id sid tid token lemma pos cord-325325-xw7627x9 1 1 key key NNP cord-325325-xw7627x9 1 2 : : : cord-325325-xw7627x9 1 3 cord-325325-xw7627x9 cord-325325-xw7627x9 NNS cord-325325-xw7627x9 1 4 authors author NNS cord-325325-xw7627x9 1 5 : : : cord-325325-xw7627x9 1 6 Skeik Skeik NNP cord-325325-xw7627x9 1 7 , , , cord-325325-xw7627x9 1 8 Nedaa Nedaa NNP cord-325325-xw7627x9 1 9 ; ; : cord-325325-xw7627x9 1 10 Jabr Jabr NNP cord-325325-xw7627x9 1 11 , , , cord-325325-xw7627x9 1 12 Fadi Fadi NNP cord-325325-xw7627x9 1 13 I. I. NNP cord-325325-xw7627x9 1 14 title title NN cord-325325-xw7627x9 1 15 : : : cord-325325-xw7627x9 1 16 Influenza influenza NN cord-325325-xw7627x9 1 17 viruses virus NNS cord-325325-xw7627x9 1 18 and and CC cord-325325-xw7627x9 1 19 the the DT cord-325325-xw7627x9 1 20 evolution evolution NN cord-325325-xw7627x9 1 21 of of IN cord-325325-xw7627x9 1 22 avian avian JJ cord-325325-xw7627x9 1 23 influenza influenza NN cord-325325-xw7627x9 1 24 virus virus NN cord-325325-xw7627x9 1 25 H5N1 H5N1 NNP cord-325325-xw7627x9 1 26 date date NN cord-325325-xw7627x9 1 27 : : : cord-325325-xw7627x9 1 28 2007 2007 CD cord-325325-xw7627x9 1 29 - - SYM cord-325325-xw7627x9 1 30 10 10 CD cord-325325-xw7627x9 1 31 - - SYM cord-325325-xw7627x9 1 32 02 02 CD cord-325325-xw7627x9 1 33 journal journal NN cord-325325-xw7627x9 1 34 : : : cord-325325-xw7627x9 2 1 Int Int NNP cord-325325-xw7627x9 2 2 J J NNP cord-325325-xw7627x9 2 3 Infect infect VB cord-325325-xw7627x9 2 4 Dis Dis NNP cord-325325-xw7627x9 2 5 DOI doi NN cord-325325-xw7627x9 2 6 : : : cord-325325-xw7627x9 2 7 10.1016 10.1016 CD cord-325325-xw7627x9 2 8 / / SYM cord-325325-xw7627x9 2 9 j.ijid.2007.07.002 j.ijid.2007.07.002 . cord-325325-xw7627x9 3 1 sha sha NNP cord-325325-xw7627x9 3 2 : : : cord-325325-xw7627x9 3 3 89b2443eb035af348d3702963fe3100eb803bb17 89b2443eb035af348d3702963fe3100eb803bb17 CD cord-325325-xw7627x9 3 4 doc_id doc_id CD cord-325325-xw7627x9 3 5 : : : cord-325325-xw7627x9 4 1 325325 325325 CD cord-325325-xw7627x9 4 2 cord_uid cord_uid NN cord-325325-xw7627x9 4 3 : : : cord-325325-xw7627x9 5 1 xw7627x9 xw7627x9 NNP cord-325325-xw7627x9 5 2 Although although IN cord-325325-xw7627x9 5 3 small small JJ cord-325325-xw7627x9 5 4 in in IN cord-325325-xw7627x9 5 5 size size NN cord-325325-xw7627x9 5 6 and and CC cord-325325-xw7627x9 5 7 simple simple JJ cord-325325-xw7627x9 5 8 in in IN cord-325325-xw7627x9 5 9 structure structure NN cord-325325-xw7627x9 5 10 , , , cord-325325-xw7627x9 5 11 influenza influenza NN cord-325325-xw7627x9 5 12 viruses virus NNS cord-325325-xw7627x9 5 13 are be VBP cord-325325-xw7627x9 5 14 sophisticated sophisticated JJ cord-325325-xw7627x9 5 15 organisms organism NNS cord-325325-xw7627x9 5 16 with with IN cord-325325-xw7627x9 5 17 highly highly RB cord-325325-xw7627x9 5 18 mutagenic mutagenic JJ cord-325325-xw7627x9 5 19 genomes genome NNS cord-325325-xw7627x9 5 20 and and CC cord-325325-xw7627x9 5 21 wide wide JJ cord-325325-xw7627x9 5 22 antigenic antigenic JJ cord-325325-xw7627x9 5 23 diversity diversity NN cord-325325-xw7627x9 5 24 . . . cord-325325-xw7627x9 6 1 They -PRON- PRP cord-325325-xw7627x9 6 2 are be VBP cord-325325-xw7627x9 6 3 species species NN cord-325325-xw7627x9 6 4 - - HYPH cord-325325-xw7627x9 6 5 specific specific JJ cord-325325-xw7627x9 6 6 organisms organism NNS cord-325325-xw7627x9 6 7 . . . cord-325325-xw7627x9 7 1 Mutation mutation NN cord-325325-xw7627x9 7 2 and and CC cord-325325-xw7627x9 7 3 reassortment reassortment NN cord-325325-xw7627x9 7 4 have have VBP cord-325325-xw7627x9 7 5 resulted result VBN cord-325325-xw7627x9 7 6 in in IN cord-325325-xw7627x9 7 7 newer new JJR cord-325325-xw7627x9 7 8 viruses virus NNS cord-325325-xw7627x9 7 9 such such JJ cord-325325-xw7627x9 7 10 as as IN cord-325325-xw7627x9 7 11 H5N1 H5N1 NNP cord-325325-xw7627x9 7 12 , , , cord-325325-xw7627x9 7 13 with with IN cord-325325-xw7627x9 7 14 new new JJ cord-325325-xw7627x9 7 15 resistance resistance NN cord-325325-xw7627x9 7 16 against against IN cord-325325-xw7627x9 7 17 anti anti JJ cord-325325-xw7627x9 7 18 - - JJ cord-325325-xw7627x9 7 19 viral viral JJ cord-325325-xw7627x9 7 20 medications medication NNS cord-325325-xw7627x9 7 21 , , , cord-325325-xw7627x9 7 22 and and CC cord-325325-xw7627x9 7 23 this this DT cord-325325-xw7627x9 7 24 might may MD cord-325325-xw7627x9 7 25 lead lead VB cord-325325-xw7627x9 7 26 to to IN cord-325325-xw7627x9 7 27 the the DT cord-325325-xw7627x9 7 28 emergence emergence NN cord-325325-xw7627x9 7 29 of of IN cord-325325-xw7627x9 7 30 a a DT cord-325325-xw7627x9 7 31 fully fully RB cord-325325-xw7627x9 7 32 transmissible transmissible JJ cord-325325-xw7627x9 7 33 strain strain NN cord-325325-xw7627x9 7 34 , , , cord-325325-xw7627x9 7 35 as as IN cord-325325-xw7627x9 7 36 occurred occur VBD cord-325325-xw7627x9 7 37 in in IN cord-325325-xw7627x9 7 38 the the DT cord-325325-xw7627x9 7 39 1957 1957 CD cord-325325-xw7627x9 7 40 and and CC cord-325325-xw7627x9 7 41 1968 1968 CD cord-325325-xw7627x9 7 42 pandemics pandemic NNS cord-325325-xw7627x9 7 43 . . . cord-325325-xw7627x9 8 1 Influenza influenza NN cord-325325-xw7627x9 8 2 viruses virus NNS cord-325325-xw7627x9 8 3 are be VBP cord-325325-xw7627x9 8 4 no no RB cord-325325-xw7627x9 8 5 longer long RBR cord-325325-xw7627x9 8 6 just just RB cord-325325-xw7627x9 8 7 a a DT cord-325325-xw7627x9 8 8 cause cause NN cord-325325-xw7627x9 8 9 of of IN cord-325325-xw7627x9 8 10 self self NN cord-325325-xw7627x9 8 11 - - HYPH cord-325325-xw7627x9 8 12 limited limit VBN cord-325325-xw7627x9 8 13 upper upper JJ cord-325325-xw7627x9 8 14 respiratory respiratory JJ cord-325325-xw7627x9 8 15 tract tract NN cord-325325-xw7627x9 8 16 infections infection NNS cord-325325-xw7627x9 8 17 ; ; : cord-325325-xw7627x9 8 18 the the DT cord-325325-xw7627x9 8 19 H5N1 H5N1 NNP cord-325325-xw7627x9 8 20 avian avian JJ cord-325325-xw7627x9 8 21 influenza influenza NN cord-325325-xw7627x9 8 22 virus virus NN cord-325325-xw7627x9 8 23 can can MD cord-325325-xw7627x9 8 24 cause cause VB cord-325325-xw7627x9 8 25 severe severe JJ cord-325325-xw7627x9 8 26 human human JJ cord-325325-xw7627x9 8 27 infection infection NN cord-325325-xw7627x9 8 28 with with IN cord-325325-xw7627x9 8 29 a a DT cord-325325-xw7627x9 8 30 mortality mortality NN cord-325325-xw7627x9 8 31 rate rate NN cord-325325-xw7627x9 8 32 exceeding exceed VBG cord-325325-xw7627x9 8 33 50 50 CD cord-325325-xw7627x9 8 34 % % NN cord-325325-xw7627x9 8 35 . . . cord-325325-xw7627x9 9 1 The the DT cord-325325-xw7627x9 9 2 case case NN cord-325325-xw7627x9 9 3 death death NN cord-325325-xw7627x9 9 4 rate rate NN cord-325325-xw7627x9 9 5 of of IN cord-325325-xw7627x9 9 6 H5N1 H5N1 NNP cord-325325-xw7627x9 9 7 avian avian JJ cord-325325-xw7627x9 9 8 influenza influenza NN cord-325325-xw7627x9 9 9 infection infection NN cord-325325-xw7627x9 9 10 is be VBZ cord-325325-xw7627x9 9 11 20 20 CD cord-325325-xw7627x9 9 12 times time NNS cord-325325-xw7627x9 9 13 higher high JJR cord-325325-xw7627x9 9 14 than than IN cord-325325-xw7627x9 9 15 that that DT cord-325325-xw7627x9 9 16 of of IN cord-325325-xw7627x9 9 17 the the DT cord-325325-xw7627x9 9 18 1918 1918 CD cord-325325-xw7627x9 9 19 infection infection NN cord-325325-xw7627x9 9 20 ( ( -LRB- cord-325325-xw7627x9 9 21 50 50 CD cord-325325-xw7627x9 9 22 % % NN cord-325325-xw7627x9 9 23 versus versus IN cord-325325-xw7627x9 9 24 2.5 2.5 CD cord-325325-xw7627x9 9 25 % % NN cord-325325-xw7627x9 9 26 ) ) -RRB- cord-325325-xw7627x9 9 27 , , , cord-325325-xw7627x9 9 28 which which WDT cord-325325-xw7627x9 9 29 killed kill VBD cord-325325-xw7627x9 9 30 675 675 CD cord-325325-xw7627x9 9 31 000 000 CD cord-325325-xw7627x9 9 32 people people NNS cord-325325-xw7627x9 9 33 in in IN cord-325325-xw7627x9 9 34 the the DT cord-325325-xw7627x9 9 35 USA USA NNP cord-325325-xw7627x9 9 36 and and CC cord-325325-xw7627x9 9 37 almost almost RB cord-325325-xw7627x9 9 38 40 40 CD cord-325325-xw7627x9 9 39 million million CD cord-325325-xw7627x9 9 40 people people NNS cord-325325-xw7627x9 9 41 worldwide worldwide RB cord-325325-xw7627x9 9 42 . . . cord-325325-xw7627x9 10 1 While while IN cord-325325-xw7627x9 10 2 the the DT cord-325325-xw7627x9 10 3 clock clock NN cord-325325-xw7627x9 10 4 is be VBZ cord-325325-xw7627x9 10 5 still still RB cord-325325-xw7627x9 10 6 ticking tick VBG cord-325325-xw7627x9 10 7 towards towards IN cord-325325-xw7627x9 10 8 what what WP cord-325325-xw7627x9 10 9 seems seem VBZ cord-325325-xw7627x9 10 10 to to TO cord-325325-xw7627x9 10 11 be be VB cord-325325-xw7627x9 10 12 inevitable inevitable JJ cord-325325-xw7627x9 10 13 pandemic pandemic NN cord-325325-xw7627x9 10 14 influenza influenza NN cord-325325-xw7627x9 10 15 , , , cord-325325-xw7627x9 10 16 on on IN cord-325325-xw7627x9 10 17 April April NNP cord-325325-xw7627x9 10 18 17 17 CD cord-325325-xw7627x9 10 19 , , , cord-325325-xw7627x9 10 20 2007 2007 CD cord-325325-xw7627x9 10 21 the the DT cord-325325-xw7627x9 10 22 U.S. U.S. NNP cord-325325-xw7627x9 10 23 Food Food NNP cord-325325-xw7627x9 10 24 and and CC cord-325325-xw7627x9 10 25 Drug Drug NNP cord-325325-xw7627x9 10 26 Administration Administration NNP cord-325325-xw7627x9 10 27 ( ( -LRB- cord-325325-xw7627x9 10 28 FDA FDA NNP cord-325325-xw7627x9 10 29 ) ) -RRB- cord-325325-xw7627x9 10 30 approved approve VBD cord-325325-xw7627x9 10 31 the the DT cord-325325-xw7627x9 10 32 first first JJ cord-325325-xw7627x9 10 33 vaccine vaccine NN cord-325325-xw7627x9 10 34 against against IN cord-325325-xw7627x9 10 35 the the DT cord-325325-xw7627x9 10 36 avian avian JJ cord-325325-xw7627x9 10 37 influenza influenza NN cord-325325-xw7627x9 10 38 virus virus NN cord-325325-xw7627x9 10 39 H5N1 H5N1 NNP cord-325325-xw7627x9 10 40 for for IN cord-325325-xw7627x9 10 41 humans human NNS cord-325325-xw7627x9 10 42 at at IN cord-325325-xw7627x9 10 43 high high JJ cord-325325-xw7627x9 10 44 risk risk NN cord-325325-xw7627x9 10 45 . . . cord-325325-xw7627x9 11 1 However however RB cord-325325-xw7627x9 11 2 , , , cord-325325-xw7627x9 11 3 more more JJR cord-325325-xw7627x9 11 4 research research NN cord-325325-xw7627x9 11 5 is be VBZ cord-325325-xw7627x9 11 6 needed need VBN cord-325325-xw7627x9 11 7 to to TO cord-325325-xw7627x9 11 8 develop develop VB cord-325325-xw7627x9 11 9 a a DT cord-325325-xw7627x9 11 10 more more RBR cord-325325-xw7627x9 11 11 effective effective JJ cord-325325-xw7627x9 11 12 and and CC cord-325325-xw7627x9 11 13 affordable affordable JJ cord-325325-xw7627x9 11 14 vaccine vaccine NN cord-325325-xw7627x9 11 15 that that WDT cord-325325-xw7627x9 11 16 can can MD cord-325325-xw7627x9 11 17 be be VB cord-325325-xw7627x9 11 18 given give VBN cord-325325-xw7627x9 11 19 at at IN cord-325325-xw7627x9 11 20 lower low JJR cord-325325-xw7627x9 11 21 doses dose NNS cord-325325-xw7627x9 11 22 . . . cord-325325-xw7627x9 12 1 Summary summary NN cord-325325-xw7627x9 13 1 Although although IN cord-325325-xw7627x9 13 2 small small JJ cord-325325-xw7627x9 13 3 in in IN cord-325325-xw7627x9 13 4 size size NN cord-325325-xw7627x9 13 5 and and CC cord-325325-xw7627x9 13 6 simple simple JJ cord-325325-xw7627x9 13 7 in in IN cord-325325-xw7627x9 13 8 structure structure NN cord-325325-xw7627x9 13 9 , , , cord-325325-xw7627x9 13 10 influenza influenza NN cord-325325-xw7627x9 13 11 viruses virus NNS cord-325325-xw7627x9 13 12 are be VBP cord-325325-xw7627x9 13 13 sophisticated sophisticated JJ cord-325325-xw7627x9 13 14 organisms organism NNS cord-325325-xw7627x9 13 15 with with IN cord-325325-xw7627x9 13 16 highly highly RB cord-325325-xw7627x9 13 17 mutagenic mutagenic JJ cord-325325-xw7627x9 13 18 genomes genome NNS cord-325325-xw7627x9 13 19 and and CC cord-325325-xw7627x9 13 20 wide wide JJ cord-325325-xw7627x9 13 21 antigenic antigenic JJ cord-325325-xw7627x9 13 22 diversity diversity NN cord-325325-xw7627x9 13 23 . . . cord-325325-xw7627x9 14 1 They -PRON- PRP cord-325325-xw7627x9 14 2 are be VBP cord-325325-xw7627x9 14 3 species species NN cord-325325-xw7627x9 14 4 - - HYPH cord-325325-xw7627x9 14 5 specific specific JJ cord-325325-xw7627x9 14 6 organisms organism NNS cord-325325-xw7627x9 14 7 . . . cord-325325-xw7627x9 15 1 Mutation mutation NN cord-325325-xw7627x9 15 2 and and CC cord-325325-xw7627x9 15 3 reassortment reassortment NN cord-325325-xw7627x9 15 4 have have VBP cord-325325-xw7627x9 15 5 resulted result VBN cord-325325-xw7627x9 15 6 in in IN cord-325325-xw7627x9 15 7 newer new JJR cord-325325-xw7627x9 15 8 viruses virus NNS cord-325325-xw7627x9 15 9 such such JJ cord-325325-xw7627x9 15 10 as as IN cord-325325-xw7627x9 15 11 H5N1 H5N1 NNP cord-325325-xw7627x9 15 12 , , , cord-325325-xw7627x9 15 13 with with IN cord-325325-xw7627x9 15 14 new new JJ cord-325325-xw7627x9 15 15 resistance resistance NN cord-325325-xw7627x9 15 16 against against IN cord-325325-xw7627x9 15 17 anti anti JJ cord-325325-xw7627x9 15 18 - - JJ cord-325325-xw7627x9 15 19 viral viral JJ cord-325325-xw7627x9 15 20 medications medication NNS cord-325325-xw7627x9 15 21 , , , cord-325325-xw7627x9 15 22 and and CC cord-325325-xw7627x9 15 23 this this DT cord-325325-xw7627x9 15 24 might may MD cord-325325-xw7627x9 15 25 lead lead VB cord-325325-xw7627x9 15 26 to to IN cord-325325-xw7627x9 15 27 the the DT cord-325325-xw7627x9 15 28 emergence emergence NN cord-325325-xw7627x9 15 29 of of IN cord-325325-xw7627x9 15 30 a a DT cord-325325-xw7627x9 15 31 fully fully RB cord-325325-xw7627x9 15 32 transmissible transmissible JJ cord-325325-xw7627x9 15 33 strain strain NN cord-325325-xw7627x9 15 34 , , , cord-325325-xw7627x9 15 35 as as IN cord-325325-xw7627x9 15 36 occurred occur VBD cord-325325-xw7627x9 15 37 in in IN cord-325325-xw7627x9 15 38 the the DT cord-325325-xw7627x9 15 39 1957 1957 CD cord-325325-xw7627x9 15 40 and and CC cord-325325-xw7627x9 15 41 1968 1968 CD cord-325325-xw7627x9 15 42 pandemics pandemic NNS cord-325325-xw7627x9 15 43 . . . cord-325325-xw7627x9 16 1 Influenza influenza NN cord-325325-xw7627x9 16 2 viruses virus NNS cord-325325-xw7627x9 16 3 are be VBP cord-325325-xw7627x9 16 4 no no RB cord-325325-xw7627x9 16 5 longer long RBR cord-325325-xw7627x9 16 6 just just RB cord-325325-xw7627x9 16 7 a a DT cord-325325-xw7627x9 16 8 cause cause NN cord-325325-xw7627x9 16 9 of of IN cord-325325-xw7627x9 16 10 self self NN cord-325325-xw7627x9 16 11 - - HYPH cord-325325-xw7627x9 16 12 limited limit VBN cord-325325-xw7627x9 16 13 upper upper JJ cord-325325-xw7627x9 16 14 respiratory respiratory JJ cord-325325-xw7627x9 16 15 tract tract NN cord-325325-xw7627x9 16 16 infections infection NNS cord-325325-xw7627x9 16 17 ; ; : cord-325325-xw7627x9 16 18 the the DT cord-325325-xw7627x9 16 19 H5N1 H5N1 NNP cord-325325-xw7627x9 16 20 avian avian JJ cord-325325-xw7627x9 16 21 influenza influenza NN cord-325325-xw7627x9 16 22 virus virus NN cord-325325-xw7627x9 16 23 can can MD cord-325325-xw7627x9 16 24 cause cause VB cord-325325-xw7627x9 16 25 severe severe JJ cord-325325-xw7627x9 16 26 human human JJ cord-325325-xw7627x9 16 27 infection infection NN cord-325325-xw7627x9 16 28 with with IN cord-325325-xw7627x9 16 29 a a DT cord-325325-xw7627x9 16 30 mortality mortality NN cord-325325-xw7627x9 16 31 rate rate NN cord-325325-xw7627x9 16 32 exceeding exceed VBG cord-325325-xw7627x9 16 33 50 50 CD cord-325325-xw7627x9 16 34 % % NN cord-325325-xw7627x9 16 35 . . . cord-325325-xw7627x9 17 1 The the DT cord-325325-xw7627x9 17 2 case case NN cord-325325-xw7627x9 17 3 death death NN cord-325325-xw7627x9 17 4 rate rate NN cord-325325-xw7627x9 17 5 of of IN cord-325325-xw7627x9 17 6 H5N1 H5N1 NNP cord-325325-xw7627x9 17 7 avian avian JJ cord-325325-xw7627x9 17 8 influenza influenza NN cord-325325-xw7627x9 17 9 infection infection NN cord-325325-xw7627x9 17 10 is be VBZ cord-325325-xw7627x9 17 11 20 20 CD cord-325325-xw7627x9 17 12 times time NNS cord-325325-xw7627x9 17 13 higher high JJR cord-325325-xw7627x9 17 14 than than IN cord-325325-xw7627x9 17 15 that that DT cord-325325-xw7627x9 17 16 of of IN cord-325325-xw7627x9 17 17 the the DT cord-325325-xw7627x9 17 18 1918 1918 CD cord-325325-xw7627x9 17 19 infection infection NN cord-325325-xw7627x9 17 20 ( ( -LRB- cord-325325-xw7627x9 17 21 50 50 CD cord-325325-xw7627x9 17 22 % % NN cord-325325-xw7627x9 17 23 versus versus IN cord-325325-xw7627x9 17 24 2.5 2.5 CD cord-325325-xw7627x9 17 25 % % NN cord-325325-xw7627x9 17 26 ) ) -RRB- cord-325325-xw7627x9 17 27 , , , cord-325325-xw7627x9 17 28 which which WDT cord-325325-xw7627x9 17 29 killed kill VBD cord-325325-xw7627x9 17 30 675 675 CD cord-325325-xw7627x9 17 31 000 000 CD cord-325325-xw7627x9 17 32 people people NNS cord-325325-xw7627x9 17 33 in in IN cord-325325-xw7627x9 17 34 the the DT cord-325325-xw7627x9 17 35 USA USA NNP cord-325325-xw7627x9 17 36 and and CC cord-325325-xw7627x9 17 37 almost almost RB cord-325325-xw7627x9 17 38 40 40 CD cord-325325-xw7627x9 17 39 million million CD cord-325325-xw7627x9 17 40 people people NNS cord-325325-xw7627x9 17 41 worldwide worldwide RB cord-325325-xw7627x9 17 42 . . . cord-325325-xw7627x9 18 1 While while IN cord-325325-xw7627x9 18 2 the the DT cord-325325-xw7627x9 18 3 clock clock NN cord-325325-xw7627x9 18 4 is be VBZ cord-325325-xw7627x9 18 5 still still RB cord-325325-xw7627x9 18 6 ticking tick VBG cord-325325-xw7627x9 18 7 towards towards IN cord-325325-xw7627x9 18 8 what what WP cord-325325-xw7627x9 18 9 seems seem VBZ cord-325325-xw7627x9 18 10 to to TO cord-325325-xw7627x9 18 11 be be VB cord-325325-xw7627x9 18 12 inevitable inevitable JJ cord-325325-xw7627x9 18 13 pandemic pandemic NN cord-325325-xw7627x9 18 14 influenza influenza NN cord-325325-xw7627x9 18 15 , , , cord-325325-xw7627x9 18 16 on on IN cord-325325-xw7627x9 18 17 April April NNP cord-325325-xw7627x9 18 18 17 17 CD cord-325325-xw7627x9 18 19 , , , cord-325325-xw7627x9 18 20 2007 2007 CD cord-325325-xw7627x9 18 21 the the DT cord-325325-xw7627x9 18 22 U.S. U.S. NNP cord-325325-xw7627x9 18 23 Food Food NNP cord-325325-xw7627x9 18 24 and and CC cord-325325-xw7627x9 18 25 Drug Drug NNP cord-325325-xw7627x9 18 26 Administration Administration NNP cord-325325-xw7627x9 18 27 ( ( -LRB- cord-325325-xw7627x9 18 28 FDA FDA NNP cord-325325-xw7627x9 18 29 ) ) -RRB- cord-325325-xw7627x9 18 30 approved approve VBD cord-325325-xw7627x9 18 31 the the DT cord-325325-xw7627x9 18 32 first first JJ cord-325325-xw7627x9 18 33 vaccine vaccine NN cord-325325-xw7627x9 18 34 against against IN cord-325325-xw7627x9 18 35 the the DT cord-325325-xw7627x9 18 36 avian avian JJ cord-325325-xw7627x9 18 37 influenza influenza NN cord-325325-xw7627x9 18 38 virus virus NN cord-325325-xw7627x9 18 39 H5N1 H5N1 NNP cord-325325-xw7627x9 18 40 for for IN cord-325325-xw7627x9 18 41 humans human NNS cord-325325-xw7627x9 18 42 at at IN cord-325325-xw7627x9 18 43 high high JJ cord-325325-xw7627x9 18 44 risk risk NN cord-325325-xw7627x9 18 45 . . . cord-325325-xw7627x9 19 1 However however RB cord-325325-xw7627x9 19 2 , , , cord-325325-xw7627x9 19 3 more more JJR cord-325325-xw7627x9 19 4 research research NN cord-325325-xw7627x9 19 5 is be VBZ cord-325325-xw7627x9 19 6 needed need VBN cord-325325-xw7627x9 19 7 to to TO cord-325325-xw7627x9 19 8 develop develop VB cord-325325-xw7627x9 19 9 a a DT cord-325325-xw7627x9 19 10 more more RBR cord-325325-xw7627x9 19 11 effective effective JJ cord-325325-xw7627x9 19 12 and and CC cord-325325-xw7627x9 19 13 affordable affordable JJ cord-325325-xw7627x9 19 14 vaccine vaccine NN cord-325325-xw7627x9 19 15 that that WDT cord-325325-xw7627x9 19 16 can can MD cord-325325-xw7627x9 19 17 be be VB cord-325325-xw7627x9 19 18 given give VBN cord-325325-xw7627x9 19 19 at at IN cord-325325-xw7627x9 19 20 lower low JJR cord-325325-xw7627x9 19 21 doses dose NNS cord-325325-xw7627x9 19 22 . . . cord-325325-xw7627x9 20 1 # # $ cord-325325-xw7627x9 20 2 2007 2007 CD cord-325325-xw7627x9 20 3 International International NNP cord-325325-xw7627x9 20 4 Society Society NNP cord-325325-xw7627x9 20 5 for for IN cord-325325-xw7627x9 20 6 Infectious Infectious NNP cord-325325-xw7627x9 20 7 Diseases Diseases NNPS cord-325325-xw7627x9 20 8 . . . cord-325325-xw7627x9 21 1 Published publish VBN cord-325325-xw7627x9 21 2 by by IN cord-325325-xw7627x9 22 1 Elsevier Elsevier NNP cord-325325-xw7627x9 22 2 Ltd. Ltd. NNP cord-325325-xw7627x9 22 3 All all DT cord-325325-xw7627x9 22 4 rights right NNS cord-325325-xw7627x9 22 5 reserved reserve VBN cord-325325-xw7627x9 22 6 . . . cord-325325-xw7627x9 23 1 Antigenic antigenic JJ cord-325325-xw7627x9 23 2 drift drift NN cord-325325-xw7627x9 23 3 is be VBZ cord-325325-xw7627x9 23 4 a a DT cord-325325-xw7627x9 23 5 relatively relatively RB cord-325325-xw7627x9 23 6 minor minor JJ cord-325325-xw7627x9 23 7 antigenic antigenic JJ cord-325325-xw7627x9 23 8 change change NN cord-325325-xw7627x9 23 9 that that WDT cord-325325-xw7627x9 23 10 occurs occur VBZ cord-325325-xw7627x9 23 11 frequently frequently RB cord-325325-xw7627x9 23 12 within within IN cord-325325-xw7627x9 23 13 the the DT cord-325325-xw7627x9 23 14 HA HA NNP cord-325325-xw7627x9 23 15 or or CC cord-325325-xw7627x9 23 16 NA NA NNP cord-325325-xw7627x9 23 17 of of IN cord-325325-xw7627x9 23 18 the the DT cord-325325-xw7627x9 23 19 virus virus NN cord-325325-xw7627x9 23 20 , , , cord-325325-xw7627x9 23 21 and and CC cord-325325-xw7627x9 23 22 is be VBZ cord-325325-xw7627x9 23 23 usually usually RB cord-325325-xw7627x9 23 24 responsible responsible JJ cord-325325-xw7627x9 23 25 for for IN cord-325325-xw7627x9 23 26 epidemic epidemic NN cord-325325-xw7627x9 23 27 disease disease NN cord-325325-xw7627x9 23 28 . . . cord-325325-xw7627x9 24 1 5 5 CD cord-325325-xw7627x9 24 2 , , , cord-325325-xw7627x9 24 3 6 6 CD cord-325325-xw7627x9 24 4 Antigenic antigenic JJ cord-325325-xw7627x9 24 5 shift shift NN cord-325325-xw7627x9 24 6 brings bring VBZ cord-325325-xw7627x9 24 7 up up RP cord-325325-xw7627x9 24 8 new new JJ cord-325325-xw7627x9 24 9 viruses virus NNS cord-325325-xw7627x9 24 10 with with IN cord-325325-xw7627x9 24 11 different different JJ cord-325325-xw7627x9 24 12 HA HA NNP cord-325325-xw7627x9 24 13 or or CC cord-325325-xw7627x9 24 14 NA NA NNP cord-325325-xw7627x9 24 15 antigens antigen NNS cord-325325-xw7627x9 24 16 . . . cord-325325-xw7627x9 25 1 This this DT cord-325325-xw7627x9 25 2 can can MD cord-325325-xw7627x9 25 3 be be VB cord-325325-xw7627x9 25 4 achieved achieve VBN cord-325325-xw7627x9 25 5 by by IN cord-325325-xw7627x9 25 6 mutation mutation NN cord-325325-xw7627x9 25 7 or or CC cord-325325-xw7627x9 25 8 genetic genetic JJ cord-325325-xw7627x9 25 9 reassortment reassortment NN cord-325325-xw7627x9 25 10 ( ( -LRB- cord-325325-xw7627x9 25 11 two two CD cord-325325-xw7627x9 25 12 different different JJ cord-325325-xw7627x9 25 13 influenza influenza NN cord-325325-xw7627x9 25 14 virus virus NN cord-325325-xw7627x9 25 15 strains strain NNS cord-325325-xw7627x9 25 16 swap swap VBP cord-325325-xw7627x9 25 17 their -PRON- PRP$ cord-325325-xw7627x9 25 18 genes gene NNS cord-325325-xw7627x9 25 19 giving give VBG cord-325325-xw7627x9 25 20 rise rise NN cord-325325-xw7627x9 25 21 to to IN cord-325325-xw7627x9 25 22 a a DT cord-325325-xw7627x9 25 23 hybrid hybrid JJ cord-325325-xw7627x9 25 24 strain strain NN cord-325325-xw7627x9 25 25 ) ) -RRB- cord-325325-xw7627x9 25 26 , , , cord-325325-xw7627x9 25 27 which which WDT cord-325325-xw7627x9 25 28 usually usually RB cord-325325-xw7627x9 25 29 leads lead VBZ cord-325325-xw7627x9 25 30 to to IN cord-325325-xw7627x9 25 31 pandemic pandemic NN cord-325325-xw7627x9 25 32 disease disease NN cord-325325-xw7627x9 25 33 . . . cord-325325-xw7627x9 26 1 7 7 CD cord-325325-xw7627x9 27 1 The the DT cord-325325-xw7627x9 27 2 1918 1918 CD cord-325325-xw7627x9 27 3 influenza influenza NN cord-325325-xw7627x9 27 4 pandemic pandemic NN cord-325325-xw7627x9 27 5 was be VBD cord-325325-xw7627x9 27 6 caused cause VBN cord-325325-xw7627x9 27 7 by by IN cord-325325-xw7627x9 27 8 the the DT cord-325325-xw7627x9 27 9 H1N1 H1N1 NNP cord-325325-xw7627x9 27 10 subtype subtype NN cord-325325-xw7627x9 27 11 that that WDT cord-325325-xw7627x9 27 12 mutated mutate VBD cord-325325-xw7627x9 27 13 from from IN cord-325325-xw7627x9 27 14 a a DT cord-325325-xw7627x9 27 15 purely purely RB cord-325325-xw7627x9 27 16 avian avian JJ cord-325325-xw7627x9 27 17 virus virus NN cord-325325-xw7627x9 27 18 . . . cord-325325-xw7627x9 28 1 It -PRON- PRP cord-325325-xw7627x9 28 2 was be VBD cord-325325-xw7627x9 28 3 the the DT cord-325325-xw7627x9 28 4 worst bad JJS cord-325325-xw7627x9 28 5 pandemic pandemic NN cord-325325-xw7627x9 28 6 by by IN cord-325325-xw7627x9 28 7 far far RB cord-325325-xw7627x9 28 8 . . . cord-325325-xw7627x9 29 1 It -PRON- PRP cord-325325-xw7627x9 29 2 killed kill VBD cord-325325-xw7627x9 29 3 at at RB cord-325325-xw7627x9 29 4 least least RBS cord-325325-xw7627x9 29 5 40 40 CD cord-325325-xw7627x9 29 6 million million CD cord-325325-xw7627x9 29 7 people people NNS cord-325325-xw7627x9 29 8 worldwide worldwide RB cord-325325-xw7627x9 29 9 , , , cord-325325-xw7627x9 29 10 including include VBG cord-325325-xw7627x9 29 11 675 675 CD cord-325325-xw7627x9 29 12 000 000 CD cord-325325-xw7627x9 29 13 people people NNS cord-325325-xw7627x9 29 14 in in IN cord-325325-xw7627x9 29 15 the the DT cord-325325-xw7627x9 29 16 USA USA NNP cord-325325-xw7627x9 29 17 . . . cord-325325-xw7627x9 30 1 The the DT cord-325325-xw7627x9 30 2 average average JJ cord-325325-xw7627x9 30 3 life life NN cord-325325-xw7627x9 30 4 expectancy expectancy NN cord-325325-xw7627x9 30 5 in in IN cord-325325-xw7627x9 30 6 the the DT cord-325325-xw7627x9 30 7 USA USA NNP cord-325325-xw7627x9 30 8 decreased decrease VBD cord-325325-xw7627x9 30 9 by by IN cord-325325-xw7627x9 30 10 more more JJR cord-325325-xw7627x9 30 11 than than IN cord-325325-xw7627x9 30 12 10 10 CD cord-325325-xw7627x9 30 13 years year NNS cord-325325-xw7627x9 30 14 at at IN cord-325325-xw7627x9 30 15 that that DT cord-325325-xw7627x9 30 16 time time NN cord-325325-xw7627x9 30 17 . . . cord-325325-xw7627x9 31 1 [ [ -LRB- cord-325325-xw7627x9 31 2 8 8 CD cord-325325-xw7627x9 31 3 ] ] -RRB- cord-325325-xw7627x9 31 4 [ [ -LRB- cord-325325-xw7627x9 31 5 9 9 CD cord-325325-xw7627x9 31 6 ] ] -RRB- cord-325325-xw7627x9 31 7 [ [ -LRB- cord-325325-xw7627x9 31 8 10 10 CD cord-325325-xw7627x9 31 9 ] ] -RRB- cord-325325-xw7627x9 32 1 [ [ -LRB- cord-325325-xw7627x9 32 2 11 11 CD cord-325325-xw7627x9 32 3 ] ] -RRB- cord-325325-xw7627x9 33 1 The the DT cord-325325-xw7627x9 33 2 1957 1957 CD cord-325325-xw7627x9 33 3 pandemic pandemic NN cord-325325-xw7627x9 33 4 was be VBD cord-325325-xw7627x9 33 5 caused cause VBN cord-325325-xw7627x9 33 6 by by IN cord-325325-xw7627x9 33 7 the the DT cord-325325-xw7627x9 33 8 H2N2 H2N2 NNP cord-325325-xw7627x9 33 9 subtype subtype NN cord-325325-xw7627x9 33 10 , , , cord-325325-xw7627x9 33 11 a a DT cord-325325-xw7627x9 33 12 product product NN cord-325325-xw7627x9 33 13 of of IN cord-325325-xw7627x9 33 14 genetic genetic JJ cord-325325-xw7627x9 33 15 reassortment reassortment NN cord-325325-xw7627x9 33 16 in in IN cord-325325-xw7627x9 33 17 hosts host NNS cord-325325-xw7627x9 33 18 infected infect VBN cord-325325-xw7627x9 33 19 with with IN cord-325325-xw7627x9 33 20 both both CC cord-325325-xw7627x9 33 21 an an DT cord-325325-xw7627x9 33 22 avian avian JJ cord-325325-xw7627x9 33 23 and and CC cord-325325-xw7627x9 33 24 human human JJ cord-325325-xw7627x9 33 25 influenza influenza NN cord-325325-xw7627x9 33 26 virus virus NN cord-325325-xw7627x9 33 27 . . . cord-325325-xw7627x9 34 1 It -PRON- PRP cord-325325-xw7627x9 34 2 killed kill VBD cord-325325-xw7627x9 34 3 about about RB cord-325325-xw7627x9 34 4 70 70 CD cord-325325-xw7627x9 34 5 000 000 CD cord-325325-xw7627x9 34 6 people people NNS cord-325325-xw7627x9 34 7 in in IN cord-325325-xw7627x9 34 8 the the DT cord-325325-xw7627x9 34 9 USA USA NNP cord-325325-xw7627x9 34 10 . . . cord-325325-xw7627x9 35 1 [ [ -LRB- cord-325325-xw7627x9 35 2 12 12 CD cord-325325-xw7627x9 35 3 ] ] -RRB- cord-325325-xw7627x9 35 4 [ [ -LRB- cord-325325-xw7627x9 35 5 13 13 CD cord-325325-xw7627x9 35 6 ] ] -RRB- cord-325325-xw7627x9 36 1 [ [ -LRB- cord-325325-xw7627x9 36 2 14 14 CD cord-325325-xw7627x9 36 3 ] ] -RRB- cord-325325-xw7627x9 37 1 The the DT cord-325325-xw7627x9 37 2 1968 1968 CD cord-325325-xw7627x9 37 3 pandemic pandemic NN cord-325325-xw7627x9 37 4 was be VBD cord-325325-xw7627x9 37 5 caused cause VBN cord-325325-xw7627x9 37 6 by by IN cord-325325-xw7627x9 37 7 the the DT cord-325325-xw7627x9 37 8 H3N2 H3N2 NNP cord-325325-xw7627x9 37 9 subtype subtype NN cord-325325-xw7627x9 37 10 , , , cord-325325-xw7627x9 37 11 a a DT cord-325325-xw7627x9 37 12 product product NN cord-325325-xw7627x9 37 13 of of IN cord-325325-xw7627x9 37 14 genetic genetic JJ cord-325325-xw7627x9 37 15 reassortment reassortment NN cord-325325-xw7627x9 37 16 . . . cord-325325-xw7627x9 38 1 It -PRON- PRP cord-325325-xw7627x9 38 2 killed kill VBD cord-325325-xw7627x9 38 3 approximately approximately RB cord-325325-xw7627x9 38 4 34 34 CD cord-325325-xw7627x9 38 5 000 000 CD cord-325325-xw7627x9 38 6 people people NNS cord-325325-xw7627x9 38 7 in in IN cord-325325-xw7627x9 38 8 the the DT cord-325325-xw7627x9 38 9 USA USA NNP cord-325325-xw7627x9 38 10 . . . cord-325325-xw7627x9 39 1 14 14 CD cord-325325-xw7627x9 39 2 _SP cord-325325-xw7627x9 40 1 Avian avian JJ cord-325325-xw7627x9 40 2 influenza influenza NN cord-325325-xw7627x9 40 3 is be VBZ cord-325325-xw7627x9 40 4 a a DT cord-325325-xw7627x9 40 5 contagious contagious JJ cord-325325-xw7627x9 40 6 disease disease NN cord-325325-xw7627x9 40 7 of of IN cord-325325-xw7627x9 40 8 animals animal NNS cord-325325-xw7627x9 40 9 caused cause VBN cord-325325-xw7627x9 40 10 by by IN cord-325325-xw7627x9 40 11 viruses virus NNS cord-325325-xw7627x9 40 12 that that WDT cord-325325-xw7627x9 40 13 normally normally RB cord-325325-xw7627x9 40 14 infect infect VBP cord-325325-xw7627x9 40 15 only only RB cord-325325-xw7627x9 40 16 birds bird NNS cord-325325-xw7627x9 40 17 , , , cord-325325-xw7627x9 40 18 and and CC cord-325325-xw7627x9 40 19 less less RBR cord-325325-xw7627x9 40 20 commonly commonly RB cord-325325-xw7627x9 40 21 , , , cord-325325-xw7627x9 40 22 pigs pig NNS cord-325325-xw7627x9 40 23 . . . cord-325325-xw7627x9 41 1 With with IN cord-325325-xw7627x9 41 2 the the DT cord-325325-xw7627x9 41 3 fact fact NN cord-325325-xw7627x9 41 4 that that IN cord-325325-xw7627x9 41 5 both both CC cord-325325-xw7627x9 41 6 human human JJ cord-325325-xw7627x9 41 7 and and CC cord-325325-xw7627x9 41 8 mammalian mammalian JJ cord-325325-xw7627x9 41 9 receptors receptor NNS cord-325325-xw7627x9 41 10 are be VBP cord-325325-xw7627x9 41 11 present present JJ cord-325325-xw7627x9 41 12 in in IN cord-325325-xw7627x9 41 13 different different JJ cord-325325-xw7627x9 41 14 proportions proportion NNS cord-325325-xw7627x9 41 15 in in IN cord-325325-xw7627x9 41 16 tissues tissue NNS cord-325325-xw7627x9 41 17 of of IN cord-325325-xw7627x9 41 18 both both DT cord-325325-xw7627x9 41 19 species specie NNS cord-325325-xw7627x9 41 20 , , , cord-325325-xw7627x9 41 21 the the DT cord-325325-xw7627x9 41 22 bird bird NN cord-325325-xw7627x9 41 23 influenza influenza NN cord-325325-xw7627x9 41 24 virus virus NN cord-325325-xw7627x9 41 25 may may MD cord-325325-xw7627x9 41 26 infect infect VB cord-325325-xw7627x9 41 27 humans human NNS cord-325325-xw7627x9 41 28 . . . cord-325325-xw7627x9 42 1 When when WRB cord-325325-xw7627x9 42 2 mutations mutation NNS cord-325325-xw7627x9 42 3 or or CC cord-325325-xw7627x9 42 4 reassortments reassortment NNS cord-325325-xw7627x9 42 5 occur occur VBP cord-325325-xw7627x9 42 6 , , , cord-325325-xw7627x9 42 7 this this DT cord-325325-xw7627x9 42 8 could could MD cord-325325-xw7627x9 42 9 lead lead VB cord-325325-xw7627x9 42 10 to to IN cord-325325-xw7627x9 42 11 the the DT cord-325325-xw7627x9 42 12 emergence emergence NN cord-325325-xw7627x9 42 13 of of IN cord-325325-xw7627x9 42 14 a a DT cord-325325-xw7627x9 42 15 fully fully RB cord-325325-xw7627x9 42 16 transmissible transmissible JJ cord-325325-xw7627x9 42 17 strain strain NN cord-325325-xw7627x9 42 18 , , , cord-325325-xw7627x9 42 19 as as IN cord-325325-xw7627x9 42 20 in in IN cord-325325-xw7627x9 42 21 the the DT cord-325325-xw7627x9 42 22 1957 1957 CD cord-325325-xw7627x9 42 23 and and CC cord-325325-xw7627x9 42 24 1968 1968 CD cord-325325-xw7627x9 42 25 pandemics pandemic NNS cord-325325-xw7627x9 42 26 . . . cord-325325-xw7627x9 43 1 Finally finally RB cord-325325-xw7627x9 43 2 , , , cord-325325-xw7627x9 43 3 they -PRON- PRP cord-325325-xw7627x9 43 4 can can MD cord-325325-xw7627x9 43 5 transmit transmit VB cord-325325-xw7627x9 43 6 not not RB cord-325325-xw7627x9 43 7 only only RB cord-325325-xw7627x9 43 8 to to IN cord-325325-xw7627x9 43 9 humans human NNS cord-325325-xw7627x9 43 10 but but CC cord-325325-xw7627x9 43 11 also also RB cord-325325-xw7627x9 43 12 to to IN cord-325325-xw7627x9 43 13 other other JJ cord-325325-xw7627x9 43 14 mammals mammal NNS cord-325325-xw7627x9 43 15 . . . cord-325325-xw7627x9 44 1 15 15 CD cord-325325-xw7627x9 45 1 In in IN cord-325325-xw7627x9 45 2 birds bird NNS cord-325325-xw7627x9 45 3 , , , cord-325325-xw7627x9 45 4 the the DT cord-325325-xw7627x9 45 5 low low JJ cord-325325-xw7627x9 45 6 pathogenic pathogenic JJ cord-325325-xw7627x9 45 7 form form NN cord-325325-xw7627x9 45 8 causes cause VBZ cord-325325-xw7627x9 45 9 only only RB cord-325325-xw7627x9 45 10 mild mild JJ cord-325325-xw7627x9 45 11 symptoms symptom NNS cord-325325-xw7627x9 45 12 such such JJ cord-325325-xw7627x9 45 13 as as IN cord-325325-xw7627x9 45 14 decreased decrease VBN cord-325325-xw7627x9 45 15 egg egg NN cord-325325-xw7627x9 45 16 production production NN cord-325325-xw7627x9 45 17 . . . cord-325325-xw7627x9 46 1 The the DT cord-325325-xw7627x9 46 2 high high JJ cord-325325-xw7627x9 46 3 pathogenic pathogenic JJ cord-325325-xw7627x9 46 4 form form NN cord-325325-xw7627x9 46 5 can can MD cord-325325-xw7627x9 46 6 affect affect VB cord-325325-xw7627x9 46 7 multiple multiple JJ cord-325325-xw7627x9 46 8 organs organ NNS cord-325325-xw7627x9 46 9 and and CC cord-325325-xw7627x9 46 10 the the DT cord-325325-xw7627x9 46 11 mortality mortality NN cord-325325-xw7627x9 46 12 rate rate NN cord-325325-xw7627x9 46 13 can can MD cord-325325-xw7627x9 46 14 reach reach VB cord-325325-xw7627x9 46 15 100 100 CD cord-325325-xw7627x9 46 16 % % NN cord-325325-xw7627x9 46 17 , , , cord-325325-xw7627x9 46 18 often often RB cord-325325-xw7627x9 46 19 within within IN cord-325325-xw7627x9 46 20 48 48 CD cord-325325-xw7627x9 46 21 hours hour NNS cord-325325-xw7627x9 46 22 . . . cord-325325-xw7627x9 47 1 The the DT cord-325325-xw7627x9 47 2 presence presence NN cord-325325-xw7627x9 47 3 or or CC cord-325325-xw7627x9 47 4 absence absence NN cord-325325-xw7627x9 47 5 of of IN cord-325325-xw7627x9 47 6 symptoms symptom NNS cord-325325-xw7627x9 47 7 and and CC cord-325325-xw7627x9 47 8 their -PRON- PRP$ cord-325325-xw7627x9 47 9 severity severity NN cord-325325-xw7627x9 47 10 caused cause VBN cord-325325-xw7627x9 47 11 by by IN cord-325325-xw7627x9 47 12 low low JJ cord-325325-xw7627x9 47 13 pathogenic pathogenic JJ cord-325325-xw7627x9 47 14 viruses virus NNS cord-325325-xw7627x9 47 15 depend depend VBP cord-325325-xw7627x9 47 16 on on IN cord-325325-xw7627x9 47 17 the the DT cord-325325-xw7627x9 47 18 type type NN cord-325325-xw7627x9 47 19 of of IN cord-325325-xw7627x9 47 20 bird bird NN cord-325325-xw7627x9 47 21 species specie NNS cord-325325-xw7627x9 47 22 affected affect VBN cord-325325-xw7627x9 47 23 . . . cord-325325-xw7627x9 48 1 The the DT cord-325325-xw7627x9 48 2 same same JJ cord-325325-xw7627x9 48 3 holds hold VBZ cord-325325-xw7627x9 48 4 for for IN cord-325325-xw7627x9 48 5 the the DT cord-325325-xw7627x9 48 6 highly highly RB cord-325325-xw7627x9 48 7 pathogenic pathogenic JJ cord-325325-xw7627x9 48 8 ones one NNS cord-325325-xw7627x9 48 9 : : : cord-325325-xw7627x9 48 10 in in IN cord-325325-xw7627x9 48 11 wild wild JJ cord-325325-xw7627x9 48 12 and and CC cord-325325-xw7627x9 48 13 domestic domestic JJ cord-325325-xw7627x9 48 14 ducks duck NNS cord-325325-xw7627x9 48 15 they -PRON- PRP cord-325325-xw7627x9 48 16 can can MD cord-325325-xw7627x9 48 17 be be VB cord-325325-xw7627x9 48 18 asymptomatic asymptomatic JJ cord-325325-xw7627x9 48 19 , , , cord-325325-xw7627x9 48 20 whereas whereas IN cord-325325-xw7627x9 48 21 they -PRON- PRP cord-325325-xw7627x9 48 22 are be VBP cord-325325-xw7627x9 48 23 lethal lethal JJ cord-325325-xw7627x9 48 24 in in IN cord-325325-xw7627x9 48 25 terrestrial terrestrial JJ cord-325325-xw7627x9 48 26 birds bird NNS cord-325325-xw7627x9 48 27 . . . cord-325325-xw7627x9 49 1 15 15 CD cord-325325-xw7627x9 49 2 _SP cord-325325-xw7627x9 50 1 The the DT cord-325325-xw7627x9 50 2 first first JJ cord-325325-xw7627x9 50 3 clinical clinical JJ cord-325325-xw7627x9 50 4 respiratory respiratory JJ cord-325325-xw7627x9 50 5 illness illness NN cord-325325-xw7627x9 50 6 of of IN cord-325325-xw7627x9 50 7 H5N1 H5N1 NNP cord-325325-xw7627x9 50 8 avian avian JJ cord-325325-xw7627x9 50 9 influenza influenza NN cord-325325-xw7627x9 50 10 occurred occur VBD cord-325325-xw7627x9 50 11 in in IN cord-325325-xw7627x9 50 12 Hong Hong NNP cord-325325-xw7627x9 50 13 Kong Kong NNP cord-325325-xw7627x9 50 14 in in IN cord-325325-xw7627x9 50 15 1997 1997 CD cord-325325-xw7627x9 50 16 , , , cord-325325-xw7627x9 50 17 when when WRB cord-325325-xw7627x9 50 18 18 18 CD cord-325325-xw7627x9 50 19 human human JJ cord-325325-xw7627x9 50 20 cases case NNS cord-325325-xw7627x9 50 21 were be VBD cord-325325-xw7627x9 50 22 reported report VBN cord-325325-xw7627x9 50 23 during during IN cord-325325-xw7627x9 50 24 a a DT cord-325325-xw7627x9 50 25 poultry poultry NN cord-325325-xw7627x9 50 26 outbreak outbreak NN cord-325325-xw7627x9 50 27 . . . cord-325325-xw7627x9 51 1 It -PRON- PRP cord-325325-xw7627x9 51 2 broke break VBD cord-325325-xw7627x9 51 3 the the DT cord-325325-xw7627x9 51 4 species specie NNS cord-325325-xw7627x9 51 5 barrier barrier NN cord-325325-xw7627x9 51 6 to to TO cord-325325-xw7627x9 51 7 infect infect VB cord-325325-xw7627x9 51 8 humans human NNS cord-325325-xw7627x9 51 9 , , , cord-325325-xw7627x9 51 10 cats cat NNS cord-325325-xw7627x9 51 11 , , , cord-325325-xw7627x9 51 12 and and CC cord-325325-xw7627x9 51 13 tigers tiger NNS cord-325325-xw7627x9 51 14 . . . cord-325325-xw7627x9 52 1 [ [ -LRB- cord-325325-xw7627x9 52 2 16 16 CD cord-325325-xw7627x9 52 3 ] ] -RRB- cord-325325-xw7627x9 52 4 [ [ -LRB- cord-325325-xw7627x9 52 5 17 17 CD cord-325325-xw7627x9 52 6 ] ] -RRB- cord-325325-xw7627x9 53 1 [ [ -LRB- cord-325325-xw7627x9 53 2 18 18 CD cord-325325-xw7627x9 53 3 ] ] -RRB- cord-325325-xw7627x9 54 1 So so RB cord-325325-xw7627x9 54 2 far far RB cord-325325-xw7627x9 54 3 it -PRON- PRP cord-325325-xw7627x9 54 4 has have VBZ cord-325325-xw7627x9 54 5 affected affect VBN cord-325325-xw7627x9 54 6 many many JJ cord-325325-xw7627x9 54 7 countries country NNS cord-325325-xw7627x9 54 8 in in IN cord-325325-xw7627x9 54 9 Asia Asia NNP cord-325325-xw7627x9 54 10 , , , cord-325325-xw7627x9 54 11 Africa Africa NNP cord-325325-xw7627x9 54 12 , , , cord-325325-xw7627x9 54 13 and and CC cord-325325-xw7627x9 54 14 Europe Europe NNP cord-325325-xw7627x9 54 15 . . . cord-325325-xw7627x9 55 1 According accord VBG cord-325325-xw7627x9 55 2 to to IN cord-325325-xw7627x9 55 3 the the DT cord-325325-xw7627x9 55 4 cases case NNS cord-325325-xw7627x9 55 5 reported report VBN cord-325325-xw7627x9 55 6 to to IN cord-325325-xw7627x9 55 7 The the DT cord-325325-xw7627x9 55 8 World World NNP cord-325325-xw7627x9 55 9 Health Health NNP cord-325325-xw7627x9 55 10 Organization Organization NNP cord-325325-xw7627x9 55 11 ( ( -LRB- cord-325325-xw7627x9 55 12 WHO who WP cord-325325-xw7627x9 55 13 ) ) -RRB- cord-325325-xw7627x9 55 14 appearing appear VBG cord-325325-xw7627x9 55 15 on on IN cord-325325-xw7627x9 55 16 the the DT cord-325325-xw7627x9 55 17 WHO WHO NNP cord-325325-xw7627x9 55 18 website website NN cord-325325-xw7627x9 55 19 on on IN cord-325325-xw7627x9 55 20 June June NNP cord-325325-xw7627x9 55 21 29 29 CD cord-325325-xw7627x9 55 22 , , , cord-325325-xw7627x9 55 23 2007 2007 CD cord-325325-xw7627x9 55 24 , , , cord-325325-xw7627x9 55 25 the the DT cord-325325-xw7627x9 55 26 H5N1 H5N1 NNP cord-325325-xw7627x9 55 27 virus virus NN cord-325325-xw7627x9 55 28 has have VBZ cord-325325-xw7627x9 55 29 already already RB cord-325325-xw7627x9 55 30 infected infect VBN cord-325325-xw7627x9 55 31 317 317 CD cord-325325-xw7627x9 55 32 humans human NNS cord-325325-xw7627x9 55 33 and and CC cord-325325-xw7627x9 55 34 has have VBZ cord-325325-xw7627x9 55 35 killed kill VBN cord-325325-xw7627x9 55 36 191 191 CD cord-325325-xw7627x9 55 37 patients patient NNS cord-325325-xw7627x9 55 38 worldwide worldwide RB cord-325325-xw7627x9 55 39 , , , cord-325325-xw7627x9 55 40 with with IN cord-325325-xw7627x9 55 41 a a DT cord-325325-xw7627x9 55 42 mortality mortality NN cord-325325-xw7627x9 55 43 rate rate NN cord-325325-xw7627x9 55 44 exceeding exceed VBG cord-325325-xw7627x9 55 45 50 50 CD cord-325325-xw7627x9 55 46 % % NN cord-325325-xw7627x9 55 47 . . . cord-325325-xw7627x9 56 1 19 19 CD cord-325325-xw7627x9 56 2 Avian avian JJ cord-325325-xw7627x9 56 3 influenza influenza NN cord-325325-xw7627x9 56 4 H5N1 H5N1 NNP cord-325325-xw7627x9 56 5 also also RB cord-325325-xw7627x9 56 6 affects affect VBZ cord-325325-xw7627x9 56 7 domesticated domesticate VBN cord-325325-xw7627x9 56 8 poultry poultry NN cord-325325-xw7627x9 56 9 , , , cord-325325-xw7627x9 56 10 including include VBG cord-325325-xw7627x9 56 11 chickens chicken NNS cord-325325-xw7627x9 56 12 , , , cord-325325-xw7627x9 56 13 ducks duck NNS cord-325325-xw7627x9 56 14 , , , cord-325325-xw7627x9 56 15 and and CC cord-325325-xw7627x9 56 16 turkeys turkey NNS cord-325325-xw7627x9 56 17 . . . cord-325325-xw7627x9 57 1 The the DT cord-325325-xw7627x9 57 2 contribution contribution NN cord-325325-xw7627x9 57 3 of of IN cord-325325-xw7627x9 57 4 migratory migratory JJ cord-325325-xw7627x9 57 5 birds bird NNS cord-325325-xw7627x9 57 6 like like IN cord-325325-xw7627x9 57 7 wild wild JJ cord-325325-xw7627x9 57 8 ducks duck NNS cord-325325-xw7627x9 57 9 , , , cord-325325-xw7627x9 57 10 geese goose NNS cord-325325-xw7627x9 57 11 , , , cord-325325-xw7627x9 57 12 swans swan NNS cord-325325-xw7627x9 57 13 , , , cord-325325-xw7627x9 57 14 and and CC cord-325325-xw7627x9 57 15 hawks hawk NNS cord-325325-xw7627x9 57 16 ( ( -LRB- cord-325325-xw7627x9 57 17 Saudi Saudi NNP cord-325325-xw7627x9 57 18 Arabia Arabia NNP cord-325325-xw7627x9 57 19 ) ) -RRB- cord-325325-xw7627x9 57 20 to to IN cord-325325-xw7627x9 57 21 the the DT cord-325325-xw7627x9 57 22 spread spread NN cord-325325-xw7627x9 57 23 of of IN cord-325325-xw7627x9 57 24 the the DT cord-325325-xw7627x9 57 25 H5N1 H5N1 NNP cord-325325-xw7627x9 57 26 virus virus NN cord-325325-xw7627x9 57 27 from from IN cord-325325-xw7627x9 57 28 Asia Asia NNP cord-325325-xw7627x9 57 29 to to IN cord-325325-xw7627x9 57 30 Europe Europe NNP cord-325325-xw7627x9 57 31 and and CC cord-325325-xw7627x9 57 32 Africa Africa NNP cord-325325-xw7627x9 57 33 is be VBZ cord-325325-xw7627x9 57 34 still still RB cord-325325-xw7627x9 57 35 controversial controversial JJ cord-325325-xw7627x9 57 36 , , , cord-325325-xw7627x9 57 37 since since IN cord-325325-xw7627x9 57 38 basically basically RB cord-325325-xw7627x9 57 39 all all DT cord-325325-xw7627x9 57 40 wild wild JJ cord-325325-xw7627x9 57 41 birds bird NNS cord-325325-xw7627x9 57 42 positive positive JJ cord-325325-xw7627x9 57 43 for for IN cord-325325-xw7627x9 57 44 H5N1 H5N1 NNP cord-325325-xw7627x9 57 45 virus virus NN cord-325325-xw7627x9 57 46 have have VBP cord-325325-xw7627x9 57 47 been be VBN cord-325325-xw7627x9 57 48 found find VBN cord-325325-xw7627x9 57 49 dead dead JJ cord-325325-xw7627x9 57 50 or or CC cord-325325-xw7627x9 57 51 very very RB cord-325325-xw7627x9 57 52 sick sick JJ cord-325325-xw7627x9 57 53 , , , cord-325325-xw7627x9 57 54 thus thus RB cord-325325-xw7627x9 57 55 unlikely unlikely JJ cord-325325-xw7627x9 57 56 to to TO cord-325325-xw7627x9 57 57 have have VB cord-325325-xw7627x9 57 58 been be VBN cord-325325-xw7627x9 57 59 able able JJ cord-325325-xw7627x9 57 60 to to TO cord-325325-xw7627x9 57 61 fly fly VB cord-325325-xw7627x9 57 62 over over IN cord-325325-xw7627x9 57 63 long long JJ cord-325325-xw7627x9 57 64 distances distance NNS cord-325325-xw7627x9 57 65 . . . cord-325325-xw7627x9 58 1 At at IN cord-325325-xw7627x9 58 2 the the DT cord-325325-xw7627x9 58 3 same same JJ cord-325325-xw7627x9 58 4 time time NN cord-325325-xw7627x9 58 5 , , , cord-325325-xw7627x9 58 6 more more JJR cord-325325-xw7627x9 58 7 evidence evidence NN cord-325325-xw7627x9 58 8 supports support VBZ cord-325325-xw7627x9 58 9 the the DT cord-325325-xw7627x9 58 10 role role NN cord-325325-xw7627x9 58 11 of of IN cord-325325-xw7627x9 58 12 the the DT cord-325325-xw7627x9 58 13 international international JJ cord-325325-xw7627x9 58 14 illegal illegal JJ cord-325325-xw7627x9 58 15 poultry poultry NN cord-325325-xw7627x9 58 16 trade trade NN cord-325325-xw7627x9 58 17 . . . cord-325325-xw7627x9 59 1 It -PRON- PRP cord-325325-xw7627x9 59 2 is be VBZ cord-325325-xw7627x9 59 3 possible possible JJ cord-325325-xw7627x9 59 4 that that IN cord-325325-xw7627x9 59 5 this this DT cord-325325-xw7627x9 59 6 trade trade NN cord-325325-xw7627x9 59 7 contributed contribute VBD cord-325325-xw7627x9 59 8 to to IN cord-325325-xw7627x9 59 9 the the DT cord-325325-xw7627x9 59 10 2006 2006 CD cord-325325-xw7627x9 59 11 H5N1 H5N1 NNP cord-325325-xw7627x9 59 12 outbreak outbreak NN cord-325325-xw7627x9 59 13 in in IN cord-325325-xw7627x9 59 14 a a DT cord-325325-xw7627x9 59 15 large large JJ cord-325325-xw7627x9 59 16 commercial commercial JJ cord-325325-xw7627x9 59 17 farm farm NN cord-325325-xw7627x9 59 18 in in IN cord-325325-xw7627x9 59 19 Kaduna Kaduna NNP cord-325325-xw7627x9 59 20 State State NNP cord-325325-xw7627x9 59 21 in in IN cord-325325-xw7627x9 59 22 the the DT cord-325325-xw7627x9 59 23 northern northern JJ cord-325325-xw7627x9 59 24 part part NN cord-325325-xw7627x9 59 25 of of IN cord-325325-xw7627x9 59 26 Nigeria Nigeria NNP cord-325325-xw7627x9 59 27 . . . cord-325325-xw7627x9 60 1 On on IN cord-325325-xw7627x9 60 2 the the DT cord-325325-xw7627x9 60 3 other other JJ cord-325325-xw7627x9 60 4 hand hand NN cord-325325-xw7627x9 60 5 , , , cord-325325-xw7627x9 60 6 the the DT cord-325325-xw7627x9 60 7 country country NN cord-325325-xw7627x9 60 8 is be VBZ cord-325325-xw7627x9 60 9 known know VBN cord-325325-xw7627x9 60 10 to to TO cord-325325-xw7627x9 60 11 lie lie VB cord-325325-xw7627x9 60 12 along along IN cord-325325-xw7627x9 60 13 a a DT cord-325325-xw7627x9 60 14 flight flight NN cord-325325-xw7627x9 60 15 route route NN cord-325325-xw7627x9 60 16 for for IN cord-325325-xw7627x9 60 17 birds bird NNS cord-325325-xw7627x9 60 18 migrating migrate VBG cord-325325-xw7627x9 60 19 from from IN cord-325325-xw7627x9 60 20 central central JJ cord-325325-xw7627x9 60 21 Asia Asia NNP cord-325325-xw7627x9 60 22 . . . cord-325325-xw7627x9 61 1 The the DT cord-325325-xw7627x9 61 2 birds bird NNS cord-325325-xw7627x9 61 3 shed shed VBD cord-325325-xw7627x9 61 4 the the DT cord-325325-xw7627x9 61 5 virus virus NN cord-325325-xw7627x9 61 6 in in IN cord-325325-xw7627x9 61 7 their -PRON- PRP$ cord-325325-xw7627x9 61 8 saliva saliva NN cord-325325-xw7627x9 61 9 , , , cord-325325-xw7627x9 61 10 nasal nasal JJ cord-325325-xw7627x9 61 11 secretions secretion NNS cord-325325-xw7627x9 61 12 , , , cord-325325-xw7627x9 61 13 and and CC cord-325325-xw7627x9 61 14 feces fece NNS cord-325325-xw7627x9 61 15 . . . cord-325325-xw7627x9 62 1 Infection infection NN cord-325325-xw7627x9 62 2 can can MD cord-325325-xw7627x9 62 3 spread spread VB cord-325325-xw7627x9 62 4 among among IN cord-325325-xw7627x9 62 5 birds bird NNS cord-325325-xw7627x9 62 6 by by IN cord-325325-xw7627x9 62 7 contact contact NN cord-325325-xw7627x9 62 8 with with IN cord-325325-xw7627x9 62 9 infected infected JJ cord-325325-xw7627x9 62 10 birds bird NNS cord-325325-xw7627x9 62 11 or or CC cord-325325-xw7627x9 62 12 with with IN cord-325325-xw7627x9 62 13 their -PRON- PRP$ cord-325325-xw7627x9 62 14 excretions excretion NNS cord-325325-xw7627x9 62 15 . . . cord-325325-xw7627x9 63 1 People People NNS cord-325325-xw7627x9 63 2 can can MD cord-325325-xw7627x9 63 3 get get VB cord-325325-xw7627x9 63 4 infected infect VBN cord-325325-xw7627x9 63 5 by by IN cord-325325-xw7627x9 63 6 direct direct JJ cord-325325-xw7627x9 63 7 or or CC cord-325325-xw7627x9 63 8 close close JJ cord-325325-xw7627x9 63 9 contact contact NN cord-325325-xw7627x9 63 10 with with IN cord-325325-xw7627x9 63 11 infected infected JJ cord-325325-xw7627x9 63 12 poultry poultry NN cord-325325-xw7627x9 63 13 or or CC cord-325325-xw7627x9 63 14 surfaces surface NNS cord-325325-xw7627x9 63 15 contaminated contaminate VBN cord-325325-xw7627x9 63 16 with with IN cord-325325-xw7627x9 63 17 secretions secretion NNS cord-325325-xw7627x9 63 18 and and CC cord-325325-xw7627x9 63 19 excretions excretion NNS cord-325325-xw7627x9 63 20 from from IN cord-325325-xw7627x9 63 21 the the DT cord-325325-xw7627x9 63 22 infected infected JJ cord-325325-xw7627x9 63 23 birds bird NNS cord-325325-xw7627x9 63 24 . . . cord-325325-xw7627x9 64 1 Human human JJ cord-325325-xw7627x9 64 2 exposure exposure NN cord-325325-xw7627x9 64 3 occurs occur VBZ cord-325325-xw7627x9 64 4 most most RBS cord-325325-xw7627x9 64 5 often often RB cord-325325-xw7627x9 64 6 during during IN cord-325325-xw7627x9 64 7 slaughtering slaughter VBG cord-325325-xw7627x9 64 8 , , , cord-325325-xw7627x9 64 9 de de NN cord-325325-xw7627x9 64 10 - - NN cord-325325-xw7627x9 64 11 feathering feathering NN cord-325325-xw7627x9 64 12 , , , cord-325325-xw7627x9 64 13 butchering butchering NN cord-325325-xw7627x9 64 14 , , , cord-325325-xw7627x9 64 15 or or CC cord-325325-xw7627x9 64 16 preparation preparation NN cord-325325-xw7627x9 64 17 for for IN cord-325325-xw7627x9 64 18 cooking cooking NN cord-325325-xw7627x9 64 19 . . . cord-325325-xw7627x9 65 1 Raw raw JJ cord-325325-xw7627x9 65 2 poultry poultry NN cord-325325-xw7627x9 65 3 or or CC cord-325325-xw7627x9 65 4 eggs egg NNS cord-325325-xw7627x9 65 5 can can MD cord-325325-xw7627x9 65 6 also also RB cord-325325-xw7627x9 65 7 transmit transmit VB cord-325325-xw7627x9 65 8 the the DT cord-325325-xw7627x9 65 9 disease disease NN cord-325325-xw7627x9 65 10 . . . cord-325325-xw7627x9 66 1 There there EX cord-325325-xw7627x9 66 2 are be VBP cord-325325-xw7627x9 66 3 no no RB cord-325325-xw7627x9 66 4 reported report VBN cord-325325-xw7627x9 66 5 cases case NNS cord-325325-xw7627x9 66 6 through through IN cord-325325-xw7627x9 66 7 properly properly RB cord-325325-xw7627x9 66 8 cooked cook VBN cord-325325-xw7627x9 66 9 poultry poultry NN cord-325325-xw7627x9 66 10 . . . cord-325325-xw7627x9 67 1 15 15 CD cord-325325-xw7627x9 67 2 , , , cord-325325-xw7627x9 67 3 20 20 CD cord-325325-xw7627x9 67 4 Human human NN cord-325325-xw7627x9 67 5 - - HYPH cord-325325-xw7627x9 67 6 to to IN cord-325325-xw7627x9 67 7 - - HYPH cord-325325-xw7627x9 67 8 human human JJ cord-325325-xw7627x9 67 9 transmission transmission NN cord-325325-xw7627x9 67 10 was be VBD cord-325325-xw7627x9 67 11 suggested suggest VBN cord-325325-xw7627x9 67 12 in in IN cord-325325-xw7627x9 67 13 a a DT cord-325325-xw7627x9 67 14 family family NN cord-325325-xw7627x9 67 15 in in IN cord-325325-xw7627x9 67 16 Thailand Thailand NNP cord-325325-xw7627x9 67 17 , , , cord-325325-xw7627x9 67 18 when when WRB cord-325325-xw7627x9 67 19 an an DT cord-325325-xw7627x9 67 20 11-year 11-year JJ cord-325325-xw7627x9 67 21 - - HYPH cord-325325-xw7627x9 67 22 old old JJ cord-325325-xw7627x9 67 23 girl girl NN cord-325325-xw7627x9 67 24 who who WP cord-325325-xw7627x9 67 25 had have VBD cord-325325-xw7627x9 67 26 been be VBN cord-325325-xw7627x9 67 27 in in IN cord-325325-xw7627x9 67 28 contact contact NN cord-325325-xw7627x9 67 29 with with IN cord-325325-xw7627x9 67 30 an an DT cord-325325-xw7627x9 67 31 infected infected JJ cord-325325-xw7627x9 67 32 bird bird NN cord-325325-xw7627x9 67 33 , , , cord-325325-xw7627x9 67 34 and and CC cord-325325-xw7627x9 67 35 her -PRON- PRP$ cord-325325-xw7627x9 67 36 mother mother NN cord-325325-xw7627x9 67 37 who who WP cord-325325-xw7627x9 67 38 had have VBD cord-325325-xw7627x9 67 39 provided provide VBN cord-325325-xw7627x9 67 40 her -PRON- PRP cord-325325-xw7627x9 67 41 with with IN cord-325325-xw7627x9 67 42 nursing nursing NN cord-325325-xw7627x9 67 43 care care NN cord-325325-xw7627x9 67 44 , , , cord-325325-xw7627x9 67 45 both both DT cord-325325-xw7627x9 67 46 died die VBD cord-325325-xw7627x9 67 47 of of IN cord-325325-xw7627x9 67 48 the the DT cord-325325-xw7627x9 67 49 avian avian JJ cord-325325-xw7627x9 67 50 influenza influenza NN cord-325325-xw7627x9 67 51 . . . cord-325325-xw7627x9 68 1 The the DT cord-325325-xw7627x9 68 2 girl girl NN cord-325325-xw7627x9 68 3 's 's POS cord-325325-xw7627x9 68 4 aunt aunt NN cord-325325-xw7627x9 68 5 , , , cord-325325-xw7627x9 68 6 who who WP cord-325325-xw7627x9 68 7 had have VBD cord-325325-xw7627x9 68 8 also also RB cord-325325-xw7627x9 68 9 had have VBN cord-325325-xw7627x9 68 10 close close JJ cord-325325-xw7627x9 68 11 contact contact NN cord-325325-xw7627x9 68 12 with with IN cord-325325-xw7627x9 68 13 the the DT cord-325325-xw7627x9 68 14 girl girl NN cord-325325-xw7627x9 68 15 , , , cord-325325-xw7627x9 68 16 survived survive VBD cord-325325-xw7627x9 68 17 the the DT cord-325325-xw7627x9 68 18 infection infection NN cord-325325-xw7627x9 68 19 after after IN cord-325325-xw7627x9 68 20 treatment treatment NN cord-325325-xw7627x9 68 21 with with IN cord-325325-xw7627x9 68 22 oseltamivir oseltamivir NNP cord-325325-xw7627x9 68 23 . . . cord-325325-xw7627x9 69 1 H5N1 H5N1 NNP cord-325325-xw7627x9 69 2 was be VBD cord-325325-xw7627x9 69 3 confirmed confirm VBN cord-325325-xw7627x9 69 4 in in IN cord-325325-xw7627x9 69 5 the the DT cord-325325-xw7627x9 69 6 mother mother NN cord-325325-xw7627x9 69 7 and and CC cord-325325-xw7627x9 69 8 the the DT cord-325325-xw7627x9 69 9 aunt aunt NN cord-325325-xw7627x9 69 10 . . . cord-325325-xw7627x9 70 1 21 21 CD cord-325325-xw7627x9 70 2 , , , cord-325325-xw7627x9 70 3 22 22 CD cord-325325-xw7627x9 71 1 Recently recently RB cord-325325-xw7627x9 71 2 there there EX cord-325325-xw7627x9 71 3 have have VBP cord-325325-xw7627x9 71 4 been be VBN cord-325325-xw7627x9 71 5 fears fear NNS cord-325325-xw7627x9 71 6 of of IN cord-325325-xw7627x9 71 7 other other JJ cord-325325-xw7627x9 71 8 human human NN cord-325325-xw7627x9 71 9 - - HYPH cord-325325-xw7627x9 71 10 to to IN cord-325325-xw7627x9 71 11 - - HYPH cord-325325-xw7627x9 71 12 human human JJ cord-325325-xw7627x9 71 13 transmission transmission NN cord-325325-xw7627x9 71 14 cases case NNS cord-325325-xw7627x9 71 15 after after IN cord-325325-xw7627x9 71 16 seven seven CD cord-325325-xw7627x9 71 17 family family NN cord-325325-xw7627x9 71 18 members member NNS cord-325325-xw7627x9 71 19 died die VBD cord-325325-xw7627x9 71 20 of of IN cord-325325-xw7627x9 71 21 the the DT cord-325325-xw7627x9 71 22 avian avian JJ cord-325325-xw7627x9 71 23 influenza influenza NN cord-325325-xw7627x9 71 24 in in IN cord-325325-xw7627x9 71 25 Indonesia Indonesia NNP cord-325325-xw7627x9 71 26 . . . cord-325325-xw7627x9 72 1 WHO who WP cord-325325-xw7627x9 72 2 confirmed confirm VBD cord-325325-xw7627x9 72 3 that that IN cord-325325-xw7627x9 72 4 partial partial JJ cord-325325-xw7627x9 72 5 human human NN cord-325325-xw7627x9 72 6 - - HYPH cord-325325-xw7627x9 72 7 to to IN cord-325325-xw7627x9 72 8 - - HYPH cord-325325-xw7627x9 72 9 human human JJ cord-325325-xw7627x9 72 10 transmission transmission NN cord-325325-xw7627x9 72 11 occurred occur VBD cord-325325-xw7627x9 72 12 . . . cord-325325-xw7627x9 73 1 20 20 CD cord-325325-xw7627x9 73 2 Other other JJ cord-325325-xw7627x9 73 3 potential potential JJ cord-325325-xw7627x9 73 4 modes mode NNS cord-325325-xw7627x9 73 5 of of IN cord-325325-xw7627x9 73 6 transmission transmission NN cord-325325-xw7627x9 73 7 of of IN cord-325325-xw7627x9 73 8 H5N1 H5N1 NNP cord-325325-xw7627x9 73 9 virus virus NN cord-325325-xw7627x9 73 10 include include VBP cord-325325-xw7627x9 73 11 contamination contamination NN cord-325325-xw7627x9 73 12 of of IN cord-325325-xw7627x9 73 13 hands hand NNS cord-325325-xw7627x9 73 14 from from IN cord-325325-xw7627x9 73 15 infected infected JJ cord-325325-xw7627x9 73 16 fomites fomite NNS cord-325325-xw7627x9 73 17 and and CC cord-325325-xw7627x9 73 18 exposure exposure NN cord-325325-xw7627x9 73 19 to to IN cord-325325-xw7627x9 73 20 untreated untreated JJ cord-325325-xw7627x9 73 21 poultry poultry NN cord-325325-xw7627x9 73 22 feces fece NNS cord-325325-xw7627x9 73 23 used use VBN cord-325325-xw7627x9 73 24 as as IN cord-325325-xw7627x9 73 25 fertilizers fertilizer NNS cord-325325-xw7627x9 73 26 . . . cord-325325-xw7627x9 74 1 Further further RB cord-325325-xw7627x9 74 2 possible possible JJ cord-325325-xw7627x9 74 3 but but CC cord-325325-xw7627x9 74 4 not not RB cord-325325-xw7627x9 74 5 proven prove VBN cord-325325-xw7627x9 74 6 modes mode NNS cord-325325-xw7627x9 74 7 of of IN cord-325325-xw7627x9 74 8 transmission transmission NN cord-325325-xw7627x9 74 9 are be VBP cord-325325-xw7627x9 74 10 oral oral JJ cord-325325-xw7627x9 74 11 ingestion ingestion NN cord-325325-xw7627x9 74 12 of of IN cord-325325-xw7627x9 74 13 contaminated contaminated JJ cord-325325-xw7627x9 74 14 water water NN cord-325325-xw7627x9 74 15 during during IN cord-325325-xw7627x9 74 16 swimming swimming NN cord-325325-xw7627x9 74 17 and and CC cord-325325-xw7627x9 74 18 direct direct JJ cord-325325-xw7627x9 74 19 intranasal intranasal NN cord-325325-xw7627x9 74 20 or or CC cord-325325-xw7627x9 74 21 conjunctival conjunctival NN cord-325325-xw7627x9 74 22 inoculation inoculation NN cord-325325-xw7627x9 74 23 during during IN cord-325325-xw7627x9 74 24 exposure exposure NN cord-325325-xw7627x9 74 25 to to IN cord-325325-xw7627x9 74 26 water water NN cord-325325-xw7627x9 74 27 . . . cord-325325-xw7627x9 75 1 23 23 CD cord-325325-xw7627x9 75 2 _SP cord-325325-xw7627x9 76 1 The the DT cord-325325-xw7627x9 76 2 virulence virulence NN cord-325325-xw7627x9 76 3 of of IN cord-325325-xw7627x9 76 4 the the DT cord-325325-xw7627x9 76 5 avian avian JJ cord-325325-xw7627x9 76 6 influenza influenza NN cord-325325-xw7627x9 76 7 viruses virus NNS cord-325325-xw7627x9 76 8 in in IN cord-325325-xw7627x9 76 9 mammals mammal NNS cord-325325-xw7627x9 76 10 is be VBZ cord-325325-xw7627x9 76 11 not not RB cord-325325-xw7627x9 76 12 well well RB cord-325325-xw7627x9 76 13 understood understand VBN cord-325325-xw7627x9 76 14 . . . cord-325325-xw7627x9 77 1 As as IN cord-325325-xw7627x9 77 2 opposed oppose VBN cord-325325-xw7627x9 77 3 to to IN cord-325325-xw7627x9 77 4 the the DT cord-325325-xw7627x9 77 5 earlier early JJR cord-325325-xw7627x9 77 6 H5 H5 NNP cord-325325-xw7627x9 77 7 viruses virus NNS cord-325325-xw7627x9 77 8 , , , cord-325325-xw7627x9 77 9 the the DT cord-325325-xw7627x9 77 10 more more RBR cord-325325-xw7627x9 77 11 recently recently RB cord-325325-xw7627x9 77 12 circulating circulate VBG cord-325325-xw7627x9 77 13 H5 h5 NN cord-325325-xw7627x9 77 14 viruses virus NNS cord-325325-xw7627x9 77 15 appear appear VBP cord-325325-xw7627x9 77 16 to to TO cord-325325-xw7627x9 77 17 be be VB cord-325325-xw7627x9 77 18 more more RBR cord-325325-xw7627x9 77 19 pathogenic pathogenic JJ cord-325325-xw7627x9 77 20 in in IN cord-325325-xw7627x9 77 21 mammals mammal NNS cord-325325-xw7627x9 77 22 and and CC cord-325325-xw7627x9 77 23 birds bird NNS cord-325325-xw7627x9 77 24 . . . cord-325325-xw7627x9 78 1 This this DT cord-325325-xw7627x9 78 2 is be VBZ cord-325325-xw7627x9 78 3 a a DT cord-325325-xw7627x9 78 4 feature feature NN cord-325325-xw7627x9 78 5 that that WDT cord-325325-xw7627x9 78 6 may may MD cord-325325-xw7627x9 78 7 precede precede VB cord-325325-xw7627x9 78 8 the the DT cord-325325-xw7627x9 78 9 emergence emergence NN cord-325325-xw7627x9 78 10 of of IN cord-325325-xw7627x9 78 11 reassorted reassorted JJ cord-325325-xw7627x9 78 12 H5 H5 NNP cord-325325-xw7627x9 78 13 strains strain NNS cord-325325-xw7627x9 78 14 with with IN cord-325325-xw7627x9 78 15 pandemic pandemic NN cord-325325-xw7627x9 78 16 potential potential NN cord-325325-xw7627x9 78 17 . . . cord-325325-xw7627x9 79 1 17 17 CD cord-325325-xw7627x9 79 2 , , , cord-325325-xw7627x9 79 3 24 24 CD cord-325325-xw7627x9 80 1 Although although IN cord-325325-xw7627x9 80 2 virulence virulence NN cord-325325-xw7627x9 80 3 determinants determinant NNS cord-325325-xw7627x9 80 4 are be VBP cord-325325-xw7627x9 80 5 polygenic polygenic JJ cord-325325-xw7627x9 80 6 traits trait NNS cord-325325-xw7627x9 80 7 , , , cord-325325-xw7627x9 80 8 the the DT cord-325325-xw7627x9 80 9 possible possible JJ cord-325325-xw7627x9 80 10 major major JJ cord-325325-xw7627x9 80 11 contributing contributing NN cord-325325-xw7627x9 80 12 factor factor NN cord-325325-xw7627x9 80 13 is be VBZ cord-325325-xw7627x9 80 14 the the DT cord-325325-xw7627x9 80 15 hemagglutinin hemagglutinin NN cord-325325-xw7627x9 80 16 molecule molecule NN cord-325325-xw7627x9 80 17 . . . cord-325325-xw7627x9 81 1 The the DT cord-325325-xw7627x9 81 2 acquisition acquisition NN cord-325325-xw7627x9 81 3 of of IN cord-325325-xw7627x9 81 4 a a DT cord-325325-xw7627x9 81 5 multibasic multibasic NN cord-325325-xw7627x9 81 6 amino amino NN cord-325325-xw7627x9 81 7 acid acid NN cord-325325-xw7627x9 81 8 sequence sequence NN cord-325325-xw7627x9 81 9 at at IN cord-325325-xw7627x9 81 10 the the DT cord-325325-xw7627x9 81 11 cleavage cleavage NN cord-325325-xw7627x9 81 12 site site NN cord-325325-xw7627x9 81 13 of of IN cord-325325-xw7627x9 81 14 a a DT cord-325325-xw7627x9 81 15 hemagglutinin hemagglutinin NN cord-325325-xw7627x9 81 16 belonging belong VBG cord-325325-xw7627x9 81 17 to to IN cord-325325-xw7627x9 81 18 the the DT cord-325325-xw7627x9 81 19 H5 H5 NNP cord-325325-xw7627x9 81 20 or or CC cord-325325-xw7627x9 81 21 H7 H7 NNP cord-325325-xw7627x9 81 22 subtypes subtype NNS cord-325325-xw7627x9 81 23 enables enable VBZ cord-325325-xw7627x9 81 24 its -PRON- PRP$ cord-325325-xw7627x9 81 25 widespread widespread JJ cord-325325-xw7627x9 81 26 cleavage cleavage NN cord-325325-xw7627x9 81 27 by by IN cord-325325-xw7627x9 81 28 ubiquitous ubiquitous JJ cord-325325-xw7627x9 81 29 tissue tissue NN cord-325325-xw7627x9 81 30 proteases protease NNS cord-325325-xw7627x9 81 31 , , , cord-325325-xw7627x9 81 32 resulting result VBG cord-325325-xw7627x9 81 33 in in IN cord-325325-xw7627x9 81 34 multi multi JJ cord-325325-xw7627x9 81 35 - - JJ cord-325325-xw7627x9 81 36 organ organ JJ cord-325325-xw7627x9 81 37 infection infection NN cord-325325-xw7627x9 81 38 and and CC cord-325325-xw7627x9 81 39 high high JJ cord-325325-xw7627x9 81 40 pathogenicity pathogenicity NN cord-325325-xw7627x9 81 41 . . . cord-325325-xw7627x9 82 1 25 25 CD cord-325325-xw7627x9 82 2 , , , cord-325325-xw7627x9 82 3 26 26 CD cord-325325-xw7627x9 82 4 H5N1 H5N1 NNP cord-325325-xw7627x9 82 5 viruses virus NNS cord-325325-xw7627x9 82 6 are be VBP cord-325325-xw7627x9 82 7 relatively relatively RB cord-325325-xw7627x9 82 8 resistant resistant JJ cord-325325-xw7627x9 82 9 to to TO cord-325325-xw7627x9 82 10 host host VB cord-325325-xw7627x9 82 11 antiviral antiviral JJ cord-325325-xw7627x9 82 12 cytokines cytokine NNS cord-325325-xw7627x9 82 13 , , , cord-325325-xw7627x9 82 14 which which WDT cord-325325-xw7627x9 82 15 leads lead VBZ cord-325325-xw7627x9 82 16 to to IN cord-325325-xw7627x9 82 17 the the DT cord-325325-xw7627x9 82 18 production production NN cord-325325-xw7627x9 82 19 of of IN cord-325325-xw7627x9 82 20 high high JJ cord-325325-xw7627x9 82 21 levels level NNS cord-325325-xw7627x9 82 22 of of IN cord-325325-xw7627x9 82 23 cytokines cytokine NNS cord-325325-xw7627x9 82 24 and and CC cord-325325-xw7627x9 82 25 an an DT cord-325325-xw7627x9 82 26 excessive excessive JJ cord-325325-xw7627x9 82 27 pro pro JJ cord-325325-xw7627x9 82 28 - - JJ cord-325325-xw7627x9 82 29 inflammatory inflammatory JJ cord-325325-xw7627x9 82 30 response response NN cord-325325-xw7627x9 82 31 causing cause VBG cord-325325-xw7627x9 82 32 tissue tissue NN cord-325325-xw7627x9 82 33 injury injury NN cord-325325-xw7627x9 82 34 . . . cord-325325-xw7627x9 83 1 27 27 CD cord-325325-xw7627x9 83 2 , , , cord-325325-xw7627x9 83 3 28 28 CD cord-325325-xw7627x9 84 1 This this DT cord-325325-xw7627x9 84 2 suggests suggest VBZ cord-325325-xw7627x9 84 3 that that IN cord-325325-xw7627x9 84 4 the the DT cord-325325-xw7627x9 84 5 severity severity NN cord-325325-xw7627x9 84 6 of of IN cord-325325-xw7627x9 84 7 human human JJ cord-325325-xw7627x9 84 8 H5N1 H5N1 NNP cord-325325-xw7627x9 84 9 infection infection NN cord-325325-xw7627x9 84 10 may may MD cord-325325-xw7627x9 84 11 be be VB cord-325325-xw7627x9 84 12 related relate VBN cord-325325-xw7627x9 84 13 to to IN cord-325325-xw7627x9 84 14 the the DT cord-325325-xw7627x9 84 15 excessive excessive JJ cord-325325-xw7627x9 84 16 pro pro JJ cord-325325-xw7627x9 84 17 - - JJ cord-325325-xw7627x9 84 18 inflammatory inflammatory JJ cord-325325-xw7627x9 84 19 responses response NNS cord-325325-xw7627x9 84 20 that that WDT cord-325325-xw7627x9 84 21 exacerbate exacerbate VBP cord-325325-xw7627x9 84 22 tissue tissue NN cord-325325-xw7627x9 84 23 injury injury NN cord-325325-xw7627x9 84 24 . . . cord-325325-xw7627x9 85 1 23 23 CD cord-325325-xw7627x9 85 2 , , , cord-325325-xw7627x9 85 3 29 29 CD cord-325325-xw7627x9 85 4 Autopsies autopsy NNS cord-325325-xw7627x9 85 5 of of IN cord-325325-xw7627x9 85 6 current current JJ cord-325325-xw7627x9 85 7 human human JJ cord-325325-xw7627x9 85 8 cases case NNS cord-325325-xw7627x9 85 9 of of IN cord-325325-xw7627x9 85 10 H5N1 H5N1 NNP cord-325325-xw7627x9 85 11 influenza influenza NN cord-325325-xw7627x9 85 12 have have VBP cord-325325-xw7627x9 85 13 revealed reveal VBN cord-325325-xw7627x9 85 14 necrotizing necrotize VBG cord-325325-xw7627x9 85 15 hemorrhagic hemorrhagic JJ cord-325325-xw7627x9 85 16 pneumonia pneumonia NN cord-325325-xw7627x9 85 17 , , , cord-325325-xw7627x9 85 18 similar similar JJ cord-325325-xw7627x9 85 19 to to IN cord-325325-xw7627x9 85 20 that that DT cord-325325-xw7627x9 85 21 found find VBN cord-325325-xw7627x9 85 22 in in IN cord-325325-xw7627x9 85 23 the the DT cord-325325-xw7627x9 85 24 1918 1918 CD cord-325325-xw7627x9 85 25 influenza influenza NN cord-325325-xw7627x9 85 26 cases case NNS cord-325325-xw7627x9 85 27 . . . cord-325325-xw7627x9 86 1 Like like IN cord-325325-xw7627x9 86 2 the the DT cord-325325-xw7627x9 86 3 1918 1918 CD cord-325325-xw7627x9 86 4 virus virus NN cord-325325-xw7627x9 86 5 , , , cord-325325-xw7627x9 86 6 H5N1 H5N1 NNP cord-325325-xw7627x9 86 7 is be VBZ cord-325325-xw7627x9 86 8 associated associate VBN cord-325325-xw7627x9 86 9 with with IN cord-325325-xw7627x9 86 10 unusually unusually RB cord-325325-xw7627x9 86 11 high high JJ cord-325325-xw7627x9 86 12 death death NN cord-325325-xw7627x9 86 13 rates rate NNS cord-325325-xw7627x9 86 14 in in IN cord-325325-xw7627x9 86 15 humans human NNS cord-325325-xw7627x9 86 16 ; ; : cord-325325-xw7627x9 86 17 in in IN cord-325325-xw7627x9 86 18 fact fact NN cord-325325-xw7627x9 86 19 the the DT cord-325325-xw7627x9 86 20 case case NN cord-325325-xw7627x9 86 21 death death NN cord-325325-xw7627x9 86 22 rate rate NN cord-325325-xw7627x9 86 23 is be VBZ cord-325325-xw7627x9 86 24 20 20 CD cord-325325-xw7627x9 86 25 times time NNS cord-325325-xw7627x9 86 26 higher high JJR cord-325325-xw7627x9 86 27 than than IN cord-325325-xw7627x9 86 28 that that DT cord-325325-xw7627x9 86 29 of of IN cord-325325-xw7627x9 86 30 the the DT cord-325325-xw7627x9 86 31 1918 1918 CD cord-325325-xw7627x9 86 32 virus virus NN cord-325325-xw7627x9 86 33 ( ( -LRB- cord-325325-xw7627x9 86 34 50 50 CD cord-325325-xw7627x9 86 35 % % NN cord-325325-xw7627x9 86 36 vs. vs. IN cord-325325-xw7627x9 86 37 2.5 2.5 CD cord-325325-xw7627x9 86 38 % % NN cord-325325-xw7627x9 86 39 ) ) -RRB- cord-325325-xw7627x9 86 40 . . . cord-325325-xw7627x9 87 1 30 30 CD cord-325325-xw7627x9 88 1 Continuous continuous JJ cord-325325-xw7627x9 88 2 evolution evolution NN cord-325325-xw7627x9 88 3 of of IN cord-325325-xw7627x9 88 4 the the DT cord-325325-xw7627x9 88 5 H5N1 H5N1 NNP cord-325325-xw7627x9 88 6 virus virus NN cord-325325-xw7627x9 88 7 has have VBZ cord-325325-xw7627x9 88 8 been be VBN cord-325325-xw7627x9 88 9 suggested suggest VBN cord-325325-xw7627x9 88 10 by by IN cord-325325-xw7627x9 88 11 changes change NNS cord-325325-xw7627x9 88 12 in in IN cord-325325-xw7627x9 88 13 the the DT cord-325325-xw7627x9 88 14 internal internal JJ cord-325325-xw7627x9 88 15 gene gene NN cord-325325-xw7627x9 88 16 constellation constellation NN cord-325325-xw7627x9 88 17 , , , cord-325325-xw7627x9 88 18 expanded expand VBD cord-325325-xw7627x9 88 19 host host NN cord-325325-xw7627x9 88 20 range range NN cord-325325-xw7627x9 88 21 , , , cord-325325-xw7627x9 88 22 increased increase VBN cord-325325-xw7627x9 88 23 pathogenicity pathogenicity NN cord-325325-xw7627x9 88 24 , , , cord-325325-xw7627x9 88 25 and and CC cord-325325-xw7627x9 88 26 greater great JJR cord-325325-xw7627x9 88 27 environmental environmental JJ cord-325325-xw7627x9 88 28 stability stability NN cord-325325-xw7627x9 88 29 . . . cord-325325-xw7627x9 89 1 31 31 CD cord-325325-xw7627x9 89 2 , , , cord-325325-xw7627x9 89 3 32 32 CD cord-325325-xw7627x9 89 4 Symptoms symptom NNS cord-325325-xw7627x9 89 5 and and CC cord-325325-xw7627x9 89 6 signs sign NNS cord-325325-xw7627x9 90 1 According accord VBG cord-325325-xw7627x9 90 2 to to IN cord-325325-xw7627x9 90 3 one one CD cord-325325-xw7627x9 90 4 study study NN cord-325325-xw7627x9 90 5 , , , cord-325325-xw7627x9 90 6 symptoms symptom NNS cord-325325-xw7627x9 90 7 of of IN cord-325325-xw7627x9 90 8 H5N1 H5N1 NNP cord-325325-xw7627x9 90 9 infection infection NN cord-325325-xw7627x9 90 10 include include VBP cord-325325-xw7627x9 90 11 typical typical JJ cord-325325-xw7627x9 90 12 influenza influenza NN cord-325325-xw7627x9 90 13 - - HYPH cord-325325-xw7627x9 90 14 like like JJ cord-325325-xw7627x9 90 15 symptoms symptom NNS cord-325325-xw7627x9 90 16 : : : cord-325325-xw7627x9 90 17 fever fever NN cord-325325-xw7627x9 90 18 ( ( -LRB- cord-325325-xw7627x9 90 19 100 100 CD cord-325325-xw7627x9 90 20 % % NN cord-325325-xw7627x9 90 21 ) ) -RRB- cord-325325-xw7627x9 90 22 , , , cord-325325-xw7627x9 90 23 cough cough NN cord-325325-xw7627x9 90 24 and and CC cord-325325-xw7627x9 90 25 sore sore JJ cord-325325-xw7627x9 90 26 throat throat NN cord-325325-xw7627x9 90 27 ( ( -LRB- cord-325325-xw7627x9 90 28 67 67 CD cord-325325-xw7627x9 90 29 % % NN cord-325325-xw7627x9 90 30 ) ) -RRB- cord-325325-xw7627x9 90 31 , , , cord-325325-xw7627x9 90 32 myalgias myalgias NNP cord-325325-xw7627x9 90 33 ( ( -LRB- cord-325325-xw7627x9 90 34 30 30 CD cord-325325-xw7627x9 90 35 % % NN cord-325325-xw7627x9 90 36 ) ) -RRB- cord-325325-xw7627x9 90 37 , , , cord-325325-xw7627x9 90 38 pneumonia pneumonia NN cord-325325-xw7627x9 90 39 ( ( -LRB- cord-325325-xw7627x9 90 40 58 58 CD cord-325325-xw7627x9 90 41 % % NN cord-325325-xw7627x9 90 42 ) ) -RRB- cord-325325-xw7627x9 90 43 , , , cord-325325-xw7627x9 90 44 diarrhea diarrhea NN cord-325325-xw7627x9 90 45 and and CC cord-325325-xw7627x9 90 46 vomiting vomit VBG cord-325325-xw7627x9 90 47 ( ( -LRB- cord-325325-xw7627x9 90 48 50 50 CD cord-325325-xw7627x9 90 49 % % NN cord-325325-xw7627x9 90 50 ) ) -RRB- cord-325325-xw7627x9 90 51 , , , cord-325325-xw7627x9 90 52 and and CC cord-325325-xw7627x9 90 53 congestion congestion NN cord-325325-xw7627x9 90 54 of of IN cord-325325-xw7627x9 90 55 the the DT cord-325325-xw7627x9 90 56 conjunctiva conjunctiva NN cord-325325-xw7627x9 90 57 ( ( -LRB- cord-325325-xw7627x9 90 58 0 0 CD cord-325325-xw7627x9 90 59 % % NN cord-325325-xw7627x9 90 60 ) ) -RRB- cord-325325-xw7627x9 90 61 . . . cord-325325-xw7627x9 91 1 Laboratory laboratory NN cord-325325-xw7627x9 91 2 findings finding NNS cord-325325-xw7627x9 91 3 include include VBP cord-325325-xw7627x9 91 4 elevated elevated JJ cord-325325-xw7627x9 91 5 serum serum NN cord-325325-xw7627x9 91 6 aminotransferases aminotransferase NNS cord-325325-xw7627x9 91 7 and and CC cord-325325-xw7627x9 91 8 pancytopenias pancytopenias NNP cord-325325-xw7627x9 91 9 . . . cord-325325-xw7627x9 92 1 23 23 CD cord-325325-xw7627x9 92 2 , , , cord-325325-xw7627x9 92 3 33 33 CD cord-325325-xw7627x9 92 4 Complications complication NNS cord-325325-xw7627x9 92 5 include include VBP cord-325325-xw7627x9 92 6 acute acute JJ cord-325325-xw7627x9 92 7 respiratory respiratory JJ cord-325325-xw7627x9 92 8 distress distress NN cord-325325-xw7627x9 92 9 syndrome syndrome NN cord-325325-xw7627x9 92 10 ( ( -LRB- cord-325325-xw7627x9 92 11 ARDS ARDS NNP cord-325325-xw7627x9 92 12 ) ) -RRB- cord-325325-xw7627x9 92 13 , , , cord-325325-xw7627x9 92 14 pulmonary pulmonary JJ cord-325325-xw7627x9 92 15 hemorrhage hemorrhage NN cord-325325-xw7627x9 92 16 , , , cord-325325-xw7627x9 92 17 myocarditis myocarditis NN cord-325325-xw7627x9 92 18 , , , cord-325325-xw7627x9 92 19 pericarditis pericarditis NN cord-325325-xw7627x9 92 20 , , , cord-325325-xw7627x9 92 21 encephalitis encephalitis RB cord-325325-xw7627x9 92 22 , , , cord-325325-xw7627x9 92 23 multi multi JJ cord-325325-xw7627x9 92 24 - - JJ cord-325325-xw7627x9 92 25 organ organ JJ cord-325325-xw7627x9 92 26 failure failure NN cord-325325-xw7627x9 92 27 with with IN cord-325325-xw7627x9 92 28 renal renal JJ cord-325325-xw7627x9 92 29 dysfunction dysfunction NN cord-325325-xw7627x9 92 30 , , , cord-325325-xw7627x9 92 31 and and CC cord-325325-xw7627x9 92 32 sepsis sepsis NN cord-325325-xw7627x9 92 33 . . . cord-325325-xw7627x9 93 1 Most Most JJS cord-325325-xw7627x9 93 2 deaths death NNS cord-325325-xw7627x9 93 3 have have VBP cord-325325-xw7627x9 93 4 been be VBN cord-325325-xw7627x9 93 5 related relate VBN cord-325325-xw7627x9 93 6 to to IN cord-325325-xw7627x9 93 7 respiratory respiratory JJ cord-325325-xw7627x9 93 8 failure failure NN cord-325325-xw7627x9 93 9 . . . cord-325325-xw7627x9 94 1 23 23 CD cord-325325-xw7627x9 95 1 The the DT cord-325325-xw7627x9 95 2 spectrum spectrum NN cord-325325-xw7627x9 95 3 of of IN cord-325325-xw7627x9 95 4 disease disease NN cord-325325-xw7627x9 95 5 is be VBZ cord-325325-xw7627x9 95 6 wide wide JJ cord-325325-xw7627x9 95 7 . . . cord-325325-xw7627x9 96 1 Two two CD cord-325325-xw7627x9 96 2 children child NNS cord-325325-xw7627x9 96 3 from from IN cord-325325-xw7627x9 96 4 the the DT cord-325325-xw7627x9 96 5 same same JJ cord-325325-xw7627x9 96 6 family family NN cord-325325-xw7627x9 96 7 in in IN cord-325325-xw7627x9 96 8 Vietnam Vietnam NNP cord-325325-xw7627x9 96 9 presented present VBD cord-325325-xw7627x9 96 10 with with IN cord-325325-xw7627x9 96 11 diarrhea diarrhea NN cord-325325-xw7627x9 96 12 and and CC cord-325325-xw7627x9 96 13 encephalopathy encephalopathy NN cord-325325-xw7627x9 96 14 , , , cord-325325-xw7627x9 96 15 without without IN cord-325325-xw7627x9 96 16 any any DT cord-325325-xw7627x9 96 17 signs sign NNS cord-325325-xw7627x9 96 18 of of IN cord-325325-xw7627x9 96 19 respiratory respiratory JJ cord-325325-xw7627x9 96 20 compromise compromise NN cord-325325-xw7627x9 96 21 . . . cord-325325-xw7627x9 97 1 34 34 CD cord-325325-xw7627x9 97 2 , , , cord-325325-xw7627x9 97 3 35 35 CD cord-325325-xw7627x9 97 4 The the DT cord-325325-xw7627x9 97 5 incubation incubation NN cord-325325-xw7627x9 97 6 period period NN cord-325325-xw7627x9 97 7 for for IN cord-325325-xw7627x9 97 8 H5N1 H5N1 NNP cord-325325-xw7627x9 97 9 may may MD cord-325325-xw7627x9 97 10 be be VB cord-325325-xw7627x9 97 11 longer long JJR cord-325325-xw7627x9 97 12 than than IN cord-325325-xw7627x9 97 13 other other JJ cord-325325-xw7627x9 97 14 known know VBN cord-325325-xw7627x9 97 15 human human JJ cord-325325-xw7627x9 97 16 influenza influenza NN cord-325325-xw7627x9 97 17 viruses virus NNS cord-325325-xw7627x9 97 18 . . . cord-325325-xw7627x9 98 1 23 23 CD cord-325325-xw7627x9 99 1 In in IN cord-325325-xw7627x9 99 2 1997 1997 CD cord-325325-xw7627x9 99 3 , , , cord-325325-xw7627x9 99 4 most most JJS cord-325325-xw7627x9 99 5 cases case NNS cord-325325-xw7627x9 99 6 occurred occur VBD cord-325325-xw7627x9 99 7 within within IN cord-325325-xw7627x9 99 8 two two CD cord-325325-xw7627x9 99 9 to to TO cord-325325-xw7627x9 99 10 four four CD cord-325325-xw7627x9 99 11 days day NNS cord-325325-xw7627x9 99 12 after after IN cord-325325-xw7627x9 99 13 exposure exposure NN cord-325325-xw7627x9 99 14 , , , cord-325325-xw7627x9 99 15 while while IN cord-325325-xw7627x9 99 16 reports report NNS cord-325325-xw7627x9 99 17 of of IN cord-325325-xw7627x9 99 18 cases case NNS cord-325325-xw7627x9 99 19 from from IN cord-325325-xw7627x9 99 20 2004 2004 CD cord-325325-xw7627x9 99 21 suggest suggest VBP cord-325325-xw7627x9 99 22 that that IN cord-325325-xw7627x9 99 23 longer long JJR cord-325325-xw7627x9 99 24 intervals interval NNS cord-325325-xw7627x9 99 25 of of IN cord-325325-xw7627x9 99 26 up up IN cord-325325-xw7627x9 99 27 to to TO cord-325325-xw7627x9 99 28 eight eight CD cord-325325-xw7627x9 99 29 days day NNS cord-325325-xw7627x9 99 30 may may MD cord-325325-xw7627x9 99 31 be be VB cord-325325-xw7627x9 99 32 possible possible JJ cord-325325-xw7627x9 99 33 . . . cord-325325-xw7627x9 100 1 16 16 CD cord-325325-xw7627x9 100 2 , , , cord-325325-xw7627x9 100 3 36 36 CD cord-325325-xw7627x9 100 4 Diagnosis diagnosis NN cord-325325-xw7627x9 100 5 Diagnosis diagnosis NN cord-325325-xw7627x9 100 6 can can MD cord-325325-xw7627x9 100 7 be be VB cord-325325-xw7627x9 100 8 made make VBN cord-325325-xw7627x9 100 9 with with IN cord-325325-xw7627x9 100 10 clinical clinical JJ cord-325325-xw7627x9 100 11 findings finding NNS cord-325325-xw7627x9 100 12 , , , cord-325325-xw7627x9 100 13 plus plus CC cord-325325-xw7627x9 100 14 recent recent JJ cord-325325-xw7627x9 100 15 history history NN cord-325325-xw7627x9 100 16 of of IN cord-325325-xw7627x9 100 17 exposure exposure NN cord-325325-xw7627x9 100 18 to to IN cord-325325-xw7627x9 100 19 dead dead JJ cord-325325-xw7627x9 100 20 or or CC cord-325325-xw7627x9 100 21 ill ill JJ cord-325325-xw7627x9 100 22 poultry poultry NN cord-325325-xw7627x9 100 23 , , , cord-325325-xw7627x9 100 24 and and CC cord-325325-xw7627x9 100 25 can can MD cord-325325-xw7627x9 100 26 be be VB cord-325325-xw7627x9 100 27 confirmed confirm VBN cord-325325-xw7627x9 100 28 with with IN cord-325325-xw7627x9 100 29 serologic serologic JJ cord-325325-xw7627x9 100 30 tests test NNS cord-325325-xw7627x9 100 31 . . . cord-325325-xw7627x9 101 1 Travel travel NN cord-325325-xw7627x9 101 2 history history NN cord-325325-xw7627x9 101 3 is be VBZ cord-325325-xw7627x9 101 4 also also RB cord-325325-xw7627x9 101 5 very very RB cord-325325-xw7627x9 101 6 important important JJ cord-325325-xw7627x9 101 7 . . . cord-325325-xw7627x9 102 1 Rapid rapid JJ cord-325325-xw7627x9 102 2 antigenic antigenic JJ cord-325325-xw7627x9 102 3 testing testing NN cord-325325-xw7627x9 102 4 kits kit NNS cord-325325-xw7627x9 102 5 are be VBP cord-325325-xw7627x9 102 6 not not RB cord-325325-xw7627x9 102 7 able able JJ cord-325325-xw7627x9 102 8 to to TO cord-325325-xw7627x9 102 9 subtype subtype NN cord-325325-xw7627x9 102 10 influenza influenza NN cord-325325-xw7627x9 102 11 A A NNP cord-325325-xw7627x9 102 12 , , , cord-325325-xw7627x9 102 13 and and CC cord-325325-xw7627x9 102 14 the the DT cord-325325-xw7627x9 102 15 standard standard JJ cord-325325-xw7627x9 102 16 serologic serologic NNP cord-325325-xw7627x9 102 17 test test NN cord-325325-xw7627x9 102 18 ( ( -LRB- cord-325325-xw7627x9 102 19 HA HA NNP cord-325325-xw7627x9 102 20 inhibition inhibition NN cord-325325-xw7627x9 102 21 test test NN cord-325325-xw7627x9 102 22 ) ) -RRB- cord-325325-xw7627x9 102 23 is be VBZ cord-325325-xw7627x9 102 24 insensitive insensitive JJ cord-325325-xw7627x9 102 25 . . . cord-325325-xw7627x9 103 1 [ [ -LRB- cord-325325-xw7627x9 103 2 23 23 CD cord-325325-xw7627x9 103 3 ] ] -RRB- cord-325325-xw7627x9 103 4 [ [ -LRB- cord-325325-xw7627x9 103 5 24 24 CD cord-325325-xw7627x9 103 6 ] ] -RRB- cord-325325-xw7627x9 104 1 [ [ -LRB- cord-325325-xw7627x9 104 2 25 25 CD cord-325325-xw7627x9 104 3 ] ] -RRB- cord-325325-xw7627x9 104 4 [ [ -LRB- cord-325325-xw7627x9 104 5 26 26 CD cord-325325-xw7627x9 104 6 ] ] -RRB- cord-325325-xw7627x9 104 7 [ [ -LRB- cord-325325-xw7627x9 104 8 27 27 CD cord-325325-xw7627x9 104 9 ] ] -RRB- cord-325325-xw7627x9 105 1 [ [ -LRB- cord-325325-xw7627x9 105 2 28 28 CD cord-325325-xw7627x9 105 3 ] ] -RRB- cord-325325-xw7627x9 106 1 [ [ -LRB- cord-325325-xw7627x9 106 2 29 29 CD cord-325325-xw7627x9 106 3 ] ] -RRB- cord-325325-xw7627x9 107 1 [ [ -LRB- cord-325325-xw7627x9 107 2 30 30 CD cord-325325-xw7627x9 107 3 ] ] -RRB- cord-325325-xw7627x9 107 4 [ [ -LRB- cord-325325-xw7627x9 107 5 31 31 CD cord-325325-xw7627x9 107 6 ] ] -RRB- cord-325325-xw7627x9 108 1 [ [ -LRB- cord-325325-xw7627x9 108 2 32 32 CD cord-325325-xw7627x9 108 3 ] ] -RRB- cord-325325-xw7627x9 108 4 [ [ -LRB- cord-325325-xw7627x9 108 5 33 33 CD cord-325325-xw7627x9 108 6 ] ] -RRB- cord-325325-xw7627x9 108 7 [ [ -LRB- cord-325325-xw7627x9 108 8 34 34 CD cord-325325-xw7627x9 108 9 ] ] -RRB- cord-325325-xw7627x9 109 1 [ [ -LRB- cord-325325-xw7627x9 109 2 35 35 CD cord-325325-xw7627x9 109 3 ] ] -RRB- cord-325325-xw7627x9 109 4 [ [ -LRB- cord-325325-xw7627x9 109 5 36 36 CD cord-325325-xw7627x9 109 6 ] ] -RRB- cord-325325-xw7627x9 110 1 Diagnosis diagnosis NN cord-325325-xw7627x9 110 2 can can MD cord-325325-xw7627x9 110 3 be be VB cord-325325-xw7627x9 110 4 confirmed confirm VBN cord-325325-xw7627x9 110 5 by by IN cord-325325-xw7627x9 110 6 HAspecific HAspecific NNP cord-325325-xw7627x9 110 7 PCR PCR NNP cord-325325-xw7627x9 110 8 assay assay NN cord-325325-xw7627x9 110 9 or or CC cord-325325-xw7627x9 110 10 by by IN cord-325325-xw7627x9 110 11 viral viral JJ cord-325325-xw7627x9 110 12 culture culture NN cord-325325-xw7627x9 110 13 of of IN cord-325325-xw7627x9 110 14 a a DT cord-325325-xw7627x9 110 15 nasopharyngeal nasopharyngeal JJ cord-325325-xw7627x9 110 16 aspirate aspirate NN cord-325325-xw7627x9 110 17 obtained obtain VBN cord-325325-xw7627x9 110 18 within within IN cord-325325-xw7627x9 110 19 three three CD cord-325325-xw7627x9 110 20 days day NNS cord-325325-xw7627x9 110 21 of of IN cord-325325-xw7627x9 110 22 the the DT cord-325325-xw7627x9 110 23 onset onset NN cord-325325-xw7627x9 110 24 of of IN cord-325325-xw7627x9 110 25 symptoms symptom NNS cord-325325-xw7627x9 110 26 . . . cord-325325-xw7627x9 111 1 23 23 CD cord-325325-xw7627x9 111 2 ELISA ELISA NNP cord-325325-xw7627x9 111 3 and and CC cord-325325-xw7627x9 111 4 western western JJ cord-325325-xw7627x9 111 5 blotting blotting NN cord-325325-xw7627x9 111 6 are be VBP cord-325325-xw7627x9 111 7 useful useful JJ cord-325325-xw7627x9 111 8 for for IN cord-325325-xw7627x9 111 9 epidemiologic epidemiologic JJ cord-325325-xw7627x9 111 10 surveillance surveillance NN cord-325325-xw7627x9 111 11 studies study NNS cord-325325-xw7627x9 111 12 and and CC cord-325325-xw7627x9 111 13 retrospective retrospective JJ cord-325325-xw7627x9 111 14 diagnosis diagnosis NN cord-325325-xw7627x9 111 15 . . . cord-325325-xw7627x9 112 1 37 37 CD cord-325325-xw7627x9 112 2 Radiologic radiologic JJ cord-325325-xw7627x9 112 3 findings finding NNS cord-325325-xw7627x9 112 4 include include VBP cord-325325-xw7627x9 112 5 diffuse diffuse JJ cord-325325-xw7627x9 112 6 , , , cord-325325-xw7627x9 112 7 multi multi JJ cord-325325-xw7627x9 112 8 - - JJ cord-325325-xw7627x9 112 9 focal focal JJ cord-325325-xw7627x9 112 10 or or CC cord-325325-xw7627x9 112 11 patchy patchy JJ cord-325325-xw7627x9 112 12 infiltrates infiltrate NNS cord-325325-xw7627x9 112 13 and and CC cord-325325-xw7627x9 112 14 segmental segmental JJ cord-325325-xw7627x9 112 15 or or CC cord-325325-xw7627x9 112 16 lobar lobar JJ cord-325325-xw7627x9 112 17 consolidation consolidation NN cord-325325-xw7627x9 112 18 with with IN cord-325325-xw7627x9 112 19 air air NNP cord-325325-xw7627x9 112 20 bronchograms bronchograms NNP cord-325325-xw7627x9 112 21 . . . cord-325325-xw7627x9 113 1 36 36 CD cord-325325-xw7627x9 114 1 The the DT cord-325325-xw7627x9 114 2 differential differential JJ cord-325325-xw7627x9 114 3 diagnoses diagnosis NNS cord-325325-xw7627x9 114 4 of of IN cord-325325-xw7627x9 114 5 avian avian JJ cord-325325-xw7627x9 114 6 influenza influenza NN cord-325325-xw7627x9 114 7 include include VBP cord-325325-xw7627x9 114 8 atypical atypical JJ cord-325325-xw7627x9 114 9 pneumonia pneumonia NN cord-325325-xw7627x9 114 10 , , , cord-325325-xw7627x9 114 11 human human JJ cord-325325-xw7627x9 114 12 influenza influenza NN cord-325325-xw7627x9 114 13 , , , cord-325325-xw7627x9 114 14 respiratory respiratory JJ cord-325325-xw7627x9 114 15 syncytial syncytial JJ cord-325325-xw7627x9 114 16 virus virus NN cord-325325-xw7627x9 114 17 , , , cord-325325-xw7627x9 114 18 severe severe JJ cord-325325-xw7627x9 114 19 acute acute JJ cord-325325-xw7627x9 114 20 respiratory respiratory JJ cord-325325-xw7627x9 114 21 syndrome syndrome NN cord-325325-xw7627x9 114 22 ( ( -LRB- cord-325325-xw7627x9 114 23 SARS SARS NNP cord-325325-xw7627x9 114 24 ) ) -RRB- cord-325325-xw7627x9 114 25 , , , cord-325325-xw7627x9 114 26 and and CC cord-325325-xw7627x9 114 27 upper upper JJ cord-325325-xw7627x9 114 28 respiratory respiratory JJ cord-325325-xw7627x9 114 29 tract tract NN cord-325325-xw7627x9 114 30 infections infection NNS cord-325325-xw7627x9 114 31 associated associate VBN cord-325325-xw7627x9 114 32 with with IN cord-325325-xw7627x9 114 33 conjunctivitis conjunctivitis NN cord-325325-xw7627x9 114 34 ( ( -LRB- cord-325325-xw7627x9 114 35 e.g. e.g. RB cord-325325-xw7627x9 114 36 , , , cord-325325-xw7627x9 114 37 adenovirus adenovirus NN cord-325325-xw7627x9 114 38 ) ) -RRB- cord-325325-xw7627x9 114 39 . . . cord-325325-xw7627x9 115 1 High high JJ cord-325325-xw7627x9 115 2 - - HYPH cord-325325-xw7627x9 115 3 risk risk NN cord-325325-xw7627x9 115 4 individuals individual NNS cord-325325-xw7627x9 115 5 , , , cord-325325-xw7627x9 115 6 such such JJ cord-325325-xw7627x9 115 7 as as IN cord-325325-xw7627x9 115 8 patients patient NNS cord-325325-xw7627x9 115 9 with with IN cord-325325-xw7627x9 115 10 a a DT cord-325325-xw7627x9 115 11 history history NN cord-325325-xw7627x9 115 12 of of IN cord-325325-xw7627x9 115 13 travel travel NN cord-325325-xw7627x9 115 14 within within IN cord-325325-xw7627x9 115 15 10 10 CD cord-325325-xw7627x9 115 16 days day NNS cord-325325-xw7627x9 115 17 of of IN cord-325325-xw7627x9 115 18 symptom symptom NN cord-325325-xw7627x9 115 19 onset onset NN cord-325325-xw7627x9 115 20 to to IN cord-325325-xw7627x9 115 21 a a DT cord-325325-xw7627x9 115 22 country country NN cord-325325-xw7627x9 115 23 with with IN cord-325325-xw7627x9 115 24 documented document VBN cord-325325-xw7627x9 115 25 H5N1 H5N1 NNP cord-325325-xw7627x9 115 26 avian avian JJ cord-325325-xw7627x9 115 27 influenza influenza NN cord-325325-xw7627x9 115 28 in in IN cord-325325-xw7627x9 115 29 poultry poultry NN cord-325325-xw7627x9 115 30 and/or and/or CC cord-325325-xw7627x9 115 31 humans human NNS cord-325325-xw7627x9 115 32 , , , cord-325325-xw7627x9 115 33 and and CC cord-325325-xw7627x9 115 34 patients patient NNS cord-325325-xw7627x9 115 35 who who WP cord-325325-xw7627x9 115 36 have have VBP cord-325325-xw7627x9 115 37 radiographically radiographically RB cord-325325-xw7627x9 115 38 confirmed confirm VBN cord-325325-xw7627x9 115 39 pneumonia pneumonia NN cord-325325-xw7627x9 115 40 , , , cord-325325-xw7627x9 115 41 ARDS ARDS NNP cord-325325-xw7627x9 115 42 , , , cord-325325-xw7627x9 115 43 or or CC cord-325325-xw7627x9 115 44 any any DT cord-325325-xw7627x9 115 45 other other JJ cord-325325-xw7627x9 115 46 severe severe JJ cord-325325-xw7627x9 115 47 respiratory respiratory JJ cord-325325-xw7627x9 115 48 illness illness NN cord-325325-xw7627x9 115 49 for for IN cord-325325-xw7627x9 115 50 which which WDT cord-325325-xw7627x9 115 51 an an DT cord-325325-xw7627x9 115 52 alternate alternate JJ cord-325325-xw7627x9 115 53 etiology etiology NN cord-325325-xw7627x9 115 54 has have VBZ cord-325325-xw7627x9 115 55 not not RB cord-325325-xw7627x9 115 56 been be VBN cord-325325-xw7627x9 115 57 established establish VBN cord-325325-xw7627x9 115 58 , , , cord-325325-xw7627x9 115 59 should should MD cord-325325-xw7627x9 115 60 be be VB cord-325325-xw7627x9 115 61 tested test VBN cord-325325-xw7627x9 115 62 . . . cord-325325-xw7627x9 116 1 For for IN cord-325325-xw7627x9 116 2 low low JJ cord-325325-xw7627x9 116 3 - - HYPH cord-325325-xw7627x9 116 4 risk risk NN cord-325325-xw7627x9 116 5 individuals individual NNS cord-325325-xw7627x9 116 6 , , , cord-325325-xw7627x9 116 7 testing testing NN cord-325325-xw7627x9 116 8 should should MD cord-325325-xw7627x9 116 9 be be VB cord-325325-xw7627x9 116 10 considered consider VBN cord-325325-xw7627x9 116 11 in in IN cord-325325-xw7627x9 116 12 patients patient NNS cord-325325-xw7627x9 116 13 with with IN cord-325325-xw7627x9 116 14 a a DT cord-325325-xw7627x9 116 15 history history NN cord-325325-xw7627x9 116 16 of of IN cord-325325-xw7627x9 116 17 contact contact NN cord-325325-xw7627x9 116 18 with with IN cord-325325-xw7627x9 116 19 domestic domestic JJ cord-325325-xw7627x9 116 20 poultry poultry NN cord-325325-xw7627x9 116 21 or or CC cord-325325-xw7627x9 116 22 with with IN cord-325325-xw7627x9 116 23 a a DT cord-325325-xw7627x9 116 24 known know VBN cord-325325-xw7627x9 116 25 or or CC cord-325325-xw7627x9 116 26 suspected suspect VBN cord-325325-xw7627x9 116 27 human human JJ cord-325325-xw7627x9 116 28 case case NN cord-325325-xw7627x9 116 29 in in IN cord-325325-xw7627x9 116 30 an an DT cord-325325-xw7627x9 116 31 H5N1-affected h5n1-affecte VBN cord-325325-xw7627x9 116 32 country country NN cord-325325-xw7627x9 116 33 within within IN cord-325325-xw7627x9 116 34 10 10 CD cord-325325-xw7627x9 116 35 days day NNS cord-325325-xw7627x9 116 36 of of IN cord-325325-xw7627x9 116 37 symptom symptom NN cord-325325-xw7627x9 116 38 onset onset NN cord-325325-xw7627x9 116 39 , , , cord-325325-xw7627x9 116 40 documented document VBN cord-325325-xw7627x9 116 41 fever fever NN cord-325325-xw7627x9 116 42 of of IN cord-325325-xw7627x9 116 43 38 38 CD cord-325325-xw7627x9 116 44 8C 8c CD cord-325325-xw7627x9 116 45 , , , cord-325325-xw7627x9 116 46 and and CC cord-325325-xw7627x9 116 47 one one CD cord-325325-xw7627x9 116 48 or or CC cord-325325-xw7627x9 116 49 more more JJR cord-325325-xw7627x9 116 50 of of IN cord-325325-xw7627x9 116 51 the the DT cord-325325-xw7627x9 116 52 following following NN cord-325325-xw7627x9 116 53 : : : cord-325325-xw7627x9 116 54 cough cough NN cord-325325-xw7627x9 116 55 , , , cord-325325-xw7627x9 116 56 sore sore JJ cord-325325-xw7627x9 116 57 throat throat NN cord-325325-xw7627x9 116 58 , , , cord-325325-xw7627x9 116 59 shortness shortness NN cord-325325-xw7627x9 116 60 of of IN cord-325325-xw7627x9 116 61 breath breath NN cord-325325-xw7627x9 116 62 . . . cord-325325-xw7627x9 117 1 23 23 CD cord-325325-xw7627x9 117 2 , , , cord-325325-xw7627x9 117 3 36 36 CD cord-325325-xw7627x9 117 4 Treatment treatment NN cord-325325-xw7627x9 118 1 Whenever whenever WRB cord-325325-xw7627x9 118 2 feasible feasible JJ cord-325325-xw7627x9 118 3 , , , cord-325325-xw7627x9 118 4 while while IN cord-325325-xw7627x9 118 5 the the DT cord-325325-xw7627x9 118 6 number number NN cord-325325-xw7627x9 118 7 of of IN cord-325325-xw7627x9 118 8 affected affect VBN cord-325325-xw7627x9 118 9 persons person NNS cord-325325-xw7627x9 118 10 is be VBZ cord-325325-xw7627x9 118 11 small small JJ cord-325325-xw7627x9 118 12 , , , cord-325325-xw7627x9 118 13 patients patient NNS cord-325325-xw7627x9 118 14 with with IN cord-325325-xw7627x9 118 15 suspected suspect VBN cord-325325-xw7627x9 118 16 or or CC cord-325325-xw7627x9 118 17 proven prove VBN cord-325325-xw7627x9 118 18 influenza influenza NN cord-325325-xw7627x9 118 19 A a NN cord-325325-xw7627x9 118 20 ( ( -LRB- cord-325325-xw7627x9 118 21 H5N1 H5N1 NNP cord-325325-xw7627x9 118 22 ) ) -RRB- cord-325325-xw7627x9 118 23 infection infection NN cord-325325-xw7627x9 118 24 should should MD cord-325325-xw7627x9 118 25 be be VB cord-325325-xw7627x9 118 26 hospitalized hospitalize VBN cord-325325-xw7627x9 118 27 in in IN cord-325325-xw7627x9 118 28 isolation isolation NN cord-325325-xw7627x9 118 29 for for IN cord-325325-xw7627x9 118 30 clinical clinical JJ cord-325325-xw7627x9 118 31 monitoring monitoring NN cord-325325-xw7627x9 118 32 , , , cord-325325-xw7627x9 118 33 appropriate appropriate JJ cord-325325-xw7627x9 118 34 diagnostic diagnostic JJ cord-325325-xw7627x9 118 35 testing testing NN cord-325325-xw7627x9 118 36 , , , cord-325325-xw7627x9 118 37 and and CC cord-325325-xw7627x9 118 38 antiviral antiviral JJ cord-325325-xw7627x9 118 39 therapy therapy NN cord-325325-xw7627x9 118 40 . . . cord-325325-xw7627x9 119 1 38 38 CD cord-325325-xw7627x9 120 1 The the DT cord-325325-xw7627x9 120 2 majority majority NN cord-325325-xw7627x9 120 3 of of IN cord-325325-xw7627x9 120 4 H5N1 H5N1 NNP cord-325325-xw7627x9 120 5 isolates isolate NNS cord-325325-xw7627x9 120 6 are be VBP cord-325325-xw7627x9 120 7 still still RB cord-325325-xw7627x9 120 8 sensitive sensitive JJ cord-325325-xw7627x9 120 9 to to IN cord-325325-xw7627x9 120 10 amantadine amantadine NNP cord-325325-xw7627x9 120 11 . . . cord-325325-xw7627x9 121 1 However however RB cord-325325-xw7627x9 121 2 , , , cord-325325-xw7627x9 121 3 more more RBR cord-325325-xw7627x9 121 4 recent recent JJ cord-325325-xw7627x9 121 5 viruses virus NNS cord-325325-xw7627x9 121 6 isolated isolate VBN cord-325325-xw7627x9 121 7 in in IN cord-325325-xw7627x9 121 8 Thailand Thailand NNP cord-325325-xw7627x9 121 9 and and CC cord-325325-xw7627x9 121 10 Vietnam Vietnam NNP cord-325325-xw7627x9 121 11 have have VBP cord-325325-xw7627x9 121 12 amino amino NN cord-325325-xw7627x9 121 13 acid acid NN cord-325325-xw7627x9 121 14 substitutions substitution NNS cord-325325-xw7627x9 121 15 within within IN cord-325325-xw7627x9 121 16 the the DT cord-325325-xw7627x9 121 17 M2 M2 NNP cord-325325-xw7627x9 121 18 protein protein NN cord-325325-xw7627x9 121 19 , , , cord-325325-xw7627x9 121 20 which which WDT cord-325325-xw7627x9 121 21 confer confer VBP cord-325325-xw7627x9 121 22 resistance resistance NN cord-325325-xw7627x9 121 23 to to IN cord-325325-xw7627x9 121 24 amantadine amantadine NNP cord-325325-xw7627x9 121 25 and and CC cord-325325-xw7627x9 121 26 rimantadine rimantadine NNP cord-325325-xw7627x9 121 27 . . . cord-325325-xw7627x9 122 1 39 39 CD cord-325325-xw7627x9 122 2 , , , cord-325325-xw7627x9 122 3 40 40 CD cord-325325-xw7627x9 122 4 These these DT cord-325325-xw7627x9 122 5 viruses virus NNS cord-325325-xw7627x9 122 6 are be VBP cord-325325-xw7627x9 122 7 susceptible susceptible JJ cord-325325-xw7627x9 122 8 to to IN cord-325325-xw7627x9 122 9 the the DT cord-325325-xw7627x9 122 10 neuraminidase neuraminidase NN cord-325325-xw7627x9 122 11 inhibitors inhibitor NNS cord-325325-xw7627x9 122 12 in in IN cord-325325-xw7627x9 122 13 animal animal NN cord-325325-xw7627x9 122 14 models model NNS cord-325325-xw7627x9 122 15 . . . cord-325325-xw7627x9 123 1 41 41 CD cord-325325-xw7627x9 123 2 Oseltamivir Oseltamivir NNP cord-325325-xw7627x9 123 3 should should MD cord-325325-xw7627x9 123 4 be be VB cord-325325-xw7627x9 123 5 started start VBN cord-325325-xw7627x9 123 6 as as RB cord-325325-xw7627x9 123 7 soon soon RB cord-325325-xw7627x9 123 8 as as IN cord-325325-xw7627x9 123 9 possible possible JJ cord-325325-xw7627x9 123 10 . . . cord-325325-xw7627x9 124 1 In in IN cord-325325-xw7627x9 124 2 an an DT cord-325325-xw7627x9 124 3 animal animal NN cord-325325-xw7627x9 124 4 study study NN cord-325325-xw7627x9 124 5 where where WRB cord-325325-xw7627x9 124 6 mice mouse NNS cord-325325-xw7627x9 124 7 were be VBD cord-325325-xw7627x9 124 8 inoculated inoculate VBN cord-325325-xw7627x9 124 9 with with IN cord-325325-xw7627x9 124 10 H5N1 H5N1 NNP cord-325325-xw7627x9 124 11 virus virus NN cord-325325-xw7627x9 124 12 isolated isolate VBN cord-325325-xw7627x9 124 13 from from IN cord-325325-xw7627x9 124 14 a a DT cord-325325-xw7627x9 124 15 patient patient NN cord-325325-xw7627x9 124 16 who who WP cord-325325-xw7627x9 124 17 did do VBD cord-325325-xw7627x9 124 18 not not RB cord-325325-xw7627x9 124 19 survive survive VB cord-325325-xw7627x9 124 20 the the DT cord-325325-xw7627x9 124 21 infection infection NN cord-325325-xw7627x9 124 22 , , , cord-325325-xw7627x9 124 23 the the DT cord-325325-xw7627x9 124 24 mice mouse NNS cord-325325-xw7627x9 124 25 that that WDT cord-325325-xw7627x9 124 26 were be VBD cord-325325-xw7627x9 124 27 treated treat VBN cord-325325-xw7627x9 124 28 for for IN cord-325325-xw7627x9 124 29 eight eight CD cord-325325-xw7627x9 124 30 days day NNS cord-325325-xw7627x9 124 31 with with IN cord-325325-xw7627x9 124 32 oseltamivir oseltamivir NNP cord-325325-xw7627x9 124 33 had have VBD cord-325325-xw7627x9 124 34 significantly significantly RB cord-325325-xw7627x9 124 35 better well JJR cord-325325-xw7627x9 124 36 survival survival NN cord-325325-xw7627x9 124 37 rates rate NNS cord-325325-xw7627x9 124 38 in in IN cord-325325-xw7627x9 124 39 all all DT cord-325325-xw7627x9 124 40 dose dose NN cord-325325-xw7627x9 124 41 ranges range NNS cord-325325-xw7627x9 124 42 when when WRB cord-325325-xw7627x9 124 43 compared compare VBN cord-325325-xw7627x9 124 44 to to IN cord-325325-xw7627x9 124 45 animals animal NNS cord-325325-xw7627x9 124 46 that that WDT cord-325325-xw7627x9 124 47 were be VBD cord-325325-xw7627x9 124 48 treated treat VBN cord-325325-xw7627x9 124 49 for for IN cord-325325-xw7627x9 124 50 only only RB cord-325325-xw7627x9 124 51 five five CD cord-325325-xw7627x9 124 52 days day NNS cord-325325-xw7627x9 124 53 . . . cord-325325-xw7627x9 125 1 39 39 CD cord-325325-xw7627x9 125 2 Prior Prior NNP cord-325325-xw7627x9 125 3 animal animal NN cord-325325-xw7627x9 125 4 studies study NNS cord-325325-xw7627x9 125 5 demonstrated demonstrate VBD cord-325325-xw7627x9 125 6 that that IN cord-325325-xw7627x9 125 7 five five CD cord-325325-xw7627x9 125 8 days day NNS cord-325325-xw7627x9 125 9 of of IN cord-325325-xw7627x9 125 10 oseltamivir oseltamivir NN cord-325325-xw7627x9 125 11 was be VBD cord-325325-xw7627x9 125 12 effective effective JJ cord-325325-xw7627x9 125 13 against against IN cord-325325-xw7627x9 125 14 another another DT cord-325325-xw7627x9 125 15 H5N1 H5N1 NNP cord-325325-xw7627x9 125 16 variant variant NN cord-325325-xw7627x9 125 17 . . . cord-325325-xw7627x9 126 1 42 42 CD cord-325325-xw7627x9 127 1 Thus thus RB cord-325325-xw7627x9 127 2 , , , cord-325325-xw7627x9 127 3 treatment treatment NN cord-325325-xw7627x9 127 4 dose dose NN cord-325325-xw7627x9 127 5 and and CC cord-325325-xw7627x9 127 6 duration duration NN cord-325325-xw7627x9 127 7 may may MD cord-325325-xw7627x9 127 8 vary vary VB cord-325325-xw7627x9 127 9 according accord VBG cord-325325-xw7627x9 127 10 to to IN cord-325325-xw7627x9 127 11 the the DT cord-325325-xw7627x9 127 12 pathogenicity pathogenicity NN cord-325325-xw7627x9 127 13 and and CC cord-325325-xw7627x9 127 14 virulence virulence NN cord-325325-xw7627x9 127 15 of of IN cord-325325-xw7627x9 127 16 the the DT cord-325325-xw7627x9 127 17 virus virus NN cord-325325-xw7627x9 127 18 . . . cord-325325-xw7627x9 128 1 39 39 CD cord-325325-xw7627x9 129 1 An an DT cord-325325-xw7627x9 129 2 oseltamivir oseltamivir NN cord-325325-xw7627x9 129 3 - - HYPH cord-325325-xw7627x9 129 4 resistant resistant JJ cord-325325-xw7627x9 129 5 H5N1 H5N1 NNP cord-325325-xw7627x9 129 6 strain strain NN cord-325325-xw7627x9 129 7 ( ( -LRB- cord-325325-xw7627x9 129 8 His274Tyr his274tyr NN cord-325325-xw7627x9 129 9 ) ) -RRB- cord-325325-xw7627x9 129 10 has have VBZ cord-325325-xw7627x9 129 11 been be VBN cord-325325-xw7627x9 129 12 reported report VBN cord-325325-xw7627x9 129 13 in in IN cord-325325-xw7627x9 129 14 two two CD cord-325325-xw7627x9 129 15 cases case NNS cord-325325-xw7627x9 129 16 in in IN cord-325325-xw7627x9 129 17 Vietnam Vietnam NNP cord-325325-xw7627x9 129 18 . . . cord-325325-xw7627x9 130 1 Both both DT cord-325325-xw7627x9 130 2 patients patient NNS cord-325325-xw7627x9 130 3 died die VBD cord-325325-xw7627x9 130 4 of of IN cord-325325-xw7627x9 130 5 the the DT cord-325325-xw7627x9 130 6 infection infection NN cord-325325-xw7627x9 130 7 despite despite IN cord-325325-xw7627x9 130 8 early early JJ cord-325325-xw7627x9 130 9 initiation initiation NN cord-325325-xw7627x9 130 10 of of IN cord-325325-xw7627x9 130 11 treatment treatment NN cord-325325-xw7627x9 130 12 in in IN cord-325325-xw7627x9 130 13 one one CD cord-325325-xw7627x9 130 14 case case NN cord-325325-xw7627x9 130 15 and and CC cord-325325-xw7627x9 130 16 proper proper JJ cord-325325-xw7627x9 130 17 dosage dosage NN cord-325325-xw7627x9 130 18 ( ( -LRB- cord-325325-xw7627x9 130 19 75 75 CD cord-325325-xw7627x9 130 20 mg mg NN cord-325325-xw7627x9 130 21 twice twice RB cord-325325-xw7627x9 130 22 daily daily RB cord-325325-xw7627x9 130 23 ) ) -RRB- cord-325325-xw7627x9 130 24 in in IN cord-325325-xw7627x9 130 25 both both DT cord-325325-xw7627x9 130 26 cases case NNS cord-325325-xw7627x9 130 27 . . . cord-325325-xw7627x9 131 1 Therefore therefore RB cord-325325-xw7627x9 131 2 , , , cord-325325-xw7627x9 131 3 the the DT cord-325325-xw7627x9 131 4 use use NN cord-325325-xw7627x9 131 5 of of IN cord-325325-xw7627x9 131 6 higher high JJR cord-325325-xw7627x9 131 7 doses dose NNS cord-325325-xw7627x9 131 8 , , , cord-325325-xw7627x9 131 9 longer long JJR cord-325325-xw7627x9 131 10 durations duration NNS cord-325325-xw7627x9 131 11 of of IN cord-325325-xw7627x9 131 12 treatment treatment NN cord-325325-xw7627x9 131 13 , , , cord-325325-xw7627x9 131 14 or or CC cord-325325-xw7627x9 131 15 combination combination NN cord-325325-xw7627x9 131 16 therapy therapy NN cord-325325-xw7627x9 131 17 may may MD cord-325325-xw7627x9 131 18 deserve deserve VB cord-325325-xw7627x9 131 19 further further JJ cord-325325-xw7627x9 131 20 evaluation evaluation NN cord-325325-xw7627x9 131 21 . . . cord-325325-xw7627x9 132 1 43 43 CD cord-325325-xw7627x9 132 2 Improper improper JJ cord-325325-xw7627x9 132 3 use use NN cord-325325-xw7627x9 132 4 of of IN cord-325325-xw7627x9 132 5 personal personal JJ cord-325325-xw7627x9 132 6 stockpiles stockpile NNS cord-325325-xw7627x9 132 7 of of IN cord-325325-xw7627x9 132 8 oseltamivir oseltamivir NNS cord-325325-xw7627x9 132 9 may may MD cord-325325-xw7627x9 132 10 promote promote VB cord-325325-xw7627x9 132 11 resistance resistance NN cord-325325-xw7627x9 132 12 and and CC cord-325325-xw7627x9 132 13 should should MD cord-325325-xw7627x9 132 14 be be VB cord-325325-xw7627x9 132 15 strongly strongly RB cord-325325-xw7627x9 132 16 discouraged discourage VBN cord-325325-xw7627x9 132 17 . . . cord-325325-xw7627x9 133 1 44 44 CD cord-325325-xw7627x9 133 2 Zanamivir Zanamivir NNP cord-325325-xw7627x9 133 3 is be VBZ cord-325325-xw7627x9 133 4 another another DT cord-325325-xw7627x9 133 5 neuraminidase neuraminidase NN cord-325325-xw7627x9 133 6 inhibitor inhibitor NN cord-325325-xw7627x9 133 7 , , , cord-325325-xw7627x9 133 8 and and CC cord-325325-xw7627x9 133 9 was be VBD cord-325325-xw7627x9 133 10 the the DT cord-325325-xw7627x9 133 11 first first JJ cord-325325-xw7627x9 133 12 neuraminidase neuraminidase NN cord-325325-xw7627x9 133 13 inhibitor inhibitor NN cord-325325-xw7627x9 133 14 to to TO cord-325325-xw7627x9 133 15 be be VB cord-325325-xw7627x9 133 16 approved approve VBN cord-325325-xw7627x9 133 17 for for IN cord-325325-xw7627x9 133 18 influenza influenza NN cord-325325-xw7627x9 133 19 treatment treatment NN cord-325325-xw7627x9 133 20 . . . cord-325325-xw7627x9 134 1 It -PRON- PRP cord-325325-xw7627x9 134 2 is be VBZ cord-325325-xw7627x9 134 3 also also RB cord-325325-xw7627x9 134 4 recommended recommend VBN cord-325325-xw7627x9 134 5 for for IN cord-325325-xw7627x9 134 6 the the DT cord-325325-xw7627x9 134 7 treatment treatment NN cord-325325-xw7627x9 134 8 of of IN cord-325325-xw7627x9 134 9 H5N1 H5N1 NNP cord-325325-xw7627x9 134 10 infection infection NN cord-325325-xw7627x9 134 11 , , , cord-325325-xw7627x9 134 12 together together RB cord-325325-xw7627x9 134 13 with with IN cord-325325-xw7627x9 134 14 oseltamivir oseltamivir NNP cord-325325-xw7627x9 134 15 . . . cord-325325-xw7627x9 135 1 Corticosteroids corticosteroid NNS cord-325325-xw7627x9 135 2 have have VBP cord-325325-xw7627x9 135 3 been be VBN cord-325325-xw7627x9 135 4 used use VBN cord-325325-xw7627x9 135 5 frequently frequently RB cord-325325-xw7627x9 135 6 in in IN cord-325325-xw7627x9 135 7 treating treat VBG cord-325325-xw7627x9 135 8 patients patient NNS cord-325325-xw7627x9 135 9 with with IN cord-325325-xw7627x9 135 10 H5N1 H5N1 NNP cord-325325-xw7627x9 135 11 infection infection NN cord-325325-xw7627x9 135 12 with with IN cord-325325-xw7627x9 135 13 uncertain uncertain JJ cord-325325-xw7627x9 135 14 effects effect NNS cord-325325-xw7627x9 135 15 . . . cord-325325-xw7627x9 136 1 Other other JJ cord-325325-xw7627x9 136 2 agents agent NNS cord-325325-xw7627x9 136 3 like like IN cord-325325-xw7627x9 136 4 peramivir peramivir NNS cord-325325-xw7627x9 136 5 , , , cord-325325-xw7627x9 136 6 long long RB cord-325325-xw7627x9 136 7 - - HYPH cord-325325-xw7627x9 136 8 acting act VBG cord-325325-xw7627x9 136 9 topical topical JJ cord-325325-xw7627x9 136 10 neuraminidase neuraminidase NN cord-325325-xw7627x9 136 11 inhibitors inhibitor NNS cord-325325-xw7627x9 136 12 , , , cord-325325-xw7627x9 136 13 ribavirin ribavirin NN cord-325325-xw7627x9 136 14 , , , cord-325325-xw7627x9 136 15 45 45 CD cord-325325-xw7627x9 136 16 , , , cord-325325-xw7627x9 136 17 46 46 CD cord-325325-xw7627x9 136 18 and and CC cord-325325-xw7627x9 136 19 possibly possibly RB cord-325325-xw7627x9 136 20 interferon interferon NN cord-325325-xw7627x9 136 21 alpha alpha NN cord-325325-xw7627x9 136 22 , , , cord-325325-xw7627x9 136 23 which which WDT cord-325325-xw7627x9 136 24 has have VBZ cord-325325-xw7627x9 136 25 both both DT cord-325325-xw7627x9 136 26 antiviral antiviral JJ cord-325325-xw7627x9 136 27 and and CC cord-325325-xw7627x9 136 28 immunomodulatory immunomodulatory JJ cord-325325-xw7627x9 136 29 activities activity NNS cord-325325-xw7627x9 136 30 , , , cord-325325-xw7627x9 136 31 are be VBP cord-325325-xw7627x9 136 32 under under IN cord-325325-xw7627x9 136 33 investigation investigation NN cord-325325-xw7627x9 136 34 . . . cord-325325-xw7627x9 137 1 47 47 CD cord-325325-xw7627x9 138 1 According accord VBG cord-325325-xw7627x9 138 2 to to IN cord-325325-xw7627x9 138 3 a a DT cord-325325-xw7627x9 138 4 recent recent JJ cord-325325-xw7627x9 138 5 report report NN cord-325325-xw7627x9 138 6 , , , cord-325325-xw7627x9 138 7 patients patient NNS cord-325325-xw7627x9 138 8 with with IN cord-325325-xw7627x9 138 9 Spanish spanish JJ cord-325325-xw7627x9 138 10 influenza influenza NN cord-325325-xw7627x9 138 11 pneumonia pneumonia NN cord-325325-xw7627x9 138 12 who who WP cord-325325-xw7627x9 138 13 received receive VBD cord-325325-xw7627x9 138 14 influenza influenza NN cord-325325-xw7627x9 138 15 - - HYPH cord-325325-xw7627x9 138 16 convalescent convalescent JJ cord-325325-xw7627x9 138 17 human human JJ cord-325325-xw7627x9 138 18 blood blood NN cord-325325-xw7627x9 138 19 products product NNS cord-325325-xw7627x9 138 20 may may MD cord-325325-xw7627x9 138 21 have have VB cord-325325-xw7627x9 138 22 experienced experience VBN cord-325325-xw7627x9 138 23 a a DT cord-325325-xw7627x9 138 24 clinically clinically RB cord-325325-xw7627x9 138 25 important important JJ cord-325325-xw7627x9 138 26 reduction reduction NN cord-325325-xw7627x9 138 27 in in IN cord-325325-xw7627x9 138 28 the the DT cord-325325-xw7627x9 138 29 risk risk NN cord-325325-xw7627x9 138 30 of of IN cord-325325-xw7627x9 138 31 death death NN cord-325325-xw7627x9 138 32 . . . cord-325325-xw7627x9 139 1 Convalescent convalescent JJ cord-325325-xw7627x9 139 2 human human NN cord-325325-xw7627x9 139 3 H5N1 H5N1 NNP cord-325325-xw7627x9 139 4 plasma plasma NN cord-325325-xw7627x9 139 5 could could MD cord-325325-xw7627x9 139 6 have have VB cord-325325-xw7627x9 139 7 similar similar JJ cord-325325-xw7627x9 139 8 benefits benefit NNS cord-325325-xw7627x9 139 9 and and CC cord-325325-xw7627x9 139 10 should should MD cord-325325-xw7627x9 139 11 be be VB cord-325325-xw7627x9 139 12 studied study VBN cord-325325-xw7627x9 139 13 in in IN cord-325325-xw7627x9 139 14 clinical clinical JJ cord-325325-xw7627x9 139 15 trials trial NNS cord-325325-xw7627x9 139 16 . . . cord-325325-xw7627x9 140 1 48 48 CD cord-325325-xw7627x9 140 2 _SP cord-325325-xw7627x9 141 1 Although although IN cord-325325-xw7627x9 141 2 immunization immunization NN cord-325325-xw7627x9 141 3 with with IN cord-325325-xw7627x9 141 4 human human JJ cord-325325-xw7627x9 141 5 influenza influenza NN cord-325325-xw7627x9 141 6 vaccine vaccine NN cord-325325-xw7627x9 141 7 will will MD cord-325325-xw7627x9 141 8 not not RB cord-325325-xw7627x9 141 9 protect protect VB cord-325325-xw7627x9 141 10 against against IN cord-325325-xw7627x9 141 11 avian avian JJ cord-325325-xw7627x9 141 12 influenza influenza NN cord-325325-xw7627x9 141 13 strains strain NNS cord-325325-xw7627x9 141 14 , , , cord-325325-xw7627x9 141 15 it -PRON- PRP cord-325325-xw7627x9 141 16 should should MD cord-325325-xw7627x9 141 17 be be VB cord-325325-xw7627x9 141 18 considered consider VBN cord-325325-xw7627x9 141 19 in in IN cord-325325-xw7627x9 141 20 poultry poultry NN cord-325325-xw7627x9 141 21 workers worker NNS cord-325325-xw7627x9 141 22 , , , cord-325325-xw7627x9 141 23 and and CC cord-325325-xw7627x9 141 24 also also RB cord-325325-xw7627x9 141 25 be be VB cord-325325-xw7627x9 141 26 given give VBN cord-325325-xw7627x9 141 27 to to IN cord-325325-xw7627x9 141 28 those those DT cord-325325-xw7627x9 141 29 traveling travel VBG cord-325325-xw7627x9 141 30 to to IN cord-325325-xw7627x9 141 31 affected affected JJ cord-325325-xw7627x9 141 32 areas area NNS cord-325325-xw7627x9 141 33 , , , cord-325325-xw7627x9 141 34 two two CD cord-325325-xw7627x9 141 35 weeks week NNS cord-325325-xw7627x9 141 36 ahead ahead RB cord-325325-xw7627x9 141 37 of of IN cord-325325-xw7627x9 141 38 departure departure NN cord-325325-xw7627x9 141 39 , , , cord-325325-xw7627x9 141 40 to to TO cord-325325-xw7627x9 141 41 prevent prevent VB cord-325325-xw7627x9 141 42 co co NN cord-325325-xw7627x9 141 43 - - NN cord-325325-xw7627x9 141 44 infection infection NN cord-325325-xw7627x9 141 45 and and CC cord-325325-xw7627x9 141 46 reassortment reassortment NN cord-325325-xw7627x9 141 47 . . . cord-325325-xw7627x9 142 1 23 23 CD cord-325325-xw7627x9 143 1 According accord VBG cord-325325-xw7627x9 143 2 to to IN cord-325325-xw7627x9 143 3 Centers Centers NNPS cord-325325-xw7627x9 143 4 for for IN cord-325325-xw7627x9 143 5 Disease Disease NNP cord-325325-xw7627x9 143 6 Control Control NNP cord-325325-xw7627x9 143 7 and and CC cord-325325-xw7627x9 143 8 Prevention Prevention NNP cord-325325-xw7627x9 143 9 ( ( -LRB- cord-325325-xw7627x9 143 10 CDC CDC NNP cord-325325-xw7627x9 143 11 ) ) -RRB- cord-325325-xw7627x9 143 12 and and CC cord-325325-xw7627x9 143 13 WHO who WP cord-325325-xw7627x9 143 14 recommendations recommendation NNS cord-325325-xw7627x9 143 15 , , , cord-325325-xw7627x9 143 16 people people NNS cord-325325-xw7627x9 143 17 who who WP cord-325325-xw7627x9 143 18 live live VBP cord-325325-xw7627x9 143 19 in in IN cord-325325-xw7627x9 143 20 affected affect VBN cord-325325-xw7627x9 143 21 areas area NNS cord-325325-xw7627x9 143 22 should should MD cord-325325-xw7627x9 143 23 avoid avoid VB cord-325325-xw7627x9 143 24 all all DT cord-325325-xw7627x9 143 25 direct direct JJ cord-325325-xw7627x9 143 26 contact contact NN cord-325325-xw7627x9 143 27 with with IN cord-325325-xw7627x9 143 28 poultry poultry NN cord-325325-xw7627x9 143 29 and and CC cord-325325-xw7627x9 143 30 surfaces surface NNS cord-325325-xw7627x9 143 31 contaminated contaminate VBN cord-325325-xw7627x9 143 32 with with IN cord-325325-xw7627x9 143 33 poultry poultry NN cord-325325-xw7627x9 143 34 feces fece NNS cord-325325-xw7627x9 143 35 and and CC cord-325325-xw7627x9 143 36 secretions secretion NNS cord-325325-xw7627x9 143 37 , , , cord-325325-xw7627x9 143 38 should should MD cord-325325-xw7627x9 143 39 avoid avoid VB cord-325325-xw7627x9 143 40 eating eat VBG cord-325325-xw7627x9 143 41 undercooked undercooked JJ cord-325325-xw7627x9 143 42 eggs egg NNS cord-325325-xw7627x9 143 43 and and CC cord-325325-xw7627x9 143 44 poultry poultry NN cord-325325-xw7627x9 143 45 , , , cord-325325-xw7627x9 143 46 should should MD cord-325325-xw7627x9 143 47 wash wash VB cord-325325-xw7627x9 143 48 hands hand NNS cord-325325-xw7627x9 143 49 carefully carefully RB cord-325325-xw7627x9 143 50 and and CC cord-325325-xw7627x9 143 51 frequently frequently RB cord-325325-xw7627x9 143 52 , , , cord-325325-xw7627x9 143 53 and and CC cord-325325-xw7627x9 143 54 should should MD cord-325325-xw7627x9 143 55 seek seek VB cord-325325-xw7627x9 143 56 medical medical JJ cord-325325-xw7627x9 143 57 attention attention NN cord-325325-xw7627x9 143 58 if if IN cord-325325-xw7627x9 143 59 they -PRON- PRP cord-325325-xw7627x9 143 60 become become VBP cord-325325-xw7627x9 143 61 ill ill JJ cord-325325-xw7627x9 143 62 within within IN cord-325325-xw7627x9 143 63 10 10 CD cord-325325-xw7627x9 143 64 days day NNS cord-325325-xw7627x9 143 65 of of IN cord-325325-xw7627x9 143 66 suspected suspect VBN cord-325325-xw7627x9 143 67 contact contact NN cord-325325-xw7627x9 143 68 . . . cord-325325-xw7627x9 144 1 15 15 CD cord-325325-xw7627x9 144 2 , , , cord-325325-xw7627x9 144 3 20 20 CD cord-325325-xw7627x9 144 4 Post post JJ cord-325325-xw7627x9 144 5 - - JJ cord-325325-xw7627x9 144 6 exposure exposure JJ cord-325325-xw7627x9 144 7 prophylaxis prophylaxis NN cord-325325-xw7627x9 144 8 with with IN cord-325325-xw7627x9 144 9 oseltamivir oseltamivir NNP cord-325325-xw7627x9 144 10 75 75 CD cord-325325-xw7627x9 144 11 mg mg NNP cord-325325-xw7627x9 144 12 daily daily RB cord-325325-xw7627x9 144 13 for for IN cord-325325-xw7627x9 144 14 7 7 CD cord-325325-xw7627x9 144 15 to to TO cord-325325-xw7627x9 144 16 10 10 CD cord-325325-xw7627x9 144 17 days day NNS cord-325325-xw7627x9 144 18 should should MD cord-325325-xw7627x9 144 19 be be VB cord-325325-xw7627x9 144 20 recommended recommend VBN cord-325325-xw7627x9 144 21 to to IN cord-325325-xw7627x9 144 22 household household NN cord-325325-xw7627x9 144 23 contacts contact NNS cord-325325-xw7627x9 144 24 of of IN cord-325325-xw7627x9 144 25 patients patient NNS cord-325325-xw7627x9 144 26 . . . cord-325325-xw7627x9 145 1 23 23 CD cord-325325-xw7627x9 145 2 , , , cord-325325-xw7627x9 145 3 49 49 CD cord-325325-xw7627x9 145 4 , , , cord-325325-xw7627x9 145 5 50 50 CD cord-325325-xw7627x9 146 1 Although although IN cord-325325-xw7627x9 146 2 the the DT cord-325325-xw7627x9 146 3 risk risk NN cord-325325-xw7627x9 146 4 of of IN cord-325325-xw7627x9 146 5 transmission transmission NN cord-325325-xw7627x9 146 6 from from IN cord-325325-xw7627x9 146 7 person person NN cord-325325-xw7627x9 146 8 Influenza Influenza NNP cord-325325-xw7627x9 146 9 viruses virus NNS cord-325325-xw7627x9 146 10 and and CC cord-325325-xw7627x9 146 11 the the DT cord-325325-xw7627x9 146 12 evolution evolution NN cord-325325-xw7627x9 146 13 of of IN cord-325325-xw7627x9 146 14 avian avian JJ cord-325325-xw7627x9 146 15 influenza influenza NN cord-325325-xw7627x9 146 16 virus virus NN cord-325325-xw7627x9 146 17 H5N1 H5N1 NNP cord-325325-xw7627x9 146 18 to to IN cord-325325-xw7627x9 146 19 person person NN cord-325325-xw7627x9 146 20 appears appear VBZ cord-325325-xw7627x9 146 21 low low JJ cord-325325-xw7627x9 146 22 , , , cord-325325-xw7627x9 146 23 quarantining quarantine VBG cord-325325-xw7627x9 146 24 of of IN cord-325325-xw7627x9 146 25 close close JJ cord-325325-xw7627x9 146 26 contacts contact NNS cord-325325-xw7627x9 146 27 to to IN cord-325325-xw7627x9 146 28 patients patient NNS cord-325325-xw7627x9 146 29 for for IN cord-325325-xw7627x9 146 30 a a DT cord-325325-xw7627x9 146 31 week week NN cord-325325-xw7627x9 146 32 after after IN cord-325325-xw7627x9 146 33 last last JJ cord-325325-xw7627x9 146 34 exposure exposure NN cord-325325-xw7627x9 146 35 and and CC cord-325325-xw7627x9 146 36 monitoring monitoring NN cord-325325-xw7627x9 146 37 for for IN cord-325325-xw7627x9 146 38 symptoms symptom NNS cord-325325-xw7627x9 146 39 may may MD cord-325325-xw7627x9 146 40 help help VB cord-325325-xw7627x9 146 41 to to TO cord-325325-xw7627x9 146 42 reduce reduce VB cord-325325-xw7627x9 146 43 transmission transmission NN cord-325325-xw7627x9 146 44 rates rate NNS cord-325325-xw7627x9 146 45 . . . cord-325325-xw7627x9 147 1 23 23 CD cord-325325-xw7627x9 148 1 If if IN cord-325325-xw7627x9 148 2 available available JJ cord-325325-xw7627x9 148 3 , , , cord-325325-xw7627x9 148 4 negative negative JJ cord-325325-xw7627x9 148 5 pressure pressure NN cord-325325-xw7627x9 148 6 rooms room NNS cord-325325-xw7627x9 148 7 should should MD cord-325325-xw7627x9 148 8 be be VB cord-325325-xw7627x9 148 9 used use VBN cord-325325-xw7627x9 148 10 for for IN cord-325325-xw7627x9 148 11 patient patient JJ cord-325325-xw7627x9 148 12 isolation isolation NN cord-325325-xw7627x9 148 13 . . . cord-325325-xw7627x9 149 1 Healthcare healthcare NN cord-325325-xw7627x9 149 2 workers worker NNS cord-325325-xw7627x9 149 3 should should MD cord-325325-xw7627x9 149 4 wear wear VB cord-325325-xw7627x9 149 5 N-95 N-95 NNP cord-325325-xw7627x9 149 6 masks mask NNS cord-325325-xw7627x9 149 7 ( ( -LRB- cord-325325-xw7627x9 149 8 non non JJ cord-325325-xw7627x9 149 9 - - JJ cord-325325-xw7627x9 149 10 oilproof oilproof JJ cord-325325-xw7627x9 149 11 respirators respirator NNS cord-325325-xw7627x9 149 12 with with IN cord-325325-xw7627x9 149 13 at at RB cord-325325-xw7627x9 149 14 least least RBS cord-325325-xw7627x9 149 15 95 95 CD cord-325325-xw7627x9 149 16 % % NN cord-325325-xw7627x9 149 17 efficiency efficiency NN cord-325325-xw7627x9 149 18 in in IN cord-325325-xw7627x9 149 19 filtering filter VBG cord-325325-xw7627x9 149 20 particles particle NNS cord-325325-xw7627x9 149 21 more more JJR cord-325325-xw7627x9 149 22 than than IN cord-325325-xw7627x9 149 23 3 3 CD cord-325325-xw7627x9 149 24 mm mm NN cord-325325-xw7627x9 149 25 in in IN cord-325325-xw7627x9 149 26 diameter diameter NN cord-325325-xw7627x9 149 27 ) ) -RRB- cord-325325-xw7627x9 149 28 , , , cord-325325-xw7627x9 149 29 gloves glove NNS cord-325325-xw7627x9 149 30 , , , cord-325325-xw7627x9 149 31 long long RB cord-325325-xw7627x9 149 32 sleeved sleeve VBN cord-325325-xw7627x9 149 33 cuffed cuff VBN cord-325325-xw7627x9 149 34 gowns gown NNS cord-325325-xw7627x9 149 35 , , , cord-325325-xw7627x9 149 36 and and CC cord-325325-xw7627x9 149 37 eye eye NN cord-325325-xw7627x9 149 38 protection protection NN cord-325325-xw7627x9 149 39 when when WRB cord-325325-xw7627x9 149 40 within within IN cord-325325-xw7627x9 149 41 3 3 CD cord-325325-xw7627x9 149 42 feet foot NNS cord-325325-xw7627x9 149 43 of of IN cord-325325-xw7627x9 149 44 patients patient NNS cord-325325-xw7627x9 149 45 . . . cord-325325-xw7627x9 150 1 51 51 CD cord-325325-xw7627x9 150 2 Quarantine quarantine NN cord-325325-xw7627x9 150 3 and and CC cord-325325-xw7627x9 150 4 depopulation depopulation NN cord-325325-xw7627x9 150 5 or or CC cord-325325-xw7627x9 150 6 culling culling NN cord-325325-xw7627x9 150 7 of of IN cord-325325-xw7627x9 150 8 affected affect VBN cord-325325-xw7627x9 150 9 poultry poultry NN cord-325325-xw7627x9 150 10 is be VBZ cord-325325-xw7627x9 150 11 the the DT cord-325325-xw7627x9 150 12 preferred preferred JJ cord-325325-xw7627x9 150 13 way way NN cord-325325-xw7627x9 150 14 of of IN cord-325325-xw7627x9 150 15 eradication eradication NN cord-325325-xw7627x9 150 16 . . . cord-325325-xw7627x9 151 1 The the DT cord-325325-xw7627x9 151 2 use use NN cord-325325-xw7627x9 151 3 of of IN cord-325325-xw7627x9 151 4 inactivated inactivate VBN cord-325325-xw7627x9 151 5 H5N1 H5N1 NNP cord-325325-xw7627x9 151 6 vaccines vaccine NNS cord-325325-xw7627x9 151 7 in in IN cord-325325-xw7627x9 151 8 chickens chicken NNS cord-325325-xw7627x9 151 9 is be VBZ cord-325325-xw7627x9 151 10 an an DT cord-325325-xw7627x9 151 11 additional additional JJ cord-325325-xw7627x9 151 12 step step NN cord-325325-xw7627x9 151 13 but but CC cord-325325-xw7627x9 151 14 should should MD cord-325325-xw7627x9 151 15 be be VB cord-325325-xw7627x9 151 16 done do VBN cord-325325-xw7627x9 151 17 with with IN cord-325325-xw7627x9 151 18 caution caution NN cord-325325-xw7627x9 151 19 . . . cord-325325-xw7627x9 152 1 52 52 CD cord-325325-xw7627x9 152 2 Vaccine vaccine NN cord-325325-xw7627x9 152 3 Currently currently RB cord-325325-xw7627x9 152 4 , , , cord-325325-xw7627x9 152 5 there there EX cord-325325-xw7627x9 152 6 is be VBZ cord-325325-xw7627x9 152 7 no no DT cord-325325-xw7627x9 152 8 commercially commercially RB cord-325325-xw7627x9 152 9 available available JJ cord-325325-xw7627x9 152 10 vaccine vaccine NN cord-325325-xw7627x9 152 11 against against IN cord-325325-xw7627x9 152 12 H5N1 H5N1 NNP cord-325325-xw7627x9 152 13 virus virus NN cord-325325-xw7627x9 152 14 . . . cord-325325-xw7627x9 153 1 Due due IN cord-325325-xw7627x9 153 2 to to IN cord-325325-xw7627x9 153 3 safety safety NN cord-325325-xw7627x9 153 4 and and CC cord-325325-xw7627x9 153 5 technical technical JJ cord-325325-xw7627x9 153 6 reasons reason NNS cord-325325-xw7627x9 153 7 , , , cord-325325-xw7627x9 153 8 and and CC cord-325325-xw7627x9 153 9 since since IN cord-325325-xw7627x9 153 10 H5N1 H5N1 NNP cord-325325-xw7627x9 153 11 is be VBZ cord-325325-xw7627x9 153 12 highly highly RB cord-325325-xw7627x9 153 13 virulent virulent JJ cord-325325-xw7627x9 153 14 and and CC cord-325325-xw7627x9 153 15 lethal lethal JJ cord-325325-xw7627x9 153 16 to to IN cord-325325-xw7627x9 153 17 eggs egg NNS cord-325325-xw7627x9 153 18 , , , cord-325325-xw7627x9 153 19 traditional traditional JJ cord-325325-xw7627x9 153 20 methods method NNS cord-325325-xw7627x9 153 21 of of IN cord-325325-xw7627x9 153 22 production production NN cord-325325-xw7627x9 153 23 are be VBP cord-325325-xw7627x9 153 24 not not RB cord-325325-xw7627x9 153 25 feasible feasible JJ cord-325325-xw7627x9 153 26 . . . cord-325325-xw7627x9 154 1 Furthermore furthermore RB cord-325325-xw7627x9 154 2 , , , cord-325325-xw7627x9 154 3 it -PRON- PRP cord-325325-xw7627x9 154 4 is be VBZ cord-325325-xw7627x9 154 5 impossible impossible JJ cord-325325-xw7627x9 154 6 to to TO cord-325325-xw7627x9 154 7 predict predict VB cord-325325-xw7627x9 154 8 whether whether IN cord-325325-xw7627x9 154 9 the the DT cord-325325-xw7627x9 154 10 currently currently RB cord-325325-xw7627x9 154 11 circulating circulate VBG cord-325325-xw7627x9 154 12 H5N1 H5N1 NNP cord-325325-xw7627x9 154 13 strain strain NN cord-325325-xw7627x9 154 14 will will MD cord-325325-xw7627x9 154 15 cause cause VB cord-325325-xw7627x9 154 16 the the DT cord-325325-xw7627x9 154 17 next next JJ cord-325325-xw7627x9 154 18 pandemic pandemic NN cord-325325-xw7627x9 154 19 . . . cord-325325-xw7627x9 155 1 If if IN cord-325325-xw7627x9 155 2 successfully successfully RB cord-325325-xw7627x9 155 3 produced produce VBN cord-325325-xw7627x9 155 4 , , , cord-325325-xw7627x9 155 5 vaccines vaccine NNS cord-325325-xw7627x9 155 6 would would MD cord-325325-xw7627x9 155 7 likely likely RB cord-325325-xw7627x9 155 8 be be VB cord-325325-xw7627x9 155 9 the the DT cord-325325-xw7627x9 155 10 most most RBS cord-325325-xw7627x9 155 11 important important JJ cord-325325-xw7627x9 155 12 health health NN cord-325325-xw7627x9 155 13 tools tool NNS cord-325325-xw7627x9 155 14 to to TO cord-325325-xw7627x9 155 15 decrease decrease VB cord-325325-xw7627x9 155 16 morbidity morbidity NN cord-325325-xw7627x9 155 17 , , , cord-325325-xw7627x9 155 18 mortality mortality NN cord-325325-xw7627x9 155 19 , , , cord-325325-xw7627x9 155 20 and and CC cord-325325-xw7627x9 155 21 the the DT cord-325325-xw7627x9 155 22 economic economic JJ cord-325325-xw7627x9 155 23 effects effect NNS cord-325325-xw7627x9 155 24 of of IN cord-325325-xw7627x9 155 25 pandemic pandemic NN cord-325325-xw7627x9 155 26 influenza influenza NN cord-325325-xw7627x9 155 27 . . . cord-325325-xw7627x9 156 1 Resistance resistance NN cord-325325-xw7627x9 156 2 to to IN cord-325325-xw7627x9 156 3 oseltamivir oseltamivir NNP cord-325325-xw7627x9 156 4 makes make VBZ cord-325325-xw7627x9 156 5 vaccines vaccine NNS cord-325325-xw7627x9 156 6 even even RB cord-325325-xw7627x9 156 7 more more RBR cord-325325-xw7627x9 156 8 important important JJ cord-325325-xw7627x9 156 9 . . . cord-325325-xw7627x9 157 1 23 23 CD cord-325325-xw7627x9 157 2 , , , cord-325325-xw7627x9 157 3 53 53 CD cord-325325-xw7627x9 157 4 The the DT cord-325325-xw7627x9 157 5 H5N1 H5N1 NNP cord-325325-xw7627x9 157 6 viruses virus NNS cord-325325-xw7627x9 157 7 can can MD cord-325325-xw7627x9 157 8 be be VB cord-325325-xw7627x9 157 9 divided divide VBN cord-325325-xw7627x9 157 10 into into IN cord-325325-xw7627x9 157 11 clade clade NN cord-325325-xw7627x9 157 12 1 1 CD cord-325325-xw7627x9 157 13 and and CC cord-325325-xw7627x9 157 14 clade clade NN cord-325325-xw7627x9 157 15 2 2 CD cord-325325-xw7627x9 157 16 ; ; : cord-325325-xw7627x9 157 17 the the DT cord-325325-xw7627x9 157 18 latter latter JJ cord-325325-xw7627x9 157 19 can can MD cord-325325-xw7627x9 157 20 be be VB cord-325325-xw7627x9 157 21 further further RB cord-325325-xw7627x9 157 22 subdivided subdivide VBN cord-325325-xw7627x9 157 23 into into IN cord-325325-xw7627x9 157 24 three three CD cord-325325-xw7627x9 157 25 subclades subclade NNS cord-325325-xw7627x9 157 26 . . . cord-325325-xw7627x9 158 1 These these DT cord-325325-xw7627x9 158 2 clades clade NNS cord-325325-xw7627x9 158 3 and and CC cord-325325-xw7627x9 158 4 subclades subclade NNS cord-325325-xw7627x9 158 5 probably probably RB cord-325325-xw7627x9 158 6 differ differ VBP cord-325325-xw7627x9 158 7 sufficiently sufficiently RB cord-325325-xw7627x9 158 8 in in IN cord-325325-xw7627x9 158 9 their -PRON- PRP$ cord-325325-xw7627x9 158 10 antigenic antigenic JJ cord-325325-xw7627x9 158 11 structure structure NN cord-325325-xw7627x9 158 12 to to TO cord-325325-xw7627x9 158 13 warrant warrant VB cord-325325-xw7627x9 158 14 the the DT cord-325325-xw7627x9 158 15 preparation preparation NN cord-325325-xw7627x9 158 16 of of IN cord-325325-xw7627x9 158 17 different different JJ cord-325325-xw7627x9 158 18 vaccines vaccine NNS cord-325325-xw7627x9 158 19 . . . cord-325325-xw7627x9 159 1 Studies study NNS cord-325325-xw7627x9 159 2 in in IN cord-325325-xw7627x9 159 3 ferrets ferret NNS cord-325325-xw7627x9 159 4 suggest suggest VBP cord-325325-xw7627x9 159 5 that that DT cord-325325-xw7627x9 159 6 vaccination vaccination NN cord-325325-xw7627x9 159 7 against against IN cord-325325-xw7627x9 159 8 one one CD cord-325325-xw7627x9 159 9 clade clade NN cord-325325-xw7627x9 159 10 will will MD cord-325325-xw7627x9 159 11 not not RB cord-325325-xw7627x9 159 12 protect protect VB cord-325325-xw7627x9 159 13 against against IN cord-325325-xw7627x9 159 14 infection infection NN cord-325325-xw7627x9 159 15 with with IN cord-325325-xw7627x9 159 16 another another DT cord-325325-xw7627x9 159 17 clade clade NN cord-325325-xw7627x9 159 18 , , , cord-325325-xw7627x9 159 19 though though IN cord-325325-xw7627x9 159 20 it -PRON- PRP cord-325325-xw7627x9 159 21 will will MD cord-325325-xw7627x9 159 22 protect protect VB cord-325325-xw7627x9 159 23 against against IN cord-325325-xw7627x9 159 24 influenza influenza NN cord-325325-xw7627x9 159 25 - - HYPH cord-325325-xw7627x9 159 26 associated associate VBN cord-325325-xw7627x9 159 27 death death NN cord-325325-xw7627x9 159 28 . . . cord-325325-xw7627x9 160 1 54 54 CD cord-325325-xw7627x9 161 1 A a DT cord-325325-xw7627x9 161 2 new new JJ cord-325325-xw7627x9 161 3 vaccine vaccine NN cord-325325-xw7627x9 161 4 prepared prepare VBN cord-325325-xw7627x9 161 5 from from IN cord-325325-xw7627x9 161 6 an an DT cord-325325-xw7627x9 161 7 egg egg NN cord-325325-xw7627x9 161 8 - - HYPH cord-325325-xw7627x9 161 9 grown grow VBN cord-325325-xw7627x9 161 10 recombinant recombinant JJ cord-325325-xw7627x9 161 11 influenza influenza NN cord-325325-xw7627x9 161 12 A a DT cord-325325-xw7627x9 161 13 virus virus NN cord-325325-xw7627x9 161 14 , , , cord-325325-xw7627x9 161 15 composed compose VBN cord-325325-xw7627x9 161 16 of of IN cord-325325-xw7627x9 161 17 the the DT cord-325325-xw7627x9 161 18 hemagglutinin hemagglutinin NN cord-325325-xw7627x9 161 19 and and CC cord-325325-xw7627x9 161 20 neuraminidase neuraminidase NN cord-325325-xw7627x9 161 21 genes gene NNS cord-325325-xw7627x9 161 22 from from IN cord-325325-xw7627x9 161 23 a a DT cord-325325-xw7627x9 161 24 human human JJ cord-325325-xw7627x9 161 25 H5N1 H5N1 NNP cord-325325-xw7627x9 161 26 isolate isolate VB cord-325325-xw7627x9 161 27 inserted insert VBN cord-325325-xw7627x9 161 28 into into IN cord-325325-xw7627x9 161 29 a a DT cord-325325-xw7627x9 161 30 laboratory laboratory NN cord-325325-xw7627x9 161 31 - - HYPH cord-325325-xw7627x9 161 32 adapted adapt VBN cord-325325-xw7627x9 161 33 human human JJ cord-325325-xw7627x9 161 34 influenza influenza NN cord-325325-xw7627x9 161 35 A a DT cord-325325-xw7627x9 161 36 strain strain NN cord-325325-xw7627x9 161 37 , , , cord-325325-xw7627x9 161 38 achieved achieve VBN cord-325325-xw7627x9 161 39 only only RB cord-325325-xw7627x9 161 40 54 54 CD cord-325325-xw7627x9 161 41 % % NN cord-325325-xw7627x9 161 42 presumably presumably RB cord-325325-xw7627x9 161 43 protective protective JJ cord-325325-xw7627x9 161 44 micro micro NN cord-325325-xw7627x9 161 45 - - HYPH cord-325325-xw7627x9 161 46 neutralization neutralization NN cord-325325-xw7627x9 161 47 titers titer NNS cord-325325-xw7627x9 161 48 of of IN cord-325325-xw7627x9 161 49 1:40 1:40 CD cord-325325-xw7627x9 161 50 following follow VBG cord-325325-xw7627x9 161 51 use use NN cord-325325-xw7627x9 161 52 of of IN cord-325325-xw7627x9 161 53 the the DT cord-325325-xw7627x9 161 54 maximum maximum JJ cord-325325-xw7627x9 161 55 tested test VBN cord-325325-xw7627x9 161 56 dose dose NN cord-325325-xw7627x9 161 57 ( ( -LRB- cord-325325-xw7627x9 161 58 90 90 CD cord-325325-xw7627x9 161 59 mg mg NN cord-325325-xw7627x9 161 60 ) ) -RRB- cord-325325-xw7627x9 161 61 . . . cord-325325-xw7627x9 162 1 This this DT cord-325325-xw7627x9 162 2 dose dose NN cord-325325-xw7627x9 162 3 is be VBZ cord-325325-xw7627x9 162 4 12 12 CD cord-325325-xw7627x9 162 5 times time NNS cord-325325-xw7627x9 162 6 that that DT cord-325325-xw7627x9 162 7 of of IN cord-325325-xw7627x9 162 8 the the DT cord-325325-xw7627x9 162 9 seasonal seasonal JJ cord-325325-xw7627x9 162 10 influenza influenza NN cord-325325-xw7627x9 162 11 vaccine vaccine NN cord-325325-xw7627x9 162 12 , , , cord-325325-xw7627x9 162 13 making make VBG cord-325325-xw7627x9 162 14 mass mass NN cord-325325-xw7627x9 162 15 production production NN cord-325325-xw7627x9 162 16 untenable untenable JJ cord-325325-xw7627x9 162 17 with with IN cord-325325-xw7627x9 162 18 current current JJ cord-325325-xw7627x9 162 19 manufacturing manufacturing NN cord-325325-xw7627x9 162 20 capacity capacity NN cord-325325-xw7627x9 162 21 . . . cord-325325-xw7627x9 163 1 Current current JJ cord-325325-xw7627x9 163 2 seasonal seasonal JJ cord-325325-xw7627x9 163 3 vaccines vaccine NNS cord-325325-xw7627x9 163 4 contain contain VBP cord-325325-xw7627x9 163 5 15 15 CD cord-325325-xw7627x9 163 6 mg mg NNP cord-325325-xw7627x9 163 7 HA/ ha/ CD cord-325325-xw7627x9 163 8 strain strain NN cord-325325-xw7627x9 163 9 / / SYM cord-325325-xw7627x9 163 10 dose dose NN cord-325325-xw7627x9 163 11 . . . cord-325325-xw7627x9 164 1 Whether whether IN cord-325325-xw7627x9 164 2 this this DT cord-325325-xw7627x9 164 3 vaccine vaccine NN cord-325325-xw7627x9 164 4 could could MD cord-325325-xw7627x9 164 5 induce induce VB cord-325325-xw7627x9 164 6 cross cross NN cord-325325-xw7627x9 164 7 - - NN cord-325325-xw7627x9 164 8 protection protection NN cord-325325-xw7627x9 164 9 against against IN cord-325325-xw7627x9 164 10 other other JJ cord-325325-xw7627x9 164 11 H5N1 H5N1 NNP cord-325325-xw7627x9 164 12 strains strain NNS cord-325325-xw7627x9 164 13 is be VBZ cord-325325-xw7627x9 164 14 unclear unclear JJ cord-325325-xw7627x9 164 15 . . . cord-325325-xw7627x9 165 1 Furthermore furthermore RB cord-325325-xw7627x9 165 2 , , , cord-325325-xw7627x9 165 3 the the DT cord-325325-xw7627x9 165 4 death death NN cord-325325-xw7627x9 165 5 of of IN cord-325325-xw7627x9 165 6 a a DT cord-325325-xw7627x9 165 7 Chinese chinese JJ cord-325325-xw7627x9 165 8 woman woman NN cord-325325-xw7627x9 165 9 infected infect VBN cord-325325-xw7627x9 165 10 with with IN cord-325325-xw7627x9 165 11 an an DT cord-325325-xw7627x9 165 12 H5N1 H5N1 NNP cord-325325-xw7627x9 165 13 strain strain NN cord-325325-xw7627x9 165 14 markedly markedly RB cord-325325-xw7627x9 165 15 different different JJ cord-325325-xw7627x9 165 16 from from IN cord-325325-xw7627x9 165 17 those those DT cord-325325-xw7627x9 165 18 now now RB cord-325325-xw7627x9 165 19 being be VBG cord-325325-xw7627x9 165 20 used use VBN cord-325325-xw7627x9 165 21 to to TO cord-325325-xw7627x9 165 22 develop develop VB cord-325325-xw7627x9 165 23 vaccines vaccine NNS cord-325325-xw7627x9 165 24 has have VBZ cord-325325-xw7627x9 165 25 recently recently RB cord-325325-xw7627x9 165 26 been be VBN cord-325325-xw7627x9 165 27 reported report VBN cord-325325-xw7627x9 165 28 . . . cord-325325-xw7627x9 166 1 [ [ -LRB- cord-325325-xw7627x9 166 2 55 55 CD cord-325325-xw7627x9 166 3 ] ] -RRB- cord-325325-xw7627x9 166 4 [ [ -LRB- cord-325325-xw7627x9 166 5 56 56 CD cord-325325-xw7627x9 166 6 ] ] -RRB- cord-325325-xw7627x9 166 7 [ [ -LRB- cord-325325-xw7627x9 166 8 57 57 CD cord-325325-xw7627x9 166 9 ] ] -RRB- cord-325325-xw7627x9 167 1 Studies study NNS cord-325325-xw7627x9 167 2 of of IN cord-325325-xw7627x9 167 3 different different JJ cord-325325-xw7627x9 167 4 dose dose NN cord-325325-xw7627x9 167 5 levels level NNS cord-325325-xw7627x9 167 6 of of IN cord-325325-xw7627x9 167 7 vaccines vaccine NNS cord-325325-xw7627x9 167 8 administered administer VBN cord-325325-xw7627x9 167 9 with with IN cord-325325-xw7627x9 167 10 adjuvants adjuvant NNS cord-325325-xw7627x9 167 11 like like IN cord-325325-xw7627x9 167 12 aluminum aluminum NN cord-325325-xw7627x9 167 13 hydroxide hydroxide NN cord-325325-xw7627x9 167 14 are be VBP cord-325325-xw7627x9 167 15 urgently urgently RB cord-325325-xw7627x9 167 16 needed need VBN cord-325325-xw7627x9 167 17 to to TO cord-325325-xw7627x9 167 18 improve improve VB cord-325325-xw7627x9 167 19 immunogenicity immunogenicity NN cord-325325-xw7627x9 167 20 and and CC cord-325325-xw7627x9 167 21 increase increase VB cord-325325-xw7627x9 167 22 the the DT cord-325325-xw7627x9 167 23 number number NN cord-325325-xw7627x9 167 24 of of IN cord-325325-xw7627x9 167 25 doses dose NNS cord-325325-xw7627x9 167 26 available available JJ cord-325325-xw7627x9 167 27 ( ( -LRB- cord-325325-xw7627x9 167 28 if if IN cord-325325-xw7627x9 167 29 lower low JJR cord-325325-xw7627x9 167 30 doses dose NNS cord-325325-xw7627x9 167 31 are be VBP cord-325325-xw7627x9 167 32 effective effective JJ cord-325325-xw7627x9 167 33 ) ) -RRB- cord-325325-xw7627x9 167 34 . . . cord-325325-xw7627x9 168 1 [ [ -LRB- cord-325325-xw7627x9 168 2 57 57 CD cord-325325-xw7627x9 168 3 ] ] -RRB- cord-325325-xw7627x9 168 4 [ [ -LRB- cord-325325-xw7627x9 168 5 58 58 CD cord-325325-xw7627x9 168 6 ] ] -RRB- cord-325325-xw7627x9 169 1 [ [ -LRB- cord-325325-xw7627x9 169 2 59 59 CD cord-325325-xw7627x9 169 3 ] ] -RRB- cord-325325-xw7627x9 170 1 Recently recently RB cord-325325-xw7627x9 170 2 , , , cord-325325-xw7627x9 170 3 promising promising JJ cord-325325-xw7627x9 170 4 progress progress NN cord-325325-xw7627x9 170 5 has have VBZ cord-325325-xw7627x9 170 6 been be VBN cord-325325-xw7627x9 170 7 made make VBN cord-325325-xw7627x9 170 8 in in IN cord-325325-xw7627x9 170 9 industry industry NN cord-325325-xw7627x9 170 10 - - HYPH cord-325325-xw7627x9 170 11 supported support VBN cord-325325-xw7627x9 170 12 research research NN cord-325325-xw7627x9 170 13 in in IN cord-325325-xw7627x9 170 14 France France NNP cord-325325-xw7627x9 170 15 and and CC cord-325325-xw7627x9 170 16 the the DT cord-325325-xw7627x9 170 17 UK UK NNP cord-325325-xw7627x9 170 18 , , , cord-325325-xw7627x9 170 19 where where WRB cord-325325-xw7627x9 170 20 the the DT cord-325325-xw7627x9 170 21 safety safety NN cord-325325-xw7627x9 170 22 and and CC cord-325325-xw7627x9 170 23 immunogenicity immunogenicity NN cord-325325-xw7627x9 170 24 of of IN cord-325325-xw7627x9 170 25 a a DT cord-325325-xw7627x9 170 26 monovalent monovalent NN cord-325325-xw7627x9 170 27 , , , cord-325325-xw7627x9 170 28 inactivated inactivate VBN cord-325325-xw7627x9 170 29 split split NN cord-325325-xw7627x9 170 30 - - HYPH cord-325325-xw7627x9 170 31 virion virion NN cord-325325-xw7627x9 170 32 vaccine vaccine NN cord-325325-xw7627x9 170 33 , , , cord-325325-xw7627x9 170 34 derived derive VBN cord-325325-xw7627x9 170 35 from from IN cord-325325-xw7627x9 170 36 a a DT cord-325325-xw7627x9 170 37 highly highly RB cord-325325-xw7627x9 170 38 pathogenic pathogenic JJ cord-325325-xw7627x9 170 39 strain strain NN cord-325325-xw7627x9 170 40 of of IN cord-325325-xw7627x9 170 41 H5N1 H5N1 NNP cord-325325-xw7627x9 170 42 influenza influenza NN cord-325325-xw7627x9 170 43 , , , cord-325325-xw7627x9 170 44 has have VBZ cord-325325-xw7627x9 170 45 been be VBN cord-325325-xw7627x9 170 46 investigated investigate VBN cord-325325-xw7627x9 170 47 ; ; : cord-325325-xw7627x9 170 48 this this DT cord-325325-xw7627x9 170 49 vaccine vaccine NN cord-325325-xw7627x9 170 50 was be VBD cord-325325-xw7627x9 170 51 administered administer VBN cord-325325-xw7627x9 170 52 with with IN cord-325325-xw7627x9 170 53 and and CC cord-325325-xw7627x9 170 54 without without IN cord-325325-xw7627x9 170 55 a a DT cord-325325-xw7627x9 170 56 fixed fixed JJ cord-325325-xw7627x9 170 57 dose dose NN cord-325325-xw7627x9 170 58 of of IN cord-325325-xw7627x9 170 59 aluminum aluminum NN cord-325325-xw7627x9 170 60 hydroxide hydroxide NN cord-325325-xw7627x9 170 61 as as IN cord-325325-xw7627x9 170 62 an an DT cord-325325-xw7627x9 170 63 adjuvant adjuvant NN cord-325325-xw7627x9 170 64 . . . cord-325325-xw7627x9 171 1 On on IN cord-325325-xw7627x9 171 2 day day NN cord-325325-xw7627x9 171 3 42 42 CD cord-325325-xw7627x9 171 4 , , , cord-325325-xw7627x9 171 5 67 67 CD cord-325325-xw7627x9 171 6 % % NN cord-325325-xw7627x9 171 7 of of IN cord-325325-xw7627x9 171 8 subjects subject NNS cord-325325-xw7627x9 171 9 who who WP cord-325325-xw7627x9 171 10 received receive VBD cord-325325-xw7627x9 171 11 the the DT cord-325325-xw7627x9 171 12 highest high JJS cord-325325-xw7627x9 171 13 dose dose NN cord-325325-xw7627x9 171 14 HA HA NNP cord-325325-xw7627x9 171 15 with with IN cord-325325-xw7627x9 171 16 adjuvant adjuvant NN cord-325325-xw7627x9 171 17 exhibited exhibit VBD cord-325325-xw7627x9 171 18 detectable detectable JJ cord-325325-xw7627x9 171 19 antibody antibody NN cord-325325-xw7627x9 171 20 titers titer NNS cord-325325-xw7627x9 171 21 , , , cord-325325-xw7627x9 171 22 and and CC cord-325325-xw7627x9 171 23 61 61 CD cord-325325-xw7627x9 171 24 % % NN cord-325325-xw7627x9 171 25 had have VBD cord-325325-xw7627x9 171 26 positive positive JJ cord-325325-xw7627x9 171 27 HA HA NNP cord-325325-xw7627x9 171 28 - - HYPH cord-325325-xw7627x9 171 29 inhibition inhibition NN cord-325325-xw7627x9 171 30 responses response NNS cord-325325-xw7627x9 171 31 . . . cord-325325-xw7627x9 172 1 60 60 CD cord-325325-xw7627x9 172 2 Other other JJ cord-325325-xw7627x9 172 3 promising promising JJ cord-325325-xw7627x9 172 4 approaches approach NNS cord-325325-xw7627x9 172 5 to to IN cord-325325-xw7627x9 172 6 vaccine vaccine VB cord-325325-xw7627x9 172 7 development development NN cord-325325-xw7627x9 172 8 involve involve VBP cord-325325-xw7627x9 172 9 DNA dna NN cord-325325-xw7627x9 172 10 , , , cord-325325-xw7627x9 172 11 adenovirus adenovirus NN cord-325325-xw7627x9 172 12 vectors vector NNS cord-325325-xw7627x9 172 13 , , , cord-325325-xw7627x9 172 14 and and CC cord-325325-xw7627x9 172 15 cell cell NN cord-325325-xw7627x9 172 16 manufacturing manufacturing NN cord-325325-xw7627x9 172 17 techniques technique NNS cord-325325-xw7627x9 172 18 to to TO cord-325325-xw7627x9 172 19 increase increase VB cord-325325-xw7627x9 172 20 the the DT cord-325325-xw7627x9 172 21 speed speed NN cord-325325-xw7627x9 172 22 and and CC cord-325325-xw7627x9 172 23 capacity capacity NN cord-325325-xw7627x9 172 24 of of IN cord-325325-xw7627x9 172 25 vaccine vaccine NN cord-325325-xw7627x9 172 26 production production NN cord-325325-xw7627x9 172 27 . . . cord-325325-xw7627x9 173 1 61 61 CD cord-325325-xw7627x9 173 2 , , , cord-325325-xw7627x9 173 3 62 62 CD cord-325325-xw7627x9 173 4 On on IN cord-325325-xw7627x9 173 5 April April NNP cord-325325-xw7627x9 173 6 17 17 CD cord-325325-xw7627x9 173 7 , , , cord-325325-xw7627x9 173 8 2007 2007 CD cord-325325-xw7627x9 173 9 , , , cord-325325-xw7627x9 173 10 the the DT cord-325325-xw7627x9 173 11 U.S. U.S. NNP cord-325325-xw7627x9 173 12 Food Food NNP cord-325325-xw7627x9 173 13 and and CC cord-325325-xw7627x9 173 14 Drug Drug NNP cord-325325-xw7627x9 173 15 Administration Administration NNP cord-325325-xw7627x9 173 16 ( ( -LRB- cord-325325-xw7627x9 173 17 FDA FDA NNP cord-325325-xw7627x9 173 18 ) ) -RRB- cord-325325-xw7627x9 173 19 approved approve VBD cord-325325-xw7627x9 173 20 a a DT cord-325325-xw7627x9 173 21 human human JJ cord-325325-xw7627x9 173 22 vaccine vaccine NN cord-325325-xw7627x9 173 23 against against IN cord-325325-xw7627x9 173 24 the the DT cord-325325-xw7627x9 173 25 H5N1 H5N1 NNP cord-325325-xw7627x9 173 26 influenza influenza NN cord-325325-xw7627x9 173 27 virus virus NN cord-325325-xw7627x9 173 28 , , , cord-325325-xw7627x9 173 29 marking mark VBG cord-325325-xw7627x9 173 30 the the DT cord-325325-xw7627x9 173 31 first first JJ cord-325325-xw7627x9 173 32 such such JJ cord-325325-xw7627x9 173 33 approval approval NN cord-325325-xw7627x9 173 34 in in IN cord-325325-xw7627x9 173 35 the the DT cord-325325-xw7627x9 173 36 USA USA NNP cord-325325-xw7627x9 173 37 . . . cord-325325-xw7627x9 174 1 Should Should MD cord-325325-xw7627x9 174 2 H5N1 H5N1 NNP cord-325325-xw7627x9 174 3 develop develop VB cord-325325-xw7627x9 174 4 the the DT cord-325325-xw7627x9 174 5 ability ability NN cord-325325-xw7627x9 174 6 to to TO cord-325325-xw7627x9 174 7 spread spread VB cord-325325-xw7627x9 174 8 readily readily RB cord-325325-xw7627x9 174 9 from from IN cord-325325-xw7627x9 174 10 person person NN cord-325325-xw7627x9 174 11 to to IN cord-325325-xw7627x9 174 12 person person NN cord-325325-xw7627x9 174 13 , , , cord-325325-xw7627x9 174 14 this this DT cord-325325-xw7627x9 174 15 vaccine vaccine NN cord-325325-xw7627x9 174 16 may may MD cord-325325-xw7627x9 174 17 provide provide VB cord-325325-xw7627x9 174 18 early early JJ cord-325325-xw7627x9 174 19 limited limited JJ cord-325325-xw7627x9 174 20 protection protection NN cord-325325-xw7627x9 174 21 in in IN cord-325325-xw7627x9 174 22 the the DT cord-325325-xw7627x9 174 23 months month NNS cord-325325-xw7627x9 174 24 before before IN cord-325325-xw7627x9 174 25 a a DT cord-325325-xw7627x9 174 26 vaccine vaccine NN cord-325325-xw7627x9 174 27 tailored tailor VBN cord-325325-xw7627x9 174 28 to to IN cord-325325-xw7627x9 174 29 the the DT cord-325325-xw7627x9 174 30 pandemic pandemic JJ cord-325325-xw7627x9 174 31 strain strain NN cord-325325-xw7627x9 174 32 of of IN cord-325325-xw7627x9 174 33 the the DT cord-325325-xw7627x9 174 34 virus virus NN cord-325325-xw7627x9 174 35 can can MD cord-325325-xw7627x9 174 36 be be VB cord-325325-xw7627x9 174 37 developed develop VBN cord-325325-xw7627x9 174 38 and and CC cord-325325-xw7627x9 174 39 produced produce VBN cord-325325-xw7627x9 174 40 . . . cord-325325-xw7627x9 175 1 The the DT cord-325325-xw7627x9 175 2 vaccine vaccine NN cord-325325-xw7627x9 175 3 will will MD cord-325325-xw7627x9 175 4 be be VB cord-325325-xw7627x9 175 5 kept keep VBN cord-325325-xw7627x9 175 6 in in IN cord-325325-xw7627x9 175 7 a a DT cord-325325-xw7627x9 175 8 federal federal JJ cord-325325-xw7627x9 175 9 stockpile stockpile NN cord-325325-xw7627x9 175 10 and and CC cord-325325-xw7627x9 175 11 will will MD cord-325325-xw7627x9 175 12 be be VB cord-325325-xw7627x9 175 13 made make VBN cord-325325-xw7627x9 175 14 available available JJ cord-325325-xw7627x9 175 15 only only RB cord-325325-xw7627x9 175 16 through through IN cord-325325-xw7627x9 175 17 public public JJ cord-325325-xw7627x9 175 18 health health NN cord-325325-xw7627x9 175 19 officials official NNS cord-325325-xw7627x9 175 20 ; ; : cord-325325-xw7627x9 175 21 it -PRON- PRP cord-325325-xw7627x9 175 22 is be VBZ cord-325325-xw7627x9 175 23 approved approve VBN cord-325325-xw7627x9 175 24 for for IN cord-325325-xw7627x9 175 25 those those DT cord-325325-xw7627x9 175 26 aged age VBN cord-325325-xw7627x9 175 27 18 18 CD cord-325325-xw7627x9 175 28 to to TO cord-325325-xw7627x9 175 29 64 64 CD cord-325325-xw7627x9 175 30 years year NNS cord-325325-xw7627x9 175 31 who who WP cord-325325-xw7627x9 175 32 are be VBP cord-325325-xw7627x9 175 33 at at IN cord-325325-xw7627x9 175 34 increased increase VBN cord-325325-xw7627x9 175 35 risk risk NN cord-325325-xw7627x9 175 36 for for IN cord-325325-xw7627x9 175 37 H5N1 H5N1 NNP cord-325325-xw7627x9 175 38 exposure exposure NN cord-325325-xw7627x9 175 39 . . . cord-325325-xw7627x9 176 1 63 63 CD cord-325325-xw7627x9 176 2 _SP cord-325325-xw7627x9 177 1 For for IN cord-325325-xw7627x9 177 2 a a DT cord-325325-xw7627x9 177 3 pandemic pandemic NN cord-325325-xw7627x9 177 4 to to TO cord-325325-xw7627x9 177 5 occur occur VB cord-325325-xw7627x9 177 6 , , , cord-325325-xw7627x9 177 7 three three CD cord-325325-xw7627x9 177 8 conditions condition NNS cord-325325-xw7627x9 177 9 must must MD cord-325325-xw7627x9 177 10 be be VB cord-325325-xw7627x9 177 11 met meet VBN cord-325325-xw7627x9 178 1 : : : cord-325325-xw7627x9 178 2 a a DT cord-325325-xw7627x9 178 3 new new JJ cord-325325-xw7627x9 178 4 influenza influenza NN cord-325325-xw7627x9 178 5 virus virus NN cord-325325-xw7627x9 178 6 subtype subtype NN cord-325325-xw7627x9 178 7 must must MD cord-325325-xw7627x9 178 8 emerge emerge VB cord-325325-xw7627x9 178 9 , , , cord-325325-xw7627x9 178 10 this this DT cord-325325-xw7627x9 178 11 must must MD cord-325325-xw7627x9 178 12 infect infect VB cord-325325-xw7627x9 178 13 humans human NNS cord-325325-xw7627x9 178 14 and and CC cord-325325-xw7627x9 178 15 cause cause VB cord-325325-xw7627x9 178 16 serious serious JJ cord-325325-xw7627x9 178 17 disease disease NN cord-325325-xw7627x9 178 18 , , , cord-325325-xw7627x9 178 19 and and CC cord-325325-xw7627x9 178 20 finally finally RB cord-325325-xw7627x9 178 21 spread spread VB cord-325325-xw7627x9 178 22 easily easily RB cord-325325-xw7627x9 178 23 among among IN cord-325325-xw7627x9 178 24 humans human NNS cord-325325-xw7627x9 178 25 . . . cord-325325-xw7627x9 179 1 20 20 CD cord-325325-xw7627x9 180 1 The the DT cord-325325-xw7627x9 180 2 first first JJ cord-325325-xw7627x9 180 3 two two CD cord-325325-xw7627x9 180 4 conditions condition NNS cord-325325-xw7627x9 180 5 have have VBP cord-325325-xw7627x9 180 6 already already RB cord-325325-xw7627x9 180 7 been be VBN cord-325325-xw7627x9 180 8 met meet VBN cord-325325-xw7627x9 180 9 , , , cord-325325-xw7627x9 180 10 and and CC cord-325325-xw7627x9 180 11 there there EX cord-325325-xw7627x9 180 12 are be VBP cord-325325-xw7627x9 180 13 new new JJ cord-325325-xw7627x9 180 14 suggestions suggestion NNS cord-325325-xw7627x9 180 15 of of IN cord-325325-xw7627x9 180 16 human human NN cord-325325-xw7627x9 180 17 - - HYPH cord-325325-xw7627x9 180 18 to to IN cord-325325-xw7627x9 180 19 - - HYPH cord-325325-xw7627x9 180 20 human human JJ cord-325325-xw7627x9 180 21 transmission transmission NN cord-325325-xw7627x9 180 22 in in IN cord-325325-xw7627x9 180 23 Thailand Thailand NNP cord-325325-xw7627x9 180 24 and and CC cord-325325-xw7627x9 180 25 Indonesia Indonesia NNP cord-325325-xw7627x9 180 26 . . . cord-325325-xw7627x9 181 1 However however RB cord-325325-xw7627x9 181 2 , , , cord-325325-xw7627x9 181 3 there there EX cord-325325-xw7627x9 181 4 is be VBZ cord-325325-xw7627x9 181 5 no no DT cord-325325-xw7627x9 181 6 evidence evidence NN cord-325325-xw7627x9 181 7 to to IN cord-325325-xw7627x9 181 8 - - HYPH cord-325325-xw7627x9 181 9 date date NN cord-325325-xw7627x9 181 10 of of IN cord-325325-xw7627x9 181 11 the the DT cord-325325-xw7627x9 181 12 easy easy JJ cord-325325-xw7627x9 181 13 human human NN cord-325325-xw7627x9 181 14 - - HYPH cord-325325-xw7627x9 181 15 to to IN cord-325325-xw7627x9 181 16 - - HYPH cord-325325-xw7627x9 181 17 human human JJ cord-325325-xw7627x9 181 18 transmission transmission NN cord-325325-xw7627x9 181 19 that that WDT cord-325325-xw7627x9 181 20 is be VBZ cord-325325-xw7627x9 181 21 key key JJ cord-325325-xw7627x9 181 22 for for IN cord-325325-xw7627x9 181 23 a a DT cord-325325-xw7627x9 181 24 pandemic pandemic NN cord-325325-xw7627x9 181 25 . . . cord-325325-xw7627x9 182 1 [ [ -LRB- cord-325325-xw7627x9 182 2 20 20 CD cord-325325-xw7627x9 182 3 ] ] -RRB- cord-325325-xw7627x9 182 4 [ [ -LRB- cord-325325-xw7627x9 182 5 21 21 CD cord-325325-xw7627x9 182 6 ] ] -RRB- cord-325325-xw7627x9 182 7 [ [ -LRB- cord-325325-xw7627x9 182 8 22 22 CD cord-325325-xw7627x9 182 9 ] ] -RRB- cord-325325-xw7627x9 183 1 [ [ -LRB- cord-325325-xw7627x9 183 2 23 23 CD cord-325325-xw7627x9 183 3 ] ] -RRB- cord-325325-xw7627x9 184 1 With with IN cord-325325-xw7627x9 184 2 the the DT cord-325325-xw7627x9 184 3 emergence emergence NN cord-325325-xw7627x9 184 4 of of IN cord-325325-xw7627x9 184 5 influenza influenza NN cord-325325-xw7627x9 184 6 virus virus NN cord-325325-xw7627x9 184 7 H5N1 H5N1 NNP cord-325325-xw7627x9 184 8 , , , cord-325325-xw7627x9 184 9 the the DT cord-325325-xw7627x9 184 10 threat threat NN cord-325325-xw7627x9 184 11 of of IN cord-325325-xw7627x9 184 12 an an DT cord-325325-xw7627x9 184 13 influenza influenza NN cord-325325-xw7627x9 184 14 pandemic pandemic NN cord-325325-xw7627x9 184 15 seems seem VBZ cord-325325-xw7627x9 184 16 to to TO cord-325325-xw7627x9 184 17 be be VB cord-325325-xw7627x9 184 18 real real JJ cord-325325-xw7627x9 184 19 and and CC cord-325325-xw7627x9 184 20 inevitable inevitable JJ cord-325325-xw7627x9 184 21 , , , cord-325325-xw7627x9 184 22 but but CC cord-325325-xw7627x9 184 23 no no DT cord-325325-xw7627x9 184 24 one one NN cord-325325-xw7627x9 184 25 can can MD cord-325325-xw7627x9 184 26 predict predict VB cord-325325-xw7627x9 184 27 when when WRB cord-325325-xw7627x9 184 28 it -PRON- PRP cord-325325-xw7627x9 184 29 might may MD cord-325325-xw7627x9 184 30 happen happen VB cord-325325-xw7627x9 184 31 . . . cord-325325-xw7627x9 185 1 According accord VBG cord-325325-xw7627x9 185 2 to to IN cord-325325-xw7627x9 185 3 a a DT cord-325325-xw7627x9 185 4 study study NN cord-325325-xw7627x9 185 5 by by IN cord-325325-xw7627x9 185 6 the the DT cord-325325-xw7627x9 185 7 Congressional Congressional NNP cord-325325-xw7627x9 185 8 Budget Budget NNP cord-325325-xw7627x9 185 9 Office Office NNP cord-325325-xw7627x9 185 10 , , , cord-325325-xw7627x9 185 11 the the DT cord-325325-xw7627x9 185 12 consequences consequence NNS cord-325325-xw7627x9 185 13 of of IN cord-325325-xw7627x9 185 14 a a DT cord-325325-xw7627x9 185 15 severe severe JJ cord-325325-xw7627x9 185 16 pandemic pandemic NN cord-325325-xw7627x9 185 17 could could MD cord-325325-xw7627x9 185 18 , , , cord-325325-xw7627x9 185 19 in in IN cord-325325-xw7627x9 185 20 the the DT cord-325325-xw7627x9 185 21 USA USA NNP cord-325325-xw7627x9 185 22 , , , cord-325325-xw7627x9 185 23 include include VBP cord-325325-xw7627x9 185 24 200 200 CD cord-325325-xw7627x9 185 25 million million CD cord-325325-xw7627x9 185 26 people people NNS cord-325325-xw7627x9 185 27 infected infect VBN cord-325325-xw7627x9 185 28 , , , cord-325325-xw7627x9 185 29 90 90 CD cord-325325-xw7627x9 185 30 million million CD cord-325325-xw7627x9 185 31 clinically clinically RB cord-325325-xw7627x9 185 32 ill ill JJ cord-325325-xw7627x9 185 33 , , , cord-325325-xw7627x9 185 34 and and CC cord-325325-xw7627x9 185 35 2 2 CD cord-325325-xw7627x9 185 36 million million CD cord-325325-xw7627x9 185 37 dead dead JJ cord-325325-xw7627x9 185 38 . . . cord-325325-xw7627x9 186 1 The the DT cord-325325-xw7627x9 186 2 study study NN cord-325325-xw7627x9 186 3 estimated estimate VBD cord-325325-xw7627x9 186 4 that that IN cord-325325-xw7627x9 186 5 30 30 CD cord-325325-xw7627x9 186 6 % % NN cord-325325-xw7627x9 186 7 of of IN cord-325325-xw7627x9 186 8 all all DT cord-325325-xw7627x9 186 9 workers worker NNS cord-325325-xw7627x9 186 10 would would MD cord-325325-xw7627x9 186 11 become become VB cord-325325-xw7627x9 186 12 ill ill JJ cord-325325-xw7627x9 186 13 and and CC cord-325325-xw7627x9 186 14 2.5 2.5 CD cord-325325-xw7627x9 186 15 % % NN cord-325325-xw7627x9 186 16 would would MD cord-325325-xw7627x9 186 17 die die VB cord-325325-xw7627x9 186 18 , , , cord-325325-xw7627x9 186 19 resulting result VBG cord-325325-xw7627x9 186 20 in in IN cord-325325-xw7627x9 186 21 a a DT cord-325325-xw7627x9 186 22 decrease decrease NN cord-325325-xw7627x9 186 23 in in IN cord-325325-xw7627x9 186 24 the the DT cord-325325-xw7627x9 186 25 gross gross JJ cord-325325-xw7627x9 186 26 domestic domestic JJ cord-325325-xw7627x9 186 27 product product NN cord-325325-xw7627x9 186 28 of of IN cord-325325-xw7627x9 186 29 5 5 CD cord-325325-xw7627x9 186 30 % % NN cord-325325-xw7627x9 186 31 . . . cord-325325-xw7627x9 187 1 Furthermore furthermore RB cord-325325-xw7627x9 187 2 , , , cord-325325-xw7627x9 187 3 18 18 CD cord-325325-xw7627x9 187 4 to to TO cord-325325-xw7627x9 187 5 45 45 CD cord-325325-xw7627x9 187 6 million million CD cord-325325-xw7627x9 187 7 people people NNS cord-325325-xw7627x9 187 8 would would MD cord-325325-xw7627x9 187 9 require require VB cord-325325-xw7627x9 187 10 outpatient outpatient NN cord-325325-xw7627x9 187 11 care care NN cord-325325-xw7627x9 187 12 , , , cord-325325-xw7627x9 187 13 and and CC cord-325325-xw7627x9 187 14 the the DT cord-325325-xw7627x9 187 15 economic economic JJ cord-325325-xw7627x9 187 16 cost cost NN cord-325325-xw7627x9 187 17 would would MD cord-325325-xw7627x9 187 18 total total VB cord-325325-xw7627x9 187 19 approximately approximately RB cord-325325-xw7627x9 187 20 $ $ $ cord-325325-xw7627x9 187 21 675 675 CD cord-325325-xw7627x9 187 22 billion billion CD cord-325325-xw7627x9 187 23 . . . cord-325325-xw7627x9 188 1 64 64 CD cord-325325-xw7627x9 188 2 _SP cord-325325-xw7627x9 189 1 The the DT cord-325325-xw7627x9 189 2 world world NN cord-325325-xw7627x9 189 3 is be VBZ cord-325325-xw7627x9 189 4 facing face VBG cord-325325-xw7627x9 189 5 the the DT cord-325325-xw7627x9 189 6 real real JJ cord-325325-xw7627x9 189 7 threat threat NN cord-325325-xw7627x9 189 8 of of IN cord-325325-xw7627x9 189 9 another another DT cord-325325-xw7627x9 189 10 influenza influenza NN cord-325325-xw7627x9 189 11 pandemic pandemic NN cord-325325-xw7627x9 189 12 with with IN cord-325325-xw7627x9 189 13 a a DT cord-325325-xw7627x9 189 14 virus virus NN cord-325325-xw7627x9 189 15 that that WDT cord-325325-xw7627x9 189 16 has have VBZ cord-325325-xw7627x9 189 17 a a DT cord-325325-xw7627x9 189 18 great great JJ cord-325325-xw7627x9 189 19 pathogenicity pathogenicity NN cord-325325-xw7627x9 189 20 and and CC cord-325325-xw7627x9 189 21 a a DT cord-325325-xw7627x9 189 22 mortality mortality NN cord-325325-xw7627x9 189 23 rate rate NN cord-325325-xw7627x9 189 24 in in IN cord-325325-xw7627x9 189 25 humans human NNS cord-325325-xw7627x9 189 26 exceeding exceed VBG cord-325325-xw7627x9 189 27 50 50 CD cord-325325-xw7627x9 189 28 % % NN cord-325325-xw7627x9 189 29 . . . cord-325325-xw7627x9 190 1 Despite despite IN cord-325325-xw7627x9 190 2 the the DT cord-325325-xw7627x9 190 3 high high JJ cord-325325-xw7627x9 190 4 level level NN cord-325325-xw7627x9 190 5 of of IN cord-325325-xw7627x9 190 6 technology technology NN cord-325325-xw7627x9 190 7 and and CC cord-325325-xw7627x9 190 8 ongoing ongoing JJ cord-325325-xw7627x9 190 9 research research NN cord-325325-xw7627x9 190 10 , , , cord-325325-xw7627x9 190 11 at at IN cord-325325-xw7627x9 190 12 the the DT cord-325325-xw7627x9 190 13 present present JJ cord-325325-xw7627x9 190 14 time time NN cord-325325-xw7627x9 190 15 there there EX cord-325325-xw7627x9 190 16 is be VBZ cord-325325-xw7627x9 190 17 no no DT cord-325325-xw7627x9 190 18 highly highly RB cord-325325-xw7627x9 190 19 effective effective JJ cord-325325-xw7627x9 190 20 vaccine vaccine NN cord-325325-xw7627x9 190 21 against against IN cord-325325-xw7627x9 190 22 avian avian JJ cord-325325-xw7627x9 190 23 influenza influenza NN cord-325325-xw7627x9 190 24 H5N1 H5N1 NNP cord-325325-xw7627x9 190 25 virus virus NN cord-325325-xw7627x9 190 26 that that WDT cord-325325-xw7627x9 190 27 can can MD cord-325325-xw7627x9 190 28 be be VB cord-325325-xw7627x9 190 29 manufactured manufacture VBN cord-325325-xw7627x9 190 30 commercially commercially RB cord-325325-xw7627x9 190 31 on on IN cord-325325-xw7627x9 190 32 a a DT cord-325325-xw7627x9 190 33 large large JJ cord-325325-xw7627x9 190 34 scale scale NN cord-325325-xw7627x9 190 35 for for IN cord-325325-xw7627x9 190 36 use use NN cord-325325-xw7627x9 190 37 at at IN cord-325325-xw7627x9 190 38 low low JJ cord-325325-xw7627x9 190 39 doses dose NNS cord-325325-xw7627x9 190 40 . . . cord-325325-xw7627x9 191 1 As as IN cord-325325-xw7627x9 191 2 is be VBZ cord-325325-xw7627x9 191 3 always always RB cord-325325-xw7627x9 191 4 said say VBN cord-325325-xw7627x9 191 5 , , , cord-325325-xw7627x9 191 6 ' ' '' cord-325325-xw7627x9 191 7 ' ' '' cord-325325-xw7627x9 191 8 a a DT cord-325325-xw7627x9 191 9 dime dime NN cord-325325-xw7627x9 191 10 of of IN cord-325325-xw7627x9 191 11 prevention prevention NN cord-325325-xw7627x9 191 12 is be VBZ cord-325325-xw7627x9 191 13 better well JJR cord-325325-xw7627x9 191 14 than than IN cord-325325-xw7627x9 191 15 a a DT cord-325325-xw7627x9 191 16 pound pound NN cord-325325-xw7627x9 191 17 of of IN cord-325325-xw7627x9 191 18 treatment treatment NN cord-325325-xw7627x9 191 19 ' ' '' cord-325325-xw7627x9 191 20 ' ' '' cord-325325-xw7627x9 191 21 . . . cord-325325-xw7627x9 192 1 Responsibility responsibility NN cord-325325-xw7627x9 192 2 should should MD cord-325325-xw7627x9 192 3 be be VB cord-325325-xw7627x9 192 4 taken take VBN cord-325325-xw7627x9 192 5 at at IN cord-325325-xw7627x9 192 6 all all DT cord-325325-xw7627x9 192 7 levels level NNS cord-325325-xw7627x9 192 8 and and CC cord-325325-xw7627x9 192 9 preventative preventative JJ cord-325325-xw7627x9 192 10 steps step NNS cord-325325-xw7627x9 192 11 should should MD cord-325325-xw7627x9 192 12 be be VB cord-325325-xw7627x9 192 13 implemented implement VBN cord-325325-xw7627x9 192 14 immediately immediately RB cord-325325-xw7627x9 192 15 . . . cord-325325-xw7627x9 193 1 Healthcare healthcare NN cord-325325-xw7627x9 193 2 providers provider NNS cord-325325-xw7627x9 193 3 should should MD cord-325325-xw7627x9 193 4 be be VB cord-325325-xw7627x9 193 5 up up RB cord-325325-xw7627x9 193 6 - - HYPH cord-325325-xw7627x9 193 7 to to IN cord-325325-xw7627x9 193 8 - - HYPH cord-325325-xw7627x9 193 9 date date NN cord-325325-xw7627x9 193 10 with with IN cord-325325-xw7627x9 193 11 the the DT cord-325325-xw7627x9 193 12 pandemic pandemic NN cord-325325-xw7627x9 193 13 risk risk NN cord-325325-xw7627x9 193 14 and and CC cord-325325-xw7627x9 193 15 educate educate VB cord-325325-xw7627x9 193 16 their -PRON- PRP$ cord-325325-xw7627x9 193 17 patients patient NNS cord-325325-xw7627x9 193 18 . . . cord-325325-xw7627x9 194 1 Such such JJ cord-325325-xw7627x9 194 2 information information NN cord-325325-xw7627x9 194 3 can can MD cord-325325-xw7627x9 194 4 be be VB cord-325325-xw7627x9 194 5 found find VBN cord-325325-xw7627x9 194 6 at at IN cord-325325-xw7627x9 194 7 www.cdc.gov/flu www.cdc.gov/flu PRP cord-325325-xw7627x9 194 8 . . . cord-325325-xw7627x9 195 1 Other other JJ cord-325325-xw7627x9 195 2 sources source NNS cord-325325-xw7627x9 195 3 of of IN cord-325325-xw7627x9 195 4 information information NN cord-325325-xw7627x9 195 5 include include VBP cord-325325-xw7627x9 195 6 www.defra.gov.uk www.defra.gov.uk NNS cord-325325-xw7627x9 195 7 , , , cord-325325-xw7627x9 195 8 www.fda.gov www.fda.gov NNP cord-325325-xw7627x9 195 9 , , , cord-325325-xw7627x9 195 10 www.who.int www.who.int NNP cord-325325-xw7627x9 195 11 , , , cord-325325-xw7627x9 195 12 and and CC cord-325325-xw7627x9 195 13 www.eurosurveillance.org www.eurosurveillance.org NN cord-325325-xw7627x9 195 14 . . . cord-325325-xw7627x9 196 1 Conflict conflict NN cord-325325-xw7627x9 196 2 of of IN cord-325325-xw7627x9 196 3 interest interest NN cord-325325-xw7627x9 196 4 : : : cord-325325-xw7627x9 196 5 No no DT cord-325325-xw7627x9 196 6 conflict conflict NN cord-325325-xw7627x9 196 7 of of IN cord-325325-xw7627x9 196 8 interest interest NN cord-325325-xw7627x9 196 9 to to TO cord-325325-xw7627x9 196 10 declare declare VB cord-325325-xw7627x9 196 11 . . . cord-325325-xw7627x9 197 1 Harrison Harrison NNP cord-325325-xw7627x9 197 2 's 's POS cord-325325-xw7627x9 197 3 principles principle NNS cord-325325-xw7627x9 197 4 of of IN cord-325325-xw7627x9 197 5 internal internal JJ cord-325325-xw7627x9 197 6 medicine medicine NN cord-325325-xw7627x9 197 7 Evolution evolution NN cord-325325-xw7627x9 197 8 and and CC cord-325325-xw7627x9 197 9 ecology ecology NN cord-325325-xw7627x9 197 10 of of IN cord-325325-xw7627x9 197 11 influenza influenza NN cord-325325-xw7627x9 197 12 A a NN cord-325325-xw7627x9 197 13 viruses virus NNS cord-325325-xw7627x9 197 14 Global global JJ cord-325325-xw7627x9 197 15 epidemiology epidemiology NN cord-325325-xw7627x9 197 16 of of IN cord-325325-xw7627x9 197 17 influenza influenza NN cord-325325-xw7627x9 197 18 : : : cord-325325-xw7627x9 197 19 past past JJ cord-325325-xw7627x9 197 20 and and CC cord-325325-xw7627x9 197 21 present present JJ cord-325325-xw7627x9 197 22 Influenza Influenza NNP cord-325325-xw7627x9 197 23 virus virus NN cord-325325-xw7627x9 197 24 neuraminidase neuraminidase NN cord-325325-xw7627x9 197 25 inhibitors inhibitor NNS cord-325325-xw7627x9 197 26 Influenza Influenza NNP cord-325325-xw7627x9 197 27 virus virus NN cord-325325-xw7627x9 197 28 antigens antigen NNS cord-325325-xw7627x9 197 29 and and CC cord-325325-xw7627x9 197 30 ' ' `` cord-325325-xw7627x9 197 31 antigenic antigenic JJ cord-325325-xw7627x9 197 32 drift drift NN cord-325325-xw7627x9 197 33 Analysis Analysis NNP cord-325325-xw7627x9 197 34 of of IN cord-325325-xw7627x9 197 35 antigenic antigenic JJ cord-325325-xw7627x9 197 36 drift drift NN cord-325325-xw7627x9 197 37 in in IN cord-325325-xw7627x9 197 38 recently recently RB cord-325325-xw7627x9 197 39 isolated isolate VBN cord-325325-xw7627x9 197 40 influenza influenza NN cord-325325-xw7627x9 197 41 A a NN cord-325325-xw7627x9 197 42 ( ( -LRB- cord-325325-xw7627x9 197 43 H1N1 H1N1 NNP cord-325325-xw7627x9 197 44 ) ) -RRB- cord-325325-xw7627x9 197 45 viruses virus NNS cord-325325-xw7627x9 197 46 using use VBG cord-325325-xw7627x9 197 47 monoclonal monoclonal JJ cord-325325-xw7627x9 197 48 antibody antibody NN cord-325325-xw7627x9 197 49 preparations preparation NNS cord-325325-xw7627x9 197 50 Influenza Influenza NNP cord-325325-xw7627x9 197 51 -- -- : cord-325325-xw7627x9 197 52 a a DT cord-325325-xw7627x9 197 53 model model NN cord-325325-xw7627x9 197 54 of of IN cord-325325-xw7627x9 197 55 an an DT cord-325325-xw7627x9 197 56 emerging emerge VBG cord-325325-xw7627x9 197 57 virus virus NN cord-325325-xw7627x9 197 58 disease disease NN cord-325325-xw7627x9 197 59 Enhanced enhance VBN cord-325325-xw7627x9 197 60 virulence virulence NN cord-325325-xw7627x9 197 61 of of IN cord-325325-xw7627x9 197 62 influenza influenza NN cord-325325-xw7627x9 197 63 A a DT cord-325325-xw7627x9 197 64 viruses virus NNS cord-325325-xw7627x9 197 65 with with IN cord-325325-xw7627x9 197 66 the the DT cord-325325-xw7627x9 197 67 haemagglutinin haemagglutinin NNP cord-325325-xw7627x9 197 68 of of IN cord-325325-xw7627x9 197 69 the the DT cord-325325-xw7627x9 197 70 1918 1918 CD cord-325325-xw7627x9 197 71 pandemic pandemic NNP cord-325325-xw7627x9 197 72 virus virus NN cord-325325-xw7627x9 198 1 The the DT cord-325325-xw7627x9 198 2 genetic genetic JJ cord-325325-xw7627x9 198 3 archaeology archaeology NN cord-325325-xw7627x9 198 4 of of IN cord-325325-xw7627x9 198 5 influenza influenza NN cord-325325-xw7627x9 198 6 Characterization characterization NN cord-325325-xw7627x9 198 7 of of IN cord-325325-xw7627x9 198 8 the the DT cord-325325-xw7627x9 198 9 reconstructed reconstruct VBN cord-325325-xw7627x9 198 10 1918 1918 CD cord-325325-xw7627x9 198 11 Spanish spanish JJ cord-325325-xw7627x9 198 12 influenza influenza NN cord-325325-xw7627x9 198 13 pandemic pandemic NN cord-325325-xw7627x9 198 14 virus virus NN cord-325325-xw7627x9 198 15 Transmissibility transmissibility NN cord-325325-xw7627x9 198 16 of of IN cord-325325-xw7627x9 198 17 1918 1918 CD cord-325325-xw7627x9 198 18 pandemic pandemic NN cord-325325-xw7627x9 198 19 influenza influenza NN cord-325325-xw7627x9 199 1 The the DT cord-325325-xw7627x9 199 2 threat threat NN cord-325325-xw7627x9 199 3 of of IN cord-325325-xw7627x9 199 4 an an DT cord-325325-xw7627x9 199 5 avian avian JJ cord-325325-xw7627x9 199 6 influenza influenza NN cord-325325-xw7627x9 199 7 pandemic pandemic NN cord-325325-xw7627x9 199 8 On on IN cord-325325-xw7627x9 199 9 the the DT cord-325325-xw7627x9 199 10 origin origin NN cord-325325-xw7627x9 199 11 of of IN cord-325325-xw7627x9 199 12 the the DT cord-325325-xw7627x9 199 13 human human JJ cord-325325-xw7627x9 199 14 influenza influenza NN cord-325325-xw7627x9 199 15 subtypes subtype NNS cord-325325-xw7627x9 199 16 H2N2 H2N2 NNP cord-325325-xw7627x9 199 17 and and CC cord-325325-xw7627x9 199 18 H3N2 H3N2 NNP cord-325325-xw7627x9 199 19 Avian Avian NNP cord-325325-xw7627x9 199 20 - - HYPH cord-325325-xw7627x9 199 21 to to IN cord-325325-xw7627x9 199 22 - - HYPH cord-325325-xw7627x9 199 23 human human JJ cord-325325-xw7627x9 199 24 transmission transmission NN cord-325325-xw7627x9 199 25 of of IN cord-325325-xw7627x9 199 26 the the DT cord-325325-xw7627x9 199 27 PB1 PB1 NNP cord-325325-xw7627x9 199 28 gene gene NN cord-325325-xw7627x9 199 29 of of IN cord-325325-xw7627x9 199 30 influenza influenza NN cord-325325-xw7627x9 199 31 A a DT cord-325325-xw7627x9 199 32 viruses virus NNS cord-325325-xw7627x9 199 33 in in IN cord-325325-xw7627x9 199 34 the the DT cord-325325-xw7627x9 199 35 1957 1957 CD cord-325325-xw7627x9 199 36 and and CC cord-325325-xw7627x9 199 37 1968 1968 CD cord-325325-xw7627x9 199 38 pandemics pandemic NNS cord-325325-xw7627x9 199 39 Questions question NNS cord-325325-xw7627x9 199 40 and and CC cord-325325-xw7627x9 199 41 answers answer NNS cord-325325-xw7627x9 199 42 about about IN cord-325325-xw7627x9 199 43 avian avian JJ cord-325325-xw7627x9 199 44 influenza influenza NN cord-325325-xw7627x9 199 45 ( ( -LRB- cord-325325-xw7627x9 199 46 bird bird NN cord-325325-xw7627x9 199 47 flu flu NN cord-325325-xw7627x9 199 48 ) ) -RRB- cord-325325-xw7627x9 199 49 and and CC cord-325325-xw7627x9 199 50 avian avian JJ cord-325325-xw7627x9 199 51 influenza influenza NN cord-325325-xw7627x9 199 52 A a NN cord-325325-xw7627x9 199 53 ( ( -LRB- cord-325325-xw7627x9 199 54 H5N1 H5N1 NNP cord-325325-xw7627x9 199 55 ) ) -RRB- cord-325325-xw7627x9 199 56 virus virus NN cord-325325-xw7627x9 199 57 Clinical clinical JJ cord-325325-xw7627x9 199 58 features feature NNS cord-325325-xw7627x9 199 59 and and CC cord-325325-xw7627x9 199 60 rapid rapid JJ cord-325325-xw7627x9 199 61 viral viral JJ cord-325325-xw7627x9 199 62 diagnosis diagnosis NN cord-325325-xw7627x9 199 63 of of IN cord-325325-xw7627x9 199 64 human human JJ cord-325325-xw7627x9 199 65 disease disease NN cord-325325-xw7627x9 199 66 associated associate VBN cord-325325-xw7627x9 199 67 with with IN cord-325325-xw7627x9 199 68 avian avian JJ cord-325325-xw7627x9 199 69 influenza influenza NN cord-325325-xw7627x9 199 70 A a DT cord-325325-xw7627x9 199 71 H5N1 H5N1 NNP cord-325325-xw7627x9 199 72 virus virus NN cord-325325-xw7627x9 199 73 Avian Avian NNP cord-325325-xw7627x9 199 74 H5N1 H5N1 NNP cord-325325-xw7627x9 199 75 influenza influenza NN cord-325325-xw7627x9 199 76 in in IN cord-325325-xw7627x9 199 77 cats cat NNS cord-325325-xw7627x9 199 78 Avian avian JJ cord-325325-xw7627x9 199 79 influenza influenza NN cord-325325-xw7627x9 199 80 H5N1 H5N1 NNP cord-325325-xw7627x9 199 81 in in IN cord-325325-xw7627x9 199 82 tigers tiger NNS cord-325325-xw7627x9 199 83 and and CC cord-325325-xw7627x9 199 84 leopards leopard NNS cord-325325-xw7627x9 199 85 Cumulative cumulative JJ cord-325325-xw7627x9 199 86 number number NN cord-325325-xw7627x9 199 87 of of IN cord-325325-xw7627x9 199 88 confirmed confirm VBN cord-325325-xw7627x9 199 89 human human JJ cord-325325-xw7627x9 199 90 cases case NNS cord-325325-xw7627x9 199 91 of of IN cord-325325-xw7627x9 199 92 avian avian JJ cord-325325-xw7627x9 199 93 influenza influenza NN cord-325325-xw7627x9 199 94 A/(H5N1 A/(H5N1 NNP cord-325325-xw7627x9 199 95 ) ) -RRB- cord-325325-xw7627x9 199 96 reported report VBD cord-325325-xw7627x9 199 97 to to IN cord-325325-xw7627x9 199 98 WHO who WP cord-325325-xw7627x9 199 99 Avian avian JJ cord-325325-xw7627x9 199 100 influenza influenza NN cord-325325-xw7627x9 199 101 frequently frequently RB cord-325325-xw7627x9 199 102 asked ask VBD cord-325325-xw7627x9 199 103 questions question NNS cord-325325-xw7627x9 199 104 Probable probable JJ cord-325325-xw7627x9 199 105 person person NN cord-325325-xw7627x9 199 106 - - HYPH cord-325325-xw7627x9 199 107 to to IN cord-325325-xw7627x9 199 108 - - HYPH cord-325325-xw7627x9 199 109 person person NN cord-325325-xw7627x9 199 110 transmission transmission NN cord-325325-xw7627x9 199 111 of of IN cord-325325-xw7627x9 199 112 avian avian JJ cord-325325-xw7627x9 199 113 influenza influenza NN cord-325325-xw7627x9 199 114 A a NN cord-325325-xw7627x9 199 115 ( ( -LRB- cord-325325-xw7627x9 199 116 H5N1 H5N1 NNP cord-325325-xw7627x9 199 117 ) ) -RRB- cord-325325-xw7627x9 199 118 Transmission transmission NN cord-325325-xw7627x9 199 119 of of IN cord-325325-xw7627x9 199 120 avian avian JJ cord-325325-xw7627x9 199 121 influenza influenza NN cord-325325-xw7627x9 199 122 viruses virus NNS cord-325325-xw7627x9 199 123 to to IN cord-325325-xw7627x9 199 124 and and CC cord-325325-xw7627x9 199 125 between between IN cord-325325-xw7627x9 199 126 humans human NNS cord-325325-xw7627x9 200 1 Avian avian JJ cord-325325-xw7627x9 200 2 influenza influenza NN cord-325325-xw7627x9 200 3 A a NN cord-325325-xw7627x9 200 4 ( ( -LRB- cord-325325-xw7627x9 200 5 H5N1 H5N1 NNP cord-325325-xw7627x9 200 6 ) ) -RRB- cord-325325-xw7627x9 200 7 infection infection NN cord-325325-xw7627x9 200 8 in in IN cord-325325-xw7627x9 200 9 humans human NNS cord-325325-xw7627x9 201 1 H5N1 H5N1 NNP cord-325325-xw7627x9 201 2 influenza influenza NN cord-325325-xw7627x9 201 3 : : : cord-325325-xw7627x9 201 4 a a DT cord-325325-xw7627x9 201 5 protean protean JJ cord-325325-xw7627x9 201 6 pandemic pandemic NN cord-325325-xw7627x9 201 7 threat threat NN cord-325325-xw7627x9 201 8 Molecular molecular JJ cord-325325-xw7627x9 201 9 basis basis NN cord-325325-xw7627x9 201 10 for for IN cord-325325-xw7627x9 201 11 high high JJ cord-325325-xw7627x9 201 12 virulence virulence NN cord-325325-xw7627x9 201 13 of of IN cord-325325-xw7627x9 201 14 Hong Hong NNP cord-325325-xw7627x9 201 15 Kong Kong NNP cord-325325-xw7627x9 201 16 H5N1 H5N1 NNP cord-325325-xw7627x9 202 1 influenza influenza NN cord-325325-xw7627x9 202 2 A a DT cord-325325-xw7627x9 202 3 viruses virus NNS cord-325325-xw7627x9 203 1 PB2 pb2 NN cord-325325-xw7627x9 203 2 amino amino NN cord-325325-xw7627x9 203 3 acid acid NN cord-325325-xw7627x9 203 4 at at IN cord-325325-xw7627x9 203 5 position position NN cord-325325-xw7627x9 203 6 627 627 CD cord-325325-xw7627x9 203 7 affects affect VBZ cord-325325-xw7627x9 203 8 replicative replicative JJ cord-325325-xw7627x9 203 9 efficiency efficiency NN cord-325325-xw7627x9 203 10 , , , cord-325325-xw7627x9 203 11 but but CC cord-325325-xw7627x9 203 12 not not RB cord-325325-xw7627x9 203 13 cell cell NN cord-325325-xw7627x9 203 14 tropism tropism NN cord-325325-xw7627x9 203 15 , , , cord-325325-xw7627x9 203 16 of of IN cord-325325-xw7627x9 203 17 Hong Hong NNP cord-325325-xw7627x9 203 18 Kong Kong NNP cord-325325-xw7627x9 203 19 H5N1 H5N1 NNP cord-325325-xw7627x9 204 1 influenza influenza NN cord-325325-xw7627x9 204 2 A a DT cord-325325-xw7627x9 204 3 viruses virus NNS cord-325325-xw7627x9 204 4 in in IN cord-325325-xw7627x9 204 5 mice mouse NNS cord-325325-xw7627x9 204 6 Lethal Lethal NNP cord-325325-xw7627x9 204 7 H5N1 H5N1 NNP cord-325325-xw7627x9 204 8 influenza influenza NN cord-325325-xw7627x9 204 9 viruses virus NNS cord-325325-xw7627x9 204 10 escape escape VBP cord-325325-xw7627x9 204 11 host host NN cord-325325-xw7627x9 204 12 anti anti JJ cord-325325-xw7627x9 204 13 - - JJ cord-325325-xw7627x9 204 14 viral viral JJ cord-325325-xw7627x9 204 15 cytokine cytokine NN cord-325325-xw7627x9 204 16 responses response NNS cord-325325-xw7627x9 204 17 Induction Induction NNP cord-325325-xw7627x9 204 18 of of IN cord-325325-xw7627x9 204 19 proinflammatory proinflammatory JJ cord-325325-xw7627x9 204 20 cytokines cytokine NNS cord-325325-xw7627x9 204 21 in in IN cord-325325-xw7627x9 204 22 human human JJ cord-325325-xw7627x9 204 23 macrophages macrophage NNS cord-325325-xw7627x9 204 24 by by IN cord-325325-xw7627x9 204 25 influenza influenza NN cord-325325-xw7627x9 204 26 A a NN cord-325325-xw7627x9 204 27 ( ( -LRB- cord-325325-xw7627x9 204 28 H5N1 H5N1 NNP cord-325325-xw7627x9 204 29 ) ) -RRB- cord-325325-xw7627x9 204 30 viruses virus NNS cord-325325-xw7627x9 204 31 : : : cord-325325-xw7627x9 204 32 a a DT cord-325325-xw7627x9 204 33 mechanism mechanism NN cord-325325-xw7627x9 204 34 for for IN cord-325325-xw7627x9 204 35 the the DT cord-325325-xw7627x9 204 36 unusual unusual JJ cord-325325-xw7627x9 204 37 severity severity NN cord-325325-xw7627x9 204 38 of of IN cord-325325-xw7627x9 204 39 human human JJ cord-325325-xw7627x9 204 40 disease disease NN cord-325325-xw7627x9 204 41 ? ? . cord-325325-xw7627x9 205 1 Re Re NNS cord-325325-xw7627x9 205 2 - - NN cord-325325-xw7627x9 205 3 emergence emergence NN cord-325325-xw7627x9 205 4 of of IN cord-325325-xw7627x9 205 5 fatal fatal JJ cord-325325-xw7627x9 205 6 human human JJ cord-325325-xw7627x9 205 7 influenza influenza NN cord-325325-xw7627x9 205 8 A a DT cord-325325-xw7627x9 205 9 subtype subtype NN cord-325325-xw7627x9 206 1 H5N1 H5N1 NNP cord-325325-xw7627x9 206 2 disease disease NN cord-325325-xw7627x9 207 1 Avian avian JJ cord-325325-xw7627x9 207 2 influenza influenza NN cord-325325-xw7627x9 207 3 : : : cord-325325-xw7627x9 207 4 an an DT cord-325325-xw7627x9 207 5 emerging emerge VBG cord-325325-xw7627x9 207 6 pandemic pandemic NN cord-325325-xw7627x9 207 7 threat threat NN cord-325325-xw7627x9 207 8 Avian avian JJ cord-325325-xw7627x9 207 9 influenza influenza NN cord-325325-xw7627x9 207 10 in in IN cord-325325-xw7627x9 207 11 Hong Hong NNP cord-325325-xw7627x9 207 12 Kong Kong NNP cord-325325-xw7627x9 207 13 Antigenic Antigenic NNP cord-325325-xw7627x9 207 14 differences difference NNS cord-325325-xw7627x9 207 15 between between IN cord-325325-xw7627x9 207 16 H5N1 H5N1 NNP cord-325325-xw7627x9 207 17 human human JJ cord-325325-xw7627x9 207 18 influenza influenza NN cord-325325-xw7627x9 207 19 viruses virus NNS cord-325325-xw7627x9 207 20 isolated isolate VBN cord-325325-xw7627x9 207 21 in in IN cord-325325-xw7627x9 207 22 1997 1997 CD cord-325325-xw7627x9 207 23 and and CC cord-325325-xw7627x9 207 24 Antibody Antibody NNP cord-325325-xw7627x9 207 25 response response NN cord-325325-xw7627x9 207 26 in in IN cord-325325-xw7627x9 207 27 individuals individual NNS cord-325325-xw7627x9 207 28 infected infect VBN cord-325325-xw7627x9 207 29 with with IN cord-325325-xw7627x9 207 30 avian avian JJ cord-325325-xw7627x9 207 31 influenza influenza NN cord-325325-xw7627x9 207 32 A a NN cord-325325-xw7627x9 207 33 ( ( -LRB- cord-325325-xw7627x9 207 34 H5N1 H5N1 NNP cord-325325-xw7627x9 207 35 ) ) -RRB- cord-325325-xw7627x9 207 36 viruses virus NNS cord-325325-xw7627x9 207 37 and and CC cord-325325-xw7627x9 207 38 detection detection NN cord-325325-xw7627x9 207 39 of of IN cord-325325-xw7627x9 207 40 anti anti JJ cord-325325-xw7627x9 207 41 - - JJ cord-325325-xw7627x9 207 42 H5 h5 JJ cord-325325-xw7627x9 207 43 antibody antibody NN cord-325325-xw7627x9 207 44 among among IN cord-325325-xw7627x9 207 45 household household NN cord-325325-xw7627x9 207 46 and and CC cord-325325-xw7627x9 207 47 social social JJ cord-325325-xw7627x9 207 48 contacts contact NNS cord-325325-xw7627x9 207 49 Fatal fatal JJ cord-325325-xw7627x9 207 50 avian avian JJ cord-325325-xw7627x9 207 51 influenza influenza NN cord-325325-xw7627x9 207 52 A a NN cord-325325-xw7627x9 207 53 ( ( -LRB- cord-325325-xw7627x9 207 54 H5N1 H5N1 NNP cord-325325-xw7627x9 207 55 ) ) -RRB- cord-325325-xw7627x9 207 56 in in IN cord-325325-xw7627x9 207 57 a a DT cord-325325-xw7627x9 207 58 child child NN cord-325325-xw7627x9 207 59 presenting present VBG cord-325325-xw7627x9 207 60 with with IN cord-325325-xw7627x9 207 61 diarrhea diarrhea NN cord-325325-xw7627x9 207 62 followed follow VBN cord-325325-xw7627x9 207 63 by by IN cord-325325-xw7627x9 207 64 coma coma NN cord-325325-xw7627x9 207 65 Human human JJ cord-325325-xw7627x9 207 66 disease disease NN cord-325325-xw7627x9 207 67 from from IN cord-325325-xw7627x9 207 68 influenza influenza NN cord-325325-xw7627x9 207 69 A A NNP cord-325325-xw7627x9 207 70 ( ( -LRB- cord-325325-xw7627x9 207 71 H5N1 H5N1 NNP cord-325325-xw7627x9 207 72 ) ) -RRB- cord-325325-xw7627x9 207 73 Detection detection NN cord-325325-xw7627x9 207 74 of of IN cord-325325-xw7627x9 207 75 antibody antibody NN cord-325325-xw7627x9 207 76 to to IN cord-325325-xw7627x9 207 77 avian avian JJ cord-325325-xw7627x9 207 78 influenza influenza NN cord-325325-xw7627x9 207 79 A a NN cord-325325-xw7627x9 207 80 ( ( -LRB- cord-325325-xw7627x9 207 81 H5N1 H5N1 NNP cord-325325-xw7627x9 207 82 ) ) -RRB- cord-325325-xw7627x9 207 83 virus virus NN cord-325325-xw7627x9 207 84 in in IN cord-325325-xw7627x9 207 85 human human JJ cord-325325-xw7627x9 207 86 serum serum NN cord-325325-xw7627x9 207 87 by by IN cord-325325-xw7627x9 207 88 using use VBG cord-325325-xw7627x9 207 89 a a DT cord-325325-xw7627x9 207 90 combination combination NN cord-325325-xw7627x9 207 91 of of IN cord-325325-xw7627x9 207 92 serologic serologic JJ cord-325325-xw7627x9 207 93 assays assay NNS cord-325325-xw7627x9 207 94 World World NNP cord-325325-xw7627x9 207 95 Health Health NNP cord-325325-xw7627x9 207 96 Organization Organization NNP cord-325325-xw7627x9 207 97 . . . cord-325325-xw7627x9 208 1 WHO who WP cord-325325-xw7627x9 208 2 interim interim JJ cord-325325-xw7627x9 208 3 guidelines guideline NNS cord-325325-xw7627x9 208 4 on on IN cord-325325-xw7627x9 208 5 clinical clinical JJ cord-325325-xw7627x9 208 6 management management NN cord-325325-xw7627x9 208 7 of of IN cord-325325-xw7627x9 208 8 humans human NNS cord-325325-xw7627x9 208 9 infected infect VBN cord-325325-xw7627x9 208 10 by by IN cord-325325-xw7627x9 208 11 influenza influenza NN cord-325325-xw7627x9 208 12 A a NN cord-325325-xw7627x9 208 13 ( ( -LRB- cord-325325-xw7627x9 208 14 H5N1 H5N1 NNP cord-325325-xw7627x9 208 15 ) ) -RRB- cord-325325-xw7627x9 208 16 Virulence Virulence NNP cord-325325-xw7627x9 208 17 may may MD cord-325325-xw7627x9 208 18 determine determine VB cord-325325-xw7627x9 208 19 the the DT cord-325325-xw7627x9 208 20 necessary necessary JJ cord-325325-xw7627x9 208 21 duration duration NN cord-325325-xw7627x9 208 22 and and CC cord-325325-xw7627x9 208 23 dosage dosage NN cord-325325-xw7627x9 208 24 of of IN cord-325325-xw7627x9 208 25 oseltamivir oseltamivir JJ cord-325325-xw7627x9 208 26 treatment treatment NN cord-325325-xw7627x9 208 27 for for IN cord-325325-xw7627x9 208 28 highly highly RB cord-325325-xw7627x9 208 29 pathogenic pathogenic JJ cord-325325-xw7627x9 208 30 A A NNP cord-325325-xw7627x9 208 31 / / , cord-325325-xw7627x9 208 32 Vietnam/1203/04 vietnam/1203/04 WRB cord-325325-xw7627x9 208 33 influenza influenza NN cord-325325-xw7627x9 208 34 virus virus NN cord-325325-xw7627x9 208 35 in in IN cord-325325-xw7627x9 208 36 mice mouse NNS cord-325325-xw7627x9 208 37 Update update NN cord-325325-xw7627x9 208 38 : : : cord-325325-xw7627x9 208 39 influenza influenza NN cord-325325-xw7627x9 208 40 activity activity NN cord-325325-xw7627x9 208 41 -- -- : cord-325325-xw7627x9 208 42 United United NNP cord-325325-xw7627x9 208 43 States States NNP cord-325325-xw7627x9 208 44 and and CC cord-325325-xw7627x9 208 45 worldwide worldwide RB cord-325325-xw7627x9 208 46 , , , cord-325325-xw7627x9 208 47 2003 2003 CD cord-325325-xw7627x9 208 48 - - SYM cord-325325-xw7627x9 208 49 04 04 CD cord-325325-xw7627x9 208 50 season season NN cord-325325-xw7627x9 208 51 , , , cord-325325-xw7627x9 208 52 and and CC cord-325325-xw7627x9 208 53 composition composition NN cord-325325-xw7627x9 208 54 of of IN cord-325325-xw7627x9 208 55 the the DT cord-325325-xw7627x9 208 56 2004 2004 CD cord-325325-xw7627x9 208 57 - - SYM cord-325325-xw7627x9 208 58 05 05 CD cord-325325-xw7627x9 208 59 influenza influenza NN cord-325325-xw7627x9 208 60 vaccine vaccine NN cord-325325-xw7627x9 208 61 Genesis Genesis NNP cord-325325-xw7627x9 208 62 of of IN cord-325325-xw7627x9 208 63 a a DT cord-325325-xw7627x9 208 64 highly highly RB cord-325325-xw7627x9 208 65 pathogenic pathogenic JJ cord-325325-xw7627x9 208 66 and and CC cord-325325-xw7627x9 208 67 potentially potentially RB cord-325325-xw7627x9 208 68 pandemic pandemic JJ cord-325325-xw7627x9 208 69 H5N1 H5N1 NNP cord-325325-xw7627x9 208 70 influenza influenza NN cord-325325-xw7627x9 208 71 virus virus NN cord-325325-xw7627x9 208 72 in in IN cord-325325-xw7627x9 208 73 eastern eastern JJ cord-325325-xw7627x9 208 74 Asia Asia NNP cord-325325-xw7627x9 208 75 Comparison Comparison NNP cord-325325-xw7627x9 208 76 of of IN cord-325325-xw7627x9 208 77 efficacies efficacy NNS cord-325325-xw7627x9 208 78 of of IN cord-325325-xw7627x9 208 79 RWJ-270201 RWJ-270201 NNP cord-325325-xw7627x9 208 80 , , , cord-325325-xw7627x9 208 81 zanamivir zanamivir NNP cord-325325-xw7627x9 208 82 , , , cord-325325-xw7627x9 208 83 and and CC cord-325325-xw7627x9 208 84 oseltamivir oseltamivir NN cord-325325-xw7627x9 208 85 against against IN cord-325325-xw7627x9 208 86 H5N1 H5N1 NNP cord-325325-xw7627x9 208 87 , , , cord-325325-xw7627x9 208 88 H9N2 H9N2 NNP cord-325325-xw7627x9 208 89 , , , cord-325325-xw7627x9 208 90 and and CC cord-325325-xw7627x9 208 91 other other JJ cord-325325-xw7627x9 208 92 avian avian JJ cord-325325-xw7627x9 208 93 influenza influenza NN cord-325325-xw7627x9 208 94 viruses virus NNS cord-325325-xw7627x9 209 1 Oseltamivir Oseltamivir NNP cord-325325-xw7627x9 209 2 resistance resistance NN cord-325325-xw7627x9 209 3 in in IN cord-325325-xw7627x9 209 4 influenza influenza NN cord-325325-xw7627x9 209 5 A a NN cord-325325-xw7627x9 209 6 ( ( -LRB- cord-325325-xw7627x9 209 7 H5N1 H5N1 NNP cord-325325-xw7627x9 209 8 ) ) -RRB- cord-325325-xw7627x9 209 9 infection infection NN cord-325325-xw7627x9 210 1 The the DT cord-325325-xw7627x9 210 2 run run NN cord-325325-xw7627x9 210 3 on on IN cord-325325-xw7627x9 210 4 tamiflu tamiflu NNP cord-325325-xw7627x9 210 5 -- -- : cord-325325-xw7627x9 210 6 should should MD cord-325325-xw7627x9 210 7 physicians physician NNS cord-325325-xw7627x9 210 8 prescribe prescribe VB cord-325325-xw7627x9 210 9 on on IN cord-325325-xw7627x9 210 10 demand demand NN cord-325325-xw7627x9 210 11 ? ? . cord-325325-xw7627x9 211 1 In in IN cord-325325-xw7627x9 211 2 vitro vitro FW cord-325325-xw7627x9 211 3 inhibitory inhibitory JJ cord-325325-xw7627x9 211 4 effects effect NNS cord-325325-xw7627x9 211 5 of of IN cord-325325-xw7627x9 211 6 combinations combination NNS cord-325325-xw7627x9 211 7 of of IN cord-325325-xw7627x9 211 8 anti anti JJ cord-325325-xw7627x9 211 9 - - JJ cord-325325-xw7627x9 211 10 influenza influenza JJ cord-325325-xw7627x9 211 11 agents agent NNS cord-325325-xw7627x9 212 1 Ribavirin ribavirin RB cord-325325-xw7627x9 212 2 aerosol aerosol NN cord-325325-xw7627x9 212 3 treatment treatment NN cord-325325-xw7627x9 212 4 of of IN cord-325325-xw7627x9 212 5 influenza influenza NN cord-325325-xw7627x9 212 6 Absence absence NN cord-325325-xw7627x9 212 7 of of IN cord-325325-xw7627x9 212 8 interferon interferon NN cord-325325-xw7627x9 212 9 in in IN cord-325325-xw7627x9 212 10 lungs lung NNS cord-325325-xw7627x9 212 11 from from IN cord-325325-xw7627x9 212 12 fatal fatal JJ cord-325325-xw7627x9 212 13 cases case NNS cord-325325-xw7627x9 212 14 of of IN cord-325325-xw7627x9 212 15 influenza influenza NN cord-325325-xw7627x9 212 16 Meta Meta NNP cord-325325-xw7627x9 212 17 - - HYPH cord-325325-xw7627x9 212 18 analysis analysis NN cord-325325-xw7627x9 212 19 : : : cord-325325-xw7627x9 212 20 convalescent convalescent JJ cord-325325-xw7627x9 212 21 blood blood NN cord-325325-xw7627x9 212 22 products product NNS cord-325325-xw7627x9 212 23 for for IN cord-325325-xw7627x9 212 24 Spanish spanish JJ cord-325325-xw7627x9 212 25 influenza influenza NN cord-325325-xw7627x9 212 26 pneumonia pneumonia NN cord-325325-xw7627x9 212 27 : : : cord-325325-xw7627x9 212 28 a a DT cord-325325-xw7627x9 212 29 future future JJ cord-325325-xw7627x9 212 30 H5N1 H5N1 NNP cord-325325-xw7627x9 212 31 treatment treatment NN cord-325325-xw7627x9 212 32 ? ? . cord-325325-xw7627x9 213 1 Management management NN cord-325325-xw7627x9 213 2 of of IN cord-325325-xw7627x9 213 3 influenza influenza NN cord-325325-xw7627x9 213 4 in in IN cord-325325-xw7627x9 213 5 households household NNS cord-325325-xw7627x9 213 6 : : : cord-325325-xw7627x9 213 7 a a DT cord-325325-xw7627x9 213 8 prospective prospective NN cord-325325-xw7627x9 213 9 , , , cord-325325-xw7627x9 213 10 randomized randomized JJ cord-325325-xw7627x9 213 11 comparison comparison NN cord-325325-xw7627x9 213 12 of of IN cord-325325-xw7627x9 213 13 oseltamivir oseltamivir NN cord-325325-xw7627x9 213 14 treatment treatment NN cord-325325-xw7627x9 213 15 with with IN cord-325325-xw7627x9 213 16 or or CC cord-325325-xw7627x9 213 17 without without IN cord-325325-xw7627x9 213 18 postexposure postexposure NN cord-325325-xw7627x9 213 19 prophylaxis prophylaxis NN cord-325325-xw7627x9 213 20 Effectiveness Effectiveness NNP cord-325325-xw7627x9 213 21 of of IN cord-325325-xw7627x9 213 22 oseltamivir oseltamivir NNP cord-325325-xw7627x9 213 23 in in IN cord-325325-xw7627x9 213 24 preventing prevent VBG cord-325325-xw7627x9 213 25 influenza influenza NN cord-325325-xw7627x9 213 26 in in IN cord-325325-xw7627x9 213 27 household household NN cord-325325-xw7627x9 213 28 contacts contact NNS cord-325325-xw7627x9 213 29 : : : cord-325325-xw7627x9 213 30 a a DT cord-325325-xw7627x9 213 31 randomized randomized JJ cord-325325-xw7627x9 213 32 controlled control VBN cord-325325-xw7627x9 213 33 trial trial NN cord-325325-xw7627x9 213 34 Protecting protect VBG cord-325325-xw7627x9 213 35 healthcare healthcare NN cord-325325-xw7627x9 213 36 staff staff NN cord-325325-xw7627x9 213 37 from from IN cord-325325-xw7627x9 213 38 severe severe JJ cord-325325-xw7627x9 213 39 acute acute JJ cord-325325-xw7627x9 213 40 respiratory respiratory JJ cord-325325-xw7627x9 213 41 syndrome syndrome NN cord-325325-xw7627x9 213 42 : : : cord-325325-xw7627x9 213 43 filtration filtration NN cord-325325-xw7627x9 213 44 capacity capacity NN cord-325325-xw7627x9 213 45 of of IN cord-325325-xw7627x9 213 46 multiple multiple JJ cord-325325-xw7627x9 213 47 surgical surgical JJ cord-325325-xw7627x9 213 48 masks mask NNS cord-325325-xw7627x9 213 49 Preparation preparation NN cord-325325-xw7627x9 213 50 of of IN cord-325325-xw7627x9 213 51 a a DT cord-325325-xw7627x9 213 52 standardized standardized JJ cord-325325-xw7627x9 213 53 , , , cord-325325-xw7627x9 213 54 efficacious efficacious JJ cord-325325-xw7627x9 213 55 agricultural agricultural JJ cord-325325-xw7627x9 213 56 H5N3 H5N3 NNP cord-325325-xw7627x9 213 57 vaccine vaccine NN cord-325325-xw7627x9 213 58 by by IN cord-325325-xw7627x9 213 59 reverse reverse JJ cord-325325-xw7627x9 213 60 genetics genetics NN cord-325325-xw7627x9 213 61 Confronting confront VBG cord-325325-xw7627x9 213 62 the the DT cord-325325-xw7627x9 213 63 avian avian JJ cord-325325-xw7627x9 213 64 influenza influenza NN cord-325325-xw7627x9 213 65 threat threat NN cord-325325-xw7627x9 213 66 : : : cord-325325-xw7627x9 213 67 vaccine vaccine NN cord-325325-xw7627x9 213 68 development development NN cord-325325-xw7627x9 213 69 for for IN cord-325325-xw7627x9 213 70 a a DT cord-325325-xw7627x9 213 71 potential potential JJ cord-325325-xw7627x9 213 72 pandemic pandemic NN cord-325325-xw7627x9 213 73 Immunization Immunization NNP cord-325325-xw7627x9 213 74 with with IN cord-325325-xw7627x9 213 75 reverse reverse JJ cord-325325-xw7627x9 213 76 - - HYPH cord-325325-xw7627x9 213 77 genetics genetics NN cord-325325-xw7627x9 213 78 - - HYPH cord-325325-xw7627x9 213 79 produced produce VBN cord-325325-xw7627x9 213 80 H5N1 H5N1 NNP cord-325325-xw7627x9 213 81 influenza influenza NN cord-325325-xw7627x9 213 82 vaccine vaccine NN cord-325325-xw7627x9 213 83 protects protect VBZ cord-325325-xw7627x9 213 84 ferrets ferret NNS cord-325325-xw7627x9 213 85 against against IN cord-325325-xw7627x9 213 86 homologous homologous JJ cord-325325-xw7627x9 213 87 and and CC cord-325325-xw7627x9 213 88 heterologous heterologous JJ cord-325325-xw7627x9 213 89 challenge challenge NN cord-325325-xw7627x9 213 90 Safety Safety NNP cord-325325-xw7627x9 213 91 and and CC cord-325325-xw7627x9 213 92 immunogenicity immunogenicity NN cord-325325-xw7627x9 213 93 of of IN cord-325325-xw7627x9 213 94 an an DT cord-325325-xw7627x9 213 95 inactivated inactivate VBN cord-325325-xw7627x9 213 96 subvirion subvirion NN cord-325325-xw7627x9 213 97 influenza influenza NN cord-325325-xw7627x9 213 98 A a NN cord-325325-xw7627x9 213 99 ( ( -LRB- cord-325325-xw7627x9 213 100 H5N1 H5N1 NNP cord-325325-xw7627x9 213 101 ) ) -RRB- cord-325325-xw7627x9 213 102 vaccine vaccine NN cord-325325-xw7627x9 213 103 Lethal lethal JJ cord-325325-xw7627x9 213 104 avian avian JJ cord-325325-xw7627x9 213 105 influenza influenza NN cord-325325-xw7627x9 213 106 A a NN cord-325325-xw7627x9 213 107 ( ( -LRB- cord-325325-xw7627x9 213 108 H5N1 H5N1 NNP cord-325325-xw7627x9 213 109 ) ) -RRB- cord-325325-xw7627x9 213 110 infection infection NN cord-325325-xw7627x9 213 111 in in IN cord-325325-xw7627x9 213 112 a a DT cord-325325-xw7627x9 213 113 pregnant pregnant JJ cord-325325-xw7627x9 213 114 woman woman NN cord-325325-xw7627x9 213 115 in in IN cord-325325-xw7627x9 213 116 Anhui Anhui NNP cord-325325-xw7627x9 213 117 Province Province NNP cord-325325-xw7627x9 213 118 , , , cord-325325-xw7627x9 213 119 China China NNP cord-325325-xw7627x9 213 120 Vaccines Vaccines NNPS cord-325325-xw7627x9 213 121 against against IN cord-325325-xw7627x9 213 122 avian avian JJ cord-325325-xw7627x9 213 123 influenza influenza NN cord-325325-xw7627x9 213 124 -- -- : cord-325325-xw7627x9 213 125 a a DT cord-325325-xw7627x9 213 126 race race NN cord-325325-xw7627x9 213 127 against against IN cord-325325-xw7627x9 213 128 time time NN cord-325325-xw7627x9 213 129 Immunogenicity Immunogenicity NNP cord-325325-xw7627x9 213 130 of of IN cord-325325-xw7627x9 213 131 a a DT cord-325325-xw7627x9 213 132 monovalent monovalent NN cord-325325-xw7627x9 213 133 , , , cord-325325-xw7627x9 213 134 aluminum aluminum NN cord-325325-xw7627x9 213 135 - - HYPH cord-325325-xw7627x9 213 136 adjuvanted adjuvante VBN cord-325325-xw7627x9 213 137 influenza influenza NN cord-325325-xw7627x9 213 138 whole whole JJ cord-325325-xw7627x9 213 139 virus virus NN cord-325325-xw7627x9 213 140 vaccine vaccine NN cord-325325-xw7627x9 213 141 for for IN cord-325325-xw7627x9 213 142 pandemic pandemic NN cord-325325-xw7627x9 213 143 use use NN cord-325325-xw7627x9 213 144 Pandemic Pandemic NNP cord-325325-xw7627x9 213 145 preparedness preparedness NN cord-325325-xw7627x9 213 146 : : : cord-325325-xw7627x9 213 147 lessons lesson NNS cord-325325-xw7627x9 213 148 learnt learn VBN cord-325325-xw7627x9 213 149 from from IN cord-325325-xw7627x9 213 150 H2N2 H2N2 NNP cord-325325-xw7627x9 213 151 and and CC cord-325325-xw7627x9 213 152 H9N2 H9N2 NNP cord-325325-xw7627x9 213 153 candidate candidate NN cord-325325-xw7627x9 213 154 vaccines vaccine NNS cord-325325-xw7627x9 213 155 Safety safety NN cord-325325-xw7627x9 213 156 and and CC cord-325325-xw7627x9 213 157 immunogenicity immunogenicity NN cord-325325-xw7627x9 213 158 of of IN cord-325325-xw7627x9 213 159 an an DT cord-325325-xw7627x9 213 160 inactivated inactivated JJ cord-325325-xw7627x9 213 161 split split NN cord-325325-xw7627x9 213 162 - - HYPH cord-325325-xw7627x9 213 163 virion virion NN cord-325325-xw7627x9 213 164 influenza influenza NN cord-325325-xw7627x9 213 165 A a NN cord-325325-xw7627x9 213 166 / / SYM cord-325325-xw7627x9 213 167 Vietnam/1194/2004 Vietnam/1194/2004 NNP cord-325325-xw7627x9 213 168 ( ( -LRB- cord-325325-xw7627x9 213 169 H5N1 H5N1 NNP cord-325325-xw7627x9 213 170 ) ) -RRB- cord-325325-xw7627x9 213 171 vaccine vaccine NN cord-325325-xw7627x9 213 172 : : : cord-325325-xw7627x9 213 173 phase phase NN cord-325325-xw7627x9 213 174 I -PRON- PRP cord-325325-xw7627x9 213 175 randomized randomize VBD cord-325325-xw7627x9 213 176 trial trial NN cord-325325-xw7627x9 213 177 Development Development NNP cord-325325-xw7627x9 213 178 of of IN cord-325325-xw7627x9 213 179 adenoviral adenoviral JJ cord-325325-xw7627x9 213 180 - - HYPH cord-325325-xw7627x9 213 181 vector vector NN cord-325325-xw7627x9 213 182 - - HYPH cord-325325-xw7627x9 213 183 based base VBN cord-325325-xw7627x9 213 184 pandemic pandemic NN cord-325325-xw7627x9 213 185 influenza influenza NN cord-325325-xw7627x9 213 186 vaccine vaccine NN cord-325325-xw7627x9 213 187 against against IN cord-325325-xw7627x9 213 188 antigenically antigenically RB cord-325325-xw7627x9 213 189 distinct distinct JJ cord-325325-xw7627x9 213 190 human human NN cord-325325-xw7627x9 213 191 H5N1 H5N1 NNP cord-325325-xw7627x9 213 192 strains strain NNS cord-325325-xw7627x9 213 193 in in IN cord-325325-xw7627x9 213 194 mice mouse NNS cord-325325-xw7627x9 213 195 From from IN cord-325325-xw7627x9 213 196 lethal lethal JJ cord-325325-xw7627x9 213 197 virus virus NN cord-325325-xw7627x9 213 198 to to IN cord-325325-xw7627x9 213 199 life life NN cord-325325-xw7627x9 213 200 - - HYPH cord-325325-xw7627x9 213 201 saving save VBG cord-325325-xw7627x9 213 202 vaccine vaccine NN cord-325325-xw7627x9 213 203 : : : cord-325325-xw7627x9 213 204 developing develop VBG cord-325325-xw7627x9 213 205 inactivated inactivate VBN cord-325325-xw7627x9 213 206 vaccines vaccine NNS cord-325325-xw7627x9 213 207 for for IN cord-325325-xw7627x9 213 208 pandemic pandemic NN cord-325325-xw7627x9 213 209 influenza influenza NN cord-325325-xw7627x9 213 210 FDA FDA NNP cord-325325-xw7627x9 213 211 approves approve VBZ cord-325325-xw7627x9 213 212 first first JJ cord-325325-xw7627x9 213 213 U.S. U.S. NNP cord-325325-xw7627x9 213 214 vaccine vaccine NN cord-325325-xw7627x9 213 215 for for IN cord-325325-xw7627x9 213 216 humans human NNS cord-325325-xw7627x9 213 217 against against IN cord-325325-xw7627x9 213 218 the the DT cord-325325-xw7627x9 213 219 avian avian JJ cord-325325-xw7627x9 213 220 influenza influenza NN cord-325325-xw7627x9 213 221 virus virus NN cord-325325-xw7627x9 213 222 H5N1 H5N1 NNP cord-325325-xw7627x9 213 223 A a DT cord-325325-xw7627x9 213 224 potential potential JJ cord-325325-xw7627x9 213 225 influenza influenza NN cord-325325-xw7627x9 213 226 pandemic pandemic NN cord-325325-xw7627x9 213 227 : : : cord-325325-xw7627x9 213 228 an an DT cord-325325-xw7627x9 213 229 update update NN cord-325325-xw7627x9 213 230 on on IN cord-325325-xw7627x9 213 231 possible possible JJ cord-325325-xw7627x9 213 232 macroeconomic macroeconomic JJ cord-325325-xw7627x9 213 233 effects effect NNS cord-325325-xw7627x9 213 234 and and CC cord-325325-xw7627x9 213 235 policy policy NN cord-325325-xw7627x9 213 236 issues issue NNS