id	sid	tid	token	lemma	pos
cord-018089-m94q75xn	1	1	key	key	JJ
cord-018089-m94q75xn	1	2	:	:	:
cord-018089-m94q75xn	1	3	cord-018089-m94q75xn	cord-018089-m94q75xn	NNP
cord-018089-m94q75xn	1	4	authors	author	NNS
cord-018089-m94q75xn	1	5	:	:	:
cord-018089-m94q75xn	1	6	Mubareka	Mubareka	NNP
cord-018089-m94q75xn	1	7	,	,	,
cord-018089-m94q75xn	1	8	Samira	Samira	NNP
cord-018089-m94q75xn	1	9	;	;	:
cord-018089-m94q75xn	1	10	Palese	Palese	NNP
cord-018089-m94q75xn	1	11	,	,	,
cord-018089-m94q75xn	2	1	Peter	Peter	NNP
cord-018089-m94q75xn	2	2	title	title	NN
cord-018089-m94q75xn	2	3	:	:	:
cord-018089-m94q75xn	2	4	Influenza	Influenza	NNP
cord-018089-m94q75xn	2	5	Virus	Virus	NNP
cord-018089-m94q75xn	2	6	:	:	:
cord-018089-m94q75xn	2	7	The	the	DT
cord-018089-m94q75xn	2	8	Biology	biology	NN
cord-018089-m94q75xn	2	9	of	of	IN
cord-018089-m94q75xn	2	10	a	a	DT
cord-018089-m94q75xn	2	11	Changing	change	VBG
cord-018089-m94q75xn	2	12	Virus	Virus	NNP
cord-018089-m94q75xn	2	13	date	date	NN
cord-018089-m94q75xn	2	14	:	:	:
cord-018089-m94q75xn	2	15	2010	2010	CD
cord-018089-m94q75xn	2	16	-	-	SYM
cord-018089-m94q75xn	2	17	06	06	CD
cord-018089-m94q75xn	2	18	-	-	SYM
cord-018089-m94q75xn	2	19	18	18	CD
cord-018089-m94q75xn	2	20	journal	journal	NN
cord-018089-m94q75xn	2	21	:	:	:
cord-018089-m94q75xn	2	22	Influenza	Influenza	NNP
cord-018089-m94q75xn	2	23	Vaccines	Vaccines	NNPS
cord-018089-m94q75xn	2	24	for	for	IN
cord-018089-m94q75xn	2	25	the	the	DT
cord-018089-m94q75xn	2	26	Future	Future	NNP
cord-018089-m94q75xn	2	27	DOI	doi	NN
cord-018089-m94q75xn	2	28	:	:	:
cord-018089-m94q75xn	3	1	10.1007/978	10.1007/978	LS
cord-018089-m94q75xn	3	2	-	-	SYM
cord-018089-m94q75xn	3	3	3	3	CD
cord-018089-m94q75xn	3	4	-	-	HYPH
cord-018089-m94q75xn	3	5	0346	0346	CD
cord-018089-m94q75xn	3	6	-	-	HYPH
cord-018089-m94q75xn	3	7	0279	0279	CD
cord-018089-m94q75xn	3	8	-	-	HYPH
cord-018089-m94q75xn	3	9	2_1	2_1	CD
cord-018089-m94q75xn	3	10	sha	sha	NNP
cord-018089-m94q75xn	3	11	:	:	:
cord-018089-m94q75xn	3	12	1a3fd81e17036f30bf4c2ff020bedf44323f02f9	1a3fd81e17036f30bf4c2ff020bedf44323f02f9	CD
cord-018089-m94q75xn	3	13	doc_id	doc_id	CD
cord-018089-m94q75xn	3	14	:	:	:
cord-018089-m94q75xn	4	1	18089	18089	CD
cord-018089-m94q75xn	4	2	cord_uid	cord_uid	FW
cord-018089-m94q75xn	4	3	:	:	:
cord-018089-m94q75xn	5	1	m94q75xn	m94q75xn	NNP
cord-018089-m94q75xn	5	2	Influenza	Influenza	NNP
cord-018089-m94q75xn	5	3	viruses	virus	NNS
cord-018089-m94q75xn	5	4	are	be	VBP
cord-018089-m94q75xn	5	5	members	member	NNS
cord-018089-m94q75xn	5	6	of	of	IN
cord-018089-m94q75xn	5	7	the	the	DT
cord-018089-m94q75xn	5	8	family	family	NN
cord-018089-m94q75xn	5	9	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-018089-m94q75xn	5	10	and	and	CC
cord-018089-m94q75xn	5	11	include	include	VBP
cord-018089-m94q75xn	5	12	influenza	influenza	NN
cord-018089-m94q75xn	5	13	virus	virus	NN
cord-018089-m94q75xn	5	14	types	type	VBZ
cord-018089-m94q75xn	5	15	A	A	NNP
cord-018089-m94q75xn	5	16	,	,	,
cord-018089-m94q75xn	5	17	B	b	NN
cord-018089-m94q75xn	5	18	,	,	,
cord-018089-m94q75xn	5	19	and	and	CC
cord-018089-m94q75xn	5	20	C.	C.	NNP
cord-018089-m94q75xn	6	1	This	this	DT
cord-018089-m94q75xn	6	2	introduction	introduction	NN
cord-018089-m94q75xn	6	3	provides	provide	VBZ
cord-018089-m94q75xn	6	4	an	an	DT
cord-018089-m94q75xn	6	5	overview	overview	NN
cord-018089-m94q75xn	6	6	of	of	IN
cord-018089-m94q75xn	6	7	influenza	influenza	NN
cord-018089-m94q75xn	6	8	virus	virus	NN
cord-018089-m94q75xn	6	9	classification	classification	NN
cord-018089-m94q75xn	6	10	,	,	,
cord-018089-m94q75xn	6	11	structure	structure	NN
cord-018089-m94q75xn	6	12	,	,	,
cord-018089-m94q75xn	6	13	and	and	CC
cord-018089-m94q75xn	6	14	life	life	NN
cord-018089-m94q75xn	6	15	cycle	cycle	NN
cord-018089-m94q75xn	6	16	.	.	.
cord-018089-m94q75xn	7	1	We	-PRON-	PRP
cord-018089-m94q75xn	7	2	also	also	RB
cord-018089-m94q75xn	7	3	include	include	VBP
cord-018089-m94q75xn	7	4	a	a	DT
cord-018089-m94q75xn	7	5	brief	brief	JJ
cord-018089-m94q75xn	7	6	review	review	NN
cord-018089-m94q75xn	7	7	of	of	IN
cord-018089-m94q75xn	7	8	the	the	DT
cord-018089-m94q75xn	7	9	clinical	clinical	JJ
cord-018089-m94q75xn	7	10	manifestations	manifestation	NNS
cord-018089-m94q75xn	7	11	of	of	IN
cord-018089-m94q75xn	7	12	influenza	influenza	NN
cord-018089-m94q75xn	7	13	and	and	CC
cord-018089-m94q75xn	7	14	the	the	DT
cord-018089-m94q75xn	7	15	molecular	molecular	JJ
cord-018089-m94q75xn	7	16	determinants	determinant	NNS
cord-018089-m94q75xn	7	17	for	for	IN
cord-018089-m94q75xn	7	18	virulence	virulence	NN
cord-018089-m94q75xn	7	19	.	.	.
cord-018089-m94q75xn	8	1	The	the	DT
cord-018089-m94q75xn	8	2	genetic	genetic	JJ
cord-018089-m94q75xn	8	3	diversity	diversity	NN
cord-018089-m94q75xn	8	4	of	of	IN
cord-018089-m94q75xn	8	5	influenza	influenza	NN
cord-018089-m94q75xn	8	6	A	a	DT
cord-018089-m94q75xn	8	7	viruses	virus	NNS
cord-018089-m94q75xn	8	8	and	and	CC
cord-018089-m94q75xn	8	9	their	-PRON-	PRP$
cord-018089-m94q75xn	8	10	capability	capability	NN
cord-018089-m94q75xn	8	11	to	to	TO
cord-018089-m94q75xn	8	12	successfully	successfully	RB
cord-018089-m94q75xn	8	13	infect	infect	VB
cord-018089-m94q75xn	8	14	an	an	DT
cord-018089-m94q75xn	8	15	array	array	NN
cord-018089-m94q75xn	8	16	of	of	IN
cord-018089-m94q75xn	8	17	hosts	host	NNS
cord-018089-m94q75xn	8	18	,	,	,
cord-018089-m94q75xn	8	19	including	include	VBG
cord-018089-m94q75xn	8	20	avian	avian	JJ
cord-018089-m94q75xn	8	21	and	and	CC
cord-018089-m94q75xn	8	22	mammalian	mammalian	JJ
cord-018089-m94q75xn	8	23	species	specie	NNS
cord-018089-m94q75xn	8	24	,	,	,
cord-018089-m94q75xn	8	25	are	be	VBP
cord-018089-m94q75xn	8	26	highlighted	highlight	VBN
cord-018089-m94q75xn	8	27	in	in	IN
cord-018089-m94q75xn	8	28	a	a	DT
cord-018089-m94q75xn	8	29	discussion	discussion	NN
cord-018089-m94q75xn	8	30	about	about	IN
cord-018089-m94q75xn	8	31	host	host	NN
cord-018089-m94q75xn	8	32	range	range	NN
cord-018089-m94q75xn	8	33	and	and	CC
cord-018089-m94q75xn	8	34	evolution	evolution	NN
cord-018089-m94q75xn	8	35	.	.	.
cord-018089-m94q75xn	9	1	The	the	DT
cord-018089-m94q75xn	9	2	importance	importance	NN
cord-018089-m94q75xn	9	3	of	of	IN
cord-018089-m94q75xn	9	4	viral	viral	JJ
cord-018089-m94q75xn	9	5	receptor	receptor	NN
cord-018089-m94q75xn	9	6	-	-	HYPH
cord-018089-m94q75xn	9	7	binding	bind	VBG
cord-018089-m94q75xn	9	8	hemagglutinins	hemagglutinin	NNS
cord-018089-m94q75xn	9	9	and	and	CC
cord-018089-m94q75xn	9	10	host	host	NN
cord-018089-m94q75xn	9	11	sialic	sialic	NN
cord-018089-m94q75xn	9	12	acid	acid	NN
cord-018089-m94q75xn	9	13	distribution	distribution	NN
cord-018089-m94q75xn	9	14	in	in	IN
cord-018089-m94q75xn	9	15	species	species	NN
cord-018089-m94q75xn	9	16	-	-	HYPH
cord-018089-m94q75xn	9	17	restricted	restrict	VBN
cord-018089-m94q75xn	9	18	binding	binding	NN
cord-018089-m94q75xn	9	19	of	of	IN
cord-018089-m94q75xn	9	20	viruses	virus	NNS
cord-018089-m94q75xn	9	21	is	be	VBZ
cord-018089-m94q75xn	9	22	underscored	underscore	VBN
cord-018089-m94q75xn	9	23	.	.	.
cord-018089-m94q75xn	10	1	Finally	finally	RB
cord-018089-m94q75xn	10	2	,	,	,
cord-018089-m94q75xn	10	3	recent	recent	JJ
cord-018089-m94q75xn	10	4	advances	advance	NNS
cord-018089-m94q75xn	10	5	in	in	IN
cord-018089-m94q75xn	10	6	our	-PRON-	PRP$
cord-018089-m94q75xn	10	7	understanding	understanding	NN
cord-018089-m94q75xn	10	8	of	of	IN
cord-018089-m94q75xn	10	9	the	the	DT
cord-018089-m94q75xn	10	10	seasonality	seasonality	NN
cord-018089-m94q75xn	10	11	and	and	CC
cord-018089-m94q75xn	10	12	transmission	transmission	NN
cord-018089-m94q75xn	10	13	of	of	IN
cord-018089-m94q75xn	10	14	influenza	influenza	NN
cord-018089-m94q75xn	10	15	viruses	virus	NNS
cord-018089-m94q75xn	10	16	are	be	VBP
cord-018089-m94q75xn	10	17	described	describe	VBN
cord-018089-m94q75xn	10	18	,	,	,
cord-018089-m94q75xn	10	19	and	and	CC
cord-018089-m94q75xn	10	20	their	-PRON-	PRP$
cord-018089-m94q75xn	10	21	importance	importance	NN
cord-018089-m94q75xn	10	22	for	for	IN
cord-018089-m94q75xn	10	23	the	the	DT
cord-018089-m94q75xn	10	24	control	control	NN
cord-018089-m94q75xn	10	25	of	of	IN
cord-018089-m94q75xn	10	26	the	the	DT
cord-018089-m94q75xn	10	27	spread	spread	NN
cord-018089-m94q75xn	10	28	of	of	IN
cord-018089-m94q75xn	10	29	these	these	DT
cord-018089-m94q75xn	10	30	viruses	virus	NNS
cord-018089-m94q75xn	10	31	is	be	VBZ
cord-018089-m94q75xn	10	32	discussed	discuss	VBN
cord-018089-m94q75xn	10	33	.	.	.
cord-018089-m94q75xn	11	1	H1N1	H1N1	NNP
cord-018089-m94q75xn	11	2	influenza	influenza	NN
cord-018089-m94q75xn	11	3	virus	virus	NN
cord-018089-m94q75xn	11	4	arose	arise	VBD
cord-018089-m94q75xn	11	5	from	from	IN
cord-018089-m94q75xn	11	6	an	an	DT
cord-018089-m94q75xn	11	7	unpredicted	unpredicted	JJ
cord-018089-m94q75xn	11	8	source	source	NN
cord-018089-m94q75xn	11	9	;	;	:
cord-018089-m94q75xn	11	10	precursors	precursor	NNS
cord-018089-m94q75xn	11	11	of	of	IN
cord-018089-m94q75xn	11	12	the	the	DT
cord-018089-m94q75xn	11	13	pandemic	pandemic	NN
cord-018089-m94q75xn	11	14	influenza	influenza	NN
cord-018089-m94q75xn	11	15	A	A	NNP
cord-018089-m94q75xn	11	16	(	(	-LRB-
cord-018089-m94q75xn	11	17	H1N1	H1N1	NNP
cord-018089-m94q75xn	11	18	)	)	-RRB-
cord-018089-m94q75xn	11	19	2009	2009	CD
cord-018089-m94q75xn	11	20	virus	virus	NN
cord-018089-m94q75xn	11	21	have	have	VBP
cord-018089-m94q75xn	11	22	been	be	VBN
cord-018089-m94q75xn	11	23	circulating	circulate	VBG
cord-018089-m94q75xn	11	24	among	among	IN
cord-018089-m94q75xn	11	25	pigs	pig	NNS
cord-018089-m94q75xn	11	26	for	for	IN
cord-018089-m94q75xn	11	27	over	over	IN
cord-018089-m94q75xn	11	28	a	a	DT
cord-018089-m94q75xn	11	29	decade	decade	NN
cord-018089-m94q75xn	11	30	[	[	-LRB-
cord-018089-m94q75xn	11	31	1	1	CD
cord-018089-m94q75xn	11	32	,	,	,
cord-018089-m94q75xn	11	33	2	2	CD
cord-018089-m94q75xn	11	34	]	]	-RRB-
cord-018089-m94q75xn	11	35	.	.	.
cord-018089-m94q75xn	12	1	Additional	additional	JJ
cord-018089-m94q75xn	12	2	reassortment	reassortment	NN
cord-018089-m94q75xn	12	3	events	event	NNS
cord-018089-m94q75xn	12	4	have	have	VBP
cord-018089-m94q75xn	12	5	led	lead	VBN
cord-018089-m94q75xn	12	6	to	to	IN
cord-018089-m94q75xn	12	7	the	the	DT
cord-018089-m94q75xn	12	8	current	current	JJ
cord-018089-m94q75xn	12	9	pandemic	pandemic	NN
cord-018089-m94q75xn	12	10	influenza	influenza	NN
cord-018089-m94q75xn	12	11	A	A	NNP
cord-018089-m94q75xn	12	12	(	(	-LRB-
cord-018089-m94q75xn	12	13	H1N1	H1N1	NNP
cord-018089-m94q75xn	12	14	)	)	-RRB-
cord-018089-m94q75xn	12	15	2009	2009	CD
cord-018089-m94q75xn	12	16	virus	virus	NN
cord-018089-m94q75xn	12	17	.	.	.
cord-018089-m94q75xn	13	1	Features	feature	NNS
cord-018089-m94q75xn	13	2	observed	observe	VBN
cord-018089-m94q75xn	13	3	in	in	IN
cord-018089-m94q75xn	13	4	past	past	JJ
cord-018089-m94q75xn	13	5	pandemics	pandemic	NNS
cord-018089-m94q75xn	13	6	,	,	,
cord-018089-m94q75xn	13	7	including	include	VBG
cord-018089-m94q75xn	13	8	atypical	atypical	JJ
cord-018089-m94q75xn	13	9	seasonality	seasonality	NN
cord-018089-m94q75xn	13	10	and	and	CC
cord-018089-m94q75xn	13	11	shifting	shifting	NN
cord-018089-m94q75xn	13	12	of	of	IN
cord-018089-m94q75xn	13	13	the	the	DT
cord-018089-m94q75xn	13	14	burden	burden	NN
cord-018089-m94q75xn	13	15	of	of	IN
cord-018089-m94q75xn	13	16	disease	disease	NN
cord-018089-m94q75xn	13	17	to	to	IN
cord-018089-m94q75xn	13	18	younger	young	JJR
cord-018089-m94q75xn	13	19	populations	population	NNS
cord-018089-m94q75xn	13	20	,	,	,
cord-018089-m94q75xn	13	21	are	be	VBP
cord-018089-m94q75xn	13	22	evident	evident	JJ
cord-018089-m94q75xn	13	23	during	during	IN
cord-018089-m94q75xn	13	24	the	the	DT
cord-018089-m94q75xn	13	25	influenza	influenza	NN
cord-018089-m94q75xn	13	26	pandemic	pandemic	NN
cord-018089-m94q75xn	13	27	of	of	IN
cord-018089-m94q75xn	13	28	2009	2009	CD
cord-018089-m94q75xn	13	29	.	.	.
cord-018089-m94q75xn	14	1	Our	-PRON-	PRP$
cord-018089-m94q75xn	14	2	understanding	understanding	NN
cord-018089-m94q75xn	14	3	of	of	IN
cord-018089-m94q75xn	14	4	the	the	DT
cord-018089-m94q75xn	14	5	biology	biology	NN
cord-018089-m94q75xn	14	6	of	of	IN
cord-018089-m94q75xn	14	7	influenza	influenza	NN
cord-018089-m94q75xn	14	8	virus	virus	NN
cord-018089-m94q75xn	14	9	and	and	CC
cord-018089-m94q75xn	14	10	its	-PRON-	PRP$
cord-018089-m94q75xn	14	11	effect	effect	NN
cord-018089-m94q75xn	14	12	on	on	IN
cord-018089-m94q75xn	14	13	the	the	DT
cord-018089-m94q75xn	14	14	host	host	NN
cord-018089-m94q75xn	14	15	has	have	VBZ
cord-018089-m94q75xn	14	16	advanced	advance	VBN
cord-018089-m94q75xn	14	17	considerably	considerably	RB
cord-018089-m94q75xn	14	18	in	in	IN
cord-018089-m94q75xn	14	19	recent	recent	JJ
cord-018089-m94q75xn	14	20	decades	decade	NNS
cord-018089-m94q75xn	14	21	.	.	.
cord-018089-m94q75xn	15	1	Recent	recent	JJ
cord-018089-m94q75xn	15	2	events	event	NNS
cord-018089-m94q75xn	15	3	in	in	IN
cord-018089-m94q75xn	15	4	influenza	influenza	NN
cord-018089-m94q75xn	15	5	virus	virus	NN
cord-018089-m94q75xn	15	6	research	research	NN
cord-018089-m94q75xn	15	7	have	have	VBP
cord-018089-m94q75xn	15	8	contributed	contribute	VBN
cord-018089-m94q75xn	15	9	to	to	IN
cord-018089-m94q75xn	15	10	this	this	DT
cord-018089-m94q75xn	15	11	progress	progress	NN
cord-018089-m94q75xn	15	12	[	[	-LRB-
cord-018089-m94q75xn	15	13	3	3	CD
cord-018089-m94q75xn	15	14	]	]	-RRB-
cord-018089-m94q75xn	15	15	.	.	.
cord-018089-m94q75xn	16	1	These	these	DT
cord-018089-m94q75xn	16	2	include	include	VBP
cord-018089-m94q75xn	16	3	the	the	DT
cord-018089-m94q75xn	16	4	development	development	NN
cord-018089-m94q75xn	16	5	of	of	IN
cord-018089-m94q75xn	16	6	plasmidbased	plasmidbased	NNP
cord-018089-m94q75xn	16	7	reverse	reverse	NNP
cord-018089-m94q75xn	16	8	genetics	genetics	NN
cord-018089-m94q75xn	16	9	systems	system	NNS
cord-018089-m94q75xn	16	10	[	[	-LRB-
cord-018089-m94q75xn	16	11	4	4	CD
cord-018089-m94q75xn	16	12	,	,	,
cord-018089-m94q75xn	16	13	5	5	CD
cord-018089-m94q75xn	16	14	]	]	-RRB-
cord-018089-m94q75xn	16	15	,	,	,
cord-018089-m94q75xn	16	16	the	the	DT
cord-018089-m94q75xn	16	17	generation	generation	NN
cord-018089-m94q75xn	16	18	of	of	IN
cord-018089-m94q75xn	16	19	the	the	DT
cord-018089-m94q75xn	16	20	1918	1918	CD
cord-018089-m94q75xn	16	21	pandemic	pandemic	NN
cord-018089-m94q75xn	16	22	H1N1	H1N1	NNP
cord-018089-m94q75xn	16	23	influenza	influenza	NN
cord-018089-m94q75xn	16	24	virus	virus	NN
cord-018089-m94q75xn	16	25	[	[	-LRB-
cord-018089-m94q75xn	16	26	6	6	CD
cord-018089-m94q75xn	16	27	]	]	-RRB-
cord-018089-m94q75xn	16	28	,	,	,
cord-018089-m94q75xn	16	29	improved	improve	VBD
cord-018089-m94q75xn	16	30	access	access	NN
cord-018089-m94q75xn	16	31	to	to	IN
cord-018089-m94q75xn	16	32	biosafety	biosafety	NN
cord-018089-m94q75xn	16	33	level	level	NN
cord-018089-m94q75xn	16	34	3	3	CD
cord-018089-m94q75xn	16	35	facilities	facility	NNS
cord-018089-m94q75xn	16	36	,	,	,
cord-018089-m94q75xn	16	37	the	the	DT
cord-018089-m94q75xn	16	38	establishment	establishment	NN
cord-018089-m94q75xn	16	39	of	of	IN
cord-018089-m94q75xn	16	40	international	international	JJ
cord-018089-m94q75xn	16	41	influenza	influenza	NN
cord-018089-m94q75xn	16	42	virus	virus	NN
cord-018089-m94q75xn	16	43	sequence	sequence	NN
cord-018089-m94q75xn	16	44	databases	database	NNS
cord-018089-m94q75xn	16	45	,	,	,
cord-018089-m94q75xn	16	46	and	and	CC
cord-018089-m94q75xn	16	47	bioinformatics	bioinformatic	NNS
cord-018089-m94q75xn	16	48	[	[	-LRB-
cord-018089-m94q75xn	16	49	7	7	CD
cord-018089-m94q75xn	16	50	,	,	,
cord-018089-m94q75xn	16	51	8	8	CD
cord-018089-m94q75xn	16	52	]	]	-RRB-
cord-018089-m94q75xn	16	53	.	.	.
cord-018089-m94q75xn	17	1	Advances	advance	NNS
cord-018089-m94q75xn	17	2	have	have	VBP
cord-018089-m94q75xn	17	3	also	also	RB
cord-018089-m94q75xn	17	4	led	lead	VBN
cord-018089-m94q75xn	17	5	to	to	IN
cord-018089-m94q75xn	17	6	the	the	DT
cord-018089-m94q75xn	17	7	production	production	NN
cord-018089-m94q75xn	17	8	of	of	IN
cord-018089-m94q75xn	17	9	FDA	FDA	NNP
cord-018089-m94q75xn	17	10	-	-	HYPH
cord-018089-m94q75xn	17	11	approved	approve	VBN
cord-018089-m94q75xn	17	12	antivirals	antiviral	NNS
cord-018089-m94q75xn	17	13	for	for	IN
cord-018089-m94q75xn	17	14	influenza	influenza	NN
cord-018089-m94q75xn	17	15	,	,	,
cord-018089-m94q75xn	17	16	and	and	CC
cord-018089-m94q75xn	17	17	a	a	DT
cord-018089-m94q75xn	17	18	heightened	heightened	JJ
cord-018089-m94q75xn	17	19	understanding	understanding	NN
cord-018089-m94q75xn	17	20	of	of	IN
cord-018089-m94q75xn	17	21	host	host	NN
cord-018089-m94q75xn	17	22	-	-	HYPH
cord-018089-m94q75xn	17	23	virus	virus	NN
cord-018089-m94q75xn	17	24	interactions	interaction	NNS
cord-018089-m94q75xn	17	25	resulted	result	VBD
cord-018089-m94q75xn	17	26	in	in	IN
cord-018089-m94q75xn	17	27	the	the	DT
cord-018089-m94q75xn	17	28	exploration	exploration	NN
cord-018089-m94q75xn	17	29	of	of	IN
cord-018089-m94q75xn	17	30	novel	novel	JJ
cord-018089-m94q75xn	17	31	therapies	therapy	NNS
cord-018089-m94q75xn	17	32	including	include	VBG
cord-018089-m94q75xn	17	33	immunodulatory	immunodulatory	JJ
cord-018089-m94q75xn	17	34	approaches	approach	NNS
cord-018089-m94q75xn	17	35	[	[	-LRB-
cord-018089-m94q75xn	17	36	9	9	CD
cord-018089-m94q75xn	17	37	]	]	-RRB-
cord-018089-m94q75xn	17	38	.	.	.
cord-018089-m94q75xn	18	1	New	new	JJ
cord-018089-m94q75xn	18	2	vaccine	vaccine	NN
cord-018089-m94q75xn	18	3	technologies	technology	NNS
cord-018089-m94q75xn	18	4	such	such	JJ
cord-018089-m94q75xn	18	5	as	as	IN
cord-018089-m94q75xn	18	6	the	the	DT
cord-018089-m94q75xn	18	7	use	use	NN
cord-018089-m94q75xn	18	8	of	of	IN
cord-018089-m94q75xn	18	9	live	live	RB
cord-018089-m94q75xn	18	10	-	-	HYPH
cord-018089-m94q75xn	18	11	attenuated	attenuate	VBN
cord-018089-m94q75xn	18	12	vaccines	vaccine	NNS
cord-018089-m94q75xn	18	13	[	[	-LRB-
cord-018089-m94q75xn	18	14	10	10	CD
cord-018089-m94q75xn	18	15	]	]	-RRB-
cord-018089-m94q75xn	18	16	[	[	-LRB-
cord-018089-m94q75xn	18	17	11	11	CD
cord-018089-m94q75xn	18	18	]	]	-RRB-
cord-018089-m94q75xn	18	19	[	[	-LRB-
cord-018089-m94q75xn	18	20	12	12	CD
cord-018089-m94q75xn	18	21	]	]	-RRB-
cord-018089-m94q75xn	18	22	[	[	-LRB-
cord-018089-m94q75xn	18	23	13	13	CD
cord-018089-m94q75xn	18	24	]	]	-RRB-
cord-018089-m94q75xn	18	25	and	and	CC
cord-018089-m94q75xn	18	26	the	the	DT
cord-018089-m94q75xn	18	27	development	development	NN
cord-018089-m94q75xn	18	28	of	of	IN
cord-018089-m94q75xn	18	29	novel	novel	JJ
cord-018089-m94q75xn	18	30	vaccine	vaccine	NN
cord-018089-m94q75xn	18	31	production	production	NN
cord-018089-m94q75xn	18	32	methods	method	NNS
cord-018089-m94q75xn	18	33	,	,	,
cord-018089-m94q75xn	18	34	including	include	VBG
cord-018089-m94q75xn	18	35	cell	cell	NN
cord-018089-m94q75xn	18	36	culture	culture	NN
cord-018089-m94q75xn	18	37	-	-	HYPH
cord-018089-m94q75xn	18	38	based	base	VBN
cord-018089-m94q75xn	18	39	approaches	approach	NNS
cord-018089-m94q75xn	18	40	,	,	,
cord-018089-m94q75xn	18	41	are	be	VBP
cord-018089-m94q75xn	18	42	the	the	DT
cord-018089-m94q75xn	18	43	benefits	benefit	NNS
cord-018089-m94q75xn	18	44	of	of	IN
cord-018089-m94q75xn	18	45	scientific	scientific	JJ
cord-018089-m94q75xn	18	46	progress	progress	NN
cord-018089-m94q75xn	18	47	.	.	.
cord-018089-m94q75xn	19	1	Continued	continue	VBN
cord-018089-m94q75xn	19	2	acceleration	acceleration	NN
cord-018089-m94q75xn	19	3	of	of	IN
cord-018089-m94q75xn	19	4	influenza	influenza	NN
cord-018089-m94q75xn	19	5	virus	virus	NN
cord-018089-m94q75xn	19	6	research	research	NN
cord-018089-m94q75xn	19	7	has	have	VBZ
cord-018089-m94q75xn	19	8	direct	direct	JJ
cord-018089-m94q75xn	19	9	implications	implication	NNS
cord-018089-m94q75xn	19	10	for	for	IN
cord-018089-m94q75xn	19	11	the	the	DT
cord-018089-m94q75xn	19	12	development	development	NN
cord-018089-m94q75xn	19	13	of	of	IN
cord-018089-m94q75xn	19	14	improved	improved	JJ
cord-018089-m94q75xn	19	15	vaccines	vaccine	NNS
cord-018089-m94q75xn	19	16	,	,	,
cord-018089-m94q75xn	19	17	infection	infection	NN
cord-018089-m94q75xn	19	18	control	control	NN
cord-018089-m94q75xn	19	19	,	,	,
cord-018089-m94q75xn	19	20	and	and	CC
cord-018089-m94q75xn	19	21	clinical	clinical	JJ
cord-018089-m94q75xn	19	22	management	management	NN
cord-018089-m94q75xn	19	23	during	during	IN
cord-018089-m94q75xn	19	24	pandemic	pandemic	NN
cord-018089-m94q75xn	19	25	and	and	CC
cord-018089-m94q75xn	19	26	interpandemic	interpandemic	JJ
cord-018089-m94q75xn	19	27	periods	period	NNS
cord-018089-m94q75xn	19	28	.	.	.
cord-018089-m94q75xn	20	1	Influenza	influenza	NN
cord-018089-m94q75xn	20	2	viruses	virus	NNS
cord-018089-m94q75xn	20	3	are	be	VBP
cord-018089-m94q75xn	20	4	members	member	NNS
cord-018089-m94q75xn	20	5	of	of	IN
cord-018089-m94q75xn	20	6	the	the	DT
cord-018089-m94q75xn	20	7	family	family	NN
cord-018089-m94q75xn	20	8	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-018089-m94q75xn	20	9	and	and	CC
cord-018089-m94q75xn	20	10	include	include	VBP
cord-018089-m94q75xn	20	11	influenza	influenza	NN
cord-018089-m94q75xn	20	12	virus	virus	NN
cord-018089-m94q75xn	20	13	types	type	VBZ
cord-018089-m94q75xn	20	14	A	A	NNP
cord-018089-m94q75xn	20	15	,	,	,
cord-018089-m94q75xn	20	16	B	b	NN
cord-018089-m94q75xn	20	17	,	,	,
cord-018089-m94q75xn	20	18	and	and	CC
cord-018089-m94q75xn	20	19	C.	C.	NNP
cord-018089-m94q75xn	20	20	Influenza	Influenza	NNP
cord-018089-m94q75xn	20	21	viruses	virus	NNS
cord-018089-m94q75xn	20	22	possess	possess	VBP
cord-018089-m94q75xn	20	23	seven	seven	CD
cord-018089-m94q75xn	20	24	(	(	-LRB-
cord-018089-m94q75xn	20	25	influenza	influenza	NN
cord-018089-m94q75xn	20	26	C	C	NNP
cord-018089-m94q75xn	20	27	)	)	-RRB-
cord-018089-m94q75xn	20	28	or	or	CC
cord-018089-m94q75xn	20	29	eight	eight	CD
cord-018089-m94q75xn	20	30	(	(	-LRB-
cord-018089-m94q75xn	20	31	influenza	influenza	NN
cord-018089-m94q75xn	20	32	A	a	NN
cord-018089-m94q75xn	20	33	and	and	CC
cord-018089-m94q75xn	20	34	B	b	NN
cord-018089-m94q75xn	20	35	)	)	-RRB-
cord-018089-m94q75xn	20	36	genome	genome	NN
cord-018089-m94q75xn	20	37	segments	segment	NNS
cord-018089-m94q75xn	20	38	composed	compose	VBN
cord-018089-m94q75xn	20	39	of	of	IN
cord-018089-m94q75xn	20	40	negative	negative	JJ
cord-018089-m94q75xn	20	41	sense	sense	NN
cord-018089-m94q75xn	20	42	single	single	RB
cord-018089-m94q75xn	20	43	-	-	HYPH
cord-018089-m94q75xn	20	44	stranded	strand	VBN
cord-018089-m94q75xn	20	45	RNA	RNA	NNP
cord-018089-m94q75xn	20	46	.	.	.
cord-018089-m94q75xn	21	1	These	these	DT
cord-018089-m94q75xn	21	2	types	type	NNS
cord-018089-m94q75xn	21	3	differ	differ	VBP
cord-018089-m94q75xn	21	4	in	in	IN
cord-018089-m94q75xn	21	5	various	various	JJ
cord-018089-m94q75xn	21	6	aspects	aspect	NNS
cord-018089-m94q75xn	21	7	,	,	,
cord-018089-m94q75xn	21	8	the	the	DT
cord-018089-m94q75xn	21	9	most	most	RBS
cord-018089-m94q75xn	21	10	important	important	JJ
cord-018089-m94q75xn	21	11	of	of	IN
cord-018089-m94q75xn	21	12	which	which	WDT
cord-018089-m94q75xn	21	13	include	include	VBP
cord-018089-m94q75xn	21	14	antigenicity	antigenicity	NN
cord-018089-m94q75xn	21	15	,	,	,
cord-018089-m94q75xn	21	16	host	host	NN
cord-018089-m94q75xn	21	17	range	range	NN
cord-018089-m94q75xn	21	18	,	,	,
cord-018089-m94q75xn	21	19	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	21	20	,	,	,
cord-018089-m94q75xn	21	21	transmission	transmission	NN
cord-018089-m94q75xn	21	22	,	,	,
cord-018089-m94q75xn	21	23	and	and	CC
cord-018089-m94q75xn	21	24	seasonality	seasonality	NN
cord-018089-m94q75xn	21	25	.	.	.
cord-018089-m94q75xn	22	1	Standard	standard	JJ
cord-018089-m94q75xn	22	2	nomenclature	nomenclature	NN
cord-018089-m94q75xn	22	3	for	for	IN
cord-018089-m94q75xn	22	4	human	human	JJ
cord-018089-m94q75xn	22	5	influenza	influenza	NN
cord-018089-m94q75xn	22	6	viruses	virus	NNS
cord-018089-m94q75xn	22	7	includes	include	VBZ
cord-018089-m94q75xn	22	8	type	type	NN
cord-018089-m94q75xn	22	9	,	,	,
cord-018089-m94q75xn	22	10	geographic	geographic	JJ
cord-018089-m94q75xn	22	11	location	location	NN
cord-018089-m94q75xn	22	12	of	of	IN
cord-018089-m94q75xn	22	13	isolation	isolation	NN
cord-018089-m94q75xn	22	14	,	,	,
cord-018089-m94q75xn	22	15	isolate	isolate	VB
cord-018089-m94q75xn	22	16	number	number	NN
cord-018089-m94q75xn	22	17	,	,	,
cord-018089-m94q75xn	22	18	and	and	CC
cord-018089-m94q75xn	22	19	year	year	NN
cord-018089-m94q75xn	22	20	of	of	IN
cord-018089-m94q75xn	22	21	isolation	isolation	NN
cord-018089-m94q75xn	22	22	.	.	.
cord-018089-m94q75xn	23	1	For	for	IN
cord-018089-m94q75xn	23	2	example	example	NN
cord-018089-m94q75xn	23	3	,	,	,
cord-018089-m94q75xn	23	4	an	an	DT
cord-018089-m94q75xn	23	5	influenza	influenza	NN
cord-018089-m94q75xn	23	6	A	a	DT
cord-018089-m94q75xn	23	7	virus	virus	NN
cord-018089-m94q75xn	23	8	isolated	isolate	VBN
cord-018089-m94q75xn	23	9	in	in	IN
cord-018089-m94q75xn	23	10	Panama	Panama	NNP
cord-018089-m94q75xn	23	11	in	in	IN
cord-018089-m94q75xn	23	12	1999	1999	CD
cord-018089-m94q75xn	23	13	would	would	MD
cord-018089-m94q75xn	23	14	be	be	VB
cord-018089-m94q75xn	23	15	referred	refer	VBN
cord-018089-m94q75xn	23	16	to	to	IN
cord-018089-m94q75xn	23	17	as	as	IN
cord-018089-m94q75xn	24	1	A	a	DT
cord-018089-m94q75xn	24	2	/	/	,
cord-018089-m94q75xn	24	3	Panama/2002/1999	Panama/2002/1999	NNP
cord-018089-m94q75xn	24	4	.	.	.
cord-018089-m94q75xn	25	1	Subtypes	subtype	NNS
cord-018089-m94q75xn	25	2	of	of	IN
cord-018089-m94q75xn	25	3	influenza	influenza	NN
cord-018089-m94q75xn	25	4	A	a	DT
cord-018089-m94q75xn	25	5	viruses	virus	NNS
cord-018089-m94q75xn	25	6	are	be	VBP
cord-018089-m94q75xn	25	7	described	describe	VBN
cord-018089-m94q75xn	25	8	by	by	IN
cord-018089-m94q75xn	25	9	hemagglutinin	hemagglutinin	NNS
cord-018089-m94q75xn	25	10	(	(	-LRB-
cord-018089-m94q75xn	25	11	HA	HA	NNP
cord-018089-m94q75xn	25	12	)	)	-RRB-
cord-018089-m94q75xn	25	13	and	and	CC
cord-018089-m94q75xn	25	14	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	25	15	(	(	-LRB-
cord-018089-m94q75xn	25	16	NA	NA	NNP
cord-018089-m94q75xn	25	17	)	)	-RRB-
cord-018089-m94q75xn	25	18	designations	designation	NNS
cord-018089-m94q75xn	25	19	.	.	.
cord-018089-m94q75xn	26	1	To	to	IN
cord-018089-m94q75xn	26	2	date	date	NN
cord-018089-m94q75xn	26	3	,	,	,
cord-018089-m94q75xn	26	4	16	16	CD
cord-018089-m94q75xn	26	5	HA	HA	NNP
cord-018089-m94q75xn	26	6	and	and	CC
cord-018089-m94q75xn	26	7	9	9	CD
cord-018089-m94q75xn	26	8	NA	NA	NNP
cord-018089-m94q75xn	26	9	subtypes	subtype	NNS
cord-018089-m94q75xn	26	10	have	have	VBP
cord-018089-m94q75xn	26	11	been	be	VBN
cord-018089-m94q75xn	26	12	described	describe	VBN
cord-018089-m94q75xn	26	13	.	.	.
cord-018089-m94q75xn	27	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	27	2	A	a	DT
cord-018089-m94q75xn	27	3	viruses	virus	NNS
cord-018089-m94q75xn	27	4	are	be	VBP
cord-018089-m94q75xn	27	5	mostly	mostly	RB
cord-018089-m94q75xn	27	6	responsible	responsible	JJ
cord-018089-m94q75xn	27	7	for	for	IN
cord-018089-m94q75xn	27	8	seasonal	seasonal	JJ
cord-018089-m94q75xn	27	9	epidemics	epidemic	NNS
cord-018089-m94q75xn	27	10	,	,	,
cord-018089-m94q75xn	27	11	global	global	JJ
cord-018089-m94q75xn	27	12	pandemics	pandemic	NNS
cord-018089-m94q75xn	27	13	,	,	,
cord-018089-m94q75xn	27	14	and	and	CC
cord-018089-m94q75xn	27	15	the	the	DT
cord-018089-m94q75xn	27	16	burden	burden	NN
cord-018089-m94q75xn	27	17	of	of	IN
cord-018089-m94q75xn	27	18	disease	disease	NN
cord-018089-m94q75xn	27	19	attributable	attributable	JJ
cord-018089-m94q75xn	27	20	to	to	IN
cord-018089-m94q75xn	27	21	influenza	influenza	NN
cord-018089-m94q75xn	27	22	.	.	.
cord-018089-m94q75xn	28	1	Clinical	clinical	JJ
cord-018089-m94q75xn	28	2	disease	disease	NN
cord-018089-m94q75xn	28	3	includes	include	VBZ
cord-018089-m94q75xn	28	4	systemic	systemic	JJ
cord-018089-m94q75xn	28	5	and	and	CC
cord-018089-m94q75xn	28	6	respiratory	respiratory	JJ
cord-018089-m94q75xn	28	7	manifestations	manifestation	NNS
cord-018089-m94q75xn	28	8	,	,	,
cord-018089-m94q75xn	28	9	and	and	CC
cord-018089-m94q75xn	28	10	rarely	rarely	RB
cord-018089-m94q75xn	28	11	may	may	MD
cord-018089-m94q75xn	28	12	be	be	VB
cord-018089-m94q75xn	28	13	complicated	complicate	VBN
cord-018089-m94q75xn	28	14	by	by	IN
cord-018089-m94q75xn	28	15	central	central	JJ
cord-018089-m94q75xn	28	16	nervous	nervous	JJ
cord-018089-m94q75xn	28	17	system	system	NN
cord-018089-m94q75xn	28	18	involvement	involvement	NN
cord-018089-m94q75xn	28	19	,	,	,
cord-018089-m94q75xn	28	20	toxic	toxic	JJ
cord-018089-m94q75xn	28	21	shock	shock	NN
cord-018089-m94q75xn	28	22	,	,	,
cord-018089-m94q75xn	28	23	or	or	CC
cord-018089-m94q75xn	28	24	multiorgan	multiorgan	NN
cord-018089-m94q75xn	28	25	system	system	NN
cord-018089-m94q75xn	28	26	failure	failure	NN
cord-018089-m94q75xn	28	27	[	[	-LRB-
cord-018089-m94q75xn	28	28	14	14	CD
cord-018089-m94q75xn	28	29	,	,	,
cord-018089-m94q75xn	28	30	15	15	CD
cord-018089-m94q75xn	28	31	]	]	-RRB-
cord-018089-m94q75xn	28	32	.	.	.
cord-018089-m94q75xn	29	1	Circulating	circulate	VBG
cord-018089-m94q75xn	29	2	strains	strain	NNS
cord-018089-m94q75xn	29	3	of	of	IN
cord-018089-m94q75xn	29	4	influenza	influenza	NN
cord-018089-m94q75xn	29	5	A	a	DT
cord-018089-m94q75xn	29	6	viruses	virus	NNS
cord-018089-m94q75xn	29	7	are	be	VBP
cord-018089-m94q75xn	29	8	targets	target	NNS
cord-018089-m94q75xn	29	9	for	for	IN
cord-018089-m94q75xn	29	10	annual	annual	JJ
cord-018089-m94q75xn	29	11	vaccination	vaccination	NN
cord-018089-m94q75xn	29	12	to	to	TO
cord-018089-m94q75xn	29	13	mitigate	mitigate	VB
cord-018089-m94q75xn	29	14	morbidity	morbidity	NN
cord-018089-m94q75xn	29	15	and	and	CC
cord-018089-m94q75xn	29	16	mortality	mortality	NN
cord-018089-m94q75xn	29	17	imparted	impart	VBN
cord-018089-m94q75xn	29	18	by	by	IN
cord-018089-m94q75xn	29	19	these	these	DT
cord-018089-m94q75xn	29	20	viruses	virus	NNS
cord-018089-m94q75xn	29	21	.	.	.
cord-018089-m94q75xn	30	1	In	in	IN
cord-018089-m94q75xn	30	2	addition	addition	NN
cord-018089-m94q75xn	30	3	to	to	IN
cord-018089-m94q75xn	30	4	infecting	infect	VBG
cord-018089-m94q75xn	30	5	humans	human	NNS
cord-018089-m94q75xn	30	6	,	,	,
cord-018089-m94q75xn	30	7	influenza	influenza	VB
cord-018089-m94q75xn	30	8	A	a	DT
cord-018089-m94q75xn	30	9	viruses	virus	NNS
cord-018089-m94q75xn	30	10	circulate	circulate	VBP
cord-018089-m94q75xn	30	11	in	in	IN
cord-018089-m94q75xn	30	12	other	other	JJ
cord-018089-m94q75xn	30	13	mammals	mammal	NNS
cord-018089-m94q75xn	30	14	,	,	,
cord-018089-m94q75xn	30	15	including	include	VBG
cord-018089-m94q75xn	30	16	swine	swine	NN
cord-018089-m94q75xn	30	17	and	and	CC
cord-018089-m94q75xn	30	18	horses	horse	NNS
cord-018089-m94q75xn	30	19	.	.	.
cord-018089-m94q75xn	31	1	Waterfowl	waterfowl	NN
cord-018089-m94q75xn	31	2	harbor	harbor	VBP
cord-018089-m94q75xn	31	3	several	several	JJ
cord-018089-m94q75xn	31	4	lineages	lineage	NNS
cord-018089-m94q75xn	31	5	of	of	IN
cord-018089-m94q75xn	31	6	influenza	influenza	NN
cord-018089-m94q75xn	31	7	A	a	NN
cord-018089-m94q75xn	31	8	viruses	virus	NNS
cord-018089-m94q75xn	31	9	and	and	CC
cord-018089-m94q75xn	31	10	serve	serve	VBP
cord-018089-m94q75xn	31	11	as	as	IN
cord-018089-m94q75xn	31	12	a	a	DT
cord-018089-m94q75xn	31	13	reservoir	reservoir	NN
cord-018089-m94q75xn	31	14	.	.	.
cord-018089-m94q75xn	32	1	Transmission	transmission	NN
cord-018089-m94q75xn	32	2	among	among	IN
cord-018089-m94q75xn	32	3	wild	wild	JJ
cord-018089-m94q75xn	32	4	and	and	CC
cord-018089-m94q75xn	32	5	domestic	domestic	JJ
cord-018089-m94q75xn	32	6	fowl	fowl	NN
cord-018089-m94q75xn	32	7	and	and	CC
cord-018089-m94q75xn	32	8	mammalian	mammalian	JJ
cord-018089-m94q75xn	32	9	species	specie	NNS
cord-018089-m94q75xn	32	10	is	be	VBZ
cord-018089-m94q75xn	32	11	an	an	DT
cord-018089-m94q75xn	32	12	important	important	JJ
cord-018089-m94q75xn	32	13	characteristic	characteristic	NN
cord-018089-m94q75xn	32	14	of	of	IN
cord-018089-m94q75xn	32	15	influenza	influenza	NN
cord-018089-m94q75xn	32	16	A	A	NNP
cord-018089-m94q75xn	32	17	,	,	,
cord-018089-m94q75xn	32	18	enabling	enable	VBG
cord-018089-m94q75xn	32	19	viral	viral	JJ
cord-018089-m94q75xn	32	20	reassortment	reassortment	NN
cord-018089-m94q75xn	32	21	and	and	CC
cord-018089-m94q75xn	32	22	emergence	emergence	NN
cord-018089-m94q75xn	32	23	of	of	IN
cord-018089-m94q75xn	32	24	novel	novel	JJ
cord-018089-m94q75xn	32	25	subtypes	subtype	NNS
cord-018089-m94q75xn	32	26	in	in	IN
cord-018089-m94q75xn	32	27	susceptible	susceptible	JJ
cord-018089-m94q75xn	32	28	human	human	JJ
cord-018089-m94q75xn	32	29	populations	population	NNS
cord-018089-m94q75xn	32	30	.	.	.
cord-018089-m94q75xn	33	1	In	in	IN
cord-018089-m94q75xn	33	2	contrast	contrast	NN
cord-018089-m94q75xn	33	3	,	,	,
cord-018089-m94q75xn	33	4	influenza	influenza	NN
cord-018089-m94q75xn	33	5	B	b	NN
cord-018089-m94q75xn	33	6	virus	virus	NN
cord-018089-m94q75xn	33	7	has	have	VBZ
cord-018089-m94q75xn	33	8	a	a	DT
cord-018089-m94q75xn	33	9	restricted	restricted	JJ
cord-018089-m94q75xn	33	10	host	host	NN
cord-018089-m94q75xn	33	11	range	range	NN
cord-018089-m94q75xn	33	12	,	,	,
cord-018089-m94q75xn	33	13	circulating	circulate	VBG
cord-018089-m94q75xn	33	14	only	only	RB
cord-018089-m94q75xn	33	15	in	in	IN
cord-018089-m94q75xn	33	16	humans	human	NNS
cord-018089-m94q75xn	33	17	,	,	,
cord-018089-m94q75xn	33	18	although	although	IN
cord-018089-m94q75xn	33	19	the	the	DT
cord-018089-m94q75xn	33	20	virus	virus	NN
cord-018089-m94q75xn	33	21	has	have	VBZ
cord-018089-m94q75xn	33	22	been	be	VBN
cord-018089-m94q75xn	33	23	isolated	isolate	VBN
cord-018089-m94q75xn	33	24	in	in	IN
cord-018089-m94q75xn	33	25	seals	seal	NNS
cord-018089-m94q75xn	33	26	[	[	-LRB-
cord-018089-m94q75xn	33	27	16	16	CD
cord-018089-m94q75xn	33	28	]	]	-RRB-
cord-018089-m94q75xn	33	29	.	.	.
cord-018089-m94q75xn	34	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	34	2	B	B	NNP
cord-018089-m94q75xn	34	3	virus	virus	NN
cord-018089-m94q75xn	34	4	demonstrates	demonstrate	VBZ
cord-018089-m94q75xn	34	5	seasonality	seasonality	NN
cord-018089-m94q75xn	34	6	and	and	CC
cord-018089-m94q75xn	34	7	is	be	VBZ
cord-018089-m94q75xn	34	8	responsible	responsible	JJ
cord-018089-m94q75xn	34	9	for	for	IN
cord-018089-m94q75xn	34	10	human	human	JJ
cord-018089-m94q75xn	34	11	disease	disease	NN
cord-018089-m94q75xn	34	12	,	,	,
cord-018089-m94q75xn	34	13	although	although	IN
cord-018089-m94q75xn	34	14	the	the	DT
cord-018089-m94q75xn	34	15	clinical	clinical	JJ
cord-018089-m94q75xn	34	16	manifestations	manifestation	NNS
cord-018089-m94q75xn	34	17	are	be	VBP
cord-018089-m94q75xn	34	18	generally	generally	RB
cord-018089-m94q75xn	34	19	less	less	RBR
cord-018089-m94q75xn	34	20	severe	severe	JJ
cord-018089-m94q75xn	34	21	compared	compare	VBN
cord-018089-m94q75xn	34	22	with	with	IN
cord-018089-m94q75xn	34	23	influenza	influenza	NN
cord-018089-m94q75xn	34	24	A	a	DT
cord-018089-m94q75xn	34	25	virus	virus	NN
cord-018089-m94q75xn	34	26	-	-	HYPH
cord-018089-m94q75xn	34	27	associated	associate	VBN
cord-018089-m94q75xn	34	28	illness	illness	NN
cord-018089-m94q75xn	34	29	.	.	.
cord-018089-m94q75xn	35	1	Nonetheless	nonetheless	RB
cord-018089-m94q75xn	35	2	,	,	,
cord-018089-m94q75xn	35	3	rare	rare	JJ
cord-018089-m94q75xn	35	4	cases	case	NNS
cord-018089-m94q75xn	35	5	of	of	IN
cord-018089-m94q75xn	35	6	encephalitis	encephalitis	JJ
cord-018089-m94q75xn	35	7	and	and	CC
cord-018089-m94q75xn	35	8	septic	septic	JJ
cord-018089-m94q75xn	35	9	shock	shock	NN
cord-018089-m94q75xn	35	10	have	have	VBP
cord-018089-m94q75xn	35	11	been	be	VBN
cord-018089-m94q75xn	35	12	described	describe	VBN
cord-018089-m94q75xn	35	13	in	in	IN
cord-018089-m94q75xn	35	14	children	child	NNS
cord-018089-m94q75xn	35	15	[	[	-LRB-
cord-018089-m94q75xn	35	16	17	17	CD
cord-018089-m94q75xn	35	17	,	,	,
cord-018089-m94q75xn	35	18	18	18	CD
cord-018089-m94q75xn	35	19	]	]	-RRB-
cord-018089-m94q75xn	35	20	.	.	.
cord-018089-m94q75xn	36	1	At	at	IN
cord-018089-m94q75xn	36	2	present	present	NN
cord-018089-m94q75xn	36	3	,	,	,
cord-018089-m94q75xn	36	4	the	the	DT
cord-018089-m94q75xn	36	5	two	two	CD
cord-018089-m94q75xn	36	6	major	major	JJ
cord-018089-m94q75xn	36	7	lineages	lineage	NNS
cord-018089-m94q75xn	36	8	are	be	VBP
cord-018089-m94q75xn	36	9	represented	represent	VBN
cord-018089-m94q75xn	36	10	by	by	IN
cord-018089-m94q75xn	36	11	influenza	influenza	NN
cord-018089-m94q75xn	36	12	B	b	NN
cord-018089-m94q75xn	36	13	/	/	SYM
cord-018089-m94q75xn	36	14	Victoria/2/1987	victoria/2/1987	NN
cord-018089-m94q75xn	36	15	and	and	CC
cord-018089-m94q75xn	36	16	B	B	NNP
cord-018089-m94q75xn	36	17	/	/	SYM
cord-018089-m94q75xn	36	18	Yamagata/16/1988	yamagata/16/1988	NN
cord-018089-m94q75xn	37	1	viruses	virus	NNS
cord-018089-m94q75xn	37	2	[	[	-LRB-
cord-018089-m94q75xn	37	3	19	19	CD
cord-018089-m94q75xn	37	4	]	]	-RRB-
cord-018089-m94q75xn	37	5	.	.	.
cord-018089-m94q75xn	38	1	Re	Re	NNS
cord-018089-m94q75xn	38	2	-	-	NN
cord-018089-m94q75xn	38	3	emergence	emergence	NN
cord-018089-m94q75xn	38	4	of	of	IN
cord-018089-m94q75xn	38	5	the	the	DT
cord-018089-m94q75xn	38	6	Victoria	Victoria	NNP
cord-018089-m94q75xn	38	7	lineage	lineage	NN
cord-018089-m94q75xn	38	8	after	after	IN
cord-018089-m94q75xn	38	9	a	a	DT
cord-018089-m94q75xn	38	10	decade	decade	NN
cord-018089-m94q75xn	38	11	of	of	IN
cord-018089-m94q75xn	38	12	absence	absence	NN
cord-018089-m94q75xn	38	13	was	be	VBD
cord-018089-m94q75xn	38	14	associated	associate	VBN
cord-018089-m94q75xn	38	15	with	with	IN
cord-018089-m94q75xn	38	16	an	an	DT
cord-018089-m94q75xn	38	17	outbreak	outbreak	NN
cord-018089-m94q75xn	38	18	during	during	IN
cord-018089-m94q75xn	38	19	the	the	DT
cord-018089-m94q75xn	38	20	2001	2001	CD
cord-018089-m94q75xn	38	21	-	-	SYM
cord-018089-m94q75xn	38	22	2002	2002	CD
cord-018089-m94q75xn	38	23	influenza	influenza	NN
cord-018089-m94q75xn	38	24	season	season	NN
cord-018089-m94q75xn	38	25	,	,	,
cord-018089-m94q75xn	38	26	affecting	affect	VBG
cord-018089-m94q75xn	38	27	healthy	healthy	JJ
cord-018089-m94q75xn	38	28	but	but	CC
cord-018089-m94q75xn	38	29	immunologically	immunologically	RB
cord-018089-m94q75xn	38	30	naive	naive	JJ
cord-018089-m94q75xn	38	31	children	child	NNS
cord-018089-m94q75xn	38	32	[	[	-LRB-
cord-018089-m94q75xn	38	33	20	20	CD
cord-018089-m94q75xn	38	34	]	]	-RRB-
cord-018089-m94q75xn	38	35	.	.	.
cord-018089-m94q75xn	39	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	39	2	B	B	NNP
cord-018089-m94q75xn	39	3	virus	virus	NN
cord-018089-m94q75xn	39	4	is	be	VBZ
cord-018089-m94q75xn	39	5	included	include	VBN
cord-018089-m94q75xn	39	6	in	in	IN
cord-018089-m94q75xn	39	7	inactivated	inactivated	JJ
cord-018089-m94q75xn	39	8	and	and	CC
cord-018089-m94q75xn	39	9	live	live	RB
cord-018089-m94q75xn	39	10	-	-	HYPH
cord-018089-m94q75xn	39	11	attenuated	attenuated	JJ
cord-018089-m94q75xn	39	12	annual	annual	JJ
cord-018089-m94q75xn	39	13	influenza	influenza	NN
cord-018089-m94q75xn	39	14	vaccines	vaccine	NNS
cord-018089-m94q75xn	39	15	.	.	.
cord-018089-m94q75xn	40	1	Unlike	unlike	IN
cord-018089-m94q75xn	40	2	influenza	influenza	NN
cord-018089-m94q75xn	40	3	A	a	NN
cord-018089-m94q75xn	40	4	and	and	CC
cord-018089-m94q75xn	40	5	B	b	NN
cord-018089-m94q75xn	40	6	,	,	,
cord-018089-m94q75xn	40	7	influenza	influenza	NN
cord-018089-m94q75xn	40	8	C	c	NN
cord-018089-m94q75xn	40	9	virus	virus	NN
cord-018089-m94q75xn	40	10	lacks	lack	VBZ
cord-018089-m94q75xn	40	11	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	40	12	and	and	CC
cord-018089-m94q75xn	40	13	codes	code	NNS
cord-018089-m94q75xn	40	14	for	for	IN
cord-018089-m94q75xn	40	15	a	a	DT
cord-018089-m94q75xn	40	16	single	single	JJ
cord-018089-m94q75xn	40	17	-	-	HYPH
cord-018089-m94q75xn	40	18	surface	surface	NN
cord-018089-m94q75xn	40	19	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	40	20	-	-	HYPH
cord-018089-m94q75xn	40	21	esterase	esterase	NN
cord-018089-m94q75xn	40	22	-	-	HYPH
cord-018089-m94q75xn	40	23	fusion	fusion	NN
cord-018089-m94q75xn	40	24	(	(	-LRB-
cord-018089-m94q75xn	40	25	HEF	HEF	NNP
cord-018089-m94q75xn	40	26	)	)	-RRB-
cord-018089-m94q75xn	40	27	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	40	28	.	.	.
cord-018089-m94q75xn	41	1	This	this	DT
cord-018089-m94q75xn	41	2	virus	virus	NN
cord-018089-m94q75xn	41	3	does	do	VBZ
cord-018089-m94q75xn	41	4	not	not	RB
cord-018089-m94q75xn	41	5	demonstrate	demonstrate	VB
cord-018089-m94q75xn	41	6	marked	mark	VBN
cord-018089-m94q75xn	41	7	seasonality	seasonality	NN
cord-018089-m94q75xn	41	8	and	and	CC
cord-018089-m94q75xn	41	9	is	be	VBZ
cord-018089-m94q75xn	41	10	not	not	RB
cord-018089-m94q75xn	41	11	included	include	VBN
cord-018089-m94q75xn	41	12	in	in	IN
cord-018089-m94q75xn	41	13	the	the	DT
cord-018089-m94q75xn	41	14	annual	annual	JJ
cord-018089-m94q75xn	41	15	influenza	influenza	NN
cord-018089-m94q75xn	41	16	vaccine	vaccine	NN
cord-018089-m94q75xn	41	17	,	,	,
cord-018089-m94q75xn	41	18	although	although	IN
cord-018089-m94q75xn	41	19	it	-PRON-	PRP
cord-018089-m94q75xn	41	20	has	have	VBZ
cord-018089-m94q75xn	41	21	been	be	VBN
cord-018089-m94q75xn	41	22	responsible	responsible	JJ
cord-018089-m94q75xn	41	23	for	for	IN
cord-018089-m94q75xn	41	24	occasional	occasional	JJ
cord-018089-m94q75xn	41	25	outbreaks	outbreak	NNS
cord-018089-m94q75xn	41	26	,	,	,
cord-018089-m94q75xn	41	27	predominantly	predominantly	RB
cord-018089-m94q75xn	41	28	in	in	IN
cord-018089-m94q75xn	41	29	children	child	NNS
cord-018089-m94q75xn	41	30	[	[	-LRB-
cord-018089-m94q75xn	41	31	21	21	CD
cord-018089-m94q75xn	41	32	]	]	-RRB-
cord-018089-m94q75xn	41	33	.	.	.
cord-018089-m94q75xn	42	1	Illness	illness	NN
cord-018089-m94q75xn	42	2	in	in	IN
cord-018089-m94q75xn	42	3	humans	human	NNS
cord-018089-m94q75xn	42	4	is	be	VBZ
cord-018089-m94q75xn	42	5	generally	generally	RB
cord-018089-m94q75xn	42	6	mild	mild	JJ
cord-018089-m94q75xn	42	7	and	and	CC
cord-018089-m94q75xn	42	8	consists	consist	VBZ
cord-018089-m94q75xn	42	9	of	of	IN
cord-018089-m94q75xn	42	10	an	an	DT
cord-018089-m94q75xn	42	11	upper	upper	JJ
cord-018089-m94q75xn	42	12	respiratory	respiratory	JJ
cord-018089-m94q75xn	42	13	tract	tract	NN
cord-018089-m94q75xn	42	14	infection	infection	NN
cord-018089-m94q75xn	42	15	.	.	.
cord-018089-m94q75xn	43	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	43	2	C	C	NNP
cord-018089-m94q75xn	43	3	has	have	VBZ
cord-018089-m94q75xn	43	4	also	also	RB
cord-018089-m94q75xn	43	5	been	be	VBN
cord-018089-m94q75xn	43	6	isolated	isolate	VBN
cord-018089-m94q75xn	43	7	in	in	IN
cord-018089-m94q75xn	43	8	swine	swine	NN
cord-018089-m94q75xn	43	9	,	,	,
cord-018089-m94q75xn	43	10	raising	raise	VBG
cord-018089-m94q75xn	43	11	the	the	DT
cord-018089-m94q75xn	43	12	possibility	possibility	NN
cord-018089-m94q75xn	43	13	that	that	IN
cord-018089-m94q75xn	43	14	this	this	DT
cord-018089-m94q75xn	43	15	species	specie	NNS
cord-018089-m94q75xn	43	16	may	may	MD
cord-018089-m94q75xn	43	17	serve	serve	VB
cord-018089-m94q75xn	43	18	as	as	IN
cord-018089-m94q75xn	43	19	a	a	DT
cord-018089-m94q75xn	43	20	reservoir	reservoir	NN
cord-018089-m94q75xn	43	21	[	[	-LRB-
cord-018089-m94q75xn	43	22	22	22	CD
cord-018089-m94q75xn	43	23	]	]	-RRB-
cord-018089-m94q75xn	43	24	.	.	.
cord-018089-m94q75xn	44	1	Influenza	influenza	NN
cord-018089-m94q75xn	44	2	viruses	virus	NNS
cord-018089-m94q75xn	44	3	are	be	VBP
cord-018089-m94q75xn	44	4	enveloped	envelop	VBN
cord-018089-m94q75xn	44	5	,	,	,
cord-018089-m94q75xn	44	6	deriving	derive	VBG
cord-018089-m94q75xn	44	7	the	the	DT
cord-018089-m94q75xn	44	8	lipid	lipid	NN
cord-018089-m94q75xn	44	9	bilayer	bilayer	NN
cord-018089-m94q75xn	44	10	from	from	IN
cord-018089-m94q75xn	44	11	the	the	DT
cord-018089-m94q75xn	44	12	host	host	NN
cord-018089-m94q75xn	44	13	cell	cell	NN
cord-018089-m94q75xn	44	14	membrane	membrane	NN
cord-018089-m94q75xn	44	15	during	during	IN
cord-018089-m94q75xn	44	16	the	the	DT
cord-018089-m94q75xn	44	17	process	process	NN
cord-018089-m94q75xn	44	18	of	of	IN
cord-018089-m94q75xn	44	19	budding	bud	VBG
cord-018089-m94q75xn	44	20	.	.	.
cord-018089-m94q75xn	45	1	Viral	viral	JJ
cord-018089-m94q75xn	45	2	particles	particle	NNS
cord-018089-m94q75xn	45	3	are	be	VBP
cord-018089-m94q75xn	45	4	pleomorphic	pleomorphic	JJ
cord-018089-m94q75xn	45	5	in	in	IN
cord-018089-m94q75xn	45	6	nature	nature	NN
cord-018089-m94q75xn	45	7	and	and	CC
cord-018089-m94q75xn	45	8	may	may	MD
cord-018089-m94q75xn	45	9	be	be	VB
cord-018089-m94q75xn	45	10	spherical	spherical	JJ
cord-018089-m94q75xn	45	11	or	or	CC
cord-018089-m94q75xn	45	12	filamentous	filamentous	JJ
cord-018089-m94q75xn	45	13	,	,	,
cord-018089-m94q75xn	45	14	ranging	range	VBG
cord-018089-m94q75xn	45	15	in	in	IN
cord-018089-m94q75xn	45	16	size	size	NN
cord-018089-m94q75xn	45	17	from	from	IN
cord-018089-m94q75xn	45	18	100	100	CD
cord-018089-m94q75xn	45	19	to	to	IN
cord-018089-m94q75xn	45	20	over	over	IN
cord-018089-m94q75xn	45	21	300	300	CD
cord-018089-m94q75xn	45	22	nm	nm	NN
cord-018089-m94q75xn	45	23	[	[	-LRB-
cord-018089-m94q75xn	45	24	3	3	CD
cord-018089-m94q75xn	45	25	]	]	-RRB-
cord-018089-m94q75xn	45	26	.	.	.
cord-018089-m94q75xn	46	1	Spikes	spike	NNS
cord-018089-m94q75xn	46	2	consisting	consist	VBG
cord-018089-m94q75xn	46	3	of	of	IN
cord-018089-m94q75xn	46	4	HA	HA	NNP
cord-018089-m94q75xn	46	5	and	and	CC
cord-018089-m94q75xn	46	6	NA	NA	NNP
cord-018089-m94q75xn	46	7	project	project	NN
cord-018089-m94q75xn	46	8	from	from	IN
cord-018089-m94q75xn	46	9	the	the	DT
cord-018089-m94q75xn	46	10	surface	surface	NN
cord-018089-m94q75xn	46	11	of	of	IN
cord-018089-m94q75xn	46	12	virions	virion	NNS
cord-018089-m94q75xn	46	13	at	at	IN
cord-018089-m94q75xn	46	14	a	a	DT
cord-018089-m94q75xn	46	15	ratio	ratio	NN
cord-018089-m94q75xn	46	16	of	of	IN
cord-018089-m94q75xn	46	17	roughly	roughly	RB
cord-018089-m94q75xn	46	18	4:1	4:1	CD
cord-018089-m94q75xn	46	19	in	in	IN
cord-018089-m94q75xn	46	20	influenza	influenza	NN
cord-018089-m94q75xn	46	21	A	a	DT
cord-018089-m94q75xn	46	22	viruses	virus	NNS
cord-018089-m94q75xn	47	1	(	(	-LRB-
cord-018089-m94q75xn	47	2	Fig	Fig	NNP
cord-018089-m94q75xn	47	3	.	.	.
cord-018089-m94q75xn	47	4	1	1	CD
cord-018089-m94q75xn	47	5	)	)	-RRB-
cord-018089-m94q75xn	47	6	[	[	-LRB-
cord-018089-m94q75xn	47	7	3	3	CD
cord-018089-m94q75xn	47	8	]	]	-RRB-
cord-018089-m94q75xn	47	9	.	.	.
cord-018089-m94q75xn	48	1	The	the	DT
cord-018089-m94q75xn	48	2	viral	viral	JJ
cord-018089-m94q75xn	48	3	envelope	envelope	NN
cord-018089-m94q75xn	48	4	is	be	VBZ
cord-018089-m94q75xn	48	5	also	also	RB
cord-018089-m94q75xn	48	6	associated	associate	VBN
cord-018089-m94q75xn	48	7	with	with	IN
cord-018089-m94q75xn	48	8	the	the	DT
cord-018089-m94q75xn	48	9	matrix	matrix	NN
cord-018089-m94q75xn	48	10	(	(	-LRB-
cord-018089-m94q75xn	48	11	M2	M2	NNP
cord-018089-m94q75xn	48	12	)	)	-RRB-
cord-018089-m94q75xn	48	13	protein	protein	NN
cord-018089-m94q75xn	48	14	which	which	WDT
cord-018089-m94q75xn	48	15	forms	form	VBZ
cord-018089-m94q75xn	48	16	a	a	DT
cord-018089-m94q75xn	48	17	tetrameric	tetrameric	JJ
cord-018089-m94q75xn	48	18	ion	ion	NN
cord-018089-m94q75xn	48	19	channel	channel	NN
cord-018089-m94q75xn	48	20	.	.	.
cord-018089-m94q75xn	49	1	The	the	DT
cord-018089-m94q75xn	49	2	polymerase	polymerase	NN
cord-018089-m94q75xn	49	3	proteins	protein	VBZ
cord-018089-m94q75xn	49	4	PB1	pb1	NN
cord-018089-m94q75xn	49	5	,	,	,
cord-018089-m94q75xn	49	6	PB2	PB2	NNP
cord-018089-m94q75xn	49	7	,	,	,
cord-018089-m94q75xn	49	8	and	and	CC
cord-018089-m94q75xn	49	9	PA	PA	NNP
cord-018089-m94q75xn	49	10	,	,	,
cord-018089-m94q75xn	49	11	the	the	DT
cord-018089-m94q75xn	49	12	nucleoprotein	nucleoprotein	NNP
cord-018089-m94q75xn	49	13	(	(	-LRB-
cord-018089-m94q75xn	49	14	NP	NP	NNP
cord-018089-m94q75xn	49	15	)	)	-RRB-
cord-018089-m94q75xn	49	16	,	,	,
cord-018089-m94q75xn	49	17	and	and	CC
cord-018089-m94q75xn	49	18	the	the	DT
cord-018089-m94q75xn	49	19	virion	virion	NN
cord-018089-m94q75xn	49	20	RNA	RNA	NNP
cord-018089-m94q75xn	49	21	comprise	comprise	VBP
cord-018089-m94q75xn	49	22	the	the	DT
cord-018089-m94q75xn	49	23	ribonucleoprotein	ribonucleoprotein	NN
cord-018089-m94q75xn	49	24	(	(	-LRB-
cord-018089-m94q75xn	49	25	RNP	RNP	NNP
cord-018089-m94q75xn	49	26	)	)	-RRB-
cord-018089-m94q75xn	49	27	complex	complex	NN
cord-018089-m94q75xn	49	28	.	.	.
cord-018089-m94q75xn	50	1	This	this	DT
cord-018089-m94q75xn	50	2	complex	complex	NN
cord-018089-m94q75xn	50	3	is	be	VBZ
cord-018089-m94q75xn	50	4	present	present	JJ
cord-018089-m94q75xn	50	5	in	in	IN
cord-018089-m94q75xn	50	6	the	the	DT
cord-018089-m94q75xn	50	7	core	core	NN
cord-018089-m94q75xn	50	8	of	of	IN
cord-018089-m94q75xn	50	9	virions	virion	NNS
cord-018089-m94q75xn	50	10	,	,	,
cord-018089-m94q75xn	50	11	which	which	WDT
cord-018089-m94q75xn	50	12	also	also	RB
cord-018089-m94q75xn	50	13	includes	include	VBZ
cord-018089-m94q75xn	50	14	the	the	DT
cord-018089-m94q75xn	50	15	nuclear	nuclear	JJ
cord-018089-m94q75xn	50	16	export	export	NN
cord-018089-m94q75xn	50	17	and	and	CC
cord-018089-m94q75xn	50	18	nonstructural	nonstructural	JJ
cord-018089-m94q75xn	50	19	protein	protein	NN
cord-018089-m94q75xn	50	20	(	(	-LRB-
cord-018089-m94q75xn	50	21	NEP	NEP	NNP
cord-018089-m94q75xn	50	22	/	/	SYM
cord-018089-m94q75xn	50	23	NS1	ns1	NN
cord-018089-m94q75xn	50	24	)	)	-RRB-
cord-018089-m94q75xn	50	25	.	.	.
cord-018089-m94q75xn	51	1	Influenza	influenza	NN
cord-018089-m94q75xn	51	2	virus	virus	NN
cord-018089-m94q75xn	51	3	genes	gene	NNS
cord-018089-m94q75xn	51	4	,	,	,
cord-018089-m94q75xn	51	5	gene	gene	NN
cord-018089-m94q75xn	51	6	products	product	NNS
cord-018089-m94q75xn	51	7	,	,	,
cord-018089-m94q75xn	51	8	and	and	CC
cord-018089-m94q75xn	51	9	primary	primary	JJ
cord-018089-m94q75xn	51	10	functions	function	NNS
cord-018089-m94q75xn	51	11	are	be	VBP
cord-018089-m94q75xn	51	12	summarized	summarize	VBN
cord-018089-m94q75xn	51	13	in	in	IN
cord-018089-m94q75xn	51	14	Table	Table	NNP
cord-018089-m94q75xn	51	15	1	1	CD
cord-018089-m94q75xn	51	16	.	.	.
cord-018089-m94q75xn	52	1	In	in	IN
cord-018089-m94q75xn	52	2	humans	human	NNS
cord-018089-m94q75xn	52	3	,	,	,
cord-018089-m94q75xn	52	4	influenza	influenza	NN
cord-018089-m94q75xn	52	5	viruses	virus	NNS
cord-018089-m94q75xn	52	6	are	be	VBP
cord-018089-m94q75xn	52	7	transmitted	transmit	VBN
cord-018089-m94q75xn	52	8	by	by	IN
cord-018089-m94q75xn	52	9	the	the	DT
cord-018089-m94q75xn	52	10	respiratory	respiratory	JJ
cord-018089-m94q75xn	52	11	route	route	NN
cord-018089-m94q75xn	52	12	.	.	.
cord-018089-m94q75xn	53	1	Host	host	JJ
cord-018089-m94q75xn	53	2	cellular	cellular	JJ
cord-018089-m94q75xn	53	3	receptors	receptor	NNS
cord-018089-m94q75xn	53	4	consist	consist	VBP
cord-018089-m94q75xn	53	5	of	of	IN
cord-018089-m94q75xn	53	6	oligosaccharides	oligosaccharide	NNS
cord-018089-m94q75xn	53	7	residing	reside	VBG
cord-018089-m94q75xn	53	8	on	on	IN
cord-018089-m94q75xn	53	9	the	the	DT
cord-018089-m94q75xn	53	10	surface	surface	NN
cord-018089-m94q75xn	53	11	of	of	IN
cord-018089-m94q75xn	53	12	respiratory	respiratory	JJ
cord-018089-m94q75xn	53	13	epithelial	epithelial	JJ
cord-018089-m94q75xn	53	14	cells	cell	NNS
cord-018089-m94q75xn	53	15	.	.	.
cord-018089-m94q75xn	54	1	Specificity	specificity	NN
cord-018089-m94q75xn	54	2	of	of	IN
cord-018089-m94q75xn	54	3	binding	binding	NN
cord-018089-m94q75xn	54	4	is	be	VBZ
cord-018089-m94q75xn	54	5	imparted	impart	VBN
cord-018089-m94q75xn	54	6	by	by	IN
cord-018089-m94q75xn	54	7	the	the	DT
cord-018089-m94q75xn	54	8	linkage	linkage	NN
cord-018089-m94q75xn	54	9	of	of	IN
cord-018089-m94q75xn	54	10	the	the	DT
cord-018089-m94q75xn	54	11	penultimate	penultimate	JJ
cord-018089-m94q75xn	54	12	galactose	galactose	NN
cord-018089-m94q75xn	54	13	(	(	-LRB-
cord-018089-m94q75xn	54	14	Gal	Gal	NNP
cord-018089-m94q75xn	54	15	)	)	-RRB-
cord-018089-m94q75xn	54	16	to	to	IN
cord-018089-m94q75xn	54	17	N	n	CD
cord-018089-m94q75xn	54	18	-	-	HYPH
cord-018089-m94q75xn	54	19	acetylsialic	acetylsialic	JJ
cord-018089-m94q75xn	54	20	acid	acid	NN
cord-018089-m94q75xn	54	21	(	(	-LRB-
cord-018089-m94q75xn	54	22	SA	SA	NNP
cord-018089-m94q75xn	54	23	)	)	-RRB-
cord-018089-m94q75xn	54	24	.	.	.
cord-018089-m94q75xn	55	1	a2,6	a2,6	NN
cord-018089-m94q75xn	55	2	linkage	linkage	NN
cord-018089-m94q75xn	55	3	(	(	-LRB-
cord-018089-m94q75xn	55	4	SAa2,6Gal	SAa2,6Gal	NNS
cord-018089-m94q75xn	55	5	)	)	-RRB-
cord-018089-m94q75xn	55	6	is	be	VBZ
cord-018089-m94q75xn	55	7	distributed	distribute	VBN
cord-018089-m94q75xn	55	8	in	in	IN
cord-018089-m94q75xn	55	9	the	the	DT
cord-018089-m94q75xn	55	10	human	human	JJ
cord-018089-m94q75xn	55	11	respiratory	respiratory	JJ
cord-018089-m94q75xn	55	12	tract	tract	NN
cord-018089-m94q75xn	55	13	and	and	CC
cord-018089-m94q75xn	55	14	is	be	VBZ
cord-018089-m94q75xn	55	15	associated	associate	VBN
cord-018089-m94q75xn	55	16	with	with	IN
cord-018089-m94q75xn	55	17	binding	bind	VBG
cord-018089-m94q75xn	55	18	to	to	IN
cord-018089-m94q75xn	55	19	human	human	JJ
cord-018089-m94q75xn	55	20	influenza	influenza	NN
cord-018089-m94q75xn	55	21	virus	virus	NN
cord-018089-m94q75xn	55	22	HA	HA	NNP
cord-018089-m94q75xn	55	23	.	.	.
cord-018089-m94q75xn	56	1	In	in	IN
cord-018089-m94q75xn	56	2	contrast	contrast	NN
cord-018089-m94q75xn	56	3	,	,	,
cord-018089-m94q75xn	56	4	avian	avian	JJ
cord-018089-m94q75xn	56	5	hosts	host	NNS
cord-018089-m94q75xn	56	6	including	include	VBG
cord-018089-m94q75xn	56	7	waterfowl	waterfowl	NNS
cord-018089-m94q75xn	56	8	and	and	CC
cord-018089-m94q75xn	56	9	domestic	domestic	JJ
cord-018089-m94q75xn	56	10	poultry	poultry	NN
cord-018089-m94q75xn	56	11	harbor	harbor	NN
cord-018089-m94q75xn	56	12	sialic	sialic	NN
cord-018089-m94q75xn	56	13	acid	acid	NN
cord-018089-m94q75xn	56	14	with	with	IN
cord-018089-m94q75xn	56	15	a2,3	a2,3	NNP
cord-018089-m94q75xn	56	16	linkage	linkage	NN
cord-018089-m94q75xn	56	17	(	(	-LRB-
cord-018089-m94q75xn	56	18	SAa2,3Gal	saa2,3gal	NN
cord-018089-m94q75xn	56	19	)	)	-RRB-
cord-018089-m94q75xn	56	20	which	which	WDT
cord-018089-m94q75xn	56	21	is	be	VBZ
cord-018089-m94q75xn	56	22	distributed	distribute	VBN
cord-018089-m94q75xn	56	23	in	in	IN
cord-018089-m94q75xn	56	24	the	the	DT
cord-018089-m94q75xn	56	25	gastrointestinal	gastrointestinal	JJ
cord-018089-m94q75xn	56	26	tract	tract	NN
cord-018089-m94q75xn	56	27	,	,	,
cord-018089-m94q75xn	56	28	reflecting	reflect	VBG
cord-018089-m94q75xn	56	29	the	the	DT
cord-018089-m94q75xn	56	30	fecal	fecal	JJ
cord-018089-m94q75xn	56	31	-	-	HYPH
cord-018089-m94q75xn	56	32	oral	oral	JJ
cord-018089-m94q75xn	56	33	mode	mode	NN
cord-018089-m94q75xn	56	34	of	of	IN
cord-018089-m94q75xn	56	35	transmission	transmission	NN
cord-018089-m94q75xn	56	36	of	of	IN
cord-018089-m94q75xn	56	37	avian	avian	JJ
cord-018089-m94q75xn	56	38	influenza	influenza	NN
cord-018089-m94q75xn	56	39	strains	strain	NNS
cord-018089-m94q75xn	56	40	in	in	IN
cord-018089-m94q75xn	56	41	these	these	DT
cord-018089-m94q75xn	56	42	species	specie	NNS
cord-018089-m94q75xn	56	43	[	[	-LRB-
cord-018089-m94q75xn	56	44	23	23	CD
cord-018089-m94q75xn	56	45	]	]	-RRB-
cord-018089-m94q75xn	56	46	.	.	.
cord-018089-m94q75xn	57	1	Specificity	specificity	NN
cord-018089-m94q75xn	57	2	of	of	IN
cord-018089-m94q75xn	57	3	viral	viral	JJ
cord-018089-m94q75xn	57	4	HA	HA	NNP
cord-018089-m94q75xn	57	5	binding	binding	NN
cord-018089-m94q75xn	57	6	is	be	VBZ
cord-018089-m94q75xn	57	7	imparted	impart	VBN
cord-018089-m94q75xn	57	8	by	by	IN
cord-018089-m94q75xn	57	9	the	the	DT
cord-018089-m94q75xn	57	10	receptor	receptor	NN
cord-018089-m94q75xn	57	11	-	-	HYPH
cord-018089-m94q75xn	57	12	binding	bind	VBG
cord-018089-m94q75xn	57	13	pocket	pocket	NN
cord-018089-m94q75xn	57	14	on	on	IN
cord-018089-m94q75xn	57	15	the	the	DT
cord-018089-m94q75xn	57	16	surface	surface	NN
cord-018089-m94q75xn	57	17	of	of	IN
cord-018089-m94q75xn	57	18	the	the	DT
cord-018089-m94q75xn	57	19	HA	HA	NNP
cord-018089-m94q75xn	57	20	molecule	molecule	NN
cord-018089-m94q75xn	57	21	(	(	-LRB-
cord-018089-m94q75xn	57	22	Fig	Fig	NNP
cord-018089-m94q75xn	57	23	.	.	NNP
cord-018089-m94q75xn	57	24	2	2	CD
cord-018089-m94q75xn	57	25	)	)	-RRB-
cord-018089-m94q75xn	57	26	.	.	.
cord-018089-m94q75xn	58	1	The	the	DT
cord-018089-m94q75xn	58	2	HA	HA	NNP
cord-018089-m94q75xn	58	3	is	be	VBZ
cord-018089-m94q75xn	58	4	a	a	DT
cord-018089-m94q75xn	58	5	rod	rod	NN
cord-018089-m94q75xn	58	6	-	-	HYPH
cord-018089-m94q75xn	58	7	shaped	shape	VBN
cord-018089-m94q75xn	58	8	trimer	trimer	NN
cord-018089-m94q75xn	58	9	anchored	anchor	VBN
cord-018089-m94q75xn	58	10	in	in	IN
cord-018089-m94q75xn	58	11	the	the	DT
cord-018089-m94q75xn	58	12	virion	virion	NN
cord-018089-m94q75xn	58	13	's	's	POS
cord-018089-m94q75xn	58	14	envelope	envelope	NN
cord-018089-m94q75xn	58	15	and	and	CC
cord-018089-m94q75xn	58	16	contains	contain	VBZ
cord-018089-m94q75xn	58	17	three	three	CD
cord-018089-m94q75xn	58	18	primary	primary	JJ
cord-018089-m94q75xn	58	19	ligand	ligand	NN
cord-018089-m94q75xn	58	20	-	-	HYPH
cord-018089-m94q75xn	58	21	binding	bind	VBG
cord-018089-m94q75xn	58	22	sites	site	NNS
cord-018089-m94q75xn	58	23	on	on	IN
cord-018089-m94q75xn	58	24	a	a	DT
cord-018089-m94q75xn	58	25	globular	globular	JJ
cord-018089-m94q75xn	58	26	head	head	NN
cord-018089-m94q75xn	58	27	[	[	-LRB-
cord-018089-m94q75xn	58	28	24	24	CD
cord-018089-m94q75xn	58	29	,	,	,
cord-018089-m94q75xn	58	30	25	25	CD
cord-018089-m94q75xn	58	31	]	]	-RRB-
cord-018089-m94q75xn	58	32	.	.	.
cord-018089-m94q75xn	59	1	Specificity	specificity	NN
cord-018089-m94q75xn	59	2	of	of	IN
cord-018089-m94q75xn	59	3	binding	binding	NN
cord-018089-m94q75xn	59	4	has	have	VBZ
cord-018089-m94q75xn	59	5	been	be	VBN
cord-018089-m94q75xn	59	6	linked	link	VBN
cord-018089-m94q75xn	59	7	to	to	IN
cord-018089-m94q75xn	59	8	certain	certain	JJ
cord-018089-m94q75xn	59	9	amino	amino	NN
cord-018089-m94q75xn	59	10	acid	acid	NN
cord-018089-m94q75xn	59	11	residues	residue	NNS
cord-018089-m94q75xn	59	12	in	in	IN
cord-018089-m94q75xn	59	13	the	the	DT
cord-018089-m94q75xn	59	14	HA	HA	NNP
cord-018089-m94q75xn	59	15	receptor	receptor	NN
cord-018089-m94q75xn	59	16	-	-	HYPH
cord-018089-m94q75xn	59	17	binding	bind	VBG
cord-018089-m94q75xn	59	18	domain	domain	NN
cord-018089-m94q75xn	59	19	.	.	.
cord-018089-m94q75xn	60	1	In	in	IN
cord-018089-m94q75xn	60	2	H3	H3	NNP
cord-018089-m94q75xn	60	3	subtypes	subtype	NNS
cord-018089-m94q75xn	60	4	,	,	,
cord-018089-m94q75xn	60	5	amino	amino	NN
cord-018089-m94q75xn	60	6	acid	acid	NN
cord-018089-m94q75xn	60	7	226	226	CD
cord-018089-m94q75xn	60	8	is	be	VBZ
cord-018089-m94q75xn	60	9	one	one	CD
cord-018089-m94q75xn	60	10	such	such	JJ
cord-018089-m94q75xn	60	11	residue	residue	NN
cord-018089-m94q75xn	60	12	,	,	,
cord-018089-m94q75xn	60	13	where	where	WRB
cord-018089-m94q75xn	60	14	the	the	DT
cord-018089-m94q75xn	60	15	presence	presence	NN
cord-018089-m94q75xn	60	16	of	of	IN
cord-018089-m94q75xn	60	17	leucine	leucine	NN
cord-018089-m94q75xn	60	18	allows	allow	VBZ
cord-018089-m94q75xn	60	19	binding	binding	NN
cord-018089-m94q75xn	60	20	of	of	IN
cord-018089-m94q75xn	60	21	SAa2,6Gal	SAa2,6Gal	NNS
cord-018089-m94q75xn	60	22	,	,	,
cord-018089-m94q75xn	60	23	whereas	whereas	IN
cord-018089-m94q75xn	60	24	the	the	DT
cord-018089-m94q75xn	60	25	presence	presence	NN
cord-018089-m94q75xn	60	26	of	of	IN
cord-018089-m94q75xn	60	27	glutamine	glutamine	NN
cord-018089-m94q75xn	60	28	at	at	IN
cord-018089-m94q75xn	60	29	this	this	DT
cord-018089-m94q75xn	60	30	position	position	NN
cord-018089-m94q75xn	60	31	permits	permit	VBZ
cord-018089-m94q75xn	60	32	binding	bind	VBG
cord-018089-m94q75xn	60	33	of	of	IN
cord-018089-m94q75xn	60	34	SAa2,3Gal	saa2,3gal	NN
cord-018089-m94q75xn	60	35	.	.	.
cord-018089-m94q75xn	61	1	Amino	amino	NN
cord-018089-m94q75xn	61	2	acid	acid	NN
cord-018089-m94q75xn	61	3	changes	change	NNS
cord-018089-m94q75xn	61	4	in	in	IN
cord-018089-m94q75xn	61	5	the	the	DT
cord-018089-m94q75xn	61	6	HA	HA	NNP
cord-018089-m94q75xn	61	7	of	of	IN
cord-018089-m94q75xn	61	8	other	other	JJ
cord-018089-m94q75xn	61	9	subtypes	subtype	NNS
cord-018089-m94q75xn	61	10	,	,	,
cord-018089-m94q75xn	61	11	such	such	JJ
cord-018089-m94q75xn	61	12	as	as	IN
cord-018089-m94q75xn	61	13	H1	h1	NN
cord-018089-m94q75xn	61	14	viruses	virus	NNS
cord-018089-m94q75xn	61	15	(	(	-LRB-
cord-018089-m94q75xn	61	16	including	include	VBG
cord-018089-m94q75xn	61	17	the	the	DT
cord-018089-m94q75xn	61	18	H1N1	H1N1	NNP
cord-018089-m94q75xn	61	19	virus	virus	NN
cord-018089-m94q75xn	61	20	responsible	responsible	JJ
cord-018089-m94q75xn	61	21	for	for	IN
cord-018089-m94q75xn	61	22	the	the	DT
cord-018089-m94q75xn	61	23	1918	1918	CD
cord-018089-m94q75xn	61	24	pandemic	pandemic	NN
cord-018089-m94q75xn	61	25	)	)	-RRB-
cord-018089-m94q75xn	61	26	,	,	,
cord-018089-m94q75xn	61	27	have	have	VBP
cord-018089-m94q75xn	61	28	been	be	VBN
cord-018089-m94q75xn	61	29	associated	associate	VBN
cord-018089-m94q75xn	61	30	with	with	IN
cord-018089-m94q75xn	61	31	adaptations	adaptation	NNS
cord-018089-m94q75xn	61	32	in	in	IN
cord-018089-m94q75xn	61	33	receptor	receptor	NN
cord-018089-m94q75xn	61	34	-	-	HYPH
cord-018089-m94q75xn	61	35	binding	bind	VBG
cord-018089-m94q75xn	61	36	specificity	specificity	NN
cord-018089-m94q75xn	61	37	,	,	,
cord-018089-m94q75xn	61	38	translating	translate	VBG
cord-018089-m94q75xn	61	39	into	into	IN
cord-018089-m94q75xn	61	40	a	a	DT
cord-018089-m94q75xn	61	41	switch	switch	NN
cord-018089-m94q75xn	61	42	in	in	IN
cord-018089-m94q75xn	61	43	host	host	NN
cord-018089-m94q75xn	61	44	specificity	specificity	NN
cord-018089-m94q75xn	61	45	with	with	IN
cord-018089-m94q75xn	61	46	disastrous	disastrous	JJ
cord-018089-m94q75xn	61	47	consequences	consequence	NNS
cord-018089-m94q75xn	61	48	[	[	-LRB-
cord-018089-m94q75xn	61	49	26	26	CD
cord-018089-m94q75xn	61	50	,	,	,
cord-018089-m94q75xn	61	51	27	27	CD
cord-018089-m94q75xn	61	52	]	]	-RRB-
cord-018089-m94q75xn	61	53	.	.	.
cord-018089-m94q75xn	62	1	Specifically	specifically	RB
cord-018089-m94q75xn	62	2	,	,	,
cord-018089-m94q75xn	62	3	changes	change	NNS
cord-018089-m94q75xn	62	4	at	at	IN
cord-018089-m94q75xn	62	5	amino	amino	NN
cord-018089-m94q75xn	62	6	acid	acid	NN
cord-018089-m94q75xn	62	7	position	position	NN
cord-018089-m94q75xn	62	8	225	225	CD
cord-018089-m94q75xn	62	9	impart	impart	VB
cord-018089-m94q75xn	62	10	the	the	DT
cord-018089-m94q75xn	62	11	ability	ability	NN
cord-018089-m94q75xn	62	12	of	of	IN
cord-018089-m94q75xn	62	13	A	a	DT
cord-018089-m94q75xn	62	14	/	/	SYM
cord-018089-m94q75xn	62	15	New	New	NNP
cord-018089-m94q75xn	62	16	York/1/18	York/1/18	NNP
cord-018089-m94q75xn	62	17	to	to	TO
cord-018089-m94q75xn	62	18	bind	bind	VB
cord-018089-m94q75xn	62	19	both	both	DT
cord-018089-m94q75xn	62	20	avian	avian	JJ
cord-018089-m94q75xn	62	21	and	and	CC
cord-018089-m94q75xn	62	22	human	human	JJ
cord-018089-m94q75xn	62	23	host	host	NN
cord-018089-m94q75xn	62	24	influenza	influenza	NN
cord-018089-m94q75xn	62	25	virus	virus	NN
cord-018089-m94q75xn	62	26	receptors	receptor	NNS
cord-018089-m94q75xn	62	27	[	[	-LRB-
cord-018089-m94q75xn	62	28	26	26	CD
cord-018089-m94q75xn	62	29	]	]	-RRB-
cord-018089-m94q75xn	62	30	.	.	.
cord-018089-m94q75xn	63	1	Strains	strain	NNS
cord-018089-m94q75xn	63	2	of	of	IN
cord-018089-m94q75xn	63	3	the	the	DT
cord-018089-m94q75xn	63	4	2009	2009	CD
cord-018089-m94q75xn	63	5	pandemic	pandemic	NN
cord-018089-m94q75xn	63	6	H1N1	H1N1	NNP
cord-018089-m94q75xn	63	7	influenza	influenza	NN
cord-018089-m94q75xn	63	8	viruses	virus	NNS
cord-018089-m94q75xn	63	9	retain	retain	VBP
cord-018089-m94q75xn	63	10	amino	amino	JJ
cord-018089-m94q75xn	63	11	acids	acid	NNS
cord-018089-m94q75xn	63	12	(	(	-LRB-
cord-018089-m94q75xn	63	13	aspartic	aspartic	JJ
cord-018089-m94q75xn	63	14	acids	acid	NNS
cord-018089-m94q75xn	63	15	)	)	-RRB-
cord-018089-m94q75xn	63	16	at	at	IN
cord-018089-m94q75xn	63	17	positions	position	NNS
cord-018089-m94q75xn	63	18	190	190	CD
cord-018089-m94q75xn	63	19	and	and	CC
cord-018089-m94q75xn	63	20	225	225	CD
cord-018089-m94q75xn	63	21	of	of	IN
cord-018089-m94q75xn	63	22	the	the	DT
cord-018089-m94q75xn	63	23	HA	HA	NNP
cord-018089-m94q75xn	63	24	consistent	consistent	JJ
cord-018089-m94q75xn	63	25	with	with	IN
cord-018089-m94q75xn	63	26	human	human	JJ
cord-018089-m94q75xn	63	27	sialic	sialic	NN
cord-018089-m94q75xn	63	28	acid	acid	NN
cord-018089-m94q75xn	63	29	receptorbinding	receptorbinding	NN
cord-018089-m94q75xn	63	30	specificity	specificity	NN
cord-018089-m94q75xn	63	31	,	,	,
cord-018089-m94q75xn	63	32	although	although	IN
cord-018089-m94q75xn	63	33	conflicting	conflicting	JJ
cord-018089-m94q75xn	63	34	data	datum	NNS
cord-018089-m94q75xn	63	35	exist	exist	VBP
cord-018089-m94q75xn	63	36	regarding	regard	VBG
cord-018089-m94q75xn	63	37	binding	bind	VBG
cord-018089-m94q75xn	63	38	specificity	specificity	NN
cord-018089-m94q75xn	63	39	for	for	IN
cord-018089-m94q75xn	63	40	these	these	DT
cord-018089-m94q75xn	63	41	viruses	virus	NNS
cord-018089-m94q75xn	63	42	.	.	.
cord-018089-m94q75xn	64	1	One	one	CD
cord-018089-m94q75xn	64	2	approach	approach	NN
cord-018089-m94q75xn	64	3	utilizing	utilize	VBG
cord-018089-m94q75xn	64	4	carbohydrate	carbohydrate	NN
cord-018089-m94q75xn	64	5	microarrays	microarray	NNS
cord-018089-m94q75xn	64	6	suggests	suggest	VBZ
cord-018089-m94q75xn	64	7	that	that	IN
cord-018089-m94q75xn	64	8	dual	dual	JJ
cord-018089-m94q75xn	64	9	(	(	-LRB-
cord-018089-m94q75xn	64	10	human	human	JJ
cord-018089-m94q75xn	64	11	and	and	CC
cord-018089-m94q75xn	64	12	avian	avian	JJ
cord-018089-m94q75xn	64	13	)	)	-RRB-
cord-018089-m94q75xn	64	14	sialic	sialic	JJ
cord-018089-m94q75xn	64	15	acid	acid	NN
cord-018089-m94q75xn	64	16	receptor	receptor	NN
cord-018089-m94q75xn	64	17	binding	binding	NN
cord-018089-m94q75xn	64	18	occurs	occur	VBZ
cord-018089-m94q75xn	64	19	[	[	-LRB-
cord-018089-m94q75xn	64	20	28	28	CD
cord-018089-m94q75xn	64	21	]	]	-RRB-
cord-018089-m94q75xn	64	22	;	;	:
cord-018089-m94q75xn	64	23	data	datum	NNS
cord-018089-m94q75xn	64	24	obtained	obtain	VBD
cord-018089-m94q75xn	64	25	using	use	VBG
cord-018089-m94q75xn	64	26	a	a	DT
cord-018089-m94q75xn	64	27	different	different	JJ
cord-018089-m94q75xn	64	28	approach	approach	NN
cord-018089-m94q75xn	64	29	,	,	,
cord-018089-m94q75xn	64	30	namely	namely	RB
cord-018089-m94q75xn	64	31	biotinylated	biotinylate	VBN
cord-018089-m94q75xn	64	32	a2,3and	a2,3and	NNP
cord-018089-m94q75xn	64	33	a2,6-sialylated	a2,6-sialylated	NNP
cord-018089-m94q75xn	64	34	glycans	glycan	NNS
cord-018089-m94q75xn	64	35	,	,	,
cord-018089-m94q75xn	64	36	suggest	suggest	VBP
cord-018089-m94q75xn	64	37	currently	currently	RB
cord-018089-m94q75xn	64	38	circulating	circulate	VBG
cord-018089-m94q75xn	64	39	pandemic	pandemic	NN
cord-018089-m94q75xn	64	40	viruses	virus	NNS
cord-018089-m94q75xn	64	41	preferentially	preferentially	RB
cord-018089-m94q75xn	64	42	bind	bind	VBP
cord-018089-m94q75xn	64	43	human	human	JJ
cord-018089-m94q75xn	64	44	sialic	sialic	NN
cord-018089-m94q75xn	64	45	acid	acid	NN
cord-018089-m94q75xn	64	46	receptors	receptor	NNS
cord-018089-m94q75xn	64	47	with	with	IN
cord-018089-m94q75xn	64	48	a2	a2	NNP
cord-018089-m94q75xn	64	49	-	-	HYPH
cord-018089-m94q75xn	64	50	6	6	CD
cord-018089-m94q75xn	64	51	linkage	linkage	NN
cord-018089-m94q75xn	64	52	[	[	-LRB-
cord-018089-m94q75xn	64	53	29	29	CD
cord-018089-m94q75xn	64	54	]	]	-RRB-
cord-018089-m94q75xn	64	55	.	.	.
cord-018089-m94q75xn	65	1	The	the	DT
cord-018089-m94q75xn	65	2	importance	importance	NN
cord-018089-m94q75xn	65	3	of	of	IN
cord-018089-m94q75xn	65	4	these	these	DT
cord-018089-m94q75xn	65	5	amino	amino	NN
cord-018089-m94q75xn	65	6	acid	acid	NN
cord-018089-m94q75xn	65	7	residues	residue	NNS
cord-018089-m94q75xn	65	8	to	to	IN
cord-018089-m94q75xn	65	9	respiratory	respiratory	JJ
cord-018089-m94q75xn	65	10	droplet	droplet	NN
cord-018089-m94q75xn	65	11	transmission	transmission	NN
cord-018089-m94q75xn	65	12	has	have	VBZ
cord-018089-m94q75xn	65	13	recently	recently	RB
cord-018089-m94q75xn	65	14	been	be	VBN
cord-018089-m94q75xn	65	15	described	describe	VBN
cord-018089-m94q75xn	65	16	using	use	VBG
cord-018089-m94q75xn	65	17	the	the	DT
cord-018089-m94q75xn	65	18	ferret	ferret	JJ
cord-018089-m94q75xn	65	19	transmission	transmission	NN
cord-018089-m94q75xn	65	20	model	model	NN
cord-018089-m94q75xn	65	21	.	.	.
cord-018089-m94q75xn	66	1	H1N1	H1N1	NNP
cord-018089-m94q75xn	66	2	viruses	virus	NNS
cord-018089-m94q75xn	66	3	containing	contain	VBG
cord-018089-m94q75xn	66	4	aspartic	aspartic	JJ
cord-018089-m94q75xn	66	5	acids	acid	NNS
cord-018089-m94q75xn	66	6	at	at	IN
cord-018089-m94q75xn	66	7	residues	residue	NNS
cord-018089-m94q75xn	66	8	190	190	CD
cord-018089-m94q75xn	66	9	and	and	CC
cord-018089-m94q75xn	66	10	225	225	CD
cord-018089-m94q75xn	66	11	were	be	VBD
cord-018089-m94q75xn	66	12	capable	capable	JJ
cord-018089-m94q75xn	66	13	of	of	IN
cord-018089-m94q75xn	66	14	aerosol	aerosol	NN
cord-018089-m94q75xn	66	15	transmission	transmission	NN
cord-018089-m94q75xn	66	16	.	.	.
cord-018089-m94q75xn	67	1	This	this	DT
cord-018089-m94q75xn	67	2	contrasted	contrast	VBD
cord-018089-m94q75xn	67	3	with	with	IN
cord-018089-m94q75xn	67	4	H1N1	H1N1	NNP
cord-018089-m94q75xn	67	5	viruses	virus	NNS
cord-018089-m94q75xn	67	6	with	with	IN
cord-018089-m94q75xn	67	7	glutamic	glutamic	NN
cord-018089-m94q75xn	67	8	acid	acid	NN
cord-018089-m94q75xn	67	9	and	and	CC
cord-018089-m94q75xn	67	10	glycine	glycine	NN
cord-018089-m94q75xn	67	11	at	at	IN
cord-018089-m94q75xn	67	12	residues	residue	NNS
cord-018089-m94q75xn	67	13	190	190	CD
cord-018089-m94q75xn	67	14	and	and	CC
cord-018089-m94q75xn	67	15	225	225	CD
cord-018089-m94q75xn	67	16	,	,	,
cord-018089-m94q75xn	67	17	respectively	respectively	RB
cord-018089-m94q75xn	67	18	(	(	-LRB-
cord-018089-m94q75xn	67	19	consistent	consistent	JJ
cord-018089-m94q75xn	67	20	with	with	IN
cord-018089-m94q75xn	67	21	avian	avian	JJ
cord-018089-m94q75xn	67	22	sialic	sialic	NN
cord-018089-m94q75xn	67	23	acid	acid	NN
cord-018089-m94q75xn	67	24	receptor	receptor	NN
cord-018089-m94q75xn	67	25	-	-	HYPH
cord-018089-m94q75xn	67	26	binding	bind	VBG
cord-018089-m94q75xn	67	27	specificity	specificity	NN
cord-018089-m94q75xn	67	28	)	)	-RRB-
cord-018089-m94q75xn	67	29	,	,	,
cord-018089-m94q75xn	67	30	which	which	WDT
cord-018089-m94q75xn	67	31	did	do	VBD
cord-018089-m94q75xn	67	32	not	not	RB
cord-018089-m94q75xn	67	33	transmit	transmit	VB
cord-018089-m94q75xn	67	34	through	through	IN
cord-018089-m94q75xn	67	35	the	the	DT
cord-018089-m94q75xn	67	36	air	air	NN
cord-018089-m94q75xn	67	37	[	[	-LRB-
cord-018089-m94q75xn	67	38	30	30	CD
cord-018089-m94q75xn	67	39	]	]	-RRB-
cord-018089-m94q75xn	67	40	.	.	.
cord-018089-m94q75xn	68	1	Furthermore	furthermore	RB
cord-018089-m94q75xn	68	2	,	,	,
cord-018089-m94q75xn	68	3	other	other	JJ
cord-018089-m94q75xn	68	4	changes	change	NNS
cord-018089-m94q75xn	68	5	in	in	IN
cord-018089-m94q75xn	68	6	the	the	DT
cord-018089-m94q75xn	68	7	HA	HA	NNP
cord-018089-m94q75xn	68	8	(	(	-LRB-
cord-018089-m94q75xn	68	9	and	and	CC
cord-018089-m94q75xn	68	10	NA	NA	NNP
cord-018089-m94q75xn	68	11	)	)	-RRB-
cord-018089-m94q75xn	68	12	of	of	IN
cord-018089-m94q75xn	68	13	an	an	DT
cord-018089-m94q75xn	68	14	avian	avian	JJ
cord-018089-m94q75xn	68	15	H9N2	H9N2	NNP
cord-018089-m94q75xn	68	16	after	after	IN
cord-018089-m94q75xn	68	17	adaptation	adaptation	NN
cord-018089-m94q75xn	68	18	in	in	IN
cord-018089-m94q75xn	68	19	the	the	DT
cord-018089-m94q75xn	68	20	ferret	ferret	NN
cord-018089-m94q75xn	68	21	conferred	confer	VBD
cord-018089-m94q75xn	68	22	a	a	DT
cord-018089-m94q75xn	68	23	more	more	RBR
cord-018089-m94q75xn	68	24	efficient	efficient	JJ
cord-018089-m94q75xn	68	25	respiratory	respiratory	JJ
cord-018089-m94q75xn	68	26	transmission	transmission	NN
cord-018089-m94q75xn	68	27	phenotype	phenotype	NN
cord-018089-m94q75xn	68	28	[	[	-LRB-
cord-018089-m94q75xn	68	29	31	31	CD
cord-018089-m94q75xn	68	30	]	]	-RRB-
cord-018089-m94q75xn	68	31	.	.	.
cord-018089-m94q75xn	69	1	Several	several	JJ
cord-018089-m94q75xn	69	2	possible	possible	JJ
cord-018089-m94q75xn	69	3	pathways	pathway	NNS
cord-018089-m94q75xn	69	4	for	for	IN
cord-018089-m94q75xn	69	5	the	the	DT
cord-018089-m94q75xn	69	6	entry	entry	NN
cord-018089-m94q75xn	69	7	of	of	IN
cord-018089-m94q75xn	69	8	influenza	influenza	NN
cord-018089-m94q75xn	69	9	viruses	virus	NNS
cord-018089-m94q75xn	69	10	into	into	IN
cord-018089-m94q75xn	69	11	host	host	NN
cord-018089-m94q75xn	69	12	cells	cell	NNS
cord-018089-m94q75xn	69	13	have	have	VBP
cord-018089-m94q75xn	69	14	been	be	VBN
cord-018089-m94q75xn	69	15	postulated	postulate	VBN
cord-018089-m94q75xn	69	16	and	and	CC
cord-018089-m94q75xn	69	17	recently	recently	RB
cord-018089-m94q75xn	69	18	reviewed	review	VBD
cord-018089-m94q75xn	69	19	[	[	-LRB-
cord-018089-m94q75xn	69	20	32	32	CD
cord-018089-m94q75xn	69	21	]	]	-RRB-
cord-018089-m94q75xn	69	22	.	.	.
cord-018089-m94q75xn	70	1	Endocytosis	endocytosis	NN
cord-018089-m94q75xn	70	2	is	be	VBZ
cord-018089-m94q75xn	70	3	a	a	DT
cord-018089-m94q75xn	70	4	multistep	multistep	JJ
cord-018089-m94q75xn	70	5	process	process	NN
cord-018089-m94q75xn	70	6	consisting	consist	VBG
cord-018089-m94q75xn	70	7	of	of	IN
cord-018089-m94q75xn	70	8	surface	surface	NN
cord-018089-m94q75xn	70	9	receptor	receptor	NN
cord-018089-m94q75xn	70	10	-	-	HYPH
cord-018089-m94q75xn	70	11	mediated	mediate	VBN
cord-018089-m94q75xn	70	12	binding	binding	NN
cord-018089-m94q75xn	70	13	,	,	,
cord-018089-m94q75xn	70	14	internalization	internalization	NN
cord-018089-m94q75xn	70	15	,	,	,
cord-018089-m94q75xn	70	16	and	and	CC
cord-018089-m94q75xn	70	17	intracellular	intracellular	JJ
cord-018089-m94q75xn	70	18	trafficking	trafficking	NN
cord-018089-m94q75xn	70	19	.	.	.
cord-018089-m94q75xn	71	1	Clathrin	Clathrin	NNP
cord-018089-m94q75xn	71	2	-	-	HYPH
cord-018089-m94q75xn	71	3	mediated	mediate	VBN
cord-018089-m94q75xn	71	4	and	and	CC
cord-018089-m94q75xn	71	5	clathrin	clathrin	NN
cord-018089-m94q75xn	71	6	-	-	HYPH
cord-018089-m94q75xn	71	7	independent	independent	JJ
cord-018089-m94q75xn	71	8	internalization	internalization	NN
cord-018089-m94q75xn	71	9	via	via	IN
cord-018089-m94q75xn	71	10	caveolae	caveolae	NNP
cord-018089-m94q75xn	71	11	and	and	CC
cord-018089-m94q75xn	71	12	caveolae	caveolae	NNP
cord-018089-m94q75xn	71	13	-	-	HYPH
cord-018089-m94q75xn	71	14	independent	independent	JJ
cord-018089-m94q75xn	71	15	endocytosis	endocytosis	NN
cord-018089-m94q75xn	71	16	have	have	VBP
cord-018089-m94q75xn	71	17	been	be	VBN
cord-018089-m94q75xn	71	18	demonstrated	demonstrate	VBN
cord-018089-m94q75xn	71	19	[	[	-LRB-
cord-018089-m94q75xn	71	20	33	33	CD
cord-018089-m94q75xn	71	21	,	,	,
cord-018089-m94q75xn	71	22	34	34	CD
cord-018089-m94q75xn	71	23	]	]	-RRB-
cord-018089-m94q75xn	71	24	.	.	.
cord-018089-m94q75xn	72	1	An	an	DT
cord-018089-m94q75xn	72	2	initial	initial	JJ
cord-018089-m94q75xn	72	3	acidification	acidification	NN
cord-018089-m94q75xn	72	4	step	step	NN
cord-018089-m94q75xn	72	5	in	in	IN
cord-018089-m94q75xn	72	6	early	early	JJ
cord-018089-m94q75xn	72	7	endosomes	endosome	NNS
cord-018089-m94q75xn	72	8	is	be	VBZ
cord-018089-m94q75xn	72	9	followed	follow	VBN
cord-018089-m94q75xn	72	10	by	by	IN
cord-018089-m94q75xn	72	11	trafficking	traffic	VBG
cord-018089-m94q75xn	72	12	to	to	IN
cord-018089-m94q75xn	72	13	low	low	JJ
cord-018089-m94q75xn	72	14	-	-	HYPH
cord-018089-m94q75xn	72	15	pH	ph	NN
cord-018089-m94q75xn	72	16	late	late	JJ
cord-018089-m94q75xn	72	17	endosomes	endosome	NNS
cord-018089-m94q75xn	72	18	,	,	,
cord-018089-m94q75xn	72	19	a	a	DT
cord-018089-m94q75xn	72	20	process	process	NN
cord-018089-m94q75xn	72	21	mediated	mediate	VBN
cord-018089-m94q75xn	72	22	by	by	IN
cord-018089-m94q75xn	72	23	members	member	NNS
cord-018089-m94q75xn	72	24	of	of	IN
cord-018089-m94q75xn	72	25	the	the	DT
cord-018089-m94q75xn	72	26	Rab	Rab	NNP
cord-018089-m94q75xn	72	27	host	host	NN
cord-018089-m94q75xn	72	28	protein	protein	NN
cord-018089-m94q75xn	72	29	family	family	NN
cord-018089-m94q75xn	72	30	.	.	.
cord-018089-m94q75xn	73	1	Fusion	fusion	NN
cord-018089-m94q75xn	73	2	of	of	IN
cord-018089-m94q75xn	73	3	influenza	influenza	NN
cord-018089-m94q75xn	73	4	virus	virus	NN
cord-018089-m94q75xn	73	5	to	to	IN
cord-018089-m94q75xn	73	6	the	the	DT
cord-018089-m94q75xn	73	7	endosome	endosome	NN
cord-018089-m94q75xn	73	8	is	be	VBZ
cord-018089-m94q75xn	73	9	triggered	trigger	VBN
cord-018089-m94q75xn	73	10	by	by	IN
cord-018089-m94q75xn	73	11	low	low	JJ
cord-018089-m94q75xn	73	12	pH	ph	NN
cord-018089-m94q75xn	73	13	conditions	condition	NNS
cord-018089-m94q75xn	73	14	and	and	CC
cord-018089-m94q75xn	73	15	mediated	mediate	VBN
cord-018089-m94q75xn	73	16	by	by	IN
cord-018089-m94q75xn	73	17	the	the	DT
cord-018089-m94q75xn	73	18	fusion	fusion	NN
cord-018089-m94q75xn	73	19	peptide	peptide	NN
cord-018089-m94q75xn	73	20	of	of	IN
cord-018089-m94q75xn	73	21	HA2	HA2	NNP
cord-018089-m94q75xn	73	22	after	after	IN
cord-018089-m94q75xn	73	23	cleavage	cleavage	NN
cord-018089-m94q75xn	73	24	of	of	IN
cord-018089-m94q75xn	73	25	HA	HA	NNP
cord-018089-m94q75xn	73	26	,	,	,
cord-018089-m94q75xn	73	27	creating	create	VBG
cord-018089-m94q75xn	73	28	a	a	DT
cord-018089-m94q75xn	73	29	pore	pore	NN
cord-018089-m94q75xn	73	30	in	in	IN
cord-018089-m94q75xn	73	31	the	the	DT
cord-018089-m94q75xn	73	32	endosome	endosome	NN
cord-018089-m94q75xn	73	33	through	through	IN
cord-018089-m94q75xn	73	34	fusion	fusion	NN
cord-018089-m94q75xn	73	35	of	of	IN
cord-018089-m94q75xn	73	36	viral	viral	JJ
cord-018089-m94q75xn	73	37	and	and	CC
cord-018089-m94q75xn	73	38	endosomal	endosomal	JJ
cord-018089-m94q75xn	73	39	membranes	membrane	NNS
cord-018089-m94q75xn	73	40	(	(	-LRB-
cord-018089-m94q75xn	73	41	Fig	Fig	NNP
cord-018089-m94q75xn	73	42	.	.	.
cord-018089-m94q75xn	73	43	3	3	LS
cord-018089-m94q75xn	73	44	)	)	-RRB-
cord-018089-m94q75xn	73	45	[	[	-LRB-
cord-018089-m94q75xn	73	46	3	3	CD
cord-018089-m94q75xn	73	47	]	]	-RRB-
cord-018089-m94q75xn	73	48	.	.	.
cord-018089-m94q75xn	74	1	Subsequent	subsequent	JJ
cord-018089-m94q75xn	74	2	steps	step	NNS
cord-018089-m94q75xn	74	3	in	in	IN
cord-018089-m94q75xn	74	4	the	the	DT
cord-018089-m94q75xn	74	5	uncoating	uncoating	NN
cord-018089-m94q75xn	74	6	process	process	NN
cord-018089-m94q75xn	74	7	involve	involve	VBP
cord-018089-m94q75xn	74	8	the	the	DT
cord-018089-m94q75xn	74	9	influenza	influenza	NN
cord-018089-m94q75xn	74	10	virus	virus	NN
cord-018089-m94q75xn	74	11	tetrameric	tetrameric	JJ
cord-018089-m94q75xn	74	12	M2	M2	NNP
cord-018089-m94q75xn	74	13	protein	protein	NN
cord-018089-m94q75xn	74	14	,	,	,
cord-018089-m94q75xn	74	15	which	which	WDT
cord-018089-m94q75xn	74	16	is	be	VBZ
cord-018089-m94q75xn	74	17	involved	involve	VBN
cord-018089-m94q75xn	74	18	in	in	IN
cord-018089-m94q75xn	74	19	the	the	DT
cord-018089-m94q75xn	74	20	release	release	NN
cord-018089-m94q75xn	74	21	of	of	IN
cord-018089-m94q75xn	74	22	RNP	RNP	NNP
cord-018089-m94q75xn	74	23	into	into	IN
cord-018089-m94q75xn	74	24	the	the	DT
cord-018089-m94q75xn	74	25	host	host	NN
cord-018089-m94q75xn	74	26	cell	cell	NN
cord-018089-m94q75xn	74	27	cytoplasm	cytoplasm	NN
cord-018089-m94q75xn	74	28	through	through	IN
cord-018089-m94q75xn	74	29	ion	ion	NN
cord-018089-m94q75xn	74	30	channel	channel	NN
cord-018089-m94q75xn	74	31	activity	activity	NN
cord-018089-m94q75xn	74	32	[	[	-LRB-
cord-018089-m94q75xn	74	33	35	35	CD
cord-018089-m94q75xn	74	34	,	,	,
cord-018089-m94q75xn	74	35	36	36	CD
cord-018089-m94q75xn	74	36	]	]	-RRB-
cord-018089-m94q75xn	74	37	.	.	.
cord-018089-m94q75xn	75	1	Viral	Viral	NNP
cord-018089-m94q75xn	75	2	RNA	RNA	NNP
cord-018089-m94q75xn	75	3	(	(	-LRB-
cord-018089-m94q75xn	75	4	vRNA	vrna	JJ
cord-018089-m94q75xn	75	5	)	)	-RRB-
cord-018089-m94q75xn	75	6	synthesis	synthesis	NN
cord-018089-m94q75xn	75	7	occurs	occur	VBZ
cord-018089-m94q75xn	75	8	in	in	IN
cord-018089-m94q75xn	75	9	the	the	DT
cord-018089-m94q75xn	75	10	nucleus	nucleus	NN
cord-018089-m94q75xn	75	11	,	,	,
cord-018089-m94q75xn	75	12	and	and	CC
cord-018089-m94q75xn	75	13	viral	viral	JJ
cord-018089-m94q75xn	75	14	RNPs	rnp	NNS
cord-018089-m94q75xn	75	15	must	must	MD
cord-018089-m94q75xn	75	16	therefore	therefore	RB
cord-018089-m94q75xn	75	17	be	be	VB
cord-018089-m94q75xn	75	18	imported	import	VBN
cord-018089-m94q75xn	75	19	.	.	.
cord-018089-m94q75xn	76	1	This	this	DT
cord-018089-m94q75xn	76	2	process	process	NN
cord-018089-m94q75xn	76	3	is	be	VBZ
cord-018089-m94q75xn	76	4	primarily	primarily	RB
cord-018089-m94q75xn	76	5	mediated	mediate	VBN
cord-018089-m94q75xn	76	6	by	by	IN
cord-018089-m94q75xn	76	7	viral	viral	JJ
cord-018089-m94q75xn	76	8	NP	NP	NNP
cord-018089-m94q75xn	76	9	,	,	,
cord-018089-m94q75xn	76	10	which	which	WDT
cord-018089-m94q75xn	76	11	coats	coat	VBZ
cord-018089-m94q75xn	76	12	viral	viral	JJ
cord-018089-m94q75xn	76	13	RNA	RNA	NNP
cord-018089-m94q75xn	76	14	and	and	CC
cord-018089-m94q75xn	76	15	possesses	possess	VBZ
cord-018089-m94q75xn	76	16	nuclear	nuclear	JJ
cord-018089-m94q75xn	76	17	localization	localization	NN
cord-018089-m94q75xn	76	18	signals	signal	NNS
cord-018089-m94q75xn	76	19	(	(	-LRB-
cord-018089-m94q75xn	76	20	NLSs	NLSs	NNPS
cord-018089-m94q75xn	76	21	)	)	-RRB-
cord-018089-m94q75xn	76	22	,	,	,
cord-018089-m94q75xn	76	23	including	include	VBG
cord-018089-m94q75xn	76	24	an	an	DT
cord-018089-m94q75xn	76	25	unconventional	unconventional	JJ
cord-018089-m94q75xn	76	26	NLS	nls	NN
cord-018089-m94q75xn	76	27	which	which	WDT
cord-018089-m94q75xn	76	28	binds	bind	VBZ
cord-018089-m94q75xn	76	29	host	host	NN
cord-018089-m94q75xn	76	30	karyopherin	karyopherin	NNP
cord-018089-m94q75xn	76	31	-	-	:
cord-018089-m94q75xn	76	32	a	a	NN
cord-018089-m94q75xn	76	33	and	and	CC
cord-018089-m94q75xn	76	34	is	be	VBZ
cord-018089-m94q75xn	76	35	essential	essential	JJ
cord-018089-m94q75xn	76	36	for	for	IN
cord-018089-m94q75xn	76	37	energy	energy	NN
cord-018089-m94q75xn	76	38	-	-	HYPH
cord-018089-m94q75xn	76	39	dependent	dependent	JJ
cord-018089-m94q75xn	76	40	RNP	RNP	NNP
cord-018089-m94q75xn	76	41	nuclear	nuclear	JJ
cord-018089-m94q75xn	76	42	import	import	NN
cord-018089-m94q75xn	76	43	[	[	-LRB-
cord-018089-m94q75xn	76	44	37	37	CD
cord-018089-m94q75xn	76	45	,	,	,
cord-018089-m94q75xn	76	46	38	38	CD
cord-018089-m94q75xn	76	47	]	]	-RRB-
cord-018089-m94q75xn	76	48	.	.	.
cord-018089-m94q75xn	77	1	Viral	Viral	NNP
cord-018089-m94q75xn	77	2	RNA	RNA	NNP
cord-018089-m94q75xn	77	3	serves	serve	VBZ
cord-018089-m94q75xn	77	4	as	as	IN
cord-018089-m94q75xn	77	5	a	a	DT
cord-018089-m94q75xn	77	6	template	template	NN
cord-018089-m94q75xn	77	7	for	for	IN
cord-018089-m94q75xn	77	8	the	the	DT
cord-018089-m94q75xn	77	9	production	production	NN
cord-018089-m94q75xn	77	10	of	of	IN
cord-018089-m94q75xn	77	11	messenger	messenger	NNP
cord-018089-m94q75xn	77	12	RNA	RNA	NNP
cord-018089-m94q75xn	77	13	(	(	-LRB-
cord-018089-m94q75xn	77	14	mRNA	mRNA	NNP
cord-018089-m94q75xn	77	15	)	)	-RRB-
cord-018089-m94q75xn	77	16	and	and	CC
cord-018089-m94q75xn	77	17	subsequent	subsequent	JJ
cord-018089-m94q75xn	77	18	transcription	transcription	NN
cord-018089-m94q75xn	77	19	,	,	,
cord-018089-m94q75xn	77	20	as	as	RB
cord-018089-m94q75xn	77	21	well	well	RB
cord-018089-m94q75xn	77	22	as	as	IN
cord-018089-m94q75xn	77	23	for	for	IN
cord-018089-m94q75xn	77	24	the	the	DT
cord-018089-m94q75xn	77	25	generation	generation	NN
cord-018089-m94q75xn	77	26	of	of	IN
cord-018089-m94q75xn	77	27	complementary	complementary	JJ
cord-018089-m94q75xn	77	28	RNA	RNA	NNP
cord-018089-m94q75xn	77	29	(	(	-LRB-
cord-018089-m94q75xn	77	30	cRNA	cRNA	NNS
cord-018089-m94q75xn	77	31	)	)	-RRB-
cord-018089-m94q75xn	77	32	,	,	,
cord-018089-m94q75xn	77	33	which	which	WDT
cord-018089-m94q75xn	77	34	is	be	VBZ
cord-018089-m94q75xn	77	35	positive	positive	JJ
cord-018089-m94q75xn	77	36	sense	sense	NN
cord-018089-m94q75xn	77	37	and	and	CC
cord-018089-m94q75xn	77	38	functions	function	NNS
cord-018089-m94q75xn	77	39	as	as	IN
cord-018089-m94q75xn	77	40	a	a	DT
cord-018089-m94q75xn	77	41	template	template	NN
cord-018089-m94q75xn	77	42	for	for	IN
cord-018089-m94q75xn	77	43	the	the	DT
cord-018089-m94q75xn	77	44	generation	generation	NN
cord-018089-m94q75xn	77	45	of	of	IN
cord-018089-m94q75xn	77	46	more	more	JJR
cord-018089-m94q75xn	77	47	vRNA	vrna	JJ
cord-018089-m94q75xn	77	48	(	(	-LRB-
cord-018089-m94q75xn	77	49	viral	viral	JJ
cord-018089-m94q75xn	77	50	replication	replication	NN
cord-018089-m94q75xn	77	51	)	)	-RRB-
cord-018089-m94q75xn	77	52	.	.	.
cord-018089-m94q75xn	78	1	RNA	RNA	NNP
cord-018089-m94q75xn	78	2	segments	segment	NNS
cord-018089-m94q75xn	78	3	are	be	VBP
cord-018089-m94q75xn	78	4	coated	coat	VBN
cord-018089-m94q75xn	78	5	by	by	IN
cord-018089-m94q75xn	78	6	NP	NP	NNP
cord-018089-m94q75xn	78	7	through	through	IN
cord-018089-m94q75xn	78	8	nonspecific	nonspecific	JJ
cord-018089-m94q75xn	78	9	interactions	interaction	NNS
cord-018089-m94q75xn	78	10	between	between	IN
cord-018089-m94q75xn	78	11	the	the	DT
cord-018089-m94q75xn	78	12	arginine	arginine	NN
cord-018089-m94q75xn	78	13	-	-	HYPH
cord-018089-m94q75xn	78	14	rich	rich	JJ
cord-018089-m94q75xn	78	15	positively	positively	RB
cord-018089-m94q75xn	78	16	charged	charge	VBD
cord-018089-m94q75xn	78	17	NP	NP	NNP
cord-018089-m94q75xn	78	18	and	and	CC
cord-018089-m94q75xn	78	19	the	the	DT
cord-018089-m94q75xn	78	20	negatively	negatively	RB
cord-018089-m94q75xn	78	21	charged	charge	VBN
cord-018089-m94q75xn	78	22	RNA	rna	NN
cord-018089-m94q75xn	78	23	phosphate	phosphate	NN
cord-018089-m94q75xn	78	24	backbone	backbone	NN
cord-018089-m94q75xn	78	25	[	[	-LRB-
cord-018089-m94q75xn	78	26	3	3	CD
cord-018089-m94q75xn	78	27	]	]	-RRB-
cord-018089-m94q75xn	78	28	.	.	.
cord-018089-m94q75xn	79	1	The	the	DT
cord-018089-m94q75xn	79	2	viral	viral	JJ
cord-018089-m94q75xn	79	3	polymerase	polymerase	NN
cord-018089-m94q75xn	79	4	complex	complex	NN
cord-018089-m94q75xn	79	5	consists	consist	VBZ
cord-018089-m94q75xn	79	6	of	of	IN
cord-018089-m94q75xn	79	7	tightly	tightly	RB
cord-018089-m94q75xn	79	8	associated	associate	VBN
cord-018089-m94q75xn	79	9	PB1	PB1	NNP
cord-018089-m94q75xn	79	10	,	,	,
cord-018089-m94q75xn	79	11	PB2	PB2	NNP
cord-018089-m94q75xn	79	12	,	,	,
cord-018089-m94q75xn	79	13	and	and	CC
cord-018089-m94q75xn	79	14	PA	PA	NNP
cord-018089-m94q75xn	79	15	and	and	CC
cord-018089-m94q75xn	79	16	associates	associate	NNS
cord-018089-m94q75xn	79	17	with	with	IN
cord-018089-m94q75xn	79	18	NP	NP	NNP
cord-018089-m94q75xn	79	19	-	-	HYPH
cord-018089-m94q75xn	79	20	coated	coat	VBN
cord-018089-m94q75xn	79	21	RNA	RNA	NNP
cord-018089-m94q75xn	79	22	without	without	IN
cord-018089-m94q75xn	79	23	disrupting	disrupt	VBG
cord-018089-m94q75xn	79	24	this	this	DT
cord-018089-m94q75xn	79	25	interaction	interaction	NN
cord-018089-m94q75xn	79	26	[	[	-LRB-
cord-018089-m94q75xn	79	27	39	39	CD
cord-018089-m94q75xn	79	28	]	]	-RRB-
cord-018089-m94q75xn	79	29	.	.	.
cord-018089-m94q75xn	80	1	PB1	pb1	NN
cord-018089-m94q75xn	80	2	is	be	VBZ
cord-018089-m94q75xn	80	3	an	an	DT
cord-018089-m94q75xn	80	4	endonuclease	endonuclease	NN
cord-018089-m94q75xn	80	5	involved	involve	VBN
cord-018089-m94q75xn	80	6	in	in	IN
cord-018089-m94q75xn	80	7	both	both	DT
cord-018089-m94q75xn	80	8	replication	replication	NN
cord-018089-m94q75xn	80	9	and	and	CC
cord-018089-m94q75xn	80	10	transcription	transcription	NN
cord-018089-m94q75xn	80	11	and	and	CC
cord-018089-m94q75xn	80	12	binds	bind	VBZ
cord-018089-m94q75xn	80	13	the	the	DT
cord-018089-m94q75xn	80	14	promoter	promoter	NN
cord-018089-m94q75xn	80	15	region	region	NN
cord-018089-m94q75xn	80	16	of	of	IN
cord-018089-m94q75xn	80	17	RNA	RNA	NNP
cord-018089-m94q75xn	80	18	segments	segment	NNS
cord-018089-m94q75xn	80	19	[	[	-LRB-
cord-018089-m94q75xn	80	20	40	40	CD
cord-018089-m94q75xn	80	21	]	]	-RRB-
cord-018089-m94q75xn	80	22	.	.	.
cord-018089-m94q75xn	81	1	It	-PRON-	PRP
cord-018089-m94q75xn	81	2	functions	function	VBZ
cord-018089-m94q75xn	81	3	as	as	IN
cord-018089-m94q75xn	81	4	an	an	DT
cord-018089-m94q75xn	81	5	RNA	RNA	NNP
cord-018089-m94q75xn	81	6	-	-	HYPH
cord-018089-m94q75xn	81	7	dependent	dependent	JJ
cord-018089-m94q75xn	81	8	RNA	RNA	NNP
cord-018089-m94q75xn	81	9	polymerase	polymerase	NN
cord-018089-m94q75xn	81	10	and	and	CC
cord-018089-m94q75xn	81	11	catalyzes	catalyze	VBZ
cord-018089-m94q75xn	81	12	RNA	RNA	NNP
cord-018089-m94q75xn	81	13	chain	chain	NN
cord-018089-m94q75xn	81	14	elongation	elongation	NN
cord-018089-m94q75xn	81	15	.	.	.
cord-018089-m94q75xn	82	1	Interaction	Interaction	NNP
cord-018089-m94q75xn	82	2	with	with	IN
cord-018089-m94q75xn	82	3	PA	PA	NNP
cord-018089-m94q75xn	82	4	is	be	VBZ
cord-018089-m94q75xn	82	5	required	require	VBN
cord-018089-m94q75xn	82	6	for	for	IN
cord-018089-m94q75xn	82	7	this	this	DT
cord-018089-m94q75xn	82	8	function	function	NN
cord-018089-m94q75xn	82	9	and	and	CC
cord-018089-m94q75xn	82	10	viral	viral	JJ
cord-018089-m94q75xn	82	11	replication	replication	NN
cord-018089-m94q75xn	82	12	[	[	-LRB-
cord-018089-m94q75xn	82	13	41	41	CD
cord-018089-m94q75xn	82	14	]	]	-RRB-
cord-018089-m94q75xn	82	15	.	.	.
cord-018089-m94q75xn	83	1	PB2	pb2	NN
cord-018089-m94q75xn	83	2	binds	bind	VBZ
cord-018089-m94q75xn	83	3	both	both	DT
cord-018089-m94q75xn	83	4	NP	NP	NNP
cord-018089-m94q75xn	83	5	and	and	CC
cord-018089-m94q75xn	83	6	PB1	pb1	NN
cord-018089-m94q75xn	83	7	via	via	IN
cord-018089-m94q75xn	83	8	separate	separate	JJ
cord-018089-m94q75xn	83	9	binding	binding	NN
cord-018089-m94q75xn	83	10	sites	site	NNS
cord-018089-m94q75xn	83	11	[	[	-LRB-
cord-018089-m94q75xn	83	12	42	42	CD
cord-018089-m94q75xn	83	13	]	]	-RRB-
cord-018089-m94q75xn	83	14	.	.	.
cord-018089-m94q75xn	84	1	Initiation	initiation	NN
cord-018089-m94q75xn	84	2	of	of	IN
cord-018089-m94q75xn	84	3	transcription	transcription	NN
cord-018089-m94q75xn	84	4	is	be	VBZ
cord-018089-m94q75xn	84	5	reliant	reliant	JJ
cord-018089-m94q75xn	84	6	on	on	IN
cord-018089-m94q75xn	84	7	PB2	PB2	NNP
cord-018089-m94q75xn	84	8	,	,	,
cord-018089-m94q75xn	84	9	which	which	WDT
cord-018089-m94q75xn	84	10	binds	bind	VBZ
cord-018089-m94q75xn	84	11	the	the	DT
cord-018089-m94q75xn	84	12	cap	cap	NN
cord-018089-m94q75xn	84	13	on	on	IN
cord-018089-m94q75xn	84	14	host	host	NN
cord-018089-m94q75xn	84	15	pre	pre	NNP
cord-018089-m94q75xn	84	16	-	-	NN
cord-018089-m94q75xn	84	17	mRNA	mRNA	NNP
cord-018089-m94q75xn	84	18	,	,	,
cord-018089-m94q75xn	84	19	and	and	CC
cord-018089-m94q75xn	84	20	this	this	DT
cord-018089-m94q75xn	84	21	cap	cap	NN
cord-018089-m94q75xn	84	22	serves	serve	VBZ
cord-018089-m94q75xn	84	23	as	as	IN
cord-018089-m94q75xn	84	24	a	a	DT
cord-018089-m94q75xn	84	25	primer	primer	NN
cord-018089-m94q75xn	84	26	for	for	IN
cord-018089-m94q75xn	84	27	transcription	transcription	NN
cord-018089-m94q75xn	84	28	[	[	-LRB-
cord-018089-m94q75xn	84	29	43	43	CD
cord-018089-m94q75xn	84	30	,	,	,
cord-018089-m94q75xn	84	31	44	44	CD
cord-018089-m94q75xn	84	32	]	]	-RRB-
cord-018089-m94q75xn	84	33	.	.	.
cord-018089-m94q75xn	85	1	In	in	IN
cord-018089-m94q75xn	85	2	addition	addition	NN
cord-018089-m94q75xn	85	3	,	,	,
cord-018089-m94q75xn	85	4	interactions	interaction	NNS
cord-018089-m94q75xn	85	5	between	between	IN
cord-018089-m94q75xn	85	6	PB2	PB2	NNP
cord-018089-m94q75xn	85	7	and	and	CC
cord-018089-m94q75xn	85	8	host	host	NN
cord-018089-m94q75xn	85	9	proteins	protein	NNS
cord-018089-m94q75xn	85	10	may	may	MD
cord-018089-m94q75xn	85	11	be	be	VB
cord-018089-m94q75xn	85	12	species	specie	NNS
cord-018089-m94q75xn	85	13	specific	specific	JJ
cord-018089-m94q75xn	85	14	and	and	CC
cord-018089-m94q75xn	85	15	potentially	potentially	RB
cord-018089-m94q75xn	85	16	plays	play	VBZ
cord-018089-m94q75xn	85	17	a	a	DT
cord-018089-m94q75xn	85	18	role	role	NN
cord-018089-m94q75xn	85	19	in	in	IN
cord-018089-m94q75xn	85	20	restricting	restrict	VBG
cord-018089-m94q75xn	85	21	host	host	NN
cord-018089-m94q75xn	85	22	range	range	NN
cord-018089-m94q75xn	85	23	Synthesis	Synthesis	NNP
cord-018089-m94q75xn	85	24	of	of	IN
cord-018089-m94q75xn	85	25	mRNA	mRNA	NNP
cord-018089-m94q75xn	85	26	begins	begin	VBZ
cord-018089-m94q75xn	85	27	with	with	IN
cord-018089-m94q75xn	85	28	a	a	DT
cord-018089-m94q75xn	85	29	host	host	NN
cord-018089-m94q75xn	85	30	cell	cell	NN
cord-018089-m94q75xn	85	31	5	5	CD
cord-018089-m94q75xn	85	32	0	0	CD
cord-018089-m94q75xn	86	1	-capped	-capped	JJ
cord-018089-m94q75xn	86	2	primer	primer	NN
cord-018089-m94q75xn	86	3	,	,	,
cord-018089-m94q75xn	86	4	generated	generate	VBN
cord-018089-m94q75xn	86	5	by	by	IN
cord-018089-m94q75xn	86	6	host	host	NN
cord-018089-m94q75xn	86	7	cell	cell	NN
cord-018089-m94q75xn	86	8	RNA	RNA	NNP
cord-018089-m94q75xn	86	9	polymerase	polymerase	NN
cord-018089-m94q75xn	86	10	II	II	NNP
cord-018089-m94q75xn	86	11	and	and	CC
cord-018089-m94q75xn	86	12	obtained	obtain	VBN
cord-018089-m94q75xn	86	13	from	from	IN
cord-018089-m94q75xn	86	14	host	host	NN
cord-018089-m94q75xn	86	15	pre	pre	JJ
cord-018089-m94q75xn	86	16	-	-	JJ
cord-018089-m94q75xn	86	17	mRNA	mrna	JJ
cord-018089-m94q75xn	86	18	[	[	-LRB-
cord-018089-m94q75xn	86	19	44	44	CD
cord-018089-m94q75xn	86	20	]	]	-RRB-
cord-018089-m94q75xn	86	21	.	.	.
cord-018089-m94q75xn	87	1	Transcription	transcription	NN
cord-018089-m94q75xn	87	2	is	be	VBZ
cord-018089-m94q75xn	87	3	thus	thus	RB
cord-018089-m94q75xn	87	4	initiated	initiate	VBN
cord-018089-m94q75xn	87	5	and	and	CC
cord-018089-m94q75xn	87	6	synthesis	synthesis	NN
cord-018089-m94q75xn	87	7	on	on	IN
cord-018089-m94q75xn	87	8	the	the	DT
cord-018089-m94q75xn	87	9	template	template	NN
cord-018089-m94q75xn	87	10	occurs	occur	VBZ
cord-018089-m94q75xn	87	11	in	in	IN
cord-018089-m94q75xn	87	12	a	a	DT
cord-018089-m94q75xn	87	13	3	3	CD
cord-018089-m94q75xn	87	14	0	0	CD
cord-018089-m94q75xn	87	15	to	to	IN
cord-018089-m94q75xn	87	16	5	5	CD
cord-018089-m94q75xn	87	17	0	0	CD
cord-018089-m94q75xn	87	18	direction	direction	NN
cord-018089-m94q75xn	87	19	.	.	.
cord-018089-m94q75xn	88	1	A	a	DT
cord-018089-m94q75xn	88	2	polyadenylation	polyadenylation	NN
cord-018089-m94q75xn	88	3	signal	signal	NN
cord-018089-m94q75xn	88	4	consisting	consist	VBG
cord-018089-m94q75xn	88	5	of	of	IN
cord-018089-m94q75xn	88	6	5	5	CD
cord-018089-m94q75xn	88	7	-	-	SYM
cord-018089-m94q75xn	88	8	7	7	CD
cord-018089-m94q75xn	88	9	uridines	uridine	NNS
cord-018089-m94q75xn	88	10	at	at	IN
cord-018089-m94q75xn	88	11	the	the	DT
cord-018089-m94q75xn	88	12	5	5	CD
cord-018089-m94q75xn	88	13	0	0	CD
cord-018089-m94q75xn	88	14	end	end	NN
cord-018089-m94q75xn	88	15	of	of	IN
cord-018089-m94q75xn	88	16	vRNA	vrna	NN
cord-018089-m94q75xn	88	17	prematurely	prematurely	RB
cord-018089-m94q75xn	88	18	terminates	terminate	VBZ
cord-018089-m94q75xn	88	19	transcription	transcription	NN
cord-018089-m94q75xn	88	20	after	after	IN
cord-018089-m94q75xn	88	21	inducing	induce	VBG
cord-018089-m94q75xn	88	22	stuttering	stutter	VBG
cord-018089-m94q75xn	88	23	of	of	IN
cord-018089-m94q75xn	88	24	the	the	DT
cord-018089-m94q75xn	88	25	viral	viral	JJ
cord-018089-m94q75xn	88	26	polymerase	polymerase	NN
cord-018089-m94q75xn	88	27	[	[	-LRB-
cord-018089-m94q75xn	88	28	48	48	CD
cord-018089-m94q75xn	88	29	]	]	-RRB-
cord-018089-m94q75xn	88	30	[	[	-LRB-
cord-018089-m94q75xn	88	31	49	49	CD
cord-018089-m94q75xn	88	32	]	]	-RRB-
cord-018089-m94q75xn	88	33	[	[	-LRB-
cord-018089-m94q75xn	88	34	50	50	CD
cord-018089-m94q75xn	88	35	]	]	-RRB-
cord-018089-m94q75xn	88	36	.	.	.
cord-018089-m94q75xn	89	1	The	the	DT
cord-018089-m94q75xn	89	2	generation	generation	NN
cord-018089-m94q75xn	89	3	of	of	IN
cord-018089-m94q75xn	89	4	NP	NP	NNP
cord-018089-m94q75xn	89	5	and	and	CC
cord-018089-m94q75xn	89	6	NS1	NS1	NNS
cord-018089-m94q75xn	89	7	tends	tend	VBZ
cord-018089-m94q75xn	89	8	to	to	TO
cord-018089-m94q75xn	89	9	occur	occur	VB
cord-018089-m94q75xn	89	10	earlier	early	RBR
cord-018089-m94q75xn	89	11	after	after	IN
cord-018089-m94q75xn	89	12	infection	infection	NN
cord-018089-m94q75xn	89	13	compared	compare	VBN
cord-018089-m94q75xn	89	14	with	with	IN
cord-018089-m94q75xn	89	15	the	the	DT
cord-018089-m94q75xn	89	16	generation	generation	NN
cord-018089-m94q75xn	89	17	of	of	IN
cord-018089-m94q75xn	89	18	surface	surface	NN
cord-018089-m94q75xn	89	19	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	89	20	and	and	CC
cord-018089-m94q75xn	89	21	M1	M1	NNP
cord-018089-m94q75xn	89	22	mRNAs	mrnas	CD
cord-018089-m94q75xn	89	23	[	[	-LRB-
cord-018089-m94q75xn	89	24	3	3	CD
cord-018089-m94q75xn	89	25	]	]	-RRB-
cord-018089-m94q75xn	89	26	.	.	.
cord-018089-m94q75xn	90	1	Mechanisms	mechanism	NNS
cord-018089-m94q75xn	90	2	for	for	IN
cord-018089-m94q75xn	90	3	the	the	DT
cord-018089-m94q75xn	90	4	regulation	regulation	NN
cord-018089-m94q75xn	90	5	of	of	IN
cord-018089-m94q75xn	90	6	gene	gene	NN
cord-018089-m94q75xn	90	7	expression	expression	NN
cord-018089-m94q75xn	90	8	remain	remain	VBP
cord-018089-m94q75xn	90	9	evasive	evasive	JJ
cord-018089-m94q75xn	90	10	,	,	,
cord-018089-m94q75xn	90	11	although	although	IN
cord-018089-m94q75xn	90	12	NP	NP	NNP
cord-018089-m94q75xn	90	13	has	have	VBZ
cord-018089-m94q75xn	90	14	been	be	VBN
cord-018089-m94q75xn	90	15	implicated	implicate	VBN
cord-018089-m94q75xn	90	16	in	in	IN
cord-018089-m94q75xn	90	17	the	the	DT
cord-018089-m94q75xn	90	18	control	control	NN
cord-018089-m94q75xn	90	19	of	of	IN
cord-018089-m94q75xn	90	20	gene	gene	NN
cord-018089-m94q75xn	90	21	expression	expression	NN
cord-018089-m94q75xn	90	22	[	[	-LRB-
cord-018089-m94q75xn	90	23	51	51	CD
cord-018089-m94q75xn	90	24	]	]	-RRB-
cord-018089-m94q75xn	90	25	.	.	.
cord-018089-m94q75xn	91	1	Viral	viral	JJ
cord-018089-m94q75xn	91	2	replication	replication	NN
cord-018089-m94q75xn	91	3	requires	require	VBZ
cord-018089-m94q75xn	91	4	the	the	DT
cord-018089-m94q75xn	91	5	synthesis	synthesis	NN
cord-018089-m94q75xn	91	6	of	of	IN
cord-018089-m94q75xn	91	7	vRNA	vrna	NN
cord-018089-m94q75xn	91	8	,	,	,
cord-018089-m94q75xn	91	9	which	which	WDT
cord-018089-m94q75xn	91	10	is	be	VBZ
cord-018089-m94q75xn	91	11	primer	primer	NN
cord-018089-m94q75xn	91	12	independent	independent	JJ
cord-018089-m94q75xn	91	13	and	and	CC
cord-018089-m94q75xn	91	14	occurs	occur	VBZ
cord-018089-m94q75xn	91	15	through	through	IN
cord-018089-m94q75xn	91	16	a	a	DT
cord-018089-m94q75xn	91	17	cRNA	crna	JJ
cord-018089-m94q75xn	91	18	intermediate	intermediate	NN
cord-018089-m94q75xn	91	19	.	.	.
cord-018089-m94q75xn	92	1	Nascent	nascent	JJ
cord-018089-m94q75xn	92	2	cRNA	cRNA	NNS
cord-018089-m94q75xn	92	3	is	be	VBZ
cord-018089-m94q75xn	92	4	therefore	therefore	RB
cord-018089-m94q75xn	92	5	not	not	RB
cord-018089-m94q75xn	92	6	capped	cap	VBN
cord-018089-m94q75xn	92	7	or	or	CC
cord-018089-m94q75xn	92	8	polyadenylated	polyadenylate	VBN
cord-018089-m94q75xn	92	9	upon	upon	IN
cord-018089-m94q75xn	92	10	termination	termination	NN
cord-018089-m94q75xn	92	11	.	.	.
cord-018089-m94q75xn	93	1	The	the	DT
cord-018089-m94q75xn	93	2	notion	notion	NN
cord-018089-m94q75xn	93	3	that	that	IN
cord-018089-m94q75xn	93	4	cRNA	cRNA	NNS
cord-018089-m94q75xn	93	5	synthesis	synthesis	NN
cord-018089-m94q75xn	93	6	is	be	VBZ
cord-018089-m94q75xn	93	7	initiated	initiate	VBN
cord-018089-m94q75xn	93	8	after	after	IN
cord-018089-m94q75xn	93	9	a	a	DT
cord-018089-m94q75xn	93	10	switch	switch	NN
cord-018089-m94q75xn	93	11	from	from	IN
cord-018089-m94q75xn	93	12	mRNA	mRNA	NNP
cord-018089-m94q75xn	93	13	synthesis	synthesis	NN
cord-018089-m94q75xn	93	14	has	have	VBZ
cord-018089-m94q75xn	93	15	been	be	VBN
cord-018089-m94q75xn	93	16	challenged	challenge	VBN
cord-018089-m94q75xn	93	17	[	[	-LRB-
cord-018089-m94q75xn	93	18	52	52	CD
cord-018089-m94q75xn	93	19	]	]	-RRB-
cord-018089-m94q75xn	93	20	.	.	.
cord-018089-m94q75xn	94	1	RNP	RNP	NNP
cord-018089-m94q75xn	94	2	complexes	complex	NNS
cord-018089-m94q75xn	94	3	subsequently	subsequently	RB
cord-018089-m94q75xn	94	4	associate	associate	VBP
cord-018089-m94q75xn	94	5	with	with	IN
cord-018089-m94q75xn	94	6	M1	M1	NNP
cord-018089-m94q75xn	94	7	at	at	IN
cord-018089-m94q75xn	94	8	its	-PRON-	PRP$
cord-018089-m94q75xn	94	9	C	c	NN
cord-018089-m94q75xn	94	10	-	-	HYPH
cord-018089-m94q75xn	94	11	terminal	terminal	NN
cord-018089-m94q75xn	94	12	domain	domain	NN
cord-018089-m94q75xn	94	13	,	,	,
cord-018089-m94q75xn	94	14	and	and	CC
cord-018089-m94q75xn	94	15	aggregation	aggregation	NN
cord-018089-m94q75xn	94	16	of	of	IN
cord-018089-m94q75xn	94	17	this	this	DT
cord-018089-m94q75xn	94	18	complex	complex	JJ
cord-018089-m94q75xn	94	19	leads	lead	VBZ
cord-018089-m94q75xn	94	20	to	to	IN
cord-018089-m94q75xn	94	21	inhibition	inhibition	NN
cord-018089-m94q75xn	94	22	of	of	IN
cord-018089-m94q75xn	94	23	transcription	transcription	NN
cord-018089-m94q75xn	94	24	[	[	-LRB-
cord-018089-m94q75xn	94	25	53	53	CD
cord-018089-m94q75xn	94	26	]	]	-RRB-
cord-018089-m94q75xn	94	27	.	.	.
cord-018089-m94q75xn	95	1	M1	M1	NNP
cord-018089-m94q75xn	95	2	also	also	RB
cord-018089-m94q75xn	95	3	interacts	interact	VBZ
cord-018089-m94q75xn	95	4	with	with	IN
cord-018089-m94q75xn	95	5	NEP	NEP	NNP
cord-018089-m94q75xn	95	6	at	at	IN
cord-018089-m94q75xn	95	7	its	-PRON-	PRP$
cord-018089-m94q75xn	95	8	C	c	NN
cord-018089-m94q75xn	95	9	-	-	HYPH
cord-018089-m94q75xn	95	10	terminal	terminal	NN
cord-018089-m94q75xn	95	11	domain	domain	NN
cord-018089-m94q75xn	95	12	[	[	-LRB-
cord-018089-m94q75xn	95	13	38	38	CD
cord-018089-m94q75xn	95	14	,	,	,
cord-018089-m94q75xn	95	15	54	54	CD
cord-018089-m94q75xn	95	16	]	]	-RRB-
cord-018089-m94q75xn	95	17	.	.	.
cord-018089-m94q75xn	96	1	NEP	NEP	NNP
cord-018089-m94q75xn	96	2	,	,	,
cord-018089-m94q75xn	96	3	in	in	IN
cord-018089-m94q75xn	96	4	turn	turn	NN
cord-018089-m94q75xn	96	5	,	,	,
cord-018089-m94q75xn	96	6	associates	associate	NNS
cord-018089-m94q75xn	96	7	with	with	IN
cord-018089-m94q75xn	96	8	host	host	NN
cord-018089-m94q75xn	96	9	nuclear	nuclear	JJ
cord-018089-m94q75xn	96	10	export	export	NN
cord-018089-m94q75xn	96	11	receptor	receptor	NN
cord-018089-m94q75xn	96	12	Crm1	Crm1	NNP
cord-018089-m94q75xn	96	13	via	via	IN
cord-018089-m94q75xn	96	14	the	the	DT
cord-018089-m94q75xn	96	15	NEP	NEP	NNP
cord-018089-m94q75xn	96	16	N	N	NNP
cord-018089-m94q75xn	96	17	-	-	HYPH
cord-018089-m94q75xn	96	18	terminal	terminal	NN
cord-018089-m94q75xn	96	19	domain	domain	NN
cord-018089-m94q75xn	96	20	[	[	-LRB-
cord-018089-m94q75xn	96	21	54	54	CD
cord-018089-m94q75xn	96	22	]	]	-RRB-
cord-018089-m94q75xn	96	23	,	,	,
cord-018089-m94q75xn	96	24	thus	thus	RB
cord-018089-m94q75xn	96	25	orchestrating	orchestrate	VBG
cord-018089-m94q75xn	96	26	the	the	DT
cord-018089-m94q75xn	96	27	export	export	NN
cord-018089-m94q75xn	96	28	of	of	IN
cord-018089-m94q75xn	96	29	viral	viral	JJ
cord-018089-m94q75xn	96	30	RNP	RNP	NNP
cord-018089-m94q75xn	96	31	from	from	IN
cord-018089-m94q75xn	96	32	the	the	DT
cord-018089-m94q75xn	96	33	nucleus	nucleus	NN
cord-018089-m94q75xn	96	34	.	.	.
cord-018089-m94q75xn	97	1	Posttranslational	posttranslational	JJ
cord-018089-m94q75xn	97	2	modification	modification	NN
cord-018089-m94q75xn	97	3	of	of	IN
cord-018089-m94q75xn	97	4	the	the	DT
cord-018089-m94q75xn	97	5	HA	HA	NNP
cord-018089-m94q75xn	97	6	consists	consist	VBZ
cord-018089-m94q75xn	97	7	of	of	IN
cord-018089-m94q75xn	97	8	glycosylation	glycosylation	NN
cord-018089-m94q75xn	97	9	in	in	IN
cord-018089-m94q75xn	97	10	the	the	DT
cord-018089-m94q75xn	97	11	Golgi	Golgi	NNP
cord-018089-m94q75xn	97	12	apparatus	apparatus	NN
cord-018089-m94q75xn	97	13	[	[	-LRB-
cord-018089-m94q75xn	97	14	55	55	CD
cord-018089-m94q75xn	97	15	]	]	-RRB-
cord-018089-m94q75xn	97	16	.	.	.
cord-018089-m94q75xn	98	1	Along	along	IN
cord-018089-m94q75xn	98	2	with	with	IN
cord-018089-m94q75xn	98	3	viral	viral	JJ
cord-018089-m94q75xn	98	4	RNP	RNP	NNP
cord-018089-m94q75xn	98	5	,	,	,
cord-018089-m94q75xn	98	6	protein	protein	NN
cord-018089-m94q75xn	98	7	components	component	NNS
cord-018089-m94q75xn	98	8	of	of	IN
cord-018089-m94q75xn	98	9	the	the	DT
cord-018089-m94q75xn	98	10	virion	virion	NN
cord-018089-m94q75xn	98	11	are	be	VBP
cord-018089-m94q75xn	98	12	coordinately	coordinately	RB
cord-018089-m94q75xn	98	13	trafficked	traffic	VBN
cord-018089-m94q75xn	98	14	to	to	IN
cord-018089-m94q75xn	98	15	the	the	DT
cord-018089-m94q75xn	98	16	apical	apical	JJ
cord-018089-m94q75xn	98	17	surface	surface	NN
cord-018089-m94q75xn	98	18	of	of	IN
cord-018089-m94q75xn	98	19	the	the	DT
cord-018089-m94q75xn	98	20	host	host	NN
cord-018089-m94q75xn	98	21	cell	cell	NN
cord-018089-m94q75xn	98	22	for	for	IN
cord-018089-m94q75xn	98	23	assembly	assembly	NN
cord-018089-m94q75xn	98	24	into	into	IN
cord-018089-m94q75xn	98	25	progeny	progeny	JJ
cord-018089-m94q75xn	98	26	virus	virus	NN
cord-018089-m94q75xn	98	27	.	.	.
cord-018089-m94q75xn	99	1	Two	two	CD
cord-018089-m94q75xn	99	2	models	model	NNS
cord-018089-m94q75xn	99	3	for	for	IN
cord-018089-m94q75xn	99	4	the	the	DT
cord-018089-m94q75xn	99	5	packaging	packaging	NN
cord-018089-m94q75xn	99	6	of	of	IN
cord-018089-m94q75xn	99	7	viral	viral	JJ
cord-018089-m94q75xn	99	8	RNA	RNA	NNP
cord-018089-m94q75xn	99	9	segments	segment	NNS
cord-018089-m94q75xn	99	10	exist	exist	VBP
cord-018089-m94q75xn	99	11	and	and	CC
cord-018089-m94q75xn	99	12	include	include	VBP
cord-018089-m94q75xn	99	13	the	the	DT
cord-018089-m94q75xn	99	14	random	random	JJ
cord-018089-m94q75xn	99	15	incorporation	incorporation	NN
cord-018089-m94q75xn	99	16	[	[	-LRB-
cord-018089-m94q75xn	99	17	56	56	CD
cord-018089-m94q75xn	99	18	,	,	,
cord-018089-m94q75xn	99	19	57	57	CD
cord-018089-m94q75xn	99	20	]	]	-RRB-
cord-018089-m94q75xn	99	21	and	and	CC
cord-018089-m94q75xn	99	22	the	the	DT
cord-018089-m94q75xn	99	23	selective	selective	JJ
cord-018089-m94q75xn	99	24	incorporation	incorporation	NN
cord-018089-m94q75xn	99	25	models	model	NNS
cord-018089-m94q75xn	99	26	[	[	-LRB-
cord-018089-m94q75xn	99	27	58	58	CD
cord-018089-m94q75xn	99	28	,	,	,
cord-018089-m94q75xn	99	29	59	59	CD
cord-018089-m94q75xn	99	30	]	]	-RRB-
cord-018089-m94q75xn	99	31	.	.	.
cord-018089-m94q75xn	100	1	The	the	DT
cord-018089-m94q75xn	100	2	latter	latter	JJ
cord-018089-m94q75xn	100	3	implies	imply	VBZ
cord-018089-m94q75xn	100	4	that	that	IN
cord-018089-m94q75xn	100	5	each	each	DT
cord-018089-m94q75xn	100	6	RNA	RNA	NNP
cord-018089-m94q75xn	100	7	segment	segment	NN
cord-018089-m94q75xn	100	8	possesses	possess	VBZ
cord-018089-m94q75xn	100	9	a	a	DT
cord-018089-m94q75xn	100	10	packaging	packaging	NN
cord-018089-m94q75xn	100	11	signal	signal	NN
cord-018089-m94q75xn	100	12	,	,	,
cord-018089-m94q75xn	100	13	resulting	result	VBG
cord-018089-m94q75xn	100	14	in	in	IN
cord-018089-m94q75xn	100	15	virions	virion	NNS
cord-018089-m94q75xn	100	16	with	with	IN
cord-018089-m94q75xn	100	17	exactly	exactly	RB
cord-018089-m94q75xn	100	18	eight	eight	CD
cord-018089-m94q75xn	100	19	segments	segment	NNS
cord-018089-m94q75xn	100	20	.	.	.
cord-018089-m94q75xn	101	1	Putative	putative	JJ
cord-018089-m94q75xn	101	2	packaging	packaging	NN
cord-018089-m94q75xn	101	3	signals	signal	NNS
cord-018089-m94q75xn	101	4	in	in	IN
cord-018089-m94q75xn	101	5	coding	code	VBG
cord-018089-m94q75xn	101	6	regions	region	NNS
cord-018089-m94q75xn	101	7	of	of	IN
cord-018089-m94q75xn	101	8	polymerase	polymerase	NN
cord-018089-m94q75xn	101	9	genes	gene	NNS
cord-018089-m94q75xn	101	10	,	,	,
cord-018089-m94q75xn	101	11	spike	spike	NN
cord-018089-m94q75xn	101	12	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	101	13	genes	gene	NNS
cord-018089-m94q75xn	101	14	,	,	,
cord-018089-m94q75xn	101	15	and	and	CC
cord-018089-m94q75xn	101	16	the	the	DT
cord-018089-m94q75xn	101	17	NS	NS	NNP
cord-018089-m94q75xn	101	18	gene	gene	NN
cord-018089-m94q75xn	101	19	have	have	VBP
cord-018089-m94q75xn	101	20	been	be	VBN
cord-018089-m94q75xn	101	21	identified	identify	VBN
cord-018089-m94q75xn	101	22	[	[	-LRB-
cord-018089-m94q75xn	101	23	58	58	CD
cord-018089-m94q75xn	101	24	,	,	,
cord-018089-m94q75xn	101	25	[	[	-LRB-
cord-018089-m94q75xn	101	26	60	60	CD
cord-018089-m94q75xn	101	27	]	]	-RRB-
cord-018089-m94q75xn	101	28	[	[	-LRB-
cord-018089-m94q75xn	101	29	61	61	CD
cord-018089-m94q75xn	101	30	]	]	-RRB-
cord-018089-m94q75xn	101	31	[	[	-LRB-
cord-018089-m94q75xn	101	32	62	62	CD
cord-018089-m94q75xn	101	33	]	]	-RRB-
cord-018089-m94q75xn	101	34	[	[	-LRB-
cord-018089-m94q75xn	101	35	63	63	CD
cord-018089-m94q75xn	101	36	]	]	-RRB-
cord-018089-m94q75xn	101	37	.	.	.
cord-018089-m94q75xn	102	1	Viral	Viral	NNP
cord-018089-m94q75xn	102	2	assembly	assembly	NN
cord-018089-m94q75xn	102	3	is	be	VBZ
cord-018089-m94q75xn	102	4	coordinated	coordinate	VBN
cord-018089-m94q75xn	102	5	by	by	IN
cord-018089-m94q75xn	102	6	the	the	DT
cord-018089-m94q75xn	102	7	M1	M1	NNP
cord-018089-m94q75xn	102	8	protein	protein	NN
cord-018089-m94q75xn	102	9	,	,	,
cord-018089-m94q75xn	102	10	which	which	WDT
cord-018089-m94q75xn	102	11	associates	associate	VBZ
cord-018089-m94q75xn	102	12	with	with	IN
cord-018089-m94q75xn	102	13	the	the	DT
cord-018089-m94q75xn	102	14	cytoplasmic	cytoplasmic	JJ
cord-018089-m94q75xn	102	15	tails	tail	NNS
cord-018089-m94q75xn	102	16	of	of	IN
cord-018089-m94q75xn	102	17	the	the	DT
cord-018089-m94q75xn	102	18	viral	viral	JJ
cord-018089-m94q75xn	102	19	glycoproteins	glycoprotein	NNS
cord-018089-m94q75xn	102	20	[	[	-LRB-
cord-018089-m94q75xn	102	21	19	19	CD
cord-018089-m94q75xn	102	22	,	,	,
cord-018089-m94q75xn	102	23	64	64	CD
cord-018089-m94q75xn	102	24	,	,	,
cord-018089-m94q75xn	102	25	65	65	CD
cord-018089-m94q75xn	102	26	]	]	-RRB-
cord-018089-m94q75xn	102	27	,	,	,
cord-018089-m94q75xn	102	28	as	as	RB
cord-018089-m94q75xn	102	29	well	well	RB
cord-018089-m94q75xn	102	30	as	as	IN
cord-018089-m94q75xn	102	31	RNP	RNP	NNP
cord-018089-m94q75xn	102	32	and	and	CC
cord-018089-m94q75xn	102	33	NEP	NEP	NNP
cord-018089-m94q75xn	102	34	,	,	,
cord-018089-m94q75xn	102	35	as	as	IN
cord-018089-m94q75xn	102	36	described	describe	VBN
cord-018089-m94q75xn	102	37	above	above	RB
cord-018089-m94q75xn	102	38	.	.	.
cord-018089-m94q75xn	103	1	Lipid	lipid	NN
cord-018089-m94q75xn	103	2	rafts	raft	NNS
cord-018089-m94q75xn	103	3	navigate	navigate	VBP
cord-018089-m94q75xn	103	4	viral	viral	JJ
cord-018089-m94q75xn	103	5	membrane	membrane	NN
cord-018089-m94q75xn	103	6	glycoproteins	glycoprotein	NNS
cord-018089-m94q75xn	103	7	to	to	IN
cord-018089-m94q75xn	103	8	the	the	DT
cord-018089-m94q75xn	103	9	apical	apical	JJ
cord-018089-m94q75xn	103	10	surface	surface	NN
cord-018089-m94q75xn	103	11	of	of	IN
cord-018089-m94q75xn	103	12	the	the	DT
cord-018089-m94q75xn	103	13	host	host	NN
cord-018089-m94q75xn	103	14	cell	cell	NN
cord-018089-m94q75xn	103	15	[	[	-LRB-
cord-018089-m94q75xn	103	16	66	66	CD
cord-018089-m94q75xn	103	17	,	,	,
cord-018089-m94q75xn	103	18	67	67	CD
cord-018089-m94q75xn	103	19	]	]	-RRB-
cord-018089-m94q75xn	103	20	.	.	.
cord-018089-m94q75xn	104	1	In	in	IN
cord-018089-m94q75xn	104	2	addition	addition	NN
cord-018089-m94q75xn	104	3	,	,	,
cord-018089-m94q75xn	104	4	there	there	EX
cord-018089-m94q75xn	104	5	is	be	VBZ
cord-018089-m94q75xn	104	6	evidence	evidence	NN
cord-018089-m94q75xn	104	7	that	that	IN
cord-018089-m94q75xn	104	8	targeting	target	VBG
cord-018089-m94q75xn	104	9	of	of	IN
cord-018089-m94q75xn	104	10	NP	NP	NNP
cord-018089-m94q75xn	104	11	and	and	CC
cord-018089-m94q75xn	104	12	polymerase	polymerase	NN
cord-018089-m94q75xn	104	13	proteins	protein	NNS
cord-018089-m94q75xn	104	14	to	to	IN
cord-018089-m94q75xn	104	15	the	the	DT
cord-018089-m94q75xn	104	16	apical	apical	JJ
cord-018089-m94q75xn	104	17	surface	surface	NN
cord-018089-m94q75xn	104	18	also	also	RB
cord-018089-m94q75xn	104	19	involves	involve	VBZ
cord-018089-m94q75xn	104	20	lipid	lipid	NN
cord-018089-m94q75xn	104	21	rafts	raft	NNS
cord-018089-m94q75xn	104	22	[	[	-LRB-
cord-018089-m94q75xn	104	23	68	68	CD
cord-018089-m94q75xn	104	24	]	]	-RRB-
cord-018089-m94q75xn	104	25	.	.	.
cord-018089-m94q75xn	105	1	Genomic	genomic	JJ
cord-018089-m94q75xn	105	2	packaging	packaging	NN
cord-018089-m94q75xn	105	3	and	and	CC
cord-018089-m94q75xn	105	4	viral	viral	JJ
cord-018089-m94q75xn	105	5	assembly	assembly	NN
cord-018089-m94q75xn	105	6	occurs	occur	VBZ
cord-018089-m94q75xn	105	7	at	at	IN
cord-018089-m94q75xn	105	8	the	the	DT
cord-018089-m94q75xn	105	9	apical	apical	JJ
cord-018089-m94q75xn	105	10	membrane	membrane	NN
cord-018089-m94q75xn	105	11	and	and	CC
cord-018089-m94q75xn	105	12	is	be	VBZ
cord-018089-m94q75xn	105	13	associated	associate	VBN
cord-018089-m94q75xn	105	14	with	with	IN
cord-018089-m94q75xn	105	15	accumulation	accumulation	NN
cord-018089-m94q75xn	105	16	of	of	IN
cord-018089-m94q75xn	105	17	M1	M1	NNP
cord-018089-m94q75xn	105	18	and	and	CC
cord-018089-m94q75xn	105	19	the	the	DT
cord-018089-m94q75xn	105	20	formation	formation	NN
cord-018089-m94q75xn	105	21	of	of	IN
cord-018089-m94q75xn	105	22	lipid	lipid	NN
cord-018089-m94q75xn	105	23	rafts	raft	NNS
cord-018089-m94q75xn	105	24	.	.	.
cord-018089-m94q75xn	106	1	The	the	DT
cord-018089-m94q75xn	106	2	M1	M1	NNP
cord-018089-m94q75xn	106	3	protein	protein	NN
cord-018089-m94q75xn	106	4	has	have	VBZ
cord-018089-m94q75xn	106	5	also	also	RB
cord-018089-m94q75xn	106	6	been	be	VBN
cord-018089-m94q75xn	106	7	implicated	implicate	VBN
cord-018089-m94q75xn	106	8	in	in	IN
cord-018089-m94q75xn	106	9	viral	viral	JJ
cord-018089-m94q75xn	106	10	morphology	morphology	NN
cord-018089-m94q75xn	106	11	[	[	-LRB-
cord-018089-m94q75xn	106	12	69	69	CD
cord-018089-m94q75xn	106	13	,	,	,
cord-018089-m94q75xn	106	14	70	70	CD
cord-018089-m94q75xn	106	15	]	]	-RRB-
cord-018089-m94q75xn	106	16	.	.	.
cord-018089-m94q75xn	107	1	Because	because	IN
cord-018089-m94q75xn	107	2	the	the	DT
cord-018089-m94q75xn	107	3	HA	HA	NNP
cord-018089-m94q75xn	107	4	binds	bind	VBZ
cord-018089-m94q75xn	107	5	cell	cell	NN
cord-018089-m94q75xn	107	6	surface	surface	NN
cord-018089-m94q75xn	107	7	sialic	sialic	NN
cord-018089-m94q75xn	107	8	acid	acid	NN
cord-018089-m94q75xn	107	9	receptors	receptor	NNS
cord-018089-m94q75xn	107	10	,	,	,
cord-018089-m94q75xn	107	11	virions	virion	NNS
cord-018089-m94q75xn	107	12	must	must	MD
cord-018089-m94q75xn	107	13	be	be	VB
cord-018089-m94q75xn	107	14	released	release	VBN
cord-018089-m94q75xn	107	15	.	.	.
cord-018089-m94q75xn	108	1	The	the	DT
cord-018089-m94q75xn	108	2	NA	NA	NNP
cord-018089-m94q75xn	108	3	functions	function	NNS
cord-018089-m94q75xn	108	4	as	as	IN
cord-018089-m94q75xn	108	5	a	a	DT
cord-018089-m94q75xn	108	6	sialidase	sialidase	NN
cord-018089-m94q75xn	108	7	and	and	CC
cord-018089-m94q75xn	108	8	cleaves	cleave	VBZ
cord-018089-m94q75xn	108	9	sialic	sialic	JJ
cord-018089-m94q75xn	108	10	acids	acid	NNS
cord-018089-m94q75xn	108	11	from	from	IN
cord-018089-m94q75xn	108	12	the	the	DT
cord-018089-m94q75xn	108	13	host	host	NN
cord-018089-m94q75xn	108	14	cell	cell	NN
cord-018089-m94q75xn	108	15	and	and	CC
cord-018089-m94q75xn	108	16	viral	viral	JJ
cord-018089-m94q75xn	108	17	glycoproteins	glycoprotein	NNS
cord-018089-m94q75xn	108	18	to	to	TO
cord-018089-m94q75xn	108	19	minimize	minimize	VB
cord-018089-m94q75xn	108	20	viral	viral	JJ
cord-018089-m94q75xn	108	21	aggregation	aggregation	NN
cord-018089-m94q75xn	108	22	at	at	IN
cord-018089-m94q75xn	108	23	the	the	DT
cord-018089-m94q75xn	108	24	cell	cell	NN
cord-018089-m94q75xn	108	25	surface	surface	NN
cord-018089-m94q75xn	108	26	[	[	-LRB-
cord-018089-m94q75xn	108	27	71	71	CD
cord-018089-m94q75xn	108	28	]	]	-RRB-
cord-018089-m94q75xn	108	29	.	.	.
cord-018089-m94q75xn	109	1	Balance	balance	NN
cord-018089-m94q75xn	109	2	between	between	IN
cord-018089-m94q75xn	109	3	the	the	DT
cord-018089-m94q75xn	109	4	HA	HA	NNP
cord-018089-m94q75xn	109	5	and	and	CC
cord-018089-m94q75xn	109	6	NA	NA	NNP
cord-018089-m94q75xn	109	7	is	be	VBZ
cord-018089-m94q75xn	109	8	thus	thus	RB
cord-018089-m94q75xn	109	9	required	require	VBN
cord-018089-m94q75xn	109	10	for	for	IN
cord-018089-m94q75xn	109	11	optimal	optimal	JJ
cord-018089-m94q75xn	109	12	receptor	receptor	NN
cord-018089-m94q75xn	109	13	binding	binding	NN
cord-018089-m94q75xn	109	14	and	and	CC
cord-018089-m94q75xn	109	15	destruction	destruction	NN
cord-018089-m94q75xn	109	16	[	[	-LRB-
cord-018089-m94q75xn	109	17	64	64	CD
cord-018089-m94q75xn	109	18	,	,	,
cord-018089-m94q75xn	109	19	72	72	CD
cord-018089-m94q75xn	109	20	]	]	-RRB-
cord-018089-m94q75xn	109	21	.	.	.
cord-018089-m94q75xn	110	1	In	in	IN
cord-018089-m94q75xn	110	2	addition	addition	NN
cord-018089-m94q75xn	110	3	to	to	IN
cord-018089-m94q75xn	110	4	its	-PRON-	PRP$
cord-018089-m94q75xn	110	5	receptor	receptor	NN
cord-018089-m94q75xn	110	6	-	-	HYPH
cord-018089-m94q75xn	110	7	destroying	destroy	VBG
cord-018089-m94q75xn	110	8	activity	activity	NN
cord-018089-m94q75xn	110	9	,	,	,
cord-018089-m94q75xn	110	10	NA	NA	NNP
cord-018089-m94q75xn	110	11	is	be	VBZ
cord-018089-m94q75xn	110	12	a	a	DT
cord-018089-m94q75xn	110	13	viral	viral	JJ
cord-018089-m94q75xn	110	14	spike	spike	NN
cord-018089-m94q75xn	110	15	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	110	16	and	and	CC
cord-018089-m94q75xn	110	17	important	important	JJ
cord-018089-m94q75xn	110	18	surface	surface	NN
cord-018089-m94q75xn	110	19	antigen	antigen	NN
cord-018089-m94q75xn	110	20	[	[	-LRB-
cord-018089-m94q75xn	110	21	73	73	CD
cord-018089-m94q75xn	110	22	]	]	-RRB-
cord-018089-m94q75xn	110	23	.	.	.
cord-018089-m94q75xn	111	1	Among	among	IN
cord-018089-m94q75xn	111	2	the	the	DT
cord-018089-m94q75xn	111	3	influenza	influenza	NN
cord-018089-m94q75xn	111	4	virus	virus	NN
cord-018089-m94q75xn	111	5	types	type	NNS
cord-018089-m94q75xn	111	6	,	,	,
cord-018089-m94q75xn	111	7	influenza	influenza	NN
cord-018089-m94q75xn	111	8	A	A	NNP
cord-018089-m94q75xn	111	9	demonstrates	demonstrate	VBZ
cord-018089-m94q75xn	111	10	the	the	DT
cord-018089-m94q75xn	111	11	most	most	RBS
cord-018089-m94q75xn	111	12	genetic	genetic	JJ
cord-018089-m94q75xn	111	13	diversity	diversity	NN
cord-018089-m94q75xn	111	14	and	and	CC
cord-018089-m94q75xn	111	15	is	be	VBZ
cord-018089-m94q75xn	111	16	capable	capable	JJ
cord-018089-m94q75xn	111	17	of	of	IN
cord-018089-m94q75xn	111	18	successfully	successfully	RB
cord-018089-m94q75xn	111	19	infecting	infect	VBG
cord-018089-m94q75xn	111	20	an	an	DT
cord-018089-m94q75xn	111	21	array	array	NN
cord-018089-m94q75xn	111	22	of	of	IN
cord-018089-m94q75xn	111	23	hosts	host	NNS
cord-018089-m94q75xn	111	24	,	,	,
cord-018089-m94q75xn	111	25	including	include	VBG
cord-018089-m94q75xn	111	26	avian	avian	JJ
cord-018089-m94q75xn	111	27	and	and	CC
cord-018089-m94q75xn	111	28	mammalian	mammalian	JJ
cord-018089-m94q75xn	111	29	species	specie	NNS
cord-018089-m94q75xn	111	30	.	.	.
cord-018089-m94q75xn	112	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	112	2	A	a	DT
cord-018089-m94q75xn	112	3	viruses	virus	NNS
cord-018089-m94q75xn	112	4	exhibit	exhibit	VBP
cord-018089-m94q75xn	112	5	an	an	DT
cord-018089-m94q75xn	112	6	evolutionary	evolutionary	JJ
cord-018089-m94q75xn	112	7	pattern	pattern	NN
cord-018089-m94q75xn	112	8	,	,	,
cord-018089-m94q75xn	112	9	which	which	WDT
cord-018089-m94q75xn	112	10	is	be	VBZ
cord-018089-m94q75xn	112	11	complex	complex	JJ
cord-018089-m94q75xn	112	12	and	and	CC
cord-018089-m94q75xn	112	13	consists	consist	VBZ
cord-018089-m94q75xn	112	14	of	of	IN
cord-018089-m94q75xn	112	15	antigenic	antigenic	JJ
cord-018089-m94q75xn	112	16	drift	drift	NN
cord-018089-m94q75xn	112	17	and	and	CC
cord-018089-m94q75xn	112	18	shift	shift	NN
cord-018089-m94q75xn	112	19	.	.	.
cord-018089-m94q75xn	113	1	Drift	drift	NN
cord-018089-m94q75xn	113	2	occurs	occur	VBZ
cord-018089-m94q75xn	113	3	on	on	IN
cord-018089-m94q75xn	113	4	an	an	DT
cord-018089-m94q75xn	113	5	annual	annual	JJ
cord-018089-m94q75xn	113	6	basis	basis	NN
cord-018089-m94q75xn	113	7	and	and	CC
cord-018089-m94q75xn	113	8	has	have	VBZ
cord-018089-m94q75xn	113	9	been	be	VBN
cord-018089-m94q75xn	113	10	attributed	attribute	VBN
cord-018089-m94q75xn	113	11	to	to	IN
cord-018089-m94q75xn	113	12	low	low	JJ
cord-018089-m94q75xn	113	13	fidelity	fidelity	NN
cord-018089-m94q75xn	113	14	of	of	IN
cord-018089-m94q75xn	113	15	the	the	DT
cord-018089-m94q75xn	113	16	RNA	RNA	NNP
cord-018089-m94q75xn	113	17	polymerase	polymerase	NN
cord-018089-m94q75xn	113	18	and	and	CC
cord-018089-m94q75xn	113	19	subsequent	subsequent	JJ
cord-018089-m94q75xn	113	20	selection	selection	NN
cord-018089-m94q75xn	113	21	from	from	IN
cord-018089-m94q75xn	113	22	immune	immune	JJ
cord-018089-m94q75xn	113	23	pressure	pressure	NN
cord-018089-m94q75xn	113	24	exerted	exert	VBN
cord-018089-m94q75xn	113	25	by	by	IN
cord-018089-m94q75xn	113	26	the	the	DT
cord-018089-m94q75xn	113	27	host	host	NN
cord-018089-m94q75xn	113	28	[	[	-LRB-
cord-018089-m94q75xn	113	29	74	74	CD
cord-018089-m94q75xn	113	30	]	]	-RRB-
cord-018089-m94q75xn	113	31	.	.	.
cord-018089-m94q75xn	114	1	This	this	DT
cord-018089-m94q75xn	114	2	results	result	VBZ
cord-018089-m94q75xn	114	3	in	in	IN
cord-018089-m94q75xn	114	4	antigenic	antigenic	JJ
cord-018089-m94q75xn	114	5	diversity	diversity	NN
cord-018089-m94q75xn	114	6	of	of	IN
cord-018089-m94q75xn	114	7	the	the	DT
cord-018089-m94q75xn	114	8	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	114	9	and	and	CC
cord-018089-m94q75xn	114	10	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	114	11	glycoproteins	glycoprotein	NNS
cord-018089-m94q75xn	114	12	and	and	CC
cord-018089-m94q75xn	114	13	is	be	VBZ
cord-018089-m94q75xn	114	14	one	one	CD
cord-018089-m94q75xn	114	15	of	of	IN
cord-018089-m94q75xn	114	16	the	the	DT
cord-018089-m94q75xn	114	17	major	major	JJ
cord-018089-m94q75xn	114	18	challenges	challenge	NNS
cord-018089-m94q75xn	114	19	to	to	IN
cord-018089-m94q75xn	114	20	vaccine	vaccine	NN
cord-018089-m94q75xn	114	21	production	production	NN
cord-018089-m94q75xn	114	22	,	,	,
cord-018089-m94q75xn	114	23	requiring	require	VBG
cord-018089-m94q75xn	114	24	annual	annual	JJ
cord-018089-m94q75xn	114	25	changes	change	NNS
cord-018089-m94q75xn	114	26	to	to	IN
cord-018089-m94q75xn	114	27	vaccine	vaccine	NN
cord-018089-m94q75xn	114	28	components	component	NNS
cord-018089-m94q75xn	114	29	.	.	.
cord-018089-m94q75xn	115	1	The	the	DT
cord-018089-m94q75xn	115	2	HA1	HA1	NNP
cord-018089-m94q75xn	115	3	domain	domain	NN
cord-018089-m94q75xn	115	4	contains	contain	VBZ
cord-018089-m94q75xn	115	5	several	several	JJ
cord-018089-m94q75xn	115	6	epitopes	epitope	NNS
cord-018089-m94q75xn	115	7	and	and	CC
cord-018089-m94q75xn	115	8	is	be	VBZ
cord-018089-m94q75xn	115	9	the	the	DT
cord-018089-m94q75xn	115	10	most	most	RBS
cord-018089-m94q75xn	115	11	dynamic	dynamic	JJ
cord-018089-m94q75xn	115	12	as	as	IN
cord-018089-m94q75xn	115	13	a	a	DT
cord-018089-m94q75xn	115	14	consequence	consequence	NN
cord-018089-m94q75xn	115	15	,	,	,
cord-018089-m94q75xn	115	16	demonstrating	demonstrate	VBG
cord-018089-m94q75xn	115	17	clusters	cluster	NNS
cord-018089-m94q75xn	115	18	of	of	IN
cord-018089-m94q75xn	115	19	antigenic	antigenic	JJ
cord-018089-m94q75xn	115	20	variance	variance	NN
cord-018089-m94q75xn	115	21	over	over	IN
cord-018089-m94q75xn	115	22	time	time	NN
cord-018089-m94q75xn	115	23	[	[	-LRB-
cord-018089-m94q75xn	115	24	75	75	CD
cord-018089-m94q75xn	115	25	]	]	-RRB-
cord-018089-m94q75xn	115	26	.	.	.
cord-018089-m94q75xn	116	1	Antigenic	antigenic	JJ
cord-018089-m94q75xn	116	2	shift	shift	NN
cord-018089-m94q75xn	116	3	results	result	NNS
cord-018089-m94q75xn	116	4	after	after	IN
cord-018089-m94q75xn	116	5	a	a	DT
cord-018089-m94q75xn	116	6	viral	viral	JJ
cord-018089-m94q75xn	116	7	reassortment	reassortment	NN
cord-018089-m94q75xn	116	8	event	event	NN
cord-018089-m94q75xn	116	9	where	where	WRB
cord-018089-m94q75xn	116	10	exchange	exchange	NN
cord-018089-m94q75xn	116	11	of	of	IN
cord-018089-m94q75xn	116	12	one	one	CD
cord-018089-m94q75xn	116	13	or	or	CC
cord-018089-m94q75xn	116	14	more	more	JJR
cord-018089-m94q75xn	116	15	of	of	IN
cord-018089-m94q75xn	116	16	the	the	DT
cord-018089-m94q75xn	116	17	viral	viral	JJ
cord-018089-m94q75xn	116	18	segments	segment	NNS
cord-018089-m94q75xn	116	19	with	with	IN
cord-018089-m94q75xn	116	20	that	that	DT
cord-018089-m94q75xn	116	21	of	of	IN
cord-018089-m94q75xn	116	22	another	another	DT
cord-018089-m94q75xn	116	23	strain	strain	NN
cord-018089-m94q75xn	116	24	may	may	MD
cord-018089-m94q75xn	116	25	result	result	VB
cord-018089-m94q75xn	116	26	in	in	IN
cord-018089-m94q75xn	116	27	a	a	DT
cord-018089-m94q75xn	116	28	novel	novel	JJ
cord-018089-m94q75xn	116	29	serotype	serotype	NN
cord-018089-m94q75xn	116	30	,	,	,
cord-018089-m94q75xn	116	31	potentially	potentially	RB
cord-018089-m94q75xn	116	32	diversifying	diversify	VBG
cord-018089-m94q75xn	116	33	the	the	DT
cord-018089-m94q75xn	116	34	host	host	NN
cord-018089-m94q75xn	116	35	range	range	NN
cord-018089-m94q75xn	116	36	of	of	IN
cord-018089-m94q75xn	116	37	the	the	DT
cord-018089-m94q75xn	116	38	virus	virus	NN
cord-018089-m94q75xn	116	39	.	.	.
cord-018089-m94q75xn	117	1	It	-PRON-	PRP
cord-018089-m94q75xn	117	2	is	be	VBZ
cord-018089-m94q75xn	117	3	in	in	IN
cord-018089-m94q75xn	117	4	this	this	DT
cord-018089-m94q75xn	117	5	setting	setting	NN
cord-018089-m94q75xn	117	6	that	that	WDT
cord-018089-m94q75xn	117	7	pandemic	pandemic	NN
cord-018089-m94q75xn	117	8	strains	strain	NNS
cord-018089-m94q75xn	117	9	have	have	VBP
cord-018089-m94q75xn	117	10	emerged	emerge	VBN
cord-018089-m94q75xn	117	11	in	in	IN
cord-018089-m94q75xn	117	12	immunologically	immunologically	RB
cord-018089-m94q75xn	117	13	naïve	naïve	JJ
cord-018089-m94q75xn	117	14	populations	population	NNS
cord-018089-m94q75xn	117	15	in	in	IN
cord-018089-m94q75xn	117	16	the	the	DT
cord-018089-m94q75xn	117	17	past	past	NN
cord-018089-m94q75xn	117	18	,	,	,
cord-018089-m94q75xn	117	19	including	include	VBG
cord-018089-m94q75xn	117	20	the	the	DT
cord-018089-m94q75xn	117	21	H2N2	H2N2	NNP
cord-018089-m94q75xn	117	22	(	(	-LRB-
cord-018089-m94q75xn	117	23	with	with	IN
cord-018089-m94q75xn	117	24	new	new	JJ
cord-018089-m94q75xn	117	25	HA	HA	NNP
cord-018089-m94q75xn	117	26	,	,	,
cord-018089-m94q75xn	117	27	NA	NA	NNP
cord-018089-m94q75xn	117	28	,	,	,
cord-018089-m94q75xn	117	29	and	and	CC
cord-018089-m94q75xn	117	30	PB1	pb1	NN
cord-018089-m94q75xn	117	31	segment	segment	NN
cord-018089-m94q75xn	117	32	)	)	-RRB-
cord-018089-m94q75xn	117	33	subtype	subtype	NN
cord-018089-m94q75xn	117	34	in	in	IN
cord-018089-m94q75xn	117	35	1957	1957	CD
cord-018089-m94q75xn	117	36	and	and	CC
cord-018089-m94q75xn	117	37	the	the	DT
cord-018089-m94q75xn	117	38	H3N2	H3N2	NNP
cord-018089-m94q75xn	117	39	influenza	influenza	NN
cord-018089-m94q75xn	117	40	virus	virus	NN
cord-018089-m94q75xn	117	41	(	(	-LRB-
cord-018089-m94q75xn	117	42	with	with	IN
cord-018089-m94q75xn	117	43	new	new	JJ
cord-018089-m94q75xn	117	44	HA	HA	NNP
cord-018089-m94q75xn	117	45	and	and	CC
cord-018089-m94q75xn	117	46	PB1	pb1	NN
cord-018089-m94q75xn	117	47	segments	segment	NNS
cord-018089-m94q75xn	117	48	)	)	-RRB-
cord-018089-m94q75xn	117	49	which	which	WDT
cord-018089-m94q75xn	117	50	caused	cause	VBD
cord-018089-m94q75xn	117	51	a	a	DT
cord-018089-m94q75xn	117	52	pandemic	pandemic	NN
cord-018089-m94q75xn	117	53	in	in	IN
cord-018089-m94q75xn	117	54	1968	1968	CD
cord-018089-m94q75xn	117	55	(	(	-LRB-
cord-018089-m94q75xn	117	56	Fig	Fig	NNP
cord-018089-m94q75xn	117	57	.	.	NNP
cord-018089-m94q75xn	117	58	4	4	CD
cord-018089-m94q75xn	117	59	)	)	-RRB-
cord-018089-m94q75xn	117	60	.	.	.
cord-018089-m94q75xn	118	1	Since	since	IN
cord-018089-m94q75xn	118	2	1997	1997	CD
cord-018089-m94q75xn	118	3	,	,	,
cord-018089-m94q75xn	118	4	several	several	JJ
cord-018089-m94q75xn	118	5	avian	avian	JJ
cord-018089-m94q75xn	118	6	influenza	influenza	NN
cord-018089-m94q75xn	118	7	viruses	virus	NNS
cord-018089-m94q75xn	118	8	,	,	,
cord-018089-m94q75xn	118	9	including	include	VBG
cord-018089-m94q75xn	118	10	H5N1	H5N1	NNP
cord-018089-m94q75xn	118	11	,	,	,
cord-018089-m94q75xn	118	12	H7N2	H7N2	NNP
cord-018089-m94q75xn	118	13	,	,	,
cord-018089-m94q75xn	118	14	H7N3	H7N3	NNP
cord-018089-m94q75xn	118	15	,	,	,
cord-018089-m94q75xn	118	16	H7N7	H7N7	NNP
cord-018089-m94q75xn	118	17	,	,	,
cord-018089-m94q75xn	118	18	H9N2	H9N2	NNP
cord-018089-m94q75xn	118	19	,	,	,
cord-018089-m94q75xn	118	20	and	and	CC
cord-018089-m94q75xn	118	21	H10N7	h10n7	RB
cord-018089-m94q75xn	118	22	subtypes	subtype	NNS
cord-018089-m94q75xn	118	23	,	,	,
cord-018089-m94q75xn	118	24	have	have	VBP
cord-018089-m94q75xn	118	25	infected	infect	VBN
cord-018089-m94q75xn	118	26	humans	human	NNS
cord-018089-m94q75xn	118	27	[	[	-LRB-
cord-018089-m94q75xn	118	28	76	76	CD
cord-018089-m94q75xn	118	29	]	]	-RRB-
cord-018089-m94q75xn	118	30	,	,	,
cord-018089-m94q75xn	118	31	though	though	IN
cord-018089-m94q75xn	118	32	limited	limited	JJ
cord-018089-m94q75xn	118	33	evidence	evidence	NN
cord-018089-m94q75xn	118	34	for	for	IN
cord-018089-m94q75xn	118	35	person	person	NN
cord-018089-m94q75xn	118	36	to	to	IN
cord-018089-m94q75xn	118	37	person	person	NN
cord-018089-m94q75xn	118	38	spread	spread	VB
cord-018089-m94q75xn	118	39	exists	exist	VBZ
cord-018089-m94q75xn	118	40	[	[	-LRB-
cord-018089-m94q75xn	118	41	77	77	CD
cord-018089-m94q75xn	118	42	,	,	,
cord-018089-m94q75xn	118	43	78	78	CD
cord-018089-m94q75xn	118	44	]	]	-RRB-
cord-018089-m94q75xn	118	45	.	.	.
cord-018089-m94q75xn	119	1	Lack	lack	NN
cord-018089-m94q75xn	119	2	of	of	IN
cord-018089-m94q75xn	119	3	transmission	transmission	NN
cord-018089-m94q75xn	119	4	among	among	IN
cord-018089-m94q75xn	119	5	humans	human	NNS
cord-018089-m94q75xn	119	6	remains	remain	VBZ
cord-018089-m94q75xn	119	7	a	a	DT
cord-018089-m94q75xn	119	8	barrier	barrier	NN
cord-018089-m94q75xn	119	9	to	to	IN
cord-018089-m94q75xn	119	10	pandemic	pandemic	JJ
cord-018089-m94q75xn	119	11	spread	spread	VBN
cord-018089-m94q75xn	119	12	of	of	IN
cord-018089-m94q75xn	119	13	these	these	DT
cord-018089-m94q75xn	119	14	viruses	virus	NNS
cord-018089-m94q75xn	119	15	.	.	.
cord-018089-m94q75xn	120	1	The	the	DT
cord-018089-m94q75xn	120	2	H5N1	H5N1	NNP
cord-018089-m94q75xn	120	3	subtype	subtype	NN
cord-018089-m94q75xn	120	4	isolated	isolate	VBN
cord-018089-m94q75xn	120	5	from	from	IN
cord-018089-m94q75xn	120	6	avian	avian	JJ
cord-018089-m94q75xn	120	7	species	specie	NNS
cord-018089-m94q75xn	120	8	has	have	VBZ
cord-018089-m94q75xn	120	9	undergone	undergo	VBN
cord-018089-m94q75xn	120	10	genetic	genetic	JJ
cord-018089-m94q75xn	120	11	reassortment	reassortment	NN
cord-018089-m94q75xn	120	12	,	,	,
cord-018089-m94q75xn	120	13	and	and	CC
cord-018089-m94q75xn	120	14	several	several	JJ
cord-018089-m94q75xn	120	15	genotypes	genotype	NNS
cord-018089-m94q75xn	120	16	exist	exist	VBP
cord-018089-m94q75xn	120	17	.	.	.
cord-018089-m94q75xn	121	1	Genotypes	Genotypes	NNP
cord-018089-m94q75xn	121	2	Z	Z	NNP
cord-018089-m94q75xn	121	3	and	and	CC
cord-018089-m94q75xn	121	4	V	v	NN
cord-018089-m94q75xn	121	5	are	be	VBP
cord-018089-m94q75xn	121	6	largely	largely	RB
cord-018089-m94q75xn	121	7	responsible	responsible	JJ
cord-018089-m94q75xn	121	8	for	for	IN
cord-018089-m94q75xn	121	9	outbreaks	outbreak	NNS
cord-018089-m94q75xn	121	10	of	of	IN
cord-018089-m94q75xn	121	11	highly	highly	RB
cord-018089-m94q75xn	121	12	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	121	13	influenza	influenza	NN
cord-018089-m94q75xn	121	14	viruses	virus	NNS
cord-018089-m94q75xn	121	15	(	(	-LRB-
cord-018089-m94q75xn	121	16	HPAI	HPAI	NNP
cord-018089-m94q75xn	121	17	)	)	-RRB-
cord-018089-m94q75xn	121	18	in	in	IN
cord-018089-m94q75xn	121	19	domestic	domestic	JJ
cord-018089-m94q75xn	121	20	birds	bird	NNS
cord-018089-m94q75xn	121	21	in	in	IN
cord-018089-m94q75xn	121	22	Southeast	Southeast	NNP
cord-018089-m94q75xn	121	23	Asia	Asia	NNP
cord-018089-m94q75xn	121	24	beginning	begin	VBG
cord-018089-m94q75xn	121	25	in	in	IN
cord-018089-m94q75xn	121	26	2003	2003	CD
cord-018089-m94q75xn	121	27	[	[	-LRB-
cord-018089-m94q75xn	121	28	77	77	CD
cord-018089-m94q75xn	121	29	]	]	-RRB-
cord-018089-m94q75xn	121	30	.	.	.
cord-018089-m94q75xn	122	1	H5N1	H5N1	NNP
cord-018089-m94q75xn	122	2	viruses	virus	NNS
cord-018089-m94q75xn	122	3	may	may	MD
cord-018089-m94q75xn	122	4	also	also	RB
cord-018089-m94q75xn	122	5	be	be	VB
cord-018089-m94q75xn	122	6	divided	divide	VBN
cord-018089-m94q75xn	122	7	into	into	IN
cord-018089-m94q75xn	122	8	clades	clade	NNS
cord-018089-m94q75xn	122	9	based	base	VBN
cord-018089-m94q75xn	122	10	on	on	IN
cord-018089-m94q75xn	122	11	the	the	DT
cord-018089-m94q75xn	122	12	genomic	genomic	JJ
cord-018089-m94q75xn	122	13	analysis	analysis	NN
cord-018089-m94q75xn	122	14	of	of	IN
cord-018089-m94q75xn	122	15	the	the	DT
cord-018089-m94q75xn	122	16	HA	HA	NNP
cord-018089-m94q75xn	122	17	genes	gene	NNS
cord-018089-m94q75xn	122	18	,	,	,
cord-018089-m94q75xn	122	19	and	and	CC
cord-018089-m94q75xn	122	20	clade	clade	NN
cord-018089-m94q75xn	122	21	2	2	CD
cord-018089-m94q75xn	122	22	is	be	VBZ
cord-018089-m94q75xn	122	23	further	further	RB
cord-018089-m94q75xn	122	24	divided	divide	VBN
cord-018089-m94q75xn	122	25	into	into	IN
cord-018089-m94q75xn	122	26	subclades	subclade	NNS
cord-018089-m94q75xn	122	27	;	;	:
cord-018089-m94q75xn	122	28	up	up	IN
cord-018089-m94q75xn	122	29	to	to	TO
cord-018089-m94q75xn	122	30	ten	ten	CD
cord-018089-m94q75xn	122	31	clades	clade	NNS
cord-018089-m94q75xn	122	32	have	have	VBP
cord-018089-m94q75xn	122	33	been	be	VBN
cord-018089-m94q75xn	122	34	identified	identify	VBN
cord-018089-m94q75xn	122	35	in	in	IN
cord-018089-m94q75xn	122	36	avian	avian	JJ
cord-018089-m94q75xn	122	37	species	specie	NNS
cord-018089-m94q75xn	122	38	,	,	,
cord-018089-m94q75xn	122	39	four	four	CD
cord-018089-m94q75xn	122	40	of	of	IN
cord-018089-m94q75xn	122	41	which	which	WDT
cord-018089-m94q75xn	122	42	have	have	VBP
cord-018089-m94q75xn	122	43	infected	infect	VBN
cord-018089-m94q75xn	122	44	humans	human	NNS
cord-018089-m94q75xn	122	45	[	[	-LRB-
cord-018089-m94q75xn	122	46	79	79	CD
cord-018089-m94q75xn	122	47	,	,	,
cord-018089-m94q75xn	122	48	80	80	CD
cord-018089-m94q75xn	122	49	]	]	-RRB-
cord-018089-m94q75xn	122	50	.	.	.
cord-018089-m94q75xn	123	1	Less	Less	JJR
cord-018089-m94q75xn	123	2	than	than	IN
cord-018089-m94q75xn	123	3	1	1	CD
cord-018089-m94q75xn	123	4	%	%	NN
cord-018089-m94q75xn	123	5	divergence	divergence	NN
cord-018089-m94q75xn	123	6	from	from	IN
cord-018089-m94q75xn	123	7	avian	avian	JJ
cord-018089-m94q75xn	123	8	isolates	isolate	NNS
cord-018089-m94q75xn	123	9	has	have	VBZ
cord-018089-m94q75xn	123	10	been	be	VBN
cord-018089-m94q75xn	123	11	reported	report	VBN
cord-018089-m94q75xn	123	12	in	in	IN
cord-018089-m94q75xn	123	13	viruses	virus	NNS
cord-018089-m94q75xn	123	14	isolated	isolate	VBN
cord-018089-m94q75xn	123	15	from	from	IN
cord-018089-m94q75xn	123	16	humans	human	NNS
cord-018089-m94q75xn	123	17	in	in	IN
cord-018089-m94q75xn	123	18	Asia	Asia	NNP
cord-018089-m94q75xn	123	19	[	[	-LRB-
cord-018089-m94q75xn	123	20	7	7	CD
cord-018089-m94q75xn	123	21	]	]	-RRB-
cord-018089-m94q75xn	123	22	.	.	.
cord-018089-m94q75xn	124	1	The	the	DT
cord-018089-m94q75xn	124	2	pandemic	pandemic	NN
cord-018089-m94q75xn	124	3	influenza	influenza	NN
cord-018089-m94q75xn	124	4	A	a	NN
cord-018089-m94q75xn	124	5	(	(	-LRB-
cord-018089-m94q75xn	124	6	H1N1	H1N1	NNP
cord-018089-m94q75xn	124	7	)	)	-RRB-
cord-018089-m94q75xn	124	8	2009	2009	CD
cord-018089-m94q75xn	124	9	virus	virus	NN
cord-018089-m94q75xn	124	10	has	have	VBZ
cord-018089-m94q75xn	124	11	been	be	VBN
cord-018089-m94q75xn	124	12	described	describe	VBN
cord-018089-m94q75xn	124	13	as	as	IN
cord-018089-m94q75xn	124	14	a	a	DT
cord-018089-m94q75xn	124	15	"	"	``
cord-018089-m94q75xn	124	16	triple	triple	JJ
cord-018089-m94q75xn	124	17	reassortant	reassortant	NN
cord-018089-m94q75xn	124	18	"	"	''
cord-018089-m94q75xn	124	19	of	of	IN
cord-018089-m94q75xn	124	20	swine	swine	NN
cord-018089-m94q75xn	124	21	,	,	,
cord-018089-m94q75xn	124	22	human	human	NN
cord-018089-m94q75xn	124	23	,	,	,
cord-018089-m94q75xn	124	24	and	and	CC
cord-018089-m94q75xn	124	25	avian	avian	JJ
cord-018089-m94q75xn	124	26	influenza	influenza	NN
cord-018089-m94q75xn	124	27	viruses	virus	NNS
cord-018089-m94q75xn	124	28	;	;	:
cord-018089-m94q75xn	124	29	the	the	DT
cord-018089-m94q75xn	124	30	H1	H1	NNP
cord-018089-m94q75xn	124	31	gene	gene	NN
cord-018089-m94q75xn	124	32	from	from	IN
cord-018089-m94q75xn	124	33	this	this	DT
cord-018089-m94q75xn	124	34	virus	virus	NN
cord-018089-m94q75xn	124	35	has	have	VBZ
cord-018089-m94q75xn	124	36	been	be	VBN
cord-018089-m94q75xn	124	37	circulating	circulate	VBG
cord-018089-m94q75xn	124	38	among	among	IN
cord-018089-m94q75xn	124	39	swine	swine	NN
cord-018089-m94q75xn	124	40	for	for	IN
cord-018089-m94q75xn	124	41	decades	decade	NNS
cord-018089-m94q75xn	124	42	,	,	,
cord-018089-m94q75xn	124	43	with	with	IN
cord-018089-m94q75xn	124	44	limited	limited	JJ
cord-018089-m94q75xn	124	45	drift	drift	NN
cord-018089-m94q75xn	124	46	compared	compare	VBN
cord-018089-m94q75xn	124	47	with	with	IN
cord-018089-m94q75xn	124	48	genes	gene	NNS
cord-018089-m94q75xn	124	49	of	of	IN
cord-018089-m94q75xn	124	50	H1	h1	NN
cord-018089-m94q75xn	124	51	viruses	virus	NNS
cord-018089-m94q75xn	124	52	that	that	WDT
cord-018089-m94q75xn	124	53	have	have	VBP
cord-018089-m94q75xn	124	54	been	be	VBN
cord-018089-m94q75xn	124	55	circulating	circulate	VBG
cord-018089-m94q75xn	124	56	in	in	IN
cord-018089-m94q75xn	124	57	humans	human	NNS
cord-018089-m94q75xn	124	58	,	,	,
cord-018089-m94q75xn	124	59	and	and	CC
cord-018089-m94q75xn	124	60	is	be	VBZ
cord-018089-m94q75xn	124	61	thus	thus	RB
cord-018089-m94q75xn	124	62	antigenically	antigenically	RB
cord-018089-m94q75xn	124	63	different	different	JJ
cord-018089-m94q75xn	124	64	from	from	IN
cord-018089-m94q75xn	124	65	seasonal	seasonal	JJ
cord-018089-m94q75xn	124	66	human	human	JJ
cord-018089-m94q75xn	124	67	H1N1	H1N1	NNP
cord-018089-m94q75xn	124	68	viruses	virus	NNS
cord-018089-m94q75xn	124	69	.	.	.
cord-018089-m94q75xn	125	1	The	the	DT
cord-018089-m94q75xn	125	2	pandemic	pandemic	NN
cord-018089-m94q75xn	125	3	influenza	influenza	NN
cord-018089-m94q75xn	125	4	A	a	NN
cord-018089-m94q75xn	125	5	(	(	-LRB-
cord-018089-m94q75xn	125	6	H1N1	H1N1	NNP
cord-018089-m94q75xn	125	7	)	)	-RRB-
cord-018089-m94q75xn	126	1	2009	2009	CD
cord-018089-m94q75xn	126	2	virus	virus	NN
cord-018089-m94q75xn	126	3	is	be	VBZ
cord-018089-m94q75xn	126	4	composed	compose	VBN
cord-018089-m94q75xn	126	5	of	of	IN
cord-018089-m94q75xn	126	6	six	six	CD
cord-018089-m94q75xn	126	7	segments	segment	NNS
cord-018089-m94q75xn	126	8	from	from	IN
cord-018089-m94q75xn	126	9	the	the	DT
cord-018089-m94q75xn	126	10	triple	triple	JJ
cord-018089-m94q75xn	126	11	reassortant	reassortant	NN
cord-018089-m94q75xn	126	12	,	,	,
cord-018089-m94q75xn	126	13	including	include	VBG
cord-018089-m94q75xn	126	14	a	a	DT
cord-018089-m94q75xn	126	15	human	human	JJ
cord-018089-m94q75xn	126	16	PB1	pb1	NN
cord-018089-m94q75xn	126	17	segment	segment	NN
cord-018089-m94q75xn	126	18	,	,	,
cord-018089-m94q75xn	126	19	classical	classical	JJ
cord-018089-m94q75xn	126	20	swine	swine	NN
cord-018089-m94q75xn	126	21	-	-	HYPH
cord-018089-m94q75xn	126	22	origin	origin	NN
cord-018089-m94q75xn	126	23	HA	HA	NNP
cord-018089-m94q75xn	126	24	,	,	,
cord-018089-m94q75xn	126	25	NP	NP	NNP
cord-018089-m94q75xn	126	26	,	,	,
cord-018089-m94q75xn	126	27	and	and	CC
cord-018089-m94q75xn	126	28	NS	NS	NNP
cord-018089-m94q75xn	126	29	,	,	,
cord-018089-m94q75xn	126	30	and	and	CC
cord-018089-m94q75xn	126	31	avian	avian	JJ
cord-018089-m94q75xn	126	32	-	-	HYPH
cord-018089-m94q75xn	126	33	origin	origin	NN
cord-018089-m94q75xn	126	34	PB2	PB2	NNP
cord-018089-m94q75xn	126	35	and	and	CC
cord-018089-m94q75xn	126	36	PA	PA	NNP
cord-018089-m94q75xn	126	37	segments	segment	NNS
cord-018089-m94q75xn	126	38	that	that	WDT
cord-018089-m94q75xn	126	39	have	have	VBP
cord-018089-m94q75xn	126	40	been	be	VBN
cord-018089-m94q75xn	126	41	circulating	circulate	VBG
cord-018089-m94q75xn	126	42	in	in	IN
cord-018089-m94q75xn	126	43	swine	swine	NN
cord-018089-m94q75xn	126	44	since	since	IN
cord-018089-m94q75xn	126	45	approximately	approximately	RB
cord-018089-m94q75xn	126	46	1998	1998	CD
cord-018089-m94q75xn	126	47	.	.	.
cord-018089-m94q75xn	127	1	The	the	DT
cord-018089-m94q75xn	127	2	NA	NA	NNP
cord-018089-m94q75xn	127	3	and	and	CC
cord-018089-m94q75xn	127	4	M	M	NNP
cord-018089-m94q75xn	127	5	segments	segment	NNS
cord-018089-m94q75xn	127	6	originate	originate	VBP
cord-018089-m94q75xn	127	7	from	from	IN
cord-018089-m94q75xn	127	8	a	a	DT
cord-018089-m94q75xn	127	9	Eurasian	eurasian	JJ
cord-018089-m94q75xn	127	10	lineage	lineage	NN
cord-018089-m94q75xn	127	11	of	of	IN
cord-018089-m94q75xn	127	12	swine	swine	NN
cord-018089-m94q75xn	127	13	influenza	influenza	NN
cord-018089-m94q75xn	127	14	viruses	virus	NNS
cord-018089-m94q75xn	127	15	[	[	-LRB-
cord-018089-m94q75xn	127	16	1	1	CD
cord-018089-m94q75xn	127	17	,	,	,
cord-018089-m94q75xn	127	18	2	2	CD
cord-018089-m94q75xn	127	19	,	,	,
cord-018089-m94q75xn	127	20	81	81	CD
cord-018089-m94q75xn	127	21	]	]	-RRB-
cord-018089-m94q75xn	128	1	(	(	-LRB-
cord-018089-m94q75xn	128	2	Fig	Fig	NNP
cord-018089-m94q75xn	128	3	.	.	.
cord-018089-m94q75xn	129	1	5	5	LS
cord-018089-m94q75xn	129	2	)	)	-RRB-
cord-018089-m94q75xn	129	3	.	.	.
cord-018089-m94q75xn	130	1	In	in	IN
cord-018089-m94q75xn	130	2	order	order	NN
cord-018089-m94q75xn	130	3	to	to	TO
cord-018089-m94q75xn	130	4	tackle	tackle	VB
cord-018089-m94q75xn	130	5	the	the	DT
cord-018089-m94q75xn	130	6	challenge	challenge	NN
cord-018089-m94q75xn	130	7	of	of	IN
cord-018089-m94q75xn	130	8	understanding	understand	VBG
cord-018089-m94q75xn	130	9	the	the	DT
cord-018089-m94q75xn	130	10	evolution	evolution	NN
cord-018089-m94q75xn	130	11	of	of	IN
cord-018089-m94q75xn	130	12	influenza	influenza	NN
cord-018089-m94q75xn	130	13	virus	virus	NN
cord-018089-m94q75xn	130	14	,	,	,
cord-018089-m94q75xn	130	15	large	large	JJ
cord-018089-m94q75xn	130	16	-	-	HYPH
cord-018089-m94q75xn	130	17	scale	scale	NN
cord-018089-m94q75xn	130	18	collaborative	collaborative	JJ
cord-018089-m94q75xn	130	19	efforts	effort	NNS
cord-018089-m94q75xn	130	20	such	such	JJ
cord-018089-m94q75xn	130	21	as	as	IN
cord-018089-m94q75xn	130	22	the	the	DT
cord-018089-m94q75xn	130	23	Influenza	Influenza	NNP
cord-018089-m94q75xn	130	24	Genome	Genome	NNP
cord-018089-m94q75xn	130	25	Sequencing	Sequencing	NNP
cord-018089-m94q75xn	130	26	Project	Project	NNP
cord-018089-m94q75xn	130	27	have	have	VBP
cord-018089-m94q75xn	130	28	been	be	VBN
cord-018089-m94q75xn	130	29	undertaken	undertake	VBN
cord-018089-m94q75xn	130	30	.	.	.
cord-018089-m94q75xn	131	1	The	the	DT
cord-018089-m94q75xn	131	2	presence	presence	NN
cord-018089-m94q75xn	131	3	of	of	IN
cord-018089-m94q75xn	131	4	several	several	JJ
cord-018089-m94q75xn	131	5	cocirculating	cocirculate	VBG
cord-018089-m94q75xn	131	6	clades	clade	NNS
cord-018089-m94q75xn	131	7	in	in	IN
cord-018089-m94q75xn	131	8	the	the	DT
cord-018089-m94q75xn	131	9	human	human	JJ
cord-018089-m94q75xn	131	10	population	population	NN
cord-018089-m94q75xn	131	11	has	have	VBZ
cord-018089-m94q75xn	131	12	been	be	VBN
cord-018089-m94q75xn	131	13	described	describe	VBN
cord-018089-m94q75xn	131	14	,	,	,
cord-018089-m94q75xn	131	15	accounting	account	VBG
cord-018089-m94q75xn	131	16	for	for	IN
cord-018089-m94q75xn	131	17	reassortment	reassortment	NN
cord-018089-m94q75xn	131	18	.	.	.
cord-018089-m94q75xn	132	1	This	this	DT
cord-018089-m94q75xn	132	2	can	can	MD
cord-018089-m94q75xn	132	3	result	result	VB
cord-018089-m94q75xn	132	4	in	in	IN
cord-018089-m94q75xn	132	5	limited	limited	JJ
cord-018089-m94q75xn	132	6	vaccine	vaccine	NN
cord-018089-m94q75xn	132	7	effectiveness	effectiveness	NN
cord-018089-m94q75xn	132	8	,	,	,
cord-018089-m94q75xn	132	9	as	as	IN
cord-018089-m94q75xn	132	10	seen	see	VBN
cord-018089-m94q75xn	132	11	with	with	IN
cord-018089-m94q75xn	132	12	A	A	NNP
cord-018089-m94q75xn	132	13	/	/	SYM
cord-018089-m94q75xn	132	14	Fujian/411/2002-like	Fujian/411/2002-like	NNP
cord-018089-m94q75xn	132	15	virus	virus	NN
cord-018089-m94q75xn	132	16	during	during	IN
cord-018089-m94q75xn	132	17	the	the	DT
cord-018089-m94q75xn	132	18	2003	2003	CD
cord-018089-m94q75xn	132	19	-	-	SYM
cord-018089-m94q75xn	132	20	2004	2004	CD
cord-018089-m94q75xn	132	21	season	season	NN
cord-018089-m94q75xn	132	22	[	[	-LRB-
cord-018089-m94q75xn	132	23	8	8	CD
cord-018089-m94q75xn	132	24	]	]	-RRB-
cord-018089-m94q75xn	132	25	.	.	.
cord-018089-m94q75xn	133	1	Genetic	genetic	JJ
cord-018089-m94q75xn	133	2	evolution	evolution	NN
cord-018089-m94q75xn	133	3	appears	appear	VBZ
cord-018089-m94q75xn	133	4	to	to	TO
cord-018089-m94q75xn	133	5	be	be	VB
cord-018089-m94q75xn	133	6	a	a	DT
cord-018089-m94q75xn	133	7	relatively	relatively	RB
cord-018089-m94q75xn	133	8	gradual	gradual	JJ
cord-018089-m94q75xn	133	9	process	process	NN
cord-018089-m94q75xn	133	10	;	;	:
cord-018089-m94q75xn	133	11	however	however	RB
cord-018089-m94q75xn	133	12	,	,	,
cord-018089-m94q75xn	133	13	antigenic	antigenic	JJ
cord-018089-m94q75xn	133	14	changes	change	NNS
cord-018089-m94q75xn	133	15	in	in	IN
cord-018089-m94q75xn	133	16	the	the	DT
cord-018089-m94q75xn	133	17	HA1	HA1	NNP
cord-018089-m94q75xn	133	18	domain	domain	NN
cord-018089-m94q75xn	133	19	tend	tend	VBP
cord-018089-m94q75xn	133	20	to	to	TO
cord-018089-m94q75xn	133	21	cluster	cluster	VB
cord-018089-m94q75xn	133	22	[	[	-LRB-
cord-018089-m94q75xn	133	23	75	75	CD
cord-018089-m94q75xn	133	24	]	]	-RRB-
cord-018089-m94q75xn	133	25	.	.	.
cord-018089-m94q75xn	134	1	Ongoing	ongoing	JJ
cord-018089-m94q75xn	134	2	changes	change	NNS
cord-018089-m94q75xn	134	3	of	of	IN
cord-018089-m94q75xn	134	4	the	the	DT
cord-018089-m94q75xn	134	5	H3	H3	NNP
cord-018089-m94q75xn	134	6	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	134	7	in	in	IN
cord-018089-m94q75xn	134	8	the	the	DT
cord-018089-m94q75xn	134	9	human	human	JJ
cord-018089-m94q75xn	134	10	population	population	NN
cord-018089-m94q75xn	134	11	result	result	VBP
cord-018089-m94q75xn	134	12	from	from	IN
cord-018089-m94q75xn	134	13	selective	selective	JJ
cord-018089-m94q75xn	134	14	pressure	pressure	NN
cord-018089-m94q75xn	134	15	exerted	exert	VBN
cord-018089-m94q75xn	134	16	by	by	IN
cord-018089-m94q75xn	134	17	the	the	DT
cord-018089-m94q75xn	134	18	host	host	NN
cord-018089-m94q75xn	134	19	immune	immune	JJ
cord-018089-m94q75xn	134	20	system	system	NN
cord-018089-m94q75xn	134	21	.	.	.
cord-018089-m94q75xn	135	1	In	in	IN
cord-018089-m94q75xn	135	2	contrast	contrast	NN
cord-018089-m94q75xn	135	3	,	,	,
cord-018089-m94q75xn	135	4	the	the	DT
cord-018089-m94q75xn	135	5	H3	H3	NNP
cord-018089-m94q75xn	135	6	lineage	lineage	NN
cord-018089-m94q75xn	135	7	in	in	IN
cord-018089-m94q75xn	135	8	birds	bird	NNS
cord-018089-m94q75xn	135	9	has	have	VBZ
cord-018089-m94q75xn	135	10	remained	remain	VBN
cord-018089-m94q75xn	135	11	relatively	relatively	RB
cord-018089-m94q75xn	135	12	stable	stable	JJ
cord-018089-m94q75xn	135	13	[	[	-LRB-
cord-018089-m94q75xn	135	14	82	82	CD
cord-018089-m94q75xn	135	15	]	]	-RRB-
cord-018089-m94q75xn	135	16	.	.	.
cord-018089-m94q75xn	136	1	The	the	DT
cord-018089-m94q75xn	136	2	rate	rate	NN
cord-018089-m94q75xn	136	3	of	of	IN
cord-018089-m94q75xn	136	4	change	change	NN
cord-018089-m94q75xn	136	5	of	of	IN
cord-018089-m94q75xn	136	6	the	the	DT
cord-018089-m94q75xn	136	7	H3	H3	NNP
cord-018089-m94q75xn	136	8	subtype	subtype	NN
cord-018089-m94q75xn	136	9	is	be	VBZ
cord-018089-m94q75xn	136	10	greater	great	JJR
cord-018089-m94q75xn	136	11	when	when	WRB
cord-018089-m94q75xn	136	12	compared	compare	VBN
cord-018089-m94q75xn	136	13	with	with	IN
cord-018089-m94q75xn	136	14	H1	H1	NNP
cord-018089-m94q75xn	136	15	viruses	virus	NNS
cord-018089-m94q75xn	136	16	and	and	CC
cord-018089-m94q75xn	136	17	influenza	influenza	NN
cord-018089-m94q75xn	136	18	B	b	NN
cord-018089-m94q75xn	136	19	,	,	,
cord-018089-m94q75xn	136	20	with	with	IN
cord-018089-m94q75xn	136	21	estimated	estimate	VBN
cord-018089-m94q75xn	136	22	nucleotide	nucleotide	JJ
cord-018089-m94q75xn	136	23	changes	change	NNS
cord-018089-m94q75xn	136	24	per	per	IN
cord-018089-m94q75xn	136	25	site	site	NN
cord-018089-m94q75xn	136	26	per	per	IN
cord-018089-m94q75xn	136	27	year	year	NN
cord-018089-m94q75xn	136	28	of	of	IN
cord-018089-m94q75xn	136	29	0.0037	0.0037	CD
cord-018089-m94q75xn	136	30	for	for	IN
cord-018089-m94q75xn	136	31	H3	H3	NNP
cord-018089-m94q75xn	136	32	,	,	,
cord-018089-m94q75xn	136	33	0.0018	0.0018	CD
cord-018089-m94q75xn	136	34	for	for	IN
cord-018089-m94q75xn	136	35	H1	h1	NN
cord-018089-m94q75xn	136	36	,	,	,
cord-018089-m94q75xn	136	37	and	and	CC
cord-018089-m94q75xn	136	38	0.0013	0.0013	CD
cord-018089-m94q75xn	136	39	for	for	IN
cord-018089-m94q75xn	136	40	influenza	influenza	NN
cord-018089-m94q75xn	136	41	B	b	NN
cord-018089-m94q75xn	136	42	[	[	-LRB-
cord-018089-m94q75xn	136	43	83	83	CD
cord-018089-m94q75xn	136	44	]	]	-RRB-
cord-018089-m94q75xn	136	45	.	.	.
cord-018089-m94q75xn	137	1	As	as	IN
cord-018089-m94q75xn	137	2	greater	great	JJR
cord-018089-m94q75xn	137	3	numbers	number	NNS
cord-018089-m94q75xn	137	4	of	of	IN
cord-018089-m94q75xn	137	5	influenza	influenza	NN
cord-018089-m94q75xn	137	6	virus	virus	NN
cord-018089-m94q75xn	137	7	genome	genome	NN
cord-018089-m94q75xn	137	8	sequences	sequence	NNS
cord-018089-m94q75xn	137	9	become	become	VBP
cord-018089-m94q75xn	137	10	available	available	JJ
cord-018089-m94q75xn	137	11	and	and	CC
cord-018089-m94q75xn	137	12	we	-PRON-	PRP
cord-018089-m94q75xn	137	13	gain	gain	VBP
cord-018089-m94q75xn	137	14	insight	insight	NN
cord-018089-m94q75xn	137	15	into	into	IN
cord-018089-m94q75xn	137	16	antigenic	antigenic	JJ
cord-018089-m94q75xn	137	17	patterns	pattern	NNS
cord-018089-m94q75xn	137	18	of	of	IN
cord-018089-m94q75xn	137	19	change	change	NN
cord-018089-m94q75xn	137	20	,	,	,
cord-018089-m94q75xn	137	21	this	this	DT
cord-018089-m94q75xn	137	22	knowledge	knowledge	NN
cord-018089-m94q75xn	137	23	may	may	MD
cord-018089-m94q75xn	137	24	be	be	VB
cord-018089-m94q75xn	137	25	applied	apply	VBN
cord-018089-m94q75xn	137	26	to	to	IN
cord-018089-m94q75xn	137	27	annual	annual	JJ
cord-018089-m94q75xn	137	28	vaccine	vaccine	NN
cord-018089-m94q75xn	137	29	development	development	NN
cord-018089-m94q75xn	137	30	.	.	.
cord-018089-m94q75xn	138	1	Prediction	prediction	NN
cord-018089-m94q75xn	138	2	of	of	IN
cord-018089-m94q75xn	138	3	future	future	JJ
cord-018089-m94q75xn	138	4	influenza	influenza	NN
cord-018089-m94q75xn	138	5	sequences	sequence	NNS
cord-018089-m94q75xn	138	6	could	could	MD
cord-018089-m94q75xn	138	7	lead	lead	VB
cord-018089-m94q75xn	138	8	to	to	IN
cord-018089-m94q75xn	138	9	more	more	RBR
cord-018089-m94q75xn	138	10	timely	timely	JJ
cord-018089-m94q75xn	138	11	development	development	NN
cord-018089-m94q75xn	138	12	of	of	IN
cord-018089-m94q75xn	138	13	effective	effective	JJ
cord-018089-m94q75xn	138	14	vaccines	vaccine	NNS
cord-018089-m94q75xn	138	15	[	[	-LRB-
cord-018089-m94q75xn	138	16	84	84	CD
cord-018089-m94q75xn	138	17	]	]	-RRB-
cord-018089-m94q75xn	138	18	though	though	IN
cord-018089-m94q75xn	138	19	modeling	modeling	NN
cord-018089-m94q75xn	138	20	methods	method	NNS
cord-018089-m94q75xn	138	21	have	have	VBP
cord-018089-m94q75xn	138	22	yet	yet	RB
cord-018089-m94q75xn	138	23	to	to	TO
cord-018089-m94q75xn	138	24	be	be	VB
cord-018089-m94q75xn	138	25	validated	validate	VBN
cord-018089-m94q75xn	138	26	.	.	.
cord-018089-m94q75xn	138	27	 	 	_SP
cord-018089-m94q75xn	139	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	139	2	A	a	DT
cord-018089-m94q75xn	139	3	virus	virus	NN
cord-018089-m94q75xn	139	4	is	be	VBZ
cord-018089-m94q75xn	139	5	a	a	DT
cord-018089-m94q75xn	139	6	zoonotic	zoonotic	JJ
cord-018089-m94q75xn	139	7	pathogen	pathogen	NN
cord-018089-m94q75xn	139	8	capable	capable	JJ
cord-018089-m94q75xn	139	9	of	of	IN
cord-018089-m94q75xn	139	10	infecting	infect	VBG
cord-018089-m94q75xn	139	11	birds	bird	NNS
cord-018089-m94q75xn	139	12	(	(	-LRB-
cord-018089-m94q75xn	139	13	waterfowl	waterfowl	NNS
cord-018089-m94q75xn	139	14	and	and	CC
cord-018089-m94q75xn	139	15	chickens	chicken	NNS
cord-018089-m94q75xn	139	16	)	)	-RRB-
cord-018089-m94q75xn	139	17	,	,	,
cord-018089-m94q75xn	139	18	swine	swine	NN
cord-018089-m94q75xn	139	19	,	,	,
cord-018089-m94q75xn	139	20	horses	horse	NNS
cord-018089-m94q75xn	139	21	,	,	,
cord-018089-m94q75xn	139	22	felines	feline	NNS
cord-018089-m94q75xn	139	23	,	,	,
cord-018089-m94q75xn	139	24	and	and	CC
cord-018089-m94q75xn	139	25	other	other	JJ
cord-018089-m94q75xn	139	26	species	specie	NNS
cord-018089-m94q75xn	139	27	.	.	.
cord-018089-m94q75xn	140	1	Host	host	NN
cord-018089-m94q75xn	140	2	range	range	NN
cord-018089-m94q75xn	140	3	restriction	restriction	NN
cord-018089-m94q75xn	140	4	of	of	IN
cord-018089-m94q75xn	140	5	different	different	JJ
cord-018089-m94q75xn	140	6	types	type	NNS
cord-018089-m94q75xn	140	7	of	of	IN
cord-018089-m94q75xn	140	8	influenza	influenza	NN
cord-018089-m94q75xn	140	9	viruses	virus	NNS
cord-018089-m94q75xn	140	10	is	be	VBZ
cord-018089-m94q75xn	140	11	observed	observe	VBN
cord-018089-m94q75xn	140	12	.	.	.
cord-018089-m94q75xn	141	1	Species	species	NN
cord-018089-m94q75xn	141	2	-	-	HYPH
cord-018089-m94q75xn	141	3	restricted	restrict	VBN
cord-018089-m94q75xn	141	4	binding	binding	NN
cord-018089-m94q75xn	141	5	of	of	IN
cord-018089-m94q75xn	141	6	viruses	virus	NNS
cord-018089-m94q75xn	141	7	is	be	VBZ
cord-018089-m94q75xn	141	8	mediated	mediate	VBN
cord-018089-m94q75xn	141	9	by	by	IN
cord-018089-m94q75xn	141	10	different	different	JJ
cord-018089-m94q75xn	141	11	types	type	NNS
cord-018089-m94q75xn	141	12	of	of	IN
cord-018089-m94q75xn	141	13	receptor	receptor	NN
cord-018089-m94q75xn	141	14	-	-	HYPH
cord-018089-m94q75xn	141	15	binding	bind	VBG
cord-018089-m94q75xn	141	16	hemaglutinins	hemaglutinin	NNS
cord-018089-m94q75xn	141	17	[	[	-LRB-
cord-018089-m94q75xn	141	18	85	85	CD
cord-018089-m94q75xn	141	19	]	]	-RRB-
cord-018089-m94q75xn	141	20	[	[	-LRB-
cord-018089-m94q75xn	141	21	86	86	CD
cord-018089-m94q75xn	141	22	]	]	-RRB-
cord-018089-m94q75xn	141	23	[	[	-LRB-
cord-018089-m94q75xn	141	24	87	87	CD
cord-018089-m94q75xn	141	25	]	]	-RRB-
cord-018089-m94q75xn	141	26	[	[	-LRB-
cord-018089-m94q75xn	141	27	88	88	CD
cord-018089-m94q75xn	141	28	]	]	-RRB-
cord-018089-m94q75xn	141	29	[	[	-LRB-
cord-018089-m94q75xn	141	30	89	89	CD
cord-018089-m94q75xn	141	31	]	]	-RRB-
cord-018089-m94q75xn	141	32	.	.	.
cord-018089-m94q75xn	142	1	The	the	DT
cord-018089-m94q75xn	142	2	distribution	distribution	NN
cord-018089-m94q75xn	142	3	of	of	IN
cord-018089-m94q75xn	142	4	different	different	JJ
cord-018089-m94q75xn	142	5	types	type	NNS
cord-018089-m94q75xn	142	6	of	of	IN
cord-018089-m94q75xn	142	7	SA	SA	NNP
cord-018089-m94q75xn	142	8	linkages	linkage	NNS
cord-018089-m94q75xn	142	9	has	have	VBZ
cord-018089-m94q75xn	142	10	recently	recently	RB
cord-018089-m94q75xn	142	11	been	be	VBN
cord-018089-m94q75xn	142	12	elucidated	elucidate	VBN
cord-018089-m94q75xn	142	13	in	in	IN
cord-018089-m94q75xn	142	14	humans	human	NNS
cord-018089-m94q75xn	142	15	though	though	IN
cord-018089-m94q75xn	142	16	the	the	DT
cord-018089-m94q75xn	142	17	type	type	NN
cord-018089-m94q75xn	142	18	of	of	IN
cord-018089-m94q75xn	142	19	cell	cell	NN
cord-018089-m94q75xn	142	20	infected	infect	VBN
cord-018089-m94q75xn	142	21	(	(	-LRB-
cord-018089-m94q75xn	142	22	ciliated	ciliated	JJ
cord-018089-m94q75xn	142	23	vs.	vs.	FW
cord-018089-m94q75xn	142	24	nonciliated	nonciliated	JJ
cord-018089-m94q75xn	142	25	)	)	-RRB-
cord-018089-m94q75xn	142	26	is	be	VBZ
cord-018089-m94q75xn	142	27	under	under	IN
cord-018089-m94q75xn	142	28	debate	debate	NN
cord-018089-m94q75xn	142	29	[	[	-LRB-
cord-018089-m94q75xn	142	30	90	90	CD
cord-018089-m94q75xn	142	31	,	,	,
cord-018089-m94q75xn	142	32	91	91	CD
cord-018089-m94q75xn	142	33	]	]	-RRB-
cord-018089-m94q75xn	142	34	.	.	.
cord-018089-m94q75xn	143	1	SA	SA	NNP
cord-018089-m94q75xn	143	2	with	with	IN
cord-018089-m94q75xn	143	3	a2,6Gal	a2,6Gal	VBG
cord-018089-m94q75xn	143	4	linkage	linkage	NN
cord-018089-m94q75xn	143	5	predominates	predominate	VBZ
cord-018089-m94q75xn	143	6	on	on	IN
cord-018089-m94q75xn	143	7	epithelial	epithelial	JJ
cord-018089-m94q75xn	143	8	cells	cell	NNS
cord-018089-m94q75xn	143	9	of	of	IN
cord-018089-m94q75xn	143	10	the	the	DT
cord-018089-m94q75xn	143	11	upper	upper	JJ
cord-018089-m94q75xn	143	12	airway	airway	NN
cord-018089-m94q75xn	143	13	,	,	,
cord-018089-m94q75xn	143	14	including	include	VBG
cord-018089-m94q75xn	143	15	nasal	nasal	NN
cord-018089-m94q75xn	143	16	mucosa	mucosa	NN
cord-018089-m94q75xn	143	17	,	,	,
cord-018089-m94q75xn	143	18	sinuses	sinus	NNS
cord-018089-m94q75xn	143	19	,	,	,
cord-018089-m94q75xn	143	20	bronchi	bronchi	NN
cord-018089-m94q75xn	143	21	,	,	,
cord-018089-m94q75xn	143	22	and	and	CC
cord-018089-m94q75xn	143	23	bronchioles	bronchiole	NNS
cord-018089-m94q75xn	143	24	[	[	-LRB-
cord-018089-m94q75xn	143	25	92	92	CD
cord-018089-m94q75xn	143	26	]	]	-RRB-
cord-018089-m94q75xn	143	27	.	.	.
cord-018089-m94q75xn	144	1	In	in	IN
cord-018089-m94q75xn	144	2	human	human	JJ
cord-018089-m94q75xn	144	3	tracheobronchial	tracheobronchial	JJ
cord-018089-m94q75xn	144	4	epithelial	epithelial	NN
cord-018089-m94q75xn	144	5	(	(	-LRB-
cord-018089-m94q75xn	144	6	HTBE	HTBE	NNP
cord-018089-m94q75xn	144	7	)	)	-RRB-
cord-018089-m94q75xn	144	8	cells	cell	NNS
cord-018089-m94q75xn	144	9	,	,	,
cord-018089-m94q75xn	144	10	oligosaccharides	oligosaccharide	NNS
cord-018089-m94q75xn	144	11	with	with	IN
cord-018089-m94q75xn	144	12	SA	SA	NNP
cord-018089-m94q75xn	144	13	with	with	IN
cord-018089-m94q75xn	144	14	a2,6Gal	a2,6Gal	VBG
cord-018089-m94q75xn	144	15	linkage	linkage	NN
cord-018089-m94q75xn	144	16	predominate	predominate	NNS
cord-018089-m94q75xn	144	17	on	on	IN
cord-018089-m94q75xn	144	18	nonciliated	nonciliated	JJ
cord-018089-m94q75xn	144	19	epithelial	epithelial	JJ
cord-018089-m94q75xn	144	20	cells	cell	NNS
cord-018089-m94q75xn	144	21	[	[	-LRB-
cord-018089-m94q75xn	144	22	91	91	CD
cord-018089-m94q75xn	144	23	]	]	-RRB-
cord-018089-m94q75xn	144	24	although	although	IN
cord-018089-m94q75xn	144	25	these	these	DT
cord-018089-m94q75xn	144	26	oligosaccharides	oligosaccharide	NNS
cord-018089-m94q75xn	144	27	have	have	VBP
cord-018089-m94q75xn	144	28	been	be	VBN
cord-018089-m94q75xn	144	29	described	describe	VBN
cord-018089-m94q75xn	144	30	on	on	IN
cord-018089-m94q75xn	144	31	ciliated	ciliated	JJ
cord-018089-m94q75xn	144	32	and	and	CC
cord-018089-m94q75xn	144	33	goblet	goblet	NN
cord-018089-m94q75xn	144	34	cells	cell	NNS
cord-018089-m94q75xn	144	35	in	in	IN
cord-018089-m94q75xn	144	36	the	the	DT
cord-018089-m94q75xn	144	37	human	human	JJ
cord-018089-m94q75xn	144	38	airway	airway	NN
cord-018089-m94q75xn	144	39	[	[	-LRB-
cord-018089-m94q75xn	144	40	93	93	CD
cord-018089-m94q75xn	144	41	]	]	-RRB-
cord-018089-m94q75xn	144	42	.	.	.
cord-018089-m94q75xn	145	1	Lower	low	JJR
cord-018089-m94q75xn	145	2	airways	airway	NNS
cord-018089-m94q75xn	145	3	contain	contain	VBP
cord-018089-m94q75xn	145	4	SA	SA	NNP
cord-018089-m94q75xn	145	5	with	with	IN
cord-018089-m94q75xn	145	6	mostly	mostly	RB
cord-018089-m94q75xn	145	7	a2,3Gal	a2,3gal	CD
cord-018089-m94q75xn	145	8	linkage	linkage	NN
cord-018089-m94q75xn	145	9	,	,	,
cord-018089-m94q75xn	145	10	in	in	IN
cord-018089-m94q75xn	145	11	addition	addition	NN
cord-018089-m94q75xn	145	12	to	to	IN
cord-018089-m94q75xn	145	13	SA	SA	NNP
cord-018089-m94q75xn	145	14	with	with	IN
cord-018089-m94q75xn	145	15	a2,6Gal	a2,6Gal	VBG
cord-018089-m94q75xn	145	16	linkage	linkage	NN
cord-018089-m94q75xn	145	17	[	[	-LRB-
cord-018089-m94q75xn	145	18	92	92	CD
cord-018089-m94q75xn	145	19	,	,	,
cord-018089-m94q75xn	145	20	94	94	CD
cord-018089-m94q75xn	145	21	]	]	-RRB-
cord-018089-m94q75xn	145	22	.	.	.
cord-018089-m94q75xn	146	1	Host	host	NN
cord-018089-m94q75xn	146	2	restriction	restriction	NN
cord-018089-m94q75xn	146	3	is	be	VBZ
cord-018089-m94q75xn	146	4	not	not	RB
cord-018089-m94q75xn	146	5	absolute	absolute	JJ
cord-018089-m94q75xn	146	6	,	,	,
cord-018089-m94q75xn	146	7	and	and	CC
cord-018089-m94q75xn	146	8	human	human	JJ
cord-018089-m94q75xn	146	9	infections	infection	NNS
cord-018089-m94q75xn	146	10	with	with	IN
cord-018089-m94q75xn	146	11	avian	avian	JJ
cord-018089-m94q75xn	146	12	influenza	influenza	NN
cord-018089-m94q75xn	146	13	viruses	virus	NNS
cord-018089-m94q75xn	146	14	(	(	-LRB-
cord-018089-m94q75xn	146	15	including	include	VBG
cord-018089-m94q75xn	146	16	H5N1	H5N1	NNP
cord-018089-m94q75xn	146	17	,	,	,
cord-018089-m94q75xn	146	18	H9N2	H9N2	NNP
cord-018089-m94q75xn	146	19	,	,	,
cord-018089-m94q75xn	146	20	and	and	CC
cord-018089-m94q75xn	146	21	H7N7	H7N7	NNP
cord-018089-m94q75xn	146	22	viruses	virus	NNS
cord-018089-m94q75xn	146	23	)	)	-RRB-
cord-018089-m94q75xn	146	24	have	have	VBP
cord-018089-m94q75xn	146	25	been	be	VBN
cord-018089-m94q75xn	146	26	extensively	extensively	RB
cord-018089-m94q75xn	146	27	described	describe	VBN
cord-018089-m94q75xn	146	28	[	[	-LRB-
cord-018089-m94q75xn	146	29	95	95	CD
cord-018089-m94q75xn	146	30	]	]	-RRB-
cord-018089-m94q75xn	146	31	[	[	-LRB-
cord-018089-m94q75xn	146	32	96	96	CD
cord-018089-m94q75xn	146	33	]	]	-RRB-
cord-018089-m94q75xn	146	34	[	[	-LRB-
cord-018089-m94q75xn	146	35	97	97	CD
cord-018089-m94q75xn	146	36	]	]	-RRB-
cord-018089-m94q75xn	146	37	[	[	-LRB-
cord-018089-m94q75xn	146	38	98	98	CD
cord-018089-m94q75xn	146	39	]	]	-RRB-
cord-018089-m94q75xn	146	40	[	[	-LRB-
cord-018089-m94q75xn	146	41	99	99	CD
cord-018089-m94q75xn	146	42	]	]	-RRB-
cord-018089-m94q75xn	146	43	[	[	-LRB-
cord-018089-m94q75xn	146	44	100	100	CD
cord-018089-m94q75xn	146	45	]	]	-RRB-
cord-018089-m94q75xn	146	46	.	.	.
cord-018089-m94q75xn	147	1	H5N1	H5N1	NNP
cord-018089-m94q75xn	147	2	binds	bind	VBZ
cord-018089-m94q75xn	147	3	type	type	NN
cord-018089-m94q75xn	147	4	II	II	NNP
cord-018089-m94q75xn	147	5	pneumocytes	pneumocyte	NNS
cord-018089-m94q75xn	147	6	and	and	CC
cord-018089-m94q75xn	147	7	macrophages	macrophage	NNS
cord-018089-m94q75xn	147	8	of	of	IN
cord-018089-m94q75xn	147	9	the	the	DT
cord-018089-m94q75xn	147	10	lower	low	JJR
cord-018089-m94q75xn	147	11	respiratory	respiratory	JJ
cord-018089-m94q75xn	147	12	tract	tract	NN
cord-018089-m94q75xn	147	13	in	in	IN
cord-018089-m94q75xn	147	14	humans	human	NNS
cord-018089-m94q75xn	147	15	[	[	-LRB-
cord-018089-m94q75xn	147	16	92	92	CD
cord-018089-m94q75xn	147	17	,	,	,
cord-018089-m94q75xn	147	18	94	94	CD
cord-018089-m94q75xn	147	19	,	,	,
cord-018089-m94q75xn	147	20	101	101	CD
cord-018089-m94q75xn	147	21	]	]	-RRB-
cord-018089-m94q75xn	147	22	.	.	.
cord-018089-m94q75xn	148	1	H5N1	H5N1	NNP
cord-018089-m94q75xn	148	2	infection	infection	NN
cord-018089-m94q75xn	148	3	of	of	IN
cord-018089-m94q75xn	148	4	ciliated	ciliated	JJ
cord-018089-m94q75xn	148	5	cells	cell	NNS
cord-018089-m94q75xn	148	6	in	in	IN
cord-018089-m94q75xn	148	7	HTBE	HTBE	NNP
cord-018089-m94q75xn	148	8	cell	cell	NN
cord-018089-m94q75xn	148	9	culture	culture	NN
cord-018089-m94q75xn	148	10	with	with	IN
cord-018089-m94q75xn	148	11	limited	limited	JJ
cord-018089-m94q75xn	148	12	cell	cell	NN
cord-018089-m94q75xn	148	13	-	-	HYPH
cord-018089-m94q75xn	148	14	to	to	IN
cord-018089-m94q75xn	148	15	-	-	HYPH
cord-018089-m94q75xn	148	16	cell	cell	NN
cord-018089-m94q75xn	148	17	spread	spread	NN
cord-018089-m94q75xn	148	18	[	[	-LRB-
cord-018089-m94q75xn	148	19	90	90	CD
cord-018089-m94q75xn	148	20	]	]	-RRB-
cord-018089-m94q75xn	148	21	and	and	CC
cord-018089-m94q75xn	148	22	of	of	IN
cord-018089-m94q75xn	148	23	human	human	JJ
cord-018089-m94q75xn	148	24	nasopharyngeal	nasopharyngeal	NN
cord-018089-m94q75xn	148	25	,	,	,
cord-018089-m94q75xn	148	26	adenoid	adenoid	NN
cord-018089-m94q75xn	148	27	,	,	,
cord-018089-m94q75xn	148	28	and	and	CC
cord-018089-m94q75xn	148	29	tonsillar	tonsillar	JJ
cord-018089-m94q75xn	148	30	ex	ex	NN
cord-018089-m94q75xn	148	31	vivo	vivo	NN
cord-018089-m94q75xn	148	32	cell	cell	NN
cord-018089-m94q75xn	148	33	cultures	culture	NNS
cord-018089-m94q75xn	148	34	has	have	VBZ
cord-018089-m94q75xn	148	35	been	be	VBN
cord-018089-m94q75xn	148	36	shown	show	VBN
cord-018089-m94q75xn	148	37	[	[	-LRB-
cord-018089-m94q75xn	148	38	102	102	CD
cord-018089-m94q75xn	148	39	]	]	-RRB-
cord-018089-m94q75xn	148	40	.	.	.
cord-018089-m94q75xn	149	1	Binding	bind	VBG
cord-018089-m94q75xn	149	2	of	of	IN
cord-018089-m94q75xn	149	3	H5N1	H5N1	NNP
cord-018089-m94q75xn	149	4	viruses	virus	NNS
cord-018089-m94q75xn	149	5	to	to	IN
cord-018089-m94q75xn	149	6	saccharides	saccharide	NNS
cord-018089-m94q75xn	149	7	terminating	terminate	VBG
cord-018089-m94q75xn	149	8	in	in	IN
cord-018089-m94q75xn	149	9	a2,6Gal	a2,6Gal	VBG
cord-018089-m94q75xn	149	10	SA	SA	NNP
cord-018089-m94q75xn	149	11	linkage	linkage	NN
cord-018089-m94q75xn	149	12	has	have	VBZ
cord-018089-m94q75xn	149	13	been	be	VBN
cord-018089-m94q75xn	149	14	achieved	achieve	VBN
cord-018089-m94q75xn	149	15	by	by	IN
cord-018089-m94q75xn	149	16	mutating	mutate	VBG
cord-018089-m94q75xn	149	17	HA	HA	NNP
cord-018089-m94q75xn	149	18	amino	amino	NN
cord-018089-m94q75xn	149	19	acid	acid	NN
cord-018089-m94q75xn	149	20	residues	residue	NNS
cord-018089-m94q75xn	149	21	at	at	IN
cord-018089-m94q75xn	149	22	positions	position	NNS
cord-018089-m94q75xn	149	23	182	182	CD
cord-018089-m94q75xn	149	24	and	and	CC
cord-018089-m94q75xn	149	25	192	192	CD
cord-018089-m94q75xn	149	26	,	,	,
cord-018089-m94q75xn	149	27	suggesting	suggest	VBG
cord-018089-m94q75xn	149	28	potential	potential	NN
cord-018089-m94q75xn	149	29	for	for	IN
cord-018089-m94q75xn	149	30	adaptation	adaptation	NN
cord-018089-m94q75xn	149	31	to	to	IN
cord-018089-m94q75xn	149	32	the	the	DT
cord-018089-m94q75xn	149	33	human	human	JJ
cord-018089-m94q75xn	149	34	host	host	NN
cord-018089-m94q75xn	149	35	[	[	-LRB-
cord-018089-m94q75xn	149	36	103	103	CD
cord-018089-m94q75xn	149	37	]	]	-RRB-
cord-018089-m94q75xn	149	38	.	.	.
cord-018089-m94q75xn	150	1	Differences	difference	NNS
cord-018089-m94q75xn	150	2	in	in	IN
cord-018089-m94q75xn	150	3	influenza	influenza	NN
cord-018089-m94q75xn	150	4	virus	virus	NN
cord-018089-m94q75xn	150	5	receptors	receptor	NNS
cord-018089-m94q75xn	150	6	among	among	IN
cord-018089-m94q75xn	150	7	avian	avian	JJ
cord-018089-m94q75xn	150	8	species	specie	NNS
cord-018089-m94q75xn	150	9	have	have	VBP
cord-018089-m94q75xn	150	10	been	be	VBN
cord-018089-m94q75xn	150	11	described	describe	VBN
cord-018089-m94q75xn	150	12	and	and	CC
cord-018089-m94q75xn	150	13	are	be	VBP
cord-018089-m94q75xn	150	14	reflected	reflect	VBN
cord-018089-m94q75xn	150	15	in	in	IN
cord-018089-m94q75xn	150	16	differential	differential	JJ
cord-018089-m94q75xn	150	17	binding	binding	NN
cord-018089-m94q75xn	150	18	of	of	IN
cord-018089-m94q75xn	150	19	different	different	JJ
cord-018089-m94q75xn	150	20	types	type	NNS
cord-018089-m94q75xn	150	21	of	of	IN
cord-018089-m94q75xn	150	22	avian	avian	JJ
cord-018089-m94q75xn	150	23	influenza	influenza	NN
cord-018089-m94q75xn	150	24	viruses	virus	NNS
cord-018089-m94q75xn	150	25	.	.	.
cord-018089-m94q75xn	151	1	Although	although	IN
cord-018089-m94q75xn	151	2	chicken	chicken	NN
cord-018089-m94q75xn	151	3	and	and	CC
cord-018089-m94q75xn	151	4	duck	duck	NN
cord-018089-m94q75xn	151	5	influenza	influenza	NN
cord-018089-m94q75xn	151	6	viruses	virus	NNS
cord-018089-m94q75xn	151	7	preferentially	preferentially	RB
cord-018089-m94q75xn	151	8	bind	bind	VBP
cord-018089-m94q75xn	151	9	a2,3Gal	a2,3gal	NN
cord-018089-m94q75xn	151	10	-	-	HYPH
cord-018089-m94q75xn	151	11	linked	link	VBN
cord-018089-m94q75xn	151	12	SA	SA	NNP
cord-018089-m94q75xn	151	13	,	,	,
cord-018089-m94q75xn	151	14	viruses	virus	NNS
cord-018089-m94q75xn	151	15	from	from	IN
cord-018089-m94q75xn	151	16	chickens	chicken	NNS
cord-018089-m94q75xn	151	17	had	have	VBD
cord-018089-m94q75xn	151	18	greater	great	JJR
cord-018089-m94q75xn	151	19	affinity	affinity	NN
cord-018089-m94q75xn	151	20	for	for	IN
cord-018089-m94q75xn	151	21	SA	SA	NNP
cord-018089-m94q75xn	151	22	where	where	WRB
cord-018089-m94q75xn	151	23	the	the	DT
cord-018089-m94q75xn	151	24	third	third	JJ
cord-018089-m94q75xn	151	25	sugar	sugar	NN
cord-018089-m94q75xn	151	26	moiety	moiety	NN
cord-018089-m94q75xn	151	27	was	be	VBD
cord-018089-m94q75xn	151	28	a	a	DT
cord-018089-m94q75xn	151	29	b(1	b(1	CD
cord-018089-m94q75xn	151	30	-	-	HYPH
cord-018089-m94q75xn	151	31	4)GlcNAc	4)glcnac	NN
cord-018089-m94q75xn	151	32	-	-	HYPH
cord-018089-m94q75xn	151	33	containing	contain	VBG
cord-018089-m94q75xn	151	34	synthetic	synthetic	JJ
cord-018089-m94q75xn	151	35	sialylglycopolymer	sialylglycopolymer	NN
cord-018089-m94q75xn	151	36	.	.	.
cord-018089-m94q75xn	152	1	Duck	duck	NN
cord-018089-m94q75xn	152	2	viruses	virus	NNS
cord-018089-m94q75xn	152	3	preferred	prefer	VBD
cord-018089-m94q75xn	152	4	b(1	b(1	NNP
cord-018089-m94q75xn	152	5	-	-	HYPH
cord-018089-m94q75xn	152	6	3)GalNAc	3)galnac	NN
cord-018089-m94q75xn	152	7	sugar	sugar	NN
cord-018089-m94q75xn	152	8	moieties	moiety	NNS
cord-018089-m94q75xn	152	9	in	in	IN
cord-018089-m94q75xn	152	10	the	the	DT
cord-018089-m94q75xn	152	11	third	third	JJ
cord-018089-m94q75xn	152	12	position	position	NN
cord-018089-m94q75xn	152	13	[	[	-LRB-
cord-018089-m94q75xn	152	14	104	104	CD
cord-018089-m94q75xn	152	15	]	]	-RRB-
cord-018089-m94q75xn	152	16	.	.	.
cord-018089-m94q75xn	153	1	Distribution	distribution	NN
cord-018089-m94q75xn	153	2	of	of	IN
cord-018089-m94q75xn	153	3	influenza	influenza	NN
cord-018089-m94q75xn	153	4	virus	virus	NN
cord-018089-m94q75xn	153	5	receptors	receptor	NNS
cord-018089-m94q75xn	153	6	reflects	reflect	VBZ
cord-018089-m94q75xn	153	7	the	the	DT
cord-018089-m94q75xn	153	8	sites	site	NNS
cord-018089-m94q75xn	153	9	of	of	IN
cord-018089-m94q75xn	153	10	replication	replication	NN
cord-018089-m94q75xn	153	11	.	.	.
cord-018089-m94q75xn	154	1	In	in	IN
cord-018089-m94q75xn	154	2	chickens	chicken	NNS
cord-018089-m94q75xn	154	3	and	and	CC
cord-018089-m94q75xn	154	4	waterfowl	waterfowl	NNS
cord-018089-m94q75xn	154	5	,	,	,
cord-018089-m94q75xn	154	6	SA	SA	NNP
cord-018089-m94q75xn	154	7	with	with	IN
cord-018089-m94q75xn	154	8	a2,3Gal	a2,3gal	CD
cord-018089-m94q75xn	154	9	linkage	linkage	NN
cord-018089-m94q75xn	154	10	is	be	VBZ
cord-018089-m94q75xn	154	11	found	find	VBN
cord-018089-m94q75xn	154	12	in	in	IN
cord-018089-m94q75xn	154	13	the	the	DT
cord-018089-m94q75xn	154	14	upper	upper	JJ
cord-018089-m94q75xn	154	15	respiratory	respiratory	JJ
cord-018089-m94q75xn	154	16	tract	tract	NN
cord-018089-m94q75xn	154	17	and	and	CC
cord-018089-m94q75xn	154	18	intestines	intestine	NNS
cord-018089-m94q75xn	154	19	.	.	.
cord-018089-m94q75xn	155	1	Some	some	DT
cord-018089-m94q75xn	155	2	species	specie	NNS
cord-018089-m94q75xn	155	3	demonstrate	demonstrate	VBP
cord-018089-m94q75xn	155	4	the	the	DT
cord-018089-m94q75xn	155	5	ability	ability	NN
cord-018089-m94q75xn	155	6	to	to	TO
cord-018089-m94q75xn	155	7	support	support	VB
cord-018089-m94q75xn	155	8	replication	replication	NN
cord-018089-m94q75xn	155	9	of	of	IN
cord-018089-m94q75xn	155	10	both	both	DT
cord-018089-m94q75xn	155	11	human	human	JJ
cord-018089-m94q75xn	155	12	and	and	CC
cord-018089-m94q75xn	155	13	avian	avian	JJ
cord-018089-m94q75xn	155	14	influenza	influenza	NN
cord-018089-m94q75xn	155	15	viruses	virus	NNS
cord-018089-m94q75xn	155	16	.	.	.
cord-018089-m94q75xn	156	1	The	the	DT
cord-018089-m94q75xn	156	2	respiratory	respiratory	JJ
cord-018089-m94q75xn	156	3	tract	tract	NN
cord-018089-m94q75xn	156	4	and	and	CC
cord-018089-m94q75xn	156	5	intestines	intestine	NNS
cord-018089-m94q75xn	156	6	of	of	IN
cord-018089-m94q75xn	156	7	quail	quail	NNS
cord-018089-m94q75xn	156	8	contain	contain	VBP
cord-018089-m94q75xn	156	9	both	both	DT
cord-018089-m94q75xn	156	10	a2,3Galand	a2,3galand	DT
cord-018089-m94q75xn	156	11	a2,6Gal	a2,6gal	RB
cord-018089-m94q75xn	156	12	-	-	HYPH
cord-018089-m94q75xn	156	13	linked	link	VBN
cord-018089-m94q75xn	156	14	terminal	terminal	JJ
cord-018089-m94q75xn	156	15	sialic	sialic	JJ
cord-018089-m94q75xn	156	16	acids	acid	NNS
cord-018089-m94q75xn	156	17	[	[	-LRB-
cord-018089-m94q75xn	156	18	105	105	CD
cord-018089-m94q75xn	156	19	]	]	-RRB-
cord-018089-m94q75xn	156	20	.	.	.
cord-018089-m94q75xn	157	1	In	in	IN
cord-018089-m94q75xn	157	2	swine	swine	NN
cord-018089-m94q75xn	157	3	,	,	,
cord-018089-m94q75xn	157	4	oligosaccharides	oligosaccharide	NNS
cord-018089-m94q75xn	157	5	with	with	IN
cord-018089-m94q75xn	157	6	both	both	DT
cord-018089-m94q75xn	157	7	types	type	NNS
cord-018089-m94q75xn	157	8	of	of	IN
cord-018089-m94q75xn	157	9	linkages	linkage	NNS
cord-018089-m94q75xn	157	10	may	may	MD
cord-018089-m94q75xn	157	11	be	be	VB
cord-018089-m94q75xn	157	12	found	find	VBN
cord-018089-m94q75xn	157	13	and	and	CC
cord-018089-m94q75xn	157	14	suggest	suggest	VB
cord-018089-m94q75xn	157	15	this	this	DT
cord-018089-m94q75xn	157	16	species	species	NN
cord-018089-m94q75xn	157	17	serves	serve	VBZ
cord-018089-m94q75xn	157	18	as	as	IN
cord-018089-m94q75xn	157	19	a	a	DT
cord-018089-m94q75xn	157	20	mixing	mix	VBG
cord-018089-m94q75xn	157	21	vessel	vessel	NN
cord-018089-m94q75xn	157	22	where	where	WRB
cord-018089-m94q75xn	157	23	human	human	JJ
cord-018089-m94q75xn	157	24	,	,	,
cord-018089-m94q75xn	157	25	avian	avian	JJ
cord-018089-m94q75xn	157	26	,	,	,
cord-018089-m94q75xn	157	27	and	and	CC
cord-018089-m94q75xn	157	28	swine	swine	NN
cord-018089-m94q75xn	157	29	influenza	influenza	NN
cord-018089-m94q75xn	157	30	viruses	virus	NNS
cord-018089-m94q75xn	157	31	can	can	MD
cord-018089-m94q75xn	157	32	reassort	reassort	VB
cord-018089-m94q75xn	157	33	[	[	-LRB-
cord-018089-m94q75xn	157	34	106	106	CD
cord-018089-m94q75xn	157	35	,	,	,
cord-018089-m94q75xn	157	36	107	107	CD
cord-018089-m94q75xn	157	37	]	]	-RRB-
cord-018089-m94q75xn	157	38	.	.	.
cord-018089-m94q75xn	158	1	Uncomplicated	uncomplicated	JJ
cord-018089-m94q75xn	158	2	influenza	influenza	NN
cord-018089-m94q75xn	158	3	in	in	IN
cord-018089-m94q75xn	158	4	humans	human	NNS
cord-018089-m94q75xn	158	5	is	be	VBZ
cord-018089-m94q75xn	158	6	an	an	DT
cord-018089-m94q75xn	158	7	upper	upper	JJ
cord-018089-m94q75xn	158	8	respiratory	respiratory	JJ
cord-018089-m94q75xn	158	9	tract	tract	NN
cord-018089-m94q75xn	158	10	infection	infection	NN
cord-018089-m94q75xn	158	11	characterized	characterize	VBN
cord-018089-m94q75xn	158	12	by	by	IN
cord-018089-m94q75xn	158	13	cough	cough	NN
cord-018089-m94q75xn	158	14	,	,	,
cord-018089-m94q75xn	158	15	headache	headache	NN
cord-018089-m94q75xn	158	16	,	,	,
cord-018089-m94q75xn	158	17	malaise	malaise	NN
cord-018089-m94q75xn	158	18	,	,	,
cord-018089-m94q75xn	158	19	and	and	CC
cord-018089-m94q75xn	158	20	fever	fever	NN
cord-018089-m94q75xn	158	21	(	(	-LRB-
cord-018089-m94q75xn	158	22	influenza	influenza	NN
cord-018089-m94q75xn	158	23	-	-	HYPH
cord-018089-m94q75xn	158	24	like	like	JJ
cord-018089-m94q75xn	158	25	illness	illness	NN
cord-018089-m94q75xn	158	26	)	)	-RRB-
cord-018089-m94q75xn	158	27	.	.	.
cord-018089-m94q75xn	159	1	These	these	DT
cord-018089-m94q75xn	159	2	symptoms	symptom	NNS
cord-018089-m94q75xn	159	3	are	be	VBP
cord-018089-m94q75xn	159	4	nonspecific	nonspecific	JJ
cord-018089-m94q75xn	159	5	and	and	CC
cord-018089-m94q75xn	159	6	are	be	VBP
cord-018089-m94q75xn	159	7	not	not	RB
cord-018089-m94q75xn	159	8	predictive	predictive	JJ
cord-018089-m94q75xn	159	9	of	of	IN
cord-018089-m94q75xn	159	10	influenza	influenza	NN
cord-018089-m94q75xn	159	11	virus	virus	NN
cord-018089-m94q75xn	159	12	infection	infection	NN
cord-018089-m94q75xn	159	13	,	,	,
cord-018089-m94q75xn	159	14	particularly	particularly	RB
cord-018089-m94q75xn	159	15	in	in	IN
cord-018089-m94q75xn	159	16	individuals	individual	NNS
cord-018089-m94q75xn	159	17	<	<	XX
cord-018089-m94q75xn	159	18	60	60	CD
cord-018089-m94q75xn	159	19	years	year	NNS
cord-018089-m94q75xn	159	20	old	old	JJ
cord-018089-m94q75xn	159	21	[	[	-LRB-
cord-018089-m94q75xn	159	22	108	108	CD
cord-018089-m94q75xn	159	23	]	]	-RRB-
cord-018089-m94q75xn	159	24	.	.	.
cord-018089-m94q75xn	160	1	Pulmonary	pulmonary	JJ
cord-018089-m94q75xn	160	2	and	and	CC
cord-018089-m94q75xn	160	3	extrapulmonary	extrapulmonary	JJ
cord-018089-m94q75xn	160	4	complications	complication	NNS
cord-018089-m94q75xn	160	5	may	may	MD
cord-018089-m94q75xn	160	6	arise	arise	VB
cord-018089-m94q75xn	160	7	.	.	.
cord-018089-m94q75xn	161	1	The	the	DT
cord-018089-m94q75xn	161	2	latter	latter	JJ
cord-018089-m94q75xn	161	3	consist	consist	NN
cord-018089-m94q75xn	161	4	of	of	IN
cord-018089-m94q75xn	161	5	central	central	JJ
cord-018089-m94q75xn	161	6	nervous	nervous	JJ
cord-018089-m94q75xn	161	7	system	system	NN
cord-018089-m94q75xn	161	8	involvement	involvement	NN
cord-018089-m94q75xn	161	9	(	(	-LRB-
cord-018089-m94q75xn	161	10	encephalitis	encephalitis	RB
cord-018089-m94q75xn	161	11	,	,	,
cord-018089-m94q75xn	161	12	acute	acute	JJ
cord-018089-m94q75xn	161	13	necrotizing	necrotize	VBG
cord-018089-m94q75xn	161	14	encephalopathy	encephalopathy	NN
cord-018089-m94q75xn	161	15	,	,	,
cord-018089-m94q75xn	161	16	Reye	Reye	NNP
cord-018089-m94q75xn	161	17	's	's	POS
cord-018089-m94q75xn	161	18	syndrome	syndrome	NN
cord-018089-m94q75xn	161	19	,	,	,
cord-018089-m94q75xn	161	20	and	and	CC
cord-018089-m94q75xn	161	21	myelitis	myelitis	NNP
cord-018089-m94q75xn	161	22	)	)	-RRB-
cord-018089-m94q75xn	162	1	[	[	-LRB-
cord-018089-m94q75xn	162	2	14	14	CD
cord-018089-m94q75xn	162	3	]	]	-RRB-
cord-018089-m94q75xn	162	4	,	,	,
cord-018089-m94q75xn	162	5	myositis	myositis	NN
cord-018089-m94q75xn	162	6	/	/	SYM
cord-018089-m94q75xn	162	7	rhabdomyositis	rhabdomyositis	NNP
cord-018089-m94q75xn	162	8	[	[	-LRB-
cord-018089-m94q75xn	162	9	109	109	CD
cord-018089-m94q75xn	162	10	]	]	-RRB-
cord-018089-m94q75xn	162	11	,	,	,
cord-018089-m94q75xn	162	12	myocarditis	myocarditis	NN
cord-018089-m94q75xn	162	13	[	[	-LRB-
cord-018089-m94q75xn	162	14	109	109	CD
cord-018089-m94q75xn	162	15	,	,	,
cord-018089-m94q75xn	162	16	110	110	CD
cord-018089-m94q75xn	162	17	]	]	-RRB-
cord-018089-m94q75xn	162	18	,	,	,
cord-018089-m94q75xn	162	19	increased	increase	VBN
cord-018089-m94q75xn	162	20	cardiovascular	cardiovascular	JJ
cord-018089-m94q75xn	162	21	events	event	NNS
cord-018089-m94q75xn	162	22	[	[	-LRB-
cord-018089-m94q75xn	162	23	111	111	CD
cord-018089-m94q75xn	162	24	]	]	-RRB-
cord-018089-m94q75xn	162	25	,	,	,
cord-018089-m94q75xn	162	26	disseminated	disseminate	VBN
cord-018089-m94q75xn	162	27	intravascular	intravascular	JJ
cord-018089-m94q75xn	162	28	coagulation	coagulation	NN
cord-018089-m94q75xn	162	29	[	[	-LRB-
cord-018089-m94q75xn	162	30	109	109	CD
cord-018089-m94q75xn	162	31	]	]	-RRB-
cord-018089-m94q75xn	162	32	,	,	,
cord-018089-m94q75xn	162	33	and	and	CC
cord-018089-m94q75xn	162	34	toxic	toxic	JJ
cord-018089-m94q75xn	162	35	and	and	CC
cord-018089-m94q75xn	162	36	septic	septic	JJ
cord-018089-m94q75xn	162	37	shock	shock	NN
cord-018089-m94q75xn	162	38	(	(	-LRB-
cord-018089-m94q75xn	162	39	bacterial	bacterial	JJ
cord-018089-m94q75xn	162	40	and	and	CC
cord-018089-m94q75xn	162	41	nonbacterial	nonbacterial	NN
cord-018089-m94q75xn	162	42	)	)	-RRB-
cord-018089-m94q75xn	162	43	[	[	-LRB-
cord-018089-m94q75xn	162	44	15	15	CD
cord-018089-m94q75xn	162	45	,	,	,
cord-018089-m94q75xn	162	46	18	18	CD
cord-018089-m94q75xn	162	47	,	,	,
cord-018089-m94q75xn	162	48	109	109	CD
cord-018089-m94q75xn	162	49	]	]	-RRB-
cord-018089-m94q75xn	162	50	.	.	.
cord-018089-m94q75xn	163	1	Pulmonary	pulmonary	JJ
cord-018089-m94q75xn	163	2	complications	complication	NNS
cord-018089-m94q75xn	163	3	include	include	VBP
cord-018089-m94q75xn	163	4	primary	primary	JJ
cord-018089-m94q75xn	163	5	viral	viral	JJ
cord-018089-m94q75xn	163	6	pneumonia	pneumonia	NN
cord-018089-m94q75xn	163	7	,	,	,
cord-018089-m94q75xn	163	8	secondary	secondary	JJ
cord-018089-m94q75xn	163	9	bacterial	bacterial	JJ
cord-018089-m94q75xn	163	10	pneumonia	pneumonia	NN
cord-018089-m94q75xn	163	11	(	(	-LRB-
cord-018089-m94q75xn	163	12	see	see	VB
cord-018089-m94q75xn	163	13	below	below	RB
cord-018089-m94q75xn	163	14	)	)	-RRB-
cord-018089-m94q75xn	163	15	,	,	,
cord-018089-m94q75xn	163	16	and	and	CC
cord-018089-m94q75xn	163	17	exacerbation	exacerbation	NN
cord-018089-m94q75xn	163	18	of	of	IN
cord-018089-m94q75xn	163	19	chronic	chronic	JJ
cord-018089-m94q75xn	163	20	lung	lung	NN
cord-018089-m94q75xn	163	21	disease	disease	NN
cord-018089-m94q75xn	163	22	[	[	-LRB-
cord-018089-m94q75xn	163	23	109	109	CD
cord-018089-m94q75xn	163	24	,	,	,
cord-018089-m94q75xn	163	25	112	112	CD
cord-018089-m94q75xn	163	26	]	]	-RRB-
cord-018089-m94q75xn	163	27	.	.	.
cord-018089-m94q75xn	164	1	Acute	acute	JJ
cord-018089-m94q75xn	164	2	lung	lung	NN
cord-018089-m94q75xn	164	3	injury	injury	NN
cord-018089-m94q75xn	164	4	(	(	-LRB-
cord-018089-m94q75xn	165	1	ALI)/acute	ali)/acute	JJ
cord-018089-m94q75xn	165	2	respiratory	respiratory	JJ
cord-018089-m94q75xn	165	3	distress	distress	NN
cord-018089-m94q75xn	165	4	syndrome	syndrome	NN
cord-018089-m94q75xn	165	5	(	(	-LRB-
cord-018089-m94q75xn	165	6	ARDS	ARDS	NNP
cord-018089-m94q75xn	165	7	)	)	-RRB-
cord-018089-m94q75xn	165	8	,	,	,
cord-018089-m94q75xn	165	9	multiorgan	multiorgan	NNP
cord-018089-m94q75xn	165	10	failure	failure	NN
cord-018089-m94q75xn	165	11	,	,	,
cord-018089-m94q75xn	165	12	profound	profound	JJ
cord-018089-m94q75xn	165	13	lymphopenia	lymphopenia	NNP
cord-018089-m94q75xn	165	14	,	,	,
cord-018089-m94q75xn	165	15	and	and	CC
cord-018089-m94q75xn	165	16	hemophagocytosis	hemophagocytosis	NN
cord-018089-m94q75xn	165	17	have	have	VBP
cord-018089-m94q75xn	165	18	been	be	VBN
cord-018089-m94q75xn	165	19	associated	associate	VBN
cord-018089-m94q75xn	165	20	with	with	IN
cord-018089-m94q75xn	165	21	H5N1	H5N1	NNP
cord-018089-m94q75xn	165	22	infection	infection	NN
cord-018089-m94q75xn	165	23	and	and	CC
cord-018089-m94q75xn	165	24	carry	carry	VB
cord-018089-m94q75xn	165	25	high	high	JJ
cord-018089-m94q75xn	165	26	mortality	mortality	NN
cord-018089-m94q75xn	165	27	rates	rate	NNS
cord-018089-m94q75xn	165	28	[	[	-LRB-
cord-018089-m94q75xn	165	29	15	15	CD
cord-018089-m94q75xn	165	30	,	,	,
cord-018089-m94q75xn	165	31	95	95	CD
cord-018089-m94q75xn	165	32	,	,	,
cord-018089-m94q75xn	165	33	[	[	-LRB-
cord-018089-m94q75xn	165	34	113	113	CD
cord-018089-m94q75xn	165	35	]	]	-RRB-
cord-018089-m94q75xn	165	36	[	[	-LRB-
cord-018089-m94q75xn	165	37	114	114	CD
cord-018089-m94q75xn	165	38	]	]	-RRB-
cord-018089-m94q75xn	165	39	[	[	-LRB-
cord-018089-m94q75xn	165	40	115	115	CD
cord-018089-m94q75xn	165	41	]	]	-RRB-
cord-018089-m94q75xn	165	42	.	.	.
cord-018089-m94q75xn	166	1	Bacterial	bacterial	JJ
cord-018089-m94q75xn	166	2	pneumonia	pneumonia	NN
cord-018089-m94q75xn	166	3	following	follow	VBG
cord-018089-m94q75xn	166	4	influenza	influenza	NN
cord-018089-m94q75xn	166	5	virus	virus	NN
cord-018089-m94q75xn	166	6	infection	infection	NN
cord-018089-m94q75xn	166	7	is	be	VBZ
cord-018089-m94q75xn	166	8	a	a	DT
cord-018089-m94q75xn	166	9	well	well	RB
cord-018089-m94q75xn	166	10	-	-	HYPH
cord-018089-m94q75xn	166	11	recognized	recognize	VBN
cord-018089-m94q75xn	166	12	complication	complication	NN
cord-018089-m94q75xn	166	13	of	of	IN
cord-018089-m94q75xn	166	14	influenza	influenza	NN
cord-018089-m94q75xn	166	15	since	since	IN
cord-018089-m94q75xn	166	16	the	the	DT
cord-018089-m94q75xn	166	17	pandemic	pandemic	NN
cord-018089-m94q75xn	166	18	of	of	IN
cord-018089-m94q75xn	166	19	1918	1918	CD
cord-018089-m94q75xn	166	20	[	[	-LRB-
cord-018089-m94q75xn	166	21	116	116	CD
cord-018089-m94q75xn	166	22	]	]	-RRB-
cord-018089-m94q75xn	166	23	.	.	.
cord-018089-m94q75xn	167	1	More	more	RBR
cord-018089-m94q75xn	167	2	recently	recently	RB
cord-018089-m94q75xn	167	3	,	,	,
cord-018089-m94q75xn	167	4	pediatric	pediatric	JJ
cord-018089-m94q75xn	167	5	deaths	death	NNS
cord-018089-m94q75xn	167	6	have	have	VBP
cord-018089-m94q75xn	167	7	been	be	VBN
cord-018089-m94q75xn	167	8	attributed	attribute	VBN
cord-018089-m94q75xn	167	9	to	to	IN
cord-018089-m94q75xn	167	10	copathogenesis	copathogenesis	NN
cord-018089-m94q75xn	167	11	between	between	IN
cord-018089-m94q75xn	167	12	influenza	influenza	NN
cord-018089-m94q75xn	167	13	virus	virus	NN
cord-018089-m94q75xn	167	14	and	and	CC
cord-018089-m94q75xn	167	15	Staphylococcus	Staphylococcus	NNP
cord-018089-m94q75xn	167	16	aureus	aureus	NN
cord-018089-m94q75xn	167	17	,	,	,
cord-018089-m94q75xn	167	18	accounting	account	VBG
cord-018089-m94q75xn	167	19	for	for	IN
cord-018089-m94q75xn	167	20	34	34	CD
cord-018089-m94q75xn	167	21	%	%	NN
cord-018089-m94q75xn	167	22	of	of	IN
cord-018089-m94q75xn	167	23	pediatric	pediatric	JJ
cord-018089-m94q75xn	167	24	deaths	death	NNS
cord-018089-m94q75xn	167	25	reported	report	VBN
cord-018089-m94q75xn	167	26	to	to	IN
cord-018089-m94q75xn	167	27	the	the	DT
cord-018089-m94q75xn	167	28	CDC	CDC	NNP
cord-018089-m94q75xn	167	29	during	during	IN
cord-018089-m94q75xn	167	30	the	the	DT
cord-018089-m94q75xn	167	31	2006	2006	CD
cord-018089-m94q75xn	167	32	-	-	SYM
cord-018089-m94q75xn	167	33	2007	2007	CD
cord-018089-m94q75xn	167	34	influenza	influenza	NN
cord-018089-m94q75xn	167	35	season	season	NN
cord-018089-m94q75xn	167	36	[	[	-LRB-
cord-018089-m94q75xn	167	37	117	117	CD
cord-018089-m94q75xn	167	38	]	]	-RRB-
cord-018089-m94q75xn	167	39	.	.	.
cord-018089-m94q75xn	168	1	In	in	IN
cord-018089-m94q75xn	168	2	one	one	CD
cord-018089-m94q75xn	168	3	case	case	NN
cord-018089-m94q75xn	168	4	series	series	NN
cord-018089-m94q75xn	168	5	,	,	,
cord-018089-m94q75xn	168	6	43	43	CD
cord-018089-m94q75xn	168	7	%	%	NN
cord-018089-m94q75xn	168	8	of	of	IN
cord-018089-m94q75xn	168	9	coinfected	coinfected	JJ
cord-018089-m94q75xn	168	10	cases	case	NNS
cord-018089-m94q75xn	168	11	involved	involve	VBD
cord-018089-m94q75xn	168	12	methicillin	methicillin	NN
cord-018089-m94q75xn	168	13	-	-	HYPH
cord-018089-m94q75xn	168	14	resistant	resistant	JJ
cord-018089-m94q75xn	168	15	S.	S.	NNP
cord-018089-m94q75xn	168	16	aureus	aureus	NN
cord-018089-m94q75xn	168	17	,	,	,
cord-018089-m94q75xn	168	18	thus	thus	RB
cord-018089-m94q75xn	168	19	contributing	contribute	VBG
cord-018089-m94q75xn	168	20	to	to	IN
cord-018089-m94q75xn	168	21	management	management	NN
cord-018089-m94q75xn	168	22	challenges	challenge	NNS
cord-018089-m94q75xn	168	23	for	for	IN
cord-018089-m94q75xn	168	24	these	these	DT
cord-018089-m94q75xn	168	25	patients	patient	NNS
cord-018089-m94q75xn	168	26	.	.	.
cord-018089-m94q75xn	169	1	Coinfection	Coinfection	NNP
cord-018089-m94q75xn	169	2	was	be	VBD
cord-018089-m94q75xn	169	3	also	also	RB
cord-018089-m94q75xn	169	4	associated	associate	VBN
cord-018089-m94q75xn	169	5	with	with	IN
cord-018089-m94q75xn	169	6	a	a	DT
cord-018089-m94q75xn	169	7	worse	bad	JJR
cord-018089-m94q75xn	169	8	prognosis	prognosis	NN
cord-018089-m94q75xn	169	9	compared	compare	VBN
cord-018089-m94q75xn	169	10	with	with	IN
cord-018089-m94q75xn	169	11	influenza	influenza	NN
cord-018089-m94q75xn	169	12	virus	virus	NN
cord-018089-m94q75xn	169	13	or	or	CC
cord-018089-m94q75xn	169	14	S.	S.	NNP
cord-018089-m94q75xn	169	15	aureus	aureus	NN
cord-018089-m94q75xn	169	16	infection	infection	NN
cord-018089-m94q75xn	169	17	alone	alone	RB
cord-018089-m94q75xn	169	18	[	[	-LRB-
cord-018089-m94q75xn	169	19	118	118	CD
cord-018089-m94q75xn	169	20	]	]	-RRB-
cord-018089-m94q75xn	169	21	.	.	.
cord-018089-m94q75xn	170	1	To	to	IN
cord-018089-m94q75xn	170	2	date	date	NN
cord-018089-m94q75xn	170	3	,	,	,
cord-018089-m94q75xn	170	4	secondary	secondary	JJ
cord-018089-m94q75xn	170	5	bacterial	bacterial	JJ
cord-018089-m94q75xn	170	6	lower	low	JJR
cord-018089-m94q75xn	170	7	respiratory	respiratory	JJ
cord-018089-m94q75xn	170	8	tract	tract	NN
cord-018089-m94q75xn	170	9	infection	infection	NN
cord-018089-m94q75xn	170	10	has	have	VBZ
cord-018089-m94q75xn	170	11	not	not	RB
cord-018089-m94q75xn	170	12	been	be	VBN
cord-018089-m94q75xn	170	13	a	a	DT
cord-018089-m94q75xn	170	14	dominant	dominant	JJ
cord-018089-m94q75xn	170	15	feature	feature	NN
cord-018089-m94q75xn	170	16	in	in	IN
cord-018089-m94q75xn	170	17	adults	adult	NNS
cord-018089-m94q75xn	170	18	during	during	IN
cord-018089-m94q75xn	170	19	the	the	DT
cord-018089-m94q75xn	170	20	current	current	JJ
cord-018089-m94q75xn	170	21	2009	2009	CD
cord-018089-m94q75xn	170	22	pandemic	pandemic	NN
cord-018089-m94q75xn	170	23	but	but	CC
cord-018089-m94q75xn	170	24	has	have	VBZ
cord-018089-m94q75xn	170	25	been	be	VBN
cord-018089-m94q75xn	170	26	described	describe	VBN
cord-018089-m94q75xn	170	27	in	in	IN
cord-018089-m94q75xn	170	28	children	child	NNS
cord-018089-m94q75xn	170	29	[	[	-LRB-
cord-018089-m94q75xn	170	30	119	119	CD
cord-018089-m94q75xn	170	31	]	]	-RRB-
cord-018089-m94q75xn	170	32	.	.	.
cord-018089-m94q75xn	171	1	Severe	severe	JJ
cord-018089-m94q75xn	171	2	pandemic	pandemic	NN
cord-018089-m94q75xn	171	3	2009	2009	CD
cord-018089-m94q75xn	172	1	influenza	influenza	NN
cord-018089-m94q75xn	172	2	has	have	VBZ
cord-018089-m94q75xn	172	3	been	be	VBN
cord-018089-m94q75xn	172	4	predominantly	predominantly	RB
cord-018089-m94q75xn	172	5	associated	associate	VBN
cord-018089-m94q75xn	172	6	with	with	IN
cord-018089-m94q75xn	172	7	viral	viral	JJ
cord-018089-m94q75xn	172	8	pneumonitis	pneumonitis	NN
cord-018089-m94q75xn	172	9	and	and	CC
cord-018089-m94q75xn	172	10	subsequent	subsequent	JJ
cord-018089-m94q75xn	172	11	ALI	ALI	NNP
cord-018089-m94q75xn	172	12	,	,	,
cord-018089-m94q75xn	172	13	particularly	particularly	RB
cord-018089-m94q75xn	172	14	in	in	IN
cord-018089-m94q75xn	172	15	pregnant	pregnant	JJ
cord-018089-m94q75xn	172	16	women	woman	NNS
cord-018089-m94q75xn	172	17	in	in	IN
cord-018089-m94q75xn	172	18	their	-PRON-	PRP$
cord-018089-m94q75xn	172	19	third	third	JJ
cord-018089-m94q75xn	172	20	trimester	trimester	NN
cord-018089-m94q75xn	172	21	[	[	-LRB-
cord-018089-m94q75xn	172	22	120	120	CD
cord-018089-m94q75xn	172	23	]	]	-RRB-
cord-018089-m94q75xn	172	24	and	and	CC
cord-018089-m94q75xn	172	25	indigeous	indigeous	JJ
cord-018089-m94q75xn	172	26	people	people	NNS
cord-018089-m94q75xn	172	27	including	include	VBG
cord-018089-m94q75xn	172	28	Aborigines	Aborigines	NNPS
cord-018089-m94q75xn	172	29	in	in	IN
cord-018089-m94q75xn	172	30	Australia	Australia	NNP
cord-018089-m94q75xn	172	31	[	[	-LRB-
cord-018089-m94q75xn	172	32	121	121	CD
cord-018089-m94q75xn	172	33	]	]	-RRB-
cord-018089-m94q75xn	172	34	,	,	,
cord-018089-m94q75xn	172	35	Maoris	Maoris	NNPS
cord-018089-m94q75xn	172	36	and	and	CC
cord-018089-m94q75xn	172	37	Pacific	Pacific	NNP
cord-018089-m94q75xn	172	38	Islanders	Islanders	NNPS
cord-018089-m94q75xn	172	39	in	in	IN
cord-018089-m94q75xn	172	40	New	New	NNP
cord-018089-m94q75xn	172	41	Zealand	Zealand	NNP
cord-018089-m94q75xn	172	42	[	[	-LRB-
cord-018089-m94q75xn	172	43	122	122	CD
cord-018089-m94q75xn	172	44	]	]	-RRB-
cord-018089-m94q75xn	172	45	,	,	,
cord-018089-m94q75xn	172	46	and	and	CC
cord-018089-m94q75xn	172	47	First	First	NNP
cord-018089-m94q75xn	172	48	Nations	Nations	NNPS
cord-018089-m94q75xn	172	49	People	People	NNPS
cord-018089-m94q75xn	172	50	in	in	IN
cord-018089-m94q75xn	172	51	Canada	Canada	NNP
cord-018089-m94q75xn	172	52	[	[	-LRB-
cord-018089-m94q75xn	172	53	123	123	CD
cord-018089-m94q75xn	172	54	]	]	-RRB-
cord-018089-m94q75xn	172	55	.	.	.
cord-018089-m94q75xn	173	1	Few	few	JJ
cord-018089-m94q75xn	173	2	human	human	JJ
cord-018089-m94q75xn	173	3	histopathological	histopathological	JJ
cord-018089-m94q75xn	173	4	studies	study	NNS
cord-018089-m94q75xn	173	5	of	of	IN
cord-018089-m94q75xn	173	6	uncomplicated	uncomplicated	JJ
cord-018089-m94q75xn	173	7	influenza	influenza	NN
cord-018089-m94q75xn	173	8	exist	exist	VBP
cord-018089-m94q75xn	173	9	.	.	.
cord-018089-m94q75xn	174	1	Pathological	pathological	JJ
cord-018089-m94q75xn	174	2	findings	finding	NNS
cord-018089-m94q75xn	174	3	from	from	IN
cord-018089-m94q75xn	174	4	postmortem	postmortem	JJ
cord-018089-m94q75xn	174	5	examination	examination	NN
cord-018089-m94q75xn	174	6	of	of	IN
cord-018089-m94q75xn	174	7	47	47	CD
cord-018089-m94q75xn	174	8	fatal	fatal	JJ
cord-018089-m94q75xn	174	9	pediatric	pediatric	JJ
cord-018089-m94q75xn	174	10	influenza	influenza	NN
cord-018089-m94q75xn	174	11	A	a	DT
cord-018089-m94q75xn	174	12	cases	case	NNS
cord-018089-m94q75xn	174	13	included	include	VBD
cord-018089-m94q75xn	174	14	major	major	JJ
cord-018089-m94q75xn	174	15	airway	airway	NN
cord-018089-m94q75xn	174	16	congestion	congestion	NN
cord-018089-m94q75xn	174	17	(	(	-LRB-
cord-018089-m94q75xn	174	18	90	90	CD
cord-018089-m94q75xn	174	19	%	%	NN
cord-018089-m94q75xn	174	20	)	)	-RRB-
cord-018089-m94q75xn	174	21	,	,	,
cord-018089-m94q75xn	174	22	inflammation	inflammation	NN
cord-018089-m94q75xn	174	23	(	(	-LRB-
cord-018089-m94q75xn	174	24	73	73	CD
cord-018089-m94q75xn	174	25	%	%	NN
cord-018089-m94q75xn	174	26	)	)	-RRB-
cord-018089-m94q75xn	174	27	,	,	,
cord-018089-m94q75xn	174	28	and	and	CC
cord-018089-m94q75xn	174	29	necrosis	necrosis	NN
cord-018089-m94q75xn	174	30	(	(	-LRB-
cord-018089-m94q75xn	174	31	50	50	CD
cord-018089-m94q75xn	174	32	%	%	NN
cord-018089-m94q75xn	174	33	)	)	-RRB-
cord-018089-m94q75xn	174	34	[	[	-LRB-
cord-018089-m94q75xn	174	35	112	112	CD
cord-018089-m94q75xn	174	36	]	]	-RRB-
cord-018089-m94q75xn	174	37	.	.	.
cord-018089-m94q75xn	175	1	Lower	low	JJR
cord-018089-m94q75xn	175	2	airway	airway	NN
cord-018089-m94q75xn	175	3	pathology	pathology	NN
cord-018089-m94q75xn	175	4	included	include	VBD
cord-018089-m94q75xn	175	5	hyaline	hyaline	JJ
cord-018089-m94q75xn	175	6	membranes	membrane	NNS
cord-018089-m94q75xn	175	7	(	(	-LRB-
cord-018089-m94q75xn	175	8	67	67	CD
cord-018089-m94q75xn	175	9	%	%	NN
cord-018089-m94q75xn	175	10	)	)	-RRB-
cord-018089-m94q75xn	175	11	,	,	,
cord-018089-m94q75xn	175	12	interstitial	interstitial	JJ
cord-018089-m94q75xn	175	13	cellular	cellular	NN
cord-018089-m94q75xn	175	14	infiltrates	infiltrate	NNS
cord-018089-m94q75xn	175	15	(	(	-LRB-
cord-018089-m94q75xn	175	16	67	67	CD
cord-018089-m94q75xn	175	17	%	%	NN
cord-018089-m94q75xn	175	18	)	)	-RRB-
cord-018089-m94q75xn	175	19	,	,	,
cord-018089-m94q75xn	175	20	and	and	CC
cord-018089-m94q75xn	175	21	diffuse	diffuse	VB
cord-018089-m94q75xn	175	22	alveolar	alveolar	NN
cord-018089-m94q75xn	175	23	damage	damage	NN
cord-018089-m94q75xn	175	24	(	(	-LRB-
cord-018089-m94q75xn	175	25	DAD	DAD	NNP
cord-018089-m94q75xn	175	26	)	)	-RRB-
cord-018089-m94q75xn	175	27	.	.	.
cord-018089-m94q75xn	176	1	Secondary	secondary	JJ
cord-018089-m94q75xn	176	2	pneumonia	pneumonia	NN
cord-018089-m94q75xn	176	3	,	,	,
cord-018089-m94q75xn	176	4	intraalveolar	intraalveolar	NNP
cord-018089-m94q75xn	176	5	hemorrhage	hemorrhage	NN
cord-018089-m94q75xn	176	6	,	,	,
cord-018089-m94q75xn	176	7	and	and	CC
cord-018089-m94q75xn	176	8	viral	viral	JJ
cord-018089-m94q75xn	176	9	pneumonitis	pneumonitis	NN
cord-018089-m94q75xn	176	10	were	be	VBD
cord-018089-m94q75xn	176	11	noted	note	VBN
cord-018089-m94q75xn	176	12	in	in	IN
cord-018089-m94q75xn	176	13	a	a	DT
cord-018089-m94q75xn	176	14	quarter	quarter	NN
cord-018089-m94q75xn	176	15	of	of	IN
cord-018089-m94q75xn	176	16	cases	case	NNS
cord-018089-m94q75xn	176	17	[	[	-LRB-
cord-018089-m94q75xn	176	18	112	112	CD
cord-018089-m94q75xn	176	19	]	]	-RRB-
cord-018089-m94q75xn	176	20	.	.	.
cord-018089-m94q75xn	177	1	Fulminant	Fulminant	NNP
cord-018089-m94q75xn	177	2	DAD	DAD	NNP
cord-018089-m94q75xn	177	3	with	with	IN
cord-018089-m94q75xn	177	4	acute	acute	JJ
cord-018089-m94q75xn	177	5	alveolar	alveolar	JJ
cord-018089-m94q75xn	177	6	hemorrhage	hemorrhage	NN
cord-018089-m94q75xn	177	7	and	and	CC
cord-018089-m94q75xn	177	8	necrosis	necrosis	NN
cord-018089-m94q75xn	177	9	followed	follow	VBN
cord-018089-m94q75xn	177	10	by	by	IN
cord-018089-m94q75xn	177	11	paucicellular	paucicellular	JJ
cord-018089-m94q75xn	177	12	fibrosis	fibrosis	NN
cord-018089-m94q75xn	177	13	and	and	CC
cord-018089-m94q75xn	177	14	hyaline	hyaline	JJ
cord-018089-m94q75xn	177	15	membrane	membrane	NN
cord-018089-m94q75xn	177	16	formation	formation	NN
cord-018089-m94q75xn	177	17	is	be	VBZ
cord-018089-m94q75xn	177	18	observed	observe	VBN
cord-018089-m94q75xn	177	19	in	in	IN
cord-018089-m94q75xn	177	20	H5N1infected	h5n1infecte	VBN
cord-018089-m94q75xn	177	21	human	human	JJ
cord-018089-m94q75xn	177	22	lungs	lung	NNS
cord-018089-m94q75xn	177	23	[	[	-LRB-
cord-018089-m94q75xn	177	24	124	124	CD
cord-018089-m94q75xn	177	25	]	]	-RRB-
cord-018089-m94q75xn	177	26	.	.	.
cord-018089-m94q75xn	178	1	Extrapulmonary	Extrapulmonary	NNP
cord-018089-m94q75xn	178	2	pathology	pathology	NN
cord-018089-m94q75xn	178	3	includes	include	VBZ
cord-018089-m94q75xn	178	4	reactive	reactive	JJ
cord-018089-m94q75xn	178	5	hemophagocytosis	hemophagocytosis	NN
cord-018089-m94q75xn	178	6	in	in	IN
cord-018089-m94q75xn	178	7	the	the	DT
cord-018089-m94q75xn	178	8	hilar	hilar	JJ
cord-018089-m94q75xn	178	9	lymph	lymph	NN
cord-018089-m94q75xn	178	10	nodes	node	NNS
cord-018089-m94q75xn	178	11	,	,	,
cord-018089-m94q75xn	178	12	bone	bone	NN
cord-018089-m94q75xn	178	13	marrow	marrow	NN
cord-018089-m94q75xn	178	14	,	,	,
cord-018089-m94q75xn	178	15	liver	liver	NN
cord-018089-m94q75xn	178	16	,	,	,
cord-018089-m94q75xn	178	17	and	and	CC
cord-018089-m94q75xn	178	18	spleen	spleen	NNS
cord-018089-m94q75xn	178	19	[	[	-LRB-
cord-018089-m94q75xn	178	20	125	125	CD
cord-018089-m94q75xn	178	21	]	]	-RRB-
cord-018089-m94q75xn	178	22	;	;	:
cord-018089-m94q75xn	178	23	white	white	JJ
cord-018089-m94q75xn	178	24	matter	matter	NN
cord-018089-m94q75xn	178	25	demyelination	demyelination	NN
cord-018089-m94q75xn	178	26	[	[	-LRB-
cord-018089-m94q75xn	178	27	124	124	CD
cord-018089-m94q75xn	178	28	]	]	-RRB-
cord-018089-m94q75xn	178	29	and	and	CC
cord-018089-m94q75xn	178	30	cerebral	cerebral	JJ
cord-018089-m94q75xn	178	31	necrosis	necrosis	NN
cord-018089-m94q75xn	178	32	[	[	-LRB-
cord-018089-m94q75xn	178	33	101	101	CD
cord-018089-m94q75xn	178	34	]	]	-RRB-
cord-018089-m94q75xn	178	35	;	;	:
cord-018089-m94q75xn	178	36	and	and	CC
cord-018089-m94q75xn	178	37	acute	acute	JJ
cord-018089-m94q75xn	178	38	tubular	tubular	JJ
cord-018089-m94q75xn	178	39	necrosis	necrosis	NN
cord-018089-m94q75xn	178	40	of	of	IN
cord-018089-m94q75xn	178	41	the	the	DT
cord-018089-m94q75xn	178	42	kidneys	kidney	NNS
cord-018089-m94q75xn	178	43	[	[	-LRB-
cord-018089-m94q75xn	178	44	113	113	CD
cord-018089-m94q75xn	178	45	]	]	-RRB-
cord-018089-m94q75xn	178	46	.	.	.
cord-018089-m94q75xn	179	1	Despite	despite	IN
cord-018089-m94q75xn	179	2	the	the	DT
cord-018089-m94q75xn	179	3	presence	presence	NN
cord-018089-m94q75xn	179	4	of	of	IN
cord-018089-m94q75xn	179	5	diarrhea	diarrhea	NN
cord-018089-m94q75xn	179	6	and	and	CC
cord-018089-m94q75xn	179	7	H5N1	H5N1	NNP
cord-018089-m94q75xn	179	8	virus	virus	NN
cord-018089-m94q75xn	179	9	replication	replication	NN
cord-018089-m94q75xn	179	10	in	in	IN
cord-018089-m94q75xn	179	11	the	the	DT
cord-018089-m94q75xn	179	12	gastrointestinal	gastrointestinal	JJ
cord-018089-m94q75xn	179	13	tract	tract	NN
cord-018089-m94q75xn	179	14	of	of	IN
cord-018089-m94q75xn	179	15	humans	human	NNS
cord-018089-m94q75xn	179	16	,	,	,
cord-018089-m94q75xn	179	17	no	no	DT
cord-018089-m94q75xn	179	18	pathological	pathological	JJ
cord-018089-m94q75xn	179	19	lesions	lesion	NNS
cord-018089-m94q75xn	179	20	have	have	VBP
cord-018089-m94q75xn	179	21	been	be	VBN
cord-018089-m94q75xn	179	22	described	describe	VBN
cord-018089-m94q75xn	179	23	in	in	IN
cord-018089-m94q75xn	179	24	the	the	DT
cord-018089-m94q75xn	179	25	bowel	bowel	NN
cord-018089-m94q75xn	179	26	[	[	-LRB-
cord-018089-m94q75xn	179	27	101	101	CD
cord-018089-m94q75xn	179	28	,	,	,
cord-018089-m94q75xn	179	29	114	114	CD
cord-018089-m94q75xn	179	30	]	]	-RRB-
cord-018089-m94q75xn	179	31	.	.	.
cord-018089-m94q75xn	180	1	Immune	immune	JJ
cord-018089-m94q75xn	180	2	dysregulation	dysregulation	NN
cord-018089-m94q75xn	180	3	has	have	VBZ
cord-018089-m94q75xn	180	4	been	be	VBN
cord-018089-m94q75xn	180	5	implicated	implicate	VBN
cord-018089-m94q75xn	180	6	in	in	IN
cord-018089-m94q75xn	180	7	the	the	DT
cord-018089-m94q75xn	180	8	pathogenesis	pathogenesis	NN
cord-018089-m94q75xn	180	9	of	of	IN
cord-018089-m94q75xn	180	10	ARDS	ARDS	NNP
cord-018089-m94q75xn	180	11	and	and	CC
cord-018089-m94q75xn	180	12	reactive	reactive	JJ
cord-018089-m94q75xn	180	13	hemophagocytosis	hemophagocytosis	NN
cord-018089-m94q75xn	180	14	.	.	.
cord-018089-m94q75xn	181	1	Elevated	elevated	JJ
cord-018089-m94q75xn	181	2	levels	level	NNS
cord-018089-m94q75xn	181	3	of	of	IN
cord-018089-m94q75xn	181	4	neutrophil	neutrophil	NN
cord-018089-m94q75xn	181	5	,	,	,
cord-018089-m94q75xn	181	6	monocyte	monocyte	NNP
cord-018089-m94q75xn	181	7	,	,	,
cord-018089-m94q75xn	181	8	and	and	CC
cord-018089-m94q75xn	181	9	macrophage	macrophage	NN
cord-018089-m94q75xn	181	10	chemoattractants	chemoattractant	NNS
cord-018089-m94q75xn	181	11	(	(	-LRB-
cord-018089-m94q75xn	181	12	IL-8	IL-8	NNP
cord-018089-m94q75xn	181	13	,	,	,
cord-018089-m94q75xn	181	14	IP-10	IP-10	NNP
cord-018089-m94q75xn	181	15	,	,	,
cord-018089-m94q75xn	181	16	MIG	MIG	NNP
cord-018089-m94q75xn	181	17	,	,	,
cord-018089-m94q75xn	181	18	and	and	CC
cord-018089-m94q75xn	181	19	MCP-1	MCP-1	NNP
cord-018089-m94q75xn	181	20	)	)	-RRB-
cord-018089-m94q75xn	181	21	and	and	CC
cord-018089-m94q75xn	181	22	proinflammatory	proinflammatory	JJ
cord-018089-m94q75xn	181	23	cytokines	cytokine	NNS
cord-018089-m94q75xn	181	24	(	(	-LRB-
cord-018089-m94q75xn	181	25	IL-10	IL-10	NNP
cord-018089-m94q75xn	181	26	,	,	,
cord-018089-m94q75xn	181	27	IL-6	IL-6	NNP
cord-018089-m94q75xn	181	28	,	,	,
cord-018089-m94q75xn	181	29	and	and	CC
cord-018089-m94q75xn	181	30	IFN	IFN	NNP
cord-018089-m94q75xn	181	31	-	-	HYPH
cord-018089-m94q75xn	181	32	g	g	NNP
cord-018089-m94q75xn	181	33	)	)	-RRB-
cord-018089-m94q75xn	181	34	are	be	VBP
cord-018089-m94q75xn	181	35	observed	observe	VBN
cord-018089-m94q75xn	181	36	in	in	IN
cord-018089-m94q75xn	181	37	H5N1-infected	h5n1-infected	JJ
cord-018089-m94q75xn	181	38	humans	human	NNS
cord-018089-m94q75xn	181	39	[	[	-LRB-
cord-018089-m94q75xn	181	40	95	95	CD
cord-018089-m94q75xn	181	41	]	]	-RRB-
cord-018089-m94q75xn	181	42	.	.	.
cord-018089-m94q75xn	182	1	In	in	IN
cord-018089-m94q75xn	182	2	addition	addition	NN
cord-018089-m94q75xn	182	3	,	,	,
cord-018089-m94q75xn	182	4	increased	increase	VBN
cord-018089-m94q75xn	182	5	levels	level	NNS
cord-018089-m94q75xn	182	6	of	of	IN
cord-018089-m94q75xn	182	7	IL-2	IL-2	NNP
cord-018089-m94q75xn	182	8	(	(	-LRB-
cord-018089-m94q75xn	182	9	in	in	IN
cord-018089-m94q75xn	182	10	a	a	DT
cord-018089-m94q75xn	182	11	human	human	JJ
cord-018089-m94q75xn	182	12	case	case	NN
cord-018089-m94q75xn	182	13	)	)	-RRB-
cord-018089-m94q75xn	182	14	[	[	-LRB-
cord-018089-m94q75xn	182	15	113	113	CD
cord-018089-m94q75xn	182	16	]	]	-RRB-
cord-018089-m94q75xn	182	17	and	and	CC
cord-018089-m94q75xn	182	18	RANTES	RANTES	NNPS
cord-018089-m94q75xn	182	19	(	(	-LRB-
cord-018089-m94q75xn	182	20	in	in	IN
cord-018089-m94q75xn	182	21	primary	primary	JJ
cord-018089-m94q75xn	182	22	human	human	JJ
cord-018089-m94q75xn	182	23	alveolar	alveolar	NN
cord-018089-m94q75xn	182	24	and	and	CC
cord-018089-m94q75xn	182	25	bronchial	bronchial	JJ
cord-018089-m94q75xn	182	26	epithelial	epithelial	JJ
cord-018089-m94q75xn	182	27	cells	cell	NNS
cord-018089-m94q75xn	182	28	)	)	-RRB-
cord-018089-m94q75xn	182	29	[	[	-LRB-
cord-018089-m94q75xn	182	30	126	126	CD
cord-018089-m94q75xn	182	31	]	]	-RRB-
cord-018089-m94q75xn	182	32	have	have	VBP
cord-018089-m94q75xn	182	33	also	also	RB
cord-018089-m94q75xn	182	34	been	be	VBN
cord-018089-m94q75xn	182	35	reported	report	VBN
cord-018089-m94q75xn	182	36	.	.	.
cord-018089-m94q75xn	183	1	Contribution	contribution	NN
cord-018089-m94q75xn	183	2	of	of	IN
cord-018089-m94q75xn	183	3	proinflammatory	proinflammatory	JJ
cord-018089-m94q75xn	183	4	mediators	mediator	NNS
cord-018089-m94q75xn	183	5	to	to	IN
cord-018089-m94q75xn	183	6	lung	lung	NN
cord-018089-m94q75xn	183	7	pathology	pathology	NN
cord-018089-m94q75xn	183	8	has	have	VBZ
cord-018089-m94q75xn	183	9	also	also	RB
cord-018089-m94q75xn	183	10	been	be	VBN
cord-018089-m94q75xn	183	11	demonstrated	demonstrate	VBN
cord-018089-m94q75xn	183	12	using	use	VBG
cord-018089-m94q75xn	183	13	Toll	Toll	NNP
cord-018089-m94q75xn	183	14	-	-	HYPH
cord-018089-m94q75xn	183	15	like	like	JJ
cord-018089-m94q75xn	183	16	receptor	receptor	NN
cord-018089-m94q75xn	183	17	3	3	CD
cord-018089-m94q75xn	183	18	knockout	knockout	NN
cord-018089-m94q75xn	183	19	mice	mouse	NNS
cord-018089-m94q75xn	183	20	infected	infect	VBN
cord-018089-m94q75xn	183	21	with	with	IN
cord-018089-m94q75xn	183	22	mouse	mouse	NN
cord-018089-m94q75xn	183	23	-	-	HYPH
cord-018089-m94q75xn	183	24	adapted	adapt	VBN
cord-018089-m94q75xn	183	25	WSN	WSN	NNP
cord-018089-m94q75xn	183	26	influenza	influenza	NN
cord-018089-m94q75xn	183	27	A	a	DT
cord-018089-m94q75xn	183	28	virus	virus	NN
cord-018089-m94q75xn	183	29	.	.	.
cord-018089-m94q75xn	184	1	These	these	DT
cord-018089-m94q75xn	184	2	mice	mouse	NNS
cord-018089-m94q75xn	184	3	demonstrated	demonstrate	VBD
cord-018089-m94q75xn	184	4	enhanced	enhanced	JJ
cord-018089-m94q75xn	184	5	survival	survival	NN
cord-018089-m94q75xn	184	6	despite	despite	IN
cord-018089-m94q75xn	184	7	higher	high	JJR
cord-018089-m94q75xn	184	8	virus	virus	NN
cord-018089-m94q75xn	184	9	replication	replication	NN
cord-018089-m94q75xn	184	10	and	and	CC
cord-018089-m94q75xn	184	11	lower	low	JJR
cord-018089-m94q75xn	184	12	levels	level	NNS
cord-018089-m94q75xn	184	13	of	of	IN
cord-018089-m94q75xn	184	14	RANTES	rante	NNS
cord-018089-m94q75xn	184	15	,	,	,
cord-018089-m94q75xn	184	16	IL-6	IL-6	NNP
cord-018089-m94q75xn	184	17	,	,	,
cord-018089-m94q75xn	184	18	and	and	CC
cord-018089-m94q75xn	184	19	IL-12p40	IL-12p40	NNP
cord-018089-m94q75xn	184	20	/	/	SYM
cord-018089-m94q75xn	184	21	p70	p70	CD
cord-018089-m94q75xn	184	22	compared	compare	VBN
cord-018089-m94q75xn	184	23	with	with	IN
cord-018089-m94q75xn	184	24	wild	wild	JJ
cord-018089-m94q75xn	184	25	-	-	HYPH
cord-018089-m94q75xn	184	26	type	type	NN
cord-018089-m94q75xn	184	27	mice	mouse	NNS
cord-018089-m94q75xn	184	28	[	[	-LRB-
cord-018089-m94q75xn	184	29	127	127	CD
cord-018089-m94q75xn	184	30	]	]	-RRB-
cord-018089-m94q75xn	184	31	.	.	.
cord-018089-m94q75xn	185	1	Likewise	likewise	RB
cord-018089-m94q75xn	185	2	,	,	,
cord-018089-m94q75xn	185	3	host	host	NN
cord-018089-m94q75xn	185	4	response	response	NN
cord-018089-m94q75xn	185	5	has	have	VBZ
cord-018089-m94q75xn	185	6	been	be	VBN
cord-018089-m94q75xn	185	7	implicated	implicate	VBN
cord-018089-m94q75xn	185	8	in	in	IN
cord-018089-m94q75xn	185	9	the	the	DT
cord-018089-m94q75xn	185	10	copathogenesis	copathogenesis	NN
cord-018089-m94q75xn	185	11	of	of	IN
cord-018089-m94q75xn	185	12	bacterial	bacterial	JJ
cord-018089-m94q75xn	185	13	pneumonia	pneumonia	NN
cord-018089-m94q75xn	185	14	post	post	NN
cord-018089-m94q75xn	185	15	-	-	JJ
cord-018089-m94q75xn	185	16	influenza	influenza	JJ
cord-018089-m94q75xn	185	17	virus	virus	NN
cord-018089-m94q75xn	185	18	infection	infection	NN
cord-018089-m94q75xn	185	19	.	.	.
cord-018089-m94q75xn	186	1	Specifically	specifically	RB
cord-018089-m94q75xn	186	2	,	,	,
cord-018089-m94q75xn	186	3	sensitization	sensitization	NN
cord-018089-m94q75xn	186	4	by	by	IN
cord-018089-m94q75xn	186	5	type	type	NN
cord-018089-m94q75xn	186	6	I	-PRON-	PRP
cord-018089-m94q75xn	186	7	interferons	interferon	NNS
cord-018089-m94q75xn	186	8	[	[	-LRB-
cord-018089-m94q75xn	186	9	128	128	CD
cord-018089-m94q75xn	186	10	]	]	-RRB-
cord-018089-m94q75xn	187	1	,	,	,
cord-018089-m94q75xn	187	2	induction	induction	NN
cord-018089-m94q75xn	187	3	of	of	IN
cord-018089-m94q75xn	187	4	IL-10	IL-10	NNP
cord-018089-m94q75xn	187	5	[	[	-LRB-
cord-018089-m94q75xn	187	6	129	129	CD
cord-018089-m94q75xn	187	7	]	]	-RRB-
cord-018089-m94q75xn	187	8	,	,	,
cord-018089-m94q75xn	187	9	and	and	CC
cord-018089-m94q75xn	187	10	upregulation	upregulation	NN
cord-018089-m94q75xn	187	11	of	of	IN
cord-018089-m94q75xn	187	12	interferon	interferon	NN
cord-018089-m94q75xn	187	13	-	-	:
cord-018089-m94q75xn	187	14	a	a	DT
cord-018089-m94q75xn	187	15	[	[	-LRB-
cord-018089-m94q75xn	187	16	130	130	CD
cord-018089-m94q75xn	187	17	]	]	-RRB-
cord-018089-m94q75xn	187	18	have	have	VBP
cord-018089-m94q75xn	187	19	been	be	VBN
cord-018089-m94q75xn	187	20	linked	link	VBN
cord-018089-m94q75xn	187	21	to	to	IN
cord-018089-m94q75xn	187	22	secondary	secondary	JJ
cord-018089-m94q75xn	187	23	bacterial	bacterial	JJ
cord-018089-m94q75xn	187	24	pneumonia	pneumonia	NN
cord-018089-m94q75xn	187	25	after	after	IN
cord-018089-m94q75xn	187	26	influenza	influenza	NN
cord-018089-m94q75xn	187	27	virus	virus	NN
cord-018089-m94q75xn	187	28	infection	infection	NN
cord-018089-m94q75xn	187	29	.	.	.
cord-018089-m94q75xn	188	1	Viral	viral	JJ
cord-018089-m94q75xn	188	2	determinants	determinant	NNS
cord-018089-m94q75xn	188	3	for	for	IN
cord-018089-m94q75xn	188	4	copathogenesis	copathogenesis	NN
cord-018089-m94q75xn	188	5	have	have	VBP
cord-018089-m94q75xn	188	6	also	also	RB
cord-018089-m94q75xn	188	7	been	be	VBN
cord-018089-m94q75xn	188	8	elucidated	elucidate	VBN
cord-018089-m94q75xn	188	9	and	and	CC
cord-018089-m94q75xn	188	10	include	include	VB
cord-018089-m94q75xn	188	11	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	188	12	and	and	CC
cord-018089-m94q75xn	188	13	viral	viral	JJ
cord-018089-m94q75xn	188	14	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	188	15	[	[	-LRB-
cord-018089-m94q75xn	188	16	131	131	CD
cord-018089-m94q75xn	188	17	,	,	,
cord-018089-m94q75xn	188	18	132	132	CD
cord-018089-m94q75xn	188	19	]	]	-RRB-
cord-018089-m94q75xn	188	20	.	.	.
cord-018089-m94q75xn	189	1	The	the	DT
cord-018089-m94q75xn	189	2	HA	HA	NNP
cord-018089-m94q75xn	189	3	,	,	,
cord-018089-m94q75xn	189	4	PA	PA	NNP
cord-018089-m94q75xn	189	5	,	,	,
cord-018089-m94q75xn	189	6	PB1	PB1	NNP
cord-018089-m94q75xn	189	7	,	,	,
cord-018089-m94q75xn	189	8	PB2	PB2	NNP
cord-018089-m94q75xn	189	9	,	,	,
cord-018089-m94q75xn	189	10	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	189	11	,	,	,
cord-018089-m94q75xn	189	12	NA	NA	NNP
cord-018089-m94q75xn	189	13	,	,	,
cord-018089-m94q75xn	189	14	and	and	CC
cord-018089-m94q75xn	189	15	NS1	ns1	NN
cord-018089-m94q75xn	189	16	gene	gene	NN
cord-018089-m94q75xn	189	17	products	product	NNS
cord-018089-m94q75xn	189	18	have	have	VBP
cord-018089-m94q75xn	189	19	been	be	VBN
cord-018089-m94q75xn	189	20	implicated	implicate	VBN
cord-018089-m94q75xn	189	21	in	in	IN
cord-018089-m94q75xn	189	22	virulence	virulence	NN
cord-018089-m94q75xn	189	23	.	.	.
cord-018089-m94q75xn	190	1	Virulence	virulence	NN
cord-018089-m94q75xn	190	2	determinants	determinant	NNS
cord-018089-m94q75xn	190	3	have	have	VBP
cord-018089-m94q75xn	190	4	been	be	VBN
cord-018089-m94q75xn	190	5	explored	explore	VBN
cord-018089-m94q75xn	190	6	using	use	VBG
cord-018089-m94q75xn	190	7	the	the	DT
cord-018089-m94q75xn	190	8	reverse	reverse	JJ
cord-018089-m94q75xn	190	9	genetic	genetic	JJ
cord-018089-m94q75xn	190	10	system	system	NN
cord-018089-m94q75xn	190	11	for	for	IN
cord-018089-m94q75xn	190	12	influenza	influenza	NN
cord-018089-m94q75xn	190	13	viruses	virus	NNS
cord-018089-m94q75xn	190	14	and	and	CC
cord-018089-m94q75xn	190	15	mammalian	mammalian	JJ
cord-018089-m94q75xn	190	16	(	(	-LRB-
cord-018089-m94q75xn	190	17	ferret	ferret	NN
cord-018089-m94q75xn	190	18	and	and	CC
cord-018089-m94q75xn	190	19	mouse	mouse	NN
cord-018089-m94q75xn	190	20	)	)	-RRB-
cord-018089-m94q75xn	190	21	models	model	NNS
cord-018089-m94q75xn	190	22	for	for	IN
cord-018089-m94q75xn	190	23	influenza	influenza	NN
cord-018089-m94q75xn	190	24	virus	virus	NN
cord-018089-m94q75xn	190	25	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	190	26	.	.	.
cord-018089-m94q75xn	191	1	The	the	DT
cord-018089-m94q75xn	191	2	polymerase	polymerase	NN
cord-018089-m94q75xn	191	3	gene	gene	NN
cord-018089-m94q75xn	191	4	complex	complex	NN
cord-018089-m94q75xn	191	5	,	,	,
cord-018089-m94q75xn	191	6	consisting	consist	VBG
cord-018089-m94q75xn	191	7	of	of	IN
cord-018089-m94q75xn	191	8	PA	PA	NNP
cord-018089-m94q75xn	191	9	,	,	,
cord-018089-m94q75xn	191	10	PB1	PB1	NNP
cord-018089-m94q75xn	191	11	,	,	,
cord-018089-m94q75xn	191	12	and	and	CC
cord-018089-m94q75xn	191	13	PB2	PB2	NNP
cord-018089-m94q75xn	191	14	genes	gene	NNS
cord-018089-m94q75xn	191	15	,	,	,
cord-018089-m94q75xn	191	16	is	be	VBZ
cord-018089-m94q75xn	191	17	involved	involve	VBN
cord-018089-m94q75xn	191	18	in	in	IN
cord-018089-m94q75xn	191	19	replication	replication	NN
cord-018089-m94q75xn	191	20	and	and	CC
cord-018089-m94q75xn	191	21	transcriptional	transcriptional	JJ
cord-018089-m94q75xn	191	22	activity	activity	NN
cord-018089-m94q75xn	191	23	.	.	.
cord-018089-m94q75xn	192	1	A	a	DT
cord-018089-m94q75xn	192	2	single	single	JJ
cord-018089-m94q75xn	192	3	-	-	HYPH
cord-018089-m94q75xn	192	4	gene	gene	NN
cord-018089-m94q75xn	192	5	reassortant	reassortant	NN
cord-018089-m94q75xn	192	6	containing	contain	VBG
cord-018089-m94q75xn	192	7	the	the	DT
cord-018089-m94q75xn	192	8	PB2	PB2	NNP
cord-018089-m94q75xn	192	9	from	from	IN
cord-018089-m94q75xn	192	10	A	A	NNP
cord-018089-m94q75xn	192	11	/	/	SYM
cord-018089-m94q75xn	192	12	Hong	Hong	NNP
cord-018089-m94q75xn	192	13	Kong/483/97	Kong/483/97	NNP
cord-018089-m94q75xn	193	1	(	(	-LRB-
cord-018089-m94q75xn	193	2	H5N1	H5N1	NNP
cord-018089-m94q75xn	193	3	,	,	,
cord-018089-m94q75xn	193	4	which	which	WDT
cord-018089-m94q75xn	193	5	is	be	VBZ
cord-018089-m94q75xn	193	6	fatal	fatal	JJ
cord-018089-m94q75xn	193	7	in	in	IN
cord-018089-m94q75xn	193	8	mice	mouse	NNS
cord-018089-m94q75xn	193	9	)	)	-RRB-
cord-018089-m94q75xn	193	10	in	in	IN
cord-018089-m94q75xn	193	11	the	the	DT
cord-018089-m94q75xn	193	12	background	background	NN
cord-018089-m94q75xn	193	13	of	of	IN
cord-018089-m94q75xn	193	14	A	A	NNP
cord-018089-m94q75xn	193	15	/	/	SYM
cord-018089-m94q75xn	193	16	Hong	Hong	NNP
cord-018089-m94q75xn	193	17	Kong/486/97	Kong/486/97	.
cord-018089-m94q75xn	194	1	(	(	-LRB-
cord-018089-m94q75xn	194	2	H5N1	H5N1	NNP
cord-018089-m94q75xn	194	3	,	,	,
cord-018089-m94q75xn	194	4	causing	cause	VBG
cord-018089-m94q75xn	194	5	mild	mild	JJ
cord-018089-m94q75xn	194	6	respiratory	respiratory	JJ
cord-018089-m94q75xn	194	7	infection	infection	NN
cord-018089-m94q75xn	194	8	in	in	IN
cord-018089-m94q75xn	194	9	mice	mouse	NNS
cord-018089-m94q75xn	194	10	)	)	-RRB-
cord-018089-m94q75xn	194	11	demonstrated	demonstrate	VBD
cord-018089-m94q75xn	194	12	a	a	DT
cord-018089-m94q75xn	194	13	lethal	lethal	JJ
cord-018089-m94q75xn	194	14	phenotype	phenotype	NN
cord-018089-m94q75xn	194	15	in	in	IN
cord-018089-m94q75xn	194	16	this	this	DT
cord-018089-m94q75xn	194	17	animal	animal	NN
cord-018089-m94q75xn	194	18	model	model	NN
cord-018089-m94q75xn	194	19	[	[	-LRB-
cord-018089-m94q75xn	194	20	133	133	CD
cord-018089-m94q75xn	194	21	]	]	-RRB-
cord-018089-m94q75xn	194	22	.	.	.
cord-018089-m94q75xn	195	1	In	in	IN
cord-018089-m94q75xn	195	2	addition	addition	NN
cord-018089-m94q75xn	195	3	,	,	,
cord-018089-m94q75xn	195	4	reassortants	reassortant	NNS
cord-018089-m94q75xn	195	5	containing	contain	VBG
cord-018089-m94q75xn	195	6	polymerase	polymerase	NN
cord-018089-m94q75xn	195	7	complex	complex	JJ
cord-018089-m94q75xn	195	8	genes	gene	NNS
cord-018089-m94q75xn	195	9	from	from	IN
cord-018089-m94q75xn	195	10	A	a	NN
cord-018089-m94q75xn	195	11	/	/	SYM
cord-018089-m94q75xn	195	12	chicken	chicken	NN
cord-018089-m94q75xn	195	13	/	/	SYM
cord-018089-m94q75xn	195	14	Vietnam	Vietnam	NNP
cord-018089-m94q75xn	195	15	/	/	SYM
cord-018089-m94q75xn	195	16	C58/	C58/	NNP
cord-018089-m94q75xn	195	17	04	04	CD
cord-018089-m94q75xn	195	18	(	(	-LRB-
cord-018089-m94q75xn	195	19	H5N1	H5N1	NNP
cord-018089-m94q75xn	195	20	)	)	-RRB-
cord-018089-m94q75xn	195	21	,	,	,
cord-018089-m94q75xn	195	22	a	a	DT
cord-018089-m94q75xn	195	23	nonlethal	nonlethal	JJ
cord-018089-m94q75xn	195	24	virus	virus	NN
cord-018089-m94q75xn	195	25	,	,	,
cord-018089-m94q75xn	195	26	in	in	IN
cord-018089-m94q75xn	195	27	the	the	DT
cord-018089-m94q75xn	195	28	background	background	NN
cord-018089-m94q75xn	195	29	of	of	IN
cord-018089-m94q75xn	195	30	A	a	NN
cord-018089-m94q75xn	195	31	/	/	,
cord-018089-m94q75xn	195	32	Vietnam/1203/04	Vietnam/1203/04	,
cord-018089-m94q75xn	195	33	(	(	-LRB-
cord-018089-m94q75xn	195	34	H5N1	H5N1	NNP
cord-018089-m94q75xn	195	35	)	)	-RRB-
cord-018089-m94q75xn	195	36	influenza	influenza	NN
cord-018089-m94q75xn	195	37	virus	virus	NN
cord-018089-m94q75xn	195	38	isolated	isolate	VBN
cord-018089-m94q75xn	195	39	from	from	IN
cord-018089-m94q75xn	195	40	a	a	DT
cord-018089-m94q75xn	195	41	fatal	fatal	JJ
cord-018089-m94q75xn	195	42	human	human	JJ
cord-018089-m94q75xn	195	43	case	case	NN
cord-018089-m94q75xn	195	44	were	be	VBD
cord-018089-m94q75xn	195	45	attenuated	attenuate	VBN
cord-018089-m94q75xn	195	46	in	in	IN
cord-018089-m94q75xn	195	47	an	an	DT
cord-018089-m94q75xn	195	48	animal	animal	NN
cord-018089-m94q75xn	195	49	model	model	NN
cord-018089-m94q75xn	195	50	[	[	-LRB-
cord-018089-m94q75xn	195	51	134	134	CD
cord-018089-m94q75xn	195	52	]	]	-RRB-
cord-018089-m94q75xn	195	53	.	.	.
cord-018089-m94q75xn	196	1	When	when	WRB
cord-018089-m94q75xn	196	2	a	a	DT
cord-018089-m94q75xn	196	3	single	single	JJ
cord-018089-m94q75xn	196	4	point	point	NN
cord-018089-m94q75xn	196	5	mutation	mutation	NN
cord-018089-m94q75xn	196	6	K627E	k627e	XX
cord-018089-m94q75xn	196	7	in	in	IN
cord-018089-m94q75xn	196	8	the	the	DT
cord-018089-m94q75xn	196	9	PB2	PB2	NNP
cord-018089-m94q75xn	196	10	gene	gene	NN
cord-018089-m94q75xn	196	11	was	be	VBD
cord-018089-m94q75xn	196	12	generated	generate	VBN
cord-018089-m94q75xn	196	13	in	in	IN
cord-018089-m94q75xn	196	14	A/	A/	NNP
cord-018089-m94q75xn	197	1	Vietnam/1203/04	vietnam/1203/04	JJ
cord-018089-m94q75xn	197	2	[	[	-LRB-
cord-018089-m94q75xn	197	3	134	134	CD
cord-018089-m94q75xn	197	4	]	]	-RRB-
cord-018089-m94q75xn	198	1	and	and	CC
cord-018089-m94q75xn	198	2	in	in	IN
cord-018089-m94q75xn	198	3	A	A	NNP
cord-018089-m94q75xn	198	4	/	/	SYM
cord-018089-m94q75xn	198	5	Hong	Hong	NNP
cord-018089-m94q75xn	198	6	Kong/483/97	Kong/483/97	NNP
cord-018089-m94q75xn	198	7	[	[	-LRB-
cord-018089-m94q75xn	198	8	133	133	CD
cord-018089-m94q75xn	198	9	]	]	-RRB-
cord-018089-m94q75xn	198	10	,	,	,
cord-018089-m94q75xn	198	11	virulence	virulence	NN
cord-018089-m94q75xn	198	12	was	be	VBD
cord-018089-m94q75xn	198	13	reduced	reduce	VBN
cord-018089-m94q75xn	198	14	in	in	IN
cord-018089-m94q75xn	198	15	mice	mouse	NNS
cord-018089-m94q75xn	198	16	,	,	,
cord-018089-m94q75xn	198	17	although	although	IN
cord-018089-m94q75xn	198	18	in	in	IN
cord-018089-m94q75xn	198	19	other	other	JJ
cord-018089-m94q75xn	198	20	studies	study	NNS
cord-018089-m94q75xn	198	21	this	this	DT
cord-018089-m94q75xn	198	22	substitution	substitution	NN
cord-018089-m94q75xn	198	23	did	do	VBD
cord-018089-m94q75xn	198	24	not	not	RB
cord-018089-m94q75xn	198	25	reduce	reduce	VB
cord-018089-m94q75xn	198	26	virulence	virulence	NN
cord-018089-m94q75xn	198	27	substantially	substantially	RB
cord-018089-m94q75xn	198	28	[	[	-LRB-
cord-018089-m94q75xn	198	29	135	135	CD
cord-018089-m94q75xn	198	30	]	]	-RRB-
cord-018089-m94q75xn	198	31	.	.	.
cord-018089-m94q75xn	199	1	The	the	DT
cord-018089-m94q75xn	199	2	molecular	molecular	JJ
cord-018089-m94q75xn	199	3	mechanism(s	mechanism(s	NNP
cord-018089-m94q75xn	199	4	)	)	-RRB-
cord-018089-m94q75xn	199	5	responsible	responsible	JJ
cord-018089-m94q75xn	199	6	for	for	IN
cord-018089-m94q75xn	199	7	virulence	virulence	NN
cord-018089-m94q75xn	199	8	have	have	VBP
cord-018089-m94q75xn	199	9	yet	yet	RB
cord-018089-m94q75xn	199	10	to	to	TO
cord-018089-m94q75xn	199	11	be	be	VB
cord-018089-m94q75xn	199	12	completely	completely	RB
cord-018089-m94q75xn	199	13	elucidated	elucidate	VBN
cord-018089-m94q75xn	199	14	.	.	.
cord-018089-m94q75xn	200	1	Enhanced	enhanced	JJ
cord-018089-m94q75xn	200	2	replication	replication	NN
cord-018089-m94q75xn	200	3	of	of	IN
cord-018089-m94q75xn	200	4	viruses	virus	NNS
cord-018089-m94q75xn	200	5	retaining	retain	VBG
cord-018089-m94q75xn	200	6	a	a	DT
cord-018089-m94q75xn	200	7	lysine	lysine	NN
cord-018089-m94q75xn	200	8	at	at	IN
cord-018089-m94q75xn	200	9	position	position	NN
cord-018089-m94q75xn	200	10	627	627	CD
cord-018089-m94q75xn	200	11	in	in	IN
cord-018089-m94q75xn	200	12	PB2	PB2	NNP
cord-018089-m94q75xn	200	13	at	at	IN
cord-018089-m94q75xn	200	14	the	the	DT
cord-018089-m94q75xn	200	15	lower	low	JJR
cord-018089-m94q75xn	200	16	temperatures	temperature	NNS
cord-018089-m94q75xn	200	17	of	of	IN
cord-018089-m94q75xn	200	18	the	the	DT
cord-018089-m94q75xn	200	19	upper	upper	JJ
cord-018089-m94q75xn	200	20	respiratory	respiratory	JJ
cord-018089-m94q75xn	200	21	tract	tract	NN
cord-018089-m94q75xn	200	22	(	(	-LRB-
cord-018089-m94q75xn	200	23	33	33	CD
cord-018089-m94q75xn	200	24	C	c	NN
cord-018089-m94q75xn	200	25	)	)	-RRB-
cord-018089-m94q75xn	200	26	[	[	-LRB-
cord-018089-m94q75xn	200	27	136	136	CD
cord-018089-m94q75xn	200	28	]	]	-RRB-
cord-018089-m94q75xn	200	29	may	may	MD
cord-018089-m94q75xn	200	30	be	be	VB
cord-018089-m94q75xn	200	31	responsible	responsible	JJ
cord-018089-m94q75xn	200	32	for	for	IN
cord-018089-m94q75xn	200	33	robust	robust	JJ
cord-018089-m94q75xn	200	34	transmission	transmission	NN
cord-018089-m94q75xn	200	35	in	in	IN
cord-018089-m94q75xn	200	36	mammals	mammal	NNS
cord-018089-m94q75xn	200	37	[	[	-LRB-
cord-018089-m94q75xn	200	38	137	137	CD
cord-018089-m94q75xn	200	39	]	]	-RRB-
cord-018089-m94q75xn	200	40	.	.	.
cord-018089-m94q75xn	201	1	This	this	DT
cord-018089-m94q75xn	201	2	theory	theory	NN
cord-018089-m94q75xn	201	3	is	be	VBZ
cord-018089-m94q75xn	201	4	supported	support	VBN
cord-018089-m94q75xn	201	5	by	by	IN
cord-018089-m94q75xn	201	6	recent	recent	JJ
cord-018089-m94q75xn	201	7	work	work	NN
cord-018089-m94q75xn	201	8	demonstrating	demonstrate	VBG
cord-018089-m94q75xn	201	9	that	that	DT
cord-018089-m94q75xn	201	10	replacement	replacement	NN
cord-018089-m94q75xn	201	11	of	of	IN
cord-018089-m94q75xn	201	12	the	the	DT
cord-018089-m94q75xn	201	13	lysine	lysine	NN
cord-018089-m94q75xn	201	14	at	at	IN
cord-018089-m94q75xn	201	15	position	position	NN
cord-018089-m94q75xn	201	16	627	627	CD
cord-018089-m94q75xn	201	17	with	with	IN
cord-018089-m94q75xn	201	18	glutamic	glutamic	NN
cord-018089-m94q75xn	201	19	acid	acid	NN
cord-018089-m94q75xn	201	20	(	(	-LRB-
cord-018089-m94q75xn	201	21	avian	avian	JJ
cord-018089-m94q75xn	201	22	consensus	consensus	NN
cord-018089-m94q75xn	201	23	sequence	sequence	NN
cord-018089-m94q75xn	201	24	)	)	-RRB-
cord-018089-m94q75xn	201	25	abrogates	abrogate	VBZ
cord-018089-m94q75xn	201	26	aerosol	aerosol	NN
cord-018089-m94q75xn	201	27	transmission	transmission	NN
cord-018089-m94q75xn	201	28	of	of	IN
cord-018089-m94q75xn	201	29	a	a	DT
cord-018089-m94q75xn	201	30	1918	1918	CD
cord-018089-m94q75xn	201	31	influenza	influenza	NN
cord-018089-m94q75xn	201	32	A	a	DT
cord-018089-m94q75xn	201	33	virus	virus	NN
cord-018089-m94q75xn	201	34	[	[	-LRB-
cord-018089-m94q75xn	201	35	30	30	CD
cord-018089-m94q75xn	201	36	]	]	-RRB-
cord-018089-m94q75xn	201	37	.	.	.
cord-018089-m94q75xn	202	1	Currently	currently	RB
cord-018089-m94q75xn	202	2	circulating	circulate	VBG
cord-018089-m94q75xn	202	3	strains	strain	NNS
cord-018089-m94q75xn	202	4	of	of	IN
cord-018089-m94q75xn	202	5	pandemic	pandemic	JJ
cord-018089-m94q75xn	202	6	H1N1	H1N1	NNP
cord-018089-m94q75xn	202	7	influenza	influenza	NN
cord-018089-m94q75xn	202	8	virus	virus	NN
cord-018089-m94q75xn	202	9	have	have	VBP
cord-018089-m94q75xn	202	10	a	a	DT
cord-018089-m94q75xn	202	11	glutamine	glutamine	NN
cord-018089-m94q75xn	202	12	in	in	IN
cord-018089-m94q75xn	202	13	PB2	PB2	NNP
cord-018089-m94q75xn	202	14	at	at	IN
cord-018089-m94q75xn	202	15	position	position	NN
cord-018089-m94q75xn	202	16	627	627	CD
cord-018089-m94q75xn	202	17	.	.	.
cord-018089-m94q75xn	203	1	This	this	DT
cord-018089-m94q75xn	203	2	may	may	MD
cord-018089-m94q75xn	203	3	account	account	VB
cord-018089-m94q75xn	203	4	for	for	IN
cord-018089-m94q75xn	203	5	reduced	reduce	VBN
cord-018089-m94q75xn	203	6	efficiency	efficiency	NN
cord-018089-m94q75xn	203	7	of	of	IN
cord-018089-m94q75xn	203	8	aerosol	aerosol	NN
cord-018089-m94q75xn	203	9	transmission	transmission	NN
cord-018089-m94q75xn	203	10	of	of	IN
cord-018089-m94q75xn	203	11	this	this	DT
cord-018089-m94q75xn	203	12	virus	virus	NN
cord-018089-m94q75xn	203	13	in	in	IN
cord-018089-m94q75xn	203	14	ferrets	ferret	NNS
cord-018089-m94q75xn	203	15	,	,	,
cord-018089-m94q75xn	203	16	compared	compare	VBN
cord-018089-m94q75xn	203	17	with	with	IN
cord-018089-m94q75xn	203	18	a	a	DT
cord-018089-m94q75xn	203	19	seasonal	seasonal	JJ
cord-018089-m94q75xn	203	20	H1N1	H1N1	NNP
cord-018089-m94q75xn	203	21	virus	virus	NN
cord-018089-m94q75xn	203	22	[	[	-LRB-
cord-018089-m94q75xn	203	23	29	29	CD
cord-018089-m94q75xn	203	24	]	]	-RRB-
cord-018089-m94q75xn	203	25	.	.	.
cord-018089-m94q75xn	204	1	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	204	2	is	be	VBZ
cord-018089-m94q75xn	204	3	the	the	DT
cord-018089-m94q75xn	204	4	gene	gene	NN
cord-018089-m94q75xn	204	5	product	product	NN
cord-018089-m94q75xn	204	6	arising	arise	VBG
cord-018089-m94q75xn	204	7	from	from	IN
cord-018089-m94q75xn	204	8	a	a	DT
cord-018089-m94q75xn	204	9	second	second	JJ
cord-018089-m94q75xn	204	10	reading	reading	NN
cord-018089-m94q75xn	204	11	frame	frame	NN
cord-018089-m94q75xn	204	12	of	of	IN
cord-018089-m94q75xn	204	13	the	the	DT
cord-018089-m94q75xn	204	14	PB1	PB1	NNP
cord-018089-m94q75xn	204	15	gene	gene	NN
cord-018089-m94q75xn	204	16	and	and	CC
cord-018089-m94q75xn	204	17	has	have	VBZ
cord-018089-m94q75xn	204	18	been	be	VBN
cord-018089-m94q75xn	204	19	implicated	implicate	VBN
cord-018089-m94q75xn	204	20	in	in	IN
cord-018089-m94q75xn	204	21	immune	immune	JJ
cord-018089-m94q75xn	204	22	cell	cell	NN
cord-018089-m94q75xn	204	23	apoptosis	apoptosis	NN
cord-018089-m94q75xn	204	24	through	through	IN
cord-018089-m94q75xn	204	25	the	the	DT
cord-018089-m94q75xn	204	26	VDAC1	vdac1	NN
cord-018089-m94q75xn	204	27	and	and	CC
cord-018089-m94q75xn	204	28	ANT3	ANT3	NNP
cord-018089-m94q75xn	204	29	mitochondrial	mitochondrial	JJ
cord-018089-m94q75xn	204	30	pathways	pathway	NNS
cord-018089-m94q75xn	204	31	[	[	-LRB-
cord-018089-m94q75xn	204	32	138	138	CD
cord-018089-m94q75xn	204	33	]	]	-RRB-
cord-018089-m94q75xn	204	34	.	.	.
cord-018089-m94q75xn	205	1	Knockout	knockout	NN
cord-018089-m94q75xn	205	2	of	of	IN
cord-018089-m94q75xn	205	3	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	205	4	did	do	VBD
cord-018089-m94q75xn	205	5	not	not	RB
cord-018089-m94q75xn	205	6	alter	alter	VB
cord-018089-m94q75xn	205	7	viral	viral	JJ
cord-018089-m94q75xn	205	8	replication	replication	NN
cord-018089-m94q75xn	205	9	,	,	,
cord-018089-m94q75xn	205	10	but	but	CC
cord-018089-m94q75xn	205	11	enhanced	enhanced	JJ
cord-018089-m94q75xn	205	12	clearance	clearance	NN
cord-018089-m94q75xn	205	13	of	of	IN
cord-018089-m94q75xn	205	14	the	the	DT
cord-018089-m94q75xn	205	15	virus	virus	NN
cord-018089-m94q75xn	205	16	and	and	CC
cord-018089-m94q75xn	205	17	reduced	reduce	VBN
cord-018089-m94q75xn	205	18	lethality	lethality	NN
cord-018089-m94q75xn	205	19	in	in	IN
cord-018089-m94q75xn	205	20	mice	mouse	NNS
cord-018089-m94q75xn	205	21	was	be	VBD
cord-018089-m94q75xn	205	22	demonstrated	demonstrate	VBN
cord-018089-m94q75xn	205	23	,	,	,
cord-018089-m94q75xn	205	24	suggesting	suggest	VBG
cord-018089-m94q75xn	205	25	that	that	IN
cord-018089-m94q75xn	205	26	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	205	27	may	may	MD
cord-018089-m94q75xn	205	28	play	play	VB
cord-018089-m94q75xn	205	29	a	a	DT
cord-018089-m94q75xn	205	30	role	role	NN
cord-018089-m94q75xn	205	31	in	in	IN
cord-018089-m94q75xn	205	32	viral	viral	JJ
cord-018089-m94q75xn	205	33	pathogenesis	pathogenesis	NN
cord-018089-m94q75xn	205	34	[	[	-LRB-
cord-018089-m94q75xn	205	35	139	139	CD
cord-018089-m94q75xn	205	36	]	]	-RRB-
cord-018089-m94q75xn	205	37	.	.	.
cord-018089-m94q75xn	206	1	Enhanced	enhanced	JJ
cord-018089-m94q75xn	206	2	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	206	3	was	be	VBD
cord-018089-m94q75xn	206	4	observed	observe	VBN
cord-018089-m94q75xn	206	5	in	in	IN
cord-018089-m94q75xn	206	6	mice	mouse	NNS
cord-018089-m94q75xn	206	7	infected	infect	VBN
cord-018089-m94q75xn	206	8	with	with	IN
cord-018089-m94q75xn	206	9	recombinant	recombinant	JJ
cord-018089-m94q75xn	206	10	influenza	influenza	NN
cord-018089-m94q75xn	206	11	virus	virus	NN
cord-018089-m94q75xn	206	12	containing	contain	VBG
cord-018089-m94q75xn	206	13	the	the	DT
cord-018089-m94q75xn	206	14	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	206	15	gene	gene	NN
cord-018089-m94q75xn	206	16	from	from	IN
cord-018089-m94q75xn	206	17	a	a	DT
cord-018089-m94q75xn	206	18	highly	highly	RB
cord-018089-m94q75xn	206	19	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	206	20	H5N1	H5N1	NNP
cord-018089-m94q75xn	206	21	virus	virus	NN
cord-018089-m94q75xn	206	22	isolated	isolate	VBN
cord-018089-m94q75xn	206	23	from	from	IN
cord-018089-m94q75xn	206	24	a	a	DT
cord-018089-m94q75xn	206	25	fatal	fatal	JJ
cord-018089-m94q75xn	206	26	human	human	JJ
cord-018089-m94q75xn	206	27	case	case	NN
cord-018089-m94q75xn	206	28	in	in	IN
cord-018089-m94q75xn	206	29	Hong	Hong	NNP
cord-018089-m94q75xn	206	30	Kong	Kong	NNP
cord-018089-m94q75xn	206	31	in	in	IN
cord-018089-m94q75xn	206	32	1997	1997	CD
cord-018089-m94q75xn	206	33	[	[	-LRB-
cord-018089-m94q75xn	206	34	139	139	CD
cord-018089-m94q75xn	206	35	]	]	-RRB-
cord-018089-m94q75xn	206	36	.	.	.
cord-018089-m94q75xn	207	1	Currently	currently	RB
cord-018089-m94q75xn	207	2	circulating	circulate	VBG
cord-018089-m94q75xn	207	3	strains	strain	NNS
cord-018089-m94q75xn	207	4	of	of	IN
cord-018089-m94q75xn	207	5	the	the	DT
cord-018089-m94q75xn	207	6	pandemic	pandemic	NN
cord-018089-m94q75xn	207	7	influenza	influenza	NN
cord-018089-m94q75xn	207	8	A	a	DT
cord-018089-m94q75xn	207	9	H1N1	H1N1	NNP
cord-018089-m94q75xn	207	10	2009	2009	CD
cord-018089-m94q75xn	207	11	virus	virus	NN
cord-018089-m94q75xn	207	12	do	do	VBP
cord-018089-m94q75xn	207	13	not	not	RB
cord-018089-m94q75xn	207	14	express	express	VB
cord-018089-m94q75xn	207	15	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	207	16	.	.	.
cord-018089-m94q75xn	208	1	Evasion	evasion	NN
cord-018089-m94q75xn	208	2	of	of	IN
cord-018089-m94q75xn	208	3	the	the	DT
cord-018089-m94q75xn	208	4	host	host	NN
cord-018089-m94q75xn	208	5	immune	immune	JJ
cord-018089-m94q75xn	208	6	response	response	NN
cord-018089-m94q75xn	208	7	is	be	VBZ
cord-018089-m94q75xn	208	8	a	a	DT
cord-018089-m94q75xn	208	9	key	key	JJ
cord-018089-m94q75xn	208	10	virulence	virulence	NN
cord-018089-m94q75xn	208	11	determinant	determinant	NN
cord-018089-m94q75xn	208	12	,	,	,
cord-018089-m94q75xn	208	13	permitting	permit	VBG
cord-018089-m94q75xn	208	14	viruses	virus	NNS
cord-018089-m94q75xn	208	15	to	to	TO
cord-018089-m94q75xn	208	16	establish	establish	VB
cord-018089-m94q75xn	208	17	sustainable	sustainable	JJ
cord-018089-m94q75xn	208	18	infection	infection	NN
cord-018089-m94q75xn	208	19	.	.	.
cord-018089-m94q75xn	209	1	The	the	DT
cord-018089-m94q75xn	209	2	innate	innate	JJ
cord-018089-m94q75xn	209	3	immune	immune	JJ
cord-018089-m94q75xn	209	4	system	system	NN
cord-018089-m94q75xn	209	5	is	be	VBZ
cord-018089-m94q75xn	209	6	the	the	DT
cord-018089-m94q75xn	209	7	first	first	JJ
cord-018089-m94q75xn	209	8	line	line	NN
cord-018089-m94q75xn	209	9	of	of	IN
cord-018089-m94q75xn	209	10	host	host	NN
cord-018089-m94q75xn	209	11	defense	defense	NN
cord-018089-m94q75xn	209	12	,	,	,
cord-018089-m94q75xn	209	13	and	and	CC
cord-018089-m94q75xn	209	14	the	the	DT
cord-018089-m94q75xn	209	15	influenza	influenza	NN
cord-018089-m94q75xn	209	16	virus	virus	NN
cord-018089-m94q75xn	209	17	possesses	possess	VBZ
cord-018089-m94q75xn	209	18	the	the	DT
cord-018089-m94q75xn	209	19	ability	ability	NN
cord-018089-m94q75xn	209	20	to	to	TO
cord-018089-m94q75xn	209	21	interfere	interfere	VB
cord-018089-m94q75xn	209	22	with	with	IN
cord-018089-m94q75xn	209	23	this	this	DT
cord-018089-m94q75xn	209	24	response	response	NN
cord-018089-m94q75xn	209	25	.	.	.
cord-018089-m94q75xn	210	1	Type	type	NN
cord-018089-m94q75xn	210	2	I	-PRON-	PRP
cord-018089-m94q75xn	210	3	interferons	interferon	NNS
cord-018089-m94q75xn	211	1	(	(	-LRB-
cord-018089-m94q75xn	211	2	IFN	IFN	NNP
cord-018089-m94q75xn	211	3	-	-	HYPH
cord-018089-m94q75xn	211	4	a	a	NNP
cord-018089-m94q75xn	211	5	/	/	SYM
cord-018089-m94q75xn	211	6	b	b	NN
cord-018089-m94q75xn	211	7	)	)	-RRB-
cord-018089-m94q75xn	211	8	are	be	VBP
cord-018089-m94q75xn	211	9	central	central	JJ
cord-018089-m94q75xn	211	10	to	to	IN
cord-018089-m94q75xn	211	11	establishing	establish	VBG
cord-018089-m94q75xn	211	12	an	an	DT
cord-018089-m94q75xn	211	13	antiviral	antiviral	JJ
cord-018089-m94q75xn	211	14	state	state	NN
cord-018089-m94q75xn	211	15	in	in	IN
cord-018089-m94q75xn	211	16	host	host	NN
cord-018089-m94q75xn	211	17	cells	cell	NNS
cord-018089-m94q75xn	211	18	.	.	.
cord-018089-m94q75xn	212	1	Interferon	interferon	NN
cord-018089-m94q75xn	212	2	antagonism	antagonism	NN
cord-018089-m94q75xn	212	3	has	have	VBZ
cord-018089-m94q75xn	212	4	been	be	VBN
cord-018089-m94q75xn	212	5	primarily	primarily	RB
cord-018089-m94q75xn	212	6	attributed	attribute	VBN
cord-018089-m94q75xn	212	7	to	to	IN
cord-018089-m94q75xn	212	8	the	the	DT
cord-018089-m94q75xn	212	9	NS1	ns1	NN
cord-018089-m94q75xn	212	10	protein	protein	NN
cord-018089-m94q75xn	212	11	of	of	IN
cord-018089-m94q75xn	212	12	influenza	influenza	NNP
cord-018089-m94q75xn	212	13	virus	virus	NN
cord-018089-m94q75xn	212	14	,	,	,
cord-018089-m94q75xn	212	15	which	which	WDT
cord-018089-m94q75xn	212	16	plays	play	VBZ
cord-018089-m94q75xn	212	17	a	a	DT
cord-018089-m94q75xn	212	18	multifunctional	multifunctional	JJ
cord-018089-m94q75xn	212	19	role	role	NN
cord-018089-m94q75xn	212	20	in	in	IN
cord-018089-m94q75xn	212	21	preventing	prevent	VBG
cord-018089-m94q75xn	212	22	the	the	DT
cord-018089-m94q75xn	212	23	activation	activation	NN
cord-018089-m94q75xn	212	24	of	of	IN
cord-018089-m94q75xn	212	25	IFN	IFN	NNP
cord-018089-m94q75xn	212	26	transcription	transcription	NN
cord-018089-m94q75xn	212	27	factors	factor	NNS
cord-018089-m94q75xn	212	28	(	(	-LRB-
cord-018089-m94q75xn	212	29	for	for	IN
cord-018089-m94q75xn	212	30	review	review	NN
cord-018089-m94q75xn	212	31	,	,	,
cord-018089-m94q75xn	212	32	see	see	VB
cord-018089-m94q75xn	212	33	[	[	-LRB-
cord-018089-m94q75xn	212	34	140	140	CD
cord-018089-m94q75xn	212	35	,	,	,
cord-018089-m94q75xn	212	36	141	141	CD
cord-018089-m94q75xn	212	37	]	]	-RRB-
cord-018089-m94q75xn	212	38	)	)	-RRB-
cord-018089-m94q75xn	212	39	.	.	.
cord-018089-m94q75xn	213	1	The	the	DT
cord-018089-m94q75xn	213	2	effect	effect	NN
cord-018089-m94q75xn	213	3	of	of	IN
cord-018089-m94q75xn	213	4	avian	avian	JJ
cord-018089-m94q75xn	213	5	influenza	influenza	NN
cord-018089-m94q75xn	213	6	virus	virus	NN
cord-018089-m94q75xn	213	7	NS1	NS1	VBZ
cord-018089-m94q75xn	213	8	on	on	IN
cord-018089-m94q75xn	213	9	IFN	IFN	NNP
cord-018089-m94q75xn	213	10	production	production	NN
cord-018089-m94q75xn	213	11	has	have	VBZ
cord-018089-m94q75xn	213	12	also	also	RB
cord-018089-m94q75xn	213	13	been	be	VBN
cord-018089-m94q75xn	213	14	explored	explore	VBN
cord-018089-m94q75xn	213	15	.	.	.
cord-018089-m94q75xn	214	1	A	a	DT
cord-018089-m94q75xn	214	2	/	/	SYM
cord-018089-m94q75xn	214	3	goose	goose	NN
cord-018089-m94q75xn	214	4	/	/	SYM
cord-018089-m94q75xn	214	5	Guangdong/1/96	guangdong/1/96	VBP
cord-018089-m94q75xn	214	6	virus	virus	NN
cord-018089-m94q75xn	214	7	with	with	IN
cord-018089-m94q75xn	214	8	an	an	DT
cord-018089-m94q75xn	214	9	NS1	ns1	NN
cord-018089-m94q75xn	214	10	that	that	WDT
cord-018089-m94q75xn	214	11	differs	differ	VBZ
cord-018089-m94q75xn	214	12	by	by	IN
cord-018089-m94q75xn	214	13	one	one	CD
cord-018089-m94q75xn	214	14	amino	amino	NN
cord-018089-m94q75xn	214	15	acid	acid	NN
cord-018089-m94q75xn	214	16	from	from	IN
cord-018089-m94q75xn	214	17	A	a	NN
cord-018089-m94q75xn	214	18	/	/	SYM
cord-018089-m94q75xn	214	19	goose	goose	NN
cord-018089-m94q75xn	214	20	/	/	SYM
cord-018089-m94q75xn	214	21	Guangdong/2/96	Guangdong/2/96	VBZ
cord-018089-m94q75xn	214	22	at	at	IN
cord-018089-m94q75xn	214	23	position	position	NN
cord-018089-m94q75xn	214	24	149	149	CD
cord-018089-m94q75xn	214	25	is	be	VBZ
cord-018089-m94q75xn	214	26	lethal	lethal	JJ
cord-018089-m94q75xn	214	27	in	in	IN
cord-018089-m94q75xn	214	28	chickens	chicken	NNS
cord-018089-m94q75xn	214	29	and	and	CC
cord-018089-m94q75xn	214	30	antagonizes	antagonize	VBZ
cord-018089-m94q75xn	214	31	IFNa	IFNa	NNS
cord-018089-m94q75xn	214	32	/	/	SYM
cord-018089-m94q75xn	214	33	b	b	NN
cord-018089-m94q75xn	214	34	[	[	-LRB-
cord-018089-m94q75xn	214	35	142	142	CD
cord-018089-m94q75xn	214	36	]	]	-RRB-
cord-018089-m94q75xn	214	37	.	.	.
cord-018089-m94q75xn	215	1	In	in	IN
cord-018089-m94q75xn	215	2	addition	addition	NN
cord-018089-m94q75xn	215	3	,	,	,
cord-018089-m94q75xn	215	4	the	the	DT
cord-018089-m94q75xn	215	5	C	c	NN
cord-018089-m94q75xn	215	6	-	-	HYPH
cord-018089-m94q75xn	215	7	terminus	terminus	NN
cord-018089-m94q75xn	215	8	of	of	IN
cord-018089-m94q75xn	215	9	the	the	DT
cord-018089-m94q75xn	215	10	NS1	NS1	NNP
cord-018089-m94q75xn	215	11	protein	protein	NN
cord-018089-m94q75xn	215	12	contains	contain	VBZ
cord-018089-m94q75xn	215	13	a	a	DT
cord-018089-m94q75xn	215	14	PDZ	PDZ	NNP
cord-018089-m94q75xn	215	15	ligand	ligand	NN
cord-018089-m94q75xn	215	16	domain	domain	NN
cord-018089-m94q75xn	215	17	,	,	,
cord-018089-m94q75xn	215	18	capable	capable	JJ
cord-018089-m94q75xn	215	19	of	of	IN
cord-018089-m94q75xn	215	20	binding	bind	VBG
cord-018089-m94q75xn	215	21	PDZ	PDZ	NNP
cord-018089-m94q75xn	215	22	protein	protein	NN
cord-018089-m94q75xn	215	23	interaction	interaction	NN
cord-018089-m94q75xn	215	24	domains	domain	NNS
cord-018089-m94q75xn	215	25	of	of	IN
cord-018089-m94q75xn	215	26	host	host	NN
cord-018089-m94q75xn	215	27	proteins	protein	NNS
cord-018089-m94q75xn	215	28	,	,	,
cord-018089-m94q75xn	215	29	thus	thus	RB
cord-018089-m94q75xn	215	30	potentially	potentially	RB
cord-018089-m94q75xn	215	31	disrupting	disrupt	VBG
cord-018089-m94q75xn	215	32	host	host	NN
cord-018089-m94q75xn	215	33	cellular	cellular	JJ
cord-018089-m94q75xn	215	34	pathways	pathway	NNS
cord-018089-m94q75xn	215	35	.	.	.
cord-018089-m94q75xn	216	1	Viruses	virus	NNS
cord-018089-m94q75xn	216	2	causing	cause	VBG
cord-018089-m94q75xn	216	3	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	216	4	infection	infection	NN
cord-018089-m94q75xn	216	5	in	in	IN
cord-018089-m94q75xn	216	6	humans	human	NNS
cord-018089-m94q75xn	216	7	between	between	IN
cord-018089-m94q75xn	216	8	1997	1997	CD
cord-018089-m94q75xn	216	9	and	and	CC
cord-018089-m94q75xn	216	10	2003	2003	CD
cord-018089-m94q75xn	216	11	contained	contain	VBD
cord-018089-m94q75xn	216	12	avian	avian	JJ
cord-018089-m94q75xn	216	13	motifs	motif	NNS
cord-018089-m94q75xn	216	14	at	at	IN
cord-018089-m94q75xn	216	15	the	the	DT
cord-018089-m94q75xn	216	16	NS1	ns1	NN
cord-018089-m94q75xn	216	17	PDZ	PDZ	NNP
cord-018089-m94q75xn	216	18	ligand	ligand	NN
cord-018089-m94q75xn	216	19	-	-	HYPH
cord-018089-m94q75xn	216	20	binding	bind	VBG
cord-018089-m94q75xn	216	21	site	site	NN
cord-018089-m94q75xn	216	22	.	.	.
cord-018089-m94q75xn	217	1	These	these	DT
cord-018089-m94q75xn	217	2	and	and	CC
cord-018089-m94q75xn	217	3	the	the	DT
cord-018089-m94q75xn	217	4	motif	motif	NN
cord-018089-m94q75xn	217	5	found	find	VBN
cord-018089-m94q75xn	217	6	in	in	IN
cord-018089-m94q75xn	217	7	the	the	DT
cord-018089-m94q75xn	217	8	1918	1918	CD
cord-018089-m94q75xn	217	9	influenza	influenza	NN
cord-018089-m94q75xn	217	10	virus	virus	NN
cord-018089-m94q75xn	217	11	NS1	ns1	CD
cord-018089-m94q75xn	217	12	had	have	VBD
cord-018089-m94q75xn	217	13	stronger	strong	JJR
cord-018089-m94q75xn	217	14	binding	bind	VBG
cord-018089-m94q75xn	217	15	affinities	affinity	NNS
cord-018089-m94q75xn	217	16	to	to	IN
cord-018089-m94q75xn	217	17	PDZ	PDZ	NNP
cord-018089-m94q75xn	217	18	domains	domain	NNS
cord-018089-m94q75xn	217	19	of	of	IN
cord-018089-m94q75xn	217	20	human	human	JJ
cord-018089-m94q75xn	217	21	cellular	cellular	JJ
cord-018089-m94q75xn	217	22	proteins	protein	NNS
cord-018089-m94q75xn	217	23	compared	compare	VBN
cord-018089-m94q75xn	217	24	with	with	IN
cord-018089-m94q75xn	217	25	low	low	JJ
cord-018089-m94q75xn	217	26	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	217	27	influenza	influenza	NN
cord-018089-m94q75xn	217	28	viruses	virus	NNS
cord-018089-m94q75xn	217	29	[	[	-LRB-
cord-018089-m94q75xn	217	30	143	143	CD
cord-018089-m94q75xn	217	31	]	]	-RRB-
cord-018089-m94q75xn	217	32	.	.	.
cord-018089-m94q75xn	218	1	Neurovirulence	Neurovirulence	NNP
cord-018089-m94q75xn	218	2	has	have	VBZ
cord-018089-m94q75xn	218	3	been	be	VBN
cord-018089-m94q75xn	218	4	associated	associate	VBN
cord-018089-m94q75xn	218	5	with	with	IN
cord-018089-m94q75xn	218	6	glycosylation	glycosylation	NN
cord-018089-m94q75xn	218	7	of	of	IN
cord-018089-m94q75xn	218	8	the	the	DT
cord-018089-m94q75xn	218	9	NA	NA	NNP
cord-018089-m94q75xn	218	10	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	218	11	[	[	-LRB-
cord-018089-m94q75xn	218	12	144	144	CD
cord-018089-m94q75xn	218	13	]	]	-RRB-
cord-018089-m94q75xn	218	14	.	.	.
cord-018089-m94q75xn	219	1	The	the	DT
cord-018089-m94q75xn	219	2	HA	HA	NNP
cord-018089-m94q75xn	219	3	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	219	4	has	have	VBZ
cord-018089-m94q75xn	219	5	also	also	RB
cord-018089-m94q75xn	219	6	been	be	VBN
cord-018089-m94q75xn	219	7	associated	associate	VBN
cord-018089-m94q75xn	219	8	with	with	IN
cord-018089-m94q75xn	219	9	virulence	virulence	NN
cord-018089-m94q75xn	219	10	.	.	.
cord-018089-m94q75xn	220	1	Although	although	IN
cord-018089-m94q75xn	220	2	cleavability	cleavability	NN
cord-018089-m94q75xn	220	3	of	of	IN
cord-018089-m94q75xn	220	4	the	the	DT
cord-018089-m94q75xn	220	5	HA	HA	NNP
cord-018089-m94q75xn	220	6	gene	gene	NN
cord-018089-m94q75xn	220	7	has	have	VBZ
cord-018089-m94q75xn	220	8	been	be	VBN
cord-018089-m94q75xn	220	9	primarily	primarily	RB
cord-018089-m94q75xn	220	10	implicated	implicate	VBN
cord-018089-m94q75xn	220	11	in	in	IN
cord-018089-m94q75xn	220	12	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	220	13	in	in	IN
cord-018089-m94q75xn	220	14	chickens	chicken	NNS
cord-018089-m94q75xn	220	15	,	,	,
cord-018089-m94q75xn	220	16	lethality	lethality	NN
cord-018089-m94q75xn	220	17	has	have	VBZ
cord-018089-m94q75xn	220	18	also	also	RB
cord-018089-m94q75xn	220	19	been	be	VBN
cord-018089-m94q75xn	220	20	demonstrated	demonstrate	VBN
cord-018089-m94q75xn	220	21	in	in	IN
cord-018089-m94q75xn	220	22	mice	mouse	NNS
cord-018089-m94q75xn	220	23	.	.	.
cord-018089-m94q75xn	221	1	Basic	basic	JJ
cord-018089-m94q75xn	221	2	amino	amino	NN
cord-018089-m94q75xn	221	3	acids	acid	NNS
cord-018089-m94q75xn	221	4	at	at	IN
cord-018089-m94q75xn	221	5	the	the	DT
cord-018089-m94q75xn	221	6	HA	HA	NNP
cord-018089-m94q75xn	221	7	cleavage	cleavage	NN
cord-018089-m94q75xn	221	8	site	site	NN
cord-018089-m94q75xn	221	9	are	be	VBP
cord-018089-m94q75xn	221	10	determinants	determinant	NNS
cord-018089-m94q75xn	221	11	for	for	IN
cord-018089-m94q75xn	221	12	HA	HA	NNP
cord-018089-m94q75xn	221	13	cleavage	cleavage	NN
cord-018089-m94q75xn	221	14	and	and	CC
cord-018089-m94q75xn	221	15	HA2	HA2	NNP
cord-018089-m94q75xn	221	16	fusion	fusion	NN
cord-018089-m94q75xn	221	17	activity	activity	NN
cord-018089-m94q75xn	221	18	[	[	-LRB-
cord-018089-m94q75xn	221	19	145	145	CD
cord-018089-m94q75xn	221	20	]	]	-RRB-
cord-018089-m94q75xn	221	21	.	.	.
cord-018089-m94q75xn	222	1	Enhanced	enhanced	JJ
cord-018089-m94q75xn	222	2	cleavage	cleavage	NN
cord-018089-m94q75xn	222	3	of	of	IN
cord-018089-m94q75xn	222	4	the	the	DT
cord-018089-m94q75xn	222	5	HA	HA	NNP
cord-018089-m94q75xn	222	6	by	by	IN
cord-018089-m94q75xn	222	7	ubiquitous	ubiquitous	JJ
cord-018089-m94q75xn	222	8	host	host	NN
cord-018089-m94q75xn	222	9	proteases	protease	NNS
cord-018089-m94q75xn	222	10	is	be	VBZ
cord-018089-m94q75xn	222	11	made	make	VBN
cord-018089-m94q75xn	222	12	possible	possible	JJ
cord-018089-m94q75xn	222	13	by	by	IN
cord-018089-m94q75xn	222	14	the	the	DT
cord-018089-m94q75xn	222	15	presence	presence	NN
cord-018089-m94q75xn	222	16	of	of	IN
cord-018089-m94q75xn	222	17	a	a	DT
cord-018089-m94q75xn	222	18	polybasic	polybasic	JJ
cord-018089-m94q75xn	222	19	cleavage	cleavage	NN
cord-018089-m94q75xn	222	20	site	site	NN
cord-018089-m94q75xn	222	21	,	,	,
cord-018089-m94q75xn	222	22	contributing	contribute	VBG
cord-018089-m94q75xn	222	23	to	to	IN
cord-018089-m94q75xn	222	24	the	the	DT
cord-018089-m94q75xn	222	25	virulence	virulence	NN
cord-018089-m94q75xn	222	26	of	of	IN
cord-018089-m94q75xn	222	27	highly	highly	RB
cord-018089-m94q75xn	222	28	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	222	29	avian	avian	JJ
cord-018089-m94q75xn	222	30	influenza	influenza	NN
cord-018089-m94q75xn	222	31	viruses	virus	NNS
cord-018089-m94q75xn	222	32	[	[	-LRB-
cord-018089-m94q75xn	222	33	146	146	CD
cord-018089-m94q75xn	222	34	,	,	,
cord-018089-m94q75xn	222	35	147	147	CD
cord-018089-m94q75xn	222	36	]	]	-RRB-
cord-018089-m94q75xn	222	37	.	.	.
cord-018089-m94q75xn	223	1	Replacement	replacement	NN
cord-018089-m94q75xn	223	2	of	of	IN
cord-018089-m94q75xn	223	3	the	the	DT
cord-018089-m94q75xn	223	4	polybasic	polybasic	JJ
cord-018089-m94q75xn	223	5	cleavage	cleavage	NN
cord-018089-m94q75xn	223	6	site	site	NN
cord-018089-m94q75xn	223	7	in	in	IN
cord-018089-m94q75xn	223	8	a	a	DT
cord-018089-m94q75xn	223	9	high	high	JJ
cord-018089-m94q75xn	223	10	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	223	11	H5N1	H5N1	NNP
cord-018089-m94q75xn	223	12	virus	virus	NN
cord-018089-m94q75xn	223	13	from	from	IN
cord-018089-m94q75xn	223	14	Hong	Hong	NNP
cord-018089-m94q75xn	223	15	Kong	Kong	NNP
cord-018089-m94q75xn	223	16	(	(	-LRB-
cord-018089-m94q75xn	223	17	HK483	HK483	NNP
cord-018089-m94q75xn	223	18	)	)	-RRB-
cord-018089-m94q75xn	223	19	with	with	IN
cord-018089-m94q75xn	223	20	an	an	DT
cord-018089-m94q75xn	223	21	amino	amino	NN
cord-018089-m94q75xn	223	22	acid	acid	NN
cord-018089-m94q75xn	223	23	sequence	sequence	NN
cord-018089-m94q75xn	223	24	typical	typical	JJ
cord-018089-m94q75xn	223	25	of	of	IN
cord-018089-m94q75xn	223	26	low	low	JJ
cord-018089-m94q75xn	223	27	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	223	28	viruses	virus	NNS
cord-018089-m94q75xn	223	29	resulted	result	VBD
cord-018089-m94q75xn	223	30	in	in	IN
cord-018089-m94q75xn	223	31	attenuation	attenuation	NN
cord-018089-m94q75xn	223	32	[	[	-LRB-
cord-018089-m94q75xn	223	33	133	133	CD
cord-018089-m94q75xn	223	34	]	]	-RRB-
cord-018089-m94q75xn	223	35	.	.	.
cord-018089-m94q75xn	224	1	Pandemic	pandemic	NN
cord-018089-m94q75xn	224	2	influenza	influenza	NN
cord-018089-m94q75xn	225	1	A	a	DT
cord-018089-m94q75xn	225	2	H1N1	H1N1	NNP
cord-018089-m94q75xn	225	3	2009	2009	CD
cord-018089-m94q75xn	225	4	virus	virus	NN
cord-018089-m94q75xn	225	5	strains	strain	NNS
cord-018089-m94q75xn	225	6	do	do	VBP
cord-018089-m94q75xn	225	7	not	not	RB
cord-018089-m94q75xn	225	8	appear	appear	VB
cord-018089-m94q75xn	225	9	to	to	TO
cord-018089-m94q75xn	225	10	have	have	VB
cord-018089-m94q75xn	225	11	the	the	DT
cord-018089-m94q75xn	225	12	polybasic	polybasic	JJ
cord-018089-m94q75xn	225	13	cleavage	cleavage	NN
cord-018089-m94q75xn	225	14	site	site	NN
cord-018089-m94q75xn	225	15	.	.	.
cord-018089-m94q75xn	226	1	Virulence	virulence	NN
cord-018089-m94q75xn	226	2	determinants	determinant	NNS
cord-018089-m94q75xn	226	3	for	for	IN
cord-018089-m94q75xn	226	4	the	the	DT
cord-018089-m94q75xn	226	5	pandemic	pandemic	NN
cord-018089-m94q75xn	226	6	2009	2009	CD
cord-018089-m94q75xn	226	7	H1N1	H1N1	NNP
cord-018089-m94q75xn	226	8	virus	virus	NN
cord-018089-m94q75xn	226	9	are	be	VBP
cord-018089-m94q75xn	226	10	currently	currently	RB
cord-018089-m94q75xn	226	11	investigation	investigation	NN
cord-018089-m94q75xn	226	12	.	.	.
cord-018089-m94q75xn	227	1	Data	datum	NNS
cord-018089-m94q75xn	227	2	obtained	obtain	VBN
cord-018089-m94q75xn	227	3	from	from	IN
cord-018089-m94q75xn	227	4	mammalian	mammalian	JJ
cord-018089-m94q75xn	227	5	models	model	NNS
cord-018089-m94q75xn	227	6	early	early	RB
cord-018089-m94q75xn	227	7	in	in	IN
cord-018089-m94q75xn	227	8	the	the	DT
cord-018089-m94q75xn	227	9	course	course	NN
cord-018089-m94q75xn	227	10	of	of	IN
cord-018089-m94q75xn	227	11	the	the	DT
cord-018089-m94q75xn	227	12	spread	spread	NN
cord-018089-m94q75xn	227	13	of	of	IN
cord-018089-m94q75xn	227	14	this	this	DT
cord-018089-m94q75xn	227	15	virus	virus	NN
cord-018089-m94q75xn	227	16	indicate	indicate	VBP
cord-018089-m94q75xn	227	17	that	that	IN
cord-018089-m94q75xn	227	18	compared	compare	VBN
cord-018089-m94q75xn	227	19	with	with	IN
cord-018089-m94q75xn	227	20	a	a	DT
cord-018089-m94q75xn	227	21	seasonal	seasonal	JJ
cord-018089-m94q75xn	227	22	H1N1	H1N1	NNP
cord-018089-m94q75xn	227	23	influenza	influenza	NN
cord-018089-m94q75xn	227	24	virus	virus	NN
cord-018089-m94q75xn	227	25	,	,	,
cord-018089-m94q75xn	227	26	strains	strain	NNS
cord-018089-m94q75xn	227	27	of	of	IN
cord-018089-m94q75xn	227	28	the	the	DT
cord-018089-m94q75xn	227	29	pandemic	pandemic	NN
cord-018089-m94q75xn	227	30	virus	virus	NN
cord-018089-m94q75xn	227	31	replicate	replicate	VBP
cord-018089-m94q75xn	227	32	more	more	RBR
cord-018089-m94q75xn	227	33	efficiently	efficiently	RB
cord-018089-m94q75xn	227	34	in	in	IN
cord-018089-m94q75xn	227	35	the	the	DT
cord-018089-m94q75xn	227	36	lower	low	JJR
cord-018089-m94q75xn	227	37	respiratory	respiratory	JJ
cord-018089-m94q75xn	227	38	tract	tract	NN
cord-018089-m94q75xn	227	39	,	,	,
cord-018089-m94q75xn	227	40	and	and	CC
cord-018089-m94q75xn	227	41	are	be	VBP
cord-018089-m94q75xn	227	42	stronger	strong	JJR
cord-018089-m94q75xn	227	43	inducers	inducer	NNS
cord-018089-m94q75xn	227	44	of	of	IN
cord-018089-m94q75xn	227	45	proinflammatory	proinflammatory	JJ
cord-018089-m94q75xn	227	46	mediators	mediator	NNS
cord-018089-m94q75xn	227	47	,	,	,
cord-018089-m94q75xn	227	48	and	and	CC
cord-018089-m94q75xn	227	49	induce	induce	VB
cord-018089-m94q75xn	227	50	bronchopneumonia	bronchopneumonia	NN
cord-018089-m94q75xn	227	51	[	[	-LRB-
cord-018089-m94q75xn	227	52	148	148	CD
cord-018089-m94q75xn	227	53	]	]	-RRB-
cord-018089-m94q75xn	227	54	.	.	.
cord-018089-m94q75xn	228	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	228	2	A	A	NNP
cord-018089-m94q75xn	228	3	and	and	CC
cord-018089-m94q75xn	228	4	B	b	NN
cord-018089-m94q75xn	228	5	viruses	virus	NNS
cord-018089-m94q75xn	228	6	exhibit	exhibit	VBP
cord-018089-m94q75xn	228	7	marked	mark	VBN
cord-018089-m94q75xn	228	8	seasonality	seasonality	NN
cord-018089-m94q75xn	228	9	,	,	,
cord-018089-m94q75xn	228	10	and	and	CC
cord-018089-m94q75xn	228	11	this	this	DT
cord-018089-m94q75xn	228	12	pattern	pattern	NN
cord-018089-m94q75xn	228	13	dictates	dictate	VBZ
cord-018089-m94q75xn	228	14	the	the	DT
cord-018089-m94q75xn	228	15	annual	annual	JJ
cord-018089-m94q75xn	228	16	vaccination	vaccination	NN
cord-018089-m94q75xn	228	17	schedule	schedule	NN
cord-018089-m94q75xn	228	18	.	.	.
cord-018089-m94q75xn	229	1	Several	several	JJ
cord-018089-m94q75xn	229	2	theories	theory	NNS
cord-018089-m94q75xn	229	3	with	with	IN
cord-018089-m94q75xn	229	4	respect	respect	NN
cord-018089-m94q75xn	229	5	to	to	IN
cord-018089-m94q75xn	229	6	the	the	DT
cord-018089-m94q75xn	229	7	mechanism(s	mechanism(s	NNP
cord-018089-m94q75xn	229	8	)	)	-RRB-
cord-018089-m94q75xn	229	9	responsible	responsible	JJ
cord-018089-m94q75xn	229	10	for	for	IN
cord-018089-m94q75xn	229	11	this	this	DT
cord-018089-m94q75xn	229	12	seasonal	seasonal	JJ
cord-018089-m94q75xn	229	13	pattern	pattern	NN
cord-018089-m94q75xn	229	14	have	have	VBP
cord-018089-m94q75xn	229	15	been	be	VBN
cord-018089-m94q75xn	229	16	proposed	propose	VBN
cord-018089-m94q75xn	229	17	(	(	-LRB-
cord-018089-m94q75xn	229	18	for	for	IN
cord-018089-m94q75xn	229	19	review	review	NN
cord-018089-m94q75xn	229	20	,	,	,
cord-018089-m94q75xn	229	21	see	see	VB
cord-018089-m94q75xn	229	22	[	[	-LRB-
cord-018089-m94q75xn	229	23	149	149	CD
cord-018089-m94q75xn	229	24	]	]	-RRB-
cord-018089-m94q75xn	229	25	)	)	-RRB-
cord-018089-m94q75xn	229	26	.	.	.
cord-018089-m94q75xn	230	1	Year	year	NN
cord-018089-m94q75xn	230	2	-	-	HYPH
cord-018089-m94q75xn	230	3	round	round	JJ
cord-018089-m94q75xn	230	4	human	human	JJ
cord-018089-m94q75xn	230	5	influenza	influenza	NN
cord-018089-m94q75xn	230	6	virus	virus	NN
cord-018089-m94q75xn	230	7	activity	activity	NN
cord-018089-m94q75xn	230	8	in	in	IN
cord-018089-m94q75xn	230	9	equatorial	equatorial	JJ
cord-018089-m94q75xn	230	10	regions	region	NNS
cord-018089-m94q75xn	230	11	may	may	MD
cord-018089-m94q75xn	230	12	be	be	VB
cord-018089-m94q75xn	230	13	a	a	DT
cord-018089-m94q75xn	230	14	reservoir	reservoir	NN
cord-018089-m94q75xn	230	15	for	for	IN
cord-018089-m94q75xn	230	16	annual	annual	JJ
cord-018089-m94q75xn	230	17	outbreaks	outbreak	NNS
cord-018089-m94q75xn	230	18	in	in	IN
cord-018089-m94q75xn	230	19	the	the	DT
cord-018089-m94q75xn	230	20	northern	northern	JJ
cord-018089-m94q75xn	230	21	and	and	CC
cord-018089-m94q75xn	230	22	southern	southern	JJ
cord-018089-m94q75xn	230	23	hemispheres	hemisphere	NNS
cord-018089-m94q75xn	230	24	.	.	.
cord-018089-m94q75xn	231	1	As	as	IN
cord-018089-m94q75xn	231	2	research	research	NN
cord-018089-m94q75xn	231	3	progresses	progress	VBZ
cord-018089-m94q75xn	231	4	in	in	IN
cord-018089-m94q75xn	231	5	this	this	DT
cord-018089-m94q75xn	231	6	area	area	NN
cord-018089-m94q75xn	231	7	,	,	,
cord-018089-m94q75xn	231	8	factors	factor	NNS
cord-018089-m94q75xn	231	9	determining	determine	VBG
cord-018089-m94q75xn	231	10	seasonality	seasonality	NN
cord-018089-m94q75xn	231	11	may	may	MD
cord-018089-m94q75xn	231	12	be	be	VB
cord-018089-m94q75xn	231	13	exploited	exploit	VBN
cord-018089-m94q75xn	231	14	for	for	IN
cord-018089-m94q75xn	231	15	the	the	DT
cord-018089-m94q75xn	231	16	control	control	NN
cord-018089-m94q75xn	231	17	of	of	IN
cord-018089-m94q75xn	231	18	the	the	DT
cord-018089-m94q75xn	231	19	spread	spread	NN
cord-018089-m94q75xn	231	20	of	of	IN
cord-018089-m94q75xn	231	21	influenza	influenza	NN
cord-018089-m94q75xn	231	22	virus	virus	NN
cord-018089-m94q75xn	231	23	[	[	-LRB-
cord-018089-m94q75xn	231	24	150	150	CD
cord-018089-m94q75xn	231	25	]	]	-RRB-
cord-018089-m94q75xn	231	26	.	.	.
cord-018089-m94q75xn	232	1	Transmission	transmission	NN
cord-018089-m94q75xn	232	2	of	of	IN
cord-018089-m94q75xn	232	3	influenza	influenza	NN
cord-018089-m94q75xn	232	4	virus	virus	NN
cord-018089-m94q75xn	232	5	among	among	IN
cord-018089-m94q75xn	232	6	humans	human	NNS
cord-018089-m94q75xn	232	7	is	be	VBZ
cord-018089-m94q75xn	232	8	poorly	poorly	RB
cord-018089-m94q75xn	232	9	understood	understand	VBN
cord-018089-m94q75xn	232	10	and	and	CC
cord-018089-m94q75xn	232	11	the	the	DT
cord-018089-m94q75xn	232	12	mode(s	mode(s	NN
cord-018089-m94q75xn	232	13	)	)	-RRB-
cord-018089-m94q75xn	232	14	of	of	IN
cord-018089-m94q75xn	232	15	spread	spread	NN
cord-018089-m94q75xn	232	16	are	be	VBP
cord-018089-m94q75xn	232	17	currently	currently	RB
cord-018089-m94q75xn	232	18	under	under	IN
cord-018089-m94q75xn	232	19	debate	debate	NN
cord-018089-m94q75xn	232	20	[	[	-LRB-
cord-018089-m94q75xn	232	21	151	151	CD
cord-018089-m94q75xn	232	22	,	,	,
cord-018089-m94q75xn	232	23	152	152	CD
cord-018089-m94q75xn	232	24	]	]	-RRB-
cord-018089-m94q75xn	232	25	.	.	.
cord-018089-m94q75xn	233	1	It	-PRON-	PRP
cord-018089-m94q75xn	233	2	is	be	VBZ
cord-018089-m94q75xn	233	3	widely	widely	RB
cord-018089-m94q75xn	233	4	accepted	accept	VBN
cord-018089-m94q75xn	233	5	that	that	IN
cord-018089-m94q75xn	233	6	influenza	influenza	NN
cord-018089-m94q75xn	233	7	virus	virus	NN
cord-018089-m94q75xn	233	8	is	be	VBZ
cord-018089-m94q75xn	233	9	transmitted	transmit	VBN
cord-018089-m94q75xn	233	10	by	by	IN
cord-018089-m94q75xn	233	11	the	the	DT
cord-018089-m94q75xn	233	12	respiratory	respiratory	JJ
cord-018089-m94q75xn	233	13	route	route	NN
cord-018089-m94q75xn	233	14	in	in	IN
cord-018089-m94q75xn	233	15	humans	human	NNS
cord-018089-m94q75xn	233	16	,	,	,
cord-018089-m94q75xn	233	17	though	though	IN
cord-018089-m94q75xn	233	18	the	the	DT
cord-018089-m94q75xn	233	19	contribution	contribution	NN
cord-018089-m94q75xn	233	20	of	of	IN
cord-018089-m94q75xn	233	21	small	small	JJ
cord-018089-m94q75xn	233	22	particle	particle	NN
cord-018089-m94q75xn	233	23	aerosols	aerosol	NNS
cord-018089-m94q75xn	233	24	relative	relative	JJ
cord-018089-m94q75xn	233	25	to	to	IN
cord-018089-m94q75xn	233	26	large	large	JJ
cord-018089-m94q75xn	233	27	respiratory	respiratory	JJ
cord-018089-m94q75xn	233	28	droplets	droplet	NNS
cord-018089-m94q75xn	233	29	is	be	VBZ
cord-018089-m94q75xn	233	30	unknown	unknown	JJ
cord-018089-m94q75xn	233	31	.	.	.
cord-018089-m94q75xn	234	1	In	in	IN
cord-018089-m94q75xn	234	2	addition	addition	NN
cord-018089-m94q75xn	234	3	,	,	,
cord-018089-m94q75xn	234	4	the	the	DT
cord-018089-m94q75xn	234	5	role	role	NN
cord-018089-m94q75xn	234	6	of	of	IN
cord-018089-m94q75xn	234	7	fomites	fomite	NNS
cord-018089-m94q75xn	234	8	is	be	VBZ
cord-018089-m94q75xn	234	9	questionable	questionable	JJ
cord-018089-m94q75xn	234	10	.	.	.
cord-018089-m94q75xn	235	1	Until	until	IN
cord-018089-m94q75xn	235	2	recently	recently	RB
cord-018089-m94q75xn	235	3	,	,	,
cord-018089-m94q75xn	235	4	ferrets	ferret	NNS
cord-018089-m94q75xn	235	5	have	have	VBP
cord-018089-m94q75xn	235	6	served	serve	VBN
cord-018089-m94q75xn	235	7	as	as	IN
cord-018089-m94q75xn	235	8	the	the	DT
cord-018089-m94q75xn	235	9	only	only	JJ
cord-018089-m94q75xn	235	10	animal	animal	NN
cord-018089-m94q75xn	235	11	model	model	NN
cord-018089-m94q75xn	235	12	for	for	IN
cord-018089-m94q75xn	235	13	the	the	DT
cord-018089-m94q75xn	235	14	study	study	NN
cord-018089-m94q75xn	235	15	of	of	IN
cord-018089-m94q75xn	235	16	influenza	influenza	NN
cord-018089-m94q75xn	235	17	virus	virus	NN
cord-018089-m94q75xn	235	18	transmission	transmission	NN
cord-018089-m94q75xn	235	19	.	.	.
cord-018089-m94q75xn	236	1	A	a	DT
cord-018089-m94q75xn	236	2	novel	novel	JJ
cord-018089-m94q75xn	236	3	mammalian	mammalian	JJ
cord-018089-m94q75xn	236	4	model	model	NN
cord-018089-m94q75xn	236	5	using	use	VBG
cord-018089-m94q75xn	236	6	the	the	DT
cord-018089-m94q75xn	236	7	guinea	guinea	NN
cord-018089-m94q75xn	236	8	pig	pig	NN
cord-018089-m94q75xn	236	9	has	have	VBZ
cord-018089-m94q75xn	236	10	recently	recently	RB
cord-018089-m94q75xn	236	11	been	be	VBN
cord-018089-m94q75xn	236	12	developed	develop	VBN
cord-018089-m94q75xn	236	13	to	to	TO
cord-018089-m94q75xn	236	14	overcome	overcome	VB
cord-018089-m94q75xn	236	15	the	the	DT
cord-018089-m94q75xn	236	16	limitations	limitation	NNS
cord-018089-m94q75xn	236	17	of	of	IN
cord-018089-m94q75xn	236	18	the	the	DT
cord-018089-m94q75xn	236	19	ferret	ferret	JJ
cord-018089-m94q75xn	236	20	model	model	NN
cord-018089-m94q75xn	236	21	.	.	.
cord-018089-m94q75xn	237	1	Guinea	guinea	NN
cord-018089-m94q75xn	237	2	pigs	pig	NNS
cord-018089-m94q75xn	237	3	are	be	VBP
cord-018089-m94q75xn	237	4	highly	highly	RB
cord-018089-m94q75xn	237	5	susceptible	susceptible	JJ
cord-018089-m94q75xn	237	6	to	to	IN
cord-018089-m94q75xn	237	7	infection	infection	NN
cord-018089-m94q75xn	237	8	with	with	IN
cord-018089-m94q75xn	237	9	an	an	DT
cord-018089-m94q75xn	237	10	unadapted	unadapted	JJ
cord-018089-m94q75xn	237	11	human	human	JJ
cord-018089-m94q75xn	237	12	H3N3	H3N3	NNP
cord-018089-m94q75xn	237	13	(	(	-LRB-
cord-018089-m94q75xn	237	14	A	A	NNP
cord-018089-m94q75xn	237	15	/	/	,
cord-018089-m94q75xn	237	16	Panama/2002/1999	Panama/2002/1999	NNP
cord-018089-m94q75xn	237	17	,	,	,
cord-018089-m94q75xn	237	18	or	or	CC
cord-018089-m94q75xn	237	19	Pan99	Pan99	NNP
cord-018089-m94q75xn	237	20	)	)	-RRB-
cord-018089-m94q75xn	237	21	influenza	influenza	NN
cord-018089-m94q75xn	237	22	virus	virus	NN
cord-018089-m94q75xn	237	23	,	,	,
cord-018089-m94q75xn	237	24	with	with	IN
cord-018089-m94q75xn	237	25	a	a	DT
cord-018089-m94q75xn	237	26	50	50	CD
cord-018089-m94q75xn	237	27	%	%	NN
cord-018089-m94q75xn	237	28	infectious	infectious	JJ
cord-018089-m94q75xn	237	29	dose	dose	NN
cord-018089-m94q75xn	237	30	of	of	IN
cord-018089-m94q75xn	237	31	5	5	CD
cord-018089-m94q75xn	237	32	PFU	pfu	NN
cord-018089-m94q75xn	237	33	,	,	,
cord-018089-m94q75xn	237	34	and	and	CC
cord-018089-m94q75xn	237	35	this	this	DT
cord-018089-m94q75xn	237	36	virus	virus	NN
cord-018089-m94q75xn	237	37	grows	grow	VBZ
cord-018089-m94q75xn	237	38	to	to	IN
cord-018089-m94q75xn	237	39	high	high	JJ
cord-018089-m94q75xn	237	40	titers	titer	NNS
cord-018089-m94q75xn	237	41	in	in	IN
cord-018089-m94q75xn	237	42	the	the	DT
cord-018089-m94q75xn	237	43	upper	upper	JJ
cord-018089-m94q75xn	237	44	respiratory	respiratory	JJ
cord-018089-m94q75xn	237	45	tract	tract	NN
cord-018089-m94q75xn	237	46	and	and	CC
cord-018089-m94q75xn	237	47	to	to	TO
cord-018089-m94q75xn	237	48	moderate	moderate	VB
cord-018089-m94q75xn	237	49	titers	titer	NNS
cord-018089-m94q75xn	237	50	in	in	IN
cord-018089-m94q75xn	237	51	the	the	DT
cord-018089-m94q75xn	237	52	lungs	lung	NNS
cord-018089-m94q75xn	237	53	.	.	.
cord-018089-m94q75xn	238	1	Transmission	transmission	NN
cord-018089-m94q75xn	238	2	of	of	IN
cord-018089-m94q75xn	238	3	Pan99	Pan99	NNP
cord-018089-m94q75xn	238	4	by	by	IN
cord-018089-m94q75xn	238	5	direct	direct	JJ
cord-018089-m94q75xn	238	6	contact	contact	NN
cord-018089-m94q75xn	238	7	and	and	CC
cord-018089-m94q75xn	238	8	aerosol	aerosol	NN
cord-018089-m94q75xn	238	9	in	in	IN
cord-018089-m94q75xn	238	10	this	this	DT
cord-018089-m94q75xn	238	11	system	system	NN
cord-018089-m94q75xn	238	12	is	be	VBZ
cord-018089-m94q75xn	238	13	100	100	CD
cord-018089-m94q75xn	238	14	%	%	NN
cord-018089-m94q75xn	238	15	(	(	-LRB-
cord-018089-m94q75xn	238	16	Fig	Fig	NNP
cord-018089-m94q75xn	238	17	.	.	.
cord-018089-m94q75xn	238	18	6	6	CD
cord-018089-m94q75xn	238	19	)	)	-RRB-
cord-018089-m94q75xn	239	1	[	[	-LRB-
cord-018089-m94q75xn	239	2	153	153	CD
cord-018089-m94q75xn	239	3	]	]	-RRB-
cord-018089-m94q75xn	239	4	;	;	:
cord-018089-m94q75xn	239	5	however	however	RB
cord-018089-m94q75xn	239	6	,	,	,
cord-018089-m94q75xn	239	7	transmission	transmission	NN
cord-018089-m94q75xn	239	8	efficiency	efficiency	NN
cord-018089-m94q75xn	239	9	may	may	MD
cord-018089-m94q75xn	239	10	vary	vary	VB
cord-018089-m94q75xn	239	11	among	among	IN
cord-018089-m94q75xn	239	12	influenza	influenza	NN
cord-018089-m94q75xn	239	13	virus	virus	NN
cord-018089-m94q75xn	239	14	subtypes	subtype	NNS
cord-018089-m94q75xn	239	15	[	[	-LRB-
cord-018089-m94q75xn	239	16	154	154	CD
cord-018089-m94q75xn	239	17	]	]	-RRB-
cord-018089-m94q75xn	239	18	.	.	.
cord-018089-m94q75xn	240	1	Environmental	environmental	JJ
cord-018089-m94q75xn	240	2	factors	factor	NNS
cord-018089-m94q75xn	240	3	such	such	JJ
cord-018089-m94q75xn	240	4	as	as	IN
cord-018089-m94q75xn	240	5	temperature	temperature	NN
cord-018089-m94q75xn	240	6	and	and	CC
cord-018089-m94q75xn	240	7	relative	relative	JJ
cord-018089-m94q75xn	240	8	humidity	humidity	NN
cord-018089-m94q75xn	240	9	also	also	RB
cord-018089-m94q75xn	240	10	appear	appear	VBP
cord-018089-m94q75xn	240	11	to	to	TO
cord-018089-m94q75xn	240	12	play	play	VB
cord-018089-m94q75xn	240	13	a	a	DT
cord-018089-m94q75xn	240	14	substantial	substantial	JJ
cord-018089-m94q75xn	240	15	role	role	NN
cord-018089-m94q75xn	240	16	[	[	-LRB-
cord-018089-m94q75xn	240	17	155	155	CD
cord-018089-m94q75xn	240	18	,	,	,
cord-018089-m94q75xn	240	19	156	156	CD
cord-018089-m94q75xn	240	20	]	]	-RRB-
cord-018089-m94q75xn	240	21	.	.	.
cord-018089-m94q75xn	241	1	Control	control	NN
cord-018089-m94q75xn	241	2	of	of	IN
cord-018089-m94q75xn	241	3	influenza	influenza	NN
cord-018089-m94q75xn	241	4	virus	virus	NN
cord-018089-m94q75xn	241	5	spread	spread	VBN
cord-018089-m94q75xn	241	6	during	during	IN
cord-018089-m94q75xn	241	7	interpandemic	interpandemic	NNP
cord-018089-m94q75xn	241	8	and	and	CC
cord-018089-m94q75xn	241	9	pandemic	pandemic	NN
cord-018089-m94q75xn	241	10	periods	period	NNS
cord-018089-m94q75xn	241	11	through	through	IN
cord-018089-m94q75xn	241	12	vaccination	vaccination	NN
cord-018089-m94q75xn	241	13	[	[	-LRB-
cord-018089-m94q75xn	241	14	157	157	CD
cord-018089-m94q75xn	241	15	]	]	-RRB-
cord-018089-m94q75xn	241	16	and	and	CC
cord-018089-m94q75xn	241	17	physical	physical	JJ
cord-018089-m94q75xn	241	18	means	mean	NNS
cord-018089-m94q75xn	241	19	will	will	MD
cord-018089-m94q75xn	241	20	be	be	VB
cord-018089-m94q75xn	241	21	paramount	paramount	JJ
cord-018089-m94q75xn	241	22	to	to	IN
cord-018089-m94q75xn	241	23	abrogating	abrogate	VBG
cord-018089-m94q75xn	241	24	person	person	NN
cord-018089-m94q75xn	241	25	-	-	HYPH
cord-018089-m94q75xn	241	26	to	to	IN
cord-018089-m94q75xn	241	27	-	-	HYPH
cord-018089-m94q75xn	241	28	person	person	NN
cord-018089-m94q75xn	241	29	transmission	transmission	NN
cord-018089-m94q75xn	241	30	and	and	CC
cord-018089-m94q75xn	241	31	is	be	VBZ
cord-018089-m94q75xn	241	32	crucial	crucial	JJ
cord-018089-m94q75xn	241	33	where	where	WRB
cord-018089-m94q75xn	241	34	viruses	virus	NNS
cord-018089-m94q75xn	241	35	are	be	VBP
cord-018089-m94q75xn	241	36	resistant	resistant	JJ
cord-018089-m94q75xn	241	37	to	to	IN
cord-018089-m94q75xn	241	38	currently	currently	RB
cord-018089-m94q75xn	241	39	available	available	JJ
cord-018089-m94q75xn	241	40	antivirals	antiviral	NNS
cord-018089-m94q75xn	241	41	.	.	.
cord-018089-m94q75xn	242	1	Effective	effective	JJ
cord-018089-m94q75xn	242	2	and	and	CC
cord-018089-m94q75xn	242	3	timely	timely	JJ
cord-018089-m94q75xn	242	4	vaccine	vaccine	NN
cord-018089-m94q75xn	242	5	development	development	NN
cord-018089-m94q75xn	242	6	depends	depend	VBZ
cord-018089-m94q75xn	242	7	on	on	IN
cord-018089-m94q75xn	242	8	in	in	IN
cord-018089-m94q75xn	242	9	-	-	HYPH
cord-018089-m94q75xn	242	10	depth	depth	NN
cord-018089-m94q75xn	242	11	understanding	understanding	NN
cord-018089-m94q75xn	242	12	of	of	IN
cord-018089-m94q75xn	242	13	influenza	influenza	NN
cord-018089-m94q75xn	242	14	virus	virus	NN
cord-018089-m94q75xn	242	15	biology	biology	NN
cord-018089-m94q75xn	242	16	.	.	.
cord-018089-m94q75xn	243	1	Although	although	IN
cord-018089-m94q75xn	243	2	recent	recent	JJ
cord-018089-m94q75xn	243	3	advances	advance	NNS
cord-018089-m94q75xn	243	4	have	have	VBP
cord-018089-m94q75xn	243	5	been	be	VBN
cord-018089-m94q75xn	243	6	made	make	VBN
cord-018089-m94q75xn	243	7	,	,	,
cord-018089-m94q75xn	243	8	ongoing	ongoing	JJ
cord-018089-m94q75xn	243	9	research	research	NN
cord-018089-m94q75xn	243	10	will	will	MD
cord-018089-m94q75xn	243	11	be	be	VB
cord-018089-m94q75xn	243	12	required	require	VBN
cord-018089-m94q75xn	243	13	to	to	TO
cord-018089-m94q75xn	243	14	fulfill	fulfill	VB
cord-018089-m94q75xn	243	15	this	this	DT
cord-018089-m94q75xn	243	16	goal	goal	NN
cord-018089-m94q75xn	243	17	.	.	.
cord-018089-m94q75xn	244	1	Identification	identification	NN
cord-018089-m94q75xn	244	2	and	and	CC
cord-018089-m94q75xn	244	3	characterization	characterization	NN
cord-018089-m94q75xn	244	4	of	of	IN
cord-018089-m94q75xn	244	5	days	day	NNS
cord-018089-m94q75xn	244	6	post	post	NN
cord-018089-m94q75xn	244	7	-	-	JJ
cord-018089-m94q75xn	244	8	infection	infection	JJ
cord-018089-m94q75xn	244	9	nasal	nasal	NN
cord-018089-m94q75xn	244	10	wash	wash	NN
cord-018089-m94q75xn	244	11	titre	titre	NNP
cord-018089-m94q75xn	244	12	(	(	-LRB-
cord-018089-m94q75xn	244	13	log	log	VB
cord-018089-m94q75xn	244	14	10	10	CD
cord-018089-m94q75xn	245	1	PFU	PFU	NNP
cord-018089-m94q75xn	245	2	/	/	SYM
cord-018089-m94q75xn	245	3	ml	ml	NN
cord-018089-m94q75xn	245	4	)	)	-RRB-
cord-018089-m94q75xn	246	1	AIR	AIR	NNP
cord-018089-m94q75xn	246	2	FLOW	FLOW	NNP
cord-018089-m94q75xn	246	3	exposed	expose	VBD
cord-018089-m94q75xn	246	4	inoculated	inoculate	VBN
cord-018089-m94q75xn	246	5	exposed	expose	VBN
cord-018089-m94q75xn	246	6	inoculated	inoculate	VBN
cord-018089-m94q75xn	246	7	exposed	expose	VBN
cord-018089-m94q75xn	246	8	inoculated	inoculate	VBN
cord-018089-m94q75xn	246	9	Fig	Fig	NNP
cord-018089-m94q75xn	246	10	.	.	.
cord-018089-m94q75xn	246	11	6	6	CD
cord-018089-m94q75xn	247	1	Close	close	JJ
cord-018089-m94q75xn	247	2	range	range	NN
cord-018089-m94q75xn	247	3	transmission	transmission	NN
cord-018089-m94q75xn	247	4	of	of	IN
cord-018089-m94q75xn	247	5	human	human	JJ
cord-018089-m94q75xn	247	6	influenza	influenza	NN
cord-018089-m94q75xn	247	7	A	a	NN
cord-018089-m94q75xn	247	8	among	among	IN
cord-018089-m94q75xn	247	9	guinea	guinea	NN
cord-018089-m94q75xn	247	10	pigs	pig	NNS
cord-018089-m94q75xn	247	11	.	.	.
cord-018089-m94q75xn	248	1	Inoculated	inoculate	VBN
cord-018089-m94q75xn	248	2	animals	animal	NNS
cord-018089-m94q75xn	248	3	placed	place	VBN
cord-018089-m94q75xn	248	4	in	in	IN
cord-018089-m94q75xn	248	5	proximity	proximity	NN
cord-018089-m94q75xn	248	6	to	to	IN
cord-018089-m94q75xn	248	7	uninoculated	uninoculated	JJ
cord-018089-m94q75xn	248	8	animals	animal	NNS
cord-018089-m94q75xn	248	9	(	(	-LRB-
cord-018089-m94q75xn	248	10	without	without	IN
cord-018089-m94q75xn	248	11	direct	direct	JJ
cord-018089-m94q75xn	248	12	contact	contact	NN
cord-018089-m94q75xn	248	13	)	)	-RRB-
cord-018089-m94q75xn	248	14	spread	spread	VBD
cord-018089-m94q75xn	248	15	Pan99	Pan99	NNP
cord-018089-m94q75xn	248	16	to	to	IN
cord-018089-m94q75xn	248	17	all	all	DT
cord-018089-m94q75xn	248	18	exposed	expose	VBN
cord-018089-m94q75xn	248	19	animals	animal	NNS
cord-018089-m94q75xn	248	20	.	.	.
cord-018089-m94q75xn	249	1	Adapted	adapt	VBN
cord-018089-m94q75xn	249	2	from	from	IN
cord-018089-m94q75xn	249	3	[	[	-LRB-
cord-018089-m94q75xn	249	4	109	109	CD
cord-018089-m94q75xn	249	5	]	]	-RRB-
cord-018089-m94q75xn	249	6	the	the	DT
cord-018089-m94q75xn	249	7	molecular	molecular	JJ
cord-018089-m94q75xn	249	8	signatures	signature	NNS
cord-018089-m94q75xn	249	9	required	require	VBN
cord-018089-m94q75xn	249	10	for	for	IN
cord-018089-m94q75xn	249	11	transmission	transmission	NN
cord-018089-m94q75xn	249	12	will	will	MD
cord-018089-m94q75xn	249	13	be	be	VB
cord-018089-m94q75xn	249	14	of	of	IN
cord-018089-m94q75xn	249	15	utmost	utmost	JJ
cord-018089-m94q75xn	249	16	importance	importance	NN
cord-018089-m94q75xn	249	17	to	to	IN
cord-018089-m94q75xn	249	18	preventing	prevent	VBG
cord-018089-m94q75xn	249	19	further	further	JJ
cord-018089-m94q75xn	249	20	influenza	influenza	NN
cord-018089-m94q75xn	249	21	virus	virus	NN
cord-018089-m94q75xn	249	22	pandemics	pandemic	NNS
cord-018089-m94q75xn	249	23	.	.	.
cord-018089-m94q75xn	250	1	Globalization	globalization	NN
cord-018089-m94q75xn	250	2	of	of	IN
cord-018089-m94q75xn	250	3	H1N1	H1N1	NNP
cord-018089-m94q75xn	250	4	infection	infection	NN
cord-018089-m94q75xn	250	5	in	in	IN
cord-018089-m94q75xn	250	6	humans	human	NNS
cord-018089-m94q75xn	250	7	requires	require	VBZ
cord-018089-m94q75xn	250	8	parallel	parallel	JJ
cord-018089-m94q75xn	250	9	efforts	effort	NNS
cord-018089-m94q75xn	250	10	on	on	IN
cord-018089-m94q75xn	250	11	behalf	behalf	NN
cord-018089-m94q75xn	250	12	of	of	IN
cord-018089-m94q75xn	250	13	virologists	virologist	NNS
cord-018089-m94q75xn	250	14	in	in	IN
cord-018089-m94q75xn	250	15	conjunction	conjunction	NN
cord-018089-m94q75xn	250	16	with	with	IN
cord-018089-m94q75xn	250	17	epidemiologists	epidemiologist	NNS
cord-018089-m94q75xn	250	18	and	and	CC
cord-018089-m94q75xn	250	19	other	other	JJ
cord-018089-m94q75xn	250	20	members	member	NNS
cord-018089-m94q75xn	250	21	of	of	IN
cord-018089-m94q75xn	250	22	the	the	DT
cord-018089-m94q75xn	250	23	public	public	JJ
cord-018089-m94q75xn	250	24	health	health	NN
cord-018089-m94q75xn	250	25	community	community	NN
cord-018089-m94q75xn	250	26	to	to	TO
cord-018089-m94q75xn	250	27	translate	translate	VB
cord-018089-m94q75xn	250	28	the	the	DT
cord-018089-m94q75xn	250	29	growing	grow	VBG
cord-018089-m94q75xn	250	30	body	body	NN
cord-018089-m94q75xn	250	31	of	of	IN
cord-018089-m94q75xn	250	32	knowledge	knowledge	NN
cord-018089-m94q75xn	250	33	into	into	IN
cord-018089-m94q75xn	250	34	means	mean	NNS
cord-018089-m94q75xn	250	35	by	by	IN
cord-018089-m94q75xn	250	36	which	which	WDT
cord-018089-m94q75xn	250	37	influenza	influenza	NN
cord-018089-m94q75xn	250	38	spread	spread	NN
cord-018089-m94q75xn	250	39	can	can	MD
cord-018089-m94q75xn	250	40	be	be	VB
cord-018089-m94q75xn	250	41	controlled	control	VBN
cord-018089-m94q75xn	250	42	.	.	.
cord-018089-m94q75xn	250	43	 	 	_SP
cord-018089-m94q75xn	251	1	Antigenic	antigenic	JJ
cord-018089-m94q75xn	251	2	and	and	CC
cord-018089-m94q75xn	251	3	genetic	genetic	JJ
cord-018089-m94q75xn	251	4	characteristics	characteristic	NNS
cord-018089-m94q75xn	251	5	of	of	IN
cord-018089-m94q75xn	251	6	swine	swine	NN
cord-018089-m94q75xn	251	7	-	-	HYPH
cord-018089-m94q75xn	251	8	origin	origin	NN
cord-018089-m94q75xn	251	9	2009	2009	CD
cord-018089-m94q75xn	251	10	A(H1N1	a(h1n1	CD
cord-018089-m94q75xn	251	11	)	)	-RRB-
cord-018089-m94q75xn	252	1	influenza	influenza	NN
cord-018089-m94q75xn	252	2	viruses	virus	NNS
cord-018089-m94q75xn	252	3	circulating	circulate	VBG
cord-018089-m94q75xn	252	4	in	in	IN
cord-018089-m94q75xn	252	5	humans	human	NNS
cord-018089-m94q75xn	252	6	Triple	triple	JJ
cord-018089-m94q75xn	252	7	-	-	HYPH
cord-018089-m94q75xn	252	8	reassortant	reassortant	JJ
cord-018089-m94q75xn	252	9	swine	swine	NN
cord-018089-m94q75xn	252	10	influenza	influenza	NN
cord-018089-m94q75xn	252	11	A	a	NN
cord-018089-m94q75xn	252	12	(	(	-LRB-
cord-018089-m94q75xn	252	13	H1	H1	NNP
cord-018089-m94q75xn	252	14	)	)	-RRB-
cord-018089-m94q75xn	252	15	in	in	IN
cord-018089-m94q75xn	252	16	humans	human	NNS
cord-018089-m94q75xn	252	17	in	in	IN
cord-018089-m94q75xn	252	18	the	the	DT
cord-018089-m94q75xn	252	19	United	United	NNP
cord-018089-m94q75xn	252	20	States	States	NNP
cord-018089-m94q75xn	252	21	Orthomyxoviridae	Orthomyxoviridae	NNP
cord-018089-m94q75xn	252	22	:	:	:
cord-018089-m94q75xn	252	23	the	the	DT
cord-018089-m94q75xn	252	24	viruses	virus	NNS
cord-018089-m94q75xn	252	25	and	and	CC
cord-018089-m94q75xn	252	26	their	-PRON-	PRP$
cord-018089-m94q75xn	252	27	replication	replication	NN
cord-018089-m94q75xn	252	28	Rescue	Rescue	NNP
cord-018089-m94q75xn	252	29	of	of	IN
cord-018089-m94q75xn	252	30	influenza	influenza	NN
cord-018089-m94q75xn	252	31	A	a	DT
cord-018089-m94q75xn	252	32	virus	virus	NN
cord-018089-m94q75xn	252	33	from	from	IN
cord-018089-m94q75xn	252	34	recombinant	recombinant	JJ
cord-018089-m94q75xn	252	35	DNA	DNA	NNP
cord-018089-m94q75xn	252	36	Generation	Generation	NNP
cord-018089-m94q75xn	252	37	of	of	IN
cord-018089-m94q75xn	252	38	influenza	influenza	NN
cord-018089-m94q75xn	252	39	A	a	DT
cord-018089-m94q75xn	252	40	viruses	virus	NNS
cord-018089-m94q75xn	252	41	entirely	entirely	RB
cord-018089-m94q75xn	252	42	from	from	IN
cord-018089-m94q75xn	252	43	cloned	clone	VBN
cord-018089-m94q75xn	253	1	cDNAs	cdnas	LS
cord-018089-m94q75xn	253	2	Characterization	characterization	NN
cord-018089-m94q75xn	253	3	of	of	IN
cord-018089-m94q75xn	253	4	the	the	DT
cord-018089-m94q75xn	253	5	reconstructed	reconstructed	JJ
cord-018089-m94q75xn	253	6	1918	1918	CD
cord-018089-m94q75xn	253	7	Spanish	spanish	JJ
cord-018089-m94q75xn	253	8	influenza	influenza	NN
cord-018089-m94q75xn	253	9	pandemic	pandemic	NN
cord-018089-m94q75xn	253	10	virus	virus	NN
cord-018089-m94q75xn	253	11	World	World	NNP
cord-018089-m94q75xn	253	12	Health	Health	NNP
cord-018089-m94q75xn	253	13	Organization	Organization	NNP
cord-018089-m94q75xn	253	14	Global	Global	NNP
cord-018089-m94q75xn	253	15	Influenza	Influenza	NNP
cord-018089-m94q75xn	253	16	Program	Program	NNP
cord-018089-m94q75xn	253	17	Surveillance	Surveillance	NNP
cord-018089-m94q75xn	253	18	Network	Network	NNP
cord-018089-m94q75xn	253	19	Large	large	JJ
cord-018089-m94q75xn	253	20	-	-	HYPH
cord-018089-m94q75xn	253	21	scale	scale	NN
cord-018089-m94q75xn	253	22	sequencing	sequencing	NN
cord-018089-m94q75xn	253	23	of	of	IN
cord-018089-m94q75xn	253	24	human	human	JJ
cord-018089-m94q75xn	253	25	influenza	influenza	NN
cord-018089-m94q75xn	253	26	reveals	reveal	VBZ
cord-018089-m94q75xn	253	27	the	the	DT
cord-018089-m94q75xn	253	28	dynamic	dynamic	JJ
cord-018089-m94q75xn	253	29	nature	nature	NN
cord-018089-m94q75xn	253	30	of	of	IN
cord-018089-m94q75xn	253	31	viral	viral	JJ
cord-018089-m94q75xn	253	32	genome	genome	NN
cord-018089-m94q75xn	253	33	evolution	evolution	NN
cord-018089-m94q75xn	253	34	Intranasal	Intranasal	NNP
cord-018089-m94q75xn	253	35	administration	administration	NN
cord-018089-m94q75xn	253	36	of	of	IN
cord-018089-m94q75xn	253	37	alpha	alpha	NNP
cord-018089-m94q75xn	253	38	interferon	interferon	NNP
cord-018089-m94q75xn	253	39	reduces	reduce	VBZ
cord-018089-m94q75xn	253	40	seasonal	seasonal	JJ
cord-018089-m94q75xn	253	41	influenza	influenza	NN
cord-018089-m94q75xn	253	42	A	a	DT
cord-018089-m94q75xn	253	43	virus	virus	NN
cord-018089-m94q75xn	253	44	morbidity	morbidity	NN
cord-018089-m94q75xn	253	45	in	in	IN
cord-018089-m94q75xn	253	46	ferrets	ferret	NNS
cord-018089-m94q75xn	253	47	Live	live	VBP
cord-018089-m94q75xn	253	48	attenuated	attenuated	JJ
cord-018089-m94q75xn	253	49	influenza	influenza	NN
cord-018089-m94q75xn	253	50	viruses	virus	NNS
cord-018089-m94q75xn	253	51	containing	contain	VBG
cord-018089-m94q75xn	253	52	NS1	ns1	NN
cord-018089-m94q75xn	253	53	truncations	truncation	NNS
cord-018089-m94q75xn	253	54	as	as	IN
cord-018089-m94q75xn	253	55	vaccine	vaccine	NN
cord-018089-m94q75xn	253	56	candidates	candidate	NNS
cord-018089-m94q75xn	253	57	against	against	IN
cord-018089-m94q75xn	253	58	H5N1	H5N1	NNP
cord-018089-m94q75xn	253	59	highly	highly	RB
cord-018089-m94q75xn	253	60	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	253	61	avian	avian	JJ
cord-018089-m94q75xn	253	62	influenza	influenza	NN
cord-018089-m94q75xn	253	63	Influenza	Influenza	NNP
cord-018089-m94q75xn	253	64	B	B	NNP
cord-018089-m94q75xn	253	65	virus	virus	NN
cord-018089-m94q75xn	253	66	NS1-truncated	ns1-truncate	VBN
cord-018089-m94q75xn	253	67	mutants	mutant	NNS
cord-018089-m94q75xn	253	68	:	:	:
cord-018089-m94q75xn	253	69	live	live	RB
cord-018089-m94q75xn	253	70	-	-	HYPH
cord-018089-m94q75xn	253	71	attenuated	attenuated	JJ
cord-018089-m94q75xn	253	72	vaccine	vaccine	NN
cord-018089-m94q75xn	253	73	approach	approach	NN
cord-018089-m94q75xn	253	74	Live	live	RB
cord-018089-m94q75xn	253	75	,	,	,
cord-018089-m94q75xn	253	76	attenuated	attenuated	JJ
cord-018089-m94q75xn	253	77	influenza	influenza	NN
cord-018089-m94q75xn	253	78	A	a	DT
cord-018089-m94q75xn	253	79	H5N1	H5N1	NNP
cord-018089-m94q75xn	253	80	candidate	candidate	NN
cord-018089-m94q75xn	253	81	vaccines	vaccine	NNS
cord-018089-m94q75xn	253	82	provide	provide	VBP
cord-018089-m94q75xn	253	83	broad	broad	JJ
cord-018089-m94q75xn	253	84	cross	cross	NN
cord-018089-m94q75xn	253	85	-	-	NN
cord-018089-m94q75xn	253	86	protection	protection	NN
cord-018089-m94q75xn	253	87	in	in	IN
cord-018089-m94q75xn	253	88	mice	mouse	NNS
cord-018089-m94q75xn	253	89	and	and	CC
cord-018089-m94q75xn	253	90	ferrets	ferret	NNS
cord-018089-m94q75xn	253	91	Principles	principle	NNS
cord-018089-m94q75xn	253	92	underlying	underlie	VBG
cord-018089-m94q75xn	253	93	the	the	DT
cord-018089-m94q75xn	253	94	development	development	NN
cord-018089-m94q75xn	253	95	and	and	CC
cord-018089-m94q75xn	253	96	use	use	NN
cord-018089-m94q75xn	253	97	of	of	IN
cord-018089-m94q75xn	253	98	live	live	JJ
cord-018089-m94q75xn	253	99	attenuated	attenuated	JJ
cord-018089-m94q75xn	253	100	cold	cold	NN
cord-018089-m94q75xn	253	101	-	-	HYPH
cord-018089-m94q75xn	253	102	adapted	adapt	VBN
cord-018089-m94q75xn	253	103	influenza	influenza	NN
cord-018089-m94q75xn	253	104	A	a	NN
cord-018089-m94q75xn	253	105	and	and	CC
cord-018089-m94q75xn	253	106	B	B	NNP
cord-018089-m94q75xn	253	107	virus	virus	NN
cord-018089-m94q75xn	254	1	vaccines	vaccine	NNS
cord-018089-m94q75xn	254	2	Influenza	Influenza	NNP
cord-018089-m94q75xn	254	3	virus	virus	NN
cord-018089-m94q75xn	254	4	and	and	CC
cord-018089-m94q75xn	254	5	CNS	cns	JJ
cord-018089-m94q75xn	254	6	manifestations	manifestation	NNS
cord-018089-m94q75xn	255	1	Toxic	toxic	JJ
cord-018089-m94q75xn	255	2	shock	shock	NN
cord-018089-m94q75xn	255	3	syndrome	syndrome	NN
cord-018089-m94q75xn	255	4	complicating	complicate	VBG
cord-018089-m94q75xn	255	5	influenza	influenza	NN
cord-018089-m94q75xn	255	6	A	a	DT
cord-018089-m94q75xn	255	7	infection	infection	NN
cord-018089-m94q75xn	256	1	:	:	:
cord-018089-m94q75xn	256	2	a	a	DT
cord-018089-m94q75xn	256	3	two	two	CD
cord-018089-m94q75xn	256	4	-	-	HYPH
cord-018089-m94q75xn	256	5	case	case	NN
cord-018089-m94q75xn	256	6	report	report	NN
cord-018089-m94q75xn	256	7	with	with	IN
cord-018089-m94q75xn	256	8	one	one	CD
cord-018089-m94q75xn	256	9	case	case	NN
cord-018089-m94q75xn	256	10	of	of	IN
cord-018089-m94q75xn	256	11	bacteremia	bacteremia	NN
cord-018089-m94q75xn	256	12	and	and	CC
cord-018089-m94q75xn	256	13	endocarditis	endocarditis	NN
cord-018089-m94q75xn	256	14	Influenza	Influenza	NNP
cord-018089-m94q75xn	256	15	B	B	NNP
cord-018089-m94q75xn	256	16	virus	virus	NN
cord-018089-m94q75xn	256	17	in	in	IN
cord-018089-m94q75xn	256	18	seals	seal	NNS
cord-018089-m94q75xn	256	19	Encephalitis	encephalitis	RB
cord-018089-m94q75xn	256	20	associated	associate	VBN
cord-018089-m94q75xn	256	21	with	with	IN
cord-018089-m94q75xn	256	22	influenza	influenza	NN
cord-018089-m94q75xn	256	23	B	b	NN
cord-018089-m94q75xn	256	24	virus	virus	NN
cord-018089-m94q75xn	256	25	infection	infection	NN
cord-018089-m94q75xn	256	26	in	in	IN
cord-018089-m94q75xn	256	27	2	2	CD
cord-018089-m94q75xn	256	28	children	child	NNS
cord-018089-m94q75xn	256	29	and	and	CC
cord-018089-m94q75xn	256	30	a	a	DT
cord-018089-m94q75xn	256	31	review	review	NN
cord-018089-m94q75xn	256	32	of	of	IN
cord-018089-m94q75xn	256	33	the	the	DT
cord-018089-m94q75xn	256	34	literature	literature	NN
cord-018089-m94q75xn	256	35	Influenza	Influenza	NNP
cord-018089-m94q75xn	256	36	B	B	NNP
cord-018089-m94q75xn	256	37	virus	virus	NN
cord-018089-m94q75xn	256	38	infection	infection	NN
cord-018089-m94q75xn	256	39	associated	associate	VBN
cord-018089-m94q75xn	256	40	with	with	IN
cord-018089-m94q75xn	256	41	non	non	JJ
cord-018089-m94q75xn	256	42	-	-	JJ
cord-018089-m94q75xn	256	43	bacterial	bacterial	JJ
cord-018089-m94q75xn	256	44	septic	septic	JJ
cord-018089-m94q75xn	256	45	shock	shock	NN
cord-018089-m94q75xn	256	46	-	-	HYPH
cord-018089-m94q75xn	256	47	like	like	JJ
cord-018089-m94q75xn	256	48	illness	illness	NN
cord-018089-m94q75xn	256	49	Exploration	Exploration	NNP
cord-018089-m94q75xn	256	50	of	of	IN
cord-018089-m94q75xn	256	51	the	the	DT
cord-018089-m94q75xn	256	52	emergence	emergence	NN
cord-018089-m94q75xn	256	53	of	of	IN
cord-018089-m94q75xn	256	54	the	the	DT
cord-018089-m94q75xn	256	55	Victoria	Victoria	NNP
cord-018089-m94q75xn	256	56	lineage	lineage	NN
cord-018089-m94q75xn	256	57	of	of	IN
cord-018089-m94q75xn	256	58	influenza	influenza	NN
cord-018089-m94q75xn	256	59	B	b	NN
cord-018089-m94q75xn	256	60	virus	virus	NN
cord-018089-m94q75xn	256	61	Medically	medically	RB
cord-018089-m94q75xn	256	62	attended	attend	VBD
cord-018089-m94q75xn	256	63	pediatric	pediatric	JJ
cord-018089-m94q75xn	256	64	influenza	influenza	NN
cord-018089-m94q75xn	256	65	during	during	IN
cord-018089-m94q75xn	256	66	the	the	DT
cord-018089-m94q75xn	256	67	resurgence	resurgence	NN
cord-018089-m94q75xn	256	68	of	of	IN
cord-018089-m94q75xn	256	69	the	the	DT
cord-018089-m94q75xn	256	70	Victoria	Victoria	NNP
cord-018089-m94q75xn	256	71	lineage	lineage	NN
cord-018089-m94q75xn	256	72	of	of	IN
cord-018089-m94q75xn	256	73	influenza	influenza	NN
cord-018089-m94q75xn	256	74	B	b	NN
cord-018089-m94q75xn	256	75	virus	virus	NN
cord-018089-m94q75xn	257	1	A	a	DT
cord-018089-m94q75xn	257	2	nationwide	nationwide	JJ
cord-018089-m94q75xn	257	3	epidemic	epidemic	NN
cord-018089-m94q75xn	257	4	of	of	IN
cord-018089-m94q75xn	257	5	influenza	influenza	NN
cord-018089-m94q75xn	257	6	C	c	NN
cord-018089-m94q75xn	257	7	virus	virus	NN
cord-018089-m94q75xn	257	8	infection	infection	NN
cord-018089-m94q75xn	257	9	in	in	IN
cord-018089-m94q75xn	257	10	Japan	Japan	NNP
cord-018089-m94q75xn	257	11	in	in	IN
cord-018089-m94q75xn	257	12	2004	2004	CD
cord-018089-m94q75xn	257	13	Genome	Genome	NNP
cord-018089-m94q75xn	257	14	analysis	analysis	NN
cord-018089-m94q75xn	257	15	of	of	IN
cord-018089-m94q75xn	257	16	influenza	influenza	NN
cord-018089-m94q75xn	257	17	C	C	NNP
cord-018089-m94q75xn	257	18	viruses	virus	NNS
cord-018089-m94q75xn	257	19	isolated	isolate	VBN
cord-018089-m94q75xn	257	20	in	in	IN
cord-018089-m94q75xn	257	21	1981/82	1981/82	CD
cord-018089-m94q75xn	257	22	from	from	IN
cord-018089-m94q75xn	257	23	pigs	pig	NNS
cord-018089-m94q75xn	257	24	in	in	IN
cord-018089-m94q75xn	257	25	China	China	NNP
cord-018089-m94q75xn	257	26	Binding	Binding	NNP
cord-018089-m94q75xn	257	27	of	of	IN
cord-018089-m94q75xn	257	28	the	the	DT
cord-018089-m94q75xn	257	29	influenza	influenza	NN
cord-018089-m94q75xn	257	30	A	a	DT
cord-018089-m94q75xn	257	31	virus	virus	NN
cord-018089-m94q75xn	257	32	to	to	IN
cord-018089-m94q75xn	257	33	cellsurface	cellsurface	NNP
cord-018089-m94q75xn	257	34	receptors	receptor	NNS
cord-018089-m94q75xn	257	35	:	:	:
cord-018089-m94q75xn	257	36	structures	structure	NNS
cord-018089-m94q75xn	257	37	of	of	IN
cord-018089-m94q75xn	257	38	five	five	CD
cord-018089-m94q75xn	257	39	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	257	40	-	-	HYPH
cord-018089-m94q75xn	257	41	sialyloligosaccharide	sialyloligosaccharide	NN
cord-018089-m94q75xn	257	42	complexes	complex	NNS
cord-018089-m94q75xn	257	43	determined	determine	VBN
cord-018089-m94q75xn	257	44	by	by	IN
cord-018089-m94q75xn	257	45	X	x	NN
cord-018089-m94q75xn	257	46	-	-	NN
cord-018089-m94q75xn	257	47	ray	ray	JJ
cord-018089-m94q75xn	257	48	crystallography	crystallography	NN
cord-018089-m94q75xn	257	49	Receptor	receptor	NN
cord-018089-m94q75xn	257	50	binding	binding	NN
cord-018089-m94q75xn	257	51	and	and	CC
cord-018089-m94q75xn	257	52	membrane	membrane	NN
cord-018089-m94q75xn	257	53	fusion	fusion	NN
cord-018089-m94q75xn	257	54	in	in	IN
cord-018089-m94q75xn	257	55	virus	virus	NN
cord-018089-m94q75xn	257	56	entry	entry	NN
cord-018089-m94q75xn	257	57	:	:	:
cord-018089-m94q75xn	257	58	the	the	DT
cord-018089-m94q75xn	257	59	influenza	influenza	NN
cord-018089-m94q75xn	257	60	hemagglutinin	hemagglutinin	VBD
cord-018089-m94q75xn	257	61	A	a	DT
cord-018089-m94q75xn	257	62	single	single	JJ
cord-018089-m94q75xn	257	63	amino	amino	NN
cord-018089-m94q75xn	257	64	acid	acid	NN
cord-018089-m94q75xn	257	65	substitution	substitution	NN
cord-018089-m94q75xn	257	66	in	in	IN
cord-018089-m94q75xn	258	1	1918	1918	CD
cord-018089-m94q75xn	258	2	influenza	influenza	NN
cord-018089-m94q75xn	258	3	virus	virus	NN
cord-018089-m94q75xn	258	4	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	258	5	changes	change	VBZ
cord-018089-m94q75xn	258	6	receptor	receptor	NN
cord-018089-m94q75xn	258	7	binding	bind	VBG
cord-018089-m94q75xn	258	8	specificity	specificity	NN
cord-018089-m94q75xn	258	9	Structure	structure	NN
cord-018089-m94q75xn	258	10	and	and	CC
cord-018089-m94q75xn	258	11	receptor	receptor	NN
cord-018089-m94q75xn	258	12	specificity	specificity	NN
cord-018089-m94q75xn	258	13	of	of	IN
cord-018089-m94q75xn	258	14	the	the	DT
cord-018089-m94q75xn	258	15	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	258	16	from	from	IN
cord-018089-m94q75xn	258	17	an	an	DT
cord-018089-m94q75xn	258	18	H5N1	H5N1	NNP
cord-018089-m94q75xn	258	19	influenza	influenza	NN
cord-018089-m94q75xn	258	20	virus	virus	NN
cord-018089-m94q75xn	258	21	Receptor	receptor	NN
cord-018089-m94q75xn	258	22	-	-	HYPH
cord-018089-m94q75xn	258	23	binding	bind	VBG
cord-018089-m94q75xn	258	24	specificity	specificity	NN
cord-018089-m94q75xn	258	25	of	of	IN
cord-018089-m94q75xn	258	26	pandemic	pandemic	NN
cord-018089-m94q75xn	258	27	influenza	influenza	NN
cord-018089-m94q75xn	258	28	A	a	NN
cord-018089-m94q75xn	259	1	(	(	-LRB-
cord-018089-m94q75xn	259	2	H1N1	H1N1	NNP
cord-018089-m94q75xn	259	3	)	)	-RRB-
cord-018089-m94q75xn	259	4	2009	2009	CD
cord-018089-m94q75xn	259	5	virus	virus	NN
cord-018089-m94q75xn	259	6	determined	determine	VBN
cord-018089-m94q75xn	259	7	by	by	IN
cord-018089-m94q75xn	259	8	carbohydrate	carbohydrate	NN
cord-018089-m94q75xn	259	9	microarray	microarray	NN
cord-018089-m94q75xn	259	10	Transmission	transmission	NN
cord-018089-m94q75xn	259	11	and	and	CC
cord-018089-m94q75xn	259	12	pathogenesis	pathogenesis	NN
cord-018089-m94q75xn	259	13	of	of	IN
cord-018089-m94q75xn	259	14	swine	swine	NN
cord-018089-m94q75xn	259	15	-	-	HYPH
cord-018089-m94q75xn	259	16	origin	origin	NN
cord-018089-m94q75xn	259	17	2009	2009	CD
cord-018089-m94q75xn	259	18	A(H1N1	a(h1n1	CD
cord-018089-m94q75xn	259	19	)	)	-RRB-
cord-018089-m94q75xn	260	1	influenza	influenza	NN
cord-018089-m94q75xn	260	2	viruses	virus	NNS
cord-018089-m94q75xn	260	3	in	in	IN
cord-018089-m94q75xn	260	4	ferrets	ferret	NNS
cord-018089-m94q75xn	260	5	and	and	CC
cord-018089-m94q75xn	260	6	mice	mouse	NNS
cord-018089-m94q75xn	260	7	Human	Human	NNP
cord-018089-m94q75xn	260	8	HA	HA	NNP
cord-018089-m94q75xn	260	9	and	and	CC
cord-018089-m94q75xn	260	10	polymerase	polymerase	NN
cord-018089-m94q75xn	261	1	subunit	subunit	NNP
cord-018089-m94q75xn	261	2	PB2	PB2	NNP
cord-018089-m94q75xn	261	3	proteins	protein	NNS
cord-018089-m94q75xn	261	4	confer	confer	VBP
cord-018089-m94q75xn	261	5	transmission	transmission	NN
cord-018089-m94q75xn	261	6	of	of	IN
cord-018089-m94q75xn	261	7	an	an	DT
cord-018089-m94q75xn	261	8	avian	avian	JJ
cord-018089-m94q75xn	261	9	influenza	influenza	NN
cord-018089-m94q75xn	261	10	virus	virus	NN
cord-018089-m94q75xn	261	11	through	through	IN
cord-018089-m94q75xn	261	12	the	the	DT
cord-018089-m94q75xn	261	13	air	air	NN
cord-018089-m94q75xn	261	14	Minimal	minimal	JJ
cord-018089-m94q75xn	261	15	molecular	molecular	JJ
cord-018089-m94q75xn	261	16	constraints	constraint	NNS
cord-018089-m94q75xn	261	17	for	for	IN
cord-018089-m94q75xn	261	18	respiratory	respiratory	JJ
cord-018089-m94q75xn	261	19	droplet	droplet	NN
cord-018089-m94q75xn	261	20	transmission	transmission	NN
cord-018089-m94q75xn	261	21	of	of	IN
cord-018089-m94q75xn	261	22	an	an	DT
cord-018089-m94q75xn	261	23	avian	avian	JJ
cord-018089-m94q75xn	261	24	-	-	HYPH
cord-018089-m94q75xn	261	25	human	human	JJ
cord-018089-m94q75xn	261	26	H9N2	H9N2	NNP
cord-018089-m94q75xn	261	27	influenza	influenza	NN
cord-018089-m94q75xn	261	28	A	a	DT
cord-018089-m94q75xn	261	29	virus	virus	NN
cord-018089-m94q75xn	261	30	Viral	viral	JJ
cord-018089-m94q75xn	261	31	entry	entry	NN
cord-018089-m94q75xn	261	32	Infectious	infectious	JJ
cord-018089-m94q75xn	261	33	entry	entry	NN
cord-018089-m94q75xn	261	34	pathway	pathway	NN
cord-018089-m94q75xn	261	35	of	of	IN
cord-018089-m94q75xn	261	36	influenza	influenza	NN
cord-018089-m94q75xn	261	37	virus	virus	NN
cord-018089-m94q75xn	261	38	in	in	IN
cord-018089-m94q75xn	261	39	a	a	DT
cord-018089-m94q75xn	261	40	canine	canine	JJ
cord-018089-m94q75xn	261	41	kidney	kidney	NN
cord-018089-m94q75xn	261	42	cell	cell	NN
cord-018089-m94q75xn	261	43	line	line	NN
cord-018089-m94q75xn	261	44	Caveolae	Caveolae	NNP
cord-018089-m94q75xn	261	45	as	as	IN
cord-018089-m94q75xn	261	46	an	an	DT
cord-018089-m94q75xn	261	47	additional	additional	JJ
cord-018089-m94q75xn	261	48	route	route	NN
cord-018089-m94q75xn	261	49	for	for	IN
cord-018089-m94q75xn	261	50	influenza	influenza	NN
cord-018089-m94q75xn	261	51	virus	virus	NN
cord-018089-m94q75xn	261	52	endocytosis	endocytosis	NN
cord-018089-m94q75xn	261	53	in	in	IN
cord-018089-m94q75xn	261	54	MDCK	MDCK	NNP
cord-018089-m94q75xn	261	55	cells	cell	VBZ
cord-018089-m94q75xn	261	56	Evidence	evidence	NN
cord-018089-m94q75xn	261	57	for	for	IN
cord-018089-m94q75xn	261	58	segment	segment	NN
cord-018089-m94q75xn	261	59	-	-	HYPH
cord-018089-m94q75xn	261	60	nonspecific	nonspecific	JJ
cord-018089-m94q75xn	261	61	packaging	packaging	NN
cord-018089-m94q75xn	261	62	of	of	IN
cord-018089-m94q75xn	261	63	the	the	DT
cord-018089-m94q75xn	261	64	influenza	influenza	NN
cord-018089-m94q75xn	261	65	a	a	DT
cord-018089-m94q75xn	261	66	virus	virus	NN
cord-018089-m94q75xn	261	67	genome	genome	NN
cord-018089-m94q75xn	261	68	Exploitation	exploitation	NN
cord-018089-m94q75xn	261	69	of	of	IN
cord-018089-m94q75xn	261	70	nucleic	nucleic	JJ
cord-018089-m94q75xn	261	71	acid	acid	NN
cord-018089-m94q75xn	261	72	packaging	packaging	NN
cord-018089-m94q75xn	261	73	signals	signal	NNS
cord-018089-m94q75xn	261	74	to	to	TO
cord-018089-m94q75xn	261	75	generate	generate	VB
cord-018089-m94q75xn	261	76	a	a	DT
cord-018089-m94q75xn	261	77	novel	novel	JJ
cord-018089-m94q75xn	261	78	influenza	influenza	NN
cord-018089-m94q75xn	261	79	virus	virus	NN
cord-018089-m94q75xn	261	80	-	-	HYPH
cord-018089-m94q75xn	261	81	based	base	VBN
cord-018089-m94q75xn	261	82	vector	vector	NN
cord-018089-m94q75xn	261	83	stably	stably	RB
cord-018089-m94q75xn	261	84	expressing	express	VBG
cord-018089-m94q75xn	261	85	two	two	CD
cord-018089-m94q75xn	261	86	foreign	foreign	JJ
cord-018089-m94q75xn	261	87	genes	gene	NNS
cord-018089-m94q75xn	261	88	Evidence	evidence	NN
cord-018089-m94q75xn	261	89	for	for	IN
cord-018089-m94q75xn	261	90	specific	specific	JJ
cord-018089-m94q75xn	261	91	packaging	packaging	NN
cord-018089-m94q75xn	261	92	of	of	IN
cord-018089-m94q75xn	261	93	the	the	DT
cord-018089-m94q75xn	261	94	influenza	influenza	NN
cord-018089-m94q75xn	261	95	A	a	DT
cord-018089-m94q75xn	261	96	virus	virus	NN
cord-018089-m94q75xn	261	97	genome	genome	NN
cord-018089-m94q75xn	261	98	from	from	IN
cord-018089-m94q75xn	261	99	conditionally	conditionally	RB
cord-018089-m94q75xn	261	100	defective	defective	JJ
cord-018089-m94q75xn	261	101	virus	virus	NN
cord-018089-m94q75xn	261	102	particles	particle	NNS
cord-018089-m94q75xn	261	103	lacking	lack	VBG
cord-018089-m94q75xn	261	104	a	a	DT
cord-018089-m94q75xn	261	105	polymerase	polymerase	NN
cord-018089-m94q75xn	261	106	gene	gene	NN
cord-018089-m94q75xn	261	107	Importance	importance	NN
cord-018089-m94q75xn	261	108	of	of	IN
cord-018089-m94q75xn	261	109	both	both	CC
cord-018089-m94q75xn	261	110	the	the	DT
cord-018089-m94q75xn	261	111	coding	coding	NN
cord-018089-m94q75xn	261	112	and	and	CC
cord-018089-m94q75xn	261	113	the	the	DT
cord-018089-m94q75xn	261	114	segment	segment	NN
cord-018089-m94q75xn	261	115	-	-	HYPH
cord-018089-m94q75xn	261	116	specific	specific	JJ
cord-018089-m94q75xn	261	117	noncoding	noncoding	JJ
cord-018089-m94q75xn	261	118	regions	region	NNS
cord-018089-m94q75xn	261	119	of	of	IN
cord-018089-m94q75xn	261	120	the	the	DT
cord-018089-m94q75xn	261	121	influenza	influenza	NN
cord-018089-m94q75xn	261	122	A	a	DT
cord-018089-m94q75xn	261	123	virus	virus	NN
cord-018089-m94q75xn	261	124	NS	NS	NNP
cord-018089-m94q75xn	261	125	segment	segment	NN
cord-018089-m94q75xn	261	126	for	for	IN
cord-018089-m94q75xn	261	127	its	-PRON-	PRP$
cord-018089-m94q75xn	261	128	efficient	efficient	JJ
cord-018089-m94q75xn	261	129	incorporation	incorporation	NN
cord-018089-m94q75xn	261	130	into	into	IN
cord-018089-m94q75xn	261	131	virions	virion	NNS
cord-018089-m94q75xn	261	132	Cis	Cis	NNP
cord-018089-m94q75xn	261	133	-	-	HYPH
cord-018089-m94q75xn	261	134	acting	act	VBG
cord-018089-m94q75xn	261	135	packaging	packaging	NN
cord-018089-m94q75xn	261	136	signals	signal	NNS
cord-018089-m94q75xn	261	137	in	in	IN
cord-018089-m94q75xn	261	138	the	the	DT
cord-018089-m94q75xn	261	139	influenza	influenza	NN
cord-018089-m94q75xn	261	140	virus	virus	NN
cord-018089-m94q75xn	261	141	PB1	PB1	NNP
cord-018089-m94q75xn	261	142	,	,	,
cord-018089-m94q75xn	261	143	PB2	PB2	NNP
cord-018089-m94q75xn	261	144	,	,	,
cord-018089-m94q75xn	261	145	and	and	CC
cord-018089-m94q75xn	261	146	PA	PA	NNP
cord-018089-m94q75xn	261	147	genomic	genomic	JJ
cord-018089-m94q75xn	261	148	RNA	RNA	NNP
cord-018089-m94q75xn	261	149	segments	segment	NNS
cord-018089-m94q75xn	262	1	Selective	selective	JJ
cord-018089-m94q75xn	262	2	incorporation	incorporation	NN
cord-018089-m94q75xn	262	3	of	of	IN
cord-018089-m94q75xn	262	4	influenza	influenza	NN
cord-018089-m94q75xn	262	5	virus	virus	NN
cord-018089-m94q75xn	262	6	RNA	RNA	NNP
cord-018089-m94q75xn	262	7	segments	segment	NNS
cord-018089-m94q75xn	262	8	into	into	IN
cord-018089-m94q75xn	262	9	virions	virion	NNS
cord-018089-m94q75xn	262	10	Codon	Codon	NNP
cord-018089-m94q75xn	262	11	conservation	conservation	NN
cord-018089-m94q75xn	262	12	in	in	IN
cord-018089-m94q75xn	262	13	the	the	DT
cord-018089-m94q75xn	262	14	influenza	influenza	NN
cord-018089-m94q75xn	262	15	A	a	DT
cord-018089-m94q75xn	262	16	virus	virus	NN
cord-018089-m94q75xn	262	17	genome	genome	NN
cord-018089-m94q75xn	262	18	defines	define	VBZ
cord-018089-m94q75xn	262	19	RNA	RNA	NNP
cord-018089-m94q75xn	262	20	packaging	packaging	NN
cord-018089-m94q75xn	262	21	signals	signal	NNS
cord-018089-m94q75xn	262	22	Influenza	Influenza	NNP
cord-018089-m94q75xn	262	23	virus	virus	NN
cord-018089-m94q75xn	262	24	assembly	assembly	NN
cord-018089-m94q75xn	262	25	and	and	CC
cord-018089-m94q75xn	262	26	budding	bud	VBG
cord-018089-m94q75xn	262	27	at	at	IN
cord-018089-m94q75xn	262	28	the	the	DT
cord-018089-m94q75xn	262	29	viral	viral	JJ
cord-018089-m94q75xn	262	30	budozone	budozone	NNP
cord-018089-m94q75xn	262	31	Influenza	Influenza	NNP
cord-018089-m94q75xn	262	32	virus	virus	NN
cord-018089-m94q75xn	262	33	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	262	34	(	(	-LRB-
cord-018089-m94q75xn	262	35	H3	H3	NNP
cord-018089-m94q75xn	262	36	subtype	subtype	NN
cord-018089-m94q75xn	262	37	)	)	-RRB-
cord-018089-m94q75xn	262	38	requires	require	VBZ
cord-018089-m94q75xn	262	39	palmitoylation	palmitoylation	NN
cord-018089-m94q75xn	262	40	of	of	IN
cord-018089-m94q75xn	262	41	its	-PRON-	PRP$
cord-018089-m94q75xn	262	42	cytoplasmic	cytoplasmic	JJ
cord-018089-m94q75xn	262	43	tail	tail	NN
cord-018089-m94q75xn	262	44	for	for	IN
cord-018089-m94q75xn	262	45	assembly	assembly	NN
cord-018089-m94q75xn	262	46	:	:	:
cord-018089-m94q75xn	262	47	M1	M1	NNP
cord-018089-m94q75xn	262	48	proteins	protein	NNS
cord-018089-m94q75xn	262	49	of	of	IN
cord-018089-m94q75xn	262	50	two	two	CD
cord-018089-m94q75xn	262	51	subtypes	subtype	NNS
cord-018089-m94q75xn	262	52	differ	differ	VBP
cord-018089-m94q75xn	262	53	in	in	IN
cord-018089-m94q75xn	262	54	their	-PRON-	PRP$
cord-018089-m94q75xn	262	55	ability	ability	NN
cord-018089-m94q75xn	262	56	to	to	TO
cord-018089-m94q75xn	262	57	support	support	VB
cord-018089-m94q75xn	262	58	assembly	assembly	NNP
cord-018089-m94q75xn	262	59	Influenza	Influenza	NNP
cord-018089-m94q75xn	262	60	virus	virus	NN
cord-018089-m94q75xn	262	61	assembly	assembly	NN
cord-018089-m94q75xn	262	62	and	and	CC
cord-018089-m94q75xn	262	63	lipid	lipid	JJ
cord-018089-m94q75xn	262	64	raft	raft	NN
cord-018089-m94q75xn	262	65	microdomains	microdomain	NNS
cord-018089-m94q75xn	262	66	:	:	:
cord-018089-m94q75xn	262	67	a	a	DT
cord-018089-m94q75xn	262	68	role	role	NN
cord-018089-m94q75xn	262	69	for	for	IN
cord-018089-m94q75xn	262	70	the	the	DT
cord-018089-m94q75xn	262	71	cytoplasmic	cytoplasmic	JJ
cord-018089-m94q75xn	262	72	tails	tail	NNS
cord-018089-m94q75xn	262	73	of	of	IN
cord-018089-m94q75xn	262	74	the	the	DT
cord-018089-m94q75xn	262	75	spike	spike	NN
cord-018089-m94q75xn	262	76	glycoproteins	glycoprotein	NNS
cord-018089-m94q75xn	262	77	Role	role	NN
cord-018089-m94q75xn	262	78	of	of	IN
cord-018089-m94q75xn	262	79	transmembrane	transmembrane	NN
cord-018089-m94q75xn	262	80	domain	domain	NN
cord-018089-m94q75xn	262	81	and	and	CC
cord-018089-m94q75xn	262	82	cytoplasmic	cytoplasmic	JJ
cord-018089-m94q75xn	262	83	tail	tail	NN
cord-018089-m94q75xn	262	84	amino	amino	NN
cord-018089-m94q75xn	262	85	acid	acid	NN
cord-018089-m94q75xn	262	86	sequences	sequence	NNS
cord-018089-m94q75xn	262	87	of	of	IN
cord-018089-m94q75xn	262	88	influenza	influenza	NN
cord-018089-m94q75xn	263	1	a	a	DT
cord-018089-m94q75xn	263	2	virus	virus	NN
cord-018089-m94q75xn	263	3	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	263	4	in	in	IN
cord-018089-m94q75xn	263	5	raft	raft	NNP
cord-018089-m94q75xn	263	6	association	association	NN
cord-018089-m94q75xn	263	7	and	and	CC
cord-018089-m94q75xn	263	8	virus	virus	NN
cord-018089-m94q75xn	263	9	budding	bud	VBG
cord-018089-m94q75xn	263	10	Lipid	lipid	JJ
cord-018089-m94q75xn	263	11	raft	raft	NN
cord-018089-m94q75xn	263	12	-	-	HYPH
cord-018089-m94q75xn	263	13	dependent	dependent	JJ
cord-018089-m94q75xn	263	14	targeting	targeting	NN
cord-018089-m94q75xn	263	15	of	of	IN
cord-018089-m94q75xn	263	16	the	the	DT
cord-018089-m94q75xn	263	17	influenza	influenza	NN
cord-018089-m94q75xn	263	18	A	a	DT
cord-018089-m94q75xn	263	19	virus	virus	NN
cord-018089-m94q75xn	263	20	nucleoprotein	nucleoprotein	NN
cord-018089-m94q75xn	263	21	to	to	IN
cord-018089-m94q75xn	263	22	the	the	DT
cord-018089-m94q75xn	263	23	apical	apical	JJ
cord-018089-m94q75xn	263	24	plasma	plasma	NN
cord-018089-m94q75xn	263	25	membrane	membrane	NN
cord-018089-m94q75xn	263	26	Reverse	Reverse	NNP
cord-018089-m94q75xn	263	27	genetics	genetics	NN
cord-018089-m94q75xn	263	28	studies	study	NNS
cord-018089-m94q75xn	263	29	on	on	IN
cord-018089-m94q75xn	263	30	the	the	DT
cord-018089-m94q75xn	263	31	filamentous	filamentous	JJ
cord-018089-m94q75xn	263	32	morphology	morphology	NN
cord-018089-m94q75xn	263	33	of	of	IN
cord-018089-m94q75xn	263	34	influenza	influenza	NN
cord-018089-m94q75xn	263	35	A	a	DT
cord-018089-m94q75xn	263	36	virus	virus	NN
cord-018089-m94q75xn	264	1	The	the	DT
cord-018089-m94q75xn	264	2	M1	M1	NNP
cord-018089-m94q75xn	264	3	matrix	matrix	NN
cord-018089-m94q75xn	264	4	protein	protein	NN
cord-018089-m94q75xn	264	5	controls	control	VBZ
cord-018089-m94q75xn	264	6	the	the	DT
cord-018089-m94q75xn	264	7	filamentous	filamentous	JJ
cord-018089-m94q75xn	264	8	phenotype	phenotype	NN
cord-018089-m94q75xn	264	9	of	of	IN
cord-018089-m94q75xn	264	10	influenza	influenza	NN
cord-018089-m94q75xn	264	11	A	a	DT
cord-018089-m94q75xn	264	12	virus	virus	NN
cord-018089-m94q75xn	264	13	Characterization	characterization	NN
cord-018089-m94q75xn	264	14	of	of	IN
cord-018089-m94q75xn	264	15	temperature	temperature	NN
cord-018089-m94q75xn	264	16	sensitive	sensitive	JJ
cord-018089-m94q75xn	264	17	influenza	influenza	NN
cord-018089-m94q75xn	264	18	virus	virus	NN
cord-018089-m94q75xn	264	19	mutants	mutant	NNS
cord-018089-m94q75xn	264	20	defective	defective	JJ
cord-018089-m94q75xn	264	21	in	in	IN
cord-018089-m94q75xn	264	22	neuraminidase	neuraminidase	JJ
cord-018089-m94q75xn	264	23	Balanced	balanced	JJ
cord-018089-m94q75xn	264	24	hemagglutinin	hemagglutinin	NNS
cord-018089-m94q75xn	264	25	and	and	CC
cord-018089-m94q75xn	264	26	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	264	27	activities	activity	NNS
cord-018089-m94q75xn	264	28	are	be	VBP
cord-018089-m94q75xn	264	29	critical	critical	JJ
cord-018089-m94q75xn	264	30	for	for	IN
cord-018089-m94q75xn	264	31	efficient	efficient	JJ
cord-018089-m94q75xn	264	32	replication	replication	NN
cord-018089-m94q75xn	264	33	of	of	IN
cord-018089-m94q75xn	264	34	influenza	influenza	NN
cord-018089-m94q75xn	264	35	A	a	DT
cord-018089-m94q75xn	264	36	virus	virus	NN
cord-018089-m94q75xn	264	37	Influenza	Influenza	NNP
cord-018089-m94q75xn	264	38	virus	virus	NN
cord-018089-m94q75xn	264	39	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	264	40	:	:	:
cord-018089-m94q75xn	264	41	structure	structure	NN
cord-018089-m94q75xn	264	42	,	,	,
cord-018089-m94q75xn	264	43	antibodies	antibody	NNS
cord-018089-m94q75xn	264	44	,	,	,
cord-018089-m94q75xn	264	45	and	and	CC
cord-018089-m94q75xn	264	46	inhibitors	inhibitor	NNS
cord-018089-m94q75xn	265	1	Positive	positive	JJ
cord-018089-m94q75xn	265	2	Darwinian	darwinian	JJ
cord-018089-m94q75xn	265	3	evolution	evolution	NN
cord-018089-m94q75xn	265	4	in	in	IN
cord-018089-m94q75xn	265	5	human	human	JJ
cord-018089-m94q75xn	265	6	influenza	influenza	NN
cord-018089-m94q75xn	265	7	A	a	DT
cord-018089-m94q75xn	265	8	viruses	virus	NNS
cord-018089-m94q75xn	265	9	Mapping	map	VBG
cord-018089-m94q75xn	265	10	the	the	DT
cord-018089-m94q75xn	265	11	antigenic	antigenic	JJ
cord-018089-m94q75xn	265	12	and	and	CC
cord-018089-m94q75xn	265	13	genetic	genetic	JJ
cord-018089-m94q75xn	265	14	evolution	evolution	NN
cord-018089-m94q75xn	265	15	of	of	IN
cord-018089-m94q75xn	265	16	influenza	influenza	NN
cord-018089-m94q75xn	265	17	virus	virus	NN
cord-018089-m94q75xn	265	18	Influenza	influenza	NN
cord-018089-m94q75xn	265	19	:	:	:
cord-018089-m94q75xn	265	20	lessons	lesson	NNS
cord-018089-m94q75xn	265	21	from	from	IN
cord-018089-m94q75xn	265	22	past	past	JJ
cord-018089-m94q75xn	265	23	pandemics	pandemic	NNS
cord-018089-m94q75xn	265	24	,	,	,
cord-018089-m94q75xn	265	25	warnings	warning	NNS
cord-018089-m94q75xn	265	26	from	from	IN
cord-018089-m94q75xn	265	27	current	current	JJ
cord-018089-m94q75xn	265	28	incidents	incident	NNS
cord-018089-m94q75xn	265	29	Probable	probable	JJ
cord-018089-m94q75xn	265	30	limited	limited	JJ
cord-018089-m94q75xn	265	31	person	person	NN
cord-018089-m94q75xn	265	32	-	-	HYPH
cord-018089-m94q75xn	265	33	to	to	IN
cord-018089-m94q75xn	265	34	-	-	HYPH
cord-018089-m94q75xn	265	35	person	person	NN
cord-018089-m94q75xn	265	36	transmission	transmission	NN
cord-018089-m94q75xn	265	37	of	of	IN
cord-018089-m94q75xn	265	38	highly	highly	RB
cord-018089-m94q75xn	265	39	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	265	40	avian	avian	JJ
cord-018089-m94q75xn	265	41	influenza	influenza	NN
cord-018089-m94q75xn	265	42	A	a	NN
cord-018089-m94q75xn	265	43	(	(	-LRB-
cord-018089-m94q75xn	265	44	H5N1	H5N1	NNP
cord-018089-m94q75xn	265	45	)	)	-RRB-
cord-018089-m94q75xn	265	46	virus	virus	NN
cord-018089-m94q75xn	265	47	in	in	IN
cord-018089-m94q75xn	265	48	China	China	NNP
cord-018089-m94q75xn	265	49	H5N1	H5N1	NNP
cord-018089-m94q75xn	265	50	influenza	influenza	NN
cord-018089-m94q75xn	265	51	-	-	:
cord-018089-m94q75xn	265	52	continuing	continue	VBG
cord-018089-m94q75xn	265	53	evolution	evolution	NN
cord-018089-m94q75xn	265	54	and	and	CC
cord-018089-m94q75xn	265	55	spread	spread	VBD
cord-018089-m94q75xn	265	56	Global	global	JJ
cord-018089-m94q75xn	265	57	epidemiology	epidemiology	NN
cord-018089-m94q75xn	265	58	of	of	IN
cord-018089-m94q75xn	265	59	human	human	JJ
cord-018089-m94q75xn	265	60	infections	infection	NNS
cord-018089-m94q75xn	265	61	with	with	IN
cord-018089-m94q75xn	265	62	highly	highly	RB
cord-018089-m94q75xn	265	63	pathogenic	pathogenic	JJ
cord-018089-m94q75xn	265	64	avian	avian	JJ
cord-018089-m94q75xn	265	65	influenza	influenza	NN
cord-018089-m94q75xn	265	66	A	a	NN
cord-018089-m94q75xn	265	67	(	(	-LRB-
cord-018089-m94q75xn	265	68	H5N1	H5N1	NNP
cord-018089-m94q75xn	265	69	)	)	-RRB-
cord-018089-m94q75xn	265	70	viruses	viruse	VBZ
cord-018089-m94q75xn	265	71	Emergence	emergence	NN
cord-018089-m94q75xn	265	72	of	of	IN
cord-018089-m94q75xn	265	73	a	a	DT
cord-018089-m94q75xn	265	74	novel	novel	JJ
cord-018089-m94q75xn	265	75	swine	swine	NN
cord-018089-m94q75xn	265	76	-	-	HYPH
cord-018089-m94q75xn	265	77	origin	origin	NN
cord-018089-m94q75xn	265	78	influenza	influenza	NN
cord-018089-m94q75xn	265	79	A	A	NNP
cord-018089-m94q75xn	265	80	(	(	-LRB-
cord-018089-m94q75xn	265	81	H1N1	H1N1	NNP
cord-018089-m94q75xn	265	82	)	)	-RRB-
cord-018089-m94q75xn	265	83	virus	virus	NN
cord-018089-m94q75xn	265	84	in	in	IN
cord-018089-m94q75xn	265	85	humans	human	NNS
cord-018089-m94q75xn	265	86	Evolution	Evolution	NNP
cord-018089-m94q75xn	265	87	of	of	IN
cord-018089-m94q75xn	265	88	the	the	DT
cord-018089-m94q75xn	265	89	H3	H3	NNP
cord-018089-m94q75xn	265	90	influenza	influenza	NN
cord-018089-m94q75xn	265	91	virus	virus	NN
cord-018089-m94q75xn	265	92	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	265	93	from	from	IN
cord-018089-m94q75xn	265	94	human	human	JJ
cord-018089-m94q75xn	265	95	and	and	CC
cord-018089-m94q75xn	265	96	nonhuman	nonhuman	NN
cord-018089-m94q75xn	265	97	hosts	host	NNS
cord-018089-m94q75xn	265	98	Ecological	ecological	JJ
cord-018089-m94q75xn	265	99	and	and	CC
cord-018089-m94q75xn	265	100	immunological	immunological	JJ
cord-018089-m94q75xn	265	101	determinants	determinant	NNS
cord-018089-m94q75xn	265	102	of	of	IN
cord-018089-m94q75xn	265	103	influenza	influenza	NN
cord-018089-m94q75xn	265	104	evolution	evolution	NN
cord-018089-m94q75xn	265	105	Hemagglutinin	Hemagglutinin	NNP
cord-018089-m94q75xn	265	106	sequence	sequence	NN
cord-018089-m94q75xn	265	107	clusters	cluster	NNS
cord-018089-m94q75xn	265	108	and	and	CC
cord-018089-m94q75xn	265	109	the	the	DT
cord-018089-m94q75xn	265	110	antigenic	antigenic	JJ
cord-018089-m94q75xn	265	111	evolution	evolution	NN
cord-018089-m94q75xn	265	112	of	of	IN
cord-018089-m94q75xn	265	113	influenza	influenza	NN
cord-018089-m94q75xn	265	114	A	a	DT
cord-018089-m94q75xn	265	115	virus	virus	NN
cord-018089-m94q75xn	265	116	Sialic	sialic	NN
cord-018089-m94q75xn	265	117	acid	acid	NN
cord-018089-m94q75xn	265	118	species	specie	NNS
cord-018089-m94q75xn	265	119	as	as	IN
cord-018089-m94q75xn	265	120	a	a	DT
cord-018089-m94q75xn	265	121	determinant	determinant	NN
cord-018089-m94q75xn	265	122	of	of	IN
cord-018089-m94q75xn	265	123	the	the	DT
cord-018089-m94q75xn	265	124	host	host	NN
cord-018089-m94q75xn	265	125	range	range	NN
cord-018089-m94q75xn	265	126	of	of	IN
cord-018089-m94q75xn	265	127	influenza	influenza	NN
cord-018089-m94q75xn	265	128	A	a	DT
cord-018089-m94q75xn	265	129	viruses	virus	NNS
cord-018089-m94q75xn	266	1	The	the	DT
cord-018089-m94q75xn	266	2	role	role	NN
cord-018089-m94q75xn	266	3	of	of	IN
cord-018089-m94q75xn	266	4	influenza	influenza	NN
cord-018089-m94q75xn	266	5	A	a	DT
cord-018089-m94q75xn	266	6	virus	virus	NN
cord-018089-m94q75xn	266	7	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	266	8	residues	residue	VBZ
cord-018089-m94q75xn	266	9	226	226	CD
cord-018089-m94q75xn	266	10	and	and	CC
cord-018089-m94q75xn	266	11	228	228	CD
cord-018089-m94q75xn	266	12	in	in	IN
cord-018089-m94q75xn	266	13	receptor	receptor	NN
cord-018089-m94q75xn	266	14	specificity	specificity	NN
cord-018089-m94q75xn	266	15	and	and	CC
cord-018089-m94q75xn	266	16	host	host	NN
cord-018089-m94q75xn	266	17	range	range	NN
cord-018089-m94q75xn	266	18	restriction	restriction	NN
cord-018089-m94q75xn	266	19	Receptor	receptor	NN
cord-018089-m94q75xn	266	20	binding	bind	VBG
cord-018089-m94q75xn	266	21	properties	property	NNS
cord-018089-m94q75xn	266	22	of	of	IN
cord-018089-m94q75xn	266	23	human	human	JJ
cord-018089-m94q75xn	266	24	and	and	CC
cord-018089-m94q75xn	266	25	animal	animal	NN
cord-018089-m94q75xn	266	26	H1	H1	NNP
cord-018089-m94q75xn	266	27	influenza	influenza	NN
cord-018089-m94q75xn	266	28	virus	virus	NN
cord-018089-m94q75xn	266	29	isolates	isolate	VBZ
cord-018089-m94q75xn	266	30	Receptor	Receptor	NNP
cord-018089-m94q75xn	266	31	determinants	determinant	NNS
cord-018089-m94q75xn	266	32	of	of	IN
cord-018089-m94q75xn	266	33	human	human	JJ
cord-018089-m94q75xn	266	34	and	and	CC
cord-018089-m94q75xn	266	35	animal	animal	NN
cord-018089-m94q75xn	266	36	influenza	influenza	NN
cord-018089-m94q75xn	266	37	virus	virus	NN
cord-018089-m94q75xn	266	38	isolates	isolate	VBZ
cord-018089-m94q75xn	266	39	:	:	:
cord-018089-m94q75xn	266	40	differences	difference	NNS
cord-018089-m94q75xn	266	41	in	in	IN
cord-018089-m94q75xn	266	42	receptor	receptor	NN
cord-018089-m94q75xn	266	43	specificity	specificity	NN
cord-018089-m94q75xn	266	44	of	of	IN
cord-018089-m94q75xn	266	45	the	the	DT
cord-018089-m94q75xn	266	46	H3	H3	NNP
cord-018089-m94q75xn	266	47	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	266	48	based	base	VBN
cord-018089-m94q75xn	266	49	on	on	IN
cord-018089-m94q75xn	266	50	species	specie	NNS
cord-018089-m94q75xn	266	51	of	of	IN
cord-018089-m94q75xn	266	52	origin	origin	NN
cord-018089-m94q75xn	266	53	Differential	differential	JJ
cord-018089-m94q75xn	266	54	sensitivity	sensitivity	NN
cord-018089-m94q75xn	266	55	of	of	IN
cord-018089-m94q75xn	266	56	human	human	NN
cord-018089-m94q75xn	266	57	,	,	,
cord-018089-m94q75xn	266	58	avian	avian	JJ
cord-018089-m94q75xn	266	59	,	,	,
cord-018089-m94q75xn	266	60	and	and	CC
cord-018089-m94q75xn	266	61	equine	equine	NN
cord-018089-m94q75xn	266	62	influenza	influenza	NN
cord-018089-m94q75xn	266	63	A	a	DT
cord-018089-m94q75xn	266	64	viruses	virus	NNS
cord-018089-m94q75xn	266	65	to	to	IN
cord-018089-m94q75xn	266	66	a	a	DT
cord-018089-m94q75xn	266	67	glycoprotein	glycoprotein	NN
cord-018089-m94q75xn	266	68	inhibitor	inhibitor	NN
cord-018089-m94q75xn	266	69	of	of	IN
cord-018089-m94q75xn	266	70	infection	infection	NN
cord-018089-m94q75xn	266	71	:	:	:
cord-018089-m94q75xn	266	72	selection	selection	NN
cord-018089-m94q75xn	266	73	of	of	IN
cord-018089-m94q75xn	266	74	receptor	receptor	NN
cord-018089-m94q75xn	266	75	specific	specific	JJ
cord-018089-m94q75xn	266	76	variants	variant	NNS
cord-018089-m94q75xn	266	77	Infection	infection	NN
cord-018089-m94q75xn	266	78	of	of	IN
cord-018089-m94q75xn	266	79	human	human	JJ
cord-018089-m94q75xn	266	80	airway	airway	NN
cord-018089-m94q75xn	266	81	epithelium	epithelium	NN
cord-018089-m94q75xn	266	82	by	by	IN
cord-018089-m94q75xn	266	83	human	human	JJ
cord-018089-m94q75xn	266	84	and	and	CC
cord-018089-m94q75xn	266	85	avian	avian	JJ
cord-018089-m94q75xn	266	86	strains	strain	NNS
cord-018089-m94q75xn	266	87	of	of	IN
cord-018089-m94q75xn	266	88	influenza	influenza	NN
cord-018089-m94q75xn	266	89	a	a	DT
cord-018089-m94q75xn	266	90	virus	virus	NN
cord-018089-m94q75xn	266	91	Human	human	JJ
cord-018089-m94q75xn	266	92	and	and	CC
cord-018089-m94q75xn	266	93	avian	avian	JJ
cord-018089-m94q75xn	266	94	influenza	influenza	NN
cord-018089-m94q75xn	266	95	viruses	virus	NNS
cord-018089-m94q75xn	266	96	target	target	VBP
cord-018089-m94q75xn	266	97	different	different	JJ
cord-018089-m94q75xn	266	98	cell	cell	NN
cord-018089-m94q75xn	266	99	types	type	NNS
cord-018089-m94q75xn	266	100	in	in	IN
cord-018089-m94q75xn	266	101	cultures	culture	NNS
cord-018089-m94q75xn	266	102	of	of	IN
cord-018089-m94q75xn	266	103	human	human	JJ
cord-018089-m94q75xn	266	104	airway	airway	NN
cord-018089-m94q75xn	266	105	epithelium	epithelium	NN
cord-018089-m94q75xn	266	106	Avian	avian	JJ
cord-018089-m94q75xn	266	107	flu	flu	NN
cord-018089-m94q75xn	266	108	:	:	:
cord-018089-m94q75xn	267	1	influenza	influenza	NN
cord-018089-m94q75xn	267	2	virus	virus	NN
cord-018089-m94q75xn	267	3	receptors	receptor	NNS
cord-018089-m94q75xn	267	4	in	in	IN
cord-018089-m94q75xn	267	5	the	the	DT
cord-018089-m94q75xn	267	6	human	human	JJ
cord-018089-m94q75xn	267	7	airway	airway	NN
cord-018089-m94q75xn	267	8	Influenza	Influenza	NNP
cord-018089-m94q75xn	267	9	virus	virus	NN
cord-018089-m94q75xn	267	10	receptor	receptor	NN
cord-018089-m94q75xn	267	11	specificity	specificity	NN
cord-018089-m94q75xn	267	12	and	and	CC
cord-018089-m94q75xn	267	13	cell	cell	NN
cord-018089-m94q75xn	267	14	tropism	tropism	NN
cord-018089-m94q75xn	267	15	in	in	IN
cord-018089-m94q75xn	267	16	mouse	mouse	NN
cord-018089-m94q75xn	267	17	and	and	CC
cord-018089-m94q75xn	267	18	human	human	JJ
cord-018089-m94q75xn	267	19	airway	airway	NN
cord-018089-m94q75xn	267	20	epithelial	epithelial	NN
cord-018089-m94q75xn	267	21	cells	cell	NNS
cord-018089-m94q75xn	267	22	H5N1	H5N1	NNP
cord-018089-m94q75xn	267	23	virus	virus	NN
cord-018089-m94q75xn	267	24	attachment	attachment	NN
cord-018089-m94q75xn	267	25	to	to	TO
cord-018089-m94q75xn	267	26	lower	lower	VB
cord-018089-m94q75xn	267	27	respiratory	respiratory	JJ
cord-018089-m94q75xn	267	28	tract	tract	NN
cord-018089-m94q75xn	267	29	Fatal	fatal	JJ
cord-018089-m94q75xn	267	30	outcome	outcome	NN
cord-018089-m94q75xn	267	31	of	of	IN
cord-018089-m94q75xn	267	32	human	human	JJ
cord-018089-m94q75xn	267	33	influenza	influenza	NN
cord-018089-m94q75xn	267	34	A	a	NN
cord-018089-m94q75xn	267	35	(	(	-LRB-
cord-018089-m94q75xn	267	36	H5N1	H5N1	NNP
cord-018089-m94q75xn	267	37	)	)	-RRB-
cord-018089-m94q75xn	267	38	is	be	VBZ
cord-018089-m94q75xn	267	39	associated	associate	VBN
cord-018089-m94q75xn	267	40	with	with	IN
cord-018089-m94q75xn	267	41	high	high	JJ
cord-018089-m94q75xn	267	42	viral	viral	JJ
cord-018089-m94q75xn	267	43	load	load	NN
cord-018089-m94q75xn	267	44	and	and	CC
cord-018089-m94q75xn	267	45	hypercytokinemia	hypercytokinemia	NN
cord-018089-m94q75xn	267	46	Three	three	CD
cord-018089-m94q75xn	267	47	Indonesian	indonesian	JJ
cord-018089-m94q75xn	267	48	clusters	cluster	NNS
cord-018089-m94q75xn	267	49	of	of	IN
cord-018089-m94q75xn	267	50	H5N1	H5N1	NNP
cord-018089-m94q75xn	267	51	virus	virus	NN
cord-018089-m94q75xn	267	52	infection	infection	NN
cord-018089-m94q75xn	267	53	in	in	IN
cord-018089-m94q75xn	267	54	2005	2005	CD
cord-018089-m94q75xn	268	1	Avian	avian	JJ
cord-018089-m94q75xn	268	2	influenza	influenza	NN
cord-018089-m94q75xn	268	3	A	a	NN
cord-018089-m94q75xn	268	4	(	(	-LRB-
cord-018089-m94q75xn	268	5	H5N1	H5N1	NNP
cord-018089-m94q75xn	268	6	)	)	-RRB-
cord-018089-m94q75xn	268	7	infection	infection	NN
cord-018089-m94q75xn	268	8	in	in	IN
cord-018089-m94q75xn	268	9	eastern	eastern	JJ
cord-018089-m94q75xn	268	10	Turkey	Turkey	NNP
cord-018089-m94q75xn	268	11	in	in	IN
cord-018089-m94q75xn	268	12	2006	2006	CD
cord-018089-m94q75xn	268	13	Human	human	JJ
cord-018089-m94q75xn	268	14	infection	infection	NN
cord-018089-m94q75xn	268	15	with	with	IN
cord-018089-m94q75xn	268	16	an	an	DT
cord-018089-m94q75xn	268	17	avian	avian	JJ
cord-018089-m94q75xn	268	18	H9N2	H9N2	NNP
cord-018089-m94q75xn	268	19	influenza	influenza	NN
cord-018089-m94q75xn	268	20	A	a	DT
cord-018089-m94q75xn	268	21	virus	virus	NN
cord-018089-m94q75xn	268	22	in	in	IN
cord-018089-m94q75xn	268	23	Hong	Hong	NNP
cord-018089-m94q75xn	268	24	Kong	Kong	NNP
cord-018089-m94q75xn	268	25	in	in	IN
cord-018089-m94q75xn	268	26	2003	2003	CD
cord-018089-m94q75xn	268	27	Transmission	Transmission	NNP
cord-018089-m94q75xn	268	28	of	of	IN
cord-018089-m94q75xn	268	29	H7N7	H7N7	NNP
cord-018089-m94q75xn	269	1	avian	avian	JJ
cord-018089-m94q75xn	269	2	influenza	influenza	NN
cord-018089-m94q75xn	269	3	A	a	DT
cord-018089-m94q75xn	269	4	virus	virus	NN
cord-018089-m94q75xn	269	5	to	to	IN
cord-018089-m94q75xn	269	6	human	human	JJ
cord-018089-m94q75xn	269	7	beings	being	NNS
cord-018089-m94q75xn	269	8	during	during	IN
cord-018089-m94q75xn	269	9	a	a	DT
cord-018089-m94q75xn	269	10	large	large	JJ
cord-018089-m94q75xn	269	11	outbreak	outbreak	NN
cord-018089-m94q75xn	269	12	in	in	IN
cord-018089-m94q75xn	269	13	commercial	commercial	JJ
cord-018089-m94q75xn	269	14	poultry	poultry	NN
cord-018089-m94q75xn	269	15	farms	farm	NNS
cord-018089-m94q75xn	269	16	in	in	IN
cord-018089-m94q75xn	269	17	the	the	DT
cord-018089-m94q75xn	269	18	Netherlands	Netherlands	NNP
cord-018089-m94q75xn	269	19	Avian	Avian	NNP
cord-018089-m94q75xn	269	20	influenza	influenza	NN
cord-018089-m94q75xn	269	21	A	a	DT
cord-018089-m94q75xn	269	22	virus	virus	NN
cord-018089-m94q75xn	269	23	(	(	-LRB-
cord-018089-m94q75xn	269	24	H7N7	H7N7	NNP
cord-018089-m94q75xn	269	25	)	)	-RRB-
cord-018089-m94q75xn	269	26	associated	associate	VBN
cord-018089-m94q75xn	269	27	with	with	IN
cord-018089-m94q75xn	269	28	human	human	JJ
cord-018089-m94q75xn	269	29	conjunctivitis	conjunctivitis	NN
cord-018089-m94q75xn	269	30	and	and	CC
cord-018089-m94q75xn	269	31	a	a	DT
cord-018089-m94q75xn	269	32	fatal	fatal	JJ
cord-018089-m94q75xn	269	33	case	case	NN
cord-018089-m94q75xn	269	34	of	of	IN
cord-018089-m94q75xn	269	35	acute	acute	JJ
cord-018089-m94q75xn	269	36	respiratory	respiratory	JJ
cord-018089-m94q75xn	269	37	distress	distress	NN
cord-018089-m94q75xn	269	38	syndrome	syndrome	NN
cord-018089-m94q75xn	270	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	270	2	A	a	DT
cord-018089-m94q75xn	270	3	H5N1	H5N1	NNP
cord-018089-m94q75xn	270	4	replication	replication	NN
cord-018089-m94q75xn	270	5	sites	site	NNS
cord-018089-m94q75xn	270	6	in	in	IN
cord-018089-m94q75xn	270	7	humans	human	NNS
cord-018089-m94q75xn	270	8	Tropism	tropism	NN
cord-018089-m94q75xn	270	9	of	of	IN
cord-018089-m94q75xn	270	10	avian	avian	JJ
cord-018089-m94q75xn	270	11	influenza	influenza	NN
cord-018089-m94q75xn	270	12	A	a	NN
cord-018089-m94q75xn	270	13	(	(	-LRB-
cord-018089-m94q75xn	270	14	H5N1	H5N1	NNP
cord-018089-m94q75xn	270	15	)	)	-RRB-
cord-018089-m94q75xn	270	16	in	in	IN
cord-018089-m94q75xn	270	17	the	the	DT
cord-018089-m94q75xn	270	18	upper	upper	JJ
cord-018089-m94q75xn	270	19	and	and	CC
cord-018089-m94q75xn	270	20	lower	low	JJR
cord-018089-m94q75xn	270	21	respiratory	respiratory	JJ
cord-018089-m94q75xn	270	22	tract	tract	NN
cord-018089-m94q75xn	270	23	Haemagglutinin	Haemagglutinin	NNP
cord-018089-m94q75xn	270	24	mutations	mutation	NNS
cord-018089-m94q75xn	270	25	responsible	responsible	JJ
cord-018089-m94q75xn	270	26	for	for	IN
cord-018089-m94q75xn	270	27	the	the	DT
cord-018089-m94q75xn	270	28	binding	binding	NN
cord-018089-m94q75xn	270	29	of	of	IN
cord-018089-m94q75xn	270	30	H5N1	H5N1	NNP
cord-018089-m94q75xn	270	31	influenza	influenza	NN
cord-018089-m94q75xn	270	32	A	a	DT
cord-018089-m94q75xn	270	33	viruses	virus	NNS
cord-018089-m94q75xn	270	34	to	to	IN
cord-018089-m94q75xn	270	35	human	human	JJ
cord-018089-m94q75xn	270	36	-	-	HYPH
cord-018089-m94q75xn	270	37	type	type	NN
cord-018089-m94q75xn	270	38	receptors	receptor	NNS
cord-018089-m94q75xn	270	39	Differences	difference	NNS
cord-018089-m94q75xn	270	40	between	between	IN
cord-018089-m94q75xn	270	41	influenza	influenza	NN
cord-018089-m94q75xn	270	42	virus	virus	NN
cord-018089-m94q75xn	270	43	receptors	receptor	NNS
cord-018089-m94q75xn	270	44	on	on	IN
cord-018089-m94q75xn	270	45	target	target	NN
cord-018089-m94q75xn	270	46	cells	cell	NNS
cord-018089-m94q75xn	270	47	of	of	IN
cord-018089-m94q75xn	270	48	duck	duck	NN
cord-018089-m94q75xn	270	49	and	and	CC
cord-018089-m94q75xn	270	50	chicken	chicken	NN
cord-018089-m94q75xn	270	51	and	and	CC
cord-018089-m94q75xn	270	52	receptor	receptor	NN
cord-018089-m94q75xn	270	53	specificity	specificity	NN
cord-018089-m94q75xn	270	54	of	of	IN
cord-018089-m94q75xn	270	55	the	the	DT
cord-018089-m94q75xn	270	56	1997	1997	CD
cord-018089-m94q75xn	270	57	H5N1	H5N1	NNP
cord-018089-m94q75xn	270	58	chicken	chicken	NN
cord-018089-m94q75xn	270	59	and	and	CC
cord-018089-m94q75xn	270	60	human	human	JJ
cord-018089-m94q75xn	270	61	influenza	influenza	NN
cord-018089-m94q75xn	270	62	viruses	virus	NNS
cord-018089-m94q75xn	270	63	from	from	IN
cord-018089-m94q75xn	270	64	Hong	Hong	NNP
cord-018089-m94q75xn	270	65	Kong	Kong	NNP
cord-018089-m94q75xn	270	66	Quail	Quail	NNP
cord-018089-m94q75xn	270	67	carry	carry	VBP
cord-018089-m94q75xn	270	68	sialic	sialic	JJ
cord-018089-m94q75xn	270	69	acid	acid	NN
cord-018089-m94q75xn	270	70	receptors	receptor	NNS
cord-018089-m94q75xn	270	71	compatible	compatible	JJ
cord-018089-m94q75xn	270	72	with	with	IN
cord-018089-m94q75xn	270	73	binding	binding	NN
cord-018089-m94q75xn	270	74	of	of	IN
cord-018089-m94q75xn	270	75	avian	avian	JJ
cord-018089-m94q75xn	270	76	and	and	CC
cord-018089-m94q75xn	270	77	human	human	JJ
cord-018089-m94q75xn	270	78	influenza	influenza	NN
cord-018089-m94q75xn	270	79	viruses	viruse	VBZ
cord-018089-m94q75xn	270	80	Evidence	evidence	NN
cord-018089-m94q75xn	270	81	for	for	IN
cord-018089-m94q75xn	270	82	interspecies	interspecie	NNS
cord-018089-m94q75xn	270	83	transmission	transmission	NN
cord-018089-m94q75xn	270	84	and	and	CC
cord-018089-m94q75xn	270	85	reassortment	reassortment	NN
cord-018089-m94q75xn	270	86	of	of	IN
cord-018089-m94q75xn	270	87	influenza	influenza	NN
cord-018089-m94q75xn	270	88	A	a	DT
cord-018089-m94q75xn	270	89	viruses	virus	NNS
cord-018089-m94q75xn	270	90	in	in	IN
cord-018089-m94q75xn	270	91	pigs	pig	NNS
cord-018089-m94q75xn	270	92	in	in	IN
cord-018089-m94q75xn	270	93	southern	southern	JJ
cord-018089-m94q75xn	270	94	China	China	NNP
cord-018089-m94q75xn	270	95	Genetic	genetic	JJ
cord-018089-m94q75xn	270	96	reassortment	reassortment	NN
cord-018089-m94q75xn	270	97	between	between	IN
cord-018089-m94q75xn	271	1	avian	avian	JJ
cord-018089-m94q75xn	271	2	and	and	CC
cord-018089-m94q75xn	271	3	human	human	JJ
cord-018089-m94q75xn	271	4	influenza	influenza	NN
cord-018089-m94q75xn	271	5	A	a	DT
cord-018089-m94q75xn	271	6	viruses	virus	NNS
cord-018089-m94q75xn	271	7	in	in	IN
cord-018089-m94q75xn	271	8	Italian	italian	JJ
cord-018089-m94q75xn	271	9	pigs	pig	NNS
cord-018089-m94q75xn	272	1	Does	do	VBZ
cord-018089-m94q75xn	272	2	this	this	DT
cord-018089-m94q75xn	272	3	patient	patient	NN
cord-018089-m94q75xn	272	4	have	have	VB
cord-018089-m94q75xn	272	5	influenza	influenza	NN
cord-018089-m94q75xn	272	6	Influenza	Influenza	NNP
cord-018089-m94q75xn	272	7	-	-	HYPH
cord-018089-m94q75xn	272	8	associated	associate	VBN
cord-018089-m94q75xn	272	9	deaths	death	NNS
cord-018089-m94q75xn	272	10	among	among	IN
cord-018089-m94q75xn	272	11	children	child	NNS
cord-018089-m94q75xn	272	12	in	in	IN
cord-018089-m94q75xn	272	13	the	the	DT
cord-018089-m94q75xn	272	14	United	United	NNP
cord-018089-m94q75xn	272	15	States	States	NNP
cord-018089-m94q75xn	272	16	Influenza	Influenza	NNP
cord-018089-m94q75xn	272	17	A	a	DT
cord-018089-m94q75xn	272	18	virus	virus	NN
cord-018089-m94q75xn	272	19	infection	infection	NN
cord-018089-m94q75xn	272	20	complicated	complicate	VBN
cord-018089-m94q75xn	272	21	by	by	IN
cord-018089-m94q75xn	272	22	fatal	fatal	JJ
cord-018089-m94q75xn	272	23	myocarditis	myocarditis	NN
cord-018089-m94q75xn	272	24	Influenza	Influenza	NNP
cord-018089-m94q75xn	272	25	vaccination	vaccination	NN
cord-018089-m94q75xn	272	26	as	as	IN
cord-018089-m94q75xn	272	27	secondary	secondary	JJ
cord-018089-m94q75xn	272	28	prevention	prevention	NN
cord-018089-m94q75xn	272	29	for	for	IN
cord-018089-m94q75xn	272	30	cardiovascular	cardiovascular	JJ
cord-018089-m94q75xn	272	31	disease	disease	NN
cord-018089-m94q75xn	272	32	:	:	:
cord-018089-m94q75xn	272	33	a	a	DT
cord-018089-m94q75xn	272	34	science	science	NN
cord-018089-m94q75xn	272	35	advisory	advisory	NN
cord-018089-m94q75xn	272	36	from	from	IN
cord-018089-m94q75xn	272	37	the	the	DT
cord-018089-m94q75xn	272	38	American	American	NNP
cord-018089-m94q75xn	272	39	Heart	Heart	NNP
cord-018089-m94q75xn	272	40	Association	Association	NNP
cord-018089-m94q75xn	272	41	/	/	SYM
cord-018089-m94q75xn	272	42	American	American	NNP
cord-018089-m94q75xn	272	43	College	College	NNP
cord-018089-m94q75xn	272	44	of	of	IN
cord-018089-m94q75xn	272	45	Cardiology	Cardiology	NNP
cord-018089-m94q75xn	272	46	Histopathologic	Histopathologic	NNP
cord-018089-m94q75xn	272	47	and	and	CC
cord-018089-m94q75xn	272	48	immunohistochemical	immunohistochemical	JJ
cord-018089-m94q75xn	272	49	features	feature	NNS
cord-018089-m94q75xn	272	50	of	of	IN
cord-018089-m94q75xn	272	51	fatal	fatal	JJ
cord-018089-m94q75xn	272	52	influenza	influenza	NN
cord-018089-m94q75xn	272	53	virus	virus	NN
cord-018089-m94q75xn	272	54	infection	infection	NN
cord-018089-m94q75xn	272	55	in	in	IN
cord-018089-m94q75xn	272	56	children	child	NNS
cord-018089-m94q75xn	272	57	during	during	IN
cord-018089-m94q75xn	272	58	the	the	DT
cord-018089-m94q75xn	272	59	2003	2003	CD
cord-018089-m94q75xn	272	60	-	-	SYM
cord-018089-m94q75xn	272	61	2004	2004	CD
cord-018089-m94q75xn	272	62	season	season	NN
cord-018089-m94q75xn	272	63	Outbreak	outbreak	NN
cord-018089-m94q75xn	272	64	of	of	IN
cord-018089-m94q75xn	272	65	avian	avian	JJ
cord-018089-m94q75xn	272	66	influenza	influenza	NN
cord-018089-m94q75xn	272	67	A(H5N1	A(H5N1	NNP
cord-018089-m94q75xn	272	68	)	)	-RRB-
cord-018089-m94q75xn	272	69	virus	virus	NN
cord-018089-m94q75xn	272	70	infection	infection	NN
cord-018089-m94q75xn	272	71	in	in	IN
cord-018089-m94q75xn	272	72	Hong	Hong	NNP
cord-018089-m94q75xn	272	73	Kong	Kong	NNP
cord-018089-m94q75xn	272	74	in	in	IN
cord-018089-m94q75xn	272	75	1997	1997	CD
cord-018089-m94q75xn	273	1	Avian	avian	JJ
cord-018089-m94q75xn	273	2	influenza	influenza	NN
cord-018089-m94q75xn	273	3	A	a	NN
cord-018089-m94q75xn	273	4	(	(	-LRB-
cord-018089-m94q75xn	273	5	H5N1	H5N1	NNP
cord-018089-m94q75xn	273	6	)	)	-RRB-
cord-018089-m94q75xn	273	7	infection	infection	NN
cord-018089-m94q75xn	273	8	in	in	IN
cord-018089-m94q75xn	273	9	humans	human	NNS
cord-018089-m94q75xn	273	10	Human	human	JJ
cord-018089-m94q75xn	273	11	disease	disease	NN
cord-018089-m94q75xn	273	12	from	from	IN
cord-018089-m94q75xn	273	13	influenza	influenza	NN
cord-018089-m94q75xn	273	14	A	A	NNP
cord-018089-m94q75xn	273	15	(	(	-LRB-
cord-018089-m94q75xn	273	16	H5N1	H5N1	NNP
cord-018089-m94q75xn	273	17	)	)	-RRB-
cord-018089-m94q75xn	273	18	Predominant	predominant	JJ
cord-018089-m94q75xn	273	19	role	role	NN
cord-018089-m94q75xn	273	20	of	of	IN
cord-018089-m94q75xn	273	21	bacterial	bacterial	JJ
cord-018089-m94q75xn	273	22	pneumonia	pneumonia	NN
cord-018089-m94q75xn	273	23	as	as	IN
cord-018089-m94q75xn	273	24	a	a	DT
cord-018089-m94q75xn	273	25	cause	cause	NN
cord-018089-m94q75xn	273	26	of	of	IN
cord-018089-m94q75xn	273	27	death	death	NN
cord-018089-m94q75xn	273	28	in	in	IN
cord-018089-m94q75xn	273	29	pandemic	pandemic	NN
cord-018089-m94q75xn	273	30	influenza	influenza	NN
cord-018089-m94q75xn	273	31	:	:	:
cord-018089-m94q75xn	273	32	implications	implication	NNS
cord-018089-m94q75xn	273	33	for	for	IN
cord-018089-m94q75xn	273	34	pandemic	pandemic	NN
cord-018089-m94q75xn	273	35	influenza	influenza	NN
cord-018089-m94q75xn	273	36	preparedness	preparedness	NN
cord-018089-m94q75xn	273	37	Influenza	Influenza	NNP
cord-018089-m94q75xn	273	38	-	-	HYPH
cord-018089-m94q75xn	273	39	associated	associate	VBN
cord-018089-m94q75xn	273	40	pediatric	pediatric	JJ
cord-018089-m94q75xn	273	41	mortality	mortality	NN
cord-018089-m94q75xn	273	42	in	in	IN
cord-018089-m94q75xn	273	43	the	the	DT
cord-018089-m94q75xn	273	44	United	United	NNP
cord-018089-m94q75xn	273	45	States	States	NNP
cord-018089-m94q75xn	273	46	:	:	:
cord-018089-m94q75xn	273	47	increase	increase	NN
cord-018089-m94q75xn	273	48	of	of	IN
cord-018089-m94q75xn	273	49	Staphylococcus	Staphylococcus	NNP
cord-018089-m94q75xn	273	50	aureus	aureus	NN
cord-018089-m94q75xn	273	51	coinfection	coinfection	VBD
cord-018089-m94q75xn	273	52	Infection	infection	NN
cord-018089-m94q75xn	273	53	with	with	IN
cord-018089-m94q75xn	273	54	community	community	NN
cord-018089-m94q75xn	273	55	-	-	HYPH
cord-018089-m94q75xn	273	56	onset	onset	NN
cord-018089-m94q75xn	273	57	Staphylococcus	Staphylococcus	NNP
cord-018089-m94q75xn	273	58	aureus	aureus	NN
cord-018089-m94q75xn	273	59	and	and	CC
cord-018089-m94q75xn	273	60	influenza	influenza	NN
cord-018089-m94q75xn	273	61	virus	virus	NN
cord-018089-m94q75xn	273	62	in	in	IN
cord-018089-m94q75xn	273	63	hospitalized	hospitalize	VBN
cord-018089-m94q75xn	273	64	children	child	NNS
cord-018089-m94q75xn	273	65	Surveillance	surveillance	NN
cord-018089-m94q75xn	273	66	for	for	IN
cord-018089-m94q75xn	273	67	pediatric	pediatric	JJ
cord-018089-m94q75xn	273	68	deaths	death	NNS
cord-018089-m94q75xn	273	69	associated	associate	VBN
cord-018089-m94q75xn	273	70	with	with	IN
cord-018089-m94q75xn	273	71	2009	2009	CD
cord-018089-m94q75xn	273	72	pandemic	pandemic	NN
cord-018089-m94q75xn	273	73	influenza	influenza	NN
cord-018089-m94q75xn	273	74	A	A	NNP
cord-018089-m94q75xn	273	75	(	(	-LRB-
cord-018089-m94q75xn	273	76	H1N1	H1N1	NNP
cord-018089-m94q75xn	273	77	)	)	-RRB-
cord-018089-m94q75xn	273	78	virus	virus	NN
cord-018089-m94q75xn	273	79	infection	infection	NN
cord-018089-m94q75xn	273	80	-United	-unite	VBD
cord-018089-m94q75xn	273	81	States	States	NNP
cord-018089-m94q75xn	273	82	H1N1	H1N1	NNP
cord-018089-m94q75xn	273	83	2009	2009	CD
cord-018089-m94q75xn	273	84	influenza	influenza	NN
cord-018089-m94q75xn	273	85	virus	virus	NN
cord-018089-m94q75xn	273	86	infection	infection	NN
cord-018089-m94q75xn	273	87	during	during	IN
cord-018089-m94q75xn	273	88	pregnancy	pregnancy	NN
cord-018089-m94q75xn	273	89	in	in	IN
cord-018089-m94q75xn	273	90	the	the	DT
cord-018089-m94q75xn	273	91	USA	USA	NNP
cord-018089-m94q75xn	273	92	Reducing	reduce	VBG
cord-018089-m94q75xn	273	93	the	the	DT
cord-018089-m94q75xn	273	94	risk	risk	NN
cord-018089-m94q75xn	273	95	of	of	IN
cord-018089-m94q75xn	273	96	pandemic	pandemic	NN
cord-018089-m94q75xn	273	97	influenza	influenza	NN
cord-018089-m94q75xn	273	98	in	in	IN
cord-018089-m94q75xn	273	99	Aboriginal	aboriginal	JJ
cord-018089-m94q75xn	273	100	communities	community	NNS
cord-018089-m94q75xn	273	101	Pandemic	Pandemic	NNP
cord-018089-m94q75xn	273	102	influenza	influenza	NN
cord-018089-m94q75xn	273	103	A(H1N1)v	a(h1n1)v	NN
cord-018089-m94q75xn	273	104	in	in	IN
cord-018089-m94q75xn	273	105	New	New	NNP
cord-018089-m94q75xn	273	106	Zealand	Zealand	NNP
cord-018089-m94q75xn	273	107	:	:	:
cord-018089-m94q75xn	273	108	the	the	DT
cord-018089-m94q75xn	273	109	experience	experience	NN
cord-018089-m94q75xn	273	110	from	from	IN
cord-018089-m94q75xn	273	111	The	the	DT
cord-018089-m94q75xn	273	112	comparative	comparative	JJ
cord-018089-m94q75xn	273	113	pathology	pathology	NN
cord-018089-m94q75xn	273	114	of	of	IN
cord-018089-m94q75xn	273	115	severe	severe	JJ
cord-018089-m94q75xn	273	116	acute	acute	JJ
cord-018089-m94q75xn	273	117	respiratory	respiratory	JJ
cord-018089-m94q75xn	273	118	syndrome	syndrome	NN
cord-018089-m94q75xn	273	119	and	and	CC
cord-018089-m94q75xn	274	1	avian	avian	JJ
cord-018089-m94q75xn	274	2	influenza	influenza	NN
cord-018089-m94q75xn	274	3	A	a	DT
cord-018089-m94q75xn	274	4	subtype	subtype	NN
cord-018089-m94q75xn	275	1	H5N1	H5N1	NNP
cord-018089-m94q75xn	275	2	-a	-a	NNP
cord-018089-m94q75xn	275	3	review	review	NNP
cord-018089-m94q75xn	275	4	Pathology	Pathology	NNP
cord-018089-m94q75xn	275	5	of	of	IN
cord-018089-m94q75xn	275	6	fatal	fatal	JJ
cord-018089-m94q75xn	275	7	human	human	JJ
cord-018089-m94q75xn	275	8	infection	infection	NN
cord-018089-m94q75xn	275	9	associated	associate	VBN
cord-018089-m94q75xn	275	10	with	with	IN
cord-018089-m94q75xn	275	11	avian	avian	JJ
cord-018089-m94q75xn	275	12	influenza	influenza	NN
cord-018089-m94q75xn	275	13	A	a	DT
cord-018089-m94q75xn	275	14	H5N1	H5N1	NNP
cord-018089-m94q75xn	275	15	virus	virus	NN
cord-018089-m94q75xn	275	16	Proinflammatory	Proinflammatory	NNP
cord-018089-m94q75xn	275	17	cytokine	cytokine	NN
cord-018089-m94q75xn	275	18	responses	response	NNS
cord-018089-m94q75xn	275	19	induced	induce	VBN
cord-018089-m94q75xn	275	20	by	by	IN
cord-018089-m94q75xn	275	21	influenza	influenza	NN
cord-018089-m94q75xn	275	22	A	a	NN
cord-018089-m94q75xn	275	23	(	(	-LRB-
cord-018089-m94q75xn	275	24	H5N1	H5N1	NNP
cord-018089-m94q75xn	275	25	)	)	-RRB-
cord-018089-m94q75xn	275	26	viruses	virus	NNS
cord-018089-m94q75xn	275	27	in	in	IN
cord-018089-m94q75xn	275	28	primary	primary	JJ
cord-018089-m94q75xn	275	29	human	human	JJ
cord-018089-m94q75xn	275	30	alveolar	alveolar	NN
cord-018089-m94q75xn	275	31	and	and	CC
cord-018089-m94q75xn	275	32	bronchial	bronchial	JJ
cord-018089-m94q75xn	275	33	epithelial	epithelial	JJ
cord-018089-m94q75xn	275	34	cells	cell	NNS
cord-018089-m94q75xn	276	1	Detrimental	detrimental	JJ
cord-018089-m94q75xn	276	2	contribution	contribution	NN
cord-018089-m94q75xn	276	3	of	of	IN
cord-018089-m94q75xn	276	4	the	the	DT
cord-018089-m94q75xn	276	5	Toll	Toll	NNP
cord-018089-m94q75xn	276	6	-	-	HYPH
cord-018089-m94q75xn	276	7	like	like	JJ
cord-018089-m94q75xn	276	8	receptor	receptor	NN
cord-018089-m94q75xn	276	9	(	(	-LRB-
cord-018089-m94q75xn	276	10	TLR)3	tlr)3	XX
cord-018089-m94q75xn	276	11	to	to	TO
cord-018089-m94q75xn	276	12	influenza	influenza	VB
cord-018089-m94q75xn	276	13	A	a	DT
cord-018089-m94q75xn	276	14	virus	virus	NN
cord-018089-m94q75xn	276	15	-	-	HYPH
cord-018089-m94q75xn	276	16	induced	induce	VBN
cord-018089-m94q75xn	276	17	acute	acute	JJ
cord-018089-m94q75xn	276	18	pneumonia	pneumonia	NN
cord-018089-m94q75xn	276	19	Type	type	NN
cord-018089-m94q75xn	276	20	I	-PRON-	PRP
cord-018089-m94q75xn	276	21	IFNs	ifns	VBP
cord-018089-m94q75xn	276	22	mediate	mediate	VB
cord-018089-m94q75xn	276	23	development	development	NN
cord-018089-m94q75xn	276	24	of	of	IN
cord-018089-m94q75xn	276	25	postinfluenza	postinfluenza	NNP
cord-018089-m94q75xn	276	26	bacterial	bacterial	JJ
cord-018089-m94q75xn	276	27	pneumonia	pneumonia	NN
cord-018089-m94q75xn	276	28	in	in	IN
cord-018089-m94q75xn	276	29	mice	mouse	NNS
cord-018089-m94q75xn	276	30	IL-10	IL-10	NNP
cord-018089-m94q75xn	276	31	is	be	VBZ
cord-018089-m94q75xn	276	32	an	an	DT
cord-018089-m94q75xn	276	33	important	important	JJ
cord-018089-m94q75xn	276	34	mediator	mediator	NN
cord-018089-m94q75xn	276	35	of	of	IN
cord-018089-m94q75xn	276	36	the	the	DT
cord-018089-m94q75xn	276	37	enhanced	enhanced	JJ
cord-018089-m94q75xn	276	38	susceptibility	susceptibility	NN
cord-018089-m94q75xn	276	39	to	to	IN
cord-018089-m94q75xn	276	40	pneumococcal	pneumococcal	JJ
cord-018089-m94q75xn	276	41	pneumonia	pneumonia	NN
cord-018089-m94q75xn	276	42	after	after	IN
cord-018089-m94q75xn	276	43	influenza	influenza	NN
cord-018089-m94q75xn	276	44	infection	infection	NN
cord-018089-m94q75xn	276	45	Inhibition	inhibition	NN
cord-018089-m94q75xn	276	46	of	of	IN
cord-018089-m94q75xn	276	47	pulmonary	pulmonary	JJ
cord-018089-m94q75xn	276	48	antibacterial	antibacterial	JJ
cord-018089-m94q75xn	276	49	defense	defense	NN
cord-018089-m94q75xn	276	50	by	by	IN
cord-018089-m94q75xn	276	51	interferongamma	interferongamma	NNP
cord-018089-m94q75xn	276	52	during	during	IN
cord-018089-m94q75xn	276	53	recovery	recovery	NN
cord-018089-m94q75xn	276	54	from	from	IN
cord-018089-m94q75xn	276	55	influenza	influenza	NN
cord-018089-m94q75xn	276	56	infection	infection	NN
cord-018089-m94q75xn	276	57	Expression	expression	NN
cord-018089-m94q75xn	276	58	of	of	IN
cord-018089-m94q75xn	276	59	the	the	DT
cord-018089-m94q75xn	276	60	1918	1918	CD
cord-018089-m94q75xn	276	61	influenza	influenza	NN
cord-018089-m94q75xn	276	62	A	a	DT
cord-018089-m94q75xn	276	63	virus	virus	NN
cord-018089-m94q75xn	276	64	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	276	65	enhances	enhance	VBZ
cord-018089-m94q75xn	276	66	the	the	DT
cord-018089-m94q75xn	276	67	pathogenesis	pathogenesis	NN
cord-018089-m94q75xn	276	68	of	of	IN
cord-018089-m94q75xn	277	1	viral	viral	JJ
cord-018089-m94q75xn	277	2	and	and	CC
cord-018089-m94q75xn	277	3	secondary	secondary	JJ
cord-018089-m94q75xn	277	4	bacterial	bacterial	JJ
cord-018089-m94q75xn	277	5	pneumonia	pneumonia	NN
cord-018089-m94q75xn	277	6	Influenza	Influenza	NNP
cord-018089-m94q75xn	277	7	virus	virus	NN
cord-018089-m94q75xn	277	8	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	277	9	contributes	contribute	VBZ
cord-018089-m94q75xn	277	10	to	to	IN
cord-018089-m94q75xn	277	11	secondary	secondary	JJ
cord-018089-m94q75xn	277	12	bacterial	bacterial	JJ
cord-018089-m94q75xn	277	13	pneumonia	pneumonia	NN
cord-018089-m94q75xn	277	14	Molecular	molecular	JJ
cord-018089-m94q75xn	277	15	basis	basis	NN
cord-018089-m94q75xn	277	16	for	for	IN
cord-018089-m94q75xn	277	17	high	high	JJ
cord-018089-m94q75xn	277	18	virulence	virulence	NN
cord-018089-m94q75xn	277	19	of	of	IN
cord-018089-m94q75xn	277	20	Hong	Hong	NNP
cord-018089-m94q75xn	277	21	Kong	Kong	NNP
cord-018089-m94q75xn	277	22	H5N1	H5N1	NNP
cord-018089-m94q75xn	278	1	influenza	influenza	NN
cord-018089-m94q75xn	278	2	A	a	DT
cord-018089-m94q75xn	278	3	viruses	virus	NNS
cord-018089-m94q75xn	279	1	The	the	DT
cord-018089-m94q75xn	279	2	polymerase	polymerase	NN
cord-018089-m94q75xn	279	3	complex	complex	JJ
cord-018089-m94q75xn	279	4	genes	gene	NNS
cord-018089-m94q75xn	279	5	contribute	contribute	VBP
cord-018089-m94q75xn	279	6	to	to	IN
cord-018089-m94q75xn	279	7	the	the	DT
cord-018089-m94q75xn	279	8	high	high	JJ
cord-018089-m94q75xn	279	9	virulence	virulence	NN
cord-018089-m94q75xn	279	10	of	of	IN
cord-018089-m94q75xn	279	11	the	the	DT
cord-018089-m94q75xn	279	12	human	human	JJ
cord-018089-m94q75xn	279	13	H5N1	H5N1	NNP
cord-018089-m94q75xn	279	14	influenza	influenza	NN
cord-018089-m94q75xn	279	15	virus	virus	NN
cord-018089-m94q75xn	280	1	isolate	isolate	VB
cord-018089-m94q75xn	280	2	A	a	DT
cord-018089-m94q75xn	280	3	/	/	SYM
cord-018089-m94q75xn	280	4	Vietnam/1203/04	vietnam/1203/04	JJ
cord-018089-m94q75xn	280	5	Avian	avian	JJ
cord-018089-m94q75xn	280	6	influenza	influenza	NN
cord-018089-m94q75xn	280	7	(	(	-LRB-
cord-018089-m94q75xn	280	8	H5N1	H5N1	NNP
cord-018089-m94q75xn	280	9	)	)	-RRB-
cord-018089-m94q75xn	280	10	viruses	virus	NNS
cord-018089-m94q75xn	280	11	isolated	isolate	VBN
cord-018089-m94q75xn	280	12	from	from	IN
cord-018089-m94q75xn	280	13	humans	human	NNS
cord-018089-m94q75xn	280	14	in	in	IN
cord-018089-m94q75xn	280	15	Asia	Asia	NNP
cord-018089-m94q75xn	280	16	in	in	IN
cord-018089-m94q75xn	280	17	2004	2004	CD
cord-018089-m94q75xn	281	1	exhibit	exhibit	NN
cord-018089-m94q75xn	281	2	increased	increase	VBN
cord-018089-m94q75xn	281	3	virulence	virulence	NN
cord-018089-m94q75xn	281	4	in	in	IN
cord-018089-m94q75xn	281	5	mammals	mammal	NNS
cord-018089-m94q75xn	282	1	Residue	Residue	NNP
cord-018089-m94q75xn	282	2	627	627	CD
cord-018089-m94q75xn	282	3	of	of	IN
cord-018089-m94q75xn	282	4	PB2	PB2	NNP
cord-018089-m94q75xn	282	5	is	be	VBZ
cord-018089-m94q75xn	282	6	a	a	DT
cord-018089-m94q75xn	282	7	determinant	determinant	NN
cord-018089-m94q75xn	282	8	of	of	IN
cord-018089-m94q75xn	282	9	cold	cold	JJ
cord-018089-m94q75xn	282	10	sensitivity	sensitivity	NN
cord-018089-m94q75xn	282	11	in	in	IN
cord-018089-m94q75xn	282	12	RNA	RNA	NNP
cord-018089-m94q75xn	282	13	replication	replication	NN
cord-018089-m94q75xn	282	14	of	of	IN
cord-018089-m94q75xn	282	15	avian	avian	JJ
cord-018089-m94q75xn	282	16	influenza	influenza	NN
cord-018089-m94q75xn	282	17	viruses	viruse	VBZ
cord-018089-m94q75xn	282	18	Transmission	Transmission	NNP
cord-018089-m94q75xn	282	19	of	of	IN
cord-018089-m94q75xn	282	20	influenza	influenza	NN
cord-018089-m94q75xn	282	21	virus	virus	NN
cord-018089-m94q75xn	282	22	in	in	IN
cord-018089-m94q75xn	282	23	a	a	DT
cord-018089-m94q75xn	282	24	mammalian	mammalian	JJ
cord-018089-m94q75xn	282	25	host	host	NN
cord-018089-m94q75xn	282	26	is	be	VBZ
cord-018089-m94q75xn	282	27	increased	increase	VBN
cord-018089-m94q75xn	282	28	by	by	IN
cord-018089-m94q75xn	282	29	PB2	PB2	NNP
cord-018089-m94q75xn	282	30	amino	amino	JJ
cord-018089-m94q75xn	282	31	acids	acid	NNS
cord-018089-m94q75xn	282	32	627	627	CD
cord-018089-m94q75xn	282	33	K	K	NNP
cord-018089-m94q75xn	282	34	or	or	CC
cord-018089-m94q75xn	282	35	627E/701N	627e/701n	CD
cord-018089-m94q75xn	283	1	Influenza	influenza	NN
cord-018089-m94q75xn	283	2	virus	virus	NN
cord-018089-m94q75xn	283	3	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	283	4	protein	protein	NN
cord-018089-m94q75xn	283	5	induces	induce	VBZ
cord-018089-m94q75xn	283	6	cell	cell	NN
cord-018089-m94q75xn	283	7	death	death	NN
cord-018089-m94q75xn	283	8	through	through	IN
cord-018089-m94q75xn	283	9	mitochondrial	mitochondrial	JJ
cord-018089-m94q75xn	283	10	ANT3	ANT3	NNP
cord-018089-m94q75xn	283	11	and	and	CC
cord-018089-m94q75xn	283	12	VDAC1	vdac1	NN
cord-018089-m94q75xn	284	1	Influenza	Influenza	NNP
cord-018089-m94q75xn	284	2	A	a	DT
cord-018089-m94q75xn	284	3	virus	virus	NN
cord-018089-m94q75xn	284	4	PB1-F2	PB1-F2	NNP
cord-018089-m94q75xn	284	5	protein	protein	NN
cord-018089-m94q75xn	284	6	contributes	contribute	VBZ
cord-018089-m94q75xn	284	7	to	to	IN
cord-018089-m94q75xn	284	8	viral	viral	JJ
cord-018089-m94q75xn	284	9	pathogenesis	pathogenesis	NN
cord-018089-m94q75xn	284	10	in	in	IN
cord-018089-m94q75xn	284	11	mice	mice	NN
cord-018089-m94q75xn	284	12	Type	type	NN
cord-018089-m94q75xn	284	13	1	1	CD
cord-018089-m94q75xn	284	14	interferons	interferon	NNS
cord-018089-m94q75xn	284	15	and	and	CC
cord-018089-m94q75xn	284	16	the	the	DT
cord-018089-m94q75xn	284	17	virus	virus	NN
cord-018089-m94q75xn	284	18	-	-	HYPH
cord-018089-m94q75xn	284	19	host	host	NN
cord-018089-m94q75xn	284	20	relationship	relationship	NN
cord-018089-m94q75xn	284	21	:	:	:
cord-018089-m94q75xn	284	22	a	a	DT
cord-018089-m94q75xn	284	23	lesson	lesson	NN
cord-018089-m94q75xn	284	24	in	in	IN
cord-018089-m94q75xn	284	25	detente	detente	NN
cord-018089-m94q75xn	285	1	The	the	DT
cord-018089-m94q75xn	285	2	multifunctional	multifunctional	JJ
cord-018089-m94q75xn	285	3	NS1	ns1	NN
cord-018089-m94q75xn	285	4	protein	protein	NN
cord-018089-m94q75xn	285	5	of	of	IN
cord-018089-m94q75xn	285	6	influenza	influenza	NN
cord-018089-m94q75xn	285	7	A	a	DT
cord-018089-m94q75xn	285	8	viruses	virus	NNS
cord-018089-m94q75xn	285	9	The	the	DT
cord-018089-m94q75xn	285	10	NS1	ns1	NN
cord-018089-m94q75xn	285	11	gene	gene	NN
cord-018089-m94q75xn	285	12	contributes	contribute	VBZ
cord-018089-m94q75xn	285	13	to	to	IN
cord-018089-m94q75xn	285	14	the	the	DT
cord-018089-m94q75xn	285	15	virulence	virulence	NN
cord-018089-m94q75xn	285	16	of	of	IN
cord-018089-m94q75xn	285	17	H5N1	H5N1	NNP
cord-018089-m94q75xn	285	18	avian	avian	JJ
cord-018089-m94q75xn	285	19	influenza	influenza	NN
cord-018089-m94q75xn	285	20	viruses	viruse	VBZ
cord-018089-m94q75xn	285	21	Large	large	JJ
cord-018089-m94q75xn	285	22	-	-	HYPH
cord-018089-m94q75xn	285	23	scale	scale	NN
cord-018089-m94q75xn	285	24	sequence	sequence	NN
cord-018089-m94q75xn	285	25	analysis	analysis	NN
cord-018089-m94q75xn	285	26	of	of	IN
cord-018089-m94q75xn	285	27	avian	avian	JJ
cord-018089-m94q75xn	285	28	influenza	influenza	NN
cord-018089-m94q75xn	286	1	isolates	isolate	NNS
cord-018089-m94q75xn	287	1	Glycosylation	glycosylation	NN
cord-018089-m94q75xn	287	2	of	of	IN
cord-018089-m94q75xn	287	3	neuraminidase	neuraminidase	NN
cord-018089-m94q75xn	287	4	determines	determine	VBZ
cord-018089-m94q75xn	287	5	the	the	DT
cord-018089-m94q75xn	287	6	neurovirulence	neurovirulence	NN
cord-018089-m94q75xn	287	7	of	of	IN
cord-018089-m94q75xn	287	8	influenza	influenza	NN
cord-018089-m94q75xn	287	9	A	A	NNP
cord-018089-m94q75xn	287	10	/	/	SYM
cord-018089-m94q75xn	287	11	WSN/33	wsn/33	JJ
cord-018089-m94q75xn	287	12	virus	virus	NN
cord-018089-m94q75xn	287	13	Sequence	sequence	NN
cord-018089-m94q75xn	287	14	requirements	requirement	NNS
cord-018089-m94q75xn	287	15	for	for	IN
cord-018089-m94q75xn	287	16	cleavage	cleavage	NN
cord-018089-m94q75xn	287	17	activation	activation	NN
cord-018089-m94q75xn	287	18	of	of	IN
cord-018089-m94q75xn	287	19	influenza	influenza	NN
cord-018089-m94q75xn	287	20	virus	virus	NN
cord-018089-m94q75xn	287	21	hemagglutinin	hemagglutinin	NNS
cord-018089-m94q75xn	287	22	expressed	express	VBN
cord-018089-m94q75xn	287	23	in	in	IN
cord-018089-m94q75xn	287	24	mammalian	mammalian	JJ
cord-018089-m94q75xn	287	25	cells	cell	NNS
cord-018089-m94q75xn	287	26	Reverse	reverse	VBP
cord-018089-m94q75xn	287	27	genetics	genetics	NN
cord-018089-m94q75xn	287	28	provides	provide	VBZ
cord-018089-m94q75xn	287	29	direct	direct	JJ
cord-018089-m94q75xn	287	30	evidence	evidence	NN
cord-018089-m94q75xn	287	31	for	for	IN
cord-018089-m94q75xn	287	32	a	a	DT
cord-018089-m94q75xn	287	33	correlation	correlation	NN
cord-018089-m94q75xn	287	34	of	of	IN
cord-018089-m94q75xn	287	35	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	287	36	cleavability	cleavability	NN
cord-018089-m94q75xn	287	37	and	and	CC
cord-018089-m94q75xn	287	38	virulence	virulence	NN
cord-018089-m94q75xn	287	39	of	of	IN
cord-018089-m94q75xn	287	40	an	an	DT
cord-018089-m94q75xn	287	41	avian	avian	JJ
cord-018089-m94q75xn	287	42	influenza	influenza	NN
cord-018089-m94q75xn	287	43	A	a	DT
cord-018089-m94q75xn	287	44	virus	virus	NN
cord-018089-m94q75xn	287	45	Survey	Survey	NNP
cord-018089-m94q75xn	287	46	of	of	IN
cord-018089-m94q75xn	287	47	the	the	DT
cord-018089-m94q75xn	287	48	hemagglutinin	hemagglutinin	NN
cord-018089-m94q75xn	287	49	(	(	-LRB-
cord-018089-m94q75xn	287	50	HA	HA	NNP
cord-018089-m94q75xn	287	51	)	)	-RRB-
cord-018089-m94q75xn	287	52	cleavage	cleavage	NN
cord-018089-m94q75xn	287	53	site	site	NN
cord-018089-m94q75xn	287	54	sequence	sequence	NN
cord-018089-m94q75xn	287	55	of	of	IN
cord-018089-m94q75xn	287	56	H5	H5	NNP
cord-018089-m94q75xn	287	57	and	and	CC
cord-018089-m94q75xn	287	58	H7	H7	NNP
cord-018089-m94q75xn	287	59	avian	avian	JJ
cord-018089-m94q75xn	287	60	influenza	influenza	NN
cord-018089-m94q75xn	287	61	viruses	virus	NNS
cord-018089-m94q75xn	287	62	:	:	:
cord-018089-m94q75xn	287	63	amino	amino	NN
cord-018089-m94q75xn	287	64	acid	acid	NN
cord-018089-m94q75xn	287	65	sequence	sequence	NN
cord-018089-m94q75xn	287	66	at	at	IN
cord-018089-m94q75xn	287	67	the	the	DT
cord-018089-m94q75xn	287	68	HA	HA	NNP
cord-018089-m94q75xn	287	69	cleavage	cleavage	NN
cord-018089-m94q75xn	287	70	site	site	NN
cord-018089-m94q75xn	287	71	as	as	IN
cord-018089-m94q75xn	287	72	a	a	DT
cord-018089-m94q75xn	287	73	marker	marker	NN
cord-018089-m94q75xn	287	74	of	of	IN
cord-018089-m94q75xn	287	75	pathogenicity	pathogenicity	NN
cord-018089-m94q75xn	287	76	potential	potential	JJ
cord-018089-m94q75xn	288	1	In	in	IN
cord-018089-m94q75xn	288	2	vitro	vitro	FW
cord-018089-m94q75xn	288	3	and	and	CC
cord-018089-m94q75xn	288	4	in	in	IN
cord-018089-m94q75xn	288	5	vivo	vivo	NN
cord-018089-m94q75xn	288	6	characterization	characterization	NN
cord-018089-m94q75xn	288	7	of	of	IN
cord-018089-m94q75xn	288	8	new	new	JJ
cord-018089-m94q75xn	288	9	swine	swine	NN
cord-018089-m94q75xn	288	10	-	-	HYPH
cord-018089-m94q75xn	288	11	origin	origin	NN
cord-018089-m94q75xn	288	12	H1N1	H1N1	NNP
cord-018089-m94q75xn	288	13	influenza	influenza	NN
cord-018089-m94q75xn	288	14	viruses	viruse	VBZ
cord-018089-m94q75xn	288	15	Influenza	Influenza	NNP
cord-018089-m94q75xn	288	16	seasonality	seasonality	NN
cord-018089-m94q75xn	288	17	:	:	:
cord-018089-m94q75xn	288	18	underlying	underlie	VBG
cord-018089-m94q75xn	288	19	causes	cause	NNS
cord-018089-m94q75xn	288	20	and	and	CC
cord-018089-m94q75xn	288	21	modeling	model	VBG
cord-018089-m94q75xn	288	22	theories	theory	NNS
cord-018089-m94q75xn	289	1	Seasonal	seasonal	JJ
cord-018089-m94q75xn	289	2	dynamics	dynamic	NNS
cord-018089-m94q75xn	289	3	of	of	IN
cord-018089-m94q75xn	289	4	recurrent	recurrent	JJ
cord-018089-m94q75xn	289	5	epidemics	epidemic	NNS
cord-018089-m94q75xn	289	6	Review	Review	NNP
cord-018089-m94q75xn	289	7	of	of	IN
cord-018089-m94q75xn	289	8	aerosol	aerosol	NN
cord-018089-m94q75xn	289	9	transmission	transmission	NN
cord-018089-m94q75xn	289	10	of	of	IN
cord-018089-m94q75xn	289	11	influenza	influenza	NN
cord-018089-m94q75xn	289	12	A	a	DT
cord-018089-m94q75xn	289	13	virus	virus	NN
cord-018089-m94q75xn	289	14	Transmission	transmission	NN
cord-018089-m94q75xn	289	15	of	of	IN
cord-018089-m94q75xn	289	16	influenza	influenza	NN
cord-018089-m94q75xn	289	17	A	a	NN
cord-018089-m94q75xn	289	18	in	in	IN
cord-018089-m94q75xn	289	19	human	human	JJ
cord-018089-m94q75xn	289	20	beings	being	NNS
cord-018089-m94q75xn	290	1	The	the	DT
cord-018089-m94q75xn	290	2	guinea	guinea	NN
cord-018089-m94q75xn	290	3	pig	pig	NN
cord-018089-m94q75xn	290	4	as	as	IN
cord-018089-m94q75xn	290	5	a	a	DT
cord-018089-m94q75xn	290	6	transmission	transmission	NN
cord-018089-m94q75xn	290	7	model	model	NN
cord-018089-m94q75xn	290	8	for	for	IN
cord-018089-m94q75xn	290	9	human	human	JJ
cord-018089-m94q75xn	290	10	influenza	influenza	NN
cord-018089-m94q75xn	290	11	viruses	virus	NNS
cord-018089-m94q75xn	290	12	Transmission	Transmission	NNP
cord-018089-m94q75xn	290	13	of	of	IN
cord-018089-m94q75xn	290	14	influenza	influenza	NN
cord-018089-m94q75xn	290	15	virus	virus	NN
cord-018089-m94q75xn	290	16	via	via	IN
cord-018089-m94q75xn	290	17	aerosols	aerosol	NNS
cord-018089-m94q75xn	290	18	and	and	CC
cord-018089-m94q75xn	290	19	fomites	fomite	NNS
cord-018089-m94q75xn	290	20	in	in	IN
cord-018089-m94q75xn	290	21	the	the	DT
cord-018089-m94q75xn	290	22	guinea	guinea	NN
cord-018089-m94q75xn	290	23	pig	pig	NN
cord-018089-m94q75xn	290	24	model	model	NN
cord-018089-m94q75xn	291	1	Influenza	influenza	NN
cord-018089-m94q75xn	291	2	virus	virus	NN
cord-018089-m94q75xn	291	3	transmission	transmission	NN
cord-018089-m94q75xn	291	4	is	be	VBZ
cord-018089-m94q75xn	291	5	dependent	dependent	JJ
cord-018089-m94q75xn	291	6	on	on	IN
cord-018089-m94q75xn	291	7	relative	relative	JJ
cord-018089-m94q75xn	291	8	humidity	humidity	NN
cord-018089-m94q75xn	291	9	and	and	CC
cord-018089-m94q75xn	291	10	temperature	temperature	NN
cord-018089-m94q75xn	291	11	High	high	JJ
cord-018089-m94q75xn	291	12	temperature	temperature	NN
cord-018089-m94q75xn	291	13	(	(	-LRB-
cord-018089-m94q75xn	291	14	30	30	CD
cord-018089-m94q75xn	291	15	C	c	NN
cord-018089-m94q75xn	291	16	)	)	-RRB-
cord-018089-m94q75xn	291	17	blocks	block	VBZ
cord-018089-m94q75xn	291	18	aerosol	aerosol	NN
cord-018089-m94q75xn	291	19	but	but	CC
cord-018089-m94q75xn	291	20	not	not	RB
cord-018089-m94q75xn	291	21	contact	contact	VB
cord-018089-m94q75xn	291	22	transmission	transmission	NN
cord-018089-m94q75xn	291	23	of	of	IN
cord-018089-m94q75xn	291	24	influenza	influenza	NN
cord-018089-m94q75xn	291	25	virus	virus	NN
cord-018089-m94q75xn	291	26	Blocking	block	VBG
cord-018089-m94q75xn	291	27	interhost	interhost	NN
cord-018089-m94q75xn	291	28	transmission	transmission	NN
cord-018089-m94q75xn	291	29	of	of	IN
cord-018089-m94q75xn	291	30	influenza	influenza	NN
cord-018089-m94q75xn	291	31	virus	virus	NN
cord-018089-m94q75xn	291	32	by	by	IN
cord-018089-m94q75xn	291	33	vaccination	vaccination	NN
cord-018089-m94q75xn	291	34	in	in	IN
cord-018089-m94q75xn	291	35	the	the	DT
cord-018089-m94q75xn	291	36	guinea	guinea	NN
cord-018089-m94q75xn	291	37	pig	pig	NN
cord-018089-m94q75xn	291	38	model	model	NN
cord-018089-m94q75xn	291	39	Acknowledgments	acknowledgment	NNS
cord-018089-m94q75xn	292	1	The	the	DT
cord-018089-m94q75xn	292	2	work	work	NN
cord-018089-m94q75xn	292	3	completed	complete	VBN
cord-018089-m94q75xn	292	4	in	in	IN
cord-018089-m94q75xn	292	5	this	this	DT
cord-018089-m94q75xn	292	6	laboratory	laboratory	NN
cord-018089-m94q75xn	292	7	was	be	VBD
cord-018089-m94q75xn	292	8	partially	partially	RB
cord-018089-m94q75xn	292	9	supported	support	VBN
cord-018089-m94q75xn	292	10	by	by	IN
cord-018089-m94q75xn	292	11	the	the	DT
cord-018089-m94q75xn	292	12	W.M.	W.M.	NNP
cord-018089-m94q75xn	292	13	Keck	Keck	NNP
cord-018089-m94q75xn	292	14	Foundation	Foundation	NNP
cord-018089-m94q75xn	292	15	,	,	,
cord-018089-m94q75xn	292	16	National	National	NNP
cord-018089-m94q75xn	292	17	Institutes	Institutes	NNPS
cord-018089-m94q75xn	292	18	of	of	IN
cord-018089-m94q75xn	292	19	Health	Health	NNP
cord-018089-m94q75xn	292	20	grants	grant	VBZ
cord-018089-m94q75xn	292	21	P01	P01	NNP
cord-018089-m94q75xn	292	22	AI158113	AI158113	NNP
cord-018089-m94q75xn	292	23	,	,	,
cord-018089-m94q75xn	292	24	the	the	DT
cord-018089-m94q75xn	292	25	Northeast	Northeast	NNP
cord-018089-m94q75xn	292	26	Biodefense	Biodefense	NNP
cord-018089-m94q75xn	292	27	Center	Center	NNP
cord-018089-m94q75xn	292	28	U54	U54	NNP
cord-018089-m94q75xn	292	29	AI057158	AI057158	NNP
cord-018089-m94q75xn	292	30	,	,	,
cord-018089-m94q75xn	292	31	the	the	DT
cord-018089-m94q75xn	292	32	Center	Center	NNP
cord-018089-m94q75xn	292	33	for	for	IN
cord-018089-m94q75xn	292	34	Investigating	investigate	VBG
cord-018089-m94q75xn	292	35	Viral	Viral	NNP
cord-018089-m94q75xn	292	36	Immunity	Immunity	NNP
cord-018089-m94q75xn	292	37	and	and	CC
cord-018089-m94q75xn	292	38	Antagonism	Antagonism	NNP
cord-018089-m94q75xn	292	39	(	(	-LRB-
cord-018089-m94q75xn	292	40	CIVIA	CIVIA	NNP
cord-018089-m94q75xn	292	41	)	)	-RRB-
cord-018089-m94q75xn	293	1	U19	U19	NNP
cord-018089-m94q75xn	293	2	AI62623	AI62623	NNS
cord-018089-m94q75xn	293	3	.	.	.
cord-018089-m94q75xn	294	1	S.M.	S.M.	NNP
cord-018089-m94q75xn	294	2	is	be	VBZ
cord-018089-m94q75xn	294	3	grateful	grateful	JJ
cord-018089-m94q75xn	294	4	for	for	IN
cord-018089-m94q75xn	294	5	the	the	DT
cord-018089-m94q75xn	294	6	Ruth	Ruth	NNP
cord-018089-m94q75xn	294	7	L.	L.	NNP
cord-018089-m94q75xn	294	8	Kirschstein	Kirschstein	NNP
cord-018089-m94q75xn	294	9	Physician	Physician	NNP
cord-018089-m94q75xn	294	10	Scientist	Scientist	NNP
cord-018089-m94q75xn	294	11	Research	Research	NNP
cord-018089-m94q75xn	294	12	Training	Training	NNP
cord-018089-m94q75xn	294	13	in	in	IN
cord-018089-m94q75xn	294	14	Pathogenesis	Pathogenesis	NNP
cord-018089-m94q75xn	294	15	of	of	IN
cord-018089-m94q75xn	294	16	Viral	Viral	NNP
cord-018089-m94q75xn	294	17	Diseases	Diseases	NNPS
cord-018089-m94q75xn	294	18	Award	Award	NNP
cord-018089-m94q75xn	294	19	(	(	-LRB-
cord-018089-m94q75xn	294	20	5T32A1007623	5t32a1007623	CD
cord-018089-m94q75xn	294	21	-	-	HYPH
cord-018089-m94q75xn	294	22	07	07	CD
cord-018089-m94q75xn	294	23	)	)	-RRB-
cord-018089-m94q75xn	294	24	and	and	CC
cord-018089-m94q75xn	294	25	support	support	NN
cord-018089-m94q75xn	294	26	from	from	IN
cord-018089-m94q75xn	294	27	Sunnybrook	Sunnybrook	NNP
cord-018089-m94q75xn	294	28	Health	Health	NNP
cord-018089-m94q75xn	294	29	Sciences	Sciences	NNPS
cord-018089-m94q75xn	294	30	Center	Center	NNP
cord-018089-m94q75xn	294	31	,	,	,
cord-018089-m94q75xn	294	32	Toronto	Toronto	NNP
cord-018089-m94q75xn	294	33	,	,	,
cord-018089-m94q75xn	294	34	ON	ON	NNP
cord-018089-m94q75xn	294	35	,	,	,
cord-018089-m94q75xn	294	36	Canada	Canada	NNP
cord-018089-m94q75xn	294	37	.	.	.