id	sid	tid	token	lemma	pos
cord-263277-m4too6ob	1	1	key	key	NN
cord-263277-m4too6ob	1	2	:	:	:
cord-263277-m4too6ob	1	3	cord-263277-m4too6ob	cord-263277-m4too6ob	NNS
cord-263277-m4too6ob	1	4	authors	author	NNS
cord-263277-m4too6ob	1	5	:	:	:
cord-263277-m4too6ob	1	6	Guzmán	Guzmán	NNP
cord-263277-m4too6ob	1	7	,	,	,
cord-263277-m4too6ob	1	8	Carlos	Carlos	NNP
cord-263277-m4too6ob	1	9	Alberto	Alberto	NNP
cord-263277-m4too6ob	1	10	title	title	NN
cord-263277-m4too6ob	1	11	:	:	:
cord-263277-m4too6ob	1	12	Next	next	JJ
cord-263277-m4too6ob	1	13	Generation	Generation	NNP
cord-263277-m4too6ob	1	14	Influenza	Influenza	NNP
cord-263277-m4too6ob	1	15	Vaccines	Vaccines	NNPS
cord-263277-m4too6ob	1	16	:	:	:
cord-263277-m4too6ob	2	1	Looking	look	VBG
cord-263277-m4too6ob	2	2	into	into	IN
cord-263277-m4too6ob	2	3	the	the	DT
cord-263277-m4too6ob	2	4	Crystal	Crystal	NNP
cord-263277-m4too6ob	2	5	Ball	Ball	NNP
cord-263277-m4too6ob	2	6	date	date	NN
cord-263277-m4too6ob	2	7	:	:	:
cord-263277-m4too6ob	2	8	2020	2020	CD
cord-263277-m4too6ob	2	9	-	-	HYPH
cord-263277-m4too6ob	2	10	08	08	CD
cord-263277-m4too6ob	2	11	-	-	SYM
cord-263277-m4too6ob	2	12	21	21	CD
cord-263277-m4too6ob	2	13	journal	journal	NN
cord-263277-m4too6ob	2	14	:	:	:
cord-263277-m4too6ob	3	1	Vaccines	vaccine	NNS
cord-263277-m4too6ob	3	2	(	(	-LRB-
cord-263277-m4too6ob	3	3	Basel	Basel	NNP
cord-263277-m4too6ob	3	4	)	)	-RRB-
cord-263277-m4too6ob	3	5	DOI	DOI	NNP
cord-263277-m4too6ob	3	6	:	:	:
cord-263277-m4too6ob	4	1	10.3390	10.3390	CD
cord-263277-m4too6ob	4	2	/	/	SYM
cord-263277-m4too6ob	4	3	vaccines8030464	vaccines8030464	NNP
cord-263277-m4too6ob	4	4	sha	sha	NNP
cord-263277-m4too6ob	4	5	:	:	:
cord-263277-m4too6ob	5	1	0b7e355cb36f5f0639bd30f7c6bf730df79d0409	0b7e355cb36f5f0639bd30f7c6bf730df79d0409	CD
cord-263277-m4too6ob	6	1	doc_id	doc_id	CD
cord-263277-m4too6ob	7	1	:	:	:
cord-263277-m4too6ob	7	2	263277	263277	CD
cord-263277-m4too6ob	7	3	cord_uid	cord_uid	NNS
cord-263277-m4too6ob	7	4	:	:	:
cord-263277-m4too6ob	8	1	m4too6ob	m4too6ob	NNP
cord-263277-m4too6ob	8	2	Influenza	Influenza	NNP
cord-263277-m4too6ob	8	3	infections	infection	NNS
cord-263277-m4too6ob	8	4	are	be	VBP
cord-263277-m4too6ob	8	5	responsible	responsible	JJ
cord-263277-m4too6ob	8	6	for	for	IN
cord-263277-m4too6ob	8	7	significant	significant	JJ
cord-263277-m4too6ob	8	8	number	number	NN
cord-263277-m4too6ob	8	9	of	of	IN
cord-263277-m4too6ob	8	10	deaths	death	NNS
cord-263277-m4too6ob	8	11	and	and	CC
cord-263277-m4too6ob	8	12	overwhelming	overwhelming	JJ
cord-263277-m4too6ob	8	13	costs	cost	NNS
cord-263277-m4too6ob	8	14	worldwide	worldwide	RB
cord-263277-m4too6ob	8	15	every	every	DT
cord-263277-m4too6ob	8	16	year	year	NN
cord-263277-m4too6ob	8	17	.	.	.
cord-263277-m4too6ob	9	1	Vaccination	vaccination	NN
cord-263277-m4too6ob	9	2	represents	represent	VBZ
cord-263277-m4too6ob	9	3	the	the	DT
cord-263277-m4too6ob	9	4	only	only	JJ
cord-263277-m4too6ob	9	5	cost	cost	NN
cord-263277-m4too6ob	9	6	-	-	HYPH
cord-263277-m4too6ob	9	7	efficient	efficient	JJ
cord-263277-m4too6ob	9	8	alternative	alternative	NN
cord-263277-m4too6ob	9	9	to	to	TO
cord-263277-m4too6ob	9	10	address	address	VB
cord-263277-m4too6ob	9	11	this	this	DT
cord-263277-m4too6ob	9	12	major	major	JJ
cord-263277-m4too6ob	9	13	problem	problem	NN
cord-263277-m4too6ob	9	14	in	in	IN
cord-263277-m4too6ob	9	15	human	human	JJ
cord-263277-m4too6ob	9	16	health	health	NN
cord-263277-m4too6ob	9	17	.	.	.
cord-263277-m4too6ob	10	1	However	however	RB
cord-263277-m4too6ob	10	2	,	,	,
cord-263277-m4too6ob	10	3	current	current	JJ
cord-263277-m4too6ob	10	4	vaccines	vaccine	NNS
cord-263277-m4too6ob	10	5	are	be	VBP
cord-263277-m4too6ob	10	6	fraught	fraught	JJ
cord-263277-m4too6ob	10	7	by	by	IN
cord-263277-m4too6ob	10	8	many	many	JJ
cord-263277-m4too6ob	10	9	limitations	limitation	NNS
cord-263277-m4too6ob	10	10	,	,	,
cord-263277-m4too6ob	10	11	being	be	VBG
cord-263277-m4too6ob	10	12	far	far	RB
cord-263277-m4too6ob	10	13	from	from	IN
cord-263277-m4too6ob	10	14	optimal	optimal	JJ
cord-263277-m4too6ob	10	15	.	.	.
cord-263277-m4too6ob	11	1	Among	among	IN
cord-263277-m4too6ob	11	2	them	-PRON-	PRP
cord-263277-m4too6ob	11	3	,	,	,
cord-263277-m4too6ob	11	4	the	the	DT
cord-263277-m4too6ob	11	5	need	need	NN
cord-263277-m4too6ob	11	6	to	to	TO
cord-263277-m4too6ob	11	7	upgrade	upgrade	VB
cord-263277-m4too6ob	11	8	vaccines	vaccine	NNS
cord-263277-m4too6ob	11	9	every	every	DT
cord-263277-m4too6ob	11	10	year	year	NN
cord-263277-m4too6ob	11	11	through	through	IN
cord-263277-m4too6ob	11	12	a	a	DT
cord-263277-m4too6ob	11	13	time	time	NN
cord-263277-m4too6ob	11	14	-	-	HYPH
cord-263277-m4too6ob	11	15	consuming	consume	VBG
cord-263277-m4too6ob	11	16	process	process	NN
cord-263277-m4too6ob	11	17	open	open	JJ
cord-263277-m4too6ob	11	18	to	to	IN
cord-263277-m4too6ob	11	19	different	different	JJ
cord-263277-m4too6ob	11	20	caveats	caveat	NNS
cord-263277-m4too6ob	11	21	,	,	,
cord-263277-m4too6ob	11	22	and	and	CC
cord-263277-m4too6ob	11	23	the	the	DT
cord-263277-m4too6ob	11	24	critical	critical	JJ
cord-263277-m4too6ob	11	25	fact	fact	NN
cord-263277-m4too6ob	11	26	that	that	IN
cord-263277-m4too6ob	11	27	they	-PRON-	PRP
cord-263277-m4too6ob	11	28	exhibit	exhibit	VBP
cord-263277-m4too6ob	11	29	poorer	poor	JJR
cord-263277-m4too6ob	11	30	efficacy	efficacy	NN
cord-263277-m4too6ob	11	31	in	in	IN
cord-263277-m4too6ob	11	32	individuals	individual	NNS
cord-263277-m4too6ob	11	33	who	who	WP
cord-263277-m4too6ob	11	34	are	be	VBP
cord-263277-m4too6ob	11	35	at	at	IN
cord-263277-m4too6ob	11	36	high	high	JJ
cord-263277-m4too6ob	11	37	risk	risk	NN
cord-263277-m4too6ob	11	38	for	for	IN
cord-263277-m4too6ob	11	39	severe	severe	JJ
cord-263277-m4too6ob	11	40	infections	infection	NNS
cord-263277-m4too6ob	11	41	.	.	.
cord-263277-m4too6ob	12	1	Where	where	WRB
cord-263277-m4too6ob	12	2	are	be	VBP
cord-263277-m4too6ob	12	3	we	-PRON-	PRP
cord-263277-m4too6ob	12	4	?	?	.
cord-263277-m4too6ob	13	1	How	how	WRB
cord-263277-m4too6ob	13	2	can	can	MD
cord-263277-m4too6ob	13	3	knowledge	knowledge	VB
cord-263277-m4too6ob	13	4	and	and	CC
cord-263277-m4too6ob	13	5	technologies	technology	NNS
cord-263277-m4too6ob	13	6	contribute	contribute	VBP
cord-263277-m4too6ob	13	7	towards	towards	IN
cord-263277-m4too6ob	13	8	removing	remove	VBG
cord-263277-m4too6ob	13	9	current	current	JJ
cord-263277-m4too6ob	13	10	roadblocks	roadblock	NNS
cord-263277-m4too6ob	13	11	?	?	.
cord-263277-m4too6ob	14	1	What	what	WP
cord-263277-m4too6ob	14	2	does	do	VBZ
cord-263277-m4too6ob	14	3	the	the	DT
cord-263277-m4too6ob	14	4	future	future	JJ
cord-263277-m4too6ob	14	5	offer	offer	NN
cord-263277-m4too6ob	14	6	in	in	IN
cord-263277-m4too6ob	14	7	terms	term	NNS
cord-263277-m4too6ob	14	8	of	of	IN
cord-263277-m4too6ob	14	9	next	next	JJ
cord-263277-m4too6ob	14	10	generation	generation	NN
cord-263277-m4too6ob	14	11	vaccines	vaccine	NNS
cord-263277-m4too6ob	14	12	?	?	.
cord-263277-m4too6ob	15	1	seasons	season	NNS
cord-263277-m4too6ob	15	2	.	.	.
cord-263277-m4too6ob	16	1	On	on	IN
cord-263277-m4too6ob	16	2	the	the	DT
cord-263277-m4too6ob	16	3	other	other	JJ
cord-263277-m4too6ob	16	4	hand	hand	NN
cord-263277-m4too6ob	16	5	,	,	,
cord-263277-m4too6ob	16	6	they	-PRON-	PRP
cord-263277-m4too6ob	16	7	presented	present	VBD
cord-263277-m4too6ob	16	8	the	the	DT
cord-263277-m4too6ob	16	9	pros	pro	NNS
cord-263277-m4too6ob	16	10	and	and	CC
cord-263277-m4too6ob	16	11	cons	con	NNS
cord-263277-m4too6ob	16	12	of	of	IN
cord-263277-m4too6ob	16	13	protein	protein	NN
cord-263277-m4too6ob	16	14	-	-	HYPH
cord-263277-m4too6ob	16	15	based	base	VBN
cord-263277-m4too6ob	16	16	vaccines	vaccine	NNS
cord-263277-m4too6ob	16	17	produced	produce	VBN
cord-263277-m4too6ob	16	18	using	use	VBG
cord-263277-m4too6ob	16	19	a	a	DT
cord-263277-m4too6ob	16	20	Baculovirus	Baculovirus	NNP
cord-263277-m4too6ob	16	21	-	-	HYPH
cord-263277-m4too6ob	16	22	based	base	VBN
cord-263277-m4too6ob	16	23	approach	approach	NN
cord-263277-m4too6ob	16	24	,	,	,
cord-263277-m4too6ob	16	25	which	which	WDT
cord-263277-m4too6ob	16	26	eliminates	eliminate	VBZ
cord-263277-m4too6ob	16	27	the	the	DT
cord-263277-m4too6ob	16	28	constraints	constraint	NNS
cord-263277-m4too6ob	16	29	resulting	result	VBG
cord-263277-m4too6ob	16	30	from	from	IN
cord-263277-m4too6ob	16	31	relying	rely	VBG
cord-263277-m4too6ob	16	32	on	on	IN
cord-263277-m4too6ob	16	33	influenza	influenza	NN
cord-263277-m4too6ob	16	34	virus	virus	NN
cord-263277-m4too6ob	16	35	replication	replication	NN
cord-263277-m4too6ob	16	36	.	.	.
cord-263277-m4too6ob	17	1	Nevertheless	nevertheless	RB
cord-263277-m4too6ob	17	2	,	,	,
cord-263277-m4too6ob	17	3	practical	practical	JJ
cord-263277-m4too6ob	17	4	considerations	consideration	NNS
cord-263277-m4too6ob	17	5	,	,	,
cord-263277-m4too6ob	17	6	like	like	IN
cord-263277-m4too6ob	17	7	manufacturing	manufacturing	NN
cord-263277-m4too6ob	17	8	capacity	capacity	NN
cord-263277-m4too6ob	17	9	to	to	TO
cord-263277-m4too6ob	17	10	serve	serve	VB
cord-263277-m4too6ob	17	11	the	the	DT
cord-263277-m4too6ob	17	12	huge	huge	JJ
cord-263277-m4too6ob	17	13	demand	demand	NN
cord-263277-m4too6ob	17	14	for	for	IN
cord-263277-m4too6ob	17	15	influenza	influenza	NN
cord-263277-m4too6ob	17	16	vaccines	vaccine	NNS
cord-263277-m4too6ob	17	17	and	and	CC
cord-263277-m4too6ob	17	18	considerably	considerably	RB
cord-263277-m4too6ob	17	19	higher	high	JJR
cord-263277-m4too6ob	17	20	production	production	NN
cord-263277-m4too6ob	17	21	costs	cost	NNS
cord-263277-m4too6ob	17	22	still	still	RB
cord-263277-m4too6ob	17	23	represent	represent	VBP
cord-263277-m4too6ob	17	24	a	a	DT
cord-263277-m4too6ob	17	25	bottleneck	bottleneck	NN
cord-263277-m4too6ob	17	26	.	.	.
cord-263277-m4too6ob	18	1	In	in	IN
cord-263277-m4too6ob	18	2	their	-PRON-	PRP$
cord-263277-m4too6ob	18	3	review	review	NN
cord-263277-m4too6ob	18	4	article	article	NN
cord-263277-m4too6ob	18	5	,	,	,
cord-263277-m4too6ob	18	6	the	the	DT
cord-263277-m4too6ob	18	7	authors	author	NNS
cord-263277-m4too6ob	18	8	also	also	RB
cord-263277-m4too6ob	18	9	presented	present	VBD
cord-263277-m4too6ob	18	10	a	a	DT
cord-263277-m4too6ob	18	11	comprehensive	comprehensive	JJ
cord-263277-m4too6ob	18	12	summary	summary	NN
cord-263277-m4too6ob	18	13	of	of	IN
cord-263277-m4too6ob	18	14	the	the	DT
cord-263277-m4too6ob	18	15	current	current	JJ
cord-263277-m4too6ob	18	16	efforts	effort	NNS
cord-263277-m4too6ob	18	17	to	to	TO
cord-263277-m4too6ob	18	18	improve	improve	VB
cord-263277-m4too6ob	18	19	the	the	DT
cord-263277-m4too6ob	18	20	influenza	influenza	NN
cord-263277-m4too6ob	18	21	vaccines	vaccine	NNS
cord-263277-m4too6ob	18	22	produced	produce	VBN
cord-263277-m4too6ob	18	23	using	use	VBG
cord-263277-m4too6ob	18	24	standard	standard	JJ
cord-263277-m4too6ob	18	25	existing	exist	VBG
cord-263277-m4too6ob	18	26	technologies	technology	NNS
cord-263277-m4too6ob	18	27	.	.	.
cord-263277-m4too6ob	19	1	In	in	IN
cord-263277-m4too6ob	19	2	this	this	DT
cord-263277-m4too6ob	19	3	regard	regard	NN
cord-263277-m4too6ob	19	4	,	,	,
cord-263277-m4too6ob	19	5	the	the	DT
cord-263277-m4too6ob	19	6	use	use	NN
cord-263277-m4too6ob	19	7	of	of	IN
cord-263277-m4too6ob	19	8	adjuvants	adjuvant	NNS
cord-263277-m4too6ob	19	9	to	to	TO
cord-263277-m4too6ob	19	10	improve	improve	VB
cord-263277-m4too6ob	19	11	the	the	DT
cord-263277-m4too6ob	19	12	overall	overall	JJ
cord-263277-m4too6ob	19	13	efficacy	efficacy	NN
cord-263277-m4too6ob	19	14	of	of	IN
cord-263277-m4too6ob	19	15	vaccines	vaccine	NNS
cord-263277-m4too6ob	19	16	for	for	IN
cord-263277-m4too6ob	19	17	specific	specific	JJ
cord-263277-m4too6ob	19	18	subpopulation	subpopulation	NN
cord-263277-m4too6ob	19	19	groups	group	NNS
cord-263277-m4too6ob	19	20	is	be	VBZ
cord-263277-m4too6ob	19	21	discussed	discuss	VBN
cord-263277-m4too6ob	19	22	,	,	,
cord-263277-m4too6ob	19	23	as	as	RB
cord-263277-m4too6ob	19	24	well	well	RB
cord-263277-m4too6ob	19	25	as	as	IN
cord-263277-m4too6ob	19	26	the	the	DT
cord-263277-m4too6ob	19	27	exploitation	exploitation	NN
cord-263277-m4too6ob	19	28	of	of	IN
cord-263277-m4too6ob	19	29	nanotechnologies	nanotechnology	NNS
cord-263277-m4too6ob	19	30	to	to	TO
cord-263277-m4too6ob	19	31	increase	increase	VB
cord-263277-m4too6ob	19	32	the	the	DT
cord-263277-m4too6ob	19	33	immunogenicity	immunogenicity	NN
cord-263277-m4too6ob	19	34	of	of	IN
cord-263277-m4too6ob	19	35	protein	protein	NN
cord-263277-m4too6ob	19	36	-	-	HYPH
cord-263277-m4too6ob	19	37	based	base	VBN
cord-263277-m4too6ob	19	38	vaccines	vaccine	NNS
cord-263277-m4too6ob	19	39	.	.	.
cord-263277-m4too6ob	20	1	An	an	DT
cord-263277-m4too6ob	20	2	elegant	elegant	JJ
cord-263277-m4too6ob	20	3	approach	approach	NN
cord-263277-m4too6ob	20	4	enables	enable	VBZ
cord-263277-m4too6ob	20	5	the	the	DT
cord-263277-m4too6ob	20	6	engineering	engineering	NN
cord-263277-m4too6ob	20	7	of	of	IN
cord-263277-m4too6ob	20	8	recombinant	recombinant	JJ
cord-263277-m4too6ob	20	9	viruses	virus	NNS
cord-263277-m4too6ob	20	10	for	for	IN
cord-263277-m4too6ob	20	11	vaccine	vaccine	NN
cord-263277-m4too6ob	20	12	production	production	NN
cord-263277-m4too6ob	20	13	,	,	,
cord-263277-m4too6ob	20	14	which	which	WDT
cord-263277-m4too6ob	20	15	co	co	VBD
cord-263277-m4too6ob	20	16	-	-	NN
cord-263277-m4too6ob	20	17	expresses	express	VBZ
cord-263277-m4too6ob	20	18	the	the	DT
cord-263277-m4too6ob	20	19	vaccine	vaccine	NN
cord-263277-m4too6ob	20	20	relevant	relevant	JJ
cord-263277-m4too6ob	20	21	hemagglutinin	hemagglutinin	NN
cord-263277-m4too6ob	20	22	together	together	RB
cord-263277-m4too6ob	20	23	with	with	IN
cord-263277-m4too6ob	20	24	a	a	DT
cord-263277-m4too6ob	20	25	helper	helper	NN
cord-263277-m4too6ob	20	26	hemagglutinin	hemagglutinin	NN
cord-263277-m4too6ob	20	27	[	[	-LRB-
cord-263277-m4too6ob	20	28	10	10	CD
cord-263277-m4too6ob	20	29	]	]	-RRB-
cord-263277-m4too6ob	20	30	.	.	.
cord-263277-m4too6ob	21	1	This	this	DT
cord-263277-m4too6ob	21	2	strategy	strategy	NN
cord-263277-m4too6ob	21	3	prevents	prevent	VBZ
cord-263277-m4too6ob	21	4	the	the	DT
cord-263277-m4too6ob	21	5	emergence	emergence	NN
cord-263277-m4too6ob	21	6	of	of	IN
cord-263277-m4too6ob	21	7	egg	egg	NN
cord-263277-m4too6ob	21	8	-	-	HYPH
cord-263277-m4too6ob	21	9	adaptive	adaptive	JJ
cord-263277-m4too6ob	21	10	mutations	mutation	NNS
cord-263277-m4too6ob	21	11	and	and	CC
cord-263277-m4too6ob	21	12	reduces	reduce	VBZ
cord-263277-m4too6ob	21	13	the	the	DT
cord-263277-m4too6ob	21	14	overall	overall	JJ
cord-263277-m4too6ob	21	15	production	production	NN
cord-263277-m4too6ob	21	16	times	time	NNS
cord-263277-m4too6ob	21	17	.	.	.
cord-263277-m4too6ob	22	1	They	-PRON-	PRP
cord-263277-m4too6ob	22	2	also	also	RB
cord-263277-m4too6ob	22	3	address	address	VBP
cord-263277-m4too6ob	22	4	the	the	DT
cord-263277-m4too6ob	22	5	use	use	NN
cord-263277-m4too6ob	22	6	of	of	IN
cord-263277-m4too6ob	22	7	peptide	peptide	NN
cord-263277-m4too6ob	22	8	-	-	HYPH
cord-263277-m4too6ob	22	9	based	base	VBN
cord-263277-m4too6ob	22	10	vaccines	vaccine	NNS
cord-263277-m4too6ob	22	11	as	as	IN
cord-263277-m4too6ob	22	12	a	a	DT
cord-263277-m4too6ob	22	13	potential	potential	JJ
cord-263277-m4too6ob	22	14	alternative	alternative	NN
cord-263277-m4too6ob	22	15	.	.	.
cord-263277-m4too6ob	23	1	Although	although	IN
cord-263277-m4too6ob	23	2	promising	promise	VBG
cord-263277-m4too6ob	23	3	,	,	,
cord-263277-m4too6ob	23	4	the	the	DT
cord-263277-m4too6ob	23	5	presented	present	VBN
cord-263277-m4too6ob	23	6	drawbacks	drawback	NNS
cord-263277-m4too6ob	23	7	suggest	suggest	VBP
cord-263277-m4too6ob	23	8	that	that	IN
cord-263277-m4too6ob	23	9	considerable	considerable	JJ
cord-263277-m4too6ob	23	10	time	time	NN
cord-263277-m4too6ob	23	11	and	and	CC
cord-263277-m4too6ob	23	12	effort	effort	NN
cord-263277-m4too6ob	23	13	will	will	MD
cord-263277-m4too6ob	23	14	be	be	VB
cord-263277-m4too6ob	23	15	required	require	VBN
cord-263277-m4too6ob	23	16	to	to	TO
cord-263277-m4too6ob	23	17	make	make	VB
cord-263277-m4too6ob	23	18	it	-PRON-	PRP
cord-263277-m4too6ob	23	19	a	a	DT
cord-263277-m4too6ob	23	20	viable	viable	JJ
cord-263277-m4too6ob	23	21	approach	approach	NN
cord-263277-m4too6ob	23	22	for	for	IN
cord-263277-m4too6ob	23	23	implementation	implementation	NN
cord-263277-m4too6ob	23	24	in	in	IN
cord-263277-m4too6ob	23	25	the	the	DT
cord-263277-m4too6ob	23	26	influenza	influenza	NN
cord-263277-m4too6ob	23	27	vaccine	vaccine	NN
cord-263277-m4too6ob	23	28	field	field	NN
cord-263277-m4too6ob	23	29	.	.	.
cord-263277-m4too6ob	24	1	The	the	DT
cord-263277-m4too6ob	24	2	review	review	NN
cord-263277-m4too6ob	24	3	by	by	IN
cord-263277-m4too6ob	24	4	Clemens	Clemens	NNP
cord-263277-m4too6ob	24	5	et	et	NNP
cord-263277-m4too6ob	24	6	al	al	NNP
cord-263277-m4too6ob	24	7	.	.	.
cord-263277-m4too6ob	25	1	further	further	RB
cord-263277-m4too6ob	25	2	elaborates	elaborate	VBZ
cord-263277-m4too6ob	25	3	on	on	IN
cord-263277-m4too6ob	25	4	the	the	DT
cord-263277-m4too6ob	25	5	potential	potential	NN
cord-263277-m4too6ob	25	6	and	and	CC
cord-263277-m4too6ob	25	7	limitations	limitation	NNS
cord-263277-m4too6ob	25	8	of	of	IN
cord-263277-m4too6ob	25	9	harnessing	harness	VBG
cord-263277-m4too6ob	25	10	T	t	NN
cord-263277-m4too6ob	25	11	cells	cell	NNS
cord-263277-m4too6ob	25	12	for	for	IN
cord-263277-m4too6ob	25	13	the	the	DT
cord-263277-m4too6ob	25	14	development	development	NN
cord-263277-m4too6ob	25	15	of	of	IN
cord-263277-m4too6ob	25	16	influenza	influenza	NN
cord-263277-m4too6ob	25	17	vaccines	vaccine	NNS
cord-263277-m4too6ob	25	18	[	[	-LRB-
cord-263277-m4too6ob	25	19	11	11	CD
cord-263277-m4too6ob	25	20	]	]	-RRB-
cord-263277-m4too6ob	25	21	.	.	.
cord-263277-m4too6ob	26	1	In	in	IN
cord-263277-m4too6ob	26	2	this	this	DT
cord-263277-m4too6ob	26	3	particular	particular	JJ
cord-263277-m4too6ob	26	4	context	context	NN
cord-263277-m4too6ob	26	5	,	,	,
cord-263277-m4too6ob	26	6	animal	animal	NN
cord-263277-m4too6ob	26	7	studies	study	NNS
cord-263277-m4too6ob	26	8	support	support	VBP
cord-263277-m4too6ob	26	9	the	the	DT
cord-263277-m4too6ob	26	10	potential	potential	NN
cord-263277-m4too6ob	26	11	of	of	IN
cord-263277-m4too6ob	26	12	exploiting	exploit	VBG
cord-263277-m4too6ob	26	13	this	this	DT
cord-263277-m4too6ob	26	14	strategy	strategy	NN
cord-263277-m4too6ob	26	15	to	to	TO
cord-263277-m4too6ob	26	16	generate	generate	VB
cord-263277-m4too6ob	26	17	universal	universal	JJ
cord-263277-m4too6ob	26	18	or	or	CC
cord-263277-m4too6ob	26	19	at	at	IN
cord-263277-m4too6ob	26	20	least	least	JJS
cord-263277-m4too6ob	26	21	broader	broad	JJR
cord-263277-m4too6ob	26	22	next	next	JJ
cord-263277-m4too6ob	26	23	generation	generation	NN
cord-263277-m4too6ob	26	24	vaccines	vaccine	NNS
cord-263277-m4too6ob	26	25	providing	provide	VBG
cord-263277-m4too6ob	26	26	heterosubtypic	heterosubtypic	JJ
cord-263277-m4too6ob	26	27	protection	protection	NN
cord-263277-m4too6ob	26	28	by	by	IN
cord-263277-m4too6ob	26	29	stimulating	stimulate	VBG
cord-263277-m4too6ob	26	30	long	long	RB
cord-263277-m4too6ob	26	31	-	-	HYPH
cord-263277-m4too6ob	26	32	lasting	last	VBG
cord-263277-m4too6ob	26	33	T	T	NNP
cord-263277-m4too6ob	26	34	cell	cell	NN
cord-263277-m4too6ob	26	35	resident	resident	NN
cord-263277-m4too6ob	26	36	memory	memory	NN
cord-263277-m4too6ob	26	37	cells	cell	NNS
cord-263277-m4too6ob	26	38	.	.	.
cord-263277-m4too6ob	27	1	Nevertheless	nevertheless	RB
cord-263277-m4too6ob	27	2	,	,	,
cord-263277-m4too6ob	27	3	this	this	DT
cord-263277-m4too6ob	27	4	approach	approach	NN
cord-263277-m4too6ob	27	5	faces	face	VBZ
cord-263277-m4too6ob	27	6	several	several	JJ
cord-263277-m4too6ob	27	7	major	major	JJ
cord-263277-m4too6ob	27	8	constraints	constraint	NNS
cord-263277-m4too6ob	27	9	.	.	.
cord-263277-m4too6ob	28	1	As	as	IN
cord-263277-m4too6ob	28	2	described	describe	VBN
cord-263277-m4too6ob	28	3	in	in	IN
cord-263277-m4too6ob	28	4	the	the	DT
cord-263277-m4too6ob	28	5	review	review	NN
cord-263277-m4too6ob	28	6	,	,	,
cord-263277-m4too6ob	28	7	a	a	DT
cord-263277-m4too6ob	28	8	universal	universal	JJ
cord-263277-m4too6ob	28	9	vaccine	vaccine	NN
cord-263277-m4too6ob	28	10	based	base	VBN
cord-263277-m4too6ob	28	11	on	on	IN
cord-263277-m4too6ob	28	12	peptides	peptide	NNS
cord-263277-m4too6ob	28	13	should	should	MD
cord-263277-m4too6ob	28	14	mimic	mimic	VB
cord-263277-m4too6ob	28	15	more	more	RBR
cord-263277-m4too6ob	28	16	closely	closely	RB
cord-263277-m4too6ob	28	17	the	the	DT
cord-263277-m4too6ob	28	18	immune	immune	JJ
cord-263277-m4too6ob	28	19	responses	response	NNS
cord-263277-m4too6ob	28	20	observed	observe	VBN
cord-263277-m4too6ob	28	21	after	after	IN
cord-263277-m4too6ob	28	22	natural	natural	JJ
cord-263277-m4too6ob	28	23	infections	infection	NNS
cord-263277-m4too6ob	28	24	by	by	IN
cord-263277-m4too6ob	28	25	inducing	induce	VBG
cord-263277-m4too6ob	28	26	both	both	DT
cord-263277-m4too6ob	28	27	cross	cross	JJ
cord-263277-m4too6ob	28	28	-	-	JJ
cord-263277-m4too6ob	28	29	reactive	reactive	JJ
cord-263277-m4too6ob	28	30	peripheral	peripheral	JJ
cord-263277-m4too6ob	28	31	and	and	CC
cord-263277-m4too6ob	28	32	tissue	tissue	NN
cord-263277-m4too6ob	28	33	resident	resident	NN
cord-263277-m4too6ob	28	34	CD8	CD8	NNP
cord-263277-m4too6ob	28	35	T	T	NNP
cord-263277-m4too6ob	28	36	cells	cell	NNS
cord-263277-m4too6ob	28	37	in	in	IN
cord-263277-m4too6ob	28	38	addition	addition	NN
cord-263277-m4too6ob	28	39	to	to	TO
cord-263277-m4too6ob	28	40	cross	cross	VB
cord-263277-m4too6ob	28	41	-	-	JJ
cord-263277-m4too6ob	28	42	reactive	reactive	JJ
cord-263277-m4too6ob	28	43	antibodies	antibody	NNS
cord-263277-m4too6ob	28	44	and	and	CC
cord-263277-m4too6ob	28	45	CD4	CD4	NNP
cord-263277-m4too6ob	28	46	T	T	NNP
cord-263277-m4too6ob	28	47	follicular	follicular	NN
cord-263277-m4too6ob	28	48	and	and	CC
cord-263277-m4too6ob	28	49	helper	helper	NN
cord-263277-m4too6ob	28	50	cells	cell	NNS
cord-263277-m4too6ob	28	51	.	.	.
cord-263277-m4too6ob	29	1	However	however	RB
cord-263277-m4too6ob	29	2	,	,	,
cord-263277-m4too6ob	29	3	as	as	IN
cord-263277-m4too6ob	29	4	described	describe	VBN
cord-263277-m4too6ob	29	5	in	in	IN
cord-263277-m4too6ob	29	6	the	the	DT
cord-263277-m4too6ob	29	7	review	review	NN
cord-263277-m4too6ob	29	8	,	,	,
cord-263277-m4too6ob	29	9	special	special	JJ
cord-263277-m4too6ob	29	10	vaccination	vaccination	NN
cord-263277-m4too6ob	29	11	strategies	strategy	NNS
cord-263277-m4too6ob	29	12	will	will	MD
cord-263277-m4too6ob	29	13	be	be	VB
cord-263277-m4too6ob	29	14	needed	need	VBN
cord-263277-m4too6ob	29	15	to	to	TO
cord-263277-m4too6ob	29	16	promote	promote	VB
cord-263277-m4too6ob	29	17	the	the	DT
cord-263277-m4too6ob	29	18	seeding	seeding	NN
cord-263277-m4too6ob	29	19	of	of	IN
cord-263277-m4too6ob	29	20	tissue	tissue	NN
cord-263277-m4too6ob	29	21	resident	resident	JJ
cord-263277-m4too6ob	29	22	memory	memory	NN
cord-263277-m4too6ob	29	23	T	T	NNP
cord-263277-m4too6ob	29	24	cells	cell	NNS
cord-263277-m4too6ob	29	25	in	in	IN
cord-263277-m4too6ob	29	26	the	the	DT
cord-263277-m4too6ob	29	27	respiratory	respiratory	JJ
cord-263277-m4too6ob	29	28	tract	tract	NN
cord-263277-m4too6ob	29	29	and	and	CC
cord-263277-m4too6ob	29	30	prevent	prevent	VB
cord-263277-m4too6ob	29	31	their	-PRON-	PRP$
cord-263277-m4too6ob	29	32	attrition	attrition	NN
cord-263277-m4too6ob	29	33	.	.	.
cord-263277-m4too6ob	30	1	Furthermore	furthermore	RB
cord-263277-m4too6ob	30	2	,	,	,
cord-263277-m4too6ob	30	3	universal	universal	JJ
cord-263277-m4too6ob	30	4	protection	protection	NN
cord-263277-m4too6ob	30	5	will	will	MD
cord-263277-m4too6ob	30	6	require	require	VB
cord-263277-m4too6ob	30	7	addressing	address	VBG
cord-263277-m4too6ob	30	8	human	human	JJ
cord-263277-m4too6ob	30	9	leucocyte	leucocyte	NNP
cord-263277-m4too6ob	30	10	antigen	antigen	NN
cord-263277-m4too6ob	30	11	(	(	-LRB-
cord-263277-m4too6ob	30	12	HLA)-restriction	hla)-restriction	NN
cord-263277-m4too6ob	30	13	by	by	IN
cord-263277-m4too6ob	30	14	the	the	DT
cord-263277-m4too6ob	30	15	inclusion	inclusion	NN
cord-263277-m4too6ob	30	16	of	of	IN
cord-263277-m4too6ob	30	17	appropriate	appropriate	JJ
cord-263277-m4too6ob	30	18	peptides	peptide	NNS
cord-263277-m4too6ob	30	19	.	.	.
cord-263277-m4too6ob	31	1	Such	such	JJ
cord-263277-m4too6ob	31	2	vaccines	vaccine	NNS
cord-263277-m4too6ob	31	3	should	should	MD
cord-263277-m4too6ob	31	4	not	not	RB
cord-263277-m4too6ob	31	5	only	only	RB
cord-263277-m4too6ob	31	6	stimulate	stimulate	VB
cord-263277-m4too6ob	31	7	multiple	multiple	JJ
cord-263277-m4too6ob	31	8	cross	cross	JJ
cord-263277-m4too6ob	31	9	-	-	JJ
cord-263277-m4too6ob	31	10	reactive	reactive	JJ
cord-263277-m4too6ob	31	11	epitope	epitope	NN
cord-263277-m4too6ob	31	12	-	-	HYPH
cord-263277-m4too6ob	31	13	specific	specific	JJ
cord-263277-m4too6ob	31	14	T	t	NN
cord-263277-m4too6ob	31	15	cells	cell	NNS
cord-263277-m4too6ob	31	16	,	,	,
cord-263277-m4too6ob	31	17	but	but	CC
cord-263277-m4too6ob	31	18	also	also	RB
cord-263277-m4too6ob	31	19	encompass	encompass	VB
cord-263277-m4too6ob	31	20	epitopes	epitope	NNS
cord-263277-m4too6ob	31	21	recognized	recognize	VBN
cord-263277-m4too6ob	31	22	by	by	IN
cord-263277-m4too6ob	31	23	rare	rare	JJ
cord-263277-m4too6ob	31	24	HLA	HLA	NNP
cord-263277-m4too6ob	31	25	types	type	NNS
cord-263277-m4too6ob	31	26	from	from	IN
cord-263277-m4too6ob	31	27	minor	minor	JJ
cord-263277-m4too6ob	31	28	ethnicities	ethnicity	NNS
cord-263277-m4too6ob	31	29	.	.	.
cord-263277-m4too6ob	32	1	Finally	finally	RB
cord-263277-m4too6ob	32	2	,	,	,
cord-263277-m4too6ob	32	3	current	current	JJ
cord-263277-m4too6ob	32	4	influenza	influenza	NN
cord-263277-m4too6ob	32	5	vaccines	vaccine	NNS
cord-263277-m4too6ob	32	6	are	be	VBP
cord-263277-m4too6ob	32	7	approved	approve	VBN
cord-263277-m4too6ob	32	8	dependent	dependent	JJ
cord-263277-m4too6ob	32	9	on	on	IN
cord-263277-m4too6ob	32	10	the	the	DT
cord-263277-m4too6ob	32	11	accepted	accept	VBN
cord-263277-m4too6ob	32	12	correlates	correlate	NNS
cord-263277-m4too6ob	32	13	for	for	IN
cord-263277-m4too6ob	32	14	protection	protection	NN
cord-263277-m4too6ob	32	15	based	base	VBN
cord-263277-m4too6ob	32	16	on	on	IN
cord-263277-m4too6ob	32	17	the	the	DT
cord-263277-m4too6ob	32	18	stimulation	stimulation	NN
cord-263277-m4too6ob	32	19	of	of	IN
cord-263277-m4too6ob	32	20	functional	functional	JJ
cord-263277-m4too6ob	32	21	antibodies	antibody	NNS
cord-263277-m4too6ob	32	22	recognizing	recognize	VBG
cord-263277-m4too6ob	32	23	the	the	DT
cord-263277-m4too6ob	32	24	hemagglutinin	hemagglutinin	NN
cord-263277-m4too6ob	32	25	.	.	.
cord-263277-m4too6ob	33	1	Large	large	JJ
cord-263277-m4too6ob	33	2	-	-	HYPH
cord-263277-m4too6ob	33	3	scale	scale	NN
cord-263277-m4too6ob	33	4	clinical	clinical	JJ
cord-263277-m4too6ob	33	5	studies	study	NNS
cord-263277-m4too6ob	33	6	will	will	MD
cord-263277-m4too6ob	33	7	be	be	VB
cord-263277-m4too6ob	33	8	needed	need	VBN
cord-263277-m4too6ob	33	9	to	to	TO
cord-263277-m4too6ob	33	10	define	define	VB
cord-263277-m4too6ob	33	11	similar	similar	JJ
cord-263277-m4too6ob	33	12	robust	robust	JJ
cord-263277-m4too6ob	33	13	correlates	correlate	NNS
cord-263277-m4too6ob	33	14	for	for	IN
cord-263277-m4too6ob	33	15	a	a	DT
cord-263277-m4too6ob	33	16	conceptually	conceptually	RB
cord-263277-m4too6ob	33	17	novel	novel	JJ
cord-263277-m4too6ob	33	18	class	class	NN
cord-263277-m4too6ob	33	19	of	of	IN
cord-263277-m4too6ob	33	20	T	T	NNP
cord-263277-m4too6ob	33	21	cell	cell	NN
cord-263277-m4too6ob	33	22	influenza	influenza	NN
cord-263277-m4too6ob	33	23	vaccines	vaccine	NNS
cord-263277-m4too6ob	33	24	.	.	.
cord-263277-m4too6ob	34	1	New	new	JJ
cord-263277-m4too6ob	34	2	disruptive	disruptive	JJ
cord-263277-m4too6ob	34	3	technologies	technology	NNS
cord-263277-m4too6ob	34	4	,	,	,
cord-263277-m4too6ob	34	5	such	such	JJ
cord-263277-m4too6ob	34	6	as	as	IN
cord-263277-m4too6ob	34	7	the	the	DT
cord-263277-m4too6ob	34	8	use	use	NN
cord-263277-m4too6ob	34	9	of	of	IN
cord-263277-m4too6ob	34	10	nucleic	nucleic	JJ
cord-263277-m4too6ob	34	11	acid	acid	NN
cord-263277-m4too6ob	34	12	vaccines	vaccine	NNS
cord-263277-m4too6ob	34	13	(	(	-LRB-
cord-263277-m4too6ob	34	14	e.g.	e.g.	RB
cord-263277-m4too6ob	34	15	,	,	,
cord-263277-m4too6ob	34	16	DNA	DNA	NNP
cord-263277-m4too6ob	34	17	or	or	CC
cord-263277-m4too6ob	34	18	RNA	RNA	NNP
cord-263277-m4too6ob	34	19	)	)	-RRB-
cord-263277-m4too6ob	34	20	,	,	,
cord-263277-m4too6ob	34	21	which	which	WDT
cord-263277-m4too6ob	34	22	render	render	VBP
cord-263277-m4too6ob	34	23	unnecessary	unnecessary	JJ
cord-263277-m4too6ob	34	24	the	the	DT
cord-263277-m4too6ob	34	25	production	production	NN
cord-263277-m4too6ob	34	26	of	of	IN
cord-263277-m4too6ob	34	27	proteins	protein	NNS
cord-263277-m4too6ob	34	28	,	,	,
cord-263277-m4too6ob	34	29	can	can	MD
cord-263277-m4too6ob	34	30	be	be	VB
cord-263277-m4too6ob	34	31	also	also	RB
cord-263277-m4too6ob	34	32	exploited	exploit	VBN
cord-263277-m4too6ob	34	33	to	to	TO
cord-263277-m4too6ob	34	34	develop	develop	VB
cord-263277-m4too6ob	34	35	next	next	JJ
cord-263277-m4too6ob	34	36	generation	generation	NN
cord-263277-m4too6ob	34	37	influenza	influenza	NN
cord-263277-m4too6ob	34	38	vaccines	vaccine	NNS
cord-263277-m4too6ob	34	39	.	.	.
cord-263277-m4too6ob	35	1	In	in	IN
cord-263277-m4too6ob	35	2	this	this	DT
cord-263277-m4too6ob	35	3	regard	regard	NN
cord-263277-m4too6ob	35	4	,	,	,
cord-263277-m4too6ob	35	5	RNA	RNA	NNP
cord-263277-m4too6ob	35	6	vaccines	vaccine	NNS
cord-263277-m4too6ob	35	7	represent	represent	VBP
cord-263277-m4too6ob	35	8	a	a	DT
cord-263277-m4too6ob	35	9	cutting	cutting	JJ
cord-263277-m4too6ob	35	10	-	-	HYPH
cord-263277-m4too6ob	35	11	edge	edge	NN
cord-263277-m4too6ob	35	12	approach	approach	NN
cord-263277-m4too6ob	35	13	,	,	,
cord-263277-m4too6ob	35	14	which	which	WDT
cord-263277-m4too6ob	35	15	dramatically	dramatically	RB
cord-263277-m4too6ob	35	16	reduces	reduce	VBZ
cord-263277-m4too6ob	35	17	production	production	NN
cord-263277-m4too6ob	35	18	times	time	NNS
cord-263277-m4too6ob	35	19	,	,	,
cord-263277-m4too6ob	35	20	ensure	ensure	VB
cord-263277-m4too6ob	35	21	the	the	DT
cord-263277-m4too6ob	35	22	fidelity	fidelity	NN
cord-263277-m4too6ob	35	23	of	of	IN
cord-263277-m4too6ob	35	24	the	the	DT
cord-263277-m4too6ob	35	25	encoded	encode	VBN
cord-263277-m4too6ob	35	26	sequences	sequence	NNS
cord-263277-m4too6ob	35	27	,	,	,
cord-263277-m4too6ob	35	28	and	and	CC
cord-263277-m4too6ob	35	29	are	be	VBP
cord-263277-m4too6ob	35	30	insulated	insulate	VBN
cord-263277-m4too6ob	35	31	from	from	IN
cord-263277-m4too6ob	35	32	shortages	shortage	NNS
cord-263277-m4too6ob	35	33	of	of	IN
cord-263277-m4too6ob	35	34	eggs	egg	NNS
cord-263277-m4too6ob	35	35	or	or	CC
cord-263277-m4too6ob	35	36	the	the	DT
cord-263277-m4too6ob	35	37	constraints	constraint	NNS
cord-263277-m4too6ob	35	38	attached	attach	VBN
cord-263277-m4too6ob	35	39	to	to	IN
cord-263277-m4too6ob	35	40	cell	cell	NN
cord-263277-m4too6ob	35	41	factories	factory	NNS
cord-263277-m4too6ob	35	42	.	.	.
cord-263277-m4too6ob	36	1	This	this	DT
cord-263277-m4too6ob	36	2	renders	render	VBZ
cord-263277-m4too6ob	36	3	this	this	DT
cord-263277-m4too6ob	36	4	technology	technology	NN
cord-263277-m4too6ob	36	5	particularly	particularly	RB
cord-263277-m4too6ob	36	6	appealing	appeal	VBG
cord-263277-m4too6ob	36	7	for	for	IN
cord-263277-m4too6ob	36	8	potential	potential	JJ
cord-263277-m4too6ob	36	9	emerging	emerge	VBG
cord-263277-m4too6ob	36	10	influenza	influenza	NN
cord-263277-m4too6ob	36	11	pandemics	pandemic	NNS
cord-263277-m4too6ob	36	12	.	.	.
cord-263277-m4too6ob	37	1	Preclinical	preclinical	JJ
cord-263277-m4too6ob	37	2	studies	study	NNS
cord-263277-m4too6ob	37	3	in	in	IN
cord-263277-m4too6ob	37	4	different	different	JJ
cord-263277-m4too6ob	37	5	animal	animal	NN
cord-263277-m4too6ob	37	6	species	specie	NNS
cord-263277-m4too6ob	37	7	and	and	CC
cord-263277-m4too6ob	37	8	first	first	JJ
cord-263277-m4too6ob	37	9	-	-	HYPH
cord-263277-m4too6ob	37	10	in	in	IN
cord-263277-m4too6ob	37	11	-	-	HYPH
cord-263277-m4too6ob	37	12	man	man	NN
cord-263277-m4too6ob	37	13	studies	study	NNS
cord-263277-m4too6ob	37	14	also	also	RB
cord-263277-m4too6ob	37	15	demonstrated	demonstrate	VBD
cord-263277-m4too6ob	37	16	the	the	DT
cord-263277-m4too6ob	37	17	intrinsic	intrinsic	JJ
cord-263277-m4too6ob	37	18	value	value	NN
cord-263277-m4too6ob	37	19	of	of	IN
cord-263277-m4too6ob	37	20	this	this	DT
cord-263277-m4too6ob	37	21	approach	approach	NN
cord-263277-m4too6ob	37	22	[	[	-LRB-
cord-263277-m4too6ob	37	23	12	12	CD
cord-263277-m4too6ob	37	24	,	,	,
cord-263277-m4too6ob	37	25	13	13	CD
cord-263277-m4too6ob	37	26	]	]	-RRB-
cord-263277-m4too6ob	37	27	.	.	.
cord-263277-m4too6ob	38	1	However	however	RB
cord-263277-m4too6ob	38	2	,	,	,
cord-263277-m4too6ob	38	3	these	these	DT
cord-263277-m4too6ob	38	4	studies	study	NNS
cord-263277-m4too6ob	38	5	,	,	,
cord-263277-m4too6ob	38	6	as	as	RB
cord-263277-m4too6ob	38	7	well	well	RB
cord-263277-m4too6ob	38	8	as	as	IN
cord-263277-m4too6ob	38	9	some	some	DT
cord-263277-m4too6ob	38	10	of	of	IN
cord-263277-m4too6ob	38	11	the	the	DT
cord-263277-m4too6ob	38	12	trials	trial	NNS
cord-263277-m4too6ob	38	13	carried	carry	VBN
cord-263277-m4too6ob	38	14	out	out	RP
cord-263277-m4too6ob	38	15	in	in	IN
cord-263277-m4too6ob	38	16	the	the	DT
cord-263277-m4too6ob	38	17	context	context	NN
cord-263277-m4too6ob	38	18	of	of	IN
cord-263277-m4too6ob	38	19	the	the	DT
cord-263277-m4too6ob	38	20	COVID-19	covid-19	JJ
cord-263277-m4too6ob	38	21	pandemic	pandemic	NN
cord-263277-m4too6ob	38	22	[	[	-LRB-
cord-263277-m4too6ob	38	23	14	14	CD
cord-263277-m4too6ob	38	24	,	,	,
cord-263277-m4too6ob	38	25	15	15	CD
cord-263277-m4too6ob	38	26	]	]	-RRB-
cord-263277-m4too6ob	38	27	showed	show	VBD
cord-263277-m4too6ob	38	28	that	that	IN
cord-263277-m4too6ob	38	29	the	the	DT
cord-263277-m4too6ob	38	30	higher	high	JJR
cord-263277-m4too6ob	38	31	reactogenicity	reactogenicity	NN
cord-263277-m4too6ob	38	32	of	of	IN
cord-263277-m4too6ob	38	33	RNA	RNA	NNP
cord-263277-m4too6ob	38	34	vaccines	vaccine	NNS
cord-263277-m4too6ob	38	35	respect	respect	NN
cord-263277-m4too6ob	38	36	to	to	IN
cord-263277-m4too6ob	38	37	what	what	WP
cord-263277-m4too6ob	38	38	observed	observe	VBD
cord-263277-m4too6ob	38	39	for	for	IN
cord-263277-m4too6ob	38	40	influenza	influenza	NN
cord-263277-m4too6ob	38	41	vaccines	vaccine	NNS
cord-263277-m4too6ob	38	42	developed	develop	VBN
cord-263277-m4too6ob	38	43	using	use	VBG
cord-263277-m4too6ob	38	44	conventional	conventional	JJ
cord-263277-m4too6ob	38	45	standard	standard	JJ
cord-263277-m4too6ob	38	46	technologies	technology	NNS
cord-263277-m4too6ob	38	47	might	may	MD
cord-263277-m4too6ob	38	48	be	be	VB
cord-263277-m4too6ob	38	49	an	an	DT
cord-263277-m4too6ob	38	50	issue	issue	NN
cord-263277-m4too6ob	38	51	for	for	IN
cord-263277-m4too6ob	38	52	the	the	DT
cord-263277-m4too6ob	38	53	global	global	JJ
cord-263277-m4too6ob	38	54	acceptance	acceptance	NN
cord-263277-m4too6ob	38	55	of	of	IN
cord-263277-m4too6ob	38	56	an	an	DT
cord-263277-m4too6ob	38	57	RNA	RNA	NNP
cord-263277-m4too6ob	38	58	-	-	HYPH
cord-263277-m4too6ob	38	59	based	base	VBN
cord-263277-m4too6ob	38	60	prophylactic	prophylactic	JJ
cord-263277-m4too6ob	38	61	vaccine	vaccine	NN
cord-263277-m4too6ob	38	62	.	.	.
cord-263277-m4too6ob	39	1	In	in	IN
cord-263277-m4too6ob	39	2	the	the	DT
cord-263277-m4too6ob	39	3	review	review	NN
cord-263277-m4too6ob	39	4	by	by	IN
cord-263277-m4too6ob	39	5	Scorza	Scorza	NNP
cord-263277-m4too6ob	39	6	and	and	CC
cord-263277-m4too6ob	39	7	Pardi	Pardi	NNP
cord-263277-m4too6ob	39	8	,	,	,
cord-263277-m4too6ob	39	9	the	the	DT
cord-263277-m4too6ob	39	10	authors	author	NNS
cord-263277-m4too6ob	39	11	summarize	summarize	VBP
cord-263277-m4too6ob	39	12	the	the	DT
cord-263277-m4too6ob	39	13	current	current	JJ
cord-263277-m4too6ob	39	14	state	state	NN
cord-263277-m4too6ob	39	15	of	of	IN
cord-263277-m4too6ob	39	16	the	the	DT
cord-263277-m4too6ob	39	17	art	art	NN
cord-263277-m4too6ob	39	18	in	in	IN
cord-263277-m4too6ob	39	19	terms	term	NNS
cord-263277-m4too6ob	39	20	of	of	IN
cord-263277-m4too6ob	39	21	preclinical	preclinical	JJ
cord-263277-m4too6ob	39	22	and	and	CC
cord-263277-m4too6ob	39	23	clinical	clinical	JJ
cord-263277-m4too6ob	39	24	studies	study	NNS
cord-263277-m4too6ob	39	25	,	,	,
cord-263277-m4too6ob	39	26	as	as	RB
cord-263277-m4too6ob	39	27	well	well	RB
cord-263277-m4too6ob	39	28	as	as	IN
cord-263277-m4too6ob	39	29	the	the	DT
cord-263277-m4too6ob	39	30	major	major	JJ
cord-263277-m4too6ob	39	31	roadblocks	roadblock	NNS
cord-263277-m4too6ob	39	32	that	that	WDT
cord-263277-m4too6ob	39	33	need	need	VBP
cord-263277-m4too6ob	39	34	to	to	TO
cord-263277-m4too6ob	39	35	be	be	VB
cord-263277-m4too6ob	39	36	overcome	overcome	VBN
cord-263277-m4too6ob	39	37	for	for	IN
cord-263277-m4too6ob	39	38	implementation	implementation	NN
cord-263277-m4too6ob	39	39	[	[	-LRB-
cord-263277-m4too6ob	39	40	16	16	CD
cord-263277-m4too6ob	39	41	]	]	-RRB-
cord-263277-m4too6ob	39	42	.	.	.
cord-263277-m4too6ob	40	1	In	in	IN
cord-263277-m4too6ob	40	2	this	this	DT
cord-263277-m4too6ob	40	3	context	context	NN
cord-263277-m4too6ob	40	4	,	,	,
cord-263277-m4too6ob	40	5	they	-PRON-	PRP
cord-263277-m4too6ob	40	6	describe	describe	VBP
cord-263277-m4too6ob	40	7	the	the	DT
cord-263277-m4too6ob	40	8	strategies	strategy	NNS
cord-263277-m4too6ob	40	9	exploited	exploit	VBN
cord-263277-m4too6ob	40	10	to	to	TO
cord-263277-m4too6ob	40	11	increase	increase	VB
cord-263277-m4too6ob	40	12	the	the	DT
cord-263277-m4too6ob	40	13	half	half	JJ
cord-263277-m4too6ob	40	14	-	-	HYPH
cord-263277-m4too6ob	40	15	life	life	NN
cord-263277-m4too6ob	40	16	,	,	,
cord-263277-m4too6ob	40	17	stability	stability	NN
cord-263277-m4too6ob	40	18	,	,	,
cord-263277-m4too6ob	40	19	cellular	cellular	JJ
cord-263277-m4too6ob	40	20	uptake	uptake	NN
cord-263277-m4too6ob	40	21	and	and	CC
cord-263277-m4too6ob	40	22	translatability	translatability	NN
cord-263277-m4too6ob	40	23	of	of	IN
cord-263277-m4too6ob	40	24	both	both	CC
cord-263277-m4too6ob	40	25	self	self	NN
cord-263277-m4too6ob	40	26	-	-	HYPH
cord-263277-m4too6ob	40	27	amplifying	amplify	VBG
cord-263277-m4too6ob	40	28	and	and	CC
cord-263277-m4too6ob	40	29	non	non	JJ
cord-263277-m4too6ob	40	30	-	-	JJ
cord-263277-m4too6ob	40	31	replicating	replicating	JJ
cord-263277-m4too6ob	40	32	mRNA	mrna	NN
cord-263277-m4too6ob	40	33	.	.	.
cord-263277-m4too6ob	41	1	A	a	DT
cord-263277-m4too6ob	41	2	distinctive	distinctive	JJ
cord-263277-m4too6ob	41	3	strength	strength	NN
cord-263277-m4too6ob	41	4	of	of	IN
cord-263277-m4too6ob	41	5	this	this	DT
cord-263277-m4too6ob	41	6	class	class	NN
cord-263277-m4too6ob	41	7	of	of	IN
cord-263277-m4too6ob	41	8	vaccines	vaccine	NNS
cord-263277-m4too6ob	41	9	is	be	VBZ
cord-263277-m4too6ob	41	10	their	-PRON-	PRP$
cord-263277-m4too6ob	41	11	rapid	rapid	JJ
cord-263277-m4too6ob	41	12	scalable	scalable	JJ
cord-263277-m4too6ob	41	13	egg	egg	NN
cord-263277-m4too6ob	41	14	-	-	HYPH
cord-263277-m4too6ob	41	15	independent	independent	JJ
cord-263277-m4too6ob	41	16	production	production	NN
cord-263277-m4too6ob	41	17	.	.	.
cord-263277-m4too6ob	42	1	Of	of	IN
cord-263277-m4too6ob	42	2	particular	particular	JJ
cord-263277-m4too6ob	42	3	interest	interest	NN
cord-263277-m4too6ob	42	4	is	be	VBZ
cord-263277-m4too6ob	42	5	the	the	DT
cord-263277-m4too6ob	42	6	analysis	analysis	NN
cord-263277-m4too6ob	42	7	presented	present	VBN
cord-263277-m4too6ob	42	8	in	in	IN
cord-263277-m4too6ob	42	9	this	this	DT
cord-263277-m4too6ob	42	10	review	review	NN
cord-263277-m4too6ob	42	11	benchmarking	benchmarke	VBG
cord-263277-m4too6ob	42	12	the	the	DT
cord-263277-m4too6ob	42	13	strengths	strength	NNS
cord-263277-m4too6ob	42	14	and	and	CC
cord-263277-m4too6ob	42	15	limitations	limitation	NNS
cord-263277-m4too6ob	42	16	of	of	IN
cord-263277-m4too6ob	42	17	this	this	DT
cord-263277-m4too6ob	42	18	class	class	NN
cord-263277-m4too6ob	42	19	of	of	IN
cord-263277-m4too6ob	42	20	vaccines	vaccine	NNS
cord-263277-m4too6ob	42	21	in	in	IN
cord-263277-m4too6ob	42	22	terms	term	NNS
cord-263277-m4too6ob	42	23	of	of	IN
cord-263277-m4too6ob	42	24	the	the	DT
cord-263277-m4too6ob	42	25	World	World	NNP
cord-263277-m4too6ob	42	26	Health	Health	NNP
cord-263277-m4too6ob	42	27	Organization	Organization	NNP
cord-263277-m4too6ob	42	28	guidelines	guideline	NNS
cord-263277-m4too6ob	42	29	for	for	IN
cord-263277-m4too6ob	42	30	the	the	DT
cord-263277-m4too6ob	42	31	preferred	preferred	JJ
cord-263277-m4too6ob	42	32	product	product	NN
cord-263277-m4too6ob	42	33	characteristics	characteristic	NNS
cord-263277-m4too6ob	42	34	of	of	IN
cord-263277-m4too6ob	42	35	next	next	JJ
cord-263277-m4too6ob	42	36	generation	generation	NN
cord-263277-m4too6ob	42	37	influenza	influenza	NN
cord-263277-m4too6ob	42	38	vaccines	vaccine	NNS
cord-263277-m4too6ob	42	39	[	[	-LRB-
cord-263277-m4too6ob	42	40	17	17	CD
cord-263277-m4too6ob	42	41	]	]	-RRB-
cord-263277-m4too6ob	42	42	.	.	.
cord-263277-m4too6ob	43	1	The	the	DT
cord-263277-m4too6ob	43	2	availability	availability	NN
cord-263277-m4too6ob	43	3	of	of	IN
cord-263277-m4too6ob	43	4	innovative	innovative	JJ
cord-263277-m4too6ob	43	5	technologies	technology	NNS
cord-263277-m4too6ob	43	6	will	will	MD
cord-263277-m4too6ob	43	7	certainly	certainly	RB
cord-263277-m4too6ob	43	8	positively	positively	RB
cord-263277-m4too6ob	43	9	affect	affect	VB
cord-263277-m4too6ob	43	10	the	the	DT
cord-263277-m4too6ob	43	11	development	development	NN
cord-263277-m4too6ob	43	12	of	of	IN
cord-263277-m4too6ob	43	13	next	next	JJ
cord-263277-m4too6ob	43	14	generation	generation	NN
cord-263277-m4too6ob	43	15	influenza	influenza	NN
cord-263277-m4too6ob	43	16	vaccines	vaccine	NNS
cord-263277-m4too6ob	43	17	.	.	.
cord-263277-m4too6ob	44	1	However	however	RB
cord-263277-m4too6ob	44	2	,	,	,
cord-263277-m4too6ob	44	3	influenza	influenza	NN
cord-263277-m4too6ob	44	4	vaccines	vaccine	NNS
cord-263277-m4too6ob	44	5	based	base	VBN
cord-263277-m4too6ob	44	6	on	on	IN
cord-263277-m4too6ob	44	7	both	both	DT
cord-263277-m4too6ob	44	8	traditional	traditional	JJ
cord-263277-m4too6ob	44	9	and	and	CC
cord-263277-m4too6ob	44	10	emerging	emerging	JJ
cord-263277-m4too6ob	44	11	technologies	technology	NNS
cord-263277-m4too6ob	44	12	face	face	VBP
cord-263277-m4too6ob	44	13	the	the	DT
cord-263277-m4too6ob	44	14	major	major	JJ
cord-263277-m4too6ob	44	15	constraint	constraint	NN
cord-263277-m4too6ob	44	16	represented	represent	VBN
cord-263277-m4too6ob	44	17	by	by	IN
cord-263277-m4too6ob	44	18	the	the	DT
cord-263277-m4too6ob	44	19	immune	immune	JJ
cord-263277-m4too6ob	44	20	history	history	NN
cord-263277-m4too6ob	44	21	of	of	IN
cord-263277-m4too6ob	44	22	the	the	DT
cord-263277-m4too6ob	44	23	individual	individual	JJ
cord-263277-m4too6ob	44	24	vaccinees	vaccinee	NNS
cord-263277-m4too6ob	44	25	.	.	.
cord-263277-m4too6ob	45	1	The	the	DT
cord-263277-m4too6ob	45	2	review	review	NN
cord-263277-m4too6ob	45	3	article	article	NN
cord-263277-m4too6ob	45	4	from	from	IN
cord-263277-m4too6ob	45	5	Lewnard	Lewnard	NNP
cord-263277-m4too6ob	45	6	and	and	CC
cord-263277-m4too6ob	45	7	Cobey	Cobey	NNP
cord-263277-m4too6ob	45	8	analyze	analyze	VBP
cord-263277-m4too6ob	45	9	the	the	DT
cord-263277-m4too6ob	45	10	specific	specific	JJ
cord-263277-m4too6ob	45	11	constraints	constraint	NNS
cord-263277-m4too6ob	45	12	and	and	CC
cord-263277-m4too6ob	45	13	provide	provide	VB
cord-263277-m4too6ob	45	14	examples	example	NNS
cord-263277-m4too6ob	45	15	on	on	IN
cord-263277-m4too6ob	45	16	how	how	WRB
cord-263277-m4too6ob	45	17	the	the	DT
cord-263277-m4too6ob	45	18	dynamics	dynamic	NNS
cord-263277-m4too6ob	45	19	of	of	IN
cord-263277-m4too6ob	45	20	immune	immune	JJ
cord-263277-m4too6ob	45	21	memory	memory	NN
cord-263277-m4too6ob	45	22	can	can	MD
cord-263277-m4too6ob	45	23	affect	affect	VB
cord-263277-m4too6ob	45	24	vaccine	vaccine	NN
cord-263277-m4too6ob	45	25	effectiveness	effectiveness	NN
cord-263277-m4too6ob	45	26	[	[	-LRB-
cord-263277-m4too6ob	45	27	18	18	CD
cord-263277-m4too6ob	45	28	]	]	-RRB-
cord-263277-m4too6ob	45	29	.	.	.
cord-263277-m4too6ob	46	1	It	-PRON-	PRP
cord-263277-m4too6ob	46	2	is	be	VBZ
cord-263277-m4too6ob	46	3	critical	critical	JJ
cord-263277-m4too6ob	46	4	to	to	TO
cord-263277-m4too6ob	46	5	understand	understand	VB
cord-263277-m4too6ob	46	6	the	the	DT
cord-263277-m4too6ob	46	7	underlying	underlie	VBG
cord-263277-m4too6ob	46	8	mechanisms	mechanism	NNS
cord-263277-m4too6ob	46	9	driving	drive	VBG
cord-263277-m4too6ob	46	10	these	these	DT
cord-263277-m4too6ob	46	11	processes	process	NNS
cord-263277-m4too6ob	46	12	,	,	,
cord-263277-m4too6ob	46	13	which	which	WDT
cord-263277-m4too6ob	46	14	go	go	VBP
cord-263277-m4too6ob	46	15	far	far	RB
cord-263277-m4too6ob	46	16	beyond	beyond	IN
cord-263277-m4too6ob	46	17	the	the	DT
cord-263277-m4too6ob	46	18	potential	potential	JJ
cord-263277-m4too6ob	46	19	impact	impact	NN
cord-263277-m4too6ob	46	20	of	of	IN
cord-263277-m4too6ob	46	21	the	the	DT
cord-263277-m4too6ob	46	22	original	original	JJ
cord-263277-m4too6ob	46	23	antigenic	antigenic	JJ
cord-263277-m4too6ob	46	24	sin	sin	NN
cord-263277-m4too6ob	46	25	during	during	IN
cord-263277-m4too6ob	46	26	immune	immune	JJ
cord-263277-m4too6ob	46	27	imprinting	imprinting	NN
cord-263277-m4too6ob	46	28	.	.	.
cord-263277-m4too6ob	47	1	This	this	DT
cord-263277-m4too6ob	47	2	will	will	MD
cord-263277-m4too6ob	47	3	allow	allow	VB
cord-263277-m4too6ob	47	4	dissecting	dissect	VBG
cord-263277-m4too6ob	47	5	differential	differential	JJ
cord-263277-m4too6ob	47	6	patterns	pattern	NNS
cord-263277-m4too6ob	47	7	of	of	IN
cord-263277-m4too6ob	47	8	vaccine	vaccine	NN
cord-263277-m4too6ob	47	9	effectiveness	effectiveness	NN
cord-263277-m4too6ob	47	10	in	in	IN
cord-263277-m4too6ob	47	11	vaccinees	vaccinee	NNS
cord-263277-m4too6ob	47	12	depending	depend	VBG
cord-263277-m4too6ob	47	13	on	on	IN
cord-263277-m4too6ob	47	14	immune	immune	JJ
cord-263277-m4too6ob	47	15	imprinting	imprinting	NN
cord-263277-m4too6ob	47	16	and	and	CC
cord-263277-m4too6ob	47	17	memory	memory	NN
cord-263277-m4too6ob	47	18	.	.	.
cord-263277-m4too6ob	48	1	Immediately	immediately	RB
cord-263277-m4too6ob	48	2	after	after	IN
cord-263277-m4too6ob	48	3	birth	birth	NN
cord-263277-m4too6ob	48	4	,	,	,
cord-263277-m4too6ob	48	5	human	human	JJ
cord-263277-m4too6ob	48	6	beings	being	NNS
cord-263277-m4too6ob	48	7	lose	lose	VBP
cord-263277-m4too6ob	48	8	their	-PRON-	PRP$
cord-263277-m4too6ob	48	9	naivety	naivety	NN
cord-263277-m4too6ob	48	10	,	,	,
cord-263277-m4too6ob	48	11	and	and	CC
cord-263277-m4too6ob	48	12	previous	previous	JJ
cord-263277-m4too6ob	48	13	infection	infection	NN
cord-263277-m4too6ob	48	14	and	and	CC
cord-263277-m4too6ob	48	15	vaccination	vaccination	NN
cord-263277-m4too6ob	48	16	events	event	NNS
cord-263277-m4too6ob	48	17	condition	condition	NN
cord-263277-m4too6ob	48	18	responsiveness	responsiveness	NN
cord-263277-m4too6ob	48	19	,	,	,
cord-263277-m4too6ob	48	20	for	for	IN
cord-263277-m4too6ob	48	21	good	good	JJ
cord-263277-m4too6ob	48	22	or	or	CC
cord-263277-m4too6ob	48	23	bad	bad	JJ
cord-263277-m4too6ob	48	24	,	,	,
cord-263277-m4too6ob	48	25	from	from	IN
cord-263277-m4too6ob	48	26	season	season	NN
cord-263277-m4too6ob	48	27	to	to	IN
cord-263277-m4too6ob	48	28	season	season	NN
cord-263277-m4too6ob	48	29	,	,	,
cord-263277-m4too6ob	48	30	according	accord	VBG
cord-263277-m4too6ob	48	31	to	to	IN
cord-263277-m4too6ob	48	32	age	age	NN
cord-263277-m4too6ob	48	33	and	and	CC
cord-263277-m4too6ob	48	34	the	the	DT
cord-263277-m4too6ob	48	35	antigen	antigen	NN
cord-263277-m4too6ob	48	36	contact	contact	NN
cord-263277-m4too6ob	48	37	history	history	NN
cord-263277-m4too6ob	48	38	.	.	.
cord-263277-m4too6ob	49	1	The	the	DT
cord-263277-m4too6ob	49	2	rational	rational	JJ
cord-263277-m4too6ob	49	3	design	design	NN
cord-263277-m4too6ob	49	4	of	of	IN
cord-263277-m4too6ob	49	5	next	next	JJ
cord-263277-m4too6ob	49	6	generation	generation	NN
cord-263277-m4too6ob	49	7	influenza	influenza	NN
cord-263277-m4too6ob	49	8	vaccines	vaccine	NNS
cord-263277-m4too6ob	49	9	able	able	JJ
cord-263277-m4too6ob	49	10	to	to	TO
cord-263277-m4too6ob	49	11	confer	confer	VB
cord-263277-m4too6ob	49	12	protection	protection	NN
cord-263277-m4too6ob	49	13	in	in	IN
cord-263277-m4too6ob	49	14	all	all	DT
cord-263277-m4too6ob	49	15	age	age	NN
cord-263277-m4too6ob	49	16	and	and	CC
cord-263277-m4too6ob	49	17	vulnerable	vulnerable	JJ
cord-263277-m4too6ob	49	18	groups	group	NNS
cord-263277-m4too6ob	49	19	is	be	VBZ
cord-263277-m4too6ob	49	20	an	an	DT
cord-263277-m4too6ob	49	21	ambitious	ambitious	JJ
cord-263277-m4too6ob	49	22	and	and	CC
cord-263277-m4too6ob	49	23	challenging	challenging	JJ
cord-263277-m4too6ob	49	24	venture	venture	NN
cord-263277-m4too6ob	49	25	.	.	.
cord-263277-m4too6ob	50	1	Different	different	JJ
cord-263277-m4too6ob	50	2	approaches	approach	NNS
cord-263277-m4too6ob	50	3	can	can	MD
cord-263277-m4too6ob	50	4	be	be	VB
cord-263277-m4too6ob	50	5	exploited	exploit	VBN
cord-263277-m4too6ob	50	6	to	to	TO
cord-263277-m4too6ob	50	7	stimulate	stimulate	VB
cord-263277-m4too6ob	50	8	the	the	DT
cord-263277-m4too6ob	50	9	production	production	NN
cord-263277-m4too6ob	50	10	of	of	IN
cord-263277-m4too6ob	50	11	broadly	broadly	RB
cord-263277-m4too6ob	50	12	protective	protective	JJ
cord-263277-m4too6ob	50	13	vaccine	vaccine	NN
cord-263277-m4too6ob	50	14	responses	response	NNS
cord-263277-m4too6ob	50	15	[	[	-LRB-
cord-263277-m4too6ob	50	16	19	19	CD
cord-263277-m4too6ob	50	17	]	]	-RRB-
cord-263277-m4too6ob	50	18	.	.	.
cord-263277-m4too6ob	51	1	Among	among	IN
cord-263277-m4too6ob	51	2	them	-PRON-	PRP
cord-263277-m4too6ob	51	3	,	,	,
cord-263277-m4too6ob	51	4	the	the	DT
cord-263277-m4too6ob	51	5	more	more	RBR
cord-263277-m4too6ob	51	6	conserved	conserved	JJ
cord-263277-m4too6ob	51	7	structures	structure	NNS
cord-263277-m4too6ob	51	8	of	of	IN
cord-263277-m4too6ob	51	9	the	the	DT
cord-263277-m4too6ob	51	10	virus	virus	NN
cord-263277-m4too6ob	51	11	are	be	VBP
cord-263277-m4too6ob	51	12	used	use	VBN
cord-263277-m4too6ob	51	13	as	as	IN
cord-263277-m4too6ob	51	14	an	an	DT
cord-263277-m4too6ob	51	15	antigenic	antigenic	JJ
cord-263277-m4too6ob	51	16	target	target	NN
cord-263277-m4too6ob	51	17	,	,	,
cord-263277-m4too6ob	51	18	such	such	JJ
cord-263277-m4too6ob	51	19	as	as	IN
cord-263277-m4too6ob	51	20	the	the	DT
cord-263277-m4too6ob	51	21	stalk	stalk	NN
cord-263277-m4too6ob	51	22	region	region	NN
cord-263277-m4too6ob	51	23	of	of	IN
cord-263277-m4too6ob	51	24	the	the	DT
cord-263277-m4too6ob	51	25	hemagglutinin	hemagglutinin	NN
cord-263277-m4too6ob	51	26	,	,	,
cord-263277-m4too6ob	51	27	or	or	CC
cord-263277-m4too6ob	51	28	the	the	DT
cord-263277-m4too6ob	51	29	matrix	matrix	NN
cord-263277-m4too6ob	51	30	protein	protein	NN
cord-263277-m4too6ob	51	31	2	2	CD
cord-263277-m4too6ob	51	32	,	,	,
cord-263277-m4too6ob	51	33	which	which	WDT
cord-263277-m4too6ob	51	34	is	be	VBZ
cord-263277-m4too6ob	51	35	highly	highly	RB
cord-263277-m4too6ob	51	36	conserved	conserve	VBN
cord-263277-m4too6ob	51	37	between	between	IN
cord-263277-m4too6ob	51	38	influenza	influenza	NN
cord-263277-m4too6ob	51	39	subtypes	subtype	NNS
cord-263277-m4too6ob	51	40	.	.	.
cord-263277-m4too6ob	52	1	An	an	DT
cord-263277-m4too6ob	52	2	alternative	alternative	JJ
cord-263277-m4too6ob	52	3	approach	approach	NN
cord-263277-m4too6ob	52	4	relies	rely	VBZ
cord-263277-m4too6ob	52	5	on	on	IN
cord-263277-m4too6ob	52	6	the	the	DT
cord-263277-m4too6ob	52	7	exploitation	exploitation	NN
cord-263277-m4too6ob	52	8	of	of	IN
cord-263277-m4too6ob	52	9	in	in	IN
cord-263277-m4too6ob	52	10	silico	silico	NN
cord-263277-m4too6ob	52	11	tools	tool	NNS
cord-263277-m4too6ob	52	12	to	to	TO
cord-263277-m4too6ob	52	13	develop	develop	VB
cord-263277-m4too6ob	52	14	consensus	consensus	NN
cord-263277-m4too6ob	52	15	sequences	sequence	NNS
cord-263277-m4too6ob	52	16	for	for	IN
cord-263277-m4too6ob	52	17	computationally	computationally	RB
cord-263277-m4too6ob	52	18	optimized	optimize	VBN
cord-263277-m4too6ob	52	19	broadly	broadly	RB
cord-263277-m4too6ob	52	20	reactive	reactive	JJ
cord-263277-m4too6ob	52	21	hemagglutinin	hemagglutinin	NN
cord-263277-m4too6ob	52	22	antigen	antigen	NN
cord-263277-m4too6ob	52	23	variants	variant	NNS
cord-263277-m4too6ob	52	24	(	(	-LRB-
cord-263277-m4too6ob	52	25	COBRA	COBRA	NNP
cord-263277-m4too6ob	52	26	)	)	-RRB-
cord-263277-m4too6ob	52	27	,	,	,
cord-263277-m4too6ob	52	28	which	which	WDT
cord-263277-m4too6ob	52	29	are	be	VBP
cord-263277-m4too6ob	52	30	able	able	JJ
cord-263277-m4too6ob	52	31	to	to	TO
cord-263277-m4too6ob	52	32	stimulate	stimulate	VB
cord-263277-m4too6ob	52	33	broadly	broadly	RB
cord-263277-m4too6ob	52	34	reactive	reactive	JJ
cord-263277-m4too6ob	52	35	antibodies	antibody	NNS
cord-263277-m4too6ob	52	36	[	[	-LRB-
cord-263277-m4too6ob	52	37	20	20	CD
cord-263277-m4too6ob	52	38	]	]	-RRB-
cord-263277-m4too6ob	52	39	.	.	.
cord-263277-m4too6ob	53	1	The	the	DT
cord-263277-m4too6ob	53	2	use	use	NN
cord-263277-m4too6ob	53	3	of	of	IN
cord-263277-m4too6ob	53	4	some	some	DT
cord-263277-m4too6ob	53	5	of	of	IN
cord-263277-m4too6ob	53	6	these	these	DT
cord-263277-m4too6ob	53	7	approaches	approach	NNS
cord-263277-m4too6ob	53	8	might	may	MD
cord-263277-m4too6ob	53	9	require	require	VB
cord-263277-m4too6ob	53	10	the	the	DT
cord-263277-m4too6ob	53	11	development	development	NN
cord-263277-m4too6ob	53	12	of	of	IN
cord-263277-m4too6ob	53	13	alternative	alternative	JJ
cord-263277-m4too6ob	53	14	tools	tool	NNS
cord-263277-m4too6ob	53	15	to	to	TO
cord-263277-m4too6ob	53	16	assess	assess	VB
cord-263277-m4too6ob	53	17	vaccine	vaccine	NN
cord-263277-m4too6ob	53	18	efficacy	efficacy	NN
cord-263277-m4too6ob	53	19	.	.	.
cord-263277-m4too6ob	54	1	Current	current	JJ
cord-263277-m4too6ob	54	2	surrogated	surrogated	JJ
cord-263277-m4too6ob	54	3	correlates	correlate	VBZ
cord-263277-m4too6ob	54	4	of	of	IN
cord-263277-m4too6ob	54	5	protection	protection	NN
cord-263277-m4too6ob	54	6	,	,	,
cord-263277-m4too6ob	54	7	which	which	WDT
cord-263277-m4too6ob	54	8	are	be	VBP
cord-263277-m4too6ob	54	9	accepted	accept	VBN
cord-263277-m4too6ob	54	10	for	for	IN
cord-263277-m4too6ob	54	11	the	the	DT
cord-263277-m4too6ob	54	12	standard	standard	JJ
cord-263277-m4too6ob	54	13	influenza	influenza	NN
cord-263277-m4too6ob	54	14	vaccines	vaccine	NNS
cord-263277-m4too6ob	54	15	,	,	,
cord-263277-m4too6ob	54	16	may	may	MD
cord-263277-m4too6ob	54	17	not	not	RB
cord-263277-m4too6ob	54	18	be	be	VB
cord-263277-m4too6ob	54	19	relevant	relevant	JJ
cord-263277-m4too6ob	54	20	for	for	IN
cord-263277-m4too6ob	54	21	next	next	JJ
cord-263277-m4too6ob	54	22	generation	generation	NN
cord-263277-m4too6ob	54	23	vaccines	vaccine	NNS
cord-263277-m4too6ob	54	24	.	.	.
cord-263277-m4too6ob	55	1	In	in	IN
cord-263277-m4too6ob	55	2	fact	fact	NN
cord-263277-m4too6ob	55	3	,	,	,
cord-263277-m4too6ob	55	4	the	the	DT
cord-263277-m4too6ob	55	5	stimulated	stimulated	JJ
cord-263277-m4too6ob	55	6	clearance	clearance	NN
cord-263277-m4too6ob	55	7	mechanism	mechanism	NN
cord-263277-m4too6ob	55	8	might	may	MD
cord-263277-m4too6ob	55	9	go	go	VB
cord-263277-m4too6ob	55	10	far	far	RB
cord-263277-m4too6ob	55	11	beyond	beyond	IN
cord-263277-m4too6ob	55	12	traditional	traditional	JJ
cord-263277-m4too6ob	55	13	neutralization	neutralization	NN
cord-263277-m4too6ob	55	14	by	by	IN
cord-263277-m4too6ob	55	15	blocking	block	VBG
cord-263277-m4too6ob	55	16	the	the	DT
cord-263277-m4too6ob	55	17	virus	virus	NN
cord-263277-m4too6ob	55	18	binding	bind	VBG
cord-263277-m4too6ob	55	19	to	to	IN
cord-263277-m4too6ob	55	20	the	the	DT
cord-263277-m4too6ob	55	21	receptor	receptor	NN
cord-263277-m4too6ob	55	22	(	(	-LRB-
cord-263277-m4too6ob	55	23	e.g.	e.g.	RB
cord-263277-m4too6ob	55	24	,	,	,
cord-263277-m4too6ob	55	25	the	the	DT
cord-263277-m4too6ob	55	26	inhibition	inhibition	NN
cord-263277-m4too6ob	55	27	of	of	IN
cord-263277-m4too6ob	55	28	viral	viral	JJ
cord-263277-m4too6ob	55	29	membrane	membrane	NN
cord-263277-m4too6ob	55	30	fusion	fusion	NN
cord-263277-m4too6ob	55	31	and	and	CC
cord-263277-m4too6ob	55	32	maturation	maturation	NN
cord-263277-m4too6ob	55	33	,	,	,
cord-263277-m4too6ob	55	34	antibody	antibody	NN
cord-263277-m4too6ob	55	35	-	-	HYPH
cord-263277-m4too6ob	55	36	dependent	dependent	JJ
cord-263277-m4too6ob	55	37	and	and	CC
cord-263277-m4too6ob	55	38	-independent	-independent	JJ
cord-263277-m4too6ob	55	39	cytotoxicity	cytotoxicity	NN
cord-263277-m4too6ob	55	40	,	,	,
cord-263277-m4too6ob	55	41	the	the	DT
cord-263277-m4too6ob	55	42	inhibition	inhibition	NN
cord-263277-m4too6ob	55	43	of	of	IN
cord-263277-m4too6ob	55	44	viral	viral	JJ
cord-263277-m4too6ob	55	45	replication	replication	NN
cord-263277-m4too6ob	55	46	or	or	CC
cord-263277-m4too6ob	55	47	spreading	spreading	NN
cord-263277-m4too6ob	55	48	)	)	-RRB-
cord-263277-m4too6ob	55	49	.	.	.
cord-263277-m4too6ob	56	1	Interestingly	interestingly	RB
cord-263277-m4too6ob	56	2	,	,	,
cord-263277-m4too6ob	56	3	the	the	DT
cord-263277-m4too6ob	56	4	adjuvantation	adjuvantation	NN
cord-263277-m4too6ob	56	5	of	of	IN
cord-263277-m4too6ob	56	6	conventional	conventional	JJ
cord-263277-m4too6ob	56	7	influenza	influenza	NN
cord-263277-m4too6ob	56	8	vaccines	vaccine	NNS
cord-263277-m4too6ob	56	9	has	have	VBZ
cord-263277-m4too6ob	56	10	also	also	RB
cord-263277-m4too6ob	56	11	proven	prove	VBN
cord-263277-m4too6ob	56	12	effective	effective	JJ
cord-263277-m4too6ob	56	13	,	,	,
cord-263277-m4too6ob	56	14	not	not	RB
cord-263277-m4too6ob	56	15	only	only	RB
cord-263277-m4too6ob	56	16	for	for	IN
cord-263277-m4too6ob	56	17	improving	improve	VBG
cord-263277-m4too6ob	56	18	responsiveness	responsiveness	NN
cord-263277-m4too6ob	56	19	in	in	IN
cord-263277-m4too6ob	56	20	certain	certain	JJ
cord-263277-m4too6ob	56	21	subpopulation	subpopulation	NN
cord-263277-m4too6ob	56	22	groups	group	NNS
cord-263277-m4too6ob	56	23	[	[	-LRB-
cord-263277-m4too6ob	56	24	21	21	CD
cord-263277-m4too6ob	56	25	]	]	-RRB-
cord-263277-m4too6ob	56	26	,	,	,
cord-263277-m4too6ob	56	27	but	but	CC
cord-263277-m4too6ob	56	28	also	also	RB
cord-263277-m4too6ob	56	29	at	at	IN
cord-263277-m4too6ob	56	30	broadening	broaden	VBG
cord-263277-m4too6ob	56	31	responsiveness	responsiveness	NN
cord-263277-m4too6ob	56	32	to	to	IN
cord-263277-m4too6ob	56	33	other	other	JJ
cord-263277-m4too6ob	56	34	influenza	influenza	NN
cord-263277-m4too6ob	56	35	subtypes	subtype	NNS
cord-263277-m4too6ob	56	36	[	[	-LRB-
cord-263277-m4too6ob	56	37	22	22	CD
cord-263277-m4too6ob	56	38	,	,	,
cord-263277-m4too6ob	56	39	23	23	CD
cord-263277-m4too6ob	56	40	]	]	-RRB-
cord-263277-m4too6ob	56	41	.	.	.
cord-263277-m4too6ob	57	1	A	a	DT
cord-263277-m4too6ob	57	2	critical	critical	JJ
cord-263277-m4too6ob	57	3	aspect	aspect	NN
cord-263277-m4too6ob	57	4	for	for	IN
cord-263277-m4too6ob	57	5	the	the	DT
cord-263277-m4too6ob	57	6	development	development	NN
cord-263277-m4too6ob	57	7	of	of	IN
cord-263277-m4too6ob	57	8	a	a	DT
cord-263277-m4too6ob	57	9	vaccine	vaccine	NN
cord-263277-m4too6ob	57	10	conferring	confer	VBG
cord-263277-m4too6ob	57	11	broad	broad	JJ
cord-263277-m4too6ob	57	12	cross	cross	JJ
cord-263277-m4too6ob	57	13	-	-	JJ
cord-263277-m4too6ob	57	14	protective	protective	JJ
cord-263277-m4too6ob	57	15	immunity	immunity	NN
cord-263277-m4too6ob	57	16	against	against	IN
cord-263277-m4too6ob	57	17	influenza	influenza	NN
cord-263277-m4too6ob	57	18	is	be	VBZ
cord-263277-m4too6ob	57	19	the	the	DT
cord-263277-m4too6ob	57	20	determination	determination	NN
cord-263277-m4too6ob	57	21	of	of	IN
cord-263277-m4too6ob	57	22	vaccine	vaccine	NN
cord-263277-m4too6ob	57	23	efficacy	efficacy	NN
cord-263277-m4too6ob	57	24	.	.	.
cord-263277-m4too6ob	58	1	The	the	DT
cord-263277-m4too6ob	58	2	clinical	clinical	JJ
cord-263277-m4too6ob	58	3	trials	trial	NNS
cord-263277-m4too6ob	58	4	required	require	VBN
cord-263277-m4too6ob	58	5	to	to	TO
cord-263277-m4too6ob	58	6	achieve	achieve	VB
cord-263277-m4too6ob	58	7	this	this	DT
cord-263277-m4too6ob	58	8	goal	goal	NN
cord-263277-m4too6ob	58	9	may	may	MD
cord-263277-m4too6ob	58	10	prove	prove	VB
cord-263277-m4too6ob	58	11	a	a	DT
cord-263277-m4too6ob	58	12	roadblock	roadblock	NN
cord-263277-m4too6ob	58	13	.	.	.
cord-263277-m4too6ob	59	1	However	however	RB
cord-263277-m4too6ob	59	2	,	,	,
cord-263277-m4too6ob	59	3	the	the	DT
cord-263277-m4too6ob	59	4	availability	availability	NN
cord-263277-m4too6ob	59	5	of	of	IN
cord-263277-m4too6ob	59	6	controlled	control	VBN
cord-263277-m4too6ob	59	7	human	human	JJ
cord-263277-m4too6ob	59	8	infection	infection	NN
cord-263277-m4too6ob	59	9	models	model	NNS
cord-263277-m4too6ob	59	10	for	for	IN
cord-263277-m4too6ob	59	11	the	the	DT
cord-263277-m4too6ob	59	12	influenza	influenza	NN
cord-263277-m4too6ob	59	13	virus	virus	NN
cord-263277-m4too6ob	59	14	is	be	VBZ
cord-263277-m4too6ob	59	15	an	an	DT
cord-263277-m4too6ob	59	16	effective	effective	JJ
cord-263277-m4too6ob	59	17	alternative	alternative	NN
cord-263277-m4too6ob	59	18	to	to	TO
cord-263277-m4too6ob	59	19	address	address	VB
cord-263277-m4too6ob	59	20	this	this	DT
cord-263277-m4too6ob	59	21	issue	issue	NN
cord-263277-m4too6ob	59	22	[	[	-LRB-
cord-263277-m4too6ob	59	23	24	24	CD
cord-263277-m4too6ob	59	24	]	]	-RRB-
cord-263277-m4too6ob	59	25	.	.	.
cord-263277-m4too6ob	60	1	Whether	whether	IN
cord-263277-m4too6ob	60	2	these	these	DT
cord-263277-m4too6ob	60	3	approaches	approach	NNS
cord-263277-m4too6ob	60	4	can	can	MD
cord-263277-m4too6ob	60	5	lead	lead	VB
cord-263277-m4too6ob	60	6	to	to	IN
cord-263277-m4too6ob	60	7	a	a	DT
cord-263277-m4too6ob	60	8	true	true	JJ
cord-263277-m4too6ob	60	9	universal	universal	JJ
cord-263277-m4too6ob	60	10	influenza	influenza	NN
cord-263277-m4too6ob	60	11	vaccine	vaccine	NN
cord-263277-m4too6ob	60	12	or	or	CC
cord-263277-m4too6ob	60	13	to	to	IN
cord-263277-m4too6ob	60	14	next	next	JJ
cord-263277-m4too6ob	60	15	generation	generation	NN
cord-263277-m4too6ob	60	16	vaccines	vaccine	NNS
cord-263277-m4too6ob	60	17	with	with	IN
cord-263277-m4too6ob	60	18	a	a	DT
cord-263277-m4too6ob	60	19	broader	broad	JJR
cord-263277-m4too6ob	60	20	efficacy	efficacy	NN
cord-263277-m4too6ob	60	21	profile	profile	NN
cord-263277-m4too6ob	60	22	,	,	,
cord-263277-m4too6ob	60	23	rendering	render	VBG
cord-263277-m4too6ob	60	24	possible	possible	JJ
cord-263277-m4too6ob	60	25	to	to	TO
cord-263277-m4too6ob	60	26	boost	boost	VB
cord-263277-m4too6ob	60	27	against	against	IN
cord-263277-m4too6ob	60	28	seasonal	seasonal	JJ
cord-263277-m4too6ob	60	29	influenza	influenza	NN
cord-263277-m4too6ob	60	30	every	every	DT
cord-263277-m4too6ob	60	31	5	5	CD
cord-263277-m4too6ob	60	32	-	-	SYM
cord-263277-m4too6ob	60	33	10	10	CD
cord-263277-m4too6ob	60	34	years	year	NNS
cord-263277-m4too6ob	60	35	instead	instead	RB
cord-263277-m4too6ob	60	36	of	of	IN
cord-263277-m4too6ob	60	37	every	every	DT
cord-263277-m4too6ob	60	38	year	year	NN
cord-263277-m4too6ob	60	39	,	,	,
cord-263277-m4too6ob	60	40	or	or	CC
cord-263277-m4too6ob	60	41	to	to	TO
cord-263277-m4too6ob	60	42	be	be	VB
cord-263277-m4too6ob	60	43	prepared	prepare	VBN
cord-263277-m4too6ob	60	44	for	for	IN
cord-263277-m4too6ob	60	45	a	a	DT
cord-263277-m4too6ob	60	46	broad	broad	JJ
cord-263277-m4too6ob	60	47	range	range	NN
cord-263277-m4too6ob	60	48	of	of	IN
cord-263277-m4too6ob	60	49	strains	strain	NNS
cord-263277-m4too6ob	60	50	with	with	IN
cord-263277-m4too6ob	60	51	a	a	DT
cord-263277-m4too6ob	60	52	potential	potential	NN
cord-263277-m4too6ob	60	53	to	to	TO
cord-263277-m4too6ob	60	54	cause	cause	VB
cord-263277-m4too6ob	60	55	pandemics	pandemic	NNS
cord-263277-m4too6ob	60	56	,	,	,
cord-263277-m4too6ob	60	57	remains	remain	VBZ
cord-263277-m4too6ob	60	58	to	to	TO
cord-263277-m4too6ob	60	59	be	be	VB
cord-263277-m4too6ob	60	60	elucidate	elucidate	VB
cord-263277-m4too6ob	60	61	.	.	.
cord-263277-m4too6ob	61	1	However	however	RB
cord-263277-m4too6ob	61	2	,	,	,
cord-263277-m4too6ob	61	3	the	the	DT
cord-263277-m4too6ob	61	4	crystallization	crystallization	NN
cord-263277-m4too6ob	61	5	of	of	IN
cord-263277-m4too6ob	61	6	any	any	DT
cord-263277-m4too6ob	61	7	of	of	IN
cord-263277-m4too6ob	61	8	these	these	DT
cord-263277-m4too6ob	61	9	two	two	CD
cord-263277-m4too6ob	61	10	scenarios	scenario	NNS
cord-263277-m4too6ob	61	11	will	will	MD
cord-263277-m4too6ob	61	12	represent	represent	VB
cord-263277-m4too6ob	61	13	a	a	DT
cord-263277-m4too6ob	61	14	significant	significant	JJ
cord-263277-m4too6ob	61	15	improvement	improvement	NN
cord-263277-m4too6ob	61	16	with	with	IN
cord-263277-m4too6ob	61	17	respect	respect	NN
cord-263277-m4too6ob	61	18	to	to	IN
cord-263277-m4too6ob	61	19	the	the	DT
cord-263277-m4too6ob	61	20	current	current	JJ
cord-263277-m4too6ob	61	21	situation	situation	NN
cord-263277-m4too6ob	61	22	.	.	.
cord-263277-m4too6ob	62	1	It	-PRON-	PRP
cord-263277-m4too6ob	62	2	is	be	VBZ
cord-263277-m4too6ob	62	3	important	important	JJ
cord-263277-m4too6ob	62	4	to	to	TO
cord-263277-m4too6ob	62	5	highlight	highlight	VB
cord-263277-m4too6ob	62	6	that	that	IN
cord-263277-m4too6ob	62	7	regardless	regardless	RB
cord-263277-m4too6ob	62	8	of	of	IN
cord-263277-m4too6ob	62	9	the	the	DT
cord-263277-m4too6ob	62	10	fact	fact	NN
cord-263277-m4too6ob	62	11	that	that	IN
cord-263277-m4too6ob	62	12	upcoming	upcome	VBG
cord-263277-m4too6ob	62	13	next	next	JJ
cord-263277-m4too6ob	62	14	generation	generation	NN
cord-263277-m4too6ob	62	15	vaccines	vaccine	NNS
cord-263277-m4too6ob	62	16	are	be	VBP
cord-263277-m4too6ob	62	17	formulated	formulate	VBN
cord-263277-m4too6ob	62	18	with	with	IN
cord-263277-m4too6ob	62	19	well	well	RB
cord-263277-m4too6ob	62	20	known	know	VBN
cord-263277-m4too6ob	62	21	standard	standard	JJ
cord-263277-m4too6ob	62	22	antigens	antigen	NNS
cord-263277-m4too6ob	62	23	or	or	CC
cord-263277-m4too6ob	62	24	innovative	innovative	JJ
cord-263277-m4too6ob	62	25	components	component	NNS
cord-263277-m4too6ob	62	26	promoting	promote	VBG
cord-263277-m4too6ob	62	27	cross	cross	JJ
cord-263277-m4too6ob	62	28	-	-	JJ
cord-263277-m4too6ob	62	29	protective	protective	JJ
cord-263277-m4too6ob	62	30	immunity	immunity	NN
cord-263277-m4too6ob	62	31	,	,	,
cord-263277-m4too6ob	62	32	or	or	CC
cord-263277-m4too6ob	62	33	that	that	IN
cord-263277-m4too6ob	62	34	they	-PRON-	PRP
cord-263277-m4too6ob	62	35	will	will	MD
cord-263277-m4too6ob	62	36	be	be	VB
cord-263277-m4too6ob	62	37	based	base	VBN
cord-263277-m4too6ob	62	38	on	on	IN
cord-263277-m4too6ob	62	39	well	well	RB
cord-263277-m4too6ob	62	40	established	establish	VBN
cord-263277-m4too6ob	62	41	or	or	CC
cord-263277-m4too6ob	62	42	emerging	emerge	VBG
cord-263277-m4too6ob	62	43	technology	technology	NN
cord-263277-m4too6ob	62	44	platforms	platform	NNS
cord-263277-m4too6ob	62	45	for	for	IN
cord-263277-m4too6ob	62	46	vaccine	vaccine	NN
cord-263277-m4too6ob	62	47	formulation	formulation	NN
cord-263277-m4too6ob	62	48	or	or	CC
cord-263277-m4too6ob	62	49	delivery	delivery	NN
cord-263277-m4too6ob	62	50	,	,	,
cord-263277-m4too6ob	62	51	the	the	DT
cord-263277-m4too6ob	62	52	key	key	JJ
cord-263277-m4too6ob	62	53	problem	problem	NN
cord-263277-m4too6ob	62	54	in	in	IN
cord-263277-m4too6ob	62	55	vaccine	vaccine	NN
cord-263277-m4too6ob	62	56	-	-	HYPH
cord-263277-m4too6ob	62	57	mediated	mediate	VBN
cord-263277-m4too6ob	62	58	immunity	immunity	NN
cord-263277-m4too6ob	62	59	against	against	IN
cord-263277-m4too6ob	62	60	influenza	influenza	NN
cord-263277-m4too6ob	62	61	will	will	MD
cord-263277-m4too6ob	62	62	remain	remain	VB
cord-263277-m4too6ob	62	63	.	.	.
cord-263277-m4too6ob	63	1	Namely	namely	RB
cord-263277-m4too6ob	63	2	,	,	,
cord-263277-m4too6ob	63	3	key	key	JJ
cord-263277-m4too6ob	63	4	influenza	influenza	NN
cord-263277-m4too6ob	63	5	-	-	HYPH
cord-263277-m4too6ob	63	6	specific	specific	JJ
cord-263277-m4too6ob	63	7	issues	issue	NNS
cord-263277-m4too6ob	63	8	of	of	IN
cord-263277-m4too6ob	63	9	interference	interference	NN
cord-263277-m4too6ob	63	10	due	due	IN
cord-263277-m4too6ob	63	11	to	to	IN
cord-263277-m4too6ob	63	12	pre	pre	JJ
cord-263277-m4too6ob	63	13	-	-	JJ
cord-263277-m4too6ob	63	14	existent	existent	JJ
cord-263277-m4too6ob	63	15	immunity	immunity	NN
cord-263277-m4too6ob	63	16	and	and	CC
cord-263277-m4too6ob	63	17	overall	overall	JJ
cord-263277-m4too6ob	63	18	poor	poor	JJ
cord-263277-m4too6ob	63	19	responsiveness	responsiveness	NN
cord-263277-m4too6ob	63	20	to	to	IN
cord-263277-m4too6ob	63	21	vaccines	vaccine	NNS
cord-263277-m4too6ob	63	22	in	in	IN
cord-263277-m4too6ob	63	23	vulnerable	vulnerable	JJ
cord-263277-m4too6ob	63	24	individuals	individual	NNS
cord-263277-m4too6ob	63	25	(	(	-LRB-
cord-263277-m4too6ob	63	26	e.g.	e.g.	RB
cord-263277-m4too6ob	63	27	,	,	,
cord-263277-m4too6ob	64	1	the	the	DT
cord-263277-m4too6ob	64	2	elderly	elderly	JJ
cord-263277-m4too6ob	64	3	,	,	,
cord-263277-m4too6ob	64	4	the	the	DT
cord-263277-m4too6ob	64	5	very	very	RB
cord-263277-m4too6ob	64	6	young	young	JJ
cord-263277-m4too6ob	64	7	,	,	,
cord-263277-m4too6ob	64	8	those	those	DT
cord-263277-m4too6ob	64	9	affected	affect	VBN
cord-263277-m4too6ob	64	10	by	by	IN
cord-263277-m4too6ob	64	11	co	co	NNS
cord-263277-m4too6ob	64	12	-	-	NNS
cord-263277-m4too6ob	64	13	morbidities	morbidity	NNS
cord-263277-m4too6ob	64	14	)	)	-RRB-
cord-263277-m4too6ob	64	15	often	often	RB
cord-263277-m4too6ob	64	16	result	result	VBP
cord-263277-m4too6ob	64	17	in	in	IN
cord-263277-m4too6ob	64	18	unpredictable	unpredictable	JJ
cord-263277-m4too6ob	64	19	poor	poor	JJ
cord-263277-m4too6ob	64	20	responsiveness	responsiveness	NN
cord-263277-m4too6ob	64	21	to	to	IN
cord-263277-m4too6ob	64	22	vaccination	vaccination	NN
cord-263277-m4too6ob	64	23	.	.	.
cord-263277-m4too6ob	65	1	Therefore	therefore	RB
cord-263277-m4too6ob	65	2	,	,	,
cord-263277-m4too6ob	65	3	the	the	DT
cord-263277-m4too6ob	65	4	problem	problem	NN
cord-263277-m4too6ob	65	5	of	of	IN
cord-263277-m4too6ob	65	6	poor	poor	JJ
cord-263277-m4too6ob	65	7	protection	protection	NN
cord-263277-m4too6ob	65	8	against	against	IN
cord-263277-m4too6ob	65	9	influenza	influenza	NN
cord-263277-m4too6ob	65	10	infection	infection	NN
cord-263277-m4too6ob	65	11	post	post	NN
cord-263277-m4too6ob	65	12	vaccination	vaccination	NN
cord-263277-m4too6ob	65	13	is	be	VBZ
cord-263277-m4too6ob	65	14	,	,	,
cord-263277-m4too6ob	65	15	by	by	IN
cord-263277-m4too6ob	65	16	and	and	CC
cord-263277-m4too6ob	65	17	large	large	JJ
cord-263277-m4too6ob	65	18	,	,	,
cord-263277-m4too6ob	65	19	defined	define	VBN
cord-263277-m4too6ob	65	20	by	by	IN
cord-263277-m4too6ob	65	21	a	a	DT
cord-263277-m4too6ob	65	22	knowledge	knowledge	NN
cord-263277-m4too6ob	65	23	gap	gap	NN
cord-263277-m4too6ob	65	24	in	in	IN
cord-263277-m4too6ob	65	25	key	key	JJ
cord-263277-m4too6ob	65	26	aspects	aspect	NNS
cord-263277-m4too6ob	65	27	of	of	IN
cord-263277-m4too6ob	65	28	human	human	JJ
cord-263277-m4too6ob	65	29	immunology	immunology	NN
cord-263277-m4too6ob	65	30	,	,	,
cord-263277-m4too6ob	65	31	such	such	JJ
cord-263277-m4too6ob	65	32	as	as	IN
cord-263277-m4too6ob	65	33	the	the	DT
cord-263277-m4too6ob	65	34	underlying	underlie	VBG
cord-263277-m4too6ob	65	35	mechanisms	mechanism	NNS
cord-263277-m4too6ob	65	36	involved	involve	VBN
cord-263277-m4too6ob	65	37	in	in	IN
cord-263277-m4too6ob	65	38	poor	poor	JJ
cord-263277-m4too6ob	65	39	individual	individual	JJ
cord-263277-m4too6ob	65	40	responsiveness	responsiveness	NN
cord-263277-m4too6ob	65	41	,	,	,
cord-263277-m4too6ob	65	42	and	and	CC
cord-263277-m4too6ob	65	43	how	how	WRB
cord-263277-m4too6ob	65	44	to	to	TO
cord-263277-m4too6ob	65	45	tailor	tailor	VB
cord-263277-m4too6ob	65	46	vaccines	vaccine	NNS
cord-263277-m4too6ob	65	47	according	accord	VBG
cord-263277-m4too6ob	65	48	to	to	IN
cord-263277-m4too6ob	65	49	the	the	DT
cord-263277-m4too6ob	65	50	needs	need	NNS
cord-263277-m4too6ob	65	51	of	of	IN
cord-263277-m4too6ob	65	52	subpopulation	subpopulation	NN
cord-263277-m4too6ob	65	53	groups	group	NNS
cord-263277-m4too6ob	65	54	to	to	TO
cord-263277-m4too6ob	65	55	generate	generate	VB
cord-263277-m4too6ob	65	56	broadly	broadly	RB
cord-263277-m4too6ob	65	57	protective	protective	JJ
cord-263277-m4too6ob	65	58	and	and	CC
cord-263277-m4too6ob	65	59	long	long	RB
cord-263277-m4too6ob	65	60	-	-	HYPH
cord-263277-m4too6ob	65	61	lasting	last	VBG
cord-263277-m4too6ob	65	62	immunity	immunity	NN
cord-263277-m4too6ob	65	63	.	.	.
cord-263277-m4too6ob	66	1	This	this	DT
cord-263277-m4too6ob	66	2	current	current	JJ
cord-263277-m4too6ob	66	3	knowledge	knowledge	NN
cord-263277-m4too6ob	66	4	gap	gap	NN
cord-263277-m4too6ob	66	5	can	can	MD
cord-263277-m4too6ob	66	6	be	be	VB
cord-263277-m4too6ob	66	7	addressed	address	VBN
cord-263277-m4too6ob	66	8	by	by	IN
cord-263277-m4too6ob	66	9	performing	perform	VBG
cord-263277-m4too6ob	66	10	comprehensive	comprehensive	JJ
cord-263277-m4too6ob	66	11	and	and	CC
cord-263277-m4too6ob	66	12	standardized	standardized	JJ
cord-263277-m4too6ob	66	13	profiling	profiling	NN
cord-263277-m4too6ob	66	14	at	at	IN
cord-263277-m4too6ob	66	15	baseline	baseline	NN
cord-263277-m4too6ob	66	16	and	and	CC
cord-263277-m4too6ob	66	17	post	post	NN
cord-263277-m4too6ob	66	18	immunization	immunization	NN
cord-263277-m4too6ob	66	19	of	of	IN
cord-263277-m4too6ob	66	20	responders	responder	NNS
cord-263277-m4too6ob	66	21	and	and	CC
cord-263277-m4too6ob	66	22	non	non	NNS
cord-263277-m4too6ob	66	23	-	-	NNS
cord-263277-m4too6ob	66	24	responders	responder	NNS
cord-263277-m4too6ob	66	25	to	to	IN
cord-263277-m4too6ob	66	26	influenza	influenza	NN
cord-263277-m4too6ob	66	27	vaccination	vaccination	NN
cord-263277-m4too6ob	66	28	in	in	IN
cord-263277-m4too6ob	66	29	different	different	JJ
cord-263277-m4too6ob	66	30	age	age	NN
cord-263277-m4too6ob	66	31	groups	group	NNS
cord-263277-m4too6ob	66	32	,	,	,
cord-263277-m4too6ob	66	33	both	both	DT
cord-263277-m4too6ob	66	34	in	in	IN
cord-263277-m4too6ob	66	35	healthy	healthy	JJ
cord-263277-m4too6ob	66	36	individuals	individual	NNS
cord-263277-m4too6ob	66	37	as	as	RB
cord-263277-m4too6ob	66	38	well	well	RB
cord-263277-m4too6ob	66	39	as	as	IN
cord-263277-m4too6ob	66	40	in	in	IN
cord-263277-m4too6ob	66	41	those	those	DT
cord-263277-m4too6ob	66	42	affected	affect	VBN
cord-263277-m4too6ob	66	43	by	by	IN
cord-263277-m4too6ob	66	44	co	co	NNS
cord-263277-m4too6ob	66	45	-	-	NNS
cord-263277-m4too6ob	66	46	morbidities	morbidity	NNS
cord-263277-m4too6ob	66	47	known	know	VBN
cord-263277-m4too6ob	66	48	to	to	TO
cord-263277-m4too6ob	66	49	affect	affect	VB
cord-263277-m4too6ob	66	50	responses	response	NNS
cord-263277-m4too6ob	66	51	to	to	IN
cord-263277-m4too6ob	66	52	vaccination	vaccination	NN
cord-263277-m4too6ob	66	53	.	.	.
cord-263277-m4too6ob	67	1	The	the	DT
cord-263277-m4too6ob	67	2	in	in	IN
cord-263277-m4too6ob	67	3	-	-	HYPH
cord-263277-m4too6ob	67	4	depth	depth	NN
cord-263277-m4too6ob	67	5	analysis	analysis	NN
cord-263277-m4too6ob	67	6	and	and	CC
cord-263277-m4too6ob	67	7	comparison	comparison	NN
cord-263277-m4too6ob	67	8	of	of	IN
cord-263277-m4too6ob	67	9	the	the	DT
cord-263277-m4too6ob	67	10	obtained	obtain	VBN
cord-263277-m4too6ob	67	11	immunological	immunological	JJ
cord-263277-m4too6ob	67	12	and	and	CC
cord-263277-m4too6ob	67	13	molecular	molecular	JJ
cord-263277-m4too6ob	67	14	signatures	signature	NNS
cord-263277-m4too6ob	67	15	using	use	VBG
cord-263277-m4too6ob	67	16	artificial	artificial	JJ
cord-263277-m4too6ob	67	17	intelligence	intelligence	NN
cord-263277-m4too6ob	67	18	tools	tool	NNS
cord-263277-m4too6ob	67	19	will	will	MD
cord-263277-m4too6ob	67	20	enable	enable	VB
cord-263277-m4too6ob	67	21	the	the	DT
cord-263277-m4too6ob	67	22	identification	identification	NN
cord-263277-m4too6ob	67	23	of	of	IN
cord-263277-m4too6ob	67	24	the	the	DT
cord-263277-m4too6ob	67	25	putative	putative	JJ
cord-263277-m4too6ob	67	26	underlying	underlying	JJ
cord-263277-m4too6ob	67	27	mechanisms	mechanism	NNS
cord-263277-m4too6ob	67	28	.	.	.
cord-263277-m4too6ob	68	1	These	these	DT
cord-263277-m4too6ob	68	2	mechanisms	mechanism	NNS
cord-263277-m4too6ob	68	3	will	will	MD
cord-263277-m4too6ob	68	4	provide	provide	VB
cord-263277-m4too6ob	68	5	intervention	intervention	NN
cord-263277-m4too6ob	68	6	targets	target	NNS
cord-263277-m4too6ob	68	7	to	to	TO
cord-263277-m4too6ob	68	8	develop	develop	VB
cord-263277-m4too6ob	68	9	more	more	RBR
cord-263277-m4too6ob	68	10	efficient	efficient	JJ
cord-263277-m4too6ob	68	11	tailored	tailor	VBN
cord-263277-m4too6ob	68	12	vaccination	vaccination	NN
cord-263277-m4too6ob	68	13	strategies	strategy	NNS
cord-263277-m4too6ob	68	14	,	,	,
cord-263277-m4too6ob	68	15	as	as	RB
cord-263277-m4too6ob	68	16	well	well	RB
cord-263277-m4too6ob	68	17	as	as	IN
cord-263277-m4too6ob	68	18	potential	potential	JJ
cord-263277-m4too6ob	68	19	predictive	predictive	JJ
cord-263277-m4too6ob	68	20	biomarkers	biomarker	NNS
cord-263277-m4too6ob	68	21	of	of	IN
cord-263277-m4too6ob	68	22	responsiveness	responsiveness	NN
cord-263277-m4too6ob	68	23	to	to	TO
cord-263277-m4too6ob	68	24	develop	develop	VB
cord-263277-m4too6ob	68	25	innovative	innovative	JJ
cord-263277-m4too6ob	68	26	diagnostics	diagnostic	NNS
cord-263277-m4too6ob	68	27	for	for	IN
cord-263277-m4too6ob	68	28	the	the	DT
cord-263277-m4too6ob	68	29	stratification	stratification	NN
cord-263277-m4too6ob	68	30	and	and	CC
cord-263277-m4too6ob	68	31	follow	follow	NN
cord-263277-m4too6ob	68	32	-	-	HYPH
cord-263277-m4too6ob	68	33	up	up	NN
cord-263277-m4too6ob	68	34	of	of	IN
cord-263277-m4too6ob	68	35	vaccinees	vaccinee	NNS
cord-263277-m4too6ob	68	36	.	.	.
cord-263277-m4too6ob	69	1	Funding	funding	NN
cord-263277-m4too6ob	69	2	:	:	:
cord-263277-m4too6ob	70	1	This	this	DT
cord-263277-m4too6ob	70	2	work	work	NN
cord-263277-m4too6ob	70	3	was	be	VBD
cord-263277-m4too6ob	70	4	supported	support	VBN
cord-263277-m4too6ob	70	5	in	in	IN
cord-263277-m4too6ob	70	6	part	part	NN
cord-263277-m4too6ob	70	7	by	by	IN
cord-263277-m4too6ob	70	8	grants	grant	NNS
cord-263277-m4too6ob	70	9	from	from	IN
cord-263277-m4too6ob	70	10	the	the	DT
cord-263277-m4too6ob	70	11	EU	EU	NNP
cord-263277-m4too6ob	70	12	(	(	-LRB-
cord-263277-m4too6ob	70	13	TRANSVAC2	TRANSVAC2	NNP
cord-263277-m4too6ob	70	14	-	-	HYPH
cord-263277-m4too6ob	70	15	730964	730964	CD
cord-263277-m4too6ob	70	16	;	;	:
cord-263277-m4too6ob	70	17	INCENTIVE-874866	INCENTIVE-874866	NNP
cord-263277-m4too6ob	70	18	)	)	-RRB-
cord-263277-m4too6ob	70	19	.	.	.
cord-263277-m4too6ob	71	1	The	the	DT
cord-263277-m4too6ob	71	2	author	author	NN
cord-263277-m4too6ob	71	3	declares	declare	VBZ
cord-263277-m4too6ob	71	4	no	no	DT
cord-263277-m4too6ob	71	5	conflict	conflict	NN
cord-263277-m4too6ob	71	6	of	of	IN
cord-263277-m4too6ob	71	7	interest	interest	NN
cord-263277-m4too6ob	71	8	.	.	.
cord-263277-m4too6ob	72	1	Global	global	JJ
cord-263277-m4too6ob	72	2	seasonal	seasonal	JJ
cord-263277-m4too6ob	72	3	influenza	influenza	NN
cord-263277-m4too6ob	72	4	-	-	HYPH
cord-263277-m4too6ob	72	5	associated	associate	VBN
cord-263277-m4too6ob	72	6	mortality	mortality	NN
cord-263277-m4too6ob	72	7	collaborator	collaborator	NN
cord-263277-m4too6ob	72	8	network	network	NN
cord-263277-m4too6ob	72	9	.	.	.
cord-263277-m4too6ob	73	1	Estimates	estimate	NNS
cord-263277-m4too6ob	73	2	of	of	IN
cord-263277-m4too6ob	73	3	global	global	JJ
cord-263277-m4too6ob	73	4	seasonal	seasonal	JJ
cord-263277-m4too6ob	73	5	influenza	influenza	NN
cord-263277-m4too6ob	73	6	-	-	HYPH
cord-263277-m4too6ob	73	7	associated	associate	VBN
cord-263277-m4too6ob	73	8	respiratory	respiratory	JJ
cord-263277-m4too6ob	73	9	mortality	mortality	NN
cord-263277-m4too6ob	73	10	:	:	:
cord-263277-m4too6ob	73	11	A	a	DT
cord-263277-m4too6ob	73	12	modelling	modelling	NN
cord-263277-m4too6ob	73	13	study	study	NN
cord-263277-m4too6ob	73	14	Drugs	drug	NNS
cord-263277-m4too6ob	73	15	for	for	IN
cord-263277-m4too6ob	73	16	influenza	influenza	NN
cord-263277-m4too6ob	73	17	treatment	treatment	NN
cord-263277-m4too6ob	74	1	:	:	:
cord-263277-m4too6ob	74	2	Is	be	VBZ
cord-263277-m4too6ob	74	3	there	there	EX
cord-263277-m4too6ob	74	4	significant	significant	JJ
cord-263277-m4too6ob	74	5	news	news	NN
cord-263277-m4too6ob	74	6	?	?	.
cord-263277-m4too6ob	75	1	Front	Front	NNP
cord-263277-m4too6ob	75	2	Factors	Factors	NNPS
cord-263277-m4too6ob	75	3	that	that	WDT
cord-263277-m4too6ob	75	4	influence	influence	VBP
cord-263277-m4too6ob	75	5	the	the	DT
cord-263277-m4too6ob	75	6	immune	immune	JJ
cord-263277-m4too6ob	75	7	response	response	NN
cord-263277-m4too6ob	75	8	to	to	IN
cord-263277-m4too6ob	75	9	vaccination	vaccination	NN
cord-263277-m4too6ob	75	10	Immunogenicity	Immunogenicity	NNP
cord-263277-m4too6ob	75	11	and	and	CC
cord-263277-m4too6ob	75	12	safety	safety	NN
cord-263277-m4too6ob	75	13	of	of	IN
cord-263277-m4too6ob	75	14	an	an	DT
cord-263277-m4too6ob	75	15	adjuvanted	adjuvanted	JJ
cord-263277-m4too6ob	75	16	influenza	influenza	NN
cord-263277-m4too6ob	75	17	vaccine	vaccine	NN
cord-263277-m4too6ob	75	18	in	in	IN
cord-263277-m4too6ob	75	19	patients	patient	NNS
cord-263277-m4too6ob	75	20	with	with	IN
cord-263277-m4too6ob	75	21	decompensated	decompensated	JJ
cord-263277-m4too6ob	75	22	cirrhosis	cirrhosis	NN
cord-263277-m4too6ob	75	23	Humoral	Humoral	NNP
cord-263277-m4too6ob	75	24	immune	immune	JJ
cord-263277-m4too6ob	75	25	response	response	NN
cord-263277-m4too6ob	75	26	to	to	IN
cord-263277-m4too6ob	75	27	influenza	influenza	NN
cord-263277-m4too6ob	75	28	vaccination	vaccination	NN
cord-263277-m4too6ob	75	29	in	in	IN
cord-263277-m4too6ob	75	30	patients	patient	NNS
cord-263277-m4too6ob	75	31	from	from	IN
cord-263277-m4too6ob	75	32	high	high	JJ
cord-263277-m4too6ob	75	33	risk	risk	NN
cord-263277-m4too6ob	75	34	groups	group	NNS
cord-263277-m4too6ob	75	35	Efforts	effort	NNS
cord-263277-m4too6ob	75	36	to	to	TO
cord-263277-m4too6ob	75	37	improve	improve	VB
cord-263277-m4too6ob	75	38	the	the	DT
cord-263277-m4too6ob	75	39	seasonal	seasonal	JJ
cord-263277-m4too6ob	75	40	influenza	influenza	NN
cord-263277-m4too6ob	75	41	vaccine	vaccine	NN
cord-263277-m4too6ob	75	42	The	the	DT
cord-263277-m4too6ob	75	43	2015	2015	CD
cord-263277-m4too6ob	75	44	global	global	JJ
cord-263277-m4too6ob	75	45	production	production	NN
cord-263277-m4too6ob	75	46	capacity	capacity	NN
cord-263277-m4too6ob	75	47	of	of	IN
cord-263277-m4too6ob	75	48	seasonal	seasonal	JJ
cord-263277-m4too6ob	75	49	and	and	CC
cord-263277-m4too6ob	75	50	pandemic	pandemic	NN
cord-263277-m4too6ob	75	51	influenza	influenza	NN
cord-263277-m4too6ob	75	52	vaccine	vaccine	NN
cord-263277-m4too6ob	76	1	Molecular	molecular	JJ
cord-263277-m4too6ob	76	2	changes	change	NNS
cord-263277-m4too6ob	76	3	associated	associate	VBN
cord-263277-m4too6ob	76	4	with	with	IN
cord-263277-m4too6ob	76	5	adaptation	adaptation	NN
cord-263277-m4too6ob	76	6	of	of	IN
cord-263277-m4too6ob	76	7	human	human	JJ
cord-263277-m4too6ob	76	8	influenza	influenza	NN
cord-263277-m4too6ob	76	9	A	a	DT
cord-263277-m4too6ob	76	10	virus	virus	NN
cord-263277-m4too6ob	76	11	in	in	IN
cord-263277-m4too6ob	76	12	embryonated	embryonate	VBN
cord-263277-m4too6ob	76	13	chicken	chicken	NN
cord-263277-m4too6ob	76	14	eggs	egg	NNS
cord-263277-m4too6ob	77	1	The	the	DT
cord-263277-m4too6ob	77	2	characteristics	characteristic	NNS
cord-263277-m4too6ob	77	3	and	and	CC
cord-263277-m4too6ob	77	4	antigenic	antigenic	JJ
cord-263277-m4too6ob	77	5	properties	property	NNS
cord-263277-m4too6ob	77	6	of	of	IN
cord-263277-m4too6ob	77	7	recently	recently	RB
cord-263277-m4too6ob	77	8	emerged	emerge	VBD
cord-263277-m4too6ob	77	9	subclade	subclade	NNP
cord-263277-m4too6ob	77	10	3c.3a	3c.3a	CD
cord-263277-m4too6ob	77	11	and	and	CC
cord-263277-m4too6ob	77	12	3c.2a	3c.2a	CD
cord-263277-m4too6ob	77	13	human	human	JJ
cord-263277-m4too6ob	77	14	influenza	influenza	NN
cord-263277-m4too6ob	77	15	A	A	NNP
cord-263277-m4too6ob	77	16	(	(	-LRB-
cord-263277-m4too6ob	77	17	H3N2	H3N2	NNP
cord-263277-m4too6ob	77	18	)	)	-RRB-
cord-263277-m4too6ob	77	19	viruses	virus	NNS
cord-263277-m4too6ob	77	20	passaged	passage	VBN
cord-263277-m4too6ob	77	21	in	in	IN
cord-263277-m4too6ob	77	22	mdck	mdck	NNP
cord-263277-m4too6ob	77	23	cells	cell	NNS
cord-263277-m4too6ob	77	24	.	.	.
cord-263277-m4too6ob	78	1	Influenza	Influenza	NNP
cord-263277-m4too6ob	78	2	Other	other	JJ
cord-263277-m4too6ob	78	3	Respir	Respir	NNP
cord-263277-m4too6ob	78	4	Rationally	rationally	RB
cord-263277-m4too6ob	78	5	designed	design	VBD
cord-263277-m4too6ob	78	6	influenza	influenza	NN
cord-263277-m4too6ob	78	7	virus	virus	NN
cord-263277-m4too6ob	78	8	vaccines	vaccine	NNS
cord-263277-m4too6ob	78	9	that	that	WDT
cord-263277-m4too6ob	78	10	are	be	VBP
cord-263277-m4too6ob	78	11	antigenically	antigenically	RB
cord-263277-m4too6ob	78	12	stable	stable	JJ
cord-263277-m4too6ob	78	13	during	during	IN
cord-263277-m4too6ob	78	14	growth	growth	NN
cord-263277-m4too6ob	78	15	in	in	IN
cord-263277-m4too6ob	78	16	eggs	egg	NNS
cord-263277-m4too6ob	78	17	Harnessing	harness	VBG
cord-263277-m4too6ob	78	18	the	the	DT
cord-263277-m4too6ob	78	19	power	power	NN
cord-263277-m4too6ob	78	20	of	of	IN
cord-263277-m4too6ob	78	21	T	T	NNP
cord-263277-m4too6ob	78	22	cells	cell	NNS
cord-263277-m4too6ob	78	23	:	:	:
cord-263277-m4too6ob	78	24	The	the	DT
cord-263277-m4too6ob	78	25	promising	promising	JJ
cord-263277-m4too6ob	78	26	hope	hope	NN
cord-263277-m4too6ob	78	27	for	for	IN
cord-263277-m4too6ob	78	28	a	a	DT
cord-263277-m4too6ob	78	29	universal	universal	JJ
cord-263277-m4too6ob	78	30	influenza	influenza	NN
cord-263277-m4too6ob	78	31	vaccine	vaccine	NN
cord-263277-m4too6ob	78	32	Protective	protective	JJ
cord-263277-m4too6ob	78	33	efficacy	efficacy	NN
cord-263277-m4too6ob	78	34	of	of	IN
cord-263277-m4too6ob	78	35	in	in	FW
cord-263277-m4too6ob	78	36	vitro	vitro	FW
cord-263277-m4too6ob	78	37	synthesized	synthesize	VBN
cord-263277-m4too6ob	78	38	,	,	,
cord-263277-m4too6ob	78	39	specific	specific	JJ
cord-263277-m4too6ob	78	40	mrna	mrna	NNP
cord-263277-m4too6ob	78	41	vaccines	vaccine	NNS
cord-263277-m4too6ob	78	42	against	against	IN
cord-263277-m4too6ob	78	43	influenza	influenza	NN
cord-263277-m4too6ob	78	44	a	a	DT
cord-263277-m4too6ob	78	45	virus	virus	NN
cord-263277-m4too6ob	78	46	infection	infection	NN
cord-263277-m4too6ob	78	47	Preclinical	preclinical	JJ
cord-263277-m4too6ob	78	48	and	and	CC
cord-263277-m4too6ob	78	49	clinical	clinical	JJ
cord-263277-m4too6ob	78	50	demonstration	demonstration	NN
cord-263277-m4too6ob	78	51	of	of	IN
cord-263277-m4too6ob	78	52	immunogenicity	immunogenicity	NN
cord-263277-m4too6ob	78	53	by	by	IN
cord-263277-m4too6ob	78	54	mRNA	mRNA	NNP
cord-263277-m4too6ob	78	55	vaccines	vaccine	NNS
cord-263277-m4too6ob	78	56	against	against	IN
cord-263277-m4too6ob	78	57	H10N8	H10N8	NNP
cord-263277-m4too6ob	78	58	and	and	CC
cord-263277-m4too6ob	79	1	H7N9	H7N9	NNP
cord-263277-m4too6ob	79	2	influenza	influenza	NN
cord-263277-m4too6ob	79	3	viruses	virus	NNS
cord-263277-m4too6ob	80	1	Phase	phase	NN
cord-263277-m4too6ob	80	2	1/2	1/2	CD
cord-263277-m4too6ob	80	3	study	study	NN
cord-263277-m4too6ob	80	4	to	to	TO
cord-263277-m4too6ob	80	5	describe	describe	VB
cord-263277-m4too6ob	80	6	the	the	DT
cord-263277-m4too6ob	80	7	safety	safety	NN
cord-263277-m4too6ob	80	8	and	and	CC
cord-263277-m4too6ob	80	9	immunogenicity	immunogenicity	NN
cord-263277-m4too6ob	80	10	of	of	IN
cord-263277-m4too6ob	80	11	a	a	DT
cord-263277-m4too6ob	80	12	COVID-19	COVID-19	NNP
cord-263277-m4too6ob	80	13	RNA	RNA	NNP
cord-263277-m4too6ob	80	14	vaccine	vaccine	NN
cord-263277-m4too6ob	80	15	candidate	candidate	NN
cord-263277-m4too6ob	80	16	(	(	-LRB-
cord-263277-m4too6ob	80	17	BNT162b1	BNT162b1	NNP
cord-263277-m4too6ob	80	18	)	)	-RRB-
cord-263277-m4too6ob	80	19	in	in	IN
cord-263277-m4too6ob	80	20	adults	adult	NNS
cord-263277-m4too6ob	80	21	18	18	CD
cord-263277-m4too6ob	80	22	to	to	TO
cord-263277-m4too6ob	80	23	55	55	CD
cord-263277-m4too6ob	80	24	years	year	NNS
cord-263277-m4too6ob	80	25	of	of	IN
cord-263277-m4too6ob	80	26	age	age	NN
cord-263277-m4too6ob	81	1	:	:	:
cord-263277-m4too6ob	81	2	Interim	interim	JJ
cord-263277-m4too6ob	81	3	report	report	NN
cord-263277-m4too6ob	82	1	An	an	DT
cord-263277-m4too6ob	82	2	mRNA	mrna	NN
cord-263277-m4too6ob	82	3	vaccine	vaccine	NN
cord-263277-m4too6ob	82	4	against	against	IN
cord-263277-m4too6ob	82	5	SARS	SARS	NNP
cord-263277-m4too6ob	82	6	-	-	HYPH
cord-263277-m4too6ob	82	7	CoV-2-preliminary	CoV-2-preliminary	NNP
cord-263277-m4too6ob	82	8	report	report	VBP
cord-263277-m4too6ob	82	9	New	new	JJ
cord-263277-m4too6ob	82	10	kids	kid	NNS
cord-263277-m4too6ob	82	11	on	on	IN
cord-263277-m4too6ob	82	12	the	the	DT
cord-263277-m4too6ob	82	13	block	block	NN
cord-263277-m4too6ob	82	14	:	:	:
cord-263277-m4too6ob	83	1	RNA	RNA	NNP
cord-263277-m4too6ob	83	2	-	-	HYPH
cord-263277-m4too6ob	83	3	based	base	VBN
cord-263277-m4too6ob	83	4	influenza	influenza	NN
cord-263277-m4too6ob	83	5	virus	virus	NN
cord-263277-m4too6ob	83	6	vaccines	vaccine	NNS
cord-263277-m4too6ob	83	7	WHO	who	WP
cord-263277-m4too6ob	83	8	Preferred	Preferred	NNP
cord-263277-m4too6ob	83	9	Product	Product	NNP
cord-263277-m4too6ob	83	10	Characteristics	Characteristics	NNP
cord-263277-m4too6ob	83	11	for	for	IN
cord-263277-m4too6ob	83	12	Next	Next	NNP
cord-263277-m4too6ob	83	13	-	-	HYPH
cord-263277-m4too6ob	83	14	Generation	Generation	NNP
cord-263277-m4too6ob	83	15	Influenza	Influenza	NNP
cord-263277-m4too6ob	83	16	Vaccines	Vaccines	NNPS
cord-263277-m4too6ob	83	17	;	;	:
cord-263277-m4too6ob	83	18	World	World	NNP
cord-263277-m4too6ob	83	19	Health	Health	NNP
cord-263277-m4too6ob	83	20	Organization	Organization	NNP
cord-263277-m4too6ob	83	21	Immune	Immune	NNP
cord-263277-m4too6ob	83	22	history	history	NN
cord-263277-m4too6ob	83	23	and	and	CC
cord-263277-m4too6ob	83	24	influenza	influenza	NN
cord-263277-m4too6ob	83	25	vaccine	vaccine	NN
cord-263277-m4too6ob	83	26	effectiveness	effectiveness	NN
cord-263277-m4too6ob	83	27	Roads	road	NNS
cord-263277-m4too6ob	83	28	to	to	IN
cord-263277-m4too6ob	83	29	advanced	advanced	JJ
cord-263277-m4too6ob	83	30	vaccines	vaccine	NNS
cord-263277-m4too6ob	83	31	:	:	:
cord-263277-m4too6ob	83	32	Influenza	influenza	NN
cord-263277-m4too6ob	83	33	case	case	NN
cord-263277-m4too6ob	83	34	study	study	NN
cord-263277-m4too6ob	84	1	A	a	DT
cord-263277-m4too6ob	84	2	computationally	computationally	RB
cord-263277-m4too6ob	84	3	optimized	optimize	VBN
cord-263277-m4too6ob	84	4	broadly	broadly	RB
cord-263277-m4too6ob	84	5	reactive	reactive	JJ
cord-263277-m4too6ob	84	6	antigen	antigen	NN
cord-263277-m4too6ob	84	7	(	(	-LRB-
cord-263277-m4too6ob	84	8	COBRA	COBRA	NNP
cord-263277-m4too6ob	84	9	)	)	-RRB-
cord-263277-m4too6ob	84	10	based	base	VBN
cord-263277-m4too6ob	84	11	H5N1	H5N1	NNP
cord-263277-m4too6ob	84	12	VLP	VLP	NNP
cord-263277-m4too6ob	84	13	vaccine	vaccine	NN
cord-263277-m4too6ob	84	14	elicits	elicit	VBZ
cord-263277-m4too6ob	84	15	broadly	broadly	RB
cord-263277-m4too6ob	84	16	reactive	reactive	JJ
cord-263277-m4too6ob	84	17	antibodies	antibody	NNS
cord-263277-m4too6ob	84	18	in	in	IN
cord-263277-m4too6ob	84	19	mice	mouse	NNS
cord-263277-m4too6ob	84	20	and	and	CC
cord-263277-m4too6ob	84	21	ferrets	ferret	NNS
cord-263277-m4too6ob	84	22	Effectiveness	Effectiveness	NNP
cord-263277-m4too6ob	84	23	of	of	IN
cord-263277-m4too6ob	84	24	MF59-adjuvanted	MF59-adjuvanted	NNP
cord-263277-m4too6ob	84	25	seasonal	seasonal	JJ
cord-263277-m4too6ob	84	26	influenza	influenza	NN
cord-263277-m4too6ob	84	27	vaccine	vaccine	NN
cord-263277-m4too6ob	84	28	in	in	IN
cord-263277-m4too6ob	84	29	the	the	DT
cord-263277-m4too6ob	84	30	elderly	elderly	JJ
cord-263277-m4too6ob	84	31	:	:	:
cord-263277-m4too6ob	84	32	A	a	DT
cord-263277-m4too6ob	84	33	systematic	systematic	JJ
cord-263277-m4too6ob	84	34	review	review	NN
cord-263277-m4too6ob	84	35	and	and	CC
cord-263277-m4too6ob	84	36	meta	meta	NNP
cord-263277-m4too6ob	84	37	-	-	HYPH
cord-263277-m4too6ob	84	38	analysis	analysis	NN
cord-263277-m4too6ob	85	1	Seeking	seek	VBG
cord-263277-m4too6ob	85	2	help	help	NN
cord-263277-m4too6ob	85	3	:	:	:
cord-263277-m4too6ob	85	4	B	b	NN
cord-263277-m4too6ob	85	5	cells	cell	NNS
cord-263277-m4too6ob	85	6	adapting	adapt	VBG
cord-263277-m4too6ob	85	7	to	to	IN
cord-263277-m4too6ob	85	8	flu	flu	NN
cord-263277-m4too6ob	85	9	variability	variability	NN
cord-263277-m4too6ob	85	10	Mucosal	Mucosal	NNP
cord-263277-m4too6ob	85	11	administration	administration	NN
cord-263277-m4too6ob	85	12	of	of	IN
cord-263277-m4too6ob	85	13	cycle	cycle	NN
cord-263277-m4too6ob	85	14	-	-	HYPH
cord-263277-m4too6ob	85	15	di	di	NN
cord-263277-m4too6ob	85	16	-	-	HYPH
cord-263277-m4too6ob	85	17	nucleotide	nucleotide	RB
cord-263277-m4too6ob	85	18	-	-	HYPH
cord-263277-m4too6ob	85	19	adjuvanted	adjuvante	VBN
cord-263277-m4too6ob	85	20	virosomes	virosome	NNS
cord-263277-m4too6ob	85	21	efficiently	efficiently	RB
cord-263277-m4too6ob	85	22	induces	induce	VBZ
cord-263277-m4too6ob	85	23	protection	protection	NN
cord-263277-m4too6ob	85	24	against	against	IN
cord-263277-m4too6ob	85	25	influenza	influenza	NN
cord-263277-m4too6ob	85	26	H5N1	H5N1	NNP
cord-263277-m4too6ob	85	27	in	in	IN
cord-263277-m4too6ob	85	28	mice	mouse	NNS
cord-263277-m4too6ob	86	1	The	the	DT
cord-263277-m4too6ob	86	2	human	human	JJ
cord-263277-m4too6ob	86	3	viral	viral	JJ
cord-263277-m4too6ob	86	4	challenge	challenge	NN
cord-263277-m4too6ob	86	5	model	model	NN
cord-263277-m4too6ob	86	6	:	:	:
cord-263277-m4too6ob	86	7	Accelerating	accelerate	VBG
cord-263277-m4too6ob	86	8	the	the	DT
cord-263277-m4too6ob	86	9	evaluation	evaluation	NN
cord-263277-m4too6ob	86	10	of	of	IN
cord-263277-m4too6ob	86	11	respiratory	respiratory	JJ
cord-263277-m4too6ob	86	12	antivirals	antiviral	NNS
cord-263277-m4too6ob	86	13	,	,	,
cord-263277-m4too6ob	86	14	vaccines	vaccine	NNS
cord-263277-m4too6ob	86	15	and	and	CC
cord-263277-m4too6ob	86	16	novel	novel	NN
cord-263277-m4too6ob	86	17	diagnostics	diagnostic	NNS
cord-263277-m4too6ob	86	18	Vaccines	Vaccines	NNP
cord-263277-m4too6ob	86	19	2020	2020	CD
cord-263277-m4too6ob	86	20	,	,	,
cord-263277-m4too6ob	86	21	8	8	CD
cord-263277-m4too6ob	86	22	,	,	,
cord-263277-m4too6ob	86	23	464	464	CD
cord-263277-m4too6ob	86	24	 	 	_SP