id	sid	tid	token	lemma	pos
cord-252443-lclxrwcm	1	1	key	key	JJ
cord-252443-lclxrwcm	1	2	:	:	:
cord-252443-lclxrwcm	1	3	cord-252443-lclxrwcm	cord-252443-lclxrwcm	NNP
cord-252443-lclxrwcm	1	4	authors	author	NNS
cord-252443-lclxrwcm	1	5	:	:	:
cord-252443-lclxrwcm	1	6	Lambe	Lambe	NNP
cord-252443-lclxrwcm	1	7	,	,	,
cord-252443-lclxrwcm	1	8	Teresa	Teresa	NNP
cord-252443-lclxrwcm	1	9	title	title	NN
cord-252443-lclxrwcm	1	10	:	:	:
cord-252443-lclxrwcm	1	11	Novel	Novel	NNP
cord-252443-lclxrwcm	1	12	Viral	Viral	NNP
cord-252443-lclxrwcm	1	13	Vectored	vectore	VBN
cord-252443-lclxrwcm	1	14	Vaccines	Vaccines	NNPS
cord-252443-lclxrwcm	1	15	for	for	IN
cord-252443-lclxrwcm	1	16	the	the	DT
cord-252443-lclxrwcm	1	17	Prevention	Prevention	NNP
cord-252443-lclxrwcm	1	18	of	of	IN
cord-252443-lclxrwcm	1	19	Influenza	Influenza	NNP
cord-252443-lclxrwcm	1	20	date	date	NN
cord-252443-lclxrwcm	1	21	:	:	:
cord-252443-lclxrwcm	1	22	2012	2012	CD
cord-252443-lclxrwcm	1	23	-	-	HYPH
cord-252443-lclxrwcm	1	24	06	06	CD
cord-252443-lclxrwcm	1	25	-	-	SYM
cord-252443-lclxrwcm	1	26	19	19	CD
cord-252443-lclxrwcm	1	27	journal	journal	NN
cord-252443-lclxrwcm	1	28	:	:	:
cord-252443-lclxrwcm	1	29	Molecular	molecular	JJ
cord-252443-lclxrwcm	1	30	Medicine	medicine	NN
cord-252443-lclxrwcm	1	31	DOI	doi	NN
cord-252443-lclxrwcm	1	32	:	:	:
cord-252443-lclxrwcm	1	33	10.2119/	10.2119/	CD
cord-252443-lclxrwcm	2	1	molmed.2012.00147	molmed.2012.00147	NNP
cord-252443-lclxrwcm	2	2	sha	sha	NNP
cord-252443-lclxrwcm	2	3	:	:	:
cord-252443-lclxrwcm	3	1	bbcfbfc9f70250c918a6d75a049914544dc6ee3f	bbcfbfc9f70250c918a6d75a049914544dc6ee3f	NNP
cord-252443-lclxrwcm	3	2	doc_id	doc_id	CD
cord-252443-lclxrwcm	3	3	:	:	:
cord-252443-lclxrwcm	3	4	252443	252443	CD
cord-252443-lclxrwcm	3	5	cord_uid	cord_uid	NNS
cord-252443-lclxrwcm	3	6	:	:	:
cord-252443-lclxrwcm	4	1	lclxrwcm	lclxrwcm	NNP
cord-252443-lclxrwcm	4	2	Influenza	Influenza	NNP
cord-252443-lclxrwcm	4	3	represents	represent	VBZ
cord-252443-lclxrwcm	4	4	a	a	DT
cord-252443-lclxrwcm	4	5	substantial	substantial	JJ
cord-252443-lclxrwcm	4	6	global	global	JJ
cord-252443-lclxrwcm	4	7	healthcare	healthcare	NN
cord-252443-lclxrwcm	4	8	burden	burden	NN
cord-252443-lclxrwcm	4	9	,	,	,
cord-252443-lclxrwcm	4	10	with	with	IN
cord-252443-lclxrwcm	4	11	annual	annual	JJ
cord-252443-lclxrwcm	4	12	epidemics	epidemic	NNS
cord-252443-lclxrwcm	4	13	resulting	result	VBG
cord-252443-lclxrwcm	4	14	in	in	IN
cord-252443-lclxrwcm	4	15	3–5	3–5	CD
cord-252443-lclxrwcm	4	16	million	million	CD
cord-252443-lclxrwcm	4	17	cases	case	NNS
cord-252443-lclxrwcm	4	18	of	of	IN
cord-252443-lclxrwcm	4	19	severe	severe	JJ
cord-252443-lclxrwcm	4	20	illness	illness	NN
cord-252443-lclxrwcm	4	21	with	with	IN
cord-252443-lclxrwcm	4	22	a	a	DT
cord-252443-lclxrwcm	4	23	significant	significant	JJ
cord-252443-lclxrwcm	4	24	associated	associate	VBN
cord-252443-lclxrwcm	4	25	mortality	mortality	NN
cord-252443-lclxrwcm	4	26	.	.	.
cord-252443-lclxrwcm	5	1	In	in	IN
cord-252443-lclxrwcm	5	2	addition	addition	NN
cord-252443-lclxrwcm	5	3	,	,	,
cord-252443-lclxrwcm	5	4	the	the	DT
cord-252443-lclxrwcm	5	5	risk	risk	NN
cord-252443-lclxrwcm	5	6	of	of	IN
cord-252443-lclxrwcm	5	7	a	a	DT
cord-252443-lclxrwcm	5	8	virulent	virulent	JJ
cord-252443-lclxrwcm	5	9	and	and	CC
cord-252443-lclxrwcm	5	10	lethal	lethal	JJ
cord-252443-lclxrwcm	5	11	influenza	influenza	NN
cord-252443-lclxrwcm	5	12	pandemic	pandemic	NN
cord-252443-lclxrwcm	5	13	has	have	VBZ
cord-252443-lclxrwcm	5	14	generated	generate	VBN
cord-252443-lclxrwcm	5	15	widespread	widespread	JJ
cord-252443-lclxrwcm	5	16	and	and	CC
cord-252443-lclxrwcm	5	17	warranted	warranted	JJ
cord-252443-lclxrwcm	5	18	concern	concern	NN
cord-252443-lclxrwcm	5	19	.	.	.
cord-252443-lclxrwcm	6	1	Currently	currently	RB
cord-252443-lclxrwcm	6	2	licensed	license	VBN
cord-252443-lclxrwcm	6	3	influenza	influenza	NN
cord-252443-lclxrwcm	6	4	vaccines	vaccine	NNS
cord-252443-lclxrwcm	6	5	are	be	VBP
cord-252443-lclxrwcm	6	6	limited	limit	VBN
cord-252443-lclxrwcm	6	7	in	in	IN
cord-252443-lclxrwcm	6	8	their	-PRON-	PRP$
cord-252443-lclxrwcm	6	9	ability	ability	NN
cord-252443-lclxrwcm	6	10	to	to	TO
cord-252443-lclxrwcm	6	11	induce	induce	VB
cord-252443-lclxrwcm	6	12	efficacious	efficacious	JJ
cord-252443-lclxrwcm	6	13	and	and	CC
cord-252443-lclxrwcm	6	14	long	long	RB
cord-252443-lclxrwcm	6	15	-	-	HYPH
cord-252443-lclxrwcm	6	16	lasting	last	VBG
cord-252443-lclxrwcm	6	17	herd	herd	NN
cord-252443-lclxrwcm	6	18	immunity	immunity	NN
cord-252443-lclxrwcm	6	19	.	.	.
cord-252443-lclxrwcm	7	1	In	in	IN
cord-252443-lclxrwcm	7	2	addition	addition	NN
cord-252443-lclxrwcm	7	3	,	,	,
cord-252443-lclxrwcm	7	4	and	and	CC
cord-252443-lclxrwcm	7	5	as	as	IN
cord-252443-lclxrwcm	7	6	evidenced	evidence	VBN
cord-252443-lclxrwcm	7	7	by	by	IN
cord-252443-lclxrwcm	7	8	the	the	DT
cord-252443-lclxrwcm	7	9	H1N1	H1N1	NNP
cord-252443-lclxrwcm	7	10	pandemic	pandemic	NN
cord-252443-lclxrwcm	7	11	in	in	IN
cord-252443-lclxrwcm	7	12	2009	2009	CD
cord-252443-lclxrwcm	7	13	,	,	,
cord-252443-lclxrwcm	7	14	there	there	EX
cord-252443-lclxrwcm	7	15	can	can	MD
cord-252443-lclxrwcm	7	16	be	be	VB
cord-252443-lclxrwcm	7	17	a	a	DT
cord-252443-lclxrwcm	7	18	significant	significant	JJ
cord-252443-lclxrwcm	7	19	delay	delay	NN
cord-252443-lclxrwcm	7	20	between	between	IN
cord-252443-lclxrwcm	7	21	the	the	DT
cord-252443-lclxrwcm	7	22	emergence	emergence	NN
cord-252443-lclxrwcm	7	23	of	of	IN
cord-252443-lclxrwcm	7	24	a	a	DT
cord-252443-lclxrwcm	7	25	pandemic	pandemic	NN
cord-252443-lclxrwcm	7	26	influenza	influenza	NN
cord-252443-lclxrwcm	7	27	and	and	CC
cord-252443-lclxrwcm	7	28	an	an	DT
cord-252443-lclxrwcm	7	29	effective	effective	JJ
cord-252443-lclxrwcm	7	30	,	,	,
cord-252443-lclxrwcm	7	31	antibody	antibody	NN
cord-252443-lclxrwcm	7	32	-	-	HYPH
cord-252443-lclxrwcm	7	33	inducing	induce	VBG
cord-252443-lclxrwcm	7	34	vaccine	vaccine	NN
cord-252443-lclxrwcm	7	35	.	.	.
cord-252443-lclxrwcm	8	1	There	there	EX
cord-252443-lclxrwcm	8	2	is	be	VBZ
cord-252443-lclxrwcm	8	3	,	,	,
cord-252443-lclxrwcm	8	4	therefore	therefore	RB
cord-252443-lclxrwcm	8	5	,	,	,
cord-252443-lclxrwcm	8	6	a	a	DT
cord-252443-lclxrwcm	8	7	continued	continue	VBN
cord-252443-lclxrwcm	8	8	need	need	NN
cord-252443-lclxrwcm	8	9	for	for	IN
cord-252443-lclxrwcm	8	10	new	new	JJ
cord-252443-lclxrwcm	8	11	,	,	,
cord-252443-lclxrwcm	8	12	efficacious	efficacious	JJ
cord-252443-lclxrwcm	8	13	vaccines	vaccine	NNS
cord-252443-lclxrwcm	8	14	conferring	confer	VBG
cord-252443-lclxrwcm	8	15	cross	cross	JJ
cord-252443-lclxrwcm	8	16	-	-	JJ
cord-252443-lclxrwcm	8	17	clade	clade	JJ
cord-252443-lclxrwcm	8	18	protection	protection	NN
cord-252443-lclxrwcm	8	19	—	—	:
cord-252443-lclxrwcm	8	20	obviating	obviate	VBG
cord-252443-lclxrwcm	8	21	the	the	DT
cord-252443-lclxrwcm	8	22	need	need	NN
cord-252443-lclxrwcm	8	23	for	for	IN
cord-252443-lclxrwcm	8	24	biannual	biannual	JJ
cord-252443-lclxrwcm	8	25	reformulation	reformulation	NN
cord-252443-lclxrwcm	8	26	of	of	IN
cord-252443-lclxrwcm	8	27	seasonal	seasonal	JJ
cord-252443-lclxrwcm	8	28	influenza	influenza	NN
cord-252443-lclxrwcm	8	29	vaccines	vaccine	NNS
cord-252443-lclxrwcm	8	30	.	.	.
cord-252443-lclxrwcm	9	1	Development	development	NN
cord-252443-lclxrwcm	9	2	of	of	IN
cord-252443-lclxrwcm	9	3	such	such	PDT
cord-252443-lclxrwcm	9	4	a	a	DT
cord-252443-lclxrwcm	9	5	vaccine	vaccine	NN
cord-252443-lclxrwcm	9	6	would	would	MD
cord-252443-lclxrwcm	9	7	yield	yield	VB
cord-252443-lclxrwcm	9	8	enormous	enormous	JJ
cord-252443-lclxrwcm	9	9	health	health	NN
cord-252443-lclxrwcm	9	10	benefits	benefit	NNS
cord-252443-lclxrwcm	9	11	to	to	IN
cord-252443-lclxrwcm	9	12	society	society	NN
cord-252443-lclxrwcm	9	13	and	and	CC
cord-252443-lclxrwcm	9	14	also	also	RB
cord-252443-lclxrwcm	9	15	greatly	greatly	RB
cord-252443-lclxrwcm	9	16	reduce	reduce	VB
cord-252443-lclxrwcm	9	17	the	the	DT
cord-252443-lclxrwcm	9	18	associated	associate	VBN
cord-252443-lclxrwcm	9	19	global	global	JJ
cord-252443-lclxrwcm	9	20	healthcare	healthcare	NN
cord-252443-lclxrwcm	9	21	burden	burden	NN
cord-252443-lclxrwcm	9	22	.	.	.
cord-252443-lclxrwcm	10	1	There	there	EX
cord-252443-lclxrwcm	10	2	are	be	VBP
cord-252443-lclxrwcm	10	3	a	a	DT
cord-252443-lclxrwcm	10	4	number	number	NN
cord-252443-lclxrwcm	10	5	of	of	IN
cord-252443-lclxrwcm	10	6	alternative	alternative	JJ
cord-252443-lclxrwcm	10	7	influenza	influenza	NN
cord-252443-lclxrwcm	10	8	vaccine	vaccine	NN
cord-252443-lclxrwcm	10	9	technologies	technology	NNS
cord-252443-lclxrwcm	10	10	being	be	VBG
cord-252443-lclxrwcm	10	11	assessed	assess	VBN
cord-252443-lclxrwcm	10	12	both	both	DT
cord-252443-lclxrwcm	10	13	preclinically	preclinically	NN
cord-252443-lclxrwcm	10	14	and	and	CC
cord-252443-lclxrwcm	10	15	clinically	clinically	RB
cord-252443-lclxrwcm	10	16	.	.	.
cord-252443-lclxrwcm	11	1	In	in	IN
cord-252443-lclxrwcm	11	2	this	this	DT
cord-252443-lclxrwcm	11	3	review	review	NN
cord-252443-lclxrwcm	11	4	we	-PRON-	PRP
cord-252443-lclxrwcm	11	5	discuss	discuss	VBP
cord-252443-lclxrwcm	11	6	viral	viral	JJ
cord-252443-lclxrwcm	11	7	vectored	vectore	VBN
cord-252443-lclxrwcm	11	8	vaccines	vaccine	NNS
cord-252443-lclxrwcm	11	9	,	,	,
cord-252443-lclxrwcm	11	10	either	either	CC
cord-252443-lclxrwcm	11	11	recombinant	recombinant	JJ
cord-252443-lclxrwcm	11	12	live	live	RB
cord-252443-lclxrwcm	11	13	-	-	HYPH
cord-252443-lclxrwcm	11	14	attenuated	attenuate	VBN
cord-252443-lclxrwcm	11	15	or	or	CC
cord-252443-lclxrwcm	11	16	replication	replication	NN
cord-252443-lclxrwcm	11	17	-	-	HYPH
cord-252443-lclxrwcm	11	18	deficient	deficient	JJ
cord-252443-lclxrwcm	11	19	viruses	virus	NNS
cord-252443-lclxrwcm	11	20	,	,	,
cord-252443-lclxrwcm	11	21	which	which	WDT
cord-252443-lclxrwcm	11	22	are	be	VBP
cord-252443-lclxrwcm	11	23	current	current	JJ
cord-252443-lclxrwcm	11	24	lead	lead	JJ
cord-252443-lclxrwcm	11	25	candidates	candidate	NNS
cord-252443-lclxrwcm	11	26	for	for	IN
cord-252443-lclxrwcm	11	27	inducing	induce	VBG
cord-252443-lclxrwcm	11	28	efficacious	efficacious	JJ
cord-252443-lclxrwcm	11	29	and	and	CC
cord-252443-lclxrwcm	11	30	long	long	RB
cord-252443-lclxrwcm	11	31	-	-	HYPH
cord-252443-lclxrwcm	11	32	lasting	last	VBG
cord-252443-lclxrwcm	11	33	immunity	immunity	NN
cord-252443-lclxrwcm	11	34	toward	toward	IN
cord-252443-lclxrwcm	11	35	influenza	influenza	NN
cord-252443-lclxrwcm	11	36	viruses	virus	NNS
cord-252443-lclxrwcm	11	37	.	.	.
cord-252443-lclxrwcm	12	1	These	these	DT
cord-252443-lclxrwcm	12	2	alternate	alternate	JJ
cord-252443-lclxrwcm	12	3	influenza	influenza	NN
cord-252443-lclxrwcm	12	4	vaccines	vaccine	NNS
cord-252443-lclxrwcm	12	5	offer	offer	VBP
cord-252443-lclxrwcm	12	6	real	real	JJ
cord-252443-lclxrwcm	12	7	promise	promise	NN
cord-252443-lclxrwcm	12	8	to	to	TO
cord-252443-lclxrwcm	12	9	deliver	deliver	VB
cord-252443-lclxrwcm	12	10	viable	viable	JJ
cord-252443-lclxrwcm	12	11	alternatives	alternative	NNS
cord-252443-lclxrwcm	12	12	to	to	IN
cord-252443-lclxrwcm	12	13	currently	currently	RB
cord-252443-lclxrwcm	12	14	deployed	deploy	VBN
cord-252443-lclxrwcm	12	15	vaccines	vaccine	NNS
cord-252443-lclxrwcm	12	16	and	and	CC
cord-252443-lclxrwcm	12	17	more	more	RBR
cord-252443-lclxrwcm	12	18	importantly	importantly	RB
cord-252443-lclxrwcm	12	19	may	may	MD
cord-252443-lclxrwcm	12	20	confer	confer	VB
cord-252443-lclxrwcm	12	21	long	long	RB
cord-252443-lclxrwcm	12	22	-	-	HYPH
cord-252443-lclxrwcm	12	23	lasting	last	VBG
cord-252443-lclxrwcm	12	24	and	and	CC
cord-252443-lclxrwcm	12	25	universal	universal	JJ
cord-252443-lclxrwcm	12	26	protection	protection	NN
cord-252443-lclxrwcm	12	27	against	against	IN
cord-252443-lclxrwcm	12	28	influenza	influenza	JJ
cord-252443-lclxrwcm	12	29	viral	viral	JJ
cord-252443-lclxrwcm	12	30	infection	infection	NN
cord-252443-lclxrwcm	12	31	.	.	.
cord-252443-lclxrwcm	13	1	Influenza	influenza	NN
cord-252443-lclxrwcm	13	2	epidemics	epidemic	NNS
cord-252443-lclxrwcm	13	3	are	be	VBP
cord-252443-lclxrwcm	13	4	associated	associate	VBN
cord-252443-lclxrwcm	13	5	with	with	IN
cord-252443-lclxrwcm	13	6	a	a	DT
cord-252443-lclxrwcm	13	7	nontrivial	nontrivial	JJ
cord-252443-lclxrwcm	13	8	morbidity	morbidity	NN
cord-252443-lclxrwcm	13	9	and	and	CC
cord-252443-lclxrwcm	13	10	mortality	mortality	NN
cord-252443-lclxrwcm	13	11	;	;	:
cord-252443-lclxrwcm	13	12	up	up	IN
cord-252443-lclxrwcm	13	13	to	to	IN
cord-252443-lclxrwcm	13	14	one	one	CD
cord-252443-lclxrwcm	13	15	billion	billion	CD
cord-252443-lclxrwcm	13	16	infections	infection	NNS
cord-252443-lclxrwcm	13	17	occur	occur	VBP
cord-252443-lclxrwcm	13	18	annually	annually	RB
cord-252443-lclxrwcm	13	19	with	with	IN
cord-252443-lclxrwcm	13	20	upwards	upward	NNS
cord-252443-lclxrwcm	13	21	of	of	IN
cord-252443-lclxrwcm	13	22	a	a	DT
cord-252443-lclxrwcm	13	23	half	half	PDT
cord-252443-lclxrwcm	13	24	a	a	DT
cord-252443-lclxrwcm	13	25	million	million	CD
cord-252443-lclxrwcm	13	26	associated	associate	VBN
cord-252443-lclxrwcm	13	27	deaths	death	NNS
cord-252443-lclxrwcm	13	28	(	(	-LRB-
cord-252443-lclxrwcm	13	29	1	1	CD
cord-252443-lclxrwcm	13	30	,	,	,
cord-252443-lclxrwcm	13	31	2	2	CD
cord-252443-lclxrwcm	13	32	)	)	-RRB-
cord-252443-lclxrwcm	13	33	.	.	.
cord-252443-lclxrwcm	14	1	The	the	DT
cord-252443-lclxrwcm	14	2	mortality	mortality	NN
cord-252443-lclxrwcm	14	3	associated	associate	VBN
cord-252443-lclxrwcm	14	4	with	with	IN
cord-252443-lclxrwcm	14	5	the	the	DT
cord-252443-lclxrwcm	14	6	first	first	JJ
cord-252443-lclxrwcm	14	7	influenza	influenza	NN
cord-252443-lclxrwcm	14	8	pandemic	pandemic	NN
cord-252443-lclxrwcm	14	9	of	of	IN
cord-252443-lclxrwcm	14	10	the	the	DT
cord-252443-lclxrwcm	14	11	21st	21st	JJ
cord-252443-lclxrwcm	14	12	century	century	NN
cord-252443-lclxrwcm	14	13	,	,	,
cord-252443-lclxrwcm	14	14	caused	cause	VBN
cord-252443-lclxrwcm	14	15	by	by	IN
cord-252443-lclxrwcm	14	16	the	the	DT
cord-252443-lclxrwcm	14	17	swine	swine	NN
cord-252443-lclxrwcm	14	18	-	-	HYPH
cord-252443-lclxrwcm	14	19	origin	origin	NN
cord-252443-lclxrwcm	14	20	influenza	influenza	NN
cord-252443-lclxrwcm	14	21	A	a	DT
cord-252443-lclxrwcm	14	22	H1N1/09	h1n1/09	JJ
cord-252443-lclxrwcm	14	23	virus	virus	NN
cord-252443-lclxrwcm	14	24	,	,	,
cord-252443-lclxrwcm	14	25	was	be	VBD
cord-252443-lclxrwcm	14	26	not	not	RB
cord-252443-lclxrwcm	14	27	as	as	RB
cord-252443-lclxrwcm	14	28	high	high	JJ
cord-252443-lclxrwcm	14	29	as	as	IN
cord-252443-lclxrwcm	14	30	first	first	RB
cord-252443-lclxrwcm	14	31	anticipated	anticipate	VBN
cord-252443-lclxrwcm	14	32	,	,	,
cord-252443-lclxrwcm	14	33	nor	nor	CC
cord-252443-lclxrwcm	14	34	when	when	WRB
cord-252443-lclxrwcm	14	35	compared	compare	VBN
cord-252443-lclxrwcm	14	36	with	with	IN
cord-252443-lclxrwcm	14	37	the	the	DT
cord-252443-lclxrwcm	14	38	1918	1918	CD
cord-252443-lclxrwcm	14	39	pandemic	pandemic	NN
cord-252443-lclxrwcm	14	40	,	,	,
cord-252443-lclxrwcm	14	41	which	which	WDT
cord-252443-lclxrwcm	14	42	claimed	claim	VBD
cord-252443-lclxrwcm	14	43	an	an	DT
cord-252443-lclxrwcm	14	44	estimated	estimate	VBN
cord-252443-lclxrwcm	14	45	15	15	CD
cord-252443-lclxrwcm	14	46	-	-	SYM
cord-252443-lclxrwcm	14	47	50	50	CD
cord-252443-lclxrwcm	14	48	million	million	CD
cord-252443-lclxrwcm	14	49	lives	life	NNS
cord-252443-lclxrwcm	14	50	worldwide	worldwide	RB
cord-252443-lclxrwcm	14	51	(	(	-LRB-
cord-252443-lclxrwcm	14	52	3	3	CD
cord-252443-lclxrwcm	14	53	)	)	-RRB-
cord-252443-lclxrwcm	14	54	.	.	.
cord-252443-lclxrwcm	15	1	However	however	RB
cord-252443-lclxrwcm	15	2	,	,	,
cord-252443-lclxrwcm	15	3	the	the	DT
cord-252443-lclxrwcm	15	4	continued	continued	JJ
cord-252443-lclxrwcm	15	5	risk	risk	NN
cord-252443-lclxrwcm	15	6	of	of	IN
cord-252443-lclxrwcm	15	7	a	a	DT
cord-252443-lclxrwcm	15	8	lethal	lethal	JJ
cord-252443-lclxrwcm	15	9	and	and	CC
cord-252443-lclxrwcm	15	10	transmissible	transmissible	JJ
cord-252443-lclxrwcm	15	11	influenza	influenza	NN
cord-252443-lclxrwcm	15	12	pandemic	pandemic	NN
cord-252443-lclxrwcm	15	13	has	have	VBZ
cord-252443-lclxrwcm	15	14	generated	generate	VBN
cord-252443-lclxrwcm	15	15	widespread	widespread	JJ
cord-252443-lclxrwcm	15	16	and	and	CC
cord-252443-lclxrwcm	15	17	warranted	warranted	JJ
cord-252443-lclxrwcm	15	18	concern	concern	NN
cord-252443-lclxrwcm	15	19	(	(	-LRB-
cord-252443-lclxrwcm	15	20	4	4	CD
cord-252443-lclxrwcm	15	21	)	)	-RRB-
cord-252443-lclxrwcm	15	22	.	.	.
cord-252443-lclxrwcm	16	1	There	there	EX
cord-252443-lclxrwcm	16	2	are	be	VBP
cord-252443-lclxrwcm	16	3	three	three	CD
cord-252443-lclxrwcm	16	4	genera	genus	NNS
cord-252443-lclxrwcm	16	5	of	of	IN
cord-252443-lclxrwcm	16	6	influenza	influenza	NN
cord-252443-lclxrwcm	16	7	virus	virus	NN
cord-252443-lclxrwcm	16	8	that	that	WDT
cord-252443-lclxrwcm	16	9	infect	infect	VBP
cord-252443-lclxrwcm	16	10	humans	human	NNS
cord-252443-lclxrwcm	16	11	,	,	,
cord-252443-lclxrwcm	16	12	influenza	influenza	NN
cord-252443-lclxrwcm	16	13	A	a	NN
cord-252443-lclxrwcm	16	14	,	,	,
cord-252443-lclxrwcm	16	15	B	b	NN
cord-252443-lclxrwcm	16	16	and	and	CC
cord-252443-lclxrwcm	16	17	C	c	NN
cord-252443-lclxrwcm	16	18	viruses	virus	NNS
cord-252443-lclxrwcm	16	19	.	.	.
cord-252443-lclxrwcm	17	1	Type	type	VB
cord-252443-lclxrwcm	17	2	A	a	DT
cord-252443-lclxrwcm	17	3	influenza	influenza	NN
cord-252443-lclxrwcm	17	4	viruses	virus	NNS
cord-252443-lclxrwcm	17	5	are	be	VBP
cord-252443-lclxrwcm	17	6	the	the	DT
cord-252443-lclxrwcm	17	7	most	most	RBS
cord-252443-lclxrwcm	17	8	virulent	virulent	JJ
cord-252443-lclxrwcm	17	9	influenza	influenza	NN
cord-252443-lclxrwcm	17	10	viruses	virus	NNS
cord-252443-lclxrwcm	17	11	infecting	infect	VBG
cord-252443-lclxrwcm	17	12	humans	human	NNS
cord-252443-lclxrwcm	17	13	and	and	CC
cord-252443-lclxrwcm	17	14	can	can	MD
cord-252443-lclxrwcm	17	15	be	be	VB
cord-252443-lclxrwcm	17	16	divided	divide	VBN
cord-252443-lclxrwcm	17	17	into	into	IN
cord-252443-lclxrwcm	17	18	different	different	JJ
cord-252443-lclxrwcm	17	19	subtypes	subtype	NNS
cord-252443-lclxrwcm	17	20	on	on	IN
cord-252443-lclxrwcm	17	21	the	the	DT
cord-252443-lclxrwcm	17	22	basis	basis	NN
cord-252443-lclxrwcm	17	23	of	of	IN
cord-252443-lclxrwcm	17	24	the	the	DT
cord-252443-lclxrwcm	17	25	antigenic	antigenic	JJ
cord-252443-lclxrwcm	17	26	properties	property	NNS
cord-252443-lclxrwcm	17	27	of	of	IN
cord-252443-lclxrwcm	17	28	the	the	DT
cord-252443-lclxrwcm	17	29	virion	virion	NN
cord-252443-lclxrwcm	17	30	surface	surface	NN
cord-252443-lclxrwcm	17	31	proteins	protein	NNS
cord-252443-lclxrwcm	17	32	,	,	,
cord-252443-lclxrwcm	17	33	hemagglutinin	hemagglutinin	NN
cord-252443-lclxrwcm	17	34	(	(	-LRB-
cord-252443-lclxrwcm	17	35	HA	HA	NNP
cord-252443-lclxrwcm	17	36	)	)	-RRB-
cord-252443-lclxrwcm	17	37	and	and	CC
cord-252443-lclxrwcm	17	38	neuraminidase	neuraminidase	NN
cord-252443-lclxrwcm	17	39	(	(	-LRB-
cord-252443-lclxrwcm	17	40	NA	NA	NNP
cord-252443-lclxrwcm	17	41	)	)	-RRB-
cord-252443-lclxrwcm	17	42	(	(	-LRB-
cord-252443-lclxrwcm	17	43	5	5	CD
cord-252443-lclxrwcm	17	44	,	,	,
cord-252443-lclxrwcm	17	45	6	6	CD
cord-252443-lclxrwcm	17	46	)	)	-RRB-
cord-252443-lclxrwcm	17	47	.	.	.
cord-252443-lclxrwcm	18	1	Currently	currently	RB
cord-252443-lclxrwcm	18	2	there	there	EX
cord-252443-lclxrwcm	18	3	are	be	VBP
cord-252443-lclxrwcm	18	4	17	17	CD
cord-252443-lclxrwcm	18	5	HA	HA	NNP
cord-252443-lclxrwcm	18	6	subtypes	subtype	NNS
cord-252443-lclxrwcm	18	7	and	and	CC
cord-252443-lclxrwcm	18	8	9	9	CD
cord-252443-lclxrwcm	18	9	NA	NA	NNP
cord-252443-lclxrwcm	18	10	subtypes	subtype	NNS
cord-252443-lclxrwcm	18	11	identified	identify	VBN
cord-252443-lclxrwcm	18	12	,	,	,
cord-252443-lclxrwcm	18	13	and	and	CC
cord-252443-lclxrwcm	18	14	most	most	JJS
cord-252443-lclxrwcm	18	15	of	of	IN
cord-252443-lclxrwcm	18	16	the	the	DT
cord-252443-lclxrwcm	18	17	possible	possible	JJ
cord-252443-lclxrwcm	18	18	combinations	combination	NNS
cord-252443-lclxrwcm	18	19	have	have	VBP
cord-252443-lclxrwcm	18	20	been	be	VBN
cord-252443-lclxrwcm	18	21	found	find	VBN
cord-252443-lclxrwcm	18	22	circulating	circulate	VBG
cord-252443-lclxrwcm	18	23	in	in	IN
cord-252443-lclxrwcm	18	24	wild	wild	JJ
cord-252443-lclxrwcm	18	25	birds	bird	NNS
cord-252443-lclxrwcm	18	26	(	(	-LRB-
cord-252443-lclxrwcm	18	27	5	5	CD
cord-252443-lclxrwcm	18	28	)	)	-RRB-
cord-252443-lclxrwcm	18	29	(	(	-LRB-
cord-252443-lclxrwcm	18	30	6	6	LS
cord-252443-lclxrwcm	18	31	)	)	-RRB-
cord-252443-lclxrwcm	18	32	(	(	-LRB-
cord-252443-lclxrwcm	18	33	7	7	CD
cord-252443-lclxrwcm	18	34	)	)	-RRB-
cord-252443-lclxrwcm	18	35	.	.	.
cord-252443-lclxrwcm	19	1	However	however	RB
cord-252443-lclxrwcm	19	2	,	,	,
cord-252443-lclxrwcm	19	3	the	the	DT
cord-252443-lclxrwcm	19	4	majority	majority	NN
cord-252443-lclxrwcm	19	5	of	of	IN
cord-252443-lclxrwcm	19	6	influenza	influenza	NN
cord-252443-lclxrwcm	19	7	in	in	IN
cord-252443-lclxrwcm	19	8	humans	human	NNS
cord-252443-lclxrwcm	19	9	is	be	VBZ
cord-252443-lclxrwcm	19	10	caused	cause	VBN
cord-252443-lclxrwcm	19	11	by	by	IN
cord-252443-lclxrwcm	19	12	only	only	RB
cord-252443-lclxrwcm	19	13	three	three	CD
cord-252443-lclxrwcm	19	14	subtypes	subtype	NNS
cord-252443-lclxrwcm	19	15	of	of	IN
cord-252443-lclxrwcm	19	16	HA	HA	NNP
cord-252443-lclxrwcm	19	17	(	(	-LRB-
cord-252443-lclxrwcm	19	18	H1	h1	NN
cord-252443-lclxrwcm	19	19	,	,	,
cord-252443-lclxrwcm	19	20	H2	H2	NNP
cord-252443-lclxrwcm	19	21	and	and	CC
cord-252443-lclxrwcm	19	22	H3	H3	NNP
cord-252443-lclxrwcm	19	23	)	)	-RRB-
cord-252443-lclxrwcm	19	24	and	and	CC
cord-252443-lclxrwcm	19	25	two	two	CD
cord-252443-lclxrwcm	19	26	subtypes	subtype	NNS
cord-252443-lclxrwcm	19	27	of	of	IN
cord-252443-lclxrwcm	19	28	NA	NA	NNP
cord-252443-lclxrwcm	19	29	(	(	-LRB-
cord-252443-lclxrwcm	19	30	N1	N1	NNP
cord-252443-lclxrwcm	19	31	and	and	CC
cord-252443-lclxrwcm	19	32	N2	N2	NNP
cord-252443-lclxrwcm	19	33	)	)	-RRB-
cord-252443-lclxrwcm	19	34	(	(	-LRB-
cord-252443-lclxrwcm	20	1	8)	8)	NNP
cord-252443-lclxrwcm	20	2	.	.	.
cord-252443-lclxrwcm	21	1	Indeed	indeed	RB
cord-252443-lclxrwcm	21	2	,	,	,
cord-252443-lclxrwcm	21	3	recent	recent	JJ
cord-252443-lclxrwcm	21	4	pandemics	pandemic	NNS
cord-252443-lclxrwcm	21	5	have	have	VBP
cord-252443-lclxrwcm	21	6	been	be	VBN
cord-252443-lclxrwcm	21	7	caused	cause	VBN
cord-252443-lclxrwcm	21	8	by	by	IN
cord-252443-lclxrwcm	21	9	three	three	CD
cord-252443-lclxrwcm	21	10	subtypes	subtype	NNS
cord-252443-lclxrwcm	21	11	,	,	,
cord-252443-lclxrwcm	21	12	namely	namely	RB
cord-252443-lclxrwcm	21	13	:	:	:
cord-252443-lclxrwcm	21	14	H1N1	H1N1	NNP
cord-252443-lclxrwcm	21	15	(	(	-LRB-
cord-252443-lclxrwcm	21	16	in	in	IN
cord-252443-lclxrwcm	21	17	1918	1918	CD
cord-252443-lclxrwcm	21	18	and	and	CC
cord-252443-lclxrwcm	21	19	2009	2009	CD
cord-252443-lclxrwcm	21	20	,	,	,
cord-252443-lclxrwcm	21	21	the	the	DT
cord-252443-lclxrwcm	21	22	Spanish	spanish	JJ
cord-252443-lclxrwcm	21	23	and	and	CC
cord-252443-lclxrwcm	21	24	Swine	Swine	NNP
cord-252443-lclxrwcm	21	25	flu	flu	NN
cord-252443-lclxrwcm	21	26	pandemics	pandemic	NNS
cord-252443-lclxrwcm	21	27	,	,	,
cord-252443-lclxrwcm	21	28	respectively	respectively	RB
cord-252443-lclxrwcm	21	29	)	)	-RRB-
cord-252443-lclxrwcm	21	30	,	,	,
cord-252443-lclxrwcm	21	31	H2N2	H2N2	NNP
cord-252443-lclxrwcm	21	32	(	(	-LRB-
cord-252443-lclxrwcm	21	33	in	in	IN
cord-252443-lclxrwcm	21	34	1957	1957	CD
cord-252443-lclxrwcm	21	35	,	,	,
cord-252443-lclxrwcm	21	36	known	know	VBN
cord-252443-lclxrwcm	21	37	as	as	IN
cord-252443-lclxrwcm	21	38	the	the	DT
cord-252443-lclxrwcm	21	39	Asian	asian	JJ
cord-252443-lclxrwcm	21	40	flu	flu	NN
cord-252443-lclxrwcm	21	41	)	)	-RRB-
cord-252443-lclxrwcm	21	42	and	and	CC
cord-252443-lclxrwcm	21	43	H3N2	H3N2	NNP
cord-252443-lclxrwcm	21	44	(	(	-LRB-
cord-252443-lclxrwcm	21	45	in	in	IN
cord-252443-lclxrwcm	21	46	1968	1968	CD
cord-252443-lclxrwcm	21	47	,	,	,
cord-252443-lclxrwcm	21	48	known	know	VBN
cord-252443-lclxrwcm	21	49	as	as	IN
cord-252443-lclxrwcm	21	50	the	the	DT
cord-252443-lclxrwcm	21	51	Hong	Hong	NNP
cord-252443-lclxrwcm	21	52	Kong	Kong	NNP
cord-252443-lclxrwcm	21	53	flu	flu	NN
cord-252443-lclxrwcm	21	54	)	)	-RRB-
cord-252443-lclxrwcm	22	1	(	(	-LRB-
cord-252443-lclxrwcm	22	2	8)	8)	NNP
cord-252443-lclxrwcm	22	3	.	.	.
cord-252443-lclxrwcm	23	1	In	in	IN
cord-252443-lclxrwcm	23	2	contrast	contrast	NN
cord-252443-lclxrwcm	23	3	to	to	IN
cord-252443-lclxrwcm	23	4	influenza	influenza	NN
cord-252443-lclxrwcm	23	5	A	a	DT
cord-252443-lclxrwcm	23	6	viruses	virus	NNS
cord-252443-lclxrwcm	23	7	,	,	,
cord-252443-lclxrwcm	23	8	B	b	NN
cord-252443-lclxrwcm	23	9	viruses	virus	NNS
cord-252443-lclxrwcm	23	10	mutate	mutate	VBP
cord-252443-lclxrwcm	23	11	slowly	slowly	RB
cord-252443-lclxrwcm	23	12	(	(	-LRB-
cord-252443-lclxrwcm	23	13	9	9	CD
cord-252443-lclxrwcm	23	14	)	)	-RRB-
cord-252443-lclxrwcm	23	15	.	.	.
cord-252443-lclxrwcm	24	1	At	at	IN
cord-252443-lclxrwcm	24	2	present	present	JJ
cord-252443-lclxrwcm	24	3	,	,	,
cord-252443-lclxrwcm	24	4	there	there	EX
cord-252443-lclxrwcm	24	5	are	be	VBP
cord-252443-lclxrwcm	24	6	two	two	CD
cord-252443-lclxrwcm	24	7	antigenically	antigenically	RB
cord-252443-lclxrwcm	24	8	distinct	distinct	JJ
cord-252443-lclxrwcm	24	9	type	type	NN
cord-252443-lclxrwcm	24	10	B	b	NN
cord-252443-lclxrwcm	24	11	influenza	influenza	NN
cord-252443-lclxrwcm	24	12	lineages	lineage	NNS
cord-252443-lclxrwcm	24	13	(	(	-LRB-
cord-252443-lclxrwcm	24	14	Victoria	Victoria	NNP
cord-252443-lclxrwcm	24	15	and	and	CC
cord-252443-lclxrwcm	24	16	Yamagata	Yamagata	NNP
cord-252443-lclxrwcm	24	17	)	)	-RRB-
cord-252443-lclxrwcm	24	18	,	,	,
cord-252443-lclxrwcm	24	19	which	which	WDT
cord-252443-lclxrwcm	24	20	are	be	VBP
cord-252443-lclxrwcm	24	21	concurrently	concurrently	RB
cord-252443-lclxrwcm	24	22	circulating	circulate	VBG
cord-252443-lclxrwcm	24	23	(	(	-LRB-
cord-252443-lclxrwcm	24	24	10	10	CD
cord-252443-lclxrwcm	24	25	,	,	,
cord-252443-lclxrwcm	24	26	11	11	CD
cord-252443-lclxrwcm	24	27	)	)	-RRB-
cord-252443-lclxrwcm	24	28	,	,	,
cord-252443-lclxrwcm	24	29	and	and	CC
cord-252443-lclxrwcm	24	30	individuals	individual	NNS
cord-252443-lclxrwcm	24	31	exposed	expose	VBN
cord-252443-lclxrwcm	24	32	to	to	IN
cord-252443-lclxrwcm	24	33	one	one	CD
cord-252443-lclxrwcm	24	34	lineage	lineage	NN
cord-252443-lclxrwcm	24	35	have	have	VBP
cord-252443-lclxrwcm	24	36	limited	limit	VBN
cord-252443-lclxrwcm	24	37	cross	cross	JJ
cord-252443-lclxrwcm	24	38	-	-	JJ
cord-252443-lclxrwcm	24	39	protective	protective	JJ
cord-252443-lclxrwcm	24	40	immunity	immunity	NN
cord-252443-lclxrwcm	24	41	because	because	IN
cord-252443-lclxrwcm	24	42	of	of	IN
cord-252443-lclxrwcm	24	43	antigenic	antigenic	JJ
cord-252443-lclxrwcm	24	44	dissimilarity	dissimilarity	NN
cord-252443-lclxrwcm	24	45	between	between	IN
cord-252443-lclxrwcm	24	46	strains	strain	NNS
cord-252443-lclxrwcm	24	47	(	(	-LRB-
cord-252443-lclxrwcm	24	48	11	11	CD
cord-252443-lclxrwcm	24	49	)	)	-RRB-
cord-252443-lclxrwcm	24	50	.	.	.
cord-252443-lclxrwcm	25	1	The	the	DT
cord-252443-lclxrwcm	25	2	burden	burden	NN
cord-252443-lclxrwcm	25	3	of	of	IN
cord-252443-lclxrwcm	25	4	disease	disease	NN
cord-252443-lclxrwcm	25	5	due	due	IN
cord-252443-lclxrwcm	25	6	to	to	IN
cord-252443-lclxrwcm	25	7	influenza	influenza	NN
cord-252443-lclxrwcm	25	8	B	b	NN
cord-252443-lclxrwcm	25	9	viral	viral	JJ
cord-252443-lclxrwcm	25	10	infection	infection	NN
cord-252443-lclxrwcm	25	11	falls	fall	VBZ
cord-252443-lclxrwcm	25	12	largely	largely	RB
cord-252443-lclxrwcm	25	13	on	on	IN
cord-252443-lclxrwcm	25	14	children	child	NNS
cord-252443-lclxrwcm	25	15	and	and	CC
cord-252443-lclxrwcm	25	16	young	young	JJ
cord-252443-lclxrwcm	25	17	adults	adult	NNS
cord-252443-lclxrwcm	25	18	,	,	,
cord-252443-lclxrwcm	25	19	and	and	CC
cord-252443-lclxrwcm	25	20	this	this	DT
cord-252443-lclxrwcm	25	21	influenza	influenza	NN
cord-252443-lclxrwcm	25	22	virus	virus	NN
cord-252443-lclxrwcm	25	23	causes	cause	VBZ
cord-252443-lclxrwcm	25	24	seasonal	seasonal	JJ
cord-252443-lclxrwcm	25	25	influenza	influenza	NN
cord-252443-lclxrwcm	25	26	epidemics	epidemic	NNS
cord-252443-lclxrwcm	25	27	every	every	DT
cord-252443-lclxrwcm	25	28	2	2	CD
cord-252443-lclxrwcm	25	29	-	-	SYM
cord-252443-lclxrwcm	25	30	4	4	CD
cord-252443-lclxrwcm	25	31	years	year	NNS
cord-252443-lclxrwcm	25	32	(	(	-LRB-
cord-252443-lclxrwcm	25	33	11	11	CD
cord-252443-lclxrwcm	25	34	)	)	-RRB-
cord-252443-lclxrwcm	25	35	.	.	.
cord-252443-lclxrwcm	26	1	By	by	IN
cord-252443-lclxrwcm	26	2	contrast	contrast	NN
cord-252443-lclxrwcm	26	3	,	,	,
cord-252443-lclxrwcm	26	4	influenza	influenza	NN
cord-252443-lclxrwcm	26	5	C	c	NN
cord-252443-lclxrwcm	26	6	virus	virus	NN
cord-252443-lclxrwcm	26	7	,	,	,
cord-252443-lclxrwcm	26	8	although	although	IN
cord-252443-lclxrwcm	26	9	a	a	DT
cord-252443-lclxrwcm	26	10	common	common	JJ
cord-252443-lclxrwcm	26	11	cause	cause	NN
cord-252443-lclxrwcm	26	12	of	of	IN
cord-252443-lclxrwcm	26	13	mild	mild	JJ
cord-252443-lclxrwcm	26	14	upper	upper	JJ
cord-252443-lclxrwcm	26	15	respiratory	respiratory	JJ
cord-252443-lclxrwcm	26	16	illness	illness	NN
cord-252443-lclxrwcm	26	17	,	,	,
cord-252443-lclxrwcm	26	18	rarely	rarely	RB
cord-252443-lclxrwcm	26	19	causes	cause	VBZ
cord-252443-lclxrwcm	26	20	severe	severe	JJ
cord-252443-lclxrwcm	26	21	illness	illness	NN
cord-252443-lclxrwcm	26	22	or	or	CC
cord-252443-lclxrwcm	26	23	local	local	JJ
cord-252443-lclxrwcm	26	24	epidemics	epidemic	NNS
cord-252443-lclxrwcm	26	25	because	because	IN
cord-252443-lclxrwcm	26	26	most	most	JJS
cord-252443-lclxrwcm	26	27	people	people	NNS
cord-252443-lclxrwcm	26	28	acquire	acquire	VBP
cord-252443-lclxrwcm	26	29	protective	protective	JJ
cord-252443-lclxrwcm	26	30	antibodies	antibody	NNS
cord-252443-lclxrwcm	26	31	early	early	RB
cord-252443-lclxrwcm	26	32	in	in	IN
cord-252443-lclxrwcm	26	33	life	life	NN
cord-252443-lclxrwcm	26	34	(	(	-LRB-
cord-252443-lclxrwcm	26	35	12	12	CD
cord-252443-lclxrwcm	26	36	)	)	-RRB-
cord-252443-lclxrwcm	26	37	.	.	.
cord-252443-lclxrwcm	27	1	southern	southern	JJ
cord-252443-lclxrwcm	27	2	hemisphere	hemisphere	NN
cord-252443-lclxrwcm	27	3	.	.	.
cord-252443-lclxrwcm	28	1	Routinely	routinely	RB
cord-252443-lclxrwcm	28	2	,	,	,
cord-252443-lclxrwcm	28	3	formulations	formulation	NNS
cord-252443-lclxrwcm	28	4	contain	contain	VBP
cord-252443-lclxrwcm	28	5	two	two	CD
cord-252443-lclxrwcm	28	6	human	human	JJ
cord-252443-lclxrwcm	28	7	influenza	influenza	NN
cord-252443-lclxrwcm	28	8	A	a	DT
cord-252443-lclxrwcm	28	9	subtypes	subtype	NNS
cord-252443-lclxrwcm	28	10	(	(	-LRB-
cord-252443-lclxrwcm	28	11	H3N2	H3N2	NNP
cord-252443-lclxrwcm	28	12	and	and	CC
cord-252443-lclxrwcm	28	13	H1N1	H1N1	NNP
cord-252443-lclxrwcm	28	14	)	)	-RRB-
cord-252443-lclxrwcm	28	15	and	and	CC
cord-252443-lclxrwcm	28	16	one	one	CD
cord-252443-lclxrwcm	28	17	of	of	IN
cord-252443-lclxrwcm	28	18	the	the	DT
cord-252443-lclxrwcm	28	19	two	two	CD
cord-252443-lclxrwcm	28	20	influenza	influenza	NN
cord-252443-lclxrwcm	28	21	B	b	NN
cord-252443-lclxrwcm	28	22	lineages	lineage	NNS
cord-252443-lclxrwcm	28	23	(	(	-LRB-
cord-252443-lclxrwcm	28	24	Yamagata	Yamagata	NNP
cord-252443-lclxrwcm	28	25	or	or	CC
cord-252443-lclxrwcm	28	26	Victoria	Victoria	NNP
cord-252443-lclxrwcm	28	27	)	)	-RRB-
cord-252443-lclxrwcm	28	28	(	(	-LRB-
cord-252443-lclxrwcm	28	29	2	2	CD
cord-252443-lclxrwcm	28	30	)	)	-RRB-
cord-252443-lclxrwcm	28	31	.	.	.
cord-252443-lclxrwcm	29	1	Many	many	JJ
cord-252443-lclxrwcm	29	2	countries	country	NNS
cord-252443-lclxrwcm	29	3	have	have	VBP
cord-252443-lclxrwcm	29	4	implemented	implement	VBN
cord-252443-lclxrwcm	29	5	influenza	influenza	JJ
cord-252443-lclxrwcm	29	6	healthcare	healthcare	NN
cord-252443-lclxrwcm	29	7	strategies	strategy	NNS
cord-252443-lclxrwcm	29	8	in	in	IN
cord-252443-lclxrwcm	29	9	which	which	WDT
cord-252443-lclxrwcm	29	10	the	the	DT
cord-252443-lclxrwcm	29	11	vaccination	vaccination	NN
cord-252443-lclxrwcm	29	12	is	be	VBZ
cord-252443-lclxrwcm	29	13	administered	administer	VBN
cord-252443-lclxrwcm	29	14	to	to	IN
cord-252443-lclxrwcm	29	15	discrete	discrete	JJ
cord-252443-lclxrwcm	29	16	population	population	NN
cord-252443-lclxrwcm	29	17	cohorts	cohort	NNS
cord-252443-lclxrwcm	29	18	at	at	IN
cord-252443-lclxrwcm	29	19	risk	risk	NN
cord-252443-lclxrwcm	29	20	of	of	IN
cord-252443-lclxrwcm	29	21	complications	complication	NNS
cord-252443-lclxrwcm	29	22	,	,	,
cord-252443-lclxrwcm	29	23	the	the	DT
cord-252443-lclxrwcm	29	24	very	very	RB
cord-252443-lclxrwcm	29	25	young	young	JJ
cord-252443-lclxrwcm	29	26	and	and	CC
cord-252443-lclxrwcm	29	27	the	the	DT
cord-252443-lclxrwcm	29	28	elderly	elderly	JJ
cord-252443-lclxrwcm	29	29	.	.	.
cord-252443-lclxrwcm	30	1	The	the	DT
cord-252443-lclxrwcm	30	2	global	global	JJ
cord-252443-lclxrwcm	30	3	burden	burden	NN
cord-252443-lclxrwcm	30	4	of	of	IN
cord-252443-lclxrwcm	30	5	influenza	influenza	NN
cord-252443-lclxrwcm	30	6	disease	disease	NN
cord-252443-lclxrwcm	30	7	mainly	mainly	RB
cord-252443-lclxrwcm	30	8	occurs	occur	VBZ
cord-252443-lclxrwcm	30	9	in	in	IN
cord-252443-lclxrwcm	30	10	infants	infant	NNS
cord-252443-lclxrwcm	30	11	aged	age	VBN
cord-252443-lclxrwcm	30	12	5	5	CD
cord-252443-lclxrwcm	30	13	years	year	NNS
cord-252443-lclxrwcm	30	14	or	or	CC
cord-252443-lclxrwcm	30	15	under	under	IN
cord-252443-lclxrwcm	30	16	;	;	,
cord-252443-lclxrwcm	30	17	accounting	account	VBG
cord-252443-lclxrwcm	30	18	for	for	IN
cord-252443-lclxrwcm	30	19	90	90	CD
cord-252443-lclxrwcm	30	20	million	million	CD
cord-252443-lclxrwcm	30	21	infections	infection	NNS
cord-252443-lclxrwcm	30	22	annually	annually	RB
cord-252443-lclxrwcm	30	23	(	(	-LRB-
cord-252443-lclxrwcm	30	24	13	13	CD
cord-252443-lclxrwcm	30	25	,	,	,
cord-252443-lclxrwcm	30	26	14	14	CD
cord-252443-lclxrwcm	30	27	)	)	-RRB-
cord-252443-lclxrwcm	30	28	.	.	.
cord-252443-lclxrwcm	31	1	Children	child	NNS
cord-252443-lclxrwcm	31	2	shed	shed	VBP
cord-252443-lclxrwcm	31	3	virus	virus	NN
cord-252443-lclxrwcm	31	4	at	at	IN
cord-252443-lclxrwcm	31	5	a	a	DT
cord-252443-lclxrwcm	31	6	high	high	JJ
cord-252443-lclxrwcm	31	7	rate	rate	NN
cord-252443-lclxrwcm	31	8	and	and	CC
cord-252443-lclxrwcm	31	9	routinely	routinely	RB
cord-252443-lclxrwcm	31	10	congregate	congregate	VBP
cord-252443-lclxrwcm	31	11	in	in	IN
cord-252443-lclxrwcm	31	12	high	high	JJ
cord-252443-lclxrwcm	31	13	numbers	number	NNS
cord-252443-lclxrwcm	31	14	(	(	-LRB-
cord-252443-lclxrwcm	31	15	for	for	IN
cord-252443-lclxrwcm	31	16	example	example	NN
cord-252443-lclxrwcm	31	17	,	,	,
cord-252443-lclxrwcm	31	18	schools	school	NNS
cord-252443-lclxrwcm	31	19	,	,	,
cord-252443-lclxrwcm	31	20	nurseries	nursery	NNS
cord-252443-lclxrwcm	31	21	)	)	-RRB-
cord-252443-lclxrwcm	31	22	,	,	,
cord-252443-lclxrwcm	31	23	thus	thus	RB
cord-252443-lclxrwcm	31	24	facilitating	facilitate	VBG
cord-252443-lclxrwcm	31	25	easy	easy	JJ
cord-252443-lclxrwcm	31	26	dissemination	dissemination	NN
cord-252443-lclxrwcm	31	27	of	of	IN
cord-252443-lclxrwcm	31	28	the	the	DT
cord-252443-lclxrwcm	31	29	virus	virus	NN
cord-252443-lclxrwcm	31	30	to	to	IN
cord-252443-lclxrwcm	31	31	family	family	NN
cord-252443-lclxrwcm	31	32	members	member	NNS
cord-252443-lclxrwcm	31	33	and	and	CC
cord-252443-lclxrwcm	31	34	in	in	IN
cord-252443-lclxrwcm	31	35	turn	turn	VB
cord-252443-lclxrwcm	31	36	the	the	DT
cord-252443-lclxrwcm	31	37	wider	wide	JJR
cord-252443-lclxrwcm	31	38	public	public	NN
cord-252443-lclxrwcm	31	39	.	.	.
cord-252443-lclxrwcm	32	1	The	the	DT
cord-252443-lclxrwcm	32	2	question	question	NN
cord-252443-lclxrwcm	32	3	of	of	IN
cord-252443-lclxrwcm	32	4	whether	whether	IN
cord-252443-lclxrwcm	32	5	to	to	TO
cord-252443-lclxrwcm	32	6	mass	mass	NN
cord-252443-lclxrwcm	32	7	vaccinate	vaccinate	VB
cord-252443-lclxrwcm	32	8	young	young	JJ
cord-252443-lclxrwcm	32	9	children	child	NNS
cord-252443-lclxrwcm	32	10	against	against	IN
cord-252443-lclxrwcm	32	11	influenza	influenza	NN
cord-252443-lclxrwcm	32	12	is	be	VBZ
cord-252443-lclxrwcm	32	13	a	a	DT
cord-252443-lclxrwcm	32	14	point	point	NN
cord-252443-lclxrwcm	32	15	of	of	IN
cord-252443-lclxrwcm	32	16	considerable	considerable	JJ
cord-252443-lclxrwcm	32	17	debate	debate	NN
cord-252443-lclxrwcm	32	18	among	among	IN
cord-252443-lclxrwcm	32	19	both	both	CC
cord-252443-lclxrwcm	32	20	the	the	DT
cord-252443-lclxrwcm	32	21	clinical	clinical	JJ
cord-252443-lclxrwcm	32	22	immunology	immunology	NN
cord-252443-lclxrwcm	32	23	and	and	CC
cord-252443-lclxrwcm	32	24	public	public	JJ
cord-252443-lclxrwcm	32	25	health	health	NN
cord-252443-lclxrwcm	32	26	communities	community	NNS
cord-252443-lclxrwcm	32	27	(	(	-LRB-
cord-252443-lclxrwcm	32	28	15	15	CD
cord-252443-lclxrwcm	32	29	)	)	-RRB-
cord-252443-lclxrwcm	32	30	,	,	,
cord-252443-lclxrwcm	32	31	and	and	CC
cord-252443-lclxrwcm	32	32	at	at	IN
cord-252443-lclxrwcm	32	33	present	present	NN
cord-252443-lclxrwcm	32	34	there	there	EX
cord-252443-lclxrwcm	32	35	is	be	VBZ
cord-252443-lclxrwcm	32	36	no	no	DT
cord-252443-lclxrwcm	32	37	clear	clear	JJ
cord-252443-lclxrwcm	32	38	consensus	consensus	NN
cord-252443-lclxrwcm	32	39	.	.	.
cord-252443-lclxrwcm	33	1	Supporters	supporter	NNS
cord-252443-lclxrwcm	33	2	of	of	IN
cord-252443-lclxrwcm	33	3	vaccinating	vaccinate	VBG
cord-252443-lclxrwcm	33	4	children	child	NNS
cord-252443-lclxrwcm	33	5	against	against	IN
cord-252443-lclxrwcm	33	6	influenza	influenza	NN
cord-252443-lclxrwcm	33	7	argue	argue	VBP
cord-252443-lclxrwcm	33	8	that	that	IN
cord-252443-lclxrwcm	33	9	conferring	confer	VBG
cord-252443-lclxrwcm	33	10	protection	protection	NN
cord-252443-lclxrwcm	33	11	to	to	IN
cord-252443-lclxrwcm	33	12	this	this	DT
cord-252443-lclxrwcm	33	13	segment	segment	NN
cord-252443-lclxrwcm	33	14	of	of	IN
cord-252443-lclxrwcm	33	15	society	society	NN
cord-252443-lclxrwcm	33	16	will	will	MD
cord-252443-lclxrwcm	33	17	not	not	RB
cord-252443-lclxrwcm	33	18	only	only	RB
cord-252443-lclxrwcm	33	19	benefit	benefit	VB
cord-252443-lclxrwcm	33	20	children	child	NNS
cord-252443-lclxrwcm	33	21	,	,	,
cord-252443-lclxrwcm	33	22	but	but	CC
cord-252443-lclxrwcm	33	23	will	will	MD
cord-252443-lclxrwcm	33	24	also	also	RB
cord-252443-lclxrwcm	33	25	benefit	benefit	VB
cord-252443-lclxrwcm	33	26	the	the	DT
cord-252443-lclxrwcm	33	27	wider	wide	JJR
cord-252443-lclxrwcm	33	28	adult	adult	NN
cord-252443-lclxrwcm	33	29	population	population	NN
cord-252443-lclxrwcm	33	30	(	(	-LRB-
cord-252443-lclxrwcm	33	31	1	1	CD
cord-252443-lclxrwcm	33	32	,	,	,
cord-252443-lclxrwcm	33	33	15	15	CD
cord-252443-lclxrwcm	33	34	,	,	,
cord-252443-lclxrwcm	33	35	16	16	CD
cord-252443-lclxrwcm	33	36	)	)	-RRB-
cord-252443-lclxrwcm	33	37	.	.	.
cord-252443-lclxrwcm	34	1	Opposition	opposition	NN
cord-252443-lclxrwcm	34	2	to	to	IN
cord-252443-lclxrwcm	34	3	this	this	DT
cord-252443-lclxrwcm	34	4	healthcare	healthcare	NN
cord-252443-lclxrwcm	34	5	strategy	strategy	NN
cord-252443-lclxrwcm	34	6	hinges	hinge	NNS
cord-252443-lclxrwcm	34	7	on	on	IN
cord-252443-lclxrwcm	34	8	the	the	DT
cord-252443-lclxrwcm	34	9	idea	idea	NN
cord-252443-lclxrwcm	34	10	that	that	IN
cord-252443-lclxrwcm	34	11	individuals	individual	NNS
cord-252443-lclxrwcm	34	12	,	,	,
cord-252443-lclxrwcm	34	13	including	include	VBG
cord-252443-lclxrwcm	34	14	children	child	NNS
cord-252443-lclxrwcm	34	15	,	,	,
cord-252443-lclxrwcm	34	16	may	may	MD
cord-252443-lclxrwcm	34	17	accrue	accrue	VB
cord-252443-lclxrwcm	34	18	better	well	JJR
cord-252443-lclxrwcm	34	19	heterosubtypic	heterosubtypic	JJ
cord-252443-lclxrwcm	34	20	immunity	immunity	NN
cord-252443-lclxrwcm	34	21	through	through	IN
cord-252443-lclxrwcm	34	22	natural	natural	JJ
cord-252443-lclxrwcm	34	23	exposure	exposure	NN
cord-252443-lclxrwcm	34	24	to	to	IN
cord-252443-lclxrwcm	34	25	influenza	influenza	NN
cord-252443-lclxrwcm	34	26	virus	virus	NN
cord-252443-lclxrwcm	34	27	as	as	IN
cord-252443-lclxrwcm	34	28	opposed	oppose	VBN
cord-252443-lclxrwcm	34	29	to	to	IN
cord-252443-lclxrwcm	34	30	vaccination	vaccination	NN
cord-252443-lclxrwcm	34	31	(	(	-LRB-
cord-252443-lclxrwcm	34	32	17	17	CD
cord-252443-lclxrwcm	34	33	)	)	-RRB-
cord-252443-lclxrwcm	34	34	(	(	-LRB-
cord-252443-lclxrwcm	34	35	18	18	CD
cord-252443-lclxrwcm	34	36	)	)	-RRB-
cord-252443-lclxrwcm	34	37	(	(	-LRB-
cord-252443-lclxrwcm	34	38	19	19	CD
cord-252443-lclxrwcm	34	39	)	)	-RRB-
cord-252443-lclxrwcm	34	40	(	(	-LRB-
cord-252443-lclxrwcm	34	41	20	20	CD
cord-252443-lclxrwcm	34	42	)	)	-RRB-
cord-252443-lclxrwcm	34	43	(	(	-LRB-
cord-252443-lclxrwcm	34	44	21	21	CD
cord-252443-lclxrwcm	34	45	)	)	-RRB-
cord-252443-lclxrwcm	34	46	(	(	-LRB-
cord-252443-lclxrwcm	34	47	22	22	CD
cord-252443-lclxrwcm	34	48	)	)	-RRB-
cord-252443-lclxrwcm	34	49	(	(	-LRB-
cord-252443-lclxrwcm	34	50	23	23	CD
cord-252443-lclxrwcm	34	51	)	)	-RRB-
cord-252443-lclxrwcm	34	52	.	.	.
cord-252443-lclxrwcm	35	1	Heterosubtypic	Heterosubtypic	NNP
cord-252443-lclxrwcm	35	2	,	,	,
cord-252443-lclxrwcm	35	3	or	or	CC
cord-252443-lclxrwcm	35	4	cross	cross	NN
cord-252443-lclxrwcm	35	5	-	-	NN
cord-252443-lclxrwcm	35	6	clade	clade	JJ
cord-252443-lclxrwcm	35	7	,	,	,
cord-252443-lclxrwcm	35	8	memory	memory	NN
cord-252443-lclxrwcm	35	9	can	can	MD
cord-252443-lclxrwcm	35	10	be	be	VB
cord-252443-lclxrwcm	35	11	broadly	broadly	RB
cord-252443-lclxrwcm	35	12	classified	classify	VBN
cord-252443-lclxrwcm	35	13	as	as	IN
cord-252443-lclxrwcm	35	14	protection	protection	NN
cord-252443-lclxrwcm	35	15	induced	induce	VBN
cord-252443-lclxrwcm	35	16	to	to	IN
cord-252443-lclxrwcm	35	17	an	an	DT
cord-252443-lclxrwcm	35	18	influenza	influenza	NN
cord-252443-lclxrwcm	35	19	subtype	subtype	NN
cord-252443-lclxrwcm	35	20	or	or	CC
cord-252443-lclxrwcm	35	21	strain	strain	NN
cord-252443-lclxrwcm	35	22	that	that	WDT
cord-252443-lclxrwcm	35	23	confers	confer	VBZ
cord-252443-lclxrwcm	35	24	protection	protection	NN
cord-252443-lclxrwcm	35	25	against	against	IN
cord-252443-lclxrwcm	35	26	other	other	JJ
cord-252443-lclxrwcm	35	27	strains	strain	NNS
cord-252443-lclxrwcm	35	28	and	and	CC
cord-252443-lclxrwcm	35	29	can	can	MD
cord-252443-lclxrwcm	35	30	be	be	VB
cord-252443-lclxrwcm	35	31	mediated	mediate	VBN
cord-252443-lclxrwcm	35	32	by	by	IN
cord-252443-lclxrwcm	35	33	both	both	DT
cord-252443-lclxrwcm	35	34	humoral	humoral	JJ
cord-252443-lclxrwcm	35	35	and	and	CC
cord-252443-lclxrwcm	35	36	cellular	cellular	JJ
cord-252443-lclxrwcm	35	37	immunity	immunity	NN
cord-252443-lclxrwcm	35	38	(	(	-LRB-
cord-252443-lclxrwcm	35	39	24	24	CD
cord-252443-lclxrwcm	35	40	)	)	-RRB-
cord-252443-lclxrwcm	35	41	(	(	-LRB-
cord-252443-lclxrwcm	35	42	25	25	CD
cord-252443-lclxrwcm	35	43	)	)	-RRB-
cord-252443-lclxrwcm	35	44	(	(	-LRB-
cord-252443-lclxrwcm	35	45	26	26	CD
cord-252443-lclxrwcm	35	46	)	)	-RRB-
cord-252443-lclxrwcm	35	47	(	(	-LRB-
cord-252443-lclxrwcm	35	48	27	27	CD
cord-252443-lclxrwcm	35	49	)	)	-RRB-
cord-252443-lclxrwcm	35	50	.	.	.
cord-252443-lclxrwcm	36	1	Approximately	approximately	RB
cord-252443-lclxrwcm	36	2	90	90	CD
cord-252443-lclxrwcm	36	3	%	%	NN
cord-252443-lclxrwcm	36	4	of	of	IN
cord-252443-lclxrwcm	36	5	influenza	influenza	NN
cord-252443-lclxrwcm	36	6	-	-	HYPH
cord-252443-lclxrwcm	36	7	related	relate	VBN
cord-252443-lclxrwcm	36	8	deaths	death	NNS
cord-252443-lclxrwcm	36	9	,	,	,
cord-252443-lclxrwcm	36	10	outside	outside	IN
cord-252443-lclxrwcm	36	11	of	of	IN
cord-252443-lclxrwcm	36	12	pandemic	pandemic	NN
cord-252443-lclxrwcm	36	13	settings	setting	NNS
cord-252443-lclxrwcm	36	14	,	,	,
cord-252443-lclxrwcm	36	15	occur	occur	VBP
cord-252443-lclxrwcm	36	16	among	among	IN
cord-252443-lclxrwcm	36	17	people	people	NNS
cord-252443-lclxrwcm	36	18	aged	age	VBN
cord-252443-lclxrwcm	36	19	65	65	CD
cord-252443-lclxrwcm	36	20	years	year	NNS
cord-252443-lclxrwcm	36	21	or	or	CC
cord-252443-lclxrwcm	36	22	older	old	JJR
cord-252443-lclxrwcm	36	23	and	and	CC
cord-252443-lclxrwcm	36	24	this	this	DT
cord-252443-lclxrwcm	36	25	heightened	heightened	JJ
cord-252443-lclxrwcm	36	26	susceptibility	susceptibility	NN
cord-252443-lclxrwcm	36	27	is	be	VBZ
cord-252443-lclxrwcm	36	28	increased	increase	VBN
cord-252443-lclxrwcm	36	29	as	as	IN
cord-252443-lclxrwcm	36	30	individuals	individual	NNS
cord-252443-lclxrwcm	36	31	age	age	NN
cord-252443-lclxrwcm	36	32	;	;	:
cord-252443-lclxrwcm	36	33	persons	person	NNS
cord-252443-lclxrwcm	36	34	aged	age	VBN
cord-252443-lclxrwcm	36	35	85	85	CD
cord-252443-lclxrwcm	36	36	years	year	NNS
cord-252443-lclxrwcm	36	37	or	or	CC
cord-252443-lclxrwcm	36	38	older	old	JJR
cord-252443-lclxrwcm	36	39	are	be	VBP
cord-252443-lclxrwcm	36	40	16	16	CD
cord-252443-lclxrwcm	36	41	times	time	NNS
cord-252443-lclxrwcm	36	42	more	more	RBR
cord-252443-lclxrwcm	36	43	likely	likely	JJ
cord-252443-lclxrwcm	36	44	to	to	TO
cord-252443-lclxrwcm	36	45	die	die	VB
cord-252443-lclxrwcm	36	46	of	of	IN
cord-252443-lclxrwcm	36	47	an	an	DT
cord-252443-lclxrwcm	36	48	influenza	influenza	NN
cord-252443-lclxrwcm	36	49	-	-	HYPH
cord-252443-lclxrwcm	36	50	related	relate	VBN
cord-252443-lclxrwcm	36	51	death	death	NN
cord-252443-lclxrwcm	36	52	compared	compare	VBN
cord-252443-lclxrwcm	36	53	with	with	IN
cord-252443-lclxrwcm	36	54	those	those	DT
cord-252443-lclxrwcm	36	55	aged	age	VBN
cord-252443-lclxrwcm	36	56	65	65	CD
cord-252443-lclxrwcm	36	57	to	to	TO
cord-252443-lclxrwcm	36	58	69	69	CD
cord-252443-lclxrwcm	36	59	years	year	NNS
cord-252443-lclxrwcm	36	60	(	(	-LRB-
cord-252443-lclxrwcm	36	61	13	13	CD
cord-252443-lclxrwcm	36	62	,	,	,
cord-252443-lclxrwcm	36	63	28	28	CD
cord-252443-lclxrwcm	36	64	)	)	-RRB-
cord-252443-lclxrwcm	36	65	.	.	.
cord-252443-lclxrwcm	37	1	The	the	DT
cord-252443-lclxrwcm	37	2	progressive	progressive	JJ
cord-252443-lclxrwcm	37	3	decline	decline	NN
cord-252443-lclxrwcm	37	4	of	of	IN
cord-252443-lclxrwcm	37	5	the	the	DT
cord-252443-lclxrwcm	37	6	immune	immune	JJ
cord-252443-lclxrwcm	37	7	system	system	NN
cord-252443-lclxrwcm	37	8	is	be	VBZ
cord-252443-lclxrwcm	37	9	thought	think	VBN
cord-252443-lclxrwcm	37	10	to	to	TO
cord-252443-lclxrwcm	37	11	be	be	VB
cord-252443-lclxrwcm	37	12	the	the	DT
cord-252443-lclxrwcm	37	13	principle	principle	JJ
cord-252443-lclxrwcm	37	14	cause	cause	NN
cord-252443-lclxrwcm	37	15	of	of	IN
cord-252443-lclxrwcm	37	16	increased	increase	VBN
cord-252443-lclxrwcm	37	17	susceptibility	susceptibility	NN
cord-252443-lclxrwcm	37	18	to	to	IN
cord-252443-lclxrwcm	37	19	infection	infection	NN
cord-252443-lclxrwcm	37	20	in	in	IN
cord-252443-lclxrwcm	37	21	the	the	DT
cord-252443-lclxrwcm	37	22	older	old	JJR
cord-252443-lclxrwcm	37	23	adult	adult	NN
cord-252443-lclxrwcm	37	24	.	.	.
cord-252443-lclxrwcm	38	1	The	the	DT
cord-252443-lclxrwcm	38	2	age	age	NN
cord-252443-lclxrwcm	38	3	-	-	HYPH
cord-252443-lclxrwcm	38	4	related	relate	VBN
cord-252443-lclxrwcm	38	5	decline	decline	NN
cord-252443-lclxrwcm	38	6	in	in	IN
cord-252443-lclxrwcm	38	7	immune	immune	JJ
cord-252443-lclxrwcm	38	8	responses	response	NNS
cord-252443-lclxrwcm	38	9	(	(	-LRB-
cord-252443-lclxrwcm	38	10	immunosenescence	immunosenescence	NNP
cord-252443-lclxrwcm	38	11	)	)	-RRB-
cord-252443-lclxrwcm	38	12	affects	affect	VBZ
cord-252443-lclxrwcm	38	13	both	both	CC
cord-252443-lclxrwcm	38	14	the	the	DT
cord-252443-lclxrwcm	38	15	innate	innate	JJ
cord-252443-lclxrwcm	38	16	and	and	CC
cord-252443-lclxrwcm	38	17	adaptive	adaptive	JJ
cord-252443-lclxrwcm	38	18	immune	immune	JJ
cord-252443-lclxrwcm	38	19	response	response	NN
cord-252443-lclxrwcm	38	20	(	(	-LRB-
cord-252443-lclxrwcm	38	21	29	29	CD
cord-252443-lclxrwcm	38	22	)	)	-RRB-
cord-252443-lclxrwcm	38	23	.	.	.
cord-252443-lclxrwcm	39	1	Although	although	IN
cord-252443-lclxrwcm	39	2	influenza	influenza	NN
cord-252443-lclxrwcm	39	3	vaccines	vaccine	NNS
cord-252443-lclxrwcm	39	4	have	have	VBP
cord-252443-lclxrwcm	39	5	undoubtedly	undoubtedly	RB
cord-252443-lclxrwcm	39	6	saved	save	VBN
cord-252443-lclxrwcm	39	7	numerous	numerous	JJ
cord-252443-lclxrwcm	39	8	lives	life	NNS
cord-252443-lclxrwcm	39	9	during	during	IN
cord-252443-lclxrwcm	39	10	both	both	DT
cord-252443-lclxrwcm	39	11	pandemic	pandemic	NN
cord-252443-lclxrwcm	39	12	and	and	CC
cord-252443-lclxrwcm	39	13	epidemic	epidemic	NN
cord-252443-lclxrwcm	39	14	outbreaks	outbreak	NNS
cord-252443-lclxrwcm	39	15	,	,	,
cord-252443-lclxrwcm	39	16	there	there	EX
cord-252443-lclxrwcm	39	17	remains	remain	VBZ
cord-252443-lclxrwcm	39	18	considerable	considerable	JJ
cord-252443-lclxrwcm	39	19	variation	variation	NN
cord-252443-lclxrwcm	39	20	in	in	IN
cord-252443-lclxrwcm	39	21	how	how	WRB
cord-252443-lclxrwcm	39	22	influenza	influenza	NN
cord-252443-lclxrwcm	39	23	vaccines	vaccine	NNS
cord-252443-lclxrwcm	39	24	are	be	VBP
cord-252443-lclxrwcm	39	25	used	use	VBN
cord-252443-lclxrwcm	39	26	and	and	CC
cord-252443-lclxrwcm	39	27	the	the	DT
cord-252443-lclxrwcm	39	28	efficacy	efficacy	NN
cord-252443-lclxrwcm	39	29	achieved	achieve	VBN
cord-252443-lclxrwcm	39	30	in	in	IN
cord-252443-lclxrwcm	39	31	targeted	target	VBN
cord-252443-lclxrwcm	39	32	population	population	NN
cord-252443-lclxrwcm	39	33	cohorts	cohort	NNS
cord-252443-lclxrwcm	39	34	.	.	.
cord-252443-lclxrwcm	40	1	As	as	IN
cord-252443-lclxrwcm	40	2	such	such	JJ
cord-252443-lclxrwcm	40	3	,	,	,
cord-252443-lclxrwcm	40	4	influenza	influenza	NN
cord-252443-lclxrwcm	40	5	and	and	CC
cord-252443-lclxrwcm	40	6	its	-PRON-	PRP$
cord-252443-lclxrwcm	40	7	associated	associate	VBN
cord-252443-lclxrwcm	40	8	complications	complication	NNS
cord-252443-lclxrwcm	40	9	still	still	RB
cord-252443-lclxrwcm	40	10	represent	represent	VBP
cord-252443-lclxrwcm	40	11	a	a	DT
cord-252443-lclxrwcm	40	12	considerable	considerable	JJ
cord-252443-lclxrwcm	40	13	global	global	JJ
cord-252443-lclxrwcm	40	14	healthcare	healthcare	NN
cord-252443-lclxrwcm	40	15	burden	burden	NN
cord-252443-lclxrwcm	40	16	.	.	.
cord-252443-lclxrwcm	41	1	For	for	IN
cord-252443-lclxrwcm	41	2	instance	instance	NN
cord-252443-lclxrwcm	41	3	,	,	,
cord-252443-lclxrwcm	41	4	in	in	IN
cord-252443-lclxrwcm	41	5	healthy	healthy	JJ
cord-252443-lclxrwcm	41	6	adults	adult	NNS
cord-252443-lclxrwcm	41	7	,	,	,
cord-252443-lclxrwcm	41	8	the	the	DT
cord-252443-lclxrwcm	41	9	efficacy	efficacy	NN
cord-252443-lclxrwcm	41	10	of	of	IN
cord-252443-lclxrwcm	41	11	inactivated	inactivate	VBN
cord-252443-lclxrwcm	41	12	vaccines	vaccine	NNS
cord-252443-lclxrwcm	41	13	is	be	VBZ
cord-252443-lclxrwcm	41	14	estimated	estimate	VBN
cord-252443-lclxrwcm	41	15	at	at	IN
cord-252443-lclxrwcm	41	16	50	50	CD
cord-252443-lclxrwcm	41	17	-	-	SYM
cord-252443-lclxrwcm	41	18	75	75	CD
cord-252443-lclxrwcm	41	19	%	%	NN
cord-252443-lclxrwcm	41	20	(	(	-LRB-
cord-252443-lclxrwcm	41	21	30	30	CD
cord-252443-lclxrwcm	41	22	,	,	,
cord-252443-lclxrwcm	41	23	31	31	CD
cord-252443-lclxrwcm	41	24	)	)	-RRB-
cord-252443-lclxrwcm	41	25	,	,	,
cord-252443-lclxrwcm	41	26	whereas	whereas	IN
cord-252443-lclxrwcm	41	27	in	in	IN
cord-252443-lclxrwcm	41	28	children	child	NNS
cord-252443-lclxrwcm	41	29	under	under	IN
cord-252443-lclxrwcm	41	30	the	the	DT
cord-252443-lclxrwcm	41	31	age	age	NN
cord-252443-lclxrwcm	41	32	of	of	IN
cord-252443-lclxrwcm	41	33	2	2	CD
cord-252443-lclxrwcm	41	34	years	year	NNS
cord-252443-lclxrwcm	41	35	,	,	,
cord-252443-lclxrwcm	41	36	efficacy	efficacy	NN
cord-252443-lclxrwcm	41	37	associated	associate	VBN
cord-252443-lclxrwcm	41	38	with	with	IN
cord-252443-lclxrwcm	41	39	trivalent	trivalent	JJ
cord-252443-lclxrwcm	41	40	influenza	influenza	NN
cord-252443-lclxrwcm	41	41	vaccine	vaccine	NN
cord-252443-lclxrwcm	41	42	(	(	-LRB-
cord-252443-lclxrwcm	41	43	TIV	TIV	NNP
cord-252443-lclxrwcm	41	44	)	)	-RRB-
cord-252443-lclxrwcm	41	45	vaccination	vaccination	NN
cord-252443-lclxrwcm	41	46	is	be	VBZ
cord-252443-lclxrwcm	41	47	comparable	comparable	JJ
cord-252443-lclxrwcm	41	48	to	to	IN
cord-252443-lclxrwcm	41	49	placebo	placebo	NN
cord-252443-lclxrwcm	41	50	(	(	-LRB-
cord-252443-lclxrwcm	41	51	32	32	CD
cord-252443-lclxrwcm	41	52	)	)	-RRB-
cord-252443-lclxrwcm	41	53	.	.	.
cord-252443-lclxrwcm	42	1	In	in	IN
cord-252443-lclxrwcm	42	2	the	the	DT
cord-252443-lclxrwcm	42	3	elderly	elderly	JJ
cord-252443-lclxrwcm	42	4	,	,	,
cord-252443-lclxrwcm	42	5	the	the	DT
cord-252443-lclxrwcm	42	6	validity	validity	NN
cord-252443-lclxrwcm	42	7	of	of	IN
cord-252443-lclxrwcm	42	8	using	use	VBG
cord-252443-lclxrwcm	42	9	inactivated	inactivate	VBN
cord-252443-lclxrwcm	42	10	influenza	influenza	NN
cord-252443-lclxrwcm	42	11	vaccines	vaccine	NNS
cord-252443-lclxrwcm	42	12	has	have	VBZ
cord-252443-lclxrwcm	42	13	been	be	VBN
cord-252443-lclxrwcm	42	14	questioned	question	VBN
cord-252443-lclxrwcm	42	15	(	(	-LRB-
cord-252443-lclxrwcm	42	16	33	33	CD
cord-252443-lclxrwcm	42	17	)	)	-RRB-
cord-252443-lclxrwcm	42	18	,	,	,
cord-252443-lclxrwcm	42	19	with	with	IN
cord-252443-lclxrwcm	42	20	a	a	DT
cord-252443-lclxrwcm	42	21	recent	recent	JJ
cord-252443-lclxrwcm	42	22	systematic	systematic	JJ
cord-252443-lclxrwcm	42	23	review	review	NN
cord-252443-lclxrwcm	42	24	asserting	assert	VBG
cord-252443-lclxrwcm	42	25	that	that	IN
cord-252443-lclxrwcm	42	26	there	there	EX
cord-252443-lclxrwcm	42	27	is	be	VBZ
cord-252443-lclxrwcm	42	28	no	no	DT
cord-252443-lclxrwcm	42	29	conclusive	conclusive	JJ
cord-252443-lclxrwcm	42	30	evidence	evidence	NN
cord-252443-lclxrwcm	42	31	regarding	regard	VBG
cord-252443-lclxrwcm	42	32	efficacy	efficacy	NN
cord-252443-lclxrwcm	42	33	or	or	CC
cord-252443-lclxrwcm	42	34	effectiveness	effectiveness	NN
cord-252443-lclxrwcm	42	35	of	of	IN
cord-252443-lclxrwcm	42	36	influenza	influenza	NN
cord-252443-lclxrwcm	42	37	vaccines	vaccine	NNS
cord-252443-lclxrwcm	42	38	for	for	IN
cord-252443-lclxrwcm	42	39	people	people	NNS
cord-252443-lclxrwcm	42	40	aged	age	VBN
cord-252443-lclxrwcm	42	41	65	65	CD
cord-252443-lclxrwcm	42	42	years	year	NNS
cord-252443-lclxrwcm	42	43	or	or	CC
cord-252443-lclxrwcm	42	44	older	old	JJR
cord-252443-lclxrwcm	42	45	(	(	-LRB-
cord-252443-lclxrwcm	42	46	34	34	CD
cord-252443-lclxrwcm	42	47	)	)	-RRB-
cord-252443-lclxrwcm	42	48	.	.	.
cord-252443-lclxrwcm	43	1	Compared	compare	VBN
cord-252443-lclxrwcm	43	2	with	with	IN
cord-252443-lclxrwcm	43	3	inactivated	inactivate	VBN
cord-252443-lclxrwcm	43	4	vaccines	vaccine	NNS
cord-252443-lclxrwcm	43	5	,	,	,
cord-252443-lclxrwcm	43	6	efficacy	efficacy	NN
cord-252443-lclxrwcm	43	7	for	for	IN
cord-252443-lclxrwcm	43	8	live	live	JJ
cord-252443-lclxrwcm	43	9	vaccines	vaccine	NNS
cord-252443-lclxrwcm	43	10	in	in	IN
cord-252443-lclxrwcm	43	11	children	child	NNS
cord-252443-lclxrwcm	43	12	is	be	VBZ
cord-252443-lclxrwcm	43	13	considerably	considerably	RB
cord-252443-lclxrwcm	43	14	higher	high	JJR
cord-252443-lclxrwcm	43	15	(	(	-LRB-
cord-252443-lclxrwcm	43	16	approximately	approximately	RB
cord-252443-lclxrwcm	43	17	82	82	CD
cord-252443-lclxrwcm	43	18	%	%	NN
cord-252443-lclxrwcm	43	19	)	)	-RRB-
cord-252443-lclxrwcm	43	20	;	;	:
cord-252443-lclxrwcm	43	21	however	however	RB
cord-252443-lclxrwcm	43	22	,	,	,
cord-252443-lclxrwcm	43	23	live	live	JJ
cord-252443-lclxrwcm	43	24	vaccines	vaccine	NNS
cord-252443-lclxrwcm	43	25	are	be	VBP
cord-252443-lclxrwcm	43	26	also	also	RB
cord-252443-lclxrwcm	43	27	associated	associate	VBN
cord-252443-lclxrwcm	43	28	with	with	IN
cord-252443-lclxrwcm	43	29	low	low	JJ
cord-252443-lclxrwcm	43	30	effectiveness	effectiveness	NN
cord-252443-lclxrwcm	43	31	(	(	-LRB-
cord-252443-lclxrwcm	43	32	approximately	approximately	RB
cord-252443-lclxrwcm	43	33	33	33	CD
cord-252443-lclxrwcm	43	34	%	%	NN
cord-252443-lclxrwcm	43	35	)	)	-RRB-
cord-252443-lclxrwcm	43	36	(	(	-LRB-
cord-252443-lclxrwcm	43	37	32	32	CD
cord-252443-lclxrwcm	43	38	)	)	-RRB-
cord-252443-lclxrwcm	43	39	.	.	.
cord-252443-lclxrwcm	44	1	Moreover	moreover	RB
cord-252443-lclxrwcm	44	2	,	,	,
cord-252443-lclxrwcm	44	3	LAIV	LAIV	NNP
cord-252443-lclxrwcm	44	4	is	be	VBZ
cord-252443-lclxrwcm	44	5	not	not	RB
cord-252443-lclxrwcm	44	6	licensed	license	VBN
cord-252443-lclxrwcm	44	7	in	in	IN
cord-252443-lclxrwcm	44	8	children	child	NNS
cord-252443-lclxrwcm	44	9	under	under	IN
cord-252443-lclxrwcm	44	10	2	2	CD
cord-252443-lclxrwcm	44	11	years	year	NNS
cord-252443-lclxrwcm	44	12	of	of	IN
cord-252443-lclxrwcm	44	13	age	age	NN
cord-252443-lclxrwcm	44	14	because	because	IN
cord-252443-lclxrwcm	44	15	it	-PRON-	PRP
cord-252443-lclxrwcm	44	16	is	be	VBZ
cord-252443-lclxrwcm	44	17	associated	associate	VBN
cord-252443-lclxrwcm	44	18	with	with	IN
cord-252443-lclxrwcm	44	19	an	an	DT
cord-252443-lclxrwcm	44	20	increased	increase	VBN
cord-252443-lclxrwcm	44	21	risk	risk	NN
cord-252443-lclxrwcm	44	22	of	of	IN
cord-252443-lclxrwcm	44	23	associated	associated	JJ
cord-252443-lclxrwcm	44	24	wheezing	wheezing	NN
cord-252443-lclxrwcm	44	25	(	(	-LRB-
cord-252443-lclxrwcm	44	26	32	32	CD
cord-252443-lclxrwcm	44	27	)	)	-RRB-
cord-252443-lclxrwcm	44	28	,	,	,
cord-252443-lclxrwcm	44	29	and	and	CC
cord-252443-lclxrwcm	44	30	in	in	IN
cord-252443-lclxrwcm	44	31	adults	adult	NNS
cord-252443-lclxrwcm	44	32	over	over	IN
cord-252443-lclxrwcm	44	33	the	the	DT
cord-252443-lclxrwcm	44	34	age	age	NN
cord-252443-lclxrwcm	44	35	of	of	IN
cord-252443-lclxrwcm	44	36	49	49	CD
cord-252443-lclxrwcm	44	37	years	year	NNS
cord-252443-lclxrwcm	44	38	,	,	,
cord-252443-lclxrwcm	44	39	LAIV	LAIV	NNP
cord-252443-lclxrwcm	44	40	is	be	VBZ
cord-252443-lclxrwcm	44	41	not	not	RB
cord-252443-lclxrwcm	44	42	licensed	license	VBN
cord-252443-lclxrwcm	44	43	owing	owing	NN
cord-252443-lclxrwcm	44	44	to	to	IN
cord-252443-lclxrwcm	44	45	a	a	DT
cord-252443-lclxrwcm	44	46	lack	lack	NN
cord-252443-lclxrwcm	44	47	of	of	IN
cord-252443-lclxrwcm	44	48	corroborated	corroborate	VBN
cord-252443-lclxrwcm	44	49	efficacy	efficacy	NN
cord-252443-lclxrwcm	44	50	(	(	-LRB-
cord-252443-lclxrwcm	44	51	35	35	CD
cord-252443-lclxrwcm	44	52	)	)	-RRB-
cord-252443-lclxrwcm	44	53	.	.	.
cord-252443-lclxrwcm	45	1	Thus	thus	RB
cord-252443-lclxrwcm	45	2	,	,	,
cord-252443-lclxrwcm	45	3	there	there	EX
cord-252443-lclxrwcm	45	4	is	be	VBZ
cord-252443-lclxrwcm	45	5	a	a	DT
cord-252443-lclxrwcm	45	6	clear	clear	JJ
cord-252443-lclxrwcm	45	7	need	need	NN
cord-252443-lclxrwcm	45	8	to	to	TO
cord-252443-lclxrwcm	45	9	develop	develop	VB
cord-252443-lclxrwcm	45	10	effective	effective	JJ
cord-252443-lclxrwcm	45	11	and	and	CC
cord-252443-lclxrwcm	45	12	efficacious	efficacious	JJ
cord-252443-lclxrwcm	45	13	influenza	influenza	NN
cord-252443-lclxrwcm	45	14	vaccines	vaccine	NNS
cord-252443-lclxrwcm	45	15	for	for	IN
cord-252443-lclxrwcm	45	16	both	both	DT
cord-252443-lclxrwcm	45	17	infants	infant	NNS
cord-252443-lclxrwcm	45	18	and	and	CC
cord-252443-lclxrwcm	45	19	the	the	DT
cord-252443-lclxrwcm	45	20	elderly	elderly	JJ
cord-252443-lclxrwcm	45	21	.	.	.
cord-252443-lclxrwcm	46	1	Before	before	IN
cord-252443-lclxrwcm	46	2	being	be	VBG
cord-252443-lclxrwcm	46	3	able	able	JJ
cord-252443-lclxrwcm	46	4	to	to	TO
cord-252443-lclxrwcm	46	5	do	do	VB
cord-252443-lclxrwcm	46	6	this	this	DT
cord-252443-lclxrwcm	46	7	,	,	,
cord-252443-lclxrwcm	46	8	however	however	RB
cord-252443-lclxrwcm	46	9	,	,	,
cord-252443-lclxrwcm	46	10	we	-PRON-	PRP
cord-252443-lclxrwcm	46	11	must	must	MD
cord-252443-lclxrwcm	46	12	understand	understand	VB
cord-252443-lclxrwcm	46	13	what	what	WP
cord-252443-lclxrwcm	46	14	factors	factor	NNS
cord-252443-lclxrwcm	46	15	underpin	underpin	VBP
cord-252443-lclxrwcm	46	16	the	the	DT
cord-252443-lclxrwcm	46	17	current	current	JJ
cord-252443-lclxrwcm	46	18	limitations	limitation	NNS
cord-252443-lclxrwcm	46	19	of	of	IN
cord-252443-lclxrwcm	46	20	licensed	license	VBN
cord-252443-lclxrwcm	46	21	influenza	influenza	NN
cord-252443-lclxrwcm	46	22	vaccines	vaccine	NNS
cord-252443-lclxrwcm	46	23	.	.	.
cord-252443-lclxrwcm	47	1	Humoral	Humoral	NNP
cord-252443-lclxrwcm	47	2	immune	immune	JJ
cord-252443-lclxrwcm	47	3	response	response	NN
cord-252443-lclxrwcm	47	4	.	.	.
cord-252443-lclxrwcm	48	1	Currently	currently	RB
cord-252443-lclxrwcm	48	2	licensed	license	VBN
cord-252443-lclxrwcm	48	3	influenza	influenza	NN
cord-252443-lclxrwcm	48	4	vaccines	vaccine	NNS
cord-252443-lclxrwcm	48	5	induce	induce	VBP
cord-252443-lclxrwcm	48	6	a	a	DT
cord-252443-lclxrwcm	48	7	relatively	relatively	RB
cord-252443-lclxrwcm	48	8	narrow	narrow	JJ
cord-252443-lclxrwcm	48	9	adaptive	adaptive	JJ
cord-252443-lclxrwcm	48	10	immune	immune	JJ
cord-252443-lclxrwcm	48	11	response	response	NN
cord-252443-lclxrwcm	48	12	with	with	IN
cord-252443-lclxrwcm	48	13	limited	limited	JJ
cord-252443-lclxrwcm	48	14	cross	cross	JJ
cord-252443-lclxrwcm	48	15	-	-	JJ
cord-252443-lclxrwcm	48	16	clade	clade	JJ
cord-252443-lclxrwcm	48	17	immunity	immunity	NN
cord-252443-lclxrwcm	48	18	.	.	.
cord-252443-lclxrwcm	49	1	Cross	cross	NN
cord-252443-lclxrwcm	49	2	-	-	JJ
cord-252443-lclxrwcm	49	3	clade	clade	JJ
cord-252443-lclxrwcm	49	4	protection	protection	NN
cord-252443-lclxrwcm	49	5	refers	refer	VBZ
cord-252443-lclxrwcm	49	6	to	to	IN
cord-252443-lclxrwcm	49	7	protective	protective	JJ
cord-252443-lclxrwcm	49	8	immunity	immunity	NN
cord-252443-lclxrwcm	49	9	against	against	IN
cord-252443-lclxrwcm	49	10	one	one	CD
cord-252443-lclxrwcm	49	11	influenza	influenza	NN
cord-252443-lclxrwcm	49	12	isolate	isolate	NN
cord-252443-lclxrwcm	49	13	,	,	,
cord-252443-lclxrwcm	49	14	which	which	WDT
cord-252443-lclxrwcm	49	15	subsequently	subsequently	RB
cord-252443-lclxrwcm	49	16	confers	confer	VBZ
cord-252443-lclxrwcm	49	17	protective	protective	JJ
cord-252443-lclxrwcm	49	18	efficacy	efficacy	NN
cord-252443-lclxrwcm	49	19	upon	upon	IN
cord-252443-lclxrwcm	49	20	exposure	exposure	NN
cord-252443-lclxrwcm	49	21	to	to	IN
cord-252443-lclxrwcm	49	22	different	different	JJ
cord-252443-lclxrwcm	49	23	isolates	isolate	NNS
cord-252443-lclxrwcm	49	24	.	.	.
cord-252443-lclxrwcm	50	1	The	the	DT
cord-252443-lclxrwcm	50	2	majority	majority	NN
cord-252443-lclxrwcm	50	3	of	of	IN
cord-252443-lclxrwcm	50	4	humoral	humoral	JJ
cord-252443-lclxrwcm	50	5	responses	response	NNS
cord-252443-lclxrwcm	50	6	following	follow	VBG
cord-252443-lclxrwcm	50	7	influenza	influenza	NN
cord-252443-lclxrwcm	50	8	vaccination	vaccination	NN
cord-252443-lclxrwcm	50	9	are	be	VBP
cord-252443-lclxrwcm	50	10	directed	direct	VBN
cord-252443-lclxrwcm	50	11	toward	toward	IN
cord-252443-lclxrwcm	50	12	HA	HA	NNP
cord-252443-lclxrwcm	50	13	,	,	,
cord-252443-lclxrwcm	50	14	principally	principally	RB
cord-252443-lclxrwcm	50	15	toward	toward	IN
cord-252443-lclxrwcm	50	16	the	the	DT
cord-252443-lclxrwcm	50	17	globular	globular	JJ
cord-252443-lclxrwcm	50	18	head	head	NN
cord-252443-lclxrwcm	50	19	domain	domain	NN
cord-252443-lclxrwcm	50	20	found	find	VBN
cord-252443-lclxrwcm	50	21	in	in	IN
cord-252443-lclxrwcm	50	22	the	the	DT
cord-252443-lclxrwcm	50	23	HA1	HA1	NNP
cord-252443-lclxrwcm	50	24	segment	segment	NN
cord-252443-lclxrwcm	50	25	.	.	.
cord-252443-lclxrwcm	51	1	Due	due	IN
cord-252443-lclxrwcm	51	2	to	to	IN
cord-252443-lclxrwcm	51	3	the	the	DT
cord-252443-lclxrwcm	51	4	constantly	constantly	RB
cord-252443-lclxrwcm	51	5	evolving	evolve	VBG
cord-252443-lclxrwcm	51	6	and	and	CC
cord-252443-lclxrwcm	51	7	mutating	mutate	VBG
cord-252443-lclxrwcm	51	8	propensity	propensity	NN
cord-252443-lclxrwcm	51	9	of	of	IN
cord-252443-lclxrwcm	51	10	HA	HA	NNP
cord-252443-lclxrwcm	51	11	,	,	,
cord-252443-lclxrwcm	51	12	these	these	DT
cord-252443-lclxrwcm	51	13	neutralizing	neutralize	VBG
cord-252443-lclxrwcm	51	14	antibodies	antibody	NNS
cord-252443-lclxrwcm	51	15	offer	offer	VBP
cord-252443-lclxrwcm	51	16	little	little	JJ
cord-252443-lclxrwcm	51	17	or	or	CC
cord-252443-lclxrwcm	51	18	no	no	DT
cord-252443-lclxrwcm	51	19	protection	protection	NN
cord-252443-lclxrwcm	51	20	between	between	IN
cord-252443-lclxrwcm	51	21	subtypes	subtype	NNS
cord-252443-lclxrwcm	51	22	or	or	CC
cord-252443-lclxrwcm	51	23	even	even	RB
cord-252443-lclxrwcm	51	24	between	between	IN
cord-252443-lclxrwcm	51	25	strains	strain	NNS
cord-252443-lclxrwcm	51	26	,	,	,
cord-252443-lclxrwcm	51	27	and	and	CC
cord-252443-lclxrwcm	51	28	in	in	IN
cord-252443-lclxrwcm	51	29	some	some	DT
cord-252443-lclxrwcm	51	30	cases	case	NNS
cord-252443-lclxrwcm	51	31	appear	appear	VBP
cord-252443-lclxrwcm	51	32	to	to	TO
cord-252443-lclxrwcm	51	33	be	be	VB
cord-252443-lclxrwcm	51	34	detrimental	detrimental	JJ
cord-252443-lclxrwcm	51	35	(	(	-LRB-
cord-252443-lclxrwcm	51	36	18	18	CD
cord-252443-lclxrwcm	51	37	)	)	-RRB-
cord-252443-lclxrwcm	51	38	.	.	.
cord-252443-lclxrwcm	52	1	This	this	DT
cord-252443-lclxrwcm	52	2	is	be	VBZ
cord-252443-lclxrwcm	52	3	a	a	DT
cord-252443-lclxrwcm	52	4	considerable	considerable	JJ
cord-252443-lclxrwcm	52	5	disadvantage	disadvantage	NN
cord-252443-lclxrwcm	52	6	considering	consider	VBG
cord-252443-lclxrwcm	52	7	influenza	influenza	NN
cord-252443-lclxrwcm	52	8	A	a	DT
cord-252443-lclxrwcm	52	9	undergoes	undergo	VBZ
cord-252443-lclxrwcm	52	10	both	both	DT
cord-252443-lclxrwcm	52	11	antigenic	antigenic	JJ
cord-252443-lclxrwcm	52	12	drift	drift	NN
cord-252443-lclxrwcm	52	13	and	and	CC
cord-252443-lclxrwcm	52	14	antigenic	antigenic	JJ
cord-252443-lclxrwcm	52	15	shift	shift	NN
cord-252443-lclxrwcm	52	16	(	(	-LRB-
cord-252443-lclxrwcm	52	17	36	36	CD
cord-252443-lclxrwcm	52	18	)	)	-RRB-
cord-252443-lclxrwcm	52	19	.	.	.
cord-252443-lclxrwcm	53	1	Antigenic	antigenic	JJ
cord-252443-lclxrwcm	53	2	drift	drift	NN
cord-252443-lclxrwcm	53	3	refers	refer	VBZ
cord-252443-lclxrwcm	53	4	to	to	IN
cord-252443-lclxrwcm	53	5	small	small	JJ
cord-252443-lclxrwcm	53	6	,	,	,
cord-252443-lclxrwcm	53	7	gradual	gradual	JJ
cord-252443-lclxrwcm	53	8	changes	change	NNS
cord-252443-lclxrwcm	53	9	that	that	WDT
cord-252443-lclxrwcm	53	10	occur	occur	VBP
cord-252443-lclxrwcm	53	11	through	through	IN
cord-252443-lclxrwcm	53	12	point	point	NN
cord-252443-lclxrwcm	53	13	mutations	mutation	NNS
cord-252443-lclxrwcm	53	14	in	in	IN
cord-252443-lclxrwcm	53	15	the	the	DT
cord-252443-lclxrwcm	53	16	HA	HA	NNP
cord-252443-lclxrwcm	53	17	or	or	CC
cord-252443-lclxrwcm	53	18	NA	NA	NNP
cord-252443-lclxrwcm	53	19	coding	code	VBG
cord-252443-lclxrwcm	53	20	genes	gene	NNS
cord-252443-lclxrwcm	53	21	.	.	.
cord-252443-lclxrwcm	54	1	Antigenic	antigenic	JJ
cord-252443-lclxrwcm	54	2	shift	shift	NN
cord-252443-lclxrwcm	54	3	refers	refer	VBZ
cord-252443-lclxrwcm	54	4	to	to	IN
cord-252443-lclxrwcm	54	5	an	an	DT
cord-252443-lclxrwcm	54	6	abrupt	abrupt	JJ
cord-252443-lclxrwcm	54	7	,	,	,
cord-252443-lclxrwcm	54	8	major	major	JJ
cord-252443-lclxrwcm	54	9	alteration	alteration	NN
cord-252443-lclxrwcm	54	10	that	that	WDT
cord-252443-lclxrwcm	54	11	generally	generally	RB
cord-252443-lclxrwcm	54	12	produces	produce	VBZ
cord-252443-lclxrwcm	54	13	a	a	DT
cord-252443-lclxrwcm	54	14	subtype	subtype	NN
cord-252443-lclxrwcm	54	15	change	change	NN
cord-252443-lclxrwcm	54	16	and	and	CC
cord-252443-lclxrwcm	54	17	can	can	MD
cord-252443-lclxrwcm	54	18	occur	occur	VB
cord-252443-lclxrwcm	54	19	through	through	IN
cord-252443-lclxrwcm	54	20	either	either	CC
cord-252443-lclxrwcm	54	21	direct	direct	JJ
cord-252443-lclxrwcm	54	22	animal	animal	NN
cord-252443-lclxrwcm	54	23	-	-	HYPH
cord-252443-lclxrwcm	54	24	to	to	IN
cord-252443-lclxrwcm	54	25	-	-	HYPH
cord-252443-lclxrwcm	54	26	human	human	JJ
cord-252443-lclxrwcm	54	27	transmission	transmission	NN
cord-252443-lclxrwcm	54	28	or	or	CC
cord-252443-lclxrwcm	54	29	through	through	IN
cord-252443-lclxrwcm	54	30	a	a	DT
cord-252443-lclxrwcm	54	31	reassortment	reassortment	NN
cord-252443-lclxrwcm	54	32	of	of	IN
cord-252443-lclxrwcm	54	33	human	human	JJ
cord-252443-lclxrwcm	54	34	and	and	CC
cord-252443-lclxrwcm	54	35	animal	animal	NN
cord-252443-lclxrwcm	54	36	influenza	influenza	NN
cord-252443-lclxrwcm	54	37	A	a	NN
cord-252443-lclxrwcm	54	38	(	(	-LRB-
cord-252443-lclxrwcm	54	39	36	36	CD
cord-252443-lclxrwcm	54	40	)	)	-RRB-
cord-252443-lclxrwcm	54	41	.	.	.
cord-252443-lclxrwcm	55	1	Most	Most	JJS
cord-252443-lclxrwcm	55	2	escape	escape	NN
cord-252443-lclxrwcm	55	3	mutants	mutant	NNS
cord-252443-lclxrwcm	55	4	contain	contain	VBP
cord-252443-lclxrwcm	55	5	mutations	mutation	NNS
cord-252443-lclxrwcm	55	6	in	in	IN
cord-252443-lclxrwcm	55	7	the	the	DT
cord-252443-lclxrwcm	55	8	globular	globular	JJ
cord-252443-lclxrwcm	55	9	head	head	NN
cord-252443-lclxrwcm	55	10	domain	domain	NN
cord-252443-lclxrwcm	55	11	,	,	,
cord-252443-lclxrwcm	55	12	and	and	CC
cord-252443-lclxrwcm	55	13	this	this	DT
cord-252443-lclxrwcm	55	14	region	region	NN
cord-252443-lclxrwcm	55	15	of	of	IN
cord-252443-lclxrwcm	55	16	the	the	DT
cord-252443-lclxrwcm	55	17	protein	protein	NN
cord-252443-lclxrwcm	55	18	contains	contain	VBZ
cord-252443-lclxrwcm	55	19	widespread	widespread	JJ
cord-252443-lclxrwcm	55	20	immunodominant	immunodominant	JJ
cord-252443-lclxrwcm	55	21	decoy	decoy	NN
cord-252443-lclxrwcm	55	22	domains	domain	NNS
cord-252443-lclxrwcm	55	23	,	,	,
cord-252443-lclxrwcm	55	24	which	which	WDT
cord-252443-lclxrwcm	55	25	can	can	MD
cord-252443-lclxrwcm	55	26	readily	readily	RB
cord-252443-lclxrwcm	55	27	mutate	mutate	VB
cord-252443-lclxrwcm	55	28	without	without	IN
cord-252443-lclxrwcm	55	29	significantly	significantly	RB
cord-252443-lclxrwcm	55	30	affecting	affect	VBG
cord-252443-lclxrwcm	55	31	virus	virus	NN
cord-252443-lclxrwcm	55	32	fitness	fitness	NN
cord-252443-lclxrwcm	55	33	(	(	-LRB-
cord-252443-lclxrwcm	55	34	37	37	CD
cord-252443-lclxrwcm	55	35	)	)	-RRB-
cord-252443-lclxrwcm	55	36	.	.	.
cord-252443-lclxrwcm	56	1	Thus	thus	RB
cord-252443-lclxrwcm	56	2	,	,	,
cord-252443-lclxrwcm	56	3	yearly	yearly	JJ
cord-252443-lclxrwcm	56	4	vaccinations	vaccination	NNS
cord-252443-lclxrwcm	56	5	with	with	IN
cord-252443-lclxrwcm	56	6	reformulated	reformulate	VBN
cord-252443-lclxrwcm	56	7	vaccines	vaccine	NNS
cord-252443-lclxrwcm	56	8	are	be	VBP
cord-252443-lclxrwcm	56	9	required	require	VBN
cord-252443-lclxrwcm	56	10	because	because	IN
cord-252443-lclxrwcm	56	11	of	of	IN
cord-252443-lclxrwcm	56	12	the	the	DT
cord-252443-lclxrwcm	56	13	antigenic	antigenic	JJ
cord-252443-lclxrwcm	56	14	differences	difference	NNS
cord-252443-lclxrwcm	56	15	that	that	WDT
cord-252443-lclxrwcm	56	16	occur	occur	VBP
cord-252443-lclxrwcm	56	17	between	between	IN
cord-252443-lclxrwcm	56	18	,	,	,
cord-252443-lclxrwcm	56	19	and	and	CC
cord-252443-lclxrwcm	56	20	even	even	RB
cord-252443-lclxrwcm	56	21	within	within	IN
cord-252443-lclxrwcm	56	22	,	,	,
cord-252443-lclxrwcm	56	23	influenza	influenza	NN
cord-252443-lclxrwcm	56	24	strains	strain	NNS
cord-252443-lclxrwcm	56	25	.	.	.
cord-252443-lclxrwcm	57	1	Natural	natural	JJ
cord-252443-lclxrwcm	57	2	exposure	exposure	NN
cord-252443-lclxrwcm	57	3	to	to	IN
cord-252443-lclxrwcm	57	4	influenza	influenza	NN
cord-252443-lclxrwcm	57	5	is	be	VBZ
cord-252443-lclxrwcm	57	6	thought	think	VBN
cord-252443-lclxrwcm	57	7	to	to	TO
cord-252443-lclxrwcm	57	8	induce	induce	VB
cord-252443-lclxrwcm	57	9	a	a	DT
cord-252443-lclxrwcm	57	10	broad	broad	JJ
cord-252443-lclxrwcm	57	11	immune	immune	JJ
cord-252443-lclxrwcm	57	12	response	response	NN
cord-252443-lclxrwcm	57	13	,	,	,
cord-252443-lclxrwcm	57	14	inducing	induce	VBG
cord-252443-lclxrwcm	57	15	cross	cross	JJ
cord-252443-lclxrwcm	57	16	-	-	JJ
cord-252443-lclxrwcm	57	17	clade	clade	JJ
cord-252443-lclxrwcm	57	18	protection	protection	NN
cord-252443-lclxrwcm	57	19	through	through	IN
cord-252443-lclxrwcm	57	20	T	T	NNP
cord-252443-lclxrwcm	57	21	-	-	HYPH
cord-252443-lclxrwcm	57	22	and	and	CC
cord-252443-lclxrwcm	57	23	B	b	NN
cord-252443-lclxrwcm	57	24	-	-	HYPH
cord-252443-lclxrwcm	57	25	cell	cell	NN
cord-252443-lclxrwcm	57	26	responses	response	NNS
cord-252443-lclxrwcm	57	27	(	(	-LRB-
cord-252443-lclxrwcm	57	28	25	25	CD
cord-252443-lclxrwcm	57	29	,	,	,
cord-252443-lclxrwcm	57	30	38	38	CD
cord-252443-lclxrwcm	57	31	,	,	,
cord-252443-lclxrwcm	57	32	39	39	CD
cord-252443-lclxrwcm	57	33	)	)	-RRB-
cord-252443-lclxrwcm	57	34	.	.	.
cord-252443-lclxrwcm	58	1	Indeed	indeed	RB
cord-252443-lclxrwcm	58	2	,	,	,
cord-252443-lclxrwcm	58	3	antibodies	antibody	NNS
cord-252443-lclxrwcm	58	4	directed	direct	VBN
cord-252443-lclxrwcm	58	5	against	against	IN
cord-252443-lclxrwcm	58	6	the	the	DT
cord-252443-lclxrwcm	58	7	stalk	stalk	NN
cord-252443-lclxrwcm	58	8	region	region	NN
cord-252443-lclxrwcm	58	9	of	of	IN
cord-252443-lclxrwcm	58	10	HA	HA	NNP
cord-252443-lclxrwcm	58	11	have	have	VBP
cord-252443-lclxrwcm	58	12	previously	previously	RB
cord-252443-lclxrwcm	58	13	been	be	VBN
cord-252443-lclxrwcm	58	14	shown	show	VBN
cord-252443-lclxrwcm	58	15	to	to	TO
cord-252443-lclxrwcm	58	16	confer	confer	VB
cord-252443-lclxrwcm	58	17	broadspectrum	broadspectrum	NNP
cord-252443-lclxrwcm	58	18	protection	protection	NN
cord-252443-lclxrwcm	58	19	toward	toward	IN
cord-252443-lclxrwcm	58	20	different	different	JJ
cord-252443-lclxrwcm	58	21	influenza	influenza	NN
cord-252443-lclxrwcm	58	22	isolates	isolate	NNS
cord-252443-lclxrwcm	58	23	(	(	-LRB-
cord-252443-lclxrwcm	58	24	40	40	CD
cord-252443-lclxrwcm	58	25	)	)	-RRB-
cord-252443-lclxrwcm	58	26	.	.	.
cord-252443-lclxrwcm	59	1	Annual	annual	JJ
cord-252443-lclxrwcm	59	2	vaccination	vaccination	NN
cord-252443-lclxrwcm	59	3	with	with	IN
cord-252443-lclxrwcm	59	4	TIV	TIV	NNP
cord-252443-lclxrwcm	59	5	is	be	VBZ
cord-252443-lclxrwcm	59	6	thought	think	VBN
cord-252443-lclxrwcm	59	7	to	to	TO
cord-252443-lclxrwcm	59	8	be	be	VB
cord-252443-lclxrwcm	59	9	a	a	DT
cord-252443-lclxrwcm	59	10	relatively	relatively	RB
cord-252443-lclxrwcm	59	11	poor	poor	JJ
cord-252443-lclxrwcm	59	12	inducer	inducer	NN
cord-252443-lclxrwcm	59	13	of	of	IN
cord-252443-lclxrwcm	59	14	these	these	DT
cord-252443-lclxrwcm	59	15	cross	cross	NN
cord-252443-lclxrwcm	59	16	-	-	JJ
cord-252443-lclxrwcm	59	17	clade	clade	JJ
cord-252443-lclxrwcm	59	18	immune	immune	JJ
cord-252443-lclxrwcm	59	19	responses	response	NNS
cord-252443-lclxrwcm	59	20	(	(	-LRB-
cord-252443-lclxrwcm	59	21	18	18	CD
cord-252443-lclxrwcm	59	22	,	,	,
cord-252443-lclxrwcm	59	23	23	23	CD
cord-252443-lclxrwcm	59	24	)	)	-RRB-
cord-252443-lclxrwcm	59	25	.	.	.
cord-252443-lclxrwcm	60	1	Cellular	cellular	JJ
cord-252443-lclxrwcm	60	2	immune	immune	JJ
cord-252443-lclxrwcm	60	3	response	response	NN
cord-252443-lclxrwcm	60	4	.	.	.
cord-252443-lclxrwcm	61	1	Cellular	cellular	JJ
cord-252443-lclxrwcm	61	2	immune	immune	JJ
cord-252443-lclxrwcm	61	3	responses	response	NNS
cord-252443-lclxrwcm	61	4	are	be	VBP
cord-252443-lclxrwcm	61	5	thought	think	VBN
cord-252443-lclxrwcm	61	6	to	to	TO
cord-252443-lclxrwcm	61	7	play	play	VB
cord-252443-lclxrwcm	61	8	an	an	DT
cord-252443-lclxrwcm	61	9	important	important	JJ
cord-252443-lclxrwcm	61	10	protective	protective	JJ
cord-252443-lclxrwcm	61	11	role	role	NN
cord-252443-lclxrwcm	61	12	during	during	IN
cord-252443-lclxrwcm	61	13	influenza	influenza	NN
cord-252443-lclxrwcm	61	14	infection	infection	NN
cord-252443-lclxrwcm	61	15	,	,	,
cord-252443-lclxrwcm	61	16	and	and	CC
cord-252443-lclxrwcm	61	17	human	human	JJ
cord-252443-lclxrwcm	61	18	challenge	challenge	NN
cord-252443-lclxrwcm	61	19	studies	study	NNS
cord-252443-lclxrwcm	61	20	have	have	VBP
cord-252443-lclxrwcm	61	21	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	61	22	a	a	DT
cord-252443-lclxrwcm	61	23	negative	negative	JJ
cord-252443-lclxrwcm	61	24	correlation	correlation	NN
cord-252443-lclxrwcm	61	25	between	between	IN
cord-252443-lclxrwcm	61	26	T	t	NN
cord-252443-lclxrwcm	61	27	-	-	HYPH
cord-252443-lclxrwcm	61	28	cell	cell	NN
cord-252443-lclxrwcm	61	29	responses	response	NNS
cord-252443-lclxrwcm	61	30	to	to	IN
cord-252443-lclxrwcm	61	31	viral	viral	JJ
cord-252443-lclxrwcm	61	32	antigens	antigen	NNS
cord-252443-lclxrwcm	61	33	and	and	CC
cord-252443-lclxrwcm	61	34	influenza	influenza	NN
cord-252443-lclxrwcm	61	35	disease	disease	NN
cord-252443-lclxrwcm	61	36	(	(	-LRB-
cord-252443-lclxrwcm	61	37	38	38	CD
cord-252443-lclxrwcm	61	38	)	)	-RRB-
cord-252443-lclxrwcm	61	39	.	.	.
cord-252443-lclxrwcm	62	1	T	t	NN
cord-252443-lclxrwcm	62	2	-	-	HYPH
cord-252443-lclxrwcm	62	3	cell	cell	NN
cord-252443-lclxrwcm	62	4	responses	response	NNS
cord-252443-lclxrwcm	62	5	,	,	,
cord-252443-lclxrwcm	62	6	particularly	particularly	RB
cord-252443-lclxrwcm	62	7	against	against	IN
cord-252443-lclxrwcm	62	8	relatively	relatively	RB
cord-252443-lclxrwcm	62	9	well	well	RB
cord-252443-lclxrwcm	62	10	-	-	HYPH
cord-252443-lclxrwcm	62	11	conserved	conserve	VBN
cord-252443-lclxrwcm	62	12	internal	internal	JJ
cord-252443-lclxrwcm	62	13	influenza	influenza	NN
cord-252443-lclxrwcm	62	14	antigens	antigen	NNS
cord-252443-lclxrwcm	62	15	,	,	,
cord-252443-lclxrwcm	62	16	can	can	MD
cord-252443-lclxrwcm	62	17	efficaciously	efficaciously	RB
cord-252443-lclxrwcm	62	18	provide	provide	VB
cord-252443-lclxrwcm	62	19	crossclade	crossclade	NNP
cord-252443-lclxrwcm	62	20	protection	protection	NN
cord-252443-lclxrwcm	62	21	(	(	-LRB-
cord-252443-lclxrwcm	62	22	38	38	CD
cord-252443-lclxrwcm	62	23	,	,	,
cord-252443-lclxrwcm	62	24	41	41	CD
cord-252443-lclxrwcm	62	25	,	,	,
cord-252443-lclxrwcm	62	26	42	42	CD
cord-252443-lclxrwcm	62	27	)	)	-RRB-
cord-252443-lclxrwcm	62	28	.	.	.
cord-252443-lclxrwcm	63	1	Although	although	IN
cord-252443-lclxrwcm	63	2	human	human	JJ
cord-252443-lclxrwcm	63	3	cytotoxic	cytotoxic	JJ
cord-252443-lclxrwcm	63	4	T	t	NN
cord-252443-lclxrwcm	63	5	-	-	HYPH
cord-252443-lclxrwcm	63	6	lymphocyte	lymphocyte	NN
cord-252443-lclxrwcm	63	7	(	(	-LRB-
cord-252443-lclxrwcm	63	8	CTL	CTL	NNP
cord-252443-lclxrwcm	63	9	)	)	-RRB-
cord-252443-lclxrwcm	63	10	immunity	immunity	NN
cord-252443-lclxrwcm	63	11	declines	decline	NNS
cord-252443-lclxrwcm	63	12	during	during	IN
cord-252443-lclxrwcm	63	13	periods	period	NNS
cord-252443-lclxrwcm	63	14	of	of	IN
cord-252443-lclxrwcm	63	15	low	low	JJ
cord-252443-lclxrwcm	63	16	influenza	influenza	NN
cord-252443-lclxrwcm	63	17	prevalence	prevalence	NN
cord-252443-lclxrwcm	63	18	,	,	,
cord-252443-lclxrwcm	63	19	these	these	DT
cord-252443-lclxrwcm	63	20	cells	cell	NNS
cord-252443-lclxrwcm	63	21	are	be	VBP
cord-252443-lclxrwcm	63	22	still	still	RB
cord-252443-lclxrwcm	63	23	detectable	detectable	JJ
cord-252443-lclxrwcm	63	24	after	after	IN
cord-252443-lclxrwcm	63	25	5	5	CD
cord-252443-lclxrwcm	63	26	years	year	NNS
cord-252443-lclxrwcm	63	27	,	,	,
cord-252443-lclxrwcm	63	28	with	with	IN
cord-252443-lclxrwcm	63	29	an	an	DT
cord-252443-lclxrwcm	63	30	estimated	estimate	VBN
cord-252443-lclxrwcm	63	31	half	half	JJ
cord-252443-lclxrwcm	63	32	-	-	HYPH
cord-252443-lclxrwcm	63	33	life	life	NN
cord-252443-lclxrwcm	63	34	of	of	IN
cord-252443-lclxrwcm	63	35	2	2	CD
cord-252443-lclxrwcm	63	36	-	-	SYM
cord-252443-lclxrwcm	63	37	3	3	CD
cord-252443-lclxrwcm	63	38	years	year	NNS
cord-252443-lclxrwcm	63	39	(	(	-LRB-
cord-252443-lclxrwcm	63	40	43	43	CD
cord-252443-lclxrwcm	63	41	)	)	-RRB-
cord-252443-lclxrwcm	63	42	,	,	,
cord-252443-lclxrwcm	63	43	making	make	VBG
cord-252443-lclxrwcm	63	44	these	these	DT
cord-252443-lclxrwcm	63	45	cells	cell	NNS
cord-252443-lclxrwcm	63	46	an	an	DT
cord-252443-lclxrwcm	63	47	ideal	ideal	JJ
cord-252443-lclxrwcm	63	48	target	target	NN
cord-252443-lclxrwcm	63	49	for	for	IN
cord-252443-lclxrwcm	63	50	boosting	boost	VBG
cord-252443-lclxrwcm	63	51	through	through	IN
cord-252443-lclxrwcm	63	52	vaccination	vaccination	NN
cord-252443-lclxrwcm	63	53	.	.	.
cord-252443-lclxrwcm	64	1	Although	although	IN
cord-252443-lclxrwcm	64	2	cellular	cellular	JJ
cord-252443-lclxrwcm	64	3	immunity	immunity	NN
cord-252443-lclxrwcm	64	4	does	do	VBZ
cord-252443-lclxrwcm	64	5	not	not	RB
cord-252443-lclxrwcm	64	6	prevent	prevent	VB
cord-252443-lclxrwcm	64	7	viral	viral	JJ
cord-252443-lclxrwcm	64	8	infection	infection	NN
cord-252443-lclxrwcm	64	9	,	,	,
cord-252443-lclxrwcm	64	10	it	-PRON-	PRP
cord-252443-lclxrwcm	64	11	is	be	VBZ
cord-252443-lclxrwcm	64	12	important	important	JJ
cord-252443-lclxrwcm	64	13	in	in	IN
cord-252443-lclxrwcm	64	14	clearing	clear	VBG
cord-252443-lclxrwcm	64	15	and	and	CC
cord-252443-lclxrwcm	64	16	curtailing	curtail	VBG
cord-252443-lclxrwcm	64	17	infection	infection	NN
cord-252443-lclxrwcm	64	18	.	.	.
cord-252443-lclxrwcm	65	1	Cytotoxic	Cytotoxic	NNP
cord-252443-lclxrwcm	65	2	CD8	CD8	NNP
cord-252443-lclxrwcm	65	3	+	+	CC
cord-252443-lclxrwcm	65	4	T	t	NN
cord-252443-lclxrwcm	65	5	cells	cell	NNS
cord-252443-lclxrwcm	65	6	play	play	VBP
cord-252443-lclxrwcm	65	7	a	a	DT
cord-252443-lclxrwcm	65	8	major	major	JJ
cord-252443-lclxrwcm	65	9	role	role	NN
cord-252443-lclxrwcm	65	10	and	and	CC
cord-252443-lclxrwcm	65	11	can	can	MD
cord-252443-lclxrwcm	65	12	eliminate	eliminate	VB
cord-252443-lclxrwcm	65	13	virally	virally	RB
cord-252443-lclxrwcm	65	14	infected	infect	VBN
cord-252443-lclxrwcm	65	15	cells	cell	NNS
cord-252443-lclxrwcm	65	16	(	(	-LRB-
cord-252443-lclxrwcm	65	17	44	44	CD
cord-252443-lclxrwcm	65	18	,	,	,
cord-252443-lclxrwcm	65	19	45	45	CD
cord-252443-lclxrwcm	65	20	)	)	-RRB-
cord-252443-lclxrwcm	65	21	.	.	.
cord-252443-lclxrwcm	66	1	A	a	DT
cord-252443-lclxrwcm	66	2	direct	direct	JJ
cord-252443-lclxrwcm	66	3	cytolytic	cytolytic	JJ
cord-252443-lclxrwcm	66	4	role	role	NN
cord-252443-lclxrwcm	66	5	for	for	IN
cord-252443-lclxrwcm	66	6	CD4	CD4	NNP
cord-252443-lclxrwcm	66	7	+	+	CC
cord-252443-lclxrwcm	66	8	T	t	NN
cord-252443-lclxrwcm	66	9	cells	cell	NNS
cord-252443-lclxrwcm	66	10	has	have	VBZ
cord-252443-lclxrwcm	66	11	been	be	VBN
cord-252443-lclxrwcm	66	12	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	66	13	(	(	-LRB-
cord-252443-lclxrwcm	66	14	25	25	CD
cord-252443-lclxrwcm	66	15	,	,	,
cord-252443-lclxrwcm	66	16	46	46	CD
cord-252443-lclxrwcm	66	17	)	)	-RRB-
cord-252443-lclxrwcm	66	18	.	.	.
cord-252443-lclxrwcm	67	1	More	more	RBR
cord-252443-lclxrwcm	67	2	importantly	importantly	RB
cord-252443-lclxrwcm	67	3	,	,	,
cord-252443-lclxrwcm	67	4	CD4	CD4	NNP
cord-252443-lclxrwcm	67	5	+	+	CC
cord-252443-lclxrwcm	67	6	T	t	NN
cord-252443-lclxrwcm	67	7	cells	cell	NNS
cord-252443-lclxrwcm	67	8	can	can	MD
cord-252443-lclxrwcm	67	9	provide	provide	VB
cord-252443-lclxrwcm	67	10	B	b	NN
cord-252443-lclxrwcm	67	11	-	-	HYPH
cord-252443-lclxrwcm	67	12	cell	cell	NN
cord-252443-lclxrwcm	67	13	help	help	NN
cord-252443-lclxrwcm	67	14	,	,	,
cord-252443-lclxrwcm	67	15	and	and	CC
cord-252443-lclxrwcm	67	16	prior	prior	RB
cord-252443-lclxrwcm	67	17	CD4	CD4	NNP
cord-252443-lclxrwcm	67	18	+	+	CC
cord-252443-lclxrwcm	67	19	T	t	NN
cord-252443-lclxrwcm	67	20	-	-	HYPH
cord-252443-lclxrwcm	67	21	cell	cell	NN
cord-252443-lclxrwcm	67	22	immunity	immunity	NN
cord-252443-lclxrwcm	67	23	can	can	MD
cord-252443-lclxrwcm	67	24	efficaciously	efficaciously	RB
cord-252443-lclxrwcm	67	25	augment	augment	VB
cord-252443-lclxrwcm	67	26	HAspecific	HAspecific	NNP
cord-252443-lclxrwcm	67	27	antibody	antibody	NN
cord-252443-lclxrwcm	67	28	responses	response	NNS
cord-252443-lclxrwcm	67	29	(	(	-LRB-
cord-252443-lclxrwcm	67	30	47	47	CD
cord-252443-lclxrwcm	67	31	,	,	,
cord-252443-lclxrwcm	67	32	48	48	CD
cord-252443-lclxrwcm	67	33	)	)	-RRB-
cord-252443-lclxrwcm	67	34	.	.	.
cord-252443-lclxrwcm	68	1	Unfortunately	unfortunately	RB
cord-252443-lclxrwcm	68	2	,	,	,
cord-252443-lclxrwcm	68	3	even	even	RB
cord-252443-lclxrwcm	68	4	though	though	IN
cord-252443-lclxrwcm	68	5	inactivated	inactivate	VBN
cord-252443-lclxrwcm	68	6	influenza	influenza	NN
cord-252443-lclxrwcm	68	7	vaccines	vaccine	NNS
cord-252443-lclxrwcm	68	8	routinely	routinely	RB
cord-252443-lclxrwcm	68	9	contain	contain	VBP
cord-252443-lclxrwcm	68	10	internal	internal	JJ
cord-252443-lclxrwcm	68	11	influenza	influenza	NN
cord-252443-lclxrwcm	68	12	antigens	antigen	NNS
cord-252443-lclxrwcm	68	13	,	,	,
cord-252443-lclxrwcm	68	14	specifically	specifically	RB
cord-252443-lclxrwcm	68	15	nucleoprotein	nucleoprotein	NNP
cord-252443-lclxrwcm	68	16	and	and	CC
cord-252443-lclxrwcm	68	17	matrix	matrix	NN
cord-252443-lclxrwcm	68	18	protein	protein	NN
cord-252443-lclxrwcm	68	19	1	1	CD
cord-252443-lclxrwcm	68	20	(	(	-LRB-
cord-252443-lclxrwcm	68	21	49	49	CD
cord-252443-lclxrwcm	68	22	,	,	,
cord-252443-lclxrwcm	68	23	50	50	CD
cord-252443-lclxrwcm	68	24	)	)	-RRB-
cord-252443-lclxrwcm	68	25	,	,	,
cord-252443-lclxrwcm	68	26	these	these	DT
cord-252443-lclxrwcm	68	27	vaccines	vaccine	NNS
cord-252443-lclxrwcm	68	28	do	do	VBP
cord-252443-lclxrwcm	68	29	not	not	RB
cord-252443-lclxrwcm	68	30	boost	boost	VB
cord-252443-lclxrwcm	68	31	cellular	cellular	JJ
cord-252443-lclxrwcm	68	32	immunity	immunity	NN
cord-252443-lclxrwcm	68	33	to	to	IN
cord-252443-lclxrwcm	68	34	an	an	DT
cord-252443-lclxrwcm	68	35	efficacious	efficacious	JJ
cord-252443-lclxrwcm	68	36	level	level	NN
cord-252443-lclxrwcm	68	37	(	(	-LRB-
cord-252443-lclxrwcm	68	38	49	49	CD
cord-252443-lclxrwcm	68	39	,	,	,
cord-252443-lclxrwcm	68	40	51	51	CD
cord-252443-lclxrwcm	68	41	)	)	-RRB-
cord-252443-lclxrwcm	68	42	.	.	.
cord-252443-lclxrwcm	69	1	Prediction	prediction	NN
cord-252443-lclxrwcm	69	2	of	of	IN
cord-252443-lclxrwcm	69	3	the	the	DT
cord-252443-lclxrwcm	69	4	major	major	JJ
cord-252443-lclxrwcm	69	5	circulating	circulate	VBG
cord-252443-lclxrwcm	69	6	influenza	influenza	NN
cord-252443-lclxrwcm	69	7	subtypes	subtype	NNS
cord-252443-lclxrwcm	69	8	on	on	IN
cord-252443-lclxrwcm	69	9	the	the	DT
cord-252443-lclxrwcm	69	10	basis	basis	NN
cord-252443-lclxrwcm	69	11	of	of	IN
cord-252443-lclxrwcm	69	12	routine	routine	JJ
cord-252443-lclxrwcm	69	13	surveillance	surveillance	NN
cord-252443-lclxrwcm	69	14	-	-	HYPH
cord-252443-lclxrwcm	69	15	required	require	VBN
cord-252443-lclxrwcm	69	16	to	to	TO
cord-252443-lclxrwcm	69	17	update	update	VB
cord-252443-lclxrwcm	69	18	influenza	influenza	NN
cord-252443-lclxrwcm	69	19	vaccines	vaccine	NNS
cord-252443-lclxrwcm	69	20	each	each	DT
cord-252443-lclxrwcm	69	21	year	year	NN
cord-252443-lclxrwcm	69	22	-	-	:
cord-252443-lclxrwcm	69	23	can	can	MD
cord-252443-lclxrwcm	69	24	fail	fail	VB
cord-252443-lclxrwcm	69	25	.	.	.
cord-252443-lclxrwcm	70	1	Indeed	indeed	RB
cord-252443-lclxrwcm	70	2	,	,	,
cord-252443-lclxrwcm	70	3	mismatch	mismatch	NN
cord-252443-lclxrwcm	70	4	between	between	IN
cord-252443-lclxrwcm	70	5	the	the	DT
cord-252443-lclxrwcm	70	6	vaccine	vaccine	NN
cord-252443-lclxrwcm	70	7	components	component	NNS
cord-252443-lclxrwcm	70	8	and	and	CC
cord-252443-lclxrwcm	70	9	circulating	circulate	VBG
cord-252443-lclxrwcm	70	10	virus	virus	NN
cord-252443-lclxrwcm	70	11	occurs	occur	VBZ
cord-252443-lclxrwcm	70	12	approximately	approximately	RB
cord-252443-lclxrwcm	70	13	every	every	DT
cord-252443-lclxrwcm	70	14	3	3	CD
cord-252443-lclxrwcm	70	15	-	-	SYM
cord-252443-lclxrwcm	70	16	4	4	CD
cord-252443-lclxrwcm	70	17	years	year	NNS
cord-252443-lclxrwcm	70	18	(	(	-LRB-
cord-252443-lclxrwcm	70	19	52	52	CD
cord-252443-lclxrwcm	70	20	,	,	,
cord-252443-lclxrwcm	70	21	53	53	CD
cord-252443-lclxrwcm	70	22	)	)	-RRB-
cord-252443-lclxrwcm	70	23	.	.	.
cord-252443-lclxrwcm	71	1	This	this	DT
cord-252443-lclxrwcm	71	2	mismatch	mismatch	NN
cord-252443-lclxrwcm	71	3	has	have	VBZ
cord-252443-lclxrwcm	71	4	a	a	DT
cord-252443-lclxrwcm	71	5	significant	significant	JJ
cord-252443-lclxrwcm	71	6	effect	effect	NN
cord-252443-lclxrwcm	71	7	on	on	IN
cord-252443-lclxrwcm	71	8	vaccine	vaccine	NN
cord-252443-lclxrwcm	71	9	efficacy	efficacy	NN
cord-252443-lclxrwcm	71	10	;	;	:
cord-252443-lclxrwcm	71	11	in	in	IN
cord-252443-lclxrwcm	71	12	healthy	healthy	JJ
cord-252443-lclxrwcm	71	13	adults	adult	NNS
cord-252443-lclxrwcm	71	14	,	,	,
cord-252443-lclxrwcm	71	15	parenteral	parenteral	JJ
cord-252443-lclxrwcm	71	16	vaccine	vaccine	NN
cord-252443-lclxrwcm	71	17	efficacy	efficacy	NN
cord-252443-lclxrwcm	71	18	against	against	IN
cord-252443-lclxrwcm	71	19	seasonal	seasonal	JJ
cord-252443-lclxrwcm	71	20	influenza	influenza	NN
cord-252443-lclxrwcm	71	21	is	be	VBZ
cord-252443-lclxrwcm	71	22	approximately	approximately	RB
cord-252443-lclxrwcm	71	23	75	75	CD
cord-252443-lclxrwcm	71	24	%	%	NN
cord-252443-lclxrwcm	71	25	when	when	WRB
cord-252443-lclxrwcm	71	26	the	the	DT
cord-252443-lclxrwcm	71	27	circulating	circulate	VBG
cord-252443-lclxrwcm	71	28	influenza	influenza	NN
cord-252443-lclxrwcm	71	29	and	and	CC
cord-252443-lclxrwcm	71	30	vaccine	vaccine	NN
cord-252443-lclxrwcm	71	31	strain	strain	NN
cord-252443-lclxrwcm	71	32	match	match	NN
cord-252443-lclxrwcm	71	33	;	;	:
cord-252443-lclxrwcm	71	34	however	however	RB
cord-252443-lclxrwcm	71	35	,	,	,
cord-252443-lclxrwcm	71	36	efficacy	efficacy	NN
cord-252443-lclxrwcm	71	37	decreases	decrease	VBZ
cord-252443-lclxrwcm	71	38	to	to	IN
cord-252443-lclxrwcm	71	39	44	44	CD
cord-252443-lclxrwcm	71	40	%	%	NN
cord-252443-lclxrwcm	71	41	when	when	WRB
cord-252443-lclxrwcm	71	42	mismatch	mismatch	NN
cord-252443-lclxrwcm	71	43	occurs	occur	VBZ
cord-252443-lclxrwcm	71	44	(	(	-LRB-
cord-252443-lclxrwcm	71	45	30	30	CD
cord-252443-lclxrwcm	71	46	)	)	-RRB-
cord-252443-lclxrwcm	71	47	.	.	.
cord-252443-lclxrwcm	72	1	Substantial	substantial	JJ
cord-252443-lclxrwcm	72	2	costs	cost	NNS
cord-252443-lclxrwcm	72	3	are	be	VBP
cord-252443-lclxrwcm	72	4	incurred	incur	VBN
cord-252443-lclxrwcm	72	5	because	because	IN
cord-252443-lclxrwcm	72	6	of	of	IN
cord-252443-lclxrwcm	72	7	the	the	DT
cord-252443-lclxrwcm	72	8	need	need	NN
cord-252443-lclxrwcm	72	9	for	for	IN
cord-252443-lclxrwcm	72	10	annual	annual	JJ
cord-252443-lclxrwcm	72	11	reformulation	reformulation	NN
cord-252443-lclxrwcm	72	12	and	and	CC
cord-252443-lclxrwcm	72	13	given	give	VBN
cord-252443-lclxrwcm	72	14	the	the	DT
cord-252443-lclxrwcm	72	15	manufacturing	manufacturing	NN
cord-252443-lclxrwcm	72	16	process	process	NN
cord-252443-lclxrwcm	72	17	,	,	,
cord-252443-lclxrwcm	72	18	which	which	WDT
cord-252443-lclxrwcm	72	19	for	for	IN
cord-252443-lclxrwcm	72	20	the	the	DT
cord-252443-lclxrwcm	72	21	recent	recent	JJ
cord-252443-lclxrwcm	72	22	2009	2009	CD
cord-252443-lclxrwcm	72	23	H1N1	H1N1	NNP
cord-252443-lclxrwcm	72	24	pandemic	pandemic	NN
cord-252443-lclxrwcm	72	25	took	take	VBD
cord-252443-lclxrwcm	72	26	over	over	RP
cord-252443-lclxrwcm	72	27	6	6	CD
cord-252443-lclxrwcm	72	28	months	month	NNS
cord-252443-lclxrwcm	72	29	even	even	RB
cord-252443-lclxrwcm	72	30	with	with	IN
cord-252443-lclxrwcm	72	31	the	the	DT
cord-252443-lclxrwcm	72	32	implemented	implement	VBN
cord-252443-lclxrwcm	72	33	pandemic	pandemic	JJ
cord-252443-lclxrwcm	72	34	readiness	readiness	NN
cord-252443-lclxrwcm	72	35	plans	plan	NNS
cord-252443-lclxrwcm	72	36	(	(	-LRB-
cord-252443-lclxrwcm	72	37	54	54	CD
cord-252443-lclxrwcm	72	38	)	)	-RRB-
cord-252443-lclxrwcm	72	39	.	.	.
cord-252443-lclxrwcm	73	1	Each	each	DT
cord-252443-lclxrwcm	73	2	year	year	NN
cord-252443-lclxrwcm	73	3	,	,	,
cord-252443-lclxrwcm	73	4	there	there	EX
cord-252443-lclxrwcm	73	5	is	be	VBZ
cord-252443-lclxrwcm	73	6	essentially	essentially	RB
cord-252443-lclxrwcm	73	7	a	a	DT
cord-252443-lclxrwcm	73	8	race	race	NN
cord-252443-lclxrwcm	73	9	between	between	IN
cord-252443-lclxrwcm	73	10	production	production	NN
cord-252443-lclxrwcm	73	11	,	,	,
cord-252443-lclxrwcm	73	12	deployment	deployment	NN
cord-252443-lclxrwcm	73	13	and	and	CC
cord-252443-lclxrwcm	73	14	the	the	DT
cord-252443-lclxrwcm	73	15	spread	spread	NN
cord-252443-lclxrwcm	73	16	of	of	IN
cord-252443-lclxrwcm	73	17	infection	infection	NN
cord-252443-lclxrwcm	73	18	.	.	.
cord-252443-lclxrwcm	74	1	One	one	CD
cord-252443-lclxrwcm	74	2	of	of	IN
cord-252443-lclxrwcm	74	3	the	the	DT
cord-252443-lclxrwcm	74	4	main	main	JJ
cord-252443-lclxrwcm	74	5	challenges	challenge	NNS
cord-252443-lclxrwcm	74	6	for	for	IN
cord-252443-lclxrwcm	74	7	inducing	induce	VBG
cord-252443-lclxrwcm	74	8	strong	strong	JJ
cord-252443-lclxrwcm	74	9	immune	immune	JJ
cord-252443-lclxrwcm	74	10	responses	response	NNS
cord-252443-lclxrwcm	74	11	following	follow	VBG
cord-252443-lclxrwcm	74	12	vaccination	vaccination	NN
cord-252443-lclxrwcm	74	13	with	with	IN
cord-252443-lclxrwcm	74	14	inactivated	inactivated	JJ
cord-252443-lclxrwcm	74	15	or	or	CC
cord-252443-lclxrwcm	74	16	subunit	subunit	NN
cord-252443-lclxrwcm	74	17	protein	protein	NN
cord-252443-lclxrwcm	74	18	vaccines	vaccine	NNS
cord-252443-lclxrwcm	74	19	is	be	VBZ
cord-252443-lclxrwcm	74	20	the	the	DT
cord-252443-lclxrwcm	74	21	inherent	inherent	JJ
cord-252443-lclxrwcm	74	22	poor	poor	JJ
cord-252443-lclxrwcm	74	23	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	74	24	of	of	IN
cord-252443-lclxrwcm	74	25	proteins	protein	NNS
cord-252443-lclxrwcm	74	26	,	,	,
cord-252443-lclxrwcm	74	27	which	which	WDT
cord-252443-lclxrwcm	74	28	can	can	MD
cord-252443-lclxrwcm	74	29	be	be	VB
cord-252443-lclxrwcm	74	30	partially	partially	RB
cord-252443-lclxrwcm	74	31	overcome	overcome	VBN
cord-252443-lclxrwcm	74	32	by	by	IN
cord-252443-lclxrwcm	74	33	the	the	DT
cord-252443-lclxrwcm	74	34	addition	addition	NN
cord-252443-lclxrwcm	74	35	of	of	IN
cord-252443-lclxrwcm	74	36	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	74	37	.	.	.
cord-252443-lclxrwcm	75	1	Adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	75	2	are	be	VBP
cord-252443-lclxrwcm	75	3	a	a	DT
cord-252443-lclxrwcm	75	4	common	common	JJ
cord-252443-lclxrwcm	75	5	means	mean	NNS
cord-252443-lclxrwcm	75	6	to	to	TO
cord-252443-lclxrwcm	75	7	augment	augment	VB
cord-252443-lclxrwcm	75	8	adaptive	adaptive	JJ
cord-252443-lclxrwcm	75	9	immune	immune	JJ
cord-252443-lclxrwcm	75	10	responses	response	NNS
cord-252443-lclxrwcm	75	11	to	to	IN
cord-252443-lclxrwcm	75	12	vaccines	vaccine	NNS
cord-252443-lclxrwcm	75	13	and	and	CC
cord-252443-lclxrwcm	75	14	can	can	MD
cord-252443-lclxrwcm	75	15	be	be	VB
cord-252443-lclxrwcm	75	16	broadly	broadly	RB
cord-252443-lclxrwcm	75	17	classified	classify	VBN
cord-252443-lclxrwcm	75	18	into	into	IN
cord-252443-lclxrwcm	75	19	vehicles	vehicle	NNS
cord-252443-lclxrwcm	75	20	or	or	CC
cord-252443-lclxrwcm	75	21	immunostimulants	immunostimulant	NNS
cord-252443-lclxrwcm	75	22	(	(	-LRB-
cord-252443-lclxrwcm	75	23	55	55	CD
cord-252443-lclxrwcm	75	24	)	)	-RRB-
cord-252443-lclxrwcm	75	25	.	.	.
cord-252443-lclxrwcm	76	1	The	the	DT
cord-252443-lclxrwcm	76	2	former	former	JJ
cord-252443-lclxrwcm	76	3	group	group	NN
cord-252443-lclxrwcm	76	4	largely	largely	RB
cord-252443-lclxrwcm	76	5	enhance	enhance	VBP
cord-252443-lclxrwcm	76	6	presentation	presentation	NN
cord-252443-lclxrwcm	76	7	to	to	IN
cord-252443-lclxrwcm	76	8	the	the	DT
cord-252443-lclxrwcm	76	9	immune	immune	JJ
cord-252443-lclxrwcm	76	10	system	system	NN
cord-252443-lclxrwcm	76	11	,	,	,
cord-252443-lclxrwcm	76	12	whereas	whereas	IN
cord-252443-lclxrwcm	76	13	the	the	DT
cord-252443-lclxrwcm	76	14	latter	latter	JJ
cord-252443-lclxrwcm	76	15	enhance	enhance	VBP
cord-252443-lclxrwcm	76	16	the	the	DT
cord-252443-lclxrwcm	76	17	adaptive	adaptive	JJ
cord-252443-lclxrwcm	76	18	immune	immune	JJ
cord-252443-lclxrwcm	76	19	response	response	NN
cord-252443-lclxrwcm	76	20	(	(	-LRB-
cord-252443-lclxrwcm	76	21	55	55	CD
cord-252443-lclxrwcm	76	22	)	)	-RRB-
cord-252443-lclxrwcm	76	23	(	(	-LRB-
cord-252443-lclxrwcm	76	24	56	56	CD
cord-252443-lclxrwcm	76	25	)	)	-RRB-
cord-252443-lclxrwcm	76	26	(	(	-LRB-
cord-252443-lclxrwcm	76	27	57	57	CD
cord-252443-lclxrwcm	76	28	)	)	-RRB-
cord-252443-lclxrwcm	76	29	.	.	.
cord-252443-lclxrwcm	77	1	Some	some	DT
cord-252443-lclxrwcm	77	2	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	77	3	have	have	VBP
cord-252443-lclxrwcm	77	4	been	be	VBN
cord-252443-lclxrwcm	77	5	shown	show	VBN
cord-252443-lclxrwcm	77	6	to	to	TO
cord-252443-lclxrwcm	77	7	advantageously	advantageously	RB
cord-252443-lclxrwcm	77	8	increase	increase	VB
cord-252443-lclxrwcm	77	9	and	and	CC
cord-252443-lclxrwcm	77	10	broaden	broaden	VB
cord-252443-lclxrwcm	77	11	the	the	DT
cord-252443-lclxrwcm	77	12	epitopes	epitope	NNS
cord-252443-lclxrwcm	77	13	recognized	recognize	VBN
cord-252443-lclxrwcm	77	14	by	by	IN
cord-252443-lclxrwcm	77	15	the	the	DT
cord-252443-lclxrwcm	77	16	immune	immune	JJ
cord-252443-lclxrwcm	77	17	repertoire	repertoire	NN
cord-252443-lclxrwcm	77	18	(	(	-LRB-
cord-252443-lclxrwcm	77	19	58	58	CD
cord-252443-lclxrwcm	77	20	,	,	,
cord-252443-lclxrwcm	77	21	59	59	CD
cord-252443-lclxrwcm	77	22	)	)	-RRB-
cord-252443-lclxrwcm	77	23	.	.	.
cord-252443-lclxrwcm	78	1	A	a	DT
cord-252443-lclxrwcm	78	2	number	number	NN
cord-252443-lclxrwcm	78	3	of	of	IN
cord-252443-lclxrwcm	78	4	strategies	strategy	NNS
cord-252443-lclxrwcm	78	5	have	have	VBP
cord-252443-lclxrwcm	78	6	been	be	VBN
cord-252443-lclxrwcm	78	7	deployed	deploy	VBN
cord-252443-lclxrwcm	78	8	to	to	TO
cord-252443-lclxrwcm	78	9	improve	improve	VB
cord-252443-lclxrwcm	78	10	influenza	influenza	NN
cord-252443-lclxrwcm	78	11	vaccine	vaccine	NN
cord-252443-lclxrwcm	78	12	efficacy	efficacy	NN
cord-252443-lclxrwcm	78	13	for	for	IN
cord-252443-lclxrwcm	78	14	the	the	DT
cord-252443-lclxrwcm	78	15	elderly	elderly	JJ
cord-252443-lclxrwcm	78	16	,	,	,
cord-252443-lclxrwcm	78	17	and	and	CC
cord-252443-lclxrwcm	78	18	the	the	DT
cord-252443-lclxrwcm	78	19	inclusion	inclusion	NN
cord-252443-lclxrwcm	78	20	of	of	IN
cord-252443-lclxrwcm	78	21	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	78	22	as	as	IN
cord-252443-lclxrwcm	78	23	a	a	DT
cord-252443-lclxrwcm	78	24	means	means	NN
cord-252443-lclxrwcm	78	25	to	to	TO
cord-252443-lclxrwcm	78	26	augment	augment	VB
cord-252443-lclxrwcm	78	27	humoral	humoral	JJ
cord-252443-lclxrwcm	78	28	immunity	immunity	NN
cord-252443-lclxrwcm	78	29	in	in	IN
cord-252443-lclxrwcm	78	30	the	the	DT
cord-252443-lclxrwcm	78	31	elderly	elderly	JJ
cord-252443-lclxrwcm	78	32	has	have	VBZ
cord-252443-lclxrwcm	78	33	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	78	34	relatively	relatively	RB
cord-252443-lclxrwcm	78	35	encouraging	encouraging	JJ
cord-252443-lclxrwcm	78	36	results	result	NNS
cord-252443-lclxrwcm	78	37	(	(	-LRB-
cord-252443-lclxrwcm	78	38	60	60	CD
cord-252443-lclxrwcm	78	39	,	,	,
cord-252443-lclxrwcm	78	40	61	61	CD
cord-252443-lclxrwcm	78	41	)	)	-RRB-
cord-252443-lclxrwcm	78	42	.	.	.
cord-252443-lclxrwcm	79	1	Another	another	DT
cord-252443-lclxrwcm	79	2	challenge	challenge	NN
cord-252443-lclxrwcm	79	3	is	be	VBZ
cord-252443-lclxrwcm	79	4	the	the	DT
cord-252443-lclxrwcm	79	5	long	long	JJ
cord-252443-lclxrwcm	79	6	-	-	HYPH
cord-252443-lclxrwcm	79	7	term	term	NN
cord-252443-lclxrwcm	79	8	stability	stability	NN
cord-252443-lclxrwcm	79	9	of	of	IN
cord-252443-lclxrwcm	79	10	recombinant	recombinant	JJ
cord-252443-lclxrwcm	79	11	proteins	protein	NNS
cord-252443-lclxrwcm	79	12	;	;	:
cord-252443-lclxrwcm	79	13	the	the	DT
cord-252443-lclxrwcm	79	14	inclusion	inclusion	NN
cord-252443-lclxrwcm	79	15	of	of	IN
cord-252443-lclxrwcm	79	16	some	some	DT
cord-252443-lclxrwcm	79	17	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	79	18	can	can	MD
cord-252443-lclxrwcm	79	19	facilitate	facilitate	VB
cord-252443-lclxrwcm	79	20	increased	increase	VBN
cord-252443-lclxrwcm	79	21	vaccine	vaccine	NN
cord-252443-lclxrwcm	79	22	stability	stability	NN
cord-252443-lclxrwcm	79	23	during	during	IN
cord-252443-lclxrwcm	79	24	storage	storage	NN
cord-252443-lclxrwcm	79	25	or	or	CC
cord-252443-lclxrwcm	79	26	upon	upon	IN
cord-252443-lclxrwcm	79	27	injection	injection	NN
cord-252443-lclxrwcm	79	28	(	(	-LRB-
cord-252443-lclxrwcm	79	29	62	62	CD
cord-252443-lclxrwcm	79	30	)	)	-RRB-
cord-252443-lclxrwcm	79	31	.	.	.
cord-252443-lclxrwcm	80	1	However	however	RB
cord-252443-lclxrwcm	80	2	,	,	,
cord-252443-lclxrwcm	80	3	even	even	RB
cord-252443-lclxrwcm	80	4	with	with	IN
cord-252443-lclxrwcm	80	5	this	this	DT
cord-252443-lclxrwcm	80	6	augmented	augment	VBN
cord-252443-lclxrwcm	80	7	stability	stability	NN
cord-252443-lclxrwcm	80	8	there	there	EX
cord-252443-lclxrwcm	80	9	are	be	VBP
cord-252443-lclxrwcm	80	10	often	often	RB
cord-252443-lclxrwcm	80	11	thermostability	thermostability	NN
cord-252443-lclxrwcm	80	12	difficulties	difficulty	NNS
cord-252443-lclxrwcm	80	13	,	,	,
cord-252443-lclxrwcm	80	14	especially	especially	RB
cord-252443-lclxrwcm	80	15	when	when	WRB
cord-252443-lclxrwcm	80	16	vaccines	vaccine	NNS
cord-252443-lclxrwcm	80	17	occupy	occupy	VBP
cord-252443-lclxrwcm	80	18	a	a	DT
cord-252443-lclxrwcm	80	19	large	large	JJ
cord-252443-lclxrwcm	80	20	amount	amount	NN
cord-252443-lclxrwcm	80	21	of	of	IN
cord-252443-lclxrwcm	80	22	cold	cold	JJ
cord-252443-lclxrwcm	80	23	-	-	HYPH
cord-252443-lclxrwcm	80	24	chain	chain	NN
cord-252443-lclxrwcm	80	25	storage	storage	NN
cord-252443-lclxrwcm	80	26	space	space	NN
cord-252443-lclxrwcm	80	27	due	due	JJ
cord-252443-lclxrwcm	80	28	to	to	IN
cord-252443-lclxrwcm	80	29	relatively	relatively	RB
cord-252443-lclxrwcm	80	30	complex	complex	JJ
cord-252443-lclxrwcm	80	31	administration	administration	NN
cord-252443-lclxrwcm	80	32	or	or	CC
cord-252443-lclxrwcm	80	33	dosing	dose	VBG
cord-252443-lclxrwcm	80	34	regimens	regimen	NNS
cord-252443-lclxrwcm	80	35	.	.	.
cord-252443-lclxrwcm	81	1	There	there	EX
cord-252443-lclxrwcm	81	2	are	be	VBP
cord-252443-lclxrwcm	81	3	a	a	DT
cord-252443-lclxrwcm	81	4	number	number	NN
cord-252443-lclxrwcm	81	5	of	of	IN
cord-252443-lclxrwcm	81	6	platforms	platform	NNS
cord-252443-lclxrwcm	81	7	being	be	VBG
cord-252443-lclxrwcm	81	8	explored	explore	VBN
cord-252443-lclxrwcm	81	9	for	for	IN
cord-252443-lclxrwcm	81	10	more	more	RBR
cord-252443-lclxrwcm	81	11	efficacious	efficacious	JJ
cord-252443-lclxrwcm	81	12	influenza	influenza	NN
cord-252443-lclxrwcm	81	13	vaccine	vaccine	NN
cord-252443-lclxrwcm	81	14	delivery	delivery	NN
cord-252443-lclxrwcm	81	15	and	and	CC
cord-252443-lclxrwcm	81	16	these	these	DT
cord-252443-lclxrwcm	81	17	can	can	MD
cord-252443-lclxrwcm	81	18	be	be	VB
cord-252443-lclxrwcm	81	19	broadly	broadly	RB
cord-252443-lclxrwcm	81	20	classified	classify	VBN
cord-252443-lclxrwcm	81	21	into	into	IN
cord-252443-lclxrwcm	81	22	:	:	:
cord-252443-lclxrwcm	81	23	recombinant	recombinant	JJ
cord-252443-lclxrwcm	81	24	protein/	protein/	POS
cord-252443-lclxrwcm	81	25	peptide	peptide	NN
cord-252443-lclxrwcm	81	26	,	,	,
cord-252443-lclxrwcm	81	27	DNA	dna	NN
cord-252443-lclxrwcm	81	28	vaccines	vaccine	NNS
cord-252443-lclxrwcm	81	29	,	,	,
cord-252443-lclxrwcm	81	30	viruslike	viruslike	JJ
cord-252443-lclxrwcm	81	31	particles	particle	NNS
cord-252443-lclxrwcm	81	32	,	,	,
cord-252443-lclxrwcm	81	33	virosomes	virosomes	NN
cord-252443-lclxrwcm	81	34	and	and	CC
cord-252443-lclxrwcm	81	35	viral	viral	JJ
cord-252443-lclxrwcm	81	36	vectors	vector	NNS
cord-252443-lclxrwcm	81	37	.	.	.
cord-252443-lclxrwcm	82	1	Recombinant	recombinant	JJ
cord-252443-lclxrwcm	82	2	technology	technology	NN
cord-252443-lclxrwcm	82	3	has	have	VBZ
cord-252443-lclxrwcm	82	4	been	be	VBN
cord-252443-lclxrwcm	82	5	used	use	VBN
cord-252443-lclxrwcm	82	6	to	to	TO
cord-252443-lclxrwcm	82	7	generate	generate	VB
cord-252443-lclxrwcm	82	8	influenza	influenza	NN
cord-252443-lclxrwcm	82	9	proteins	protein	NNS
cord-252443-lclxrwcm	82	10	in	in	IN
cord-252443-lclxrwcm	82	11	insect	insect	NN
cord-252443-lclxrwcm	82	12	cells	cell	NNS
cord-252443-lclxrwcm	82	13	,	,	,
cord-252443-lclxrwcm	82	14	bacteria	bacteria	NNS
cord-252443-lclxrwcm	82	15	and	and	CC
cord-252443-lclxrwcm	82	16	plants	plant	NNS
cord-252443-lclxrwcm	82	17	(	(	-LRB-
cord-252443-lclxrwcm	82	18	63	63	CD
cord-252443-lclxrwcm	82	19	)	)	-RRB-
cord-252443-lclxrwcm	82	20	(	(	-LRB-
cord-252443-lclxrwcm	82	21	64	64	CD
cord-252443-lclxrwcm	82	22	)	)	-RRB-
cord-252443-lclxrwcm	82	23	(	(	-LRB-
cord-252443-lclxrwcm	82	24	65	65	CD
cord-252443-lclxrwcm	82	25	)	)	-RRB-
cord-252443-lclxrwcm	82	26	;	;	:
cord-252443-lclxrwcm	82	27	and	and	CC
cord-252443-lclxrwcm	82	28	although	although	IN
cord-252443-lclxrwcm	82	29	much	much	JJ
cord-252443-lclxrwcm	82	30	antigen	antigen	NN
cord-252443-lclxrwcm	82	31	can	can	MD
cord-252443-lclxrwcm	82	32	be	be	VB
cord-252443-lclxrwcm	82	33	pro	pro	JJ
cord-252443-lclxrwcm	82	34	-	-	JJ
cord-252443-lclxrwcm	82	35	duced	duced	JJ
cord-252443-lclxrwcm	82	36	,	,	,
cord-252443-lclxrwcm	82	37	these	these	DT
cord-252443-lclxrwcm	82	38	proteins	protein	NNS
cord-252443-lclxrwcm	82	39	are	be	VBP
cord-252443-lclxrwcm	82	40	generally	generally	RB
cord-252443-lclxrwcm	82	41	poorly	poorly	RB
cord-252443-lclxrwcm	82	42	immunogenic	immunogenic	JJ
cord-252443-lclxrwcm	82	43	and	and	CC
cord-252443-lclxrwcm	82	44	require	require	VB
cord-252443-lclxrwcm	82	45	complex	complex	JJ
cord-252443-lclxrwcm	82	46	immunization	immunization	NN
cord-252443-lclxrwcm	82	47	regimes	regime	NNS
cord-252443-lclxrwcm	82	48	and/or	and/or	CC
cord-252443-lclxrwcm	82	49	the	the	DT
cord-252443-lclxrwcm	82	50	inclusion	inclusion	NN
cord-252443-lclxrwcm	82	51	of	of	IN
cord-252443-lclxrwcm	82	52	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	82	53	to	to	TO
cord-252443-lclxrwcm	82	54	induce	induce	VB
cord-252443-lclxrwcm	82	55	efficacious	efficacious	JJ
cord-252443-lclxrwcm	82	56	humoral	humoral	JJ
cord-252443-lclxrwcm	82	57	immunity	immunity	NN
cord-252443-lclxrwcm	82	58	(	(	-LRB-
cord-252443-lclxrwcm	82	59	66	66	CD
cord-252443-lclxrwcm	82	60	)	)	-RRB-
cord-252443-lclxrwcm	82	61	.	.	.
cord-252443-lclxrwcm	83	1	For	for	IN
cord-252443-lclxrwcm	83	2	cellular	cellular	JJ
cord-252443-lclxrwcm	83	3	immune	immune	JJ
cord-252443-lclxrwcm	83	4	responses	response	NNS
cord-252443-lclxrwcm	83	5	,	,	,
cord-252443-lclxrwcm	83	6	antigenic	antigenic	JJ
cord-252443-lclxrwcm	83	7	mapping	mapping	NN
cord-252443-lclxrwcm	83	8	of	of	IN
cord-252443-lclxrwcm	83	9	T	t	NN
cord-252443-lclxrwcm	83	10	-	-	HYPH
cord-252443-lclxrwcm	83	11	cell	cell	NN
cord-252443-lclxrwcm	83	12	epitopes	epitope	NNS
cord-252443-lclxrwcm	83	13	followed	follow	VBN
cord-252443-lclxrwcm	83	14	with	with	IN
cord-252443-lclxrwcm	83	15	antigen	antigen	NN
cord-252443-lclxrwcm	83	16	string	string	NN
cord-252443-lclxrwcm	83	17	delivery	delivery	NN
cord-252443-lclxrwcm	83	18	(	(	-LRB-
cord-252443-lclxrwcm	83	19	in	in	IN
cord-252443-lclxrwcm	83	20	the	the	DT
cord-252443-lclxrwcm	83	21	form	form	NN
cord-252443-lclxrwcm	83	22	of	of	IN
cord-252443-lclxrwcm	83	23	peptides	peptide	NNS
cord-252443-lclxrwcm	83	24	)	)	-RRB-
cord-252443-lclxrwcm	83	25	is	be	VBZ
cord-252443-lclxrwcm	83	26	actively	actively	RB
cord-252443-lclxrwcm	83	27	being	be	VBG
cord-252443-lclxrwcm	83	28	investigated	investigate	VBN
cord-252443-lclxrwcm	83	29	.	.	.
cord-252443-lclxrwcm	84	1	Unfortunately	unfortunately	RB
cord-252443-lclxrwcm	84	2	,	,	,
cord-252443-lclxrwcm	84	3	peptides	peptide	NNS
cord-252443-lclxrwcm	84	4	are	be	VBP
cord-252443-lclxrwcm	84	5	generally	generally	RB
cord-252443-lclxrwcm	84	6	poorly	poorly	RB
cord-252443-lclxrwcm	84	7	immunogenic	immunogenic	JJ
cord-252443-lclxrwcm	84	8	,	,	,
cord-252443-lclxrwcm	84	9	and	and	CC
cord-252443-lclxrwcm	84	10	repeated	repeat	VBD
cord-252443-lclxrwcm	84	11	administration	administration	NN
cord-252443-lclxrwcm	84	12	to	to	TO
cord-252443-lclxrwcm	84	13	augment	augment	VB
cord-252443-lclxrwcm	84	14	adaptive	adaptive	JJ
cord-252443-lclxrwcm	84	15	immune	immune	JJ
cord-252443-lclxrwcm	84	16	responses	response	NNS
cord-252443-lclxrwcm	84	17	can	can	MD
cord-252443-lclxrwcm	84	18	induce	induce	VB
cord-252443-lclxrwcm	84	19	tolerance	tolerance	NN
cord-252443-lclxrwcm	84	20	rather	rather	RB
cord-252443-lclxrwcm	84	21	that	that	IN
cord-252443-lclxrwcm	84	22	immunogencity	immunogencity	NN
cord-252443-lclxrwcm	84	23	(	(	-LRB-
cord-252443-lclxrwcm	84	24	67	67	CD
cord-252443-lclxrwcm	84	25	)	)	-RRB-
cord-252443-lclxrwcm	84	26	.	.	.
cord-252443-lclxrwcm	85	1	Immunization	immunization	NN
cord-252443-lclxrwcm	85	2	with	with	IN
cord-252443-lclxrwcm	85	3	DNA	dna	NN
cord-252443-lclxrwcm	85	4	,	,	,
cord-252443-lclxrwcm	85	5	encoding	encode	VBG
cord-252443-lclxrwcm	85	6	influenza	influenza	NN
cord-252443-lclxrwcm	85	7	proteins	protein	NNS
cord-252443-lclxrwcm	85	8	,	,	,
cord-252443-lclxrwcm	85	9	has	have	VBZ
cord-252443-lclxrwcm	85	10	been	be	VBN
cord-252443-lclxrwcm	85	11	studied	study	VBN
cord-252443-lclxrwcm	85	12	for	for	IN
cord-252443-lclxrwcm	85	13	many	many	JJ
cord-252443-lclxrwcm	85	14	years	year	NNS
cord-252443-lclxrwcm	85	15	as	as	IN
cord-252443-lclxrwcm	85	16	an	an	DT
cord-252443-lclxrwcm	85	17	alternate	alternate	JJ
cord-252443-lclxrwcm	85	18	vaccination	vaccination	NN
cord-252443-lclxrwcm	85	19	strategy	strategy	NN
cord-252443-lclxrwcm	85	20	but	but	CC
cord-252443-lclxrwcm	85	21	clinical	clinical	JJ
cord-252443-lclxrwcm	85	22	trials	trial	NNS
cord-252443-lclxrwcm	85	23	have	have	VBP
cord-252443-lclxrwcm	85	24	met	meet	VBN
cord-252443-lclxrwcm	85	25	with	with	IN
cord-252443-lclxrwcm	85	26	limited	limited	JJ
cord-252443-lclxrwcm	85	27	success	success	NN
cord-252443-lclxrwcm	85	28	(	(	-LRB-
cord-252443-lclxrwcm	85	29	68	68	CD
cord-252443-lclxrwcm	85	30	,	,	,
cord-252443-lclxrwcm	85	31	69	69	CD
cord-252443-lclxrwcm	85	32	)	)	-RRB-
cord-252443-lclxrwcm	85	33	.	.	.
cord-252443-lclxrwcm	86	1	DNA	dna	NN
cord-252443-lclxrwcm	86	2	vaccines	vaccine	NNS
cord-252443-lclxrwcm	86	3	do	do	VBP
cord-252443-lclxrwcm	86	4	not	not	RB
cord-252443-lclxrwcm	86	5	boost	boost	VB
cord-252443-lclxrwcm	86	6	preexisting	preexist	VBG
cord-252443-lclxrwcm	86	7	immunity	immunity	NN
cord-252443-lclxrwcm	86	8	(	(	-LRB-
cord-252443-lclxrwcm	86	9	the	the	DT
cord-252443-lclxrwcm	86	10	scenario	scenario	NN
cord-252443-lclxrwcm	86	11	for	for	IN
cord-252443-lclxrwcm	86	12	the	the	DT
cord-252443-lclxrwcm	86	13	adult	adult	NN
cord-252443-lclxrwcm	86	14	human	human	JJ
cord-252443-lclxrwcm	86	15	population	population	NN
cord-252443-lclxrwcm	86	16	)	)	-RRB-
cord-252443-lclxrwcm	86	17	and	and	CC
cord-252443-lclxrwcm	86	18	are	be	VBP
cord-252443-lclxrwcm	86	19	generally	generally	RB
cord-252443-lclxrwcm	86	20	only	only	RB
cord-252443-lclxrwcm	86	21	weakly	weakly	RB
cord-252443-lclxrwcm	86	22	immunogenic	immunogenic	JJ
cord-252443-lclxrwcm	86	23	in	in	IN
cord-252443-lclxrwcm	86	24	humans	human	NNS
cord-252443-lclxrwcm	86	25	(	(	-LRB-
cord-252443-lclxrwcm	86	26	70	70	CD
cord-252443-lclxrwcm	86	27	)	)	-RRB-
cord-252443-lclxrwcm	86	28	.	.	.
cord-252443-lclxrwcm	87	1	Self	self	NN
cord-252443-lclxrwcm	87	2	-	-	HYPH
cord-252443-lclxrwcm	87	3	assembled	assemble	VBN
cord-252443-lclxrwcm	87	4	viral	viral	JJ
cord-252443-lclxrwcm	87	5	capsid	capsid	NN
cord-252443-lclxrwcm	87	6	proteins	protein	NNS
cord-252443-lclxrwcm	87	7	,	,	,
cord-252443-lclxrwcm	87	8	viruslike	viruslike	JJ
cord-252443-lclxrwcm	87	9	particles	particle	NNS
cord-252443-lclxrwcm	87	10	(	(	-LRB-
cord-252443-lclxrwcm	87	11	VLPs	VLPs	NNP
cord-252443-lclxrwcm	87	12	)	)	-RRB-
cord-252443-lclxrwcm	87	13	,	,	,
cord-252443-lclxrwcm	87	14	have	have	VBP
cord-252443-lclxrwcm	87	15	been	be	VBN
cord-252443-lclxrwcm	87	16	produced	produce	VBN
cord-252443-lclxrwcm	87	17	from	from	IN
cord-252443-lclxrwcm	87	18	a	a	DT
cord-252443-lclxrwcm	87	19	number	number	NN
cord-252443-lclxrwcm	87	20	of	of	IN
cord-252443-lclxrwcm	87	21	viruses	virus	NNS
cord-252443-lclxrwcm	87	22	.	.	.
cord-252443-lclxrwcm	88	1	A	a	DT
cord-252443-lclxrwcm	88	2	key	key	JJ
cord-252443-lclxrwcm	88	3	restriction	restriction	NN
cord-252443-lclxrwcm	88	4	to	to	IN
cord-252443-lclxrwcm	88	5	certain	certain	JJ
cord-252443-lclxrwcm	88	6	VLP	VLP	NNP
cord-252443-lclxrwcm	88	7	platforms	platform	NNS
cord-252443-lclxrwcm	88	8	is	be	VBZ
cord-252443-lclxrwcm	88	9	the	the	DT
cord-252443-lclxrwcm	88	10	small	small	JJ
cord-252443-lclxrwcm	88	11	size	size	NN
cord-252443-lclxrwcm	88	12	of	of	IN
cord-252443-lclxrwcm	88	13	foreign	foreign	JJ
cord-252443-lclxrwcm	88	14	epitopes	epitope	NNS
cord-252443-lclxrwcm	88	15	that	that	WDT
cord-252443-lclxrwcm	88	16	can	can	MD
cord-252443-lclxrwcm	88	17	be	be	VB
cord-252443-lclxrwcm	88	18	accommodated	accommodate	VBN
cord-252443-lclxrwcm	88	19	(	(	-LRB-
cord-252443-lclxrwcm	88	20	for	for	IN
cord-252443-lclxrwcm	88	21	example	example	NN
cord-252443-lclxrwcm	88	22	,	,	,
cord-252443-lclxrwcm	88	23	HA	HA	NNP
cord-252443-lclxrwcm	88	24	is	be	VBZ
cord-252443-lclxrwcm	88	25	a	a	DT
cord-252443-lclxrwcm	88	26	relatively	relatively	RB
cord-252443-lclxrwcm	88	27	big	big	JJ
cord-252443-lclxrwcm	88	28	protein	protein	NN
cord-252443-lclxrwcm	88	29	)	)	-RRB-
cord-252443-lclxrwcm	88	30	(	(	-LRB-
cord-252443-lclxrwcm	88	31	71	71	CD
cord-252443-lclxrwcm	88	32	)	)	-RRB-
cord-252443-lclxrwcm	88	33	.	.	.
cord-252443-lclxrwcm	89	1	For	for	IN
cord-252443-lclxrwcm	89	2	the	the	DT
cord-252443-lclxrwcm	89	3	generation	generation	NN
cord-252443-lclxrwcm	89	4	of	of	IN
cord-252443-lclxrwcm	89	5	VLPs	vlp	NNS
cord-252443-lclxrwcm	89	6	appropriate	appropriate	JJ
cord-252443-lclxrwcm	89	7	protein	protein	NN
cord-252443-lclxrwcm	89	8	glycosylation	glycosylation	NN
cord-252443-lclxrwcm	89	9	,	,	,
cord-252443-lclxrwcm	89	10	correct	correct	JJ
cord-252443-lclxrwcm	89	11	assembly	assembly	NN
cord-252443-lclxrwcm	89	12	and	and	CC
cord-252443-lclxrwcm	89	13	ease	ease	NN
cord-252443-lclxrwcm	89	14	of	of	IN
cord-252443-lclxrwcm	89	15	purification	purification	NN
cord-252443-lclxrwcm	89	16	need	need	VBP
cord-252443-lclxrwcm	89	17	to	to	TO
cord-252443-lclxrwcm	89	18	be	be	VB
cord-252443-lclxrwcm	89	19	considered	consider	VBN
cord-252443-lclxrwcm	89	20	.	.	.
cord-252443-lclxrwcm	90	1	These	these	DT
cord-252443-lclxrwcm	90	2	concerns	concern	NNS
cord-252443-lclxrwcm	90	3	may	may	MD
cord-252443-lclxrwcm	90	4	dictate	dictate	VB
cord-252443-lclxrwcm	90	5	the	the	DT
cord-252443-lclxrwcm	90	6	use	use	NN
cord-252443-lclxrwcm	90	7	of	of	IN
cord-252443-lclxrwcm	90	8	mammalian	mammalian	JJ
cord-252443-lclxrwcm	90	9	cell	cell	NN
cord-252443-lclxrwcm	90	10	culture	culture	NN
cord-252443-lclxrwcm	90	11	systems	system	NNS
cord-252443-lclxrwcm	90	12	,	,	,
cord-252443-lclxrwcm	90	13	which	which	WDT
cord-252443-lclxrwcm	90	14	is	be	VBZ
cord-252443-lclxrwcm	90	15	a	a	DT
cord-252443-lclxrwcm	90	16	less	less	RBR
cord-252443-lclxrwcm	90	17	controllable	controllable	JJ
cord-252443-lclxrwcm	90	18	and	and	CC
cord-252443-lclxrwcm	90	19	a	a	DT
cord-252443-lclxrwcm	90	20	more	more	RBR
cord-252443-lclxrwcm	90	21	costly	costly	JJ
cord-252443-lclxrwcm	90	22	system	system	NN
cord-252443-lclxrwcm	90	23	(	(	-LRB-
cord-252443-lclxrwcm	90	24	71	71	CD
cord-252443-lclxrwcm	90	25	)	)	-RRB-
cord-252443-lclxrwcm	90	26	.	.	.
cord-252443-lclxrwcm	91	1	Although	although	IN
cord-252443-lclxrwcm	91	2	similar	similar	JJ
cord-252443-lclxrwcm	91	3	to	to	IN
cord-252443-lclxrwcm	91	4	VLPs	vlp	NNS
cord-252443-lclxrwcm	91	5	in	in	IN
cord-252443-lclxrwcm	91	6	many	many	JJ
cord-252443-lclxrwcm	91	7	respects	respect	NNS
cord-252443-lclxrwcm	91	8	,	,	,
cord-252443-lclxrwcm	91	9	virosomes	virosome	NNS
cord-252443-lclxrwcm	91	10	,	,	,
cord-252443-lclxrwcm	91	11	by	by	IN
cord-252443-lclxrwcm	91	12	contrast	contrast	NN
cord-252443-lclxrwcm	91	13	,	,	,
cord-252443-lclxrwcm	91	14	are	be	VBP
cord-252443-lclxrwcm	91	15	essentially	essentially	RB
cord-252443-lclxrwcm	91	16	assembled	assemble	VBN
cord-252443-lclxrwcm	91	17	in	in	IN
cord-252443-lclxrwcm	91	18	vitro	vitro	FW
cord-252443-lclxrwcm	91	19	.	.	.
cord-252443-lclxrwcm	92	1	There	there	EX
cord-252443-lclxrwcm	92	2	are	be	VBP
cord-252443-lclxrwcm	92	3	a	a	DT
cord-252443-lclxrwcm	92	4	limited	limited	JJ
cord-252443-lclxrwcm	92	5	number	number	NN
cord-252443-lclxrwcm	92	6	of	of	IN
cord-252443-lclxrwcm	92	7	virosomal	virosomal	NN
cord-252443-lclxrwcm	92	8	-	-	HYPH
cord-252443-lclxrwcm	92	9	adjuvanted	adjuvante	VBN
cord-252443-lclxrwcm	92	10	-	-	HYPH
cord-252443-lclxrwcm	92	11	subunit	subunit	NN
cord-252443-lclxrwcm	92	12	influenza	influenza	NN
cord-252443-lclxrwcm	92	13	vaccines	vaccine	NNS
cord-252443-lclxrwcm	92	14	currently	currently	RB
cord-252443-lclxrwcm	92	15	licensed	license	VBN
cord-252443-lclxrwcm	92	16	;	;	:
cord-252443-lclxrwcm	92	17	the	the	DT
cord-252443-lclxrwcm	92	18	generation	generation	NN
cord-252443-lclxrwcm	92	19	of	of	IN
cord-252443-lclxrwcm	92	20	these	these	DT
cord-252443-lclxrwcm	92	21	vaccines	vaccine	NNS
cord-252443-lclxrwcm	92	22	requires	require	VBZ
cord-252443-lclxrwcm	92	23	good	good	JJ
cord-252443-lclxrwcm	92	24	manufacturing	manufacturing	NN
cord-252443-lclxrwcm	92	25	practice	practice	NN
cord-252443-lclxrwcm	92	26	(	(	-LRB-
cord-252443-lclxrwcm	92	27	GMP)-grade	GMP)-grade	VBN
cord-252443-lclxrwcm	92	28	influenza	influenza	NN
cord-252443-lclxrwcm	92	29	virus	virus	NN
cord-252443-lclxrwcm	92	30	and	and	CC
cord-252443-lclxrwcm	92	31	,	,	,
cord-252443-lclxrwcm	92	32	as	as	IN
cord-252443-lclxrwcm	92	33	such	such	JJ
cord-252443-lclxrwcm	92	34	,	,	,
cord-252443-lclxrwcm	92	35	these	these	DT
cord-252443-lclxrwcm	92	36	vaccines	vaccine	NNS
cord-252443-lclxrwcm	92	37	face	face	VBP
cord-252443-lclxrwcm	92	38	similar	similar	JJ
cord-252443-lclxrwcm	92	39	obstacles	obstacle	NNS
cord-252443-lclxrwcm	92	40	as	as	IN
cord-252443-lclxrwcm	92	41	the	the	DT
cord-252443-lclxrwcm	92	42	production	production	NN
cord-252443-lclxrwcm	92	43	of	of	IN
cord-252443-lclxrwcm	92	44	TIV	TIV	NNP
cord-252443-lclxrwcm	92	45	(	(	-LRB-
cord-252443-lclxrwcm	92	46	72	72	CD
cord-252443-lclxrwcm	92	47	,	,	,
cord-252443-lclxrwcm	92	48	73	73	CD
cord-252443-lclxrwcm	92	49	)	)	-RRB-
cord-252443-lclxrwcm	92	50	.	.	.
cord-252443-lclxrwcm	93	1	Vectored	vectore	VBN
cord-252443-lclxrwcm	93	2	vaccines	vaccine	NNS
cord-252443-lclxrwcm	93	3	,	,	,
cord-252443-lclxrwcm	93	4	such	such	JJ
cord-252443-lclxrwcm	93	5	as	as	IN
cord-252443-lclxrwcm	93	6	recombinant	recombinant	JJ
cord-252443-lclxrwcm	93	7	live	live	RB
cord-252443-lclxrwcm	93	8	-	-	HYPH
cord-252443-lclxrwcm	93	9	attenuated	attenuate	VBN
cord-252443-lclxrwcm	93	10	or	or	CC
cord-252443-lclxrwcm	93	11	replicationdeficient	replicationdeficient	NN
cord-252443-lclxrwcm	93	12	viruses	virus	NNS
cord-252443-lclxrwcm	93	13	,	,	,
cord-252443-lclxrwcm	93	14	are	be	VBP
cord-252443-lclxrwcm	93	15	currently	currently	RB
cord-252443-lclxrwcm	93	16	being	be	VBG
cord-252443-lclxrwcm	93	17	developed	develop	VBN
cord-252443-lclxrwcm	93	18	for	for	IN
cord-252443-lclxrwcm	93	19	vaccine	vaccine	NN
cord-252443-lclxrwcm	93	20	delivery	delivery	NN
cord-252443-lclxrwcm	93	21	and	and	CC
cord-252443-lclxrwcm	93	22	offer	offer	VB
cord-252443-lclxrwcm	93	23	a	a	DT
cord-252443-lclxrwcm	93	24	number	number	NN
cord-252443-lclxrwcm	93	25	of	of	IN
cord-252443-lclxrwcm	93	26	advantages	advantage	NNS
cord-252443-lclxrwcm	93	27	over	over	IN
cord-252443-lclxrwcm	93	28	other	other	JJ
cord-252443-lclxrwcm	93	29	emerging	emerge	VBG
cord-252443-lclxrwcm	93	30	technologies	technology	NNS
cord-252443-lclxrwcm	93	31	.	.	.
cord-252443-lclxrwcm	94	1	Viral	viral	JJ
cord-252443-lclxrwcm	94	2	vectored	vectore	VBN
cord-252443-lclxrwcm	94	3	vaccines	vaccine	NNS
cord-252443-lclxrwcm	94	4	are	be	VBP
cord-252443-lclxrwcm	94	5	particularly	particularly	RB
cord-252443-lclxrwcm	94	6	good	good	JJ
cord-252443-lclxrwcm	94	7	at	at	IN
cord-252443-lclxrwcm	94	8	expressing	express	VBG
cord-252443-lclxrwcm	94	9	full	full	JJ
cord-252443-lclxrwcm	94	10	-	-	HYPH
cord-252443-lclxrwcm	94	11	length	length	NN
cord-252443-lclxrwcm	94	12	protein	protein	NN
cord-252443-lclxrwcm	94	13	and	and	CC
cord-252443-lclxrwcm	94	14	generating	generate	VBG
cord-252443-lclxrwcm	94	15	conformationally	conformationally	RB
cord-252443-lclxrwcm	94	16	restricted	restrict	VBN
cord-252443-lclxrwcm	94	17	epitopes	epitope	NNS
cord-252443-lclxrwcm	94	18	,	,	,
cord-252443-lclxrwcm	94	19	thus	thus	RB
cord-252443-lclxrwcm	94	20	driving	drive	VBG
cord-252443-lclxrwcm	94	21	potent	potent	JJ
cord-252443-lclxrwcm	94	22	humoral	humoral	JJ
cord-252443-lclxrwcm	94	23	responses	response	NNS
cord-252443-lclxrwcm	94	24	following	follow	VBG
cord-252443-lclxrwcm	94	25	immunization	immunization	NN
cord-252443-lclxrwcm	94	26	(	(	-LRB-
cord-252443-lclxrwcm	94	27	74	74	CD
cord-252443-lclxrwcm	94	28	)	)	-RRB-
cord-252443-lclxrwcm	94	29	.	.	.
cord-252443-lclxrwcm	95	1	In	in	IN
cord-252443-lclxrwcm	95	2	addition	addition	NN
cord-252443-lclxrwcm	95	3	,	,	,
cord-252443-lclxrwcm	95	4	vectored	vectore	VBN
cord-252443-lclxrwcm	95	5	vaccines	vaccine	NNS
cord-252443-lclxrwcm	95	6	can	can	MD
cord-252443-lclxrwcm	95	7	induce	induce	VB
cord-252443-lclxrwcm	95	8	high	high	JJ
cord-252443-lclxrwcm	95	9	levels	level	NNS
cord-252443-lclxrwcm	95	10	of	of	IN
cord-252443-lclxrwcm	95	11	protective	protective	JJ
cord-252443-lclxrwcm	95	12	cellular	cellular	JJ
cord-252443-lclxrwcm	95	13	immunity	immunity	NN
cord-252443-lclxrwcm	95	14	(	(	-LRB-
cord-252443-lclxrwcm	95	15	75	75	CD
cord-252443-lclxrwcm	95	16	)	)	-RRB-
cord-252443-lclxrwcm	95	17	(	(	-LRB-
cord-252443-lclxrwcm	95	18	76	76	CD
cord-252443-lclxrwcm	95	19	)	)	-RRB-
cord-252443-lclxrwcm	95	20	(	(	-LRB-
cord-252443-lclxrwcm	95	21	77	77	CD
cord-252443-lclxrwcm	95	22	)	)	-RRB-
cord-252443-lclxrwcm	95	23	.	.	.
cord-252443-lclxrwcm	96	1	Thus	thus	RB
cord-252443-lclxrwcm	96	2	,	,	,
cord-252443-lclxrwcm	96	3	viral	viral	JJ
cord-252443-lclxrwcm	96	4	vectors	vector	NNS
cord-252443-lclxrwcm	96	5	efficaciously	efficaciously	RB
cord-252443-lclxrwcm	96	6	induce	induce	VBP
cord-252443-lclxrwcm	96	7	both	both	DT
cord-252443-lclxrwcm	96	8	arms	arm	NNS
cord-252443-lclxrwcm	96	9	of	of	IN
cord-252443-lclxrwcm	96	10	the	the	DT
cord-252443-lclxrwcm	96	11	adaptive	adaptive	JJ
cord-252443-lclxrwcm	96	12	immune	immune	JJ
cord-252443-lclxrwcm	96	13	system	system	NN
cord-252443-lclxrwcm	96	14	.	.	.
cord-252443-lclxrwcm	97	1	Following	follow	VBG
cord-252443-lclxrwcm	97	2	vaccination	vaccination	NN
cord-252443-lclxrwcm	97	3	with	with	IN
cord-252443-lclxrwcm	97	4	viral	viral	JJ
cord-252443-lclxrwcm	97	5	vector	vector	NN
cord-252443-lclxrwcm	97	6	vaccines	vaccine	NNS
cord-252443-lclxrwcm	97	7	,	,	,
cord-252443-lclxrwcm	97	8	virus	virus	NN
cord-252443-lclxrwcm	97	9	can	can	MD
cord-252443-lclxrwcm	97	10	infect	infect	VB
cord-252443-lclxrwcm	97	11	local	local	JJ
cord-252443-lclxrwcm	97	12	cells	cell	NNS
cord-252443-lclxrwcm	97	13	and	and	CC
cord-252443-lclxrwcm	97	14	produce	produce	VB
cord-252443-lclxrwcm	97	15	high	high	JJ
cord-252443-lclxrwcm	97	16	levels	level	NNS
cord-252443-lclxrwcm	97	17	of	of	IN
cord-252443-lclxrwcm	97	18	protein	protein	NN
cord-252443-lclxrwcm	97	19	(	(	-LRB-
cord-252443-lclxrwcm	97	20	up	up	IN
cord-252443-lclxrwcm	97	21	to	to	TO
cord-252443-lclxrwcm	97	22	100	100	CD
cord-252443-lclxrwcm	97	23	μg	μg	NN
cord-252443-lclxrwcm	97	24	following	follow	VBG
cord-252443-lclxrwcm	97	25	vaccination	vaccination	NN
cord-252443-lclxrwcm	97	26	with	with	IN
cord-252443-lclxrwcm	97	27	a	a	DT
cord-252443-lclxrwcm	97	28	modest	modest	JJ
cord-252443-lclxrwcm	97	29	amount	amount	NN
cord-252443-lclxrwcm	97	30	of	of	IN
cord-252443-lclxrwcm	97	31	viral	viral	JJ
cord-252443-lclxrwcm	97	32	vector	vector	NN
cord-252443-lclxrwcm	97	33	,	,	,
cord-252443-lclxrwcm	97	34	10	10	CD
cord-252443-lclxrwcm	97	35	10	10	CD
cord-252443-lclxrwcm	97	36	viral	viral	JJ
cord-252443-lclxrwcm	97	37	particles	particle	NNS
cord-252443-lclxrwcm	97	38	(	(	-LRB-
cord-252443-lclxrwcm	97	39	VP	VP	NNP
cord-252443-lclxrwcm	97	40	)	)	-RRB-
cord-252443-lclxrwcm	97	41	of	of	IN
cord-252443-lclxrwcm	97	42	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	97	43	or	or	CC
cord-252443-lclxrwcm	97	44	10	10	CD
cord-252443-lclxrwcm	97	45	7	7	CD
cord-252443-lclxrwcm	97	46	plaque	plaque	NN
cord-252443-lclxrwcm	97	47	-	-	HYPH
cord-252443-lclxrwcm	97	48	forming	form	VBG
cord-252443-lclxrwcm	97	49	units	unit	NNS
cord-252443-lclxrwcm	97	50	(	(	-LRB-
cord-252443-lclxrwcm	97	51	PFU	pfu	NN
cord-252443-lclxrwcm	97	52	)	)	-RRB-
cord-252443-lclxrwcm	97	53	of	of	IN
cord-252443-lclxrwcm	97	54	modified	modify	VBN
cord-252443-lclxrwcm	97	55	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	97	56	virus	virus	NN
cord-252443-lclxrwcm	97	57	Ankara	Ankara	NNP
cord-252443-lclxrwcm	97	58	)	)	-RRB-
cord-252443-lclxrwcm	97	59	(	(	-LRB-
cord-252443-lclxrwcm	97	60	78	78	CD
cord-252443-lclxrwcm	97	61	)	)	-RRB-
cord-252443-lclxrwcm	97	62	.	.	.
cord-252443-lclxrwcm	98	1	Antigen	Antigen	NNP
cord-252443-lclxrwcm	98	2	has	have	VBZ
cord-252443-lclxrwcm	98	3	been	be	VBN
cord-252443-lclxrwcm	98	4	detected	detect	VBN
cord-252443-lclxrwcm	98	5	at	at	IN
cord-252443-lclxrwcm	98	6	the	the	DT
cord-252443-lclxrwcm	98	7	immunization	immunization	NN
cord-252443-lclxrwcm	98	8	site	site	NN
cord-252443-lclxrwcm	98	9	up	up	IN
cord-252443-lclxrwcm	98	10	to	to	TO
cord-252443-lclxrwcm	98	11	6	6	CD
cord-252443-lclxrwcm	98	12	months	month	NNS
cord-252443-lclxrwcm	98	13	after	after	IN
cord-252443-lclxrwcm	98	14	viral	viral	JJ
cord-252443-lclxrwcm	98	15	vectored	vectore	VBN
cord-252443-lclxrwcm	98	16	vaccination	vaccination	NN
cord-252443-lclxrwcm	98	17	(	(	-LRB-
cord-252443-lclxrwcm	98	18	79	79	CD
cord-252443-lclxrwcm	98	19	,	,	,
cord-252443-lclxrwcm	98	20	80	80	CD
cord-252443-lclxrwcm	98	21	)	)	-RRB-
cord-252443-lclxrwcm	98	22	,	,	,
cord-252443-lclxrwcm	98	23	which	which	WDT
cord-252443-lclxrwcm	98	24	is	be	VBZ
cord-252443-lclxrwcm	98	25	in	in	IN
cord-252443-lclxrwcm	98	26	contrast	contrast	NN
cord-252443-lclxrwcm	98	27	to	to	IN
cord-252443-lclxrwcm	98	28	the	the	DT
cord-252443-lclxrwcm	98	29	transient	transient	JJ
cord-252443-lclxrwcm	98	30	antigen	antigen	NN
cord-252443-lclxrwcm	98	31	depots	depot	NNS
cord-252443-lclxrwcm	98	32	following	follow	VBG
cord-252443-lclxrwcm	98	33	protein	protein	NN
cord-252443-lclxrwcm	98	34	vaccination	vaccination	NN
cord-252443-lclxrwcm	98	35	,	,	,
cord-252443-lclxrwcm	98	36	even	even	RB
cord-252443-lclxrwcm	98	37	when	when	WRB
cord-252443-lclxrwcm	98	38	coadministered	coadministere	VBN
cord-252443-lclxrwcm	98	39	with	with	IN
cord-252443-lclxrwcm	98	40	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	98	41	(	(	-LRB-
cord-252443-lclxrwcm	98	42	81	81	CD
cord-252443-lclxrwcm	98	43	)	)	-RRB-
cord-252443-lclxrwcm	98	44	.	.	.
cord-252443-lclxrwcm	99	1	The	the	DT
cord-252443-lclxrwcm	99	2	increased	increase	VBN
cord-252443-lclxrwcm	99	3	presence	presence	NN
cord-252443-lclxrwcm	99	4	of	of	IN
cord-252443-lclxrwcm	99	5	antigen	antigen	NNP
cord-252443-lclxrwcm	99	6	may	may	MD
cord-252443-lclxrwcm	99	7	enhance	enhance	VB
cord-252443-lclxrwcm	99	8	the	the	DT
cord-252443-lclxrwcm	99	9	survival	survival	NN
cord-252443-lclxrwcm	99	10	of	of	IN
cord-252443-lclxrwcm	99	11	certain	certain	JJ
cord-252443-lclxrwcm	99	12	memory	memory	NN
cord-252443-lclxrwcm	99	13	T	t	NN
cord-252443-lclxrwcm	99	14	cells	cell	NNS
cord-252443-lclxrwcm	99	15	and	and	CC
cord-252443-lclxrwcm	99	16	augment	augment	VB
cord-252443-lclxrwcm	99	17	high	high	JJ
cord-252443-lclxrwcm	99	18	-	-	HYPH
cord-252443-lclxrwcm	99	19	affinity	affinity	NN
cord-252443-lclxrwcm	99	20	antibody	antibody	NN
cord-252443-lclxrwcm	99	21	selection	selection	NN
cord-252443-lclxrwcm	99	22	(	(	-LRB-
cord-252443-lclxrwcm	99	23	82	82	CD
cord-252443-lclxrwcm	99	24	,	,	,
cord-252443-lclxrwcm	99	25	83	83	CD
cord-252443-lclxrwcm	99	26	)	)	-RRB-
cord-252443-lclxrwcm	99	27	.	.	.
cord-252443-lclxrwcm	100	1	Viral	viral	JJ
cord-252443-lclxrwcm	100	2	infection	infection	NN
cord-252443-lclxrwcm	100	3	results	result	VBZ
cord-252443-lclxrwcm	100	4	in	in	IN
cord-252443-lclxrwcm	100	5	both	both	DT
cord-252443-lclxrwcm	100	6	apoptosis	apoptosis	NN
cord-252443-lclxrwcm	100	7	and	and	CC
cord-252443-lclxrwcm	100	8	necrosis	necrosis	NN
cord-252443-lclxrwcm	100	9	of	of	IN
cord-252443-lclxrwcm	100	10	localized	localized	JJ
cord-252443-lclxrwcm	100	11	tissue	tissue	NN
cord-252443-lclxrwcm	100	12	,	,	,
cord-252443-lclxrwcm	100	13	facilitating	facilitate	VBG
cord-252443-lclxrwcm	100	14	the	the	DT
cord-252443-lclxrwcm	100	15	release	release	NN
cord-252443-lclxrwcm	100	16	of	of	IN
cord-252443-lclxrwcm	100	17	antigen	antigen	NN
cord-252443-lclxrwcm	100	18	,	,	,
cord-252443-lclxrwcm	100	19	which	which	WDT
cord-252443-lclxrwcm	100	20	is	be	VBZ
cord-252443-lclxrwcm	100	21	subsequently	subsequently	RB
cord-252443-lclxrwcm	100	22	available	available	JJ
cord-252443-lclxrwcm	100	23	to	to	TO
cord-252443-lclxrwcm	100	24	drive	drive	VB
cord-252443-lclxrwcm	100	25	cellular	cellular	JJ
cord-252443-lclxrwcm	100	26	and	and	CC
cord-252443-lclxrwcm	100	27	humoral	humoral	JJ
cord-252443-lclxrwcm	100	28	immunity	immunity	NN
cord-252443-lclxrwcm	100	29	(	(	-LRB-
cord-252443-lclxrwcm	100	30	84	84	CD
cord-252443-lclxrwcm	100	31	,	,	,
cord-252443-lclxrwcm	100	32	85	85	CD
cord-252443-lclxrwcm	100	33	)	)	-RRB-
cord-252443-lclxrwcm	100	34	.	.	.
cord-252443-lclxrwcm	101	1	The	the	DT
cord-252443-lclxrwcm	101	2	associated	associated	JJ
cord-252443-lclxrwcm	101	3	cell	cell	NN
cord-252443-lclxrwcm	101	4	death	death	NN
cord-252443-lclxrwcm	101	5	following	follow	VBG
cord-252443-lclxrwcm	101	6	viral	viral	JJ
cord-252443-lclxrwcm	101	7	infection	infection	NN
cord-252443-lclxrwcm	101	8	will	will	MD
cord-252443-lclxrwcm	101	9	also	also	RB
cord-252443-lclxrwcm	101	10	advantageously	advantageously	RB
cord-252443-lclxrwcm	101	11	augment	augment	VB
cord-252443-lclxrwcm	101	12	adaptive	adaptive	JJ
cord-252443-lclxrwcm	101	13	immune	immune	JJ
cord-252443-lclxrwcm	101	14	responses	response	NNS
cord-252443-lclxrwcm	101	15	,	,	,
cord-252443-lclxrwcm	101	16	circumventing	circumvent	VBG
cord-252443-lclxrwcm	101	17	the	the	DT
cord-252443-lclxrwcm	101	18	need	need	NN
cord-252443-lclxrwcm	101	19	for	for	IN
cord-252443-lclxrwcm	101	20	the	the	DT
cord-252443-lclxrwcm	101	21	inclusion	inclusion	NN
cord-252443-lclxrwcm	101	22	of	of	IN
cord-252443-lclxrwcm	101	23	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	101	24	.	.	.
cord-252443-lclxrwcm	102	1	Live	live	JJ
cord-252443-lclxrwcm	102	2	recombinant	recombinant	JJ
cord-252443-lclxrwcm	102	3	viral	viral	JJ
cord-252443-lclxrwcm	102	4	vectors	vector	NNS
cord-252443-lclxrwcm	102	5	must	must	MD
cord-252443-lclxrwcm	102	6	remain	remain	VB
cord-252443-lclxrwcm	102	7	infectious	infectious	JJ
cord-252443-lclxrwcm	102	8	to	to	TO
cord-252443-lclxrwcm	102	9	be	be	VB
cord-252443-lclxrwcm	102	10	effective	effective	JJ
cord-252443-lclxrwcm	102	11	,	,	,
cord-252443-lclxrwcm	102	12	and	and	CC
cord-252443-lclxrwcm	102	13	conventional	conventional	JJ
cord-252443-lclxrwcm	102	14	,	,	,
cord-252443-lclxrwcm	102	15	continuous	continuous	JJ
cord-252443-lclxrwcm	102	16	refrigeration	refrigeration	NN
cord-252443-lclxrwcm	102	17	is	be	VBZ
cord-252443-lclxrwcm	102	18	required	require	VBN
cord-252443-lclxrwcm	102	19	to	to	TO
cord-252443-lclxrwcm	102	20	maintain	maintain	VB
cord-252443-lclxrwcm	102	21	stability	stability	NN
cord-252443-lclxrwcm	102	22	and	and	CC
cord-252443-lclxrwcm	102	23	viability	viability	NN
cord-252443-lclxrwcm	102	24	.	.	.
cord-252443-lclxrwcm	103	1	However	however	RB
cord-252443-lclxrwcm	103	2	,	,	,
cord-252443-lclxrwcm	103	3	recent	recent	JJ
cord-252443-lclxrwcm	103	4	methodologies	methodology	NNS
cord-252443-lclxrwcm	103	5	have	have	VBP
cord-252443-lclxrwcm	103	6	allowed	allow	VBN
cord-252443-lclxrwcm	103	7	complete	complete	JJ
cord-252443-lclxrwcm	103	8	recovery	recovery	NN
cord-252443-lclxrwcm	103	9	of	of	IN
cord-252443-lclxrwcm	103	10	viral	viral	JJ
cord-252443-lclxrwcm	103	11	titer	titer	NN
cord-252443-lclxrwcm	103	12	and	and	CC
cord-252443-lclxrwcm	103	13	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	103	14	after	after	IN
cord-252443-lclxrwcm	103	15	storage	storage	NN
cord-252443-lclxrwcm	103	16	at	at	IN
cord-252443-lclxrwcm	103	17	up	up	IN
cord-252443-lclxrwcm	103	18	to	to	TO
cord-252443-lclxrwcm	103	19	45	45	CD
cord-252443-lclxrwcm	103	20	°	°	NN
cord-252443-lclxrwcm	103	21	C	c	NN
cord-252443-lclxrwcm	103	22	for	for	IN
cord-252443-lclxrwcm	103	23	6	6	CD
cord-252443-lclxrwcm	103	24	months	month	NNS
cord-252443-lclxrwcm	103	25	(	(	-LRB-
cord-252443-lclxrwcm	103	26	86	86	CD
cord-252443-lclxrwcm	103	27	)	)	-RRB-
cord-252443-lclxrwcm	103	28	.	.	.
cord-252443-lclxrwcm	104	1	In	in	IN
cord-252443-lclxrwcm	104	2	addition	addition	NN
cord-252443-lclxrwcm	104	3	,	,	,
cord-252443-lclxrwcm	104	4	viral	viral	JJ
cord-252443-lclxrwcm	104	5	vectored	vectore	VBN
cord-252443-lclxrwcm	104	6	vaccines	vaccine	NNS
cord-252443-lclxrwcm	104	7	are	be	VBP
cord-252443-lclxrwcm	104	8	relatively	relatively	RB
cord-252443-lclxrwcm	104	9	easy	easy	JJ
cord-252443-lclxrwcm	104	10	to	to	TO
cord-252443-lclxrwcm	104	11	manipulate	manipulate	VB
cord-252443-lclxrwcm	104	12	and	and	CC
cord-252443-lclxrwcm	104	13	produce	produce	VB
cord-252443-lclxrwcm	104	14	,	,	,
cord-252443-lclxrwcm	104	15	and	and	CC
cord-252443-lclxrwcm	104	16	have	have	VBP
cord-252443-lclxrwcm	104	17	well	well	RB
cord-252443-lclxrwcm	104	18	-	-	HYPH
cord-252443-lclxrwcm	104	19	established	establish	VBN
cord-252443-lclxrwcm	104	20	safety	safety	NN
cord-252443-lclxrwcm	104	21	profiles	profile	NNS
cord-252443-lclxrwcm	104	22	.	.	.
cord-252443-lclxrwcm	105	1	There	there	EX
cord-252443-lclxrwcm	105	2	are	be	VBP
cord-252443-lclxrwcm	105	3	an	an	DT
cord-252443-lclxrwcm	105	4	increasing	increase	VBG
cord-252443-lclxrwcm	105	5	number	number	NN
cord-252443-lclxrwcm	105	6	of	of	IN
cord-252443-lclxrwcm	105	7	viral	viral	NN
cord-252443-lclxrwcm	105	8	-	-	HYPH
cord-252443-lclxrwcm	105	9	based	base	VBN
cord-252443-lclxrwcm	105	10	vectors	vector	NNS
cord-252443-lclxrwcm	105	11	currently	currently	RB
cord-252443-lclxrwcm	105	12	employed	employ	VBN
cord-252443-lclxrwcm	105	13	as	as	IN
cord-252443-lclxrwcm	105	14	antigen	antigen	NN
cord-252443-lclxrwcm	105	15	delivery	delivery	NN
cord-252443-lclxrwcm	105	16	systems	system	NNS
cord-252443-lclxrwcm	105	17	,	,	,
cord-252443-lclxrwcm	105	18	including	include	VBG
cord-252443-lclxrwcm	105	19	DNA	dna	NN
cord-252443-lclxrwcm	105	20	virus	virus	NN
cord-252443-lclxrwcm	105	21	vectors	vector	NNS
cord-252443-lclxrwcm	105	22	(	(	-LRB-
cord-252443-lclxrwcm	105	23	for	for	IN
cord-252443-lclxrwcm	105	24	example	example	NN
cord-252443-lclxrwcm	105	25	,	,	,
cord-252443-lclxrwcm	105	26	poxviruses	poxvirus	NNS
cord-252443-lclxrwcm	105	27	,	,	,
cord-252443-lclxrwcm	105	28	herpesvirus	herpesvirus	NN
cord-252443-lclxrwcm	105	29	,	,	,
cord-252443-lclxrwcm	105	30	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	105	31	and	and	CC
cord-252443-lclxrwcm	105	32	baculovirus	baculovirus	NNP
cord-252443-lclxrwcm	105	33	)	)	-RRB-
cord-252443-lclxrwcm	105	34	and	and	CC
cord-252443-lclxrwcm	105	35	RNA	RNA	NNP
cord-252443-lclxrwcm	105	36	virus	virus	NN
cord-252443-lclxrwcm	105	37	vectors	vector	NNS
cord-252443-lclxrwcm	105	38	(	(	-LRB-
cord-252443-lclxrwcm	105	39	for	for	IN
cord-252443-lclxrwcm	105	40	example	example	NN
cord-252443-lclxrwcm	105	41	,	,	,
cord-252443-lclxrwcm	105	42	paramyxovirus	paramyxovirus	NNP
cord-252443-lclxrwcm	105	43	,	,	,
cord-252443-lclxrwcm	105	44	rhabdovirus	rhabdovirus	NNP
cord-252443-lclxrwcm	105	45	,	,	,
cord-252443-lclxrwcm	105	46	bunyavirus	bunyavirus	NNP
cord-252443-lclxrwcm	105	47	,	,	,
cord-252443-lclxrwcm	105	48	alphavirus	alphavirus	NNP
cord-252443-lclxrwcm	105	49	,	,	,
cord-252443-lclxrwcm	105	50	coronavirus	coronavirus	NN
cord-252443-lclxrwcm	105	51	,	,	,
cord-252443-lclxrwcm	105	52	retrovirus	retrovirus	NN
cord-252443-lclxrwcm	105	53	and	and	CC
cord-252443-lclxrwcm	105	54	flavivirus	flavivirus	NNP
cord-252443-lclxrwcm	105	55	)	)	-RRB-
cord-252443-lclxrwcm	105	56	(	(	-LRB-
cord-252443-lclxrwcm	105	57	87	87	CD
cord-252443-lclxrwcm	105	58	)	)	-RRB-
cord-252443-lclxrwcm	105	59	.	.	.
cord-252443-lclxrwcm	106	1	However	however	RB
cord-252443-lclxrwcm	106	2	,	,	,
cord-252443-lclxrwcm	106	3	the	the	DT
cord-252443-lclxrwcm	106	4	majority	majority	NN
cord-252443-lclxrwcm	106	5	of	of	IN
cord-252443-lclxrwcm	106	6	human	human	JJ
cord-252443-lclxrwcm	106	7	clinical	clinical	JJ
cord-252443-lclxrwcm	106	8	trials	trial	NNS
cord-252443-lclxrwcm	106	9	assessing	assess	VBG
cord-252443-lclxrwcm	106	10	viral	viral	JJ
cord-252443-lclxrwcm	106	11	vectored	vectore	VBN
cord-252443-lclxrwcm	106	12	influenza	influenza	NN
cord-252443-lclxrwcm	106	13	vaccines	vaccine	NNS
cord-252443-lclxrwcm	106	14	use	use	VBP
cord-252443-lclxrwcm	106	15	poxviral	poxviral	JJ
cord-252443-lclxrwcm	106	16	and	and	CC
cord-252443-lclxrwcm	106	17	adenoviral	adenoviral	JJ
cord-252443-lclxrwcm	106	18	technologies	technology	NNS
cord-252443-lclxrwcm	106	19	,	,	,
cord-252443-lclxrwcm	106	20	and	and	CC
cord-252443-lclxrwcm	106	21	these	these	DT
cord-252443-lclxrwcm	106	22	vectors	vector	NNS
cord-252443-lclxrwcm	106	23	are	be	VBP
cord-252443-lclxrwcm	106	24	considered	consider	VBN
cord-252443-lclxrwcm	106	25	lead	lead	JJ
cord-252443-lclxrwcm	106	26	candidates	candidate	NNS
cord-252443-lclxrwcm	106	27	for	for	IN
cord-252443-lclxrwcm	106	28	the	the	DT
cord-252443-lclxrwcm	106	29	immunogenic	immunogenic	JJ
cord-252443-lclxrwcm	106	30	delivery	delivery	NN
cord-252443-lclxrwcm	106	31	of	of	IN
cord-252443-lclxrwcm	106	32	antigens	antigen	NNS
cord-252443-lclxrwcm	106	33	(	(	-LRB-
cord-252443-lclxrwcm	106	34	77	77	CD
cord-252443-lclxrwcm	106	35	)	)	-RRB-
cord-252443-lclxrwcm	106	36	.	.	.
cord-252443-lclxrwcm	107	1	Adenoviruses	adenovirus	NNS
cord-252443-lclxrwcm	107	2	(	(	-LRB-
cord-252443-lclxrwcm	107	3	Ads	ad	NNS
cord-252443-lclxrwcm	107	4	)	)	-RRB-
cord-252443-lclxrwcm	107	5	are	be	VBP
cord-252443-lclxrwcm	107	6	nonenveloped	nonenvelope	VBN
cord-252443-lclxrwcm	107	7	DNA	dna	NN
cord-252443-lclxrwcm	107	8	viruses	virus	NNS
cord-252443-lclxrwcm	107	9	originally	originally	RB
cord-252443-lclxrwcm	107	10	identified	identify	VBN
cord-252443-lclxrwcm	107	11	as	as	IN
cord-252443-lclxrwcm	107	12	infectious	infectious	JJ
cord-252443-lclxrwcm	107	13	agents	agent	NNS
cord-252443-lclxrwcm	107	14	responsible	responsible	JJ
cord-252443-lclxrwcm	107	15	for	for	IN
cord-252443-lclxrwcm	107	16	certain	certain	JJ
cord-252443-lclxrwcm	107	17	acute	acute	JJ
cord-252443-lclxrwcm	107	18	respiratory	respiratory	JJ
cord-252443-lclxrwcm	107	19	infections	infection	NNS
cord-252443-lclxrwcm	107	20	.	.	.
cord-252443-lclxrwcm	108	1	Ad	ad	NN
cord-252443-lclxrwcm	108	2	infection	infection	NN
cord-252443-lclxrwcm	108	3	usually	usually	RB
cord-252443-lclxrwcm	108	4	manifests	manifest	VBZ
cord-252443-lclxrwcm	108	5	as	as	IN
cord-252443-lclxrwcm	108	6	mild	mild	JJ
cord-252443-lclxrwcm	108	7	disease	disease	NN
cord-252443-lclxrwcm	108	8	,	,	,
cord-252443-lclxrwcm	108	9	which	which	WDT
cord-252443-lclxrwcm	108	10	is	be	VBZ
cord-252443-lclxrwcm	108	11	promptly	promptly	RB
cord-252443-lclxrwcm	108	12	resolved	resolve	VBN
cord-252443-lclxrwcm	108	13	;	;	:
cord-252443-lclxrwcm	108	14	however	however	RB
cord-252443-lclxrwcm	108	15	,	,	,
cord-252443-lclxrwcm	108	16	infection	infection	NN
cord-252443-lclxrwcm	108	17	of	of	IN
cord-252443-lclxrwcm	108	18	immunocompromised	immunocompromised	JJ
cord-252443-lclxrwcm	108	19	individuals	individual	NNS
cord-252443-lclxrwcm	108	20	can	can	MD
cord-252443-lclxrwcm	108	21	result	result	VB
cord-252443-lclxrwcm	108	22	in	in	IN
cord-252443-lclxrwcm	108	23	more	more	JJR
cord-252443-lclxrwcm	108	24	severe	severe	JJ
cord-252443-lclxrwcm	108	25	disease	disease	NN
cord-252443-lclxrwcm	108	26	(	(	-LRB-
cord-252443-lclxrwcm	108	27	88	88	CD
cord-252443-lclxrwcm	108	28	,	,	,
cord-252443-lclxrwcm	108	29	89	89	CD
cord-252443-lclxrwcm	108	30	)	)	-RRB-
cord-252443-lclxrwcm	108	31	.	.	.
cord-252443-lclxrwcm	109	1	Several	several	JJ
cord-252443-lclxrwcm	109	2	properties	property	NNS
cord-252443-lclxrwcm	109	3	of	of	IN
cord-252443-lclxrwcm	109	4	Ad	ad	NN
cord-252443-lclxrwcm	109	5	viruses	virus	NNS
cord-252443-lclxrwcm	109	6	are	be	VBP
cord-252443-lclxrwcm	109	7	attractive	attractive	JJ
cord-252443-lclxrwcm	109	8	for	for	IN
cord-252443-lclxrwcm	109	9	vaccine	vaccine	NN
cord-252443-lclxrwcm	109	10	use	use	NN
cord-252443-lclxrwcm	109	11	,	,	,
cord-252443-lclxrwcm	109	12	including	include	VBG
cord-252443-lclxrwcm	109	13	relative	relative	JJ
cord-252443-lclxrwcm	109	14	ease	ease	NN
cord-252443-lclxrwcm	109	15	of	of	IN
cord-252443-lclxrwcm	109	16	manipulation	manipulation	NN
cord-252443-lclxrwcm	109	17	,	,	,
cord-252443-lclxrwcm	109	18	infection	infection	NN
cord-252443-lclxrwcm	109	19	of	of	IN
cord-252443-lclxrwcm	109	20	both	both	DT
cord-252443-lclxrwcm	109	21	dividing	divide	VBG
cord-252443-lclxrwcm	109	22	and	and	CC
cord-252443-lclxrwcm	109	23	nondividing	nondividing	NN
cord-252443-lclxrwcm	109	24	cells	cell	NNS
cord-252443-lclxrwcm	109	25	,	,	,
cord-252443-lclxrwcm	109	26	high	high	JJ
cord-252443-lclxrwcm	109	27	levels	level	NNS
cord-252443-lclxrwcm	109	28	of	of	IN
cord-252443-lclxrwcm	109	29	transgene	transgene	NN
cord-252443-lclxrwcm	109	30	expression	expression	NN
cord-252443-lclxrwcm	109	31	,	,	,
cord-252443-lclxrwcm	109	32	ability	ability	NN
cord-252443-lclxrwcm	109	33	to	to	TO
cord-252443-lclxrwcm	109	34	grow	grow	VB
cord-252443-lclxrwcm	109	35	to	to	IN
cord-252443-lclxrwcm	109	36	high	high	JJ
cord-252443-lclxrwcm	109	37	titers	titer	NNS
cord-252443-lclxrwcm	109	38	in	in	IN
cord-252443-lclxrwcm	109	39	vitro	vitro	NN
cord-252443-lclxrwcm	109	40	and	and	CC
cord-252443-lclxrwcm	109	41	lack	lack	NN
cord-252443-lclxrwcm	109	42	of	of	IN
cord-252443-lclxrwcm	109	43	integration	integration	NN
cord-252443-lclxrwcm	109	44	in	in	IN
cord-252443-lclxrwcm	109	45	the	the	DT
cord-252443-lclxrwcm	109	46	host	host	NN
cord-252443-lclxrwcm	109	47	genome	genome	NN
cord-252443-lclxrwcm	109	48	and	and	CC
cord-252443-lclxrwcm	109	49	stability	stability	NN
cord-252443-lclxrwcm	109	50	(	(	-LRB-
cord-252443-lclxrwcm	109	51	physical	physical	JJ
cord-252443-lclxrwcm	109	52	and	and	CC
cord-252443-lclxrwcm	109	53	genetic	genetic	JJ
cord-252443-lclxrwcm	109	54	)	)	-RRB-
cord-252443-lclxrwcm	109	55	(	(	-LRB-
cord-252443-lclxrwcm	109	56	87	87	CD
cord-252443-lclxrwcm	109	57	,	,	,
cord-252443-lclxrwcm	109	58	89	89	CD
cord-252443-lclxrwcm	109	59	,	,	,
cord-252443-lclxrwcm	109	60	90	90	CD
cord-252443-lclxrwcm	109	61	)	)	-RRB-
cord-252443-lclxrwcm	109	62	.	.	.
cord-252443-lclxrwcm	110	1	Ads	ad	NNS
cord-252443-lclxrwcm	110	2	are	be	VBP
cord-252443-lclxrwcm	110	3	rendered	render	VBN
cord-252443-lclxrwcm	110	4	replication	replication	NN
cord-252443-lclxrwcm	110	5	defective	defective	JJ
cord-252443-lclxrwcm	110	6	by	by	IN
cord-252443-lclxrwcm	110	7	deletion	deletion	NN
cord-252443-lclxrwcm	110	8	of	of	IN
cord-252443-lclxrwcm	110	9	the	the	DT
cord-252443-lclxrwcm	110	10	E1	e1	NN
cord-252443-lclxrwcm	110	11	region	region	NN
cord-252443-lclxrwcm	110	12	genes	gene	NNS
cord-252443-lclxrwcm	110	13	,	,	,
cord-252443-lclxrwcm	110	14	and	and	CC
cord-252443-lclxrwcm	110	15	although	although	IN
cord-252443-lclxrwcm	110	16	replication	replication	NN
cord-252443-lclxrwcm	110	17	competent	competent	JJ
cord-252443-lclxrwcm	110	18	Ad	ad	NN
cord-252443-lclxrwcm	110	19	vectors	vector	NNS
cord-252443-lclxrwcm	110	20	have	have	VBP
cord-252443-lclxrwcm	110	21	been	be	VBN
cord-252443-lclxrwcm	110	22	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	110	23	to	to	TO
cord-252443-lclxrwcm	110	24	be	be	VB
cord-252443-lclxrwcm	110	25	quantitatively	quantitatively	RB
cord-252443-lclxrwcm	110	26	(	(	-LRB-
cord-252443-lclxrwcm	110	27	reduction	reduction	NN
cord-252443-lclxrwcm	110	28	of	of	IN
cord-252443-lclxrwcm	110	29	required	required	JJ
cord-252443-lclxrwcm	110	30	dose	dose	NN
cord-252443-lclxrwcm	110	31	)	)	-RRB-
cord-252443-lclxrwcm	110	32	and	and	CC
cord-252443-lclxrwcm	110	33	qualitatively	qualitatively	RB
cord-252443-lclxrwcm	110	34	(	(	-LRB-
cord-252443-lclxrwcm	110	35	induction	induction	NN
cord-252443-lclxrwcm	110	36	of	of	IN
cord-252443-lclxrwcm	110	37	sitespecific	sitespecific	JJ
cord-252443-lclxrwcm	110	38	immunity	immunity	NN
cord-252443-lclxrwcm	110	39	)	)	-RRB-
cord-252443-lclxrwcm	110	40	more	more	RBR
cord-252443-lclxrwcm	110	41	effective	effective	JJ
cord-252443-lclxrwcm	110	42	,	,	,
cord-252443-lclxrwcm	110	43	the	the	DT
cord-252443-lclxrwcm	110	44	release	release	NN
cord-252443-lclxrwcm	110	45	of	of	IN
cord-252443-lclxrwcm	110	46	genetically	genetically	RB
cord-252443-lclxrwcm	110	47	modified	modify	VBN
cord-252443-lclxrwcm	110	48	Ad	ad	NN
cord-252443-lclxrwcm	110	49	vectors	vector	NNS
cord-252443-lclxrwcm	110	50	into	into	IN
cord-252443-lclxrwcm	110	51	the	the	DT
cord-252443-lclxrwcm	110	52	general	general	JJ
cord-252443-lclxrwcm	110	53	public	public	NN
cord-252443-lclxrwcm	110	54	,	,	,
cord-252443-lclxrwcm	110	55	fuelling	fuel	VBG
cord-252443-lclxrwcm	110	56	concerns	concern	NNS
cord-252443-lclxrwcm	110	57	of	of	IN
cord-252443-lclxrwcm	110	58	possible	possible	JJ
cord-252443-lclxrwcm	110	59	carriage	carriage	NN
cord-252443-lclxrwcm	110	60	,	,	,
cord-252443-lclxrwcm	110	61	has	have	VBZ
cord-252443-lclxrwcm	110	62	limited	limit	VBN
cord-252443-lclxrwcm	110	63	their	-PRON-	PRP$
cord-252443-lclxrwcm	110	64	systematic	systematic	JJ
cord-252443-lclxrwcm	110	65	use	use	NN
cord-252443-lclxrwcm	110	66	(	(	-LRB-
cord-252443-lclxrwcm	110	67	89	89	CD
cord-252443-lclxrwcm	110	68	,	,	,
cord-252443-lclxrwcm	110	69	90	90	CD
cord-252443-lclxrwcm	110	70	)	)	-RRB-
cord-252443-lclxrwcm	110	71	.	.	.
cord-252443-lclxrwcm	111	1	Nonreplicating	nonreplicate	VBG
cord-252443-lclxrwcm	111	2	human	human	JJ
cord-252443-lclxrwcm	111	3	Ad	ad	NN
cord-252443-lclxrwcm	111	4	(	(	-LRB-
cord-252443-lclxrwcm	111	5	for	for	IN
cord-252443-lclxrwcm	111	6	example	example	NN
cord-252443-lclxrwcm	111	7	,	,	,
cord-252443-lclxrwcm	111	8	Adhu5	Adhu5	NNP
cord-252443-lclxrwcm	111	9	)	)	-RRB-
cord-252443-lclxrwcm	111	10	vectors	vector	NNS
cord-252443-lclxrwcm	111	11	have	have	VBP
cord-252443-lclxrwcm	111	12	been	be	VBN
cord-252443-lclxrwcm	111	13	extensively	extensively	RB
cord-252443-lclxrwcm	111	14	used	use	VBN
cord-252443-lclxrwcm	111	15	in	in	IN
cord-252443-lclxrwcm	111	16	gene	gene	NN
cord-252443-lclxrwcm	111	17	therapy	therapy	NN
cord-252443-lclxrwcm	111	18	applications	application	NNS
cord-252443-lclxrwcm	111	19	,	,	,
cord-252443-lclxrwcm	111	20	but	but	CC
cord-252443-lclxrwcm	111	21	unfortunately	unfortunately	RB
cord-252443-lclxrwcm	111	22	,	,	,
cord-252443-lclxrwcm	111	23	most	most	JJS
cord-252443-lclxrwcm	111	24	adults	adult	NNS
cord-252443-lclxrwcm	111	25	have	have	VBP
cord-252443-lclxrwcm	111	26	high	high	JJ
cord-252443-lclxrwcm	111	27	titers	titer	NNS
cord-252443-lclxrwcm	111	28	of	of	IN
cord-252443-lclxrwcm	111	29	neutralizing	neutralize	VBG
cord-252443-lclxrwcm	111	30	antibodies	antibody	NNS
cord-252443-lclxrwcm	111	31	against	against	IN
cord-252443-lclxrwcm	111	32	a	a	DT
cord-252443-lclxrwcm	111	33	number	number	NN
cord-252443-lclxrwcm	111	34	of	of	IN
cord-252443-lclxrwcm	111	35	Ad	ad	NN
cord-252443-lclxrwcm	111	36	serotypes	serotype	NNS
cord-252443-lclxrwcm	111	37	,	,	,
cord-252443-lclxrwcm	111	38	including	include	VBG
cord-252443-lclxrwcm	111	39	Adhu5	Adhu5	NNP
cord-252443-lclxrwcm	111	40	,	,	,
cord-252443-lclxrwcm	111	41	which	which	WDT
cord-252443-lclxrwcm	111	42	has	have	VBZ
cord-252443-lclxrwcm	111	43	a	a	DT
cord-252443-lclxrwcm	111	44	negative	negative	JJ
cord-252443-lclxrwcm	111	45	impact	impact	NN
cord-252443-lclxrwcm	111	46	on	on	IN
cord-252443-lclxrwcm	111	47	their	-PRON-	PRP$
cord-252443-lclxrwcm	111	48	effectiveness	effectiveness	NN
cord-252443-lclxrwcm	111	49	as	as	IN
cord-252443-lclxrwcm	111	50	vaccine	vaccine	NN
cord-252443-lclxrwcm	111	51	platforms	platform	NNS
cord-252443-lclxrwcm	111	52	(	(	-LRB-
cord-252443-lclxrwcm	111	53	91	91	CD
cord-252443-lclxrwcm	111	54	)	)	-RRB-
cord-252443-lclxrwcm	111	55	.	.	.
cord-252443-lclxrwcm	112	1	To	to	TO
cord-252443-lclxrwcm	112	2	circumvent	circumvent	VB
cord-252443-lclxrwcm	112	3	this	this	DT
cord-252443-lclxrwcm	112	4	limitation	limitation	NN
cord-252443-lclxrwcm	112	5	,	,	,
cord-252443-lclxrwcm	112	6	alternative	alternative	JJ
cord-252443-lclxrwcm	112	7	serotypes	serotype	NNS
cord-252443-lclxrwcm	112	8	of	of	IN
cord-252443-lclxrwcm	112	9	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	112	10	not	not	RB
cord-252443-lclxrwcm	112	11	found	find	VBN
cord-252443-lclxrwcm	112	12	in	in	IN
cord-252443-lclxrwcm	112	13	human	human	JJ
cord-252443-lclxrwcm	112	14	populations	population	NNS
cord-252443-lclxrwcm	112	15	are	be	VBP
cord-252443-lclxrwcm	112	16	being	be	VBG
cord-252443-lclxrwcm	112	17	developed	develop	VBN
cord-252443-lclxrwcm	112	18	(	(	-LRB-
cord-252443-lclxrwcm	112	19	92	92	CD
cord-252443-lclxrwcm	112	20	,	,	,
cord-252443-lclxrwcm	112	21	93	93	CD
cord-252443-lclxrwcm	112	22	)	)	-RRB-
cord-252443-lclxrwcm	112	23	.	.	.
cord-252443-lclxrwcm	113	1	These	these	DT
cord-252443-lclxrwcm	113	2	include	include	VBP
cord-252443-lclxrwcm	113	3	Ads	ad	NNS
cord-252443-lclxrwcm	113	4	of	of	IN
cord-252443-lclxrwcm	113	5	rare	rare	JJ
cord-252443-lclxrwcm	113	6	serotypes	serotype	NNS
cord-252443-lclxrwcm	113	7	(	(	-LRB-
cord-252443-lclxrwcm	113	8	that	that	RB
cord-252443-lclxrwcm	113	9	is	is	RB
cord-252443-lclxrwcm	113	10	,	,	,
cord-252443-lclxrwcm	113	11	Ad11	Ad11	NNP
cord-252443-lclxrwcm	113	12	,	,	,
cord-252443-lclxrwcm	113	13	Ad26	Ad26	NNP
cord-252443-lclxrwcm	113	14	,	,	,
cord-252443-lclxrwcm	113	15	Ad35	Ad35	NNP
cord-252443-lclxrwcm	113	16	,	,	,
cord-252443-lclxrwcm	113	17	Ad28	Ad28	NNP
cord-252443-lclxrwcm	113	18	and	and	CC
cord-252443-lclxrwcm	113	19	Ad49	Ad49	NNP
cord-252443-lclxrwcm	113	20	)	)	-RRB-
cord-252443-lclxrwcm	113	21	and	and	CC
cord-252443-lclxrwcm	113	22	nonhuman	nonhuman	NN
cord-252443-lclxrwcm	113	23	Ads	ad	NNS
cord-252443-lclxrwcm	113	24	,	,	,
cord-252443-lclxrwcm	113	25	principally	principally	RB
cord-252443-lclxrwcm	113	26	of	of	IN
cord-252443-lclxrwcm	113	27	chimpanzee	chimpanzee	NN
cord-252443-lclxrwcm	113	28	origin	origin	NNP
cord-252443-lclxrwcm	113	29	AdC	AdC	NNP
cord-252443-lclxrwcm	113	30	(	(	-LRB-
cord-252443-lclxrwcm	113	31	77	77	CD
cord-252443-lclxrwcm	113	32	,	,	,
cord-252443-lclxrwcm	113	33	87	87	CD
cord-252443-lclxrwcm	113	34	,	,	,
cord-252443-lclxrwcm	113	35	94	94	CD
cord-252443-lclxrwcm	113	36	)	)	-RRB-
cord-252443-lclxrwcm	113	37	.	.	.
cord-252443-lclxrwcm	114	1	In	in	IN
cord-252443-lclxrwcm	114	2	addition	addition	NN
cord-252443-lclxrwcm	114	3	,	,	,
cord-252443-lclxrwcm	114	4	engineered	engineer	VBN
cord-252443-lclxrwcm	114	5	chimeric	chimeric	JJ
cord-252443-lclxrwcm	114	6	vectors	vector	NNS
cord-252443-lclxrwcm	114	7	in	in	IN
cord-252443-lclxrwcm	114	8	which	which	WDT
cord-252443-lclxrwcm	114	9	the	the	DT
cord-252443-lclxrwcm	114	10	Adhu5	Adhu5	NNP
cord-252443-lclxrwcm	114	11	capsid	capsid	NN
cord-252443-lclxrwcm	114	12	has	have	VBZ
cord-252443-lclxrwcm	114	13	been	be	VBN
cord-252443-lclxrwcm	114	14	modified	modify	VBN
cord-252443-lclxrwcm	114	15	(	(	-LRB-
cord-252443-lclxrwcm	114	16	thereby	thereby	RB
cord-252443-lclxrwcm	114	17	reducing	reduce	VBG
cord-252443-lclxrwcm	114	18	the	the	DT
cord-252443-lclxrwcm	114	19	number	number	NN
cord-252443-lclxrwcm	114	20	of	of	IN
cord-252443-lclxrwcm	114	21	antigenic	antigenic	JJ
cord-252443-lclxrwcm	114	22	epitopes	epitope	NNS
cord-252443-lclxrwcm	114	23	previously	previously	RB
cord-252443-lclxrwcm	114	24	seen	see	VBN
cord-252443-lclxrwcm	114	25	by	by	IN
cord-252443-lclxrwcm	114	26	man	man	NN
cord-252443-lclxrwcm	114	27	)	)	-RRB-
cord-252443-lclxrwcm	114	28	are	be	VBP
cord-252443-lclxrwcm	114	29	also	also	RB
cord-252443-lclxrwcm	114	30	being	be	VBG
cord-252443-lclxrwcm	114	31	deployed	deploy	VBN
cord-252443-lclxrwcm	114	32	(	(	-LRB-
cord-252443-lclxrwcm	114	33	77	77	CD
cord-252443-lclxrwcm	114	34	,	,	,
cord-252443-lclxrwcm	114	35	87	87	CD
cord-252443-lclxrwcm	114	36	,	,	,
cord-252443-lclxrwcm	114	37	94	94	CD
cord-252443-lclxrwcm	114	38	)	)	-RRB-
cord-252443-lclxrwcm	114	39	.	.	.
cord-252443-lclxrwcm	115	1	A	a	DT
cord-252443-lclxrwcm	115	2	number	number	NN
cord-252443-lclxrwcm	115	3	of	of	IN
cord-252443-lclxrwcm	115	4	vaccine	vaccine	NN
cord-252443-lclxrwcm	115	5	studies	study	NNS
cord-252443-lclxrwcm	115	6	have	have	VBP
cord-252443-lclxrwcm	115	7	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	115	8	the	the	DT
cord-252443-lclxrwcm	115	9	feasibility	feasibility	NN
cord-252443-lclxrwcm	115	10	of	of	IN
cord-252443-lclxrwcm	115	11	using	use	VBG
cord-252443-lclxrwcm	115	12	recombinant	recombinant	JJ
cord-252443-lclxrwcm	115	13	Ad	ad	NN
cord-252443-lclxrwcm	115	14	vectors	vector	NNS
cord-252443-lclxrwcm	115	15	expressing	express	VBG
cord-252443-lclxrwcm	115	16	influenza	influenza	NN
cord-252443-lclxrwcm	115	17	viral	viral	JJ
cord-252443-lclxrwcm	115	18	proteins	protein	NNS
cord-252443-lclxrwcm	115	19	to	to	TO
cord-252443-lclxrwcm	115	20	protect	protect	VB
cord-252443-lclxrwcm	115	21	model	model	NN
cord-252443-lclxrwcm	115	22	organisms	organism	NNS
cord-252443-lclxrwcm	115	23	from	from	IN
cord-252443-lclxrwcm	115	24	influenza	influenza	NN
cord-252443-lclxrwcm	115	25	challenge	challenge	NN
cord-252443-lclxrwcm	115	26	.	.	.
cord-252443-lclxrwcm	116	1	A	a	DT
cord-252443-lclxrwcm	116	2	recombinant	recombinant	JJ
cord-252443-lclxrwcm	116	3	Ad	ad	NN
cord-252443-lclxrwcm	116	4	vector	vector	NN
cord-252443-lclxrwcm	116	5	expressing	express	VBG
cord-252443-lclxrwcm	116	6	H5N1	H5N1	NNP
cord-252443-lclxrwcm	116	7	HA	HA	NNP
cord-252443-lclxrwcm	116	8	induced	induce	VBD
cord-252443-lclxrwcm	116	9	both	both	CC
cord-252443-lclxrwcm	116	10	cellular	cellular	JJ
cord-252443-lclxrwcm	116	11	and	and	CC
cord-252443-lclxrwcm	116	12	humoral	humoral	JJ
cord-252443-lclxrwcm	116	13	immunity	immunity	NN
cord-252443-lclxrwcm	116	14	and	and	CC
cord-252443-lclxrwcm	116	15	was	be	VBD
cord-252443-lclxrwcm	116	16	protective	protective	JJ
cord-252443-lclxrwcm	116	17	,	,	,
cord-252443-lclxrwcm	116	18	following	follow	VBG
cord-252443-lclxrwcm	116	19	lethal	lethal	JJ
cord-252443-lclxrwcm	116	20	challenge	challenge	NN
cord-252443-lclxrwcm	116	21	,	,	,
cord-252443-lclxrwcm	116	22	in	in	IN
cord-252443-lclxrwcm	116	23	mice	mouse	NNS
cord-252443-lclxrwcm	116	24	and	and	CC
cord-252443-lclxrwcm	116	25	chickens	chicken	NNS
cord-252443-lclxrwcm	116	26	(	(	-LRB-
cord-252443-lclxrwcm	116	27	95	95	CD
cord-252443-lclxrwcm	116	28	)	)	-RRB-
cord-252443-lclxrwcm	116	29	.	.	.
cord-252443-lclxrwcm	117	1	Heterosubtypic	heterosubtypic	JJ
cord-252443-lclxrwcm	117	2	immunity	immunity	NN
cord-252443-lclxrwcm	117	3	toward	toward	IN
cord-252443-lclxrwcm	117	4	certain	certain	JJ
cord-252443-lclxrwcm	117	5	influenza	influenza	NN
cord-252443-lclxrwcm	117	6	viruses	virus	NNS
cord-252443-lclxrwcm	117	7	has	have	VBZ
cord-252443-lclxrwcm	117	8	been	be	VBN
cord-252443-lclxrwcm	117	9	induced	induce	VBN
cord-252443-lclxrwcm	117	10	through	through	IN
cord-252443-lclxrwcm	117	11	in	in	IN
cord-252443-lclxrwcm	117	12	ovo	ovo	NNP
cord-252443-lclxrwcm	117	13	vaccination	vaccination	NN
cord-252443-lclxrwcm	117	14	with	with	IN
cord-252443-lclxrwcm	117	15	a	a	DT
cord-252443-lclxrwcm	117	16	nonreplicating	nonreplicate	VBG
cord-252443-lclxrwcm	117	17	Ad	ad	NN
cord-252443-lclxrwcm	117	18	vector	vector	NN
cord-252443-lclxrwcm	117	19	expressing	express	VBG
cord-252443-lclxrwcm	117	20	HA	HA	NNP
cord-252443-lclxrwcm	117	21	from	from	IN
cord-252443-lclxrwcm	117	22	H5N9	H5N9	NNP
cord-252443-lclxrwcm	117	23	(	(	-LRB-
cord-252443-lclxrwcm	117	24	96	96	CD
cord-252443-lclxrwcm	117	25	)	)	-RRB-
cord-252443-lclxrwcm	117	26	,	,	,
cord-252443-lclxrwcm	117	27	and	and	CC
cord-252443-lclxrwcm	117	28	indeed	indeed	RB
cord-252443-lclxrwcm	117	29	long	long	RB
cord-252443-lclxrwcm	117	30	-	-	HYPH
cord-252443-lclxrwcm	117	31	lasting	last	VBG
cord-252443-lclxrwcm	117	32	immunity	immunity	NN
cord-252443-lclxrwcm	117	33	,	,	,
cord-252443-lclxrwcm	117	34	12	12	CD
cord-252443-lclxrwcm	117	35	months	month	NNS
cord-252443-lclxrwcm	117	36	postimmunization	postimmunization	NN
cord-252443-lclxrwcm	117	37	,	,	,
cord-252443-lclxrwcm	117	38	has	have	VBZ
cord-252443-lclxrwcm	117	39	been	be	VBN
cord-252443-lclxrwcm	117	40	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	117	41	following	follow	VBG
cord-252443-lclxrwcm	117	42	Ad	ad	NN
cord-252443-lclxrwcm	117	43	vaccination	vaccination	NN
cord-252443-lclxrwcm	117	44	(	(	-LRB-
cord-252443-lclxrwcm	117	45	97	97	CD
cord-252443-lclxrwcm	117	46	)	)	-RRB-
cord-252443-lclxrwcm	117	47	.	.	.
cord-252443-lclxrwcm	118	1	The	the	DT
cord-252443-lclxrwcm	118	2	application	application	NN
cord-252443-lclxrwcm	118	3	of	of	IN
cord-252443-lclxrwcm	118	4	Ad	ad	NN
cord-252443-lclxrwcm	118	5	viral	viral	JJ
cord-252443-lclxrwcm	118	6	vectored	vectore	VBN
cord-252443-lclxrwcm	118	7	vaccines	vaccine	NNS
cord-252443-lclxrwcm	118	8	has	have	VBZ
cord-252443-lclxrwcm	118	9	progressed	progress	VBN
cord-252443-lclxrwcm	118	10	to	to	IN
cord-252443-lclxrwcm	118	11	human	human	JJ
cord-252443-lclxrwcm	118	12	studies	study	NNS
cord-252443-lclxrwcm	118	13	,	,	,
cord-252443-lclxrwcm	118	14	and	and	CC
cord-252443-lclxrwcm	118	15	a	a	DT
cord-252443-lclxrwcm	118	16	phase	phase	NN
cord-252443-lclxrwcm	118	17	I	-PRON-	PRP
cord-252443-lclxrwcm	118	18	clinical	clinical	JJ
cord-252443-lclxrwcm	118	19	trial	trial	NN
cord-252443-lclxrwcm	118	20	using	use	VBG
cord-252443-lclxrwcm	118	21	a	a	DT
cord-252443-lclxrwcm	118	22	nonreplicating	nonreplicate	VBG
cord-252443-lclxrwcm	118	23	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	118	24	vectored	vectore	VBN
cord-252443-lclxrwcm	118	25	nasally	nasally	RB
cord-252443-lclxrwcm	118	26	administered	administer	VBN
cord-252443-lclxrwcm	118	27	influenza	influenza	NN
cord-252443-lclxrwcm	118	28	vaccine	vaccine	NN
cord-252443-lclxrwcm	118	29	has	have	VBZ
cord-252443-lclxrwcm	118	30	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	118	31	that	that	IN
cord-252443-lclxrwcm	118	32	the	the	DT
cord-252443-lclxrwcm	118	33	vaccine	vaccine	NN
cord-252443-lclxrwcm	118	34	is	be	VBZ
cord-252443-lclxrwcm	118	35	well	well	RB
cord-252443-lclxrwcm	118	36	tolerated	tolerated	JJ
cord-252443-lclxrwcm	118	37	and	and	CC
cord-252443-lclxrwcm	118	38	efficaciously	efficaciously	RB
cord-252443-lclxrwcm	118	39	induces	induce	VBZ
cord-252443-lclxrwcm	118	40	humoral	humoral	JJ
cord-252443-lclxrwcm	118	41	immunity	immunity	NN
cord-252443-lclxrwcm	118	42	.	.	.
cord-252443-lclxrwcm	119	1	A	a	DT
cord-252443-lclxrwcm	119	2	follow	follow	VB
cord-252443-lclxrwcm	119	3	-	-	HYPH
cord-252443-lclxrwcm	119	4	on	on	RP
cord-252443-lclxrwcm	119	5	trial	trial	NN
cord-252443-lclxrwcm	119	6	evaluating	evaluate	VBG
cord-252443-lclxrwcm	119	7	the	the	DT
cord-252443-lclxrwcm	119	8	dose	dose	JJ
cord-252443-lclxrwcm	119	9	range	range	NN
cord-252443-lclxrwcm	119	10	,	,	,
cord-252443-lclxrwcm	119	11	safety	safety	NN
cord-252443-lclxrwcm	119	12	and	and	CC
cord-252443-lclxrwcm	119	13	im	im	NN
cord-252443-lclxrwcm	119	14	-	-	HYPH
cord-252443-lclxrwcm	119	15	munogenicity	munogenicity	NN
cord-252443-lclxrwcm	119	16	of	of	IN
cord-252443-lclxrwcm	119	17	an	an	DT
cord-252443-lclxrwcm	119	18	intranasally	intranasally	RB
cord-252443-lclxrwcm	119	19	administered	administer	VBN
cord-252443-lclxrwcm	119	20	AdhVN1203/04.H5	AdhVN1203/04.H5	NNP
cord-252443-lclxrwcm	119	21	(	(	-LRB-
cord-252443-lclxrwcm	119	22	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	119	23	vectored	vectore	VBD
cord-252443-lclxrwcm	119	24	H5	H5	NNP
cord-252443-lclxrwcm	119	25	HA	HA	NNP
cord-252443-lclxrwcm	119	26	)	)	-RRB-
cord-252443-lclxrwcm	119	27	in	in	IN
cord-252443-lclxrwcm	119	28	healthy	healthy	JJ
cord-252443-lclxrwcm	119	29	adults	adult	NNS
cord-252443-lclxrwcm	119	30	19	19	CD
cord-252443-lclxrwcm	119	31	-	-	SYM
cord-252443-lclxrwcm	119	32	49	49	CD
cord-252443-lclxrwcm	119	33	years	year	NNS
cord-252443-lclxrwcm	119	34	of	of	IN
cord-252443-lclxrwcm	119	35	age	age	NN
cord-252443-lclxrwcm	119	36	is	be	VBZ
cord-252443-lclxrwcm	119	37	expected	expect	VBN
cord-252443-lclxrwcm	119	38	to	to	TO
cord-252443-lclxrwcm	119	39	be	be	VB
cord-252443-lclxrwcm	119	40	completed	complete	VBN
cord-252443-lclxrwcm	119	41	imminently	imminently	RB
cord-252443-lclxrwcm	120	1	(	(	-LRB-
cord-252443-lclxrwcm	120	2	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-252443-lclxrwcm	120	3	Identifier	Identifier	NNP
cord-252443-lclxrwcm	120	4	:	:	:
cord-252443-lclxrwcm	120	5	NCT00755703	NCT00755703	NNP
cord-252443-lclxrwcm	120	6	)	)	-RRB-
cord-252443-lclxrwcm	120	7	.	.	.
cord-252443-lclxrwcm	121	1	Replication	replication	NN
cord-252443-lclxrwcm	121	2	competent	competent	JJ
cord-252443-lclxrwcm	121	3	Ad	ad	NN
cord-252443-lclxrwcm	121	4	vectors	vector	NNS
cord-252443-lclxrwcm	121	5	,	,	,
cord-252443-lclxrwcm	121	6	in	in	IN
cord-252443-lclxrwcm	121	7	general	general	JJ
cord-252443-lclxrwcm	121	8	,	,	,
cord-252443-lclxrwcm	121	9	induce	induce	VB
cord-252443-lclxrwcm	121	10	stronger	strong	JJR
cord-252443-lclxrwcm	121	11	immune	immune	JJ
cord-252443-lclxrwcm	121	12	responses	response	NNS
cord-252443-lclxrwcm	121	13	and	and	CC
cord-252443-lclxrwcm	121	14	a	a	DT
cord-252443-lclxrwcm	121	15	live	live	NN
cord-252443-lclxrwcm	121	16	,	,	,
cord-252443-lclxrwcm	121	17	replication	replication	NN
cord-252443-lclxrwcm	121	18	competent	competent	JJ
cord-252443-lclxrwcm	121	19	recombinant	recombinant	JJ
cord-252443-lclxrwcm	121	20	Ad	ad	NN
cord-252443-lclxrwcm	121	21	vectored	vectore	VBN
cord-252443-lclxrwcm	121	22	vaccine	vaccine	NN
cord-252443-lclxrwcm	121	23	,	,	,
cord-252443-lclxrwcm	121	24	expressing	express	VBG
cord-252443-lclxrwcm	121	25	the	the	DT
cord-252443-lclxrwcm	121	26	HA	HA	NNP
cord-252443-lclxrwcm	121	27	from	from	IN
cord-252443-lclxrwcm	121	28	H5N1	H5N1	NNP
cord-252443-lclxrwcm	121	29	(	(	-LRB-
cord-252443-lclxrwcm	121	30	Ad4-H5-Vtn	Ad4-H5-Vtn	NNP
cord-252443-lclxrwcm	121	31	)	)	-RRB-
cord-252443-lclxrwcm	121	32	,	,	,
cord-252443-lclxrwcm	121	33	will	will	MD
cord-252443-lclxrwcm	121	34	be	be	VB
cord-252443-lclxrwcm	121	35	administered	administer	VBN
cord-252443-lclxrwcm	121	36	either	either	CC
cord-252443-lclxrwcm	121	37	intranasally	intranasally	RB
cord-252443-lclxrwcm	121	38	or	or	CC
cord-252443-lclxrwcm	121	39	tonsillarly	tonsillarly	RB
cord-252443-lclxrwcm	121	40	in	in	IN
cord-252443-lclxrwcm	121	41	a	a	DT
cord-252443-lclxrwcm	121	42	phase	phase	NN
cord-252443-lclxrwcm	121	43	1	1	CD
cord-252443-lclxrwcm	121	44	randomized	randomized	JJ
cord-252443-lclxrwcm	121	45	,	,	,
cord-252443-lclxrwcm	121	46	dose	dose	NN
cord-252443-lclxrwcm	121	47	-	-	HYPH
cord-252443-lclxrwcm	121	48	escalation	escalation	NN
cord-252443-lclxrwcm	121	49	study	study	NN
cord-252443-lclxrwcm	121	50	expected	expect	VBN
cord-252443-lclxrwcm	121	51	to	to	TO
cord-252443-lclxrwcm	121	52	be	be	VB
cord-252443-lclxrwcm	121	53	completed	complete	VBN
cord-252443-lclxrwcm	121	54	in	in	IN
cord-252443-lclxrwcm	121	55	2014	2014	CD
cord-252443-lclxrwcm	121	56	(	(	-LRB-
cord-252443-lclxrwcm	121	57	Clinical-Trials.gov	Clinical-Trials.gov	NNP
cord-252443-lclxrwcm	121	58	Identifier	identifier	NN
cord-252443-lclxrwcm	121	59	:	:	:
cord-252443-lclxrwcm	121	60	NCT01443936	NCT01443936	NNS
cord-252443-lclxrwcm	121	61	)	)	-RRB-
cord-252443-lclxrwcm	121	62	.	.	.
cord-252443-lclxrwcm	122	1	Poxviruses	poxvirus	NNS
cord-252443-lclxrwcm	122	2	are	be	VBP
cord-252443-lclxrwcm	122	3	among	among	IN
cord-252443-lclxrwcm	122	4	the	the	DT
cord-252443-lclxrwcm	122	5	most	most	RBS
cord-252443-lclxrwcm	122	6	heavily	heavily	RB
cord-252443-lclxrwcm	122	7	exploited	exploit	VBN
cord-252443-lclxrwcm	122	8	viral	viral	JJ
cord-252443-lclxrwcm	122	9	vectors	vector	NNS
cord-252443-lclxrwcm	122	10	,	,	,
cord-252443-lclxrwcm	122	11	largely	largely	RB
cord-252443-lclxrwcm	122	12	because	because	IN
cord-252443-lclxrwcm	122	13	of	of	IN
cord-252443-lclxrwcm	122	14	the	the	DT
cord-252443-lclxrwcm	122	15	overwhelming	overwhelming	JJ
cord-252443-lclxrwcm	122	16	success	success	NN
cord-252443-lclxrwcm	122	17	of	of	IN
cord-252443-lclxrwcm	122	18	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	122	19	virus	virus	NN
cord-252443-lclxrwcm	122	20	in	in	IN
cord-252443-lclxrwcm	122	21	eradicating	eradicate	VBG
cord-252443-lclxrwcm	122	22	smallpox	smallpox	NN
cord-252443-lclxrwcm	122	23	(	(	-LRB-
cord-252443-lclxrwcm	122	24	87	87	CD
cord-252443-lclxrwcm	122	25	,	,	,
cord-252443-lclxrwcm	122	26	98	98	CD
cord-252443-lclxrwcm	122	27	)	)	-RRB-
cord-252443-lclxrwcm	122	28	.	.	.
cord-252443-lclxrwcm	123	1	As	as	IN
cord-252443-lclxrwcm	123	2	large	large	JJ
cord-252443-lclxrwcm	123	3	DNA	dna	NN
cord-252443-lclxrwcm	123	4	viruses	virus	NNS
cord-252443-lclxrwcm	123	5	,	,	,
cord-252443-lclxrwcm	123	6	poxviruses	poxvirus	NNS
cord-252443-lclxrwcm	123	7	can	can	MD
cord-252443-lclxrwcm	123	8	easily	easily	RB
cord-252443-lclxrwcm	123	9	accommodate	accommodate	VB
cord-252443-lclxrwcm	123	10	substantial	substantial	JJ
cord-252443-lclxrwcm	123	11	amounts	amount	NNS
cord-252443-lclxrwcm	123	12	(	(	-LRB-
cord-252443-lclxrwcm	123	13	over	over	IN
cord-252443-lclxrwcm	123	14	25	25	CD
cord-252443-lclxrwcm	123	15	kb	kb	NNP
cord-252443-lclxrwcm	123	16	)	)	-RRB-
cord-252443-lclxrwcm	123	17	of	of	IN
cord-252443-lclxrwcm	123	18	extra	extra	JJ
cord-252443-lclxrwcm	123	19	DNA	dna	NN
cord-252443-lclxrwcm	123	20	(	(	-LRB-
cord-252443-lclxrwcm	123	21	99	99	CD
cord-252443-lclxrwcm	123	22	)	)	-RRB-
cord-252443-lclxrwcm	123	23	,	,	,
cord-252443-lclxrwcm	123	24	thus	thus	RB
cord-252443-lclxrwcm	123	25	facilitating	facilitate	VBG
cord-252443-lclxrwcm	123	26	a	a	DT
cord-252443-lclxrwcm	123	27	multivalent	multivalent	JJ
cord-252443-lclxrwcm	123	28	vaccine	vaccine	NN
cord-252443-lclxrwcm	123	29	approach	approach	NN
cord-252443-lclxrwcm	123	30	through	through	IN
cord-252443-lclxrwcm	123	31	the	the	DT
cord-252443-lclxrwcm	123	32	simultaneous	simultaneous	JJ
cord-252443-lclxrwcm	123	33	expression	expression	NN
cord-252443-lclxrwcm	123	34	of	of	IN
cord-252443-lclxrwcm	123	35	multiple	multiple	JJ
cord-252443-lclxrwcm	123	36	transgenes	transgene	NNS
cord-252443-lclxrwcm	123	37	(	(	-LRB-
cord-252443-lclxrwcm	123	38	100	100	CD
cord-252443-lclxrwcm	123	39	,	,	,
cord-252443-lclxrwcm	123	40	101	101	CD
cord-252443-lclxrwcm	123	41	)	)	-RRB-
cord-252443-lclxrwcm	123	42	.	.	.
cord-252443-lclxrwcm	124	1	Poxviruses	poxvirus	NNS
cord-252443-lclxrwcm	124	2	replicate	replicate	VBP
cord-252443-lclxrwcm	124	3	within	within	IN
cord-252443-lclxrwcm	124	4	the	the	DT
cord-252443-lclxrwcm	124	5	cytoplasm	cytoplasm	NN
cord-252443-lclxrwcm	124	6	of	of	IN
cord-252443-lclxrwcm	124	7	infected	infected	JJ
cord-252443-lclxrwcm	124	8	cells	cell	NNS
cord-252443-lclxrwcm	124	9	and	and	CC
cord-252443-lclxrwcm	124	10	do	do	VBP
cord-252443-lclxrwcm	124	11	not	not	RB
cord-252443-lclxrwcm	124	12	integrate	integrate	VB
cord-252443-lclxrwcm	124	13	into	into	IN
cord-252443-lclxrwcm	124	14	the	the	DT
cord-252443-lclxrwcm	124	15	host	host	NN
cord-252443-lclxrwcm	124	16	genome	genome	NN
cord-252443-lclxrwcm	124	17	,	,	,
cord-252443-lclxrwcm	124	18	eliminating	eliminate	VBG
cord-252443-lclxrwcm	124	19	the	the	DT
cord-252443-lclxrwcm	124	20	potential	potential	NN
cord-252443-lclxrwcm	124	21	for	for	IN
cord-252443-lclxrwcm	124	22	insertional	insertional	JJ
cord-252443-lclxrwcm	124	23	mutagenesis	mutagenesis	NN
cord-252443-lclxrwcm	124	24	.	.	.
cord-252443-lclxrwcm	125	1	They	-PRON-	PRP
cord-252443-lclxrwcm	125	2	have	have	VBP
cord-252443-lclxrwcm	125	3	been	be	VBN
cord-252443-lclxrwcm	125	4	developed	develop	VBN
cord-252443-lclxrwcm	125	5	as	as	IN
cord-252443-lclxrwcm	125	6	vaccines	vaccine	NNS
cord-252443-lclxrwcm	125	7	through	through	IN
cord-252443-lclxrwcm	125	8	two	two	CD
cord-252443-lclxrwcm	125	9	different	different	JJ
cord-252443-lclxrwcm	125	10	approaches	approach	NNS
cord-252443-lclxrwcm	125	11	;	;	:
cord-252443-lclxrwcm	126	1	the	the	DT
cord-252443-lclxrwcm	126	2	first	first	JJ
cord-252443-lclxrwcm	126	3	relies	rely	VBZ
cord-252443-lclxrwcm	126	4	on	on	IN
cord-252443-lclxrwcm	126	5	productive	productive	JJ
cord-252443-lclxrwcm	126	6	replication	replication	NN
cord-252443-lclxrwcm	126	7	of	of	IN
cord-252443-lclxrwcm	126	8	an	an	DT
cord-252443-lclxrwcm	126	9	attenuated	attenuated	JJ
cord-252443-lclxrwcm	126	10	strain	strain	NN
cord-252443-lclxrwcm	126	11	in	in	IN
cord-252443-lclxrwcm	126	12	a	a	DT
cord-252443-lclxrwcm	126	13	permissive	permissive	JJ
cord-252443-lclxrwcm	126	14	host	host	NN
cord-252443-lclxrwcm	126	15	.	.	.
cord-252443-lclxrwcm	127	1	The	the	DT
cord-252443-lclxrwcm	127	2	second	second	JJ
cord-252443-lclxrwcm	127	3	uses	use	VBZ
cord-252443-lclxrwcm	127	4	replication	replication	NN
cord-252443-lclxrwcm	127	5	-	-	HYPH
cord-252443-lclxrwcm	127	6	defective	defective	JJ
cord-252443-lclxrwcm	127	7	poxviruses	poxvirus	NNS
cord-252443-lclxrwcm	127	8	,	,	,
cord-252443-lclxrwcm	127	9	which	which	WDT
cord-252443-lclxrwcm	127	10	may	may	MD
cord-252443-lclxrwcm	127	11	enter	enter	VB
cord-252443-lclxrwcm	127	12	cells	cell	NNS
cord-252443-lclxrwcm	127	13	of	of	IN
cord-252443-lclxrwcm	127	14	nonpermissive	nonpermissive	JJ
cord-252443-lclxrwcm	127	15	hosts	host	NNS
cord-252443-lclxrwcm	127	16	and	and	CC
cord-252443-lclxrwcm	127	17	express	express	VBP
cord-252443-lclxrwcm	127	18	encoded	encoded	JJ
cord-252443-lclxrwcm	127	19	proteins	protein	NNS
cord-252443-lclxrwcm	127	20	,	,	,
cord-252443-lclxrwcm	127	21	but	but	CC
cord-252443-lclxrwcm	127	22	do	do	VBP
cord-252443-lclxrwcm	127	23	not	not	RB
cord-252443-lclxrwcm	127	24	produce	produce	VB
cord-252443-lclxrwcm	127	25	infectious	infectious	JJ
cord-252443-lclxrwcm	127	26	virus	virus	NN
cord-252443-lclxrwcm	127	27	(	(	-LRB-
cord-252443-lclxrwcm	127	28	98	98	CD
cord-252443-lclxrwcm	127	29	,	,	,
cord-252443-lclxrwcm	127	30	102	102	CD
cord-252443-lclxrwcm	127	31	)	)	-RRB-
cord-252443-lclxrwcm	127	32	.	.	.
cord-252443-lclxrwcm	128	1	Modified	modified	JJ
cord-252443-lclxrwcm	128	2	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	128	3	virus	virus	NN
cord-252443-lclxrwcm	128	4	Ankara	Ankara	NNP
cord-252443-lclxrwcm	128	5	(	(	-LRB-
cord-252443-lclxrwcm	128	6	MVA	MVA	NNP
cord-252443-lclxrwcm	128	7	)	)	-RRB-
cord-252443-lclxrwcm	128	8	,	,	,
cord-252443-lclxrwcm	128	9	an	an	DT
cord-252443-lclxrwcm	128	10	attenuated	attenuated	JJ
cord-252443-lclxrwcm	128	11	strain	strain	NN
cord-252443-lclxrwcm	128	12	of	of	IN
cord-252443-lclxrwcm	128	13	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	128	14	virus	virus	NN
cord-252443-lclxrwcm	128	15	,	,	,
cord-252443-lclxrwcm	128	16	was	be	VBD
cord-252443-lclxrwcm	128	17	originally	originally	RB
cord-252443-lclxrwcm	128	18	developed	develop	VBN
cord-252443-lclxrwcm	128	19	during	during	IN
cord-252443-lclxrwcm	128	20	the	the	DT
cord-252443-lclxrwcm	128	21	smallpox	smallpox	NN
cord-252443-lclxrwcm	128	22	eradication	eradication	NN
cord-252443-lclxrwcm	128	23	campaign	campaign	NN
cord-252443-lclxrwcm	128	24	,	,	,
cord-252443-lclxrwcm	128	25	because	because	IN
cord-252443-lclxrwcm	128	26	wild	wild	JJ
cord-252443-lclxrwcm	128	27	-	-	HYPH
cord-252443-lclxrwcm	128	28	type	type	NN
cord-252443-lclxrwcm	128	29	strains	strain	NNS
cord-252443-lclxrwcm	128	30	can	can	MD
cord-252443-lclxrwcm	128	31	produce	produce	VB
cord-252443-lclxrwcm	128	32	undesirable	undesirable	JJ
cord-252443-lclxrwcm	128	33	effects	effect	NNS
cord-252443-lclxrwcm	128	34	in	in	IN
cord-252443-lclxrwcm	128	35	humans	human	NNS
cord-252443-lclxrwcm	128	36	(	(	-LRB-
cord-252443-lclxrwcm	128	37	103	103	CD
cord-252443-lclxrwcm	128	38	,	,	,
cord-252443-lclxrwcm	128	39	104	104	CD
cord-252443-lclxrwcm	128	40	)	)	-RRB-
cord-252443-lclxrwcm	128	41	.	.	.
cord-252443-lclxrwcm	129	1	Attenuated	attenuated	JJ
cord-252443-lclxrwcm	129	2	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	129	3	strains	strain	NNS
cord-252443-lclxrwcm	129	4	such	such	JJ
cord-252443-lclxrwcm	129	5	as	as	IN
cord-252443-lclxrwcm	129	6	MVA	MVA	NNP
cord-252443-lclxrwcm	129	7	undergo	undergo	VBP
cord-252443-lclxrwcm	129	8	very	very	RB
cord-252443-lclxrwcm	129	9	limited	limited	JJ
cord-252443-lclxrwcm	129	10	,	,	,
cord-252443-lclxrwcm	129	11	or	or	CC
cord-252443-lclxrwcm	129	12	nonproductive	nonproductive	JJ
cord-252443-lclxrwcm	129	13	,	,	,
cord-252443-lclxrwcm	129	14	replication	replication	NN
cord-252443-lclxrwcm	129	15	in	in	IN
cord-252443-lclxrwcm	129	16	mammalian	mammalian	JJ
cord-252443-lclxrwcm	129	17	cells	cell	NNS
cord-252443-lclxrwcm	129	18	(	(	-LRB-
cord-252443-lclxrwcm	129	19	102	102	CD
cord-252443-lclxrwcm	129	20	)	)	-RRB-
cord-252443-lclxrwcm	129	21	,	,	,
cord-252443-lclxrwcm	129	22	although	although	IN
cord-252443-lclxrwcm	129	23	most	most	JJS
cord-252443-lclxrwcm	129	24	of	of	IN
cord-252443-lclxrwcm	129	25	the	the	DT
cord-252443-lclxrwcm	129	26	virus	virus	NN
cord-252443-lclxrwcm	129	27	proteins	protein	NNS
cord-252443-lclxrwcm	129	28	are	be	VBP
cord-252443-lclxrwcm	129	29	produced	produce	VBN
cord-252443-lclxrwcm	129	30	,	,	,
cord-252443-lclxrwcm	129	31	including	include	VBG
cord-252443-lclxrwcm	129	32	inserted	insert	VBN
cord-252443-lclxrwcm	129	33	transgenes	transgene	NNS
cord-252443-lclxrwcm	129	34	(	(	-LRB-
cord-252443-lclxrwcm	129	35	98	98	CD
cord-252443-lclxrwcm	129	36	)	)	-RRB-
cord-252443-lclxrwcm	129	37	.	.	.
cord-252443-lclxrwcm	130	1	MVA	MVA	NNP
cord-252443-lclxrwcm	130	2	has	have	VBZ
cord-252443-lclxrwcm	130	3	an	an	DT
cord-252443-lclxrwcm	130	4	excellent	excellent	JJ
cord-252443-lclxrwcm	130	5	safety	safety	NN
cord-252443-lclxrwcm	130	6	profile	profile	NN
cord-252443-lclxrwcm	130	7	in	in	IN
cord-252443-lclxrwcm	130	8	humans	human	NNS
cord-252443-lclxrwcm	130	9	,	,	,
cord-252443-lclxrwcm	130	10	having	have	VBG
cord-252443-lclxrwcm	130	11	been	be	VBN
cord-252443-lclxrwcm	130	12	used	use	VBN
cord-252443-lclxrwcm	130	13	in	in	IN
cord-252443-lclxrwcm	130	14	many	many	JJ
cord-252443-lclxrwcm	130	15	field	field	NN
cord-252443-lclxrwcm	130	16	studies	study	NNS
cord-252443-lclxrwcm	130	17	(	(	-LRB-
cord-252443-lclxrwcm	130	18	105	105	CD
cord-252443-lclxrwcm	130	19	,	,	,
cord-252443-lclxrwcm	130	20	106	106	CD
cord-252443-lclxrwcm	130	21	)	)	-RRB-
cord-252443-lclxrwcm	131	1	-safety	-safety	NNP
cord-252443-lclxrwcm	131	2	has	have	VBZ
cord-252443-lclxrwcm	131	3	also	also	RB
cord-252443-lclxrwcm	131	4	been	be	VBN
cord-252443-lclxrwcm	131	5	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	131	6	in	in	IN
cord-252443-lclxrwcm	131	7	studies	study	NNS
cord-252443-lclxrwcm	131	8	with	with	IN
cord-252443-lclxrwcm	131	9	immunocompromised	immunocompromised	JJ
cord-252443-lclxrwcm	131	10	macaques	macaque	NNS
cord-252443-lclxrwcm	131	11	and	and	CC
cord-252443-lclxrwcm	131	12	humans	human	NNS
cord-252443-lclxrwcm	131	13	(	(	-LRB-
cord-252443-lclxrwcm	131	14	107	107	CD
cord-252443-lclxrwcm	131	15	,	,	,
cord-252443-lclxrwcm	131	16	108	108	CD
cord-252443-lclxrwcm	131	17	)	)	-RRB-
cord-252443-lclxrwcm	131	18	.	.	.
cord-252443-lclxrwcm	132	1	One	one	CD
cord-252443-lclxrwcm	132	2	of	of	IN
cord-252443-lclxrwcm	132	3	the	the	DT
cord-252443-lclxrwcm	132	4	ongoing	ongoing	JJ
cord-252443-lclxrwcm	132	5	concerns	concern	NNS
cord-252443-lclxrwcm	132	6	with	with	IN
cord-252443-lclxrwcm	132	7	viral	viral	JJ
cord-252443-lclxrwcm	132	8	vector	vector	NN
cord-252443-lclxrwcm	132	9	vaccines	vaccine	NNS
cord-252443-lclxrwcm	132	10	is	be	VBZ
cord-252443-lclxrwcm	132	11	their	-PRON-	PRP$
cord-252443-lclxrwcm	132	12	applicability	applicability	NN
cord-252443-lclxrwcm	132	13	for	for	IN
cord-252443-lclxrwcm	132	14	repeat	repeat	NN
cord-252443-lclxrwcm	132	15	vaccinations	vaccination	NNS
cord-252443-lclxrwcm	132	16	.	.	.
cord-252443-lclxrwcm	133	1	Preclinical	preclinical	JJ
cord-252443-lclxrwcm	133	2	evaluation	evaluation	NN
cord-252443-lclxrwcm	133	3	of	of	IN
cord-252443-lclxrwcm	133	4	MVA	MVA	NNP
cord-252443-lclxrwcm	133	5	vectors	vector	NNS
cord-252443-lclxrwcm	133	6	has	have	VBZ
cord-252443-lclxrwcm	133	7	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	133	8	their	-PRON-	PRP$
cord-252443-lclxrwcm	133	9	ability	ability	NN
cord-252443-lclxrwcm	133	10	to	to	TO
cord-252443-lclxrwcm	133	11	repeatedly	repeatedly	RB
cord-252443-lclxrwcm	133	12	boost	boost	VB
cord-252443-lclxrwcm	133	13	immune	immune	JJ
cord-252443-lclxrwcm	133	14	responses	response	NNS
cord-252443-lclxrwcm	133	15	directed	direct	VBN
cord-252443-lclxrwcm	133	16	to	to	IN
cord-252443-lclxrwcm	133	17	recombinant	recombinant	JJ
cord-252443-lclxrwcm	133	18	antigens	antigen	NNS
cord-252443-lclxrwcm	133	19	(	(	-LRB-
cord-252443-lclxrwcm	133	20	109	109	CD
cord-252443-lclxrwcm	133	21	,	,	,
cord-252443-lclxrwcm	133	22	110	110	CD
cord-252443-lclxrwcm	133	23	)	)	-RRB-
cord-252443-lclxrwcm	133	24	.	.	.
cord-252443-lclxrwcm	134	1	Indeed	indeed	RB
cord-252443-lclxrwcm	134	2	,	,	,
cord-252443-lclxrwcm	134	3	two	two	CD
cord-252443-lclxrwcm	134	4	phase	phase	NN
cord-252443-lclxrwcm	134	5	I	-PRON-	PRP
cord-252443-lclxrwcm	134	6	clinical	clinical	JJ
cord-252443-lclxrwcm	134	7	trials	trial	NNS
cord-252443-lclxrwcm	134	8	using	use	VBG
cord-252443-lclxrwcm	134	9	repeat	repeat	NN
cord-252443-lclxrwcm	134	10	vaccination	vaccination	NN
cord-252443-lclxrwcm	134	11	with	with	IN
cord-252443-lclxrwcm	134	12	MVA	MVA	NNP
cord-252443-lclxrwcm	134	13	vectored	vectore	VBD
cord-252443-lclxrwcm	134	14	vaccines	vaccine	NNS
cord-252443-lclxrwcm	134	15	,	,	,
cord-252443-lclxrwcm	134	16	at	at	IN
cord-252443-lclxrwcm	134	17	6	6	CD
cord-252443-lclxrwcm	134	18	-	-	SYM
cord-252443-lclxrwcm	134	19	8	8	CD
cord-252443-lclxrwcm	134	20	months	month	NNS
cord-252443-lclxrwcm	134	21	,	,	,
cord-252443-lclxrwcm	134	22	demonstrate	demonstrate	VBP
cord-252443-lclxrwcm	134	23	an	an	DT
cord-252443-lclxrwcm	134	24	ability	ability	NN
cord-252443-lclxrwcm	134	25	to	to	TO
cord-252443-lclxrwcm	134	26	boost	boost	VB
cord-252443-lclxrwcm	134	27	T	t	NN
cord-252443-lclxrwcm	134	28	-	-	HYPH
cord-252443-lclxrwcm	134	29	cell	cell	NN
cord-252443-lclxrwcm	134	30	responses	response	NNS
cord-252443-lclxrwcm	134	31	(	(	-LRB-
cord-252443-lclxrwcm	134	32	111	111	CD
cord-252443-lclxrwcm	134	33	,	,	,
cord-252443-lclxrwcm	134	34	112	112	CD
cord-252443-lclxrwcm	134	35	)	)	-RRB-
cord-252443-lclxrwcm	134	36	.	.	.
cord-252443-lclxrwcm	135	1	These	these	DT
cord-252443-lclxrwcm	135	2	data	datum	NNS
cord-252443-lclxrwcm	135	3	suggest	suggest	VBP
cord-252443-lclxrwcm	135	4	that	that	IN
cord-252443-lclxrwcm	135	5	vector	vector	NN
cord-252443-lclxrwcm	135	6	-	-	HYPH
cord-252443-lclxrwcm	135	7	specific	specific	JJ
cord-252443-lclxrwcm	135	8	immunity	immunity	NN
cord-252443-lclxrwcm	135	9	does	do	VBZ
cord-252443-lclxrwcm	135	10	not	not	RB
cord-252443-lclxrwcm	135	11	greatly	greatly	RB
cord-252443-lclxrwcm	135	12	impede	impede	VB
cord-252443-lclxrwcm	135	13	immune	immune	JJ
cord-252443-lclxrwcm	135	14	responses	response	NNS
cord-252443-lclxrwcm	135	15	toward	toward	IN
cord-252443-lclxrwcm	135	16	target	target	NN
cord-252443-lclxrwcm	135	17	antigens	antigen	NNS
cord-252443-lclxrwcm	135	18	.	.	.
cord-252443-lclxrwcm	136	1	A	a	DT
cord-252443-lclxrwcm	136	2	major	major	JJ
cord-252443-lclxrwcm	136	3	advantage	advantage	NN
cord-252443-lclxrwcm	136	4	of	of	IN
cord-252443-lclxrwcm	136	5	MVA	MVA	NNP
cord-252443-lclxrwcm	136	6	over	over	IN
cord-252443-lclxrwcm	136	7	other	other	JJ
cord-252443-lclxrwcm	136	8	vaccine	vaccine	NN
cord-252443-lclxrwcm	136	9	preparations	preparation	NNS
cord-252443-lclxrwcm	136	10	is	be	VBZ
cord-252443-lclxrwcm	136	11	that	that	IN
cord-252443-lclxrwcm	136	12	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	136	13	are	be	VBP
cord-252443-lclxrwcm	136	14	not	not	RB
cord-252443-lclxrwcm	136	15	required	require	VBN
cord-252443-lclxrwcm	136	16	for	for	IN
cord-252443-lclxrwcm	136	17	high	high	JJ
cord-252443-lclxrwcm	136	18	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	136	19	,	,	,
cord-252443-lclxrwcm	136	20	because	because	IN
cord-252443-lclxrwcm	136	21	MVA	MVA	NNP
cord-252443-lclxrwcm	136	22	has	have	VBZ
cord-252443-lclxrwcm	136	23	immunostimulatory	immunostimulatory	NNP
cord-252443-lclxrwcm	136	24	properties	property	NNS
cord-252443-lclxrwcm	136	25	(	(	-LRB-
cord-252443-lclxrwcm	136	26	84	84	CD
cord-252443-lclxrwcm	136	27	,	,	,
cord-252443-lclxrwcm	136	28	85	85	CD
cord-252443-lclxrwcm	136	29	)	)	-RRB-
cord-252443-lclxrwcm	136	30	and	and	CC
cord-252443-lclxrwcm	136	31	can	can	MD
cord-252443-lclxrwcm	136	32	elicit	elicit	VB
cord-252443-lclxrwcm	136	33	potent	potent	JJ
cord-252443-lclxrwcm	136	34	humoral	humoral	JJ
cord-252443-lclxrwcm	136	35	and	and	CC
cord-252443-lclxrwcm	136	36	antigen	antigen	NN
cord-252443-lclxrwcm	136	37	-	-	HYPH
cord-252443-lclxrwcm	136	38	specific	specific	JJ
cord-252443-lclxrwcm	136	39	T	t	NN
cord-252443-lclxrwcm	136	40	-	-	HYPH
cord-252443-lclxrwcm	136	41	cell	cell	NN
cord-252443-lclxrwcm	136	42	responses	response	NNS
cord-252443-lclxrwcm	136	43	(	(	-LRB-
cord-252443-lclxrwcm	136	44	110	110	CD
cord-252443-lclxrwcm	136	45	,	,	,
cord-252443-lclxrwcm	136	46	113	113	CD
cord-252443-lclxrwcm	136	47	)	)	-RRB-
cord-252443-lclxrwcm	136	48	.	.	.
cord-252443-lclxrwcm	137	1	For	for	IN
cord-252443-lclxrwcm	137	2	the	the	DT
cord-252443-lclxrwcm	137	3	efficient	efficient	JJ
cord-252443-lclxrwcm	137	4	activation	activation	NN
cord-252443-lclxrwcm	137	5	of	of	IN
cord-252443-lclxrwcm	137	6	CD8	CD8	NNP
cord-252443-lclxrwcm	137	7	+	+	CC
cord-252443-lclxrwcm	137	8	T	t	NN
cord-252443-lclxrwcm	137	9	-	-	HYPH
cord-252443-lclxrwcm	137	10	cell	cell	NN
cord-252443-lclxrwcm	137	11	responses	response	NNS
cord-252443-lclxrwcm	137	12	with	with	IN
cord-252443-lclxrwcm	137	13	MVA	MVA	NNP
cord-252443-lclxrwcm	137	14	vectors	vector	NNS
cord-252443-lclxrwcm	137	15	,	,	,
cord-252443-lclxrwcm	137	16	delivery	delivery	NN
cord-252443-lclxrwcm	137	17	of	of	IN
cord-252443-lclxrwcm	137	18	full	full	JJ
cord-252443-lclxrwcm	137	19	length	length	NN
cord-252443-lclxrwcm	137	20	antigen	antigen	NN
cord-252443-lclxrwcm	137	21	is	be	VBZ
cord-252443-lclxrwcm	137	22	generally	generally	RB
cord-252443-lclxrwcm	137	23	found	find	VBN
cord-252443-lclxrwcm	137	24	to	to	TO
cord-252443-lclxrwcm	137	25	be	be	VB
cord-252443-lclxrwcm	137	26	superior	superior	JJ
cord-252443-lclxrwcm	137	27	,	,	,
cord-252443-lclxrwcm	137	28	suggesting	suggest	VBG
cord-252443-lclxrwcm	137	29	that	that	IN
cord-252443-lclxrwcm	137	30	cross	cross	NN
cord-252443-lclxrwcm	137	31	-	-	JJ
cord-252443-lclxrwcm	137	32	priming	priming	NN
cord-252443-lclxrwcm	137	33	may	may	MD
cord-252443-lclxrwcm	137	34	be	be	VB
cord-252443-lclxrwcm	137	35	particularly	particularly	RB
cord-252443-lclxrwcm	137	36	important	important	JJ
cord-252443-lclxrwcm	137	37	in	in	IN
cord-252443-lclxrwcm	137	38	MVA	MVA	NNP
cord-252443-lclxrwcm	137	39	-	-	HYPH
cord-252443-lclxrwcm	137	40	mediated	mediate	VBN
cord-252443-lclxrwcm	137	41	CD8	CD8	NNP
cord-252443-lclxrwcm	137	42	+	+	CC
cord-252443-lclxrwcm	137	43	T	t	NN
cord-252443-lclxrwcm	137	44	-	-	HYPH
cord-252443-lclxrwcm	137	45	cell	cell	NN
cord-252443-lclxrwcm	137	46	responses	response	NNS
cord-252443-lclxrwcm	137	47	(	(	-LRB-
cord-252443-lclxrwcm	137	48	110	110	CD
cord-252443-lclxrwcm	137	49	,	,	,
cord-252443-lclxrwcm	137	50	114	114	CD
cord-252443-lclxrwcm	137	51	)	)	-RRB-
cord-252443-lclxrwcm	137	52	.	.	.
cord-252443-lclxrwcm	138	1	There	there	EX
cord-252443-lclxrwcm	138	2	is	be	VBZ
cord-252443-lclxrwcm	138	3	now	now	RB
cord-252443-lclxrwcm	138	4	a	a	DT
cord-252443-lclxrwcm	138	5	body	body	NN
cord-252443-lclxrwcm	138	6	of	of	IN
cord-252443-lclxrwcm	138	7	evidence	evidence	NN
cord-252443-lclxrwcm	138	8	demonstrating	demonstrate	VBG
cord-252443-lclxrwcm	138	9	that	that	IN
cord-252443-lclxrwcm	138	10	recombinant	recombinant	JJ
cord-252443-lclxrwcm	138	11	pox	pox	JJ
cord-252443-lclxrwcm	138	12	-	-	HYPH
cord-252443-lclxrwcm	138	13	viral	viral	JJ
cord-252443-lclxrwcm	138	14	vectors	vector	NNS
cord-252443-lclxrwcm	138	15	expressing	express	VBG
cord-252443-lclxrwcm	138	16	influenza	influenza	NN
cord-252443-lclxrwcm	138	17	antigens	antigen	NNS
cord-252443-lclxrwcm	138	18	are	be	VBP
cord-252443-lclxrwcm	138	19	efficacious	efficacious	JJ
cord-252443-lclxrwcm	138	20	vaccines	vaccine	NNS
cord-252443-lclxrwcm	138	21	.	.	.
cord-252443-lclxrwcm	139	1	Indeed	indeed	RB
cord-252443-lclxrwcm	139	2	,	,	,
cord-252443-lclxrwcm	139	3	there	there	EX
cord-252443-lclxrwcm	139	4	is	be	VBZ
cord-252443-lclxrwcm	139	5	a	a	DT
cord-252443-lclxrwcm	139	6	licensed	licensed	JJ
cord-252443-lclxrwcm	139	7	pox	pox	NN
cord-252443-lclxrwcm	139	8	-	-	HYPH
cord-252443-lclxrwcm	139	9	viral	viral	JJ
cord-252443-lclxrwcm	139	10	influenza	influenza	NN
cord-252443-lclxrwcm	139	11	vaccine	vaccine	NN
cord-252443-lclxrwcm	139	12	,	,	,
cord-252443-lclxrwcm	139	13	TROVAC	TROVAC	NNP
cord-252443-lclxrwcm	139	14	AIV	AIV	NNP
cord-252443-lclxrwcm	139	15	H5	H5	NNP
cord-252443-lclxrwcm	139	16	,	,	,
cord-252443-lclxrwcm	139	17	for	for	IN
cord-252443-lclxrwcm	139	18	the	the	DT
cord-252443-lclxrwcm	139	19	prevention	prevention	NN
cord-252443-lclxrwcm	139	20	of	of	IN
cord-252443-lclxrwcm	139	21	influenza	influenza	NN
cord-252443-lclxrwcm	139	22	in	in	IN
cord-252443-lclxrwcm	139	23	chickens	chicken	NNS
cord-252443-lclxrwcm	139	24	.	.	.
cord-252443-lclxrwcm	140	1	This	this	DT
cord-252443-lclxrwcm	140	2	vaccine	vaccine	NN
cord-252443-lclxrwcm	140	3	uses	use	VBZ
cord-252443-lclxrwcm	140	4	the	the	DT
cord-252443-lclxrwcm	140	5	fowlpox	fowlpox	NNP
cord-252443-lclxrwcm	140	6	virus	virus	NN
cord-252443-lclxrwcm	140	7	encoding	encode	VBG
cord-252443-lclxrwcm	140	8	the	the	DT
cord-252443-lclxrwcm	140	9	HA	HA	NNP
cord-252443-lclxrwcm	140	10	gene	gene	NN
cord-252443-lclxrwcm	140	11	from	from	IN
cord-252443-lclxrwcm	140	12	A	A	NNP
cord-252443-lclxrwcm	140	13	/	/	SYM
cord-252443-lclxrwcm	140	14	Turkey	Turkey	NNP
cord-252443-lclxrwcm	140	15	/	/	SYM
cord-252443-lclxrwcm	140	16	Ireland/83	Ireland/83	NNP
cord-252443-lclxrwcm	140	17	and	and	CC
cord-252443-lclxrwcm	140	18	has	have	VBZ
cord-252443-lclxrwcm	140	19	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	140	20	protective	protective	JJ
cord-252443-lclxrwcm	140	21	efficacy	efficacy	NN
cord-252443-lclxrwcm	140	22	against	against	IN
cord-252443-lclxrwcm	140	23	a	a	DT
cord-252443-lclxrwcm	140	24	wide	wide	JJ
cord-252443-lclxrwcm	140	25	range	range	NN
cord-252443-lclxrwcm	140	26	of	of	IN
cord-252443-lclxrwcm	140	27	highly	highly	RB
cord-252443-lclxrwcm	140	28	pathogenic	pathogenic	JJ
cord-252443-lclxrwcm	140	29	,	,	,
cord-252443-lclxrwcm	140	30	subtype	subtype	NN
cord-252443-lclxrwcm	140	31	-	-	HYPH
cord-252443-lclxrwcm	140	32	H5	h5	NN
cord-252443-lclxrwcm	140	33	viruses	virus	NNS
cord-252443-lclxrwcm	140	34	(	(	-LRB-
cord-252443-lclxrwcm	140	35	115	115	CD
cord-252443-lclxrwcm	140	36	)	)	-RRB-
cord-252443-lclxrwcm	140	37	.	.	.
cord-252443-lclxrwcm	141	1	Preclinical	preclinical	JJ
cord-252443-lclxrwcm	141	2	work	work	NN
cord-252443-lclxrwcm	141	3	has	have	VBZ
cord-252443-lclxrwcm	141	4	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	141	5	the	the	DT
cord-252443-lclxrwcm	141	6	feasibility	feasibility	NN
cord-252443-lclxrwcm	141	7	of	of	IN
cord-252443-lclxrwcm	141	8	using	use	VBG
cord-252443-lclxrwcm	141	9	MVA	MVA	NNP
cord-252443-lclxrwcm	141	10	vectored	vectore	VBN
cord-252443-lclxrwcm	141	11	influenza	influenza	NN
cord-252443-lclxrwcm	141	12	antigens	antigen	NNS
cord-252443-lclxrwcm	141	13	as	as	IN
cord-252443-lclxrwcm	141	14	vaccines	vaccine	NNS
cord-252443-lclxrwcm	141	15	in	in	IN
cord-252443-lclxrwcm	141	16	mammals	mammal	NNS
cord-252443-lclxrwcm	141	17	;	;	:
cord-252443-lclxrwcm	141	18	mice	mouse	NNS
cord-252443-lclxrwcm	141	19	vaccinated	vaccinate	VBN
cord-252443-lclxrwcm	141	20	with	with	IN
cord-252443-lclxrwcm	141	21	MVA	MVA	NNP
cord-252443-lclxrwcm	141	22	recombinants	recombinant	NNS
cord-252443-lclxrwcm	141	23	expressing	express	VBG
cord-252443-lclxrwcm	141	24	the	the	DT
cord-252443-lclxrwcm	141	25	HA	HA	NNP
cord-252443-lclxrwcm	141	26	of	of	IN
cord-252443-lclxrwcm	141	27	H5N1	H5N1	NNP
cord-252443-lclxrwcm	142	1	(	(	-LRB-
cord-252443-lclxrwcm	142	2	A	A	NNP
cord-252443-lclxrwcm	142	3	/	/	,
cord-252443-lclxrwcm	142	4	Vietnam/1194/04	vietnam/1194/04	IN
cord-252443-lclxrwcm	142	5	;	;	:
cord-252443-lclxrwcm	142	6	MVA	MVA	NNP
cord-252443-lclxrwcm	142	7	-	-	HYPH
cord-252443-lclxrwcm	142	8	HA	HA	NNP
cord-252443-lclxrwcm	142	9	-	-	HYPH
cord-252443-lclxrwcm	142	10	VN/04	VN/04	NNP
cord-252443-lclxrwcm	142	11	)	)	-RRB-
cord-252443-lclxrwcm	142	12	were	be	VBD
cord-252443-lclxrwcm	142	13	fully	fully	RB
cord-252443-lclxrwcm	142	14	protected	protect	VBN
cord-252443-lclxrwcm	142	15	against	against	IN
cord-252443-lclxrwcm	142	16	infection	infection	NN
cord-252443-lclxrwcm	142	17	with	with	IN
cord-252443-lclxrwcm	142	18	the	the	DT
cord-252443-lclxrwcm	142	19	homologous	homologous	JJ
cord-252443-lclxrwcm	142	20	strain	strain	NN
cord-252443-lclxrwcm	142	21	and	and	CC
cord-252443-lclxrwcm	142	22	also	also	RB
cord-252443-lclxrwcm	142	23	against	against	IN
cord-252443-lclxrwcm	142	24	infection	infection	NN
cord-252443-lclxrwcm	142	25	with	with	IN
cord-252443-lclxrwcm	142	26	H5	H5	NNP
cord-252443-lclxrwcm	142	27	viruses	virus	NNS
cord-252443-lclxrwcm	142	28	from	from	IN
cord-252443-lclxrwcm	142	29	different	different	JJ
cord-252443-lclxrwcm	142	30	clades	clade	NNS
cord-252443-lclxrwcm	142	31	(	(	-LRB-
cord-252443-lclxrwcm	142	32	116	116	CD
cord-252443-lclxrwcm	142	33	)	)	-RRB-
cord-252443-lclxrwcm	143	1	(	(	-LRB-
cord-252443-lclxrwcm	143	2	117	117	CD
cord-252443-lclxrwcm	143	3	)	)	-RRB-
cord-252443-lclxrwcm	144	1	(	(	-LRB-
cord-252443-lclxrwcm	144	2	118	118	CD
cord-252443-lclxrwcm	144	3	)	)	-RRB-
cord-252443-lclxrwcm	145	1	(	(	-LRB-
cord-252443-lclxrwcm	145	2	119	119	CD
cord-252443-lclxrwcm	145	3	)	)	-RRB-
cord-252443-lclxrwcm	145	4	.	.	.
cord-252443-lclxrwcm	146	1	A	a	DT
cord-252443-lclxrwcm	146	2	pentavalent	pentavalent	JJ
cord-252443-lclxrwcm	146	3	vaccina	vaccina	NN
cord-252443-lclxrwcm	146	4	vaccine	vaccine	NN
cord-252443-lclxrwcm	146	5	with	with	IN
cord-252443-lclxrwcm	146	6	HA	HA	NNP
cord-252443-lclxrwcm	146	7	,	,	,
cord-252443-lclxrwcm	146	8	NA	NA	NNP
cord-252443-lclxrwcm	146	9	,	,	,
cord-252443-lclxrwcm	146	10	nucleoprotein	nucleoprotein	NNP
cord-252443-lclxrwcm	146	11	and	and	CC
cord-252443-lclxrwcm	146	12	the	the	DT
cord-252443-lclxrwcm	146	13	matrix	matrix	NN
cord-252443-lclxrwcm	146	14	proteins	protein	NNS
cord-252443-lclxrwcm	146	15	M1	M1	NNP
cord-252443-lclxrwcm	146	16	and	and	CC
cord-252443-lclxrwcm	146	17	M2	M2	NNP
cord-252443-lclxrwcm	146	18	was	be	VBD
cord-252443-lclxrwcm	146	19	able	able	JJ
cord-252443-lclxrwcm	146	20	to	to	TO
cord-252443-lclxrwcm	146	21	confer	confer	VB
cord-252443-lclxrwcm	146	22	sterile	sterile	JJ
cord-252443-lclxrwcm	146	23	cross	cross	JJ
cord-252443-lclxrwcm	146	24	-	-	JJ
cord-252443-lclxrwcm	146	25	clade	clade	JJ
cord-252443-lclxrwcm	146	26	protection	protection	NN
cord-252443-lclxrwcm	146	27	during	during	IN
cord-252443-lclxrwcm	146	28	stringent	stringent	JJ
cord-252443-lclxrwcm	146	29	challenge	challenge	NN
cord-252443-lclxrwcm	146	30	studies	study	NNS
cord-252443-lclxrwcm	146	31	(	(	-LRB-
cord-252443-lclxrwcm	146	32	120	120	CD
cord-252443-lclxrwcm	146	33	)	)	-RRB-
cord-252443-lclxrwcm	146	34	.	.	.
cord-252443-lclxrwcm	147	1	Studies	study	NNS
cord-252443-lclxrwcm	147	2	in	in	IN
cord-252443-lclxrwcm	147	3	higher	high	JJR
cord-252443-lclxrwcm	147	4	primates	primate	NNS
cord-252443-lclxrwcm	147	5	have	have	VBP
cord-252443-lclxrwcm	147	6	assessed	assess	VBN
cord-252443-lclxrwcm	147	7	the	the	DT
cord-252443-lclxrwcm	147	8	feasibility	feasibility	NN
cord-252443-lclxrwcm	147	9	of	of	IN
cord-252443-lclxrwcm	147	10	using	use	VBG
cord-252443-lclxrwcm	147	11	MVAexpressing	mvaexpresse	VBG
cord-252443-lclxrwcm	147	12	hemagglutinin	hemagglutinin	NN
cord-252443-lclxrwcm	147	13	as	as	IN
cord-252443-lclxrwcm	147	14	an	an	DT
cord-252443-lclxrwcm	147	15	influenza	influenza	NN
cord-252443-lclxrwcm	147	16	vaccine	vaccine	NN
cord-252443-lclxrwcm	147	17	.	.	.
cord-252443-lclxrwcm	148	1	Immunization	immunization	NN
cord-252443-lclxrwcm	148	2	with	with	IN
cord-252443-lclxrwcm	148	3	A	a	NN
cord-252443-lclxrwcm	149	1	/Vietnam/	/Vietnam/	NNP
cord-252443-lclxrwcm	149	2	1194/04	1194/04	CD
cord-252443-lclxrwcm	150	1	(	(	-LRB-
cord-252443-lclxrwcm	150	2	MVA	MVA	NNP
cord-252443-lclxrwcm	150	3	-	-	HYPH
cord-252443-lclxrwcm	150	4	HA	HA	NNP
cord-252443-lclxrwcm	150	5	-	-	HYPH
cord-252443-lclxrwcm	150	6	VN/04	VN/04	NNP
cord-252443-lclxrwcm	150	7	)	)	-RRB-
cord-252443-lclxrwcm	150	8	induced	induce	VBN
cord-252443-lclxrwcm	150	9	cross	cross	JJ
cord-252443-lclxrwcm	150	10	-	-	JJ
cord-252443-lclxrwcm	150	11	reactive	reactive	JJ
cord-252443-lclxrwcm	150	12	antibodies	antibody	NNS
cord-252443-lclxrwcm	150	13	and	and	CC
cord-252443-lclxrwcm	150	14	prevented	prevent	VBD
cord-252443-lclxrwcm	150	15	virus	virus	NN
cord-252443-lclxrwcm	150	16	replication	replication	NN
cord-252443-lclxrwcm	150	17	in	in	IN
cord-252443-lclxrwcm	150	18	the	the	DT
cord-252443-lclxrwcm	150	19	respiratory	respiratory	JJ
cord-252443-lclxrwcm	150	20	tract	tract	NN
cord-252443-lclxrwcm	150	21	of	of	IN
cord-252443-lclxrwcm	150	22	cynomolgus	cynomolgus	JJ
cord-252443-lclxrwcm	150	23	macaques	macaque	NNS
cord-252443-lclxrwcm	150	24	(	(	-LRB-
cord-252443-lclxrwcm	150	25	117	117	CD
cord-252443-lclxrwcm	150	26	)	)	-RRB-
cord-252443-lclxrwcm	150	27	.	.	.
cord-252443-lclxrwcm	151	1	Indeed	indeed	RB
cord-252443-lclxrwcm	151	2	,	,	,
cord-252443-lclxrwcm	151	3	a	a	DT
cord-252443-lclxrwcm	151	4	recent	recent	JJ
cord-252443-lclxrwcm	151	5	phase	phase	NN
cord-252443-lclxrwcm	151	6	I	-PRON-	PRP
cord-252443-lclxrwcm	151	7	clinical	clinical	JJ
cord-252443-lclxrwcm	151	8	trial	trial	NN
cord-252443-lclxrwcm	151	9	assessing	assess	VBG
cord-252443-lclxrwcm	151	10	an	an	DT
cord-252443-lclxrwcm	151	11	MVA	MVA	NNP
cord-252443-lclxrwcm	151	12	vector	vector	NN
cord-252443-lclxrwcm	151	13	encoding	encode	VBG
cord-252443-lclxrwcm	151	14	nucleoprotein	nucleoprotein	NNP
cord-252443-lclxrwcm	151	15	and	and	CC
cord-252443-lclxrwcm	151	16	matrix	matrix	NN
cord-252443-lclxrwcm	151	17	protein	protein	NN
cord-252443-lclxrwcm	151	18	1	1	CD
cord-252443-lclxrwcm	151	19	(	(	-LRB-
cord-252443-lclxrwcm	151	20	MVA	MVA	NNP
cord-252443-lclxrwcm	151	21	-	-	HYPH
cord-252443-lclxrwcm	151	22	NP	NP	NNP
cord-252443-lclxrwcm	151	23	+	+	SYM
cord-252443-lclxrwcm	151	24	M1	M1	NNP
cord-252443-lclxrwcm	151	25	)	)	-RRB-
cord-252443-lclxrwcm	151	26	has	have	VBZ
cord-252443-lclxrwcm	151	27	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	151	28	that	that	IN
cord-252443-lclxrwcm	151	29	this	this	DT
cord-252443-lclxrwcm	151	30	vaccine	vaccine	NN
cord-252443-lclxrwcm	151	31	was	be	VBD
cord-252443-lclxrwcm	151	32	both	both	DT
cord-252443-lclxrwcm	151	33	safe	safe	JJ
cord-252443-lclxrwcm	151	34	and	and	CC
cord-252443-lclxrwcm	151	35	,	,	,
cord-252443-lclxrwcm	151	36	more	more	RBR
cord-252443-lclxrwcm	151	37	importantly	importantly	RB
cord-252443-lclxrwcm	151	38	,	,	,
cord-252443-lclxrwcm	151	39	immunogenic	immunogenic	JJ
cord-252443-lclxrwcm	151	40	-	-	HYPH
cord-252443-lclxrwcm	151	41	inducing	induce	VBG
cord-252443-lclxrwcm	151	42	high	high	JJ
cord-252443-lclxrwcm	151	43	levels	level	NNS
cord-252443-lclxrwcm	151	44	of	of	IN
cord-252443-lclxrwcm	151	45	interferon	interferon	NN
cord-252443-lclxrwcm	151	46	(	(	-LRB-
cord-252443-lclxrwcm	151	47	IFN)-γ	ifn)-γ	NN
cord-252443-lclxrwcm	151	48	production	production	NN
cord-252443-lclxrwcm	151	49	from	from	IN
cord-252443-lclxrwcm	151	50	T	t	NN
cord-252443-lclxrwcm	151	51	-	-	HYPH
cord-252443-lclxrwcm	151	52	cells	cell	NNS
cord-252443-lclxrwcm	151	53	(	(	-LRB-
cord-252443-lclxrwcm	151	54	75	75	CD
cord-252443-lclxrwcm	151	55	,	,	,
cord-252443-lclxrwcm	151	56	121	121	CD
cord-252443-lclxrwcm	151	57	)	)	-RRB-
cord-252443-lclxrwcm	151	58	.	.	.
cord-252443-lclxrwcm	152	1	A	a	DT
cord-252443-lclxrwcm	152	2	promising	promising	JJ
cord-252443-lclxrwcm	152	3	avenue	avenue	NN
cord-252443-lclxrwcm	152	4	of	of	IN
cord-252443-lclxrwcm	152	5	influenza	influenza	NNP
cord-252443-lclxrwcm	152	6	vaccine	vaccine	NN
cord-252443-lclxrwcm	152	7	development	development	NN
cord-252443-lclxrwcm	152	8	is	be	VBZ
cord-252443-lclxrwcm	152	9	likely	likely	JJ
cord-252443-lclxrwcm	152	10	to	to	TO
cord-252443-lclxrwcm	152	11	come	come	VB
cord-252443-lclxrwcm	152	12	from	from	IN
cord-252443-lclxrwcm	152	13	the	the	DT
cord-252443-lclxrwcm	152	14	viral	viral	JJ
cord-252443-lclxrwcm	152	15	vectored	vectore	VBN
cord-252443-lclxrwcm	152	16	vaccines	vaccine	NNS
cord-252443-lclxrwcm	152	17	currently	currently	RB
cord-252443-lclxrwcm	152	18	progressing	progress	VBG
cord-252443-lclxrwcm	152	19	through	through	IN
cord-252443-lclxrwcm	152	20	phase	phase	NN
cord-252443-lclxrwcm	152	21	I	-PRON-	PRP
cord-252443-lclxrwcm	152	22	and	and	CC
cord-252443-lclxrwcm	152	23	II	II	NNP
cord-252443-lclxrwcm	152	24	clinical	clinical	JJ
cord-252443-lclxrwcm	152	25	trials	trial	NNS
cord-252443-lclxrwcm	152	26	.	.	.
cord-252443-lclxrwcm	153	1	Designed	design	VBN
cord-252443-lclxrwcm	153	2	to	to	TO
cord-252443-lclxrwcm	153	3	produce	produce	VB
cord-252443-lclxrwcm	153	4	antiinfluenza	antiinfluenza	NNP
cord-252443-lclxrwcm	153	5	responses	response	NNS
cord-252443-lclxrwcm	153	6	,	,	,
cord-252443-lclxrwcm	153	7	these	these	DT
cord-252443-lclxrwcm	153	8	vectored	vectore	VBN
cord-252443-lclxrwcm	153	9	vaccines	vaccine	NNS
cord-252443-lclxrwcm	153	10	have	have	VBP
cord-252443-lclxrwcm	153	11	demonstrated	demonstrate	VBN
cord-252443-lclxrwcm	153	12	promising	promising	JJ
cord-252443-lclxrwcm	153	13	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	153	14	with	with	IN
cord-252443-lclxrwcm	153	15	good	good	JJ
cord-252443-lclxrwcm	153	16	safety	safety	NN
cord-252443-lclxrwcm	153	17	profiles	profile	NNS
cord-252443-lclxrwcm	153	18	and	and	CC
cord-252443-lclxrwcm	153	19	it	-PRON-	PRP
cord-252443-lclxrwcm	153	20	is	be	VBZ
cord-252443-lclxrwcm	153	21	likely	likely	JJ
cord-252443-lclxrwcm	153	22	that	that	IN
cord-252443-lclxrwcm	153	23	these	these	DT
cord-252443-lclxrwcm	153	24	vaccines	vaccine	NNS
cord-252443-lclxrwcm	153	25	will	will	MD
cord-252443-lclxrwcm	153	26	be	be	VB
cord-252443-lclxrwcm	153	27	further	further	RB
cord-252443-lclxrwcm	153	28	used	use	VBN
cord-252443-lclxrwcm	153	29	in	in	IN
cord-252443-lclxrwcm	153	30	prime	prime	JJ
cord-252443-lclxrwcm	153	31	-	-	HYPH
cord-252443-lclxrwcm	153	32	boost	boost	NN
cord-252443-lclxrwcm	153	33	regimes	regime	NNS
cord-252443-lclxrwcm	153	34	aimed	aim	VBN
cord-252443-lclxrwcm	153	35	at	at	IN
cord-252443-lclxrwcm	153	36	augmenting	augment	VBG
cord-252443-lclxrwcm	153	37	protective	protective	JJ
cord-252443-lclxrwcm	153	38	immunity	immunity	NN
cord-252443-lclxrwcm	153	39	.	.	.
cord-252443-lclxrwcm	154	1	These	these	DT
cord-252443-lclxrwcm	154	2	regimes	regime	NNS
cord-252443-lclxrwcm	154	3	involve	involve	VBP
cord-252443-lclxrwcm	154	4	priming	prime	VBG
cord-252443-lclxrwcm	154	5	the	the	DT
cord-252443-lclxrwcm	154	6	adaptive	adaptive	JJ
cord-252443-lclxrwcm	154	7	immune	immune	JJ
cord-252443-lclxrwcm	154	8	response	response	NN
cord-252443-lclxrwcm	154	9	toward	toward	IN
cord-252443-lclxrwcm	154	10	an	an	DT
cord-252443-lclxrwcm	154	11	antigenic	antigenic	JJ
cord-252443-lclxrwcm	154	12	target	target	NN
cord-252443-lclxrwcm	154	13	through	through	IN
cord-252443-lclxrwcm	154	14	vaccination	vaccination	NN
cord-252443-lclxrwcm	154	15	with	with	IN
cord-252443-lclxrwcm	154	16	a	a	DT
cord-252443-lclxrwcm	154	17	vector	vector	NN
cord-252443-lclxrwcm	154	18	encoding	encode	VBG
cord-252443-lclxrwcm	154	19	the	the	DT
cord-252443-lclxrwcm	154	20	antigen	antigen	NN
cord-252443-lclxrwcm	154	21	of	of	IN
cord-252443-lclxrwcm	154	22	choice	choice	NN
cord-252443-lclxrwcm	154	23	,	,	,
cord-252443-lclxrwcm	154	24	followed	follow	VBN
cord-252443-lclxrwcm	154	25	by	by	IN
cord-252443-lclxrwcm	154	26	a	a	DT
cord-252443-lclxrwcm	154	27	boost	boost	NN
cord-252443-lclxrwcm	154	28	,	,	,
cord-252443-lclxrwcm	154	29	in	in	IN
cord-252443-lclxrwcm	154	30	which	which	WDT
cord-252443-lclxrwcm	154	31	the	the	DT
cord-252443-lclxrwcm	154	32	same	same	JJ
cord-252443-lclxrwcm	154	33	antigenic	antigenic	JJ
cord-252443-lclxrwcm	154	34	target	target	NN
cord-252443-lclxrwcm	154	35	is	be	VBZ
cord-252443-lclxrwcm	154	36	administered	administer	VBN
cord-252443-lclxrwcm	154	37	but	but	CC
cord-252443-lclxrwcm	154	38	in	in	IN
cord-252443-lclxrwcm	154	39	a	a	DT
cord-252443-lclxrwcm	154	40	different	different	JJ
cord-252443-lclxrwcm	154	41	vector	vector	NN
cord-252443-lclxrwcm	154	42	.	.	.
cord-252443-lclxrwcm	155	1	Through	through	IN
cord-252443-lclxrwcm	155	2	this	this	DT
cord-252443-lclxrwcm	155	3	,	,	,
cord-252443-lclxrwcm	155	4	the	the	DT
cord-252443-lclxrwcm	155	5	immune	immune	JJ
cord-252443-lclxrwcm	155	6	response	response	NN
cord-252443-lclxrwcm	155	7	is	be	VBZ
cord-252443-lclxrwcm	155	8	honed	hone	VBN
cord-252443-lclxrwcm	155	9	toward	toward	IN
cord-252443-lclxrwcm	155	10	the	the	DT
cord-252443-lclxrwcm	155	11	antigen	antigen	NN
cord-252443-lclxrwcm	155	12	of	of	IN
cord-252443-lclxrwcm	155	13	choice	choice	NN
cord-252443-lclxrwcm	155	14	,	,	,
cord-252443-lclxrwcm	155	15	while	while	IN
cord-252443-lclxrwcm	155	16	avoiding	avoid	VBG
cord-252443-lclxrwcm	155	17	boosting	boost	VBG
cord-252443-lclxrwcm	155	18	antivector	antivector	NN
cord-252443-lclxrwcm	155	19	immunity	immunity	NN
cord-252443-lclxrwcm	155	20	.	.	.
cord-252443-lclxrwcm	156	1	Prime	prime	JJ
cord-252443-lclxrwcm	156	2	-	-	HYPH
cord-252443-lclxrwcm	156	3	boost	boost	NN
cord-252443-lclxrwcm	156	4	approaches	approach	NNS
cord-252443-lclxrwcm	156	5	,	,	,
cord-252443-lclxrwcm	156	6	incorporating	incorporate	VBG
cord-252443-lclxrwcm	156	7	priming	prime	VBG
cord-252443-lclxrwcm	156	8	with	with	IN
cord-252443-lclxrwcm	156	9	either	either	DT
cord-252443-lclxrwcm	156	10	plasmid	plasmid	NN
cord-252443-lclxrwcm	156	11	DNA	dna	NN
cord-252443-lclxrwcm	156	12	vaccines	vaccine	NNS
cord-252443-lclxrwcm	156	13	or	or	CC
cord-252443-lclxrwcm	156	14	viral	viral	JJ
cord-252443-lclxrwcm	156	15	vector	vector	NN
cord-252443-lclxrwcm	156	16	(	(	-LRB-
cord-252443-lclxrwcm	156	17	typically	typically	RB
cord-252443-lclxrwcm	156	18	Ad	ad	NN
cord-252443-lclxrwcm	156	19	)	)	-RRB-
cord-252443-lclxrwcm	156	20	followed	follow	VBN
cord-252443-lclxrwcm	156	21	by	by	IN
cord-252443-lclxrwcm	156	22	a	a	DT
cord-252443-lclxrwcm	156	23	boost	boost	NN
cord-252443-lclxrwcm	156	24	with	with	IN
cord-252443-lclxrwcm	156	25	either	either	CC
cord-252443-lclxrwcm	156	26	an	an	DT
cord-252443-lclxrwcm	156	27	Ad	ad	NN
cord-252443-lclxrwcm	156	28	-	-	HYPH
cord-252443-lclxrwcm	156	29	recombinant	recombinant	JJ
cord-252443-lclxrwcm	156	30	or	or	CC
cord-252443-lclxrwcm	156	31	MVA	MVA	NNP
cord-252443-lclxrwcm	156	32	expressing	express	VBG
cord-252443-lclxrwcm	156	33	the	the	DT
cord-252443-lclxrwcm	156	34	same	same	JJ
cord-252443-lclxrwcm	156	35	gene	gene	NN
cord-252443-lclxrwcm	156	36	product	product	NN
cord-252443-lclxrwcm	156	37	,	,	,
cord-252443-lclxrwcm	156	38	have	have	VBP
cord-252443-lclxrwcm	156	39	been	be	VBN
cord-252443-lclxrwcm	156	40	shown	show	VBN
cord-252443-lclxrwcm	156	41	to	to	TO
cord-252443-lclxrwcm	156	42	enhance	enhance	VB
cord-252443-lclxrwcm	156	43	protective	protective	JJ
cord-252443-lclxrwcm	156	44	efficacy	efficacy	NN
cord-252443-lclxrwcm	156	45	(	(	-LRB-
cord-252443-lclxrwcm	156	46	122	122	CD
cord-252443-lclxrwcm	156	47	,	,	,
cord-252443-lclxrwcm	156	48	123	123	CD
cord-252443-lclxrwcm	156	49	)	)	-RRB-
cord-252443-lclxrwcm	156	50	.	.	.
cord-252443-lclxrwcm	157	1	Indeed	indeed	RB
cord-252443-lclxrwcm	157	2	,	,	,
cord-252443-lclxrwcm	157	3	the	the	DT
cord-252443-lclxrwcm	157	4	use	use	NN
cord-252443-lclxrwcm	157	5	of	of	IN
cord-252443-lclxrwcm	157	6	heterologous	heterologous	JJ
cord-252443-lclxrwcm	157	7	regimens	regimen	NNS
cord-252443-lclxrwcm	157	8	with	with	IN
cord-252443-lclxrwcm	157	9	Ad	ad	NN
cord-252443-lclxrwcm	157	10	vectored	vectore	VBN
cord-252443-lclxrwcm	157	11	vaccines	vaccine	NNS
cord-252443-lclxrwcm	157	12	boosted	boost	VBN
cord-252443-lclxrwcm	157	13	with	with	IN
cord-252443-lclxrwcm	157	14	MVA	MVA	NNP
cord-252443-lclxrwcm	157	15	has	have	VBZ
cord-252443-lclxrwcm	157	16	been	be	VBN
cord-252443-lclxrwcm	157	17	shown	show	VBN
cord-252443-lclxrwcm	157	18	to	to	TO
cord-252443-lclxrwcm	157	19	augment	augment	VB
cord-252443-lclxrwcm	157	20	antigen	antigen	NN
cord-252443-lclxrwcm	157	21	-	-	HYPH
cord-252443-lclxrwcm	157	22	specific	specific	JJ
cord-252443-lclxrwcm	157	23	T	t	NN
cord-252443-lclxrwcm	157	24	-	-	HYPH
cord-252443-lclxrwcm	157	25	cell	cell	NN
cord-252443-lclxrwcm	157	26	responses	response	NNS
cord-252443-lclxrwcm	157	27	and	and	CC
cord-252443-lclxrwcm	157	28	also	also	RB
cord-252443-lclxrwcm	157	29	to	to	TO
cord-252443-lclxrwcm	157	30	efficaciously	efficaciously	RB
cord-252443-lclxrwcm	157	31	induce	induce	VB
cord-252443-lclxrwcm	157	32	humoral	humoral	JJ
cord-252443-lclxrwcm	157	33	immunity	immunity	NN
cord-252443-lclxrwcm	157	34	(	(	-LRB-
cord-252443-lclxrwcm	157	35	66	66	CD
cord-252443-lclxrwcm	157	36	,	,	,
cord-252443-lclxrwcm	157	37	(	(	-LRB-
cord-252443-lclxrwcm	157	38	124	124	CD
cord-252443-lclxrwcm	157	39	)	)	-RRB-
cord-252443-lclxrwcm	157	40	(	(	-LRB-
cord-252443-lclxrwcm	157	41	125	125	CD
cord-252443-lclxrwcm	157	42	)	)	-RRB-
cord-252443-lclxrwcm	157	43	(	(	-LRB-
cord-252443-lclxrwcm	157	44	126	126	CD
cord-252443-lclxrwcm	157	45	)	)	-RRB-
cord-252443-lclxrwcm	157	46	.	.	.
cord-252443-lclxrwcm	158	1	As	as	IN
cord-252443-lclxrwcm	158	2	the	the	DT
cord-252443-lclxrwcm	158	3	supporting	support	VBG
cord-252443-lclxrwcm	158	4	evidence	evidence	NN
cord-252443-lclxrwcm	158	5	evolves	evolve	VBZ
cord-252443-lclxrwcm	158	6	,	,	,
cord-252443-lclxrwcm	158	7	a	a	DT
cord-252443-lclxrwcm	158	8	likely	likely	JJ
cord-252443-lclxrwcm	158	9	outcome	outcome	NN
cord-252443-lclxrwcm	158	10	is	be	VBZ
cord-252443-lclxrwcm	158	11	the	the	DT
cord-252443-lclxrwcm	158	12	use	use	NN
cord-252443-lclxrwcm	158	13	of	of	IN
cord-252443-lclxrwcm	158	14	viral	viral	JJ
cord-252443-lclxrwcm	158	15	vectored	vectore	VBN
cord-252443-lclxrwcm	158	16	vaccines	vaccine	NNS
cord-252443-lclxrwcm	158	17	in	in	IN
cord-252443-lclxrwcm	158	18	prime	prime	JJ
cord-252443-lclxrwcm	158	19	-	-	HYPH
cord-252443-lclxrwcm	158	20	boost	boost	NN
cord-252443-lclxrwcm	158	21	regimes	regime	NNS
cord-252443-lclxrwcm	158	22	to	to	TO
cord-252443-lclxrwcm	158	23	generate	generate	VB
cord-252443-lclxrwcm	158	24	a	a	DT
cord-252443-lclxrwcm	158	25	strong	strong	JJ
cord-252443-lclxrwcm	158	26	and	and	CC
cord-252443-lclxrwcm	158	27	potentially	potentially	RB
cord-252443-lclxrwcm	158	28	heterosubtypic	heterosubtypic	JJ
cord-252443-lclxrwcm	158	29	immune	immune	JJ
cord-252443-lclxrwcm	158	30	response	response	NN
cord-252443-lclxrwcm	158	31	.	.	.
cord-252443-lclxrwcm	159	1	Indeed	indeed	RB
cord-252443-lclxrwcm	159	2	,	,	,
cord-252443-lclxrwcm	159	3	heterosubtypic	heterosubtypic	JJ
cord-252443-lclxrwcm	159	4	immunity	immunity	NN
cord-252443-lclxrwcm	159	5	toward	toward	IN
cord-252443-lclxrwcm	159	6	certain	certain	JJ
cord-252443-lclxrwcm	159	7	influenza	influenza	NN
cord-252443-lclxrwcm	159	8	viruses	virus	NNS
cord-252443-lclxrwcm	159	9	has	have	VBZ
cord-252443-lclxrwcm	159	10	been	be	VBN
cord-252443-lclxrwcm	159	11	induced	induce	VBN
cord-252443-lclxrwcm	159	12	through	through	IN
cord-252443-lclxrwcm	159	13	in	in	IN
cord-252443-lclxrwcm	159	14	ovo	ovo	NNP
cord-252443-lclxrwcm	159	15	vaccination	vaccination	NN
cord-252443-lclxrwcm	159	16	with	with	IN
cord-252443-lclxrwcm	159	17	a	a	DT
cord-252443-lclxrwcm	159	18	nonreplicating	nonreplicate	VBG
cord-252443-lclxrwcm	159	19	Ad	ad	NN
cord-252443-lclxrwcm	159	20	vector	vector	NN
cord-252443-lclxrwcm	159	21	expressing	express	VBG
cord-252443-lclxrwcm	159	22	HA	HA	NNP
cord-252443-lclxrwcm	159	23	from	from	IN
cord-252443-lclxrwcm	159	24	H5N9	H5N9	NNP
cord-252443-lclxrwcm	159	25	(	(	-LRB-
cord-252443-lclxrwcm	159	26	96	96	CD
cord-252443-lclxrwcm	159	27	)	)	-RRB-
cord-252443-lclxrwcm	159	28	.	.	.
cord-252443-lclxrwcm	160	1	Furthermore	furthermore	RB
cord-252443-lclxrwcm	160	2	,	,	,
cord-252443-lclxrwcm	160	3	vaccination	vaccination	NN
cord-252443-lclxrwcm	160	4	with	with	IN
cord-252443-lclxrwcm	160	5	MVA	MVA	NNP
cord-252443-lclxrwcm	160	6	recombinants	recombinant	NNS
cord-252443-lclxrwcm	160	7	expressing	express	VBG
cord-252443-lclxrwcm	160	8	the	the	DT
cord-252443-lclxrwcm	160	9	HA	HA	NNP
cord-252443-lclxrwcm	160	10	of	of	IN
cord-252443-lclxrwcm	160	11	H5N1	H5N1	NNP
cord-252443-lclxrwcm	161	1	(	(	-LRB-
cord-252443-lclxrwcm	161	2	A	A	NNP
cord-252443-lclxrwcm	161	3	/	/	,
cord-252443-lclxrwcm	161	4	Vietnam/1194/04	vietnam/1194/04	IN
cord-252443-lclxrwcm	161	5	;	;	:
cord-252443-lclxrwcm	161	6	MVA	MVA	NNP
cord-252443-lclxrwcm	161	7	-	-	HYPH
cord-252443-lclxrwcm	161	8	HA	HA	NNP
cord-252443-lclxrwcm	161	9	-	-	HYPH
cord-252443-lclxrwcm	161	10	VN/04	VN/04	NNP
cord-252443-lclxrwcm	161	11	)	)	-RRB-
cord-252443-lclxrwcm	161	12	confers	confer	VBZ
cord-252443-lclxrwcm	161	13	protection	protection	NN
cord-252443-lclxrwcm	161	14	against	against	IN
cord-252443-lclxrwcm	161	15	infection	infection	NN
cord-252443-lclxrwcm	161	16	with	with	IN
cord-252443-lclxrwcm	161	17	the	the	DT
cord-252443-lclxrwcm	161	18	homologous	homologous	JJ
cord-252443-lclxrwcm	161	19	strain	strain	NN
cord-252443-lclxrwcm	161	20	and	and	CC
cord-252443-lclxrwcm	161	21	also	also	RB
cord-252443-lclxrwcm	161	22	against	against	IN
cord-252443-lclxrwcm	161	23	H5	H5	NNP
cord-252443-lclxrwcm	161	24	viruses	virus	NNS
cord-252443-lclxrwcm	161	25	from	from	IN
cord-252443-lclxrwcm	161	26	different	different	JJ
cord-252443-lclxrwcm	161	27	clades	clade	NNS
cord-252443-lclxrwcm	161	28	(	(	-LRB-
cord-252443-lclxrwcm	161	29	116	116	CD
cord-252443-lclxrwcm	161	30	)	)	-RRB-
cord-252443-lclxrwcm	161	31	(	(	-LRB-
cord-252443-lclxrwcm	161	32	117	117	CD
cord-252443-lclxrwcm	161	33	)	)	-RRB-
cord-252443-lclxrwcm	161	34	(	(	-LRB-
cord-252443-lclxrwcm	161	35	118	118	CD
cord-252443-lclxrwcm	161	36	)	)	-RRB-
cord-252443-lclxrwcm	161	37	(	(	-LRB-
cord-252443-lclxrwcm	161	38	119	119	CD
cord-252443-lclxrwcm	161	39	)	)	-RRB-
cord-252443-lclxrwcm	161	40	.	.	.
cord-252443-lclxrwcm	162	1	The	the	DT
cord-252443-lclxrwcm	162	2	induction	induction	NN
cord-252443-lclxrwcm	162	3	of	of	IN
cord-252443-lclxrwcm	162	4	efficacious	efficacious	JJ
cord-252443-lclxrwcm	162	5	and	and	CC
cord-252443-lclxrwcm	162	6	long	long	RB
cord-252443-lclxrwcm	162	7	-	-	HYPH
cord-252443-lclxrwcm	162	8	lasting	last	VBG
cord-252443-lclxrwcm	162	9	crossclade	crossclade	NN
cord-252443-lclxrwcm	162	10	immune	immune	JJ
cord-252443-lclxrwcm	162	11	responses	response	NNS
cord-252443-lclxrwcm	162	12	will	will	MD
cord-252443-lclxrwcm	162	13	bypass	bypass	VB
cord-252443-lclxrwcm	162	14	the	the	DT
cord-252443-lclxrwcm	162	15	need	need	NN
cord-252443-lclxrwcm	162	16	for	for	IN
cord-252443-lclxrwcm	162	17	annual	annual	JJ
cord-252443-lclxrwcm	162	18	vaccine	vaccine	NN
cord-252443-lclxrwcm	162	19	reformulation	reformulation	NN
cord-252443-lclxrwcm	162	20	and	and	CC
cord-252443-lclxrwcm	162	21	immunization	immunization	NN
cord-252443-lclxrwcm	162	22	and	and	CC
cord-252443-lclxrwcm	162	23	,	,	,
cord-252443-lclxrwcm	162	24	most	most	RBS
cord-252443-lclxrwcm	162	25	importantly	importantly	RB
cord-252443-lclxrwcm	162	26	,	,	,
cord-252443-lclxrwcm	162	27	will	will	MD
cord-252443-lclxrwcm	162	28	provide	provide	VB
cord-252443-lclxrwcm	162	29	protection	protection	NN
cord-252443-lclxrwcm	162	30	during	during	IN
cord-252443-lclxrwcm	162	31	future	future	JJ
cord-252443-lclxrwcm	162	32	influenza	influenza	NN
cord-252443-lclxrwcm	162	33	pandemics	pandemic	NNS
cord-252443-lclxrwcm	162	34	.	.	.
cord-252443-lclxrwcm	163	1	Despite	despite	IN
cord-252443-lclxrwcm	163	2	the	the	DT
cord-252443-lclxrwcm	163	3	long	long	RB
cord-252443-lclxrwcm	163	4	-	-	HYPH
cord-252443-lclxrwcm	163	5	standing	stand	VBG
cord-252443-lclxrwcm	163	6	service	service	NN
cord-252443-lclxrwcm	163	7	of	of	IN
cord-252443-lclxrwcm	163	8	currently	currently	RB
cord-252443-lclxrwcm	163	9	licensed	license	VBN
cord-252443-lclxrwcm	163	10	influenza	influenza	NN
cord-252443-lclxrwcm	163	11	vaccines	vaccine	NNS
cord-252443-lclxrwcm	163	12	,	,	,
cord-252443-lclxrwcm	163	13	they	-PRON-	PRP
cord-252443-lclxrwcm	163	14	carry	carry	VBP
cord-252443-lclxrwcm	163	15	a	a	DT
cord-252443-lclxrwcm	163	16	number	number	NN
cord-252443-lclxrwcm	163	17	of	of	IN
cord-252443-lclxrwcm	163	18	real	real	JJ
cord-252443-lclxrwcm	163	19	limitations	limitation	NNS
cord-252443-lclxrwcm	163	20	that	that	WDT
cord-252443-lclxrwcm	163	21	need	need	VBP
cord-252443-lclxrwcm	163	22	to	to	TO
cord-252443-lclxrwcm	163	23	be	be	VB
cord-252443-lclxrwcm	163	24	addressed	address	VBN
cord-252443-lclxrwcm	163	25	before	before	IN
cord-252443-lclxrwcm	163	26	population	population	NN
cord-252443-lclxrwcm	163	27	-	-	HYPH
cord-252443-lclxrwcm	163	28	based	base	VBN
cord-252443-lclxrwcm	163	29	influenza	influenza	NN
cord-252443-lclxrwcm	163	30	vaccination	vaccination	NN
cord-252443-lclxrwcm	163	31	strategies	strategy	NNS
cord-252443-lclxrwcm	163	32	are	be	VBP
cord-252443-lclxrwcm	163	33	optimized	optimize	VBN
cord-252443-lclxrwcm	163	34	.	.	.
cord-252443-lclxrwcm	164	1	Undoubtedly	undoubtedly	RB
cord-252443-lclxrwcm	164	2	,	,	,
cord-252443-lclxrwcm	164	3	a	a	DT
cord-252443-lclxrwcm	164	4	vaccine	vaccine	NN
cord-252443-lclxrwcm	164	5	that	that	WDT
cord-252443-lclxrwcm	164	6	induced	induce	VBD
cord-252443-lclxrwcm	164	7	durable	durable	JJ
cord-252443-lclxrwcm	164	8	,	,	,
cord-252443-lclxrwcm	164	9	sustainable	sustainable	JJ
cord-252443-lclxrwcm	164	10	and	and	CC
cord-252443-lclxrwcm	164	11	cross	cross	JJ
cord-252443-lclxrwcm	164	12	-	-	JJ
cord-252443-lclxrwcm	164	13	clade	clade	JJ
cord-252443-lclxrwcm	164	14	protection	protection	NN
cord-252443-lclxrwcm	164	15	against	against	IN
cord-252443-lclxrwcm	164	16	influenza	influenza	NN
cord-252443-lclxrwcm	164	17	would	would	MD
cord-252443-lclxrwcm	164	18	be	be	VB
cord-252443-lclxrwcm	164	19	of	of	IN
cord-252443-lclxrwcm	164	20	great	great	JJ
cord-252443-lclxrwcm	164	21	medicinal	medicinal	JJ
cord-252443-lclxrwcm	164	22	and	and	CC
cord-252443-lclxrwcm	164	23	economic	economic	JJ
cord-252443-lclxrwcm	164	24	benefit	benefit	NN
cord-252443-lclxrwcm	164	25	worldwide	worldwide	RB
cord-252443-lclxrwcm	164	26	.	.	.
cord-252443-lclxrwcm	165	1	At	at	IN
cord-252443-lclxrwcm	165	2	the	the	DT
cord-252443-lclxrwcm	165	3	very	very	JJ
cord-252443-lclxrwcm	165	4	minimum	minimum	NN
cord-252443-lclxrwcm	165	5	,	,	,
cord-252443-lclxrwcm	165	6	a	a	DT
cord-252443-lclxrwcm	165	7	revision	revision	NN
cord-252443-lclxrwcm	165	8	of	of	IN
cord-252443-lclxrwcm	165	9	the	the	DT
cord-252443-lclxrwcm	165	10	current	current	JJ
cord-252443-lclxrwcm	165	11	vaccine	vaccine	NN
cord-252443-lclxrwcm	165	12	regimes	regime	NNS
cord-252443-lclxrwcm	165	13	for	for	IN
cord-252443-lclxrwcm	165	14	at	at	IN
cord-252443-lclxrwcm	165	15	-	-	HYPH
cord-252443-lclxrwcm	165	16	risk	risk	NN
cord-252443-lclxrwcm	165	17	populations	population	NNS
cord-252443-lclxrwcm	165	18	needs	need	VBZ
cord-252443-lclxrwcm	165	19	to	to	TO
cord-252443-lclxrwcm	165	20	be	be	VB
cord-252443-lclxrwcm	165	21	considered	consider	VBN
cord-252443-lclxrwcm	165	22	to	to	TO
cord-252443-lclxrwcm	165	23	optimize	optimize	VB
cord-252443-lclxrwcm	165	24	health	health	NN
cord-252443-lclxrwcm	165	25	outcomes	outcome	NNS
cord-252443-lclxrwcm	165	26	.	.	.
cord-252443-lclxrwcm	166	1	An	an	DT
cord-252443-lclxrwcm	166	2	improved	improved	JJ
cord-252443-lclxrwcm	166	3	regime	regime	NN
cord-252443-lclxrwcm	166	4	is	be	VBZ
cord-252443-lclxrwcm	166	5	likely	likely	JJ
cord-252443-lclxrwcm	166	6	to	to	TO
cord-252443-lclxrwcm	166	7	include	include	VB
cord-252443-lclxrwcm	166	8	different	different	JJ
cord-252443-lclxrwcm	166	9	vaccines	vaccine	NNS
cord-252443-lclxrwcm	166	10	for	for	IN
cord-252443-lclxrwcm	166	11	the	the	DT
cord-252443-lclxrwcm	166	12	different	different	JJ
cord-252443-lclxrwcm	166	13	ages	age	NNS
cord-252443-lclxrwcm	166	14	of	of	IN
cord-252443-lclxrwcm	166	15	man	man	NN
cord-252443-lclxrwcm	166	16	:	:	:
cord-252443-lclxrwcm	166	17	for	for	IN
cord-252443-lclxrwcm	166	18	children	child	NNS
cord-252443-lclxrwcm	166	19	,	,	,
cord-252443-lclxrwcm	166	20	a	a	DT
cord-252443-lclxrwcm	166	21	fourpronged	fourpronged	JJ
cord-252443-lclxrwcm	166	22	approach	approach	NN
cord-252443-lclxrwcm	166	23	including	include	VBG
cord-252443-lclxrwcm	166	24	the	the	DT
cord-252443-lclxrwcm	166	25	two	two	CD
cord-252443-lclxrwcm	166	26	currently	currently	RB
cord-252443-lclxrwcm	166	27	circulating	circulate	VBG
cord-252443-lclxrwcm	166	28	influenza	influenza	NN
cord-252443-lclxrwcm	166	29	A	a	DT
cord-252443-lclxrwcm	166	30	subtypes	subtype	NNS
cord-252443-lclxrwcm	166	31	and	and	CC
cord-252443-lclxrwcm	166	32	both	both	DT
cord-252443-lclxrwcm	166	33	influenza	influenza	NN
cord-252443-lclxrwcm	166	34	B	b	NN
cord-252443-lclxrwcm	166	35	strains	strain	NNS
cord-252443-lclxrwcm	166	36	has	have	VBZ
cord-252443-lclxrwcm	166	37	been	be	VBN
cord-252443-lclxrwcm	166	38	suggested	suggest	VBN
cord-252443-lclxrwcm	166	39	(	(	-LRB-
cord-252443-lclxrwcm	166	40	11	11	CD
cord-252443-lclxrwcm	166	41	)	)	-RRB-
cord-252443-lclxrwcm	166	42	.	.	.
cord-252443-lclxrwcm	167	1	Whereas	whereas	IN
cord-252443-lclxrwcm	167	2	for	for	IN
cord-252443-lclxrwcm	167	3	the	the	DT
cord-252443-lclxrwcm	167	4	elderly	elderly	JJ
cord-252443-lclxrwcm	167	5	,	,	,
cord-252443-lclxrwcm	167	6	inclusion	inclusion	NN
cord-252443-lclxrwcm	167	7	of	of	IN
cord-252443-lclxrwcm	167	8	the	the	DT
cord-252443-lclxrwcm	167	9	two	two	CD
cord-252443-lclxrwcm	167	10	currently	currently	RB
cord-252443-lclxrwcm	167	11	circulating	circulate	VBG
cord-252443-lclxrwcm	167	12	influenza	influenza	NN
cord-252443-lclxrwcm	167	13	A	a	DT
cord-252443-lclxrwcm	167	14	subtypes	subtype	NNS
cord-252443-lclxrwcm	167	15	and	and	CC
cord-252443-lclxrwcm	167	16	both	both	DT
cord-252443-lclxrwcm	167	17	influenza	influenza	NN
cord-252443-lclxrwcm	167	18	B	b	IN
cord-252443-lclxrwcm	167	19	strains	strain	NNS
cord-252443-lclxrwcm	167	20	at	at	IN
cord-252443-lclxrwcm	167	21	a	a	DT
cord-252443-lclxrwcm	167	22	higher	high	JJR
cord-252443-lclxrwcm	167	23	dose	dose	NN
cord-252443-lclxrwcm	167	24	or	or	CC
cord-252443-lclxrwcm	167	25	the	the	DT
cord-252443-lclxrwcm	167	26	inclusion	inclusion	NN
cord-252443-lclxrwcm	167	27	of	of	IN
cord-252443-lclxrwcm	167	28	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	167	29	to	to	TO
cord-252443-lclxrwcm	167	30	augment	augment	VB
cord-252443-lclxrwcm	167	31	the	the	DT
cord-252443-lclxrwcm	167	32	lower	low	JJR
cord-252443-lclxrwcm	167	33	responses	response	NNS
cord-252443-lclxrwcm	167	34	should	should	MD
cord-252443-lclxrwcm	167	35	be	be	VB
cord-252443-lclxrwcm	167	36	considered	consider	VBN
cord-252443-lclxrwcm	167	37	.	.	.
cord-252443-lclxrwcm	168	1	Undoubtedly	undoubtedly	RB
cord-252443-lclxrwcm	168	2	,	,	,
cord-252443-lclxrwcm	168	3	the	the	DT
cord-252443-lclxrwcm	168	4	continued	continued	JJ
cord-252443-lclxrwcm	168	5	and	and	CC
cord-252443-lclxrwcm	168	6	concerted	concerted	JJ
cord-252443-lclxrwcm	168	7	effort	effort	NN
cord-252443-lclxrwcm	168	8	invested	invest	VBN
cord-252443-lclxrwcm	168	9	in	in	IN
cord-252443-lclxrwcm	168	10	developing	develop	VBG
cord-252443-lclxrwcm	168	11	efficacious	efficacious	JJ
cord-252443-lclxrwcm	168	12	viral	viral	JJ
cord-252443-lclxrwcm	168	13	vectored	vectore	VBN
cord-252443-lclxrwcm	168	14	influenza	influenza	NN
cord-252443-lclxrwcm	168	15	vaccines	vaccine	NNS
cord-252443-lclxrwcm	168	16	will	will	MD
cord-252443-lclxrwcm	168	17	deliver	deliver	VB
cord-252443-lclxrwcm	168	18	promising	promising	JJ
cord-252443-lclxrwcm	168	19	and	and	CC
cord-252443-lclxrwcm	168	20	real	real	JJ
cord-252443-lclxrwcm	168	21	alternatives	alternative	NNS
cord-252443-lclxrwcm	168	22	to	to	IN
cord-252443-lclxrwcm	168	23	those	those	DT
cord-252443-lclxrwcm	168	24	currently	currently	RB
cord-252443-lclxrwcm	168	25	deployed	deploy	VBN
cord-252443-lclxrwcm	168	26	and	and	CC
cord-252443-lclxrwcm	168	27	greatly	greatly	RB
cord-252443-lclxrwcm	168	28	impact	impact	NN
cord-252443-lclxrwcm	168	29	upon	upon	IN
cord-252443-lclxrwcm	168	30	public	public	JJ
cord-252443-lclxrwcm	168	31	health	health	NN
cord-252443-lclxrwcm	168	32	in	in	IN
cord-252443-lclxrwcm	168	33	the	the	DT
cord-252443-lclxrwcm	168	34	21st	21st	JJ
cord-252443-lclxrwcm	168	35	century	century	NN
cord-252443-lclxrwcm	168	36	.	.	.
cord-252443-lclxrwcm	169	1	T	T	NNP
cord-252443-lclxrwcm	169	2	Lambe	Lambe	NNP
cord-252443-lclxrwcm	169	3	is	be	VBZ
cord-252443-lclxrwcm	169	4	an	an	DT
cord-252443-lclxrwcm	169	5	Oxford	Oxford	NNP
cord-252443-lclxrwcm	169	6	Martin	Martin	NNP
cord-252443-lclxrwcm	169	7	Fellow	Fellow	NNP
cord-252443-lclxrwcm	169	8	and	and	CC
cord-252443-lclxrwcm	169	9	receives	receive	VBZ
cord-252443-lclxrwcm	169	10	financial	financial	JJ
cord-252443-lclxrwcm	169	11	support	support	NN
cord-252443-lclxrwcm	169	12	from	from	IN
cord-252443-lclxrwcm	169	13	the	the	DT
cord-252443-lclxrwcm	169	14	Medical	Medical	NNP
cord-252443-lclxrwcm	169	15	Research	Research	NNP
cord-252443-lclxrwcm	169	16	Council	Council	NNP
cord-252443-lclxrwcm	169	17	,	,	,
cord-252443-lclxrwcm	169	18	UK	UK	NNP
cord-252443-lclxrwcm	169	19	,	,	,
cord-252443-lclxrwcm	169	20	and	and	CC
cord-252443-lclxrwcm	169	21	the	the	DT
cord-252443-lclxrwcm	169	22	Oxford	Oxford	NNP
cord-252443-lclxrwcm	169	23	Biomedical	Biomedical	NNP
cord-252443-lclxrwcm	169	24	Research	Research	NNP
cord-252443-lclxrwcm	169	25	Centre	Centre	NNP
cord-252443-lclxrwcm	169	26	.	.	.
cord-252443-lclxrwcm	170	1	The	the	DT
cord-252443-lclxrwcm	170	2	author	author	NN
cord-252443-lclxrwcm	170	3	is	be	VBZ
cord-252443-lclxrwcm	170	4	grateful	grateful	JJ
cord-252443-lclxrwcm	170	5	to	to	IN
cord-252443-lclxrwcm	170	6	S	S	NNP
cord-252443-lclxrwcm	170	7	Gilbert	Gilbert	NNP
cord-252443-lclxrwcm	170	8	and	and	CC
cord-252443-lclxrwcm	170	9	R	R	NNP
cord-252443-lclxrwcm	170	10	O'Donnell	O'Donnell	NNP
cord-252443-lclxrwcm	170	11	for	for	IN
cord-252443-lclxrwcm	170	12	their	-PRON-	PRP$
cord-252443-lclxrwcm	170	13	helpful	helpful	JJ
cord-252443-lclxrwcm	170	14	comments	comment	NNS
cord-252443-lclxrwcm	170	15	on	on	IN
cord-252443-lclxrwcm	170	16	the	the	DT
cord-252443-lclxrwcm	170	17	manuscript	manuscript	NN
cord-252443-lclxrwcm	170	18	.	.	.
cord-252443-lclxrwcm	171	1	The	the	DT
cord-252443-lclxrwcm	171	2	authors	author	NNS
cord-252443-lclxrwcm	171	3	declare	declare	VBP
cord-252443-lclxrwcm	171	4	that	that	IN
cord-252443-lclxrwcm	171	5	they	-PRON-	PRP
cord-252443-lclxrwcm	171	6	have	have	VBP
cord-252443-lclxrwcm	171	7	no	no	DT
cord-252443-lclxrwcm	171	8	competing	compete	VBG
cord-252443-lclxrwcm	171	9	interests	interest	NNS
cord-252443-lclxrwcm	171	10	as	as	IN
cord-252443-lclxrwcm	171	11	defined	define	VBN
cord-252443-lclxrwcm	171	12	by	by	IN
cord-252443-lclxrwcm	171	13	Molecular	Molecular	NNP
cord-252443-lclxrwcm	171	14	Medicine	Medicine	NNP
cord-252443-lclxrwcm	171	15	,	,	,
cord-252443-lclxrwcm	171	16	or	or	CC
cord-252443-lclxrwcm	171	17	other	other	JJ
cord-252443-lclxrwcm	171	18	interests	interest	NNS
cord-252443-lclxrwcm	171	19	that	that	WDT
cord-252443-lclxrwcm	171	20	might	may	MD
cord-252443-lclxrwcm	171	21	be	be	VB
cord-252443-lclxrwcm	171	22	perceived	perceive	VBN
cord-252443-lclxrwcm	171	23	to	to	TO
cord-252443-lclxrwcm	171	24	influence	influence	VB
cord-252443-lclxrwcm	171	25	the	the	DT
cord-252443-lclxrwcm	171	26	results	result	NNS
cord-252443-lclxrwcm	171	27	and	and	CC
cord-252443-lclxrwcm	171	28	discussion	discussion	NN
cord-252443-lclxrwcm	171	29	reported	report	VBN
cord-252443-lclxrwcm	171	30	in	in	IN
cord-252443-lclxrwcm	171	31	this	this	DT
cord-252443-lclxrwcm	171	32	paper	paper	NN
cord-252443-lclxrwcm	171	33	.	.	.
cord-252443-lclxrwcm	172	1	The	the	DT
cord-252443-lclxrwcm	172	2	annual	annual	JJ
cord-252443-lclxrwcm	172	3	impact	impact	NN
cord-252443-lclxrwcm	172	4	of	of	IN
cord-252443-lclxrwcm	172	5	seasonal	seasonal	JJ
cord-252443-lclxrwcm	172	6	influenza	influenza	NN
cord-252443-lclxrwcm	172	7	in	in	IN
cord-252443-lclxrwcm	172	8	the	the	DT
cord-252443-lclxrwcm	172	9	US	US	NNP
cord-252443-lclxrwcm	172	10	:	:	:
cord-252443-lclxrwcm	172	11	measuring	measure	VBG
cord-252443-lclxrwcm	172	12	disease	disease	NN
cord-252443-lclxrwcm	172	13	burden	burden	NN
cord-252443-lclxrwcm	172	14	and	and	CC
cord-252443-lclxrwcm	172	15	costs	cost	VBZ
cord-252443-lclxrwcm	172	16	Influenza	influenza	NN
cord-252443-lclxrwcm	172	17	vaccines	vaccine	NNS
cord-252443-lclxrwcm	172	18	for	for	IN
cord-252443-lclxrwcm	172	19	the	the	DT
cord-252443-lclxrwcm	172	20	future	future	NN
cord-252443-lclxrwcm	172	21	Updating	update	VBG
cord-252443-lclxrwcm	172	22	the	the	DT
cord-252443-lclxrwcm	172	23	accounts	account	NNS
cord-252443-lclxrwcm	172	24	:	:	:
cord-252443-lclxrwcm	172	25	global	global	JJ
cord-252443-lclxrwcm	172	26	mortality	mortality	NN
cord-252443-lclxrwcm	172	27	of	of	IN
cord-252443-lclxrwcm	172	28	the	the	DT
cord-252443-lclxrwcm	172	29	1918	1918	CD
cord-252443-lclxrwcm	172	30	-	-	SYM
cord-252443-lclxrwcm	172	31	1920	1920	CD
cord-252443-lclxrwcm	172	32	"	"	``
cord-252443-lclxrwcm	172	33	Spanish	spanish	JJ
cord-252443-lclxrwcm	172	34	"	"	''
cord-252443-lclxrwcm	172	35	influenza	influenza	NN
cord-252443-lclxrwcm	172	36	pandemic	pandemic	NN
cord-252443-lclxrwcm	172	37	Avian	avian	JJ
cord-252443-lclxrwcm	172	38	influenza	influenza	NN
cord-252443-lclxrwcm	172	39	.	.	.
cord-252443-lclxrwcm	173	1	Warning	warning	NN
cord-252443-lclxrwcm	173	2	of	of	IN
cord-252443-lclxrwcm	173	3	H5N1	H5N1	NNP
cord-252443-lclxrwcm	173	4	resurgence	resurgence	NN
cord-252443-lclxrwcm	173	5	surprises	surprise	VBZ
cord-252443-lclxrwcm	173	6	community	community	NN
cord-252443-lclxrwcm	173	7	Sequence	sequence	NN
cord-252443-lclxrwcm	173	8	similarities	similarity	NNS
cord-252443-lclxrwcm	173	9	and	and	CC
cord-252443-lclxrwcm	173	10	evolutionary	evolutionary	JJ
cord-252443-lclxrwcm	173	11	relationships	relationship	NNS
cord-252443-lclxrwcm	173	12	of	of	IN
cord-252443-lclxrwcm	173	13	influenza	influenza	NN
cord-252443-lclxrwcm	173	14	virus	virus	NN
cord-252443-lclxrwcm	174	1	A	a	DT
cord-252443-lclxrwcm	174	2	hemagglutinins	hemagglutinins	NNP
cord-252443-lclxrwcm	174	3	Influenza	Influenza	NNP
cord-252443-lclxrwcm	174	4	hemagglutinin	hemagglutinin	NN
cord-252443-lclxrwcm	174	5	and	and	CC
cord-252443-lclxrwcm	174	6	neuraminidase	neuraminidase	NN
cord-252443-lclxrwcm	174	7	membrane	membrane	NN
cord-252443-lclxrwcm	174	8	glycoproteins	glycoprotein	NNS
cord-252443-lclxrwcm	175	1	A	a	DT
cord-252443-lclxrwcm	175	2	distinct	distinct	JJ
cord-252443-lclxrwcm	175	3	lineage	lineage	NN
cord-252443-lclxrwcm	175	4	of	of	IN
cord-252443-lclxrwcm	175	5	influenza	influenza	NN
cord-252443-lclxrwcm	175	6	A	a	DT
cord-252443-lclxrwcm	175	7	virus	virus	NN
cord-252443-lclxrwcm	175	8	from	from	IN
cord-252443-lclxrwcm	175	9	bats	bat	NNS
cord-252443-lclxrwcm	175	10	Influenza	Influenza	NNP
cord-252443-lclxrwcm	175	11	pandemics	pandemic	NNS
cord-252443-lclxrwcm	175	12	Influenza	Influenza	NNP
cord-252443-lclxrwcm	175	13	B	B	NNP
cord-252443-lclxrwcm	175	14	virus	virus	NN
cord-252443-lclxrwcm	175	15	evolution	evolution	NN
cord-252443-lclxrwcm	175	16	:	:	:
cord-252443-lclxrwcm	175	17	co	co	NN
cord-252443-lclxrwcm	175	18	-	-	JJ
cord-252443-lclxrwcm	175	19	circulating	circulate	VBG
cord-252443-lclxrwcm	175	20	lineages	lineage	NNS
cord-252443-lclxrwcm	175	21	and	and	CC
cord-252443-lclxrwcm	175	22	comparison	comparison	NN
cord-252443-lclxrwcm	175	23	of	of	IN
cord-252443-lclxrwcm	175	24	evolutionary	evolutionary	JJ
cord-252443-lclxrwcm	175	25	pattern	pattern	NN
cord-252443-lclxrwcm	175	26	with	with	IN
cord-252443-lclxrwcm	175	27	those	those	DT
cord-252443-lclxrwcm	175	28	of	of	IN
cord-252443-lclxrwcm	175	29	influenza	influenza	NN
cord-252443-lclxrwcm	175	30	A	a	NN
cord-252443-lclxrwcm	175	31	and	and	CC
cord-252443-lclxrwcm	175	32	C	c	NN
cord-252443-lclxrwcm	175	33	viruses	virus	NNS
cord-252443-lclxrwcm	175	34	Clinical	clinical	JJ
cord-252443-lclxrwcm	175	35	and	and	CC
cord-252443-lclxrwcm	175	36	genetic	genetic	JJ
cord-252443-lclxrwcm	175	37	characterization	characterization	NN
cord-252443-lclxrwcm	175	38	of	of	IN
cord-252443-lclxrwcm	175	39	severe	severe	JJ
cord-252443-lclxrwcm	175	40	influenza	influenza	NN
cord-252443-lclxrwcm	175	41	B	b	NN
cord-252443-lclxrwcm	175	42	-	-	HYPH
cord-252443-lclxrwcm	175	43	associated	associate	VBN
cord-252443-lclxrwcm	175	44	diseases	disease	NNS
cord-252443-lclxrwcm	175	45	during	during	IN
cord-252443-lclxrwcm	175	46	an	an	DT
cord-252443-lclxrwcm	175	47	outbreak	outbreak	NN
cord-252443-lclxrwcm	175	48	in	in	IN
cord-252443-lclxrwcm	175	49	Taiwan	Taiwan	NNP
cord-252443-lclxrwcm	176	1	The	the	DT
cord-252443-lclxrwcm	176	2	need	need	NN
cord-252443-lclxrwcm	176	3	for	for	IN
cord-252443-lclxrwcm	176	4	quadrivalent	quadrivalent	NN
cord-252443-lclxrwcm	176	5	vaccine	vaccine	NN
cord-252443-lclxrwcm	176	6	against	against	IN
cord-252443-lclxrwcm	176	7	seasonal	seasonal	JJ
cord-252443-lclxrwcm	176	8	influenza	influenza	NN
cord-252443-lclxrwcm	176	9	Clinical	clinical	JJ
cord-252443-lclxrwcm	176	10	features	feature	NNS
cord-252443-lclxrwcm	176	11	of	of	IN
cord-252443-lclxrwcm	176	12	influenza	influenza	NN
cord-252443-lclxrwcm	176	13	C	c	NN
cord-252443-lclxrwcm	176	14	virus	virus	NN
cord-252443-lclxrwcm	176	15	infection	infection	NN
cord-252443-lclxrwcm	176	16	in	in	IN
cord-252443-lclxrwcm	176	17	children	child	NNS
cord-252443-lclxrwcm	176	18	Mortality	mortality	NN
cord-252443-lclxrwcm	176	19	associated	associate	VBN
cord-252443-lclxrwcm	176	20	with	with	IN
cord-252443-lclxrwcm	176	21	influenza	influenza	NN
cord-252443-lclxrwcm	176	22	and	and	CC
cord-252443-lclxrwcm	176	23	respiratory	respiratory	JJ
cord-252443-lclxrwcm	176	24	syncytial	syncytial	JJ
cord-252443-lclxrwcm	176	25	virus	virus	NN
cord-252443-lclxrwcm	176	26	in	in	IN
cord-252443-lclxrwcm	176	27	the	the	DT
cord-252443-lclxrwcm	176	28	United	United	NNP
cord-252443-lclxrwcm	176	29	States	States	NNP
cord-252443-lclxrwcm	176	30	Global	Global	NNP
cord-252443-lclxrwcm	176	31	burden	burden	NN
cord-252443-lclxrwcm	176	32	of	of	IN
cord-252443-lclxrwcm	176	33	respiratory	respiratory	JJ
cord-252443-lclxrwcm	176	34	infections	infection	NNS
cord-252443-lclxrwcm	176	35	due	due	JJ
cord-252443-lclxrwcm	176	36	to	to	IN
cord-252443-lclxrwcm	176	37	seasonal	seasonal	JJ
cord-252443-lclxrwcm	176	38	influenza	influenza	NN
cord-252443-lclxrwcm	176	39	in	in	IN
cord-252443-lclxrwcm	176	40	young	young	JJ
cord-252443-lclxrwcm	176	41	children	child	NNS
cord-252443-lclxrwcm	176	42	:	:	:
cord-252443-lclxrwcm	176	43	a	a	DT
cord-252443-lclxrwcm	176	44	systematic	systematic	JJ
cord-252443-lclxrwcm	176	45	review	review	NN
cord-252443-lclxrwcm	176	46	and	and	CC
cord-252443-lclxrwcm	176	47	meta	meta	NNP
cord-252443-lclxrwcm	176	48	-	-	HYPH
cord-252443-lclxrwcm	176	49	analysis	analysis	NN
cord-252443-lclxrwcm	176	50	Should	Should	MD
cord-252443-lclxrwcm	176	51	healthy	healthy	JJ
cord-252443-lclxrwcm	176	52	children	child	NNS
cord-252443-lclxrwcm	176	53	be	be	VB
cord-252443-lclxrwcm	176	54	vaccinated	vaccinate	VBN
cord-252443-lclxrwcm	176	55	against	against	IN
cord-252443-lclxrwcm	176	56	influenza	influenza	NN
cord-252443-lclxrwcm	176	57	?	?	.
cord-252443-lclxrwcm	177	1	A	a	DT
cord-252443-lclxrwcm	177	2	consensus	consensus	NN
cord-252443-lclxrwcm	177	3	report	report	NN
cord-252443-lclxrwcm	177	4	of	of	IN
cord-252443-lclxrwcm	177	5	the	the	DT
cord-252443-lclxrwcm	177	6	Summits	Summits	NNPS
cord-252443-lclxrwcm	177	7	of	of	IN
cord-252443-lclxrwcm	177	8	Independent	Independent	NNP
cord-252443-lclxrwcm	177	9	European	european	JJ
cord-252443-lclxrwcm	177	10	Vaccination	Vaccination	NNP
cord-252443-lclxrwcm	177	11	Experts	expert	NNS
cord-252443-lclxrwcm	178	1	The	the	DT
cord-252443-lclxrwcm	178	2	Japanese	japanese	JJ
cord-252443-lclxrwcm	178	3	experience	experience	NN
cord-252443-lclxrwcm	178	4	with	with	IN
cord-252443-lclxrwcm	178	5	vaccinating	vaccinate	VBG
cord-252443-lclxrwcm	178	6	schoolchildren	schoolchildren	NNS
cord-252443-lclxrwcm	178	7	against	against	IN
cord-252443-lclxrwcm	178	8	influenza	influenza	NN
cord-252443-lclxrwcm	178	9	Should	Should	MD
cord-252443-lclxrwcm	178	10	healthy	healthy	JJ
cord-252443-lclxrwcm	178	11	children	child	NNS
cord-252443-lclxrwcm	178	12	be	be	VB
cord-252443-lclxrwcm	178	13	vaccinated	vaccinate	VBN
cord-252443-lclxrwcm	178	14	against	against	IN
cord-252443-lclxrwcm	178	15	influenza	influenza	NN
cord-252443-lclxrwcm	178	16	?	?	.
cord-252443-lclxrwcm	179	1	Comments	comment	NNS
cord-252443-lclxrwcm	179	2	about	about	IN
cord-252443-lclxrwcm	179	3	this	this	DT
cord-252443-lclxrwcm	179	4	query	query	NN
cord-252443-lclxrwcm	179	5	Association	Association	NNP
cord-252443-lclxrwcm	179	6	between	between	IN
cord-252443-lclxrwcm	179	7	the	the	DT
cord-252443-lclxrwcm	179	8	2008	2008	CD
cord-252443-lclxrwcm	179	9	-	-	SYM
cord-252443-lclxrwcm	179	10	09	09	CD
cord-252443-lclxrwcm	179	11	seasonal	seasonal	JJ
cord-252443-lclxrwcm	179	12	influenza	influenza	NN
cord-252443-lclxrwcm	179	13	vaccine	vaccine	NN
cord-252443-lclxrwcm	179	14	and	and	CC
cord-252443-lclxrwcm	179	15	pandemic	pandemic	NN
cord-252443-lclxrwcm	179	16	H1N1	H1N1	NNP
cord-252443-lclxrwcm	179	17	illness	illness	NN
cord-252443-lclxrwcm	179	18	during	during	IN
cord-252443-lclxrwcm	179	19	Spring	Spring	NNP
cord-252443-lclxrwcm	179	20	-	-	HYPH
cord-252443-lclxrwcm	179	21	Summer	Summer	NNP
cord-252443-lclxrwcm	179	22	2009	2009	CD
cord-252443-lclxrwcm	179	23	:	:	:
cord-252443-lclxrwcm	180	1	four	four	CD
cord-252443-lclxrwcm	180	2	observational	observational	JJ
cord-252443-lclxrwcm	180	3	studies	study	NNS
cord-252443-lclxrwcm	180	4	from	from	IN
cord-252443-lclxrwcm	180	5	Canada	Canada	NNP
cord-252443-lclxrwcm	180	6	Reduced	reduce	VBN
cord-252443-lclxrwcm	180	7	antibody	antibody	NN
cord-252443-lclxrwcm	180	8	responses	response	NNS
cord-252443-lclxrwcm	180	9	to	to	IN
cord-252443-lclxrwcm	180	10	the	the	DT
cord-252443-lclxrwcm	180	11	pandemic	pandemic	NN
cord-252443-lclxrwcm	180	12	(	(	-LRB-
cord-252443-lclxrwcm	180	13	H1N1	H1N1	NNP
cord-252443-lclxrwcm	180	14	)	)	-RRB-
cord-252443-lclxrwcm	180	15	2009	2009	CD
cord-252443-lclxrwcm	180	16	vaccine	vaccine	NN
cord-252443-lclxrwcm	180	17	after	after	IN
cord-252443-lclxrwcm	180	18	recent	recent	JJ
cord-252443-lclxrwcm	180	19	seasonal	seasonal	JJ
cord-252443-lclxrwcm	180	20	influenza	influenza	NN
cord-252443-lclxrwcm	180	21	vaccination	vaccination	NN
cord-252443-lclxrwcm	180	22	Immunogenicity	Immunogenicity	NNP
cord-252443-lclxrwcm	180	23	,	,	,
cord-252443-lclxrwcm	180	24	boostability	boostability	NN
cord-252443-lclxrwcm	180	25	,	,	,
cord-252443-lclxrwcm	180	26	and	and	CC
cord-252443-lclxrwcm	180	27	sustainability	sustainability	NN
cord-252443-lclxrwcm	180	28	of	of	IN
cord-252443-lclxrwcm	180	29	the	the	DT
cord-252443-lclxrwcm	180	30	immune	immune	JJ
cord-252443-lclxrwcm	180	31	response	response	NN
cord-252443-lclxrwcm	180	32	after	after	IN
cord-252443-lclxrwcm	180	33	vaccination	vaccination	NN
cord-252443-lclxrwcm	180	34	against	against	IN
cord-252443-lclxrwcm	180	35	Influenza	Influenza	NNP
cord-252443-lclxrwcm	180	36	A	a	DT
cord-252443-lclxrwcm	180	37	virus	virus	NN
cord-252443-lclxrwcm	180	38	(	(	-LRB-
cord-252443-lclxrwcm	180	39	H1N1	H1N1	NNP
cord-252443-lclxrwcm	180	40	)	)	-RRB-
cord-252443-lclxrwcm	180	41	2009	2009	CD
cord-252443-lclxrwcm	180	42	in	in	IN
cord-252443-lclxrwcm	180	43	a	a	DT
cord-252443-lclxrwcm	180	44	healthy	healthy	JJ
cord-252443-lclxrwcm	180	45	population	population	NN
cord-252443-lclxrwcm	180	46	Protective	protective	JJ
cord-252443-lclxrwcm	180	47	efficacy	efficacy	NN
cord-252443-lclxrwcm	180	48	of	of	IN
cord-252443-lclxrwcm	180	49	seasonal	seasonal	JJ
cord-252443-lclxrwcm	180	50	influenza	influenza	NN
cord-252443-lclxrwcm	180	51	vaccination	vaccination	NN
cord-252443-lclxrwcm	180	52	against	against	IN
cord-252443-lclxrwcm	180	53	seasonal	seasonal	JJ
cord-252443-lclxrwcm	180	54	and	and	CC
cord-252443-lclxrwcm	180	55	pandemic	pandemic	NN
cord-252443-lclxrwcm	180	56	influenza	influenza	NN
cord-252443-lclxrwcm	180	57	virus	virus	NN
cord-252443-lclxrwcm	180	58	infection	infection	NN
cord-252443-lclxrwcm	180	59	during	during	IN
cord-252443-lclxrwcm	180	60	2009	2009	CD
cord-252443-lclxrwcm	180	61	in	in	IN
cord-252443-lclxrwcm	180	62	Hong	Hong	NNP
cord-252443-lclxrwcm	180	63	Kong	Kong	NNP
cord-252443-lclxrwcm	180	64	Annual	annual	JJ
cord-252443-lclxrwcm	180	65	vaccination	vaccination	NN
cord-252443-lclxrwcm	180	66	against	against	IN
cord-252443-lclxrwcm	180	67	influenza	influenza	NNP
cord-252443-lclxrwcm	180	68	virus	virus	NN
cord-252443-lclxrwcm	180	69	hampers	hamper	VBZ
cord-252443-lclxrwcm	180	70	development	development	NN
cord-252443-lclxrwcm	180	71	of	of	IN
cord-252443-lclxrwcm	180	72	virus	virus	NN
cord-252443-lclxrwcm	180	73	-	-	HYPH
cord-252443-lclxrwcm	180	74	specific	specific	JJ
cord-252443-lclxrwcm	180	75	CD8	CD8	NNP
cord-252443-lclxrwcm	180	76	T	T	NNP
cord-252443-lclxrwcm	180	77	cell	cell	NN
cord-252443-lclxrwcm	180	78	immunity	immunity	NN
cord-252443-lclxrwcm	180	79	in	in	IN
cord-252443-lclxrwcm	180	80	children	child	NNS
cord-252443-lclxrwcm	181	1	How	how	WRB
cord-252443-lclxrwcm	181	2	did	do	VBD
cord-252443-lclxrwcm	181	3	the	the	DT
cord-252443-lclxrwcm	181	4	2008	2008	CD
cord-252443-lclxrwcm	181	5	-	-	SYM
cord-252443-lclxrwcm	181	6	2009	2009	CD
cord-252443-lclxrwcm	181	7	seasonal	seasonal	JJ
cord-252443-lclxrwcm	181	8	influenza	influenza	NN
cord-252443-lclxrwcm	181	9	vaccine	vaccine	NN
cord-252443-lclxrwcm	181	10	affect	affect	VBP
cord-252443-lclxrwcm	181	11	the	the	DT
cord-252443-lclxrwcm	181	12	pandemic	pandemic	NN
cord-252443-lclxrwcm	181	13	?	?	.
cord-252443-lclxrwcm	182	1	Cross	cross	JJ
cord-252443-lclxrwcm	182	2	-	-	JJ
cord-252443-lclxrwcm	182	3	protective	protective	JJ
cord-252443-lclxrwcm	182	4	immunity	immunity	NN
cord-252443-lclxrwcm	182	5	to	to	TO
cord-252443-lclxrwcm	182	6	influenza	influenza	NN
cord-252443-lclxrwcm	182	7	A	a	DT
cord-252443-lclxrwcm	182	8	viruses	virus	NNS
cord-252443-lclxrwcm	183	1	Preexisting	preexist	VBG
cord-252443-lclxrwcm	183	2	influenzaspecific	influenzaspecific	NNP
cord-252443-lclxrwcm	183	3	CD4(+	cd4(+	CD
cord-252443-lclxrwcm	183	4	)	)	-RRB-
cord-252443-lclxrwcm	184	1	T	t	NN
cord-252443-lclxrwcm	184	2	cells	cell	NNS
cord-252443-lclxrwcm	184	3	correlate	correlate	VBP
cord-252443-lclxrwcm	184	4	with	with	IN
cord-252443-lclxrwcm	184	5	disease	disease	NN
cord-252443-lclxrwcm	184	6	protection	protection	NN
cord-252443-lclxrwcm	184	7	against	against	IN
cord-252443-lclxrwcm	184	8	influenza	influenza	NN
cord-252443-lclxrwcm	184	9	challenge	challenge	NN
cord-252443-lclxrwcm	184	10	in	in	IN
cord-252443-lclxrwcm	184	11	humans	human	NNS
cord-252443-lclxrwcm	185	1	Targeting	target	VBG
cord-252443-lclxrwcm	185	2	B	b	NN
cord-252443-lclxrwcm	185	3	cell	cell	NN
cord-252443-lclxrwcm	185	4	responses	response	NNS
cord-252443-lclxrwcm	185	5	in	in	IN
cord-252443-lclxrwcm	185	6	universal	universal	JJ
cord-252443-lclxrwcm	185	7	influenza	influenza	NN
cord-252443-lclxrwcm	185	8	vaccine	vaccine	NN
cord-252443-lclxrwcm	185	9	design	design	NN
cord-252443-lclxrwcm	185	10	Pandemic	Pandemic	NNP
cord-252443-lclxrwcm	185	11	influenza	influenza	NN
cord-252443-lclxrwcm	185	12	vaccines	vaccine	NNS
cord-252443-lclxrwcm	185	13	Influenza	Influenza	NNP
cord-252443-lclxrwcm	185	14	vaccine	vaccine	NN
cord-252443-lclxrwcm	185	15	effectiveness	effectiveness	NN
cord-252443-lclxrwcm	185	16	in	in	IN
cord-252443-lclxrwcm	185	17	preventing	prevent	VBG
cord-252443-lclxrwcm	185	18	hospitalizations	hospitalization	NNS
cord-252443-lclxrwcm	185	19	and	and	CC
cord-252443-lclxrwcm	185	20	deaths	death	NNS
cord-252443-lclxrwcm	185	21	in	in	IN
cord-252443-lclxrwcm	185	22	persons	person	NNS
cord-252443-lclxrwcm	185	23	65	65	CD
cord-252443-lclxrwcm	185	24	years	year	NNS
cord-252443-lclxrwcm	185	25	or	or	CC
cord-252443-lclxrwcm	185	26	older	old	JJR
cord-252443-lclxrwcm	185	27	in	in	IN
cord-252443-lclxrwcm	185	28	Minnesota	Minnesota	NNP
cord-252443-lclxrwcm	185	29	Age	Age	NNP
cord-252443-lclxrwcm	185	30	-	-	HYPH
cord-252443-lclxrwcm	185	31	related	relate	VBN
cord-252443-lclxrwcm	185	32	changes	change	NNS
cord-252443-lclxrwcm	185	33	in	in	IN
cord-252443-lclxrwcm	185	34	immunity	immunity	NN
cord-252443-lclxrwcm	185	35	:	:	:
cord-252443-lclxrwcm	185	36	implications	implication	NNS
cord-252443-lclxrwcm	185	37	for	for	IN
cord-252443-lclxrwcm	185	38	vaccination	vaccination	NN
cord-252443-lclxrwcm	185	39	in	in	IN
cord-252443-lclxrwcm	185	40	the	the	DT
cord-252443-lclxrwcm	185	41	elderly	elderly	JJ
cord-252443-lclxrwcm	185	42	Vaccines	vaccine	NNS
cord-252443-lclxrwcm	185	43	for	for	IN
cord-252443-lclxrwcm	185	44	preventing	prevent	VBG
cord-252443-lclxrwcm	185	45	influenza	influenza	NN
cord-252443-lclxrwcm	185	46	in	in	IN
cord-252443-lclxrwcm	185	47	healthy	healthy	JJ
cord-252443-lclxrwcm	185	48	adults	adult	NNS
cord-252443-lclxrwcm	186	1	Vaccines	vaccine	NNS
cord-252443-lclxrwcm	186	2	for	for	IN
cord-252443-lclxrwcm	186	3	preventing	prevent	VBG
cord-252443-lclxrwcm	186	4	influenza	influenza	NN
cord-252443-lclxrwcm	186	5	in	in	IN
cord-252443-lclxrwcm	186	6	healthy	healthy	JJ
cord-252443-lclxrwcm	186	7	adults	adult	NNS
cord-252443-lclxrwcm	187	1	Vaccines	vaccine	NNS
cord-252443-lclxrwcm	187	2	for	for	IN
cord-252443-lclxrwcm	187	3	preventing	prevent	VBG
cord-252443-lclxrwcm	187	4	influenza	influenza	NN
cord-252443-lclxrwcm	187	5	in	in	IN
cord-252443-lclxrwcm	187	6	healthy	healthy	JJ
cord-252443-lclxrwcm	187	7	children	child	NNS
cord-252443-lclxrwcm	187	8	Influenza	Influenza	NNP
cord-252443-lclxrwcm	187	9	vaccination	vaccination	NN
cord-252443-lclxrwcm	187	10	and	and	CC
cord-252443-lclxrwcm	187	11	risk	risk	NN
cord-252443-lclxrwcm	187	12	of	of	IN
cord-252443-lclxrwcm	187	13	community	community	NN
cord-252443-lclxrwcm	187	14	-	-	HYPH
cord-252443-lclxrwcm	187	15	acquired	acquire	VBN
cord-252443-lclxrwcm	187	16	pneumonia	pneumonia	NN
cord-252443-lclxrwcm	187	17	in	in	IN
cord-252443-lclxrwcm	187	18	immunocompetent	immunocompetent	JJ
cord-252443-lclxrwcm	187	19	elderly	elderly	JJ
cord-252443-lclxrwcm	187	20	people	people	NNS
cord-252443-lclxrwcm	187	21	:	:	:
cord-252443-lclxrwcm	188	1	a	a	DT
cord-252443-lclxrwcm	188	2	populationbased	populationbased	JJ
cord-252443-lclxrwcm	188	3	,	,	,
cord-252443-lclxrwcm	188	4	nested	nested	JJ
cord-252443-lclxrwcm	188	5	case	case	NN
cord-252443-lclxrwcm	188	6	-	-	HYPH
cord-252443-lclxrwcm	188	7	control	control	NN
cord-252443-lclxrwcm	188	8	study	study	NN
cord-252443-lclxrwcm	188	9	Vaccines	vaccine	NNS
cord-252443-lclxrwcm	188	10	for	for	IN
cord-252443-lclxrwcm	188	11	preventing	prevent	VBG
cord-252443-lclxrwcm	188	12	influenza	influenza	NN
cord-252443-lclxrwcm	188	13	in	in	IN
cord-252443-lclxrwcm	188	14	the	the	DT
cord-252443-lclxrwcm	188	15	elderly	elderly	JJ
cord-252443-lclxrwcm	188	16	Current	current	JJ
cord-252443-lclxrwcm	188	17	status	status	NN
cord-252443-lclxrwcm	188	18	of	of	IN
cord-252443-lclxrwcm	188	19	live	live	JJ
cord-252443-lclxrwcm	188	20	attenuated	attenuated	JJ
cord-252443-lclxrwcm	188	21	influenza	influenza	NN
cord-252443-lclxrwcm	188	22	vaccine	vaccine	NN
cord-252443-lclxrwcm	188	23	in	in	IN
cord-252443-lclxrwcm	188	24	the	the	DT
cord-252443-lclxrwcm	188	25	United	United	NNP
cord-252443-lclxrwcm	188	26	States	States	NNP
cord-252443-lclxrwcm	188	27	for	for	IN
cord-252443-lclxrwcm	188	28	seasonal	seasonal	JJ
cord-252443-lclxrwcm	188	29	and	and	CC
cord-252443-lclxrwcm	188	30	pandemic	pandemic	NN
cord-252443-lclxrwcm	188	31	influenza	influenza	NN
cord-252443-lclxrwcm	188	32	Influenza	Influenza	NNP
cord-252443-lclxrwcm	188	33	and	and	CC
cord-252443-lclxrwcm	188	34	the	the	DT
cord-252443-lclxrwcm	188	35	challenge	challenge	NN
cord-252443-lclxrwcm	188	36	for	for	IN
cord-252443-lclxrwcm	188	37	immunology	immunology	NN
cord-252443-lclxrwcm	188	38	Structural	structural	JJ
cord-252443-lclxrwcm	188	39	basis	basis	NN
cord-252443-lclxrwcm	188	40	of	of	IN
cord-252443-lclxrwcm	188	41	immune	immune	JJ
cord-252443-lclxrwcm	188	42	recognition	recognition	NN
cord-252443-lclxrwcm	188	43	of	of	IN
cord-252443-lclxrwcm	188	44	influenza	influenza	NN
cord-252443-lclxrwcm	188	45	virus	virus	NN
cord-252443-lclxrwcm	188	46	hemagglutinin	hemagglutinin	NN
cord-252443-lclxrwcm	188	47	Cytotoxic	Cytotoxic	NNP
cord-252443-lclxrwcm	188	48	T	t	NN
cord-252443-lclxrwcm	188	49	-	-	HYPH
cord-252443-lclxrwcm	188	50	cell	cell	NN
cord-252443-lclxrwcm	188	51	immunity	immunity	NN
cord-252443-lclxrwcm	188	52	to	to	IN
cord-252443-lclxrwcm	188	53	influenza	influenza	NN
cord-252443-lclxrwcm	188	54	Immunity	immunity	NN
cord-252443-lclxrwcm	188	55	to	to	IN
cord-252443-lclxrwcm	188	56	pre-1950	pre-1950	NNS
cord-252443-lclxrwcm	188	57	H1N1	H1N1	NNP
cord-252443-lclxrwcm	188	58	influenza	influenza	NN
cord-252443-lclxrwcm	188	59	viruses	virus	NNS
cord-252443-lclxrwcm	188	60	confers	confer	VBZ
cord-252443-lclxrwcm	188	61	cross	cross	NN
cord-252443-lclxrwcm	188	62	-	-	NN
cord-252443-lclxrwcm	188	63	protection	protection	NN
cord-252443-lclxrwcm	188	64	against	against	IN
cord-252443-lclxrwcm	188	65	the	the	DT
cord-252443-lclxrwcm	188	66	pandemic	pandemic	NN
cord-252443-lclxrwcm	188	67	swine	swine	NN
cord-252443-lclxrwcm	188	68	-	-	HYPH
cord-252443-lclxrwcm	188	69	origin	origin	NN
cord-252443-lclxrwcm	188	70	2009	2009	CD
cord-252443-lclxrwcm	188	71	A	A	NNP
cord-252443-lclxrwcm	188	72	(	(	-LRB-
cord-252443-lclxrwcm	188	73	H1N1	H1N1	NNP
cord-252443-lclxrwcm	188	74	)	)	-RRB-
cord-252443-lclxrwcm	188	75	influenza	influenza	NN
cord-252443-lclxrwcm	188	76	virus	virus	NN
cord-252443-lclxrwcm	188	77	A	a	DT
cord-252443-lclxrwcm	188	78	neutralizing	neutralize	VBG
cord-252443-lclxrwcm	188	79	antibody	antibody	NN
cord-252443-lclxrwcm	188	80	selected	select	VBN
cord-252443-lclxrwcm	188	81	from	from	IN
cord-252443-lclxrwcm	188	82	plasma	plasma	NN
cord-252443-lclxrwcm	188	83	cells	cell	NNS
cord-252443-lclxrwcm	188	84	that	that	WDT
cord-252443-lclxrwcm	188	85	binds	bind	VBZ
cord-252443-lclxrwcm	188	86	to	to	IN
cord-252443-lclxrwcm	188	87	group	group	NN
cord-252443-lclxrwcm	188	88	1	1	CD
cord-252443-lclxrwcm	188	89	and	and	CC
cord-252443-lclxrwcm	188	90	group	group	NN
cord-252443-lclxrwcm	188	91	2	2	CD
cord-252443-lclxrwcm	188	92	influenza	influenza	NN
cord-252443-lclxrwcm	188	93	A	a	DT
cord-252443-lclxrwcm	188	94	hemagglutinins	hemagglutinins	NNP
cord-252443-lclxrwcm	188	95	Protection	Protection	NNP
cord-252443-lclxrwcm	188	96	against	against	IN
cord-252443-lclxrwcm	188	97	multiple	multiple	JJ
cord-252443-lclxrwcm	188	98	influenza	influenza	NN
cord-252443-lclxrwcm	188	99	A	a	DT
cord-252443-lclxrwcm	188	100	subtypes	subtypes	NN
cord-252443-lclxrwcm	188	101	by	by	IN
cord-252443-lclxrwcm	188	102	vaccination	vaccination	NN
cord-252443-lclxrwcm	188	103	with	with	IN
cord-252443-lclxrwcm	188	104	highly	highly	RB
cord-252443-lclxrwcm	188	105	conserved	conserve	VBN
cord-252443-lclxrwcm	188	106	nucleoprotein	nucleoprotein	JJ
cord-252443-lclxrwcm	188	107	Electroporation	Electroporation	NNP
cord-252443-lclxrwcm	188	108	of	of	IN
cord-252443-lclxrwcm	188	109	synthetic	synthetic	JJ
cord-252443-lclxrwcm	188	110	DNA	dna	NN
cord-252443-lclxrwcm	188	111	antigens	antigen	NNS
cord-252443-lclxrwcm	188	112	offers	offer	VBZ
cord-252443-lclxrwcm	188	113	protection	protection	NN
cord-252443-lclxrwcm	188	114	in	in	IN
cord-252443-lclxrwcm	188	115	nonhuman	nonhuman	NN
cord-252443-lclxrwcm	188	116	primates	primate	NNS
cord-252443-lclxrwcm	188	117	challenged	challenge	VBN
cord-252443-lclxrwcm	188	118	with	with	IN
cord-252443-lclxrwcm	188	119	highly	highly	RB
cord-252443-lclxrwcm	188	120	pathogenic	pathogenic	JJ
cord-252443-lclxrwcm	188	121	avian	avian	JJ
cord-252443-lclxrwcm	188	122	influenza	influenza	NN
cord-252443-lclxrwcm	188	123	virus	virus	NN
cord-252443-lclxrwcm	188	124	Declining	decline	VBG
cord-252443-lclxrwcm	188	125	T	t	NN
cord-252443-lclxrwcm	188	126	-	-	HYPH
cord-252443-lclxrwcm	188	127	cell	cell	NN
cord-252443-lclxrwcm	188	128	immunity	immunity	NN
cord-252443-lclxrwcm	188	129	to	to	IN
cord-252443-lclxrwcm	188	130	influenza	influenza	NN
cord-252443-lclxrwcm	188	131	CD8	CD8	NNP
cord-252443-lclxrwcm	188	132	+	+	CC
cord-252443-lclxrwcm	188	133	T	T	NNP
cord-252443-lclxrwcm	188	134	cells	cell	NNS
cord-252443-lclxrwcm	188	135	clear	clear	JJ
cord-252443-lclxrwcm	188	136	influenza	influenza	NN
cord-252443-lclxrwcm	188	137	virus	virus	NN
cord-252443-lclxrwcm	188	138	by	by	IN
cord-252443-lclxrwcm	188	139	perforin	perforin	NNP
cord-252443-lclxrwcm	188	140	or	or	CC
cord-252443-lclxrwcm	188	141	Fasdependent	Fasdependent	NNP
cord-252443-lclxrwcm	188	142	processes	process	NNS
cord-252443-lclxrwcm	189	1	Cytotoxic	Cytotoxic	NNP
cord-252443-lclxrwcm	189	2	T	t	NN
cord-252443-lclxrwcm	189	3	cells	cell	NNS
cord-252443-lclxrwcm	189	4	are	be	VBP
cord-252443-lclxrwcm	189	5	the	the	DT
cord-252443-lclxrwcm	189	6	predominant	predominant	JJ
cord-252443-lclxrwcm	189	7	players	player	NNS
cord-252443-lclxrwcm	189	8	providing	provide	VBG
cord-252443-lclxrwcm	189	9	cross	cross	JJ
cord-252443-lclxrwcm	189	10	-	-	JJ
cord-252443-lclxrwcm	189	11	protective	protective	JJ
cord-252443-lclxrwcm	189	12	immunity	immunity	NN
cord-252443-lclxrwcm	189	13	induced	induce	VBN
cord-252443-lclxrwcm	189	14	by	by	IN
cord-252443-lclxrwcm	189	15	{	{	-LRB-
cord-252443-lclxrwcm	189	16	gamma}-irradiated	gamma}-irradiate	VBN
cord-252443-lclxrwcm	189	17	influenza	influenza	NN
cord-252443-lclxrwcm	189	18	A	a	DT
cord-252443-lclxrwcm	189	19	viruses	virus	NNS
cord-252443-lclxrwcm	189	20	CD4	CD4	NNP
cord-252443-lclxrwcm	189	21	T	T	NNP
cord-252443-lclxrwcm	189	22	cell	cell	NN
cord-252443-lclxrwcm	189	23	-	-	HYPH
cord-252443-lclxrwcm	189	24	mediated	mediate	VBN
cord-252443-lclxrwcm	189	25	protection	protection	NN
cord-252443-lclxrwcm	189	26	from	from	IN
cord-252443-lclxrwcm	189	27	lethal	lethal	JJ
cord-252443-lclxrwcm	189	28	influenza	influenza	NN
cord-252443-lclxrwcm	189	29	:	:	:
cord-252443-lclxrwcm	189	30	perforin	perforin	NNP
cord-252443-lclxrwcm	189	31	and	and	CC
cord-252443-lclxrwcm	189	32	antibody	antibody	NN
cord-252443-lclxrwcm	189	33	-	-	HYPH
cord-252443-lclxrwcm	189	34	mediated	mediate	VBN
cord-252443-lclxrwcm	189	35	mechanisms	mechanism	NNS
cord-252443-lclxrwcm	189	36	give	give	VBP
cord-252443-lclxrwcm	189	37	a	a	DT
cord-252443-lclxrwcm	189	38	one	one	CD
cord-252443-lclxrwcm	189	39	-	-	HYPH
cord-252443-lclxrwcm	189	40	two	two	CD
cord-252443-lclxrwcm	189	41	punch	punch	NN
cord-252443-lclxrwcm	189	42	T	t	NN
cord-252443-lclxrwcm	189	43	cells	cell	NNS
cord-252443-lclxrwcm	189	44	primed	prime	VBN
cord-252443-lclxrwcm	189	45	by	by	IN
cord-252443-lclxrwcm	189	46	influenza	influenza	NN
cord-252443-lclxrwcm	189	47	virion	virion	NN
cord-252443-lclxrwcm	189	48	internal	internal	JJ
cord-252443-lclxrwcm	189	49	components	component	NNS
cord-252443-lclxrwcm	189	50	can	can	MD
cord-252443-lclxrwcm	189	51	cooperate	cooperate	VB
cord-252443-lclxrwcm	189	52	in	in	IN
cord-252443-lclxrwcm	189	53	the	the	DT
cord-252443-lclxrwcm	189	54	antibody	antibody	NN
cord-252443-lclxrwcm	189	55	response	response	NN
cord-252443-lclxrwcm	189	56	to	to	TO
cord-252443-lclxrwcm	189	57	haemagglutinin	haemagglutinin	VB
cord-252443-lclxrwcm	189	58	Functional	functional	JJ
cord-252443-lclxrwcm	189	59	analysis	analysis	NN
cord-252443-lclxrwcm	189	60	of	of	IN
cord-252443-lclxrwcm	189	61	influenza	influenza	NN
cord-252443-lclxrwcm	189	62	-	-	HYPH
cord-252443-lclxrwcm	189	63	specific	specific	JJ
cord-252443-lclxrwcm	189	64	helper	helper	NN
cord-252443-lclxrwcm	189	65	T	t	NN
cord-252443-lclxrwcm	189	66	cell	cell	NN
cord-252443-lclxrwcm	189	67	clones	clone	NNS
cord-252443-lclxrwcm	189	68	in	in	IN
cord-252443-lclxrwcm	189	69	vivo	vivo	NN
cord-252443-lclxrwcm	189	70	.	.	.
cord-252443-lclxrwcm	190	1	T	t	NN
cord-252443-lclxrwcm	190	2	cells	cell	NNS
cord-252443-lclxrwcm	190	3	specific	specific	JJ
cord-252443-lclxrwcm	190	4	for	for	IN
cord-252443-lclxrwcm	190	5	internal	internal	JJ
cord-252443-lclxrwcm	190	6	viral	viral	JJ
cord-252443-lclxrwcm	190	7	proteins	protein	NNS
cord-252443-lclxrwcm	190	8	provide	provide	VBP
cord-252443-lclxrwcm	190	9	cognate	cognate	JJ
cord-252443-lclxrwcm	190	10	help	help	NN
cord-252443-lclxrwcm	190	11	for	for	IN
cord-252443-lclxrwcm	190	12	B	b	NN
cord-252443-lclxrwcm	190	13	cell	cell	NN
cord-252443-lclxrwcm	190	14	responses	response	NNS
cord-252443-lclxrwcm	190	15	to	to	IN
cord-252443-lclxrwcm	190	16	hemagglutinin	hemagglutinin	VB
cord-252443-lclxrwcm	190	17	Influenza	Influenza	NNP
cord-252443-lclxrwcm	190	18	A	a	DT
cord-252443-lclxrwcm	190	19	virus	virus	NN
cord-252443-lclxrwcm	190	20	matrix	matrix	NN
cord-252443-lclxrwcm	190	21	protein	protein	NN
cord-252443-lclxrwcm	190	22	1-specific	1-specific	CD
cord-252443-lclxrwcm	190	23	human	human	JJ
cord-252443-lclxrwcm	190	24	CD8	CD8	NNP
cord-252443-lclxrwcm	190	25	+	+	CC
cord-252443-lclxrwcm	190	26	T	T	NNP
cord-252443-lclxrwcm	190	27	-	-	HYPH
cord-252443-lclxrwcm	190	28	cell	cell	NN
cord-252443-lclxrwcm	190	29	response	response	NN
cord-252443-lclxrwcm	190	30	induced	induce	VBN
cord-252443-lclxrwcm	190	31	in	in	IN
cord-252443-lclxrwcm	190	32	trivalent	trivalent	JJ
cord-252443-lclxrwcm	190	33	inactivated	inactivate	VBN
cord-252443-lclxrwcm	190	34	vaccine	vaccine	NN
cord-252443-lclxrwcm	190	35	recipients	recipient	NNS
cord-252443-lclxrwcm	190	36	Morphological	morphological	JJ
cord-252443-lclxrwcm	190	37	and	and	CC
cord-252443-lclxrwcm	190	38	biochemical	biochemical	JJ
cord-252443-lclxrwcm	190	39	characterization	characterization	NN
cord-252443-lclxrwcm	190	40	of	of	IN
cord-252443-lclxrwcm	190	41	influenza	influenza	NN
cord-252443-lclxrwcm	190	42	vaccines	vaccine	NNS
cord-252443-lclxrwcm	190	43	commercially	commercially	RB
cord-252443-lclxrwcm	190	44	available	available	JJ
cord-252443-lclxrwcm	190	45	in	in	IN
cord-252443-lclxrwcm	190	46	the	the	DT
cord-252443-lclxrwcm	190	47	United	United	NNP
cord-252443-lclxrwcm	190	48	Kingdom	Kingdom	NNP
cord-252443-lclxrwcm	190	49	Cellular	Cellular	NNP
cord-252443-lclxrwcm	190	50	immune	immune	JJ
cord-252443-lclxrwcm	190	51	responses	response	NNS
cord-252443-lclxrwcm	190	52	in	in	IN
cord-252443-lclxrwcm	190	53	children	child	NNS
cord-252443-lclxrwcm	190	54	and	and	CC
cord-252443-lclxrwcm	190	55	adults	adult	NNS
cord-252443-lclxrwcm	190	56	receiving	receive	VBG
cord-252443-lclxrwcm	190	57	inactivated	inactivate	VBN
cord-252443-lclxrwcm	190	58	or	or	CC
cord-252443-lclxrwcm	190	59	live	live	JJ
cord-252443-lclxrwcm	191	1	attenuated	attenuated	JJ
cord-252443-lclxrwcm	191	2	influenza	influenza	NN
cord-252443-lclxrwcm	191	3	vaccines	vaccine	NNS
cord-252443-lclxrwcm	191	4	Influenza	Influenza	NNP
cord-252443-lclxrwcm	191	5	vaccine	vaccine	NN
cord-252443-lclxrwcm	191	6	:	:	:
cord-252443-lclxrwcm	191	7	the	the	DT
cord-252443-lclxrwcm	191	8	challenge	challenge	NN
cord-252443-lclxrwcm	191	9	of	of	IN
cord-252443-lclxrwcm	191	10	antigenic	antigenic	JJ
cord-252443-lclxrwcm	191	11	drift	drift	NN
cord-252443-lclxrwcm	191	12	Influenza	Influenza	NNP
cord-252443-lclxrwcm	191	13	control	control	NN
cord-252443-lclxrwcm	191	14	in	in	IN
cord-252443-lclxrwcm	191	15	the	the	DT
cord-252443-lclxrwcm	191	16	21st	21st	JJ
cord-252443-lclxrwcm	191	17	century	century	NN
cord-252443-lclxrwcm	191	18	:	:	:
cord-252443-lclxrwcm	191	19	optimizing	optimize	VBG
cord-252443-lclxrwcm	191	20	protection	protection	NN
cord-252443-lclxrwcm	191	21	of	of	IN
cord-252443-lclxrwcm	191	22	older	old	JJR
cord-252443-lclxrwcm	191	23	adults	adult	NNS
cord-252443-lclxrwcm	191	24	Towards	towards	IN
cord-252443-lclxrwcm	191	25	universal	universal	JJ
cord-252443-lclxrwcm	191	26	influenza	influenza	NN
cord-252443-lclxrwcm	191	27	vaccines	vaccine	NNS
cord-252443-lclxrwcm	191	28	?	?	.
cord-252443-lclxrwcm	192	1	Philos	Philos	NNP
cord-252443-lclxrwcm	192	2	Mode	Mode	NNP
cord-252443-lclxrwcm	192	3	of	of	IN
cord-252443-lclxrwcm	192	4	action	action	NN
cord-252443-lclxrwcm	192	5	of	of	IN
cord-252443-lclxrwcm	192	6	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	192	7	:	:	:
cord-252443-lclxrwcm	192	8	implications	implication	NNS
cord-252443-lclxrwcm	192	9	for	for	IN
cord-252443-lclxrwcm	192	10	vaccine	vaccine	NN
cord-252443-lclxrwcm	192	11	safety	safety	NN
cord-252443-lclxrwcm	192	12	and	and	CC
cord-252443-lclxrwcm	192	13	design	design	NN
cord-252443-lclxrwcm	192	14	Towards	towards	IN
cord-252443-lclxrwcm	192	15	an	an	DT
cord-252443-lclxrwcm	192	16	understanding	understanding	NN
cord-252443-lclxrwcm	192	17	of	of	IN
cord-252443-lclxrwcm	192	18	the	the	DT
cord-252443-lclxrwcm	192	19	adjuvant	adjuvant	JJ
cord-252443-lclxrwcm	192	20	action	action	NN
cord-252443-lclxrwcm	192	21	of	of	IN
cord-252443-lclxrwcm	192	22	aluminium	aluminium	NN
cord-252443-lclxrwcm	192	23	Topical	topical	JJ
cord-252443-lclxrwcm	192	24	immunization	immunization	NN
cord-252443-lclxrwcm	192	25	strategies	strategy	NNS
cord-252443-lclxrwcm	192	26	Vaccines	Vaccines	NNPS
cord-252443-lclxrwcm	192	27	with	with	IN
cord-252443-lclxrwcm	192	28	MF59	MF59	NNP
cord-252443-lclxrwcm	192	29	adjuvant	adjuvant	NN
cord-252443-lclxrwcm	192	30	expand	expand	VBP
cord-252443-lclxrwcm	192	31	the	the	DT
cord-252443-lclxrwcm	192	32	antibody	antibody	NN
cord-252443-lclxrwcm	192	33	repertoire	repertoire	NN
cord-252443-lclxrwcm	192	34	to	to	TO
cord-252443-lclxrwcm	192	35	target	target	VB
cord-252443-lclxrwcm	192	36	protective	protective	JJ
cord-252443-lclxrwcm	192	37	sites	site	NNS
cord-252443-lclxrwcm	192	38	of	of	IN
cord-252443-lclxrwcm	192	39	pandemic	pandemic	NN
cord-252443-lclxrwcm	192	40	avian	avian	JJ
cord-252443-lclxrwcm	192	41	H5N1	H5N1	NNP
cord-252443-lclxrwcm	192	42	influenza	influenza	NN
cord-252443-lclxrwcm	192	43	virus	virus	NN
cord-252443-lclxrwcm	192	44	MF59	MF59	NNP
cord-252443-lclxrwcm	192	45	adjuvant	adjuvant	NN
cord-252443-lclxrwcm	192	46	enhances	enhance	VBZ
cord-252443-lclxrwcm	192	47	diversity	diversity	NN
cord-252443-lclxrwcm	192	48	and	and	CC
cord-252443-lclxrwcm	192	49	affinity	affinity	NN
cord-252443-lclxrwcm	192	50	of	of	IN
cord-252443-lclxrwcm	192	51	antibody	antibody	NN
cord-252443-lclxrwcm	192	52	-	-	HYPH
cord-252443-lclxrwcm	192	53	mediated	mediate	VBN
cord-252443-lclxrwcm	192	54	immune	immune	JJ
cord-252443-lclxrwcm	192	55	response	response	NN
cord-252443-lclxrwcm	192	56	to	to	IN
cord-252443-lclxrwcm	192	57	pandemic	pandemic	NN
cord-252443-lclxrwcm	192	58	influenza	influenza	NN
cord-252443-lclxrwcm	192	59	vaccines	vaccine	NNS
cord-252443-lclxrwcm	192	60	Immunogenicity	Immunogenicity	NNP
cord-252443-lclxrwcm	192	61	of	of	IN
cord-252443-lclxrwcm	192	62	three	three	CD
cord-252443-lclxrwcm	192	63	different	different	JJ
cord-252443-lclxrwcm	192	64	influenza	influenza	NN
cord-252443-lclxrwcm	192	65	vaccines	vaccine	NNS
cord-252443-lclxrwcm	192	66	against	against	IN
cord-252443-lclxrwcm	192	67	homologous	homologous	JJ
cord-252443-lclxrwcm	192	68	and	and	CC
cord-252443-lclxrwcm	192	69	heterologous	heterologous	JJ
cord-252443-lclxrwcm	192	70	strains	strain	NNS
cord-252443-lclxrwcm	192	71	in	in	IN
cord-252443-lclxrwcm	192	72	nursing	nurse	VBG
cord-252443-lclxrwcm	192	73	home	home	NN
cord-252443-lclxrwcm	192	74	elderly	elderly	JJ
cord-252443-lclxrwcm	192	75	residents	resident	NNS
cord-252443-lclxrwcm	192	76	Safety	Safety	NNP
cord-252443-lclxrwcm	192	77	of	of	IN
cord-252443-lclxrwcm	192	78	MF59	MF59	NNP
cord-252443-lclxrwcm	192	79	adjuvant	adjuvant	NN
cord-252443-lclxrwcm	192	80	Trends	trend	NNS
cord-252443-lclxrwcm	192	81	in	in	IN
cord-252443-lclxrwcm	192	82	vaccine	vaccine	NN
cord-252443-lclxrwcm	192	83	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	192	84	Safety	safety	NN
cord-252443-lclxrwcm	192	85	and	and	CC
cord-252443-lclxrwcm	192	86	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	192	87	of	of	IN
cord-252443-lclxrwcm	192	88	a	a	DT
cord-252443-lclxrwcm	192	89	recombinant	recombinant	JJ
cord-252443-lclxrwcm	192	90	M2e	m2e	NN
cord-252443-lclxrwcm	192	91	-	-	HYPH
cord-252443-lclxrwcm	192	92	flagellin	flagellin	JJ
cord-252443-lclxrwcm	192	93	influenza	influenza	NN
cord-252443-lclxrwcm	192	94	vaccine	vaccine	NN
cord-252443-lclxrwcm	192	95	(	(	-LRB-
cord-252443-lclxrwcm	192	96	STF2.4xM2e	stf2.4xm2e	NN
cord-252443-lclxrwcm	192	97	)	)	-RRB-
cord-252443-lclxrwcm	192	98	in	in	IN
cord-252443-lclxrwcm	192	99	healthy	healthy	JJ
cord-252443-lclxrwcm	192	100	adults	adult	NNS
cord-252443-lclxrwcm	192	101	Clinical	clinical	JJ
cord-252443-lclxrwcm	192	102	development	development	NN
cord-252443-lclxrwcm	192	103	of	of	IN
cord-252443-lclxrwcm	192	104	plant	plant	NN
cord-252443-lclxrwcm	192	105	-	-	HYPH
cord-252443-lclxrwcm	192	106	produced	produce	VBN
cord-252443-lclxrwcm	192	107	recombinant	recombinant	JJ
cord-252443-lclxrwcm	192	108	pharmaceuticals	pharmaceutical	NNS
cord-252443-lclxrwcm	192	109	:	:	:
cord-252443-lclxrwcm	192	110	vaccines	vaccine	NNS
cord-252443-lclxrwcm	192	111	,	,	,
cord-252443-lclxrwcm	192	112	antibodies	antibody	NNS
cord-252443-lclxrwcm	192	113	and	and	CC
cord-252443-lclxrwcm	192	114	beyond	beyond	IN
cord-252443-lclxrwcm	192	115	Alternative	alternative	JJ
cord-252443-lclxrwcm	192	116	influenza	influenza	NN
cord-252443-lclxrwcm	192	117	vaccines	vaccine	NNS
cord-252443-lclxrwcm	192	118	made	make	VBN
cord-252443-lclxrwcm	192	119	by	by	IN
cord-252443-lclxrwcm	192	120	insect	insect	NN
cord-252443-lclxrwcm	192	121	cells	cell	NNS
cord-252443-lclxrwcm	193	1	The	the	DT
cord-252443-lclxrwcm	193	2	requirement	requirement	NN
cord-252443-lclxrwcm	193	3	for	for	IN
cord-252443-lclxrwcm	193	4	potent	potent	JJ
cord-252443-lclxrwcm	193	5	adjuvants	adjuvant	NNS
cord-252443-lclxrwcm	193	6	to	to	TO
cord-252443-lclxrwcm	193	7	enhance	enhance	VB
cord-252443-lclxrwcm	193	8	the	the	DT
cord-252443-lclxrwcm	193	9	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	193	10	and	and	CC
cord-252443-lclxrwcm	193	11	protective	protective	JJ
cord-252443-lclxrwcm	193	12	efficacy	efficacy	NN
cord-252443-lclxrwcm	193	13	of	of	IN
cord-252443-lclxrwcm	193	14	protein	protein	NN
cord-252443-lclxrwcm	193	15	vaccines	vaccine	NNS
cord-252443-lclxrwcm	193	16	can	can	MD
cord-252443-lclxrwcm	193	17	be	be	VB
cord-252443-lclxrwcm	193	18	overcome	overcome	VBN
cord-252443-lclxrwcm	193	19	by	by	IN
cord-252443-lclxrwcm	193	20	prior	prior	JJ
cord-252443-lclxrwcm	193	21	immunization	immunization	NN
cord-252443-lclxrwcm	193	22	with	with	IN
cord-252443-lclxrwcm	193	23	a	a	DT
cord-252443-lclxrwcm	193	24	recombinant	recombinant	JJ
cord-252443-lclxrwcm	193	25	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	193	26	T	t	NN
cord-252443-lclxrwcm	193	27	cell	cell	NN
cord-252443-lclxrwcm	193	28	priming	priming	NN
cord-252443-lclxrwcm	193	29	versus	versus	IN
cord-252443-lclxrwcm	193	30	T	t	NN
cord-252443-lclxrwcm	193	31	cell	cell	NN
cord-252443-lclxrwcm	193	32	tolerance	tolerance	NN
cord-252443-lclxrwcm	193	33	induced	induce	VBN
cord-252443-lclxrwcm	193	34	by	by	IN
cord-252443-lclxrwcm	193	35	synthetic	synthetic	JJ
cord-252443-lclxrwcm	193	36	peptides	peptide	NNS
cord-252443-lclxrwcm	193	37	Phase	Phase	NNP
cord-252443-lclxrwcm	193	38	1	1	CD
cord-252443-lclxrwcm	193	39	clinical	clinical	JJ
cord-252443-lclxrwcm	193	40	trials	trial	NNS
cord-252443-lclxrwcm	193	41	of	of	IN
cord-252443-lclxrwcm	193	42	the	the	DT
cord-252443-lclxrwcm	193	43	safety	safety	NN
cord-252443-lclxrwcm	193	44	and	and	CC
cord-252443-lclxrwcm	193	45	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	193	46	of	of	IN
cord-252443-lclxrwcm	193	47	adjuvanted	adjuvanted	JJ
cord-252443-lclxrwcm	193	48	plasmid	plasmid	NN
cord-252443-lclxrwcm	193	49	DNA	dna	NN
cord-252443-lclxrwcm	193	50	vaccines	vaccine	NNS
cord-252443-lclxrwcm	193	51	encoding	encode	VBG
cord-252443-lclxrwcm	193	52	influenza	influenza	NN
cord-252443-lclxrwcm	193	53	A	a	DT
cord-252443-lclxrwcm	193	54	virus	virus	NN
cord-252443-lclxrwcm	193	55	H5	h5	NN
cord-252443-lclxrwcm	193	56	hemagglutinin	hemagglutinin	NN
cord-252443-lclxrwcm	193	57	DNA	dna	NN
cord-252443-lclxrwcm	193	58	vaccination	vaccination	NN
cord-252443-lclxrwcm	193	59	protects	protect	VBZ
cord-252443-lclxrwcm	193	60	against	against	IN
cord-252443-lclxrwcm	193	61	an	an	DT
cord-252443-lclxrwcm	193	62	influenza	influenza	NN
cord-252443-lclxrwcm	193	63	challenge	challenge	NN
cord-252443-lclxrwcm	193	64	in	in	IN
cord-252443-lclxrwcm	193	65	a	a	DT
cord-252443-lclxrwcm	193	66	double	double	JJ
cord-252443-lclxrwcm	193	67	-	-	HYPH
cord-252443-lclxrwcm	193	68	blind	blind	JJ
cord-252443-lclxrwcm	193	69	randomised	randomised	JJ
cord-252443-lclxrwcm	193	70	placebo	placebo	NN
cord-252443-lclxrwcm	193	71	-	-	HYPH
cord-252443-lclxrwcm	193	72	controlled	control	VBN
cord-252443-lclxrwcm	193	73	phase	phase	NN
cord-252443-lclxrwcm	193	74	1b	1b	CD
cord-252443-lclxrwcm	193	75	clinical	clinical	JJ
cord-252443-lclxrwcm	193	76	trial	trial	NN
cord-252443-lclxrwcm	193	77	Enhanced	Enhanced	NNP
cord-252443-lclxrwcm	193	78	T	t	NN
cord-252443-lclxrwcm	193	79	-	-	HYPH
cord-252443-lclxrwcm	193	80	cell	cell	NN
cord-252443-lclxrwcm	193	81	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	193	82	of	of	IN
cord-252443-lclxrwcm	193	83	plasmid	plasmid	NN
cord-252443-lclxrwcm	193	84	DNA	dna	NN
cord-252443-lclxrwcm	193	85	vaccines	vaccine	NNS
cord-252443-lclxrwcm	193	86	boosted	boost	VBN
cord-252443-lclxrwcm	193	87	by	by	IN
cord-252443-lclxrwcm	193	88	recombinant	recombinant	JJ
cord-252443-lclxrwcm	193	89	modified	modify	VBN
cord-252443-lclxrwcm	193	90	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	193	91	virus	virus	NN
cord-252443-lclxrwcm	193	92	Ankara	Ankara	NNP
cord-252443-lclxrwcm	193	93	in	in	IN
cord-252443-lclxrwcm	193	94	humans	human	NNS
cord-252443-lclxrwcm	193	95	Virus	Virus	NNP
cord-252443-lclxrwcm	193	96	-	-	HYPH
cord-252443-lclxrwcm	193	97	like	like	JJ
cord-252443-lclxrwcm	193	98	particles	particle	NNS
cord-252443-lclxrwcm	193	99	:	:	:
cord-252443-lclxrwcm	193	100	passport	passport	NN
cord-252443-lclxrwcm	193	101	to	to	IN
cord-252443-lclxrwcm	193	102	immune	immune	JJ
cord-252443-lclxrwcm	193	103	recognition	recognition	NN
cord-252443-lclxrwcm	194	1	An	an	DT
cord-252443-lclxrwcm	194	2	overview	overview	NN
cord-252443-lclxrwcm	194	3	on	on	IN
cord-252443-lclxrwcm	194	4	the	the	DT
cord-252443-lclxrwcm	194	5	field	field	NN
cord-252443-lclxrwcm	194	6	of	of	IN
cord-252443-lclxrwcm	194	7	micro	micro	JJ
cord-252443-lclxrwcm	194	8	-	-	HYPH
cord-252443-lclxrwcm	194	9	and	and	CC
cord-252443-lclxrwcm	194	10	nanotechnologies	nanotechnology	NNS
cord-252443-lclxrwcm	194	11	for	for	IN
cord-252443-lclxrwcm	194	12	synthetic	synthetic	JJ
cord-252443-lclxrwcm	194	13	Peptide	Peptide	NNP
cord-252443-lclxrwcm	194	14	-	-	HYPH
cord-252443-lclxrwcm	194	15	based	base	VBN
cord-252443-lclxrwcm	194	16	vaccines	vaccine	NNS
cord-252443-lclxrwcm	194	17	Influenza	Influenza	NNP
cord-252443-lclxrwcm	194	18	virosomes	virosome	VBZ
cord-252443-lclxrwcm	194	19	as	as	IN
cord-252443-lclxrwcm	194	20	a	a	DT
cord-252443-lclxrwcm	194	21	vaccine	vaccine	NN
cord-252443-lclxrwcm	194	22	adjuvant	adjuvant	NN
cord-252443-lclxrwcm	194	23	and	and	CC
cord-252443-lclxrwcm	194	24	carrier	carrier	NN
cord-252443-lclxrwcm	194	25	system	system	NN
cord-252443-lclxrwcm	194	26	Effective	effective	JJ
cord-252443-lclxrwcm	194	27	induction	induction	NN
cord-252443-lclxrwcm	194	28	of	of	IN
cord-252443-lclxrwcm	194	29	high	high	JJ
cord-252443-lclxrwcm	194	30	-	-	HYPH
cord-252443-lclxrwcm	194	31	titer	titer	NN
cord-252443-lclxrwcm	194	32	antibodies	antibody	NNS
cord-252443-lclxrwcm	194	33	by	by	IN
cord-252443-lclxrwcm	194	34	viral	viral	JJ
cord-252443-lclxrwcm	194	35	vector	vector	NN
cord-252443-lclxrwcm	194	36	vaccines	vaccine	NNS
cord-252443-lclxrwcm	194	37	Potent	potent	JJ
cord-252443-lclxrwcm	194	38	CD8	CD8	NNS
cord-252443-lclxrwcm	194	39	+	+	CC
cord-252443-lclxrwcm	194	40	T	t	NN
cord-252443-lclxrwcm	194	41	-	-	HYPH
cord-252443-lclxrwcm	194	42	cell	cell	NN
cord-252443-lclxrwcm	194	43	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	194	44	in	in	IN
cord-252443-lclxrwcm	194	45	humans	human	NNS
cord-252443-lclxrwcm	194	46	of	of	IN
cord-252443-lclxrwcm	194	47	a	a	DT
cord-252443-lclxrwcm	194	48	novel	novel	JJ
cord-252443-lclxrwcm	194	49	heterosubtypic	heterosubtypic	NNP
cord-252443-lclxrwcm	194	50	influenza	influenza	NN
cord-252443-lclxrwcm	194	51	A	a	DT
cord-252443-lclxrwcm	194	52	vaccine	vaccine	NN
cord-252443-lclxrwcm	194	53	,	,	,
cord-252443-lclxrwcm	194	54	MVA	MVA	NNP
cord-252443-lclxrwcm	194	55	-	-	HYPH
cord-252443-lclxrwcm	194	56	NP+M1	NP+M1	NNP
cord-252443-lclxrwcm	194	57	T	t	NN
cord-252443-lclxrwcm	194	58	-	-	HYPH
cord-252443-lclxrwcm	194	59	cell	cell	NN
cord-252443-lclxrwcm	194	60	-	-	HYPH
cord-252443-lclxrwcm	194	61	inducing	induce	VBG
cord-252443-lclxrwcm	195	1	vaccineswhat	vaccineswhat	NNP
cord-252443-lclxrwcm	195	2	's	be	VBZ
cord-252443-lclxrwcm	195	3	the	the	DT
cord-252443-lclxrwcm	195	4	future	future	JJ
cord-252443-lclxrwcm	195	5	Viral	viral	JJ
cord-252443-lclxrwcm	195	6	vectors	vector	NNS
cord-252443-lclxrwcm	195	7	as	as	IN
cord-252443-lclxrwcm	195	8	vaccine	vaccine	NN
cord-252443-lclxrwcm	195	9	platforms	platform	NNS
cord-252443-lclxrwcm	195	10	:	:	:
cord-252443-lclxrwcm	196	1	deployment	deployment	NN
cord-252443-lclxrwcm	196	2	in	in	IN
cord-252443-lclxrwcm	196	3	sight	sight	NN
cord-252443-lclxrwcm	196	4	Kinetics	kinetic	NNS
cord-252443-lclxrwcm	196	5	of	of	IN
cord-252443-lclxrwcm	196	6	recombinant	recombinant	JJ
cord-252443-lclxrwcm	196	7	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	196	8	type	type	NN
cord-252443-lclxrwcm	196	9	5	5	CD
cord-252443-lclxrwcm	196	10	,	,	,
cord-252443-lclxrwcm	196	11	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	196	12	virus	virus	NN
cord-252443-lclxrwcm	196	13	,	,	,
cord-252443-lclxrwcm	196	14	modified	modify	VBN
cord-252443-lclxrwcm	196	15	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	196	16	ankara	ankara	NNP
cord-252443-lclxrwcm	196	17	virus	virus	NN
cord-252443-lclxrwcm	196	18	,	,	,
cord-252443-lclxrwcm	196	19	and	and	CC
cord-252443-lclxrwcm	196	20	DNA	dna	NN
cord-252443-lclxrwcm	196	21	antigen	antigen	NN
cord-252443-lclxrwcm	196	22	expression	expression	NN
cord-252443-lclxrwcm	196	23	in	in	IN
cord-252443-lclxrwcm	196	24	vivo	vivo	NN
cord-252443-lclxrwcm	196	25	and	and	CC
cord-252443-lclxrwcm	196	26	the	the	DT
cord-252443-lclxrwcm	196	27	induction	induction	NN
cord-252443-lclxrwcm	196	28	of	of	IN
cord-252443-lclxrwcm	196	29	memory	memory	NNP
cord-252443-lclxrwcm	196	30	T	t	NN
cord-252443-lclxrwcm	196	31	-	-	HYPH
cord-252443-lclxrwcm	196	32	lymphocyte	lymphocyte	NN
cord-252443-lclxrwcm	196	33	responses	response	NNS
cord-252443-lclxrwcm	196	34	Immunization	Immunization	NNP
cord-252443-lclxrwcm	196	35	of	of	IN
cord-252443-lclxrwcm	196	36	mice	mouse	NNS
cord-252443-lclxrwcm	196	37	with	with	IN
cord-252443-lclxrwcm	196	38	a	a	DT
cord-252443-lclxrwcm	196	39	recombinant	recombinant	JJ
cord-252443-lclxrwcm	196	40	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	196	41	vaccine	vaccine	NN
cord-252443-lclxrwcm	196	42	inhibits	inhibit	VBZ
cord-252443-lclxrwcm	196	43	the	the	DT
cord-252443-lclxrwcm	196	44	early	early	JJ
cord-252443-lclxrwcm	196	45	growth	growth	NN
cord-252443-lclxrwcm	196	46	of	of	IN
cord-252443-lclxrwcm	196	47	Mycobacterium	Mycobacterium	NNP
cord-252443-lclxrwcm	196	48	tuberculosis	tuberculosis	NN
cord-252443-lclxrwcm	196	49	after	after	IN
cord-252443-lclxrwcm	196	50	infection	infection	NN
cord-252443-lclxrwcm	196	51	Adenoviral	Adenoviral	NNP
cord-252443-lclxrwcm	196	52	vectors	vector	NNS
cord-252443-lclxrwcm	196	53	persist	persist	VBP
cord-252443-lclxrwcm	196	54	in	in	IN
cord-252443-lclxrwcm	196	55	vivo	vivo	NN
cord-252443-lclxrwcm	196	56	and	and	CC
cord-252443-lclxrwcm	196	57	maintain	maintain	VB
cord-252443-lclxrwcm	196	58	activated	activate	VBN
cord-252443-lclxrwcm	196	59	CD8	CD8	NNP
cord-252443-lclxrwcm	196	60	+	+	CC
cord-252443-lclxrwcm	196	61	T	T	NNP
cord-252443-lclxrwcm	196	62	cells	cell	NNS
cord-252443-lclxrwcm	196	63	:	:	:
cord-252443-lclxrwcm	196	64	implications	implication	NNS
cord-252443-lclxrwcm	196	65	for	for	IN
cord-252443-lclxrwcm	196	66	their	-PRON-	PRP$
cord-252443-lclxrwcm	196	67	use	use	NN
cord-252443-lclxrwcm	196	68	as	as	IN
cord-252443-lclxrwcm	196	69	vaccines	vaccine	NNS
cord-252443-lclxrwcm	196	70	Antigen	Antigen	NNP
cord-252443-lclxrwcm	196	71	depot	depot	NN
cord-252443-lclxrwcm	196	72	is	be	VBZ
cord-252443-lclxrwcm	196	73	not	not	RB
cord-252443-lclxrwcm	196	74	required	require	VBN
cord-252443-lclxrwcm	196	75	for	for	IN
cord-252443-lclxrwcm	196	76	alum	alum	NN
cord-252443-lclxrwcm	196	77	adjuvanticity	adjuvanticity	NNP
cord-252443-lclxrwcm	196	78	Low	low	JJ
cord-252443-lclxrwcm	196	79	antigen	antigen	NN
cord-252443-lclxrwcm	196	80	dose	dose	NN
cord-252443-lclxrwcm	196	81	favours	favour	VBZ
cord-252443-lclxrwcm	196	82	selection	selection	NN
cord-252443-lclxrwcm	196	83	of	of	IN
cord-252443-lclxrwcm	196	84	somatic	somatic	JJ
cord-252443-lclxrwcm	196	85	mutants	mutant	NNS
cord-252443-lclxrwcm	196	86	with	with	IN
cord-252443-lclxrwcm	196	87	hallmarks	hallmark	NNS
cord-252443-lclxrwcm	196	88	of	of	IN
cord-252443-lclxrwcm	196	89	antibody	antibody	NN
cord-252443-lclxrwcm	196	90	affinity	affinity	NN
cord-252443-lclxrwcm	196	91	maturation	maturation	NN
cord-252443-lclxrwcm	197	1	The	the	DT
cord-252443-lclxrwcm	197	2	descent	descent	NN
cord-252443-lclxrwcm	197	3	of	of	IN
cord-252443-lclxrwcm	197	4	memory	memory	NN
cord-252443-lclxrwcm	197	5	T	T	NNP
cord-252443-lclxrwcm	197	6	cells	cell	NNS
cord-252443-lclxrwcm	197	7	Differential	differential	JJ
cord-252443-lclxrwcm	197	8	effects	effect	NNS
cord-252443-lclxrwcm	197	9	of	of	IN
cord-252443-lclxrwcm	197	10	viral	viral	JJ
cord-252443-lclxrwcm	197	11	vectors	vector	NNS
cord-252443-lclxrwcm	197	12	on	on	IN
cord-252443-lclxrwcm	197	13	migratory	migratory	JJ
cord-252443-lclxrwcm	197	14	afferent	afferent	JJ
cord-252443-lclxrwcm	197	15	lymph	lymph	NN
cord-252443-lclxrwcm	197	16	dendritic	dendritic	JJ
cord-252443-lclxrwcm	197	17	cells	cell	NNS
cord-252443-lclxrwcm	197	18	in	in	IN
cord-252443-lclxrwcm	197	19	vitro	vitro	FW
cord-252443-lclxrwcm	197	20	predict	predict	VBP
cord-252443-lclxrwcm	197	21	enhanced	enhance	VBN
cord-252443-lclxrwcm	197	22	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	197	23	in	in	IN
cord-252443-lclxrwcm	197	24	vivo	vivo	NNP
cord-252443-lclxrwcm	197	25	Infection	infection	NN
cord-252443-lclxrwcm	197	26	of	of	IN
cord-252443-lclxrwcm	197	27	human	human	JJ
cord-252443-lclxrwcm	197	28	dendritic	dendritic	JJ
cord-252443-lclxrwcm	197	29	cells	cell	NNS
cord-252443-lclxrwcm	197	30	with	with	IN
cord-252443-lclxrwcm	197	31	recombinant	recombinant	JJ
cord-252443-lclxrwcm	197	32	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	197	33	virus	virus	NN
cord-252443-lclxrwcm	197	34	MVA	MVA	NNP
cord-252443-lclxrwcm	197	35	reveals	reveal	VBZ
cord-252443-lclxrwcm	197	36	general	general	JJ
cord-252443-lclxrwcm	197	37	persistence	persistence	NN
cord-252443-lclxrwcm	197	38	of	of	IN
cord-252443-lclxrwcm	197	39	viral	viral	JJ
cord-252443-lclxrwcm	197	40	early	early	JJ
cord-252443-lclxrwcm	197	41	transcription	transcription	NN
cord-252443-lclxrwcm	197	42	but	but	CC
cord-252443-lclxrwcm	197	43	distinct	distinct	JJ
cord-252443-lclxrwcm	197	44	maturation	maturation	NN
cord-252443-lclxrwcm	197	45	-	-	HYPH
cord-252443-lclxrwcm	197	46	dependent	dependent	JJ
cord-252443-lclxrwcm	197	47	cytopathogenicity	cytopathogenicity	NN
cord-252443-lclxrwcm	197	48	Long	long	JJ
cord-252443-lclxrwcm	197	49	-	-	HYPH
cord-252443-lclxrwcm	197	50	term	term	NN
cord-252443-lclxrwcm	197	51	thermostabilization	thermostabilization	NN
cord-252443-lclxrwcm	197	52	of	of	IN
cord-252443-lclxrwcm	197	53	live	live	JJ
cord-252443-lclxrwcm	197	54	poxviral	poxviral	NNP
cord-252443-lclxrwcm	197	55	and	and	CC
cord-252443-lclxrwcm	197	56	adenoviral	adenoviral	JJ
cord-252443-lclxrwcm	197	57	vaccine	vaccine	NN
cord-252443-lclxrwcm	197	58	vectors	vector	NNS
cord-252443-lclxrwcm	197	59	at	at	IN
cord-252443-lclxrwcm	197	60	supraphysiological	supraphysiological	JJ
cord-252443-lclxrwcm	197	61	temperatures	temperature	NNS
cord-252443-lclxrwcm	197	62	in	in	IN
cord-252443-lclxrwcm	197	63	carbohydrate	carbohydrate	NN
cord-252443-lclxrwcm	197	64	glass	glass	NN
cord-252443-lclxrwcm	197	65	Replicating	replicate	VBG
cord-252443-lclxrwcm	197	66	and	and	CC
cord-252443-lclxrwcm	197	67	nonreplicating	nonreplicate	VBG
cord-252443-lclxrwcm	197	68	viral	viral	JJ
cord-252443-lclxrwcm	197	69	vectors	vector	NNS
cord-252443-lclxrwcm	197	70	for	for	IN
cord-252443-lclxrwcm	197	71	vaccine	vaccine	NN
cord-252443-lclxrwcm	197	72	development	development	NN
cord-252443-lclxrwcm	197	73	Adenovirus	Adenovirus	NNP
cord-252443-lclxrwcm	197	74	infections	infection	NNS
cord-252443-lclxrwcm	197	75	in	in	IN
cord-252443-lclxrwcm	197	76	the	the	DT
cord-252443-lclxrwcm	197	77	immunocompromised	immunocompromised	JJ
cord-252443-lclxrwcm	197	78	host	host	NN
cord-252443-lclxrwcm	197	79	Recombinant	recombinant	JJ
cord-252443-lclxrwcm	197	80	vectors	vector	NNS
cord-252443-lclxrwcm	197	81	as	as	IN
cord-252443-lclxrwcm	197	82	influenza	influenza	NN
cord-252443-lclxrwcm	197	83	vaccines	vaccine	NNS
cord-252443-lclxrwcm	197	84	Recombinant	recombinant	JJ
cord-252443-lclxrwcm	197	85	viruses	virus	NNS
cord-252443-lclxrwcm	197	86	as	as	IN
cord-252443-lclxrwcm	197	87	vaccines	vaccine	NNS
cord-252443-lclxrwcm	197	88	against	against	IN
cord-252443-lclxrwcm	197	89	viral	viral	JJ
cord-252443-lclxrwcm	197	90	diseases	disease	NNS
cord-252443-lclxrwcm	197	91	.	.	.
cord-252443-lclxrwcm	198	1	Braz	Braz	NNP
cord-252443-lclxrwcm	198	2	New	New	NNP
cord-252443-lclxrwcm	198	3	insights	insight	NNS
cord-252443-lclxrwcm	198	4	on	on	IN
cord-252443-lclxrwcm	198	5	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	198	6	as	as	IN
cord-252443-lclxrwcm	198	7	vaccine	vaccine	NN
cord-252443-lclxrwcm	198	8	vectors	vector	NNS
cord-252443-lclxrwcm	198	9	Chimpanzee	chimpanzee	NN
cord-252443-lclxrwcm	198	10	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	198	11	antibodies	antibody	NNS
cord-252443-lclxrwcm	198	12	in	in	IN
cord-252443-lclxrwcm	198	13	humans	human	NNS
cord-252443-lclxrwcm	198	14	,	,	,
cord-252443-lclxrwcm	198	15	sub	sub	JJ
cord-252443-lclxrwcm	198	16	-	-	JJ
cord-252443-lclxrwcm	198	17	Saharan	saharan	JJ
cord-252443-lclxrwcm	198	18	Africa	Africa	NNP
cord-252443-lclxrwcm	198	19	Prevalence	prevalence	NN
cord-252443-lclxrwcm	198	20	of	of	IN
cord-252443-lclxrwcm	198	21	serum	serum	NN
cord-252443-lclxrwcm	198	22	neutralizing	neutralize	VBG
cord-252443-lclxrwcm	198	23	antibodies	antibody	NNS
cord-252443-lclxrwcm	198	24	against	against	IN
cord-252443-lclxrwcm	198	25	chimpanzee	chimpanzee	NN
cord-252443-lclxrwcm	198	26	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	198	27	63	63	CD
cord-252443-lclxrwcm	198	28	and	and	CC
cord-252443-lclxrwcm	198	29	human	human	JJ
cord-252443-lclxrwcm	198	30	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	198	31	5	5	CD
cord-252443-lclxrwcm	198	32	in	in	IN
cord-252443-lclxrwcm	198	33	Kenyan	kenyan	JJ
cord-252443-lclxrwcm	198	34	Children	Children	NNP
cord-252443-lclxrwcm	198	35	,	,	,
cord-252443-lclxrwcm	198	36	in	in	IN
cord-252443-lclxrwcm	198	37	the	the	DT
cord-252443-lclxrwcm	198	38	context	context	NN
cord-252443-lclxrwcm	198	39	of	of	IN
cord-252443-lclxrwcm	198	40	vaccine	vaccine	NN
cord-252443-lclxrwcm	198	41	vector	vector	NN
cord-252443-lclxrwcm	198	42	efficacy	efficacy	NN
cord-252443-lclxrwcm	198	43	Vaccine	vaccine	NN
cord-252443-lclxrwcm	198	44	vectors	vector	NNS
cord-252443-lclxrwcm	198	45	derived	derive	VBN
cord-252443-lclxrwcm	198	46	from	from	IN
cord-252443-lclxrwcm	198	47	a	a	DT
cord-252443-lclxrwcm	198	48	large	large	JJ
cord-252443-lclxrwcm	198	49	collection	collection	NN
cord-252443-lclxrwcm	198	50	of	of	IN
cord-252443-lclxrwcm	198	51	simian	simian	JJ
cord-252443-lclxrwcm	198	52	adenoviruses	adenovirus	NNS
cord-252443-lclxrwcm	198	53	induce	induce	VBP
cord-252443-lclxrwcm	198	54	potent	potent	JJ
cord-252443-lclxrwcm	198	55	cellular	cellular	JJ
cord-252443-lclxrwcm	198	56	immunity	immunity	NN
cord-252443-lclxrwcm	198	57	across	across	IN
cord-252443-lclxrwcm	198	58	multiple	multiple	JJ
cord-252443-lclxrwcm	198	59	species	specie	NNS
cord-252443-lclxrwcm	198	60	Protection	protection	NN
cord-252443-lclxrwcm	198	61	of	of	IN
cord-252443-lclxrwcm	198	62	mice	mouse	NNS
cord-252443-lclxrwcm	198	63	and	and	CC
cord-252443-lclxrwcm	198	64	poultry	poultry	NN
cord-252443-lclxrwcm	198	65	from	from	IN
cord-252443-lclxrwcm	198	66	lethal	lethal	JJ
cord-252443-lclxrwcm	198	67	H5N1	H5N1	NNP
cord-252443-lclxrwcm	198	68	avian	avian	JJ
cord-252443-lclxrwcm	198	69	influenza	influenza	NN
cord-252443-lclxrwcm	198	70	virus	virus	NN
cord-252443-lclxrwcm	198	71	through	through	IN
cord-252443-lclxrwcm	198	72	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	198	73	-	-	HYPH
cord-252443-lclxrwcm	198	74	based	base	VBN
cord-252443-lclxrwcm	198	75	immunization	immunization	NN
cord-252443-lclxrwcm	198	76	Protective	protective	JJ
cord-252443-lclxrwcm	198	77	avian	avian	JJ
cord-252443-lclxrwcm	198	78	influenza	influenza	NN
cord-252443-lclxrwcm	198	79	in	in	IN
cord-252443-lclxrwcm	198	80	ovo	ovo	NNP
cord-252443-lclxrwcm	198	81	vaccination	vaccination	NN
cord-252443-lclxrwcm	198	82	with	with	IN
cord-252443-lclxrwcm	198	83	non	non	JJ
cord-252443-lclxrwcm	198	84	-	-	JJ
cord-252443-lclxrwcm	198	85	replicating	replicating	JJ
cord-252443-lclxrwcm	198	86	human	human	JJ
cord-252443-lclxrwcm	198	87	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	198	88	vector	vector	NN
cord-252443-lclxrwcm	198	89	New	new	JJ
cord-252443-lclxrwcm	198	90	pre	pre	JJ
cord-252443-lclxrwcm	198	91	-	-	JJ
cord-252443-lclxrwcm	198	92	pandemic	pandemic	JJ
cord-252443-lclxrwcm	198	93	influenza	influenza	NN
cord-252443-lclxrwcm	198	94	vaccines	vaccine	NNS
cord-252443-lclxrwcm	198	95	:	:	:
cord-252443-lclxrwcm	198	96	an	an	DT
cord-252443-lclxrwcm	198	97	egg	egg	NN
cord-252443-lclxrwcm	198	98	-	-	HYPH
cord-252443-lclxrwcm	198	99	and	and	CC
cord-252443-lclxrwcm	198	100	adjuvantindependent	adjuvantindependent	JJ
cord-252443-lclxrwcm	198	101	human	human	JJ
cord-252443-lclxrwcm	198	102	adenoviral	adenoviral	NNP
cord-252443-lclxrwcm	198	103	vector	vector	NN
cord-252443-lclxrwcm	198	104	strategy	strategy	NN
cord-252443-lclxrwcm	198	105	induces	induce	VBZ
cord-252443-lclxrwcm	198	106	long	long	RB
cord-252443-lclxrwcm	198	107	-	-	HYPH
cord-252443-lclxrwcm	198	108	lasting	last	VBG
cord-252443-lclxrwcm	198	109	protective	protective	JJ
cord-252443-lclxrwcm	198	110	immune	immune	JJ
cord-252443-lclxrwcm	198	111	responses	response	NNS
cord-252443-lclxrwcm	198	112	in	in	IN
cord-252443-lclxrwcm	198	113	mice	mouse	NNS
cord-252443-lclxrwcm	198	114	Antigen	Antigen	NNP
cord-252443-lclxrwcm	198	115	delivery	delivery	NN
cord-252443-lclxrwcm	198	116	systems	system	NNS
cord-252443-lclxrwcm	198	117	for	for	IN
cord-252443-lclxrwcm	198	118	veterinary	veterinary	JJ
cord-252443-lclxrwcm	198	119	vaccine	vaccine	NN
cord-252443-lclxrwcm	198	120	development	development	NN
cord-252443-lclxrwcm	198	121	:	:	:
cord-252443-lclxrwcm	198	122	viral	viral	JJ
cord-252443-lclxrwcm	198	123	-	-	HYPH
cord-252443-lclxrwcm	198	124	vector	vector	NN
cord-252443-lclxrwcm	198	125	based	base	VBN
cord-252443-lclxrwcm	198	126	delivery	delivery	NN
cord-252443-lclxrwcm	198	127	systems	system	NNS
cord-252443-lclxrwcm	198	128	Introduction	introduction	NN
cord-252443-lclxrwcm	198	129	of	of	IN
cord-252443-lclxrwcm	198	130	foreign	foreign	JJ
cord-252443-lclxrwcm	198	131	DNA	dna	NN
cord-252443-lclxrwcm	198	132	into	into	IN
cord-252443-lclxrwcm	198	133	the	the	DT
cord-252443-lclxrwcm	198	134	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	198	135	virus	virus	NN
cord-252443-lclxrwcm	198	136	genome	genome	VBN
cord-252443-lclxrwcm	198	137	by	by	IN
cord-252443-lclxrwcm	198	138	in	in	FW
cord-252443-lclxrwcm	198	139	vitro	vitro	FW
cord-252443-lclxrwcm	198	140	ligation	ligation	NN
cord-252443-lclxrwcm	198	141	:	:	:
cord-252443-lclxrwcm	198	142	recombination	recombination	NN
cord-252443-lclxrwcm	198	143	-	-	HYPH
cord-252443-lclxrwcm	198	144	independent	independent	JJ
cord-252443-lclxrwcm	198	145	selectable	selectable	JJ
cord-252443-lclxrwcm	198	146	cloning	cloning	NN
cord-252443-lclxrwcm	198	147	vectors	vector	NNS
cord-252443-lclxrwcm	198	148	Construction	construction	NN
cord-252443-lclxrwcm	198	149	of	of	IN
cord-252443-lclxrwcm	198	150	recombinant	recombinant	JJ
cord-252443-lclxrwcm	198	151	fowlpox	fowlpox	NN
cord-252443-lclxrwcm	198	152	viruses	virus	NNS
cord-252443-lclxrwcm	198	153	carrying	carry	VBG
cord-252443-lclxrwcm	198	154	multiple	multiple	JJ
cord-252443-lclxrwcm	198	155	vaccine	vaccine	NN
cord-252443-lclxrwcm	198	156	antigens	antigen	NNS
cord-252443-lclxrwcm	198	157	and	and	CC
cord-252443-lclxrwcm	198	158	immunomodulatory	immunomodulatory	JJ
cord-252443-lclxrwcm	198	159	molecules	molecule	NNS
cord-252443-lclxrwcm	198	160	Recombinant	recombinant	JJ
cord-252443-lclxrwcm	198	161	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	198	162	virus	virus	NN
cord-252443-lclxrwcm	198	163	:	:	:
cord-252443-lclxrwcm	198	164	immunization	immunization	NN
cord-252443-lclxrwcm	198	165	against	against	IN
cord-252443-lclxrwcm	198	166	multiple	multiple	JJ
cord-252443-lclxrwcm	198	167	pathogens	pathogen	NNS
cord-252443-lclxrwcm	199	1	Nonreplicating	nonreplicate	VBG
cord-252443-lclxrwcm	199	2	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	199	3	vector	vector	NN
cord-252443-lclxrwcm	199	4	efficiently	efficiently	RB
cord-252443-lclxrwcm	199	5	expresses	express	VBZ
cord-252443-lclxrwcm	199	6	recombinant	recombinant	JJ
cord-252443-lclxrwcm	199	7	genes	gene	NNS
cord-252443-lclxrwcm	199	8	Diagnosis	Diagnosis	NNP
cord-252443-lclxrwcm	199	9	and	and	CC
cord-252443-lclxrwcm	199	10	management	management	NN
cord-252443-lclxrwcm	199	11	of	of	IN
cord-252443-lclxrwcm	199	12	smallpox	smallpox	NN
cord-252443-lclxrwcm	200	1	Enhanced	enhanced	JJ
cord-252443-lclxrwcm	200	2	T	t	NN
cord-252443-lclxrwcm	200	3	cell	cell	NN
cord-252443-lclxrwcm	200	4	-	-	HYPH
cord-252443-lclxrwcm	200	5	mediated	mediate	VBN
cord-252443-lclxrwcm	200	6	protection	protection	NN
cord-252443-lclxrwcm	200	7	against	against	IN
cord-252443-lclxrwcm	200	8	malaria	malaria	NN
cord-252443-lclxrwcm	200	9	in	in	IN
cord-252443-lclxrwcm	200	10	human	human	JJ
cord-252443-lclxrwcm	200	11	challenges	challenge	NNS
cord-252443-lclxrwcm	200	12	by	by	IN
cord-252443-lclxrwcm	200	13	using	use	VBG
cord-252443-lclxrwcm	200	14	the	the	DT
cord-252443-lclxrwcm	200	15	recombinant	recombinant	JJ
cord-252443-lclxrwcm	200	16	poxviruses	poxviruses	NNP
cord-252443-lclxrwcm	200	17	FP9	FP9	NNP
cord-252443-lclxrwcm	200	18	and	and	CC
cord-252443-lclxrwcm	200	19	modified	modify	VBN
cord-252443-lclxrwcm	200	20	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	200	21	virus	virus	NN
cord-252443-lclxrwcm	201	1	Ankara	Ankara	NNP
cord-252443-lclxrwcm	201	2	A	A	NNP
cord-252443-lclxrwcm	201	3	phase	phase	NN
cord-252443-lclxrwcm	201	4	2b	2b	CD
cord-252443-lclxrwcm	201	5	randomised	randomised	JJ
cord-252443-lclxrwcm	201	6	trial	trial	NN
cord-252443-lclxrwcm	201	7	of	of	IN
cord-252443-lclxrwcm	201	8	the	the	DT
cord-252443-lclxrwcm	201	9	candidate	candidate	NN
cord-252443-lclxrwcm	201	10	malaria	malaria	NN
cord-252443-lclxrwcm	201	11	vaccines	vaccine	NNS
cord-252443-lclxrwcm	201	12	FP9	fp9	VBP
cord-252443-lclxrwcm	201	13	ME	ME	NNP
cord-252443-lclxrwcm	201	14	-	-	HYPH
cord-252443-lclxrwcm	201	15	TRAP	trap	NN
cord-252443-lclxrwcm	201	16	and	and	CC
cord-252443-lclxrwcm	201	17	MVA	MVA	NNP
cord-252443-lclxrwcm	201	18	ME	ME	NNP
cord-252443-lclxrwcm	201	19	-	-	HYPH
cord-252443-lclxrwcm	201	20	TRAP	trap	NN
cord-252443-lclxrwcm	201	21	among	among	IN
cord-252443-lclxrwcm	201	22	children	child	NNS
cord-252443-lclxrwcm	201	23	in	in	IN
cord-252443-lclxrwcm	201	24	Kenya	Kenya	NNP
cord-252443-lclxrwcm	201	25	A	A	NNP
cord-252443-lclxrwcm	201	26	Phase	phase	NN
cord-252443-lclxrwcm	202	1	I	-PRON-	PRP
cord-252443-lclxrwcm	202	2	study	study	VBP
cord-252443-lclxrwcm	202	3	evaluating	evaluate	VBG
cord-252443-lclxrwcm	202	4	the	the	DT
cord-252443-lclxrwcm	202	5	safety	safety	NN
cord-252443-lclxrwcm	202	6	and	and	CC
cord-252443-lclxrwcm	202	7	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	202	8	of	of	IN
cord-252443-lclxrwcm	202	9	MVA85A	MVA85A	NNP
cord-252443-lclxrwcm	202	10	,	,	,
cord-252443-lclxrwcm	202	11	a	a	DT
cord-252443-lclxrwcm	202	12	candidate	candidate	NN
cord-252443-lclxrwcm	202	13	TB	TB	NNP
cord-252443-lclxrwcm	202	14	vaccine	vaccine	NN
cord-252443-lclxrwcm	202	15	,	,	,
cord-252443-lclxrwcm	202	16	in	in	IN
cord-252443-lclxrwcm	202	17	HIV	HIV	NNP
cord-252443-lclxrwcm	202	18	-	-	HYPH
cord-252443-lclxrwcm	202	19	infected	infect	VBN
cord-252443-lclxrwcm	202	20	adults	adult	NNS
cord-252443-lclxrwcm	202	21	Biodistribution	Biodistribution	NNP
cord-252443-lclxrwcm	202	22	and	and	CC
cord-252443-lclxrwcm	202	23	persistence	persistence	NN
cord-252443-lclxrwcm	202	24	of	of	IN
cord-252443-lclxrwcm	202	25	an	an	DT
cord-252443-lclxrwcm	202	26	MVA	MVA	NNP
cord-252443-lclxrwcm	202	27	-	-	HYPH
cord-252443-lclxrwcm	202	28	vectored	vectore	VBN
cord-252443-lclxrwcm	202	29	candidate	candidate	NN
cord-252443-lclxrwcm	202	30	HIV	HIV	NNP
cord-252443-lclxrwcm	202	31	vaccine	vaccine	NN
cord-252443-lclxrwcm	202	32	in	in	IN
cord-252443-lclxrwcm	202	33	SIV	SIV	NNP
cord-252443-lclxrwcm	202	34	-	-	HYPH
cord-252443-lclxrwcm	202	35	infected	infect	VBN
cord-252443-lclxrwcm	202	36	rhesus	rhesus	NN
cord-252443-lclxrwcm	202	37	macaques	macaque	NNS
cord-252443-lclxrwcm	202	38	and	and	CC
cord-252443-lclxrwcm	202	39	SCID	SCID	NNP
cord-252443-lclxrwcm	202	40	mice	mouse	NNS
cord-252443-lclxrwcm	203	1	Attenuated	attenuated	JJ
cord-252443-lclxrwcm	203	2	modified	modify	VBN
cord-252443-lclxrwcm	203	3	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	203	4	virus	virus	NN
cord-252443-lclxrwcm	203	5	Ankara	Ankara	NNP
cord-252443-lclxrwcm	203	6	can	can	MD
cord-252443-lclxrwcm	203	7	be	be	VB
cord-252443-lclxrwcm	203	8	used	use	VBN
cord-252443-lclxrwcm	203	9	as	as	IN
cord-252443-lclxrwcm	203	10	an	an	DT
cord-252443-lclxrwcm	203	11	immunizing	immunize	VBG
cord-252443-lclxrwcm	203	12	agent	agent	NN
cord-252443-lclxrwcm	203	13	under	under	IN
cord-252443-lclxrwcm	203	14	conditions	condition	NNS
cord-252443-lclxrwcm	203	15	of	of	IN
cord-252443-lclxrwcm	203	16	preexisting	preexist	VBG
cord-252443-lclxrwcm	203	17	immunity	immunity	NN
cord-252443-lclxrwcm	203	18	to	to	IN
cord-252443-lclxrwcm	203	19	the	the	DT
cord-252443-lclxrwcm	203	20	vector	vector	NN
cord-252443-lclxrwcm	203	21	Candidate	Candidate	NNP
cord-252443-lclxrwcm	203	22	influenza	influenza	NN
cord-252443-lclxrwcm	203	23	vaccines	vaccine	NNS
cord-252443-lclxrwcm	203	24	based	base	VBN
cord-252443-lclxrwcm	203	25	on	on	IN
cord-252443-lclxrwcm	203	26	recombinant	recombinant	JJ
cord-252443-lclxrwcm	203	27	modified	modify	VBN
cord-252443-lclxrwcm	203	28	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	203	29	virus	virus	NN
cord-252443-lclxrwcm	203	30	Ankara	Ankara	NNP
cord-252443-lclxrwcm	203	31	Clinical	Clinical	NNP
cord-252443-lclxrwcm	203	32	assessment	assessment	NN
cord-252443-lclxrwcm	203	33	of	of	IN
cord-252443-lclxrwcm	203	34	a	a	DT
cord-252443-lclxrwcm	203	35	recombinant	recombinant	JJ
cord-252443-lclxrwcm	203	36	simian	simian	JJ
cord-252443-lclxrwcm	203	37	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	203	38	ChAd63	chad63	NN
cord-252443-lclxrwcm	203	39	:	:	:
cord-252443-lclxrwcm	204	1	a	a	DT
cord-252443-lclxrwcm	204	2	potent	potent	JJ
cord-252443-lclxrwcm	204	3	new	new	JJ
cord-252443-lclxrwcm	204	4	vaccine	vaccine	NN
cord-252443-lclxrwcm	204	5	vector	vector	NN
cord-252443-lclxrwcm	204	6	Phase	phase	NN
cord-252443-lclxrwcm	204	7	1	1	CD
cord-252443-lclxrwcm	204	8	evaluation	evaluation	NN
cord-252443-lclxrwcm	204	9	of	of	IN
cord-252443-lclxrwcm	204	10	3	3	CD
cord-252443-lclxrwcm	204	11	highly	highly	RB
cord-252443-lclxrwcm	204	12	immunogenic	immunogenic	JJ
cord-252443-lclxrwcm	204	13	prime	prime	JJ
cord-252443-lclxrwcm	204	14	-	-	HYPH
cord-252443-lclxrwcm	204	15	boost	boost	NN
cord-252443-lclxrwcm	204	16	regimens	regimen	NNS
cord-252443-lclxrwcm	204	17	,	,	,
cord-252443-lclxrwcm	204	18	including	include	VBG
cord-252443-lclxrwcm	204	19	a	a	DT
cord-252443-lclxrwcm	204	20	12-month	12-month	JJ
cord-252443-lclxrwcm	204	21	reboosting	rebooste	VBG
cord-252443-lclxrwcm	204	22	vaccination	vaccination	NN
cord-252443-lclxrwcm	204	23	,	,	,
cord-252443-lclxrwcm	204	24	for	for	IN
cord-252443-lclxrwcm	204	25	malaria	malaria	NN
cord-252443-lclxrwcm	204	26	vaccination	vaccination	NN
cord-252443-lclxrwcm	204	27	in	in	IN
cord-252443-lclxrwcm	204	28	Gambian	gambian	JJ
cord-252443-lclxrwcm	204	29	men	man	NNS
cord-252443-lclxrwcm	204	30	Differential	Differential	NNP
cord-252443-lclxrwcm	204	31	CD4	CD4	NNP
cord-252443-lclxrwcm	204	32	+	+	CC
cord-252443-lclxrwcm	204	33	versus	versus	IN
cord-252443-lclxrwcm	204	34	CD8	CD8	NNP
cord-252443-lclxrwcm	204	35	+	+	CC
cord-252443-lclxrwcm	204	36	T	t	NN
cord-252443-lclxrwcm	204	37	-	-	HYPH
cord-252443-lclxrwcm	204	38	cell	cell	NN
cord-252443-lclxrwcm	204	39	responses	response	NNS
cord-252443-lclxrwcm	204	40	elicited	elicit	VBN
cord-252443-lclxrwcm	204	41	by	by	IN
cord-252443-lclxrwcm	204	42	different	different	JJ
cord-252443-lclxrwcm	204	43	poxvirus	poxvirus	NNP
cord-252443-lclxrwcm	204	44	-	-	HYPH
cord-252443-lclxrwcm	204	45	based	base	VBN
cord-252443-lclxrwcm	204	46	human	human	JJ
cord-252443-lclxrwcm	204	47	immunodeficiency	immunodeficiency	NN
cord-252443-lclxrwcm	204	48	virus	virus	NN
cord-252443-lclxrwcm	204	49	type	type	NN
cord-252443-lclxrwcm	204	50	1	1	CD
cord-252443-lclxrwcm	204	51	vaccine	vaccine	NN
cord-252443-lclxrwcm	204	52	candidates	candidate	NNS
cord-252443-lclxrwcm	204	53	provide	provide	VBP
cord-252443-lclxrwcm	204	54	comparable	comparable	JJ
cord-252443-lclxrwcm	204	55	efficacies	efficacy	NNS
cord-252443-lclxrwcm	204	56	in	in	IN
cord-252443-lclxrwcm	204	57	primates	primate	NNS
cord-252443-lclxrwcm	204	58	Cross	Cross	NNP
cord-252443-lclxrwcm	204	59	-	-	NN
cord-252443-lclxrwcm	204	60	priming	priming	NN
cord-252443-lclxrwcm	204	61	of	of	IN
cord-252443-lclxrwcm	204	62	cytotoxic	cytotoxic	JJ
cord-252443-lclxrwcm	204	63	T	t	NN
cord-252443-lclxrwcm	204	64	cells	cell	NNS
cord-252443-lclxrwcm	204	65	dictates	dictate	VBZ
cord-252443-lclxrwcm	204	66	antigen	antigen	NN
cord-252443-lclxrwcm	204	67	requisites	requisite	NNS
cord-252443-lclxrwcm	204	68	for	for	IN
cord-252443-lclxrwcm	204	69	modified	modify	VBN
cord-252443-lclxrwcm	204	70	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	204	71	virus	virus	NN
cord-252443-lclxrwcm	204	72	Ankara	Ankara	NNP
cord-252443-lclxrwcm	204	73	vector	vector	NN
cord-252443-lclxrwcm	204	74	vaccines	vaccine	NNS
cord-252443-lclxrwcm	204	75	Development	development	NN
cord-252443-lclxrwcm	204	76	and	and	CC
cord-252443-lclxrwcm	204	77	use	use	NN
cord-252443-lclxrwcm	204	78	of	of	IN
cord-252443-lclxrwcm	204	79	fowlpox	fowlpox	NNP
cord-252443-lclxrwcm	204	80	vectored	vectore	VBN
cord-252443-lclxrwcm	204	81	vaccines	vaccine	NNS
cord-252443-lclxrwcm	204	82	for	for	IN
cord-252443-lclxrwcm	204	83	avian	avian	JJ
cord-252443-lclxrwcm	204	84	influenza	influenza	NN
cord-252443-lclxrwcm	204	85	Recombinant	recombinant	JJ
cord-252443-lclxrwcm	204	86	modified	modify	VBN
cord-252443-lclxrwcm	204	87	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	204	88	virus	virus	NN
cord-252443-lclxrwcm	204	89	Ankara	Ankara	NNP
cord-252443-lclxrwcm	204	90	expressing	express	VBG
cord-252443-lclxrwcm	204	91	the	the	DT
cord-252443-lclxrwcm	204	92	hemagglutinin	hemagglutinin	NN
cord-252443-lclxrwcm	204	93	gene	gene	NN
cord-252443-lclxrwcm	204	94	confers	confer	VBZ
cord-252443-lclxrwcm	204	95	protection	protection	NN
cord-252443-lclxrwcm	204	96	against	against	IN
cord-252443-lclxrwcm	204	97	homologous	homologous	JJ
cord-252443-lclxrwcm	204	98	and	and	CC
cord-252443-lclxrwcm	204	99	heterologous	heterologous	JJ
cord-252443-lclxrwcm	204	100	H5N1	H5N1	NNP
cord-252443-lclxrwcm	204	101	influenza	influenza	NN
cord-252443-lclxrwcm	204	102	virus	virus	NN
cord-252443-lclxrwcm	204	103	infections	infection	NNS
cord-252443-lclxrwcm	204	104	in	in	IN
cord-252443-lclxrwcm	204	105	macaques	macaque	NNS
cord-252443-lclxrwcm	204	106	Preclinical	preclinical	JJ
cord-252443-lclxrwcm	204	107	evaluation	evaluation	NN
cord-252443-lclxrwcm	204	108	of	of	IN
cord-252443-lclxrwcm	204	109	a	a	DT
cord-252443-lclxrwcm	204	110	modified	modify	VBN
cord-252443-lclxrwcm	204	111	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	204	112	virus	virus	NN
cord-252443-lclxrwcm	204	113	Ankara	Ankara	NNP
cord-252443-lclxrwcm	204	114	(	(	-LRB-
cord-252443-lclxrwcm	204	115	MVA)-based	mva)-base	VBN
cord-252443-lclxrwcm	204	116	vaccine	vaccine	NN
cord-252443-lclxrwcm	204	117	against	against	IN
cord-252443-lclxrwcm	204	118	influenza	influenza	NN
cord-252443-lclxrwcm	204	119	A	A	NNP
cord-252443-lclxrwcm	204	120	/	/	SYM
cord-252443-lclxrwcm	204	121	H5N1	H5N1	NNP
cord-252443-lclxrwcm	204	122	viruses	virus	NNS
cord-252443-lclxrwcm	205	1	MVA	MVA	NNP
cord-252443-lclxrwcm	205	2	-	-	HYPH
cord-252443-lclxrwcm	205	3	based	base	VBN
cord-252443-lclxrwcm	205	4	H5N1	H5N1	NNP
cord-252443-lclxrwcm	205	5	vaccine	vaccine	NN
cord-252443-lclxrwcm	205	6	affords	afford	VBZ
cord-252443-lclxrwcm	205	7	cross	cross	NN
cord-252443-lclxrwcm	205	8	-	-	JJ
cord-252443-lclxrwcm	205	9	clade	clade	JJ
cord-252443-lclxrwcm	205	10	protection	protection	NN
cord-252443-lclxrwcm	205	11	in	in	IN
cord-252443-lclxrwcm	205	12	mice	mouse	NNS
cord-252443-lclxrwcm	205	13	against	against	IN
cord-252443-lclxrwcm	205	14	influenza	influenza	NNP
cord-252443-lclxrwcm	205	15	A	A	NNP
cord-252443-lclxrwcm	205	16	/	/	SYM
cord-252443-lclxrwcm	205	17	H5N1	H5N1	NNP
cord-252443-lclxrwcm	205	18	viruses	virus	NNS
cord-252443-lclxrwcm	205	19	at	at	IN
cord-252443-lclxrwcm	205	20	low	low	JJ
cord-252443-lclxrwcm	205	21	doses	dose	NNS
cord-252443-lclxrwcm	205	22	and	and	CC
cord-252443-lclxrwcm	205	23	after	after	IN
cord-252443-lclxrwcm	205	24	single	single	JJ
cord-252443-lclxrwcm	205	25	immunization	immunization	NN
cord-252443-lclxrwcm	205	26	Vectors	vector	NNS
cord-252443-lclxrwcm	205	27	based	base	VBN
cord-252443-lclxrwcm	205	28	on	on	IN
cord-252443-lclxrwcm	205	29	modified	modify	VBN
cord-252443-lclxrwcm	205	30	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	205	31	Ankara	Ankara	NNP
cord-252443-lclxrwcm	205	32	expressing	express	VBG
cord-252443-lclxrwcm	205	33	influenza	influenza	NN
cord-252443-lclxrwcm	205	34	H5N1	H5N1	NNP
cord-252443-lclxrwcm	205	35	hemagglutinin	hemagglutinin	NNS
cord-252443-lclxrwcm	205	36	induce	induce	VBP
cord-252443-lclxrwcm	205	37	substantial	substantial	JJ
cord-252443-lclxrwcm	205	38	crossclade	crossclade	NN
cord-252443-lclxrwcm	205	39	protective	protective	JJ
cord-252443-lclxrwcm	205	40	immunity	immunity	NN
cord-252443-lclxrwcm	205	41	Vaccinia	Vaccinia	NNP
cord-252443-lclxrwcm	205	42	virus	virus	NN
cord-252443-lclxrwcm	205	43	-	-	HYPH
cord-252443-lclxrwcm	205	44	based	base	VBN
cord-252443-lclxrwcm	205	45	multivalent	multivalent	JJ
cord-252443-lclxrwcm	205	46	H5N1	H5N1	NNP
cord-252443-lclxrwcm	205	47	avian	avian	JJ
cord-252443-lclxrwcm	205	48	influenza	influenza	NN
cord-252443-lclxrwcm	205	49	vaccines	vaccine	NNS
cord-252443-lclxrwcm	205	50	adjuvanted	adjuvante	VBN
cord-252443-lclxrwcm	205	51	with	with	IN
cord-252443-lclxrwcm	205	52	IL-15	IL-15	NNP
cord-252443-lclxrwcm	205	53	confer	confer	VB
cord-252443-lclxrwcm	205	54	sterile	sterile	JJ
cord-252443-lclxrwcm	205	55	cross	cross	JJ
cord-252443-lclxrwcm	205	56	-	-	JJ
cord-252443-lclxrwcm	205	57	clade	clade	JJ
cord-252443-lclxrwcm	205	58	protection	protection	NN
cord-252443-lclxrwcm	205	59	in	in	IN
cord-252443-lclxrwcm	205	60	mice	mouse	NNS
cord-252443-lclxrwcm	206	1	A	a	DT
cord-252443-lclxrwcm	206	2	preliminary	preliminary	JJ
cord-252443-lclxrwcm	206	3	assessment	assessment	NN
cord-252443-lclxrwcm	206	4	of	of	IN
cord-252443-lclxrwcm	206	5	the	the	DT
cord-252443-lclxrwcm	206	6	efficacy	efficacy	NN
cord-252443-lclxrwcm	206	7	of	of	IN
cord-252443-lclxrwcm	206	8	a	a	DT
cord-252443-lclxrwcm	206	9	T	T	NNP
cord-252443-lclxrwcm	206	10	cell	cell	NN
cord-252443-lclxrwcm	206	11	-	-	HYPH
cord-252443-lclxrwcm	206	12	based	base	VBN
cord-252443-lclxrwcm	206	13	influenza	influenza	NN
cord-252443-lclxrwcm	206	14	vaccine	vaccine	NN
cord-252443-lclxrwcm	206	15	,	,	,
cord-252443-lclxrwcm	206	16	MVA	MVA	NNP
cord-252443-lclxrwcm	206	17	-	-	HYPH
cord-252443-lclxrwcm	206	18	NP+M1	NP+M1	NNP
cord-252443-lclxrwcm	206	19	,	,	,
cord-252443-lclxrwcm	206	20	in	in	IN
cord-252443-lclxrwcm	206	21	humans	human	NNS
cord-252443-lclxrwcm	206	22	Attenuation	Attenuation	NNP
cord-252443-lclxrwcm	206	23	of	of	IN
cord-252443-lclxrwcm	206	24	simian	simian	JJ
cord-252443-lclxrwcm	206	25	immunodeficiency	immunodeficiency	NN
cord-252443-lclxrwcm	206	26	virus	virus	NN
cord-252443-lclxrwcm	206	27	SIVmac239	SIVmac239	NNP
cord-252443-lclxrwcm	206	28	infection	infection	NN
cord-252443-lclxrwcm	206	29	by	by	IN
cord-252443-lclxrwcm	206	30	prophylactic	prophylactic	JJ
cord-252443-lclxrwcm	206	31	immunization	immunization	NN
cord-252443-lclxrwcm	206	32	with	with	IN
cord-252443-lclxrwcm	206	33	DNA	DNA	NNP
cord-252443-lclxrwcm	206	34	and	and	CC
cord-252443-lclxrwcm	206	35	recombinant	recombinant	JJ
cord-252443-lclxrwcm	206	36	adenoviral	adenoviral	JJ
cord-252443-lclxrwcm	206	37	vaccine	vaccine	NN
cord-252443-lclxrwcm	206	38	vectors	vector	NNS
cord-252443-lclxrwcm	206	39	expressing	express	VBG
cord-252443-lclxrwcm	207	1	Gag	Gag	NNP
cord-252443-lclxrwcm	207	2	Vaccination	vaccination	NN
cord-252443-lclxrwcm	207	3	preserves	preserve	VBZ
cord-252443-lclxrwcm	207	4	CD4	CD4	NNP
cord-252443-lclxrwcm	207	5	memory	memory	NN
cord-252443-lclxrwcm	207	6	T	T	NNP
cord-252443-lclxrwcm	207	7	cells	cell	NNS
cord-252443-lclxrwcm	207	8	during	during	IN
cord-252443-lclxrwcm	207	9	acute	acute	JJ
cord-252443-lclxrwcm	207	10	simian	simian	JJ
cord-252443-lclxrwcm	207	11	immunodeficiency	immunodeficiency	NN
cord-252443-lclxrwcm	207	12	virus	virus	NN
cord-252443-lclxrwcm	207	13	challenge	challenge	NN
cord-252443-lclxrwcm	207	14	Immune	immune	JJ
cord-252443-lclxrwcm	207	15	responses	response	NNS
cord-252443-lclxrwcm	207	16	against	against	IN
cord-252443-lclxrwcm	207	17	a	a	DT
cord-252443-lclxrwcm	207	18	liver	liver	NN
cord-252443-lclxrwcm	207	19	-	-	HYPH
cord-252443-lclxrwcm	207	20	stage	stage	NN
cord-252443-lclxrwcm	207	21	malaria	malaria	NN
cord-252443-lclxrwcm	207	22	antigen	antigen	NN
cord-252443-lclxrwcm	207	23	induced	induce	VBN
cord-252443-lclxrwcm	207	24	by	by	IN
cord-252443-lclxrwcm	207	25	simian	simian	JJ
cord-252443-lclxrwcm	207	26	adenoviral	adenoviral	JJ
cord-252443-lclxrwcm	207	27	vector	vector	NN
cord-252443-lclxrwcm	207	28	AdCh63	AdCh63	NNPS
cord-252443-lclxrwcm	207	29	and	and	CC
cord-252443-lclxrwcm	207	30	MVA	MVA	NNP
cord-252443-lclxrwcm	207	31	prime	prime	JJ
cord-252443-lclxrwcm	207	32	-	-	HYPH
cord-252443-lclxrwcm	207	33	boost	boost	NN
cord-252443-lclxrwcm	207	34	immunization	immunization	NN
cord-252443-lclxrwcm	207	35	in	in	IN
cord-252443-lclxrwcm	207	36	non	non	JJ
cord-252443-lclxrwcm	207	37	-	-	JJ
cord-252443-lclxrwcm	207	38	human	human	JJ
cord-252443-lclxrwcm	207	39	primates	primate	NNS
cord-252443-lclxrwcm	207	40	Prime	prime	JJ
cord-252443-lclxrwcm	207	41	-	-	HYPH
cord-252443-lclxrwcm	207	42	boost	boost	NN
cord-252443-lclxrwcm	207	43	immunization	immunization	NN
cord-252443-lclxrwcm	207	44	with	with	IN
cord-252443-lclxrwcm	207	45	adenoviral	adenoviral	NNP
cord-252443-lclxrwcm	207	46	and	and	CC
cord-252443-lclxrwcm	207	47	modified	modify	VBN
cord-252443-lclxrwcm	207	48	vaccinia	vaccinia	NN
cord-252443-lclxrwcm	207	49	virus	virus	NN
cord-252443-lclxrwcm	207	50	Ankara	Ankara	NNP
cord-252443-lclxrwcm	207	51	vectors	vector	NNS
cord-252443-lclxrwcm	207	52	enhances	enhance	VBZ
cord-252443-lclxrwcm	207	53	the	the	DT
cord-252443-lclxrwcm	207	54	durability	durability	NN
cord-252443-lclxrwcm	207	55	and	and	CC
cord-252443-lclxrwcm	207	56	polyfunctionality	polyfunctionality	NN
cord-252443-lclxrwcm	207	57	of	of	IN
cord-252443-lclxrwcm	207	58	protective	protective	JJ
cord-252443-lclxrwcm	207	59	malaria	malaria	NN
cord-252443-lclxrwcm	207	60	CD8(+	cd8(+	CD
cord-252443-lclxrwcm	207	61	)	)	-RRB-
cord-252443-lclxrwcm	208	1	T	t	NN
cord-252443-lclxrwcm	208	2	-	-	HYPH
cord-252443-lclxrwcm	208	3	cell	cell	NN
cord-252443-lclxrwcm	208	4	responses	response	NNS
cord-252443-lclxrwcm	208	5	Tailoring	tailor	VBG
cord-252443-lclxrwcm	208	6	subunit	subunit	NN
cord-252443-lclxrwcm	208	7	vaccine	vaccine	NN
cord-252443-lclxrwcm	208	8	immunogenicity	immunogenicity	NN
cord-252443-lclxrwcm	208	9	:	:	:
cord-252443-lclxrwcm	208	10	maximizing	maximize	VBG
cord-252443-lclxrwcm	208	11	antibody	antibody	NN
cord-252443-lclxrwcm	208	12	and	and	CC
cord-252443-lclxrwcm	208	13	T	T	NNP
cord-252443-lclxrwcm	208	14	cell	cell	NN
cord-252443-lclxrwcm	208	15	responses	response	NNS
cord-252443-lclxrwcm	208	16	by	by	IN
cord-252443-lclxrwcm	208	17	using	use	VBG
cord-252443-lclxrwcm	208	18	combinations	combination	NNS
cord-252443-lclxrwcm	208	19	of	of	IN
cord-252443-lclxrwcm	208	20	adenovirus	adenovirus	NN
cord-252443-lclxrwcm	208	21	,	,	,
cord-252443-lclxrwcm	208	22	poxvirus	poxvirus	NNP
cord-252443-lclxrwcm	208	23	and	and	CC
cord-252443-lclxrwcm	208	24	protein	protein	NN
cord-252443-lclxrwcm	208	25	-	-	HYPH
cord-252443-lclxrwcm	208	26	adjuvant	adjuvant	JJ
cord-252443-lclxrwcm	208	27	vaccines	vaccine	NNS
cord-252443-lclxrwcm	208	28	against	against	IN
cord-252443-lclxrwcm	208	29	Plasmodium	Plasmodium	NNP
cord-252443-lclxrwcm	208	30	falciparum	falciparum	NN
cord-252443-lclxrwcm	208	31	MSP1	MSP1	NNP