Healthy	NNP
cord-011917-6u0t4hy8	357	6	Mice	mouse	NNS
cord-011917-6u0t4hy8	357	7	Are	be	VBP
cord-011917-6u0t4hy8	357	8	Highly	highly	RB
cord-011917-6u0t4hy8	357	9	Variable	variable	JJ
cord-011917-6u0t4hy8	357	10	,	,	,
cord-011917-6u0t4hy8	357	11	Cluster	Cluster	NNP
cord-011917-6u0t4hy8	357	12	by	by	IN
cord-011917-6u0t4hy8	357	13	Environment	Environment	NNP
cord-011917-6u0t4hy8	357	14	,	,	,
cord-011917-6u0t4hy8	357	15	and	and	CC
cord-011917-6u0t4hy8	357	16	Reflect	reflect	VB
cord-011917-6u0t4hy8	357	17	Variation	variation	NN
cord-011917-6u0t4hy8	357	18	in	in	IN
cord-011917-6u0t4hy8	357	19	Baseline	Baseline	NNP
cord-011917-6u0t4hy8	357	20	Lung	Lung	NNP
cord-011917-6u0t4hy8	357	21	Innate	Innate	NNP
cord-011917-6u0t4hy8	357	22	Immunity	Immunity	NNP
cord-011917-6u0t4hy8	357	23	Role	role	NN
cord-011917-6u0t4hy8	357	24	of	of	IN
cord-011917-6u0t4hy8	357	25	the	the	DT
cord-011917-6u0t4hy8	357	26	intestinal	intestinal	JJ
cord-011917-6u0t4hy8	357	27	microbiota	microbiota	NN
cord-011917-6u0t4hy8	357	28	in	in	IN
cord-011917-6u0t4hy8	357	29	the	the	DT
cord-011917-6u0t4hy8	357	30	immunomodulation	immunomodulation	NN
cord-011917-6u0t4hy8	357	31	of	of	IN
cord-011917-6u0t4hy8	357	32	influenza	influenza	NN
cord-011917-6u0t4hy8	357	33	virus	virus	NN
cord-011917-6u0t4hy8	357	34	infection	infection	NN
cord-011917-6u0t4hy8	358	1	TLR5-mediated	tlr5-mediated	JJ
cord-011917-6u0t4hy8	358	2	sensing	sensing	NN
cord-011917-6u0t4hy8	358	3	of	of	IN
cord-011917-6u0t4hy8	358	4	gut	gut	NN
cord-011917-6u0t4hy8	358	5	microbiota	microbiota	NN
cord-011917-6u0t4hy8	358	6	is	be	VBZ
cord-011917-6u0t4hy8	358	7	necessary	necessary	JJ
cord-011917-6u0t4hy8	358	8	for	for	IN
cord-011917-6u0t4hy8	358	9	antibody	antibody	NN
cord-011917-6u0t4hy8	358	10	responses	response	NNS
cord-011917-6u0t4hy8	358	11	to	to	IN
cord-011917-6u0t4hy8	359	1	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	359	2	influenza	influenza	NN
cord-011917-6u0t4hy8	359	3	vaccination	vaccination	NN
cord-011917-6u0t4hy8	359	4	Antibiotics	Antibiotics	NNP
cord-011917-6u0t4hy8	359	5	-	-	HYPH
cord-011917-6u0t4hy8	359	6	Driven	drive	VBN
cord-011917-6u0t4hy8	359	7	Gut	Gut	NNP
cord-011917-6u0t4hy8	359	8	Microbiome	microbiome	NN
cord-011917-6u0t4hy8	359	9	Perturbation	perturbation	NN
cord-011917-6u0t4hy8	359	10	Alters	alter	VBZ
cord-011917-6u0t4hy8	359	11	Immunity	immunity	NN
cord-011917-6u0t4hy8	359	12	to	to	IN
cord-011917-6u0t4hy8	359	13	Vaccines	vaccine	NNS
cord-011917-6u0t4hy8	359	14	in	in	IN
cord-011917-6u0t4hy8	359	15	Humans	Humans	NNPS
cord-011917-6u0t4hy8	359	16	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	359	17	vaccine	vaccine	NN
cord-011917-6u0t4hy8	359	18	responses	response	NNS
cord-011917-6u0t4hy8	359	19	in	in	IN
cord-011917-6u0t4hy8	359	20	older	old	JJR
cord-011917-6u0t4hy8	359	21	adults	adult	NNS
cord-011917-6u0t4hy8	359	22	Understanding	understand	VBG
cord-011917-6u0t4hy8	359	23	the	the	DT
cord-011917-6u0t4hy8	359	24	burden	burden	NN
cord-011917-6u0t4hy8	359	25	of	of	IN
cord-011917-6u0t4hy8	359	26	influenza	influenza	NN
cord-011917-6u0t4hy8	359	27	infection	infection	NN
cord-011917-6u0t4hy8	359	28	among	among	IN
cord-011917-6u0t4hy8	359	29	adults	adult	NNS
cord-011917-6u0t4hy8	359	30	in	in	IN
cord-011917-6u0t4hy8	359	31	Canadian	canadian	JJ
cord-011917-6u0t4hy8	359	32	hospitals	hospital	NNS
cord-011917-6u0t4hy8	359	33	:	:	:
cord-011917-6u0t4hy8	360	1	A	a	DT
cord-011917-6u0t4hy8	360	2	comparison	comparison	NN
cord-011917-6u0t4hy8	360	3	of	of	IN
cord-011917-6u0t4hy8	360	4	the	the	DT
cord-011917-6u0t4hy8	360	5	2009	2009	CD
cord-011917-6u0t4hy8	360	6	-	-	SYM
cord-011917-6u0t4hy8	360	7	2010	2010	CD
cord-011917-6u0t4hy8	360	8	pandemic	pandemic	NN
cord-011917-6u0t4hy8	360	9	season	season	NN
cord-011917-6u0t4hy8	360	10	with	with	IN
cord-011917-6u0t4hy8	360	11	the	the	DT
cord-011917-6u0t4hy8	360	12	prepandemic	prepandemic	NNP
cord-011917-6u0t4hy8	360	13	and	and	CC
cord-011917-6u0t4hy8	360	14	postpandemic	postpandemic	NNP
cord-011917-6u0t4hy8	360	15	seasons	season	NNS
cord-011917-6u0t4hy8	361	1	The	the	DT
cord-011917-6u0t4hy8	361	2	Pathway	Pathway	NNP
cord-011917-6u0t4hy8	361	3	to	to	IN
cord-011917-6u0t4hy8	361	4	a	a	DT
cord-011917-6u0t4hy8	361	5	Universal	Universal	NNP
cord-011917-6u0t4hy8	361	6	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	361	7	Vaccine	Vaccine	NNP
cord-011917-6u0t4hy8	361	8	Repeated	repeat	VBD
cord-011917-6u0t4hy8	361	9	annual	annual	JJ
cord-011917-6u0t4hy8	361	10	influenza	influenza	NN
cord-011917-6u0t4hy8	361	11	vaccination	vaccination	NN
cord-011917-6u0t4hy8	361	12	and	and	CC
cord-011917-6u0t4hy8	361	13	vaccine	vaccine	NN
cord-011917-6u0t4hy8	361	14	effectiveness	effectiveness	NN
cord-011917-6u0t4hy8	361	15	:	:	:
cord-011917-6u0t4hy8	362	1	Review	Review	NNP
cord-011917-6u0t4hy8	362	2	of	of	IN
cord-011917-6u0t4hy8	362	3	evidence	evidence	NN
cord-011917-6u0t4hy8	362	4	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	362	5	Infection	infection	NN
cord-011917-6u0t4hy8	362	6	in	in	IN
cord-011917-6u0t4hy8	362	7	Humans	Humans	NNPS
cord-011917-6u0t4hy8	362	8	Induces	induce	VBZ
cord-011917-6u0t4hy8	362	9	Broadly	Broadly	NNP
cord-011917-6u0t4hy8	362	10	Cross	Cross	NNP
cord-011917-6u0t4hy8	362	11	-	-	NNP
cord-011917-6u0t4hy8	362	12	Reactive	Reactive	NNP
cord-011917-6u0t4hy8	362	13	and	and	CC
cord-011917-6u0t4hy8	362	14	Protective	Protective	NNP
cord-011917-6u0t4hy8	362	15	Neuraminidase	Neuraminidase	NNP
cord-011917-6u0t4hy8	362	16	-	-	HYPH
cord-011917-6u0t4hy8	362	17	Reactive	Reactive	NNP
cord-011917-6u0t4hy8	362	18	Antibodies	Antibodies	NNPS
cord-011917-6u0t4hy8	362	19	Impact	Impact	NNP
cord-011917-6u0t4hy8	362	20	of	of	IN
cord-011917-6u0t4hy8	362	21	age	age	NN
cord-011917-6u0t4hy8	362	22	and	and	CC
cord-011917-6u0t4hy8	362	23	pre	pre	JJ
cord-011917-6u0t4hy8	362	24	-	-	JJ
cord-011917-6u0t4hy8	362	25	existing	existing	JJ
cord-011917-6u0t4hy8	362	26	influenza	influenza	NN
cord-011917-6u0t4hy8	362	27	immune	immune	JJ
cord-011917-6u0t4hy8	362	28	responses	response	NNS
cord-011917-6u0t4hy8	362	29	in	in	IN
cord-011917-6u0t4hy8	362	30	humans	human	NNS
cord-011917-6u0t4hy8	362	31	receiving	receive	VBG
cord-011917-6u0t4hy8	362	32	split	split	NN
cord-011917-6u0t4hy8	362	33	inactivated	inactivate	VBN
cord-011917-6u0t4hy8	362	34	influenza	influenza	NN
cord-011917-6u0t4hy8	362	35	vaccine	vaccine	NN
cord-011917-6u0t4hy8	362	36	on	on	IN
cord-011917-6u0t4hy8	362	37	the	the	DT
cord-011917-6u0t4hy8	362	38	induction	induction	NN
cord-011917-6u0t4hy8	362	39	of	of	IN
cord-011917-6u0t4hy8	362	40	the	the	DT
cord-011917-6u0t4hy8	362	41	breadth	breadth	NN
cord-011917-6u0t4hy8	362	42	of	of	IN
cord-011917-6u0t4hy8	362	43	antibodies	antibody	NNS
cord-011917-6u0t4hy8	362	44	to	to	TO
cord-011917-6u0t4hy8	362	45	influenza	influenza	VB
cord-011917-6u0t4hy8	362	46	A	a	DT
cord-011917-6u0t4hy8	362	47	strains	strain	NNS
cord-011917-6u0t4hy8	362	48	Impact	impact	NN
cord-011917-6u0t4hy8	362	49	of	of	IN
cord-011917-6u0t4hy8	362	50	age	age	NN
cord-011917-6u0t4hy8	362	51	and	and	CC
cord-011917-6u0t4hy8	362	52	pre	pre	JJ
cord-011917-6u0t4hy8	362	53	-	-	JJ
cord-011917-6u0t4hy8	362	54	existing	existing	JJ
cord-011917-6u0t4hy8	362	55	immunity	immunity	NN
cord-011917-6u0t4hy8	362	56	on	on	IN
cord-011917-6u0t4hy8	362	57	the	the	DT
cord-011917-6u0t4hy8	362	58	induction	induction	NN
cord-011917-6u0t4hy8	362	59	of	of	IN
cord-011917-6u0t4hy8	362	60	human	human	JJ
cord-011917-6u0t4hy8	362	61	antibody	antibody	NN
cord-011917-6u0t4hy8	362	62	responses	response	NNS
cord-011917-6u0t4hy8	362	63	against	against	IN
cord-011917-6u0t4hy8	362	64	influenza	influenza	NN
cord-011917-6u0t4hy8	362	65	B	b	NN
cord-011917-6u0t4hy8	362	66	viruses	virus	NNS
cord-011917-6u0t4hy8	362	67	.	.	.
cord-011917-6u0t4hy8	363	1	Hum	Hum	NNP
cord-011917-6u0t4hy8	363	2	.	.	.
cord-011917-6u0t4hy8	364	1	Vaccines	vaccine	NNS
cord-011917-6u0t4hy8	364	2	Immunother	Immunother	NNP
cord-011917-6u0t4hy8	364	3	Annually	annually	RB
cord-011917-6u0t4hy8	364	4	repeated	repeat	VBD
cord-011917-6u0t4hy8	364	5	influenza	influenza	NN
cord-011917-6u0t4hy8	364	6	vaccination	vaccination	NN
cord-011917-6u0t4hy8	364	7	improves	improve	VBZ
cord-011917-6u0t4hy8	364	8	humoral	humoral	JJ
cord-011917-6u0t4hy8	364	9	responses	response	NNS
cord-011917-6u0t4hy8	364	10	to	to	IN
cord-011917-6u0t4hy8	364	11	several	several	JJ
cord-011917-6u0t4hy8	364	12	influenza	influenza	NN
cord-011917-6u0t4hy8	364	13	virus	virus	NN
cord-011917-6u0t4hy8	364	14	strains	strain	NNS
cord-011917-6u0t4hy8	364	15	in	in	IN
cord-011917-6u0t4hy8	364	16	healthy	healthy	JJ
cord-011917-6u0t4hy8	364	17	elderly	elderly	JJ
cord-011917-6u0t4hy8	364	18	Antibody	Antibody	NNP
cord-011917-6u0t4hy8	364	19	response	response	NN
cord-011917-6u0t4hy8	364	20	to	to	IN
cord-011917-6u0t4hy8	364	21	whole	whole	JJ
cord-011917-6u0t4hy8	364	22	-	-	HYPH
cord-011917-6u0t4hy8	364	23	virus	virus	NN
cord-011917-6u0t4hy8	364	24	and	and	CC
cord-011917-6u0t4hy8	364	25	split	split	NN
cord-011917-6u0t4hy8	364	26	-	-	HYPH
cord-011917-6u0t4hy8	364	27	virus	virus	NN
cord-011917-6u0t4hy8	364	28	influenza	influenza	NN
cord-011917-6u0t4hy8	364	29	vaccines	vaccine	NNS
cord-011917-6u0t4hy8	364	30	in	in	IN
cord-011917-6u0t4hy8	364	31	successful	successful	JJ
cord-011917-6u0t4hy8	364	32	ageing	age	VBG
cord-011917-6u0t4hy8	364	33	Cellular	cellular	JJ
cord-011917-6u0t4hy8	364	34	immune	immune	JJ
cord-011917-6u0t4hy8	364	35	response	response	NN
cord-011917-6u0t4hy8	364	36	to	to	IN
cord-011917-6u0t4hy8	364	37	human	human	JJ
cord-011917-6u0t4hy8	364	38	influenza	influenza	NN
cord-011917-6u0t4hy8	364	39	viruses	virus	NNS
cord-011917-6u0t4hy8	364	40	differs	differ	VBZ
cord-011917-6u0t4hy8	364	41	between	between	IN
cord-011917-6u0t4hy8	364	42	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	364	43	and	and	CC
cord-011917-6u0t4hy8	364	44	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	364	45	subtypes	subtype	NNS
cord-011917-6u0t4hy8	364	46	in	in	IN
cord-011917-6u0t4hy8	364	47	the	the	DT
cord-011917-6u0t4hy8	364	48	ferret	ferret	NN
cord-011917-6u0t4hy8	364	49	lung	lung	NN
cord-011917-6u0t4hy8	364	50	Gene	Gene	NNP
cord-011917-6u0t4hy8	364	51	expression	expression	NN
cord-011917-6u0t4hy8	364	52	analysis	analysis	NN
cord-011917-6u0t4hy8	364	53	of	of	IN
cord-011917-6u0t4hy8	364	54	host	host	NN
cord-011917-6u0t4hy8	364	55	innate	innate	JJ
cord-011917-6u0t4hy8	364	56	immune	immune	JJ
cord-011917-6u0t4hy8	364	57	responses	response	NNS
cord-011917-6u0t4hy8	364	58	during	during	IN
cord-011917-6u0t4hy8	364	59	Lethal	Lethal	NNP
cord-011917-6u0t4hy8	364	60	H5N1	H5N1	NNP
cord-011917-6u0t4hy8	364	61	infection	infection	NN
cord-011917-6u0t4hy8	364	62	in	in	IN
cord-011917-6u0t4hy8	364	63	ferrets	ferret	NNS
cord-011917-6u0t4hy8	365	1	Modeling	model	VBG
cord-011917-6u0t4hy8	365	2	host	host	NN
cord-011917-6u0t4hy8	365	3	responses	response	NNS
cord-011917-6u0t4hy8	365	4	in	in	IN
cord-011917-6u0t4hy8	365	5	ferrets	ferret	NNS
cord-011917-6u0t4hy8	365	6	during	during	IN
cord-011917-6u0t4hy8	365	7	A	A	NNP
cord-011917-6u0t4hy8	365	8	/	/	SYM
cord-011917-6u0t4hy8	365	9	California/07/2009	california/07/2009	NN
cord-011917-6u0t4hy8	365	10	influenza	influenza	NN
cord-011917-6u0t4hy8	365	11	infection	infection	NN
cord-011917-6u0t4hy8	365	12	Comparative	comparative	JJ
cord-011917-6u0t4hy8	365	13	analyses	analysis	NNS
cord-011917-6u0t4hy8	365	14	of	of	IN
cord-011917-6u0t4hy8	365	15	pandemic	pandemic	JJ
cord-011917-6u0t4hy8	365	16	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	365	17	and	and	CC
cord-011917-6u0t4hy8	365	18	seasonal	seasonal	JJ
cord-011917-6u0t4hy8	365	19	H1N1	H1N1	NNP
cord-011917-6u0t4hy8	365	20	,	,	,
cord-011917-6u0t4hy8	365	21	H3N2	H3N2	NNP
cord-011917-6u0t4hy8	365	22	,	,	,
cord-011917-6u0t4hy8	365	23	and	and	CC
cord-011917-6u0t4hy8	365	24	influenza	influenza	NN
cord-011917-6u0t4hy8	365	25	B	b	NN
cord-011917-6u0t4hy8	365	26	infections	infection	NNS
cord-011917-6u0t4hy8	365	27	depict	depict	VBP
cord-011917-6u0t4hy8	365	28	distinct	distinct	JJ
cord-011917-6u0t4hy8	365	29	clinical	clinical	JJ
cord-011917-6u0t4hy8	365	30	pictures	picture	NNS
cord-011917-6u0t4hy8	365	31	in	in	IN
cord-011917-6u0t4hy8	365	32	ferrets	ferret	NNS
cord-011917-6u0t4hy8	365	33	Cloning	clone	VBG
cord-011917-6u0t4hy8	365	34	,	,	,
cord-011917-6u0t4hy8	365	35	expression	expression	NN
cord-011917-6u0t4hy8	365	36	and	and	CC
cord-011917-6u0t4hy8	365	37	immunoassay	immunoassay	JJ
cord-011917-6u0t4hy8	365	38	detection	detection	NN
cord-011917-6u0t4hy8	365	39	of	of	IN
cord-011917-6u0t4hy8	365	40	ferret	ferret	NN
cord-011917-6u0t4hy8	365	41	IFN	IFN	NNP
cord-011917-6u0t4hy8	365	42	-	-	HYPH
cord-011917-6u0t4hy8	365	43	gamma	gamma	NNP
cord-011917-6u0t4hy8	365	44	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	365	45	vaccination	vaccination	NN
cord-011917-6u0t4hy8	365	46	accelerates	accelerate	VBZ
cord-011917-6u0t4hy8	365	47	recovery	recovery	NN
cord-011917-6u0t4hy8	365	48	of	of	IN
cord-011917-6u0t4hy8	365	49	ferrets	ferret	NNS
cord-011917-6u0t4hy8	365	50	from	from	IN
cord-011917-6u0t4hy8	365	51	lymphopenia	lymphopenia	NNP
cord-011917-6u0t4hy8	365	52	Flow	Flow	NNP
cord-011917-6u0t4hy8	365	53	Cytometric	Cytometric	NNP
cord-011917-6u0t4hy8	365	54	and	and	CC
cord-011917-6u0t4hy8	365	55	Cytokine	cytokine	JJ
cord-011917-6u0t4hy8	365	56	ELISpot	elispot	NN
cord-011917-6u0t4hy8	365	57	Approaches	approach	NNS
cord-011917-6u0t4hy8	365	58	to	to	TO
cord-011917-6u0t4hy8	365	59	Characterize	characterize	VB
cord-011917-6u0t4hy8	365	60	the	the	DT
cord-011917-6u0t4hy8	365	61	Cell	cell	NN
cord-011917-6u0t4hy8	365	62	-	-	HYPH
cord-011917-6u0t4hy8	365	63	Mediated	mediate	VBN
cord-011917-6u0t4hy8	365	64	Immune	Immune	NNP
cord-011917-6u0t4hy8	365	65	Response	response	NN
cord-011917-6u0t4hy8	365	66	in	in	IN
cord-011917-6u0t4hy8	365	67	Ferrets	ferret	NNS
cord-011917-6u0t4hy8	365	68	following	follow	VBG
cord-011917-6u0t4hy8	365	69	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	365	70	Virus	Virus	NNP
cord-011917-6u0t4hy8	365	71	Infection	infection	NN
cord-011917-6u0t4hy8	365	72	Infection	infection	NN
cord-011917-6u0t4hy8	365	73	of	of	IN
cord-011917-6u0t4hy8	365	74	Ferrets	Ferrets	NNPS
cord-011917-6u0t4hy8	365	75	with	with	IN
cord-011917-6u0t4hy8	365	76	Influenza	Influenza	NNP
cord-011917-6u0t4hy8	365	77	Virus	Virus	NNP
cord-011917-6u0t4hy8	365	78	Elicits	elicit	VBZ
cord-011917-6u0t4hy8	365	79	a	a	DT
cord-011917-6u0t4hy8	365	80	Light	Light	NNP
cord-011917-6u0t4hy8	365	81	Chain	Chain	NNP
cord-011917-6u0t4hy8	365	82	-	-	HYPH
cord-011917-6u0t4hy8	365	83	Biased	Biased	NNP
cord-011917-6u0t4hy8	365	84	Antibody	Antibody	NNP
cord-011917-6u0t4hy8	365	85	Response	response	NN
cord-011917-6u0t4hy8	365	86	against	against	IN
cord-011917-6u0t4hy8	365	87	Hemagglutinin	Hemagglutinin	NNP
cord-011917-6u0t4hy8	365	88	BALDR	BALDR	NNP
cord-011917-6u0t4hy8	365	89	:	:	:
cord-011917-6u0t4hy8	366	1	A	a	DT
cord-011917-6u0t4hy8	366	2	computational	computational	JJ
cord-011917-6u0t4hy8	366	3	pipeline	pipeline	NN
cord-011917-6u0t4hy8	366	4	for	for	IN
cord-011917-6u0t4hy8	366	5	paired	pair	VBN
cord-011917-6u0t4hy8	366	6	heavy	heavy	JJ
cord-011917-6u0t4hy8	366	7	and	and	CC
cord-011917-6u0t4hy8	366	8	light	light	JJ
cord-011917-6u0t4hy8	366	9	chain	chain	NN
cord-011917-6u0t4hy8	366	10	immunoglobulin	immunoglobulin	NN
cord-011917-6u0t4hy8	366	11	reconstruction	reconstruction	NN
cord-011917-6u0t4hy8	366	12	in	in	IN
cord-011917-6u0t4hy8	366	13	single	single	JJ
cord-011917-6u0t4hy8	366	14	-	-	HYPH
cord-011917-6u0t4hy8	366	15	cell	cell	NN
cord-011917-6u0t4hy8	366	16	RNA	RNA	NNP
cord-011917-6u0t4hy8	366	17	-	-	HYPH
cord-011917-6u0t4hy8	366	18	seq	seq	NNP
cord-011917-6u0t4hy8	366	19	data	datum	NNS
cord-011917-6u0t4hy8	367	1	The	the	DT
cord-011917-6u0t4hy8	367	2	authors	author	NNS
cord-011917-6u0t4hy8	367	3	would	would	MD
cord-011917-6u0t4hy8	367	4	like	like	VB
cord-011917-6u0t4hy8	367	5	to	to	TO
cord-011917-6u0t4hy8	367	6	acknowledge	acknowledge	VB
cord-011917-6u0t4hy8	367	7	Z.	Z.	NNP
cord-011917-6u0t4hy8	367	8	Beau	Beau	NNP
cord-011917-6u0t4hy8	367	9	Reneer	Reneer	NNP
cord-011917-6u0t4hy8	367	10	and	and	CC
cord-011917-6u0t4hy8	367	11	Ying	Ying	NNP
cord-011917-6u0t4hy8	367	12	Huang	Huang	NNP
cord-011917-6u0t4hy8	367	13	for	for	IN
cord-011917-6u0t4hy8	367	14	their	-PRON-	PRP$
cord-011917-6u0t4hy8	367	15	insightful	insightful	JJ
cord-011917-6u0t4hy8	367	16	comments	comment	NNS
cord-011917-6u0t4hy8	367	17	and	and	CC
cord-011917-6u0t4hy8	367	18	critique	critique	NN
cord-011917-6u0t4hy8	367	19	.	.	.
cord-011917-6u0t4hy8	368	1	The	the	DT
cord-011917-6u0t4hy8	368	2	authors	author	NNS
cord-011917-6u0t4hy8	368	3	declare	declare	VBP
cord-011917-6u0t4hy8	368	4	no	no	DT
cord-011917-6u0t4hy8	368	5	conflict	conflict	NN
cord-011917-6u0t4hy8	368	6	of	of	IN
cord-011917-6u0t4hy8	368	7	interest	interest	NN
cord-011917-6u0t4hy8	368	8	.	.	.