id	sid	tid	token	lemma	pos
cord-290004-v3ruj5bq	1	1	key	key	JJ
cord-290004-v3ruj5bq	2	1	:	:	:
cord-290004-v3ruj5bq	2	2	cord-290004-v3ruj5bq	cord-290004-v3ruj5bq	NNP
cord-290004-v3ruj5bq	2	3	authors	author	NNS
cord-290004-v3ruj5bq	2	4	:	:	:
cord-290004-v3ruj5bq	2	5	Madsen	Madsen	NNP
cord-290004-v3ruj5bq	2	6	,	,	,
cord-290004-v3ruj5bq	2	7	Anders	Anders	NNP
cord-290004-v3ruj5bq	2	8	;	;	:
cord-290004-v3ruj5bq	2	9	Cox	Cox	NNP
cord-290004-v3ruj5bq	2	10	,	,	,
cord-290004-v3ruj5bq	2	11	Rebecca	Rebecca	NNP
cord-290004-v3ruj5bq	2	12	Jane	Jane	NNP
cord-290004-v3ruj5bq	3	1	title	title	NN
cord-290004-v3ruj5bq	3	2	:	:	:
cord-290004-v3ruj5bq	3	3	Prospects	prospect	NNS
cord-290004-v3ruj5bq	3	4	and	and	CC
cord-290004-v3ruj5bq	3	5	Challenges	challenge	NNS
cord-290004-v3ruj5bq	3	6	in	in	IN
cord-290004-v3ruj5bq	3	7	the	the	DT
cord-290004-v3ruj5bq	3	8	Development	Development	NNP
cord-290004-v3ruj5bq	3	9	of	of	IN
cord-290004-v3ruj5bq	3	10	Universal	Universal	NNP
cord-290004-v3ruj5bq	3	11	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	3	12	Vaccines	Vaccines	NNPS
cord-290004-v3ruj5bq	3	13	date	date	NN
cord-290004-v3ruj5bq	3	14	:	:	:
cord-290004-v3ruj5bq	3	15	2020	2020	CD
cord-290004-v3ruj5bq	3	16	-	-	HYPH
cord-290004-v3ruj5bq	3	17	07	07	CD
cord-290004-v3ruj5bq	3	18	-	-	HYPH
cord-290004-v3ruj5bq	3	19	06	06	CD
cord-290004-v3ruj5bq	3	20	journal	journal	NN
cord-290004-v3ruj5bq	3	21	:	:	:
cord-290004-v3ruj5bq	3	22	Vaccines	Vaccines	NNP
cord-290004-v3ruj5bq	3	23	(	(	-LRB-
cord-290004-v3ruj5bq	3	24	Basel	Basel	NNP
cord-290004-v3ruj5bq	3	25	)	)	-RRB-
cord-290004-v3ruj5bq	3	26	DOI	DOI	NNP
cord-290004-v3ruj5bq	3	27	:	:	:
cord-290004-v3ruj5bq	4	1	10.3390	10.3390	CD
cord-290004-v3ruj5bq	4	2	/	/	SYM
cord-290004-v3ruj5bq	4	3	vaccines8030361	vaccines8030361	NNP
cord-290004-v3ruj5bq	4	4	sha	sha	NNP
cord-290004-v3ruj5bq	4	5	:	:	:
cord-290004-v3ruj5bq	4	6	54d278b9d232abfef73451afa830272d2989c179	54d278b9d232abfef73451afa830272d2989c179	CD
cord-290004-v3ruj5bq	4	7	doc_id	doc_id	CD
cord-290004-v3ruj5bq	4	8	:	:	:
cord-290004-v3ruj5bq	4	9	290004	290004	CD
cord-290004-v3ruj5bq	4	10	cord_uid	cord_uid	NNS
cord-290004-v3ruj5bq	4	11	:	:	:
cord-290004-v3ruj5bq	5	1	v3ruj5bq	v3ruj5bq	NNP
cord-290004-v3ruj5bq	5	2	Current	current	JJ
cord-290004-v3ruj5bq	5	3	influenza	influenza	NN
cord-290004-v3ruj5bq	5	4	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	5	5	offer	offer	VBP
cord-290004-v3ruj5bq	5	6	suboptimal	suboptimal	JJ
cord-290004-v3ruj5bq	5	7	protection	protection	NN
cord-290004-v3ruj5bq	5	8	and	and	CC
cord-290004-v3ruj5bq	5	9	depend	depend	VB
cord-290004-v3ruj5bq	5	10	on	on	IN
cord-290004-v3ruj5bq	5	11	annual	annual	JJ
cord-290004-v3ruj5bq	5	12	reformulation	reformulation	NN
cord-290004-v3ruj5bq	5	13	and	and	CC
cord-290004-v3ruj5bq	5	14	yearly	yearly	JJ
cord-290004-v3ruj5bq	5	15	administration	administration	NN
cord-290004-v3ruj5bq	5	16	.	.	.
cord-290004-v3ruj5bq	6	1	Vaccine	vaccine	NN
cord-290004-v3ruj5bq	6	2	technology	technology	NN
cord-290004-v3ruj5bq	6	3	has	have	VBZ
cord-290004-v3ruj5bq	6	4	rapidly	rapidly	RB
cord-290004-v3ruj5bq	6	5	advanced	advance	VBN
cord-290004-v3ruj5bq	6	6	during	during	IN
cord-290004-v3ruj5bq	6	7	the	the	DT
cord-290004-v3ruj5bq	6	8	last	last	JJ
cord-290004-v3ruj5bq	6	9	decade	decade	NN
cord-290004-v3ruj5bq	6	10	,	,	,
cord-290004-v3ruj5bq	6	11	facilitating	facilitate	VBG
cord-290004-v3ruj5bq	6	12	development	development	NN
cord-290004-v3ruj5bq	6	13	of	of	IN
cord-290004-v3ruj5bq	6	14	next	next	JJ
cord-290004-v3ruj5bq	6	15	-	-	HYPH
cord-290004-v3ruj5bq	6	16	generation	generation	NN
cord-290004-v3ruj5bq	6	17	influenza	influenza	NN
cord-290004-v3ruj5bq	6	18	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	6	19	that	that	WDT
cord-290004-v3ruj5bq	6	20	can	can	MD
cord-290004-v3ruj5bq	6	21	target	target	VB
cord-290004-v3ruj5bq	6	22	a	a	DT
cord-290004-v3ruj5bq	6	23	broader	broad	JJR
cord-290004-v3ruj5bq	6	24	range	range	NN
cord-290004-v3ruj5bq	6	25	of	of	IN
cord-290004-v3ruj5bq	6	26	influenza	influenza	NN
cord-290004-v3ruj5bq	6	27	viruses	virus	NNS
cord-290004-v3ruj5bq	6	28	.	.	.
cord-290004-v3ruj5bq	7	1	The	the	DT
cord-290004-v3ruj5bq	7	2	development	development	NN
cord-290004-v3ruj5bq	7	3	and	and	CC
cord-290004-v3ruj5bq	7	4	licensure	licensure	NN
cord-290004-v3ruj5bq	7	5	of	of	IN
cord-290004-v3ruj5bq	7	6	a	a	DT
cord-290004-v3ruj5bq	7	7	universal	universal	JJ
cord-290004-v3ruj5bq	7	8	influenza	influenza	NN
cord-290004-v3ruj5bq	7	9	vaccine	vaccine	NN
cord-290004-v3ruj5bq	7	10	could	could	MD
cord-290004-v3ruj5bq	7	11	provide	provide	VB
cord-290004-v3ruj5bq	7	12	a	a	DT
cord-290004-v3ruj5bq	7	13	game	game	NN
cord-290004-v3ruj5bq	7	14	changing	change	VBG
cord-290004-v3ruj5bq	7	15	option	option	NN
cord-290004-v3ruj5bq	7	16	for	for	IN
cord-290004-v3ruj5bq	7	17	the	the	DT
cord-290004-v3ruj5bq	7	18	control	control	NN
cord-290004-v3ruj5bq	7	19	of	of	IN
cord-290004-v3ruj5bq	7	20	influenza	influenza	NN
cord-290004-v3ruj5bq	7	21	by	by	IN
cord-290004-v3ruj5bq	7	22	protecting	protect	VBG
cord-290004-v3ruj5bq	7	23	against	against	IN
cord-290004-v3ruj5bq	7	24	all	all	DT
cord-290004-v3ruj5bq	7	25	influenza	influenza	NN
cord-290004-v3ruj5bq	7	26	A	a	NN
cord-290004-v3ruj5bq	7	27	and	and	CC
cord-290004-v3ruj5bq	7	28	B	b	NN
cord-290004-v3ruj5bq	7	29	viruses	virus	NNS
cord-290004-v3ruj5bq	7	30	.	.	.
cord-290004-v3ruj5bq	8	1	Here	here	RB
cord-290004-v3ruj5bq	8	2	we	-PRON-	PRP
cord-290004-v3ruj5bq	8	3	review	review	VBP
cord-290004-v3ruj5bq	8	4	important	important	JJ
cord-290004-v3ruj5bq	8	5	findings	finding	NNS
cord-290004-v3ruj5bq	8	6	and	and	CC
cord-290004-v3ruj5bq	8	7	considerations	consideration	NNS
cord-290004-v3ruj5bq	8	8	regarding	regard	VBG
cord-290004-v3ruj5bq	8	9	the	the	DT
cord-290004-v3ruj5bq	8	10	development	development	NN
cord-290004-v3ruj5bq	8	11	of	of	IN
cord-290004-v3ruj5bq	8	12	universal	universal	JJ
cord-290004-v3ruj5bq	8	13	influenza	influenza	NN
cord-290004-v3ruj5bq	8	14	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	8	15	and	and	CC
cord-290004-v3ruj5bq	8	16	what	what	WP
cord-290004-v3ruj5bq	8	17	we	-PRON-	PRP
cord-290004-v3ruj5bq	8	18	can	can	MD
cord-290004-v3ruj5bq	8	19	learn	learn	VB
cord-290004-v3ruj5bq	8	20	from	from	IN
cord-290004-v3ruj5bq	8	21	this	this	DT
cord-290004-v3ruj5bq	8	22	moving	move	VBG
cord-290004-v3ruj5bq	8	23	forward	forward	RB
cord-290004-v3ruj5bq	8	24	with	with	IN
cord-290004-v3ruj5bq	8	25	a	a	DT
cord-290004-v3ruj5bq	8	26	SARS	SARS	NNP
cord-290004-v3ruj5bq	8	27	-	-	HYPH
cord-290004-v3ruj5bq	8	28	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	8	29	vaccine	vaccine	NN
cord-290004-v3ruj5bq	8	30	design	design	NN
cord-290004-v3ruj5bq	8	31	.	.	.
cord-290004-v3ruj5bq	9	1	An	an	DT
cord-290004-v3ruj5bq	9	2	influenza	influenza	NN
cord-290004-v3ruj5bq	9	3	virus	virus	NN
cord-290004-v3ruj5bq	9	4	infection	infection	NN
cord-290004-v3ruj5bq	9	5	typically	typically	RB
cord-290004-v3ruj5bq	9	6	manifests	manifest	VBZ
cord-290004-v3ruj5bq	9	7	as	as	IN
cord-290004-v3ruj5bq	9	8	a	a	DT
cord-290004-v3ruj5bq	9	9	fever	fever	NN
cord-290004-v3ruj5bq	9	10	,	,	,
cord-290004-v3ruj5bq	9	11	sore	sore	JJ
cord-290004-v3ruj5bq	9	12	throat	throat	NN
cord-290004-v3ruj5bq	9	13	,	,	,
cord-290004-v3ruj5bq	9	14	cough	cough	NN
cord-290004-v3ruj5bq	9	15	,	,	,
cord-290004-v3ruj5bq	9	16	runny	runny	JJ
cord-290004-v3ruj5bq	9	17	nose	nose	NN
cord-290004-v3ruj5bq	9	18	,	,	,
cord-290004-v3ruj5bq	9	19	myalgia	myalgia	NN
cord-290004-v3ruj5bq	9	20	,	,	,
cord-290004-v3ruj5bq	9	21	and	and	CC
cord-290004-v3ruj5bq	9	22	headaches	headache	NNS
cord-290004-v3ruj5bq	9	23	.	.	.
cord-290004-v3ruj5bq	10	1	People	People	NNS
cord-290004-v3ruj5bq	10	2	in	in	IN
cord-290004-v3ruj5bq	10	3	certain	certain	JJ
cord-290004-v3ruj5bq	10	4	risk	risk	NN
cord-290004-v3ruj5bq	10	5	groups	group	NNS
cord-290004-v3ruj5bq	10	6	(	(	-LRB-
cord-290004-v3ruj5bq	10	7	the	the	DT
cord-290004-v3ruj5bq	10	8	elderly	elderly	JJ
cord-290004-v3ruj5bq	10	9	,	,	,
cord-290004-v3ruj5bq	10	10	children	child	NNS
cord-290004-v3ruj5bq	10	11	<	<	XX
cord-290004-v3ruj5bq	10	12	59	59	CD
cord-290004-v3ruj5bq	10	13	months	month	NNS
cord-290004-v3ruj5bq	10	14	of	of	IN
cord-290004-v3ruj5bq	10	15	age	age	NN
cord-290004-v3ruj5bq	10	16	,	,	,
cord-290004-v3ruj5bq	10	17	pregnant	pregnant	JJ
cord-290004-v3ruj5bq	10	18	women	woman	NNS
cord-290004-v3ruj5bq	10	19	,	,	,
cord-290004-v3ruj5bq	10	20	and	and	CC
cord-290004-v3ruj5bq	10	21	individuals	individual	NNS
cord-290004-v3ruj5bq	10	22	with	with	IN
cord-290004-v3ruj5bq	10	23	chronic	chronic	JJ
cord-290004-v3ruj5bq	10	24	conditions	condition	NNS
cord-290004-v3ruj5bq	10	25	)	)	-RRB-
cord-290004-v3ruj5bq	10	26	have	have	VBP
cord-290004-v3ruj5bq	10	27	a	a	DT
cord-290004-v3ruj5bq	10	28	higher	high	JJR
cord-290004-v3ruj5bq	10	29	chance	chance	NN
cord-290004-v3ruj5bq	10	30	of	of	IN
cord-290004-v3ruj5bq	10	31	developing	develop	VBG
cord-290004-v3ruj5bq	10	32	more	more	RBR
cord-290004-v3ruj5bq	10	33	severe	severe	JJ
cord-290004-v3ruj5bq	10	34	illness	illness	NN
cord-290004-v3ruj5bq	10	35	with	with	IN
cord-290004-v3ruj5bq	10	36	complications	complication	NNS
cord-290004-v3ruj5bq	10	37	such	such	JJ
cord-290004-v3ruj5bq	10	38	as	as	IN
cord-290004-v3ruj5bq	10	39	fulminant	fulminant	JJ
cord-290004-v3ruj5bq	10	40	pneumonia	pneumonia	NN
cord-290004-v3ruj5bq	10	41	.	.	.
cord-290004-v3ruj5bq	11	1	Seasonal	seasonal	JJ
cord-290004-v3ruj5bq	11	2	influenza	influenza	NN
cord-290004-v3ruj5bq	11	3	causes	cause	VBZ
cord-290004-v3ruj5bq	11	4	around	around	IN
cord-290004-v3ruj5bq	11	5	290,000	290,000	CD
cord-290004-v3ruj5bq	11	6	to	to	TO
cord-290004-v3ruj5bq	11	7	650,000	650,000	CD
cord-290004-v3ruj5bq	11	8	respiratory	respiratory	JJ
cord-290004-v3ruj5bq	11	9	deaths	death	NNS
cord-290004-v3ruj5bq	11	10	each	each	DT
cord-290004-v3ruj5bq	11	11	year	year	NN
cord-290004-v3ruj5bq	11	12	[	[	-LRB-
cord-290004-v3ruj5bq	11	13	1	1	CD
cord-290004-v3ruj5bq	11	14	]	]	-RRB-
cord-290004-v3ruj5bq	11	15	.	.	.
cord-290004-v3ruj5bq	12	1	However	however	RB
cord-290004-v3ruj5bq	12	2	,	,	,
cord-290004-v3ruj5bq	12	3	this	this	DT
cord-290004-v3ruj5bq	12	4	number	number	NN
cord-290004-v3ruj5bq	12	5	can	can	MD
cord-290004-v3ruj5bq	12	6	increase	increase	VB
cord-290004-v3ruj5bq	12	7	dramatically	dramatically	RB
cord-290004-v3ruj5bq	12	8	when	when	WRB
cord-290004-v3ruj5bq	12	9	,	,	,
cord-290004-v3ruj5bq	12	10	at	at	IN
cord-290004-v3ruj5bq	12	11	unpredictable	unpredictable	JJ
cord-290004-v3ruj5bq	12	12	intervals	interval	NNS
cord-290004-v3ruj5bq	12	13	,	,	,
cord-290004-v3ruj5bq	12	14	influenza	influenza	NN
cord-290004-v3ruj5bq	12	15	pandemics	pandemic	NNS
cord-290004-v3ruj5bq	12	16	occur	occur	VBP
cord-290004-v3ruj5bq	12	17	.	.	.
cord-290004-v3ruj5bq	13	1	These	these	DT
cord-290004-v3ruj5bq	13	2	global	global	JJ
cord-290004-v3ruj5bq	13	3	epidemics	epidemic	NNS
cord-290004-v3ruj5bq	13	4	are	be	VBP
cord-290004-v3ruj5bq	13	5	characterized	characterize	VBN
cord-290004-v3ruj5bq	13	6	by	by	IN
cord-290004-v3ruj5bq	13	7	the	the	DT
cord-290004-v3ruj5bq	13	8	emergence	emergence	NN
cord-290004-v3ruj5bq	13	9	of	of	IN
cord-290004-v3ruj5bq	13	10	a	a	DT
cord-290004-v3ruj5bq	13	11	novel	novel	JJ
cord-290004-v3ruj5bq	13	12	influenza	influenza	NN
cord-290004-v3ruj5bq	13	13	virus	virus	NN
cord-290004-v3ruj5bq	13	14	to	to	TO
cord-290004-v3ruj5bq	13	15	which	which	WDT
cord-290004-v3ruj5bq	13	16	most	most	JJS
cord-290004-v3ruj5bq	13	17	humans	human	NNS
cord-290004-v3ruj5bq	13	18	are	be	VBP
cord-290004-v3ruj5bq	13	19	immunologically	immunologically	RB
cord-290004-v3ruj5bq	13	20	naïve	naïve	JJ
cord-290004-v3ruj5bq	13	21	[	[	-LRB-
cord-290004-v3ruj5bq	13	22	2	2	CD
cord-290004-v3ruj5bq	13	23	]	]	-RRB-
cord-290004-v3ruj5bq	13	24	.	.	.
cord-290004-v3ruj5bq	14	1	The	the	DT
cord-290004-v3ruj5bq	14	2	emergence	emergence	NN
cord-290004-v3ruj5bq	14	3	of	of	IN
cord-290004-v3ruj5bq	14	4	the	the	DT
cord-290004-v3ruj5bq	14	5	A	A	NNP
cord-290004-v3ruj5bq	14	6	/	/	SYM
cord-290004-v3ruj5bq	14	7	H1N1pdm09	H1N1pdm09	NNP
cord-290004-v3ruj5bq	14	8	virus	virus	NN
cord-290004-v3ruj5bq	14	9	(	(	-LRB-
cord-290004-v3ruj5bq	14	10	"	"	``
cord-290004-v3ruj5bq	14	11	swine	swine	NN
cord-290004-v3ruj5bq	14	12	flu	flu	NN
cord-290004-v3ruj5bq	14	13	"	"	''
cord-290004-v3ruj5bq	14	14	)	)	-RRB-
cord-290004-v3ruj5bq	14	15	was	be	VBD
cord-290004-v3ruj5bq	14	16	the	the	DT
cord-290004-v3ruj5bq	14	17	first	first	JJ
cord-290004-v3ruj5bq	14	18	influenza	influenza	NN
cord-290004-v3ruj5bq	14	19	pandemic	pandemic	NN
cord-290004-v3ruj5bq	14	20	of	of	IN
cord-290004-v3ruj5bq	14	21	the	the	DT
cord-290004-v3ruj5bq	14	22	21st	21st	JJ
cord-290004-v3ruj5bq	14	23	century	century	NN
cord-290004-v3ruj5bq	14	24	.	.	.
cord-290004-v3ruj5bq	15	1	This	this	DT
cord-290004-v3ruj5bq	15	2	H1N1	H1N1	NNP
cord-290004-v3ruj5bq	15	3	virus	virus	NN
cord-290004-v3ruj5bq	15	4	has	have	VBZ
cord-290004-v3ruj5bq	15	5	subsequently	subsequently	RB
cord-290004-v3ruj5bq	15	6	continued	continue	VBN
cord-290004-v3ruj5bq	15	7	to	to	TO
cord-290004-v3ruj5bq	15	8	circulate	circulate	VB
cord-290004-v3ruj5bq	15	9	in	in	IN
cord-290004-v3ruj5bq	15	10	the	the	DT
cord-290004-v3ruj5bq	15	11	human	human	JJ
cord-290004-v3ruj5bq	15	12	population	population	NN
cord-290004-v3ruj5bq	15	13	as	as	IN
cord-290004-v3ruj5bq	15	14	a	a	DT
cord-290004-v3ruj5bq	15	15	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	15	16	virus	virus	NN
cord-290004-v3ruj5bq	15	17	,	,	,
cord-290004-v3ruj5bq	15	18	together	together	RB
cord-290004-v3ruj5bq	15	19	with	with	IN
cord-290004-v3ruj5bq	15	20	influenza	influenza	NN
cord-290004-v3ruj5bq	15	21	A	A	NNP
cord-290004-v3ruj5bq	15	22	/	/	SYM
cord-290004-v3ruj5bq	15	23	H3N2	H3N2	NNP
cord-290004-v3ruj5bq	15	24	and	and	CC
cord-290004-v3ruj5bq	15	25	influenza	influenza	NN
cord-290004-v3ruj5bq	15	26	B	b	NN
cord-290004-v3ruj5bq	16	1	(	(	-LRB-
cord-290004-v3ruj5bq	16	2	Yamagata	Yamagata	NNP
cord-290004-v3ruj5bq	16	3	-	-	HYPH
cord-290004-v3ruj5bq	16	4	like	like	NNP
cord-290004-v3ruj5bq	16	5	and	and	CC
cord-290004-v3ruj5bq	16	6	Victoria	Victoria	NNP
cord-290004-v3ruj5bq	16	7	-	-	HYPH
cord-290004-v3ruj5bq	16	8	like	like	JJ
cord-290004-v3ruj5bq	16	9	)	)	-RRB-
cord-290004-v3ruj5bq	16	10	viruses	virus	NNS
cord-290004-v3ruj5bq	16	11	.	.	.
cord-290004-v3ruj5bq	17	1	The	the	DT
cord-290004-v3ruj5bq	17	2	current	current	JJ
cord-290004-v3ruj5bq	17	3	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	17	4	influenza	influenza	NN
cord-290004-v3ruj5bq	17	5	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	17	6	contain	contain	VBP
cord-290004-v3ruj5bq	17	7	strains	strain	NNS
cord-290004-v3ruj5bq	17	8	from	from	IN
cord-290004-v3ruj5bq	17	9	each	each	DT
cord-290004-v3ruj5bq	17	10	of	of	IN
cord-290004-v3ruj5bq	17	11	these	these	DT
cord-290004-v3ruj5bq	17	12	viruses	virus	NNS
cord-290004-v3ruj5bq	17	13	.	.	.
cord-290004-v3ruj5bq	18	1	The	the	DT
cord-290004-v3ruj5bq	18	2	World	World	NNP
cord-290004-v3ruj5bq	18	3	Health	Health	NNP
cord-290004-v3ruj5bq	18	4	Organization	Organization	NNP
cord-290004-v3ruj5bq	18	5	(	(	-LRB-
cord-290004-v3ruj5bq	18	6	WHO	who	WP
cord-290004-v3ruj5bq	18	7	)	)	-RRB-
cord-290004-v3ruj5bq	18	8	decides	decide	VBZ
cord-290004-v3ruj5bq	18	9	biannually	biannually	RB
cord-290004-v3ruj5bq	18	10	which	which	WDT
cord-290004-v3ruj5bq	18	11	strains	strain	NNS
cord-290004-v3ruj5bq	18	12	should	should	MD
cord-290004-v3ruj5bq	18	13	be	be	VB
cord-290004-v3ruj5bq	18	14	included	include	VBN
cord-290004-v3ruj5bq	18	15	in	in	IN
cord-290004-v3ruj5bq	18	16	the	the	DT
cord-290004-v3ruj5bq	18	17	vaccine	vaccine	NN
cord-290004-v3ruj5bq	18	18	based	base	VBN
cord-290004-v3ruj5bq	18	19	on	on	IN
cord-290004-v3ruj5bq	18	20	which	which	WDT
cord-290004-v3ruj5bq	18	21	viruses	virus	NNS
cord-290004-v3ruj5bq	18	22	are	be	VBP
cord-290004-v3ruj5bq	18	23	most	most	RBS
cord-290004-v3ruj5bq	18	24	likely	likely	JJ
cord-290004-v3ruj5bq	18	25	to	to	TO
cord-290004-v3ruj5bq	18	26	circulate	circulate	VB
cord-290004-v3ruj5bq	18	27	in	in	IN
cord-290004-v3ruj5bq	18	28	the	the	DT
cord-290004-v3ruj5bq	18	29	upcoming	upcoming	JJ
cord-290004-v3ruj5bq	18	30	season	season	NN
cord-290004-v3ruj5bq	18	31	.	.	.
cord-290004-v3ruj5bq	19	1	Annual	annual	JJ
cord-290004-v3ruj5bq	19	2	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	19	3	influenza	influenza	NN
cord-290004-v3ruj5bq	19	4	vaccination	vaccination	NN
cord-290004-v3ruj5bq	19	5	remains	remain	VBZ
cord-290004-v3ruj5bq	19	6	the	the	DT
cord-290004-v3ruj5bq	19	7	most	most	RBS
cord-290004-v3ruj5bq	19	8	cost	cost	NN
cord-290004-v3ruj5bq	19	9	-	-	HYPH
cord-290004-v3ruj5bq	19	10	effective	effective	JJ
cord-290004-v3ruj5bq	19	11	measure	measure	NN
cord-290004-v3ruj5bq	19	12	to	to	TO
cord-290004-v3ruj5bq	19	13	reduce	reduce	VB
cord-290004-v3ruj5bq	19	14	burden	burden	NN
cord-290004-v3ruj5bq	19	15	of	of	IN
cord-290004-v3ruj5bq	19	16	the	the	DT
cord-290004-v3ruj5bq	19	17	disease	disease	NN
cord-290004-v3ruj5bq	19	18	.	.	.
cord-290004-v3ruj5bq	20	1	However	however	RB
cord-290004-v3ruj5bq	20	2	,	,	,
cord-290004-v3ruj5bq	20	3	the	the	DT
cord-290004-v3ruj5bq	20	4	currently	currently	RB
cord-290004-v3ruj5bq	20	5	licensed	license	VBN
cord-290004-v3ruj5bq	20	6	influenza	influenza	NN
cord-290004-v3ruj5bq	20	7	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	20	8	lack	lack	VBP
cord-290004-v3ruj5bq	20	9	two	two	CD
cord-290004-v3ruj5bq	20	10	essential	essential	JJ
cord-290004-v3ruj5bq	20	11	attributes	attribute	NNS
cord-290004-v3ruj5bq	20	12	:	:	:
cord-290004-v3ruj5bq	21	1	Firstly	firstly	RB
cord-290004-v3ruj5bq	21	2	,	,	,
cord-290004-v3ruj5bq	21	3	they	-PRON-	PRP
cord-290004-v3ruj5bq	21	4	do	do	VBP
cord-290004-v3ruj5bq	21	5	not	not	RB
cord-290004-v3ruj5bq	21	6	produce	produce	VB
cord-290004-v3ruj5bq	21	7	durable	durable	JJ
cord-290004-v3ruj5bq	21	8	protective	protective	JJ
cord-290004-v3ruj5bq	21	9	immunity	immunity	NN
cord-290004-v3ruj5bq	21	10	.	.	.
cord-290004-v3ruj5bq	22	1	Secondly	secondly	RB
cord-290004-v3ruj5bq	22	2	,	,	,
cord-290004-v3ruj5bq	22	3	they	-PRON-	PRP
cord-290004-v3ruj5bq	22	4	do	do	VBP
cord-290004-v3ruj5bq	22	5	not	not	RB
cord-290004-v3ruj5bq	22	6	produce	produce	VB
cord-290004-v3ruj5bq	22	7	a	a	DT
cord-290004-v3ruj5bq	22	8	cross	cross	JJ
cord-290004-v3ruj5bq	22	9	-	-	JJ
cord-290004-v3ruj5bq	22	10	reactive	reactive	JJ
cord-290004-v3ruj5bq	22	11	immune	immune	JJ
cord-290004-v3ruj5bq	22	12	response	response	NN
cord-290004-v3ruj5bq	22	13	that	that	WDT
cord-290004-v3ruj5bq	22	14	can	can	MD
cord-290004-v3ruj5bq	22	15	neutralize	neutralize	VB
cord-290004-v3ruj5bq	22	16	diverse	diverse	JJ
cord-290004-v3ruj5bq	22	17	influenza	influenza	NN
cord-290004-v3ruj5bq	22	18	virus	virus	NN
cord-290004-v3ruj5bq	22	19	strains	strain	NNS
cord-290004-v3ruj5bq	22	20	.	.	.
cord-290004-v3ruj5bq	23	1	Cross	cross	NN
cord-290004-v3ruj5bq	23	2	-	-	NN
cord-290004-v3ruj5bq	23	3	reactivity	reactivity	NN
cord-290004-v3ruj5bq	23	4	is	be	VBZ
cord-290004-v3ruj5bq	23	5	necessary	necessary	JJ
cord-290004-v3ruj5bq	23	6	because	because	IN
cord-290004-v3ruj5bq	23	7	of	of	IN
cord-290004-v3ruj5bq	23	8	the	the	DT
cord-290004-v3ruj5bq	23	9	antigenic	antigenic	JJ
cord-290004-v3ruj5bq	23	10	plasticity	plasticity	NN
cord-290004-v3ruj5bq	23	11	of	of	IN
cord-290004-v3ruj5bq	23	12	the	the	DT
cord-290004-v3ruj5bq	23	13	viral	viral	JJ
cord-290004-v3ruj5bq	23	14	membrane	membrane	NN
cord-290004-v3ruj5bq	23	15	protein	protein	NN
cord-290004-v3ruj5bq	23	16	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	23	17	(	(	-LRB-
cord-290004-v3ruj5bq	23	18	HA	HA	NNP
cord-290004-v3ruj5bq	23	19	)	)	-RRB-
cord-290004-v3ruj5bq	23	20	,	,	,
cord-290004-v3ruj5bq	23	21	which	which	WDT
cord-290004-v3ruj5bq	23	22	leads	lead	VBZ
cord-290004-v3ruj5bq	23	23	to	to	TO
cord-290004-v3ruj5bq	23	24	antigenically	antigenically	RB
cord-290004-v3ruj5bq	23	25	drifted	drift	VBN
cord-290004-v3ruj5bq	23	26	viruses	virus	NNS
cord-290004-v3ruj5bq	23	27	and	and	CC
cord-290004-v3ruj5bq	23	28	potential	potential	JJ
cord-290004-v3ruj5bq	23	29	mismatches	mismatch	NNS
cord-290004-v3ruj5bq	23	30	with	with	IN
cord-290004-v3ruj5bq	23	31	the	the	DT
cord-290004-v3ruj5bq	23	32	vaccine	vaccine	NN
cord-290004-v3ruj5bq	23	33	strains	strain	NNS
cord-290004-v3ruj5bq	23	34	[	[	-LRB-
cord-290004-v3ruj5bq	23	35	3	3	CD
cord-290004-v3ruj5bq	23	36	]	]	-RRB-
cord-290004-v3ruj5bq	23	37	.	.	.
cord-290004-v3ruj5bq	24	1	This	this	DT
cord-290004-v3ruj5bq	24	2	shortcoming	shortcoming	NN
cord-290004-v3ruj5bq	24	3	can	can	MD
cord-290004-v3ruj5bq	24	4	be	be	VB
cord-290004-v3ruj5bq	24	5	addressed	address	VBN
cord-290004-v3ruj5bq	24	6	by	by	IN
cord-290004-v3ruj5bq	24	7	developing	develop	VBG
cord-290004-v3ruj5bq	24	8	new	new	JJ
cord-290004-v3ruj5bq	24	9	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	24	10	targeting	target	VBG
cord-290004-v3ruj5bq	24	11	the	the	DT
cord-290004-v3ruj5bq	24	12	more	more	RBR
cord-290004-v3ruj5bq	24	13	antigenically	antigenically	RB
cord-290004-v3ruj5bq	24	14	conserved	conserve	VBN
cord-290004-v3ruj5bq	24	15	regions	region	NNS
cord-290004-v3ruj5bq	24	16	of	of	IN
cord-290004-v3ruj5bq	24	17	the	the	DT
cord-290004-v3ruj5bq	24	18	influenza	influenza	NN
cord-290004-v3ruj5bq	24	19	virus	virus	NN
cord-290004-v3ruj5bq	24	20	[	[	-LRB-
cord-290004-v3ruj5bq	24	21	4	4	CD
cord-290004-v3ruj5bq	24	22	]	]	-RRB-
cord-290004-v3ruj5bq	24	23	.	.	.
cord-290004-v3ruj5bq	25	1	In	in	IN
cord-290004-v3ruj5bq	25	2	order	order	NN
cord-290004-v3ruj5bq	25	3	to	to	TO
cord-290004-v3ruj5bq	25	4	overcome	overcome	VB
cord-290004-v3ruj5bq	25	5	these	these	DT
cord-290004-v3ruj5bq	25	6	barriers	barrier	NNS
cord-290004-v3ruj5bq	25	7	,	,	,
cord-290004-v3ruj5bq	25	8	efforts	effort	NNS
cord-290004-v3ruj5bq	25	9	have	have	VBP
cord-290004-v3ruj5bq	25	10	been	be	VBN
cord-290004-v3ruj5bq	25	11	made	make	VBN
cord-290004-v3ruj5bq	25	12	to	to	TO
cord-290004-v3ruj5bq	25	13	develop	develop	VB
cord-290004-v3ruj5bq	25	14	next	next	JJ
cord-290004-v3ruj5bq	25	15	-	-	HYPH
cord-290004-v3ruj5bq	25	16	generation	generation	NN
cord-290004-v3ruj5bq	25	17	influenza	influenza	NN
cord-290004-v3ruj5bq	25	18	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	25	19	that	that	WDT
cord-290004-v3ruj5bq	25	20	provide	provide	VBP
cord-290004-v3ruj5bq	25	21	robust	robust	JJ
cord-290004-v3ruj5bq	25	22	,	,	,
cord-290004-v3ruj5bq	25	23	long	long	RB
cord-290004-v3ruj5bq	25	24	-	-	HYPH
cord-290004-v3ruj5bq	25	25	lasting	last	VBG
cord-290004-v3ruj5bq	25	26	protection	protection	NN
cord-290004-v3ruj5bq	25	27	against	against	IN
cord-290004-v3ruj5bq	25	28	diverse	diverse	JJ
cord-290004-v3ruj5bq	25	29	influenza	influenza	NN
cord-290004-v3ruj5bq	25	30	A	a	DT
cord-290004-v3ruj5bq	25	31	subtypes	subtype	NNS
cord-290004-v3ruj5bq	25	32	(	(	-LRB-
cord-290004-v3ruj5bq	25	33	Table	table	NN
cord-290004-v3ruj5bq	25	34	1	1	CD
cord-290004-v3ruj5bq	25	35	)	)	-RRB-
cord-290004-v3ruj5bq	25	36	[	[	-LRB-
cord-290004-v3ruj5bq	25	37	5	5	CD
cord-290004-v3ruj5bq	25	38	]	]	-RRB-
cord-290004-v3ruj5bq	25	39	.	.	.
cord-290004-v3ruj5bq	26	1	The	the	DT
cord-290004-v3ruj5bq	26	2	ultimate	ultimate	JJ
cord-290004-v3ruj5bq	26	3	goal	goal	NN
cord-290004-v3ruj5bq	26	4	is	be	VBZ
cord-290004-v3ruj5bq	26	5	to	to	TO
cord-290004-v3ruj5bq	26	6	develop	develop	VB
cord-290004-v3ruj5bq	26	7	a	a	DT
cord-290004-v3ruj5bq	26	8	"	"	``
cord-290004-v3ruj5bq	26	9	universal	universal	JJ
cord-290004-v3ruj5bq	26	10	"	"	''
cord-290004-v3ruj5bq	26	11	influenza	influenza	NN
cord-290004-v3ruj5bq	26	12	vaccine	vaccine	NN
cord-290004-v3ruj5bq	26	13	that	that	WDT
cord-290004-v3ruj5bq	26	14	covers	cover	VBZ
cord-290004-v3ruj5bq	26	15	all	all	DT
cord-290004-v3ruj5bq	26	16	influenza	influenza	NN
cord-290004-v3ruj5bq	26	17	A	a	NN
cord-290004-v3ruj5bq	26	18	and	and	CC
cord-290004-v3ruj5bq	26	19	B	b	NN
cord-290004-v3ruj5bq	26	20	viruses	virus	NNS
cord-290004-v3ruj5bq	26	21	.	.	.
cord-290004-v3ruj5bq	27	1	[	[	-LRB-
cord-290004-v3ruj5bq	27	2	6	6	CD
cord-290004-v3ruj5bq	27	3	]	]	-RRB-
cord-290004-v3ruj5bq	27	4	.	.	.
cord-290004-v3ruj5bq	28	1	Provide	provide	VB
cord-290004-v3ruj5bq	28	2	protection	protection	NN
cord-290004-v3ruj5bq	28	3	against	against	IN
cord-290004-v3ruj5bq	28	4	all	all	DT
cord-290004-v3ruj5bq	28	5	HA	HA	NNP
cord-290004-v3ruj5bq	28	6	subtypes	subtype	NNS
cord-290004-v3ruj5bq	28	7	and	and	CC
cord-290004-v3ruj5bq	28	8	at	at	IN
cord-290004-v3ruj5bq	28	9	a	a	DT
cord-290004-v3ruj5bq	28	10	minimum	minimum	JJ
cord-290004-v3ruj5bq	28	11	protection	protection	NN
cord-290004-v3ruj5bq	28	12	against	against	IN
cord-290004-v3ruj5bq	28	13	H1	H1	NNP
cord-290004-v3ruj5bq	28	14	,	,	,
cord-290004-v3ruj5bq	28	15	H2	H2	NNP
cord-290004-v3ruj5bq	28	16	,	,	,
cord-290004-v3ruj5bq	28	17	H3	H3	NNP
cord-290004-v3ruj5bq	28	18	,	,	,
cord-290004-v3ruj5bq	28	19	H5	H5	NNP
cord-290004-v3ruj5bq	28	20	,	,	,
cord-290004-v3ruj5bq	28	21	H7	H7	NNP
cord-290004-v3ruj5bq	28	22	and	and	CC
cord-290004-v3ruj5bq	28	23	H9	H9	NNP
cord-290004-v3ruj5bq	28	24	subtypes	subtype	NNS
cord-290004-v3ruj5bq	28	25	.	.	.
cord-290004-v3ruj5bq	29	1	Provide	provide	VB
cord-290004-v3ruj5bq	29	2	a	a	DT
cord-290004-v3ruj5bq	29	3	decade	decade	NN
cord-290004-v3ruj5bq	29	4	or	or	CC
cord-290004-v3ruj5bq	29	5	more	more	JJR
cord-290004-v3ruj5bq	29	6	of	of	IN
cord-290004-v3ruj5bq	29	7	protection	protection	NN
cord-290004-v3ruj5bq	29	8	.	.	.
cord-290004-v3ruj5bq	30	1	Use	use	VB
cord-290004-v3ruj5bq	30	2	manufacturing	manufacture	VBG
cord-290004-v3ruj5bq	30	3	technology	technology	NN
cord-290004-v3ruj5bq	30	4	that	that	WDT
cord-290004-v3ruj5bq	30	5	can	can	MD
cord-290004-v3ruj5bq	30	6	be	be	VB
cord-290004-v3ruj5bq	30	7	readily	readily	RB
cord-290004-v3ruj5bq	30	8	transferred	transfer	VBN
cord-290004-v3ruj5bq	30	9	to	to	IN
cord-290004-v3ruj5bq	30	10	developing	develop	VBG
cord-290004-v3ruj5bq	30	11	-	-	HYPH
cord-290004-v3ruj5bq	30	12	world	world	NN
cord-290004-v3ruj5bq	30	13	countries	country	NNS
cord-290004-v3ruj5bq	30	14	.	.	.
cord-290004-v3ruj5bq	31	1	Provide	provide	VB
cord-290004-v3ruj5bq	31	2	immunologic	immunologic	JJ
cord-290004-v3ruj5bq	31	3	protection	protection	NN
cord-290004-v3ruj5bq	31	4	for	for	IN
cord-290004-v3ruj5bq	31	5	those	those	DT
cord-290004-v3ruj5bq	31	6	populations	population	NNS
cord-290004-v3ruj5bq	31	7	most	most	RBS
cord-290004-v3ruj5bq	31	8	at	at	IN
cord-290004-v3ruj5bq	31	9	risk	risk	NN
cord-290004-v3ruj5bq	31	10	for	for	IN
cord-290004-v3ruj5bq	31	11	severe	severe	JJ
cord-290004-v3ruj5bq	31	12	disease	disease	NN
cord-290004-v3ruj5bq	31	13	and	and	CC
cord-290004-v3ruj5bq	31	14	increased	increase	VBN
cord-290004-v3ruj5bq	31	15	mortality	mortality	NN
cord-290004-v3ruj5bq	31	16	Use	use	VB
cord-290004-v3ruj5bq	31	17	inexpensive	inexpensive	JJ
cord-290004-v3ruj5bq	31	18	manufacturing	manufacturing	NN
cord-290004-v3ruj5bq	31	19	technology	technology	NN
cord-290004-v3ruj5bq	31	20	that	that	WDT
cord-290004-v3ruj5bq	31	21	permits	permit	VBZ
cord-290004-v3ruj5bq	31	22	rapid	rapid	JJ
cord-290004-v3ruj5bq	31	23	and	and	CC
cord-290004-v3ruj5bq	31	24	highly	highly	RB
cord-290004-v3ruj5bq	31	25	scalable	scalable	JJ
cord-290004-v3ruj5bq	31	26	production	production	NN
cord-290004-v3ruj5bq	31	27	,	,	,
cord-290004-v3ruj5bq	31	28	particularly	particularly	RB
cord-290004-v3ruj5bq	31	29	to	to	TO
cord-290004-v3ruj5bq	31	30	address	address	VB
cord-290004-v3ruj5bq	31	31	emergence	emergence	NN
cord-290004-v3ruj5bq	31	32	of	of	IN
cord-290004-v3ruj5bq	31	33	a	a	DT
cord-290004-v3ruj5bq	31	34	pandemic	pandemic	NN
cord-290004-v3ruj5bq	31	35	virus	virus	NN
cord-290004-v3ruj5bq	31	36	.	.	.
cord-290004-v3ruj5bq	32	1	Offer	offer	VB
cord-290004-v3ruj5bq	32	2	heat	heat	NN
cord-290004-v3ruj5bq	32	3	stability	stability	NN
cord-290004-v3ruj5bq	32	4	,	,	,
cord-290004-v3ruj5bq	32	5	thereby	thereby	RB
cord-290004-v3ruj5bq	32	6	eliminating	eliminate	VBG
cord-290004-v3ruj5bq	32	7	the	the	DT
cord-290004-v3ruj5bq	32	8	need	need	NN
cord-290004-v3ruj5bq	32	9	to	to	TO
cord-290004-v3ruj5bq	32	10	maintain	maintain	VB
cord-290004-v3ruj5bq	32	11	a	a	DT
cord-290004-v3ruj5bq	32	12	cold	cold	JJ
cord-290004-v3ruj5bq	32	13	chain	chain	NN
cord-290004-v3ruj5bq	32	14	.	.	.
cord-290004-v3ruj5bq	33	1	Rarely	rarely	RB
cord-290004-v3ruj5bq	33	2	cause	cause	VB
cord-290004-v3ruj5bq	33	3	adverse	adverse	JJ
cord-290004-v3ruj5bq	33	4	events	event	NNS
cord-290004-v3ruj5bq	33	5	,	,	,
cord-290004-v3ruj5bq	33	6	and	and	CC
cord-290004-v3ruj5bq	33	7	any	any	DT
cord-290004-v3ruj5bq	33	8	adverse	adverse	JJ
cord-290004-v3ruj5bq	33	9	events	event	NNS
cord-290004-v3ruj5bq	33	10	are	be	VBP
cord-290004-v3ruj5bq	33	11	mild	mild	JJ
cord-290004-v3ruj5bq	33	12	and	and	CC
cord-290004-v3ruj5bq	33	13	temporary	temporary	JJ
cord-290004-v3ruj5bq	33	14	.	.	.
cord-290004-v3ruj5bq	34	1	Do	do	VB
cord-290004-v3ruj5bq	34	2	not	not	RB
cord-290004-v3ruj5bq	34	3	require	require	VB
cord-290004-v3ruj5bq	34	4	injection	injection	NN
cord-290004-v3ruj5bq	34	5	for	for	IN
cord-290004-v3ruj5bq	34	6	administration	administration	NN
cord-290004-v3ruj5bq	34	7	.	.	.
cord-290004-v3ruj5bq	35	1	Do	do	VB
cord-290004-v3ruj5bq	35	2	not	not	RB
cord-290004-v3ruj5bq	35	3	require	require	VB
cord-290004-v3ruj5bq	35	4	injection	injection	NN
cord-290004-v3ruj5bq	35	5	for	for	IN
cord-290004-v3ruj5bq	35	6	administration	administration	NN
cord-290004-v3ruj5bq	35	7	.	.	.
cord-290004-v3ruj5bq	36	1	The	the	DT
cord-290004-v3ruj5bq	36	2	influenza	influenza	NN
cord-290004-v3ruj5bq	36	3	virus	virus	NN
cord-290004-v3ruj5bq	36	4	is	be	VBZ
cord-290004-v3ruj5bq	36	5	an	an	DT
cord-290004-v3ruj5bq	36	6	enveloped	envelop	VBN
cord-290004-v3ruj5bq	36	7	virus	virus	NN
cord-290004-v3ruj5bq	36	8	with	with	IN
cord-290004-v3ruj5bq	36	9	a	a	DT
cord-290004-v3ruj5bq	36	10	segmented	segmented	JJ
cord-290004-v3ruj5bq	36	11	,	,	,
cord-290004-v3ruj5bq	36	12	negative	negative	JJ
cord-290004-v3ruj5bq	36	13	-	-	HYPH
cord-290004-v3ruj5bq	36	14	sense	sense	NN
cord-290004-v3ruj5bq	36	15	,	,	,
cord-290004-v3ruj5bq	36	16	single	single	JJ
cord-290004-v3ruj5bq	36	17	-	-	HYPH
cord-290004-v3ruj5bq	36	18	strand	strand	NN
cord-290004-v3ruj5bq	36	19	RNA	RNA	NNP
cord-290004-v3ruj5bq	36	20	genome	genome	NN
cord-290004-v3ruj5bq	36	21	(	(	-LRB-
cord-290004-v3ruj5bq	36	22	Figure	figure	NN
cord-290004-v3ruj5bq	36	23	1	1	CD
cord-290004-v3ruj5bq	36	24	)	)	-RRB-
cord-290004-v3ruj5bq	36	25	.	.	.
cord-290004-v3ruj5bq	37	1	There	there	EX
cord-290004-v3ruj5bq	37	2	are	be	VBP
cord-290004-v3ruj5bq	37	3	four	four	CD
cord-290004-v3ruj5bq	37	4	types	type	NNS
cord-290004-v3ruj5bq	37	5	of	of	IN
cord-290004-v3ruj5bq	37	6	influenza	influenza	NN
cord-290004-v3ruj5bq	37	7	:	:	:
cord-290004-v3ruj5bq	37	8	A	a	NN
cord-290004-v3ruj5bq	37	9	,	,	,
cord-290004-v3ruj5bq	37	10	B	b	NN
cord-290004-v3ruj5bq	37	11	,	,	,
cord-290004-v3ruj5bq	37	12	C	C	NNP
cord-290004-v3ruj5bq	37	13	,	,	,
cord-290004-v3ruj5bq	37	14	and	and	CC
cord-290004-v3ruj5bq	37	15	D.	D.	NNP
cord-290004-v3ruj5bq	37	16	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	37	17	A	A	NNP
cord-290004-v3ruj5bq	37	18	and	and	CC
cord-290004-v3ruj5bq	37	19	B	B	NNP
cord-290004-v3ruj5bq	37	20	are	be	VBP
cord-290004-v3ruj5bq	37	21	the	the	DT
cord-290004-v3ruj5bq	37	22	only	only	JJ
cord-290004-v3ruj5bq	37	23	types	type	NNS
cord-290004-v3ruj5bq	37	24	that	that	WDT
cord-290004-v3ruj5bq	37	25	cause	cause	VBP
cord-290004-v3ruj5bq	37	26	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	37	27	epidemics	epidemic	NNS
cord-290004-v3ruj5bq	37	28	in	in	IN
cord-290004-v3ruj5bq	37	29	humans	human	NNS
cord-290004-v3ruj5bq	37	30	.	.	.
cord-290004-v3ruj5bq	38	1	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	38	2	A	a	DT
cord-290004-v3ruj5bq	38	3	viruses	virus	NNS
cord-290004-v3ruj5bq	38	4	are	be	VBP
cord-290004-v3ruj5bq	38	5	further	further	RB
cord-290004-v3ruj5bq	38	6	subdivided	subdivide	VBN
cord-290004-v3ruj5bq	38	7	into	into	IN
cord-290004-v3ruj5bq	38	8	subtypes	subtype	NNS
cord-290004-v3ruj5bq	38	9	and	and	CC
cord-290004-v3ruj5bq	38	10	strains	strain	NNS
cord-290004-v3ruj5bq	38	11	depending	depend	VBG
cord-290004-v3ruj5bq	38	12	on	on	IN
cord-290004-v3ruj5bq	38	13	the	the	DT
cord-290004-v3ruj5bq	38	14	characteristics	characteristic	NNS
cord-290004-v3ruj5bq	38	15	of	of	IN
cord-290004-v3ruj5bq	38	16	the	the	DT
cord-290004-v3ruj5bq	38	17	most	most	RBS
cord-290004-v3ruj5bq	38	18	abundant	abundant	JJ
cord-290004-v3ruj5bq	38	19	surface	surface	NN
cord-290004-v3ruj5bq	38	20	proteins	protein	NNS
cord-290004-v3ruj5bq	38	21	,	,	,
cord-290004-v3ruj5bq	38	22	HA	HA	NNP
cord-290004-v3ruj5bq	38	23	and	and	CC
cord-290004-v3ruj5bq	38	24	neuraminidase	neuraminidase	NN
cord-290004-v3ruj5bq	38	25	(	(	-LRB-
cord-290004-v3ruj5bq	38	26	NA	NA	NNP
cord-290004-v3ruj5bq	38	27	)	)	-RRB-
cord-290004-v3ruj5bq	38	28	.	.	.
cord-290004-v3ruj5bq	39	1	HA	HA	NNP
cord-290004-v3ruj5bq	39	2	is	be	VBZ
cord-290004-v3ruj5bq	39	3	a	a	DT
cord-290004-v3ruj5bq	39	4	trimeric	trimeric	JJ
cord-290004-v3ruj5bq	39	5	glycoprotein	glycoprotein	NN
cord-290004-v3ruj5bq	39	6	responsible	responsible	JJ
cord-290004-v3ruj5bq	39	7	for	for	IN
cord-290004-v3ruj5bq	39	8	the	the	DT
cord-290004-v3ruj5bq	39	9	attachment	attachment	NN
cord-290004-v3ruj5bq	39	10	of	of	IN
cord-290004-v3ruj5bq	39	11	the	the	DT
cord-290004-v3ruj5bq	39	12	virus	virus	NN
cord-290004-v3ruj5bq	39	13	to	to	IN
cord-290004-v3ruj5bq	39	14	the	the	DT
cord-290004-v3ruj5bq	39	15	surface	surface	NN
cord-290004-v3ruj5bq	39	16	of	of	IN
cord-290004-v3ruj5bq	39	17	the	the	DT
cord-290004-v3ruj5bq	39	18	host	host	NN
cord-290004-v3ruj5bq	39	19	cell	cell	NN
cord-290004-v3ruj5bq	39	20	by	by	IN
cord-290004-v3ruj5bq	39	21	binding	bind	VBG
cord-290004-v3ruj5bq	39	22	to	to	IN
cord-290004-v3ruj5bq	39	23	sialic	sialic	JJ
cord-290004-v3ruj5bq	39	24	acid	acid	NN
cord-290004-v3ruj5bq	39	25	receptors	receptor	NNS
cord-290004-v3ruj5bq	39	26	.	.	.
cord-290004-v3ruj5bq	40	1	There	there	EX
cord-290004-v3ruj5bq	40	2	are	be	VBP
cord-290004-v3ruj5bq	40	3	18	18	CD
cord-290004-v3ruj5bq	40	4	subtypes	subtype	NNS
cord-290004-v3ruj5bq	40	5	of	of	IN
cord-290004-v3ruj5bq	40	6	HA	HA	NNP
cord-290004-v3ruj5bq	40	7	within	within	IN
cord-290004-v3ruj5bq	40	8	the	the	DT
cord-290004-v3ruj5bq	40	9	influenza	influenza	NN
cord-290004-v3ruj5bq	40	10	A	a	DT
cord-290004-v3ruj5bq	40	11	viruses	virus	NNS
cord-290004-v3ruj5bq	40	12	.	.	.
cord-290004-v3ruj5bq	41	1	These	these	DT
cord-290004-v3ruj5bq	41	2	can	can	MD
cord-290004-v3ruj5bq	41	3	be	be	VB
cord-290004-v3ruj5bq	41	4	divided	divide	VBN
cord-290004-v3ruj5bq	41	5	into	into	IN
cord-290004-v3ruj5bq	41	6	two	two	CD
cord-290004-v3ruj5bq	41	7	distinct	distinct	JJ
cord-290004-v3ruj5bq	41	8	phylogenetic	phylogenetic	JJ
cord-290004-v3ruj5bq	41	9	groups	group	NNS
cord-290004-v3ruj5bq	41	10	:	:	:
cord-290004-v3ruj5bq	41	11	group	group	NN
cord-290004-v3ruj5bq	41	12	1	1	CD
cord-290004-v3ruj5bq	41	13	HA	HA	NNP
cord-290004-v3ruj5bq	41	14	(	(	-LRB-
cord-290004-v3ruj5bq	41	15	H1	h1	NN
cord-290004-v3ruj5bq	41	16	,	,	,
cord-290004-v3ruj5bq	41	17	H2	H2	NNP
cord-290004-v3ruj5bq	41	18	,	,	,
cord-290004-v3ruj5bq	41	19	H5	H5	NNP
cord-290004-v3ruj5bq	41	20	,	,	,
cord-290004-v3ruj5bq	41	21	H6	H6	NNP
cord-290004-v3ruj5bq	41	22	,	,	,
cord-290004-v3ruj5bq	41	23	H8	H8	NNP
cord-290004-v3ruj5bq	41	24	,	,	,
cord-290004-v3ruj5bq	41	25	H9	H9	NNP
cord-290004-v3ruj5bq	41	26	,	,	,
cord-290004-v3ruj5bq	41	27	H11	H11	NNP
cord-290004-v3ruj5bq	41	28	,	,	,
cord-290004-v3ruj5bq	41	29	H12	H12	NNP
cord-290004-v3ruj5bq	41	30	,	,	,
cord-290004-v3ruj5bq	41	31	H13	H13	NNP
cord-290004-v3ruj5bq	41	32	,	,	,
cord-290004-v3ruj5bq	41	33	H16	H16	NNP
cord-290004-v3ruj5bq	41	34	,	,	,
cord-290004-v3ruj5bq	41	35	H17	H17	NNP
cord-290004-v3ruj5bq	41	36	,	,	,
cord-290004-v3ruj5bq	41	37	and	and	CC
cord-290004-v3ruj5bq	41	38	H18	H18	NNP
cord-290004-v3ruj5bq	41	39	)	)	-RRB-
cord-290004-v3ruj5bq	41	40	and	and	CC
cord-290004-v3ruj5bq	41	41	group	group	NN
cord-290004-v3ruj5bq	41	42	2	2	CD
cord-290004-v3ruj5bq	41	43	HA	HA	NNP
cord-290004-v3ruj5bq	41	44	(	(	-LRB-
cord-290004-v3ruj5bq	41	45	H3	H3	NNP
cord-290004-v3ruj5bq	41	46	,	,	,
cord-290004-v3ruj5bq	41	47	H4	H4	NNP
cord-290004-v3ruj5bq	41	48	,	,	,
cord-290004-v3ruj5bq	41	49	H7	H7	NNP
cord-290004-v3ruj5bq	41	50	,	,	,
cord-290004-v3ruj5bq	41	51	H10	H10	NNP
cord-290004-v3ruj5bq	41	52	,	,	,
cord-290004-v3ruj5bq	41	53	H14	H14	NNP
cord-290004-v3ruj5bq	41	54	,	,	,
cord-290004-v3ruj5bq	41	55	and	and	CC
cord-290004-v3ruj5bq	41	56	H15	H15	NNP
cord-290004-v3ruj5bq	41	57	)	)	-RRB-
cord-290004-v3ruj5bq	41	58	.	.	.
cord-290004-v3ruj5bq	42	1	The	the	DT
cord-290004-v3ruj5bq	42	2	HA	HA	NNP
cord-290004-v3ruj5bq	42	3	protein	protein	NN
cord-290004-v3ruj5bq	42	4	comprises	comprise	VBZ
cord-290004-v3ruj5bq	42	5	a	a	DT
cord-290004-v3ruj5bq	42	6	head	head	NN
cord-290004-v3ruj5bq	42	7	domain	domain	NN
cord-290004-v3ruj5bq	42	8	and	and	CC
cord-290004-v3ruj5bq	42	9	a	a	DT
cord-290004-v3ruj5bq	42	10	stalk	stalk	NN
cord-290004-v3ruj5bq	42	11	domain	domain	NN
cord-290004-v3ruj5bq	42	12	,	,	,
cord-290004-v3ruj5bq	42	13	the	the	DT
cord-290004-v3ruj5bq	42	14	latter	latter	JJ
cord-290004-v3ruj5bq	42	15	being	be	VBG
cord-290004-v3ruj5bq	42	16	more	more	RBR
cord-290004-v3ruj5bq	42	17	antigenically	antigenically	RB
cord-290004-v3ruj5bq	42	18	conserved	conserve	VBN
cord-290004-v3ruj5bq	42	19	.	.	.
cord-290004-v3ruj5bq	43	1	Antibodies	antibody	NNS
cord-290004-v3ruj5bq	43	2	targeting	target	VBG
cord-290004-v3ruj5bq	43	3	the	the	DT
cord-290004-v3ruj5bq	43	4	HA	HA	NNP
cord-290004-v3ruj5bq	43	5	head	head	NN
cord-290004-v3ruj5bq	43	6	domain	domain	NN
cord-290004-v3ruj5bq	43	7	are	be	VBP
cord-290004-v3ruj5bq	43	8	usually	usually	RB
cord-290004-v3ruj5bq	43	9	strain	strain	NN
cord-290004-v3ruj5bq	43	10	-	-	HYPH
cord-290004-v3ruj5bq	43	11	specific	specific	JJ
cord-290004-v3ruj5bq	43	12	and	and	CC
cord-290004-v3ruj5bq	43	13	neutralize	neutralize	VB
cord-290004-v3ruj5bq	43	14	influenza	influenza	NN
cord-290004-v3ruj5bq	43	15	viruses	virus	NNS
cord-290004-v3ruj5bq	43	16	by	by	IN
cord-290004-v3ruj5bq	43	17	inhibiting	inhibit	VBG
cord-290004-v3ruj5bq	43	18	the	the	DT
cord-290004-v3ruj5bq	43	19	binding	binding	NN
cord-290004-v3ruj5bq	43	20	of	of	IN
cord-290004-v3ruj5bq	43	21	HA	HA	NNP
cord-290004-v3ruj5bq	43	22	to	to	IN
cord-290004-v3ruj5bq	43	23	sialic	sialic	JJ
cord-290004-v3ruj5bq	43	24	acid	acid	JJ
cord-290004-v3ruj5bq	43	25	receptors	receptor	NNS
cord-290004-v3ruj5bq	43	26	on	on	IN
cord-290004-v3ruj5bq	43	27	the	the	DT
cord-290004-v3ruj5bq	43	28	surface	surface	NN
cord-290004-v3ruj5bq	43	29	of	of	IN
cord-290004-v3ruj5bq	43	30	the	the	DT
cord-290004-v3ruj5bq	43	31	host	host	NN
cord-290004-v3ruj5bq	43	32	cell	cell	NN
cord-290004-v3ruj5bq	43	33	.	.	.
cord-290004-v3ruj5bq	44	1	HA	HA	NNP
cord-290004-v3ruj5bq	44	2	stalk	stalk	VB
cord-290004-v3ruj5bq	44	3	-	-	HYPH
cord-290004-v3ruj5bq	44	4	specific	specific	JJ
cord-290004-v3ruj5bq	44	5	antibodies	antibody	NNS
cord-290004-v3ruj5bq	44	6	can	can	MD
cord-290004-v3ruj5bq	44	7	provide	provide	VB
cord-290004-v3ruj5bq	44	8	heterosubtypic	heterosubtypic	JJ
cord-290004-v3ruj5bq	44	9	protection	protection	NN
cord-290004-v3ruj5bq	44	10	by	by	IN
cord-290004-v3ruj5bq	44	11	blocking	block	VBG
cord-290004-v3ruj5bq	44	12	viral	viral	JJ
cord-290004-v3ruj5bq	44	13	fusion	fusion	NN
cord-290004-v3ruj5bq	44	14	with	with	IN
cord-290004-v3ruj5bq	44	15	the	the	DT
cord-290004-v3ruj5bq	44	16	host	host	NN
cord-290004-v3ruj5bq	44	17	cell	cell	NN
cord-290004-v3ruj5bq	44	18	and	and	CC
cord-290004-v3ruj5bq	44	19	by	by	IN
cord-290004-v3ruj5bq	44	20	eliminating	eliminate	VBG
cord-290004-v3ruj5bq	44	21	infected	infect	VBN
cord-290004-v3ruj5bq	44	22	host	host	NN
cord-290004-v3ruj5bq	44	23	cells	cell	NNS
cord-290004-v3ruj5bq	44	24	through	through	IN
cord-290004-v3ruj5bq	44	25	antibody	antibody	NN
cord-290004-v3ruj5bq	44	26	-	-	HYPH
cord-290004-v3ruj5bq	44	27	dependent	dependent	JJ
cord-290004-v3ruj5bq	44	28	cellular	cellular	JJ
cord-290004-v3ruj5bq	44	29	cytotoxicity	cytotoxicity	NN
cord-290004-v3ruj5bq	44	30	(	(	-LRB-
cord-290004-v3ruj5bq	44	31	ADCC	ADCC	NNP
cord-290004-v3ruj5bq	44	32	)	)	-RRB-
cord-290004-v3ruj5bq	44	33	[	[	-LRB-
cord-290004-v3ruj5bq	44	34	7	7	CD
cord-290004-v3ruj5bq	44	35	,	,	,
cord-290004-v3ruj5bq	44	36	8	8	CD
cord-290004-v3ruj5bq	44	37	]	]	-RRB-
cord-290004-v3ruj5bq	44	38	.	.	.
cord-290004-v3ruj5bq	45	1	The	the	DT
cord-290004-v3ruj5bq	45	2	stalk	stalk	NN
cord-290004-v3ruj5bq	45	3	-	-	HYPH
cord-290004-v3ruj5bq	45	4	specific	specific	JJ
cord-290004-v3ruj5bq	45	5	antibodies	antibody	NNS
cord-290004-v3ruj5bq	45	6	are	be	VBP
cord-290004-v3ruj5bq	45	7	broadly	broadly	RB
cord-290004-v3ruj5bq	45	8	cross	cross	JJ
cord-290004-v3ruj5bq	45	9	-	-	JJ
cord-290004-v3ruj5bq	45	10	reactive	reactive	JJ
cord-290004-v3ruj5bq	45	11	within	within	IN
cord-290004-v3ruj5bq	45	12	an	an	DT
cord-290004-v3ruj5bq	45	13	HA	HA	NNP
cord-290004-v3ruj5bq	45	14	group	group	NN
cord-290004-v3ruj5bq	45	15	[	[	-LRB-
cord-290004-v3ruj5bq	45	16	9	9	CD
cord-290004-v3ruj5bq	45	17	,	,	,
cord-290004-v3ruj5bq	45	18	10	10	CD
cord-290004-v3ruj5bq	45	19	]	]	-RRB-
cord-290004-v3ruj5bq	45	20	.	.	.
cord-290004-v3ruj5bq	46	1	While	while	IN
cord-290004-v3ruj5bq	46	2	HA	HA	NNP
cord-290004-v3ruj5bq	46	3	remains	remain	VBZ
cord-290004-v3ruj5bq	46	4	the	the	DT
cord-290004-v3ruj5bq	46	5	main	main	JJ
cord-290004-v3ruj5bq	46	6	target	target	NN
cord-290004-v3ruj5bq	46	7	of	of	IN
cord-290004-v3ruj5bq	46	8	current	current	JJ
cord-290004-v3ruj5bq	46	9	inactivated	inactivate	VBN
cord-290004-v3ruj5bq	46	10	influenza	influenza	NN
cord-290004-v3ruj5bq	46	11	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	46	12	(	(	-LRB-
cord-290004-v3ruj5bq	46	13	IIVs	IIVs	NNP
cord-290004-v3ruj5bq	46	14	)	)	-RRB-
cord-290004-v3ruj5bq	46	15	,	,	,
cord-290004-v3ruj5bq	46	16	NA	NA	NNP
cord-290004-v3ruj5bq	46	17	has	have	VBZ
cord-290004-v3ruj5bq	46	18	recently	recently	RB
cord-290004-v3ruj5bq	46	19	been	be	VBN
cord-290004-v3ruj5bq	46	20	recognized	recognize	VBN
cord-290004-v3ruj5bq	46	21	as	as	IN
cord-290004-v3ruj5bq	46	22	a	a	DT
cord-290004-v3ruj5bq	46	23	potential	potential	JJ
cord-290004-v3ruj5bq	46	24	target	target	NN
cord-290004-v3ruj5bq	46	25	for	for	IN
cord-290004-v3ruj5bq	46	26	universal	universal	JJ
cord-290004-v3ruj5bq	46	27	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	46	28	[	[	-LRB-
cord-290004-v3ruj5bq	46	29	11	11	CD
cord-290004-v3ruj5bq	46	30	,	,	,
cord-290004-v3ruj5bq	46	31	12	12	CD
cord-290004-v3ruj5bq	46	32	]	]	-RRB-
cord-290004-v3ruj5bq	46	33	.	.	.
cord-290004-v3ruj5bq	47	1	NA	NA	NNP
cord-290004-v3ruj5bq	47	2	functions	function	NNS
cord-290004-v3ruj5bq	47	3	by	by	IN
cord-290004-v3ruj5bq	47	4	catalyzing	catalyze	VBG
cord-290004-v3ruj5bq	47	5	the	the	DT
cord-290004-v3ruj5bq	47	6	cleavage	cleavage	NN
cord-290004-v3ruj5bq	47	7	of	of	IN
cord-290004-v3ruj5bq	47	8	sialic	sialic	JJ
cord-290004-v3ruj5bq	47	9	acids	acid	NNS
cord-290004-v3ruj5bq	47	10	on	on	IN
cord-290004-v3ruj5bq	47	11	the	the	DT
cord-290004-v3ruj5bq	47	12	surface	surface	NN
cord-290004-v3ruj5bq	47	13	of	of	IN
cord-290004-v3ruj5bq	47	14	an	an	DT
cord-290004-v3ruj5bq	47	15	infected	infected	JJ
cord-290004-v3ruj5bq	47	16	cell	cell	NN
cord-290004-v3ruj5bq	47	17	,	,	,
cord-290004-v3ruj5bq	47	18	leading	lead	VBG
cord-290004-v3ruj5bq	47	19	to	to	IN
cord-290004-v3ruj5bq	47	20	the	the	DT
cord-290004-v3ruj5bq	47	21	release	release	NN
cord-290004-v3ruj5bq	47	22	of	of	IN
cord-290004-v3ruj5bq	47	23	newly	newly	RB
cord-290004-v3ruj5bq	47	24	formed	form	VBN
cord-290004-v3ruj5bq	47	25	viruses	virus	NNS
cord-290004-v3ruj5bq	47	26	.	.	.
cord-290004-v3ruj5bq	48	1	Several	several	JJ
cord-290004-v3ruj5bq	48	2	studies	study	NNS
cord-290004-v3ruj5bq	48	3	have	have	VBP
cord-290004-v3ruj5bq	48	4	shown	show	VBN
cord-290004-v3ruj5bq	48	5	that	that	IN
cord-290004-v3ruj5bq	48	6	NA	NA	NNP
cord-290004-v3ruj5bq	48	7	antibody	antibody	NN
cord-290004-v3ruj5bq	48	8	titers	titer	NNS
cord-290004-v3ruj5bq	48	9	correlate	correlate	VBP
cord-290004-v3ruj5bq	48	10	with	with	IN
cord-290004-v3ruj5bq	48	11	protection	protection	NN
cord-290004-v3ruj5bq	48	12	in	in	IN
cord-290004-v3ruj5bq	48	13	humans	human	NNS
cord-290004-v3ruj5bq	48	14	[	[	-LRB-
cord-290004-v3ruj5bq	48	15	13	13	CD
cord-290004-v3ruj5bq	48	16	-	-	SYM
cord-290004-v3ruj5bq	48	17	15	15	CD
cord-290004-v3ruj5bq	48	18	]	]	-RRB-
cord-290004-v3ruj5bq	48	19	.	.	.
cord-290004-v3ruj5bq	49	1	NA	NA	NNP
cord-290004-v3ruj5bq	49	2	-	-	HYPH
cord-290004-v3ruj5bq	49	3	specific	specific	JJ
cord-290004-v3ruj5bq	49	4	antibodies	antibody	NNS
cord-290004-v3ruj5bq	49	5	function	function	VBP
cord-290004-v3ruj5bq	49	6	by	by	IN
cord-290004-v3ruj5bq	49	7	inhibiting	inhibit	VBG
cord-290004-v3ruj5bq	49	8	the	the	DT
cord-290004-v3ruj5bq	49	9	enzymatic	enzymatic	JJ
cord-290004-v3ruj5bq	49	10	activity	activity	NN
cord-290004-v3ruj5bq	49	11	of	of	IN
cord-290004-v3ruj5bq	49	12	NA	NA	NNP
cord-290004-v3ruj5bq	49	13	and	and	CC
cord-290004-v3ruj5bq	49	14	thus	thus	RB
cord-290004-v3ruj5bq	49	15	preventing	prevent	VBG
cord-290004-v3ruj5bq	49	16	the	the	DT
cord-290004-v3ruj5bq	49	17	spread	spread	NN
cord-290004-v3ruj5bq	49	18	of	of	IN
cord-290004-v3ruj5bq	49	19	virions	virion	NNS
cord-290004-v3ruj5bq	49	20	from	from	IN
cord-290004-v3ruj5bq	49	21	infected	infected	JJ
cord-290004-v3ruj5bq	49	22	cells	cell	NNS
cord-290004-v3ruj5bq	49	23	.	.	.
cord-290004-v3ruj5bq	50	1	Fc	Fc	NNP
cord-290004-v3ruj5bq	50	2	receptor	receptor	NN
cord-290004-v3ruj5bq	50	3	-	-	HYPH
cord-290004-v3ruj5bq	50	4	mediated	mediate	VBN
cord-290004-v3ruj5bq	50	5	effector	effector	NN
cord-290004-v3ruj5bq	50	6	functions	function	NNS
cord-290004-v3ruj5bq	50	7	such	such	JJ
cord-290004-v3ruj5bq	50	8	as	as	IN
cord-290004-v3ruj5bq	50	9	ADCC	ADCC	NNP
cord-290004-v3ruj5bq	50	10	have	have	VBP
cord-290004-v3ruj5bq	50	11	also	also	RB
cord-290004-v3ruj5bq	50	12	been	be	VBN
cord-290004-v3ruj5bq	50	13	reported	report	VBN
cord-290004-v3ruj5bq	50	14	for	for	IN
cord-290004-v3ruj5bq	50	15	NA	NA	NNP
cord-290004-v3ruj5bq	50	16	antibodies	antibody	NNS
cord-290004-v3ruj5bq	50	17	[	[	-LRB-
cord-290004-v3ruj5bq	50	18	16	16	CD
cord-290004-v3ruj5bq	50	19	,	,	,
cord-290004-v3ruj5bq	50	20	17	17	CD
cord-290004-v3ruj5bq	50	21	]	]	-RRB-
cord-290004-v3ruj5bq	50	22	.	.	.
cord-290004-v3ruj5bq	51	1	The	the	DT
cord-290004-v3ruj5bq	51	2	matrix	matrix	NN
cord-290004-v3ruj5bq	51	3	protein	protein	NN
cord-290004-v3ruj5bq	51	4	2	2	CD
cord-290004-v3ruj5bq	51	5	ectodomain	ectodomain	NNP
cord-290004-v3ruj5bq	51	6	(	(	-LRB-
cord-290004-v3ruj5bq	51	7	M2e	m2e	NN
cord-290004-v3ruj5bq	51	8	)	)	-RRB-
cord-290004-v3ruj5bq	51	9	protein	protein	NN
cord-290004-v3ruj5bq	51	10	functions	function	NNS
cord-290004-v3ruj5bq	51	11	by	by	IN
cord-290004-v3ruj5bq	51	12	transferring	transfer	VBG
cord-290004-v3ruj5bq	51	13	H	h	NN
cord-290004-v3ruj5bq	51	14	+	+	CC
cord-290004-v3ruj5bq	51	15	ions	ion	NNS
cord-290004-v3ruj5bq	51	16	through	through	IN
cord-290004-v3ruj5bq	51	17	the	the	DT
cord-290004-v3ruj5bq	51	18	viral	viral	JJ
cord-290004-v3ruj5bq	51	19	membrane	membrane	NN
cord-290004-v3ruj5bq	51	20	as	as	IN
cord-290004-v3ruj5bq	51	21	the	the	DT
cord-290004-v3ruj5bq	51	22	virus	virus	NN
cord-290004-v3ruj5bq	51	23	is	be	VBZ
cord-290004-v3ruj5bq	51	24	taken	take	VBN
cord-290004-v3ruj5bq	51	25	up	up	RP
cord-290004-v3ruj5bq	51	26	by	by	IN
cord-290004-v3ruj5bq	51	27	the	the	DT
cord-290004-v3ruj5bq	51	28	endosomes	endosome	NNS
cord-290004-v3ruj5bq	51	29	.	.	.
cord-290004-v3ruj5bq	52	1	This	this	DT
cord-290004-v3ruj5bq	52	2	leads	lead	VBZ
cord-290004-v3ruj5bq	52	3	to	to	TO
cord-290004-v3ruj5bq	52	4	conformational	conformational	VB
cord-290004-v3ruj5bq	52	5	changes	change	NNS
cord-290004-v3ruj5bq	52	6	of	of	IN
cord-290004-v3ruj5bq	52	7	the	the	DT
cord-290004-v3ruj5bq	52	8	HA	HA	NNP
cord-290004-v3ruj5bq	52	9	molecule	molecule	NN
cord-290004-v3ruj5bq	52	10	and	and	CC
cord-290004-v3ruj5bq	52	11	fusion	fusion	NN
cord-290004-v3ruj5bq	52	12	between	between	IN
cord-290004-v3ruj5bq	52	13	the	the	DT
cord-290004-v3ruj5bq	52	14	viral	viral	JJ
cord-290004-v3ruj5bq	52	15	membrane	membrane	NN
cord-290004-v3ruj5bq	52	16	and	and	CC
cord-290004-v3ruj5bq	52	17	the	the	DT
cord-290004-v3ruj5bq	52	18	endosome	endosome	NN
cord-290004-v3ruj5bq	52	19	membrane	membrane	NN
cord-290004-v3ruj5bq	52	20	.	.	.
cord-290004-v3ruj5bq	53	1	As	as	IN
cord-290004-v3ruj5bq	53	2	a	a	DT
cord-290004-v3ruj5bq	53	3	result	result	NN
cord-290004-v3ruj5bq	53	4	,	,	,
cord-290004-v3ruj5bq	53	5	the	the	DT
cord-290004-v3ruj5bq	53	6	viral	viral	JJ
cord-290004-v3ruj5bq	53	7	RNA	RNA	NNP
cord-290004-v3ruj5bq	53	8	is	be	VBZ
cord-290004-v3ruj5bq	53	9	released	release	VBN
cord-290004-v3ruj5bq	53	10	into	into	IN
cord-290004-v3ruj5bq	53	11	the	the	DT
cord-290004-v3ruj5bq	53	12	cytosol	cytosol	NN
cord-290004-v3ruj5bq	53	13	.	.	.
cord-290004-v3ruj5bq	54	1	M2e	M2e	VBG
cord-290004-v3ruj5bq	54	2	-	-	HYPH
cord-290004-v3ruj5bq	54	3	specifc	specifc	JJ
cord-290004-v3ruj5bq	54	4	antibodies	antibody	NNS
cord-290004-v3ruj5bq	54	5	have	have	VBP
cord-290004-v3ruj5bq	54	6	been	be	VBN
cord-290004-v3ruj5bq	54	7	shown	show	VBN
cord-290004-v3ruj5bq	54	8	to	to	TO
cord-290004-v3ruj5bq	54	9	be	be	VB
cord-290004-v3ruj5bq	54	10	protective	protective	JJ
cord-290004-v3ruj5bq	54	11	in	in	IN
cord-290004-v3ruj5bq	54	12	animal	animal	NN
cord-290004-v3ruj5bq	54	13	studies	study	NNS
cord-290004-v3ruj5bq	54	14	,	,	,
cord-290004-v3ruj5bq	54	15	although	although	IN
cord-290004-v3ruj5bq	54	16	the	the	DT
cord-290004-v3ruj5bq	54	17	exact	exact	JJ
cord-290004-v3ruj5bq	54	18	defense	defense	NN
cord-290004-v3ruj5bq	54	19	mechanisms	mechanism	NNS
cord-290004-v3ruj5bq	54	20	are	be	VBP
cord-290004-v3ruj5bq	54	21	not	not	RB
cord-290004-v3ruj5bq	54	22	fully	fully	RB
cord-290004-v3ruj5bq	54	23	understood	understand	VBN
cord-290004-v3ruj5bq	54	24	.	.	.
cord-290004-v3ruj5bq	55	1	T	t	NN
cord-290004-v3ruj5bq	55	2	-	-	HYPH
cord-290004-v3ruj5bq	55	3	cell	cell	NN
cord-290004-v3ruj5bq	55	4	activation	activation	NN
cord-290004-v3ruj5bq	55	5	also	also	RB
cord-290004-v3ruj5bq	55	6	plays	play	VBZ
cord-290004-v3ruj5bq	55	7	an	an	DT
cord-290004-v3ruj5bq	55	8	important	important	JJ
cord-290004-v3ruj5bq	55	9	role	role	NN
cord-290004-v3ruj5bq	55	10	in	in	IN
cord-290004-v3ruj5bq	55	11	targeting	target	VBG
cord-290004-v3ruj5bq	55	12	other	other	JJ
cord-290004-v3ruj5bq	55	13	conserved	conserved	JJ
cord-290004-v3ruj5bq	55	14	proteins	protein	NNS
cord-290004-v3ruj5bq	55	15	that	that	WDT
cord-290004-v3ruj5bq	55	16	are	be	VBP
cord-290004-v3ruj5bq	55	17	generally	generally	RB
cord-290004-v3ruj5bq	55	18	not	not	RB
cord-290004-v3ruj5bq	55	19	exposed	expose	VBN
cord-290004-v3ruj5bq	55	20	on	on	IN
cord-290004-v3ruj5bq	55	21	the	the	DT
cord-290004-v3ruj5bq	55	22	outside	outside	NN
cord-290004-v3ruj5bq	55	23	of	of	IN
cord-290004-v3ruj5bq	55	24	virus	virus	NN
cord-290004-v3ruj5bq	55	25	particles	particle	NNS
cord-290004-v3ruj5bq	55	26	,	,	,
cord-290004-v3ruj5bq	55	27	such	such	JJ
cord-290004-v3ruj5bq	55	28	as	as	IN
cord-290004-v3ruj5bq	55	29	the	the	DT
cord-290004-v3ruj5bq	55	30	nucleoprotein	nucleoprotein	NNP
cord-290004-v3ruj5bq	55	31	(	(	-LRB-
cord-290004-v3ruj5bq	55	32	NP	NP	NNP
cord-290004-v3ruj5bq	55	33	)	)	-RRB-
cord-290004-v3ruj5bq	55	34	and	and	CC
cord-290004-v3ruj5bq	55	35	matrix	matrix	NN
cord-290004-v3ruj5bq	55	36	protein	protein	NN
cord-290004-v3ruj5bq	55	37	1	1	CD
cord-290004-v3ruj5bq	55	38	(	(	-LRB-
cord-290004-v3ruj5bq	55	39	M1	M1	NNP
cord-290004-v3ruj5bq	55	40	)	)	-RRB-
cord-290004-v3ruj5bq	55	41	[	[	-LRB-
cord-290004-v3ruj5bq	55	42	25	25	CD
cord-290004-v3ruj5bq	55	43	]	]	-RRB-
cord-290004-v3ruj5bq	55	44	.	.	.
cord-290004-v3ruj5bq	56	1	These	these	DT
cord-290004-v3ruj5bq	56	2	proteins	protein	NNS
cord-290004-v3ruj5bq	56	3	are	be	VBP
cord-290004-v3ruj5bq	56	4	highly	highly	RB
cord-290004-v3ruj5bq	56	5	conserved	conserve	VBN
cord-290004-v3ruj5bq	56	6	between	between	IN
cord-290004-v3ruj5bq	56	7	influenza	influenza	NN
cord-290004-v3ruj5bq	56	8	A	a	DT
cord-290004-v3ruj5bq	56	9	viruses	virus	NNS
cord-290004-v3ruj5bq	56	10	.	.	.
cord-290004-v3ruj5bq	57	1	Influenza	influenza	NN
cord-290004-v3ruj5bq	57	2	-	-	HYPH
cord-290004-v3ruj5bq	57	3	specific	specific	JJ
cord-290004-v3ruj5bq	57	4	interferon	interferon	NN
cord-290004-v3ruj5bq	57	5	-	-	HYPH
cord-290004-v3ruj5bq	57	6	secreting	secrete	VBG
cord-290004-v3ruj5bq	57	7	T	t	NN
cord-290004-v3ruj5bq	57	8	cells	cell	NNS
cord-290004-v3ruj5bq	57	9	,	,	,
cord-290004-v3ruj5bq	57	10	CD4	CD4	NNP
cord-290004-v3ruj5bq	57	11	+	+	CC
cord-290004-v3ruj5bq	57	12	T	t	NN
cord-290004-v3ruj5bq	57	13	cells	cell	NNS
cord-290004-v3ruj5bq	57	14	,	,	,
cord-290004-v3ruj5bq	57	15	and	and	CC
cord-290004-v3ruj5bq	57	16	CD8	CD8	NNP
cord-290004-v3ruj5bq	57	17	+	+	CC
cord-290004-v3ruj5bq	57	18	T	T	NNP
cord-290004-v3ruj5bq	57	19	cells	cell	NNS
cord-290004-v3ruj5bq	57	20	play	play	VBP
cord-290004-v3ruj5bq	57	21	an	an	DT
cord-290004-v3ruj5bq	57	22	important	important	JJ
cord-290004-v3ruj5bq	57	23	role	role	NN
cord-290004-v3ruj5bq	57	24	in	in	IN
cord-290004-v3ruj5bq	57	25	recovery	recovery	NN
cord-290004-v3ruj5bq	57	26	from	from	IN
cord-290004-v3ruj5bq	57	27	influenza	influenza	NN
cord-290004-v3ruj5bq	57	28	in	in	IN
cord-290004-v3ruj5bq	57	29	humans	human	NNS
cord-290004-v3ruj5bq	57	30	[	[	-LRB-
cord-290004-v3ruj5bq	57	31	26	26	CD
cord-290004-v3ruj5bq	57	32	]	]	-RRB-
cord-290004-v3ruj5bq	58	1	[	[	-LRB-
cord-290004-v3ruj5bq	58	2	27	27	CD
cord-290004-v3ruj5bq	58	3	]	]	-RRB-
cord-290004-v3ruj5bq	58	4	[	[	-LRB-
cord-290004-v3ruj5bq	58	5	28	28	CD
cord-290004-v3ruj5bq	58	6	]	]	-RRB-
cord-290004-v3ruj5bq	58	7	[	[	-LRB-
cord-290004-v3ruj5bq	58	8	29	29	CD
cord-290004-v3ruj5bq	58	9	]	]	-RRB-
cord-290004-v3ruj5bq	58	10	.	.	.
cord-290004-v3ruj5bq	59	1	There	there	EX
cord-290004-v3ruj5bq	59	2	are	be	VBP
cord-290004-v3ruj5bq	59	3	currently	currently	RB
cord-290004-v3ruj5bq	59	4	three	three	CD
cord-290004-v3ruj5bq	59	5	types	type	NNS
cord-290004-v3ruj5bq	59	6	of	of	IN
cord-290004-v3ruj5bq	59	7	licensed	license	VBN
cord-290004-v3ruj5bq	59	8	influenza	influenza	NN
cord-290004-v3ruj5bq	59	9	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	59	10	:	:	:
cord-290004-v3ruj5bq	59	11	inactivated	inactivate	VBN
cord-290004-v3ruj5bq	59	12	,	,	,
cord-290004-v3ruj5bq	59	13	live	live	VBP
cord-290004-v3ruj5bq	59	14	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	59	15	,	,	,
cord-290004-v3ruj5bq	59	16	and	and	CC
cord-290004-v3ruj5bq	59	17	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	59	18	HA	HA	NNP
cord-290004-v3ruj5bq	59	19	(	(	-LRB-
cord-290004-v3ruj5bq	59	20	Figure	figure	NN
cord-290004-v3ruj5bq	59	21	2	2	CD
cord-290004-v3ruj5bq	59	22	)	)	-RRB-
cord-290004-v3ruj5bq	59	23	.	.	.
cord-290004-v3ruj5bq	60	1	Inactivated	inactivate	VBN
cord-290004-v3ruj5bq	60	2	influenza	influenza	NN
cord-290004-v3ruj5bq	60	3	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	60	4	(	(	-LRB-
cord-290004-v3ruj5bq	60	5	IIVs	IIVs	NNP
cord-290004-v3ruj5bq	60	6	)	)	-RRB-
cord-290004-v3ruj5bq	60	7	are	be	VBP
cord-290004-v3ruj5bq	60	8	the	the	DT
cord-290004-v3ruj5bq	60	9	most	most	RBS
cord-290004-v3ruj5bq	60	10	commonly	commonly	RB
cord-290004-v3ruj5bq	60	11	used	use	VBN
cord-290004-v3ruj5bq	60	12	,	,	,
cord-290004-v3ruj5bq	60	13	partly	partly	RB
cord-290004-v3ruj5bq	60	14	because	because	IN
cord-290004-v3ruj5bq	60	15	of	of	IN
cord-290004-v3ruj5bq	60	16	their	-PRON-	PRP$
cord-290004-v3ruj5bq	60	17	well	well	RB
cord-290004-v3ruj5bq	60	18	-	-	HYPH
cord-290004-v3ruj5bq	60	19	documented	document	VBN
cord-290004-v3ruj5bq	60	20	safety	safety	NN
cord-290004-v3ruj5bq	60	21	and	and	CC
cord-290004-v3ruj5bq	60	22	low	low	JJ
cord-290004-v3ruj5bq	60	23	production	production	NN
cord-290004-v3ruj5bq	60	24	costs	cost	NNS
cord-290004-v3ruj5bq	60	25	.	.	.
cord-290004-v3ruj5bq	61	1	The	the	DT
cord-290004-v3ruj5bq	61	2	IIVs	iiv	NNS
cord-290004-v3ruj5bq	61	3	come	come	VBP
cord-290004-v3ruj5bq	61	4	in	in	IN
cord-290004-v3ruj5bq	61	5	three	three	CD
cord-290004-v3ruj5bq	61	6	variants	variant	NNS
cord-290004-v3ruj5bq	61	7	:	:	:
cord-290004-v3ruj5bq	61	8	whole	whole	JJ
cord-290004-v3ruj5bq	61	9	-	-	HYPH
cord-290004-v3ruj5bq	61	10	virion	virion	NN
cord-290004-v3ruj5bq	61	11	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	61	12	,	,	,
cord-290004-v3ruj5bq	61	13	split	split	NN
cord-290004-v3ruj5bq	61	14	-	-	HYPH
cord-290004-v3ruj5bq	61	15	virion	virion	NN
cord-290004-v3ruj5bq	61	16	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	61	17	,	,	,
cord-290004-v3ruj5bq	61	18	and	and	CC
cord-290004-v3ruj5bq	61	19	subunit	subunit	NN
cord-290004-v3ruj5bq	61	20	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	61	21	,	,	,
cord-290004-v3ruj5bq	61	22	which	which	WDT
cord-290004-v3ruj5bq	61	23	contain	contain	VBP
cord-290004-v3ruj5bq	61	24	purified	purify	VBN
cord-290004-v3ruj5bq	61	25	HA	HA	NNP
cord-290004-v3ruj5bq	61	26	and	and	CC
cord-290004-v3ruj5bq	61	27	NA	NA	NNP
cord-290004-v3ruj5bq	61	28	.	.	.
cord-290004-v3ruj5bq	62	1	IIVs	iiv	NNS
cord-290004-v3ruj5bq	62	2	are	be	VBP
cord-290004-v3ruj5bq	62	3	traditionally	traditionally	RB
cord-290004-v3ruj5bq	62	4	produced	produce	VBN
cord-290004-v3ruj5bq	62	5	in	in	IN
cord-290004-v3ruj5bq	62	6	embryonated	embryonate	VBN
cord-290004-v3ruj5bq	62	7	chicken	chicken	NN
cord-290004-v3ruj5bq	62	8	eggs	egg	NNS
cord-290004-v3ruj5bq	62	9	.	.	.
cord-290004-v3ruj5bq	63	1	This	this	DT
cord-290004-v3ruj5bq	63	2	egg	egg	NN
cord-290004-v3ruj5bq	63	3	-	-	HYPH
cord-290004-v3ruj5bq	63	4	based	base	VBN
cord-290004-v3ruj5bq	63	5	approach	approach	NN
cord-290004-v3ruj5bq	63	6	has	have	VBZ
cord-290004-v3ruj5bq	63	7	several	several	JJ
cord-290004-v3ruj5bq	63	8	drawbacks	drawback	NNS
cord-290004-v3ruj5bq	63	9	:	:	:
cord-290004-v3ruj5bq	63	10	Firstly	firstly	RB
cord-290004-v3ruj5bq	63	11	,	,	,
cord-290004-v3ruj5bq	63	12	the	the	DT
cord-290004-v3ruj5bq	63	13	production	production	NN
cord-290004-v3ruj5bq	63	14	time	time	NN
cord-290004-v3ruj5bq	63	15	is	be	VBZ
cord-290004-v3ruj5bq	63	16	relatively	relatively	RB
cord-290004-v3ruj5bq	63	17	long	long	JJ
cord-290004-v3ruj5bq	63	18	.	.	.
cord-290004-v3ruj5bq	64	1	Consequently	consequently	RB
cord-290004-v3ruj5bq	64	2	,	,	,
cord-290004-v3ruj5bq	64	3	the	the	DT
cord-290004-v3ruj5bq	64	4	producers	producer	NNS
cord-290004-v3ruj5bq	64	5	have	have	VBP
cord-290004-v3ruj5bq	64	6	to	to	TO
cord-290004-v3ruj5bq	64	7	start	start	VB
cord-290004-v3ruj5bq	64	8	production	production	NN
cord-290004-v3ruj5bq	64	9	months	month	NNS
cord-290004-v3ruj5bq	64	10	in	in	IN
cord-290004-v3ruj5bq	64	11	advance	advance	NN
cord-290004-v3ruj5bq	64	12	of	of	IN
cord-290004-v3ruj5bq	64	13	the	the	DT
cord-290004-v3ruj5bq	64	14	flu	flu	NN
cord-290004-v3ruj5bq	64	15	season	season	NN
cord-290004-v3ruj5bq	64	16	,	,	,
cord-290004-v3ruj5bq	64	17	which	which	WDT
cord-290004-v3ruj5bq	64	18	can	can	MD
cord-290004-v3ruj5bq	64	19	lead	lead	VB
cord-290004-v3ruj5bq	64	20	to	to	IN
cord-290004-v3ruj5bq	64	21	mismatches	mismatch	NNS
cord-290004-v3ruj5bq	64	22	between	between	IN
cord-290004-v3ruj5bq	64	23	the	the	DT
cord-290004-v3ruj5bq	64	24	vaccine	vaccine	NN
cord-290004-v3ruj5bq	64	25	strain	strain	NN
cord-290004-v3ruj5bq	64	26	and	and	CC
cord-290004-v3ruj5bq	64	27	the	the	DT
cord-290004-v3ruj5bq	64	28	circulating	circulate	VBG
cord-290004-v3ruj5bq	64	29	strain	strain	NN
cord-290004-v3ruj5bq	64	30	[	[	-LRB-
cord-290004-v3ruj5bq	64	31	30	30	CD
cord-290004-v3ruj5bq	64	32	]	]	-RRB-
cord-290004-v3ruj5bq	64	33	.	.	.
cord-290004-v3ruj5bq	65	1	In	in	IN
cord-290004-v3ruj5bq	65	2	addition	addition	NN
cord-290004-v3ruj5bq	65	3	,	,	,
cord-290004-v3ruj5bq	65	4	the	the	DT
cord-290004-v3ruj5bq	65	5	prolonged	prolonged	JJ
cord-290004-v3ruj5bq	65	6	production	production	NN
cord-290004-v3ruj5bq	65	7	time	time	NN
cord-290004-v3ruj5bq	65	8	becomes	become	VBZ
cord-290004-v3ruj5bq	65	9	a	a	DT
cord-290004-v3ruj5bq	65	10	crucial	crucial	JJ
cord-290004-v3ruj5bq	65	11	problem	problem	NN
cord-290004-v3ruj5bq	65	12	during	during	IN
cord-290004-v3ruj5bq	65	13	influenza	influenza	NN
cord-290004-v3ruj5bq	65	14	pandemics	pandemic	NNS
cord-290004-v3ruj5bq	65	15	,	,	,
cord-290004-v3ruj5bq	65	16	where	where	WRB
cord-290004-v3ruj5bq	65	17	rapid	rapid	JJ
cord-290004-v3ruj5bq	65	18	production	production	NN
cord-290004-v3ruj5bq	65	19	and	and	CC
cord-290004-v3ruj5bq	65	20	distribution	distribution	NN
cord-290004-v3ruj5bq	65	21	of	of	IN
cord-290004-v3ruj5bq	65	22	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	65	23	are	be	VBP
cord-290004-v3ruj5bq	65	24	essential	essential	JJ
cord-290004-v3ruj5bq	65	25	.	.	.
cord-290004-v3ruj5bq	66	1	Another	another	DT
cord-290004-v3ruj5bq	66	2	issue	issue	NN
cord-290004-v3ruj5bq	66	3	with	with	IN
cord-290004-v3ruj5bq	66	4	the	the	DT
cord-290004-v3ruj5bq	66	5	egg	egg	NN
cord-290004-v3ruj5bq	66	6	-	-	HYPH
cord-290004-v3ruj5bq	66	7	based	base	VBN
cord-290004-v3ruj5bq	66	8	approach	approach	NN
cord-290004-v3ruj5bq	66	9	is	be	VBZ
cord-290004-v3ruj5bq	66	10	the	the	DT
cord-290004-v3ruj5bq	66	11	occurrence	occurrence	NN
cord-290004-v3ruj5bq	66	12	of	of	IN
cord-290004-v3ruj5bq	66	13	egg	egg	NN
cord-290004-v3ruj5bq	66	14	-	-	HYPH
cord-290004-v3ruj5bq	66	15	adapted	adapt	VBN
cord-290004-v3ruj5bq	66	16	mutations	mutation	NNS
cord-290004-v3ruj5bq	66	17	during	during	IN
cord-290004-v3ruj5bq	66	18	the	the	DT
cord-290004-v3ruj5bq	66	19	production	production	NN
cord-290004-v3ruj5bq	66	20	process	process	NN
cord-290004-v3ruj5bq	66	21	,	,	,
cord-290004-v3ruj5bq	66	22	which	which	WDT
cord-290004-v3ruj5bq	66	23	can	can	MD
cord-290004-v3ruj5bq	66	24	lower	lower	VB
cord-290004-v3ruj5bq	66	25	vaccine	vaccine	NN
cord-290004-v3ruj5bq	66	26	effectiveness	effectiveness	NN
cord-290004-v3ruj5bq	66	27	[	[	-LRB-
cord-290004-v3ruj5bq	66	28	31	31	CD
cord-290004-v3ruj5bq	66	29	,	,	,
cord-290004-v3ruj5bq	66	30	32	32	CD
cord-290004-v3ruj5bq	66	31	]	]	-RRB-
cord-290004-v3ruj5bq	66	32	.	.	.
cord-290004-v3ruj5bq	67	1	Cell	cell	NN
cord-290004-v3ruj5bq	67	2	-	-	HYPH
cord-290004-v3ruj5bq	67	3	based	base	VBN
cord-290004-v3ruj5bq	67	4	IIVs	iiv	NNS
cord-290004-v3ruj5bq	67	5	have	have	VBP
cord-290004-v3ruj5bq	67	6	been	be	VBN
cord-290004-v3ruj5bq	67	7	licensed	license	VBN
cord-290004-v3ruj5bq	67	8	in	in	IN
cord-290004-v3ruj5bq	67	9	Europe	Europe	NNP
cord-290004-v3ruj5bq	67	10	and	and	CC
cord-290004-v3ruj5bq	67	11	the	the	DT
cord-290004-v3ruj5bq	67	12	United	United	NNP
cord-290004-v3ruj5bq	67	13	States	States	NNP
cord-290004-v3ruj5bq	67	14	as	as	IN
cord-290004-v3ruj5bq	67	15	an	an	DT
cord-290004-v3ruj5bq	67	16	alternative	alternative	NN
cord-290004-v3ruj5bq	67	17	to	to	IN
cord-290004-v3ruj5bq	67	18	the	the	DT
cord-290004-v3ruj5bq	67	19	egg	egg	NN
cord-290004-v3ruj5bq	67	20	-	-	HYPH
cord-290004-v3ruj5bq	67	21	based	base	VBN
cord-290004-v3ruj5bq	67	22	approach	approach	NN
cord-290004-v3ruj5bq	67	23	.	.	.
cord-290004-v3ruj5bq	68	1	Another	another	DT
cord-290004-v3ruj5bq	68	2	approach	approach	NN
cord-290004-v3ruj5bq	68	3	for	for	IN
cord-290004-v3ruj5bq	68	4	overcoming	overcome	VBG
cord-290004-v3ruj5bq	68	5	egg	egg	NN
cord-290004-v3ruj5bq	68	6	-	-	HYPH
cord-290004-v3ruj5bq	68	7	based	base	VBN
cord-290004-v3ruj5bq	68	8	vaccine	vaccine	NN
cord-290004-v3ruj5bq	68	9	production	production	NN
cord-290004-v3ruj5bq	68	10	is	be	VBZ
cord-290004-v3ruj5bq	68	11	the	the	DT
cord-290004-v3ruj5bq	68	12	use	use	NN
cord-290004-v3ruj5bq	68	13	of	of	IN
cord-290004-v3ruj5bq	68	14	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	68	15	HA	HA	NNP
cord-290004-v3ruj5bq	68	16	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	68	17	,	,	,
cord-290004-v3ruj5bq	68	18	which	which	WDT
cord-290004-v3ruj5bq	68	19	are	be	VBP
cord-290004-v3ruj5bq	68	20	based	base	VBN
cord-290004-v3ruj5bq	68	21	on	on	IN
cord-290004-v3ruj5bq	68	22	a	a	DT
cord-290004-v3ruj5bq	68	23	protein	protein	NN
cord-290004-v3ruj5bq	68	24	-	-	HYPH
cord-290004-v3ruj5bq	68	25	expression	expression	NN
cord-290004-v3ruj5bq	68	26	system	system	NN
cord-290004-v3ruj5bq	68	27	using	use	VBG
cord-290004-v3ruj5bq	68	28	baculoviruses	baculoviruse	NNS
cord-290004-v3ruj5bq	68	29	and	and	CC
cord-290004-v3ruj5bq	68	30	insect	insect	NN
cord-290004-v3ruj5bq	68	31	cells	cell	NNS
cord-290004-v3ruj5bq	68	32	[	[	-LRB-
cord-290004-v3ruj5bq	68	33	33	33	CD
cord-290004-v3ruj5bq	68	34	]	]	-RRB-
cord-290004-v3ruj5bq	68	35	.	.	.
cord-290004-v3ruj5bq	69	1	These	these	DT
cord-290004-v3ruj5bq	69	2	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	69	3	have	have	VBP
cord-290004-v3ruj5bq	69	4	been	be	VBN
cord-290004-v3ruj5bq	69	5	licensed	license	VBN
cord-290004-v3ruj5bq	69	6	in	in	IN
cord-290004-v3ruj5bq	69	7	the	the	DT
cord-290004-v3ruj5bq	69	8	United	United	NNP
cord-290004-v3ruj5bq	69	9	States	States	NNP
cord-290004-v3ruj5bq	69	10	since	since	IN
cord-290004-v3ruj5bq	69	11	2013	2013	CD
cord-290004-v3ruj5bq	69	12	.	.	.
cord-290004-v3ruj5bq	70	1	However	however	RB
cord-290004-v3ruj5bq	70	2	,	,	,
cord-290004-v3ruj5bq	70	3	as	as	IN
cord-290004-v3ruj5bq	70	4	with	with	IN
cord-290004-v3ruj5bq	70	5	the	the	DT
cord-290004-v3ruj5bq	70	6	IIVs	iiv	NNS
cord-290004-v3ruj5bq	70	7	,	,	,
cord-290004-v3ruj5bq	70	8	the	the	DT
cord-290004-v3ruj5bq	70	9	protection	protection	NN
cord-290004-v3ruj5bq	70	10	appears	appear	VBZ
cord-290004-v3ruj5bq	70	11	to	to	TO
cord-290004-v3ruj5bq	70	12	be	be	VB
cord-290004-v3ruj5bq	70	13	strain	strain	NN
cord-290004-v3ruj5bq	70	14	-	-	HYPH
cord-290004-v3ruj5bq	70	15	specific	specific	JJ
cord-290004-v3ruj5bq	70	16	,	,	,
cord-290004-v3ruj5bq	70	17	with	with	IN
cord-290004-v3ruj5bq	70	18	limited	limited	JJ
cord-290004-v3ruj5bq	70	19	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	70	20	.	.	.
cord-290004-v3ruj5bq	71	1	Some	some	DT
cord-290004-v3ruj5bq	71	2	vaccine	vaccine	NN
cord-290004-v3ruj5bq	71	3	formulations	formulation	NNS
cord-290004-v3ruj5bq	71	4	include	include	VBP
cord-290004-v3ruj5bq	71	5	adjuvants	adjuvant	NNS
cord-290004-v3ruj5bq	71	6	in	in	IN
cord-290004-v3ruj5bq	71	7	order	order	NN
cord-290004-v3ruj5bq	71	8	to	to	TO
cord-290004-v3ruj5bq	71	9	improve	improve	VB
cord-290004-v3ruj5bq	71	10	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	71	11	and	and	CC
cord-290004-v3ruj5bq	71	12	vaccine	vaccine	NN
cord-290004-v3ruj5bq	71	13	effectiveness	effectiveness	NN
cord-290004-v3ruj5bq	71	14	[	[	-LRB-
cord-290004-v3ruj5bq	71	15	34	34	CD
cord-290004-v3ruj5bq	71	16	]	]	-RRB-
cord-290004-v3ruj5bq	71	17	.	.	.
cord-290004-v3ruj5bq	72	1	Adjuvants	adjuvant	NNS
cord-290004-v3ruj5bq	72	2	function	function	VBP
cord-290004-v3ruj5bq	72	3	by	by	IN
cord-290004-v3ruj5bq	72	4	increasing	increase	VBG
cord-290004-v3ruj5bq	72	5	antigen	antigen	NN
cord-290004-v3ruj5bq	72	6	uptake	uptake	NN
cord-290004-v3ruj5bq	72	7	and	and	CC
cord-290004-v3ruj5bq	72	8	presentation	presentation	NN
cord-290004-v3ruj5bq	72	9	in	in	IN
cord-290004-v3ruj5bq	72	10	the	the	DT
cord-290004-v3ruj5bq	72	11	local	local	JJ
cord-290004-v3ruj5bq	72	12	draining	drain	VBG
cord-290004-v3ruj5bq	72	13	lymph	lymph	NN
cord-290004-v3ruj5bq	72	14	nodes	node	NNS
cord-290004-v3ruj5bq	72	15	.	.	.
cord-290004-v3ruj5bq	73	1	During	during	IN
cord-290004-v3ruj5bq	73	2	the	the	DT
cord-290004-v3ruj5bq	73	3	2009	2009	CD
cord-290004-v3ruj5bq	73	4	H1N1	H1N1	NNP
cord-290004-v3ruj5bq	73	5	pandemic	pandemic	NN
cord-290004-v3ruj5bq	73	6	,	,	,
cord-290004-v3ruj5bq	73	7	the	the	DT
cord-290004-v3ruj5bq	73	8	use	use	NN
cord-290004-v3ruj5bq	73	9	of	of	IN
cord-290004-v3ruj5bq	73	10	the	the	DT
cord-290004-v3ruj5bq	73	11	oil	oil	NN
cord-290004-v3ruj5bq	73	12	-	-	HYPH
cord-290004-v3ruj5bq	73	13	in	in	IN
cord-290004-v3ruj5bq	73	14	-	-	HYPH
cord-290004-v3ruj5bq	73	15	water	water	NN
cord-290004-v3ruj5bq	73	16	emulsion	emulsion	NN
cord-290004-v3ruj5bq	73	17	(	(	-LRB-
cord-290004-v3ruj5bq	73	18	AS03	AS03	NNP
cord-290004-v3ruj5bq	73	19	)	)	-RRB-
cord-290004-v3ruj5bq	73	20	led	lead	VBD
cord-290004-v3ruj5bq	73	21	to	to	IN
cord-290004-v3ruj5bq	73	22	higher	high	JJR
cord-290004-v3ruj5bq	73	23	B	B	NNP
cord-290004-v3ruj5bq	73	24	and	and	CC
cord-290004-v3ruj5bq	73	25	CD4	CD4	NNP
cord-290004-v3ruj5bq	73	26	T	T	NNP
cord-290004-v3ruj5bq	73	27	-	-	HYPH
cord-290004-v3ruj5bq	73	28	cell	cell	NN
cord-290004-v3ruj5bq	73	29	responses	response	NNS
cord-290004-v3ruj5bq	73	30	than	than	IN
cord-290004-v3ruj5bq	73	31	vaccination	vaccination	NN
cord-290004-v3ruj5bq	73	32	with	with	IN
cord-290004-v3ruj5bq	73	33	nonadjuvanted	nonadjuvanted	JJ
cord-290004-v3ruj5bq	73	34	pandemic	pandemic	NN
cord-290004-v3ruj5bq	73	35	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	73	36	[	[	-LRB-
cord-290004-v3ruj5bq	73	37	35	35	CD
cord-290004-v3ruj5bq	73	38	,	,	,
cord-290004-v3ruj5bq	73	39	36	36	CD
cord-290004-v3ruj5bq	73	40	]	]	-RRB-
cord-290004-v3ruj5bq	73	41	.	.	.
cord-290004-v3ruj5bq	74	1	In	in	IN
cord-290004-v3ruj5bq	74	2	contrast	contrast	NN
cord-290004-v3ruj5bq	74	3	to	to	IN
cord-290004-v3ruj5bq	74	4	IIVs	iiv	NNS
cord-290004-v3ruj5bq	74	5	and	and	CC
cord-290004-v3ruj5bq	74	6	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	74	7	HA	HA	NNP
cord-290004-v3ruj5bq	74	8	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	74	9	,	,	,
cord-290004-v3ruj5bq	74	10	the	the	DT
cord-290004-v3ruj5bq	74	11	live	live	RB
cord-290004-v3ruj5bq	74	12	-	-	HYPH
cord-290004-v3ruj5bq	74	13	attenuated	attenuate	VBN
cord-290004-v3ruj5bq	74	14	influenza	influenza	NN
cord-290004-v3ruj5bq	74	15	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	74	16	(	(	-LRB-
cord-290004-v3ruj5bq	74	17	LAIV	LAIV	NNP
cord-290004-v3ruj5bq	74	18	)	)	-RRB-
cord-290004-v3ruj5bq	74	19	contain	contain	VBP
cord-290004-v3ruj5bq	74	20	live	live	JJ
cord-290004-v3ruj5bq	74	21	,	,	,
cord-290004-v3ruj5bq	74	22	cold	cold	RB
cord-290004-v3ruj5bq	74	23	-	-	HYPH
cord-290004-v3ruj5bq	74	24	adapted	adapt	VBN
cord-290004-v3ruj5bq	74	25	viruses	virus	NNS
cord-290004-v3ruj5bq	74	26	that	that	WDT
cord-290004-v3ruj5bq	74	27	are	be	VBP
cord-290004-v3ruj5bq	74	28	administered	administer	VBN
cord-290004-v3ruj5bq	74	29	as	as	IN
cord-290004-v3ruj5bq	74	30	a	a	DT
cord-290004-v3ruj5bq	74	31	nasal	nasal	NN
cord-290004-v3ruj5bq	74	32	spray	spray	NN
cord-290004-v3ruj5bq	74	33	,	,	,
cord-290004-v3ruj5bq	74	34	leading	lead	VBG
cord-290004-v3ruj5bq	74	35	to	to	IN
cord-290004-v3ruj5bq	74	36	a	a	DT
cord-290004-v3ruj5bq	74	37	restricted	restrict	VBN
cord-290004-v3ruj5bq	74	38	viral	viral	JJ
cord-290004-v3ruj5bq	74	39	replication	replication	NN
cord-290004-v3ruj5bq	74	40	in	in	IN
cord-290004-v3ruj5bq	74	41	the	the	DT
cord-290004-v3ruj5bq	74	42	upper	upper	JJ
cord-290004-v3ruj5bq	74	43	respiratory	respiratory	JJ
cord-290004-v3ruj5bq	74	44	tract	tract	NN
cord-290004-v3ruj5bq	74	45	of	of	IN
cord-290004-v3ruj5bq	74	46	the	the	DT
cord-290004-v3ruj5bq	74	47	recipient	recipient	NN
cord-290004-v3ruj5bq	74	48	[	[	-LRB-
cord-290004-v3ruj5bq	74	49	37	37	CD
cord-290004-v3ruj5bq	74	50	,	,	,
cord-290004-v3ruj5bq	74	51	38	38	CD
cord-290004-v3ruj5bq	74	52	]	]	-RRB-
cord-290004-v3ruj5bq	74	53	.	.	.
cord-290004-v3ruj5bq	75	1	The	the	DT
cord-290004-v3ruj5bq	75	2	LAIV	LAIV	NNP
cord-290004-v3ruj5bq	75	3	induces	induce	VBZ
cord-290004-v3ruj5bq	75	4	broader	broad	JJR
cord-290004-v3ruj5bq	75	5	immune	immune	JJ
cord-290004-v3ruj5bq	75	6	response	response	NN
cord-290004-v3ruj5bq	75	7	,	,	,
cord-290004-v3ruj5bq	75	8	including	include	VBG
cord-290004-v3ruj5bq	75	9	T	t	NN
cord-290004-v3ruj5bq	75	10	-	-	HYPH
cord-290004-v3ruj5bq	75	11	cell	cell	NN
cord-290004-v3ruj5bq	75	12	and	and	CC
cord-290004-v3ruj5bq	75	13	mucosal	mucosal	JJ
cord-290004-v3ruj5bq	75	14	immunity	immunity	NN
cord-290004-v3ruj5bq	75	15	,	,	,
cord-290004-v3ruj5bq	75	16	by	by	IN
cord-290004-v3ruj5bq	75	17	mimicking	mimic	VBG
cord-290004-v3ruj5bq	75	18	natural	natural	JJ
cord-290004-v3ruj5bq	75	19	infection	infection	NN
cord-290004-v3ruj5bq	75	20	[	[	-LRB-
cord-290004-v3ruj5bq	75	21	39	39	CD
cord-290004-v3ruj5bq	75	22	]	]	-RRB-
cord-290004-v3ruj5bq	75	23	[	[	-LRB-
cord-290004-v3ruj5bq	75	24	40	40	CD
cord-290004-v3ruj5bq	75	25	]	]	-RRB-
cord-290004-v3ruj5bq	75	26	[	[	-LRB-
cord-290004-v3ruj5bq	75	27	41	41	CD
cord-290004-v3ruj5bq	75	28	]	]	-RRB-
cord-290004-v3ruj5bq	75	29	.	.	.
cord-290004-v3ruj5bq	76	1	LAIV	LAIV	NNP
cord-290004-v3ruj5bq	76	2	is	be	VBZ
cord-290004-v3ruj5bq	76	3	currently	currently	RB
cord-290004-v3ruj5bq	76	4	licensed	license	VBN
cord-290004-v3ruj5bq	76	5	in	in	IN
cord-290004-v3ruj5bq	76	6	North	North	NNP
cord-290004-v3ruj5bq	76	7	America	America	NNP
cord-290004-v3ruj5bq	76	8	,	,	,
cord-290004-v3ruj5bq	76	9	Europe	Europe	NNP
cord-290004-v3ruj5bq	76	10	,	,	,
cord-290004-v3ruj5bq	76	11	and	and	CC
cord-290004-v3ruj5bq	76	12	India	India	NNP
cord-290004-v3ruj5bq	76	13	.	.	.
cord-290004-v3ruj5bq	77	1	It	-PRON-	PRP
cord-290004-v3ruj5bq	77	2	is	be	VBZ
cord-290004-v3ruj5bq	77	3	generally	generally	RB
cord-290004-v3ruj5bq	77	4	not	not	RB
cord-290004-v3ruj5bq	77	5	recommended	recommend	VBN
cord-290004-v3ruj5bq	77	6	for	for	IN
cord-290004-v3ruj5bq	77	7	people	people	NNS
cord-290004-v3ruj5bq	77	8	younger	young	JJR
cord-290004-v3ruj5bq	77	9	than	than	IN
cord-290004-v3ruj5bq	77	10	2	2	CD
cord-290004-v3ruj5bq	77	11	years	year	NNS
cord-290004-v3ruj5bq	77	12	of	of	IN
cord-290004-v3ruj5bq	77	13	age	age	NN
cord-290004-v3ruj5bq	77	14	due	due	JJ
cord-290004-v3ruj5bq	77	15	to	to	IN
cord-290004-v3ruj5bq	77	16	increased	increase	VBN
cord-290004-v3ruj5bq	77	17	risk	risk	NN
cord-290004-v3ruj5bq	77	18	of	of	IN
cord-290004-v3ruj5bq	77	19	wheezing	wheeze	VBG
cord-290004-v3ruj5bq	77	20	[	[	-LRB-
cord-290004-v3ruj5bq	77	21	42	42	CD
cord-290004-v3ruj5bq	77	22	]	]	-RRB-
cord-290004-v3ruj5bq	77	23	or	or	CC
cord-290004-v3ruj5bq	77	24	for	for	IN
cord-290004-v3ruj5bq	77	25	immunosuppressed	immunosuppressed	JJ
cord-290004-v3ruj5bq	77	26	individuals	individual	NNS
cord-290004-v3ruj5bq	77	27	who	who	WP
cord-290004-v3ruj5bq	77	28	are	be	VBP
cord-290004-v3ruj5bq	77	29	at	at	IN
cord-290004-v3ruj5bq	77	30	greater	great	JJR
cord-290004-v3ruj5bq	77	31	risk	risk	NN
cord-290004-v3ruj5bq	77	32	of	of	IN
cord-290004-v3ruj5bq	77	33	severe	severe	JJ
cord-290004-v3ruj5bq	77	34	influenza	influenza	NN
cord-290004-v3ruj5bq	77	35	illness	illness	NN
cord-290004-v3ruj5bq	77	36	as	as	IN
cord-290004-v3ruj5bq	77	37	the	the	DT
cord-290004-v3ruj5bq	77	38	vaccine	vaccine	NN
cord-290004-v3ruj5bq	77	39	may	may	MD
cord-290004-v3ruj5bq	77	40	produce	produce	VB
cord-290004-v3ruj5bq	77	41	higher	high	JJR
cord-290004-v3ruj5bq	77	42	virus	virus	NN
cord-290004-v3ruj5bq	77	43	titers	titer	NNS
cord-290004-v3ruj5bq	77	44	in	in	IN
cord-290004-v3ruj5bq	77	45	these	these	DT
cord-290004-v3ruj5bq	77	46	individuals	individual	NNS
cord-290004-v3ruj5bq	77	47	,	,	,
cord-290004-v3ruj5bq	77	48	leading	lead	VBG
cord-290004-v3ruj5bq	77	49	to	to	IN
cord-290004-v3ruj5bq	77	50	severe	severe	JJ
cord-290004-v3ruj5bq	77	51	side	side	NN
cord-290004-v3ruj5bq	77	52	effects	effect	NNS
cord-290004-v3ruj5bq	77	53	.	.	.
cord-290004-v3ruj5bq	78	1	Recent	recent	JJ
cord-290004-v3ruj5bq	78	2	scientific	scientific	JJ
cord-290004-v3ruj5bq	78	3	advances	advance	NNS
cord-290004-v3ruj5bq	78	4	have	have	VBP
cord-290004-v3ruj5bq	78	5	made	make	VBN
cord-290004-v3ruj5bq	78	6	way	way	NN
cord-290004-v3ruj5bq	78	7	for	for	IN
cord-290004-v3ruj5bq	78	8	novel	novel	JJ
cord-290004-v3ruj5bq	78	9	vaccine	vaccine	NN
cord-290004-v3ruj5bq	78	10	approaches	approach	NNS
cord-290004-v3ruj5bq	78	11	,	,	,
cord-290004-v3ruj5bq	78	12	enabling	enable	VBG
cord-290004-v3ruj5bq	78	13	a	a	DT
cord-290004-v3ruj5bq	78	14	more	more	RBR
cord-290004-v3ruj5bq	78	15	targeted	target	VBN
cord-290004-v3ruj5bq	78	16	delivery	delivery	NN
cord-290004-v3ruj5bq	78	17	of	of	IN
cord-290004-v3ruj5bq	78	18	conserved	conserved	JJ
cord-290004-v3ruj5bq	78	19	antigens	antigen	NNS
cord-290004-v3ruj5bq	78	20	that	that	WDT
cord-290004-v3ruj5bq	78	21	can	can	MD
cord-290004-v3ruj5bq	78	22	stimulate	stimulate	VB
cord-290004-v3ruj5bq	78	23	the	the	DT
cord-290004-v3ruj5bq	78	24	innate	innate	JJ
cord-290004-v3ruj5bq	78	25	and	and	CC
cord-290004-v3ruj5bq	78	26	adaptive	adaptive	JJ
cord-290004-v3ruj5bq	78	27	immune	immune	JJ
cord-290004-v3ruj5bq	78	28	systems	system	NNS
cord-290004-v3ruj5bq	78	29	.	.	.
cord-290004-v3ruj5bq	79	1	Here	here	RB
cord-290004-v3ruj5bq	79	2	,	,	,
cord-290004-v3ruj5bq	79	3	we	-PRON-	PRP
cord-290004-v3ruj5bq	79	4	highlight	highlight	VBP
cord-290004-v3ruj5bq	79	5	three	three	CD
cord-290004-v3ruj5bq	79	6	vaccine	vaccine	NN
cord-290004-v3ruj5bq	79	7	platforms	platform	NNS
cord-290004-v3ruj5bq	79	8	that	that	WDT
cord-290004-v3ruj5bq	79	9	are	be	VBP
cord-290004-v3ruj5bq	79	10	being	be	VBG
cord-290004-v3ruj5bq	79	11	used	use	VBN
cord-290004-v3ruj5bq	79	12	in	in	IN
cord-290004-v3ruj5bq	79	13	the	the	DT
cord-290004-v3ruj5bq	79	14	development	development	NN
cord-290004-v3ruj5bq	79	15	of	of	IN
cord-290004-v3ruj5bq	79	16	next	next	JJ
cord-290004-v3ruj5bq	79	17	-	-	HYPH
cord-290004-v3ruj5bq	79	18	generation	generation	NN
cord-290004-v3ruj5bq	79	19	influenza	influenza	NN
cord-290004-v3ruj5bq	79	20	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	79	21	(	(	-LRB-
cord-290004-v3ruj5bq	79	22	Figure	figure	NN
cord-290004-v3ruj5bq	79	23	2	2	CD
cord-290004-v3ruj5bq	79	24	)	)	-RRB-
cord-290004-v3ruj5bq	79	25	.	.	.
cord-290004-v3ruj5bq	80	1	Virus	virus	NN
cord-290004-v3ruj5bq	80	2	-	-	HYPH
cord-290004-v3ruj5bq	80	3	like	like	JJ
cord-290004-v3ruj5bq	80	4	particles	particle	NNS
cord-290004-v3ruj5bq	80	5	(	(	-LRB-
cord-290004-v3ruj5bq	80	6	VLPs	vlp	NNS
cord-290004-v3ruj5bq	80	7	)	)	-RRB-
cord-290004-v3ruj5bq	80	8	have	have	VBP
cord-290004-v3ruj5bq	80	9	similar	similar	JJ
cord-290004-v3ruj5bq	80	10	morphological	morphological	JJ
cord-290004-v3ruj5bq	80	11	and	and	CC
cord-290004-v3ruj5bq	80	12	structural	structural	JJ
cord-290004-v3ruj5bq	80	13	features	feature	NNS
cord-290004-v3ruj5bq	80	14	to	to	IN
cord-290004-v3ruj5bq	80	15	viruses	virus	NNS
cord-290004-v3ruj5bq	80	16	but	but	CC
cord-290004-v3ruj5bq	80	17	lack	lack	VBP
cord-290004-v3ruj5bq	80	18	the	the	DT
cord-290004-v3ruj5bq	80	19	viral	viral	JJ
cord-290004-v3ruj5bq	80	20	genome	genome	NN
cord-290004-v3ruj5bq	80	21	[	[	-LRB-
cord-290004-v3ruj5bq	80	22	43	43	CD
cord-290004-v3ruj5bq	80	23	]	]	-RRB-
cord-290004-v3ruj5bq	80	24	.	.	.
cord-290004-v3ruj5bq	81	1	They	-PRON-	PRP
cord-290004-v3ruj5bq	81	2	are	be	VBP
cord-290004-v3ruj5bq	81	3	a	a	DT
cord-290004-v3ruj5bq	81	4	useful	useful	JJ
cord-290004-v3ruj5bq	81	5	vaccine	vaccine	NN
cord-290004-v3ruj5bq	81	6	component	component	NN
cord-290004-v3ruj5bq	81	7	as	as	IN
cord-290004-v3ruj5bq	81	8	the	the	DT
cord-290004-v3ruj5bq	81	9	immune	immune	JJ
cord-290004-v3ruj5bq	81	10	system	system	NN
cord-290004-v3ruj5bq	81	11	recognizes	recognize	VBZ
cord-290004-v3ruj5bq	81	12	VLPs	vlp	NNS
cord-290004-v3ruj5bq	81	13	similarly	similarly	RB
cord-290004-v3ruj5bq	81	14	to	to	IN
cord-290004-v3ruj5bq	81	15	viruses	virus	NNS
cord-290004-v3ruj5bq	81	16	but	but	CC
cord-290004-v3ruj5bq	81	17	without	without	IN
cord-290004-v3ruj5bq	81	18	the	the	DT
cord-290004-v3ruj5bq	81	19	risk	risk	NN
cord-290004-v3ruj5bq	81	20	of	of	IN
cord-290004-v3ruj5bq	81	21	replication	replication	NN
cord-290004-v3ruj5bq	81	22	and	and	CC
cord-290004-v3ruj5bq	81	23	recombination	recombination	NN
cord-290004-v3ruj5bq	81	24	.	.	.
cord-290004-v3ruj5bq	82	1	A	a	DT
cord-290004-v3ruj5bq	82	2	variety	variety	NN
cord-290004-v3ruj5bq	82	3	of	of	IN
cord-290004-v3ruj5bq	82	4	immunogens	immunogen	NNS
cord-290004-v3ruj5bq	82	5	have	have	VBP
cord-290004-v3ruj5bq	82	6	been	be	VBN
cord-290004-v3ruj5bq	82	7	tested	test	VBN
cord-290004-v3ruj5bq	82	8	on	on	IN
cord-290004-v3ruj5bq	82	9	VLPs	vlp	NNS
cord-290004-v3ruj5bq	82	10	,	,	,
cord-290004-v3ruj5bq	82	11	including	include	VBG
cord-290004-v3ruj5bq	82	12	HA	HA	NNP
cord-290004-v3ruj5bq	82	13	,	,	,
cord-290004-v3ruj5bq	82	14	matrix	matrix	NN
cord-290004-v3ruj5bq	82	15	protein	protein	NN
cord-290004-v3ruj5bq	82	16	2	2	CD
cord-290004-v3ruj5bq	82	17	(	(	-LRB-
cord-290004-v3ruj5bq	82	18	M2	M2	NNP
cord-290004-v3ruj5bq	82	19	)	)	-RRB-
cord-290004-v3ruj5bq	82	20	,	,	,
cord-290004-v3ruj5bq	82	21	and	and	CC
cord-290004-v3ruj5bq	82	22	NA	NA	NNP
cord-290004-v3ruj5bq	82	23	[	[	-LRB-
cord-290004-v3ruj5bq	82	24	44	44	CD
cord-290004-v3ruj5bq	82	25	]	]	-RRB-
cord-290004-v3ruj5bq	82	26	[	[	-LRB-
cord-290004-v3ruj5bq	82	27	45	45	CD
cord-290004-v3ruj5bq	82	28	]	]	-RRB-
cord-290004-v3ruj5bq	82	29	[	[	-LRB-
cord-290004-v3ruj5bq	82	30	46	46	CD
cord-290004-v3ruj5bq	82	31	]	]	-RRB-
cord-290004-v3ruj5bq	82	32	.	.	.
cord-290004-v3ruj5bq	83	1	One	one	CD
cord-290004-v3ruj5bq	83	2	of	of	IN
cord-290004-v3ruj5bq	83	3	the	the	DT
cord-290004-v3ruj5bq	83	4	main	main	JJ
cord-290004-v3ruj5bq	83	5	barriers	barrier	NNS
cord-290004-v3ruj5bq	83	6	to	to	IN
cord-290004-v3ruj5bq	83	7	the	the	DT
cord-290004-v3ruj5bq	83	8	use	use	NN
cord-290004-v3ruj5bq	83	9	of	of	IN
cord-290004-v3ruj5bq	83	10	this	this	DT
cord-290004-v3ruj5bq	83	11	vaccine	vaccine	NN
cord-290004-v3ruj5bq	83	12	construct	construct	NN
cord-290004-v3ruj5bq	83	13	is	be	VBZ
cord-290004-v3ruj5bq	83	14	the	the	DT
cord-290004-v3ruj5bq	83	15	challenge	challenge	NN
cord-290004-v3ruj5bq	83	16	of	of	IN
cord-290004-v3ruj5bq	83	17	generating	generate	VBG
cord-290004-v3ruj5bq	83	18	sufficient	sufficient	JJ
cord-290004-v3ruj5bq	83	19	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	83	20	.	.	.
cord-290004-v3ruj5bq	84	1	However	however	RB
cord-290004-v3ruj5bq	84	2	,	,	,
cord-290004-v3ruj5bq	84	3	the	the	DT
cord-290004-v3ruj5bq	84	4	inclusion	inclusion	NN
cord-290004-v3ruj5bq	84	5	of	of	IN
cord-290004-v3ruj5bq	84	6	adjuvants	adjuvant	NNS
cord-290004-v3ruj5bq	84	7	such	such	JJ
cord-290004-v3ruj5bq	84	8	as	as	IN
cord-290004-v3ruj5bq	84	9	toll	toll	NN
cord-290004-v3ruj5bq	84	10	-	-	HYPH
cord-290004-v3ruj5bq	84	11	like	like	JJ
cord-290004-v3ruj5bq	84	12	receptor	receptor	NN
cord-290004-v3ruj5bq	84	13	ligands	ligand	NNS
cord-290004-v3ruj5bq	84	14	has	have	VBZ
cord-290004-v3ruj5bq	84	15	led	lead	VBN
cord-290004-v3ruj5bq	84	16	to	to	IN
cord-290004-v3ruj5bq	84	17	improved	improved	JJ
cord-290004-v3ruj5bq	84	18	vaccine	vaccine	NN
cord-290004-v3ruj5bq	84	19	effectiveness	effectiveness	NN
cord-290004-v3ruj5bq	84	20	[	[	-LRB-
cord-290004-v3ruj5bq	84	21	47	47	CD
cord-290004-v3ruj5bq	84	22	]	]	-RRB-
cord-290004-v3ruj5bq	84	23	.	.	.
cord-290004-v3ruj5bq	85	1	In	in	IN
cord-290004-v3ruj5bq	85	2	contrast	contrast	NN
cord-290004-v3ruj5bq	85	3	to	to	IN
cord-290004-v3ruj5bq	85	4	VLPs	vlps	NN
cord-290004-v3ruj5bq	85	5	,	,	,
cord-290004-v3ruj5bq	85	6	peptide	peptide	NN
cord-290004-v3ruj5bq	85	7	-	-	HYPH
cord-290004-v3ruj5bq	85	8	based	base	VBN
cord-290004-v3ruj5bq	85	9	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	85	10	focus	focus	VBP
cord-290004-v3ruj5bq	85	11	on	on	IN
cord-290004-v3ruj5bq	85	12	minimal	minimal	JJ
cord-290004-v3ruj5bq	85	13	epitopes	epitope	NNS
cord-290004-v3ruj5bq	85	14	of	of	IN
cord-290004-v3ruj5bq	85	15	the	the	DT
cord-290004-v3ruj5bq	85	16	influenza	influenza	NN
cord-290004-v3ruj5bq	85	17	virus	virus	NN
cord-290004-v3ruj5bq	85	18	,	,	,
cord-290004-v3ruj5bq	85	19	such	such	JJ
cord-290004-v3ruj5bq	85	20	as	as	IN
cord-290004-v3ruj5bq	85	21	T	t	NN
cord-290004-v3ruj5bq	85	22	-	-	HYPH
cord-290004-v3ruj5bq	85	23	cell	cell	NN
cord-290004-v3ruj5bq	85	24	-	-	HYPH
cord-290004-v3ruj5bq	85	25	inducing	induce	VBG
cord-290004-v3ruj5bq	85	26	NP	NP	NNP
cord-290004-v3ruj5bq	85	27	and	and	CC
cord-290004-v3ruj5bq	85	28	M1	M1	NNP
cord-290004-v3ruj5bq	85	29	peptides	peptide	NNS
cord-290004-v3ruj5bq	85	30	[	[	-LRB-
cord-290004-v3ruj5bq	85	31	48	48	CD
cord-290004-v3ruj5bq	85	32	,	,	,
cord-290004-v3ruj5bq	85	33	49	49	CD
cord-290004-v3ruj5bq	85	34	]	]	-RRB-
cord-290004-v3ruj5bq	85	35	.	.	.
cord-290004-v3ruj5bq	86	1	However	however	RB
cord-290004-v3ruj5bq	86	2	,	,	,
cord-290004-v3ruj5bq	86	3	as	as	IN
cord-290004-v3ruj5bq	86	4	with	with	IN
cord-290004-v3ruj5bq	86	5	VLP	VLP	NNP
cord-290004-v3ruj5bq	86	6	-	-	HYPH
cord-290004-v3ruj5bq	86	7	based	base	VBN
cord-290004-v3ruj5bq	86	8	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	86	9	,	,	,
cord-290004-v3ruj5bq	86	10	they	-PRON-	PRP
cord-290004-v3ruj5bq	86	11	often	often	RB
cord-290004-v3ruj5bq	86	12	require	require	VBP
cord-290004-v3ruj5bq	86	13	the	the	DT
cord-290004-v3ruj5bq	86	14	use	use	NN
cord-290004-v3ruj5bq	86	15	of	of	IN
cord-290004-v3ruj5bq	86	16	adjuvants	adjuvant	NNS
cord-290004-v3ruj5bq	86	17	or	or	CC
cord-290004-v3ruj5bq	86	18	particulate	particulate	NN
cord-290004-v3ruj5bq	86	19	carriers	carrier	NNS
cord-290004-v3ruj5bq	86	20	for	for	IN
cord-290004-v3ruj5bq	86	21	delivery	delivery	NN
cord-290004-v3ruj5bq	86	22	in	in	IN
cord-290004-v3ruj5bq	86	23	order	order	NN
cord-290004-v3ruj5bq	86	24	to	to	TO
cord-290004-v3ruj5bq	86	25	be	be	VB
cord-290004-v3ruj5bq	86	26	sufficiently	sufficiently	RB
cord-290004-v3ruj5bq	86	27	immunogenic	immunogenic	JJ
cord-290004-v3ruj5bq	86	28	.	.	.
cord-290004-v3ruj5bq	87	1	Nucleic	nucleic	JJ
cord-290004-v3ruj5bq	87	2	-	-	HYPH
cord-290004-v3ruj5bq	87	3	acid	acid	NN
cord-290004-v3ruj5bq	87	4	-	-	HYPH
cord-290004-v3ruj5bq	87	5	based	base	VBN
cord-290004-v3ruj5bq	87	6	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	87	7	use	use	VBP
cord-290004-v3ruj5bq	87	8	RNA	RNA	NNP
cord-290004-v3ruj5bq	87	9	-	-	,
cord-290004-v3ruj5bq	87	10	or	or	CC
cord-290004-v3ruj5bq	87	11	DNA	dna	NN
cord-290004-v3ruj5bq	87	12	-	-	HYPH
cord-290004-v3ruj5bq	87	13	sequences	sequence	NNS
cord-290004-v3ruj5bq	87	14	for	for	IN
cord-290004-v3ruj5bq	87	15	the	the	DT
cord-290004-v3ruj5bq	87	16	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	87	17	antigens	antigen	NNS
cord-290004-v3ruj5bq	87	18	.	.	.
cord-290004-v3ruj5bq	88	1	This	this	DT
cord-290004-v3ruj5bq	88	2	technology	technology	NN
cord-290004-v3ruj5bq	88	3	is	be	VBZ
cord-290004-v3ruj5bq	88	4	especially	especially	RB
cord-290004-v3ruj5bq	88	5	useful	useful	JJ
cord-290004-v3ruj5bq	88	6	in	in	IN
cord-290004-v3ruj5bq	88	7	disease	disease	NN
cord-290004-v3ruj5bq	88	8	outbreaks	outbreak	NNS
cord-290004-v3ruj5bq	88	9	where	where	WRB
cord-290004-v3ruj5bq	88	10	rapid	rapid	JJ
cord-290004-v3ruj5bq	88	11	vaccine	vaccine	NN
cord-290004-v3ruj5bq	88	12	development	development	NN
cord-290004-v3ruj5bq	88	13	is	be	VBZ
cord-290004-v3ruj5bq	88	14	needed	need	VBN
cord-290004-v3ruj5bq	88	15	.	.	.
cord-290004-v3ruj5bq	89	1	Using	use	VBG
cord-290004-v3ruj5bq	89	2	self	self	NN
cord-290004-v3ruj5bq	89	3	-	-	HYPH
cord-290004-v3ruj5bq	89	4	amplifying	amplify	VBG
cord-290004-v3ruj5bq	89	5	mRNA	mrna	NN
cord-290004-v3ruj5bq	89	6	,	,	,
cord-290004-v3ruj5bq	89	7	researchers	researcher	NNS
cord-290004-v3ruj5bq	89	8	were	be	VBD
cord-290004-v3ruj5bq	89	9	able	able	JJ
cord-290004-v3ruj5bq	89	10	to	to	TO
cord-290004-v3ruj5bq	89	11	develop	develop	VB
cord-290004-v3ruj5bq	89	12	a	a	DT
cord-290004-v3ruj5bq	89	13	vaccine	vaccine	NN
cord-290004-v3ruj5bq	89	14	candidate	candidate	NN
cord-290004-v3ruj5bq	89	15	for	for	IN
cord-290004-v3ruj5bq	89	16	the	the	DT
cord-290004-v3ruj5bq	89	17	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	89	18	A	a	DT
cord-290004-v3ruj5bq	89	19	H7N9	H7N9	NNP
cord-290004-v3ruj5bq	89	20	outbreak	outbreak	NN
cord-290004-v3ruj5bq	89	21	in	in	IN
cord-290004-v3ruj5bq	89	22	China	China	NNP
cord-290004-v3ruj5bq	89	23	just	just	RB
cord-290004-v3ruj5bq	89	24	8	8	CD
cord-290004-v3ruj5bq	89	25	days	day	NNS
cord-290004-v3ruj5bq	89	26	after	after	IN
cord-290004-v3ruj5bq	89	27	A	a	NN
cord-290004-v3ruj5bq	89	28	/	/	SYM
cord-290004-v3ruj5bq	89	29	Shanghai/2/2013	shanghai/2/2013	NN
cord-290004-v3ruj5bq	89	30	(	(	-LRB-
cord-290004-v3ruj5bq	89	31	H7N9	H7N9	NNP
cord-290004-v3ruj5bq	89	32	)	)	-RRB-
cord-290004-v3ruj5bq	89	33	sequences	sequence	NNS
cord-290004-v3ruj5bq	89	34	were	be	VBD
cord-290004-v3ruj5bq	89	35	released	release	VBN
cord-290004-v3ruj5bq	89	36	[	[	-LRB-
cord-290004-v3ruj5bq	89	37	50	50	CD
cord-290004-v3ruj5bq	89	38	]	]	-RRB-
cord-290004-v3ruj5bq	89	39	.	.	.
cord-290004-v3ruj5bq	90	1	This	this	DT
cord-290004-v3ruj5bq	90	2	vaccine	vaccine	NN
cord-290004-v3ruj5bq	90	3	platform	platform	NN
cord-290004-v3ruj5bq	90	4	could	could	MD
cord-290004-v3ruj5bq	90	5	be	be	VB
cord-290004-v3ruj5bq	90	6	a	a	DT
cord-290004-v3ruj5bq	90	7	viable	viable	JJ
cord-290004-v3ruj5bq	90	8	option	option	NN
cord-290004-v3ruj5bq	90	9	in	in	IN
cord-290004-v3ruj5bq	90	10	the	the	DT
cord-290004-v3ruj5bq	90	11	ongoing	ongoing	JJ
cord-290004-v3ruj5bq	90	12	efforts	effort	NNS
cord-290004-v3ruj5bq	90	13	to	to	TO
cord-290004-v3ruj5bq	90	14	develop	develop	VB
cord-290004-v3ruj5bq	90	15	a	a	DT
cord-290004-v3ruj5bq	90	16	SARS	SARS	NNP
cord-290004-v3ruj5bq	90	17	-	-	HYPH
cord-290004-v3ruj5bq	90	18	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	90	19	vaccine	vaccine	NN
cord-290004-v3ruj5bq	90	20	.	.	.
cord-290004-v3ruj5bq	91	1	A	a	DT
cord-290004-v3ruj5bq	91	2	phase	phase	NN
cord-290004-v3ruj5bq	91	3	1	1	CD
cord-290004-v3ruj5bq	91	4	clinical	clinical	JJ
cord-290004-v3ruj5bq	91	5	trial	trial	NN
cord-290004-v3ruj5bq	91	6	of	of	IN
cord-290004-v3ruj5bq	91	7	a	a	DT
cord-290004-v3ruj5bq	91	8	DNA	dna	NN
cord-290004-v3ruj5bq	91	9	vaccine	vaccine	NN
cord-290004-v3ruj5bq	91	10	targeting	target	VBG
cord-290004-v3ruj5bq	91	11	the	the	DT
cord-290004-v3ruj5bq	91	12	spike	spike	NN
cord-290004-v3ruj5bq	91	13	protein	protein	NN
cord-290004-v3ruj5bq	91	14	of	of	IN
cord-290004-v3ruj5bq	91	15	SARS	SARS	NNP
cord-290004-v3ruj5bq	91	16	-	-	HYPH
cord-290004-v3ruj5bq	91	17	CoV-1	CoV-1	NNP
cord-290004-v3ruj5bq	91	18	found	find	VBD
cord-290004-v3ruj5bq	91	19	that	that	IN
cord-290004-v3ruj5bq	91	20	the	the	DT
cord-290004-v3ruj5bq	91	21	vaccine	vaccine	NN
cord-290004-v3ruj5bq	91	22	was	be	VBD
cord-290004-v3ruj5bq	91	23	safe	safe	JJ
cord-290004-v3ruj5bq	91	24	and	and	CC
cord-290004-v3ruj5bq	91	25	capable	capable	JJ
cord-290004-v3ruj5bq	91	26	of	of	IN
cord-290004-v3ruj5bq	91	27	eliciting	elicit	VBG
cord-290004-v3ruj5bq	91	28	neutralizing	neutralize	VBG
cord-290004-v3ruj5bq	91	29	antibodies	antibody	NNS
cord-290004-v3ruj5bq	91	30	and	and	CC
cord-290004-v3ruj5bq	91	31	cellular	cellular	JJ
cord-290004-v3ruj5bq	91	32	immune	immune	JJ
cord-290004-v3ruj5bq	91	33	responses	response	NNS
cord-290004-v3ruj5bq	91	34	[	[	-LRB-
cord-290004-v3ruj5bq	91	35	51	51	CD
cord-290004-v3ruj5bq	91	36	]	]	-RRB-
cord-290004-v3ruj5bq	91	37	.	.	.
cord-290004-v3ruj5bq	92	1	Viral	viral	JJ
cord-290004-v3ruj5bq	92	2	vector	vector	NN
cord-290004-v3ruj5bq	92	3	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	92	4	use	use	VBP
cord-290004-v3ruj5bq	92	5	carrier	carrier	NN
cord-290004-v3ruj5bq	92	6	viruses	virus	NNS
cord-290004-v3ruj5bq	92	7	such	such	JJ
cord-290004-v3ruj5bq	92	8	as	as	IN
cord-290004-v3ruj5bq	92	9	modified	modify	VBN
cord-290004-v3ruj5bq	92	10	vaccinia	vaccinia	NN
cord-290004-v3ruj5bq	92	11	virus	virus	NN
cord-290004-v3ruj5bq	92	12	Ankara	Ankara	NNP
cord-290004-v3ruj5bq	92	13	(	(	-LRB-
cord-290004-v3ruj5bq	92	14	MVA	MVA	NNP
cord-290004-v3ruj5bq	92	15	)	)	-RRB-
cord-290004-v3ruj5bq	92	16	or	or	CC
cord-290004-v3ruj5bq	92	17	adenovirus	adenovirus	NN
cord-290004-v3ruj5bq	92	18	containing	contain	VBG
cord-290004-v3ruj5bq	92	19	genes	gene	NNS
cord-290004-v3ruj5bq	92	20	expressing	express	VBG
cord-290004-v3ruj5bq	92	21	influenza	influenza	NN
cord-290004-v3ruj5bq	92	22	-	-	HYPH
cord-290004-v3ruj5bq	92	23	proteins	protein	NNS
cord-290004-v3ruj5bq	92	24	of	of	IN
cord-290004-v3ruj5bq	92	25	interest	interest	NN
cord-290004-v3ruj5bq	92	26	[	[	-LRB-
cord-290004-v3ruj5bq	92	27	52	52	CD
cord-290004-v3ruj5bq	92	28	]	]	-RRB-
cord-290004-v3ruj5bq	92	29	.	.	.
cord-290004-v3ruj5bq	93	1	These	these	DT
cord-290004-v3ruj5bq	93	2	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	93	3	allow	allow	VBP
cord-290004-v3ruj5bq	93	4	for	for	IN
cord-290004-v3ruj5bq	93	5	any	any	DT
cord-290004-v3ruj5bq	93	6	influenza	influenza	NN
cord-290004-v3ruj5bq	93	7	antigens	antigen	NNS
cord-290004-v3ruj5bq	93	8	to	to	TO
cord-290004-v3ruj5bq	93	9	be	be	VB
cord-290004-v3ruj5bq	93	10	expressed	express	VBN
cord-290004-v3ruj5bq	93	11	in	in	IN
cord-290004-v3ruj5bq	93	12	their	-PRON-	PRP$
cord-290004-v3ruj5bq	93	13	native	native	JJ
cord-290004-v3ruj5bq	93	14	conformation	conformation	NN
cord-290004-v3ruj5bq	93	15	or	or	CC
cord-290004-v3ruj5bq	93	16	with	with	IN
cord-290004-v3ruj5bq	93	17	modifications	modification	NNS
cord-290004-v3ruj5bq	93	18	,	,	,
cord-290004-v3ruj5bq	93	19	inducing	induce	VBG
cord-290004-v3ruj5bq	93	20	both	both	CC
cord-290004-v3ruj5bq	93	21	humoral	humoral	JJ
cord-290004-v3ruj5bq	93	22	and	and	CC
cord-290004-v3ruj5bq	93	23	cellular	cellular	JJ
cord-290004-v3ruj5bq	93	24	immune	immune	JJ
cord-290004-v3ruj5bq	93	25	responses	response	NNS
cord-290004-v3ruj5bq	93	26	[	[	-LRB-
cord-290004-v3ruj5bq	93	27	53	53	CD
cord-290004-v3ruj5bq	93	28	]	]	-RRB-
cord-290004-v3ruj5bq	93	29	[	[	-LRB-
cord-290004-v3ruj5bq	93	30	54	54	CD
cord-290004-v3ruj5bq	93	31	]	]	-RRB-
cord-290004-v3ruj5bq	93	32	[	[	-LRB-
cord-290004-v3ruj5bq	93	33	55	55	CD
cord-290004-v3ruj5bq	93	34	]	]	-RRB-
cord-290004-v3ruj5bq	93	35	.	.	.
cord-290004-v3ruj5bq	94	1	Most	Most	JJS
cord-290004-v3ruj5bq	94	2	viral	viral	JJ
cord-290004-v3ruj5bq	94	3	vectors	vector	NNS
cord-290004-v3ruj5bq	94	4	are	be	VBP
cord-290004-v3ruj5bq	94	5	replication	replication	NN
cord-290004-v3ruj5bq	94	6	-	-	HYPH
cord-290004-v3ruj5bq	94	7	deficient	deficient	JJ
cord-290004-v3ruj5bq	94	8	in	in	IN
cord-290004-v3ruj5bq	94	9	mammalian	mammalian	JJ
cord-290004-v3ruj5bq	94	10	host	host	NN
cord-290004-v3ruj5bq	94	11	cells	cell	NNS
cord-290004-v3ruj5bq	94	12	and	and	CC
cord-290004-v3ruj5bq	94	13	are	be	VBP
cord-290004-v3ruj5bq	94	14	therefore	therefore	RB
cord-290004-v3ruj5bq	94	15	safe	safe	JJ
cord-290004-v3ruj5bq	94	16	to	to	IN
cord-290004-v3ruj5bq	94	17	use	use	VB
cord-290004-v3ruj5bq	94	18	.	.	.
cord-290004-v3ruj5bq	95	1	Issues	issue	NNS
cord-290004-v3ruj5bq	95	2	with	with	IN
cord-290004-v3ruj5bq	95	3	pre	pre	JJ
cord-290004-v3ruj5bq	95	4	-	-	JJ
cord-290004-v3ruj5bq	95	5	existing	existing	JJ
cord-290004-v3ruj5bq	95	6	immunity	immunity	NN
cord-290004-v3ruj5bq	95	7	to	to	IN
cord-290004-v3ruj5bq	95	8	some	some	DT
cord-290004-v3ruj5bq	95	9	viral	viral	JJ
cord-290004-v3ruj5bq	95	10	vectors	vector	NNS
cord-290004-v3ruj5bq	95	11	have	have	VBP
cord-290004-v3ruj5bq	95	12	been	be	VBN
cord-290004-v3ruj5bq	95	13	reported	report	VBN
cord-290004-v3ruj5bq	95	14	[	[	-LRB-
cord-290004-v3ruj5bq	95	15	56	56	CD
cord-290004-v3ruj5bq	95	16	]	]	-RRB-
cord-290004-v3ruj5bq	95	17	,	,	,
cord-290004-v3ruj5bq	95	18	although	although	IN
cord-290004-v3ruj5bq	95	19	other	other	JJ
cord-290004-v3ruj5bq	95	20	vectors	vector	NNS
cord-290004-v3ruj5bq	95	21	,	,	,
cord-290004-v3ruj5bq	95	22	such	such	JJ
cord-290004-v3ruj5bq	95	23	as	as	IN
cord-290004-v3ruj5bq	95	24	MVA	MVA	NNP
cord-290004-v3ruj5bq	95	25	,	,	,
cord-290004-v3ruj5bq	95	26	remain	remain	VBP
cord-290004-v3ruj5bq	95	27	immunogenic	immunogenic	JJ
cord-290004-v3ruj5bq	95	28	despite	despite	IN
cord-290004-v3ruj5bq	95	29	the	the	DT
cord-290004-v3ruj5bq	95	30	presence	presence	NN
cord-290004-v3ruj5bq	95	31	of	of	IN
cord-290004-v3ruj5bq	95	32	pre	pre	JJ
cord-290004-v3ruj5bq	95	33	-	-	JJ
cord-290004-v3ruj5bq	95	34	existing	existing	JJ
cord-290004-v3ruj5bq	95	35	immunity	immunity	NN
cord-290004-v3ruj5bq	95	36	.	.	.
cord-290004-v3ruj5bq	96	1	Influenza	influenza	NN
cord-290004-v3ruj5bq	96	2	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	96	3	can	can	MD
cord-290004-v3ruj5bq	96	4	be	be	VB
cord-290004-v3ruj5bq	96	5	divided	divide	VBN
cord-290004-v3ruj5bq	96	6	into	into	IN
cord-290004-v3ruj5bq	96	7	two	two	CD
cord-290004-v3ruj5bq	96	8	categories	category	NNS
cord-290004-v3ruj5bq	96	9	based	base	VBN
cord-290004-v3ruj5bq	96	10	on	on	IN
cord-290004-v3ruj5bq	96	11	their	-PRON-	PRP$
cord-290004-v3ruj5bq	96	12	immunological	immunological	JJ
cord-290004-v3ruj5bq	96	13	features	feature	NNS
cord-290004-v3ruj5bq	96	14	:	:	:
cord-290004-v3ruj5bq	96	15	(	(	-LRB-
cord-290004-v3ruj5bq	96	16	1	1	LS
cord-290004-v3ruj5bq	96	17	)	)	-RRB-
cord-290004-v3ruj5bq	96	18	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	96	19	providing	provide	VBG
cord-290004-v3ruj5bq	96	20	sterile	sterile	JJ
cord-290004-v3ruj5bq	96	21	immunity	immunity	NN
cord-290004-v3ruj5bq	96	22	by	by	IN
cord-290004-v3ruj5bq	96	23	eliciting	elicit	VBG
cord-290004-v3ruj5bq	96	24	HA	HA	NNP
cord-290004-v3ruj5bq	96	25	head	head	NN
cord-290004-v3ruj5bq	96	26	antibodies	antibody	NNS
cord-290004-v3ruj5bq	96	27	that	that	WDT
cord-290004-v3ruj5bq	96	28	prevent	prevent	VBP
cord-290004-v3ruj5bq	96	29	viral	viral	JJ
cord-290004-v3ruj5bq	96	30	attachment	attachment	NN
cord-290004-v3ruj5bq	96	31	to	to	IN
cord-290004-v3ruj5bq	96	32	sialic	sialic	JJ
cord-290004-v3ruj5bq	96	33	acid	acid	NN
cord-290004-v3ruj5bq	96	34	receptors	receptor	NNS
cord-290004-v3ruj5bq	96	35	and	and	CC
cord-290004-v3ruj5bq	96	36	(	(	-LRB-
cord-290004-v3ruj5bq	96	37	2	2	LS
cord-290004-v3ruj5bq	96	38	)	)	-RRB-
cord-290004-v3ruj5bq	96	39	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	96	40	that	that	WDT
cord-290004-v3ruj5bq	96	41	provide	provide	VBP
cord-290004-v3ruj5bq	96	42	infection	infection	NN
cord-290004-v3ruj5bq	96	43	-	-	HYPH
cord-290004-v3ruj5bq	96	44	permissive	permissive	JJ
cord-290004-v3ruj5bq	96	45	immunity	immunity	NN
cord-290004-v3ruj5bq	96	46	by	by	IN
cord-290004-v3ruj5bq	96	47	inducing	induce	VBG
cord-290004-v3ruj5bq	96	48	cellular	cellular	JJ
cord-290004-v3ruj5bq	96	49	immunity	immunity	NN
cord-290004-v3ruj5bq	96	50	or	or	CC
cord-290004-v3ruj5bq	96	51	broadly	broadly	RB
cord-290004-v3ruj5bq	96	52	reactive	reactive	JJ
cord-290004-v3ruj5bq	96	53	antibodies	antibody	NNS
cord-290004-v3ruj5bq	96	54	that	that	WDT
cord-290004-v3ruj5bq	96	55	function	function	VBP
cord-290004-v3ruj5bq	96	56	in	in	IN
cord-290004-v3ruj5bq	96	57	the	the	DT
cord-290004-v3ruj5bq	96	58	later	later	JJ
cord-290004-v3ruj5bq	96	59	stages	stage	NNS
cord-290004-v3ruj5bq	96	60	of	of	IN
cord-290004-v3ruj5bq	96	61	the	the	DT
cord-290004-v3ruj5bq	96	62	viral	viral	JJ
cord-290004-v3ruj5bq	96	63	life	life	NN
cord-290004-v3ruj5bq	96	64	cycle	cycle	NN
cord-290004-v3ruj5bq	96	65	(	(	-LRB-
cord-290004-v3ruj5bq	96	66	Figure	figure	NN
cord-290004-v3ruj5bq	96	67	3	3	CD
cord-290004-v3ruj5bq	96	68	)	)	-RRB-
cord-290004-v3ruj5bq	96	69	.	.	.
cord-290004-v3ruj5bq	97	1	Many	many	JJ
cord-290004-v3ruj5bq	97	2	of	of	IN
cord-290004-v3ruj5bq	97	3	the	the	DT
cord-290004-v3ruj5bq	97	4	infection	infection	NN
cord-290004-v3ruj5bq	97	5	-	-	HYPH
cord-290004-v3ruj5bq	97	6	permissive	permissive	JJ
cord-290004-v3ruj5bq	97	7	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	97	8	that	that	WDT
cord-290004-v3ruj5bq	97	9	are	be	VBP
cord-290004-v3ruj5bq	97	10	in	in	IN
cord-290004-v3ruj5bq	97	11	development	development	NN
cord-290004-v3ruj5bq	97	12	will	will	MD
cord-290004-v3ruj5bq	97	13	probably	probably	RB
cord-290004-v3ruj5bq	97	14	not	not	RB
cord-290004-v3ruj5bq	97	15	be	be	VB
cord-290004-v3ruj5bq	97	16	universal	universal	JJ
cord-290004-v3ruj5bq	97	17	vaccine	vaccine	NN
cord-290004-v3ruj5bq	97	18	candidates	candidate	NNS
cord-290004-v3ruj5bq	97	19	as	as	IN
cord-290004-v3ruj5bq	97	20	stand	stand	VB
cord-290004-v3ruj5bq	97	21	-	-	HYPH
cord-290004-v3ruj5bq	97	22	alone	alone	RB
cord-290004-v3ruj5bq	97	23	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	97	24	but	but	CC
cord-290004-v3ruj5bq	97	25	could	could	MD
cord-290004-v3ruj5bq	97	26	be	be	VB
cord-290004-v3ruj5bq	97	27	combined	combine	VBN
cord-290004-v3ruj5bq	97	28	with	with	IN
cord-290004-v3ruj5bq	97	29	other	other	JJ
cord-290004-v3ruj5bq	97	30	approaches	approach	NNS
cord-290004-v3ruj5bq	97	31	to	to	TO
cord-290004-v3ruj5bq	97	32	increase	increase	VB
cord-290004-v3ruj5bq	97	33	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	97	34	.	.	.
cord-290004-v3ruj5bq	98	1	HA	HA	NNP
cord-290004-v3ruj5bq	98	2	stalk	stalk	NN
cord-290004-v3ruj5bq	98	3	antibodies	antibody	NNS
cord-290004-v3ruj5bq	98	4	have	have	VBP
cord-290004-v3ruj5bq	98	5	emerged	emerge	VBN
cord-290004-v3ruj5bq	98	6	as	as	IN
cord-290004-v3ruj5bq	98	7	one	one	CD
cord-290004-v3ruj5bq	98	8	of	of	IN
cord-290004-v3ruj5bq	98	9	the	the	DT
cord-290004-v3ruj5bq	98	10	leading	lead	VBG
cord-290004-v3ruj5bq	98	11	strategies	strategy	NNS
cord-290004-v3ruj5bq	98	12	in	in	IN
cord-290004-v3ruj5bq	98	13	the	the	DT
cord-290004-v3ruj5bq	98	14	development	development	NN
cord-290004-v3ruj5bq	98	15	of	of	IN
cord-290004-v3ruj5bq	98	16	universal	universal	JJ
cord-290004-v3ruj5bq	98	17	vaccine	vaccine	NN
cord-290004-v3ruj5bq	98	18	candidates	candidate	NNS
cord-290004-v3ruj5bq	98	19	[	[	-LRB-
cord-290004-v3ruj5bq	98	20	57	57	CD
cord-290004-v3ruj5bq	98	21	]	]	-RRB-
cord-290004-v3ruj5bq	98	22	.	.	.
cord-290004-v3ruj5bq	99	1	Several	several	JJ
cord-290004-v3ruj5bq	99	2	approaches	approach	NNS
cord-290004-v3ruj5bq	99	3	for	for	IN
cord-290004-v3ruj5bq	99	4	avoiding	avoid	VBG
cord-290004-v3ruj5bq	99	5	the	the	DT
cord-290004-v3ruj5bq	99	6	immunodominant	immunodominant	NN
cord-290004-v3ruj5bq	100	1	HA	HA	NNP
cord-290004-v3ruj5bq	100	2	head	head	NN
cord-290004-v3ruj5bq	100	3	domain	domain	NN
cord-290004-v3ruj5bq	100	4	are	be	VBP
cord-290004-v3ruj5bq	100	5	under	under	IN
cord-290004-v3ruj5bq	100	6	development	development	NN
cord-290004-v3ruj5bq	100	7	.	.	.
cord-290004-v3ruj5bq	101	1	One	one	CD
cord-290004-v3ruj5bq	101	2	strategy	strategy	NN
cord-290004-v3ruj5bq	101	3	is	be	VBZ
cord-290004-v3ruj5bq	101	4	to	to	TO
cord-290004-v3ruj5bq	101	5	remove	remove	VB
cord-290004-v3ruj5bq	101	6	the	the	DT
cord-290004-v3ruj5bq	101	7	globular	globular	JJ
cord-290004-v3ruj5bq	101	8	head	head	NN
cord-290004-v3ruj5bq	101	9	domain	domain	NN
cord-290004-v3ruj5bq	101	10	while	while	IN
cord-290004-v3ruj5bq	101	11	maintaining	maintain	VBG
cord-290004-v3ruj5bq	101	12	the	the	DT
cord-290004-v3ruj5bq	101	13	correct	correct	JJ
cord-290004-v3ruj5bq	101	14	immunogenic	immunogenic	JJ
cord-290004-v3ruj5bq	101	15	conformation	conformation	NN
cord-290004-v3ruj5bq	101	16	of	of	IN
cord-290004-v3ruj5bq	101	17	the	the	DT
cord-290004-v3ruj5bq	101	18	HA	HA	NNP
cord-290004-v3ruj5bq	101	19	stalk	stalk	NN
cord-290004-v3ruj5bq	101	20	domain	domain	NN
cord-290004-v3ruj5bq	101	21	[	[	-LRB-
cord-290004-v3ruj5bq	101	22	58	58	CD
cord-290004-v3ruj5bq	101	23	]	]	-RRB-
cord-290004-v3ruj5bq	101	24	.	.	.
cord-290004-v3ruj5bq	102	1	Animal	animal	NN
cord-290004-v3ruj5bq	102	2	models	model	NNS
cord-290004-v3ruj5bq	102	3	have	have	VBP
cord-290004-v3ruj5bq	102	4	shown	show	VBN
cord-290004-v3ruj5bq	102	5	that	that	DT
cord-290004-v3ruj5bq	102	6	vaccination	vaccination	NN
cord-290004-v3ruj5bq	102	7	with	with	IN
cord-290004-v3ruj5bq	102	8	these	these	DT
cord-290004-v3ruj5bq	102	9	"	"	``
cord-290004-v3ruj5bq	102	10	headless	headless	JJ
cord-290004-v3ruj5bq	102	11	"	"	''
cord-290004-v3ruj5bq	102	12	HA	HA	NNP
cord-290004-v3ruj5bq	102	13	proteins	protein	NNS
cord-290004-v3ruj5bq	102	14	can	can	MD
cord-290004-v3ruj5bq	102	15	induce	induce	VB
cord-290004-v3ruj5bq	102	16	heterosubtypic	heterosubtypic	JJ
cord-290004-v3ruj5bq	102	17	protection	protection	NN
cord-290004-v3ruj5bq	102	18	within	within	IN
cord-290004-v3ruj5bq	102	19	group	group	NN
cord-290004-v3ruj5bq	102	20	1	1	CD
cord-290004-v3ruj5bq	102	21	HA	HA	NNP
cord-290004-v3ruj5bq	102	22	proteins	protein	NNS
cord-290004-v3ruj5bq	102	23	[	[	-LRB-
cord-290004-v3ruj5bq	102	24	59	59	CD
cord-290004-v3ruj5bq	102	25	]	]	-RRB-
cord-290004-v3ruj5bq	103	1	[	[	-LRB-
cord-290004-v3ruj5bq	103	2	60	60	CD
cord-290004-v3ruj5bq	103	3	]	]	-RRB-
cord-290004-v3ruj5bq	103	4	[	[	-LRB-
cord-290004-v3ruj5bq	103	5	61	61	CD
cord-290004-v3ruj5bq	103	6	]	]	-RRB-
cord-290004-v3ruj5bq	104	1	[	[	-LRB-
cord-290004-v3ruj5bq	104	2	62	62	CD
cord-290004-v3ruj5bq	104	3	]	]	-RRB-
cord-290004-v3ruj5bq	104	4	.	.	.
cord-290004-v3ruj5bq	105	1	Other	other	JJ
cord-290004-v3ruj5bq	105	2	strategies	strategy	NNS
cord-290004-v3ruj5bq	105	3	for	for	IN
cord-290004-v3ruj5bq	105	4	refocusing	refocus	VBG
cord-290004-v3ruj5bq	105	5	the	the	DT
cord-290004-v3ruj5bq	105	6	antibody	antibody	NN
cord-290004-v3ruj5bq	105	7	response	response	NN
cord-290004-v3ruj5bq	105	8	toward	toward	IN
cord-290004-v3ruj5bq	105	9	the	the	DT
cord-290004-v3ruj5bq	105	10	HA	HA	NNP
cord-290004-v3ruj5bq	105	11	stalk	stalk	NN
cord-290004-v3ruj5bq	105	12	involve	involve	NN
cord-290004-v3ruj5bq	105	13	maintaining	maintain	VBG
cord-290004-v3ruj5bq	105	14	the	the	DT
cord-290004-v3ruj5bq	105	15	full	full	JJ
cord-290004-v3ruj5bq	105	16	-	-	HYPH
cord-290004-v3ruj5bq	105	17	length	length	NN
cord-290004-v3ruj5bq	105	18	HA	HA	NNP
cord-290004-v3ruj5bq	105	19	.	.	.
cord-290004-v3ruj5bq	106	1	Krammer	Krammer	NNP
cord-290004-v3ruj5bq	106	2	and	and	CC
cord-290004-v3ruj5bq	106	3	colleagues	colleague	NNS
cord-290004-v3ruj5bq	106	4	have	have	VBP
cord-290004-v3ruj5bq	106	5	developed	develop	VBN
cord-290004-v3ruj5bq	106	6	a	a	DT
cord-290004-v3ruj5bq	106	7	method	method	NN
cord-290004-v3ruj5bq	106	8	for	for	IN
cord-290004-v3ruj5bq	106	9	directing	direct	VBG
cord-290004-v3ruj5bq	106	10	the	the	DT
cord-290004-v3ruj5bq	106	11	antibody	antibody	NN
cord-290004-v3ruj5bq	106	12	response	response	NN
cord-290004-v3ruj5bq	106	13	to	to	IN
cord-290004-v3ruj5bq	106	14	the	the	DT
cord-290004-v3ruj5bq	106	15	conserved	conserve	VBN
cord-290004-v3ruj5bq	106	16	HA	HA	NNP
cord-290004-v3ruj5bq	106	17	stalk	stalk	NN
cord-290004-v3ruj5bq	106	18	domain	domain	NN
cord-290004-v3ruj5bq	106	19	by	by	IN
cord-290004-v3ruj5bq	106	20	sequential	sequential	JJ
cord-290004-v3ruj5bq	106	21	vaccination	vaccination	NN
cord-290004-v3ruj5bq	106	22	with	with	IN
cord-290004-v3ruj5bq	106	23	chimeric	chimeric	JJ
cord-290004-v3ruj5bq	106	24	HA	HA	NNP
cord-290004-v3ruj5bq	106	25	proteins	protein	NNS
cord-290004-v3ruj5bq	106	26	consisting	consist	VBG
cord-290004-v3ruj5bq	106	27	of	of	IN
cord-290004-v3ruj5bq	106	28	exotic	exotic	JJ
cord-290004-v3ruj5bq	106	29	HA	HA	NNP
cord-290004-v3ruj5bq	106	30	head	head	NN
cord-290004-v3ruj5bq	106	31	domains	domain	NNS
cord-290004-v3ruj5bq	106	32	to	to	TO
cord-290004-v3ruj5bq	106	33	which	which	WDT
cord-290004-v3ruj5bq	106	34	the	the	DT
cord-290004-v3ruj5bq	106	35	recipient	recipient	NN
cord-290004-v3ruj5bq	106	36	is	be	VBZ
cord-290004-v3ruj5bq	106	37	immunologically	immunologically	RB
cord-290004-v3ruj5bq	106	38	naïve	naïve	JJ
cord-290004-v3ruj5bq	106	39	.	.	.
cord-290004-v3ruj5bq	107	1	The	the	DT
cord-290004-v3ruj5bq	107	2	results	result	NNS
cord-290004-v3ruj5bq	107	3	of	of	IN
cord-290004-v3ruj5bq	107	4	a	a	DT
cord-290004-v3ruj5bq	107	5	phase	phase	NN
cord-290004-v3ruj5bq	107	6	1	1	CD
cord-290004-v3ruj5bq	107	7	clinical	clinical	JJ
cord-290004-v3ruj5bq	107	8	trial	trial	NN
cord-290004-v3ruj5bq	107	9	(	(	-LRB-
cord-290004-v3ruj5bq	107	10	NCT03300050	NCT03300050	NNP
cord-290004-v3ruj5bq	107	11	)	)	-RRB-
cord-290004-v3ruj5bq	107	12	provide	provide	VBP
cord-290004-v3ruj5bq	107	13	evidence	evidence	NN
cord-290004-v3ruj5bq	107	14	that	that	IN
cord-290004-v3ruj5bq	107	15	group	group	NN
cord-290004-v3ruj5bq	107	16	1	1	CD
cord-290004-v3ruj5bq	107	17	chimeric	chimeric	JJ
cord-290004-v3ruj5bq	107	18	HA	HA	NNP
cord-290004-v3ruj5bq	107	19	-	-	HYPH
cord-290004-v3ruj5bq	107	20	based	base	VBN
cord-290004-v3ruj5bq	107	21	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	107	22	induce	induce	VBP
cord-290004-v3ruj5bq	107	23	high	high	JJ
cord-290004-v3ruj5bq	107	24	titers	titer	NNS
cord-290004-v3ruj5bq	107	25	of	of	IN
cord-290004-v3ruj5bq	107	26	stalk	stalk	NN
cord-290004-v3ruj5bq	107	27	-	-	HYPH
cord-290004-v3ruj5bq	107	28	reactive	reactive	JJ
cord-290004-v3ruj5bq	107	29	immunoglobulin	immunoglobulin	NN
cord-290004-v3ruj5bq	107	30	G	g	NN
cord-290004-v3ruj5bq	107	31	(	(	-LRB-
cord-290004-v3ruj5bq	107	32	IgG	IgG	NNP
cord-290004-v3ruj5bq	107	33	)	)	-RRB-
cord-290004-v3ruj5bq	107	34	that	that	WDT
cord-290004-v3ruj5bq	107	35	cross	cross	NN
cord-290004-v3ruj5bq	107	36	-	-	NN
cord-290004-v3ruj5bq	107	37	react	react	VB
cord-290004-v3ruj5bq	107	38	to	to	IN
cord-290004-v3ruj5bq	107	39	other	other	JJ
cord-290004-v3ruj5bq	107	40	HA	HA	NNP
cord-290004-v3ruj5bq	107	41	proteins	protein	NNS
cord-290004-v3ruj5bq	107	42	within	within	IN
cord-290004-v3ruj5bq	107	43	the	the	DT
cord-290004-v3ruj5bq	107	44	same	same	JJ
cord-290004-v3ruj5bq	107	45	group	group	NN
cord-290004-v3ruj5bq	107	46	[	[	-LRB-
cord-290004-v3ruj5bq	107	47	63	63	CD
cord-290004-v3ruj5bq	107	48	]	]	-RRB-
cord-290004-v3ruj5bq	107	49	.	.	.
cord-290004-v3ruj5bq	108	1	A	a	DT
cord-290004-v3ruj5bq	108	2	trivalent	trivalent	JJ
cord-290004-v3ruj5bq	108	3	vaccine	vaccine	NN
cord-290004-v3ruj5bq	108	4	comprising	comprise	VBG
cord-290004-v3ruj5bq	108	5	group	group	NN
cord-290004-v3ruj5bq	108	6	1	1	CD
cord-290004-v3ruj5bq	108	7	,	,	,
cord-290004-v3ruj5bq	108	8	group	group	NN
cord-290004-v3ruj5bq	108	9	2	2	CD
cord-290004-v3ruj5bq	108	10	,	,	,
cord-290004-v3ruj5bq	108	11	and	and	CC
cord-290004-v3ruj5bq	108	12	influenza	influenza	NN
cord-290004-v3ruj5bq	108	13	B	b	NN
cord-290004-v3ruj5bq	108	14	virus	virus	NN
cord-290004-v3ruj5bq	108	15	chimeric	chimeric	JJ
cord-290004-v3ruj5bq	108	16	constructs	construct	NNS
cord-290004-v3ruj5bq	108	17	could	could	MD
cord-290004-v3ruj5bq	108	18	potentially	potentially	RB
cord-290004-v3ruj5bq	108	19	lead	lead	VB
cord-290004-v3ruj5bq	108	20	to	to	IN
cord-290004-v3ruj5bq	108	21	a	a	DT
cord-290004-v3ruj5bq	108	22	universal	universal	JJ
cord-290004-v3ruj5bq	108	23	influenza	influenza	NN
cord-290004-v3ruj5bq	108	24	vaccine	vaccine	NN
cord-290004-v3ruj5bq	108	25	.	.	.
cord-290004-v3ruj5bq	109	1	Advances	advance	NNS
cord-290004-v3ruj5bq	109	2	in	in	IN
cord-290004-v3ruj5bq	109	3	the	the	DT
cord-290004-v3ruj5bq	109	4	development	development	NN
cord-290004-v3ruj5bq	109	5	of	of	IN
cord-290004-v3ruj5bq	109	6	monoclonal	monoclonal	JJ
cord-290004-v3ruj5bq	109	7	antibodies	antibody	NNS
cord-290004-v3ruj5bq	109	8	(	(	-LRB-
cord-290004-v3ruj5bq	109	9	mAbs	mAbs	NNP
cord-290004-v3ruj5bq	109	10	)	)	-RRB-
cord-290004-v3ruj5bq	109	11	have	have	VBP
cord-290004-v3ruj5bq	109	12	shown	show	VBN
cord-290004-v3ruj5bq	109	13	that	that	IN
cord-290004-v3ruj5bq	109	14	there	there	EX
cord-290004-v3ruj5bq	109	15	are	be	VBP
cord-290004-v3ruj5bq	109	16	cross	cross	JJ
cord-290004-v3ruj5bq	109	17	-	-	JJ
cord-290004-v3ruj5bq	109	18	reactive	reactive	JJ
cord-290004-v3ruj5bq	109	19	epitopes	epitope	NNS
cord-290004-v3ruj5bq	109	20	on	on	IN
cord-290004-v3ruj5bq	109	21	the	the	DT
cord-290004-v3ruj5bq	109	22	HA	HA	NNP
cord-290004-v3ruj5bq	109	23	head	head	NN
cord-290004-v3ruj5bq	109	24	domain	domain	NN
cord-290004-v3ruj5bq	109	25	that	that	WDT
cord-290004-v3ruj5bq	109	26	can	can	MD
cord-290004-v3ruj5bq	109	27	be	be	VB
cord-290004-v3ruj5bq	109	28	targeted	target	VBN
cord-290004-v3ruj5bq	109	29	to	to	TO
cord-290004-v3ruj5bq	109	30	give	give	VB
cord-290004-v3ruj5bq	109	31	heterosubtypic	heterosubtypic	JJ
cord-290004-v3ruj5bq	109	32	protection	protection	NN
cord-290004-v3ruj5bq	109	33	[	[	-LRB-
cord-290004-v3ruj5bq	109	34	64	64	CD
cord-290004-v3ruj5bq	109	35	]	]	-RRB-
cord-290004-v3ruj5bq	110	1	[	[	-LRB-
cord-290004-v3ruj5bq	110	2	65	65	CD
cord-290004-v3ruj5bq	110	3	]	]	-RRB-
cord-290004-v3ruj5bq	110	4	[	[	-LRB-
cord-290004-v3ruj5bq	110	5	66	66	CD
cord-290004-v3ruj5bq	110	6	]	]	-RRB-
cord-290004-v3ruj5bq	110	7	.	.	.
cord-290004-v3ruj5bq	111	1	A	a	DT
cord-290004-v3ruj5bq	111	2	new	new	JJ
cord-290004-v3ruj5bq	111	3	vaccine	vaccine	NN
cord-290004-v3ruj5bq	111	4	approach	approach	NN
cord-290004-v3ruj5bq	111	5	called	call	VBN
cord-290004-v3ruj5bq	111	6	mosaic	mosaic	JJ
cord-290004-v3ruj5bq	111	7	HA	HA	NNP
cord-290004-v3ruj5bq	111	8	has	have	VBZ
cord-290004-v3ruj5bq	111	9	been	be	VBN
cord-290004-v3ruj5bq	111	10	developed	develop	VBN
cord-290004-v3ruj5bq	111	11	to	to	TO
cord-290004-v3ruj5bq	111	12	combine	combine	VB
cord-290004-v3ruj5bq	111	13	the	the	DT
cord-290004-v3ruj5bq	111	14	immunity	immunity	NN
cord-290004-v3ruj5bq	111	15	of	of	IN
cord-290004-v3ruj5bq	111	16	conserved	conserved	JJ
cord-290004-v3ruj5bq	111	17	epitopes	epitope	NNS
cord-290004-v3ruj5bq	111	18	of	of	IN
cord-290004-v3ruj5bq	111	19	the	the	DT
cord-290004-v3ruj5bq	111	20	HA	HA	NNP
cord-290004-v3ruj5bq	111	21	stalk	stalk	NN
cord-290004-v3ruj5bq	111	22	and	and	CC
cord-290004-v3ruj5bq	111	23	head	head	NN
cord-290004-v3ruj5bq	111	24	domains	domain	NNS
cord-290004-v3ruj5bq	111	25	.	.	.
cord-290004-v3ruj5bq	112	1	Mosaic	Mosaic	NNP
cord-290004-v3ruj5bq	112	2	HA	HA	NNP
cord-290004-v3ruj5bq	112	3	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	112	4	are	be	VBP
cord-290004-v3ruj5bq	112	5	developed	develop	VBN
cord-290004-v3ruj5bq	112	6	by	by	IN
cord-290004-v3ruj5bq	112	7	replacing	replace	VBG
cord-290004-v3ruj5bq	112	8	the	the	DT
cord-290004-v3ruj5bq	112	9	immunodominant	immunodominant	NN
cord-290004-v3ruj5bq	112	10	and	and	CC
cord-290004-v3ruj5bq	112	11	strain	strain	NN
cord-290004-v3ruj5bq	112	12	-	-	HYPH
cord-290004-v3ruj5bq	112	13	specific	specific	JJ
cord-290004-v3ruj5bq	112	14	antigenic	antigenic	JJ
cord-290004-v3ruj5bq	112	15	sites	site	NNS
cord-290004-v3ruj5bq	112	16	with	with	IN
cord-290004-v3ruj5bq	112	17	sequences	sequence	NNS
cord-290004-v3ruj5bq	112	18	from	from	IN
cord-290004-v3ruj5bq	112	19	exotic	exotic	JJ
cord-290004-v3ruj5bq	112	20	HA	HA	NNP
cord-290004-v3ruj5bq	112	21	subtypes	subtype	NNS
cord-290004-v3ruj5bq	112	22	.	.	.
cord-290004-v3ruj5bq	113	1	Through	through	IN
cord-290004-v3ruj5bq	113	2	sequential	sequential	JJ
cord-290004-v3ruj5bq	113	3	immunization	immunization	NN
cord-290004-v3ruj5bq	113	4	,	,	,
cord-290004-v3ruj5bq	113	5	the	the	DT
cord-290004-v3ruj5bq	113	6	immune	immune	JJ
cord-290004-v3ruj5bq	113	7	response	response	NN
cord-290004-v3ruj5bq	113	8	is	be	VBZ
cord-290004-v3ruj5bq	113	9	refocused	refocus	VBN
cord-290004-v3ruj5bq	113	10	toward	toward	IN
cord-290004-v3ruj5bq	113	11	more	more	JJR
cord-290004-v3ruj5bq	113	12	cross	cross	JJ
cord-290004-v3ruj5bq	113	13	-	-	JJ
cord-290004-v3ruj5bq	113	14	reactive	reactive	JJ
cord-290004-v3ruj5bq	113	15	immunosubdominant	immunosubdominant	NN
cord-290004-v3ruj5bq	113	16	epitopes	epitope	NNS
cord-290004-v3ruj5bq	113	17	of	of	IN
cord-290004-v3ruj5bq	113	18	the	the	DT
cord-290004-v3ruj5bq	113	19	HA	HA	NNP
cord-290004-v3ruj5bq	113	20	stalk	stalk	NN
cord-290004-v3ruj5bq	113	21	and	and	CC
cord-290004-v3ruj5bq	113	22	head	head	NN
cord-290004-v3ruj5bq	113	23	domains	domain	NNS
cord-290004-v3ruj5bq	113	24	.	.	.
cord-290004-v3ruj5bq	114	1	Cross	cross	JJ
cord-290004-v3ruj5bq	114	2	-	-	JJ
cord-290004-v3ruj5bq	114	3	reactive	reactive	JJ
cord-290004-v3ruj5bq	114	4	HA	HA	NNP
cord-290004-v3ruj5bq	114	5	stalk	stalk	NN
cord-290004-v3ruj5bq	114	6	-	-	HYPH
cord-290004-v3ruj5bq	114	7	and	and	CC
cord-290004-v3ruj5bq	114	8	head	head	NN
cord-290004-v3ruj5bq	114	9	-	-	HYPH
cord-290004-v3ruj5bq	114	10	specific	specific	JJ
cord-290004-v3ruj5bq	114	11	antibodies	antibody	NNS
cord-290004-v3ruj5bq	114	12	can	can	MD
cord-290004-v3ruj5bq	114	13	also	also	RB
cord-290004-v3ruj5bq	114	14	be	be	VB
cord-290004-v3ruj5bq	114	15	induced	induce	VBN
cord-290004-v3ruj5bq	114	16	by	by	IN
cord-290004-v3ruj5bq	114	17	computationally	computationally	RB
cord-290004-v3ruj5bq	114	18	optimized	optimize	VBN
cord-290004-v3ruj5bq	114	19	,	,	,
cord-290004-v3ruj5bq	114	20	broadly	broadly	RB
cord-290004-v3ruj5bq	114	21	reactive	reactive	JJ
cord-290004-v3ruj5bq	114	22	antigens	antigen	NNS
cord-290004-v3ruj5bq	114	23	(	(	-LRB-
cord-290004-v3ruj5bq	114	24	COBRAs	COBRAs	NNPS
cord-290004-v3ruj5bq	114	25	)	)	-RRB-
cord-290004-v3ruj5bq	114	26	.	.	.
cord-290004-v3ruj5bq	115	1	This	this	DT
cord-290004-v3ruj5bq	115	2	approach	approach	NN
cord-290004-v3ruj5bq	115	3	is	be	VBZ
cord-290004-v3ruj5bq	115	4	based	base	VBN
cord-290004-v3ruj5bq	115	5	on	on	IN
cord-290004-v3ruj5bq	115	6	developing	develop	VBG
cord-290004-v3ruj5bq	115	7	novel	novel	NN
cord-290004-v3ruj5bq	115	8	HA	HA	NNP
cord-290004-v3ruj5bq	115	9	proteins	protein	NNS
cord-290004-v3ruj5bq	115	10	after	after	IN
cord-290004-v3ruj5bq	115	11	multiple	multiple	JJ
cord-290004-v3ruj5bq	115	12	rounds	round	NNS
cord-290004-v3ruj5bq	115	13	of	of	IN
cord-290004-v3ruj5bq	115	14	consensus	consensus	NN
cord-290004-v3ruj5bq	115	15	sequence	sequence	NN
cord-290004-v3ruj5bq	115	16	generation	generation	NN
cord-290004-v3ruj5bq	115	17	from	from	IN
cord-290004-v3ruj5bq	115	18	a	a	DT
cord-290004-v3ruj5bq	115	19	variety	variety	NN
cord-290004-v3ruj5bq	115	20	of	of	IN
cord-290004-v3ruj5bq	115	21	different	different	JJ
cord-290004-v3ruj5bq	115	22	HA	HA	NNP
cord-290004-v3ruj5bq	115	23	isolates	isolate	NNS
cord-290004-v3ruj5bq	115	24	.	.	.
cord-290004-v3ruj5bq	116	1	Preclinical	preclinical	JJ
cord-290004-v3ruj5bq	116	2	trials	trial	NNS
cord-290004-v3ruj5bq	116	3	have	have	VBP
cord-290004-v3ruj5bq	116	4	demonstrated	demonstrate	VBN
cord-290004-v3ruj5bq	116	5	that	that	IN
cord-290004-v3ruj5bq	116	6	COBRA	COBRA	NNP
cord-290004-v3ruj5bq	116	7	-	-	HYPH
cord-290004-v3ruj5bq	116	8	based	base	VBN
cord-290004-v3ruj5bq	116	9	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	116	10	provide	provide	VBP
cord-290004-v3ruj5bq	116	11	protection	protection	NN
cord-290004-v3ruj5bq	116	12	against	against	IN
cord-290004-v3ruj5bq	116	13	multiple	multiple	JJ
cord-290004-v3ruj5bq	116	14	influenza	influenza	NN
cord-290004-v3ruj5bq	116	15	viruses	virus	NNS
cord-290004-v3ruj5bq	116	16	within	within	IN
cord-290004-v3ruj5bq	116	17	a	a	DT
cord-290004-v3ruj5bq	116	18	subtype	subtype	NN
cord-290004-v3ruj5bq	116	19	in	in	IN
cord-290004-v3ruj5bq	116	20	murine	murine	JJ
cord-290004-v3ruj5bq	116	21	and	and	CC
cord-290004-v3ruj5bq	116	22	ferret	ferret	JJ
cord-290004-v3ruj5bq	116	23	models	model	NNS
cord-290004-v3ruj5bq	116	24	[	[	-LRB-
cord-290004-v3ruj5bq	116	25	67	67	CD
cord-290004-v3ruj5bq	116	26	]	]	-RRB-
cord-290004-v3ruj5bq	116	27	[	[	-LRB-
cord-290004-v3ruj5bq	116	28	68	68	CD
cord-290004-v3ruj5bq	116	29	]	]	-RRB-
cord-290004-v3ruj5bq	116	30	[	[	-LRB-
cord-290004-v3ruj5bq	116	31	69	69	CD
cord-290004-v3ruj5bq	116	32	]	]	-RRB-
cord-290004-v3ruj5bq	116	33	.	.	.
cord-290004-v3ruj5bq	117	1	There	there	EX
cord-290004-v3ruj5bq	117	2	has	have	VBZ
cord-290004-v3ruj5bq	117	3	been	be	VBN
cord-290004-v3ruj5bq	117	4	increased	increase	VBN
cord-290004-v3ruj5bq	117	5	recognition	recognition	NN
cord-290004-v3ruj5bq	117	6	of	of	IN
cord-290004-v3ruj5bq	117	7	NA	NA	NNP
cord-290004-v3ruj5bq	117	8	as	as	IN
cord-290004-v3ruj5bq	117	9	a	a	DT
cord-290004-v3ruj5bq	117	10	target	target	NN
cord-290004-v3ruj5bq	117	11	for	for	IN
cord-290004-v3ruj5bq	117	12	improved	improved	JJ
cord-290004-v3ruj5bq	117	13	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	117	14	following	follow	VBG
cord-290004-v3ruj5bq	117	15	the	the	DT
cord-290004-v3ruj5bq	117	16	development	development	NN
cord-290004-v3ruj5bq	117	17	of	of	IN
cord-290004-v3ruj5bq	117	18	practical	practical	JJ
cord-290004-v3ruj5bq	117	19	assays	assay	NNS
cord-290004-v3ruj5bq	117	20	for	for	IN
cord-290004-v3ruj5bq	117	21	measuring	measure	VBG
cord-290004-v3ruj5bq	117	22	antibody	antibody	NN
cord-290004-v3ruj5bq	117	23	responses	response	NNS
cord-290004-v3ruj5bq	117	24	to	to	IN
cord-290004-v3ruj5bq	117	25	NA	NA	NNP
cord-290004-v3ruj5bq	117	26	[	[	-LRB-
cord-290004-v3ruj5bq	117	27	11	11	CD
cord-290004-v3ruj5bq	117	28	]	]	-RRB-
cord-290004-v3ruj5bq	117	29	.	.	.
cord-290004-v3ruj5bq	118	1	Although	although	IN
cord-290004-v3ruj5bq	118	2	antibodies	antibody	NNS
cord-290004-v3ruj5bq	118	3	targeting	target	VBG
cord-290004-v3ruj5bq	118	4	NA	NA	NNP
cord-290004-v3ruj5bq	118	5	can	can	MD
cord-290004-v3ruj5bq	118	6	bind	bind	VB
cord-290004-v3ruj5bq	118	7	to	to	IN
cord-290004-v3ruj5bq	118	8	conserved	conserved	JJ
cord-290004-v3ruj5bq	118	9	epitopes	epitope	NNS
cord-290004-v3ruj5bq	118	10	and	and	CC
cord-290004-v3ruj5bq	118	11	provide	provide	VB
cord-290004-v3ruj5bq	118	12	heterologous	heterologous	JJ
cord-290004-v3ruj5bq	118	13	protection	protection	NN
cord-290004-v3ruj5bq	118	14	[	[	-LRB-
cord-290004-v3ruj5bq	118	15	16	16	CD
cord-290004-v3ruj5bq	118	16	]	]	-RRB-
cord-290004-v3ruj5bq	118	17	,	,	,
cord-290004-v3ruj5bq	118	18	they	-PRON-	PRP
cord-290004-v3ruj5bq	118	19	are	be	VBP
cord-290004-v3ruj5bq	118	20	not	not	RB
cord-290004-v3ruj5bq	118	21	really	really	RB
cord-290004-v3ruj5bq	118	22	induced	induce	VBN
cord-290004-v3ruj5bq	118	23	by	by	IN
cord-290004-v3ruj5bq	118	24	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	118	25	IIVs	iiv	NNS
cord-290004-v3ruj5bq	118	26	.	.	.
cord-290004-v3ruj5bq	119	1	This	this	DT
cord-290004-v3ruj5bq	119	2	is	be	VBZ
cord-290004-v3ruj5bq	119	3	mostly	mostly	RB
cord-290004-v3ruj5bq	119	4	due	due	JJ
cord-290004-v3ruj5bq	119	5	to	to	IN
cord-290004-v3ruj5bq	119	6	the	the	DT
cord-290004-v3ruj5bq	119	7	amount	amount	NN
cord-290004-v3ruj5bq	119	8	and	and	CC
cord-290004-v3ruj5bq	119	9	stability	stability	NN
cord-290004-v3ruj5bq	119	10	of	of	IN
cord-290004-v3ruj5bq	119	11	the	the	DT
cord-290004-v3ruj5bq	119	12	NA	NA	NNP
cord-290004-v3ruj5bq	119	13	in	in	IN
cord-290004-v3ruj5bq	119	14	the	the	DT
cord-290004-v3ruj5bq	119	15	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	119	16	.	.	.
cord-290004-v3ruj5bq	120	1	Enhanced	enhanced	JJ
cord-290004-v3ruj5bq	120	2	NA	na	NN
cord-290004-v3ruj5bq	120	3	-	-	HYPH
cord-290004-v3ruj5bq	120	4	antibody	antibody	NN
cord-290004-v3ruj5bq	120	5	responses	response	NNS
cord-290004-v3ruj5bq	120	6	can	can	MD
cord-290004-v3ruj5bq	120	7	be	be	VB
cord-290004-v3ruj5bq	120	8	achieved	achieve	VBN
cord-290004-v3ruj5bq	120	9	by	by	IN
cord-290004-v3ruj5bq	120	10	delivering	deliver	VBG
cord-290004-v3ruj5bq	120	11	NA	NA	NNP
cord-290004-v3ruj5bq	120	12	as	as	IN
cord-290004-v3ruj5bq	120	13	a	a	DT
cord-290004-v3ruj5bq	120	14	supplement	supplement	NN
cord-290004-v3ruj5bq	120	15	to	to	IN
cord-290004-v3ruj5bq	120	16	current	current	JJ
cord-290004-v3ruj5bq	120	17	IIVs	iiv	NNS
cord-290004-v3ruj5bq	120	18	or	or	CC
cord-290004-v3ruj5bq	120	19	vaccinating	vaccinate	VBG
cord-290004-v3ruj5bq	120	20	with	with	IN
cord-290004-v3ruj5bq	120	21	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	120	22	or	or	CC
cord-290004-v3ruj5bq	120	23	viral	viral	JJ
cord-290004-v3ruj5bq	120	24	vector	vector	NN
cord-290004-v3ruj5bq	120	25	NA	NA	NNP
cord-290004-v3ruj5bq	120	26	in	in	IN
cord-290004-v3ruj5bq	120	27	addition	addition	NN
cord-290004-v3ruj5bq	120	28	to	to	IN
cord-290004-v3ruj5bq	120	29	the	the	DT
cord-290004-v3ruj5bq	120	30	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	120	31	IIVs	iiv	NNS
cord-290004-v3ruj5bq	120	32	[	[	-LRB-
cord-290004-v3ruj5bq	120	33	70	70	CD
cord-290004-v3ruj5bq	120	34	]	]	-RRB-
cord-290004-v3ruj5bq	120	35	[	[	-LRB-
cord-290004-v3ruj5bq	120	36	71	71	CD
cord-290004-v3ruj5bq	120	37	]	]	-RRB-
cord-290004-v3ruj5bq	120	38	[	[	-LRB-
cord-290004-v3ruj5bq	120	39	72	72	CD
cord-290004-v3ruj5bq	120	40	]	]	-RRB-
cord-290004-v3ruj5bq	120	41	[	[	-LRB-
cord-290004-v3ruj5bq	120	42	73	73	CD
cord-290004-v3ruj5bq	120	43	]	]	-RRB-
cord-290004-v3ruj5bq	120	44	[	[	-LRB-
cord-290004-v3ruj5bq	120	45	74	74	CD
cord-290004-v3ruj5bq	120	46	]	]	-RRB-
cord-290004-v3ruj5bq	120	47	.	.	.
cord-290004-v3ruj5bq	121	1	M2e	M2e	NNP
cord-290004-v3ruj5bq	121	2	has	have	VBZ
cord-290004-v3ruj5bq	121	3	been	be	VBN
cord-290004-v3ruj5bq	121	4	an	an	DT
cord-290004-v3ruj5bq	121	5	attractive	attractive	JJ
cord-290004-v3ruj5bq	121	6	target	target	NN
cord-290004-v3ruj5bq	121	7	in	in	IN
cord-290004-v3ruj5bq	121	8	the	the	DT
cord-290004-v3ruj5bq	121	9	development	development	NN
cord-290004-v3ruj5bq	121	10	of	of	IN
cord-290004-v3ruj5bq	121	11	the	the	DT
cord-290004-v3ruj5bq	121	12	future	future	JJ
cord-290004-v3ruj5bq	121	13	universal	universal	JJ
cord-290004-v3ruj5bq	121	14	influenza	influenza	NN
cord-290004-v3ruj5bq	121	15	vaccine	vaccine	NN
cord-290004-v3ruj5bq	121	16	,	,	,
cord-290004-v3ruj5bq	121	17	as	as	IN
cord-290004-v3ruj5bq	121	18	it	-PRON-	PRP
cord-290004-v3ruj5bq	121	19	is	be	VBZ
cord-290004-v3ruj5bq	121	20	highly	highly	RB
cord-290004-v3ruj5bq	121	21	conserved	conserve	VBN
cord-290004-v3ruj5bq	121	22	between	between	IN
cord-290004-v3ruj5bq	121	23	influenza	influenza	NN
cord-290004-v3ruj5bq	121	24	viruses	virus	NNS
cord-290004-v3ruj5bq	121	25	[	[	-LRB-
cord-290004-v3ruj5bq	121	26	75	75	CD
cord-290004-v3ruj5bq	121	27	]	]	-RRB-
cord-290004-v3ruj5bq	121	28	.	.	.
cord-290004-v3ruj5bq	122	1	Because	because	IN
cord-290004-v3ruj5bq	122	2	of	of	IN
cord-290004-v3ruj5bq	122	3	the	the	DT
cord-290004-v3ruj5bq	122	4	relatively	relatively	RB
cord-290004-v3ruj5bq	122	5	small	small	JJ
cord-290004-v3ruj5bq	122	6	size	size	NN
cord-290004-v3ruj5bq	122	7	of	of	IN
cord-290004-v3ruj5bq	122	8	the	the	DT
cord-290004-v3ruj5bq	122	9	M2e	M2e	NNS
cord-290004-v3ruj5bq	122	10	,	,	,
cord-290004-v3ruj5bq	122	11	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	122	12	usually	usually	RB
cord-290004-v3ruj5bq	122	13	depend	depend	VBP
cord-290004-v3ruj5bq	122	14	on	on	IN
cord-290004-v3ruj5bq	122	15	carrier	carrier	NN
cord-290004-v3ruj5bq	122	16	constructs	construct	NNS
cord-290004-v3ruj5bq	122	17	such	such	JJ
cord-290004-v3ruj5bq	122	18	as	as	IN
cord-290004-v3ruj5bq	122	19	VLPs	vlp	NNS
cord-290004-v3ruj5bq	122	20	.	.	.
cord-290004-v3ruj5bq	123	1	Preclinical	preclinical	JJ
cord-290004-v3ruj5bq	123	2	trials	trial	NNS
cord-290004-v3ruj5bq	123	3	have	have	VBP
cord-290004-v3ruj5bq	123	4	demonstrated	demonstrate	VBN
cord-290004-v3ruj5bq	123	5	that	that	IN
cord-290004-v3ruj5bq	123	6	M2e	M2e	NNP
cord-290004-v3ruj5bq	123	7	antibodies	antibody	NNS
cord-290004-v3ruj5bq	123	8	are	be	VBP
cord-290004-v3ruj5bq	123	9	protective	protective	JJ
cord-290004-v3ruj5bq	123	10	in	in	IN
cord-290004-v3ruj5bq	123	11	animal	animal	NN
cord-290004-v3ruj5bq	123	12	models	model	NNS
cord-290004-v3ruj5bq	123	13	,	,	,
cord-290004-v3ruj5bq	123	14	and	and	CC
cord-290004-v3ruj5bq	123	15	some	some	DT
cord-290004-v3ruj5bq	123	16	M2e	M2e	VBG
cord-290004-v3ruj5bq	123	17	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	123	18	have	have	VBP
cord-290004-v3ruj5bq	123	19	advanced	advance	VBN
cord-290004-v3ruj5bq	123	20	into	into	IN
cord-290004-v3ruj5bq	123	21	clinical	clinical	JJ
cord-290004-v3ruj5bq	123	22	trials	trial	NNS
cord-290004-v3ruj5bq	123	23	[	[	-LRB-
cord-290004-v3ruj5bq	123	24	76	76	CD
cord-290004-v3ruj5bq	123	25	,	,	,
cord-290004-v3ruj5bq	123	26	77	77	CD
cord-290004-v3ruj5bq	123	27	]	]	-RRB-
cord-290004-v3ruj5bq	123	28	.	.	.
cord-290004-v3ruj5bq	124	1	While	while	IN
cord-290004-v3ruj5bq	124	2	the	the	DT
cord-290004-v3ruj5bq	124	3	effectiveness	effectiveness	NN
cord-290004-v3ruj5bq	124	4	of	of	IN
cord-290004-v3ruj5bq	124	5	a	a	DT
cord-290004-v3ruj5bq	124	6	stand	stand	VB
cord-290004-v3ruj5bq	124	7	-	-	HYPH
cord-290004-v3ruj5bq	124	8	alone	alone	RB
cord-290004-v3ruj5bq	124	9	M2e	m2e	NN
cord-290004-v3ruj5bq	124	10	-	-	HYPH
cord-290004-v3ruj5bq	124	11	based	base	VBN
cord-290004-v3ruj5bq	124	12	vaccine	vaccine	NN
cord-290004-v3ruj5bq	124	13	remains	remain	VBZ
cord-290004-v3ruj5bq	124	14	limited	limited	JJ
cord-290004-v3ruj5bq	124	15	,	,	,
cord-290004-v3ruj5bq	124	16	recent	recent	JJ
cord-290004-v3ruj5bq	124	17	studies	study	NNS
cord-290004-v3ruj5bq	124	18	have	have	VBP
cord-290004-v3ruj5bq	124	19	found	find	VBN
cord-290004-v3ruj5bq	124	20	promising	promising	JJ
cord-290004-v3ruj5bq	124	21	results	result	NNS
cord-290004-v3ruj5bq	124	22	by	by	IN
cord-290004-v3ruj5bq	124	23	combining	combine	VBG
cord-290004-v3ruj5bq	124	24	an	an	DT
cord-290004-v3ruj5bq	124	25	M2e	m2e	NN
cord-290004-v3ruj5bq	124	26	-	-	HYPH
cord-290004-v3ruj5bq	124	27	based	base	VBN
cord-290004-v3ruj5bq	124	28	vaccine	vaccine	NN
cord-290004-v3ruj5bq	124	29	(	(	-LRB-
cord-290004-v3ruj5bq	124	30	M2e5x	M2e5x	NNP
cord-290004-v3ruj5bq	124	31	VLP	VLP	NNP
cord-290004-v3ruj5bq	124	32	)	)	-RRB-
cord-290004-v3ruj5bq	124	33	with	with	IN
cord-290004-v3ruj5bq	124	34	other	other	JJ
cord-290004-v3ruj5bq	124	35	vaccine	vaccine	NN
cord-290004-v3ruj5bq	124	36	constructs	construct	NNS
cord-290004-v3ruj5bq	124	37	such	such	JJ
cord-290004-v3ruj5bq	124	38	as	as	IN
cord-290004-v3ruj5bq	124	39	LAIVs	laiv	NNS
cord-290004-v3ruj5bq	124	40	[	[	-LRB-
cord-290004-v3ruj5bq	124	41	78	78	CD
cord-290004-v3ruj5bq	124	42	]	]	-RRB-
cord-290004-v3ruj5bq	124	43	and	and	CC
cord-290004-v3ruj5bq	124	44	HA	HA	NNP
cord-290004-v3ruj5bq	124	45	VLPs	VLPs	NNP
cord-290004-v3ruj5bq	124	46	[	[	-LRB-
cord-290004-v3ruj5bq	124	47	79	79	CD
cord-290004-v3ruj5bq	124	48	]	]	-RRB-
cord-290004-v3ruj5bq	124	49	.	.	.
cord-290004-v3ruj5bq	125	1	Most	Most	JJS
cord-290004-v3ruj5bq	125	2	vaccine	vaccine	NN
cord-290004-v3ruj5bq	125	3	approaches	approach	VBZ
cord-290004-v3ruj5bq	125	4	targeting	target	VBG
cord-290004-v3ruj5bq	125	5	internal	internal	JJ
cord-290004-v3ruj5bq	125	6	proteins	protein	NNS
cord-290004-v3ruj5bq	125	7	such	such	JJ
cord-290004-v3ruj5bq	125	8	as	as	IN
cord-290004-v3ruj5bq	125	9	M1	M1	NNP
cord-290004-v3ruj5bq	125	10	and	and	CC
cord-290004-v3ruj5bq	125	11	NP	NP	NNP
cord-290004-v3ruj5bq	125	12	involve	involve	VBP
cord-290004-v3ruj5bq	125	13	T	t	NN
cord-290004-v3ruj5bq	125	14	-	-	HYPH
cord-290004-v3ruj5bq	125	15	cell	cell	NN
cord-290004-v3ruj5bq	125	16	activation	activation	NN
cord-290004-v3ruj5bq	125	17	.	.	.
cord-290004-v3ruj5bq	126	1	T	t	NN
cord-290004-v3ruj5bq	126	2	cells	cell	NNS
cord-290004-v3ruj5bq	126	3	are	be	VBP
cord-290004-v3ruj5bq	126	4	important	important	JJ
cord-290004-v3ruj5bq	126	5	during	during	IN
cord-290004-v3ruj5bq	126	6	an	an	DT
cord-290004-v3ruj5bq	126	7	influenza	influenza	NN
cord-290004-v3ruj5bq	126	8	infection	infection	NN
cord-290004-v3ruj5bq	126	9	because	because	IN
cord-290004-v3ruj5bq	126	10	they	-PRON-	PRP
cord-290004-v3ruj5bq	126	11	limit	limit	VBP
cord-290004-v3ruj5bq	126	12	viral	viral	JJ
cord-290004-v3ruj5bq	126	13	replication	replication	NN
cord-290004-v3ruj5bq	126	14	and	and	CC
cord-290004-v3ruj5bq	126	15	shedding	shed	VBG
cord-290004-v3ruj5bq	126	16	by	by	IN
cord-290004-v3ruj5bq	126	17	clearing	clear	VBG
cord-290004-v3ruj5bq	126	18	influenza	influenza	NN
cord-290004-v3ruj5bq	126	19	-	-	HYPH
cord-290004-v3ruj5bq	126	20	infected	infect	VBN
cord-290004-v3ruj5bq	126	21	cells	cell	NNS
cord-290004-v3ruj5bq	126	22	.	.	.
cord-290004-v3ruj5bq	127	1	An	an	DT
cord-290004-v3ruj5bq	127	2	ongoing	ongoing	JJ
cord-290004-v3ruj5bq	127	3	phase	phase	NN
cord-290004-v3ruj5bq	127	4	3	3	CD
cord-290004-v3ruj5bq	127	5	clinical	clinical	JJ
cord-290004-v3ruj5bq	127	6	trial	trial	NN
cord-290004-v3ruj5bq	127	7	(	(	-LRB-
cord-290004-v3ruj5bq	127	8	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-290004-v3ruj5bq	127	9	:	:	:
cord-290004-v3ruj5bq	127	10	NCT03450915	NCT03450915	NNP
cord-290004-v3ruj5bq	127	11	)	)	-RRB-
cord-290004-v3ruj5bq	127	12	is	be	VBZ
cord-290004-v3ruj5bq	127	13	testing	test	VBG
cord-290004-v3ruj5bq	127	14	a	a	DT
cord-290004-v3ruj5bq	127	15	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	127	16	-	-	HYPH
cord-290004-v3ruj5bq	127	17	peptide	peptide	JJ
cord-290004-v3ruj5bq	127	18	based	base	VBN
cord-290004-v3ruj5bq	127	19	vaccine	vaccine	NN
cord-290004-v3ruj5bq	127	20	consisting	consist	VBG
cord-290004-v3ruj5bq	127	21	of	of	IN
cord-290004-v3ruj5bq	127	22	conserved	conserved	JJ
cord-290004-v3ruj5bq	127	23	epitopes	epitope	NNS
cord-290004-v3ruj5bq	127	24	from	from	IN
cord-290004-v3ruj5bq	127	25	HA	HA	NNP
cord-290004-v3ruj5bq	127	26	,	,	,
cord-290004-v3ruj5bq	127	27	NP	NP	NNP
cord-290004-v3ruj5bq	127	28	,	,	,
cord-290004-v3ruj5bq	127	29	and	and	CC
cord-290004-v3ruj5bq	127	30	M1	M1	NNP
cord-290004-v3ruj5bq	127	31	[	[	-LRB-
cord-290004-v3ruj5bq	127	32	80	80	CD
cord-290004-v3ruj5bq	127	33	]	]	-RRB-
cord-290004-v3ruj5bq	127	34	.	.	.
cord-290004-v3ruj5bq	128	1	Other	other	JJ
cord-290004-v3ruj5bq	128	2	vaccine	vaccine	NN
cord-290004-v3ruj5bq	128	3	constructs	construct	VBZ
cord-290004-v3ruj5bq	128	4	use	use	VBP
cord-290004-v3ruj5bq	128	5	viral	viral	JJ
cord-290004-v3ruj5bq	128	6	vectors	vector	NNS
cord-290004-v3ruj5bq	128	7	expressing	express	VBG
cord-290004-v3ruj5bq	128	8	M1	M1	NNP
cord-290004-v3ruj5bq	128	9	and	and	CC
cord-290004-v3ruj5bq	128	10	NP	NP	NNP
cord-290004-v3ruj5bq	128	11	[	[	-LRB-
cord-290004-v3ruj5bq	128	12	54	54	CD
cord-290004-v3ruj5bq	128	13	,	,	,
cord-290004-v3ruj5bq	128	14	81	81	CD
cord-290004-v3ruj5bq	128	15	]	]	-RRB-
cord-290004-v3ruj5bq	128	16	.	.	.
cord-290004-v3ruj5bq	129	1	These	these	DT
cord-290004-v3ruj5bq	129	2	have	have	VBP
cord-290004-v3ruj5bq	129	3	been	be	VBN
cord-290004-v3ruj5bq	129	4	shown	show	VBN
cord-290004-v3ruj5bq	129	5	to	to	TO
cord-290004-v3ruj5bq	129	6	induce	induce	VB
cord-290004-v3ruj5bq	129	7	CD4	CD4	NNP
cord-290004-v3ruj5bq	129	8	+	+	CC
cord-290004-v3ruj5bq	129	9	and	and	CC
cord-290004-v3ruj5bq	129	10	CD8	CD8	NNP
cord-290004-v3ruj5bq	129	11	+	+	CC
cord-290004-v3ruj5bq	129	12	T	T	NNP
cord-290004-v3ruj5bq	129	13	cells	cell	NNS
cord-290004-v3ruj5bq	129	14	in	in	IN
cord-290004-v3ruj5bq	129	15	clinical	clinical	JJ
cord-290004-v3ruj5bq	129	16	trials	trial	NNS
cord-290004-v3ruj5bq	129	17	.	.	.
cord-290004-v3ruj5bq	130	1	Selecting	select	VBG
cord-290004-v3ruj5bq	130	2	the	the	DT
cord-290004-v3ruj5bq	130	3	best	good	JJS
cord-290004-v3ruj5bq	130	4	approach	approach	NN
cord-290004-v3ruj5bq	130	5	for	for	IN
cord-290004-v3ruj5bq	130	6	inducing	induce	VBG
cord-290004-v3ruj5bq	130	7	T	t	NN
cord-290004-v3ruj5bq	130	8	-	-	HYPH
cord-290004-v3ruj5bq	130	9	cell	cell	NN
cord-290004-v3ruj5bq	130	10	-	-	HYPH
cord-290004-v3ruj5bq	130	11	mediated	mediate	VBN
cord-290004-v3ruj5bq	130	12	immunity	immunity	NN
cord-290004-v3ruj5bq	130	13	can	can	MD
cord-290004-v3ruj5bq	130	14	be	be	VB
cord-290004-v3ruj5bq	130	15	challenging	challenge	VBG
cord-290004-v3ruj5bq	130	16	due	due	IN
cord-290004-v3ruj5bq	130	17	to	to	IN
cord-290004-v3ruj5bq	130	18	the	the	DT
cord-290004-v3ruj5bq	130	19	diverse	diverse	JJ
cord-290004-v3ruj5bq	130	20	CD4	CD4	NNP
cord-290004-v3ruj5bq	130	21	T	T	NNP
cord-290004-v3ruj5bq	130	22	-	-	HYPH
cord-290004-v3ruj5bq	130	23	cell	cell	NN
cord-290004-v3ruj5bq	130	24	repertoire	repertoire	NN
cord-290004-v3ruj5bq	130	25	in	in	IN
cord-290004-v3ruj5bq	130	26	humans	human	NNS
cord-290004-v3ruj5bq	130	27	with	with	IN
cord-290004-v3ruj5bq	130	28	different	different	JJ
cord-290004-v3ruj5bq	130	29	degrees	degree	NNS
cord-290004-v3ruj5bq	130	30	of	of	IN
cord-290004-v3ruj5bq	130	31	pre	pre	JJ
cord-290004-v3ruj5bq	130	32	-	-	JJ
cord-290004-v3ruj5bq	130	33	existing	existing	JJ
cord-290004-v3ruj5bq	130	34	immunity	immunity	NN
cord-290004-v3ruj5bq	130	35	.	.	.
cord-290004-v3ruj5bq	131	1	However	however	RB
cord-290004-v3ruj5bq	131	2	,	,	,
cord-290004-v3ruj5bq	131	3	with	with	IN
cord-290004-v3ruj5bq	131	4	increasing	increase	VBG
cord-290004-v3ruj5bq	131	5	insights	insight	NNS
cord-290004-v3ruj5bq	131	6	into	into	IN
cord-290004-v3ruj5bq	131	7	the	the	DT
cord-290004-v3ruj5bq	131	8	quantity	quantity	NN
cord-290004-v3ruj5bq	131	9	,	,	,
cord-290004-v3ruj5bq	131	10	functionality	functionality	NN
cord-290004-v3ruj5bq	131	11	,	,	,
cord-290004-v3ruj5bq	131	12	and	and	CC
cord-290004-v3ruj5bq	131	13	specificity	specificity	NN
cord-290004-v3ruj5bq	131	14	of	of	IN
cord-290004-v3ruj5bq	131	15	CD4	CD4	NNP
cord-290004-v3ruj5bq	131	16	T	T	NNP
cord-290004-v3ruj5bq	131	17	-	-	HYPH
cord-290004-v3ruj5bq	131	18	cell	cell	NN
cord-290004-v3ruj5bq	131	19	subsets	subset	NNS
cord-290004-v3ruj5bq	131	20	,	,	,
cord-290004-v3ruj5bq	131	21	there	there	EX
cord-290004-v3ruj5bq	131	22	is	be	VBZ
cord-290004-v3ruj5bq	131	23	hope	hope	NN
cord-290004-v3ruj5bq	131	24	that	that	IN
cord-290004-v3ruj5bq	131	25	new	new	JJ
cord-290004-v3ruj5bq	131	26	correlates	correlate	NNS
cord-290004-v3ruj5bq	131	27	of	of	IN
cord-290004-v3ruj5bq	131	28	protection	protection	NN
cord-290004-v3ruj5bq	131	29	can	can	MD
cord-290004-v3ruj5bq	131	30	be	be	VB
cord-290004-v3ruj5bq	131	31	established	establish	VBN
cord-290004-v3ruj5bq	131	32	in	in	IN
cord-290004-v3ruj5bq	131	33	the	the	DT
cord-290004-v3ruj5bq	131	34	near	near	JJ
cord-290004-v3ruj5bq	131	35	future	future	NN
cord-290004-v3ruj5bq	131	36	,	,	,
cord-290004-v3ruj5bq	131	37	which	which	WDT
cord-290004-v3ruj5bq	131	38	would	would	MD
cord-290004-v3ruj5bq	131	39	help	help	VB
cord-290004-v3ruj5bq	131	40	in	in	IN
cord-290004-v3ruj5bq	131	41	selecting	select	VBG
cord-290004-v3ruj5bq	131	42	the	the	DT
cord-290004-v3ruj5bq	131	43	best	good	JJS
cord-290004-v3ruj5bq	131	44	vaccine	vaccine	NN
cord-290004-v3ruj5bq	131	45	candidates	candidate	NNS
cord-290004-v3ruj5bq	131	46	for	for	IN
cord-290004-v3ruj5bq	131	47	clinical	clinical	JJ
cord-290004-v3ruj5bq	131	48	trials	trial	NNS
cord-290004-v3ruj5bq	131	49	[	[	-LRB-
cord-290004-v3ruj5bq	131	50	29	29	CD
cord-290004-v3ruj5bq	131	51	,	,	,
cord-290004-v3ruj5bq	131	52	82	82	CD
cord-290004-v3ruj5bq	131	53	,	,	,
cord-290004-v3ruj5bq	131	54	83	83	CD
cord-290004-v3ruj5bq	131	55	]	]	-RRB-
cord-290004-v3ruj5bq	131	56	.	.	.
cord-290004-v3ruj5bq	132	1	Some	some	DT
cord-290004-v3ruj5bq	132	2	studies	study	NNS
cord-290004-v3ruj5bq	132	3	evaluating	evaluate	VBG
cord-290004-v3ruj5bq	132	4	the	the	DT
cord-290004-v3ruj5bq	132	5	T	t	NN
cord-290004-v3ruj5bq	132	6	-	-	HYPH
cord-290004-v3ruj5bq	132	7	cell	cell	NN
cord-290004-v3ruj5bq	132	8	response	response	NN
cord-290004-v3ruj5bq	132	9	in	in	IN
cord-290004-v3ruj5bq	132	10	various	various	JJ
cord-290004-v3ruj5bq	132	11	infection	infection	NN
cord-290004-v3ruj5bq	132	12	models	model	NNS
cord-290004-v3ruj5bq	132	13	have	have	VBP
cord-290004-v3ruj5bq	132	14	reported	report	VBN
cord-290004-v3ruj5bq	132	15	immunopathology	immunopathology	NN
cord-290004-v3ruj5bq	132	16	with	with	IN
cord-290004-v3ruj5bq	132	17	excessively	excessively	RB
cord-290004-v3ruj5bq	132	18	large	large	JJ
cord-290004-v3ruj5bq	132	19	CD8	CD8	NNP
cord-290004-v3ruj5bq	132	20	T	t	NN
cord-290004-v3ruj5bq	132	21	-	-	HYPH
cord-290004-v3ruj5bq	132	22	cell	cell	NN
cord-290004-v3ruj5bq	132	23	responses	response	NNS
cord-290004-v3ruj5bq	132	24	[	[	-LRB-
cord-290004-v3ruj5bq	132	25	84	84	CD
cord-290004-v3ruj5bq	132	26	,	,	,
cord-290004-v3ruj5bq	132	27	85	85	CD
cord-290004-v3ruj5bq	132	28	]	]	-RRB-
cord-290004-v3ruj5bq	132	29	.	.	.
cord-290004-v3ruj5bq	133	1	Other	other	JJ
cord-290004-v3ruj5bq	133	2	studies	study	NNS
cord-290004-v3ruj5bq	133	3	have	have	VBP
cord-290004-v3ruj5bq	133	4	reported	report	VBN
cord-290004-v3ruj5bq	133	5	a	a	DT
cord-290004-v3ruj5bq	133	6	narrowing	narrowing	NN
cord-290004-v3ruj5bq	133	7	of	of	IN
cord-290004-v3ruj5bq	133	8	T	t	NN
cord-290004-v3ruj5bq	133	9	-	-	HYPH
cord-290004-v3ruj5bq	133	10	cell	cell	NN
cord-290004-v3ruj5bq	133	11	receptors	receptor	NNS
cord-290004-v3ruj5bq	133	12	during	during	IN
cord-290004-v3ruj5bq	133	13	heterosubtypic	heterosubtypic	JJ
cord-290004-v3ruj5bq	133	14	challenges	challenge	NNS
cord-290004-v3ruj5bq	133	15	[	[	-LRB-
cord-290004-v3ruj5bq	133	16	86	86	CD
cord-290004-v3ruj5bq	133	17	]	]	-RRB-
cord-290004-v3ruj5bq	133	18	.	.	.
cord-290004-v3ruj5bq	134	1	Additional	additional	JJ
cord-290004-v3ruj5bq	134	2	studies	study	NNS
cord-290004-v3ruj5bq	134	3	that	that	WDT
cord-290004-v3ruj5bq	134	4	reflect	reflect	VBP
cord-290004-v3ruj5bq	134	5	pathogen	pathogen	NN
cord-290004-v3ruj5bq	134	6	encounters	encounter	NNS
cord-290004-v3ruj5bq	134	7	in	in	IN
cord-290004-v3ruj5bq	134	8	humans	human	NNS
cord-290004-v3ruj5bq	134	9	are	be	VBP
cord-290004-v3ruj5bq	134	10	needed	need	VBN
cord-290004-v3ruj5bq	134	11	in	in	IN
cord-290004-v3ruj5bq	134	12	order	order	NN
cord-290004-v3ruj5bq	134	13	to	to	TO
cord-290004-v3ruj5bq	134	14	select	select	VB
cord-290004-v3ruj5bq	134	15	the	the	DT
cord-290004-v3ruj5bq	134	16	best	good	JJS
cord-290004-v3ruj5bq	134	17	candidates	candidate	NNS
cord-290004-v3ruj5bq	134	18	for	for	IN
cord-290004-v3ruj5bq	134	19	next	next	JJ
cord-290004-v3ruj5bq	134	20	-	-	HYPH
cord-290004-v3ruj5bq	134	21	generation	generation	NN
cord-290004-v3ruj5bq	134	22	T	t	NN
cord-290004-v3ruj5bq	134	23	-	-	HYPH
cord-290004-v3ruj5bq	134	24	cell	cell	NN
cord-290004-v3ruj5bq	134	25	-	-	HYPH
cord-290004-v3ruj5bq	134	26	based	base	VBN
cord-290004-v3ruj5bq	134	27	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	134	28	[	[	-LRB-
cord-290004-v3ruj5bq	134	29	87	87	CD
cord-290004-v3ruj5bq	134	30	]	]	-RRB-
cord-290004-v3ruj5bq	134	31	.	.	.
cord-290004-v3ruj5bq	135	1	There	there	EX
cord-290004-v3ruj5bq	135	2	has	have	VBZ
cord-290004-v3ruj5bq	135	3	been	be	VBN
cord-290004-v3ruj5bq	135	4	significant	significant	JJ
cord-290004-v3ruj5bq	135	5	progress	progress	NN
cord-290004-v3ruj5bq	135	6	in	in	IN
cord-290004-v3ruj5bq	135	7	the	the	DT
cord-290004-v3ruj5bq	135	8	development	development	NN
cord-290004-v3ruj5bq	135	9	of	of	IN
cord-290004-v3ruj5bq	135	10	novel	novel	JJ
cord-290004-v3ruj5bq	135	11	approaches	approach	NNS
cord-290004-v3ruj5bq	135	12	for	for	IN
cord-290004-v3ruj5bq	135	13	universal	universal	JJ
cord-290004-v3ruj5bq	135	14	influenza	influenza	NN
cord-290004-v3ruj5bq	135	15	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	135	16	.	.	.
cord-290004-v3ruj5bq	136	1	However	however	RB
cord-290004-v3ruj5bq	136	2	,	,	,
cord-290004-v3ruj5bq	136	3	additional	additional	JJ
cord-290004-v3ruj5bq	136	4	efforts	effort	NNS
cord-290004-v3ruj5bq	136	5	are	be	VBP
cord-290004-v3ruj5bq	136	6	needed	need	VBN
cord-290004-v3ruj5bq	136	7	in	in	IN
cord-290004-v3ruj5bq	136	8	order	order	NN
cord-290004-v3ruj5bq	136	9	to	to	TO
cord-290004-v3ruj5bq	136	10	translate	translate	VB
cord-290004-v3ruj5bq	136	11	more	more	JJR
cord-290004-v3ruj5bq	136	12	of	of	IN
cord-290004-v3ruj5bq	136	13	these	these	DT
cord-290004-v3ruj5bq	136	14	novel	novel	JJ
cord-290004-v3ruj5bq	136	15	approaches	approach	NNS
cord-290004-v3ruj5bq	136	16	into	into	IN
cord-290004-v3ruj5bq	136	17	products	product	NNS
cord-290004-v3ruj5bq	136	18	ready	ready	JJ
cord-290004-v3ruj5bq	136	19	for	for	IN
cord-290004-v3ruj5bq	136	20	late	late	JJ
cord-290004-v3ruj5bq	136	21	-	-	HYPH
cord-290004-v3ruj5bq	136	22	stage	stage	NN
cord-290004-v3ruj5bq	136	23	clinical	clinical	JJ
cord-290004-v3ruj5bq	136	24	trials	trial	NNS
cord-290004-v3ruj5bq	136	25	.	.	.
cord-290004-v3ruj5bq	137	1	Selecting	select	VBG
cord-290004-v3ruj5bq	137	2	the	the	DT
cord-290004-v3ruj5bq	137	3	best	good	JJS
cord-290004-v3ruj5bq	137	4	candidates	candidate	NNS
cord-290004-v3ruj5bq	137	5	for	for	IN
cord-290004-v3ruj5bq	137	6	clinical	clinical	JJ
cord-290004-v3ruj5bq	137	7	trials	trial	NNS
cord-290004-v3ruj5bq	137	8	is	be	VBZ
cord-290004-v3ruj5bq	137	9	a	a	DT
cord-290004-v3ruj5bq	137	10	challenging	challenging	JJ
cord-290004-v3ruj5bq	137	11	process	process	NN
cord-290004-v3ruj5bq	137	12	for	for	IN
cord-290004-v3ruj5bq	137	13	several	several	JJ
cord-290004-v3ruj5bq	137	14	reasons	reason	NNS
cord-290004-v3ruj5bq	137	15	:	:	:
cord-290004-v3ruj5bq	137	16	(	(	-LRB-
cord-290004-v3ruj5bq	137	17	1	1	LS
cord-290004-v3ruj5bq	137	18	)	)	-RRB-
cord-290004-v3ruj5bq	137	19	There	there	EX
cord-290004-v3ruj5bq	137	20	is	be	VBZ
cord-290004-v3ruj5bq	137	21	no	no	DT
cord-290004-v3ruj5bq	137	22	uniform	uniform	JJ
cord-290004-v3ruj5bq	137	23	evaluation	evaluation	NN
cord-290004-v3ruj5bq	137	24	of	of	IN
cord-290004-v3ruj5bq	137	25	novel	novel	JJ
cord-290004-v3ruj5bq	137	26	influenza	influenza	NN
cord-290004-v3ruj5bq	137	27	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	137	28	in	in	IN
cord-290004-v3ruj5bq	137	29	preclinical	preclinical	JJ
cord-290004-v3ruj5bq	137	30	trials	trial	NNS
cord-290004-v3ruj5bq	137	31	.	.	.
cord-290004-v3ruj5bq	138	1	This	this	DT
cord-290004-v3ruj5bq	138	2	is	be	VBZ
cord-290004-v3ruj5bq	138	3	partly	partly	RB
cord-290004-v3ruj5bq	138	4	due	due	JJ
cord-290004-v3ruj5bq	138	5	to	to	IN
cord-290004-v3ruj5bq	138	6	the	the	DT
cord-290004-v3ruj5bq	138	7	variety	variety	NN
cord-290004-v3ruj5bq	138	8	of	of	IN
cord-290004-v3ruj5bq	138	9	vaccine	vaccine	NN
cord-290004-v3ruj5bq	138	10	platforms	platform	NNS
cord-290004-v3ruj5bq	138	11	and	and	CC
cord-290004-v3ruj5bq	138	12	targets	target	NNS
cord-290004-v3ruj5bq	138	13	.	.	.
cord-290004-v3ruj5bq	139	1	In	in	IN
cord-290004-v3ruj5bq	139	2	addition	addition	NN
cord-290004-v3ruj5bq	139	3	,	,	,
cord-290004-v3ruj5bq	139	4	there	there	EX
cord-290004-v3ruj5bq	139	5	is	be	VBZ
cord-290004-v3ruj5bq	139	6	no	no	DT
cord-290004-v3ruj5bq	139	7	consensus	consensus	NN
cord-290004-v3ruj5bq	139	8	on	on	IN
cord-290004-v3ruj5bq	139	9	which	which	WDT
cord-290004-v3ruj5bq	139	10	animal	animal	NN
cord-290004-v3ruj5bq	139	11	model	model	NN
cord-290004-v3ruj5bq	139	12	is	be	VBZ
cord-290004-v3ruj5bq	139	13	best	well	RBS
cord-290004-v3ruj5bq	139	14	suited	suit	VBN
cord-290004-v3ruj5bq	139	15	to	to	TO
cord-290004-v3ruj5bq	139	16	accurately	accurately	RB
cord-290004-v3ruj5bq	139	17	reflect	reflect	VB
cord-290004-v3ruj5bq	139	18	human	human	JJ
cord-290004-v3ruj5bq	139	19	infection	infection	NN
cord-290004-v3ruj5bq	139	20	[	[	-LRB-
cord-290004-v3ruj5bq	139	21	3	3	CD
cord-290004-v3ruj5bq	139	22	,	,	,
cord-290004-v3ruj5bq	139	23	88	88	CD
cord-290004-v3ruj5bq	139	24	]	]	-RRB-
cord-290004-v3ruj5bq	139	25	.	.	.
cord-290004-v3ruj5bq	140	1	This	this	DT
cord-290004-v3ruj5bq	140	2	is	be	VBZ
cord-290004-v3ruj5bq	140	3	partly	partly	RB
cord-290004-v3ruj5bq	140	4	due	due	JJ
cord-290004-v3ruj5bq	140	5	to	to	IN
cord-290004-v3ruj5bq	140	6	the	the	DT
cord-290004-v3ruj5bq	140	7	existence	existence	NN
cord-290004-v3ruj5bq	140	8	of	of	IN
cord-290004-v3ruj5bq	140	9	pre	pre	JJ
cord-290004-v3ruj5bq	140	10	-	-	JJ
cord-290004-v3ruj5bq	140	11	existing	existing	JJ
cord-290004-v3ruj5bq	140	12	immunity	immunity	NN
cord-290004-v3ruj5bq	140	13	in	in	IN
cord-290004-v3ruj5bq	140	14	humans	human	NNS
cord-290004-v3ruj5bq	140	15	,	,	,
cord-290004-v3ruj5bq	140	16	which	which	WDT
cord-290004-v3ruj5bq	140	17	is	be	VBZ
cord-290004-v3ruj5bq	140	18	difficult	difficult	JJ
cord-290004-v3ruj5bq	140	19	to	to	TO
cord-290004-v3ruj5bq	140	20	translate	translate	VB
cord-290004-v3ruj5bq	140	21	into	into	IN
cord-290004-v3ruj5bq	140	22	animal	animal	NN
cord-290004-v3ruj5bq	140	23	models	model	NNS
cord-290004-v3ruj5bq	140	24	.	.	.
cord-290004-v3ruj5bq	141	1	Other	other	JJ
cord-290004-v3ruj5bq	141	2	host	host	NN
cord-290004-v3ruj5bq	141	3	factors	factor	NNS
cord-290004-v3ruj5bq	141	4	to	to	TO
cord-290004-v3ruj5bq	141	5	be	be	VB
cord-290004-v3ruj5bq	141	6	considered	consider	VBN
cord-290004-v3ruj5bq	141	7	include	include	VBP
cord-290004-v3ruj5bq	141	8	age	age	NN
cord-290004-v3ruj5bq	141	9	,	,	,
cord-290004-v3ruj5bq	141	10	gender	gender	NN
cord-290004-v3ruj5bq	141	11	,	,	,
cord-290004-v3ruj5bq	141	12	and	and	CC
cord-290004-v3ruj5bq	141	13	chronic	chronic	JJ
cord-290004-v3ruj5bq	141	14	diseases	disease	NNS
cord-290004-v3ruj5bq	141	15	,	,	,
cord-290004-v3ruj5bq	141	16	which	which	WDT
cord-290004-v3ruj5bq	141	17	could	could	MD
cord-290004-v3ruj5bq	141	18	affect	affect	VB
cord-290004-v3ruj5bq	141	19	vaccine	vaccine	NN
cord-290004-v3ruj5bq	141	20	efficacy	efficacy	NN
cord-290004-v3ruj5bq	141	21	.	.	.
cord-290004-v3ruj5bq	142	1	(	(	-LRB-
cord-290004-v3ruj5bq	142	2	2	2	LS
cord-290004-v3ruj5bq	142	3	)	)	-RRB-
cord-290004-v3ruj5bq	142	4	There	there	EX
cord-290004-v3ruj5bq	142	5	are	be	VBP
cord-290004-v3ruj5bq	142	6	no	no	DT
cord-290004-v3ruj5bq	142	7	established	establish	VBN
cord-290004-v3ruj5bq	142	8	correlates	correlate	NNS
cord-290004-v3ruj5bq	142	9	of	of	IN
cord-290004-v3ruj5bq	142	10	protection	protection	NN
cord-290004-v3ruj5bq	142	11	for	for	IN
cord-290004-v3ruj5bq	142	12	broadly	broadly	RB
cord-290004-v3ruj5bq	142	13	cross	cross	JJ
cord-290004-v3ruj5bq	142	14	-	-	JJ
cord-290004-v3ruj5bq	142	15	reactive	reactive	JJ
cord-290004-v3ruj5bq	142	16	immune	immune	JJ
cord-290004-v3ruj5bq	142	17	responses	response	NNS
cord-290004-v3ruj5bq	142	18	to	to	IN
cord-290004-v3ruj5bq	142	19	influenza	influenza	NN
cord-290004-v3ruj5bq	142	20	.	.	.
cord-290004-v3ruj5bq	143	1	Assays	assay	NNS
cord-290004-v3ruj5bq	143	2	measuring	measure	VBG
cord-290004-v3ruj5bq	143	3	non	non	JJ
cord-290004-v3ruj5bq	143	4	-	-	JJ
cord-290004-v3ruj5bq	143	5	HA	ha	NN
cord-290004-v3ruj5bq	143	6	-	-	HYPH
cord-290004-v3ruj5bq	143	7	head	head	NN
cord-290004-v3ruj5bq	143	8	immune	immune	JJ
cord-290004-v3ruj5bq	143	9	responses	response	NNS
cord-290004-v3ruj5bq	143	10	,	,	,
cord-290004-v3ruj5bq	143	11	such	such	JJ
cord-290004-v3ruj5bq	143	12	as	as	IN
cord-290004-v3ruj5bq	143	13	HA	HA	NNP
cord-290004-v3ruj5bq	143	14	stalk	stalk	NN
cord-290004-v3ruj5bq	143	15	antibodies	antibody	NNS
cord-290004-v3ruj5bq	143	16	,	,	,
cord-290004-v3ruj5bq	143	17	NA	NA	NNP
cord-290004-v3ruj5bq	143	18	antibodies	antibody	NNS
cord-290004-v3ruj5bq	143	19	,	,	,
cord-290004-v3ruj5bq	143	20	and	and	CC
cord-290004-v3ruj5bq	143	21	cellular	cellular	JJ
cord-290004-v3ruj5bq	143	22	immunity	immunity	NN
cord-290004-v3ruj5bq	143	23	,	,	,
cord-290004-v3ruj5bq	143	24	are	be	VBP
cord-290004-v3ruj5bq	143	25	inadequately	inadequately	RB
cord-290004-v3ruj5bq	143	26	standardized	standardize	VBN
cord-290004-v3ruj5bq	143	27	.	.	.
cord-290004-v3ruj5bq	144	1	Optimization	optimization	NN
cord-290004-v3ruj5bq	144	2	and	and	CC
cord-290004-v3ruj5bq	144	3	standardization	standardization	NN
cord-290004-v3ruj5bq	144	4	of	of	IN
cord-290004-v3ruj5bq	144	5	such	such	JJ
cord-290004-v3ruj5bq	144	6	assays	assay	NNS
cord-290004-v3ruj5bq	144	7	are	be	VBP
cord-290004-v3ruj5bq	144	8	needed	need	VBN
cord-290004-v3ruj5bq	144	9	in	in	IN
cord-290004-v3ruj5bq	144	10	order	order	NN
cord-290004-v3ruj5bq	144	11	to	to	TO
cord-290004-v3ruj5bq	144	12	assess	assess	VB
cord-290004-v3ruj5bq	144	13	the	the	DT
cord-290004-v3ruj5bq	144	14	protective	protective	JJ
cord-290004-v3ruj5bq	144	15	immunity	immunity	NN
cord-290004-v3ruj5bq	144	16	contributed	contribute	VBN
cord-290004-v3ruj5bq	144	17	by	by	IN
cord-290004-v3ruj5bq	144	18	broadly	broadly	RB
cord-290004-v3ruj5bq	144	19	reactive	reactive	JJ
cord-290004-v3ruj5bq	144	20	or	or	CC
cord-290004-v3ruj5bq	144	21	universal	universal	JJ
cord-290004-v3ruj5bq	144	22	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	144	23	.	.	.
cord-290004-v3ruj5bq	145	1	(	(	-LRB-
cord-290004-v3ruj5bq	145	2	3	3	LS
cord-290004-v3ruj5bq	145	3	)	)	-RRB-
cord-290004-v3ruj5bq	146	1	The	the	DT
cord-290004-v3ruj5bq	146	2	funding	funding	NN
cord-290004-v3ruj5bq	146	3	for	for	IN
cord-290004-v3ruj5bq	146	4	universal	universal	JJ
cord-290004-v3ruj5bq	146	5	vaccine	vaccine	NN
cord-290004-v3ruj5bq	146	6	development	development	NN
cord-290004-v3ruj5bq	146	7	is	be	VBZ
cord-290004-v3ruj5bq	146	8	limited	limit	VBN
cord-290004-v3ruj5bq	146	9	.	.	.
cord-290004-v3ruj5bq	147	1	This	this	DT
cord-290004-v3ruj5bq	147	2	leads	lead	VBZ
cord-290004-v3ruj5bq	147	3	to	to	IN
cord-290004-v3ruj5bq	147	4	down	down	RB
cord-290004-v3ruj5bq	147	5	selection	selection	NN
cord-290004-v3ruj5bq	147	6	of	of	IN
cord-290004-v3ruj5bq	147	7	promising	promising	JJ
cord-290004-v3ruj5bq	147	8	candidates	candidate	NNS
cord-290004-v3ruj5bq	147	9	before	before	IN
cord-290004-v3ruj5bq	147	10	they	-PRON-	PRP
cord-290004-v3ruj5bq	147	11	advance	advance	VBP
cord-290004-v3ruj5bq	147	12	to	to	IN
cord-290004-v3ruj5bq	147	13	clinical	clinical	JJ
cord-290004-v3ruj5bq	147	14	trials	trial	NNS
cord-290004-v3ruj5bq	147	15	.	.	.
cord-290004-v3ruj5bq	148	1	Regulatory	regulatory	JJ
cord-290004-v3ruj5bq	148	2	initiatives	initiative	NNS
cord-290004-v3ruj5bq	148	3	are	be	VBP
cord-290004-v3ruj5bq	148	4	needed	need	VBN
cord-290004-v3ruj5bq	148	5	to	to	TO
cord-290004-v3ruj5bq	148	6	enhance	enhance	VB
cord-290004-v3ruj5bq	148	7	advocacy	advocacy	NN
cord-290004-v3ruj5bq	148	8	for	for	IN
cord-290004-v3ruj5bq	148	9	moving	move	VBG
cord-290004-v3ruj5bq	148	10	from	from	IN
cord-290004-v3ruj5bq	148	11	an	an	DT
cord-290004-v3ruj5bq	148	12	annually	annually	RB
cord-290004-v3ruj5bq	148	13	reformulated	reformulate	VBN
cord-290004-v3ruj5bq	148	14	vaccine	vaccine	NN
cord-290004-v3ruj5bq	148	15	to	to	IN
cord-290004-v3ruj5bq	148	16	a	a	DT
cord-290004-v3ruj5bq	148	17	universal	universal	JJ
cord-290004-v3ruj5bq	148	18	vaccine	vaccine	NN
cord-290004-v3ruj5bq	148	19	,	,	,
cord-290004-v3ruj5bq	148	20	despite	despite	IN
cord-290004-v3ruj5bq	148	21	the	the	DT
cord-290004-v3ruj5bq	148	22	financial	financial	JJ
cord-290004-v3ruj5bq	148	23	risks	risk	NNS
cord-290004-v3ruj5bq	148	24	and	and	CC
cord-290004-v3ruj5bq	148	25	inadequate	inadequate	JJ
cord-290004-v3ruj5bq	148	26	incentives	incentive	NNS
cord-290004-v3ruj5bq	148	27	[	[	-LRB-
cord-290004-v3ruj5bq	148	28	6	6	CD
cord-290004-v3ruj5bq	148	29	]	]	-RRB-
cord-290004-v3ruj5bq	148	30	.	.	.
cord-290004-v3ruj5bq	149	1	As	as	IN
cord-290004-v3ruj5bq	149	2	the	the	DT
cord-290004-v3ruj5bq	149	3	search	search	NN
cord-290004-v3ruj5bq	149	4	for	for	IN
cord-290004-v3ruj5bq	149	5	an	an	DT
cord-290004-v3ruj5bq	149	6	appropriate	appropriate	JJ
cord-290004-v3ruj5bq	149	7	SARS	SARS	NNP
cord-290004-v3ruj5bq	149	8	-	-	HYPH
cord-290004-v3ruj5bq	149	9	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	149	10	vaccine	vaccine	NN
cord-290004-v3ruj5bq	149	11	continues	continue	VBZ
cord-290004-v3ruj5bq	149	12	,	,	,
cord-290004-v3ruj5bq	149	13	comparisons	comparison	NNS
cord-290004-v3ruj5bq	149	14	can	can	MD
cord-290004-v3ruj5bq	149	15	be	be	VB
cord-290004-v3ruj5bq	149	16	drawn	draw	VBN
cord-290004-v3ruj5bq	149	17	to	to	IN
cord-290004-v3ruj5bq	149	18	influenza	influenza	VB
cord-290004-v3ruj5bq	149	19	vaccine	vaccine	NN
cord-290004-v3ruj5bq	149	20	development	development	NN
cord-290004-v3ruj5bq	149	21	.	.	.
cord-290004-v3ruj5bq	150	1	Some	some	DT
cord-290004-v3ruj5bq	150	2	of	of	IN
cord-290004-v3ruj5bq	150	3	the	the	DT
cord-290004-v3ruj5bq	150	4	next	next	JJ
cord-290004-v3ruj5bq	150	5	-	-	HYPH
cord-290004-v3ruj5bq	150	6	generation	generation	NN
cord-290004-v3ruj5bq	150	7	influenza	influenza	NN
cord-290004-v3ruj5bq	150	8	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	150	9	use	use	VBP
cord-290004-v3ruj5bq	150	10	vaccine	vaccine	NN
cord-290004-v3ruj5bq	150	11	platforms	platform	NNS
cord-290004-v3ruj5bq	150	12	similar	similar	JJ
cord-290004-v3ruj5bq	150	13	to	to	IN
cord-290004-v3ruj5bq	150	14	those	those	DT
cord-290004-v3ruj5bq	150	15	used	use	VBN
cord-290004-v3ruj5bq	150	16	by	by	IN
cord-290004-v3ruj5bq	150	17	the	the	DT
cord-290004-v3ruj5bq	150	18	SARS	SARS	NNP
cord-290004-v3ruj5bq	150	19	-	-	HYPH
cord-290004-v3ruj5bq	150	20	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	150	21	vaccine	vaccine	NN
cord-290004-v3ruj5bq	150	22	candidates	candidate	NNS
cord-290004-v3ruj5bq	150	23	[	[	-LRB-
cord-290004-v3ruj5bq	150	24	89	89	CD
cord-290004-v3ruj5bq	150	25	]	]	-RRB-
cord-290004-v3ruj5bq	150	26	.	.	.
cord-290004-v3ruj5bq	151	1	Given	give	VBN
cord-290004-v3ruj5bq	151	2	the	the	DT
cord-290004-v3ruj5bq	151	3	urgency	urgency	NN
cord-290004-v3ruj5bq	151	4	of	of	IN
cord-290004-v3ruj5bq	151	5	moving	move	VBG
cord-290004-v3ruj5bq	151	6	forward	forward	RB
cord-290004-v3ruj5bq	151	7	with	with	IN
cord-290004-v3ruj5bq	151	8	a	a	DT
cord-290004-v3ruj5bq	151	9	SARS	SARS	NNP
cord-290004-v3ruj5bq	151	10	-	-	HYPH
cord-290004-v3ruj5bq	151	11	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	151	12	vaccine	vaccine	NN
cord-290004-v3ruj5bq	151	13	,	,	,
cord-290004-v3ruj5bq	151	14	a	a	DT
cord-290004-v3ruj5bq	151	15	nucleic	nucleic	JJ
cord-290004-v3ruj5bq	151	16	-	-	HYPH
cord-290004-v3ruj5bq	151	17	acid	acid	NN
cord-290004-v3ruj5bq	151	18	-	-	HYPH
cord-290004-v3ruj5bq	151	19	based	base	VBN
cord-290004-v3ruj5bq	151	20	vaccine	vaccine	NN
cord-290004-v3ruj5bq	151	21	would	would	MD
cord-290004-v3ruj5bq	151	22	be	be	VB
cord-290004-v3ruj5bq	151	23	a	a	DT
cord-290004-v3ruj5bq	151	24	convenient	convenient	JJ
cord-290004-v3ruj5bq	151	25	approach	approach	NN
cord-290004-v3ruj5bq	151	26	in	in	IN
cord-290004-v3ruj5bq	151	27	order	order	NN
cord-290004-v3ruj5bq	151	28	to	to	TO
cord-290004-v3ruj5bq	151	29	facilitate	facilitate	VB
cord-290004-v3ruj5bq	151	30	rapid	rapid	JJ
cord-290004-v3ruj5bq	151	31	production	production	NN
cord-290004-v3ruj5bq	151	32	.	.	.
cord-290004-v3ruj5bq	152	1	Although	although	IN
cord-290004-v3ruj5bq	152	2	this	this	DT
cord-290004-v3ruj5bq	152	3	method	method	NN
cord-290004-v3ruj5bq	152	4	has	have	VBZ
cord-290004-v3ruj5bq	152	5	been	be	VBN
cord-290004-v3ruj5bq	152	6	tested	test	VBN
cord-290004-v3ruj5bq	152	7	for	for	IN
cord-290004-v3ruj5bq	152	8	several	several	JJ
cord-290004-v3ruj5bq	152	9	influenza	influenza	NN
cord-290004-v3ruj5bq	152	10	vaccine	vaccine	NN
cord-290004-v3ruj5bq	152	11	candidates	candidate	NNS
cord-290004-v3ruj5bq	152	12	,	,	,
cord-290004-v3ruj5bq	152	13	no	no	DT
cord-290004-v3ruj5bq	152	14	DNA	DNA	NNP
cord-290004-v3ruj5bq	152	15	or	or	CC
cord-290004-v3ruj5bq	152	16	RNA	RNA	NNP
cord-290004-v3ruj5bq	152	17	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	152	18	have	have	VBP
cord-290004-v3ruj5bq	152	19	yet	yet	RB
cord-290004-v3ruj5bq	152	20	been	be	VBN
cord-290004-v3ruj5bq	152	21	licensed	license	VBN
cord-290004-v3ruj5bq	152	22	for	for	IN
cord-290004-v3ruj5bq	152	23	humans	human	NNS
cord-290004-v3ruj5bq	152	24	.	.	.
cord-290004-v3ruj5bq	153	1	The	the	DT
cord-290004-v3ruj5bq	153	2	disadvantages	disadvantage	NNS
cord-290004-v3ruj5bq	153	3	of	of	IN
cord-290004-v3ruj5bq	153	4	such	such	JJ
cord-290004-v3ruj5bq	153	5	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	153	6	include	include	VBP
cord-290004-v3ruj5bq	153	7	limited	limit	VBN
cord-290004-v3ruj5bq	153	8	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	153	9	and	and	CC
cord-290004-v3ruj5bq	153	10	reports	report	NNS
cord-290004-v3ruj5bq	153	11	of	of	IN
cord-290004-v3ruj5bq	153	12	increased	increase	VBN
cord-290004-v3ruj5bq	153	13	reactogenicity	reactogenicity	NN
cord-290004-v3ruj5bq	153	14	.	.	.
cord-290004-v3ruj5bq	154	1	Another	another	DT
cord-290004-v3ruj5bq	154	2	option	option	NN
cord-290004-v3ruj5bq	154	3	is	be	VBZ
cord-290004-v3ruj5bq	154	4	the	the	DT
cord-290004-v3ruj5bq	154	5	use	use	NN
cord-290004-v3ruj5bq	154	6	of	of	IN
cord-290004-v3ruj5bq	154	7	viral	viral	JJ
cord-290004-v3ruj5bq	154	8	-	-	HYPH
cord-290004-v3ruj5bq	154	9	vector	vector	NN
cord-290004-v3ruj5bq	154	10	-	-	HYPH
cord-290004-v3ruj5bq	154	11	based	base	VBN
cord-290004-v3ruj5bq	154	12	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	154	13	,	,	,
cord-290004-v3ruj5bq	154	14	which	which	WDT
cord-290004-v3ruj5bq	154	15	have	have	VBP
cord-290004-v3ruj5bq	154	16	shown	show	VBN
cord-290004-v3ruj5bq	154	17	promising	promising	JJ
cord-290004-v3ruj5bq	154	18	results	result	NNS
cord-290004-v3ruj5bq	154	19	against	against	IN
cord-290004-v3ruj5bq	154	20	MERS	MERS	NNP
cord-290004-v3ruj5bq	154	21	-	-	HYPH
cord-290004-v3ruj5bq	154	22	CoV	CoV	NNP
cord-290004-v3ruj5bq	154	23	and	and	CC
cord-290004-v3ruj5bq	154	24	other	other	JJ
cord-290004-v3ruj5bq	154	25	emerging	emerge	VBG
cord-290004-v3ruj5bq	154	26	viruses	virus	NNS
cord-290004-v3ruj5bq	154	27	[	[	-LRB-
cord-290004-v3ruj5bq	154	28	90	90	CD
cord-290004-v3ruj5bq	154	29	]	]	-RRB-
cord-290004-v3ruj5bq	154	30	[	[	-LRB-
cord-290004-v3ruj5bq	154	31	91	91	CD
cord-290004-v3ruj5bq	154	32	]	]	-RRB-
cord-290004-v3ruj5bq	154	33	[	[	-LRB-
cord-290004-v3ruj5bq	154	34	92	92	CD
cord-290004-v3ruj5bq	154	35	]	]	-RRB-
cord-290004-v3ruj5bq	154	36	.	.	.
cord-290004-v3ruj5bq	155	1	Some	some	DT
cord-290004-v3ruj5bq	155	2	viral	viral	JJ
cord-290004-v3ruj5bq	155	3	-	-	HYPH
cord-290004-v3ruj5bq	155	4	vector	vector	NN
cord-290004-v3ruj5bq	155	5	-	-	HYPH
cord-290004-v3ruj5bq	155	6	based	base	VBN
cord-290004-v3ruj5bq	155	7	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	155	8	focusing	focus	VBG
cord-290004-v3ruj5bq	155	9	on	on	IN
cord-290004-v3ruj5bq	155	10	the	the	DT
cord-290004-v3ruj5bq	155	11	S	S	NNP
cord-290004-v3ruj5bq	155	12	protein	protein	NN
cord-290004-v3ruj5bq	155	13	of	of	IN
cord-290004-v3ruj5bq	155	14	the	the	DT
cord-290004-v3ruj5bq	155	15	SARS	SARS	NNP
cord-290004-v3ruj5bq	155	16	-	-	HYPH
cord-290004-v3ruj5bq	155	17	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	155	18	virus	virus	NN
cord-290004-v3ruj5bq	155	19	are	be	VBP
cord-290004-v3ruj5bq	155	20	in	in	IN
cord-290004-v3ruj5bq	155	21	the	the	DT
cord-290004-v3ruj5bq	155	22	preclinical	preclinical	JJ
cord-290004-v3ruj5bq	155	23	phase	phase	NN
cord-290004-v3ruj5bq	155	24	.	.	.
cord-290004-v3ruj5bq	156	1	However	however	RB
cord-290004-v3ruj5bq	156	2	,	,	,
cord-290004-v3ruj5bq	156	3	it	-PRON-	PRP
cord-290004-v3ruj5bq	156	4	might	may	MD
cord-290004-v3ruj5bq	156	5	be	be	VB
cord-290004-v3ruj5bq	156	6	years	year	NNS
cord-290004-v3ruj5bq	156	7	until	until	IN
cord-290004-v3ruj5bq	156	8	a	a	DT
cord-290004-v3ruj5bq	156	9	nucleic	nucleic	RB
cord-290004-v3ruj5bq	156	10	-	-	HYPH
cord-290004-v3ruj5bq	156	11	acidor	acidor	JJ
cord-290004-v3ruj5bq	156	12	viral	viral	JJ
cord-290004-v3ruj5bq	156	13	-	-	HYPH
cord-290004-v3ruj5bq	156	14	vector	vector	NN
cord-290004-v3ruj5bq	156	15	-	-	HYPH
cord-290004-v3ruj5bq	156	16	based	base	VBN
cord-290004-v3ruj5bq	156	17	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	156	18	are	be	VBP
cord-290004-v3ruj5bq	156	19	licensed	license	VBN
cord-290004-v3ruj5bq	156	20	for	for	IN
cord-290004-v3ruj5bq	156	21	human	human	JJ
cord-290004-v3ruj5bq	156	22	use	use	NN
cord-290004-v3ruj5bq	156	23	since	since	IN
cord-290004-v3ruj5bq	156	24	both	both	DT
cord-290004-v3ruj5bq	156	25	of	of	IN
cord-290004-v3ruj5bq	156	26	these	these	DT
cord-290004-v3ruj5bq	156	27	vaccine	vaccine	NN
cord-290004-v3ruj5bq	156	28	platforms	platform	NNS
cord-290004-v3ruj5bq	156	29	are	be	VBP
cord-290004-v3ruj5bq	156	30	novel	novel	JJ
cord-290004-v3ruj5bq	156	31	and	and	CC
cord-290004-v3ruj5bq	156	32	have	have	VBP
cord-290004-v3ruj5bq	156	33	not	not	RB
cord-290004-v3ruj5bq	156	34	been	be	VBN
cord-290004-v3ruj5bq	156	35	extensively	extensively	RB
cord-290004-v3ruj5bq	156	36	tested	test	VBN
cord-290004-v3ruj5bq	156	37	.	.	.
cord-290004-v3ruj5bq	157	1	Other	other	JJ
cord-290004-v3ruj5bq	157	2	SARS	SARS	NNP
cord-290004-v3ruj5bq	157	3	-	-	HYPH
cord-290004-v3ruj5bq	157	4	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	157	5	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	157	6	that	that	WDT
cord-290004-v3ruj5bq	157	7	are	be	VBP
cord-290004-v3ruj5bq	157	8	currently	currently	RB
cord-290004-v3ruj5bq	157	9	being	be	VBG
cord-290004-v3ruj5bq	157	10	tested	test	VBN
cord-290004-v3ruj5bq	157	11	include	include	VBP
cord-290004-v3ruj5bq	157	12	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	157	13	protein	protein	NN
cord-290004-v3ruj5bq	157	14	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	157	15	,	,	,
cord-290004-v3ruj5bq	157	16	live	live	RB
cord-290004-v3ruj5bq	157	17	-	-	HYPH
cord-290004-v3ruj5bq	157	18	attenuated	attenuate	VBN
cord-290004-v3ruj5bq	157	19	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	157	20	,	,	,
cord-290004-v3ruj5bq	157	21	and	and	CC
cord-290004-v3ruj5bq	157	22	inactivated	inactivate	VBN
cord-290004-v3ruj5bq	157	23	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	157	24	.	.	.
cord-290004-v3ruj5bq	158	1	All	all	DT
cord-290004-v3ruj5bq	158	2	of	of	IN
cord-290004-v3ruj5bq	158	3	these	these	DT
cord-290004-v3ruj5bq	158	4	platforms	platform	NNS
cord-290004-v3ruj5bq	158	5	can	can	MD
cord-290004-v3ruj5bq	158	6	be	be	VB
cord-290004-v3ruj5bq	158	7	found	find	VBN
cord-290004-v3ruj5bq	158	8	among	among	IN
cord-290004-v3ruj5bq	158	9	the	the	DT
cord-290004-v3ruj5bq	158	10	licensed	licensed	JJ
cord-290004-v3ruj5bq	158	11	influenza	influenza	NN
cord-290004-v3ruj5bq	158	12	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	158	13	,	,	,
cord-290004-v3ruj5bq	158	14	each	each	DT
cord-290004-v3ruj5bq	158	15	with	with	IN
cord-290004-v3ruj5bq	158	16	their	-PRON-	PRP$
cord-290004-v3ruj5bq	158	17	own	own	JJ
cord-290004-v3ruj5bq	158	18	advantages	advantage	NNS
cord-290004-v3ruj5bq	158	19	and	and	CC
cord-290004-v3ruj5bq	158	20	disadvantages	disadvantage	NNS
cord-290004-v3ruj5bq	158	21	.	.	.
cord-290004-v3ruj5bq	159	1	In	in	IN
cord-290004-v3ruj5bq	159	2	the	the	DT
cord-290004-v3ruj5bq	159	3	end	end	NN
cord-290004-v3ruj5bq	159	4	,	,	,
cord-290004-v3ruj5bq	159	5	a	a	DT
cord-290004-v3ruj5bq	159	6	SARS	SARS	NNP
cord-290004-v3ruj5bq	159	7	-	-	HYPH
cord-290004-v3ruj5bq	159	8	CoV-2	CoV-2	NNP
cord-290004-v3ruj5bq	159	9	vaccine	vaccine	NN
cord-290004-v3ruj5bq	159	10	or	or	CC
cord-290004-v3ruj5bq	159	11	a	a	DT
cord-290004-v3ruj5bq	159	12	universal	universal	JJ
cord-290004-v3ruj5bq	159	13	influenza	influenza	NN
cord-290004-v3ruj5bq	159	14	vaccine	vaccine	NN
cord-290004-v3ruj5bq	159	15	can	can	MD
cord-290004-v3ruj5bq	159	16	only	only	RB
cord-290004-v3ruj5bq	159	17	be	be	VB
cord-290004-v3ruj5bq	159	18	successful	successful	JJ
cord-290004-v3ruj5bq	159	19	if	if	IN
cord-290004-v3ruj5bq	159	20	implemented	implement	VBN
cord-290004-v3ruj5bq	159	21	effectively	effectively	RB
cord-290004-v3ruj5bq	159	22	[	[	-LRB-
cord-290004-v3ruj5bq	159	23	93	93	CD
cord-290004-v3ruj5bq	159	24	]	]	-RRB-
cord-290004-v3ruj5bq	159	25	.	.	.
cord-290004-v3ruj5bq	160	1	Efforts	effort	NNS
cord-290004-v3ruj5bq	160	2	are	be	VBP
cord-290004-v3ruj5bq	160	3	needed	need	VBN
cord-290004-v3ruj5bq	160	4	to	to	TO
cord-290004-v3ruj5bq	160	5	improve	improve	VB
cord-290004-v3ruj5bq	160	6	vaccine	vaccine	NN
cord-290004-v3ruj5bq	160	7	uptake	uptake	NN
cord-290004-v3ruj5bq	160	8	by	by	IN
cord-290004-v3ruj5bq	160	9	restoring	restore	VBG
cord-290004-v3ruj5bq	160	10	widespread	widespread	JJ
cord-290004-v3ruj5bq	160	11	public	public	JJ
cord-290004-v3ruj5bq	160	12	confidence	confidence	NN
cord-290004-v3ruj5bq	160	13	in	in	IN
cord-290004-v3ruj5bq	160	14	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	160	15	.	.	.
cord-290004-v3ruj5bq	161	1	This	this	DT
cord-290004-v3ruj5bq	161	2	is	be	VBZ
cord-290004-v3ruj5bq	161	3	especially	especially	RB
cord-290004-v3ruj5bq	161	4	important	important	JJ
cord-290004-v3ruj5bq	161	5	in	in	IN
cord-290004-v3ruj5bq	161	6	a	a	DT
cord-290004-v3ruj5bq	161	7	pandemic	pandemic	NN
cord-290004-v3ruj5bq	161	8	setting	setting	NN
cord-290004-v3ruj5bq	161	9	.	.	.
cord-290004-v3ruj5bq	162	1	In	in	IN
cord-290004-v3ruj5bq	162	2	addition	addition	NN
cord-290004-v3ruj5bq	162	3	,	,	,
cord-290004-v3ruj5bq	162	4	as	as	IN
cord-290004-v3ruj5bq	162	5	the	the	DT
cord-290004-v3ruj5bq	162	6	2009	2009	CD
cord-290004-v3ruj5bq	162	7	influenza	influenza	NN
cord-290004-v3ruj5bq	162	8	A	A	NNP
cord-290004-v3ruj5bq	162	9	/	/	SYM
cord-290004-v3ruj5bq	162	10	H1N1	H1N1	NNP
cord-290004-v3ruj5bq	162	11	pandemic	pandemic	NN
cord-290004-v3ruj5bq	162	12	demonstrated	demonstrate	VBD
cord-290004-v3ruj5bq	162	13	,	,	,
cord-290004-v3ruj5bq	162	14	there	there	EX
cord-290004-v3ruj5bq	162	15	will	will	MD
cord-290004-v3ruj5bq	162	16	likely	likely	RB
cord-290004-v3ruj5bq	162	17	be	be	VB
cord-290004-v3ruj5bq	162	18	an	an	DT
cord-290004-v3ruj5bq	162	19	issue	issue	NN
cord-290004-v3ruj5bq	162	20	of	of	IN
cord-290004-v3ruj5bq	162	21	vaccine	vaccine	NN
cord-290004-v3ruj5bq	162	22	availability	availability	NN
cord-290004-v3ruj5bq	162	23	in	in	IN
cord-290004-v3ruj5bq	162	24	low	low	JJ
cord-290004-v3ruj5bq	162	25	-	-	HYPH
cord-290004-v3ruj5bq	162	26	and	and	CC
cord-290004-v3ruj5bq	162	27	middle	middle	JJ
cord-290004-v3ruj5bq	162	28	-	-	HYPH
cord-290004-v3ruj5bq	162	29	income	income	NN
cord-290004-v3ruj5bq	162	30	countries	country	NNS
cord-290004-v3ruj5bq	162	31	.	.	.
cord-290004-v3ruj5bq	163	1	Therefore	therefore	RB
cord-290004-v3ruj5bq	163	2	,	,	,
cord-290004-v3ruj5bq	163	3	strategies	strategy	NNS
cord-290004-v3ruj5bq	163	4	are	be	VBP
cord-290004-v3ruj5bq	163	5	needed	need	VBN
cord-290004-v3ruj5bq	163	6	to	to	TO
cord-290004-v3ruj5bq	163	7	ensure	ensure	VB
cord-290004-v3ruj5bq	163	8	sufficient	sufficient	JJ
cord-290004-v3ruj5bq	163	9	and	and	CC
cord-290004-v3ruj5bq	163	10	equitable	equitable	JJ
cord-290004-v3ruj5bq	163	11	vaccine	vaccine	NN
cord-290004-v3ruj5bq	163	12	distribution	distribution	NN
cord-290004-v3ruj5bq	163	13	to	to	IN
cord-290004-v3ruj5bq	163	14	these	these	DT
cord-290004-v3ruj5bq	163	15	countries	country	NNS
cord-290004-v3ruj5bq	163	16	.	.	.
cord-290004-v3ruj5bq	164	1	Encouraging	encourage	VBG
cord-290004-v3ruj5bq	164	2	progress	progress	NN
cord-290004-v3ruj5bq	164	3	has	have	VBZ
cord-290004-v3ruj5bq	164	4	been	be	VBN
cord-290004-v3ruj5bq	164	5	made	make	VBN
cord-290004-v3ruj5bq	164	6	in	in	IN
cord-290004-v3ruj5bq	164	7	the	the	DT
cord-290004-v3ruj5bq	164	8	development	development	NN
cord-290004-v3ruj5bq	164	9	of	of	IN
cord-290004-v3ruj5bq	164	10	universal	universal	JJ
cord-290004-v3ruj5bq	164	11	influenza	influenza	NN
cord-290004-v3ruj5bq	164	12	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	164	13	.	.	.
cord-290004-v3ruj5bq	165	1	Future	future	JJ
cord-290004-v3ruj5bq	165	2	universal	universal	JJ
cord-290004-v3ruj5bq	165	3	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	165	4	will	will	MD
cord-290004-v3ruj5bq	165	5	likely	likely	RB
cord-290004-v3ruj5bq	165	6	consist	consist	VB
cord-290004-v3ruj5bq	165	7	of	of	IN
cord-290004-v3ruj5bq	165	8	a	a	DT
cord-290004-v3ruj5bq	165	9	combination	combination	NN
cord-290004-v3ruj5bq	165	10	of	of	IN
cord-290004-v3ruj5bq	165	11	different	different	JJ
cord-290004-v3ruj5bq	165	12	approaches	approach	NNS
cord-290004-v3ruj5bq	165	13	to	to	TO
cord-290004-v3ruj5bq	165	14	induce	induce	VB
cord-290004-v3ruj5bq	165	15	broad	broad	JJ
cord-290004-v3ruj5bq	165	16	immunity	immunity	NN
cord-290004-v3ruj5bq	165	17	to	to	IN
cord-290004-v3ruj5bq	165	18	influenza	influenza	NN
cord-290004-v3ruj5bq	165	19	.	.	.
cord-290004-v3ruj5bq	166	1	Ultimately	ultimately	RB
cord-290004-v3ruj5bq	166	2	,	,	,
cord-290004-v3ruj5bq	166	3	the	the	DT
cord-290004-v3ruj5bq	166	4	path	path	NN
cord-290004-v3ruj5bq	166	5	forward	forward	RB
cord-290004-v3ruj5bq	166	6	depends	depend	VBZ
cord-290004-v3ruj5bq	166	7	on	on	IN
cord-290004-v3ruj5bq	166	8	combined	combine	VBN
cord-290004-v3ruj5bq	166	9	action	action	NN
cord-290004-v3ruj5bq	166	10	from	from	IN
cord-290004-v3ruj5bq	166	11	governments	government	NNS
cord-290004-v3ruj5bq	166	12	,	,	,
cord-290004-v3ruj5bq	166	13	industries	industry	NNS
cord-290004-v3ruj5bq	166	14	,	,	,
cord-290004-v3ruj5bq	166	15	and	and	CC
cord-290004-v3ruj5bq	166	16	the	the	DT
cord-290004-v3ruj5bq	166	17	scientific	scientific	JJ
cord-290004-v3ruj5bq	166	18	community	community	NN
cord-290004-v3ruj5bq	166	19	.	.	.
cord-290004-v3ruj5bq	166	20	 	 	_SP
cord-290004-v3ruj5bq	167	1	Estimates	estimate	NNS
cord-290004-v3ruj5bq	167	2	of	of	IN
cord-290004-v3ruj5bq	167	3	global	global	JJ
cord-290004-v3ruj5bq	167	4	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	167	5	influenza	influenza	NN
cord-290004-v3ruj5bq	167	6	-	-	HYPH
cord-290004-v3ruj5bq	167	7	associated	associate	VBN
cord-290004-v3ruj5bq	167	8	respiratory	respiratory	JJ
cord-290004-v3ruj5bq	167	9	mortality	mortality	NN
cord-290004-v3ruj5bq	167	10	:	:	:
cord-290004-v3ruj5bq	167	11	A	a	DT
cord-290004-v3ruj5bq	167	12	modelling	modelling	NN
cord-290004-v3ruj5bq	167	13	study	study	NN
cord-290004-v3ruj5bq	168	1	In	in	IN
cord-290004-v3ruj5bq	168	2	vitro	vitro	FW
cord-290004-v3ruj5bq	168	3	and	and	CC
cord-290004-v3ruj5bq	168	4	in	in	IN
cord-290004-v3ruj5bq	168	5	vivo	vivo	NN
cord-290004-v3ruj5bq	168	6	characterization	characterization	NN
cord-290004-v3ruj5bq	168	7	of	of	IN
cord-290004-v3ruj5bq	168	8	new	new	JJ
cord-290004-v3ruj5bq	168	9	swine	swine	NN
cord-290004-v3ruj5bq	168	10	-	-	HYPH
cord-290004-v3ruj5bq	168	11	origin	origin	NN
cord-290004-v3ruj5bq	168	12	H1N1	H1N1	NNP
cord-290004-v3ruj5bq	168	13	influenza	influenza	NN
cord-290004-v3ruj5bq	168	14	viruses	virus	NNS
cord-290004-v3ruj5bq	169	1	The	the	DT
cord-290004-v3ruj5bq	169	2	future	future	NN
cord-290004-v3ruj5bq	169	3	of	of	IN
cord-290004-v3ruj5bq	169	4	influenza	influenza	NN
cord-290004-v3ruj5bq	169	5	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	169	6	:	:	:
cord-290004-v3ruj5bq	169	7	A	a	DT
cord-290004-v3ruj5bq	169	8	historical	historical	JJ
cord-290004-v3ruj5bq	169	9	and	and	CC
cord-290004-v3ruj5bq	169	10	clinical	clinical	JJ
cord-290004-v3ruj5bq	169	11	perspective	perspective	NN
cord-290004-v3ruj5bq	169	12	Development	Development	NNP
cord-290004-v3ruj5bq	169	13	of	of	IN
cord-290004-v3ruj5bq	169	14	a	a	DT
cord-290004-v3ruj5bq	169	15	universal	universal	JJ
cord-290004-v3ruj5bq	169	16	influenza	influenza	NN
cord-290004-v3ruj5bq	169	17	vaccine	vaccine	NN
cord-290004-v3ruj5bq	170	1	A	a	DT
cord-290004-v3ruj5bq	170	2	universal	universal	JJ
cord-290004-v3ruj5bq	170	3	influenza	influenza	NN
cord-290004-v3ruj5bq	170	4	vaccine	vaccine	NN
cord-290004-v3ruj5bq	170	5	:	:	:
cord-290004-v3ruj5bq	171	1	The	the	DT
cord-290004-v3ruj5bq	171	2	strategic	strategic	JJ
cord-290004-v3ruj5bq	171	3	plan	plan	NN
cord-290004-v3ruj5bq	171	4	for	for	IN
cord-290004-v3ruj5bq	171	5	the	the	DT
cord-290004-v3ruj5bq	171	6	national	national	NNP
cord-290004-v3ruj5bq	171	7	institute	institute	NNP
cord-290004-v3ruj5bq	171	8	of	of	IN
cord-290004-v3ruj5bq	171	9	allergy	allergy	NNP
cord-290004-v3ruj5bq	171	10	and	and	CC
cord-290004-v3ruj5bq	171	11	infectious	infectious	JJ
cord-290004-v3ruj5bq	171	12	diseases	disease	NNS
cord-290004-v3ruj5bq	172	1	The	the	DT
cord-290004-v3ruj5bq	172	2	Compelling	compelling	JJ
cord-290004-v3ruj5bq	172	3	Need	need	NN
cord-290004-v3ruj5bq	172	4	for	for	IN
cord-290004-v3ruj5bq	172	5	Game	game	NN
cord-290004-v3ruj5bq	172	6	-	-	HYPH
cord-290004-v3ruj5bq	172	7	Changing	change	VBG
cord-290004-v3ruj5bq	172	8	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	172	9	Vaccines	Vaccines	NNPS
cord-290004-v3ruj5bq	172	10	an	an	DT
cord-290004-v3ruj5bq	172	11	Analysis	Analysis	NNP
cord-290004-v3ruj5bq	172	12	of	of	IN
cord-290004-v3ruj5bq	172	13	the	the	DT
cord-290004-v3ruj5bq	172	14	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	172	15	Vaccine	Vaccine	NNP
cord-290004-v3ruj5bq	172	16	Enterpris	Enterpris	NNP
cord-290004-v3ruj5bq	173	1	The	the	DT
cord-290004-v3ruj5bq	173	2	role	role	NN
cord-290004-v3ruj5bq	173	3	of	of	IN
cord-290004-v3ruj5bq	173	4	Fc	Fc	NNP
cord-290004-v3ruj5bq	173	5	-	-	HYPH
cord-290004-v3ruj5bq	173	6	FcγR	FcγR	NNP
cord-290004-v3ruj5bq	173	7	interactions	interaction	NNS
cord-290004-v3ruj5bq	173	8	in	in	IN
cord-290004-v3ruj5bq	173	9	IgG	igg	NN
cord-290004-v3ruj5bq	173	10	-	-	HYPH
cord-290004-v3ruj5bq	173	11	mediated	mediate	VBN
cord-290004-v3ruj5bq	173	12	microbial	microbial	JJ
cord-290004-v3ruj5bq	173	13	neutralization	neutralization	NN
cord-290004-v3ruj5bq	173	14	Broadly	broadly	RB
cord-290004-v3ruj5bq	173	15	neutralizing	neutralize	VBG
cord-290004-v3ruj5bq	173	16	anti	anti	JJ
cord-290004-v3ruj5bq	173	17	-	-	JJ
cord-290004-v3ruj5bq	173	18	influenza	influenza	JJ
cord-290004-v3ruj5bq	173	19	antibodies	antibody	NNS
cord-290004-v3ruj5bq	173	20	require	require	VBP
cord-290004-v3ruj5bq	173	21	Fc	Fc	NNP
cord-290004-v3ruj5bq	173	22	receptor	receptor	NN
cord-290004-v3ruj5bq	173	23	engagement	engagement	NN
cord-290004-v3ruj5bq	173	24	for	for	IN
cord-290004-v3ruj5bq	173	25	in	in	IN
cord-290004-v3ruj5bq	173	26	vivo	vivo	NN
cord-290004-v3ruj5bq	173	27	protection	protection	NN
cord-290004-v3ruj5bq	173	28	Highly	highly	RB
cord-290004-v3ruj5bq	173	29	conserved	conserve	VBD
cord-290004-v3ruj5bq	173	30	protective	protective	JJ
cord-290004-v3ruj5bq	173	31	epitopes	epitope	NNS
cord-290004-v3ruj5bq	173	32	on	on	IN
cord-290004-v3ruj5bq	173	33	influenza	influenza	NN
cord-290004-v3ruj5bq	173	34	B	b	NN
cord-290004-v3ruj5bq	173	35	viruses	virus	NNS
cord-290004-v3ruj5bq	173	36	Natural	natural	JJ
cord-290004-v3ruj5bq	173	37	T	T	NNP
cord-290004-v3ruj5bq	173	38	cell	cell	NN
cord-290004-v3ruj5bq	173	39	-	-	HYPH
cord-290004-v3ruj5bq	173	40	mediated	mediate	VBN
cord-290004-v3ruj5bq	173	41	protection	protection	NN
cord-290004-v3ruj5bq	173	42	against	against	IN
cord-290004-v3ruj5bq	173	43	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	173	44	and	and	CC
cord-290004-v3ruj5bq	173	45	pandemic	pandemic	NN
cord-290004-v3ruj5bq	173	46	influenza	influenza	NN
cord-290004-v3ruj5bq	173	47	.	.	.
cord-290004-v3ruj5bq	174	1	Results	result	NNS
cord-290004-v3ruj5bq	174	2	of	of	IN
cord-290004-v3ruj5bq	174	3	the	the	DT
cord-290004-v3ruj5bq	174	4	flu	flu	NN
cord-290004-v3ruj5bq	174	5	watch	watch	NN
cord-290004-v3ruj5bq	174	6	cohort	cohort	NN
cord-290004-v3ruj5bq	174	7	study	study	NN
cord-290004-v3ruj5bq	174	8	Cytotoxic	Cytotoxic	NNP
cord-290004-v3ruj5bq	174	9	T	T	NNP
cord-290004-v3ruj5bq	174	10	-	-	HYPH
cord-290004-v3ruj5bq	174	11	cell	cell	NN
cord-290004-v3ruj5bq	174	12	immunity	immunity	NN
cord-290004-v3ruj5bq	174	13	to	to	IN
cord-290004-v3ruj5bq	175	1	influenza	influenza	NN
cord-290004-v3ruj5bq	175	2	Preexisting	preexist	VBG
cord-290004-v3ruj5bq	175	3	influenza	influenza	NN
cord-290004-v3ruj5bq	175	4	-	-	HYPH
cord-290004-v3ruj5bq	175	5	specific	specific	JJ
cord-290004-v3ruj5bq	176	1	CD4	CD4	NNP
cord-290004-v3ruj5bq	176	2	+	+	CC
cord-290004-v3ruj5bq	176	3	T	t	NN
cord-290004-v3ruj5bq	176	4	cells	cell	NNS
cord-290004-v3ruj5bq	176	5	correlate	correlate	VBP
cord-290004-v3ruj5bq	176	6	with	with	IN
cord-290004-v3ruj5bq	176	7	disease	disease	NN
cord-290004-v3ruj5bq	176	8	protection	protection	NN
cord-290004-v3ruj5bq	176	9	against	against	IN
cord-290004-v3ruj5bq	176	10	influenza	influenza	NN
cord-290004-v3ruj5bq	176	11	challenge	challenge	NN
cord-290004-v3ruj5bq	176	12	in	in	IN
cord-290004-v3ruj5bq	176	13	humans	human	NNS
cord-290004-v3ruj5bq	176	14	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	176	15	virus	virus	NN
cord-290004-v3ruj5bq	176	16	:	:	:
cord-290004-v3ruj5bq	176	17	Dealing	deal	VBG
cord-290004-v3ruj5bq	176	18	with	with	IN
cord-290004-v3ruj5bq	176	19	a	a	DT
cord-290004-v3ruj5bq	176	20	drifting	drifting	NN
cord-290004-v3ruj5bq	176	21	and	and	CC
cord-290004-v3ruj5bq	176	22	shifting	shift	VBG
cord-290004-v3ruj5bq	176	23	pathogen	pathogen	NN
cord-290004-v3ruj5bq	176	24	H3N2	H3N2	NNP
cord-290004-v3ruj5bq	176	25	influenza	influenza	NN
cord-290004-v3ruj5bq	176	26	viruses	virus	NNS
cord-290004-v3ruj5bq	176	27	in	in	IN
cord-290004-v3ruj5bq	176	28	humans	human	NNS
cord-290004-v3ruj5bq	176	29	:	:	:
cord-290004-v3ruj5bq	176	30	Viral	viral	JJ
cord-290004-v3ruj5bq	176	31	mechanisms	mechanism	NNS
cord-290004-v3ruj5bq	176	32	,	,	,
cord-290004-v3ruj5bq	176	33	evolution	evolution	NN
cord-290004-v3ruj5bq	176	34	,	,	,
cord-290004-v3ruj5bq	176	35	and	and	CC
cord-290004-v3ruj5bq	176	36	evaluation	evaluation	NN
cord-290004-v3ruj5bq	176	37	.	.	.
cord-290004-v3ruj5bq	177	1	Hum	Hum	NNP
cord-290004-v3ruj5bq	177	2	.	.	.
cord-290004-v3ruj5bq	178	1	Vaccines	vaccine	NNS
cord-290004-v3ruj5bq	178	2	Immunother	Immunother	NNP
cord-290004-v3ruj5bq	178	3	Efforts	Efforts	NNPS
cord-290004-v3ruj5bq	178	4	to	to	TO
cord-290004-v3ruj5bq	178	5	improve	improve	VB
cord-290004-v3ruj5bq	178	6	the	the	DT
cord-290004-v3ruj5bq	178	7	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	178	8	influenza	influenza	NN
cord-290004-v3ruj5bq	178	9	vaccine	vaccine	NN
cord-290004-v3ruj5bq	178	10	Safety	Safety	NNP
cord-290004-v3ruj5bq	178	11	,	,	,
cord-290004-v3ruj5bq	178	12	efficacy	efficacy	NN
cord-290004-v3ruj5bq	178	13	,	,	,
cord-290004-v3ruj5bq	178	14	and	and	CC
cord-290004-v3ruj5bq	178	15	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	178	16	of	of	IN
cord-290004-v3ruj5bq	178	17	Flublok	Flublok	NNP
cord-290004-v3ruj5bq	178	18	in	in	IN
cord-290004-v3ruj5bq	178	19	the	the	DT
cord-290004-v3ruj5bq	178	20	prevention	prevention	NN
cord-290004-v3ruj5bq	178	21	of	of	IN
cord-290004-v3ruj5bq	178	22	seasonal	seasonal	JJ
cord-290004-v3ruj5bq	178	23	influenza	influenza	NN
cord-290004-v3ruj5bq	178	24	in	in	IN
cord-290004-v3ruj5bq	178	25	adults	adult	NNS
cord-290004-v3ruj5bq	178	26	Adjuvanted	adjuvante	VBN
cord-290004-v3ruj5bq	178	27	influenza	influenza	NN
cord-290004-v3ruj5bq	178	28	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	178	29	.	.	.
cord-290004-v3ruj5bq	179	1	Hum	Hum	NNP
cord-290004-v3ruj5bq	179	2	.	.	.
cord-290004-v3ruj5bq	180	1	Vaccines	vaccine	NNS
cord-290004-v3ruj5bq	180	2	Immunother	Immunother	NNP
cord-290004-v3ruj5bq	180	3	Van	Van	NNP
cord-290004-v3ruj5bq	180	4	der	der	NNP
cord-290004-v3ruj5bq	181	1	Most	Most	JJS
cord-290004-v3ruj5bq	181	2	,	,	,
cord-290004-v3ruj5bq	181	3	R.	R.	NNP
cord-290004-v3ruj5bq	181	4	Investigating	investigate	VBG
cord-290004-v3ruj5bq	181	5	the	the	DT
cord-290004-v3ruj5bq	181	6	effect	effect	NN
cord-290004-v3ruj5bq	181	7	of	of	IN
cord-290004-v3ruj5bq	181	8	AS03	AS03	NNP
cord-290004-v3ruj5bq	181	9	adjuvant	adjuvant	JJ
cord-290004-v3ruj5bq	181	10	on	on	IN
cord-290004-v3ruj5bq	181	11	the	the	DT
cord-290004-v3ruj5bq	181	12	plasma	plasma	NN
cord-290004-v3ruj5bq	181	13	cell	cell	NN
cord-290004-v3ruj5bq	181	14	repertoire	repertoire	NN
cord-290004-v3ruj5bq	181	15	following	follow	VBG
cord-290004-v3ruj5bq	181	16	pH1N1	pH1N1	NNP
cord-290004-v3ruj5bq	181	17	influenza	influenza	NN
cord-290004-v3ruj5bq	181	18	vaccination	vaccination	NN
cord-290004-v3ruj5bq	181	19	Adjuvant	Adjuvant	NNP
cord-290004-v3ruj5bq	181	20	System	System	NNP
cord-290004-v3ruj5bq	181	21	AS03	AS03	NNP
cord-290004-v3ruj5bq	181	22	containing	contain	VBG
cord-290004-v3ruj5bq	181	23	α	α	NN
cord-290004-v3ruj5bq	181	24	-	-	HYPH
cord-290004-v3ruj5bq	181	25	tocopherol	tocopherol	NN
cord-290004-v3ruj5bq	181	26	modulates	modulate	VBZ
cord-290004-v3ruj5bq	181	27	innate	innate	JJ
cord-290004-v3ruj5bq	181	28	immune	immune	JJ
cord-290004-v3ruj5bq	181	29	response	response	NN
cord-290004-v3ruj5bq	181	30	and	and	CC
cord-290004-v3ruj5bq	181	31	leads	lead	VBZ
cord-290004-v3ruj5bq	181	32	to	to	IN
cord-290004-v3ruj5bq	181	33	improved	improve	VBN
cord-290004-v3ruj5bq	181	34	adaptive	adaptive	JJ
cord-290004-v3ruj5bq	181	35	immunity	immunity	NN
cord-290004-v3ruj5bq	181	36	Recombinant	recombinant	JJ
cord-290004-v3ruj5bq	181	37	cold	cold	NN
cord-290004-v3ruj5bq	181	38	-	-	HYPH
cord-290004-v3ruj5bq	181	39	adapted	adapt	VBN
cord-290004-v3ruj5bq	181	40	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	181	41	influenza	influenza	NN
cord-290004-v3ruj5bq	181	42	A	a	DT
cord-290004-v3ruj5bq	181	43	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	181	44	for	for	IN
cord-290004-v3ruj5bq	181	45	use	use	NN
cord-290004-v3ruj5bq	181	46	in	in	IN
cord-290004-v3ruj5bq	181	47	children	child	NNS
cord-290004-v3ruj5bq	181	48	:	:	:
cord-290004-v3ruj5bq	182	1	Molecular	molecular	JJ
cord-290004-v3ruj5bq	182	2	genetic	genetic	JJ
cord-290004-v3ruj5bq	182	3	analysis	analysis	NN
cord-290004-v3ruj5bq	182	4	of	of	IN
cord-290004-v3ruj5bq	182	5	the	the	DT
cord-290004-v3ruj5bq	182	6	cold	cold	RB
cord-290004-v3ruj5bq	182	7	-	-	HYPH
cord-290004-v3ruj5bq	182	8	adapted	adapt	VBN
cord-290004-v3ruj5bq	182	9	donor	donor	NN
cord-290004-v3ruj5bq	182	10	and	and	CC
cord-290004-v3ruj5bq	182	11	recombinants	recombinant	NNS
cord-290004-v3ruj5bq	183	1	Multiple	multiple	JJ
cord-290004-v3ruj5bq	183	2	amino	amino	NN
cord-290004-v3ruj5bq	183	3	acid	acid	NN
cord-290004-v3ruj5bq	183	4	residues	residue	NNS
cord-290004-v3ruj5bq	183	5	confer	confer	VBP
cord-290004-v3ruj5bq	183	6	temperature	temperature	NN
cord-290004-v3ruj5bq	183	7	sensitivity	sensitivity	NN
cord-290004-v3ruj5bq	183	8	to	to	IN
cord-290004-v3ruj5bq	183	9	human	human	JJ
cord-290004-v3ruj5bq	183	10	influenza	influenza	NN
cord-290004-v3ruj5bq	183	11	virus	virus	NN
cord-290004-v3ruj5bq	183	12	vaccine	vaccine	NN
cord-290004-v3ruj5bq	183	13	strains	strain	NNS
cord-290004-v3ruj5bq	183	14	(	(	-LRB-
cord-290004-v3ruj5bq	183	15	FluMist	FluMist	NNP
cord-290004-v3ruj5bq	183	16	)	)	-RRB-
cord-290004-v3ruj5bq	183	17	derived	derive	VBN
cord-290004-v3ruj5bq	183	18	from	from	IN
cord-290004-v3ruj5bq	183	19	cold	cold	NN
cord-290004-v3ruj5bq	183	20	-	-	HYPH
cord-290004-v3ruj5bq	183	21	adapted	adapt	VBN
cord-290004-v3ruj5bq	183	22	A	A	NNP
cord-290004-v3ruj5bq	183	23	/	/	SYM
cord-290004-v3ruj5bq	183	24	Ann	Ann	NNP
cord-290004-v3ruj5bq	183	25	Arbor/6/60	Arbor/6/60	NNP
cord-290004-v3ruj5bq	184	1	The	the	DT
cord-290004-v3ruj5bq	184	2	role	role	NN
cord-290004-v3ruj5bq	184	3	of	of	IN
cord-290004-v3ruj5bq	184	4	nasal	nasal	NN
cord-290004-v3ruj5bq	184	5	IgA	IgA	NNP
cord-290004-v3ruj5bq	184	6	in	in	IN
cord-290004-v3ruj5bq	184	7	children	child	NNS
cord-290004-v3ruj5bq	184	8	vaccinated	vaccinate	VBN
cord-290004-v3ruj5bq	184	9	with	with	IN
cord-290004-v3ruj5bq	184	10	live	live	JJ
cord-290004-v3ruj5bq	184	11	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	184	12	influenza	influenza	NN
cord-290004-v3ruj5bq	184	13	vaccine	vaccine	NN
cord-290004-v3ruj5bq	184	14	Comparisons	comparison	NNS
cord-290004-v3ruj5bq	184	15	of	of	IN
cord-290004-v3ruj5bq	184	16	the	the	DT
cord-290004-v3ruj5bq	184	17	humoral	humoral	JJ
cord-290004-v3ruj5bq	184	18	and	and	CC
cord-290004-v3ruj5bq	184	19	cellular	cellular	JJ
cord-290004-v3ruj5bq	184	20	immune	immune	JJ
cord-290004-v3ruj5bq	184	21	responses	response	NNS
cord-290004-v3ruj5bq	184	22	induced	induce	VBN
cord-290004-v3ruj5bq	184	23	by	by	IN
cord-290004-v3ruj5bq	184	24	live	live	JJ
cord-290004-v3ruj5bq	184	25	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	184	26	influenza	influenza	NN
cord-290004-v3ruj5bq	184	27	vaccine	vaccine	NN
cord-290004-v3ruj5bq	184	28	and	and	CC
cord-290004-v3ruj5bq	184	29	inactivated	inactivate	VBN
cord-290004-v3ruj5bq	184	30	influenza	influenza	NN
cord-290004-v3ruj5bq	184	31	vaccine	vaccine	NN
cord-290004-v3ruj5bq	184	32	in	in	IN
cord-290004-v3ruj5bq	184	33	adults	adult	NNS
cord-290004-v3ruj5bq	184	34	Immune	immune	VBP
cord-290004-v3ruj5bq	184	35	responses	response	NNS
cord-290004-v3ruj5bq	184	36	after	after	IN
cord-290004-v3ruj5bq	184	37	live	live	JJ
cord-290004-v3ruj5bq	184	38	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	184	39	influenza	influenza	NN
cord-290004-v3ruj5bq	184	40	vaccination	vaccination	NN
cord-290004-v3ruj5bq	184	41	Live	live	VB
cord-290004-v3ruj5bq	184	42	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	184	43	versus	versus	IN
cord-290004-v3ruj5bq	184	44	inactivated	inactivate	VBN
cord-290004-v3ruj5bq	184	45	influenza	influenza	NN
cord-290004-v3ruj5bq	184	46	vaccine	vaccine	NN
cord-290004-v3ruj5bq	184	47	in	in	IN
cord-290004-v3ruj5bq	184	48	infants	infant	NNS
cord-290004-v3ruj5bq	184	49	and	and	CC
cord-290004-v3ruj5bq	184	50	young	young	JJ
cord-290004-v3ruj5bq	184	51	children	child	NNS
cord-290004-v3ruj5bq	185	1	Novel	novel	JJ
cord-290004-v3ruj5bq	185	2	platforms	platform	NNS
cord-290004-v3ruj5bq	185	3	for	for	IN
cord-290004-v3ruj5bq	185	4	the	the	DT
cord-290004-v3ruj5bq	185	5	development	development	NN
cord-290004-v3ruj5bq	185	6	of	of	IN
cord-290004-v3ruj5bq	185	7	a	a	DT
cord-290004-v3ruj5bq	185	8	universal	universal	JJ
cord-290004-v3ruj5bq	185	9	influenza	influenza	NN
cord-290004-v3ruj5bq	185	10	vaccine	vaccine	NN
cord-290004-v3ruj5bq	185	11	Multi	multi	JJ
cord-290004-v3ruj5bq	185	12	-	-	JJ
cord-290004-v3ruj5bq	185	13	antigen	antigen	JJ
cord-290004-v3ruj5bq	185	14	avian	avian	JJ
cord-290004-v3ruj5bq	185	15	influenza	influenza	NN
cord-290004-v3ruj5bq	185	16	a	a	DT
cord-290004-v3ruj5bq	185	17	(	(	-LRB-
cord-290004-v3ruj5bq	185	18	H7N9	H7N9	NNP
cord-290004-v3ruj5bq	185	19	)	)	-RRB-
cord-290004-v3ruj5bq	185	20	virus	virus	NN
cord-290004-v3ruj5bq	185	21	-	-	HYPH
cord-290004-v3ruj5bq	185	22	like	like	JJ
cord-290004-v3ruj5bq	185	23	particles	particle	NNS
cord-290004-v3ruj5bq	185	24	:	:	:
cord-290004-v3ruj5bq	186	1	Particulate	particulate	NN
cord-290004-v3ruj5bq	186	2	characterizations	characterization	NNS
cord-290004-v3ruj5bq	186	3	and	and	CC
cord-290004-v3ruj5bq	186	4	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	186	5	evaluation	evaluation	NN
cord-290004-v3ruj5bq	186	6	in	in	IN
cord-290004-v3ruj5bq	186	7	murine	murine	JJ
cord-290004-v3ruj5bq	186	8	and	and	CC
cord-290004-v3ruj5bq	186	9	avian	avian	JJ
cord-290004-v3ruj5bq	186	10	models	model	NNS
cord-290004-v3ruj5bq	186	11	Virus	virus	NN
cord-290004-v3ruj5bq	186	12	-	-	HYPH
cord-290004-v3ruj5bq	186	13	like	like	JJ
cord-290004-v3ruj5bq	186	14	particles	particle	NNS
cord-290004-v3ruj5bq	186	15	containing	contain	VBG
cord-290004-v3ruj5bq	186	16	multiple	multiple	JJ
cord-290004-v3ruj5bq	186	17	M2	M2	NNP
cord-290004-v3ruj5bq	186	18	extracellular	extracellular	JJ
cord-290004-v3ruj5bq	186	19	domains	domain	NNS
cord-290004-v3ruj5bq	186	20	confer	confer	VBP
cord-290004-v3ruj5bq	186	21	improved	improve	VBN
cord-290004-v3ruj5bq	186	22	cross	cross	NN
cord-290004-v3ruj5bq	186	23	-	-	NN
cord-290004-v3ruj5bq	186	24	protection	protection	NN
cord-290004-v3ruj5bq	186	25	against	against	IN
cord-290004-v3ruj5bq	186	26	various	various	JJ
cord-290004-v3ruj5bq	186	27	subtypes	subtype	NNS
cord-290004-v3ruj5bq	186	28	of	of	IN
cord-290004-v3ruj5bq	186	29	influenza	influenza	NN
cord-290004-v3ruj5bq	186	30	virus	virus	NN
cord-290004-v3ruj5bq	187	1	An	an	DT
cord-290004-v3ruj5bq	187	2	intranasal	intranasal	NN
cord-290004-v3ruj5bq	187	3	virus	virus	NN
cord-290004-v3ruj5bq	187	4	-	-	HYPH
cord-290004-v3ruj5bq	187	5	like	like	JJ
cord-290004-v3ruj5bq	187	6	particle	particle	NN
cord-290004-v3ruj5bq	187	7	vaccine	vaccine	NN
cord-290004-v3ruj5bq	187	8	broadly	broadly	RB
cord-290004-v3ruj5bq	187	9	protects	protect	VBZ
cord-290004-v3ruj5bq	187	10	mice	mouse	NNS
cord-290004-v3ruj5bq	187	11	from	from	IN
cord-290004-v3ruj5bq	187	12	multiple	multiple	JJ
cord-290004-v3ruj5bq	187	13	subtypes	subtype	NNS
cord-290004-v3ruj5bq	187	14	of	of	IN
cord-290004-v3ruj5bq	187	15	influenza	influenza	NN
cord-290004-v3ruj5bq	187	16	A	a	DT
cord-290004-v3ruj5bq	187	17	virus	virus	NN
cord-290004-v3ruj5bq	187	18	TLR	tlr	NN
cord-290004-v3ruj5bq	187	19	-	-	HYPH
cord-290004-v3ruj5bq	187	20	based	base	VBN
cord-290004-v3ruj5bq	187	21	immune	immune	JJ
cord-290004-v3ruj5bq	187	22	adjuvants	adjuvant	NNS
cord-290004-v3ruj5bq	187	23	Heterosubtypic	Heterosubtypic	NNP
cord-290004-v3ruj5bq	187	24	influenza	influenza	NN
cord-290004-v3ruj5bq	187	25	protection	protection	NN
cord-290004-v3ruj5bq	187	26	elicited	elicit	VBN
cord-290004-v3ruj5bq	187	27	by	by	IN
cord-290004-v3ruj5bq	187	28	double	double	RB
cord-290004-v3ruj5bq	187	29	-	-	HYPH
cord-290004-v3ruj5bq	187	30	layered	layered	JJ
cord-290004-v3ruj5bq	187	31	polypeptide	polypeptide	NN
cord-290004-v3ruj5bq	187	32	nanoparticles	nanoparticle	NNS
cord-290004-v3ruj5bq	187	33	in	in	IN
cord-290004-v3ruj5bq	187	34	mice	mouse	NNS
cord-290004-v3ruj5bq	188	1	Synthetic	synthetic	JJ
cord-290004-v3ruj5bq	188	2	multi	multi	JJ
cord-290004-v3ruj5bq	188	3	-	-	JJ
cord-290004-v3ruj5bq	188	4	epitope	epitope	JJ
cord-290004-v3ruj5bq	188	5	peptides	peptide	NNS
cord-290004-v3ruj5bq	188	6	identified	identify	VBN
cord-290004-v3ruj5bq	188	7	in	in	IN
cord-290004-v3ruj5bq	188	8	silico	silico	NNS
cord-290004-v3ruj5bq	188	9	induce	induce	VBP
cord-290004-v3ruj5bq	188	10	protective	protective	JJ
cord-290004-v3ruj5bq	188	11	immunity	immunity	NN
cord-290004-v3ruj5bq	188	12	against	against	IN
cord-290004-v3ruj5bq	188	13	multiple	multiple	JJ
cord-290004-v3ruj5bq	188	14	influenza	influenza	NN
cord-290004-v3ruj5bq	188	15	serotypes	serotype	NNS
cord-290004-v3ruj5bq	188	16	Rapidly	rapidly	RB
cord-290004-v3ruj5bq	188	17	produced	produce	VBD
cord-290004-v3ruj5bq	188	18	SAM	SAM	NNP
cord-290004-v3ruj5bq	188	19	®	®	POS
cord-290004-v3ruj5bq	188	20	vaccine	vaccine	NN
cord-290004-v3ruj5bq	188	21	against	against	IN
cord-290004-v3ruj5bq	188	22	H7N9	H7N9	NNP
cord-290004-v3ruj5bq	188	23	influenza	influenza	NN
cord-290004-v3ruj5bq	188	24	is	be	VBZ
cord-290004-v3ruj5bq	188	25	immunogenic	immunogenic	JJ
cord-290004-v3ruj5bq	188	26	in	in	IN
cord-290004-v3ruj5bq	188	27	mice	mouse	NNS
cord-290004-v3ruj5bq	189	1	A	a	DT
cord-290004-v3ruj5bq	189	2	SARS	SARS	NNP
cord-290004-v3ruj5bq	189	3	DNA	DNA	NNP
cord-290004-v3ruj5bq	189	4	vaccine	vaccine	NN
cord-290004-v3ruj5bq	189	5	induces	induce	VBZ
cord-290004-v3ruj5bq	189	6	neutralizing	neutralize	VBG
cord-290004-v3ruj5bq	189	7	antibody	antibody	NN
cord-290004-v3ruj5bq	189	8	and	and	CC
cord-290004-v3ruj5bq	189	9	cellular	cellular	JJ
cord-290004-v3ruj5bq	189	10	immune	immune	JJ
cord-290004-v3ruj5bq	189	11	responses	response	NNS
cord-290004-v3ruj5bq	189	12	in	in	IN
cord-290004-v3ruj5bq	189	13	healthy	healthy	JJ
cord-290004-v3ruj5bq	189	14	adults	adult	NNS
cord-290004-v3ruj5bq	189	15	in	in	IN
cord-290004-v3ruj5bq	189	16	a	a	DT
cord-290004-v3ruj5bq	189	17	Phase	phase	NN
cord-290004-v3ruj5bq	190	1	I	-PRON-	PRP
cord-290004-v3ruj5bq	190	2	clinical	clinical	JJ
cord-290004-v3ruj5bq	190	3	trial	trial	NN
cord-290004-v3ruj5bq	191	1	Viral	viral	JJ
cord-290004-v3ruj5bq	191	2	vector	vector	NN
cord-290004-v3ruj5bq	191	3	-	-	HYPH
cord-290004-v3ruj5bq	191	4	based	base	VBN
cord-290004-v3ruj5bq	191	5	influenza	influenza	NN
cord-290004-v3ruj5bq	191	6	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	191	7	.	.	.
cord-290004-v3ruj5bq	192	1	Hum	Hum	NNP
cord-290004-v3ruj5bq	192	2	.	.	.
cord-290004-v3ruj5bq	193	1	Vaccines	vaccine	NNS
cord-290004-v3ruj5bq	193	2	Immunother	Immunother	NNP
cord-290004-v3ruj5bq	193	3	Safety	Safety	NNP
cord-290004-v3ruj5bq	193	4	and	and	CC
cord-290004-v3ruj5bq	193	5	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	193	6	of	of	IN
cord-290004-v3ruj5bq	193	7	an	an	DT
cord-290004-v3ruj5bq	193	8	oral	oral	JJ
cord-290004-v3ruj5bq	193	9	,	,	,
cord-290004-v3ruj5bq	193	10	replicating	replicate	VBG
cord-290004-v3ruj5bq	193	11	adenovirus	adenovirus	NN
cord-290004-v3ruj5bq	193	12	serotype	serotype	NN
cord-290004-v3ruj5bq	193	13	4	4	CD
cord-290004-v3ruj5bq	193	14	vector	vector	NN
cord-290004-v3ruj5bq	193	15	vaccine	vaccine	NN
cord-290004-v3ruj5bq	193	16	for	for	IN
cord-290004-v3ruj5bq	193	17	H5N1	H5N1	NNP
cord-290004-v3ruj5bq	193	18	influenza	influenza	NN
cord-290004-v3ruj5bq	193	19	:	:	:
cord-290004-v3ruj5bq	193	20	A	a	DT
cord-290004-v3ruj5bq	193	21	randomised	randomised	JJ
cord-290004-v3ruj5bq	193	22	,	,	,
cord-290004-v3ruj5bq	193	23	double	double	JJ
cord-290004-v3ruj5bq	193	24	-	-	HYPH
cord-290004-v3ruj5bq	193	25	blind	blind	JJ
cord-290004-v3ruj5bq	193	26	,	,	,
cord-290004-v3ruj5bq	193	27	placebo	placebo	NN
cord-290004-v3ruj5bq	193	28	-	-	HYPH
cord-290004-v3ruj5bq	193	29	controlled	control	VBN
cord-290004-v3ruj5bq	193	30	,	,	,
cord-290004-v3ruj5bq	193	31	phase	phase	NN
cord-290004-v3ruj5bq	193	32	1	1	CD
cord-290004-v3ruj5bq	193	33	study	study	NN
cord-290004-v3ruj5bq	193	34	Preliminary	preliminary	JJ
cord-290004-v3ruj5bq	193	35	assessment	assessment	NN
cord-290004-v3ruj5bq	193	36	of	of	IN
cord-290004-v3ruj5bq	193	37	the	the	DT
cord-290004-v3ruj5bq	193	38	efficacy	efficacy	NN
cord-290004-v3ruj5bq	193	39	of	of	IN
cord-290004-v3ruj5bq	193	40	a	a	DT
cord-290004-v3ruj5bq	193	41	t	t	NN
cord-290004-v3ruj5bq	193	42	-	-	HYPH
cord-290004-v3ruj5bq	193	43	cell	cell	NN
cord-290004-v3ruj5bq	193	44	-	-	HYPH
cord-290004-v3ruj5bq	193	45	based	base	VBN
cord-290004-v3ruj5bq	193	46	influenza	influenza	NN
cord-290004-v3ruj5bq	193	47	vaccine	vaccine	NN
cord-290004-v3ruj5bq	193	48	,	,	,
cord-290004-v3ruj5bq	193	49	MVA	MVA	NNP
cord-290004-v3ruj5bq	193	50	-	-	HYPH
cord-290004-v3ruj5bq	193	51	NP+	NP+	NNP
cord-290004-v3ruj5bq	193	52	M1	M1	NNP
cord-290004-v3ruj5bq	193	53	,	,	,
cord-290004-v3ruj5bq	193	54	in	in	IN
cord-290004-v3ruj5bq	193	55	humans	human	NNS
cord-290004-v3ruj5bq	193	56	Safety	Safety	NNP
cord-290004-v3ruj5bq	193	57	and	and	CC
cord-290004-v3ruj5bq	193	58	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	193	59	of	of	IN
cord-290004-v3ruj5bq	193	60	adenovirus	adenovirus	NN
cord-290004-v3ruj5bq	193	61	-	-	HYPH
cord-290004-v3ruj5bq	193	62	vectored	vectore	VBN
cord-290004-v3ruj5bq	193	63	nasal	nasal	NN
cord-290004-v3ruj5bq	193	64	and	and	CC
cord-290004-v3ruj5bq	193	65	epicutaneous	epicutaneous	JJ
cord-290004-v3ruj5bq	193	66	influenza	influenza	NN
cord-290004-v3ruj5bq	193	67	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	193	68	in	in	IN
cord-290004-v3ruj5bq	193	69	humans	human	NNS
cord-290004-v3ruj5bq	193	70	Failure	failure	NN
cord-290004-v3ruj5bq	193	71	of	of	IN
cord-290004-v3ruj5bq	193	72	a	a	DT
cord-290004-v3ruj5bq	193	73	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	193	74	fowl	fowl	NN
cord-290004-v3ruj5bq	193	75	poxvirus	poxvirus	NNP
cord-290004-v3ruj5bq	193	76	vaccine	vaccine	NN
cord-290004-v3ruj5bq	193	77	containing	contain	VBG
cord-290004-v3ruj5bq	193	78	an	an	DT
cord-290004-v3ruj5bq	193	79	avian	avian	JJ
cord-290004-v3ruj5bq	193	80	influenza	influenza	NN
cord-290004-v3ruj5bq	193	81	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	193	82	gene	gene	NN
cord-290004-v3ruj5bq	193	83	to	to	TO
cord-290004-v3ruj5bq	193	84	provide	provide	VB
cord-290004-v3ruj5bq	193	85	consistent	consistent	JJ
cord-290004-v3ruj5bq	193	86	protection	protection	NN
cord-290004-v3ruj5bq	193	87	against	against	IN
cord-290004-v3ruj5bq	193	88	influenza	influenza	NN
cord-290004-v3ruj5bq	193	89	in	in	IN
cord-290004-v3ruj5bq	193	90	chickens	chicken	NNS
cord-290004-v3ruj5bq	193	91	preimmunized	preimmunize	VBN
cord-290004-v3ruj5bq	193	92	with	with	IN
cord-290004-v3ruj5bq	193	93	a	a	DT
cord-290004-v3ruj5bq	193	94	fowl	fowl	NN
cord-290004-v3ruj5bq	193	95	pox	pox	NN
cord-290004-v3ruj5bq	193	96	vaccine	vaccine	NN
cord-290004-v3ruj5bq	193	97	Universal	Universal	NNP
cord-290004-v3ruj5bq	193	98	influenza	influenza	NN
cord-290004-v3ruj5bq	193	99	virus	virus	NN
cord-290004-v3ruj5bq	193	100	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	193	101	that	that	WDT
cord-290004-v3ruj5bq	193	102	target	target	VBP
cord-290004-v3ruj5bq	193	103	the	the	DT
cord-290004-v3ruj5bq	193	104	conserved	conserve	VBN
cord-290004-v3ruj5bq	193	105	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	193	106	stalk	stalk	NN
cord-290004-v3ruj5bq	193	107	and	and	CC
cord-290004-v3ruj5bq	193	108	conserved	conserve	VBN
cord-290004-v3ruj5bq	193	109	sites	site	NNS
cord-290004-v3ruj5bq	193	110	in	in	IN
cord-290004-v3ruj5bq	193	111	the	the	DT
cord-290004-v3ruj5bq	193	112	head	head	NN
cord-290004-v3ruj5bq	193	113	domain	domain	NN
cord-290004-v3ruj5bq	193	114	Production	production	NN
cord-290004-v3ruj5bq	193	115	and	and	CC
cord-290004-v3ruj5bq	193	116	stabilization	stabilization	NN
cord-290004-v3ruj5bq	193	117	of	of	IN
cord-290004-v3ruj5bq	193	118	the	the	DT
cord-290004-v3ruj5bq	193	119	trimeric	trimeric	NNP
cord-290004-v3ruj5bq	193	120	influenza	influenza	NN
cord-290004-v3ruj5bq	193	121	hemagglutinin	hemagglutinin	NNP
cord-290004-v3ruj5bq	193	122	stem	stem	VBP
cord-290004-v3ruj5bq	193	123	domain	domain	NN
cord-290004-v3ruj5bq	193	124	for	for	IN
cord-290004-v3ruj5bq	193	125	potentially	potentially	RB
cord-290004-v3ruj5bq	193	126	broadly	broadly	RB
cord-290004-v3ruj5bq	193	127	protective	protective	JJ
cord-290004-v3ruj5bq	193	128	influenza	influenza	NN
cord-290004-v3ruj5bq	193	129	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	194	1	A	a	DT
cord-290004-v3ruj5bq	194	2	stable	stable	JJ
cord-290004-v3ruj5bq	194	3	trimeric	trimeric	NNP
cord-290004-v3ruj5bq	194	4	influenza	influenza	NN
cord-290004-v3ruj5bq	194	5	hemagglutinin	hemagglutinin	NNP
cord-290004-v3ruj5bq	194	6	stem	stem	VBP
cord-290004-v3ruj5bq	194	7	as	as	IN
cord-290004-v3ruj5bq	194	8	a	a	DT
cord-290004-v3ruj5bq	194	9	broadly	broadly	RB
cord-290004-v3ruj5bq	194	10	protective	protective	JJ
cord-290004-v3ruj5bq	194	11	immunogen	immunogen	NN
cord-290004-v3ruj5bq	194	12	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	194	13	virus	virus	NN
cord-290004-v3ruj5bq	194	14	vaccine	vaccine	NN
cord-290004-v3ruj5bq	194	15	based	base	VBN
cord-290004-v3ruj5bq	194	16	on	on	IN
cord-290004-v3ruj5bq	194	17	the	the	DT
cord-290004-v3ruj5bq	194	18	conserved	conserve	VBN
cord-290004-v3ruj5bq	194	19	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	194	20	stalk	stalk	NN
cord-290004-v3ruj5bq	194	21	domain	domain	NN
cord-290004-v3ruj5bq	194	22	Mini	mini	NN
cord-290004-v3ruj5bq	194	23	-	-	JJ
cord-290004-v3ruj5bq	194	24	hemagglutinin	hemagglutinin	JJ
cord-290004-v3ruj5bq	194	25	vaccination	vaccination	NN
cord-290004-v3ruj5bq	195	1	induces	induce	VBZ
cord-290004-v3ruj5bq	195	2	cross	cross	JJ
cord-290004-v3ruj5bq	195	3	-	-	JJ
cord-290004-v3ruj5bq	195	4	reactive	reactive	JJ
cord-290004-v3ruj5bq	195	5	antibodies	antibody	NNS
cord-290004-v3ruj5bq	195	6	in	in	IN
cord-290004-v3ruj5bq	195	7	pre	pre	JJ
cord-290004-v3ruj5bq	195	8	-	-	JJ
cord-290004-v3ruj5bq	195	9	exposed	expose	VBN
cord-290004-v3ruj5bq	195	10	NHP	NHP	NNP
cord-290004-v3ruj5bq	195	11	that	that	WDT
cord-290004-v3ruj5bq	195	12	protect	protect	VBP
cord-290004-v3ruj5bq	195	13	mice	mouse	NNS
cord-290004-v3ruj5bq	195	14	against	against	IN
cord-290004-v3ruj5bq	195	15	lethal	lethal	JJ
cord-290004-v3ruj5bq	195	16	influenza	influenza	NN
cord-290004-v3ruj5bq	195	17	challenge	challenge	NN
cord-290004-v3ruj5bq	195	18	Hemagglutinin	Hemagglutinin	NNP
cord-290004-v3ruj5bq	195	19	-	-	HYPH
cord-290004-v3ruj5bq	195	20	stem	stem	NN
cord-290004-v3ruj5bq	195	21	nanoparticles	nanoparticle	NNS
cord-290004-v3ruj5bq	195	22	generate	generate	VBP
cord-290004-v3ruj5bq	195	23	heterosubtypic	heterosubtypic	JJ
cord-290004-v3ruj5bq	195	24	influenza	influenza	NN
cord-290004-v3ruj5bq	195	25	protection	protection	NN
cord-290004-v3ruj5bq	195	26	Immunogenicity	Immunogenicity	NNP
cord-290004-v3ruj5bq	195	27	of	of	IN
cord-290004-v3ruj5bq	195	28	chimeric	chimeric	JJ
cord-290004-v3ruj5bq	195	29	haemagglutinin	haemagglutinin	NNP
cord-290004-v3ruj5bq	195	30	-	-	HYPH
cord-290004-v3ruj5bq	195	31	based	base	VBN
cord-290004-v3ruj5bq	195	32	,	,	,
cord-290004-v3ruj5bq	195	33	universal	universal	JJ
cord-290004-v3ruj5bq	195	34	influenza	influenza	NNP
cord-290004-v3ruj5bq	195	35	virus	virus	NN
cord-290004-v3ruj5bq	195	36	vaccine	vaccine	NN
cord-290004-v3ruj5bq	195	37	candidates	candidate	NNS
cord-290004-v3ruj5bq	195	38	:	:	:
cord-290004-v3ruj5bq	196	1	Interim	interim	JJ
cord-290004-v3ruj5bq	196	2	results	result	NNS
cord-290004-v3ruj5bq	196	3	of	of	IN
cord-290004-v3ruj5bq	196	4	a	a	DT
cord-290004-v3ruj5bq	196	5	randomised	randomised	JJ
cord-290004-v3ruj5bq	196	6	,	,	,
cord-290004-v3ruj5bq	196	7	placebo	placebo	NN
cord-290004-v3ruj5bq	196	8	-	-	HYPH
cord-290004-v3ruj5bq	196	9	controlled	control	VBN
cord-290004-v3ruj5bq	196	10	,	,	,
cord-290004-v3ruj5bq	196	11	phase	phase	NN
cord-290004-v3ruj5bq	196	12	1	1	CD
cord-290004-v3ruj5bq	196	13	clinical	clinical	JJ
cord-290004-v3ruj5bq	196	14	trial	trial	NN
cord-290004-v3ruj5bq	196	15	Cross	cross	NN
cord-290004-v3ruj5bq	196	16	-	-	NN
cord-290004-v3ruj5bq	196	17	neutralization	neutralization	NN
cord-290004-v3ruj5bq	196	18	of	of	IN
cord-290004-v3ruj5bq	196	19	influenza	influenza	NN
cord-290004-v3ruj5bq	196	20	A	a	NN
cord-290004-v3ruj5bq	196	21	viruses	virus	NNS
cord-290004-v3ruj5bq	196	22	mediated	mediate	VBN
cord-290004-v3ruj5bq	196	23	by	by	IN
cord-290004-v3ruj5bq	196	24	a	a	DT
cord-290004-v3ruj5bq	196	25	single	single	JJ
cord-290004-v3ruj5bq	196	26	antibody	antibody	NN
cord-290004-v3ruj5bq	196	27	loop	loop	NN
cord-290004-v3ruj5bq	196	28	Receptor	Receptor	NNP
cord-290004-v3ruj5bq	196	29	mimicry	mimicry	NN
cord-290004-v3ruj5bq	196	30	by	by	IN
cord-290004-v3ruj5bq	196	31	antibody	antibody	NN
cord-290004-v3ruj5bq	196	32	F045	F045	NNP
cord-290004-v3ruj5bq	196	33	-	-	HYPH
cord-290004-v3ruj5bq	196	34	092	092	NNP
cord-290004-v3ruj5bq	196	35	facilitates	facilitate	VBZ
cord-290004-v3ruj5bq	196	36	universal	universal	JJ
cord-290004-v3ruj5bq	196	37	binding	binding	NN
cord-290004-v3ruj5bq	196	38	to	to	IN
cord-290004-v3ruj5bq	196	39	the	the	DT
cord-290004-v3ruj5bq	196	40	H3	H3	NNP
cord-290004-v3ruj5bq	196	41	subtype	subtype	NN
cord-290004-v3ruj5bq	196	42	of	of	IN
cord-290004-v3ruj5bq	196	43	influenza	influenza	NN
cord-290004-v3ruj5bq	196	44	virus	virus	NN
cord-290004-v3ruj5bq	196	45	Heterosubtypic	Heterosubtypic	NNP
cord-290004-v3ruj5bq	196	46	antibody	antibody	NN
cord-290004-v3ruj5bq	196	47	recognition	recognition	NN
cord-290004-v3ruj5bq	196	48	of	of	IN
cord-290004-v3ruj5bq	196	49	the	the	DT
cord-290004-v3ruj5bq	196	50	influenza	influenza	NN
cord-290004-v3ruj5bq	196	51	virus	virus	NN
cord-290004-v3ruj5bq	196	52	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	196	53	receptor	receptor	NN
cord-290004-v3ruj5bq	196	54	binding	bind	VBG
cord-290004-v3ruj5bq	196	55	site	site	NN
cord-290004-v3ruj5bq	196	56	enhanced	enhance	VBN
cord-290004-v3ruj5bq	196	57	by	by	IN
cord-290004-v3ruj5bq	196	58	avidity	avidity	NN
cord-290004-v3ruj5bq	196	59	Design	design	NN
cord-290004-v3ruj5bq	196	60	and	and	CC
cord-290004-v3ruj5bq	196	61	characterization	characterization	NN
cord-290004-v3ruj5bq	196	62	of	of	IN
cord-290004-v3ruj5bq	196	63	a	a	DT
cord-290004-v3ruj5bq	196	64	computationally	computationally	RB
cord-290004-v3ruj5bq	196	65	optimized	optimize	VBN
cord-290004-v3ruj5bq	196	66	broadly	broadly	RB
cord-290004-v3ruj5bq	196	67	reactive	reactive	JJ
cord-290004-v3ruj5bq	196	68	hemagglutinin	hemagglutinin	NNS
cord-290004-v3ruj5bq	196	69	vaccine	vaccine	NN
cord-290004-v3ruj5bq	196	70	for	for	IN
cord-290004-v3ruj5bq	196	71	H1N1	H1N1	NNP
cord-290004-v3ruj5bq	196	72	influenza	influenza	NN
cord-290004-v3ruj5bq	196	73	viruses	virus	NNS
cord-290004-v3ruj5bq	197	1	A	a	DT
cord-290004-v3ruj5bq	197	2	computationally	computationally	RB
cord-290004-v3ruj5bq	197	3	optimized	optimize	VBN
cord-290004-v3ruj5bq	197	4	broadly	broadly	RB
cord-290004-v3ruj5bq	197	5	reactive	reactive	JJ
cord-290004-v3ruj5bq	197	6	antigen	antigen	NN
cord-290004-v3ruj5bq	197	7	(	(	-LRB-
cord-290004-v3ruj5bq	197	8	COBRA	COBRA	NNP
cord-290004-v3ruj5bq	197	9	)	)	-RRB-
cord-290004-v3ruj5bq	197	10	based	base	VBN
cord-290004-v3ruj5bq	197	11	H5N1	H5N1	NNP
cord-290004-v3ruj5bq	197	12	VLP	VLP	NNP
cord-290004-v3ruj5bq	197	13	vaccine	vaccine	NN
cord-290004-v3ruj5bq	197	14	elicits	elicit	VBZ
cord-290004-v3ruj5bq	197	15	broadly	broadly	RB
cord-290004-v3ruj5bq	197	16	reactive	reactive	JJ
cord-290004-v3ruj5bq	197	17	antibodies	antibody	NNS
cord-290004-v3ruj5bq	197	18	in	in	IN
cord-290004-v3ruj5bq	197	19	mice	mouse	NNS
cord-290004-v3ruj5bq	197	20	and	and	CC
cord-290004-v3ruj5bq	197	21	ferrets	ferret	NNS
cord-290004-v3ruj5bq	198	1	A	a	DT
cord-290004-v3ruj5bq	198	2	computationally	computationally	RB
cord-290004-v3ruj5bq	198	3	optimized	optimize	VBN
cord-290004-v3ruj5bq	198	4	broadly	broadly	RB
cord-290004-v3ruj5bq	198	5	reactive	reactive	JJ
cord-290004-v3ruj5bq	198	6	antigen	antigen	NN
cord-290004-v3ruj5bq	198	7	subtype	subtype	NN
cord-290004-v3ruj5bq	198	8	-	-	HYPH
cord-290004-v3ruj5bq	198	9	specific	specific	JJ
cord-290004-v3ruj5bq	198	10	influenza	influenza	NN
cord-290004-v3ruj5bq	198	11	vaccine	vaccine	NN
cord-290004-v3ruj5bq	198	12	strategy	strategy	NN
cord-290004-v3ruj5bq	198	13	elicits	elicit	VBZ
cord-290004-v3ruj5bq	198	14	unique	unique	JJ
cord-290004-v3ruj5bq	198	15	potent	potent	JJ
cord-290004-v3ruj5bq	198	16	broadly	broadly	RB
cord-290004-v3ruj5bq	198	17	neutralizing	neutralize	VBG
cord-290004-v3ruj5bq	198	18	antibodies	antibody	NNS
cord-290004-v3ruj5bq	198	19	against	against	IN
cord-290004-v3ruj5bq	198	20	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	199	1	Purified	purify	VBN
cord-290004-v3ruj5bq	199	2	influenza	influenza	NN
cord-290004-v3ruj5bq	199	3	A	a	DT
cord-290004-v3ruj5bq	199	4	virus	virus	NN
cord-290004-v3ruj5bq	199	5	N2	n2	NN
cord-290004-v3ruj5bq	199	6	neuraminidase	neuraminidase	NN
cord-290004-v3ruj5bq	199	7	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	8	is	be	VBZ
cord-290004-v3ruj5bq	199	9	immunogenic	immunogenic	JJ
cord-290004-v3ruj5bq	199	10	and	and	CC
cord-290004-v3ruj5bq	199	11	non	non	JJ
cord-290004-v3ruj5bq	199	12	-	-	JJ
cord-290004-v3ruj5bq	199	13	toxic	toxic	JJ
cord-290004-v3ruj5bq	199	14	in	in	IN
cord-290004-v3ruj5bq	199	15	humans	human	NNS
cord-290004-v3ruj5bq	199	16	Vaccination	Vaccination	NNP
cord-290004-v3ruj5bq	199	17	with	with	IN
cord-290004-v3ruj5bq	199	18	adjuvanted	adjuvante	VBN
cord-290004-v3ruj5bq	199	19	recombinant	recombinant	NN
cord-290004-v3ruj5bq	199	20	neuraminidase	neuraminidase	NN
cord-290004-v3ruj5bq	199	21	induces	induce	VBZ
cord-290004-v3ruj5bq	199	22	broad	broad	JJ
cord-290004-v3ruj5bq	199	23	heterologous	heterologous	NNP
cord-290004-v3ruj5bq	199	24	,	,	,
cord-290004-v3ruj5bq	199	25	but	but	CC
cord-290004-v3ruj5bq	199	26	not	not	RB
cord-290004-v3ruj5bq	199	27	heterosubtypic	heterosubtypic	NNP
cord-290004-v3ruj5bq	199	28	,	,	,
cord-290004-v3ruj5bq	199	29	cross	cross	NN
cord-290004-v3ruj5bq	199	30	-	-	NN
cord-290004-v3ruj5bq	199	31	protection	protection	NN
cord-290004-v3ruj5bq	199	32	against	against	IN
cord-290004-v3ruj5bq	199	33	influenza	influenza	NN
cord-290004-v3ruj5bq	199	34	virus	virus	NN
cord-290004-v3ruj5bq	199	35	infection	infection	NN
cord-290004-v3ruj5bq	199	36	in	in	IN
cord-290004-v3ruj5bq	199	37	mice	mouse	NNS
cord-290004-v3ruj5bq	199	38	Vaccination	vaccination	NN
cord-290004-v3ruj5bq	199	39	with	with	IN
cord-290004-v3ruj5bq	199	40	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	199	41	parainfluenza	parainfluenza	NNP
cord-290004-v3ruj5bq	199	42	virus	virus	NNP
cord-290004-v3ruj5bq	199	43	5	5	CD
cord-290004-v3ruj5bq	199	44	expressing	express	VBG
cord-290004-v3ruj5bq	199	45	neuraminidase	neuraminidase	NN
cord-290004-v3ruj5bq	199	46	protects	protect	VBZ
cord-290004-v3ruj5bq	199	47	against	against	IN
cord-290004-v3ruj5bq	199	48	homologous	homologous	JJ
cord-290004-v3ruj5bq	199	49	and	and	CC
cord-290004-v3ruj5bq	199	50	heterologous	heterologous	JJ
cord-290004-v3ruj5bq	199	51	influenza	influenza	NN
cord-290004-v3ruj5bq	199	52	virus	virus	NN
cord-290004-v3ruj5bq	199	53	challenge	challenge	NN
cord-290004-v3ruj5bq	199	54	Immunogenicity	Immunogenicity	NNP
cord-290004-v3ruj5bq	199	55	and	and	CC
cord-290004-v3ruj5bq	199	56	protection	protection	NN
cord-290004-v3ruj5bq	199	57	against	against	IN
cord-290004-v3ruj5bq	199	58	influenza	influenza	NN
cord-290004-v3ruj5bq	199	59	H7N3	H7N3	NNP
cord-290004-v3ruj5bq	199	60	in	in	IN
cord-290004-v3ruj5bq	199	61	mice	mouse	NNS
cord-290004-v3ruj5bq	199	62	by	by	IN
cord-290004-v3ruj5bq	199	63	modified	modify	VBN
cord-290004-v3ruj5bq	199	64	vaccinia	vaccinia	NN
cord-290004-v3ruj5bq	199	65	virus	virus	NN
cord-290004-v3ruj5bq	199	66	Ankara	Ankara	NNP
cord-290004-v3ruj5bq	199	67	vectors	vector	NNS
cord-290004-v3ruj5bq	199	68	expressing	express	VBG
cord-290004-v3ruj5bq	199	69	influenza	influenza	NN
cord-290004-v3ruj5bq	199	70	virus	virus	NN
cord-290004-v3ruj5bq	199	71	hemagglutinin	hemagglutinin	NN
cord-290004-v3ruj5bq	199	72	or	or	CC
cord-290004-v3ruj5bq	199	73	neuraminidase	neuraminidase	NN
cord-290004-v3ruj5bq	199	74	Neuraminidase	Neuraminidase	NNP
cord-290004-v3ruj5bq	199	75	expressing	express	VBG
cord-290004-v3ruj5bq	199	76	virus	virus	NN
cord-290004-v3ruj5bq	199	77	-	-	HYPH
cord-290004-v3ruj5bq	199	78	like	like	JJ
cord-290004-v3ruj5bq	199	79	particle	particle	NN
cord-290004-v3ruj5bq	199	80	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	81	provides	provide	VBZ
cord-290004-v3ruj5bq	199	82	effective	effective	JJ
cord-290004-v3ruj5bq	199	83	cross	cross	NN
cord-290004-v3ruj5bq	199	84	protection	protection	NN
cord-290004-v3ruj5bq	199	85	against	against	IN
cord-290004-v3ruj5bq	199	86	influenza	influenza	NN
cord-290004-v3ruj5bq	199	87	virus	virus	NN
cord-290004-v3ruj5bq	199	88	M2e	m2e	NN
cord-290004-v3ruj5bq	199	89	-	-	HYPH
cord-290004-v3ruj5bq	199	90	based	base	VBN
cord-290004-v3ruj5bq	199	91	universal	universal	JJ
cord-290004-v3ruj5bq	199	92	influenza	influenza	NN
cord-290004-v3ruj5bq	199	93	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	199	94	:	:	:
cord-290004-v3ruj5bq	199	95	A	a	DT
cord-290004-v3ruj5bq	199	96	historical	historical	JJ
cord-290004-v3ruj5bq	199	97	overview	overview	NN
cord-290004-v3ruj5bq	199	98	and	and	CC
cord-290004-v3ruj5bq	199	99	new	new	JJ
cord-290004-v3ruj5bq	199	100	approaches	approach	NNS
cord-290004-v3ruj5bq	199	101	to	to	IN
cord-290004-v3ruj5bq	199	102	development	development	NN
cord-290004-v3ruj5bq	199	103	Immunopotentiation	Immunopotentiation	NNP
cord-290004-v3ruj5bq	199	104	of	of	IN
cord-290004-v3ruj5bq	199	105	trivalent	trivalent	JJ
cord-290004-v3ruj5bq	199	106	influenza	influenza	NN
cord-290004-v3ruj5bq	199	107	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	108	when	when	WRB
cord-290004-v3ruj5bq	199	109	given	give	VBN
cord-290004-v3ruj5bq	199	110	with	with	IN
cord-290004-v3ruj5bq	199	111	VAX102	VAX102	NNPS
cord-290004-v3ruj5bq	199	112	,	,	,
cord-290004-v3ruj5bq	199	113	a	a	DT
cord-290004-v3ruj5bq	199	114	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	199	115	influenza	influenza	NN
cord-290004-v3ruj5bq	199	116	M2e	M2e	VBG
cord-290004-v3ruj5bq	199	117	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	118	fused	fuse	VBD
cord-290004-v3ruj5bq	199	119	to	to	IN
cord-290004-v3ruj5bq	199	120	the	the	DT
cord-290004-v3ruj5bq	199	121	TLR5	TLR5	NNP
cord-290004-v3ruj5bq	199	122	ligand	ligand	NN
cord-290004-v3ruj5bq	199	123	flagellin	flagellin	NNP
cord-290004-v3ruj5bq	199	124	Safety	safety	NN
cord-290004-v3ruj5bq	199	125	and	and	CC
cord-290004-v3ruj5bq	199	126	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	199	127	of	of	IN
cord-290004-v3ruj5bq	199	128	a	a	DT
cord-290004-v3ruj5bq	199	129	recombinant	recombinant	JJ
cord-290004-v3ruj5bq	199	130	M2e	m2e	NN
cord-290004-v3ruj5bq	199	131	-	-	HYPH
cord-290004-v3ruj5bq	199	132	flagellin	flagellin	JJ
cord-290004-v3ruj5bq	199	133	influenza	influenza	NN
cord-290004-v3ruj5bq	199	134	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	135	(	(	-LRB-
cord-290004-v3ruj5bq	199	136	STF2	STF2	NNP
cord-290004-v3ruj5bq	199	137	.	.	.
cord-290004-v3ruj5bq	199	138	4xM2e	4xm2e	CD
cord-290004-v3ruj5bq	199	139	)	)	-RRB-
cord-290004-v3ruj5bq	199	140	in	in	IN
cord-290004-v3ruj5bq	199	141	healthy	healthy	JJ
cord-290004-v3ruj5bq	199	142	adults	adult	NNS
cord-290004-v3ruj5bq	199	143	Enhancing	enhance	VBG
cord-290004-v3ruj5bq	199	144	the	the	DT
cord-290004-v3ruj5bq	199	145	cross	cross	JJ
cord-290004-v3ruj5bq	199	146	protective	protective	JJ
cord-290004-v3ruj5bq	199	147	efficacy	efficacy	NN
cord-290004-v3ruj5bq	199	148	of	of	IN
cord-290004-v3ruj5bq	199	149	live	live	JJ
cord-290004-v3ruj5bq	199	150	attenuated	attenuated	JJ
cord-290004-v3ruj5bq	199	151	influenza	influenza	NN
cord-290004-v3ruj5bq	199	152	virus	virus	NN
cord-290004-v3ruj5bq	199	153	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	154	by	by	IN
cord-290004-v3ruj5bq	199	155	supplemented	supplement	VBN
cord-290004-v3ruj5bq	199	156	vaccination	vaccination	NN
cord-290004-v3ruj5bq	199	157	with	with	IN
cord-290004-v3ruj5bq	199	158	M2	M2	NNP
cord-290004-v3ruj5bq	199	159	ectodomain	ectodomain	NNP
cord-290004-v3ruj5bq	199	160	virus	virus	NN
cord-290004-v3ruj5bq	199	161	-	-	HYPH
cord-290004-v3ruj5bq	199	162	like	like	JJ
cord-290004-v3ruj5bq	199	163	particles	particle	NNS
cord-290004-v3ruj5bq	199	164	Influenza	Influenza	NNP
cord-290004-v3ruj5bq	199	165	M2	M2	NNP
cord-290004-v3ruj5bq	199	166	virus	virus	NN
cord-290004-v3ruj5bq	199	167	-	-	HYPH
cord-290004-v3ruj5bq	199	168	like	like	JJ
cord-290004-v3ruj5bq	199	169	particle	particle	NN
cord-290004-v3ruj5bq	199	170	vaccination	vaccination	NN
cord-290004-v3ruj5bq	199	171	enhances	enhance	VBZ
cord-290004-v3ruj5bq	199	172	protection	protection	NN
cord-290004-v3ruj5bq	199	173	in	in	IN
cord-290004-v3ruj5bq	199	174	combination	combination	NN
cord-290004-v3ruj5bq	199	175	with	with	IN
cord-290004-v3ruj5bq	199	176	avian	avian	JJ
cord-290004-v3ruj5bq	199	177	influenza	influenza	NN
cord-290004-v3ruj5bq	199	178	HA	HA	NNP
cord-290004-v3ruj5bq	199	179	VLPs	VLPs	NNP
cord-290004-v3ruj5bq	199	180	Safety	safety	NN
cord-290004-v3ruj5bq	199	181	and	and	CC
cord-290004-v3ruj5bq	199	182	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	199	183	of	of	IN
cord-290004-v3ruj5bq	199	184	multimeric-001-A	multimeric-001-a	CD
cord-290004-v3ruj5bq	199	185	novel	novel	JJ
cord-290004-v3ruj5bq	199	186	universal	universal	JJ
cord-290004-v3ruj5bq	199	187	influenza	influenza	NN
cord-290004-v3ruj5bq	199	188	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	189	AT	at	IN
cord-290004-v3ruj5bq	199	190	cell	cell	NN
cord-290004-v3ruj5bq	199	191	-	-	HYPH
cord-290004-v3ruj5bq	199	192	inducing	induce	VBG
cord-290004-v3ruj5bq	199	193	influenza	influenza	JJ
cord-290004-v3ruj5bq	199	194	vaccine	vaccine	NN
cord-290004-v3ruj5bq	199	195	for	for	IN
cord-290004-v3ruj5bq	199	196	the	the	DT
cord-290004-v3ruj5bq	199	197	elderly	elderly	JJ
cord-290004-v3ruj5bq	199	198	:	:	:
cord-290004-v3ruj5bq	199	199	Safety	safety	NN
cord-290004-v3ruj5bq	199	200	and	and	CC
cord-290004-v3ruj5bq	199	201	immunogenicity	immunogenicity	NN
cord-290004-v3ruj5bq	199	202	of	of	IN
cord-290004-v3ruj5bq	199	203	MVA	MVA	NNP
cord-290004-v3ruj5bq	199	204	-	-	HYPH
cord-290004-v3ruj5bq	199	205	NP+	NP+	NNP
cord-290004-v3ruj5bq	199	206	M1	M1	NNP
cord-290004-v3ruj5bq	199	207	in	in	IN
cord-290004-v3ruj5bq	199	208	adults	adult	NNS
cord-290004-v3ruj5bq	199	209	aged	age	VBN
cord-290004-v3ruj5bq	199	210	over	over	IN
cord-290004-v3ruj5bq	199	211	50	50	CD
cord-290004-v3ruj5bq	199	212	years	year	NNS
cord-290004-v3ruj5bq	200	1	CRTAM	CRTAM	NNP
cord-290004-v3ruj5bq	200	2	determines	determine	VBZ
cord-290004-v3ruj5bq	200	3	the	the	DT
cord-290004-v3ruj5bq	200	4	CD4	CD4	NNP
cord-290004-v3ruj5bq	200	5	+	+	CC
cord-290004-v3ruj5bq	200	6	cytotoxic	cytotoxic	JJ
cord-290004-v3ruj5bq	200	7	T	T	NNP
cord-290004-v3ruj5bq	200	8	lymphocyte	lymphocyte	NN
cord-290004-v3ruj5bq	200	9	lineage	lineage	NN
cord-290004-v3ruj5bq	200	10	NKG2C	nkg2c	NN
cord-290004-v3ruj5bq	200	11	/	/	SYM
cord-290004-v3ruj5bq	200	12	E	e	NN
cord-290004-v3ruj5bq	200	13	marks	mark	VBZ
cord-290004-v3ruj5bq	200	14	the	the	DT
cord-290004-v3ruj5bq	200	15	unique	unique	JJ
cord-290004-v3ruj5bq	200	16	cytotoxic	cytotoxic	JJ
cord-290004-v3ruj5bq	200	17	CD4	CD4	NNP
cord-290004-v3ruj5bq	200	18	T	T	NNP
cord-290004-v3ruj5bq	200	19	cell	cell	NN
cord-290004-v3ruj5bq	200	20	subset	subset	NN
cord-290004-v3ruj5bq	200	21	,	,	,
cord-290004-v3ruj5bq	200	22	ThCTL	ThCTL	NNP
cord-290004-v3ruj5bq	200	23	,	,	,
cord-290004-v3ruj5bq	200	24	generated	generate	VBN
cord-290004-v3ruj5bq	200	25	by	by	IN
cord-290004-v3ruj5bq	200	26	influenza	influenza	NN
cord-290004-v3ruj5bq	200	27	infection	infection	NN
cord-290004-v3ruj5bq	200	28	Protective	protective	JJ
cord-290004-v3ruj5bq	200	29	heterologous	heterologous	JJ
cord-290004-v3ruj5bq	200	30	antiviral	antiviral	JJ
cord-290004-v3ruj5bq	200	31	immunity	immunity	NN
cord-290004-v3ruj5bq	200	32	and	and	CC
cord-290004-v3ruj5bq	200	33	enhanced	enhanced	JJ
cord-290004-v3ruj5bq	200	34	immunopathogenesis	immunopathogenesis	NN
cord-290004-v3ruj5bq	200	35	mediated	mediate	VBN
cord-290004-v3ruj5bq	200	36	by	by	IN
cord-290004-v3ruj5bq	200	37	memory	memory	NN
cord-290004-v3ruj5bq	200	38	T	T	NNP
cord-290004-v3ruj5bq	200	39	cell	cell	NN
cord-290004-v3ruj5bq	200	40	populations	population	NNS
cord-290004-v3ruj5bq	200	41	Memory	Memory	NNP
cord-290004-v3ruj5bq	200	42	CD8	CD8	NNP
cord-290004-v3ruj5bq	200	43	T	T	NNP
cord-290004-v3ruj5bq	200	44	cells	cell	NNS
cord-290004-v3ruj5bq	200	45	mediate	mediate	VBP
cord-290004-v3ruj5bq	200	46	severe	severe	JJ
cord-290004-v3ruj5bq	200	47	immunopathology	immunopathology	NN
cord-290004-v3ruj5bq	200	48	following	follow	VBG
cord-290004-v3ruj5bq	200	49	respiratory	respiratory	JJ
cord-290004-v3ruj5bq	200	50	syncytial	syncytial	JJ
cord-290004-v3ruj5bq	200	51	virus	virus	NN
cord-290004-v3ruj5bq	200	52	infection	infection	NN
cord-290004-v3ruj5bq	200	53	T	T	NNP
cord-290004-v3ruj5bq	200	54	cell	cell	NN
cord-290004-v3ruj5bq	200	55	immunodominance	immunodominance	NN
cord-290004-v3ruj5bq	200	56	and	and	CC
cord-290004-v3ruj5bq	200	57	maintenance	maintenance	NN
cord-290004-v3ruj5bq	200	58	of	of	IN
cord-290004-v3ruj5bq	200	59	memory	memory	NN
cord-290004-v3ruj5bq	200	60	regulated	regulate	VBN
cord-290004-v3ruj5bq	200	61	by	by	IN
cord-290004-v3ruj5bq	200	62	unexpectedly	unexpectedly	RB
cord-290004-v3ruj5bq	200	63	cross	cross	JJ
cord-290004-v3ruj5bq	200	64	-	-	JJ
cord-290004-v3ruj5bq	200	65	reactive	reactive	JJ
cord-290004-v3ruj5bq	200	66	pathogens	pathogen	NNS
cord-290004-v3ruj5bq	200	67	Past	past	IN
cord-290004-v3ruj5bq	200	68	life	life	NN
cord-290004-v3ruj5bq	200	69	and	and	CC
cord-290004-v3ruj5bq	200	70	future	future	JJ
cord-290004-v3ruj5bq	200	71	effects	effect	NNS
cord-290004-v3ruj5bq	201	1	-How	-how	IN
cord-290004-v3ruj5bq	201	2	heterologous	heterologous	JJ
cord-290004-v3ruj5bq	201	3	infections	infection	NNS
cord-290004-v3ruj5bq	201	4	alter	alter	VBP
cord-290004-v3ruj5bq	201	5	immunity	immunity	NN
cord-290004-v3ruj5bq	201	6	to	to	IN
cord-290004-v3ruj5bq	201	7	influenza	influenza	NN
cord-290004-v3ruj5bq	201	8	viruses	virus	NNS
cord-290004-v3ruj5bq	201	9	Workshop	Workshop	NNP
cord-290004-v3ruj5bq	201	10	report	report	NN
cord-290004-v3ruj5bq	201	11	:	:	:
cord-290004-v3ruj5bq	201	12	Experimental	experimental	JJ
cord-290004-v3ruj5bq	201	13	animal	animal	NN
cord-290004-v3ruj5bq	201	14	models	model	NNS
cord-290004-v3ruj5bq	201	15	for	for	IN
cord-290004-v3ruj5bq	201	16	universal	universal	JJ
cord-290004-v3ruj5bq	201	17	influenza	influenza	NN
cord-290004-v3ruj5bq	201	18	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	201	19	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	201	20	:	:	:
cord-290004-v3ruj5bq	201	21	Status	status	NN
cord-290004-v3ruj5bq	201	22	report	report	NN
cord-290004-v3ruj5bq	201	23	.	.	.
cord-290004-v3ruj5bq	202	1	Immunity	Immunity	NNP
cord-290004-v3ruj5bq	202	2	Immunogenicity	Immunogenicity	NNP
cord-290004-v3ruj5bq	202	3	of	of	IN
cord-290004-v3ruj5bq	202	4	an	an	DT
cord-290004-v3ruj5bq	202	5	adenoviral	adenoviral	NN
cord-290004-v3ruj5bq	202	6	-	-	HYPH
cord-290004-v3ruj5bq	202	7	based	base	VBN
cord-290004-v3ruj5bq	202	8	Middle	Middle	NNP
cord-290004-v3ruj5bq	202	9	East	East	NNP
cord-290004-v3ruj5bq	202	10	Respiratory	Respiratory	NNP
cord-290004-v3ruj5bq	202	11	Syndrome	Syndrome	NNP
cord-290004-v3ruj5bq	202	12	coronavirus	coronavirus	NN
cord-290004-v3ruj5bq	202	13	vaccine	vaccine	NN
cord-290004-v3ruj5bq	202	14	in	in	IN
cord-290004-v3ruj5bq	202	15	BALB	BALB	NNP
cord-290004-v3ruj5bq	202	16	/	/	SYM
cord-290004-v3ruj5bq	202	17	c	c	NN
cord-290004-v3ruj5bq	202	18	mice	mouse	NNS
cord-290004-v3ruj5bq	202	19	Systemic	systemic	JJ
cord-290004-v3ruj5bq	202	20	and	and	CC
cord-290004-v3ruj5bq	202	21	mucosal	mucosal	JJ
cord-290004-v3ruj5bq	202	22	immunity	immunity	NN
cord-290004-v3ruj5bq	202	23	in	in	IN
cord-290004-v3ruj5bq	202	24	mice	mouse	NNS
cord-290004-v3ruj5bq	202	25	elicited	elicit	VBN
cord-290004-v3ruj5bq	202	26	by	by	IN
cord-290004-v3ruj5bq	202	27	a	a	DT
cord-290004-v3ruj5bq	202	28	single	single	JJ
cord-290004-v3ruj5bq	202	29	immunization	immunization	NN
cord-290004-v3ruj5bq	202	30	with	with	IN
cord-290004-v3ruj5bq	202	31	human	human	JJ
cord-290004-v3ruj5bq	202	32	adenovirus	adenovirus	NN
cord-290004-v3ruj5bq	202	33	type	type	NN
cord-290004-v3ruj5bq	202	34	5	5	CD
cord-290004-v3ruj5bq	202	35	or	or	CC
cord-290004-v3ruj5bq	202	36	41	41	CD
cord-290004-v3ruj5bq	202	37	vector	vector	NN
cord-290004-v3ruj5bq	202	38	-	-	HYPH
cord-290004-v3ruj5bq	202	39	based	base	VBN
cord-290004-v3ruj5bq	202	40	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	202	41	carrying	carry	VBG
cord-290004-v3ruj5bq	202	42	the	the	DT
cord-290004-v3ruj5bq	202	43	spike	spike	NN
cord-290004-v3ruj5bq	202	44	protein	protein	NN
cord-290004-v3ruj5bq	202	45	of	of	IN
cord-290004-v3ruj5bq	202	46	Middle	Middle	NNP
cord-290004-v3ruj5bq	202	47	East	East	NNP
cord-290004-v3ruj5bq	203	1	respiratory	respiratory	JJ
cord-290004-v3ruj5bq	203	2	syndrome	syndrome	NN
cord-290004-v3ruj5bq	203	3	coronavirus	coronavirus	NN
cord-290004-v3ruj5bq	204	1	Recent	recent	JJ
cord-290004-v3ruj5bq	204	2	advances	advance	NNS
cord-290004-v3ruj5bq	204	3	in	in	IN
cord-290004-v3ruj5bq	204	4	the	the	DT
cord-290004-v3ruj5bq	204	5	vaccine	vaccine	NN
cord-290004-v3ruj5bq	204	6	development	development	NN
cord-290004-v3ruj5bq	204	7	against	against	IN
cord-290004-v3ruj5bq	204	8	Middle	Middle	NNP
cord-290004-v3ruj5bq	204	9	East	East	NNP
cord-290004-v3ruj5bq	204	10	respiratory	respiratory	JJ
cord-290004-v3ruj5bq	204	11	syndrome	syndrome	NN
cord-290004-v3ruj5bq	204	12	-	-	HYPH
cord-290004-v3ruj5bq	204	13	coronavirus	coronavirus	NN
cord-290004-v3ruj5bq	204	14	Improving	improve	VBG
cord-290004-v3ruj5bq	204	15	influenza	influenza	NN
cord-290004-v3ruj5bq	204	16	vaccines	vaccine	NNS
cord-290004-v3ruj5bq	204	17	:	:	:
cord-290004-v3ruj5bq	204	18	Challenges	challenge	NNS
cord-290004-v3ruj5bq	204	19	to	to	IN
cord-290004-v3ruj5bq	204	20	effective	effective	JJ
cord-290004-v3ruj5bq	204	21	implementation	implementation	NN
cord-290004-v3ruj5bq	205	1	The	the	DT
cord-290004-v3ruj5bq	205	2	authors	author	NNS
cord-290004-v3ruj5bq	205	3	declare	declare	VBP
cord-290004-v3ruj5bq	205	4	no	no	DT
cord-290004-v3ruj5bq	205	5	conflict	conflict	NN
cord-290004-v3ruj5bq	205	6	of	of	IN
cord-290004-v3ruj5bq	205	7	interest	interest	NN
cord-290004-v3ruj5bq	205	8	.	.	.