id sid tid token lemma pos cord-258021-xhx74vr6 1 1 key key NNP cord-258021-xhx74vr6 1 2 : : : cord-258021-xhx74vr6 1 3 cord-258021-xhx74vr6 cord-258021-xhx74vr6 NN cord-258021-xhx74vr6 1 4 authors author NNS cord-258021-xhx74vr6 1 5 : : : cord-258021-xhx74vr6 1 6 Waterer Waterer NNP cord-258021-xhx74vr6 1 7 , , , cord-258021-xhx74vr6 1 8 Grant Grant NNP cord-258021-xhx74vr6 1 9 W. W. NNP cord-258021-xhx74vr6 1 10 title title NN cord-258021-xhx74vr6 1 11 : : : cord-258021-xhx74vr6 1 12 Diagnosing diagnose VBG cord-258021-xhx74vr6 1 13 Viral viral JJ cord-258021-xhx74vr6 1 14 and and CC cord-258021-xhx74vr6 1 15 Atypical atypical JJ cord-258021-xhx74vr6 1 16 Pathogens Pathogens NNPS cord-258021-xhx74vr6 1 17 in in IN cord-258021-xhx74vr6 1 18 the the DT cord-258021-xhx74vr6 1 19 Setting setting NN cord-258021-xhx74vr6 1 20 of of IN cord-258021-xhx74vr6 1 21 Community Community NNP cord-258021-xhx74vr6 1 22 - - HYPH cord-258021-xhx74vr6 1 23 Acquired Acquired NNP cord-258021-xhx74vr6 1 24 Pneumonia Pneumonia NNP cord-258021-xhx74vr6 1 25 date date NN cord-258021-xhx74vr6 1 26 : : : cord-258021-xhx74vr6 1 27 2016 2016 CD cord-258021-xhx74vr6 1 28 - - HYPH cord-258021-xhx74vr6 1 29 12 12 CD cord-258021-xhx74vr6 1 30 - - SYM cord-258021-xhx74vr6 1 31 21 21 CD cord-258021-xhx74vr6 1 32 journal journal NN cord-258021-xhx74vr6 1 33 : : : cord-258021-xhx74vr6 1 34 Clin Clin NNP cord-258021-xhx74vr6 1 35 Chest Chest NNP cord-258021-xhx74vr6 1 36 Med Med NNP cord-258021-xhx74vr6 1 37 DOI doi NN cord-258021-xhx74vr6 1 38 : : : cord-258021-xhx74vr6 1 39 10.1016/ 10.1016/ CD cord-258021-xhx74vr6 2 1 j.ccm.2016.11.004 j.ccm.2016.11.004 NNP cord-258021-xhx74vr6 2 2 sha sha NNP cord-258021-xhx74vr6 2 3 : : : cord-258021-xhx74vr6 3 1 5164c1dc1e4e7ac1a053c9998f36d74a4781c153 5164c1dc1e4e7ac1a053c9998f36d74a4781c153 CD cord-258021-xhx74vr6 3 2 doc_id doc_id CD cord-258021-xhx74vr6 3 3 : : : cord-258021-xhx74vr6 4 1 258021 258021 CD cord-258021-xhx74vr6 4 2 cord_uid cord_uid NNS cord-258021-xhx74vr6 4 3 : : : cord-258021-xhx74vr6 4 4 xhx74vr6 xhx74vr6 . cord-258021-xhx74vr6 5 1 The the DT cord-258021-xhx74vr6 5 2 ‘ ' `` cord-258021-xhx74vr6 5 3 atypical atypical JJ cord-258021-xhx74vr6 5 4 ’ ' '' cord-258021-xhx74vr6 5 5 pathogens pathogen NNS cord-258021-xhx74vr6 5 6 causing cause VBG cord-258021-xhx74vr6 5 7 pneumonia pneumonia NN cord-258021-xhx74vr6 5 8 have have VBP cord-258021-xhx74vr6 5 9 long long RB cord-258021-xhx74vr6 5 10 been be VBN cord-258021-xhx74vr6 5 11 problematic problematic JJ cord-258021-xhx74vr6 5 12 for for IN cord-258021-xhx74vr6 5 13 physicians physician NNS cord-258021-xhx74vr6 5 14 because because IN cord-258021-xhx74vr6 5 15 we -PRON- PRP cord-258021-xhx74vr6 5 16 have have VBP cord-258021-xhx74vr6 5 17 had have VBN cord-258021-xhx74vr6 5 18 to to TO cord-258021-xhx74vr6 5 19 rely rely VB cord-258021-xhx74vr6 5 20 on on IN cord-258021-xhx74vr6 5 21 serologic serologic JJ cord-258021-xhx74vr6 5 22 tests test NNS cord-258021-xhx74vr6 5 23 to to TO cord-258021-xhx74vr6 5 24 make make VB cord-258021-xhx74vr6 5 25 a a DT cord-258021-xhx74vr6 5 26 diagnosis diagnosis NN cord-258021-xhx74vr6 5 27 . . . cord-258021-xhx74vr6 6 1 The the DT cord-258021-xhx74vr6 6 2 introduction introduction NN cord-258021-xhx74vr6 6 3 of of IN cord-258021-xhx74vr6 6 4 polymerase polymerase NN cord-258021-xhx74vr6 6 5 chain chain NN cord-258021-xhx74vr6 6 6 reaction reaction NN cord-258021-xhx74vr6 6 7 techniques technique NNS cord-258021-xhx74vr6 6 8 revolutionized revolutionize VBD cord-258021-xhx74vr6 6 9 the the DT cord-258021-xhx74vr6 6 10 diagnosis diagnosis NN cord-258021-xhx74vr6 6 11 of of IN cord-258021-xhx74vr6 6 12 respiratory respiratory JJ cord-258021-xhx74vr6 6 13 infections infection NNS cord-258021-xhx74vr6 6 14 and and CC cord-258021-xhx74vr6 6 15 now now RB cord-258021-xhx74vr6 6 16 a a DT cord-258021-xhx74vr6 6 17 new new JJ cord-258021-xhx74vr6 6 18 wave wave NN cord-258021-xhx74vr6 6 19 of of IN cord-258021-xhx74vr6 6 20 technologies technology NNS cord-258021-xhx74vr6 6 21 promising promise VBG cord-258021-xhx74vr6 6 22 faster fast RBR cord-258021-xhx74vr6 6 23 , , , cord-258021-xhx74vr6 6 24 cheaper cheap JJR cord-258021-xhx74vr6 6 25 , , , cord-258021-xhx74vr6 6 26 and and CC cord-258021-xhx74vr6 6 27 more more RBR cord-258021-xhx74vr6 6 28 comprehensive comprehensive JJ cord-258021-xhx74vr6 7 1 testing testing NN cord-258021-xhx74vr6 7 2 are be VBP cord-258021-xhx74vr6 7 3 becoming become VBG cord-258021-xhx74vr6 7 4 available available JJ cord-258021-xhx74vr6 7 5 . . . cord-258021-xhx74vr6 8 1 This this DT cord-258021-xhx74vr6 8 2 review review NN cord-258021-xhx74vr6 8 3 focuses focus VBZ cord-258021-xhx74vr6 8 4 principally principally RB cord-258021-xhx74vr6 8 5 on on IN cord-258021-xhx74vr6 8 6 the the DT cord-258021-xhx74vr6 8 7 diagnosis diagnosis NN cord-258021-xhx74vr6 8 8 of of IN cord-258021-xhx74vr6 8 9 Legionella Legionella NNP cord-258021-xhx74vr6 8 10 , , , cord-258021-xhx74vr6 8 11 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 8 12 , , , cord-258021-xhx74vr6 8 13 and and CC cord-258021-xhx74vr6 8 14 influenza influenza NN cord-258021-xhx74vr6 8 15 infections infection NNS cord-258021-xhx74vr6 8 16 , , , cord-258021-xhx74vr6 8 17 but but CC cord-258021-xhx74vr6 8 18 also also RB cord-258021-xhx74vr6 8 19 covers cover VBZ cord-258021-xhx74vr6 8 20 recent recent JJ cord-258021-xhx74vr6 8 21 publications publication NNS cord-258021-xhx74vr6 8 22 on on IN cord-258021-xhx74vr6 8 23 the the DT cord-258021-xhx74vr6 8 24 cutting cutting JJ cord-258021-xhx74vr6 8 25 edge edge NN cord-258021-xhx74vr6 8 26 of of IN cord-258021-xhx74vr6 8 27 diagnostic diagnostic JJ cord-258021-xhx74vr6 8 28 tools tool NNS cord-258021-xhx74vr6 8 29 likely likely JJ cord-258021-xhx74vr6 8 30 to to TO cord-258021-xhx74vr6 8 31 transform transform VB cord-258021-xhx74vr6 8 32 the the DT cord-258021-xhx74vr6 8 33 field field NN cord-258021-xhx74vr6 8 34 of of IN cord-258021-xhx74vr6 8 35 infectious infectious JJ cord-258021-xhx74vr6 8 36 diseases disease NNS cord-258021-xhx74vr6 8 37 over over IN cord-258021-xhx74vr6 8 38 the the DT cord-258021-xhx74vr6 8 39 coming come VBG cord-258021-xhx74vr6 8 40 decade decade NN cord-258021-xhx74vr6 8 41 . . . cord-258021-xhx74vr6 9 1 Despite despite IN cord-258021-xhx74vr6 9 2 many many JJ cord-258021-xhx74vr6 9 3 promises promise NNS cord-258021-xhx74vr6 9 4 that that IN cord-258021-xhx74vr6 9 5 molecular molecular JJ cord-258021-xhx74vr6 9 6 diagnostics diagnostic NNS cord-258021-xhx74vr6 9 7 would would MD cord-258021-xhx74vr6 9 8 transform transform VB cord-258021-xhx74vr6 9 9 the the DT cord-258021-xhx74vr6 9 10 management management NN cord-258021-xhx74vr6 9 11 of of IN cord-258021-xhx74vr6 9 12 infection infection NN cord-258021-xhx74vr6 9 13 , , , cord-258021-xhx74vr6 9 14 empiric empiric JJ cord-258021-xhx74vr6 9 15 therapy therapy NN cord-258021-xhx74vr6 9 16 remains remain VBZ cord-258021-xhx74vr6 9 17 the the DT cord-258021-xhx74vr6 9 18 standard standard NN cord-258021-xhx74vr6 9 19 of of IN cord-258021-xhx74vr6 9 20 care care NN cord-258021-xhx74vr6 9 21 in in IN cord-258021-xhx74vr6 9 22 community community NN cord-258021-xhx74vr6 9 23 - - HYPH cord-258021-xhx74vr6 9 24 acquired acquire VBN cord-258021-xhx74vr6 9 25 pneumonia pneumonia NN cord-258021-xhx74vr6 9 26 ( ( -LRB- cord-258021-xhx74vr6 9 27 CAP CAP NNP cord-258021-xhx74vr6 9 28 ) ) -RRB- cord-258021-xhx74vr6 9 29 . . . cord-258021-xhx74vr6 10 1 Outside outside IN cord-258021-xhx74vr6 10 2 of of IN cord-258021-xhx74vr6 10 3 etiologic etiologic NNP cord-258021-xhx74vr6 10 4 studies study NNS cord-258021-xhx74vr6 10 5 , , , cord-258021-xhx74vr6 10 6 the the DT cord-258021-xhx74vr6 10 7 vast vast JJ cord-258021-xhx74vr6 10 8 majority majority NN cord-258021-xhx74vr6 10 9 of of IN cord-258021-xhx74vr6 10 10 patients patient NNS cord-258021-xhx74vr6 10 11 never never RB cord-258021-xhx74vr6 10 12 have have VBP cord-258021-xhx74vr6 10 13 a a DT cord-258021-xhx74vr6 10 14 pathogen pathogen NN cord-258021-xhx74vr6 10 15 diagnosed diagnose VBN cord-258021-xhx74vr6 10 16 as as IN cord-258021-xhx74vr6 10 17 the the DT cord-258021-xhx74vr6 10 18 cause cause NN cord-258021-xhx74vr6 10 19 of of IN cord-258021-xhx74vr6 10 20 their -PRON- PRP$ cord-258021-xhx74vr6 10 21 pneumonia pneumonia NN cord-258021-xhx74vr6 10 22 . . . cord-258021-xhx74vr6 11 1 Although although IN cord-258021-xhx74vr6 11 2 physicians physician NNS cord-258021-xhx74vr6 11 3 are be VBP cord-258021-xhx74vr6 11 4 generally generally RB cord-258021-xhx74vr6 11 5 quite quite RB cord-258021-xhx74vr6 11 6 comfortable comfortable JJ cord-258021-xhx74vr6 11 7 with with IN cord-258021-xhx74vr6 11 8 empiric empiric JJ cord-258021-xhx74vr6 11 9 therapy therapy NN cord-258021-xhx74vr6 11 10 , , , cord-258021-xhx74vr6 11 11 the the DT cord-258021-xhx74vr6 11 12 need need NN cord-258021-xhx74vr6 11 13 to to TO cord-258021-xhx74vr6 11 14 guess guess VB cord-258021-xhx74vr6 11 15 and and CC cord-258021-xhx74vr6 11 16 fear fear NN cord-258021-xhx74vr6 11 17 of of IN cord-258021-xhx74vr6 11 18 missing miss VBG cord-258021-xhx74vr6 11 19 an an DT cord-258021-xhx74vr6 11 20 important important JJ cord-258021-xhx74vr6 11 21 pathogen pathogen NN cord-258021-xhx74vr6 11 22 inevitably inevitably RB cord-258021-xhx74vr6 11 23 leads lead VBZ cord-258021-xhx74vr6 11 24 to to IN cord-258021-xhx74vr6 11 25 a a DT cord-258021-xhx74vr6 11 26 broader broad JJR cord-258021-xhx74vr6 11 27 than than IN cord-258021-xhx74vr6 11 28 necessary necessary JJ cord-258021-xhx74vr6 11 29 spectrum spectrum NN cord-258021-xhx74vr6 11 30 of of IN cord-258021-xhx74vr6 11 31 coverage coverage NN cord-258021-xhx74vr6 11 32 , , , cord-258021-xhx74vr6 11 33 particularly particularly RB cord-258021-xhx74vr6 11 34 in in IN cord-258021-xhx74vr6 11 35 the the DT cord-258021-xhx74vr6 11 36 setting setting NN cord-258021-xhx74vr6 11 37 of of IN cord-258021-xhx74vr6 11 38 more more RBR cord-258021-xhx74vr6 11 39 severe severe JJ cord-258021-xhx74vr6 11 40 illness illness NN cord-258021-xhx74vr6 11 41 . . . cord-258021-xhx74vr6 12 1 That that IN cord-258021-xhx74vr6 12 2 viruses virus NNS cord-258021-xhx74vr6 12 3 are be VBP cord-258021-xhx74vr6 12 4 an an DT cord-258021-xhx74vr6 12 5 important important JJ cord-258021-xhx74vr6 12 6 cause cause NN cord-258021-xhx74vr6 12 7 of of IN cord-258021-xhx74vr6 12 8 pneumonia pneumonia NN cord-258021-xhx74vr6 12 9 has have VBZ cord-258021-xhx74vr6 12 10 been be VBN cord-258021-xhx74vr6 12 11 known know VBN cord-258021-xhx74vr6 12 12 since since IN cord-258021-xhx74vr6 12 13 the the DT cord-258021-xhx74vr6 12 14 identification identification NN cord-258021-xhx74vr6 12 15 of of IN cord-258021-xhx74vr6 12 16 influenza influenza NN cord-258021-xhx74vr6 12 17 in in IN cord-258021-xhx74vr6 12 18 the the DT cord-258021-xhx74vr6 12 19 early early JJ cord-258021-xhx74vr6 12 20 1930s 1930 NNS cord-258021-xhx74vr6 12 21 . . . cord-258021-xhx74vr6 13 1 1 1 LS cord-258021-xhx74vr6 14 1 Despite despite IN cord-258021-xhx74vr6 14 2 an an DT cord-258021-xhx74vr6 14 3 awareness awareness NN cord-258021-xhx74vr6 14 4 that that WDT cord-258021-xhx74vr6 14 5 viruses virus NNS cord-258021-xhx74vr6 14 6 can can MD cord-258021-xhx74vr6 14 7 cause cause VB cord-258021-xhx74vr6 14 8 CAP CAP NNP cord-258021-xhx74vr6 14 9 , , , cord-258021-xhx74vr6 14 10 it -PRON- PRP cord-258021-xhx74vr6 14 11 is be VBZ cord-258021-xhx74vr6 14 12 only only RB cord-258021-xhx74vr6 14 13 recently recently RB cord-258021-xhx74vr6 14 14 that that IN cord-258021-xhx74vr6 14 15 they -PRON- PRP cord-258021-xhx74vr6 14 16 have have VBP cord-258021-xhx74vr6 14 17 appeared appear VBN cord-258021-xhx74vr6 14 18 as as IN cord-258021-xhx74vr6 14 19 more more JJR cord-258021-xhx74vr6 14 20 than than IN cord-258021-xhx74vr6 14 21 a a DT cord-258021-xhx74vr6 14 22 footnote footnote NN cord-258021-xhx74vr6 14 23 on on IN cord-258021-xhx74vr6 14 24 the the DT cord-258021-xhx74vr6 14 25 list list NN cord-258021-xhx74vr6 14 26 of of IN cord-258021-xhx74vr6 14 27 common common JJ cord-258021-xhx74vr6 14 28 pathogens pathogen NNS cord-258021-xhx74vr6 14 29 . . . cord-258021-xhx74vr6 15 1 However however RB cord-258021-xhx74vr6 15 2 , , , cord-258021-xhx74vr6 15 3 with with IN cord-258021-xhx74vr6 15 4 modern modern JJ cord-258021-xhx74vr6 15 5 generations generation NNS cord-258021-xhx74vr6 15 6 of of IN cord-258021-xhx74vr6 15 7 diagnostic diagnostic JJ cord-258021-xhx74vr6 15 8 panels panel NNS cord-258021-xhx74vr6 15 9 , , , cord-258021-xhx74vr6 15 10 and and CC cord-258021-xhx74vr6 15 11 particularly particularly RB cord-258021-xhx74vr6 15 12 nucleic nucleic JJ cord-258021-xhx74vr6 15 13 acid acid NN cord-258021-xhx74vr6 15 14 amplification amplification NN cord-258021-xhx74vr6 15 15 tests test NNS cord-258021-xhx74vr6 15 16 , , , cord-258021-xhx74vr6 15 17 viral viral JJ cord-258021-xhx74vr6 15 18 pathogens pathogen NNS cord-258021-xhx74vr6 15 19 are be VBP cord-258021-xhx74vr6 15 20 being be VBG cord-258021-xhx74vr6 15 21 identified identify VBN cord-258021-xhx74vr6 15 22 increasingly increasingly RB cord-258021-xhx74vr6 15 23 as as IN cord-258021-xhx74vr6 15 24 not not RB cord-258021-xhx74vr6 15 25 only only RB cord-258021-xhx74vr6 15 26 common common JJ cord-258021-xhx74vr6 15 27 causes cause NNS cord-258021-xhx74vr6 15 28 of of IN cord-258021-xhx74vr6 15 29 CAP cap NN cord-258021-xhx74vr6 15 30 , , , cord-258021-xhx74vr6 15 31 but but CC cord-258021-xhx74vr6 15 32 possibly possibly RB cord-258021-xhx74vr6 15 33 as as IN cord-258021-xhx74vr6 15 34 being be VBG cord-258021-xhx74vr6 15 35 overall overall RB cord-258021-xhx74vr6 15 36 more more RBR cord-258021-xhx74vr6 15 37 common common JJ cord-258021-xhx74vr6 15 38 that that IN cord-258021-xhx74vr6 15 39 bacteria bacteria NNS cord-258021-xhx74vr6 15 40 . . . cord-258021-xhx74vr6 16 1 2 2 LS cord-258021-xhx74vr6 16 2 , , , cord-258021-xhx74vr6 16 3 3 3 CD cord-258021-xhx74vr6 16 4 With with IN cord-258021-xhx74vr6 16 5 more more RBR cord-258021-xhx74vr6 16 6 sensitive sensitive JJ cord-258021-xhx74vr6 16 7 tests test NNS cord-258021-xhx74vr6 16 8 has have VBZ cord-258021-xhx74vr6 16 9 also also RB cord-258021-xhx74vr6 16 10 come come VBN cord-258021-xhx74vr6 16 11 confirmation confirmation NN cord-258021-xhx74vr6 16 12 that that IN cord-258021-xhx74vr6 16 13 patients patient NNS cord-258021-xhx74vr6 16 14 with with IN cord-258021-xhx74vr6 16 15 CAP CAP NNP cord-258021-xhx74vr6 16 16 frequently frequently RB cord-258021-xhx74vr6 16 17 have have VBP cord-258021-xhx74vr6 16 18 multiple multiple JJ cord-258021-xhx74vr6 16 19 pathogens pathogen NNS cord-258021-xhx74vr6 16 20 present present JJ cord-258021-xhx74vr6 16 21 , , , cord-258021-xhx74vr6 16 22 particularly particularly RB cord-258021-xhx74vr6 16 23 the the DT cord-258021-xhx74vr6 16 24 combination combination NN cord-258021-xhx74vr6 16 25 of of IN cord-258021-xhx74vr6 16 26 bacterial bacterial JJ cord-258021-xhx74vr6 16 27 and and CC cord-258021-xhx74vr6 16 28 viral viral JJ cord-258021-xhx74vr6 16 29 infection infection NN cord-258021-xhx74vr6 16 30 . . . cord-258021-xhx74vr6 17 1 The the DT cord-258021-xhx74vr6 17 2 term term NN cord-258021-xhx74vr6 17 3 " " `` cord-258021-xhx74vr6 17 4 atypical atypical JJ cord-258021-xhx74vr6 17 5 pneumonia pneumonia NN cord-258021-xhx74vr6 17 6 " " '' cord-258021-xhx74vr6 17 7 was be VBD cord-258021-xhx74vr6 17 8 coined coin VBN cord-258021-xhx74vr6 17 9 in in IN cord-258021-xhx74vr6 17 10 first first JJ cord-258021-xhx74vr6 17 11 half half NN cord-258021-xhx74vr6 17 12 of of IN cord-258021-xhx74vr6 17 13 the the DT cord-258021-xhx74vr6 17 14 20th 20th JJ cord-258021-xhx74vr6 17 15 century century NN cord-258021-xhx74vr6 17 16 and and CC cord-258021-xhx74vr6 17 17 used use VBD cord-258021-xhx74vr6 17 18 to to TO cord-258021-xhx74vr6 17 19 describe describe VB cord-258021-xhx74vr6 17 20 pneumonia pneumonia NN cord-258021-xhx74vr6 17 21 owing owe VBG cord-258021-xhx74vr6 17 22 to to IN cord-258021-xhx74vr6 17 23 pathogens pathogen NNS cord-258021-xhx74vr6 17 24 that that WDT cord-258021-xhx74vr6 17 25 were be VBD cord-258021-xhx74vr6 17 26 not not RB cord-258021-xhx74vr6 17 27 detectable detectable JJ cord-258021-xhx74vr6 17 28 by by IN cord-258021-xhx74vr6 17 29 standard standard JJ cord-258021-xhx74vr6 17 30 Gram gram NN cord-258021-xhx74vr6 17 31 staining staining NN cord-258021-xhx74vr6 17 32 or or CC cord-258021-xhx74vr6 17 33 traditional traditional JJ cord-258021-xhx74vr6 17 34 culture culture NN cord-258021-xhx74vr6 17 35 methods method NNS cord-258021-xhx74vr6 17 36 and and CC cord-258021-xhx74vr6 17 37 typically typically RB cord-258021-xhx74vr6 17 38 associated associate VBN cord-258021-xhx74vr6 17 39 with with IN cord-258021-xhx74vr6 17 40 headache headache NN cord-258021-xhx74vr6 17 41 , , , cord-258021-xhx74vr6 17 42 low low JJ cord-258021-xhx74vr6 17 43 - - HYPH cord-258021-xhx74vr6 17 44 grade grade NN cord-258021-xhx74vr6 17 45 fever fever NN cord-258021-xhx74vr6 17 46 , , , cord-258021-xhx74vr6 17 47 cough cough NN cord-258021-xhx74vr6 17 48 , , , cord-258021-xhx74vr6 17 49 and and CC cord-258021-xhx74vr6 17 50 malaise malaise NN cord-258021-xhx74vr6 17 51 . . . cord-258021-xhx74vr6 18 1 The the DT cord-258021-xhx74vr6 18 2 predominant predominant JJ cord-258021-xhx74vr6 18 3 pathogens pathogen NNS cord-258021-xhx74vr6 18 4 that that WDT cord-258021-xhx74vr6 18 5 have have VBP cord-258021-xhx74vr6 18 6 become become VBN cord-258021-xhx74vr6 18 7 associated associate VBN cord-258021-xhx74vr6 18 8 with with IN cord-258021-xhx74vr6 18 9 atypical atypical JJ cord-258021-xhx74vr6 18 10 pneumonia pneumonia NN cord-258021-xhx74vr6 18 11 are be VBP cord-258021-xhx74vr6 18 12 Mycoplasma mycoplasma NN cord-258021-xhx74vr6 18 13 pneumoniae pneumoniae NN cord-258021-xhx74vr6 18 14 ( ( -LRB- cord-258021-xhx74vr6 18 15 first first RB cord-258021-xhx74vr6 18 16 identified identify VBN cord-258021-xhx74vr6 18 17 in in IN cord-258021-xhx74vr6 18 18 human human JJ cord-258021-xhx74vr6 18 19 lung lung NN cord-258021-xhx74vr6 18 20 in in IN cord-258021-xhx74vr6 18 21 1944 1944 CD cord-258021-xhx74vr6 18 22 ) ) -RRB- cord-258021-xhx74vr6 18 23 , , , cord-258021-xhx74vr6 18 24 4 4 CD cord-258021-xhx74vr6 18 25 Legionella Legionella NNP cord-258021-xhx74vr6 18 26 pneumophila pneumophila NN cord-258021-xhx74vr6 18 27 ( ( -LRB- cord-258021-xhx74vr6 18 28 first first RB cord-258021-xhx74vr6 18 29 identified identify VBN cord-258021-xhx74vr6 18 30 as as IN cord-258021-xhx74vr6 18 31 a a DT cord-258021-xhx74vr6 18 32 significant significant JJ cord-258021-xhx74vr6 18 33 pneumonia pneumonia NN cord-258021-xhx74vr6 18 34 pathogen pathogen NN cord-258021-xhx74vr6 18 35 in in IN cord-258021-xhx74vr6 18 36 1977 1977 CD cord-258021-xhx74vr6 18 37 after after IN cord-258021-xhx74vr6 18 38 the the DT cord-258021-xhx74vr6 18 39 outbreak outbreak NN cord-258021-xhx74vr6 18 40 at at IN cord-258021-xhx74vr6 18 41 a a DT cord-258021-xhx74vr6 18 42 convention convention NN cord-258021-xhx74vr6 18 43 in in IN cord-258021-xhx74vr6 18 44 Philadelphia Philadelphia NNP cord-258021-xhx74vr6 18 45 in in IN cord-258021-xhx74vr6 18 46 1976 1976 CD cord-258021-xhx74vr6 18 47 ) ) -RRB- cord-258021-xhx74vr6 18 48 5 5 CD cord-258021-xhx74vr6 18 49 and and CC cord-258021-xhx74vr6 18 50 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 18 51 pneumoniae pneumoniae NN cord-258021-xhx74vr6 18 52 ( ( -LRB- cord-258021-xhx74vr6 18 53 first first RB cord-258021-xhx74vr6 18 54 identified identify VBN cord-258021-xhx74vr6 18 55 in in IN cord-258021-xhx74vr6 18 56 the the DT cord-258021-xhx74vr6 18 57 respiratory respiratory JJ cord-258021-xhx74vr6 18 58 tract tract NN cord-258021-xhx74vr6 18 59 in in IN cord-258021-xhx74vr6 18 60 1984 1984 CD cord-258021-xhx74vr6 18 61 ) ) -RRB- cord-258021-xhx74vr6 18 62 . . . cord-258021-xhx74vr6 19 1 6 6 CD cord-258021-xhx74vr6 20 1 A a DT cord-258021-xhx74vr6 20 2 variety variety NN cord-258021-xhx74vr6 20 3 of of IN cord-258021-xhx74vr6 20 4 different different JJ cord-258021-xhx74vr6 20 5 species specie NNS cord-258021-xhx74vr6 20 6 of of IN cord-258021-xhx74vr6 20 7 these these DT cord-258021-xhx74vr6 20 8 genera genus NNS cord-258021-xhx74vr6 20 9 are be VBP cord-258021-xhx74vr6 20 10 now now RB cord-258021-xhx74vr6 20 11 recognized recognize VBN cord-258021-xhx74vr6 20 12 as as IN cord-258021-xhx74vr6 20 13 pneumonia pneumonia NN cord-258021-xhx74vr6 20 14 pathogens pathogen NNS cord-258021-xhx74vr6 20 15 . . . cord-258021-xhx74vr6 21 1 This this DT cord-258021-xhx74vr6 21 2 review review NN cord-258021-xhx74vr6 21 3 covers cover VBZ cord-258021-xhx74vr6 21 4 the the DT cord-258021-xhx74vr6 21 5 main main JJ cord-258021-xhx74vr6 21 6 approaches approach NNS cord-258021-xhx74vr6 21 7 to to IN cord-258021-xhx74vr6 21 8 the the DT cord-258021-xhx74vr6 21 9 diagnosis diagnosis NN cord-258021-xhx74vr6 21 10 of of IN cord-258021-xhx74vr6 21 11 atypical atypical JJ cord-258021-xhx74vr6 21 12 and and CC cord-258021-xhx74vr6 21 13 viral viral JJ cord-258021-xhx74vr6 21 14 infections infection NNS cord-258021-xhx74vr6 21 15 in in IN cord-258021-xhx74vr6 21 16 the the DT cord-258021-xhx74vr6 21 17 setting setting NN cord-258021-xhx74vr6 21 18 of of IN cord-258021-xhx74vr6 21 19 pneumonia pneumonia NN cord-258021-xhx74vr6 21 20 . . . cord-258021-xhx74vr6 22 1 The the DT cord-258021-xhx74vr6 22 2 most most RBS cord-258021-xhx74vr6 22 3 common common JJ cord-258021-xhx74vr6 22 4 approach approach NN cord-258021-xhx74vr6 22 5 has have VBZ cord-258021-xhx74vr6 22 6 been be VBN cord-258021-xhx74vr6 22 7 the the DT cord-258021-xhx74vr6 22 8 use use NN cord-258021-xhx74vr6 22 9 of of IN cord-258021-xhx74vr6 22 10 pathogen pathogen NN cord-258021-xhx74vr6 22 11 - - HYPH cord-258021-xhx74vr6 22 12 specific specific JJ cord-258021-xhx74vr6 22 13 assays assay NNS cord-258021-xhx74vr6 22 14 for for IN cord-258021-xhx74vr6 22 15 use use NN cord-258021-xhx74vr6 22 16 in in IN cord-258021-xhx74vr6 22 17 urine urine NN cord-258021-xhx74vr6 22 18 , , , cord-258021-xhx74vr6 22 19 blood blood NN cord-258021-xhx74vr6 22 20 , , , cord-258021-xhx74vr6 22 21 or or CC cord-258021-xhx74vr6 22 22 sputum sputum NN cord-258021-xhx74vr6 22 23 . . . cord-258021-xhx74vr6 23 1 Although although IN cord-258021-xhx74vr6 23 2 serologic serologic NNP cord-258021-xhx74vr6 23 3 tests test NNS cord-258021-xhx74vr6 23 4 based base VBN cord-258021-xhx74vr6 23 5 on on IN cord-258021-xhx74vr6 23 6 detecting detect VBG cord-258021-xhx74vr6 23 7 antibodies antibody NNS cord-258021-xhx74vr6 23 8 to to IN cord-258021-xhx74vr6 23 9 specific specific JJ cord-258021-xhx74vr6 23 10 pathogens pathogen NNS cord-258021-xhx74vr6 23 11 were be VBD cord-258021-xhx74vr6 23 12 the the DT cord-258021-xhx74vr6 23 13 predominant predominant JJ cord-258021-xhx74vr6 23 14 technique technique NN cord-258021-xhx74vr6 23 15 for for IN cord-258021-xhx74vr6 23 16 decades decade NNS cord-258021-xhx74vr6 23 17 , , , cord-258021-xhx74vr6 23 18 they -PRON- PRP cord-258021-xhx74vr6 23 19 all all DT cord-258021-xhx74vr6 23 20 have have VBP cord-258021-xhx74vr6 23 21 limitations limitation NNS cord-258021-xhx74vr6 23 22 in in IN cord-258021-xhx74vr6 23 23 early early JJ cord-258021-xhx74vr6 23 24 disease disease NN cord-258021-xhx74vr6 23 25 before before IN cord-258021-xhx74vr6 23 26 an an DT cord-258021-xhx74vr6 23 27 adaptive adaptive JJ cord-258021-xhx74vr6 23 28 immune immune JJ cord-258021-xhx74vr6 23 29 response response NN cord-258021-xhx74vr6 23 30 being be VBG cord-258021-xhx74vr6 23 31 constituted constitute VBN cord-258021-xhx74vr6 23 32 as as RB cord-258021-xhx74vr6 23 33 well well RB cord-258021-xhx74vr6 23 34 as as IN cord-258021-xhx74vr6 23 35 issues issue NNS cord-258021-xhx74vr6 23 36 of of IN cord-258021-xhx74vr6 23 37 cross cross JJ cord-258021-xhx74vr6 23 38 - - NN cord-258021-xhx74vr6 23 39 reactivity reactivity JJ cord-258021-xhx74vr6 23 40 reducing reduce VBG cord-258021-xhx74vr6 23 41 specificity specificity NN cord-258021-xhx74vr6 23 42 . . . cord-258021-xhx74vr6 24 1 Polymerase polymerase NN cord-258021-xhx74vr6 24 2 chain chain NN cord-258021-xhx74vr6 24 3 reaction reaction NN cord-258021-xhx74vr6 24 4 ( ( -LRB- cord-258021-xhx74vr6 24 5 PCR)-based pcr)-based JJ cord-258021-xhx74vr6 24 6 techniques technique NNS cord-258021-xhx74vr6 24 7 are be VBP cord-258021-xhx74vr6 24 8 now now RB cord-258021-xhx74vr6 24 9 the the DT cord-258021-xhx74vr6 24 10 primary primary JJ cord-258021-xhx74vr6 24 11 modality modality NN cord-258021-xhx74vr6 24 12 for for IN cord-258021-xhx74vr6 24 13 the the DT cord-258021-xhx74vr6 24 14 detection detection NN cord-258021-xhx74vr6 24 15 of of IN cord-258021-xhx74vr6 24 16 atypical atypical JJ cord-258021-xhx74vr6 24 17 pathogens pathogen NNS cord-258021-xhx74vr6 24 18 in in IN cord-258021-xhx74vr6 24 19 most most JJS cord-258021-xhx74vr6 24 20 settings setting NNS cord-258021-xhx74vr6 24 21 . . . cord-258021-xhx74vr6 25 1 More more RBR cord-258021-xhx74vr6 25 2 recently recently RB cord-258021-xhx74vr6 25 3 , , , cord-258021-xhx74vr6 25 4 there there EX cord-258021-xhx74vr6 25 5 has have VBZ cord-258021-xhx74vr6 25 6 been be VBN cord-258021-xhx74vr6 25 7 the the DT cord-258021-xhx74vr6 25 8 development development NN cord-258021-xhx74vr6 25 9 of of IN cord-258021-xhx74vr6 25 10 multipathogen multipathogen NNP cord-258021-xhx74vr6 25 11 detection detection NN cord-258021-xhx74vr6 25 12 platforms platform NNS cord-258021-xhx74vr6 25 13 that that WDT cord-258021-xhx74vr6 25 14 have have VBP cord-258021-xhx74vr6 25 15 become become VBN cord-258021-xhx74vr6 25 16 used use VBN cord-258021-xhx74vr6 25 17 increasingly increasingly RB cord-258021-xhx74vr6 25 18 in in IN cord-258021-xhx74vr6 25 19 the the DT cord-258021-xhx74vr6 25 20 setting setting NN cord-258021-xhx74vr6 25 21 of of IN cord-258021-xhx74vr6 25 22 pneumonia pneumonia NN cord-258021-xhx74vr6 25 23 . . . cord-258021-xhx74vr6 26 1 Before before IN cord-258021-xhx74vr6 26 2 moving move VBG cord-258021-xhx74vr6 26 3 to to IN cord-258021-xhx74vr6 26 4 laboratory laboratory NN cord-258021-xhx74vr6 26 5 tests test NNS cord-258021-xhx74vr6 26 6 , , , cord-258021-xhx74vr6 26 7 it -PRON- PRP cord-258021-xhx74vr6 26 8 is be VBZ cord-258021-xhx74vr6 26 9 worth worth JJ cord-258021-xhx74vr6 26 10 briefly briefly RB cord-258021-xhx74vr6 26 11 looking look VBG cord-258021-xhx74vr6 26 12 at at IN cord-258021-xhx74vr6 26 13 the the DT cord-258021-xhx74vr6 26 14 evidence evidence NN cord-258021-xhx74vr6 26 15 of of IN cord-258021-xhx74vr6 26 16 whether whether IN cord-258021-xhx74vr6 26 17 there there EX cord-258021-xhx74vr6 26 18 are be VBP cord-258021-xhx74vr6 26 19 any any DT cord-258021-xhx74vr6 26 20 specific specific JJ cord-258021-xhx74vr6 26 21 clinical clinical JJ cord-258021-xhx74vr6 26 22 or or CC cord-258021-xhx74vr6 26 23 radiological radiological JJ cord-258021-xhx74vr6 26 24 features feature NNS cord-258021-xhx74vr6 26 25 in in IN cord-258021-xhx74vr6 26 26 CAP cap NN cord-258021-xhx74vr6 26 27 that that WDT cord-258021-xhx74vr6 26 28 help help NN cord-258021-xhx74vr6 26 29 to to TO cord-258021-xhx74vr6 26 30 deduce deduce VB cord-258021-xhx74vr6 26 31 reliably reliably RB cord-258021-xhx74vr6 26 32 the the DT cord-258021-xhx74vr6 26 33 pathogen pathogen NN cord-258021-xhx74vr6 26 34 . . . cord-258021-xhx74vr6 27 1 There there EX cord-258021-xhx74vr6 27 2 are be VBP cord-258021-xhx74vr6 27 3 definitely definitely RB cord-258021-xhx74vr6 27 4 clinical clinical JJ cord-258021-xhx74vr6 27 5 features feature NNS cord-258021-xhx74vr6 27 6 that that WDT cord-258021-xhx74vr6 27 7 are be VBP cord-258021-xhx74vr6 27 8 seen see VBN cord-258021-xhx74vr6 27 9 more more RBR cord-258021-xhx74vr6 27 10 commonly commonly RB cord-258021-xhx74vr6 27 11 in in IN cord-258021-xhx74vr6 27 12 some some DT cord-258021-xhx74vr6 27 13 of of IN cord-258021-xhx74vr6 27 14 the the DT cord-258021-xhx74vr6 27 15 atypical atypical JJ cord-258021-xhx74vr6 27 16 pathogens pathogen NNS cord-258021-xhx74vr6 27 17 than than IN cord-258021-xhx74vr6 27 18 with with IN cord-258021-xhx74vr6 27 19 disease disease NN cord-258021-xhx74vr6 27 20 owing owe VBG cord-258021-xhx74vr6 27 21 to to IN cord-258021-xhx74vr6 27 22 Streptococcus streptococcus NN cord-258021-xhx74vr6 27 23 pneumoniae pneumoniae NN cord-258021-xhx74vr6 27 24 . . . cord-258021-xhx74vr6 28 1 Examples example NNS cord-258021-xhx74vr6 28 2 include include VBP cord-258021-xhx74vr6 28 3 erythema erythema NN cord-258021-xhx74vr6 28 4 multiforme multiforme NN cord-258021-xhx74vr6 28 5 with with IN cord-258021-xhx74vr6 28 6 M M NNP cord-258021-xhx74vr6 28 7 pneumoniae pneumoniae NN cord-258021-xhx74vr6 28 8 , , , cord-258021-xhx74vr6 28 9 diarrhea diarrhea NN cord-258021-xhx74vr6 28 10 with with IN cord-258021-xhx74vr6 28 11 L L NNP cord-258021-xhx74vr6 28 12 pneumophila pneumophila NN cord-258021-xhx74vr6 28 13 , , , cord-258021-xhx74vr6 28 14 and and CC cord-258021-xhx74vr6 28 15 rhinorrhea rhinorrhea VB cord-258021-xhx74vr6 28 16 with with IN cord-258021-xhx74vr6 28 17 influenza influenza NN cord-258021-xhx74vr6 28 18 . . . cord-258021-xhx74vr6 29 1 However however RB cord-258021-xhx74vr6 29 2 , , , cord-258021-xhx74vr6 29 3 there there EX cord-258021-xhx74vr6 29 4 is be VBZ cord-258021-xhx74vr6 29 5 ample ample JJ cord-258021-xhx74vr6 29 6 evidence evidence NN cord-258021-xhx74vr6 29 7 that that IN cord-258021-xhx74vr6 29 8 no no DT cord-258021-xhx74vr6 29 9 set set NN cord-258021-xhx74vr6 29 10 of of IN cord-258021-xhx74vr6 29 11 clinical clinical JJ cord-258021-xhx74vr6 29 12 symptoms symptom NNS cord-258021-xhx74vr6 29 13 or or CC cord-258021-xhx74vr6 29 14 signs sign NNS cord-258021-xhx74vr6 29 15 has have VBZ cord-258021-xhx74vr6 29 16 sufficient sufficient JJ cord-258021-xhx74vr6 29 17 predictive predictive JJ cord-258021-xhx74vr6 29 18 ability ability NN cord-258021-xhx74vr6 29 19 to to TO cord-258021-xhx74vr6 29 20 rule rule VB cord-258021-xhx74vr6 29 21 in in IN cord-258021-xhx74vr6 29 22 or or CC cord-258021-xhx74vr6 29 23 out out IN cord-258021-xhx74vr6 29 24 any any DT cord-258021-xhx74vr6 29 25 atypical atypical JJ cord-258021-xhx74vr6 29 26 or or CC cord-258021-xhx74vr6 29 27 viral viral JJ cord-258021-xhx74vr6 29 28 pathogens pathogen NNS cord-258021-xhx74vr6 29 29 , , , cord-258021-xhx74vr6 29 30 especially especially RB cord-258021-xhx74vr6 29 31 M M NNP cord-258021-xhx74vr6 29 32 pneumoniae pneumoniae NN cord-258021-xhx74vr6 29 33 7 7 CD cord-258021-xhx74vr6 29 34 and and CC cord-258021-xhx74vr6 29 35 Legionella Legionella NNP cord-258021-xhx74vr6 29 36 . . . cord-258021-xhx74vr6 30 1 [ [ -LRB- cord-258021-xhx74vr6 30 2 8 8 CD cord-258021-xhx74vr6 30 3 ] ] -RRB- cord-258021-xhx74vr6 30 4 [ [ -LRB- cord-258021-xhx74vr6 30 5 9 9 CD cord-258021-xhx74vr6 30 6 ] ] -RRB- cord-258021-xhx74vr6 30 7 [ [ -LRB- cord-258021-xhx74vr6 30 8 10 10 CD cord-258021-xhx74vr6 30 9 ] ] -RRB- cord-258021-xhx74vr6 31 1 A a DT cord-258021-xhx74vr6 31 2 number number NN cord-258021-xhx74vr6 31 3 of of IN cord-258021-xhx74vr6 31 4 nonmicrobiological nonmicrobiological JJ cord-258021-xhx74vr6 31 5 tests test NNS cord-258021-xhx74vr6 31 6 have have VBP cord-258021-xhx74vr6 31 7 also also RB cord-258021-xhx74vr6 31 8 been be VBN cord-258021-xhx74vr6 31 9 proposed propose VBN cord-258021-xhx74vr6 31 10 as as IN cord-258021-xhx74vr6 31 11 being be VBG cord-258021-xhx74vr6 31 12 able able JJ cord-258021-xhx74vr6 31 13 to to TO cord-258021-xhx74vr6 31 14 discriminate discriminate VB cord-258021-xhx74vr6 31 15 between between IN cord-258021-xhx74vr6 31 16 " " `` cord-258021-xhx74vr6 31 17 atypical atypical JJ cord-258021-xhx74vr6 31 18 " " '' cord-258021-xhx74vr6 31 19 and and CC cord-258021-xhx74vr6 31 20 " " `` cord-258021-xhx74vr6 31 21 typical typical JJ cord-258021-xhx74vr6 31 22 " " '' cord-258021-xhx74vr6 31 23 pathogens pathogen NNS cord-258021-xhx74vr6 31 24 , , , cord-258021-xhx74vr6 31 25 including include VBG cord-258021-xhx74vr6 31 26 the the DT cord-258021-xhx74vr6 31 27 peripheral peripheral JJ cord-258021-xhx74vr6 31 28 white white JJ cord-258021-xhx74vr6 31 29 cell cell NN cord-258021-xhx74vr6 31 30 count count NN cord-258021-xhx74vr6 31 31 and and CC cord-258021-xhx74vr6 31 32 procalcitonin procalcitonin NNS cord-258021-xhx74vr6 31 33 . . . cord-258021-xhx74vr6 32 1 Although although IN cord-258021-xhx74vr6 32 2 peripheral peripheral JJ cord-258021-xhx74vr6 32 3 white white JJ cord-258021-xhx74vr6 32 4 cell cell NN cord-258021-xhx74vr6 32 5 counts count NNS cord-258021-xhx74vr6 32 6 do do VBP cord-258021-xhx74vr6 32 7 tend tend VB cord-258021-xhx74vr6 32 8 to to TO cord-258021-xhx74vr6 32 9 be be VB cord-258021-xhx74vr6 32 10 lower low JJR cord-258021-xhx74vr6 32 11 in in IN cord-258021-xhx74vr6 32 12 viral viral JJ cord-258021-xhx74vr6 32 13 infections infection NNS cord-258021-xhx74vr6 32 14 compared compare VBN cord-258021-xhx74vr6 32 15 with with IN cord-258021-xhx74vr6 32 16 bacterial bacterial JJ cord-258021-xhx74vr6 32 17 infections infection NNS cord-258021-xhx74vr6 32 18 , , , cord-258021-xhx74vr6 32 19 this this DT cord-258021-xhx74vr6 32 20 is be VBZ cord-258021-xhx74vr6 32 21 not not RB cord-258021-xhx74vr6 32 22 particularly particularly RB cord-258021-xhx74vr6 32 23 discriminating discriminate VBG cord-258021-xhx74vr6 32 24 at at IN cord-258021-xhx74vr6 32 25 an an DT cord-258021-xhx74vr6 32 26 individual individual JJ cord-258021-xhx74vr6 32 27 patient patient JJ cord-258021-xhx74vr6 32 28 level level NN cord-258021-xhx74vr6 32 29 and and CC cord-258021-xhx74vr6 32 30 certainly certainly RB cord-258021-xhx74vr6 32 31 not not RB cord-258021-xhx74vr6 32 32 accurate accurate JJ cord-258021-xhx74vr6 32 33 enough enough RB cord-258021-xhx74vr6 32 34 to to TO cord-258021-xhx74vr6 32 35 use use VB cord-258021-xhx74vr6 32 36 to to TO cord-258021-xhx74vr6 32 37 determine determine VB cord-258021-xhx74vr6 32 38 empiric empiric JJ cord-258021-xhx74vr6 32 39 therapy therapy NN cord-258021-xhx74vr6 32 40 . . . cord-258021-xhx74vr6 33 1 11 11 CD cord-258021-xhx74vr6 34 1 Procalcitonin Procalcitonin NNP cord-258021-xhx74vr6 34 2 seems seem VBZ cord-258021-xhx74vr6 34 3 to to TO cord-258021-xhx74vr6 34 4 be be VB cord-258021-xhx74vr6 34 5 more more RBR cord-258021-xhx74vr6 34 6 accurate accurate JJ cord-258021-xhx74vr6 34 7 than than IN cord-258021-xhx74vr6 34 8 white white JJ cord-258021-xhx74vr6 34 9 cell cell NN cord-258021-xhx74vr6 34 10 count count NN cord-258021-xhx74vr6 34 11 , , , cord-258021-xhx74vr6 34 12 11 11 CD cord-258021-xhx74vr6 34 13 but but CC cord-258021-xhx74vr6 34 14 does do VBZ cord-258021-xhx74vr6 34 15 not not RB cord-258021-xhx74vr6 34 16 discriminate discriminate VB cord-258021-xhx74vr6 34 17 between between IN cord-258021-xhx74vr6 34 18 atypical atypical JJ cord-258021-xhx74vr6 34 19 bacterial bacterial JJ cord-258021-xhx74vr6 34 20 infection infection NN cord-258021-xhx74vr6 34 21 and and CC cord-258021-xhx74vr6 34 22 viral viral JJ cord-258021-xhx74vr6 34 23 infection infection NN cord-258021-xhx74vr6 34 24 12 12 CD cord-258021-xhx74vr6 34 25 and and CC cord-258021-xhx74vr6 34 26 may may MD cord-258021-xhx74vr6 34 27 be be VB cord-258021-xhx74vr6 34 28 misleading misleading JJ cord-258021-xhx74vr6 34 29 , , , cord-258021-xhx74vr6 34 30 particularly particularly RB cord-258021-xhx74vr6 34 31 in in IN cord-258021-xhx74vr6 34 32 critically critically RB cord-258021-xhx74vr6 34 33 ill ill JJ cord-258021-xhx74vr6 34 34 patients patient NNS cord-258021-xhx74vr6 34 35 or or CC cord-258021-xhx74vr6 34 36 in in IN cord-258021-xhx74vr6 34 37 patients patient NNS cord-258021-xhx74vr6 34 38 with with IN cord-258021-xhx74vr6 34 39 bacterial bacterial JJ cord-258021-xhx74vr6 34 40 and and CC cord-258021-xhx74vr6 34 41 viral viral JJ cord-258021-xhx74vr6 34 42 coinfection coinfection NN cord-258021-xhx74vr6 34 43 . . . cord-258021-xhx74vr6 35 1 13 13 CD cord-258021-xhx74vr6 36 1 A a DT cord-258021-xhx74vr6 36 2 definitive definitive JJ cord-258021-xhx74vr6 36 3 diagnosis diagnosis NN cord-258021-xhx74vr6 36 4 based base VBN cord-258021-xhx74vr6 36 5 on on IN cord-258021-xhx74vr6 36 6 detecting detect VBG cord-258021-xhx74vr6 36 7 the the DT cord-258021-xhx74vr6 36 8 infection infection NN cord-258021-xhx74vr6 36 9 pathogen(s pathogen(s NNP cord-258021-xhx74vr6 36 10 ) ) -RRB- cord-258021-xhx74vr6 36 11 , , , cord-258021-xhx74vr6 36 12 therefore therefore RB cord-258021-xhx74vr6 36 13 , , , cord-258021-xhx74vr6 36 14 remains remain VBZ cord-258021-xhx74vr6 36 15 critical critical JJ cord-258021-xhx74vr6 36 16 if if IN cord-258021-xhx74vr6 36 17 we -PRON- PRP cord-258021-xhx74vr6 36 18 are be VBP cord-258021-xhx74vr6 36 19 to to TO cord-258021-xhx74vr6 36 20 improve improve VB cord-258021-xhx74vr6 36 21 the the DT cord-258021-xhx74vr6 36 22 accuracy accuracy NN cord-258021-xhx74vr6 36 23 of of IN cord-258021-xhx74vr6 36 24 empiric empiric JJ cord-258021-xhx74vr6 36 25 therapy therapy NN cord-258021-xhx74vr6 36 26 . . . cord-258021-xhx74vr6 37 1 Very very RB cord-258021-xhx74vr6 37 2 little little JJ cord-258021-xhx74vr6 37 3 has have VBZ cord-258021-xhx74vr6 37 4 changed change VBN cord-258021-xhx74vr6 37 5 in in IN cord-258021-xhx74vr6 37 6 the the DT cord-258021-xhx74vr6 37 7 diagnosis diagnosis NN cord-258021-xhx74vr6 37 8 of of IN cord-258021-xhx74vr6 37 9 Legionella Legionella NNP cord-258021-xhx74vr6 37 10 infection infection NN cord-258021-xhx74vr6 37 11 since since IN cord-258021-xhx74vr6 37 12 we -PRON- PRP cord-258021-xhx74vr6 37 13 reviewed review VBD cord-258021-xhx74vr6 37 14 this this DT cord-258021-xhx74vr6 37 15 topic topic NN cord-258021-xhx74vr6 37 16 comprehensively comprehensively RB cord-258021-xhx74vr6 37 17 15 15 CD cord-258021-xhx74vr6 37 18 years year NNS cord-258021-xhx74vr6 37 19 ago ago RB cord-258021-xhx74vr6 37 20 . . . cord-258021-xhx74vr6 38 1 14 14 CD cord-258021-xhx74vr6 39 1 In in IN cord-258021-xhx74vr6 39 2 most most JJS cord-258021-xhx74vr6 39 3 settings setting NNS cord-258021-xhx74vr6 39 4 , , , cord-258021-xhx74vr6 39 5 Legionella Legionella NNP cord-258021-xhx74vr6 39 6 is be VBZ cord-258021-xhx74vr6 39 7 underdiagnosed underdiagnosed JJ cord-258021-xhx74vr6 39 8 and and CC cord-258021-xhx74vr6 39 9 therefore therefore RB cord-258021-xhx74vr6 39 10 underrecognized underrecognize VBN cord-258021-xhx74vr6 39 11 owing owe VBG cord-258021-xhx74vr6 39 12 to to IN cord-258021-xhx74vr6 39 13 routine routine JJ cord-258021-xhx74vr6 39 14 testing testing NN cord-258021-xhx74vr6 39 15 not not RB cord-258021-xhx74vr6 39 16 being be VBG cord-258021-xhx74vr6 39 17 performed perform VBN cord-258021-xhx74vr6 39 18 . . . cord-258021-xhx74vr6 40 1 15 15 CD cord-258021-xhx74vr6 40 2 Legionella legionella NN cord-258021-xhx74vr6 40 3 infections infection NNS cord-258021-xhx74vr6 40 4 seem seem VBP cord-258021-xhx74vr6 40 5 to to TO cord-258021-xhx74vr6 40 6 be be VB cord-258021-xhx74vr6 40 7 increasing increase VBG cord-258021-xhx74vr6 40 8 in in IN cord-258021-xhx74vr6 40 9 the the DT cord-258021-xhx74vr6 40 10 United United NNP cord-258021-xhx74vr6 40 11 States States NNP cord-258021-xhx74vr6 40 12 , , , cord-258021-xhx74vr6 40 13 16 16 CD cord-258021-xhx74vr6 40 14 , , , cord-258021-xhx74vr6 40 15 17 17 CD cord-258021-xhx74vr6 40 16 possibly possibly RB cord-258021-xhx74vr6 40 17 owing owe VBG cord-258021-xhx74vr6 40 18 to to IN cord-258021-xhx74vr6 40 19 recent recent JJ cord-258021-xhx74vr6 40 20 climate climate NN cord-258021-xhx74vr6 40 21 change change NN cord-258021-xhx74vr6 40 22 , , , cord-258021-xhx74vr6 40 23 including include VBG cord-258021-xhx74vr6 40 24 a a DT cord-258021-xhx74vr6 40 25 number number NN cord-258021-xhx74vr6 40 26 of of IN cord-258021-xhx74vr6 40 27 severe severe JJ cord-258021-xhx74vr6 40 28 outbreaks outbreak NNS cord-258021-xhx74vr6 40 29 with with IN cord-258021-xhx74vr6 40 30 multiple multiple JJ cord-258021-xhx74vr6 40 31 fatalities fatality NNS cord-258021-xhx74vr6 40 32 , , , cord-258021-xhx74vr6 40 33 18 18 CD cord-258021-xhx74vr6 40 34 which which WDT cord-258021-xhx74vr6 40 35 has have VBZ cord-258021-xhx74vr6 40 36 led lead VBN cord-258021-xhx74vr6 40 37 to to IN cord-258021-xhx74vr6 40 38 increased increase VBN cord-258021-xhx74vr6 40 39 interest interest NN cord-258021-xhx74vr6 40 40 in in IN cord-258021-xhx74vr6 40 41 its -PRON- PRP$ cord-258021-xhx74vr6 40 42 diagnosis diagnosis NN cord-258021-xhx74vr6 40 43 . . . cord-258021-xhx74vr6 41 1 Because because IN cord-258021-xhx74vr6 41 2 Legionellae Legionellae NNP cord-258021-xhx74vr6 41 3 will will MD cord-258021-xhx74vr6 41 4 not not RB cord-258021-xhx74vr6 41 5 grow grow VB cord-258021-xhx74vr6 41 6 on on IN cord-258021-xhx74vr6 41 7 standard standard JJ cord-258021-xhx74vr6 41 8 culture culture NN cord-258021-xhx74vr6 41 9 media medium NNS cord-258021-xhx74vr6 41 10 , , , cord-258021-xhx74vr6 41 11 the the DT cord-258021-xhx74vr6 41 12 diagnosis diagnosis NN cord-258021-xhx74vr6 41 13 has have VBZ cord-258021-xhx74vr6 41 14 traditionally traditionally RB cord-258021-xhx74vr6 41 15 rested rest VBN cord-258021-xhx74vr6 41 16 on on IN cord-258021-xhx74vr6 41 17 either either DT cord-258021-xhx74vr6 41 18 positive positive JJ cord-258021-xhx74vr6 41 19 serology serology NN cord-258021-xhx74vr6 41 20 or or CC cord-258021-xhx74vr6 41 21 a a DT cord-258021-xhx74vr6 41 22 positive positive JJ cord-258021-xhx74vr6 41 23 urinary urinary JJ cord-258021-xhx74vr6 41 24 antigen antigen NN cord-258021-xhx74vr6 41 25 test test NN cord-258021-xhx74vr6 41 26 . . . cord-258021-xhx74vr6 42 1 Both both DT cord-258021-xhx74vr6 42 2 of of IN cord-258021-xhx74vr6 42 3 these these DT cord-258021-xhx74vr6 42 4 tests test NNS cord-258021-xhx74vr6 42 5 have have VBP cord-258021-xhx74vr6 42 6 significant significant JJ cord-258021-xhx74vr6 42 7 limitations limitation NNS cord-258021-xhx74vr6 42 8 . . . cord-258021-xhx74vr6 43 1 In in IN cord-258021-xhx74vr6 43 2 the the DT cord-258021-xhx74vr6 43 3 case case NN cord-258021-xhx74vr6 43 4 of of IN cord-258021-xhx74vr6 43 5 serology serology NN cord-258021-xhx74vr6 43 6 , , , cord-258021-xhx74vr6 43 7 20 20 CD cord-258021-xhx74vr6 43 8 % % NN cord-258021-xhx74vr6 43 9 or or CC cord-258021-xhx74vr6 43 10 more more JJR cord-258021-xhx74vr6 43 11 of of IN cord-258021-xhx74vr6 43 12 patients patient NNS cord-258021-xhx74vr6 43 13 with with IN cord-258021-xhx74vr6 43 14 culture culture NN cord-258021-xhx74vr6 43 15 - - HYPH cord-258021-xhx74vr6 43 16 proven prove VBN cord-258021-xhx74vr6 43 17 Legionella Legionella NNP cord-258021-xhx74vr6 43 18 infection infection NN cord-258021-xhx74vr6 43 19 do do VBP cord-258021-xhx74vr6 43 20 not not RB cord-258021-xhx74vr6 43 21 ever ever RB cord-258021-xhx74vr6 43 22 seroconvert seroconvert VB cord-258021-xhx74vr6 43 23 , , , cord-258021-xhx74vr6 43 24 19 19 CD cord-258021-xhx74vr6 43 25 , , , cord-258021-xhx74vr6 43 26 20 20 CD cord-258021-xhx74vr6 43 27 and and CC cord-258021-xhx74vr6 43 28 seroconversion seroconversion NN cord-258021-xhx74vr6 43 29 may may MD cord-258021-xhx74vr6 43 30 take take VB cord-258021-xhx74vr6 43 31 months month NNS cord-258021-xhx74vr6 43 32 , , , cord-258021-xhx74vr6 43 33 requiring require VBG cord-258021-xhx74vr6 43 34 testing testing NN cord-258021-xhx74vr6 43 35 out out RP cord-258021-xhx74vr6 43 36 to to IN cord-258021-xhx74vr6 43 37 at at RB cord-258021-xhx74vr6 43 38 least least RBS cord-258021-xhx74vr6 43 39 2 2 CD cord-258021-xhx74vr6 43 40 months month NNS cord-258021-xhx74vr6 43 41 if if IN cord-258021-xhx74vr6 43 42 not not RB cord-258021-xhx74vr6 43 43 longer long JJR cord-258021-xhx74vr6 43 44 . . . cord-258021-xhx74vr6 44 1 21 21 CD cord-258021-xhx74vr6 44 2 Urinary urinary JJ cord-258021-xhx74vr6 44 3 antigen antigen NN cord-258021-xhx74vr6 44 4 testing testing NN cord-258021-xhx74vr6 44 5 is be VBZ cord-258021-xhx74vr6 44 6 quite quite RB cord-258021-xhx74vr6 44 7 specific specific JJ cord-258021-xhx74vr6 44 8 , , , cord-258021-xhx74vr6 44 9 but but CC cord-258021-xhx74vr6 44 10 will will MD cord-258021-xhx74vr6 44 11 only only RB cord-258021-xhx74vr6 44 12 reliably reliably RB cord-258021-xhx74vr6 44 13 detection detection NN cord-258021-xhx74vr6 44 14 L L NNP cord-258021-xhx74vr6 44 15 pneumophila pneumophila NN cord-258021-xhx74vr6 44 16 serogroup serogroup NNP cord-258021-xhx74vr6 44 17 1 1 CD cord-258021-xhx74vr6 44 18 , , , cord-258021-xhx74vr6 44 19 and and CC cord-258021-xhx74vr6 44 20 usually usually RB cord-258021-xhx74vr6 44 21 serogroup serogroup NNP cord-258021-xhx74vr6 44 22 6 6 CD cord-258021-xhx74vr6 44 23 , , , cord-258021-xhx74vr6 44 24 but but CC cord-258021-xhx74vr6 44 25 in in IN cord-258021-xhx74vr6 44 26 many many JJ cord-258021-xhx74vr6 44 27 areas area NNS cord-258021-xhx74vr6 44 28 other other JJ cord-258021-xhx74vr6 44 29 species specie NNS cord-258021-xhx74vr6 44 30 ( ( -LRB- cord-258021-xhx74vr6 44 31 particularly particularly RB cord-258021-xhx74vr6 44 32 Legionella Legionella NNP cord-258021-xhx74vr6 44 33 longbeachae longbeachae NN cord-258021-xhx74vr6 44 34 and and CC cord-258021-xhx74vr6 44 35 Legionella Legionella NNP cord-258021-xhx74vr6 44 36 micdadei micdadei NNP cord-258021-xhx74vr6 44 37 ) ) -RRB- cord-258021-xhx74vr6 44 38 are be VBP cord-258021-xhx74vr6 44 39 more more RBR cord-258021-xhx74vr6 44 40 predominant predominant JJ cord-258021-xhx74vr6 44 41 . . . cord-258021-xhx74vr6 45 1 Despite despite IN cord-258021-xhx74vr6 45 2 these these DT cord-258021-xhx74vr6 45 3 limitations limitation NNS cord-258021-xhx74vr6 45 4 , , , cord-258021-xhx74vr6 45 5 urinary urinary JJ cord-258021-xhx74vr6 45 6 antigen antigen NN cord-258021-xhx74vr6 45 7 testing testing NN cord-258021-xhx74vr6 45 8 for for IN cord-258021-xhx74vr6 45 9 Legionella Legionella NNP cord-258021-xhx74vr6 45 10 is be VBZ cord-258021-xhx74vr6 45 11 recommended recommend VBN cord-258021-xhx74vr6 45 12 in in IN cord-258021-xhx74vr6 45 13 all all DT cord-258021-xhx74vr6 45 14 patients patient NNS cord-258021-xhx74vr6 45 15 with with IN cord-258021-xhx74vr6 45 16 severe severe JJ cord-258021-xhx74vr6 45 17 CAP cap NN cord-258021-xhx74vr6 45 18 ( ( -LRB- cord-258021-xhx74vr6 45 19 ie ie FW cord-258021-xhx74vr6 45 20 , , , cord-258021-xhx74vr6 45 21 admitted admit VBN cord-258021-xhx74vr6 45 22 to to IN cord-258021-xhx74vr6 45 23 the the DT cord-258021-xhx74vr6 45 24 intensive intensive JJ cord-258021-xhx74vr6 45 25 care care NN cord-258021-xhx74vr6 45 26 unit unit NN cord-258021-xhx74vr6 45 27 ) ) -RRB- cord-258021-xhx74vr6 45 28 for for IN cord-258021-xhx74vr6 45 29 both both CC cord-258021-xhx74vr6 45 30 diagnostic diagnostic JJ cord-258021-xhx74vr6 45 31 and and CC cord-258021-xhx74vr6 45 32 public public JJ cord-258021-xhx74vr6 45 33 health health NN cord-258021-xhx74vr6 45 34 reasons reason NNS cord-258021-xhx74vr6 45 35 . . . cord-258021-xhx74vr6 46 1 22 22 CD cord-258021-xhx74vr6 47 1 The the DT cord-258021-xhx74vr6 47 2 mainstay mainstay NN cord-258021-xhx74vr6 47 3 of of IN cord-258021-xhx74vr6 47 4 diagnosis diagnosis NN cord-258021-xhx74vr6 47 5 of of IN cord-258021-xhx74vr6 47 6 Legionella Legionella NNP cord-258021-xhx74vr6 47 7 infection infection NN cord-258021-xhx74vr6 47 8 has have VBZ cord-258021-xhx74vr6 47 9 been be VBN cord-258021-xhx74vr6 47 10 from from IN cord-258021-xhx74vr6 47 11 one one CD cord-258021-xhx74vr6 47 12 or or CC cord-258021-xhx74vr6 47 13 more more JJR cord-258021-xhx74vr6 47 14 of of IN cord-258021-xhx74vr6 47 15 direct direct JJ cord-258021-xhx74vr6 47 16 antigen antigen NN cord-258021-xhx74vr6 47 17 detection detection NN cord-258021-xhx74vr6 47 18 or or CC cord-258021-xhx74vr6 47 19 nucleic nucleic JJ cord-258021-xhx74vr6 47 20 acid acid NN cord-258021-xhx74vr6 47 21 detection detection NN cord-258021-xhx74vr6 47 22 in in IN cord-258021-xhx74vr6 47 23 respiratory respiratory JJ cord-258021-xhx74vr6 47 24 secretions secretion NNS cord-258021-xhx74vr6 47 25 . . . cord-258021-xhx74vr6 48 1 Direct direct JJ cord-258021-xhx74vr6 48 2 fluorescent fluorescent JJ cord-258021-xhx74vr6 48 3 antigen antigen NN cord-258021-xhx74vr6 48 4 detection detection NN cord-258021-xhx74vr6 48 5 was be VBD cord-258021-xhx74vr6 48 6 developed develop VBN cord-258021-xhx74vr6 48 7 in in IN cord-258021-xhx74vr6 48 8 the the DT cord-258021-xhx74vr6 48 9 pre pre JJ cord-258021-xhx74vr6 48 10 - - JJ cord-258021-xhx74vr6 48 11 PCR pcr NN cord-258021-xhx74vr6 48 12 era era NN cord-258021-xhx74vr6 48 13 but but CC cord-258021-xhx74vr6 48 14 have have VBP cord-258021-xhx74vr6 48 15 now now RB cord-258021-xhx74vr6 48 16 largely largely RB cord-258021-xhx74vr6 48 17 been be VBN cord-258021-xhx74vr6 48 18 replaced replace VBN cord-258021-xhx74vr6 48 19 by by IN cord-258021-xhx74vr6 48 20 PCR PCR NNP cord-258021-xhx74vr6 48 21 because because IN cord-258021-xhx74vr6 48 22 the the DT cord-258021-xhx74vr6 48 23 latter latter NN cord-258021-xhx74vr6 48 24 is be VBZ cord-258021-xhx74vr6 48 25 more more RBR cord-258021-xhx74vr6 48 26 sensitive sensitive JJ cord-258021-xhx74vr6 48 27 , , , cord-258021-xhx74vr6 48 28 less less JJR cord-258021-xhx74vr6 48 29 technician technician NN cord-258021-xhx74vr6 48 30 dependent dependent JJ cord-258021-xhx74vr6 48 31 , , , cord-258021-xhx74vr6 48 32 and and CC cord-258021-xhx74vr6 48 33 easier easy JJR cord-258021-xhx74vr6 48 34 to to TO cord-258021-xhx74vr6 48 35 automate automate VB cord-258021-xhx74vr6 48 36 . . . cord-258021-xhx74vr6 49 1 PCR PCR NNP cord-258021-xhx74vr6 49 2 tests test NNS cord-258021-xhx74vr6 49 3 for for IN cord-258021-xhx74vr6 49 4 Legionella Legionella NNP cord-258021-xhx74vr6 49 5 are be VBP cord-258021-xhx74vr6 49 6 a a DT cord-258021-xhx74vr6 49 7 mix mix NN cord-258021-xhx74vr6 49 8 of of IN cord-258021-xhx74vr6 49 9 " " `` cord-258021-xhx74vr6 49 10 home home RB cord-258021-xhx74vr6 49 11 - - HYPH cord-258021-xhx74vr6 49 12 grown grow VBN cord-258021-xhx74vr6 49 13 " " '' cord-258021-xhx74vr6 49 14 assays assay NNS cord-258021-xhx74vr6 49 15 and and CC cord-258021-xhx74vr6 49 16 commercially commercially RB cord-258021-xhx74vr6 49 17 available available JJ cord-258021-xhx74vr6 49 18 products product NNS cord-258021-xhx74vr6 49 19 , , , cord-258021-xhx74vr6 49 20 with with IN cord-258021-xhx74vr6 49 21 reported report VBN cord-258021-xhx74vr6 49 22 sensitivity sensitivity NN cord-258021-xhx74vr6 49 23 and and CC cord-258021-xhx74vr6 49 24 specificity specificity NN cord-258021-xhx74vr6 49 25 ( ( -LRB- cord-258021-xhx74vr6 49 26 using use VBG cord-258021-xhx74vr6 49 27 all all DT cord-258021-xhx74vr6 49 28 other other JJ cord-258021-xhx74vr6 49 29 tests test NNS cord-258021-xhx74vr6 49 30 as as IN cord-258021-xhx74vr6 49 31 the the DT cord-258021-xhx74vr6 49 32 gold gold NN cord-258021-xhx74vr6 49 33 standard standard NN cord-258021-xhx74vr6 49 34 ) ) -RRB- cord-258021-xhx74vr6 49 35 in in IN cord-258021-xhx74vr6 49 36 the the DT cord-258021-xhx74vr6 49 37 range range NN cord-258021-xhx74vr6 49 38 of of IN cord-258021-xhx74vr6 49 39 91 91 CD cord-258021-xhx74vr6 49 40 % % NN cord-258021-xhx74vr6 49 41 to to TO cord-258021-xhx74vr6 49 42 99 99 CD cord-258021-xhx74vr6 49 43 % % NN cord-258021-xhx74vr6 49 44 and and CC cord-258021-xhx74vr6 49 45 94 94 CD cord-258021-xhx74vr6 49 46 % % NN cord-258021-xhx74vr6 49 47 to to IN cord-258021-xhx74vr6 49 48 99 99 CD cord-258021-xhx74vr6 49 49 % % NN cord-258021-xhx74vr6 49 50 , , , cord-258021-xhx74vr6 49 51 respectively respectively RB cord-258021-xhx74vr6 49 52 . . . cord-258021-xhx74vr6 50 1 23 23 CD cord-258021-xhx74vr6 51 1 Because because IN cord-258021-xhx74vr6 51 2 PCR PCR NNP cord-258021-xhx74vr6 51 3 tests test NNS cord-258021-xhx74vr6 51 4 for for IN cord-258021-xhx74vr6 51 5 Legionella Legionella NNP cord-258021-xhx74vr6 51 6 are be VBP cord-258021-xhx74vr6 51 7 generally generally RB cord-258021-xhx74vr6 51 8 able able JJ cord-258021-xhx74vr6 51 9 to to TO cord-258021-xhx74vr6 51 10 detect detect VB cord-258021-xhx74vr6 51 11 all all DT cord-258021-xhx74vr6 51 12 species specie NNS cord-258021-xhx74vr6 51 13 , , , cord-258021-xhx74vr6 51 14 24 24 CD cord-258021-xhx74vr6 51 15 not not RB cord-258021-xhx74vr6 51 16 surprisingly surprisingly RB cord-258021-xhx74vr6 51 17 they -PRON- PRP cord-258021-xhx74vr6 51 18 have have VBP cord-258021-xhx74vr6 51 19 a a DT cord-258021-xhx74vr6 51 20 greater great JJR cord-258021-xhx74vr6 51 21 degree degree NN cord-258021-xhx74vr6 51 22 of of IN cord-258021-xhx74vr6 51 23 sensitivity sensitivity NN cord-258021-xhx74vr6 51 24 than than IN cord-258021-xhx74vr6 51 25 urinary urinary JJ cord-258021-xhx74vr6 51 26 antigen antigen NN cord-258021-xhx74vr6 51 27 testing testing NN cord-258021-xhx74vr6 51 28 . . . cord-258021-xhx74vr6 52 1 23 23 CD cord-258021-xhx74vr6 52 2 , , , cord-258021-xhx74vr6 52 3 25 25 CD cord-258021-xhx74vr6 52 4 There there EX cord-258021-xhx74vr6 52 5 is be VBZ cord-258021-xhx74vr6 52 6 , , , cord-258021-xhx74vr6 52 7 however however RB cord-258021-xhx74vr6 52 8 , , , cord-258021-xhx74vr6 52 9 a a DT cord-258021-xhx74vr6 52 10 reasonable reasonable JJ cord-258021-xhx74vr6 52 11 argument argument NN cord-258021-xhx74vr6 52 12 for for IN cord-258021-xhx74vr6 52 13 performing perform VBG cord-258021-xhx74vr6 52 14 both both DT cord-258021-xhx74vr6 52 15 urinary urinary JJ cord-258021-xhx74vr6 52 16 antigen antigen NN cord-258021-xhx74vr6 52 17 testing testing NN cord-258021-xhx74vr6 52 18 and and CC cord-258021-xhx74vr6 52 19 PCR PCR NNP cord-258021-xhx74vr6 52 20 on on IN cord-258021-xhx74vr6 52 21 respiratory respiratory JJ cord-258021-xhx74vr6 52 22 secretions secretion NNS cord-258021-xhx74vr6 52 23 because because IN cord-258021-xhx74vr6 52 24 there there EX cord-258021-xhx74vr6 52 25 is be VBZ cord-258021-xhx74vr6 52 26 an an DT cord-258021-xhx74vr6 52 27 increased increase VBN cord-258021-xhx74vr6 52 28 diagnostic diagnostic JJ cord-258021-xhx74vr6 52 29 yield yield NN cord-258021-xhx74vr6 52 30 from from IN cord-258021-xhx74vr6 52 31 this this DT cord-258021-xhx74vr6 52 32 approach approach NN cord-258021-xhx74vr6 52 33 . . . cord-258021-xhx74vr6 53 1 26 26 CD cord-258021-xhx74vr6 54 1 It -PRON- PRP cord-258021-xhx74vr6 54 2 is be VBZ cord-258021-xhx74vr6 54 3 worth worth JJ cord-258021-xhx74vr6 54 4 noting note VBG cord-258021-xhx74vr6 54 5 that that IN cord-258021-xhx74vr6 54 6 both both DT cord-258021-xhx74vr6 54 7 nasopharyngeal nasopharyngeal JJ cord-258021-xhx74vr6 54 8 aspirates aspirate NNS cord-258021-xhx74vr6 54 9 [ [ -LRB- cord-258021-xhx74vr6 54 10 27 27 CD cord-258021-xhx74vr6 54 11 ] ] -RRB- cord-258021-xhx74vr6 54 12 [ [ -LRB- cord-258021-xhx74vr6 54 13 28 28 CD cord-258021-xhx74vr6 54 14 ] ] -RRB- cord-258021-xhx74vr6 54 15 [ [ -LRB- cord-258021-xhx74vr6 54 16 29 29 CD cord-258021-xhx74vr6 54 17 ] ] -RRB- cord-258021-xhx74vr6 54 18 and and CC cord-258021-xhx74vr6 54 19 throat throat NN cord-258021-xhx74vr6 54 20 swabs swab NNS cord-258021-xhx74vr6 54 21 15 15 CD cord-258021-xhx74vr6 54 22 have have VBP cord-258021-xhx74vr6 54 23 substantially substantially RB cord-258021-xhx74vr6 54 24 lower low JJR cord-258021-xhx74vr6 54 25 yields yield NNS cord-258021-xhx74vr6 54 26 for for IN cord-258021-xhx74vr6 54 27 the the DT cord-258021-xhx74vr6 54 28 detection detection NN cord-258021-xhx74vr6 54 29 of of IN cord-258021-xhx74vr6 54 30 Legionella Legionella NNP cord-258021-xhx74vr6 54 31 by by IN cord-258021-xhx74vr6 54 32 PCR PCR NNP cord-258021-xhx74vr6 54 33 , , , cord-258021-xhx74vr6 54 34 but but CC cord-258021-xhx74vr6 54 35 may may MD cord-258021-xhx74vr6 54 36 be be VB cord-258021-xhx74vr6 54 37 of of IN cord-258021-xhx74vr6 54 38 use use NN cord-258021-xhx74vr6 54 39 in in IN cord-258021-xhx74vr6 54 40 patients patient NNS cord-258021-xhx74vr6 54 41 in in IN cord-258021-xhx74vr6 54 42 whom whom WP cord-258021-xhx74vr6 54 43 it -PRON- PRP cord-258021-xhx74vr6 54 44 is be VBZ cord-258021-xhx74vr6 54 45 not not RB cord-258021-xhx74vr6 54 46 possible possible JJ cord-258021-xhx74vr6 54 47 to to TO cord-258021-xhx74vr6 54 48 get get VB cord-258021-xhx74vr6 54 49 spontaneous spontaneous JJ cord-258021-xhx74vr6 54 50 or or CC cord-258021-xhx74vr6 54 51 induced induce VBN cord-258021-xhx74vr6 54 52 sputum sputum NN cord-258021-xhx74vr6 54 53 samples sample NNS cord-258021-xhx74vr6 54 54 . . . cord-258021-xhx74vr6 55 1 Traditionally traditionally RB cord-258021-xhx74vr6 55 2 , , , cord-258021-xhx74vr6 55 3 Mycoplasma mycoplasma NN cord-258021-xhx74vr6 55 4 infections infection NNS cord-258021-xhx74vr6 55 5 have have VBP cord-258021-xhx74vr6 55 6 most most RBS cord-258021-xhx74vr6 55 7 often often RB cord-258021-xhx74vr6 55 8 been be VBN cord-258021-xhx74vr6 55 9 diagnosed diagnose VBN cord-258021-xhx74vr6 55 10 on on IN cord-258021-xhx74vr6 55 11 the the DT cord-258021-xhx74vr6 55 12 basis basis NN cord-258021-xhx74vr6 55 13 of of IN cord-258021-xhx74vr6 55 14 serology serology NN cord-258021-xhx74vr6 55 15 ; ; : cord-258021-xhx74vr6 55 16 however however RB cord-258021-xhx74vr6 55 17 , , , cord-258021-xhx74vr6 55 18 as as IN cord-258021-xhx74vr6 55 19 with with IN cord-258021-xhx74vr6 55 20 serologic serologic JJ cord-258021-xhx74vr6 55 21 tests test NNS cord-258021-xhx74vr6 55 22 for for IN cord-258021-xhx74vr6 55 23 many many JJ cord-258021-xhx74vr6 55 24 pathogens pathogen NNS cord-258021-xhx74vr6 55 25 , , , cord-258021-xhx74vr6 55 26 this this DT cord-258021-xhx74vr6 55 27 has have VBZ cord-258021-xhx74vr6 55 28 significant significant JJ cord-258021-xhx74vr6 55 29 limitations limitation NNS cord-258021-xhx74vr6 55 30 early early RB cord-258021-xhx74vr6 55 31 in in IN cord-258021-xhx74vr6 55 32 disease disease NN cord-258021-xhx74vr6 55 33 when when WRB cord-258021-xhx74vr6 55 34 false false JJ cord-258021-xhx74vr6 55 35 - - HYPH cord-258021-xhx74vr6 55 36 negative negative JJ cord-258021-xhx74vr6 55 37 results result NNS cord-258021-xhx74vr6 55 38 are be VBP cord-258021-xhx74vr6 55 39 common common JJ cord-258021-xhx74vr6 55 40 . . . cord-258021-xhx74vr6 56 1 Difficulties difficulty NNS cord-258021-xhx74vr6 56 2 in in IN cord-258021-xhx74vr6 56 3 making make VBG cord-258021-xhx74vr6 56 4 the the DT cord-258021-xhx74vr6 56 5 diagnosis diagnosis NN cord-258021-xhx74vr6 56 6 as as RB cord-258021-xhx74vr6 56 7 well well RB cord-258021-xhx74vr6 56 8 as as IN cord-258021-xhx74vr6 56 9 the the DT cord-258021-xhx74vr6 56 10 marked marked JJ cord-258021-xhx74vr6 56 11 season season NN cord-258021-xhx74vr6 56 12 to to IN cord-258021-xhx74vr6 56 13 season season NN cord-258021-xhx74vr6 56 14 variation variation NN cord-258021-xhx74vr6 56 15 in in IN cord-258021-xhx74vr6 56 16 its -PRON- PRP$ cord-258021-xhx74vr6 56 17 prevalence prevalence NN cord-258021-xhx74vr6 56 18 probably probably RB cord-258021-xhx74vr6 56 19 explain explain VBP cord-258021-xhx74vr6 56 20 the the DT cord-258021-xhx74vr6 56 21 enormous enormous JJ cord-258021-xhx74vr6 56 22 variation variation NN cord-258021-xhx74vr6 56 23 in in IN cord-258021-xhx74vr6 56 24 the the DT cord-258021-xhx74vr6 56 25 estimated estimate VBN cord-258021-xhx74vr6 56 26 proportion proportion NN cord-258021-xhx74vr6 56 27 of of IN cord-258021-xhx74vr6 56 28 cases case NNS cord-258021-xhx74vr6 56 29 of of IN cord-258021-xhx74vr6 56 30 CAP cap NN cord-258021-xhx74vr6 56 31 owing owe VBG cord-258021-xhx74vr6 56 32 to to IN cord-258021-xhx74vr6 56 33 M M NNP cord-258021-xhx74vr6 56 34 pneumoniae pneumoniae NN cord-258021-xhx74vr6 56 35 , , , cord-258021-xhx74vr6 56 36 which which WDT cord-258021-xhx74vr6 56 37 range range VBP cord-258021-xhx74vr6 56 38 from from IN cord-258021-xhx74vr6 56 39 less less JJR cord-258021-xhx74vr6 56 40 than than IN cord-258021-xhx74vr6 56 41 1 1 CD cord-258021-xhx74vr6 56 42 % % NN cord-258021-xhx74vr6 56 43 to to IN cord-258021-xhx74vr6 56 44 greater great JJR cord-258021-xhx74vr6 56 45 than than IN cord-258021-xhx74vr6 56 46 50 50 CD cord-258021-xhx74vr6 56 47 % % NN cord-258021-xhx74vr6 56 48 . . . cord-258021-xhx74vr6 57 1 PCR PCR NNP cord-258021-xhx74vr6 57 2 does do VBZ cord-258021-xhx74vr6 57 3 overcome overcome VB cord-258021-xhx74vr6 57 4 some some DT cord-258021-xhx74vr6 57 5 of of IN cord-258021-xhx74vr6 57 6 the the DT cord-258021-xhx74vr6 57 7 limitations limitation NNS cord-258021-xhx74vr6 57 8 of of IN cord-258021-xhx74vr6 57 9 serology serology NN cord-258021-xhx74vr6 57 10 for for IN cord-258021-xhx74vr6 57 11 the the DT cord-258021-xhx74vr6 57 12 diagnosis diagnosis NN cord-258021-xhx74vr6 57 13 of of IN cord-258021-xhx74vr6 57 14 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 57 15 infection infection NN cord-258021-xhx74vr6 57 16 and and CC cord-258021-xhx74vr6 57 17 the the DT cord-258021-xhx74vr6 57 18 nuances nuance NNS cord-258021-xhx74vr6 57 19 of of IN cord-258021-xhx74vr6 57 20 assay assay NN cord-258021-xhx74vr6 57 21 development development NN cord-258021-xhx74vr6 57 22 and and CC cord-258021-xhx74vr6 57 23 relative relative JJ cord-258021-xhx74vr6 57 24 performance performance NN cord-258021-xhx74vr6 57 25 characteristics characteristic NNS cord-258021-xhx74vr6 57 26 has have VBZ cord-258021-xhx74vr6 57 27 been be VBN cord-258021-xhx74vr6 57 28 reviewed review VBN cord-258021-xhx74vr6 57 29 comprehensively comprehensively RB cord-258021-xhx74vr6 57 30 elsewhere elsewhere RB cord-258021-xhx74vr6 57 31 . . . cord-258021-xhx74vr6 58 1 30 30 CD cord-258021-xhx74vr6 59 1 The the DT cord-258021-xhx74vr6 59 2 performance performance NN cord-258021-xhx74vr6 59 3 characteristics characteristic NNS cord-258021-xhx74vr6 59 4 for for IN cord-258021-xhx74vr6 59 5 PCR PCR NNP cord-258021-xhx74vr6 59 6 assays assay NNS cord-258021-xhx74vr6 59 7 for for IN cord-258021-xhx74vr6 59 8 M M NNP cord-258021-xhx74vr6 59 9 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 59 10 seem seem VBP cord-258021-xhx74vr6 59 11 to to TO cord-258021-xhx74vr6 59 12 be be VB cord-258021-xhx74vr6 59 13 at at IN cord-258021-xhx74vr6 59 14 least least JJS cord-258021-xhx74vr6 59 15 as as RB cord-258021-xhx74vr6 59 16 good good JJ cord-258021-xhx74vr6 59 17 as as IN cord-258021-xhx74vr6 59 18 those those DT cord-258021-xhx74vr6 59 19 for for IN cord-258021-xhx74vr6 59 20 Legionella Legionella NNP cord-258021-xhx74vr6 59 21 infections infection NNS cord-258021-xhx74vr6 59 22 and and CC cord-258021-xhx74vr6 59 23 possibly possibly RB cord-258021-xhx74vr6 59 24 better well RBR cord-258021-xhx74vr6 59 25 . . . cord-258021-xhx74vr6 60 1 31 31 CD cord-258021-xhx74vr6 60 2 , , , cord-258021-xhx74vr6 60 3 32 32 CD cord-258021-xhx74vr6 61 1 As as IN cord-258021-xhx74vr6 61 2 with with IN cord-258021-xhx74vr6 61 3 other other JJ cord-258021-xhx74vr6 61 4 pathogens pathogen NNS cord-258021-xhx74vr6 61 5 , , , cord-258021-xhx74vr6 61 6 the the DT cord-258021-xhx74vr6 61 7 detection detection NN cord-258021-xhx74vr6 61 8 rate rate NN cord-258021-xhx74vr6 61 9 of of IN cord-258021-xhx74vr6 61 10 M M NNP cord-258021-xhx74vr6 61 11 pneumoniae pneumoniae NN cord-258021-xhx74vr6 61 12 using use VBG cord-258021-xhx74vr6 61 13 PCR PCR NNP cord-258021-xhx74vr6 61 14 on on IN cord-258021-xhx74vr6 61 15 nasopharyngeal nasopharyngeal JJ cord-258021-xhx74vr6 61 16 aspirates aspirate NNS cord-258021-xhx74vr6 61 17 is be VBZ cord-258021-xhx74vr6 61 18 lower low JJR cord-258021-xhx74vr6 61 19 than than IN cord-258021-xhx74vr6 61 20 in in IN cord-258021-xhx74vr6 61 21 sputum sputum NN cord-258021-xhx74vr6 61 22 samples sample NNS cord-258021-xhx74vr6 61 23 . . . cord-258021-xhx74vr6 62 1 28 28 CD cord-258021-xhx74vr6 63 1 Recently recently RB cord-258021-xhx74vr6 63 2 , , , cord-258021-xhx74vr6 63 3 there there EX cord-258021-xhx74vr6 63 4 has have VBZ cord-258021-xhx74vr6 63 5 been be VBN cord-258021-xhx74vr6 63 6 interest interest NN cord-258021-xhx74vr6 63 7 in in IN cord-258021-xhx74vr6 63 8 antigen antigen NN cord-258021-xhx74vr6 63 9 detection detection NN cord-258021-xhx74vr6 63 10 assays assay NNS cord-258021-xhx74vr6 63 11 for for IN cord-258021-xhx74vr6 63 12 the the DT cord-258021-xhx74vr6 63 13 diagnosis diagnosis NN cord-258021-xhx74vr6 63 14 of of IN cord-258021-xhx74vr6 63 15 M M NNP cord-258021-xhx74vr6 63 16 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 63 17 because because IN cord-258021-xhx74vr6 63 18 these these DT cord-258021-xhx74vr6 63 19 offer offer VBP cord-258021-xhx74vr6 63 20 the the DT cord-258021-xhx74vr6 63 21 potential potential NN cord-258021-xhx74vr6 63 22 for for IN cord-258021-xhx74vr6 63 23 point point NN cord-258021-xhx74vr6 63 24 - - HYPH cord-258021-xhx74vr6 63 25 of of IN cord-258021-xhx74vr6 63 26 - - HYPH cord-258021-xhx74vr6 63 27 care care NN cord-258021-xhx74vr6 63 28 testing testing NN cord-258021-xhx74vr6 63 29 , , , cord-258021-xhx74vr6 63 30 but but CC cord-258021-xhx74vr6 63 31 so so RB cord-258021-xhx74vr6 63 32 far far RB cord-258021-xhx74vr6 63 33 these these DT cord-258021-xhx74vr6 63 34 have have VBP cord-258021-xhx74vr6 63 35 yet yet RB cord-258021-xhx74vr6 63 36 to to TO cord-258021-xhx74vr6 63 37 enter enter VB cord-258021-xhx74vr6 63 38 the the DT cord-258021-xhx74vr6 63 39 clinical clinical JJ cord-258021-xhx74vr6 63 40 mainstream mainstream NN cord-258021-xhx74vr6 63 41 . . . cord-258021-xhx74vr6 64 1 33 33 CD cord-258021-xhx74vr6 64 2 , , , cord-258021-xhx74vr6 64 3 34 34 CD cord-258021-xhx74vr6 64 4 Chlamydophila chlamydophila NN cord-258021-xhx74vr6 65 1 The the DT cord-258021-xhx74vr6 65 2 nomenclature nomenclature NN cord-258021-xhx74vr6 65 3 for for IN cord-258021-xhx74vr6 65 4 the the DT cord-258021-xhx74vr6 65 5 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 65 6 has have VBZ cord-258021-xhx74vr6 65 7 changed change VBN cord-258021-xhx74vr6 65 8 recently recently RB cord-258021-xhx74vr6 65 9 with with IN cord-258021-xhx74vr6 65 10 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 65 11 and and CC cord-258021-xhx74vr6 65 12 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 65 13 being be VBG cord-258021-xhx74vr6 65 14 combined combine VBN cord-258021-xhx74vr6 65 15 back back RB cord-258021-xhx74vr6 65 16 into into IN cord-258021-xhx74vr6 65 17 a a DT cord-258021-xhx74vr6 65 18 single single JJ cord-258021-xhx74vr6 65 19 genus genus NN cord-258021-xhx74vr6 65 20 . . . cord-258021-xhx74vr6 66 1 35 35 CD cord-258021-xhx74vr6 67 1 Both both DT cord-258021-xhx74vr6 67 2 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 67 3 psittaci psittaci NN cord-258021-xhx74vr6 67 4 and and CC cord-258021-xhx74vr6 67 5 C C NNP cord-258021-xhx74vr6 67 6 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 67 7 are be VBP cord-258021-xhx74vr6 67 8 wellaccepted wellaccepte VBN cord-258021-xhx74vr6 67 9 as as IN cord-258021-xhx74vr6 67 10 causes cause NNS cord-258021-xhx74vr6 67 11 of of IN cord-258021-xhx74vr6 67 12 CAP cap NN cord-258021-xhx74vr6 67 13 , , , cord-258021-xhx74vr6 67 14 although although IN cord-258021-xhx74vr6 67 15 almost almost RB cord-258021-xhx74vr6 67 16 always always RB cord-258021-xhx74vr6 67 17 being be VBG cord-258021-xhx74vr6 67 18 identified identify VBN cord-258021-xhx74vr6 67 19 as as RB cord-258021-xhx74vr6 67 20 much much RB cord-258021-xhx74vr6 67 21 less less RBR cord-258021-xhx74vr6 67 22 common common JJ cord-258021-xhx74vr6 67 23 than than IN cord-258021-xhx74vr6 67 24 either either CC cord-258021-xhx74vr6 67 25 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 67 26 or or CC cord-258021-xhx74vr6 67 27 Legionella Legionella NNP cord-258021-xhx74vr6 67 28 infections infection NNS cord-258021-xhx74vr6 67 29 . . . cord-258021-xhx74vr6 68 1 A a DT cord-258021-xhx74vr6 68 2 number number NN cord-258021-xhx74vr6 68 3 of of IN cord-258021-xhx74vr6 68 4 other other JJ cord-258021-xhx74vr6 68 5 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 68 6 - - HYPH cord-258021-xhx74vr6 68 7 like like JJ cord-258021-xhx74vr6 68 8 pathogens pathogen NNS cord-258021-xhx74vr6 68 9 ( ( -LRB- cord-258021-xhx74vr6 68 10 such such JJ cord-258021-xhx74vr6 68 11 as as IN cord-258021-xhx74vr6 68 12 Parachlamydia Parachlamydia NNP cord-258021-xhx74vr6 68 13 acanthamoebae acanthamoebae NN cord-258021-xhx74vr6 68 14 and and CC cord-258021-xhx74vr6 68 15 Simkania Simkania NNP cord-258021-xhx74vr6 68 16 negevensis negevensis NNP cord-258021-xhx74vr6 68 17 ) ) -RRB- cord-258021-xhx74vr6 68 18 also also RB cord-258021-xhx74vr6 68 19 been be VBN cord-258021-xhx74vr6 68 20 suggested suggest VBN cord-258021-xhx74vr6 68 21 as as IN cord-258021-xhx74vr6 68 22 potential potential JJ cord-258021-xhx74vr6 68 23 causes cause NNS cord-258021-xhx74vr6 68 24 of of IN cord-258021-xhx74vr6 68 25 the the DT cord-258021-xhx74vr6 68 26 50 50 CD cord-258021-xhx74vr6 68 27 % % NN cord-258021-xhx74vr6 68 28 or or CC cord-258021-xhx74vr6 68 29 more more JJR cord-258021-xhx74vr6 68 30 of of IN cord-258021-xhx74vr6 68 31 cases case NNS cord-258021-xhx74vr6 68 32 of of IN cord-258021-xhx74vr6 68 33 CAP cap NN cord-258021-xhx74vr6 68 34 where where WRB cord-258021-xhx74vr6 68 35 no no DT cord-258021-xhx74vr6 68 36 pathogen pathogen NN cord-258021-xhx74vr6 68 37 is be VBZ cord-258021-xhx74vr6 68 38 identified identify VBN cord-258021-xhx74vr6 68 39 . . . cord-258021-xhx74vr6 69 1 36 36 CD cord-258021-xhx74vr6 69 2 , , , cord-258021-xhx74vr6 69 3 37 37 CD cord-258021-xhx74vr6 70 1 The the DT cord-258021-xhx74vr6 70 2 specificity specificity NN cord-258021-xhx74vr6 70 3 of of IN cord-258021-xhx74vr6 70 4 positive positive JJ cord-258021-xhx74vr6 70 5 serology serology NN cord-258021-xhx74vr6 70 6 for for IN cord-258021-xhx74vr6 70 7 C c NN cord-258021-xhx74vr6 70 8 pneumoniae pneumoniae NN cord-258021-xhx74vr6 70 9 has have VBZ cord-258021-xhx74vr6 70 10 also also RB cord-258021-xhx74vr6 70 11 been be VBN cord-258021-xhx74vr6 70 12 questioned question VBN cord-258021-xhx74vr6 70 13 , , , cord-258021-xhx74vr6 70 14 because because IN cord-258021-xhx74vr6 70 15 studies study NNS cord-258021-xhx74vr6 70 16 using use VBG cord-258021-xhx74vr6 70 17 PCR PCR NNP cord-258021-xhx74vr6 70 18 - - HYPH cord-258021-xhx74vr6 70 19 based base VBN cord-258021-xhx74vr6 70 20 diagnosis diagnosis NN cord-258021-xhx74vr6 70 21 typically typically RB cord-258021-xhx74vr6 70 22 find find VBP cord-258021-xhx74vr6 70 23 much much JJ cord-258021-xhx74vr6 70 24 lower low JJR cord-258021-xhx74vr6 70 25 rates rate NNS cord-258021-xhx74vr6 70 26 of of IN cord-258021-xhx74vr6 70 27 infection infection NN cord-258021-xhx74vr6 70 28 than than IN cord-258021-xhx74vr6 70 29 earlier early JJR cord-258021-xhx74vr6 70 30 serology serology NN cord-258021-xhx74vr6 70 31 - - HYPH cord-258021-xhx74vr6 70 32 based base VBN cord-258021-xhx74vr6 70 33 studies study NNS cord-258021-xhx74vr6 70 34 and and CC cord-258021-xhx74vr6 70 35 a a DT cord-258021-xhx74vr6 70 36 large large JJ cord-258021-xhx74vr6 70 37 variety variety NN cord-258021-xhx74vr6 70 38 of of IN cord-258021-xhx74vr6 70 39 assays assay NNS cord-258021-xhx74vr6 70 40 with with IN cord-258021-xhx74vr6 70 41 different different JJ cord-258021-xhx74vr6 70 42 performance performance NN cord-258021-xhx74vr6 70 43 characteristics characteristic NNS cord-258021-xhx74vr6 70 44 have have VBP cord-258021-xhx74vr6 70 45 been be VBN cord-258021-xhx74vr6 70 46 used use VBN cord-258021-xhx74vr6 70 47 . . . cord-258021-xhx74vr6 71 1 38 38 CD cord-258021-xhx74vr6 72 1 As as IN cord-258021-xhx74vr6 72 2 with with IN cord-258021-xhx74vr6 72 3 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 72 4 , , , cord-258021-xhx74vr6 72 5 in in IN cord-258021-xhx74vr6 72 6 early early JJ cord-258021-xhx74vr6 72 7 disease disease NN cord-258021-xhx74vr6 72 8 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 72 9 serology serology NN cord-258021-xhx74vr6 72 10 is be VBZ cord-258021-xhx74vr6 72 11 often often RB cord-258021-xhx74vr6 72 12 negative negative JJ cord-258021-xhx74vr6 72 13 making make VBG cord-258021-xhx74vr6 72 14 PCR PCR NNP cord-258021-xhx74vr6 72 15 a a DT cord-258021-xhx74vr6 72 16 superior superior JJ cord-258021-xhx74vr6 72 17 diagnostic diagnostic JJ cord-258021-xhx74vr6 72 18 test test NN cord-258021-xhx74vr6 72 19 . . . cord-258021-xhx74vr6 73 1 39 39 CD cord-258021-xhx74vr6 74 1 Unlike unlike IN cord-258021-xhx74vr6 74 2 Legionella Legionella NNP cord-258021-xhx74vr6 74 3 and and CC cord-258021-xhx74vr6 74 4 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 74 5 , , , cord-258021-xhx74vr6 74 6 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 74 7 can can MD cord-258021-xhx74vr6 74 8 not not RB cord-258021-xhx74vr6 74 9 be be VB cord-258021-xhx74vr6 74 10 detected detect VBN cord-258021-xhx74vr6 74 11 by by IN cord-258021-xhx74vr6 74 12 16S 16S NNP cord-258021-xhx74vr6 74 13 - - HYPH cord-258021-xhx74vr6 74 14 based base VBN cord-258021-xhx74vr6 74 15 PCR PCR NNP cord-258021-xhx74vr6 74 16 assays assay NNS cord-258021-xhx74vr6 74 17 . . . cord-258021-xhx74vr6 75 1 Because because IN cord-258021-xhx74vr6 75 2 culture culture NN cord-258021-xhx74vr6 75 3 of of IN cord-258021-xhx74vr6 75 4 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 75 5 is be VBZ cord-258021-xhx74vr6 75 6 difficult difficult JJ cord-258021-xhx74vr6 75 7 and and CC cord-258021-xhx74vr6 75 8 has have VBZ cord-258021-xhx74vr6 75 9 a a DT cord-258021-xhx74vr6 75 10 low low JJ cord-258021-xhx74vr6 75 11 yield yield NN cord-258021-xhx74vr6 75 12 , , , cord-258021-xhx74vr6 75 13 it -PRON- PRP cord-258021-xhx74vr6 75 14 is be VBZ cord-258021-xhx74vr6 75 15 rarely rarely RB cord-258021-xhx74vr6 75 16 done do VBN cord-258021-xhx74vr6 75 17 40 40 CD cord-258021-xhx74vr6 75 18 ; ; : cord-258021-xhx74vr6 75 19 therefore therefore RB cord-258021-xhx74vr6 75 20 , , , cord-258021-xhx74vr6 75 21 PCR PCR NNP cord-258021-xhx74vr6 75 22 assays assay NNS cord-258021-xhx74vr6 75 23 that that WDT cord-258021-xhx74vr6 75 24 have have VBP cord-258021-xhx74vr6 75 25 been be VBN cord-258021-xhx74vr6 75 26 developed develop VBN cord-258021-xhx74vr6 75 27 are be VBP cord-258021-xhx74vr6 75 28 generally generally RB cord-258021-xhx74vr6 75 29 compared compare VBN cord-258021-xhx74vr6 75 30 with with IN cord-258021-xhx74vr6 75 31 serologic serologic JJ cord-258021-xhx74vr6 75 32 tests test NNS cord-258021-xhx74vr6 75 33 , , , cord-258021-xhx74vr6 75 34 with with IN cord-258021-xhx74vr6 75 35 their -PRON- PRP$ cord-258021-xhx74vr6 75 36 known know VBN cord-258021-xhx74vr6 75 37 limitations limitation NNS cord-258021-xhx74vr6 75 38 as as IN cord-258021-xhx74vr6 75 39 discussed discuss VBN cord-258021-xhx74vr6 75 40 . . . cord-258021-xhx74vr6 76 1 The the DT cord-258021-xhx74vr6 76 2 true true JJ cord-258021-xhx74vr6 76 3 sensitivity sensitivity NN cord-258021-xhx74vr6 76 4 of of IN cord-258021-xhx74vr6 76 5 PCR PCR NNP cord-258021-xhx74vr6 76 6 for for IN cord-258021-xhx74vr6 76 7 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 76 8 species specie NNS cord-258021-xhx74vr6 76 9 is be VBZ cord-258021-xhx74vr6 76 10 , , , cord-258021-xhx74vr6 76 11 therefore therefore RB cord-258021-xhx74vr6 76 12 , , , cord-258021-xhx74vr6 76 13 unknown unknown JJ cord-258021-xhx74vr6 76 14 . . . cord-258021-xhx74vr6 77 1 However however RB cord-258021-xhx74vr6 77 2 the the DT cord-258021-xhx74vr6 77 3 reported report VBN cord-258021-xhx74vr6 77 4 specificity specificity NN cord-258021-xhx74vr6 77 5 of of IN cord-258021-xhx74vr6 77 6 most most JJS cord-258021-xhx74vr6 77 7 assays assay NNS cord-258021-xhx74vr6 77 8 is be VBZ cord-258021-xhx74vr6 77 9 well well JJ cord-258021-xhx74vr6 77 10 over over IN cord-258021-xhx74vr6 77 11 95 95 CD cord-258021-xhx74vr6 77 12 % % NN cord-258021-xhx74vr6 77 13 41 41 CD cord-258021-xhx74vr6 77 14 and and CC cord-258021-xhx74vr6 77 15 , , , cord-258021-xhx74vr6 77 16 therefore therefore RB cord-258021-xhx74vr6 77 17 , , , cord-258021-xhx74vr6 77 18 a a DT cord-258021-xhx74vr6 77 19 positive positive JJ cord-258021-xhx74vr6 77 20 result result NN cord-258021-xhx74vr6 77 21 in in IN cord-258021-xhx74vr6 77 22 the the DT cord-258021-xhx74vr6 77 23 right right JJ cord-258021-xhx74vr6 77 24 clinical clinical JJ cord-258021-xhx74vr6 77 25 context context NN cord-258021-xhx74vr6 77 26 should should MD cord-258021-xhx74vr6 77 27 be be VB cord-258021-xhx74vr6 77 28 acted act VBN cord-258021-xhx74vr6 77 29 on on IN cord-258021-xhx74vr6 77 30 . . . cord-258021-xhx74vr6 78 1 All all DT cord-258021-xhx74vr6 78 2 major major JJ cord-258021-xhx74vr6 78 3 etiologic etiologic JJ cord-258021-xhx74vr6 78 4 studies study NNS cord-258021-xhx74vr6 78 5 of of IN cord-258021-xhx74vr6 78 6 CAP CAP NNP cord-258021-xhx74vr6 78 7 have have VBP cord-258021-xhx74vr6 78 8 identified identify VBN cord-258021-xhx74vr6 78 9 influenza influenza NN cord-258021-xhx74vr6 78 10 as as IN cord-258021-xhx74vr6 78 11 a a DT cord-258021-xhx74vr6 78 12 significant significant JJ cord-258021-xhx74vr6 78 13 cause cause NN cord-258021-xhx74vr6 78 14 of of IN cord-258021-xhx74vr6 78 15 CAP cap NN cord-258021-xhx74vr6 78 16 , , , cord-258021-xhx74vr6 78 17 particularly particularly RB cord-258021-xhx74vr6 78 18 in in IN cord-258021-xhx74vr6 78 19 hospitalized hospitalize VBN cord-258021-xhx74vr6 78 20 patients patient NNS cord-258021-xhx74vr6 78 21 . . . cord-258021-xhx74vr6 79 1 Since since IN cord-258021-xhx74vr6 79 2 the the DT cord-258021-xhx74vr6 79 3 recent recent JJ cord-258021-xhx74vr6 79 4 H1N1 H1N1 NNP cord-258021-xhx74vr6 79 5 09 09 CD cord-258021-xhx74vr6 79 6 influenza influenza NN cord-258021-xhx74vr6 79 7 pandemic pandemic NN cord-258021-xhx74vr6 79 8 , , , cord-258021-xhx74vr6 79 9 there there EX cord-258021-xhx74vr6 79 10 is be VBZ cord-258021-xhx74vr6 79 11 evidence evidence NN cord-258021-xhx74vr6 79 12 that that IN cord-258021-xhx74vr6 79 13 the the DT cord-258021-xhx74vr6 79 14 use use NN cord-258021-xhx74vr6 79 15 of of IN cord-258021-xhx74vr6 79 16 empiric empiric JJ cord-258021-xhx74vr6 79 17 antiinfluenza antiinfluenza NNP cord-258021-xhx74vr6 79 18 therapy therapy NN cord-258021-xhx74vr6 79 19 in in IN cord-258021-xhx74vr6 79 20 the the DT cord-258021-xhx74vr6 79 21 setting setting NN cord-258021-xhx74vr6 79 22 of of IN cord-258021-xhx74vr6 79 23 CAP CAP NNP cord-258021-xhx74vr6 79 24 has have VBZ cord-258021-xhx74vr6 79 25 increased increase VBN cord-258021-xhx74vr6 79 26 significantly significantly RB cord-258021-xhx74vr6 79 27 , , , cord-258021-xhx74vr6 79 28 with with IN cord-258021-xhx74vr6 79 29 an an DT cord-258021-xhx74vr6 79 30 unclear unclear JJ cord-258021-xhx74vr6 79 31 impact impact NN cord-258021-xhx74vr6 79 32 on on IN cord-258021-xhx74vr6 79 33 outcome outcome NN cord-258021-xhx74vr6 79 34 . . . cord-258021-xhx74vr6 80 1 42 42 CD cord-258021-xhx74vr6 81 1 A a DT cord-258021-xhx74vr6 81 2 fast fast JJ cord-258021-xhx74vr6 81 3 and and CC cord-258021-xhx74vr6 81 4 reliable reliable JJ cord-258021-xhx74vr6 81 5 diagnostic diagnostic JJ cord-258021-xhx74vr6 81 6 test test NN cord-258021-xhx74vr6 81 7 for for IN cord-258021-xhx74vr6 81 8 influenza influenza NN cord-258021-xhx74vr6 81 9 is be VBZ cord-258021-xhx74vr6 81 10 , , , cord-258021-xhx74vr6 81 11 therefore therefore RB cord-258021-xhx74vr6 81 12 , , , cord-258021-xhx74vr6 81 13 attractive attractive JJ cord-258021-xhx74vr6 81 14 not not RB cord-258021-xhx74vr6 81 15 only only RB cord-258021-xhx74vr6 81 16 to to TO cord-258021-xhx74vr6 81 17 prescribe prescribe VB cord-258021-xhx74vr6 81 18 antivirals antiviral NNS cord-258021-xhx74vr6 81 19 appropriately appropriately RB cord-258021-xhx74vr6 81 20 ( ( -LRB- cord-258021-xhx74vr6 81 21 for for IN cord-258021-xhx74vr6 81 22 treatment treatment NN cord-258021-xhx74vr6 81 23 and and CC cord-258021-xhx74vr6 81 24 prophylaxis prophylaxis NN cord-258021-xhx74vr6 81 25 ) ) -RRB- cord-258021-xhx74vr6 81 26 , , , cord-258021-xhx74vr6 81 27 but but CC cord-258021-xhx74vr6 81 28 also also RB cord-258021-xhx74vr6 81 29 to to TO cord-258021-xhx74vr6 81 30 aid aid VB cord-258021-xhx74vr6 81 31 in in IN cord-258021-xhx74vr6 81 32 the the DT cord-258021-xhx74vr6 81 33 allocation allocation NN cord-258021-xhx74vr6 81 34 of of IN cord-258021-xhx74vr6 81 35 respiratory respiratory JJ cord-258021-xhx74vr6 81 36 isolation isolation NN cord-258021-xhx74vr6 81 37 beds bed NNS cord-258021-xhx74vr6 81 38 , , , cord-258021-xhx74vr6 81 39 which which WDT cord-258021-xhx74vr6 81 40 are be VBP cord-258021-xhx74vr6 81 41 often often RB cord-258021-xhx74vr6 81 42 in in IN cord-258021-xhx74vr6 81 43 limited limited JJ cord-258021-xhx74vr6 81 44 supply supply NN cord-258021-xhx74vr6 81 45 , , , cord-258021-xhx74vr6 81 46 especially especially RB cord-258021-xhx74vr6 81 47 in in IN cord-258021-xhx74vr6 81 48 influenza influenza NN cord-258021-xhx74vr6 81 49 season season NN cord-258021-xhx74vr6 81 50 . . . cord-258021-xhx74vr6 82 1 For for IN cord-258021-xhx74vr6 82 2 this this DT cord-258021-xhx74vr6 82 3 reason reason NN cord-258021-xhx74vr6 82 4 , , , cord-258021-xhx74vr6 82 5 the the DT cord-258021-xhx74vr6 82 6 diagnostic diagnostic JJ cord-258021-xhx74vr6 82 7 tools tool NNS cord-258021-xhx74vr6 82 8 available available JJ cord-258021-xhx74vr6 82 9 for for IN cord-258021-xhx74vr6 82 10 influenza influenza NN cord-258021-xhx74vr6 82 11 have have VBP cord-258021-xhx74vr6 82 12 significantly significantly RB cord-258021-xhx74vr6 82 13 outpaced outpace VBN cord-258021-xhx74vr6 82 14 those those DT cord-258021-xhx74vr6 82 15 for for IN cord-258021-xhx74vr6 82 16 the the DT cord-258021-xhx74vr6 82 17 other other JJ cord-258021-xhx74vr6 82 18 causes cause NNS cord-258021-xhx74vr6 82 19 of of IN cord-258021-xhx74vr6 82 20 atypical atypical JJ cord-258021-xhx74vr6 82 21 pneumonia pneumonia NN cord-258021-xhx74vr6 82 22 . . . cord-258021-xhx74vr6 83 1 In in IN cord-258021-xhx74vr6 83 2 the the DT cord-258021-xhx74vr6 83 3 United United NNP cord-258021-xhx74vr6 83 4 States States NNP cord-258021-xhx74vr6 83 5 , , , cord-258021-xhx74vr6 83 6 there there EX cord-258021-xhx74vr6 83 7 are be VBP cord-258021-xhx74vr6 83 8 more more JJR cord-258021-xhx74vr6 83 9 than than IN cord-258021-xhx74vr6 83 10 a a DT cord-258021-xhx74vr6 83 11 dozen dozen NN cord-258021-xhx74vr6 83 12 approved approve VBN cord-258021-xhx74vr6 83 13 rapid rapid JJ cord-258021-xhx74vr6 83 14 influenza influenza NN cord-258021-xhx74vr6 83 15 tests test NNS cord-258021-xhx74vr6 83 16 primarily primarily RB cord-258021-xhx74vr6 83 17 based base VBN cord-258021-xhx74vr6 83 18 on on IN cord-258021-xhx74vr6 83 19 the the DT cord-258021-xhx74vr6 83 20 detection detection NN cord-258021-xhx74vr6 83 21 of of IN cord-258021-xhx74vr6 83 22 influenza influenza NN cord-258021-xhx74vr6 83 23 antigens antigen NNS cord-258021-xhx74vr6 83 24 in in IN cord-258021-xhx74vr6 83 25 respiratory respiratory JJ cord-258021-xhx74vr6 83 26 samples sample NNS cord-258021-xhx74vr6 83 27 . . . cord-258021-xhx74vr6 84 1 Most most RBS cord-258021-xhx74vr6 84 2 available available JJ cord-258021-xhx74vr6 84 3 assays assay NNS cord-258021-xhx74vr6 84 4 have have VBP cord-258021-xhx74vr6 84 5 been be VBN cord-258021-xhx74vr6 84 6 compared compare VBN cord-258021-xhx74vr6 84 7 with with IN cord-258021-xhx74vr6 84 8 a a DT cord-258021-xhx74vr6 84 9 gold gold JJ cord-258021-xhx74vr6 84 10 standard standard NN cord-258021-xhx74vr6 84 11 of of IN cord-258021-xhx74vr6 84 12 real real JJ cord-258021-xhx74vr6 84 13 - - HYPH cord-258021-xhx74vr6 84 14 time time NN cord-258021-xhx74vr6 84 15 reverse reverse NN cord-258021-xhx74vr6 84 16 transcription transcription NN cord-258021-xhx74vr6 84 17 PCR PCR NNP cord-258021-xhx74vr6 84 18 in in IN cord-258021-xhx74vr6 84 19 the the DT cord-258021-xhx74vr6 84 20 same same JJ cord-258021-xhx74vr6 84 21 sample sample NN cord-258021-xhx74vr6 84 22 . . . cord-258021-xhx74vr6 85 1 The the DT cord-258021-xhx74vr6 85 2 sensitivity sensitivity NN cord-258021-xhx74vr6 85 3 of of IN cord-258021-xhx74vr6 85 4 these these DT cord-258021-xhx74vr6 85 5 assays assay NNS cord-258021-xhx74vr6 85 6 varies vary VBZ cord-258021-xhx74vr6 85 7 between between IN cord-258021-xhx74vr6 85 8 10 10 CD cord-258021-xhx74vr6 85 9 % % NN cord-258021-xhx74vr6 85 10 and and CC cord-258021-xhx74vr6 85 11 75 75 CD cord-258021-xhx74vr6 85 12 % % NN cord-258021-xhx74vr6 85 13 depending depend VBG cord-258021-xhx74vr6 85 14 on on IN cord-258021-xhx74vr6 85 15 age age NN cord-258021-xhx74vr6 85 16 , , , cord-258021-xhx74vr6 85 17 quality quality NN cord-258021-xhx74vr6 85 18 of of IN cord-258021-xhx74vr6 85 19 the the DT cord-258021-xhx74vr6 85 20 sample sample NN cord-258021-xhx74vr6 85 21 , , , cord-258021-xhx74vr6 85 22 and and CC cord-258021-xhx74vr6 85 23 duration duration NN cord-258021-xhx74vr6 85 24 of of IN cord-258021-xhx74vr6 85 25 symptoms symptom NNS cord-258021-xhx74vr6 85 26 . . . cord-258021-xhx74vr6 86 1 Complicating complicate VBG cord-258021-xhx74vr6 86 2 the the DT cord-258021-xhx74vr6 86 3 assessment assessment NN cord-258021-xhx74vr6 86 4 of of IN cord-258021-xhx74vr6 86 5 the the DT cord-258021-xhx74vr6 86 6 usefulness usefulness NN cord-258021-xhx74vr6 86 7 of of IN cord-258021-xhx74vr6 86 8 these these DT cord-258021-xhx74vr6 86 9 assays assay NNS cord-258021-xhx74vr6 86 10 is be VBZ cord-258021-xhx74vr6 86 11 that that IN cord-258021-xhx74vr6 86 12 the the DT cord-258021-xhx74vr6 86 13 performance performance NN cord-258021-xhx74vr6 86 14 seems seem VBZ cord-258021-xhx74vr6 86 15 to to TO cord-258021-xhx74vr6 86 16 vary vary VB cord-258021-xhx74vr6 86 17 between between IN cord-258021-xhx74vr6 86 18 influenza influenza NN cord-258021-xhx74vr6 86 19 strains strain NNS cord-258021-xhx74vr6 86 20 and and CC cord-258021-xhx74vr6 86 21 , , , cord-258021-xhx74vr6 86 22 unfortunately unfortunately RB cord-258021-xhx74vr6 86 23 , , , cord-258021-xhx74vr6 86 24 during during IN cord-258021-xhx74vr6 86 25 the the DT cord-258021-xhx74vr6 86 26 H1N1 H1N1 NNP cord-258021-xhx74vr6 86 27 09 09 CD cord-258021-xhx74vr6 86 28 pandemic pandemic NN cord-258021-xhx74vr6 86 29 they -PRON- PRP cord-258021-xhx74vr6 86 30 were be VBD cord-258021-xhx74vr6 86 31 less less JJR cord-258021-xhx74vr6 86 32 than than IN cord-258021-xhx74vr6 86 33 optimal optimal JJ cord-258021-xhx74vr6 86 34 . . . cord-258021-xhx74vr6 87 1 43 43 CD cord-258021-xhx74vr6 87 2 - - SYM cord-258021-xhx74vr6 87 3 47 47 CD cord-258021-xhx74vr6 88 1 A a DT cord-258021-xhx74vr6 88 2 recent recent JJ cord-258021-xhx74vr6 88 3 metaanalysis metaanalysis NN cord-258021-xhx74vr6 88 4 of of IN cord-258021-xhx74vr6 88 5 159 159 CD cord-258021-xhx74vr6 88 6 published publish VBN cord-258021-xhx74vr6 88 7 studies study NNS cord-258021-xhx74vr6 88 8 of of IN cord-258021-xhx74vr6 88 9 rapid rapid JJ cord-258021-xhx74vr6 88 10 influenza influenza NN cord-258021-xhx74vr6 88 11 tests test NNS cord-258021-xhx74vr6 88 12 found find VBD cord-258021-xhx74vr6 88 13 the the DT cord-258021-xhx74vr6 88 14 pooled pool VBN cord-258021-xhx74vr6 88 15 sensitivity sensitivity NN cord-258021-xhx74vr6 88 16 , , , cord-258021-xhx74vr6 88 17 sensitivity sensitivity NN cord-258021-xhx74vr6 88 18 , , , cord-258021-xhx74vr6 88 19 specificity specificity NN cord-258021-xhx74vr6 88 20 , , , cord-258021-xhx74vr6 88 21 and and CC cord-258021-xhx74vr6 88 22 positive positive JJ cord-258021-xhx74vr6 88 23 and and CC cord-258021-xhx74vr6 88 24 negative negative JJ cord-258021-xhx74vr6 88 25 predictive predictive JJ cord-258021-xhx74vr6 88 26 values value NNS cord-258021-xhx74vr6 88 27 to to TO cord-258021-xhx74vr6 88 28 be be VB cord-258021-xhx74vr6 88 29 62 62 CD cord-258021-xhx74vr6 88 30 % % NN cord-258021-xhx74vr6 88 31 , , , cord-258021-xhx74vr6 88 32 98 98 CD cord-258021-xhx74vr6 88 33 % % NN cord-258021-xhx74vr6 88 34 , , , cord-258021-xhx74vr6 88 35 34 34 CD cord-258021-xhx74vr6 88 36 % % NN cord-258021-xhx74vr6 88 37 , , , cord-258021-xhx74vr6 88 38 and and CC cord-258021-xhx74vr6 88 39 38 38 CD cord-258021-xhx74vr6 88 40 % % NN cord-258021-xhx74vr6 88 41 , , , cord-258021-xhx74vr6 88 42 respectively respectively RB cord-258021-xhx74vr6 88 43 . . . cord-258021-xhx74vr6 89 1 47 47 CD cord-258021-xhx74vr6 90 1 Not not RB cord-258021-xhx74vr6 90 2 surprisingly surprisingly RB cord-258021-xhx74vr6 90 3 , , , cord-258021-xhx74vr6 90 4 given give VBN cord-258021-xhx74vr6 90 5 these these DT cord-258021-xhx74vr6 90 6 data datum NNS cord-258021-xhx74vr6 90 7 , , , cord-258021-xhx74vr6 90 8 there there EX cord-258021-xhx74vr6 90 9 is be VBZ cord-258021-xhx74vr6 90 10 little little JJ cord-258021-xhx74vr6 90 11 evidence evidence NN cord-258021-xhx74vr6 90 12 that that IN cord-258021-xhx74vr6 90 13 rapid rapid JJ cord-258021-xhx74vr6 90 14 influenza influenza NN cord-258021-xhx74vr6 90 15 tests test NNS cord-258021-xhx74vr6 90 16 are be VBP cord-258021-xhx74vr6 90 17 currently currently RB cord-258021-xhx74vr6 90 18 used use VBN cord-258021-xhx74vr6 90 19 by by IN cord-258021-xhx74vr6 90 20 clinicians clinician NNS cord-258021-xhx74vr6 90 21 to to TO cord-258021-xhx74vr6 90 22 alter alter VB cord-258021-xhx74vr6 90 23 patient patient JJ cord-258021-xhx74vr6 90 24 management management NN cord-258021-xhx74vr6 90 25 . . . cord-258021-xhx74vr6 91 1 48 48 CD cord-258021-xhx74vr6 92 1 However however RB cord-258021-xhx74vr6 92 2 , , , cord-258021-xhx74vr6 92 3 this this DT cord-258021-xhx74vr6 92 4 is be VBZ cord-258021-xhx74vr6 92 5 a a DT cord-258021-xhx74vr6 92 6 rapidly rapidly RB cord-258021-xhx74vr6 92 7 changing change VBG cord-258021-xhx74vr6 92 8 field field NN cord-258021-xhx74vr6 92 9 and and CC cord-258021-xhx74vr6 92 10 more more JJR cord-258021-xhx74vr6 92 11 recent recent JJ cord-258021-xhx74vr6 92 12 publications publication NNS cord-258021-xhx74vr6 92 13 suggest suggest VBP cord-258021-xhx74vr6 92 14 that that IN cord-258021-xhx74vr6 92 15 there there EX cord-258021-xhx74vr6 92 16 are be VBP cord-258021-xhx74vr6 92 17 incremental incremental JJ cord-258021-xhx74vr6 92 18 improvements improvement NNS cord-258021-xhx74vr6 92 19 with with IN cord-258021-xhx74vr6 92 20 a a DT cord-258021-xhx74vr6 92 21 range range NN cord-258021-xhx74vr6 92 22 of of IN cord-258021-xhx74vr6 92 23 sensitivity sensitivity NN cord-258021-xhx74vr6 92 24 from from IN cord-258021-xhx74vr6 92 25 68 68 CD cord-258021-xhx74vr6 92 26 % % NN cord-258021-xhx74vr6 92 27 to to IN cord-258021-xhx74vr6 92 28 79 79 CD cord-258021-xhx74vr6 92 29 % % NN cord-258021-xhx74vr6 92 30 and and CC cord-258021-xhx74vr6 92 31 specificity specificity NN cord-258021-xhx74vr6 92 32 of of IN cord-258021-xhx74vr6 92 33 99 99 CD cord-258021-xhx74vr6 92 34 % % NN cord-258021-xhx74vr6 92 35 to to TO cord-258021-xhx74vr6 92 36 100 100 CD cord-258021-xhx74vr6 92 37 % % NN cord-258021-xhx74vr6 92 38 . . . cord-258021-xhx74vr6 93 1 [ [ -LRB- cord-258021-xhx74vr6 93 2 49 49 CD cord-258021-xhx74vr6 93 3 ] ] -RRB- cord-258021-xhx74vr6 93 4 [ [ -LRB- cord-258021-xhx74vr6 93 5 50 50 CD cord-258021-xhx74vr6 93 6 ] ] -RRB- cord-258021-xhx74vr6 94 1 [ [ -LRB- cord-258021-xhx74vr6 94 2 51 51 CD cord-258021-xhx74vr6 94 3 ] ] -RRB- cord-258021-xhx74vr6 95 1 This this DT cord-258021-xhx74vr6 95 2 is be VBZ cord-258021-xhx74vr6 95 3 clearly clearly RB cord-258021-xhx74vr6 95 4 an an DT cord-258021-xhx74vr6 95 5 area area NN cord-258021-xhx74vr6 95 6 where where WRB cord-258021-xhx74vr6 95 7 we -PRON- PRP cord-258021-xhx74vr6 95 8 can can MD cord-258021-xhx74vr6 95 9 expect expect VB cord-258021-xhx74vr6 95 10 to to TO cord-258021-xhx74vr6 95 11 see see VB cord-258021-xhx74vr6 95 12 significant significant JJ cord-258021-xhx74vr6 95 13 advances advance NNS cord-258021-xhx74vr6 95 14 over over IN cord-258021-xhx74vr6 95 15 the the DT cord-258021-xhx74vr6 95 16 next next JJ cord-258021-xhx74vr6 95 17 few few JJ cord-258021-xhx74vr6 95 18 years year NNS cord-258021-xhx74vr6 95 19 . . . cord-258021-xhx74vr6 96 1 In in IN cord-258021-xhx74vr6 96 2 the the DT cord-258021-xhx74vr6 96 3 absence absence NN cord-258021-xhx74vr6 96 4 of of IN cord-258021-xhx74vr6 96 5 rapid rapid JJ cord-258021-xhx74vr6 96 6 diagnostic diagnostic JJ cord-258021-xhx74vr6 96 7 tests test NNS cord-258021-xhx74vr6 96 8 , , , cord-258021-xhx74vr6 96 9 existing exist VBG cord-258021-xhx74vr6 96 10 commercial commercial JJ cord-258021-xhx74vr6 96 11 PCR PCR NNP cord-258021-xhx74vr6 96 12 assays assay NNS cord-258021-xhx74vr6 96 13 for for IN cord-258021-xhx74vr6 96 14 influenza influenza NN cord-258021-xhx74vr6 96 15 have have VBP cord-258021-xhx74vr6 96 16 well well RB cord-258021-xhx74vr6 96 17 - - HYPH cord-258021-xhx74vr6 96 18 documented document VBN cord-258021-xhx74vr6 96 19 good good JJ cord-258021-xhx74vr6 96 20 performance performance NN cord-258021-xhx74vr6 96 21 characteristics characteristic NNS cord-258021-xhx74vr6 96 22 for for IN cord-258021-xhx74vr6 96 23 influenza influenza NN cord-258021-xhx74vr6 96 24 A a NN cord-258021-xhx74vr6 96 25 and and CC cord-258021-xhx74vr6 96 26 B b NN cord-258021-xhx74vr6 96 27 , , , cord-258021-xhx74vr6 96 28 and and CC cord-258021-xhx74vr6 96 29 these these DT cord-258021-xhx74vr6 96 30 data datum NNS cord-258021-xhx74vr6 96 31 are be VBP cord-258021-xhx74vr6 96 32 well well RB cord-258021-xhx74vr6 96 33 - - HYPH cord-258021-xhx74vr6 96 34 reviewed review VBN cord-258021-xhx74vr6 96 35 elsewhere elsewhere RB cord-258021-xhx74vr6 96 36 . . . cord-258021-xhx74vr6 97 1 52 52 CD cord-258021-xhx74vr6 98 1 What what WP cord-258021-xhx74vr6 98 2 is be VBZ cord-258021-xhx74vr6 98 3 interesting interesting JJ cord-258021-xhx74vr6 98 4 from from IN cord-258021-xhx74vr6 98 5 etiologic etiologic NNP cord-258021-xhx74vr6 98 6 studies study NNS cord-258021-xhx74vr6 98 7 is be VBZ cord-258021-xhx74vr6 98 8 the the DT cord-258021-xhx74vr6 98 9 high high JJ cord-258021-xhx74vr6 98 10 degree degree NN cord-258021-xhx74vr6 98 11 of of IN cord-258021-xhx74vr6 98 12 copathogen copathogen NN cord-258021-xhx74vr6 98 13 involvement involvement NN cord-258021-xhx74vr6 98 14 with with IN cord-258021-xhx74vr6 98 15 influenza influenza NN cord-258021-xhx74vr6 98 16 , , , cord-258021-xhx74vr6 98 17 particularly particularly RB cord-258021-xhx74vr6 98 18 the the DT cord-258021-xhx74vr6 98 19 codetection codetection NN cord-258021-xhx74vr6 98 20 of of IN cord-258021-xhx74vr6 98 21 bacterial bacterial JJ cord-258021-xhx74vr6 98 22 infection infection NN cord-258021-xhx74vr6 98 23 with with IN cord-258021-xhx74vr6 98 24 S s NN cord-258021-xhx74vr6 98 25 pneumoniae pneumoniae NN cord-258021-xhx74vr6 98 26 . . . cord-258021-xhx74vr6 99 1 2 2 LS cord-258021-xhx74vr6 99 2 , , , cord-258021-xhx74vr6 99 3 3 3 CD cord-258021-xhx74vr6 99 4 Whether whether IN cord-258021-xhx74vr6 99 5 this this DT cord-258021-xhx74vr6 99 6 is be VBZ cord-258021-xhx74vr6 99 7 genuine genuine JJ cord-258021-xhx74vr6 99 8 coinfection coinfection NN cord-258021-xhx74vr6 99 9 or or CC cord-258021-xhx74vr6 99 10 sequential sequential JJ cord-258021-xhx74vr6 99 11 infection infection NN cord-258021-xhx74vr6 99 12 is be VBZ cord-258021-xhx74vr6 99 13 a a DT cord-258021-xhx74vr6 99 14 current current JJ cord-258021-xhx74vr6 99 15 controversy controversy NN cord-258021-xhx74vr6 99 16 and and CC cord-258021-xhx74vr6 99 17 major major JJ cord-258021-xhx74vr6 99 18 area area NN cord-258021-xhx74vr6 99 19 of of IN cord-258021-xhx74vr6 99 20 research research NN cord-258021-xhx74vr6 99 21 interest interest NN cord-258021-xhx74vr6 99 22 . . . cord-258021-xhx74vr6 100 1 Unlike unlike IN cord-258021-xhx74vr6 100 2 bacterial bacterial JJ cord-258021-xhx74vr6 100 3 pathogens pathogen NNS cord-258021-xhx74vr6 100 4 , , , cord-258021-xhx74vr6 100 5 the the DT cord-258021-xhx74vr6 100 6 constant constant JJ cord-258021-xhx74vr6 100 7 genomic genomic JJ cord-258021-xhx74vr6 100 8 shifts shift NNS cord-258021-xhx74vr6 100 9 in in IN cord-258021-xhx74vr6 100 10 influenza influenza NN cord-258021-xhx74vr6 100 11 A A NNP cord-258021-xhx74vr6 100 12 do do VBP cord-258021-xhx74vr6 100 13 affect affect VB cord-258021-xhx74vr6 100 14 the the DT cord-258021-xhx74vr6 100 15 performance performance NN cord-258021-xhx74vr6 100 16 of of IN cord-258021-xhx74vr6 100 17 assays assay NNS cord-258021-xhx74vr6 100 18 and and CC cord-258021-xhx74vr6 100 19 they -PRON- PRP cord-258021-xhx74vr6 100 20 need need VBP cord-258021-xhx74vr6 100 21 to to TO cord-258021-xhx74vr6 100 22 be be VB cord-258021-xhx74vr6 100 23 revalidated revalidate VBN cord-258021-xhx74vr6 100 24 constantly constantly RB cord-258021-xhx74vr6 100 25 as as IN cord-258021-xhx74vr6 100 26 new new JJ cord-258021-xhx74vr6 100 27 strains strain NNS cord-258021-xhx74vr6 100 28 appear appear VBP cord-258021-xhx74vr6 100 29 . . . cord-258021-xhx74vr6 101 1 53 53 CD cord-258021-xhx74vr6 102 1 A a DT cord-258021-xhx74vr6 102 2 variety variety NN cord-258021-xhx74vr6 102 3 of of IN cord-258021-xhx74vr6 102 4 point point NN cord-258021-xhx74vr6 102 5 - - HYPH cord-258021-xhx74vr6 102 6 of of IN cord-258021-xhx74vr6 102 7 - - HYPH cord-258021-xhx74vr6 102 8 care care NN cord-258021-xhx74vr6 102 9 platforms platform NNS cord-258021-xhx74vr6 102 10 have have VBP cord-258021-xhx74vr6 102 11 been be VBN cord-258021-xhx74vr6 102 12 developed develop VBN cord-258021-xhx74vr6 102 13 for for IN cord-258021-xhx74vr6 102 14 detecting detect VBG cord-258021-xhx74vr6 102 15 influenza influenza NN cord-258021-xhx74vr6 102 16 , , , cord-258021-xhx74vr6 102 17 of of IN cord-258021-xhx74vr6 102 18 which which WDT cord-258021-xhx74vr6 102 19 the the DT cord-258021-xhx74vr6 102 20 GeneXpert GeneXpert NNP cord-258021-xhx74vr6 102 21 system system NN cord-258021-xhx74vr6 102 22 ( ( -LRB- cord-258021-xhx74vr6 102 23 Cepheid Cepheid NNP cord-258021-xhx74vr6 102 24 , , , cord-258021-xhx74vr6 102 25 Sunnyvale Sunnyvale NNP cord-258021-xhx74vr6 102 26 , , , cord-258021-xhx74vr6 102 27 CA CA NNP cord-258021-xhx74vr6 102 28 ) ) -RRB- cord-258021-xhx74vr6 102 29 is be VBZ cord-258021-xhx74vr6 102 30 perhaps perhaps RB cord-258021-xhx74vr6 102 31 so so RB cord-258021-xhx74vr6 102 32 far far RB cord-258021-xhx74vr6 102 33 the the DT cord-258021-xhx74vr6 102 34 best well RBS cord-258021-xhx74vr6 102 35 studied study VBN cord-258021-xhx74vr6 102 36 . . . cord-258021-xhx74vr6 103 1 54 54 CD cord-258021-xhx74vr6 104 1 GeneXpert GeneXpert NNP cord-258021-xhx74vr6 104 2 is be VBZ cord-258021-xhx74vr6 104 3 an an DT cord-258021-xhx74vr6 104 4 " " `` cord-258021-xhx74vr6 104 5 all all DT cord-258021-xhx74vr6 104 6 - - HYPH cord-258021-xhx74vr6 104 7 in in IN cord-258021-xhx74vr6 104 8 - - HYPH cord-258021-xhx74vr6 104 9 one one CD cord-258021-xhx74vr6 104 10 " " '' cord-258021-xhx74vr6 104 11 platform platform NN cord-258021-xhx74vr6 104 12 requiring require VBG cord-258021-xhx74vr6 104 13 minimal minimal JJ cord-258021-xhx74vr6 104 14 technical technical JJ cord-258021-xhx74vr6 104 15 expertise expertise NN cord-258021-xhx74vr6 104 16 , , , cord-258021-xhx74vr6 104 17 and and CC cord-258021-xhx74vr6 104 18 is be VBZ cord-258021-xhx74vr6 104 19 a a DT cord-258021-xhx74vr6 104 20 potential potential JJ cord-258021-xhx74vr6 104 21 point point NN cord-258021-xhx74vr6 104 22 - - HYPH cord-258021-xhx74vr6 104 23 of of IN cord-258021-xhx74vr6 104 24 - - HYPH cord-258021-xhx74vr6 104 25 care care NN cord-258021-xhx74vr6 104 26 platform platform NN cord-258021-xhx74vr6 104 27 for for IN cord-258021-xhx74vr6 104 28 diagnosing diagnose VBG cord-258021-xhx74vr6 104 29 influenza influenza NN cord-258021-xhx74vr6 104 30 . . . cord-258021-xhx74vr6 105 1 A a DT cord-258021-xhx74vr6 105 2 sputum sputum NN cord-258021-xhx74vr6 105 3 sample sample NN cord-258021-xhx74vr6 105 4 is be VBZ cord-258021-xhx74vr6 105 5 placed place VBN cord-258021-xhx74vr6 105 6 in in IN cord-258021-xhx74vr6 105 7 a a DT cord-258021-xhx74vr6 105 8 cartridge cartridge NN cord-258021-xhx74vr6 105 9 that that WDT cord-258021-xhx74vr6 105 10 plugs plug VBZ cord-258021-xhx74vr6 105 11 into into IN cord-258021-xhx74vr6 105 12 the the DT cord-258021-xhx74vr6 105 13 platform platform NN cord-258021-xhx74vr6 105 14 without without IN cord-258021-xhx74vr6 105 15 the the DT cord-258021-xhx74vr6 105 16 need need NN cord-258021-xhx74vr6 105 17 for for IN cord-258021-xhx74vr6 105 18 further further JJ cord-258021-xhx74vr6 105 19 processing processing NN cord-258021-xhx74vr6 105 20 or or CC cord-258021-xhx74vr6 105 21 expert expert JJ cord-258021-xhx74vr6 105 22 microbiological microbiological JJ cord-258021-xhx74vr6 105 23 assistance assistance NN cord-258021-xhx74vr6 105 24 . . . cord-258021-xhx74vr6 106 1 With with IN cord-258021-xhx74vr6 106 2 a a DT cord-258021-xhx74vr6 106 3 turnaround turnaround NN cord-258021-xhx74vr6 106 4 time time NN cord-258021-xhx74vr6 106 5 of of IN cord-258021-xhx74vr6 106 6 less less JJR cord-258021-xhx74vr6 106 7 than than IN cord-258021-xhx74vr6 106 8 2 2 CD cord-258021-xhx74vr6 106 9 hours hour NNS cord-258021-xhx74vr6 106 10 , , , cord-258021-xhx74vr6 106 11 results result NNS cord-258021-xhx74vr6 106 12 can can MD cord-258021-xhx74vr6 106 13 be be VB cord-258021-xhx74vr6 106 14 available available JJ cord-258021-xhx74vr6 106 15 fast fast JJ cord-258021-xhx74vr6 106 16 enough enough RB cord-258021-xhx74vr6 106 17 to to TO cord-258021-xhx74vr6 106 18 impact impact VB cord-258021-xhx74vr6 106 19 on on IN cord-258021-xhx74vr6 106 20 empiric empiric JJ cord-258021-xhx74vr6 106 21 therapy therapy NN cord-258021-xhx74vr6 106 22 . . . cord-258021-xhx74vr6 107 1 This this DT cord-258021-xhx74vr6 107 2 system system NN cord-258021-xhx74vr6 107 3 has have VBZ cord-258021-xhx74vr6 107 4 been be VBN cord-258021-xhx74vr6 107 5 evaluated evaluate VBN cord-258021-xhx74vr6 107 6 extensively extensively RB cord-258021-xhx74vr6 107 7 for for IN cord-258021-xhx74vr6 107 8 the the DT cord-258021-xhx74vr6 107 9 diagnosis diagnosis NN cord-258021-xhx74vr6 107 10 of of IN cord-258021-xhx74vr6 107 11 tuberculosis tuberculosis NN cord-258021-xhx74vr6 107 12 , , , cord-258021-xhx74vr6 107 13 including include VBG cord-258021-xhx74vr6 107 14 multidrug multidrug NN cord-258021-xhx74vr6 107 15 - - HYPH cord-258021-xhx74vr6 107 16 resistant resistant JJ cord-258021-xhx74vr6 107 17 tuberculosis tuberculosis NN cord-258021-xhx74vr6 107 18 , , , cord-258021-xhx74vr6 107 19 where where WRB cord-258021-xhx74vr6 107 20 it -PRON- PRP cord-258021-xhx74vr6 107 21 has have VBZ cord-258021-xhx74vr6 107 22 been be VBN cord-258021-xhx74vr6 107 23 proven prove VBN cord-258021-xhx74vr6 107 24 to to TO cord-258021-xhx74vr6 107 25 have have VB cord-258021-xhx74vr6 107 26 excellent excellent JJ cord-258021-xhx74vr6 107 27 sensitivity sensitivity NN cord-258021-xhx74vr6 107 28 and and CC cord-258021-xhx74vr6 107 29 specificity specificity NN cord-258021-xhx74vr6 107 30 . . . cord-258021-xhx74vr6 108 1 55 55 CD cord-258021-xhx74vr6 109 1 The the DT cord-258021-xhx74vr6 109 2 influenza influenza NN cord-258021-xhx74vr6 109 3 A a NN cord-258021-xhx74vr6 109 4 and and CC cord-258021-xhx74vr6 109 5 B B NNP cord-258021-xhx74vr6 109 6 GeneXpert GeneXpert NNP cord-258021-xhx74vr6 109 7 assay assay NN cord-258021-xhx74vr6 109 8 has have VBZ cord-258021-xhx74vr6 109 9 been be VBN cord-258021-xhx74vr6 109 10 evaluated evaluate VBN cord-258021-xhx74vr6 109 11 in in IN cord-258021-xhx74vr6 109 12 comparison comparison NN cord-258021-xhx74vr6 109 13 to to IN cord-258021-xhx74vr6 109 14 a a DT cord-258021-xhx74vr6 109 15 number number NN cord-258021-xhx74vr6 109 16 of of IN cord-258021-xhx74vr6 109 17 commercially commercially RB cord-258021-xhx74vr6 109 18 available available JJ cord-258021-xhx74vr6 109 19 rapid rapid JJ cord-258021-xhx74vr6 109 20 antigen antigen NN cord-258021-xhx74vr6 109 21 tests test NNS cord-258021-xhx74vr6 109 22 and and CC cord-258021-xhx74vr6 109 23 PCR PCR NNP cord-258021-xhx74vr6 109 24 tests test NNS cord-258021-xhx74vr6 109 25 and and CC cord-258021-xhx74vr6 109 26 found find VBD cord-258021-xhx74vr6 109 27 to to TO cord-258021-xhx74vr6 109 28 have have VB cord-258021-xhx74vr6 109 29 excellent excellent JJ cord-258021-xhx74vr6 109 30 sensitivity sensitivity NN cord-258021-xhx74vr6 109 31 ( ( -LRB- cord-258021-xhx74vr6 109 32 97 97 CD cord-258021-xhx74vr6 109 33 % % NN cord-258021-xhx74vr6 109 34 À100 à100 CD cord-258021-xhx74vr6 109 35 % % NN cord-258021-xhx74vr6 109 36 ) ) -RRB- cord-258021-xhx74vr6 109 37 and and CC cord-258021-xhx74vr6 109 38 specificity specificity NN cord-258021-xhx74vr6 109 39 ( ( -LRB- cord-258021-xhx74vr6 109 40 99%-100 99%-100 CD cord-258021-xhx74vr6 109 41 % % NN cord-258021-xhx74vr6 109 42 ) ) -RRB- cord-258021-xhx74vr6 109 43 . . . cord-258021-xhx74vr6 110 1 [ [ -LRB- cord-258021-xhx74vr6 110 2 56 56 CD cord-258021-xhx74vr6 110 3 ] ] -RRB- cord-258021-xhx74vr6 110 4 [ [ -LRB- cord-258021-xhx74vr6 110 5 57 57 CD cord-258021-xhx74vr6 110 6 ] ] -RRB- cord-258021-xhx74vr6 110 7 [ [ -LRB- cord-258021-xhx74vr6 110 8 58 58 CD cord-258021-xhx74vr6 110 9 ] ] -RRB- cord-258021-xhx74vr6 111 1 [ [ -LRB- cord-258021-xhx74vr6 111 2 59 59 CD cord-258021-xhx74vr6 111 3 ] ] -RRB- cord-258021-xhx74vr6 112 1 [ [ -LRB- cord-258021-xhx74vr6 112 2 60 60 CD cord-258021-xhx74vr6 112 3 ] ] -RRB- cord-258021-xhx74vr6 113 1 The the DT cord-258021-xhx74vr6 113 2 potential potential JJ cord-258021-xhx74vr6 113 3 clinical clinical JJ cord-258021-xhx74vr6 113 4 usefulness usefulness NN cord-258021-xhx74vr6 113 5 has have VBZ cord-258021-xhx74vr6 113 6 been be VBN cord-258021-xhx74vr6 113 7 studied study VBN cord-258021-xhx74vr6 113 8 in in IN cord-258021-xhx74vr6 113 9 the the DT cord-258021-xhx74vr6 113 10 emergency emergency NN cord-258021-xhx74vr6 113 11 department department NN cord-258021-xhx74vr6 113 12 setting setting NN cord-258021-xhx74vr6 113 13 , , , cord-258021-xhx74vr6 113 14 again again RB cord-258021-xhx74vr6 113 15 with with IN cord-258021-xhx74vr6 113 16 good good JJ cord-258021-xhx74vr6 113 17 performance performance NN cord-258021-xhx74vr6 113 18 and and CC cord-258021-xhx74vr6 113 19 efficiency efficiency NN cord-258021-xhx74vr6 113 20 . . . cord-258021-xhx74vr6 114 1 61 61 CD cord-258021-xhx74vr6 114 2 , , , cord-258021-xhx74vr6 114 3 62 62 CD cord-258021-xhx74vr6 114 4 Point point NN cord-258021-xhx74vr6 114 5 - - HYPH cord-258021-xhx74vr6 114 6 of of IN cord-258021-xhx74vr6 114 7 - - HYPH cord-258021-xhx74vr6 114 8 care care NN cord-258021-xhx74vr6 114 9 testing testing NN cord-258021-xhx74vr6 114 10 for for IN cord-258021-xhx74vr6 114 11 influenza influenza NN cord-258021-xhx74vr6 114 12 is be VBZ cord-258021-xhx74vr6 114 13 a a DT cord-258021-xhx74vr6 114 14 highly highly RB cord-258021-xhx74vr6 114 15 competitive competitive JJ cord-258021-xhx74vr6 114 16 area area NN cord-258021-xhx74vr6 114 17 with with IN cord-258021-xhx74vr6 114 18 potential potential JJ cord-258021-xhx74vr6 114 19 new new JJ cord-258021-xhx74vr6 114 20 products product NNS cord-258021-xhx74vr6 114 21 regularly regularly RB cord-258021-xhx74vr6 114 22 entering enter VBG cord-258021-xhx74vr6 114 23 the the DT cord-258021-xhx74vr6 114 24 market market NN cord-258021-xhx74vr6 114 25 offering offer VBG cord-258021-xhx74vr6 114 26 greater great JJR cord-258021-xhx74vr6 114 27 speed speed NN cord-258021-xhx74vr6 114 28 , , , cord-258021-xhx74vr6 114 29 lower low JJR cord-258021-xhx74vr6 114 30 cost cost NN cord-258021-xhx74vr6 114 31 , , , cord-258021-xhx74vr6 114 32 and/or and/or CC cord-258021-xhx74vr6 114 33 greater great JJR cord-258021-xhx74vr6 114 34 accuracy accuracy NN cord-258021-xhx74vr6 114 35 ( ( -LRB- cord-258021-xhx74vr6 114 36 for for IN cord-258021-xhx74vr6 114 37 example example NN cord-258021-xhx74vr6 114 38 [ [ -LRB- cord-258021-xhx74vr6 114 39 63 63 CD cord-258021-xhx74vr6 114 40 ] ] -RRB- cord-258021-xhx74vr6 114 41 [ [ -LRB- cord-258021-xhx74vr6 114 42 64 64 CD cord-258021-xhx74vr6 114 43 ] ] -RRB- cord-258021-xhx74vr6 114 44 [ [ -LRB- cord-258021-xhx74vr6 114 45 65 65 CD cord-258021-xhx74vr6 114 46 ] ] -RRB- cord-258021-xhx74vr6 114 47 [ [ -LRB- cord-258021-xhx74vr6 114 48 66 66 CD cord-258021-xhx74vr6 114 49 ] ] -RRB- cord-258021-xhx74vr6 114 50 ) ) -RRB- cord-258021-xhx74vr6 114 51 . . . cord-258021-xhx74vr6 115 1 A a DT cord-258021-xhx74vr6 115 2 large large JJ cord-258021-xhx74vr6 115 3 number number NN cord-258021-xhx74vr6 115 4 of of IN cord-258021-xhx74vr6 115 5 other other JJ cord-258021-xhx74vr6 115 6 viruses virus NNS cord-258021-xhx74vr6 115 7 are be VBP cord-258021-xhx74vr6 115 8 well well RB cord-258021-xhx74vr6 115 9 - - HYPH cord-258021-xhx74vr6 115 10 known know VBN cord-258021-xhx74vr6 115 11 to to TO cord-258021-xhx74vr6 115 12 cause cause VB cord-258021-xhx74vr6 115 13 pneumonia pneumonia NN cord-258021-xhx74vr6 115 14 , , , cord-258021-xhx74vr6 115 15 with with IN cord-258021-xhx74vr6 115 16 the the DT cord-258021-xhx74vr6 115 17 most most RBS cord-258021-xhx74vr6 115 18 common common JJ cord-258021-xhx74vr6 115 19 being be VBG cord-258021-xhx74vr6 115 20 adenovirus adenovirus NN cord-258021-xhx74vr6 115 21 , , , cord-258021-xhx74vr6 115 22 respiratory respiratory JJ cord-258021-xhx74vr6 115 23 syncytial syncytial JJ cord-258021-xhx74vr6 115 24 virus virus NN cord-258021-xhx74vr6 115 25 , , , cord-258021-xhx74vr6 115 26 metapneumonvirus metapneumonvirus NNP cord-258021-xhx74vr6 115 27 , , , cord-258021-xhx74vr6 115 28 parainfluenza parainfluenza NNP cord-258021-xhx74vr6 115 29 , , , cord-258021-xhx74vr6 115 30 and and CC cord-258021-xhx74vr6 115 31 coronaviruses coronaviruse NNS cord-258021-xhx74vr6 115 32 . . . cord-258021-xhx74vr6 116 1 In in IN cord-258021-xhx74vr6 116 2 the the DT cord-258021-xhx74vr6 116 3 absence absence NN cord-258021-xhx74vr6 116 4 of of IN cord-258021-xhx74vr6 116 5 specific specific JJ cord-258021-xhx74vr6 116 6 treatments treatment NNS cord-258021-xhx74vr6 116 7 for for IN cord-258021-xhx74vr6 116 8 any any DT cord-258021-xhx74vr6 116 9 of of IN cord-258021-xhx74vr6 116 10 these these DT cord-258021-xhx74vr6 116 11 viruses virus NNS cord-258021-xhx74vr6 116 12 , , , cord-258021-xhx74vr6 116 13 discussion discussion NN cord-258021-xhx74vr6 116 14 of of IN cord-258021-xhx74vr6 116 15 specific specific JJ cord-258021-xhx74vr6 116 16 diagnostic diagnostic JJ cord-258021-xhx74vr6 116 17 tests test NNS cord-258021-xhx74vr6 116 18 is be VBZ cord-258021-xhx74vr6 116 19 relatively relatively RB cord-258021-xhx74vr6 116 20 superfluous superfluous JJ cord-258021-xhx74vr6 116 21 ; ; : cord-258021-xhx74vr6 116 22 however however RB cord-258021-xhx74vr6 116 23 , , , cord-258021-xhx74vr6 116 24 many many JJ cord-258021-xhx74vr6 116 25 of of IN cord-258021-xhx74vr6 116 26 the the DT cord-258021-xhx74vr6 116 27 multipathogen multipathogen NN cord-258021-xhx74vr6 116 28 approaches approach NNS cord-258021-xhx74vr6 116 29 are be VBP cord-258021-xhx74vr6 116 30 discussed discuss VBN cord-258021-xhx74vr6 116 31 herein herein RB cord-258021-xhx74vr6 116 32 and and CC cord-258021-xhx74vr6 116 33 include include VBP cord-258021-xhx74vr6 116 34 1 1 CD cord-258021-xhx74vr6 116 35 or or CC cord-258021-xhx74vr6 116 36 more more JJR cord-258021-xhx74vr6 116 37 of of IN cord-258021-xhx74vr6 116 38 these these DT cord-258021-xhx74vr6 116 39 viruses virus NNS cord-258021-xhx74vr6 116 40 in in IN cord-258021-xhx74vr6 116 41 their -PRON- PRP$ cord-258021-xhx74vr6 116 42 " " `` cord-258021-xhx74vr6 116 43 panels panel NNS cord-258021-xhx74vr6 116 44 . . . cord-258021-xhx74vr6 116 45 " " '' cord-258021-xhx74vr6 117 1 With with IN cord-258021-xhx74vr6 117 2 an an DT cord-258021-xhx74vr6 117 3 ever ever RB cord-258021-xhx74vr6 117 4 - - HYPH cord-258021-xhx74vr6 117 5 expanding expand VBG cord-258021-xhx74vr6 117 6 list list NN cord-258021-xhx74vr6 117 7 of of IN cord-258021-xhx74vr6 117 8 pneumonia pneumonia NN cord-258021-xhx74vr6 117 9 - - HYPH cord-258021-xhx74vr6 117 10 causing cause VBG cord-258021-xhx74vr6 117 11 pathogens pathogen NNS cord-258021-xhx74vr6 117 12 , , , cord-258021-xhx74vr6 117 13 it -PRON- PRP cord-258021-xhx74vr6 117 14 is be VBZ cord-258021-xhx74vr6 117 15 both both DT cord-258021-xhx74vr6 117 16 time time NN cord-258021-xhx74vr6 117 17 consuming consume VBG cord-258021-xhx74vr6 117 18 and and CC cord-258021-xhx74vr6 117 19 expensive expensive JJ cord-258021-xhx74vr6 117 20 to to TO cord-258021-xhx74vr6 117 21 test test VB cord-258021-xhx74vr6 117 22 for for IN cord-258021-xhx74vr6 117 23 each each DT cord-258021-xhx74vr6 117 24 organism organism NN cord-258021-xhx74vr6 117 25 individually individually RB cord-258021-xhx74vr6 117 26 . . . cord-258021-xhx74vr6 118 1 The the DT cord-258021-xhx74vr6 118 2 ability ability NN cord-258021-xhx74vr6 118 3 to to TO cord-258021-xhx74vr6 118 4 detect detect VB cord-258021-xhx74vr6 118 5 multiple multiple JJ cord-258021-xhx74vr6 118 6 pathogens pathogen NNS cord-258021-xhx74vr6 118 7 in in IN cord-258021-xhx74vr6 118 8 a a DT cord-258021-xhx74vr6 118 9 single single JJ cord-258021-xhx74vr6 118 10 test test NN cord-258021-xhx74vr6 118 11 is be VBZ cord-258021-xhx74vr6 118 12 , , , cord-258021-xhx74vr6 118 13 therefore therefore RB cord-258021-xhx74vr6 118 14 , , , cord-258021-xhx74vr6 118 15 highly highly RB cord-258021-xhx74vr6 118 16 appealing appealing JJ cord-258021-xhx74vr6 118 17 and and CC cord-258021-xhx74vr6 118 18 has have VBZ cord-258021-xhx74vr6 118 19 been be VBN cord-258021-xhx74vr6 118 20 the the DT cord-258021-xhx74vr6 118 21 subject subject NN cord-258021-xhx74vr6 118 22 of of IN cord-258021-xhx74vr6 118 23 significant significant JJ cord-258021-xhx74vr6 118 24 research research NN cord-258021-xhx74vr6 118 25 , , , cord-258021-xhx74vr6 118 26 development development NN cord-258021-xhx74vr6 118 27 , , , cord-258021-xhx74vr6 118 28 and and CC cord-258021-xhx74vr6 118 29 validation validation NN cord-258021-xhx74vr6 118 30 in in IN cord-258021-xhx74vr6 118 31 the the DT cord-258021-xhx74vr6 118 32 setting setting NN cord-258021-xhx74vr6 118 33 of of IN cord-258021-xhx74vr6 118 34 respiratory respiratory JJ cord-258021-xhx74vr6 118 35 tract tract NN cord-258021-xhx74vr6 118 36 infection infection NN cord-258021-xhx74vr6 118 37 . . . cord-258021-xhx74vr6 119 1 Starting start VBG cord-258021-xhx74vr6 119 2 with with IN cord-258021-xhx74vr6 119 3 " " `` cord-258021-xhx74vr6 119 4 home home RB cord-258021-xhx74vr6 119 5 - - HYPH cord-258021-xhx74vr6 119 6 grown grow VBN cord-258021-xhx74vr6 119 7 " " '' cord-258021-xhx74vr6 119 8 multiplex multiplex JJ cord-258021-xhx74vr6 119 9 PCR pcr NN cord-258021-xhx74vr6 119 10 assays assay NNS cord-258021-xhx74vr6 119 11 , , , cord-258021-xhx74vr6 119 12 a a DT cord-258021-xhx74vr6 119 13 variety variety NN cord-258021-xhx74vr6 119 14 of of IN cord-258021-xhx74vr6 119 15 new new JJ cord-258021-xhx74vr6 119 16 platforms platform NNS cord-258021-xhx74vr6 119 17 have have VBP cord-258021-xhx74vr6 119 18 been be VBN cord-258021-xhx74vr6 119 19 developed develop VBN cord-258021-xhx74vr6 119 20 to to TO cord-258021-xhx74vr6 119 21 speed speed VB cord-258021-xhx74vr6 119 22 up up RP cord-258021-xhx74vr6 119 23 pathogen pathogen NN cord-258021-xhx74vr6 119 24 identification identification NN cord-258021-xhx74vr6 119 25 , , , cord-258021-xhx74vr6 119 26 and and CC cord-258021-xhx74vr6 119 27 in in IN cord-258021-xhx74vr6 119 28 some some DT cord-258021-xhx74vr6 119 29 cases case NNS cord-258021-xhx74vr6 119 30 combining combine VBG cord-258021-xhx74vr6 119 31 this this DT cord-258021-xhx74vr6 119 32 with with IN cord-258021-xhx74vr6 119 33 antibiotic antibiotic JJ cord-258021-xhx74vr6 119 34 sensitivity sensitivity NN cord-258021-xhx74vr6 119 35 testing testing NN cord-258021-xhx74vr6 119 36 . . . cord-258021-xhx74vr6 120 1 Because because IN cord-258021-xhx74vr6 120 2 the the DT cord-258021-xhx74vr6 120 3 focus focus NN cord-258021-xhx74vr6 120 4 of of IN cord-258021-xhx74vr6 120 5 multipathogen multipathogen NNP cord-258021-xhx74vr6 120 6 detection detection NN cord-258021-xhx74vr6 120 7 tools tool NNS cord-258021-xhx74vr6 120 8 is be VBZ cord-258021-xhx74vr6 120 9 to to TO cord-258021-xhx74vr6 120 10 find find VB cord-258021-xhx74vr6 120 11 the the DT cord-258021-xhx74vr6 120 12 cause cause NN cord-258021-xhx74vr6 120 13 of of IN cord-258021-xhx74vr6 120 14 the the DT cord-258021-xhx74vr6 120 15 pneumonia pneumonia NN cord-258021-xhx74vr6 120 16 , , , cord-258021-xhx74vr6 120 17 they -PRON- PRP cord-258021-xhx74vr6 120 18 all all DT cord-258021-xhx74vr6 120 19 combine combine VBP cord-258021-xhx74vr6 120 20 assays assay NNS cord-258021-xhx74vr6 120 21 for for IN cord-258021-xhx74vr6 120 22 " " `` cord-258021-xhx74vr6 120 23 typical typical JJ cord-258021-xhx74vr6 120 24 " " '' cord-258021-xhx74vr6 120 25 pathogens pathogen NNS cord-258021-xhx74vr6 120 26 such such JJ cord-258021-xhx74vr6 120 27 as as IN cord-258021-xhx74vr6 120 28 S S NNP cord-258021-xhx74vr6 120 29 pneumoniae pneumoniae NN cord-258021-xhx74vr6 120 30 with with IN cord-258021-xhx74vr6 120 31 the the DT cord-258021-xhx74vr6 120 32 " " `` cord-258021-xhx74vr6 120 33 atypical atypical JJ cord-258021-xhx74vr6 120 34 " " '' cord-258021-xhx74vr6 120 35 pathogens pathogen NNS cord-258021-xhx74vr6 120 36 . . . cord-258021-xhx74vr6 121 1 Multipathogen Multipathogen NNP cord-258021-xhx74vr6 121 2 detection detection NN cord-258021-xhx74vr6 121 3 systems system NNS cord-258021-xhx74vr6 121 4 can can MD cord-258021-xhx74vr6 121 5 in in IN cord-258021-xhx74vr6 121 6 general general JJ cord-258021-xhx74vr6 121 7 these these DT cord-258021-xhx74vr6 121 8 can can MD cord-258021-xhx74vr6 121 9 be be VB cord-258021-xhx74vr6 121 10 categorized categorize VBN cord-258021-xhx74vr6 121 11 into into IN cord-258021-xhx74vr6 121 12 those those DT cord-258021-xhx74vr6 121 13 specifically specifically RB cord-258021-xhx74vr6 121 14 designed design VBN cord-258021-xhx74vr6 121 15 to to TO cord-258021-xhx74vr6 121 16 speed speed VB cord-258021-xhx74vr6 121 17 up up RP cord-258021-xhx74vr6 121 18 pathogen pathogen NN cord-258021-xhx74vr6 121 19 recognition recognition NN cord-258021-xhx74vr6 121 20 from from IN cord-258021-xhx74vr6 121 21 positive positive JJ cord-258021-xhx74vr6 121 22 blood blood NN cord-258021-xhx74vr6 121 23 cultures culture NNS cord-258021-xhx74vr6 121 24 ( ( -LRB- cord-258021-xhx74vr6 121 25 eg eg IN cord-258021-xhx74vr6 121 26 , , , cord-258021-xhx74vr6 121 27 including include VBG cord-258021-xhx74vr6 121 28 systems system NNS cord-258021-xhx74vr6 121 29 such such JJ cord-258021-xhx74vr6 121 30 as as IN cord-258021-xhx74vr6 121 31 The the DT cord-258021-xhx74vr6 121 32 Verigene Verigene NNP cord-258021-xhx74vr6 121 33 GramPositive GramPositive NNP cord-258021-xhx74vr6 121 34 Blood blood NN cord-258021-xhx74vr6 121 35 Culture culture NN cord-258021-xhx74vr6 121 36 Nucleic Nucleic NNP cord-258021-xhx74vr6 121 37 Acid acid NN cord-258021-xhx74vr6 121 38 Test test NN cord-258021-xhx74vr6 121 39 ; ; : cord-258021-xhx74vr6 121 40 Nanosphere Nanosphere NNP cord-258021-xhx74vr6 121 41 , , , cord-258021-xhx74vr6 121 42 Northbrook Northbrook NNP cord-258021-xhx74vr6 121 43 , , , cord-258021-xhx74vr6 121 44 IL IL NNP cord-258021-xhx74vr6 121 45 ) ) -RRB- cord-258021-xhx74vr6 122 1 , , , cord-258021-xhx74vr6 122 2 Prove prove NN cord-258021-xhx74vr6 122 3 - - : cord-258021-xhx74vr6 122 4 it -PRON- PRP cord-258021-xhx74vr6 123 1 Sepsis Sepsis NNP cord-258021-xhx74vr6 123 2 StripArray StripArray NNP cord-258021-xhx74vr6 123 3 technology technology NN cord-258021-xhx74vr6 123 4 ( ( -LRB- cord-258021-xhx74vr6 123 5 Mobidiag Mobidiag NNP cord-258021-xhx74vr6 123 6 , , , cord-258021-xhx74vr6 123 7 Espoo Espoo NNP cord-258021-xhx74vr6 123 8 , , , cord-258021-xhx74vr6 123 9 Finland Finland NNP cord-258021-xhx74vr6 123 10 ) ) -RRB- cord-258021-xhx74vr6 123 11 , , , cord-258021-xhx74vr6 123 12 and and CC cord-258021-xhx74vr6 123 13 FilmArray FilmArray NNP cord-258021-xhx74vr6 123 14 ( ( -LRB- cord-258021-xhx74vr6 123 15 BioFire BioFire NNP cord-258021-xhx74vr6 123 16 Diagnostics Diagnostics NNPS cord-258021-xhx74vr6 123 17 , , , cord-258021-xhx74vr6 123 18 Salt Salt NNP cord-258021-xhx74vr6 123 19 Lake Lake NNP cord-258021-xhx74vr6 123 20 City City NNP cord-258021-xhx74vr6 123 21 , , , cord-258021-xhx74vr6 123 22 UT UT NNP cord-258021-xhx74vr6 123 23 ) ) -RRB- cord-258021-xhx74vr6 123 24 , , , cord-258021-xhx74vr6 123 25 and and CC cord-258021-xhx74vr6 123 26 those those DT cord-258021-xhx74vr6 123 27 designed design VBN cord-258021-xhx74vr6 123 28 for for IN cord-258021-xhx74vr6 123 29 clinical clinical JJ cord-258021-xhx74vr6 123 30 samples sample NNS cord-258021-xhx74vr6 123 31 such such JJ cord-258021-xhx74vr6 123 32 as as IN cord-258021-xhx74vr6 123 33 sputum sputum NN cord-258021-xhx74vr6 123 34 , , , cord-258021-xhx74vr6 123 35 blood blood NN cord-258021-xhx74vr6 123 36 , , , cord-258021-xhx74vr6 123 37 or or CC cord-258021-xhx74vr6 123 38 urine urine NN cord-258021-xhx74vr6 123 39 _SP cord-258021-xhx74vr6 124 1 The the DT cord-258021-xhx74vr6 124 2 GeneXpert GeneXpert NNP cord-258021-xhx74vr6 124 3 system system NN cord-258021-xhx74vr6 124 4 has have VBZ cord-258021-xhx74vr6 124 5 already already RB cord-258021-xhx74vr6 124 6 been be VBN cord-258021-xhx74vr6 124 7 discussed discuss VBN cord-258021-xhx74vr6 124 8 , , , cord-258021-xhx74vr6 124 9 but but CC cord-258021-xhx74vr6 124 10 it -PRON- PRP cord-258021-xhx74vr6 124 11 is be VBZ cord-258021-xhx74vr6 124 12 worth worth JJ cord-258021-xhx74vr6 124 13 noting note VBG cord-258021-xhx74vr6 124 14 that that IN cord-258021-xhx74vr6 124 15 the the DT cord-258021-xhx74vr6 124 16 range range NN cord-258021-xhx74vr6 124 17 of of IN cord-258021-xhx74vr6 124 18 pathogen pathogen NN cord-258021-xhx74vr6 124 19 assays assay NNS cord-258021-xhx74vr6 124 20 is be VBZ cord-258021-xhx74vr6 124 21 steadily steadily RB cord-258021-xhx74vr6 124 22 increasing increase VBG cord-258021-xhx74vr6 124 23 and and CC cord-258021-xhx74vr6 124 24 now now RB cord-258021-xhx74vr6 124 25 includes include VBZ cord-258021-xhx74vr6 124 26 respiratory respiratory JJ cord-258021-xhx74vr6 124 27 syncytial syncytial JJ cord-258021-xhx74vr6 124 28 virus virus NN cord-258021-xhx74vr6 124 29 and and CC cord-258021-xhx74vr6 124 30 methicillinresistant methicillinresistant JJ cord-258021-xhx74vr6 124 31 Staphylococcus Staphylococcus NNP cord-258021-xhx74vr6 124 32 aureus aureus NN cord-258021-xhx74vr6 124 33 , , , cord-258021-xhx74vr6 124 34 which which WDT cord-258021-xhx74vr6 124 35 are be VBP cord-258021-xhx74vr6 124 36 clearly clearly RB cord-258021-xhx74vr6 124 37 relevant relevant JJ cord-258021-xhx74vr6 124 38 to to IN cord-258021-xhx74vr6 124 39 pneumonia pneumonia NN cord-258021-xhx74vr6 124 40 . . . cord-258021-xhx74vr6 125 1 FilmArray FilmArray NNP cord-258021-xhx74vr6 125 2 is be VBZ cord-258021-xhx74vr6 125 3 another another DT cord-258021-xhx74vr6 125 4 novel novel NN cord-258021-xhx74vr6 125 5 " " `` cord-258021-xhx74vr6 125 6 all all DT cord-258021-xhx74vr6 125 7 - - HYPH cord-258021-xhx74vr6 125 8 in in IN cord-258021-xhx74vr6 125 9 - - HYPH cord-258021-xhx74vr6 125 10 one one CD cord-258021-xhx74vr6 125 11 " " '' cord-258021-xhx74vr6 125 12 multiplex multiplex NN cord-258021-xhx74vr6 125 13 PCR PCR NNP cord-258021-xhx74vr6 125 14 platform platform NN cord-258021-xhx74vr6 125 15 with with IN cord-258021-xhx74vr6 125 16 minimal minimal JJ cord-258021-xhx74vr6 125 17 technical technical JJ cord-258021-xhx74vr6 125 18 expertise expertise NN cord-258021-xhx74vr6 125 19 required require VBN cord-258021-xhx74vr6 125 20 and and CC cord-258021-xhx74vr6 125 21 a a DT cord-258021-xhx74vr6 125 22 turnaround turnaround NN cord-258021-xhx74vr6 125 23 time time NN cord-258021-xhx74vr6 125 24 of of IN cord-258021-xhx74vr6 125 25 approximately approximately RB cord-258021-xhx74vr6 125 26 1 1 CD cord-258021-xhx74vr6 125 27 hour hour NN cord-258021-xhx74vr6 125 28 . . . cord-258021-xhx74vr6 126 1 Manual manual JJ cord-258021-xhx74vr6 126 2 handling handling NN cord-258021-xhx74vr6 126 3 is be VBZ cord-258021-xhx74vr6 126 4 very very RB cord-258021-xhx74vr6 126 5 limited limited JJ cord-258021-xhx74vr6 126 6 , , , cord-258021-xhx74vr6 126 7 as as IN cord-258021-xhx74vr6 126 8 with with IN cord-258021-xhx74vr6 126 9 GeneXpert GeneXpert NNP cord-258021-xhx74vr6 126 10 , , , cord-258021-xhx74vr6 126 11 and and CC cord-258021-xhx74vr6 126 12 a a DT cord-258021-xhx74vr6 126 13 variety variety NN cord-258021-xhx74vr6 126 14 of of IN cord-258021-xhx74vr6 126 15 panels panel NNS cord-258021-xhx74vr6 126 16 are be VBP cord-258021-xhx74vr6 126 17 available available JJ cord-258021-xhx74vr6 126 18 . . . cord-258021-xhx74vr6 127 1 The the DT cord-258021-xhx74vr6 127 2 commercially commercially RB cord-258021-xhx74vr6 127 3 available available JJ cord-258021-xhx74vr6 127 4 respiratory respiratory JJ cord-258021-xhx74vr6 127 5 panel panel NN cord-258021-xhx74vr6 127 6 detects detect VBZ cord-258021-xhx74vr6 127 7 17 17 CD cord-258021-xhx74vr6 127 8 viral viral JJ cord-258021-xhx74vr6 127 9 and and CC cord-258021-xhx74vr6 127 10 3 3 CD cord-258021-xhx74vr6 127 11 bacterial bacterial JJ cord-258021-xhx74vr6 127 12 pathogens pathogen NNS cord-258021-xhx74vr6 127 13 . . . cord-258021-xhx74vr6 128 1 The the DT cord-258021-xhx74vr6 128 2 performance performance NN cord-258021-xhx74vr6 128 3 of of IN cord-258021-xhx74vr6 128 4 the the DT cord-258021-xhx74vr6 128 5 respiratory respiratory JJ cord-258021-xhx74vr6 128 6 panel panel NN cord-258021-xhx74vr6 128 7 has have VBZ cord-258021-xhx74vr6 128 8 been be VBN cord-258021-xhx74vr6 128 9 compared compare VBN cord-258021-xhx74vr6 128 10 with with IN cord-258021-xhx74vr6 128 11 " " `` cord-258021-xhx74vr6 128 12 in in IN cord-258021-xhx74vr6 128 13 - - HYPH cord-258021-xhx74vr6 128 14 house house NN cord-258021-xhx74vr6 128 15 " " '' cord-258021-xhx74vr6 128 16 PCR PCR NNP cord-258021-xhx74vr6 128 17 tests test NNS cord-258021-xhx74vr6 128 18 with with IN cord-258021-xhx74vr6 128 19 favorable favorable JJ cord-258021-xhx74vr6 128 20 results result NNS cord-258021-xhx74vr6 129 1 67,68 67,68 CD cord-258021-xhx74vr6 129 2 and and CC cord-258021-xhx74vr6 129 3 the the DT cord-258021-xhx74vr6 129 4 system system NN cord-258021-xhx74vr6 129 5 seems seem VBZ cord-258021-xhx74vr6 129 6 to to TO cord-258021-xhx74vr6 129 7 be be VB cord-258021-xhx74vr6 129 8 robust robust JJ cord-258021-xhx74vr6 129 9 enough enough RB cord-258021-xhx74vr6 129 10 to to TO cord-258021-xhx74vr6 129 11 be be VB cord-258021-xhx74vr6 129 12 useful useful JJ cord-258021-xhx74vr6 129 13 in in IN cord-258021-xhx74vr6 129 14 routine routine JJ cord-258021-xhx74vr6 129 15 clinical clinical JJ cord-258021-xhx74vr6 129 16 practice practice NN cord-258021-xhx74vr6 129 17 . . . cord-258021-xhx74vr6 130 1 69 69 CD cord-258021-xhx74vr6 131 1 , , , cord-258021-xhx74vr6 131 2 70 70 CD cord-258021-xhx74vr6 131 3 Curetis Curetis NNP cord-258021-xhx74vr6 131 4 Unyvero Unyvero NNP cord-258021-xhx74vr6 132 1 The the DT cord-258021-xhx74vr6 132 2 Curetis Curetis NNP cord-258021-xhx74vr6 132 3 Unyvero Unyvero NNP cord-258021-xhx74vr6 132 4 P50 P50 NNP cord-258021-xhx74vr6 132 5 pneumonia pneumonia NN cord-258021-xhx74vr6 132 6 cartridge cartridge NN cord-258021-xhx74vr6 132 7 can can MD cord-258021-xhx74vr6 132 8 detect detect VB cord-258021-xhx74vr6 132 9 17 17 CD cord-258021-xhx74vr6 132 10 bacterial bacterial JJ cord-258021-xhx74vr6 132 11 and and CC cord-258021-xhx74vr6 132 12 fungal fungal JJ cord-258021-xhx74vr6 132 13 pathogens pathogen NNS cord-258021-xhx74vr6 132 14 and and CC cord-258021-xhx74vr6 132 15 22 22 CD cord-258021-xhx74vr6 132 16 antibiotic antibiotic JJ cord-258021-xhx74vr6 132 17 resistance resistance NN cord-258021-xhx74vr6 132 18 markers marker NNS cord-258021-xhx74vr6 132 19 from from IN cord-258021-xhx74vr6 132 20 respiratory respiratory JJ cord-258021-xhx74vr6 132 21 samples sample NNS cord-258021-xhx74vr6 132 22 in in IN cord-258021-xhx74vr6 132 23 a a DT cord-258021-xhx74vr6 132 24 single single JJ cord-258021-xhx74vr6 132 25 run run NN cord-258021-xhx74vr6 132 26 in in IN cord-258021-xhx74vr6 132 27 approximately approximately RB cord-258021-xhx74vr6 132 28 4 4 CD cord-258021-xhx74vr6 132 29 hours hour NNS cord-258021-xhx74vr6 132 30 . . . cord-258021-xhx74vr6 133 1 71 71 CD cord-258021-xhx74vr6 134 1 The the DT cord-258021-xhx74vr6 134 2 panel panel NN cord-258021-xhx74vr6 134 3 includes include VBZ cord-258021-xhx74vr6 134 4 L L NNP cord-258021-xhx74vr6 134 5 pneumophila pneumophila NN cord-258021-xhx74vr6 134 6 and and CC cord-258021-xhx74vr6 134 7 M M NNP cord-258021-xhx74vr6 134 8 pneumoniae pneumoniae NN cord-258021-xhx74vr6 134 9 , , , cord-258021-xhx74vr6 134 10 but but CC cord-258021-xhx74vr6 134 11 specific specific JJ cord-258021-xhx74vr6 134 12 performance performance NN cord-258021-xhx74vr6 134 13 data datum NNS cord-258021-xhx74vr6 134 14 on on IN cord-258021-xhx74vr6 134 15 these these DT cord-258021-xhx74vr6 134 16 pathogens pathogen NNS cord-258021-xhx74vr6 134 17 from from IN cord-258021-xhx74vr6 134 18 clinical clinical JJ cord-258021-xhx74vr6 134 19 studies study NNS cord-258021-xhx74vr6 134 20 has have VBZ cord-258021-xhx74vr6 134 21 not not RB cord-258021-xhx74vr6 134 22 been be VBN cord-258021-xhx74vr6 134 23 reported report VBN cord-258021-xhx74vr6 134 24 . . . cord-258021-xhx74vr6 135 1 A a DT cord-258021-xhx74vr6 135 2 preliminary preliminary JJ cord-258021-xhx74vr6 135 3 study study NN cord-258021-xhx74vr6 135 4 in in IN cord-258021-xhx74vr6 135 5 critically critically RB cord-258021-xhx74vr6 135 6 ill ill JJ cord-258021-xhx74vr6 135 7 patients patient NNS cord-258021-xhx74vr6 135 8 found find VBD cord-258021-xhx74vr6 135 9 the the DT cord-258021-xhx74vr6 135 10 performance performance NN cord-258021-xhx74vr6 135 11 of of IN cord-258021-xhx74vr6 135 12 the the DT cord-258021-xhx74vr6 135 13 Curetis Curetis NNP cord-258021-xhx74vr6 135 14 Unyvero Unyvero NNP cord-258021-xhx74vr6 135 15 to to TO cord-258021-xhx74vr6 135 16 be be VB cord-258021-xhx74vr6 135 17 questionable questionable JJ cord-258021-xhx74vr6 135 18 , , , cord-258021-xhx74vr6 135 19 but but CC cord-258021-xhx74vr6 135 20 noted note VBD cord-258021-xhx74vr6 135 21 the the DT cord-258021-xhx74vr6 135 22 system system NN cord-258021-xhx74vr6 135 23 was be VBD cord-258021-xhx74vr6 135 24 still still RB cord-258021-xhx74vr6 135 25 under under IN cord-258021-xhx74vr6 135 26 development development NN cord-258021-xhx74vr6 135 27 . . . cord-258021-xhx74vr6 136 1 72 72 CD cord-258021-xhx74vr6 136 2 _SP cord-258021-xhx74vr6 136 3 Mass Mass NNP cord-258021-xhx74vr6 136 4 spectrometry spectrometry NN cord-258021-xhx74vr6 136 5 has have VBZ cord-258021-xhx74vr6 136 6 been be VBN cord-258021-xhx74vr6 136 7 available available JJ cord-258021-xhx74vr6 136 8 for for IN cord-258021-xhx74vr6 136 9 decades decade NNS cord-258021-xhx74vr6 136 10 , , , cord-258021-xhx74vr6 136 11 but but CC cord-258021-xhx74vr6 136 12 improvements improvement NNS cord-258021-xhx74vr6 136 13 in in IN cord-258021-xhx74vr6 136 14 size size NN cord-258021-xhx74vr6 136 15 , , , cord-258021-xhx74vr6 136 16 speed speed NN cord-258021-xhx74vr6 136 17 , , , cord-258021-xhx74vr6 136 18 and and CC cord-258021-xhx74vr6 136 19 cost cost NN cord-258021-xhx74vr6 136 20 have have VBP cord-258021-xhx74vr6 136 21 brought bring VBN cord-258021-xhx74vr6 136 22 this this DT cord-258021-xhx74vr6 136 23 technology technology NN cord-258021-xhx74vr6 136 24 to to IN cord-258021-xhx74vr6 136 25 a a DT cord-258021-xhx74vr6 136 26 point point NN cord-258021-xhx74vr6 136 27 where where WRB cord-258021-xhx74vr6 136 28 it -PRON- PRP cord-258021-xhx74vr6 136 29 can can MD cord-258021-xhx74vr6 136 30 be be VB cord-258021-xhx74vr6 136 31 used use VBN cord-258021-xhx74vr6 136 32 for for IN cord-258021-xhx74vr6 136 33 both both DT cord-258021-xhx74vr6 136 34 broadrange broadrange NN cord-258021-xhx74vr6 136 35 and and CC cord-258021-xhx74vr6 136 36 target target NN cord-258021-xhx74vr6 136 37 - - HYPH cord-258021-xhx74vr6 136 38 specific specific JJ cord-258021-xhx74vr6 136 39 identification identification NN cord-258021-xhx74vr6 136 40 of of IN cord-258021-xhx74vr6 136 41 pathogens pathogen NNS cord-258021-xhx74vr6 136 42 . . . cord-258021-xhx74vr6 137 1 PCRelectrospray pcrelectrospray NN cord-258021-xhx74vr6 137 2 ionization ionization NN cord-258021-xhx74vr6 137 3 mass mass NN cord-258021-xhx74vr6 137 4 spectrometry spectrometry NN cord-258021-xhx74vr6 137 5 holds hold VBZ cord-258021-xhx74vr6 137 6 particular particular JJ cord-258021-xhx74vr6 137 7 promise promise NN cord-258021-xhx74vr6 137 8 given give VBN cord-258021-xhx74vr6 137 9 that that IN cord-258021-xhx74vr6 137 10 it -PRON- PRP cord-258021-xhx74vr6 137 11 can can MD cord-258021-xhx74vr6 137 12 identify identify VB cord-258021-xhx74vr6 137 13 minute minute NN cord-258021-xhx74vr6 137 14 quantities quantity NNS cord-258021-xhx74vr6 137 15 and and CC cord-258021-xhx74vr6 137 16 mixtures mixture NNS cord-258021-xhx74vr6 137 17 of of IN cord-258021-xhx74vr6 137 18 nucleic nucleic JJ cord-258021-xhx74vr6 137 19 acids acid NNS cord-258021-xhx74vr6 137 20 from from IN cord-258021-xhx74vr6 137 21 microbial microbial JJ cord-258021-xhx74vr6 137 22 isolates isolate NNS cord-258021-xhx74vr6 137 23 or or CC cord-258021-xhx74vr6 137 24 directly directly RB cord-258021-xhx74vr6 137 25 from from IN cord-258021-xhx74vr6 137 26 clinical clinical JJ cord-258021-xhx74vr6 137 27 specimens specimen NNS cord-258021-xhx74vr6 137 28 . . . cord-258021-xhx74vr6 138 1 The the DT cord-258021-xhx74vr6 138 2 performance performance NN cord-258021-xhx74vr6 138 3 of of IN cord-258021-xhx74vr6 138 4 PCR pcr NN cord-258021-xhx74vr6 138 5 - - HYPH cord-258021-xhx74vr6 138 6 electrospray electrospray JJ cord-258021-xhx74vr6 138 7 ionization ionization NN cord-258021-xhx74vr6 138 8 mass mass NN cord-258021-xhx74vr6 138 9 spectrometry spectrometry NN cord-258021-xhx74vr6 138 10 for for IN cord-258021-xhx74vr6 138 11 detecting detect VBG cord-258021-xhx74vr6 138 12 influenza influenza NN cord-258021-xhx74vr6 138 13 in in IN cord-258021-xhx74vr6 138 14 clinical clinical JJ cord-258021-xhx74vr6 138 15 samples sample NNS cord-258021-xhx74vr6 138 16 seems seem VBZ cord-258021-xhx74vr6 138 17 at at IN cord-258021-xhx74vr6 138 18 least least JJS cord-258021-xhx74vr6 138 19 as as RB cord-258021-xhx74vr6 138 20 good good JJ cord-258021-xhx74vr6 138 21 as as IN cord-258021-xhx74vr6 138 22 conventional conventional JJ cord-258021-xhx74vr6 138 23 PCR PCR NNP cord-258021-xhx74vr6 138 24 assays assay NNS cord-258021-xhx74vr6 138 25 . . . cord-258021-xhx74vr6 139 1 73 73 CD cord-258021-xhx74vr6 140 1 A a DT cord-258021-xhx74vr6 140 2 single single JJ cord-258021-xhx74vr6 140 3 study study NN cord-258021-xhx74vr6 140 4 from from IN cord-258021-xhx74vr6 140 5 Taiwan Taiwan NNP cord-258021-xhx74vr6 140 6 indicates indicate VBZ cord-258021-xhx74vr6 140 7 that that IN cord-258021-xhx74vr6 140 8 PCR pcr NN cord-258021-xhx74vr6 140 9 - - HYPH cord-258021-xhx74vr6 140 10 electrospray electrospray JJ cord-258021-xhx74vr6 140 11 ionization ionization NN cord-258021-xhx74vr6 140 12 mass mass NN cord-258021-xhx74vr6 140 13 spectrometry spectrometry NN cord-258021-xhx74vr6 140 14 has have VBZ cord-258021-xhx74vr6 140 15 promise promise NN cord-258021-xhx74vr6 140 16 for for IN cord-258021-xhx74vr6 140 17 the the DT cord-258021-xhx74vr6 140 18 detection detection NN cord-258021-xhx74vr6 140 19 of of IN cord-258021-xhx74vr6 140 20 multiple multiple JJ cord-258021-xhx74vr6 140 21 viruses virus NNS cord-258021-xhx74vr6 140 22 in in IN cord-258021-xhx74vr6 140 23 the the DT cord-258021-xhx74vr6 140 24 setting setting NN cord-258021-xhx74vr6 140 25 of of IN cord-258021-xhx74vr6 140 26 respiratory respiratory JJ cord-258021-xhx74vr6 140 27 tract tract NN cord-258021-xhx74vr6 140 28 infection infection NN cord-258021-xhx74vr6 140 29 but but CC cord-258021-xhx74vr6 140 30 this this DT cord-258021-xhx74vr6 140 31 was be VBD cord-258021-xhx74vr6 140 32 done do VBN cord-258021-xhx74vr6 140 33 retrospectively retrospectively RB cord-258021-xhx74vr6 140 34 rather rather RB cord-258021-xhx74vr6 140 35 than than IN cord-258021-xhx74vr6 140 36 in in IN cord-258021-xhx74vr6 140 37 real real JJ cord-258021-xhx74vr6 140 38 time time NN cord-258021-xhx74vr6 140 39 . . . cord-258021-xhx74vr6 141 1 74 74 CD cord-258021-xhx74vr6 142 1 A a DT cord-258021-xhx74vr6 142 2 different different JJ cord-258021-xhx74vr6 142 3 use use NN cord-258021-xhx74vr6 142 4 of of IN cord-258021-xhx74vr6 142 5 mass mass NN cord-258021-xhx74vr6 142 6 spectrometry spectrometry NN cord-258021-xhx74vr6 142 7 , , , cord-258021-xhx74vr6 142 8 matrixassisted matrixassiste VBN cord-258021-xhx74vr6 142 9 laser laser NN cord-258021-xhx74vr6 142 10 desorption desorption NN cord-258021-xhx74vr6 142 11 / / SYM cord-258021-xhx74vr6 142 12 ionization ionization NN cord-258021-xhx74vr6 142 13 time time NN cord-258021-xhx74vr6 142 14 of of IN cord-258021-xhx74vr6 142 15 flight flight NN cord-258021-xhx74vr6 142 16 mass mass NN cord-258021-xhx74vr6 142 17 spectrometry spectrometry NN cord-258021-xhx74vr6 142 18 ( ( -LRB- cord-258021-xhx74vr6 142 19 MALDI MALDI NNP cord-258021-xhx74vr6 142 20 - - HYPH cord-258021-xhx74vr6 142 21 TOF TOF NNP cord-258021-xhx74vr6 142 22 - - HYPH cord-258021-xhx74vr6 142 23 MS MS NNP cord-258021-xhx74vr6 142 24 ) ) -RRB- cord-258021-xhx74vr6 142 25 is be VBZ cord-258021-xhx74vr6 142 26 also also RB cord-258021-xhx74vr6 142 27 a a DT cord-258021-xhx74vr6 142 28 protein protein NN cord-258021-xhx74vr6 142 29 / / SYM cord-258021-xhx74vr6 142 30 peptide peptide NN cord-258021-xhx74vr6 142 31 diagnostic diagnostic JJ cord-258021-xhx74vr6 142 32 tool tool NN cord-258021-xhx74vr6 142 33 that that WDT cord-258021-xhx74vr6 142 34 has have VBZ cord-258021-xhx74vr6 142 35 been be VBN cord-258021-xhx74vr6 142 36 shown show VBN cord-258021-xhx74vr6 142 37 to to TO cord-258021-xhx74vr6 142 38 have have VB cord-258021-xhx74vr6 142 39 usefulness usefulness NN cord-258021-xhx74vr6 142 40 in in IN cord-258021-xhx74vr6 142 41 identifying identify VBG cord-258021-xhx74vr6 142 42 microorganisms microorganism NNS cord-258021-xhx74vr6 142 43 at at IN cord-258021-xhx74vr6 142 44 a a DT cord-258021-xhx74vr6 142 45 species species NN cord-258021-xhx74vr6 142 46 level level NN cord-258021-xhx74vr6 142 47 . . . cord-258021-xhx74vr6 143 1 MALDI MALDI NNP cord-258021-xhx74vr6 143 2 - - HYPH cord-258021-xhx74vr6 143 3 TOF TOF NNP cord-258021-xhx74vr6 143 4 - - HYPH cord-258021-xhx74vr6 143 5 MS MS NNP cord-258021-xhx74vr6 143 6 has have VBZ cord-258021-xhx74vr6 143 7 been be VBN cord-258021-xhx74vr6 143 8 assessed assess VBN cord-258021-xhx74vr6 143 9 predominantly predominantly RB cord-258021-xhx74vr6 143 10 as as IN cord-258021-xhx74vr6 143 11 a a DT cord-258021-xhx74vr6 143 12 means means NN cord-258021-xhx74vr6 143 13 of of IN cord-258021-xhx74vr6 143 14 rapidly rapidly RB cord-258021-xhx74vr6 143 15 identifying identify VBG cord-258021-xhx74vr6 143 16 the the DT cord-258021-xhx74vr6 143 17 identity identity NN cord-258021-xhx74vr6 143 18 of of IN cord-258021-xhx74vr6 143 19 both both DT cord-258021-xhx74vr6 143 20 bacteria bacteria NNS cord-258021-xhx74vr6 143 21 and and CC cord-258021-xhx74vr6 143 22 their -PRON- PRP$ cord-258021-xhx74vr6 143 23 bacterial bacterial JJ cord-258021-xhx74vr6 143 24 products product NNS cord-258021-xhx74vr6 143 25 from from IN cord-258021-xhx74vr6 143 26 positive positive JJ cord-258021-xhx74vr6 143 27 blood blood NN cord-258021-xhx74vr6 143 28 cultures culture NNS cord-258021-xhx74vr6 143 29 , , , cord-258021-xhx74vr6 143 30 up up IN cord-258021-xhx74vr6 143 31 to to TO cord-258021-xhx74vr6 143 32 24 24 CD cord-258021-xhx74vr6 143 33 hours hour NNS cord-258021-xhx74vr6 143 34 faster fast RBR cord-258021-xhx74vr6 143 35 than than IN cord-258021-xhx74vr6 143 36 conventional conventional JJ cord-258021-xhx74vr6 143 37 methods method NNS cord-258021-xhx74vr6 143 38 . . . cord-258021-xhx74vr6 144 1 A a DT cord-258021-xhx74vr6 144 2 comparison comparison NN cord-258021-xhx74vr6 144 3 of of IN cord-258021-xhx74vr6 144 4 the the DT cord-258021-xhx74vr6 144 5 diagnostic diagnostic JJ cord-258021-xhx74vr6 144 6 accuracy accuracy NN cord-258021-xhx74vr6 144 7 of of IN cord-258021-xhx74vr6 144 8 MALDI MALDI NNP cord-258021-xhx74vr6 144 9 - - HYPH cord-258021-xhx74vr6 144 10 TOF TOF NNP cord-258021-xhx74vr6 144 11 - - HYPH cord-258021-xhx74vr6 144 12 MS MS NNP cord-258021-xhx74vr6 144 13 with with IN cord-258021-xhx74vr6 144 14 liquid liquid JJ cord-258021-xhx74vr6 144 15 chromatography chromatography NN cord-258021-xhx74vr6 144 16 MS MS NNP cord-258021-xhx74vr6 144 17 for for IN cord-258021-xhx74vr6 144 18 influenza influenza NN cord-258021-xhx74vr6 144 19 A A NNP cord-258021-xhx74vr6 144 20 , , , cord-258021-xhx74vr6 144 21 metapneumovirus metapneumovirus NN cord-258021-xhx74vr6 144 22 , , , cord-258021-xhx74vr6 144 23 and and CC cord-258021-xhx74vr6 144 24 respiratory respiratory JJ cord-258021-xhx74vr6 144 25 syncytial syncytial JJ cord-258021-xhx74vr6 144 26 virus virus NN cord-258021-xhx74vr6 144 27 suggested suggest VBD cord-258021-xhx74vr6 144 28 the the DT cord-258021-xhx74vr6 144 29 latter latter JJ cord-258021-xhx74vr6 144 30 may may MD cord-258021-xhx74vr6 144 31 be be VB cord-258021-xhx74vr6 144 32 superior superior JJ cord-258021-xhx74vr6 144 33 . . . cord-258021-xhx74vr6 145 1 75 75 CD cord-258021-xhx74vr6 146 1 A a DT cord-258021-xhx74vr6 146 2 potential potential JJ cord-258021-xhx74vr6 146 3 and and CC cord-258021-xhx74vr6 146 4 significant significant JJ cord-258021-xhx74vr6 146 5 limitation limitation NN cord-258021-xhx74vr6 146 6 of of IN cord-258021-xhx74vr6 146 7 current current JJ cord-258021-xhx74vr6 146 8 MALDI MALDI NNP cord-258021-xhx74vr6 146 9 - - HYPH cord-258021-xhx74vr6 146 10 TOF TOF NNP cord-258021-xhx74vr6 146 11 - - HYPH cord-258021-xhx74vr6 146 12 MS MS NNP cord-258021-xhx74vr6 146 13 is be VBZ cord-258021-xhx74vr6 146 14 that that IN cord-258021-xhx74vr6 146 15 when when WRB cord-258021-xhx74vr6 146 16 a a DT cord-258021-xhx74vr6 146 17 large large JJ cord-258021-xhx74vr6 146 18 mixture mixture NN cord-258021-xhx74vr6 146 19 of of IN cord-258021-xhx74vr6 146 20 bacteria bacteria NNS cord-258021-xhx74vr6 146 21 are be VBP cord-258021-xhx74vr6 146 22 present present JJ cord-258021-xhx74vr6 146 23 , , , cord-258021-xhx74vr6 146 24 as as IN cord-258021-xhx74vr6 146 25 occurs occur VBZ cord-258021-xhx74vr6 146 26 more more RBR cord-258021-xhx74vr6 146 27 commonly commonly RB cord-258021-xhx74vr6 146 28 in in IN cord-258021-xhx74vr6 146 29 hospital hospital NN cord-258021-xhx74vr6 146 30 - - HYPH cord-258021-xhx74vr6 146 31 acquired acquire VBN cord-258021-xhx74vr6 146 32 pneumonia pneumonia NN cord-258021-xhx74vr6 146 33 and and CC cord-258021-xhx74vr6 146 34 ventilator ventilator NN cord-258021-xhx74vr6 146 35 - - HYPH cord-258021-xhx74vr6 146 36 acquired acquire VBN cord-258021-xhx74vr6 146 37 pneumonia pneumonia NN cord-258021-xhx74vr6 146 38 , , , cord-258021-xhx74vr6 146 39 the the DT cord-258021-xhx74vr6 146 40 sensitivity sensitivity NN cord-258021-xhx74vr6 146 41 and and CC cord-258021-xhx74vr6 146 42 specificity specificity NN cord-258021-xhx74vr6 146 43 become become VBN cord-258021-xhx74vr6 146 44 suboptimal suboptimal JJ cord-258021-xhx74vr6 146 45 . . . cord-258021-xhx74vr6 147 1 76 76 CD cord-258021-xhx74vr6 148 1 Next next JJ cord-258021-xhx74vr6 148 2 - - HYPH cord-258021-xhx74vr6 148 3 generation generation NN cord-258021-xhx74vr6 148 4 sequencing sequencing NN cord-258021-xhx74vr6 148 5 , , , cord-258021-xhx74vr6 148 6 also also RB cord-258021-xhx74vr6 148 7 known know VBN cord-258021-xhx74vr6 148 8 as as IN cord-258021-xhx74vr6 148 9 highthroughput highthroughput NN cord-258021-xhx74vr6 148 10 sequencing sequencing NN cord-258021-xhx74vr6 148 11 , , , cord-258021-xhx74vr6 148 12 is be VBZ cord-258021-xhx74vr6 148 13 a a DT cord-258021-xhx74vr6 148 14 generic generic JJ cord-258021-xhx74vr6 148 15 term term NN cord-258021-xhx74vr6 148 16 used use VBN cord-258021-xhx74vr6 148 17 to to TO cord-258021-xhx74vr6 148 18 describe describe VB cord-258021-xhx74vr6 148 19 a a DT cord-258021-xhx74vr6 148 20 group group NN cord-258021-xhx74vr6 148 21 of of IN cord-258021-xhx74vr6 148 22 different different JJ cord-258021-xhx74vr6 148 23 modern modern JJ cord-258021-xhx74vr6 148 24 sequencing sequencing NN cord-258021-xhx74vr6 148 25 technologies technology NNS cord-258021-xhx74vr6 148 26 including include VBG cord-258021-xhx74vr6 148 27 Illumina Illumina NNP cord-258021-xhx74vr6 148 28 ( ( -LRB- cord-258021-xhx74vr6 148 29 Solexa Solexa NNP cord-258021-xhx74vr6 148 30 , , , cord-258021-xhx74vr6 148 31 San San NNP cord-258021-xhx74vr6 148 32 Diego Diego NNP cord-258021-xhx74vr6 148 33 , , , cord-258021-xhx74vr6 148 34 CA CA NNP cord-258021-xhx74vr6 148 35 ) ) -RRB- cord-258021-xhx74vr6 148 36 sequencing sequencing NN cord-258021-xhx74vr6 148 37 , , , cord-258021-xhx74vr6 148 38 Roche Roche NNP cord-258021-xhx74vr6 148 39 454 454 CD cord-258021-xhx74vr6 148 40 sequencing sequencing NN cord-258021-xhx74vr6 148 41 , , , cord-258021-xhx74vr6 148 42 Ion ion NN cord-258021-xhx74vr6 148 43 torrent torrent NN cord-258021-xhx74vr6 148 44 : : : cord-258021-xhx74vr6 149 1 Proton proton NN cord-258021-xhx74vr6 149 2 / / SYM cord-258021-xhx74vr6 149 3 PGM PGM NNP cord-258021-xhx74vr6 149 4 Sequencing Sequencing NNP cord-258021-xhx74vr6 149 5 ( ( -LRB- cord-258021-xhx74vr6 149 6 Thermo Thermo NNP cord-258021-xhx74vr6 149 7 - - HYPH cord-258021-xhx74vr6 149 8 Fisher Fisher NNP cord-258021-xhx74vr6 149 9 Scientific Scientific NNP cord-258021-xhx74vr6 149 10 , , , cord-258021-xhx74vr6 149 11 Waltham Waltham NNP cord-258021-xhx74vr6 149 12 , , , cord-258021-xhx74vr6 149 13 MA MA NNP cord-258021-xhx74vr6 149 14 ) ) -RRB- cord-258021-xhx74vr6 149 15 , , , cord-258021-xhx74vr6 149 16 and and CC cord-258021-xhx74vr6 149 17 SOLiD solid NN cord-258021-xhx74vr6 149 18 sequencing sequencing NN cord-258021-xhx74vr6 149 19 ( ( -LRB- cord-258021-xhx74vr6 149 20 ThermoFisher ThermoFisher NNP cord-258021-xhx74vr6 149 21 Scientific Scientific NNP cord-258021-xhx74vr6 149 22 , , , cord-258021-xhx74vr6 149 23 Waltham Waltham NNP cord-258021-xhx74vr6 149 24 , , , cord-258021-xhx74vr6 149 25 MA MA NNP cord-258021-xhx74vr6 149 26 ) ) -RRB- cord-258021-xhx74vr6 149 27 . . . cord-258021-xhx74vr6 150 1 These these DT cord-258021-xhx74vr6 150 2 recent recent JJ cord-258021-xhx74vr6 150 3 technologies technology NNS cord-258021-xhx74vr6 150 4 allow allow VBP cord-258021-xhx74vr6 150 5 sequencing sequencing NN cord-258021-xhx74vr6 150 6 of of IN cord-258021-xhx74vr6 150 7 DNA DNA NNP cord-258021-xhx74vr6 150 8 and and CC cord-258021-xhx74vr6 150 9 RNA RNA NNP cord-258021-xhx74vr6 150 10 much much RB cord-258021-xhx74vr6 150 11 more more RBR cord-258021-xhx74vr6 150 12 quickly quickly RB cord-258021-xhx74vr6 150 13 and and CC cord-258021-xhx74vr6 150 14 cheaply cheaply RB cord-258021-xhx74vr6 150 15 than than IN cord-258021-xhx74vr6 150 16 the the DT cord-258021-xhx74vr6 150 17 previously previously RB cord-258021-xhx74vr6 150 18 used use VBN cord-258021-xhx74vr6 150 19 Sanger Sanger NNP cord-258021-xhx74vr6 150 20 sequencing sequencing NN cord-258021-xhx74vr6 150 21 ( ( -LRB- cord-258021-xhx74vr6 150 22 ThermoFisher ThermoFisher NNP cord-258021-xhx74vr6 150 23 Scientific Scientific NNP cord-258021-xhx74vr6 150 24 , , , cord-258021-xhx74vr6 150 25 Waltham Waltham NNP cord-258021-xhx74vr6 150 26 , , , cord-258021-xhx74vr6 150 27 MA MA NNP cord-258021-xhx74vr6 150 28 ) ) -RRB- cord-258021-xhx74vr6 150 29 . . . cord-258021-xhx74vr6 151 1 To to IN cord-258021-xhx74vr6 151 2 date date NN cord-258021-xhx74vr6 151 3 , , , cord-258021-xhx74vr6 151 4 there there EX cord-258021-xhx74vr6 151 5 are be VBP cord-258021-xhx74vr6 151 6 few few JJ cord-258021-xhx74vr6 151 7 data datum NNS cord-258021-xhx74vr6 151 8 on on IN cord-258021-xhx74vr6 151 9 the the DT cord-258021-xhx74vr6 151 10 applicability applicability NN cord-258021-xhx74vr6 151 11 of of IN cord-258021-xhx74vr6 151 12 nextgeneration nextgeneration NN cord-258021-xhx74vr6 151 13 sequencing sequence VBG cord-258021-xhx74vr6 151 14 to to IN cord-258021-xhx74vr6 151 15 immediate immediate JJ cord-258021-xhx74vr6 151 16 clinical clinical JJ cord-258021-xhx74vr6 151 17 care care NN cord-258021-xhx74vr6 151 18 , , , cord-258021-xhx74vr6 151 19 but but CC cord-258021-xhx74vr6 151 20 it -PRON- PRP cord-258021-xhx74vr6 151 21 has have VBZ cord-258021-xhx74vr6 151 22 been be VBN cord-258021-xhx74vr6 151 23 particularly particularly RB cord-258021-xhx74vr6 151 24 useful useful JJ cord-258021-xhx74vr6 151 25 in in IN cord-258021-xhx74vr6 151 26 diagnosing diagnose VBG cord-258021-xhx74vr6 151 27 new new JJ cord-258021-xhx74vr6 151 28 and/or and/or CC cord-258021-xhx74vr6 151 29 novel novel JJ cord-258021-xhx74vr6 151 30 pathogens pathogen NNS cord-258021-xhx74vr6 151 31 for for IN cord-258021-xhx74vr6 151 32 which which WDT cord-258021-xhx74vr6 151 33 there there EX cord-258021-xhx74vr6 151 34 are be VBP cord-258021-xhx74vr6 151 35 no no DT cord-258021-xhx74vr6 151 36 available available JJ cord-258021-xhx74vr6 151 37 assays assay NNS cord-258021-xhx74vr6 151 38 . . . cord-258021-xhx74vr6 152 1 As as IN cord-258021-xhx74vr6 152 2 technology technology NN cord-258021-xhx74vr6 152 3 has have VBZ cord-258021-xhx74vr6 152 4 improved improve VBN cord-258021-xhx74vr6 152 5 , , , cord-258021-xhx74vr6 152 6 we -PRON- PRP cord-258021-xhx74vr6 152 7 have have VBP cord-258021-xhx74vr6 152 8 moved move VBN cord-258021-xhx74vr6 152 9 from from IN cord-258021-xhx74vr6 152 10 relying rely VBG cord-258021-xhx74vr6 152 11 on on IN cord-258021-xhx74vr6 152 12 serologic serologic JJ cord-258021-xhx74vr6 152 13 tests test NNS cord-258021-xhx74vr6 152 14 to to TO cord-258021-xhx74vr6 152 15 diagnose diagnose VB cord-258021-xhx74vr6 152 16 atypical atypical JJ cord-258021-xhx74vr6 152 17 and and CC cord-258021-xhx74vr6 152 18 viral viral JJ cord-258021-xhx74vr6 152 19 pathogens pathogen NNS cord-258021-xhx74vr6 152 20 to to TO cord-258021-xhx74vr6 152 21 direct direct JJ cord-258021-xhx74vr6 152 22 detection detection NN cord-258021-xhx74vr6 152 23 of of IN cord-258021-xhx74vr6 152 24 these these DT cord-258021-xhx74vr6 152 25 pathogens pathogen NNS cord-258021-xhx74vr6 152 26 in in IN cord-258021-xhx74vr6 152 27 clinical clinical JJ cord-258021-xhx74vr6 152 28 specimens specimen NNS cord-258021-xhx74vr6 152 29 . . . cord-258021-xhx74vr6 153 1 Starting start VBG cord-258021-xhx74vr6 153 2 from from IN cord-258021-xhx74vr6 153 3 a a DT cord-258021-xhx74vr6 153 4 base base NN cord-258021-xhx74vr6 153 5 of of IN cord-258021-xhx74vr6 153 6 homegrown homegrown JJ cord-258021-xhx74vr6 153 7 PCR PCR NNP cord-258021-xhx74vr6 153 8 assays assay NNS cord-258021-xhx74vr6 153 9 , , , cord-258021-xhx74vr6 153 10 an an DT cord-258021-xhx74vr6 153 11 increasing increase VBG cord-258021-xhx74vr6 153 12 array array NN cord-258021-xhx74vr6 153 13 of of IN cord-258021-xhx74vr6 153 14 commercial commercial JJ cord-258021-xhx74vr6 153 15 assays assay NNS cord-258021-xhx74vr6 153 16 have have VBP cord-258021-xhx74vr6 153 17 appeared appear VBN cord-258021-xhx74vr6 153 18 , , , cord-258021-xhx74vr6 153 19 first first RB cord-258021-xhx74vr6 153 20 as as IN cord-258021-xhx74vr6 153 21 single single JJ cord-258021-xhx74vr6 153 22 pathogen pathogen NN cord-258021-xhx74vr6 153 23 assays assay NNS cord-258021-xhx74vr6 153 24 , , , cord-258021-xhx74vr6 153 25 and and CC cord-258021-xhx74vr6 153 26 increasingly increasingly RB cord-258021-xhx74vr6 153 27 as as IN cord-258021-xhx74vr6 153 28 multiplexed multiplexed JJ cord-258021-xhx74vr6 153 29 tests test NNS cord-258021-xhx74vr6 153 30 . . . cord-258021-xhx74vr6 154 1 Increasing increase VBG cord-258021-xhx74vr6 154 2 focus focus NN cord-258021-xhx74vr6 154 3 on on IN cord-258021-xhx74vr6 154 4 point point NN cord-258021-xhx74vr6 154 5 - - HYPH cord-258021-xhx74vr6 154 6 of of IN cord-258021-xhx74vr6 154 7 - - HYPH cord-258021-xhx74vr6 154 8 care care NN cord-258021-xhx74vr6 154 9 testing testing NN cord-258021-xhx74vr6 154 10 , , , cord-258021-xhx74vr6 154 11 or or CC cord-258021-xhx74vr6 154 12 at at IN cord-258021-xhx74vr6 154 13 least least JJS cord-258021-xhx74vr6 154 14 rapid rapid JJ cord-258021-xhx74vr6 154 15 enough enough JJ cord-258021-xhx74vr6 154 16 turnaround turnaround NN cord-258021-xhx74vr6 154 17 time time NN cord-258021-xhx74vr6 154 18 to to TO cord-258021-xhx74vr6 154 19 influence influence VB cord-258021-xhx74vr6 154 20 initial initial JJ cord-258021-xhx74vr6 154 21 clinical clinical JJ cord-258021-xhx74vr6 154 22 management management NN cord-258021-xhx74vr6 154 23 , , , cord-258021-xhx74vr6 154 24 has have VBZ cord-258021-xhx74vr6 154 25 driven drive VBN cord-258021-xhx74vr6 154 26 development development NN cord-258021-xhx74vr6 154 27 of of IN cord-258021-xhx74vr6 154 28 a a DT cord-258021-xhx74vr6 154 29 host host NN cord-258021-xhx74vr6 154 30 of of IN cord-258021-xhx74vr6 154 31 new new JJ cord-258021-xhx74vr6 154 32 platforms platform NNS cord-258021-xhx74vr6 154 33 and and CC cord-258021-xhx74vr6 154 34 technologies technology NNS cord-258021-xhx74vr6 154 35 that that WDT cord-258021-xhx74vr6 154 36 are be VBP cord-258021-xhx74vr6 154 37 likely likely JJ cord-258021-xhx74vr6 154 38 to to TO cord-258021-xhx74vr6 154 39 change change VB cord-258021-xhx74vr6 154 40 the the DT cord-258021-xhx74vr6 154 41 way way NN cord-258021-xhx74vr6 154 42 we -PRON- PRP cord-258021-xhx74vr6 154 43 manage manage VBP cord-258021-xhx74vr6 154 44 pneumonia pneumonia NN cord-258021-xhx74vr6 154 45 over over IN cord-258021-xhx74vr6 154 46 the the DT cord-258021-xhx74vr6 154 47 coming come VBG cord-258021-xhx74vr6 154 48 decade decade NN cord-258021-xhx74vr6 154 49 . . . cord-258021-xhx74vr6 155 1 The the DT cord-258021-xhx74vr6 155 2 etiology etiology NN cord-258021-xhx74vr6 155 3 of of IN cord-258021-xhx74vr6 155 4 swine swine NN cord-258021-xhx74vr6 155 5 influenza influenza NN cord-258021-xhx74vr6 155 6 Communityacquired Communityacquired NNP cord-258021-xhx74vr6 155 7 pneumonia pneumonia NN cord-258021-xhx74vr6 155 8 requiring require VBG cord-258021-xhx74vr6 155 9 hospitalization hospitalization NN cord-258021-xhx74vr6 155 10 among among IN cord-258021-xhx74vr6 155 11 U.S. U.S. NNP cord-258021-xhx74vr6 155 12 adults adult NNS cord-258021-xhx74vr6 155 13 Etiology etiology NN cord-258021-xhx74vr6 155 14 of of IN cord-258021-xhx74vr6 155 15 community community NN cord-258021-xhx74vr6 155 16 - - HYPH cord-258021-xhx74vr6 155 17 acquired acquire VBN cord-258021-xhx74vr6 155 18 pneumonia pneumonia NN cord-258021-xhx74vr6 155 19 and and CC cord-258021-xhx74vr6 155 20 diagnostic diagnostic JJ cord-258021-xhx74vr6 155 21 yields yield NNS cord-258021-xhx74vr6 155 22 of of IN cord-258021-xhx74vr6 155 23 microbiological microbiological JJ cord-258021-xhx74vr6 155 24 methods method NNS cord-258021-xhx74vr6 155 25 : : : cord-258021-xhx74vr6 155 26 a a DT cord-258021-xhx74vr6 155 27 3-year 3-year CD cord-258021-xhx74vr6 155 28 prospective prospective JJ cord-258021-xhx74vr6 155 29 study study NN cord-258021-xhx74vr6 155 30 in in IN cord-258021-xhx74vr6 155 31 Norway Norway NNP cord-258021-xhx74vr6 155 32 Studies Studies NNP cord-258021-xhx74vr6 155 33 on on IN cord-258021-xhx74vr6 155 34 the the DT cord-258021-xhx74vr6 155 35 etiology etiology NN cord-258021-xhx74vr6 155 36 of of IN cord-258021-xhx74vr6 155 37 primary primary JJ cord-258021-xhx74vr6 155 38 atypical atypical JJ cord-258021-xhx74vr6 155 39 pneumonia pneumonia NN cord-258021-xhx74vr6 155 40 : : : cord-258021-xhx74vr6 155 41 a a DT cord-258021-xhx74vr6 155 42 filterable filterable JJ cord-258021-xhx74vr6 155 43 agent agent NN cord-258021-xhx74vr6 155 44 transmissible transmissible JJ cord-258021-xhx74vr6 155 45 to to IN cord-258021-xhx74vr6 155 46 cotton cotton NN cord-258021-xhx74vr6 155 47 rats rat NNS cord-258021-xhx74vr6 155 48 , , , cord-258021-xhx74vr6 155 49 hamsters hamster NNS cord-258021-xhx74vr6 155 50 and and CC cord-258021-xhx74vr6 155 51 chick chick NN cord-258021-xhx74vr6 155 52 embryos embryo NNS cord-258021-xhx74vr6 155 53 Legionnaires Legionnaires NNPS cord-258021-xhx74vr6 155 54 ' ' POS cord-258021-xhx74vr6 155 55 disease disease NN cord-258021-xhx74vr6 155 56 : : : cord-258021-xhx74vr6 155 57 isolation isolation NN cord-258021-xhx74vr6 155 58 of of IN cord-258021-xhx74vr6 155 59 a a DT cord-258021-xhx74vr6 155 60 bacterium bacterium NN cord-258021-xhx74vr6 155 61 and and CC cord-258021-xhx74vr6 155 62 demonstration demonstration NN cord-258021-xhx74vr6 155 63 of of IN cord-258021-xhx74vr6 155 64 its -PRON- PRP$ cord-258021-xhx74vr6 155 65 role role NN cord-258021-xhx74vr6 155 66 in in IN cord-258021-xhx74vr6 155 67 other other JJ cord-258021-xhx74vr6 155 68 respiratory respiratory JJ cord-258021-xhx74vr6 155 69 disease disease NN cord-258021-xhx74vr6 156 1 A a DT cord-258021-xhx74vr6 156 2 new new JJ cord-258021-xhx74vr6 156 3 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 156 4 psittaci psittaci NN cord-258021-xhx74vr6 156 5 strain strain NN cord-258021-xhx74vr6 156 6 , , , cord-258021-xhx74vr6 156 7 TWAR TWAR NNP cord-258021-xhx74vr6 156 8 , , , cord-258021-xhx74vr6 156 9 isolated isolate VBN cord-258021-xhx74vr6 156 10 in in IN cord-258021-xhx74vr6 156 11 acute acute JJ cord-258021-xhx74vr6 156 12 respiratory respiratory JJ cord-258021-xhx74vr6 156 13 tract tract NN cord-258021-xhx74vr6 156 14 infections infection NNS cord-258021-xhx74vr6 156 15 Clinical clinical JJ cord-258021-xhx74vr6 156 16 symptoms symptom NNS cord-258021-xhx74vr6 156 17 and and CC cord-258021-xhx74vr6 156 18 signs sign NNS cord-258021-xhx74vr6 156 19 for for IN cord-258021-xhx74vr6 156 20 the the DT cord-258021-xhx74vr6 156 21 diagnosis diagnosis NN cord-258021-xhx74vr6 156 22 of of IN cord-258021-xhx74vr6 156 23 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 156 24 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 156 25 in in IN cord-258021-xhx74vr6 156 26 children child NNS cord-258021-xhx74vr6 156 27 and and CC cord-258021-xhx74vr6 156 28 adolescents adolescent NNS cord-258021-xhx74vr6 156 29 with with IN cord-258021-xhx74vr6 156 30 communityacquired communityacquired JJ cord-258021-xhx74vr6 156 31 pneumonia pneumonia NN cord-258021-xhx74vr6 156 32 Legionella Legionella NNP cord-258021-xhx74vr6 156 33 pneumonia pneumonia NN cord-258021-xhx74vr6 156 34 cases case VBZ cord-258021-xhx74vr6 156 35 over over IN cord-258021-xhx74vr6 156 36 a a DT cord-258021-xhx74vr6 156 37 five five CD cord-258021-xhx74vr6 156 38 - - HYPH cord-258021-xhx74vr6 156 39 year year NN cord-258021-xhx74vr6 156 40 period period NN cord-258021-xhx74vr6 156 41 : : : cord-258021-xhx74vr6 156 42 a a DT cord-258021-xhx74vr6 156 43 descriptive descriptive JJ cord-258021-xhx74vr6 156 44 , , , cord-258021-xhx74vr6 156 45 retrospective retrospective JJ cord-258021-xhx74vr6 156 46 study study NN cord-258021-xhx74vr6 156 47 of of IN cord-258021-xhx74vr6 156 48 outcomes outcome NNS cord-258021-xhx74vr6 156 49 in in IN cord-258021-xhx74vr6 156 50 a a DT cord-258021-xhx74vr6 156 51 UK UK NNP cord-258021-xhx74vr6 156 52 district district NN cord-258021-xhx74vr6 156 53 hospital hospital NN cord-258021-xhx74vr6 156 54 Community Community NNP cord-258021-xhx74vr6 156 55 - - HYPH cord-258021-xhx74vr6 156 56 acquired acquire VBN cord-258021-xhx74vr6 156 57 Legionella Legionella NNP cord-258021-xhx74vr6 156 58 pneumophila pneumophila NN cord-258021-xhx74vr6 156 59 pneumonia pneumonia NN cord-258021-xhx74vr6 156 60 : : : cord-258021-xhx74vr6 156 61 a a DT cord-258021-xhx74vr6 156 62 single single JJ cord-258021-xhx74vr6 156 63 - - HYPH cord-258021-xhx74vr6 156 64 center center NN cord-258021-xhx74vr6 156 65 experience experience NN cord-258021-xhx74vr6 156 66 with with IN cord-258021-xhx74vr6 156 67 214 214 CD cord-258021-xhx74vr6 156 68 hospitalized hospitalize VBN cord-258021-xhx74vr6 156 69 sporadic sporadic JJ cord-258021-xhx74vr6 156 70 cases case NNS cord-258021-xhx74vr6 156 71 over over IN cord-258021-xhx74vr6 156 72 15 15 CD cord-258021-xhx74vr6 156 73 years year NNS cord-258021-xhx74vr6 157 1 Comparative comparative JJ cord-258021-xhx74vr6 157 2 study study NN cord-258021-xhx74vr6 157 3 of of IN cord-258021-xhx74vr6 157 4 the the DT cord-258021-xhx74vr6 157 5 clinical clinical JJ cord-258021-xhx74vr6 157 6 presentation presentation NN cord-258021-xhx74vr6 157 7 of of IN cord-258021-xhx74vr6 157 8 Legionella Legionella NNP cord-258021-xhx74vr6 157 9 pneumonia pneumonia NN cord-258021-xhx74vr6 157 10 and and CC cord-258021-xhx74vr6 157 11 other other JJ cord-258021-xhx74vr6 157 12 community community NN cord-258021-xhx74vr6 157 13 - - HYPH cord-258021-xhx74vr6 157 14 acquired acquire VBN cord-258021-xhx74vr6 157 15 pneumonias pneumonia NNS cord-258021-xhx74vr6 157 16 Usefulness Usefulness NNP cord-258021-xhx74vr6 157 17 of of IN cord-258021-xhx74vr6 157 18 procalcitonin procalcitonin NNS cord-258021-xhx74vr6 157 19 to to TO cord-258021-xhx74vr6 157 20 differentiate differentiate VB cord-258021-xhx74vr6 157 21 typical typical JJ cord-258021-xhx74vr6 157 22 from from IN cord-258021-xhx74vr6 157 23 atypical atypical JJ cord-258021-xhx74vr6 157 24 communityacquired communityacquired JJ cord-258021-xhx74vr6 157 25 pneumonia pneumonia NN cord-258021-xhx74vr6 157 26 Procalcitonin Procalcitonin NNP cord-258021-xhx74vr6 157 27 predicts predict VBZ cord-258021-xhx74vr6 157 28 patients patient NNS cord-258021-xhx74vr6 157 29 at at IN cord-258021-xhx74vr6 157 30 low low JJ cord-258021-xhx74vr6 157 31 risk risk NN cord-258021-xhx74vr6 157 32 of of IN cord-258021-xhx74vr6 157 33 death death NN cord-258021-xhx74vr6 157 34 from from IN cord-258021-xhx74vr6 157 35 communityacquired communityacquired JJ cord-258021-xhx74vr6 157 36 pneumonia pneumonia NN cord-258021-xhx74vr6 157 37 across across IN cord-258021-xhx74vr6 157 38 all all DT cord-258021-xhx74vr6 157 39 CRB-65 CRB-65 NNP cord-258021-xhx74vr6 157 40 classes class NNS cord-258021-xhx74vr6 157 41 Can Can MD cord-258021-xhx74vr6 157 42 procalcitonin procalcitonin JJ cord-258021-xhx74vr6 157 43 tests test NNS cord-258021-xhx74vr6 157 44 aid aid VB cord-258021-xhx74vr6 157 45 in in IN cord-258021-xhx74vr6 157 46 identifying identify VBG cord-258021-xhx74vr6 157 47 bacterial bacterial JJ cord-258021-xhx74vr6 157 48 infections infection NNS cord-258021-xhx74vr6 157 49 associated associate VBN cord-258021-xhx74vr6 157 50 with with IN cord-258021-xhx74vr6 157 51 influenza influenza NN cord-258021-xhx74vr6 157 52 pneumonia pneumonia NN cord-258021-xhx74vr6 157 53 ? ? . cord-258021-xhx74vr6 158 1 A a DT cord-258021-xhx74vr6 158 2 systematic systematic JJ cord-258021-xhx74vr6 158 3 review review NN cord-258021-xhx74vr6 158 4 and and CC cord-258021-xhx74vr6 158 5 meta meta NNP cord-258021-xhx74vr6 158 6 - - HYPH cord-258021-xhx74vr6 158 7 analysis analysis NN cord-258021-xhx74vr6 158 8 Legionella Legionella NNP cord-258021-xhx74vr6 158 9 and and CC cord-258021-xhx74vr6 158 10 community community NN cord-258021-xhx74vr6 158 11 - - HYPH cord-258021-xhx74vr6 158 12 acquired acquire VBN cord-258021-xhx74vr6 158 13 pneumonia pneumonia NN cord-258021-xhx74vr6 158 14 : : : cord-258021-xhx74vr6 158 15 a a DT cord-258021-xhx74vr6 158 16 review review NN cord-258021-xhx74vr6 158 17 of of IN cord-258021-xhx74vr6 158 18 current current JJ cord-258021-xhx74vr6 158 19 diagnostic diagnostic JJ cord-258021-xhx74vr6 158 20 tests test NNS cord-258021-xhx74vr6 158 21 from from IN cord-258021-xhx74vr6 158 22 a a DT cord-258021-xhx74vr6 158 23 clinician clinician NN cord-258021-xhx74vr6 158 24 's 's POS cord-258021-xhx74vr6 158 25 viewpoint viewpoint JJ cord-258021-xhx74vr6 158 26 Enhanced enhanced JJ cord-258021-xhx74vr6 158 27 detection detection NN cord-258021-xhx74vr6 158 28 of of IN cord-258021-xhx74vr6 158 29 Legionnaires legionnaire NNS cord-258021-xhx74vr6 158 30 ' ' POS cord-258021-xhx74vr6 158 31 disease disease NN cord-258021-xhx74vr6 158 32 by by IN cord-258021-xhx74vr6 158 33 PCR PCR NNP cord-258021-xhx74vr6 158 34 testing testing NN cord-258021-xhx74vr6 158 35 of of IN cord-258021-xhx74vr6 158 36 induced induce VBN cord-258021-xhx74vr6 158 37 sputum sputum NN cord-258021-xhx74vr6 158 38 and and CC cord-258021-xhx74vr6 158 39 throat throat NN cord-258021-xhx74vr6 158 40 swabs swab NNS cord-258021-xhx74vr6 158 41 Legionellosis Legionellosis NNP cord-258021-xhx74vr6 158 42 -United -unite VBD cord-258021-xhx74vr6 158 43 States States NNP cord-258021-xhx74vr6 158 44 Summary Summary NNP cord-258021-xhx74vr6 158 45 of of IN cord-258021-xhx74vr6 158 46 notifiable notifiable JJ cord-258021-xhx74vr6 158 47 infectious infectious JJ cord-258021-xhx74vr6 158 48 diseases disease NNS cord-258021-xhx74vr6 158 49 and and CC cord-258021-xhx74vr6 158 50 conditions condition NNS cord-258021-xhx74vr6 159 1 -United -unite VBN cord-258021-xhx74vr6 160 1 States state NNS cord-258021-xhx74vr6 161 1 Vital vital JJ cord-258021-xhx74vr6 161 2 signs sign NNS cord-258021-xhx74vr6 161 3 : : : cord-258021-xhx74vr6 161 4 deficiencies deficiency NNS cord-258021-xhx74vr6 161 5 in in IN cord-258021-xhx74vr6 161 6 environmental environmental JJ cord-258021-xhx74vr6 161 7 control control NN cord-258021-xhx74vr6 161 8 identified identify VBN cord-258021-xhx74vr6 161 9 in in IN cord-258021-xhx74vr6 161 10 outbreaks outbreak NNS cord-258021-xhx74vr6 161 11 of of IN cord-258021-xhx74vr6 161 12 legionnaires legionnaire NNS cord-258021-xhx74vr6 161 13 ' ' POS cord-258021-xhx74vr6 161 14 disease disease NN cord-258021-xhx74vr6 161 15 -North -North NNP cord-258021-xhx74vr6 161 16 America America NNP cord-258021-xhx74vr6 161 17 Laboratory Laboratory NNP cord-258021-xhx74vr6 161 18 diagnosis diagnosis NN cord-258021-xhx74vr6 161 19 of of IN cord-258021-xhx74vr6 161 20 Legionnaires Legionnaires NNPS cord-258021-xhx74vr6 161 21 ' ' POS cord-258021-xhx74vr6 161 22 disease disease NN cord-258021-xhx74vr6 161 23 Diagnosis Diagnosis NNP cord-258021-xhx74vr6 161 24 of of IN cord-258021-xhx74vr6 161 25 Legionnaires Legionnaires NNPS cord-258021-xhx74vr6 161 26 ' ' POS cord-258021-xhx74vr6 161 27 disease disease NN cord-258021-xhx74vr6 161 28 . . . cord-258021-xhx74vr6 162 1 An an DT cord-258021-xhx74vr6 162 2 update update NN cord-258021-xhx74vr6 162 3 of of IN cord-258021-xhx74vr6 162 4 laboratory laboratory NN cord-258021-xhx74vr6 162 5 methods method NNS cord-258021-xhx74vr6 162 6 with with IN cord-258021-xhx74vr6 162 7 new new JJ cord-258021-xhx74vr6 162 8 emphasis emphasis NN cord-258021-xhx74vr6 162 9 on on IN cord-258021-xhx74vr6 162 10 isolation isolation NN cord-258021-xhx74vr6 162 11 by by IN cord-258021-xhx74vr6 162 12 culture culture NN cord-258021-xhx74vr6 162 13 Delayed delay VBN cord-258021-xhx74vr6 162 14 seroconversion seroconversion NN cord-258021-xhx74vr6 162 15 in in IN cord-258021-xhx74vr6 162 16 Legionnaire Legionnaire NNP cord-258021-xhx74vr6 162 17 's 's POS cord-258021-xhx74vr6 162 18 disease disease NN cord-258021-xhx74vr6 162 19 Infectious Infectious NNP cord-258021-xhx74vr6 162 20 Diseases Diseases NNPS cord-258021-xhx74vr6 162 21 Society Society NNP cord-258021-xhx74vr6 162 22 of of IN cord-258021-xhx74vr6 162 23 America America NNP cord-258021-xhx74vr6 162 24 / / SYM cord-258021-xhx74vr6 162 25 American American NNP cord-258021-xhx74vr6 162 26 Thoracic Thoracic NNP cord-258021-xhx74vr6 162 27 Society Society NNP cord-258021-xhx74vr6 162 28 consensus consensus NN cord-258021-xhx74vr6 162 29 guidelines guideline NNS cord-258021-xhx74vr6 162 30 on on IN cord-258021-xhx74vr6 162 31 the the DT cord-258021-xhx74vr6 162 32 management management NN cord-258021-xhx74vr6 162 33 of of IN cord-258021-xhx74vr6 162 34 community community NN cord-258021-xhx74vr6 162 35 - - HYPH cord-258021-xhx74vr6 162 36 acquired acquire VBN cord-258021-xhx74vr6 162 37 pneumonia pneumonia NN cord-258021-xhx74vr6 162 38 in in IN cord-258021-xhx74vr6 162 39 adults adult NNS cord-258021-xhx74vr6 162 40 Diagnostic diagnostic JJ cord-258021-xhx74vr6 162 41 accuracy accuracy NN cord-258021-xhx74vr6 162 42 of of IN cord-258021-xhx74vr6 162 43 PCR PCR NNP cord-258021-xhx74vr6 162 44 alone alone RB cord-258021-xhx74vr6 162 45 and and CC cord-258021-xhx74vr6 162 46 compared compare VBN cord-258021-xhx74vr6 162 47 to to IN cord-258021-xhx74vr6 162 48 urinary urinary JJ cord-258021-xhx74vr6 162 49 antigen antigen NN cord-258021-xhx74vr6 162 50 testing testing NN cord-258021-xhx74vr6 162 51 for for IN cord-258021-xhx74vr6 162 52 detection detection NN cord-258021-xhx74vr6 162 53 of of IN cord-258021-xhx74vr6 162 54 Legionella Legionella NNP cord-258021-xhx74vr6 162 55 spp spp NNS cord-258021-xhx74vr6 162 56 . . . cord-258021-xhx74vr6 163 1 : : : cord-258021-xhx74vr6 163 2 a a DT cord-258021-xhx74vr6 163 3 systematic systematic JJ cord-258021-xhx74vr6 163 4 review review NN cord-258021-xhx74vr6 163 5 Rapid Rapid NNP cord-258021-xhx74vr6 163 6 detection detection NN cord-258021-xhx74vr6 163 7 and and CC cord-258021-xhx74vr6 163 8 typing typing NN cord-258021-xhx74vr6 163 9 of of IN cord-258021-xhx74vr6 163 10 pathogenic pathogenic JJ cord-258021-xhx74vr6 163 11 nonpneumophila nonpneumophila JJ cord-258021-xhx74vr6 163 12 Legionella Legionella NNP cord-258021-xhx74vr6 163 13 spp spp NNS cord-258021-xhx74vr6 163 14 . . . cord-258021-xhx74vr6 164 1 isolates isolate NNS cord-258021-xhx74vr6 164 2 using use VBG cord-258021-xhx74vr6 164 3 a a DT cord-258021-xhx74vr6 164 4 multiplex multiplex JJ cord-258021-xhx74vr6 164 5 real real JJ cord-258021-xhx74vr6 164 6 - - HYPH cord-258021-xhx74vr6 164 7 time time NN cord-258021-xhx74vr6 164 8 PCR PCR NNP cord-258021-xhx74vr6 164 9 assay assay NN cord-258021-xhx74vr6 164 10 Prospective prospective JJ cord-258021-xhx74vr6 164 11 evaluation evaluation NN cord-258021-xhx74vr6 164 12 of of IN cord-258021-xhx74vr6 164 13 RT RT NNP cord-258021-xhx74vr6 164 14 - - HYPH cord-258021-xhx74vr6 164 15 PCR PCR NNP cord-258021-xhx74vr6 164 16 on on IN cord-258021-xhx74vr6 164 17 sputum sputum NN cord-258021-xhx74vr6 164 18 versus versus IN cord-258021-xhx74vr6 164 19 culture culture NN cord-258021-xhx74vr6 164 20 , , , cord-258021-xhx74vr6 164 21 urinary urinary JJ cord-258021-xhx74vr6 164 22 antigens antigen NNS cord-258021-xhx74vr6 164 23 and and CC cord-258021-xhx74vr6 164 24 serology serology NN cord-258021-xhx74vr6 164 25 for for IN cord-258021-xhx74vr6 164 26 Legionnaire Legionnaire NNP cord-258021-xhx74vr6 164 27 's 's POS cord-258021-xhx74vr6 164 28 disease disease NN cord-258021-xhx74vr6 164 29 diagnosis diagnosis NN cord-258021-xhx74vr6 164 30 Comprehensive Comprehensive NNP cord-258021-xhx74vr6 164 31 molecular molecular JJ cord-258021-xhx74vr6 164 32 testing testing NN cord-258021-xhx74vr6 164 33 for for IN cord-258021-xhx74vr6 164 34 respiratory respiratory JJ cord-258021-xhx74vr6 164 35 pathogens pathogen NNS cord-258021-xhx74vr6 164 36 in in IN cord-258021-xhx74vr6 164 37 community community NN cord-258021-xhx74vr6 164 38 - - HYPH cord-258021-xhx74vr6 164 39 acquired acquire VBN cord-258021-xhx74vr6 164 40 pneumonia pneumonia NN cord-258021-xhx74vr6 164 41 Non non JJ cord-258021-xhx74vr6 164 42 - - JJ cord-258021-xhx74vr6 164 43 invasive invasive JJ cord-258021-xhx74vr6 164 44 sample sample NN cord-258021-xhx74vr6 164 45 collection collection NN cord-258021-xhx74vr6 164 46 for for IN cord-258021-xhx74vr6 164 47 respiratory respiratory JJ cord-258021-xhx74vr6 164 48 virus virus NN cord-258021-xhx74vr6 164 49 testing testing NN cord-258021-xhx74vr6 164 50 by by IN cord-258021-xhx74vr6 164 51 multiplex multiplex NN cord-258021-xhx74vr6 164 52 PCR PCR NNP cord-258021-xhx74vr6 164 53 Comparison comparison NN cord-258021-xhx74vr6 164 54 of of IN cord-258021-xhx74vr6 164 55 serological serological JJ cord-258021-xhx74vr6 164 56 methods method NNS cord-258021-xhx74vr6 164 57 with with IN cord-258021-xhx74vr6 164 58 PCR PCR NNP cord-258021-xhx74vr6 164 59 - - HYPH cord-258021-xhx74vr6 164 60 based base VBN cord-258021-xhx74vr6 164 61 methods method NNS cord-258021-xhx74vr6 164 62 for for IN cord-258021-xhx74vr6 164 63 the the DT cord-258021-xhx74vr6 164 64 diagnosis diagnosis NN cord-258021-xhx74vr6 164 65 of of IN cord-258021-xhx74vr6 164 66 community community NN cord-258021-xhx74vr6 164 67 - - HYPH cord-258021-xhx74vr6 164 68 acquired acquire VBN cord-258021-xhx74vr6 164 69 pneumonia pneumonia NN cord-258021-xhx74vr6 164 70 caused cause VBN cord-258021-xhx74vr6 164 71 by by IN cord-258021-xhx74vr6 164 72 atypical atypical JJ cord-258021-xhx74vr6 164 73 bacteria bacteria NNS cord-258021-xhx74vr6 164 74 Comparison comparison NN cord-258021-xhx74vr6 164 75 of of IN cord-258021-xhx74vr6 164 76 sputum sputum NN cord-258021-xhx74vr6 164 77 and and CC cord-258021-xhx74vr6 164 78 nasopharyngeal nasopharyngeal JJ cord-258021-xhx74vr6 164 79 swab swab NN cord-258021-xhx74vr6 164 80 specimens specimen NNS cord-258021-xhx74vr6 164 81 for for IN cord-258021-xhx74vr6 164 82 molecular molecular JJ cord-258021-xhx74vr6 164 83 diagnosis diagnosis NN cord-258021-xhx74vr6 164 84 of of IN cord-258021-xhx74vr6 164 85 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 164 86 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 164 87 , , , cord-258021-xhx74vr6 164 88 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 164 89 pneumoniae pneumoniae NN cord-258021-xhx74vr6 164 90 , , , cord-258021-xhx74vr6 164 91 and and CC cord-258021-xhx74vr6 164 92 Legionella Legionella NNP cord-258021-xhx74vr6 164 93 pneumophila pneumophila VBD cord-258021-xhx74vr6 164 94 A a DT cord-258021-xhx74vr6 164 95 compendium compendium NN cord-258021-xhx74vr6 164 96 for for IN cord-258021-xhx74vr6 164 97 Mycoplasma mycoplasma NN cord-258021-xhx74vr6 164 98 pneumoniae pneumoniae NN cord-258021-xhx74vr6 164 99 Evaluation Evaluation NNP cord-258021-xhx74vr6 164 100 of of IN cord-258021-xhx74vr6 164 101 different different JJ cord-258021-xhx74vr6 164 102 nucleic nucleic JJ cord-258021-xhx74vr6 164 103 acid acid NN cord-258021-xhx74vr6 164 104 amplification amplification NN cord-258021-xhx74vr6 164 105 techniques technique NNS cord-258021-xhx74vr6 164 106 for for IN cord-258021-xhx74vr6 164 107 the the DT cord-258021-xhx74vr6 164 108 detection detection NN cord-258021-xhx74vr6 164 109 of of IN cord-258021-xhx74vr6 164 110 M. M. NNP cord-258021-xhx74vr6 164 111 pneumoniae pneumoniae NN cord-258021-xhx74vr6 164 112 , , , cord-258021-xhx74vr6 164 113 C. C. NNP cord-258021-xhx74vr6 164 114 pneumoniae pneumoniae NN cord-258021-xhx74vr6 164 115 and and CC cord-258021-xhx74vr6 164 116 Legionella Legionella NNP cord-258021-xhx74vr6 164 117 spp spp NNS cord-258021-xhx74vr6 164 118 . . . cord-258021-xhx74vr6 165 1 in in IN cord-258021-xhx74vr6 165 2 respiratory respiratory JJ cord-258021-xhx74vr6 165 3 specimens specimen NNS cord-258021-xhx74vr6 165 4 from from IN cord-258021-xhx74vr6 165 5 patients patient NNS cord-258021-xhx74vr6 165 6 with with IN cord-258021-xhx74vr6 165 7 community community NN cord-258021-xhx74vr6 165 8 - - HYPH cord-258021-xhx74vr6 165 9 acquired acquire VBN cord-258021-xhx74vr6 165 10 pneumonia pneumonia NN cord-258021-xhx74vr6 166 1 A a DT cord-258021-xhx74vr6 166 2 comparison comparison NN cord-258021-xhx74vr6 166 3 of of IN cord-258021-xhx74vr6 166 4 molecular molecular JJ cord-258021-xhx74vr6 166 5 assays assay NNS cord-258021-xhx74vr6 166 6 for for IN cord-258021-xhx74vr6 166 7 Mycoplasma mycoplasma NN cord-258021-xhx74vr6 166 8 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 166 9 in in IN cord-258021-xhx74vr6 166 10 pediatric pediatric JJ cord-258021-xhx74vr6 166 11 patients patient NNS cord-258021-xhx74vr6 166 12 Rapid rapid JJ cord-258021-xhx74vr6 166 13 diagnosis diagnosis NN cord-258021-xhx74vr6 166 14 of of IN cord-258021-xhx74vr6 166 15 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 166 16 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 166 17 in in IN cord-258021-xhx74vr6 166 18 children child NNS cord-258021-xhx74vr6 166 19 with with IN cord-258021-xhx74vr6 166 20 pneumonia pneumonia NN cord-258021-xhx74vr6 166 21 by by IN cord-258021-xhx74vr6 166 22 an an DT cord-258021-xhx74vr6 166 23 immuno immuno JJ cord-258021-xhx74vr6 166 24 - - JJ cord-258021-xhx74vr6 166 25 chromatographic chromatographic JJ cord-258021-xhx74vr6 166 26 antigen antigen NN cord-258021-xhx74vr6 166 27 assay assay NN cord-258021-xhx74vr6 166 28 Rapid Rapid NNP cord-258021-xhx74vr6 166 29 diagnostic diagnostic JJ cord-258021-xhx74vr6 166 30 method method NN cord-258021-xhx74vr6 166 31 for for IN cord-258021-xhx74vr6 166 32 the the DT cord-258021-xhx74vr6 166 33 identification identification NN cord-258021-xhx74vr6 166 34 of of IN cord-258021-xhx74vr6 166 35 Mycoplasma Mycoplasma NNP cord-258021-xhx74vr6 166 36 pneumoniae pneumoniae NN cord-258021-xhx74vr6 166 37 respiratory respiratory JJ cord-258021-xhx74vr6 166 38 tract tract NN cord-258021-xhx74vr6 166 39 infection infection NN cord-258021-xhx74vr6 167 1 Genus genus NN cord-258021-xhx74vr6 167 2 delineation delineation NN cord-258021-xhx74vr6 167 3 of of IN cord-258021-xhx74vr6 167 4 Chlamydiales Chlamydiales NNP cord-258021-xhx74vr6 167 5 by by IN cord-258021-xhx74vr6 167 6 analysis analysis NN cord-258021-xhx74vr6 167 7 of of IN cord-258021-xhx74vr6 167 8 the the DT cord-258021-xhx74vr6 167 9 percentage percentage NN cord-258021-xhx74vr6 167 10 of of IN cord-258021-xhx74vr6 167 11 conserved conserve VBN cord-258021-xhx74vr6 167 12 proteins protein NNS cord-258021-xhx74vr6 167 13 ( ( -LRB- cord-258021-xhx74vr6 167 14 POCP POCP NNP cord-258021-xhx74vr6 167 15 ) ) -RRB- cord-258021-xhx74vr6 167 16 justifies justify VBZ cord-258021-xhx74vr6 167 17 the the DT cord-258021-xhx74vr6 167 18 reunifying reunifying NN cord-258021-xhx74vr6 167 19 of of IN cord-258021-xhx74vr6 167 20 the the DT cord-258021-xhx74vr6 167 21 genera genera NNP cord-258021-xhx74vr6 167 22 Chlamydia Chlamydia NNPS cord-258021-xhx74vr6 167 23 and and CC cord-258021-xhx74vr6 167 24 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 167 25 into into IN cord-258021-xhx74vr6 167 26 one one CD cord-258021-xhx74vr6 167 27 single single JJ cord-258021-xhx74vr6 167 28 genus genus NN cord-258021-xhx74vr6 167 29 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 167 30 Infections infection NNS cord-258021-xhx74vr6 167 31 with with IN cord-258021-xhx74vr6 167 32 the the DT cord-258021-xhx74vr6 167 33 chlamydia chlamydia NNS cord-258021-xhx74vr6 167 34 - - HYPH cord-258021-xhx74vr6 167 35 like like JJ cord-258021-xhx74vr6 167 36 microorganism microorganism NN cord-258021-xhx74vr6 167 37 Simkania Simkania NNP cord-258021-xhx74vr6 167 38 negevensis negevensis NN cord-258021-xhx74vr6 167 39 , , , cord-258021-xhx74vr6 167 40 a a DT cord-258021-xhx74vr6 167 41 possible possible JJ cord-258021-xhx74vr6 167 42 emerging emerge VBG cord-258021-xhx74vr6 167 43 pathogen pathogen NN cord-258021-xhx74vr6 167 44 Parachlamydia Parachlamydia NNP cord-258021-xhx74vr6 167 45 acanthamoebae acanthamoebae NN cord-258021-xhx74vr6 167 46 , , , cord-258021-xhx74vr6 167 47 an an DT cord-258021-xhx74vr6 167 48 emerging emerge VBG cord-258021-xhx74vr6 167 49 agent agent NN cord-258021-xhx74vr6 167 50 of of IN cord-258021-xhx74vr6 167 51 pneumonia pneumonia NN cord-258021-xhx74vr6 167 52 Serological serological JJ cord-258021-xhx74vr6 167 53 diagnosis diagnosis NN cord-258021-xhx74vr6 167 54 of of IN cord-258021-xhx74vr6 167 55 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 167 56 pneumoniae pneumoniae NN cord-258021-xhx74vr6 167 57 infection infection NN cord-258021-xhx74vr6 167 58 : : : cord-258021-xhx74vr6 167 59 limitations limitation NNS cord-258021-xhx74vr6 167 60 and and CC cord-258021-xhx74vr6 167 61 perspectives perspective NNS cord-258021-xhx74vr6 167 62 Comparison comparison NN cord-258021-xhx74vr6 167 63 of of IN cord-258021-xhx74vr6 167 64 real real JJ cord-258021-xhx74vr6 167 65 - - HYPH cord-258021-xhx74vr6 167 66 time time NN cord-258021-xhx74vr6 167 67 PCR PCR NNP cord-258021-xhx74vr6 167 68 and and CC cord-258021-xhx74vr6 167 69 a a DT cord-258021-xhx74vr6 167 70 microimmunofluorescence microimmunofluorescence NN cord-258021-xhx74vr6 167 71 serological serological JJ cord-258021-xhx74vr6 167 72 assay assay NN cord-258021-xhx74vr6 167 73 for for IN cord-258021-xhx74vr6 167 74 detection detection NN cord-258021-xhx74vr6 167 75 of of IN cord-258021-xhx74vr6 167 76 chlamydophila chlamydophila NN cord-258021-xhx74vr6 167 77 pneumoniae pneumoniae NN cord-258021-xhx74vr6 167 78 infection infection NN cord-258021-xhx74vr6 167 79 in in IN cord-258021-xhx74vr6 167 80 an an DT cord-258021-xhx74vr6 167 81 outbreak outbreak NN cord-258021-xhx74vr6 167 82 investigation investigation NN cord-258021-xhx74vr6 167 83 Limited limited JJ cord-258021-xhx74vr6 167 84 utility utility NN cord-258021-xhx74vr6 167 85 of of IN cord-258021-xhx74vr6 167 86 culture culture NN cord-258021-xhx74vr6 167 87 for for IN cord-258021-xhx74vr6 167 88 Mycoplasma mycoplasma NN cord-258021-xhx74vr6 167 89 pneumoniae pneumoniae NNS cord-258021-xhx74vr6 167 90 and and CC cord-258021-xhx74vr6 167 91 Chlamydophila Chlamydophila NNP cord-258021-xhx74vr6 167 92 pneumoniae pneumoniae NN cord-258021-xhx74vr6 167 93 for for IN cord-258021-xhx74vr6 167 94 diagnosis diagnosis NN cord-258021-xhx74vr6 167 95 of of IN cord-258021-xhx74vr6 167 96 respiratory respiratory JJ cord-258021-xhx74vr6 167 97 tract tract NN cord-258021-xhx74vr6 167 98 infections infection NNS cord-258021-xhx74vr6 167 99 Microbiological microbiological JJ cord-258021-xhx74vr6 167 100 diagnosis diagnosis NN cord-258021-xhx74vr6 167 101 of of IN cord-258021-xhx74vr6 167 102 infections infection NNS cord-258021-xhx74vr6 167 103 due due JJ cord-258021-xhx74vr6 167 104 to to IN cord-258021-xhx74vr6 167 105 Chlamydia Chlamydia NNP cord-258021-xhx74vr6 167 106 spp spp NNS cord-258021-xhx74vr6 167 107 . . . cord-258021-xhx74vr6 168 1 and and CC cord-258021-xhx74vr6 168 2 related relate VBN cord-258021-xhx74vr6 168 3 species specie NNS cord-258021-xhx74vr6 168 4 Oseltamivir Oseltamivir NNP cord-258021-xhx74vr6 168 5 overuse overuse NN cord-258021-xhx74vr6 168 6 at at IN cord-258021-xhx74vr6 168 7 a a DT cord-258021-xhx74vr6 168 8 Chicago Chicago NNP cord-258021-xhx74vr6 168 9 hospital hospital NN cord-258021-xhx74vr6 168 10 during during IN cord-258021-xhx74vr6 168 11 the the DT cord-258021-xhx74vr6 168 12 2009 2009 CD cord-258021-xhx74vr6 168 13 influenza influenza NN cord-258021-xhx74vr6 168 14 pandemic pandemic NN cord-258021-xhx74vr6 168 15 and and CC cord-258021-xhx74vr6 168 16 the the DT cord-258021-xhx74vr6 168 17 poor poor JJ cord-258021-xhx74vr6 168 18 predictive predictive JJ cord-258021-xhx74vr6 168 19 value value NN cord-258021-xhx74vr6 168 20 of of IN cord-258021-xhx74vr6 168 21 influenza influenza NN cord-258021-xhx74vr6 168 22 - - HYPH cord-258021-xhx74vr6 168 23 like like JJ cord-258021-xhx74vr6 168 24 illness illness NN cord-258021-xhx74vr6 168 25 criteria criteria VBZ cord-258021-xhx74vr6 168 26 Detection detection NN cord-258021-xhx74vr6 168 27 of of IN cord-258021-xhx74vr6 168 28 2009 2009 CD cord-258021-xhx74vr6 168 29 pandemic pandemic NN cord-258021-xhx74vr6 168 30 influenza influenza NN cord-258021-xhx74vr6 168 31 A(H1N1 A(H1N1 NNP cord-258021-xhx74vr6 168 32 ) ) -RRB- cord-258021-xhx74vr6 169 1 virus virus NN cord-258021-xhx74vr6 169 2 Infection infection NN cord-258021-xhx74vr6 169 3 in in IN cord-258021-xhx74vr6 169 4 different different JJ cord-258021-xhx74vr6 169 5 age age NN cord-258021-xhx74vr6 169 6 groups group NNS cord-258021-xhx74vr6 169 7 by by IN cord-258021-xhx74vr6 169 8 using use VBG cord-258021-xhx74vr6 169 9 rapid rapid JJ cord-258021-xhx74vr6 169 10 influenza influenza NN cord-258021-xhx74vr6 169 11 diagnostic diagnostic JJ cord-258021-xhx74vr6 169 12 tests test NNS cord-258021-xhx74vr6 169 13 Evaluation Evaluation NNP cord-258021-xhx74vr6 169 14 of of IN cord-258021-xhx74vr6 169 15 indirect indirect JJ cord-258021-xhx74vr6 169 16 fluorescent fluorescent JJ cord-258021-xhx74vr6 169 17 antibody antibody NN cord-258021-xhx74vr6 169 18 assays assay NNS cord-258021-xhx74vr6 169 19 compared compare VBN cord-258021-xhx74vr6 169 20 to to IN cord-258021-xhx74vr6 169 21 rapid rapid JJ cord-258021-xhx74vr6 169 22 influenza influenza NN cord-258021-xhx74vr6 169 23 diagnostic diagnostic JJ cord-258021-xhx74vr6 169 24 tests test NNS cord-258021-xhx74vr6 169 25 for for IN cord-258021-xhx74vr6 169 26 the the DT cord-258021-xhx74vr6 169 27 detection detection NN cord-258021-xhx74vr6 169 28 of of IN cord-258021-xhx74vr6 169 29 pandemic pandemic NN cord-258021-xhx74vr6 169 30 influenza influenza NN cord-258021-xhx74vr6 169 31 A a NN cord-258021-xhx74vr6 170 1 ( ( -LRB- cord-258021-xhx74vr6 170 2 H1N1 H1N1 NNP cord-258021-xhx74vr6 170 3 ) ) -RRB- cord-258021-xhx74vr6 170 4 pdm09 pdm09 NFP cord-258021-xhx74vr6 170 5 Sensitivity sensitivity NN cord-258021-xhx74vr6 170 6 of of IN cord-258021-xhx74vr6 170 7 rapid rapid JJ cord-258021-xhx74vr6 170 8 influenza influenza NN cord-258021-xhx74vr6 170 9 antigen antigen NN cord-258021-xhx74vr6 170 10 tests test NNS cord-258021-xhx74vr6 170 11 in in IN cord-258021-xhx74vr6 170 12 the the DT cord-258021-xhx74vr6 170 13 diagnosis diagnosis NN cord-258021-xhx74vr6 170 14 of of IN cord-258021-xhx74vr6 170 15 pandemic pandemic NN cord-258021-xhx74vr6 170 16 ( ( -LRB- cord-258021-xhx74vr6 171 1 H1N1)2009 H1N1)2009 NNS cord-258021-xhx74vr6 171 2 compared compare VBN cord-258021-xhx74vr6 171 3 with with IN cord-258021-xhx74vr6 171 4 the the DT cord-258021-xhx74vr6 171 5 standard standard JJ cord-258021-xhx74vr6 171 6 rRT rRT NNP cord-258021-xhx74vr6 171 7 - - HYPH cord-258021-xhx74vr6 171 8 PCR pcr NN cord-258021-xhx74vr6 171 9 technique technique NN cord-258021-xhx74vr6 171 10 during during IN cord-258021-xhx74vr6 171 11 the the DT cord-258021-xhx74vr6 171 12 2009 2009 CD cord-258021-xhx74vr6 171 13 pandemic pandemic NN cord-258021-xhx74vr6 171 14 in in IN cord-258021-xhx74vr6 171 15 Turkey Turkey NNP cord-258021-xhx74vr6 171 16 Comparison Comparison NNP cord-258021-xhx74vr6 171 17 of of IN cord-258021-xhx74vr6 171 18 the the DT cord-258021-xhx74vr6 171 19 performance performance NN cord-258021-xhx74vr6 171 20 of of IN cord-258021-xhx74vr6 171 21 direct direct JJ cord-258021-xhx74vr6 171 22 fluorescent fluorescent JJ cord-258021-xhx74vr6 171 23 antibody antibody NN cord-258021-xhx74vr6 171 24 staining staining NN cord-258021-xhx74vr6 171 25 , , , cord-258021-xhx74vr6 171 26 a a DT cord-258021-xhx74vr6 171 27 point point NN cord-258021-xhx74vr6 171 28 - - HYPH cord-258021-xhx74vr6 171 29 of of IN cord-258021-xhx74vr6 171 30 - - HYPH cord-258021-xhx74vr6 171 31 care care NN cord-258021-xhx74vr6 171 32 rapid rapid JJ cord-258021-xhx74vr6 171 33 antigen antigen NN cord-258021-xhx74vr6 171 34 test test NN cord-258021-xhx74vr6 171 35 and and CC cord-258021-xhx74vr6 171 36 virus virus NN cord-258021-xhx74vr6 171 37 isolation isolation NN cord-258021-xhx74vr6 171 38 with with IN cord-258021-xhx74vr6 171 39 that that DT cord-258021-xhx74vr6 171 40 of of IN cord-258021-xhx74vr6 171 41 RT RT NNP cord-258021-xhx74vr6 171 42 - - HYPH cord-258021-xhx74vr6 171 43 PCR PCR NNP cord-258021-xhx74vr6 171 44 for for IN cord-258021-xhx74vr6 171 45 the the DT cord-258021-xhx74vr6 171 46 detection detection NN cord-258021-xhx74vr6 171 47 of of IN cord-258021-xhx74vr6 171 48 novel novel JJ cord-258021-xhx74vr6 171 49 2009 2009 CD cord-258021-xhx74vr6 171 50 influenza influenza NN cord-258021-xhx74vr6 171 51 A a NN cord-258021-xhx74vr6 171 52 ( ( -LRB- cord-258021-xhx74vr6 171 53 H1N1 H1N1 NNP cord-258021-xhx74vr6 171 54 ) ) -RRB- cord-258021-xhx74vr6 171 55 virus virus NN cord-258021-xhx74vr6 171 56 in in IN cord-258021-xhx74vr6 171 57 respiratory respiratory JJ cord-258021-xhx74vr6 171 58 specimens specimen NNS cord-258021-xhx74vr6 171 59 Accuracy accuracy NN cord-258021-xhx74vr6 171 60 of of IN cord-258021-xhx74vr6 171 61 rapid rapid JJ cord-258021-xhx74vr6 171 62 influenza influenza NN cord-258021-xhx74vr6 171 63 diagnostic diagnostic JJ cord-258021-xhx74vr6 171 64 tests test NNS cord-258021-xhx74vr6 171 65 : : : cord-258021-xhx74vr6 171 66 a a DT cord-258021-xhx74vr6 171 67 meta meta JJ cord-258021-xhx74vr6 171 68 - - HYPH cord-258021-xhx74vr6 171 69 analysis analysis NN cord-258021-xhx74vr6 171 70 Randomised Randomised NNP cord-258021-xhx74vr6 171 71 controlled control VBN cord-258021-xhx74vr6 171 72 trial trial NN cord-258021-xhx74vr6 171 73 and and CC cord-258021-xhx74vr6 171 74 health health NN cord-258021-xhx74vr6 171 75 economic economic JJ cord-258021-xhx74vr6 171 76 evaluation evaluation NN cord-258021-xhx74vr6 171 77 of of IN cord-258021-xhx74vr6 171 78 the the DT cord-258021-xhx74vr6 171 79 impact impact NN cord-258021-xhx74vr6 171 80 of of IN cord-258021-xhx74vr6 171 81 diagnostic diagnostic JJ cord-258021-xhx74vr6 171 82 testing testing NN cord-258021-xhx74vr6 171 83 for for IN cord-258021-xhx74vr6 171 84 influenza influenza NN cord-258021-xhx74vr6 171 85 , , , cord-258021-xhx74vr6 171 86 respiratory respiratory JJ cord-258021-xhx74vr6 171 87 syncytial syncytial JJ cord-258021-xhx74vr6 171 88 virus virus NN cord-258021-xhx74vr6 171 89 and and CC cord-258021-xhx74vr6 171 90 Streptococcus streptococcus NN cord-258021-xhx74vr6 171 91 pneumoniae pneumoniae NN cord-258021-xhx74vr6 171 92 infection infection NN cord-258021-xhx74vr6 171 93 on on IN cord-258021-xhx74vr6 171 94 the the DT cord-258021-xhx74vr6 171 95 management management NN cord-258021-xhx74vr6 171 96 of of IN cord-258021-xhx74vr6 171 97 acute acute JJ cord-258021-xhx74vr6 171 98 admissions admission NNS cord-258021-xhx74vr6 171 99 in in IN cord-258021-xhx74vr6 171 100 the the DT cord-258021-xhx74vr6 171 101 elderly elderly JJ cord-258021-xhx74vr6 171 102 and and CC cord-258021-xhx74vr6 171 103 high high JJ cord-258021-xhx74vr6 171 104 - - HYPH cord-258021-xhx74vr6 171 105 risk risk NN cord-258021-xhx74vr6 172 1 18-to 18-to CD cord-258021-xhx74vr6 172 2 64-year 64-year JJ cord-258021-xhx74vr6 172 3 - - HYPH cord-258021-xhx74vr6 172 4 olds old NNS cord-258021-xhx74vr6 172 5 Performance performance NN cord-258021-xhx74vr6 172 6 of of IN cord-258021-xhx74vr6 172 7 rapid rapid JJ cord-258021-xhx74vr6 172 8 influenza influenza NN cord-258021-xhx74vr6 172 9 diagnostic diagnostic JJ cord-258021-xhx74vr6 172 10 testing testing NN cord-258021-xhx74vr6 172 11 in in IN cord-258021-xhx74vr6 172 12 outbreak outbreak NN cord-258021-xhx74vr6 172 13 settings setting NNS cord-258021-xhx74vr6 172 14 Evaluation Evaluation NNP cord-258021-xhx74vr6 172 15 of of IN cord-258021-xhx74vr6 172 16 3 3 CD cord-258021-xhx74vr6 172 17 rapid rapid JJ cord-258021-xhx74vr6 172 18 influenza influenza NN cord-258021-xhx74vr6 172 19 diagnostic diagnostic JJ cord-258021-xhx74vr6 172 20 tests test NNS cord-258021-xhx74vr6 172 21 during during IN cord-258021-xhx74vr6 172 22 the the DT cord-258021-xhx74vr6 172 23 2012 2012 CD cord-258021-xhx74vr6 172 24 - - SYM cord-258021-xhx74vr6 172 25 2013 2013 CD cord-258021-xhx74vr6 172 26 epidemic epidemic NN cord-258021-xhx74vr6 172 27 : : : cord-258021-xhx74vr6 172 28 influences influence NNS cord-258021-xhx74vr6 172 29 of of IN cord-258021-xhx74vr6 172 30 subtype subtype NN cord-258021-xhx74vr6 172 31 and and CC cord-258021-xhx74vr6 172 32 viral viral JJ cord-258021-xhx74vr6 172 33 load load NN cord-258021-xhx74vr6 172 34 Comparison comparison NN cord-258021-xhx74vr6 172 35 of of IN cord-258021-xhx74vr6 172 36 two two CD cord-258021-xhx74vr6 172 37 new new JJ cord-258021-xhx74vr6 172 38 generation generation NN cord-258021-xhx74vr6 172 39 influenza influenza NN cord-258021-xhx74vr6 172 40 rapid rapid JJ cord-258021-xhx74vr6 172 41 diagnostic diagnostic JJ cord-258021-xhx74vr6 172 42 tests test NNS cord-258021-xhx74vr6 172 43 with with IN cord-258021-xhx74vr6 172 44 instrument instrument NN cord-258021-xhx74vr6 172 45 - - HYPH cord-258021-xhx74vr6 172 46 based base VBN cord-258021-xhx74vr6 172 47 digital digital JJ cord-258021-xhx74vr6 172 48 readout readout NN cord-258021-xhx74vr6 172 49 systems system NNS cord-258021-xhx74vr6 172 50 for for IN cord-258021-xhx74vr6 172 51 influenza influenza NN cord-258021-xhx74vr6 172 52 virus virus NN cord-258021-xhx74vr6 172 53 detection detection NN cord-258021-xhx74vr6 172 54 Current current JJ cord-258021-xhx74vr6 172 55 approaches approach NNS cord-258021-xhx74vr6 172 56 for for IN cord-258021-xhx74vr6 172 57 diagnosis diagnosis NN cord-258021-xhx74vr6 172 58 of of IN cord-258021-xhx74vr6 172 59 influenza influenza NN cord-258021-xhx74vr6 172 60 virus virus NN cord-258021-xhx74vr6 172 61 infections infection NNS cord-258021-xhx74vr6 172 62 in in IN cord-258021-xhx74vr6 172 63 humans human NNS cord-258021-xhx74vr6 173 1 Influenza Influenza NNP cord-258021-xhx74vr6 173 2 A a DT cord-258021-xhx74vr6 173 3 virus virus NN cord-258021-xhx74vr6 173 4 drift drift NN cord-258021-xhx74vr6 173 5 variants variant NNS cord-258021-xhx74vr6 173 6 reduced reduce VBD cord-258021-xhx74vr6 173 7 the the DT cord-258021-xhx74vr6 173 8 detection detection NN cord-258021-xhx74vr6 173 9 sensitivity sensitivity NN cord-258021-xhx74vr6 173 10 of of IN cord-258021-xhx74vr6 173 11 a a DT cord-258021-xhx74vr6 173 12 commercial commercial JJ cord-258021-xhx74vr6 173 13 multiplex multiplex NN cord-258021-xhx74vr6 173 14 nucleic nucleic JJ cord-258021-xhx74vr6 173 15 acid acid NN cord-258021-xhx74vr6 173 16 amplification amplification NN cord-258021-xhx74vr6 173 17 assay assay NN cord-258021-xhx74vr6 173 18 in in IN cord-258021-xhx74vr6 173 19 the the DT cord-258021-xhx74vr6 173 20 season season NN cord-258021-xhx74vr6 173 21 2014/15 2014/15 CD cord-258021-xhx74vr6 173 22 Xpert Xpert NNP cord-258021-xhx74vr6 173 23 Flu Flu NNP cord-258021-xhx74vr6 173 24 for for IN cord-258021-xhx74vr6 173 25 point point NN cord-258021-xhx74vr6 173 26 - - HYPH cord-258021-xhx74vr6 173 27 of of IN cord-258021-xhx74vr6 173 28 - - HYPH cord-258021-xhx74vr6 173 29 care care NN cord-258021-xhx74vr6 173 30 diagnosis diagnosis NN cord-258021-xhx74vr6 173 31 of of IN cord-258021-xhx74vr6 173 32 human human JJ cord-258021-xhx74vr6 173 33 influenza influenza NN cord-258021-xhx74vr6 173 34 in in IN cord-258021-xhx74vr6 173 35 industrialized industrialize VBN cord-258021-xhx74vr6 173 36 countries country NNS cord-258021-xhx74vr6 173 37 Xpert(R Xpert(R NNP cord-258021-xhx74vr6 173 38 ) ) -RRB- cord-258021-xhx74vr6 173 39 MTB MTB NNP cord-258021-xhx74vr6 173 40 / / SYM cord-258021-xhx74vr6 173 41 RIF RIF NNP cord-258021-xhx74vr6 173 42 assay assay NN cord-258021-xhx74vr6 173 43 for for IN cord-258021-xhx74vr6 173 44 pulmonary pulmonary JJ cord-258021-xhx74vr6 173 45 tuberculosis tuberculosis NN cord-258021-xhx74vr6 173 46 and and CC cord-258021-xhx74vr6 173 47 rifampicin rifampicin NN cord-258021-xhx74vr6 173 48 resistance resistance NN cord-258021-xhx74vr6 173 49 in in IN cord-258021-xhx74vr6 173 50 adults adult NNS cord-258021-xhx74vr6 173 51 Comparison Comparison NNP cord-258021-xhx74vr6 173 52 of of IN cord-258021-xhx74vr6 173 53 GeneXpert GeneXpert NNP cord-258021-xhx74vr6 173 54 FluA FluA NNP cord-258021-xhx74vr6 173 55 PCR PCR NNP cord-258021-xhx74vr6 173 56 to to TO cord-258021-xhx74vr6 173 57 direct direct VB cord-258021-xhx74vr6 173 58 fluorescent fluorescent JJ cord-258021-xhx74vr6 173 59 antibody antibody NN cord-258021-xhx74vr6 173 60 and and CC cord-258021-xhx74vr6 173 61 respiratory respiratory JJ cord-258021-xhx74vr6 173 62 viral viral JJ cord-258021-xhx74vr6 173 63 panel panel NN cord-258021-xhx74vr6 173 64 PCR PCR NNP cord-258021-xhx74vr6 173 65 assays assay NNS cord-258021-xhx74vr6 173 66 for for IN cord-258021-xhx74vr6 173 67 detection detection NN cord-258021-xhx74vr6 173 68 of of IN cord-258021-xhx74vr6 173 69 2009 2009 CD cord-258021-xhx74vr6 173 70 novel novel NN cord-258021-xhx74vr6 173 71 H1N1 H1N1 NNP cord-258021-xhx74vr6 173 72 influenza influenza NN cord-258021-xhx74vr6 173 73 virus virus NN cord-258021-xhx74vr6 173 74 Comparison comparison NN cord-258021-xhx74vr6 173 75 of of IN cord-258021-xhx74vr6 173 76 cepheid cepheid NNP cord-258021-xhx74vr6 173 77 xpert xpert NNP cord-258021-xhx74vr6 173 78 Flu Flu NNP cord-258021-xhx74vr6 173 79 / / SYM cord-258021-xhx74vr6 173 80 RSV RSV NNP cord-258021-xhx74vr6 173 81 XC XC NNP cord-258021-xhx74vr6 173 82 and and CC cord-258021-xhx74vr6 173 83 BioFire BioFire NNP cord-258021-xhx74vr6 173 84 FilmArray FilmArray NNP cord-258021-xhx74vr6 173 85 for for IN cord-258021-xhx74vr6 173 86 detection detection NN cord-258021-xhx74vr6 173 87 of of IN cord-258021-xhx74vr6 173 88 influenza influenza NN cord-258021-xhx74vr6 173 89 A a NN cord-258021-xhx74vr6 173 90 , , , cord-258021-xhx74vr6 173 91 influenza influenza NN cord-258021-xhx74vr6 173 92 B b NN cord-258021-xhx74vr6 173 93 , , , cord-258021-xhx74vr6 173 94 and and CC cord-258021-xhx74vr6 173 95 respiratory respiratory JJ cord-258021-xhx74vr6 173 96 syncytial syncytial JJ cord-258021-xhx74vr6 173 97 virus virus NN cord-258021-xhx74vr6 173 98 Performance performance NN cord-258021-xhx74vr6 173 99 characteristics characteristic NNS cord-258021-xhx74vr6 173 100 of of IN cord-258021-xhx74vr6 173 101 xpert xpert NNP cord-258021-xhx74vr6 173 102 Flu Flu NNP cord-258021-xhx74vr6 173 103 / / SYM cord-258021-xhx74vr6 173 104 RSV RSV NNP cord-258021-xhx74vr6 173 105 XC XC NNP cord-258021-xhx74vr6 173 106 assay assay NN cord-258021-xhx74vr6 173 107 Prospective prospective JJ cord-258021-xhx74vr6 173 108 and and CC cord-258021-xhx74vr6 173 109 retrospective retrospective JJ cord-258021-xhx74vr6 173 110 evaluation evaluation NN cord-258021-xhx74vr6 173 111 of of IN cord-258021-xhx74vr6 173 112 the the DT cord-258021-xhx74vr6 173 113 Cepheid Cepheid NNP cord-258021-xhx74vr6 173 114 Xpert(R xpert(r NN cord-258021-xhx74vr6 173 115 ) ) -RRB- cord-258021-xhx74vr6 174 1 Flu flu NN cord-258021-xhx74vr6 174 2 / / SYM cord-258021-xhx74vr6 174 3 RSV RSV NNP cord-258021-xhx74vr6 174 4 XC XC NNP cord-258021-xhx74vr6 174 5 assay assay NN cord-258021-xhx74vr6 174 6 for for IN cord-258021-xhx74vr6 174 7 rapid rapid JJ cord-258021-xhx74vr6 174 8 detection detection NN cord-258021-xhx74vr6 174 9 of of IN cord-258021-xhx74vr6 174 10 influenza influenza NN cord-258021-xhx74vr6 174 11 A a NN cord-258021-xhx74vr6 174 12 , , , cord-258021-xhx74vr6 174 13 influenza influenza NN cord-258021-xhx74vr6 174 14 B b NN cord-258021-xhx74vr6 174 15 , , , cord-258021-xhx74vr6 174 16 and and CC cord-258021-xhx74vr6 174 17 respiratory respiratory JJ cord-258021-xhx74vr6 174 18 syncytial syncytial JJ cord-258021-xhx74vr6 174 19 virus virus NN cord-258021-xhx74vr6 174 20 Comparison comparison NN cord-258021-xhx74vr6 174 21 of of IN cord-258021-xhx74vr6 174 22 Xpert Xpert NNP cord-258021-xhx74vr6 174 23 Flu Flu NNP cord-258021-xhx74vr6 174 24 rapid rapid JJ cord-258021-xhx74vr6 174 25 nucleic nucleic JJ cord-258021-xhx74vr6 174 26 acid acid NN cord-258021-xhx74vr6 174 27 testing testing NN cord-258021-xhx74vr6 174 28 with with IN cord-258021-xhx74vr6 174 29 rapid rapid JJ cord-258021-xhx74vr6 174 30 antigen antigen NN cord-258021-xhx74vr6 174 31 testing testing NN cord-258021-xhx74vr6 174 32 for for IN cord-258021-xhx74vr6 174 33 the the DT cord-258021-xhx74vr6 174 34 diagnosis diagnosis NN cord-258021-xhx74vr6 174 35 of of IN cord-258021-xhx74vr6 174 36 influenza influenza NN cord-258021-xhx74vr6 174 37 A a NN cord-258021-xhx74vr6 174 38 and and CC cord-258021-xhx74vr6 174 39 B B NNP cord-258021-xhx74vr6 174 40 Evaluation Evaluation NNP cord-258021-xhx74vr6 174 41 of of IN cord-258021-xhx74vr6 174 42 the the DT cord-258021-xhx74vr6 174 43 Xpert Xpert NNP cord-258021-xhx74vr6 174 44 Flu Flu NNP cord-258021-xhx74vr6 174 45 rapid rapid JJ cord-258021-xhx74vr6 174 46 PCR PCR NNP cord-258021-xhx74vr6 174 47 assay assay NN cord-258021-xhx74vr6 174 48 in in IN cord-258021-xhx74vr6 174 49 high high JJ cord-258021-xhx74vr6 174 50 - - HYPH cord-258021-xhx74vr6 174 51 risk risk NN cord-258021-xhx74vr6 174 52 emergency emergency NN cord-258021-xhx74vr6 174 53 department department NN cord-258021-xhx74vr6 174 54 patients patient NNS cord-258021-xhx74vr6 174 55 Economic economic JJ cord-258021-xhx74vr6 174 56 impact impact NN cord-258021-xhx74vr6 174 57 of of IN cord-258021-xhx74vr6 174 58 a a DT cord-258021-xhx74vr6 174 59 new new JJ cord-258021-xhx74vr6 174 60 rapid rapid JJ cord-258021-xhx74vr6 174 61 PCR PCR NNP cord-258021-xhx74vr6 174 62 assay assay NN cord-258021-xhx74vr6 174 63 for for IN cord-258021-xhx74vr6 174 64 detecting detect VBG cord-258021-xhx74vr6 174 65 influenza influenza NN cord-258021-xhx74vr6 174 66 virus virus NN cord-258021-xhx74vr6 174 67 in in IN cord-258021-xhx74vr6 174 68 an an DT cord-258021-xhx74vr6 174 69 emergency emergency NN cord-258021-xhx74vr6 174 70 department department NN cord-258021-xhx74vr6 174 71 and and CC cord-258021-xhx74vr6 174 72 hospitalized hospitalize VBD cord-258021-xhx74vr6 174 73 patients patient NNS cord-258021-xhx74vr6 174 74 Performance Performance NNP cord-258021-xhx74vr6 174 75 of of IN cord-258021-xhx74vr6 174 76 the the DT cord-258021-xhx74vr6 174 77 Alere Alere NNP cord-258021-xhx74vr6 175 1 i i PRP cord-258021-xhx74vr6 175 2 influenza influenza NN cord-258021-xhx74vr6 175 3 A&B A&B NNP cord-258021-xhx74vr6 175 4 assay assay NN cord-258021-xhx74vr6 175 5 and and CC cord-258021-xhx74vr6 175 6 mariPOC mariPOC VBD cord-258021-xhx74vr6 175 7 test test VB cord-258021-xhx74vr6 175 8 for for IN cord-258021-xhx74vr6 175 9 the the DT cord-258021-xhx74vr6 175 10 rapid rapid JJ cord-258021-xhx74vr6 175 11 detection detection NN cord-258021-xhx74vr6 175 12 of of IN cord-258021-xhx74vr6 175 13 influenza influenza NN cord-258021-xhx74vr6 175 14 A a NN cord-258021-xhx74vr6 175 15 and and CC cord-258021-xhx74vr6 175 16 B b NN cord-258021-xhx74vr6 175 17 viruses virus NNS cord-258021-xhx74vr6 175 18 Integrated integrate VBD cord-258021-xhx74vr6 175 19 microfluidic microfluidic JJ cord-258021-xhx74vr6 175 20 device device NN cord-258021-xhx74vr6 175 21 using use VBG cord-258021-xhx74vr6 175 22 a a DT cord-258021-xhx74vr6 175 23 single single JJ cord-258021-xhx74vr6 175 24 universal universal JJ cord-258021-xhx74vr6 175 25 aptamer aptamer NN cord-258021-xhx74vr6 175 26 to to TO cord-258021-xhx74vr6 175 27 detect detect VB cord-258021-xhx74vr6 175 28 multiple multiple JJ cord-258021-xhx74vr6 175 29 types type NNS cord-258021-xhx74vr6 175 30 of of IN cord-258021-xhx74vr6 175 31 influenza influenza NN cord-258021-xhx74vr6 175 32 viruses virus NNS cord-258021-xhx74vr6 175 33 Sensitive sensitive JJ cord-258021-xhx74vr6 175 34 detection detection NN cord-258021-xhx74vr6 175 35 of of IN cord-258021-xhx74vr6 175 36 influenza influenza NN cord-258021-xhx74vr6 175 37 viruses virus NNS cord-258021-xhx74vr6 175 38 with with IN cord-258021-xhx74vr6 175 39 Europium europium NN cord-258021-xhx74vr6 175 40 nanoparticles nanoparticle NNS cord-258021-xhx74vr6 175 41 on on IN cord-258021-xhx74vr6 175 42 an an DT cord-258021-xhx74vr6 175 43 epoxy epoxy NN cord-258021-xhx74vr6 175 44 silica silica NN cord-258021-xhx74vr6 175 45 sol sol NN cord-258021-xhx74vr6 175 46 - - HYPH cord-258021-xhx74vr6 175 47 gel gel NNP cord-258021-xhx74vr6 175 48 functionalized functionalize VBN cord-258021-xhx74vr6 175 49 polycarbonate polycarbonate NN cord-258021-xhx74vr6 175 50 - - HYPH cord-258021-xhx74vr6 175 51 polydimethylsiloxane polydimethylsiloxane NN cord-258021-xhx74vr6 175 52 hybrid hybrid NN cord-258021-xhx74vr6 175 53 microchip microchip NN cord-258021-xhx74vr6 175 54 HIRA HIRA NNP cord-258021-xhx74vr6 175 55 - - HYPH cord-258021-xhx74vr6 175 56 TAN TAN NNP cord-258021-xhx74vr6 175 57 : : : cord-258021-xhx74vr6 175 58 a a DT cord-258021-xhx74vr6 175 59 real real JJ cord-258021-xhx74vr6 175 60 - - HYPH cord-258021-xhx74vr6 175 61 time time NN cord-258021-xhx74vr6 175 62 PCR pcr NN cord-258021-xhx74vr6 175 63 - - HYPH cord-258021-xhx74vr6 175 64 based base VBN cord-258021-xhx74vr6 175 65 system system NN cord-258021-xhx74vr6 175 66 for for IN cord-258021-xhx74vr6 175 67 the the DT cord-258021-xhx74vr6 175 68 rapid rapid JJ cord-258021-xhx74vr6 175 69 identification identification NN cord-258021-xhx74vr6 175 70 of of IN cord-258021-xhx74vr6 175 71 causative causative JJ cord-258021-xhx74vr6 175 72 agents agent NNS cord-258021-xhx74vr6 175 73 in in IN cord-258021-xhx74vr6 175 74 pneumonia pneumonia NN cord-258021-xhx74vr6 175 75 Comparison comparison NN cord-258021-xhx74vr6 175 76 of of IN cord-258021-xhx74vr6 175 77 the the DT cord-258021-xhx74vr6 175 78 Idaho Idaho NNP cord-258021-xhx74vr6 175 79 Technology Technology NNP cord-258021-xhx74vr6 175 80 FilmArray FilmArray NNP cord-258021-xhx74vr6 175 81 system system NN cord-258021-xhx74vr6 175 82 to to IN cord-258021-xhx74vr6 175 83 real real JJ cord-258021-xhx74vr6 175 84 - - HYPH cord-258021-xhx74vr6 175 85 time time NN cord-258021-xhx74vr6 175 86 PCR pcr NN cord-258021-xhx74vr6 175 87 for for IN cord-258021-xhx74vr6 175 88 detection detection NN cord-258021-xhx74vr6 175 89 of of IN cord-258021-xhx74vr6 175 90 respiratory respiratory JJ cord-258021-xhx74vr6 175 91 pathogens pathogen NNS cord-258021-xhx74vr6 175 92 in in IN cord-258021-xhx74vr6 175 93 children child NNS cord-258021-xhx74vr6 175 94 Comparison Comparison NNP cord-258021-xhx74vr6 175 95 of of IN cord-258021-xhx74vr6 175 96 the the DT cord-258021-xhx74vr6 175 97 FilmArray FilmArray NNP cord-258021-xhx74vr6 175 98 assay assay NN cord-258021-xhx74vr6 175 99 and and CC cord-258021-xhx74vr6 175 100 in in IN cord-258021-xhx74vr6 175 101 - - HYPH cord-258021-xhx74vr6 175 102 house house NN cord-258021-xhx74vr6 175 103 real real JJ cord-258021-xhx74vr6 175 104 - - HYPH cord-258021-xhx74vr6 175 105 time time NN cord-258021-xhx74vr6 175 106 PCR PCR NNP cord-258021-xhx74vr6 175 107 for for IN cord-258021-xhx74vr6 175 108 detection detection NN cord-258021-xhx74vr6 175 109 of of IN cord-258021-xhx74vr6 175 110 respiratory respiratory JJ cord-258021-xhx74vr6 175 111 infection infection NN cord-258021-xhx74vr6 175 112 Impact impact NN cord-258021-xhx74vr6 175 113 of of IN cord-258021-xhx74vr6 175 114 early early JJ cord-258021-xhx74vr6 175 115 detection detection NN cord-258021-xhx74vr6 175 116 of of IN cord-258021-xhx74vr6 175 117 respiratory respiratory JJ cord-258021-xhx74vr6 175 118 viruses virus NNS cord-258021-xhx74vr6 175 119 by by IN cord-258021-xhx74vr6 175 120 multiplex multiplex NN cord-258021-xhx74vr6 175 121 PCR pcr NN cord-258021-xhx74vr6 175 122 assay assay NN cord-258021-xhx74vr6 175 123 on on IN cord-258021-xhx74vr6 175 124 clinical clinical JJ cord-258021-xhx74vr6 175 125 outcomes outcome NNS cord-258021-xhx74vr6 175 126 in in IN cord-258021-xhx74vr6 175 127 adult adult NN cord-258021-xhx74vr6 175 128 patients patient NNS cord-258021-xhx74vr6 176 1 The the DT cord-258021-xhx74vr6 176 2 potential potential NN cord-258021-xhx74vr6 176 3 of of IN cord-258021-xhx74vr6 176 4 molecular molecular JJ cord-258021-xhx74vr6 176 5 diagnostics diagnostic NNS cord-258021-xhx74vr6 176 6 and and CC cord-258021-xhx74vr6 176 7 serum serum NN cord-258021-xhx74vr6 176 8 procalcitonin procalcitonin NNS cord-258021-xhx74vr6 176 9 levels level NNS cord-258021-xhx74vr6 176 10 to to TO cord-258021-xhx74vr6 176 11 change change VB cord-258021-xhx74vr6 176 12 the the DT cord-258021-xhx74vr6 176 13 antibiotic antibiotic JJ cord-258021-xhx74vr6 176 14 management management NN cord-258021-xhx74vr6 176 15 of of IN cord-258021-xhx74vr6 176 16 community community NN cord-258021-xhx74vr6 176 17 - - HYPH cord-258021-xhx74vr6 176 18 acquired acquire VBN cord-258021-xhx74vr6 176 19 pneumonia pneumonia NN cord-258021-xhx74vr6 176 20 Evaluation Evaluation NNP cord-258021-xhx74vr6 176 21 of of IN cord-258021-xhx74vr6 176 22 Curetis Curetis NNP cord-258021-xhx74vr6 176 23 Unyvero Unyvero NNP cord-258021-xhx74vr6 176 24 , , , cord-258021-xhx74vr6 176 25 a a DT cord-258021-xhx74vr6 176 26 multiplex multiplex JJ cord-258021-xhx74vr6 176 27 PCR pcr NN cord-258021-xhx74vr6 176 28 - - HYPH cord-258021-xhx74vr6 176 29 based base VBN cord-258021-xhx74vr6 176 30 testing testing NN cord-258021-xhx74vr6 176 31 system system NN cord-258021-xhx74vr6 176 32 , , , cord-258021-xhx74vr6 176 33 for for IN cord-258021-xhx74vr6 176 34 rapid rapid JJ cord-258021-xhx74vr6 176 35 detection detection NN cord-258021-xhx74vr6 176 36 of of IN cord-258021-xhx74vr6 176 37 bacteria bacteria NNS cord-258021-xhx74vr6 176 38 and and CC cord-258021-xhx74vr6 176 39 antibiotic antibiotic JJ cord-258021-xhx74vr6 176 40 resistance resistance NN cord-258021-xhx74vr6 176 41 and and CC cord-258021-xhx74vr6 176 42 impact impact NN cord-258021-xhx74vr6 176 43 of of IN cord-258021-xhx74vr6 176 44 the the DT cord-258021-xhx74vr6 176 45 assay assay NN cord-258021-xhx74vr6 176 46 on on IN cord-258021-xhx74vr6 176 47 management management NN cord-258021-xhx74vr6 176 48 of of IN cord-258021-xhx74vr6 176 49 severe severe JJ cord-258021-xhx74vr6 176 50 nosocomial nosocomial JJ cord-258021-xhx74vr6 176 51 pneumonia pneumonia NN cord-258021-xhx74vr6 176 52 Point point NN cord-258021-xhx74vr6 176 53 - - HYPH cord-258021-xhx74vr6 176 54 of of IN cord-258021-xhx74vr6 176 55 - - HYPH cord-258021-xhx74vr6 176 56 care care NN cord-258021-xhx74vr6 176 57 multiplex multiplex NN cord-258021-xhx74vr6 176 58 PCR PCR NNP cord-258021-xhx74vr6 176 59 promises promise VBZ cord-258021-xhx74vr6 176 60 short short JJ cord-258021-xhx74vr6 176 61 turnaround turnaround NN cord-258021-xhx74vr6 176 62 times time NNS cord-258021-xhx74vr6 176 63 for for IN cord-258021-xhx74vr6 176 64 microbial microbial JJ cord-258021-xhx74vr6 176 65 testing testing NN cord-258021-xhx74vr6 176 66 in in IN cord-258021-xhx74vr6 176 67 hospital hospital NN cord-258021-xhx74vr6 176 68 - - HYPH cord-258021-xhx74vr6 176 69 acquired acquire VBN cord-258021-xhx74vr6 176 70 pneumoniaan pneumoniaan NNP cord-258021-xhx74vr6 176 71 observational observational JJ cord-258021-xhx74vr6 176 72 pilot pilot NN cord-258021-xhx74vr6 176 73 study study NN cord-258021-xhx74vr6 176 74 in in IN cord-258021-xhx74vr6 176 75 critical critical JJ cord-258021-xhx74vr6 176 76 ill ill JJ cord-258021-xhx74vr6 176 77 patients patient NNS cord-258021-xhx74vr6 176 78 Evaluation Evaluation NNP cord-258021-xhx74vr6 176 79 of of IN cord-258021-xhx74vr6 176 80 a a DT cord-258021-xhx74vr6 176 81 polymerase polymerase NN cord-258021-xhx74vr6 176 82 chain chain NN cord-258021-xhx74vr6 176 83 reaction reaction NN cord-258021-xhx74vr6 176 84 - - HYPH cord-258021-xhx74vr6 176 85 electrospray electrospray JJ cord-258021-xhx74vr6 176 86 ionization ionization NN cord-258021-xhx74vr6 176 87 time time NN cord-258021-xhx74vr6 176 88 - - HYPH cord-258021-xhx74vr6 176 89 of of IN cord-258021-xhx74vr6 176 90 - - HYPH cord-258021-xhx74vr6 176 91 flight flight NN cord-258021-xhx74vr6 176 92 mass mass NN cord-258021-xhx74vr6 176 93 spectrometry spectrometry NN cord-258021-xhx74vr6 176 94 for for IN cord-258021-xhx74vr6 176 95 the the DT cord-258021-xhx74vr6 176 96 detection detection NN cord-258021-xhx74vr6 176 97 and and CC cord-258021-xhx74vr6 176 98 subtyping subtyping NN cord-258021-xhx74vr6 176 99 of of IN cord-258021-xhx74vr6 176 100 influenza influenza NN cord-258021-xhx74vr6 176 101 viruses virus NNS cord-258021-xhx74vr6 176 102 in in IN cord-258021-xhx74vr6 176 103 respiratory respiratory JJ cord-258021-xhx74vr6 176 104 specimens specimen NNS cord-258021-xhx74vr6 176 105 Viral viral JJ cord-258021-xhx74vr6 176 106 respiratory respiratory JJ cord-258021-xhx74vr6 176 107 tract tract NN cord-258021-xhx74vr6 176 108 infections infection NNS cord-258021-xhx74vr6 176 109 in in IN cord-258021-xhx74vr6 176 110 adult adult NN cord-258021-xhx74vr6 176 111 patients patient NNS cord-258021-xhx74vr6 176 112 attending attend VBG cord-258021-xhx74vr6 176 113 outpatient outpatient NN cord-258021-xhx74vr6 176 114 and and CC cord-258021-xhx74vr6 176 115 emergency emergency NN cord-258021-xhx74vr6 176 116 departments department NNS cord-258021-xhx74vr6 176 117 Rapid rapid JJ cord-258021-xhx74vr6 176 118 and and CC cord-258021-xhx74vr6 176 119 generic generic JJ cord-258021-xhx74vr6 176 120 identification identification NN cord-258021-xhx74vr6 176 121 of of IN cord-258021-xhx74vr6 176 122 influenza influenza NN cord-258021-xhx74vr6 176 123 A a NN cord-258021-xhx74vr6 176 124 and and CC cord-258021-xhx74vr6 176 125 other other JJ cord-258021-xhx74vr6 176 126 respiratory respiratory JJ cord-258021-xhx74vr6 176 127 viruses virus NNS cord-258021-xhx74vr6 176 128 with with IN cord-258021-xhx74vr6 176 129 mass mass NN cord-258021-xhx74vr6 176 130 spectrometry spectrometry NN cord-258021-xhx74vr6 176 131 Direct direct JJ cord-258021-xhx74vr6 176 132 identification identification NN cord-258021-xhx74vr6 176 133 of of IN cord-258021-xhx74vr6 176 134 bacteria bacteria NNS cord-258021-xhx74vr6 176 135 in in IN cord-258021-xhx74vr6 176 136 positive positive JJ cord-258021-xhx74vr6 176 137 blood blood NN cord-258021-xhx74vr6 176 138 culture culture NN cord-258021-xhx74vr6 176 139 bottles bottle NNS cord-258021-xhx74vr6 176 140 by by IN cord-258021-xhx74vr6 176 141 matrix matrix NN cord-258021-xhx74vr6 176 142 - - HYPH cord-258021-xhx74vr6 176 143 assisted assist VBN cord-258021-xhx74vr6 176 144 laser laser NN cord-258021-xhx74vr6 176 145 desorption desorption NN cord-258021-xhx74vr6 176 146 ionisation ionisation NN cord-258021-xhx74vr6 176 147 time time NN cord-258021-xhx74vr6 176 148 - - HYPH cord-258021-xhx74vr6 176 149 of of IN cord-258021-xhx74vr6 176 150 - - HYPH cord-258021-xhx74vr6 176 151 flight flight NN cord-258021-xhx74vr6 176 152 mass mass NN cord-258021-xhx74vr6 176 153 spectrometry spectrometry NN