id	sid	tid	token	lemma	pos
cord-326960-9phlylce	1	1	key	key	JJ
cord-326960-9phlylce	1	2	:	:	:
cord-326960-9phlylce	1	3	cord-326960	cord-326960	NNP
cord-326960-9phlylce	1	4	-	-	HYPH
cord-326960-9phlylce	1	5	9phlylce	9phlylce	CD
cord-326960-9phlylce	1	6	authors	author	NNS
cord-326960-9phlylce	1	7	:	:	:
cord-326960-9phlylce	1	8	Felberbaum	Felberbaum	NNP
cord-326960-9phlylce	1	9	,	,	,
cord-326960-9phlylce	1	10	Rachael	Rachael	NNP
cord-326960-9phlylce	1	11	S.	S.	NNP
cord-326960-9phlylce	1	12	title	title	NN
cord-326960-9phlylce	1	13	:	:	:
cord-326960-9phlylce	1	14	The	the	DT
cord-326960-9phlylce	1	15	baculovirus	baculovirus	NNP
cord-326960-9phlylce	1	16	expression	expression	NN
cord-326960-9phlylce	1	17	vector	vector	NN
cord-326960-9phlylce	1	18	system	system	NN
cord-326960-9phlylce	1	19	:	:	:
cord-326960-9phlylce	1	20	A	a	DT
cord-326960-9phlylce	1	21	commercial	commercial	JJ
cord-326960-9phlylce	1	22	manufacturing	manufacturing	NN
cord-326960-9phlylce	1	23	platform	platform	NN
cord-326960-9phlylce	1	24	for	for	IN
cord-326960-9phlylce	1	25	viral	viral	JJ
cord-326960-9phlylce	1	26	vaccines	vaccine	NNS
cord-326960-9phlylce	1	27	and	and	CC
cord-326960-9phlylce	1	28	gene	gene	NN
cord-326960-9phlylce	1	29	therapy	therapy	NN
cord-326960-9phlylce	1	30	vectors	vector	NNS
cord-326960-9phlylce	1	31	date	date	NN
cord-326960-9phlylce	1	32	:	:	:
cord-326960-9phlylce	1	33	2015	2015	CD
cord-326960-9phlylce	1	34	-	-	HYPH
cord-326960-9phlylce	1	35	03	03	CD
cord-326960-9phlylce	1	36	-	-	HYPH
cord-326960-9phlylce	1	37	20	20	CD
cord-326960-9phlylce	1	38	journal	journal	NN
cord-326960-9phlylce	1	39	:	:	:
cord-326960-9phlylce	2	1	Biotechnol	Biotechnol	NNP
cord-326960-9phlylce	2	2	J	J	NNP
cord-326960-9phlylce	2	3	DOI	DOI	NNP
cord-326960-9phlylce	2	4	:	:	:
cord-326960-9phlylce	3	1	10.1002	10.1002	CD
cord-326960-9phlylce	3	2	/	/	SYM
cord-326960-9phlylce	3	3	biot.201400438	biot.201400438	NNP
cord-326960-9phlylce	3	4	sha	sha	NNP
cord-326960-9phlylce	3	5	:	:	:
cord-326960-9phlylce	4	1	5715f607a90d87b6659d0a848315b705b42f9b3e	5715f607a90d87b6659d0a848315b705b42f9b3e	CD
cord-326960-9phlylce	4	2	doc_id	doc_id	CD
cord-326960-9phlylce	4	3	:	:	:
cord-326960-9phlylce	4	4	326960	326960	CD
cord-326960-9phlylce	4	5	cord_uid	cord_uid	NNS
cord-326960-9phlylce	4	6	:	:	:
cord-326960-9phlylce	5	1	9phlylce	9phlylce	LS
cord-326960-9phlylce	6	1	The	the	DT
cord-326960-9phlylce	6	2	baculovirus	baculovirus	NNP
cord-326960-9phlylce	6	3	expression	expression	NN
cord-326960-9phlylce	6	4	vector	vector	NN
cord-326960-9phlylce	6	5	system	system	NN
cord-326960-9phlylce	6	6	(	(	-LRB-
cord-326960-9phlylce	6	7	BEVS	BEVS	NNP
cord-326960-9phlylce	6	8	)	)	-RRB-
cord-326960-9phlylce	6	9	platform	platform	NN
cord-326960-9phlylce	6	10	has	have	VBZ
cord-326960-9phlylce	6	11	become	become	VBN
cord-326960-9phlylce	6	12	an	an	DT
cord-326960-9phlylce	6	13	established	established	JJ
cord-326960-9phlylce	6	14	manufacturing	manufacturing	NN
cord-326960-9phlylce	6	15	platform	platform	NN
cord-326960-9phlylce	6	16	for	for	IN
cord-326960-9phlylce	6	17	the	the	DT
cord-326960-9phlylce	6	18	production	production	NN
cord-326960-9phlylce	6	19	of	of	IN
cord-326960-9phlylce	6	20	viral	viral	JJ
cord-326960-9phlylce	6	21	vaccines	vaccine	NNS
cord-326960-9phlylce	6	22	and	and	CC
cord-326960-9phlylce	6	23	gene	gene	NN
cord-326960-9phlylce	6	24	therapy	therapy	NN
cord-326960-9phlylce	6	25	vectors	vector	NNS
cord-326960-9phlylce	6	26	.	.	.
cord-326960-9phlylce	7	1	Nine	Nine	NNP
cord-326960-9phlylce	7	2	BEVS‐derived	BEVS‐derived	NNP
cord-326960-9phlylce	7	3	products	product	NNS
cord-326960-9phlylce	7	4	have	have	VBP
cord-326960-9phlylce	7	5	been	be	VBN
cord-326960-9phlylce	7	6	approved	approve	VBN
cord-326960-9phlylce	7	7	–	–	:
cord-326960-9phlylce	7	8	four	four	CD
cord-326960-9phlylce	7	9	for	for	IN
cord-326960-9phlylce	7	10	human	human	JJ
cord-326960-9phlylce	7	11	use	use	NN
cord-326960-9phlylce	8	1	(	(	-LRB-
cord-326960-9phlylce	8	2	Cervarix	Cervarix	NNP
cord-326960-9phlylce	8	3	®	®	ADD
cord-326960-9phlylce	8	4	,	,	,
cord-326960-9phlylce	8	5	Provenge	Provenge	NNP
cord-326960-9phlylce	8	6	®	®	VBP
cord-326960-9phlylce	8	7	,	,	,
cord-326960-9phlylce	8	8	Glybera	Glybera	NNP
cord-326960-9phlylce	8	9	®	®	VBP
cord-326960-9phlylce	8	10	and	and	CC
cord-326960-9phlylce	8	11	Flublok	Flublok	NNP
cord-326960-9phlylce	8	12	®	®	NNP
cord-326960-9phlylce	8	13	)	)	-RRB-
cord-326960-9phlylce	8	14	and	and	CC
cord-326960-9phlylce	8	15	five	five	CD
cord-326960-9phlylce	8	16	for	for	IN
cord-326960-9phlylce	8	17	veterinary	veterinary	JJ
cord-326960-9phlylce	8	18	use	use	NN
cord-326960-9phlylce	8	19	(	(	-LRB-
cord-326960-9phlylce	8	20	Porcilis	Porcilis	NNP
cord-326960-9phlylce	8	21	®	®	POS
cord-326960-9phlylce	8	22	Pesti	Pesti	NNP
cord-326960-9phlylce	8	23	,	,	,
cord-326960-9phlylce	8	24	BAYOVAC	BAYOVAC	NNP
cord-326960-9phlylce	8	25	CSF	CSF	NNP
cord-326960-9phlylce	8	26	E2	E2	NNP
cord-326960-9phlylce	8	27	®	®	NNP
cord-326960-9phlylce	8	28	,	,	,
cord-326960-9phlylce	8	29	Circumvent	circumvent	VB
cord-326960-9phlylce	9	1	®	®	,
cord-326960-9phlylce	9	2	PCV	PCV	NNP
cord-326960-9phlylce	9	3	,	,	,
cord-326960-9phlylce	10	1	Ingelvac	Ingelvac	NNP
cord-326960-9phlylce	10	2	CircoFLEX	CircoFLEX	NNP
cord-326960-9phlylce	10	3	®	®	.
cord-326960-9phlylce	10	4	and	and	CC
cord-326960-9phlylce	11	1	Porcilis	Porcilis	NNP
cord-326960-9phlylce	11	2	®	®	POS
cord-326960-9phlylce	11	3	PCV	PCV	NNP
cord-326960-9phlylce	11	4	)	)	-RRB-
cord-326960-9phlylce	11	5	.	.	.
cord-326960-9phlylce	12	1	The	the	DT
cord-326960-9phlylce	12	2	BEVS	BEVS	NNP
cord-326960-9phlylce	12	3	platform	platform	NN
cord-326960-9phlylce	12	4	offers	offer	VBZ
cord-326960-9phlylce	12	5	many	many	JJ
cord-326960-9phlylce	12	6	advantages	advantage	NNS
cord-326960-9phlylce	12	7	,	,	,
cord-326960-9phlylce	12	8	including	include	VBG
cord-326960-9phlylce	12	9	manufacturing	manufacture	VBG
cord-326960-9phlylce	12	10	speed	speed	NN
cord-326960-9phlylce	12	11	,	,	,
cord-326960-9phlylce	12	12	flexible	flexible	JJ
cord-326960-9phlylce	12	13	product	product	NN
cord-326960-9phlylce	12	14	design	design	NN
cord-326960-9phlylce	12	15	,	,	,
cord-326960-9phlylce	12	16	inherent	inherent	JJ
cord-326960-9phlylce	12	17	safety	safety	NN
cord-326960-9phlylce	12	18	and	and	CC
cord-326960-9phlylce	12	19	scalability	scalability	NN
cord-326960-9phlylce	12	20	.	.	.
cord-326960-9phlylce	13	1	This	this	DT
cord-326960-9phlylce	13	2	combination	combination	NN
cord-326960-9phlylce	13	3	of	of	IN
cord-326960-9phlylce	13	4	features	feature	NNS
cord-326960-9phlylce	13	5	and	and	CC
cord-326960-9phlylce	13	6	product	product	NN
cord-326960-9phlylce	13	7	approvals	approval	NNS
cord-326960-9phlylce	13	8	has	have	VBZ
cord-326960-9phlylce	13	9	previously	previously	RB
cord-326960-9phlylce	13	10	attracted	attract	VBN
cord-326960-9phlylce	13	11	interest	interest	NN
cord-326960-9phlylce	13	12	from	from	IN
cord-326960-9phlylce	13	13	academic	academic	JJ
cord-326960-9phlylce	13	14	researchers	researcher	NNS
cord-326960-9phlylce	13	15	,	,	,
cord-326960-9phlylce	13	16	and	and	CC
cord-326960-9phlylce	13	17	more	more	RBR
cord-326960-9phlylce	13	18	recently	recently	RB
cord-326960-9phlylce	13	19	from	from	IN
cord-326960-9phlylce	13	20	industry	industry	NN
cord-326960-9phlylce	13	21	leaders	leader	NNS
cord-326960-9phlylce	13	22	,	,	,
cord-326960-9phlylce	13	23	to	to	TO
cord-326960-9phlylce	13	24	utilize	utilize	VB
cord-326960-9phlylce	13	25	BEVS	BEVS	NNP
cord-326960-9phlylce	13	26	to	to	TO
cord-326960-9phlylce	13	27	develop	develop	VB
cord-326960-9phlylce	13	28	next	next	JJ
cord-326960-9phlylce	13	29	generation	generation	NN
cord-326960-9phlylce	13	30	vaccines	vaccine	NNS
cord-326960-9phlylce	13	31	,	,	,
cord-326960-9phlylce	13	32	vectors	vector	NNS
cord-326960-9phlylce	13	33	for	for	IN
cord-326960-9phlylce	13	34	gene	gene	NN
cord-326960-9phlylce	13	35	therapy	therapy	NN
cord-326960-9phlylce	13	36	,	,	,
cord-326960-9phlylce	13	37	and	and	CC
cord-326960-9phlylce	13	38	other	other	JJ
cord-326960-9phlylce	13	39	biopharmaceutical	biopharmaceutical	JJ
cord-326960-9phlylce	13	40	complex	complex	JJ
cord-326960-9phlylce	13	41	proteins	protein	NNS
cord-326960-9phlylce	13	42	.	.	.
cord-326960-9phlylce	14	1	In	in	IN
cord-326960-9phlylce	14	2	this	this	DT
cord-326960-9phlylce	14	3	review	review	NN
cord-326960-9phlylce	14	4	,	,	,
cord-326960-9phlylce	14	5	we	-PRON-	PRP
cord-326960-9phlylce	14	6	explore	explore	VBP
cord-326960-9phlylce	14	7	the	the	DT
cord-326960-9phlylce	14	8	BEVS	BEVS	NNP
cord-326960-9phlylce	14	9	platform	platform	NN
cord-326960-9phlylce	14	10	,	,	,
cord-326960-9phlylce	14	11	detailing	detail	VBG
cord-326960-9phlylce	14	12	how	how	WRB
cord-326960-9phlylce	14	13	it	-PRON-	PRP
cord-326960-9phlylce	14	14	works	work	VBZ
cord-326960-9phlylce	14	15	,	,	,
cord-326960-9phlylce	14	16	platform	platform	NN
cord-326960-9phlylce	14	17	features	feature	NNS
cord-326960-9phlylce	14	18	and	and	CC
cord-326960-9phlylce	14	19	limitations	limitation	NNS
cord-326960-9phlylce	14	20	and	and	CC
cord-326960-9phlylce	14	21	important	important	JJ
cord-326960-9phlylce	14	22	considerations	consideration	NNS
cord-326960-9phlylce	14	23	for	for	IN
cord-326960-9phlylce	14	24	manufacturing	manufacturing	NN
cord-326960-9phlylce	14	25	and	and	CC
cord-326960-9phlylce	14	26	regulatory	regulatory	JJ
cord-326960-9phlylce	14	27	approval	approval	NN
cord-326960-9phlylce	14	28	.	.	.
cord-326960-9phlylce	15	1	To	to	TO
cord-326960-9phlylce	15	2	underscore	underscore	VB
cord-326960-9phlylce	15	3	the	the	DT
cord-326960-9phlylce	15	4	growth	growth	NN
cord-326960-9phlylce	15	5	in	in	IN
cord-326960-9phlylce	15	6	opportunities	opportunity	NNS
cord-326960-9phlylce	15	7	for	for	IN
cord-326960-9phlylce	15	8	BEVS‐derived	BEVS‐derived	NNP
cord-326960-9phlylce	15	9	products	product	NNS
cord-326960-9phlylce	15	10	,	,	,
cord-326960-9phlylce	15	11	we	-PRON-	PRP
cord-326960-9phlylce	15	12	discuss	discuss	VBP
cord-326960-9phlylce	15	13	the	the	DT
cord-326960-9phlylce	15	14	latest	late	JJS
cord-326960-9phlylce	15	15	product	product	NN
cord-326960-9phlylce	15	16	developments	development	NNS
cord-326960-9phlylce	15	17	in	in	IN
cord-326960-9phlylce	15	18	the	the	DT
cord-326960-9phlylce	15	19	gene	gene	NN
cord-326960-9phlylce	15	20	therapy	therapy	NN
cord-326960-9phlylce	15	21	and	and	CC
cord-326960-9phlylce	15	22	influenza	influenza	NN
cord-326960-9phlylce	15	23	vaccine	vaccine	NN
cord-326960-9phlylce	15	24	fields	field	NNS
cord-326960-9phlylce	15	25	that	that	WDT
cord-326960-9phlylce	15	26	follow	follow	VBP
cord-326960-9phlylce	15	27	in	in	IN
cord-326960-9phlylce	15	28	the	the	DT
cord-326960-9phlylce	15	29	wake	wake	NN
cord-326960-9phlylce	15	30	of	of	IN
cord-326960-9phlylce	15	31	the	the	DT
cord-326960-9phlylce	15	32	recent	recent	JJ
cord-326960-9phlylce	15	33	product	product	NN
cord-326960-9phlylce	15	34	approvals	approval	NNS
cord-326960-9phlylce	15	35	of	of	IN
cord-326960-9phlylce	15	36	Glybera	Glybera	NNP
cord-326960-9phlylce	15	37	®	®	VBP
cord-326960-9phlylce	15	38	and	and	CC
cord-326960-9phlylce	15	39	Flublok	Flublok	NNP
cord-326960-9phlylce	15	40	®	®	NNP
cord-326960-9phlylce	15	41	,	,	,
cord-326960-9phlylce	15	42	respectively	respectively	RB
cord-326960-9phlylce	15	43	.	.	.
cord-326960-9phlylce	16	1	We	-PRON-	PRP
cord-326960-9phlylce	16	2	anticipate	anticipate	VBP
cord-326960-9phlylce	16	3	that	that	IN
cord-326960-9phlylce	16	4	the	the	DT
cord-326960-9phlylce	16	5	utility	utility	NN
cord-326960-9phlylce	16	6	of	of	IN
cord-326960-9phlylce	16	7	the	the	DT
cord-326960-9phlylce	16	8	platform	platform	NN
cord-326960-9phlylce	16	9	will	will	MD
cord-326960-9phlylce	16	10	expand	expand	VB
cord-326960-9phlylce	16	11	even	even	RB
cord-326960-9phlylce	16	12	further	far	RBR
cord-326960-9phlylce	16	13	as	as	IN
cord-326960-9phlylce	16	14	new	new	JJ
cord-326960-9phlylce	16	15	BEVS‐derived	BEVS‐derived	NNP
cord-326960-9phlylce	16	16	products	product	NNS
cord-326960-9phlylce	16	17	attain	attain	VBP
cord-326960-9phlylce	16	18	licensure	licensure	NN
cord-326960-9phlylce	16	19	.	.	.
cord-326960-9phlylce	17	1	Finally	finally	RB
cord-326960-9phlylce	17	2	,	,	,
cord-326960-9phlylce	17	3	we	-PRON-	PRP
cord-326960-9phlylce	17	4	touch	touch	VBP
cord-326960-9phlylce	17	5	on	on	IN
cord-326960-9phlylce	17	6	some	some	DT
cord-326960-9phlylce	17	7	of	of	IN
cord-326960-9phlylce	17	8	the	the	DT
cord-326960-9phlylce	17	9	areas	area	NNS
cord-326960-9phlylce	17	10	where	where	WRB
cord-326960-9phlylce	17	11	new	new	JJ
cord-326960-9phlylce	17	12	BEVS‐derived	BEVS‐derived	NNP
cord-326960-9phlylce	17	13	products	product	NNS
cord-326960-9phlylce	17	14	are	be	VBP
cord-326960-9phlylce	17	15	likely	likely	JJ
cord-326960-9phlylce	17	16	to	to	TO
cord-326960-9phlylce	17	17	emerge	emerge	VB
cord-326960-9phlylce	17	18	.	.	.
cord-326960-9phlylce	18	1	The	the	DT
cord-326960-9phlylce	18	2	baculovirus	baculovirus	NNP
cord-326960-9phlylce	18	3	expression	expression	NN
cord-326960-9phlylce	18	4	vector	vector	NN
cord-326960-9phlylce	18	5	system	system	NN
cord-326960-9phlylce	18	6	(	(	-LRB-
cord-326960-9phlylce	18	7	BEVS	BEVS	NNP
cord-326960-9phlylce	18	8	)	)	-RRB-
cord-326960-9phlylce	18	9	is	be	VBZ
cord-326960-9phlylce	18	10	far	far	RB
cord-326960-9phlylce	18	11	from	from	IN
cord-326960-9phlylce	18	12	new	new	JJ
cord-326960-9phlylce	18	13	.	.	.
cord-326960-9phlylce	19	1	For	for	IN
cord-326960-9phlylce	19	2	thirty	thirty	CD
cord-326960-9phlylce	19	3	years	year	NNS
cord-326960-9phlylce	19	4	researchers	researcher	NNS
cord-326960-9phlylce	19	5	have	have	VBP
cord-326960-9phlylce	19	6	been	be	VBN
cord-326960-9phlylce	19	7	using	use	VBG
cord-326960-9phlylce	19	8	this	this	DT
cord-326960-9phlylce	19	9	platform	platform	NN
cord-326960-9phlylce	19	10	to	to	TO
cord-326960-9phlylce	19	11	express	express	VB
cord-326960-9phlylce	19	12	recombinant	recombinant	JJ
cord-326960-9phlylce	19	13	proteins	protein	NNS
cord-326960-9phlylce	19	14	,	,	,
cord-326960-9phlylce	19	15	and	and	CC
cord-326960-9phlylce	19	16	thousands	thousand	NNS
cord-326960-9phlylce	19	17	of	of	IN
cord-326960-9phlylce	19	18	proteins	protein	NNS
cord-326960-9phlylce	19	19	have	have	VBP
cord-326960-9phlylce	19	20	been	be	VBN
cord-326960-9phlylce	19	21	successfully	successfully	RB
cord-326960-9phlylce	19	22	expressed	express	VBN
cord-326960-9phlylce	19	23	and	and	CC
cord-326960-9phlylce	19	24	purified	purify	VBN
cord-326960-9phlylce	19	25	.	.	.
cord-326960-9phlylce	20	1	However	however	RB
cord-326960-9phlylce	20	2	,	,	,
cord-326960-9phlylce	20	3	for	for	IN
cord-326960-9phlylce	20	4	much	much	JJ
cord-326960-9phlylce	20	5	of	of	IN
cord-326960-9phlylce	20	6	this	this	DT
cord-326960-9phlylce	20	7	time	time	NN
cord-326960-9phlylce	20	8	,	,	,
cord-326960-9phlylce	20	9	BEVS	BEVS	NNP
cord-326960-9phlylce	20	10	was	be	VBD
cord-326960-9phlylce	20	11	rele	rele	RB
cord-326960-9phlylce	20	12	-	-	HYPH
cord-326960-9phlylce	20	13	gated	gate	VBN
cord-326960-9phlylce	20	14	to	to	IN
cord-326960-9phlylce	20	15	the	the	DT
cord-326960-9phlylce	20	16	ranks	rank	NNS
cord-326960-9phlylce	20	17	of	of	IN
cord-326960-9phlylce	20	18	research	research	NN
cord-326960-9phlylce	20	19	tool	tool	NN
cord-326960-9phlylce	20	20	.	.	.
cord-326960-9phlylce	21	1	What	what	WP
cord-326960-9phlylce	21	2	we	-PRON-	PRP
cord-326960-9phlylce	21	3	have	have	VBP
cord-326960-9phlylce	21	4	seen	see	VBN
cord-326960-9phlylce	21	5	in	in	IN
cord-326960-9phlylce	21	6	the	the	DT
cord-326960-9phlylce	21	7	last	last	JJ
cord-326960-9phlylce	21	8	decade	decade	NN
cord-326960-9phlylce	21	9	is	be	VBZ
cord-326960-9phlylce	21	10	the	the	DT
cord-326960-9phlylce	21	11	elevation	elevation	NN
cord-326960-9phlylce	21	12	of	of	IN
cord-326960-9phlylce	21	13	BEVS	BEVS	NNP
cord-326960-9phlylce	21	14	from	from	IN
cord-326960-9phlylce	21	15	research	research	NN
cord-326960-9phlylce	21	16	tool	tool	NN
cord-326960-9phlylce	21	17	to	to	IN
cord-326960-9phlylce	21	18	an	an	DT
cord-326960-9phlylce	21	19	established	establish	VBN
cord-326960-9phlylce	21	20	manufacturing	manufacturing	NN
cord-326960-9phlylce	21	21	platform	platform	NN
cord-326960-9phlylce	21	22	for	for	IN
cord-326960-9phlylce	21	23	production	production	NN
cord-326960-9phlylce	21	24	of	of	IN
cord-326960-9phlylce	21	25	novel	novel	JJ
cord-326960-9phlylce	21	26	biologic	biologic	JJ
cord-326960-9phlylce	21	27	products	product	NNS
cord-326960-9phlylce	21	28	.	.	.
cord-326960-9phlylce	22	1	Ten	ten	CD
cord-326960-9phlylce	22	2	years	year	NNS
cord-326960-9phlylce	22	3	ago	ago	RB
cord-326960-9phlylce	22	4	there	there	EX
cord-326960-9phlylce	22	5	were	be	VBD
cord-326960-9phlylce	22	6	only	only	RB
cord-326960-9phlylce	22	7	two	two	CD
cord-326960-9phlylce	22	8	commercial	commercial	JJ
cord-326960-9phlylce	22	9	products	product	NNS
cord-326960-9phlylce	22	10	manufactured	manufacture	VBN
cord-326960-9phlylce	22	11	using	use	VBG
cord-326960-9phlylce	22	12	the	the	DT
cord-326960-9phlylce	22	13	BEVS	BEVS	NNP
cord-326960-9phlylce	22	14	manufacturing	manufacture	VBG
cord-326960-9phlylce	22	15	platform	platform	NN
cord-326960-9phlylce	22	16	and	and	CC
cord-326960-9phlylce	22	17	both	both	DT
cord-326960-9phlylce	22	18	of	of	IN
cord-326960-9phlylce	22	19	these	these	DT
cord-326960-9phlylce	22	20	were	be	VBD
cord-326960-9phlylce	22	21	veterinary	veterinary	JJ
cord-326960-9phlylce	22	22	vaccines	vaccine	NNS
cord-326960-9phlylce	22	23	to	to	TO
cord-326960-9phlylce	22	24	prevent	prevent	VB
cord-326960-9phlylce	22	25	classical	classical	JJ
cord-326960-9phlylce	22	26	swine	swine	NN
cord-326960-9phlylce	22	27	fever	fever	NN
cord-326960-9phlylce	22	28	in	in	IN
cord-326960-9phlylce	22	29	pigs	pig	NNS
cord-326960-9phlylce	22	30	.	.	.
cord-326960-9phlylce	23	1	Since	since	IN
cord-326960-9phlylce	23	2	then	then	RB
cord-326960-9phlylce	23	3	,	,	,
cord-326960-9phlylce	23	4	seven	seven	CD
cord-326960-9phlylce	23	5	new	new	JJ
cord-326960-9phlylce	23	6	products	product	NNS
cord-326960-9phlylce	23	7	have	have	VBP
cord-326960-9phlylce	23	8	been	be	VBN
cord-326960-9phlylce	23	9	licensed	license	VBN
cord-326960-9phlylce	23	10	,	,	,
cord-326960-9phlylce	23	11	four	four	CD
cord-326960-9phlylce	23	12	of	of	IN
cord-326960-9phlylce	23	13	which	which	WDT
cord-326960-9phlylce	23	14	are	be	VBP
cord-326960-9phlylce	23	15	for	for	IN
cord-326960-9phlylce	23	16	humans	human	NNS
cord-326960-9phlylce	23	17	,	,	,
cord-326960-9phlylce	23	18	including	include	VBG
cord-326960-9phlylce	23	19	vaccines	vaccine	NNS
cord-326960-9phlylce	23	20	and	and	CC
cord-326960-9phlylce	23	21	therapeutics	therapeutic	NNS
cord-326960-9phlylce	23	22	,	,	,
cord-326960-9phlylce	23	23	and	and	CC
cord-326960-9phlylce	23	24	many	many	JJ
cord-326960-9phlylce	23	25	more	more	JJR
cord-326960-9phlylce	23	26	products	product	NNS
cord-326960-9phlylce	23	27	are	be	VBP
cord-326960-9phlylce	23	28	in	in	IN
cord-326960-9phlylce	23	29	development	development	NN
cord-326960-9phlylce	23	30	(	(	-LRB-
cord-326960-9phlylce	23	31	Table	table	NN
cord-326960-9phlylce	23	32	1	1	CD
cord-326960-9phlylce	23	33	)	)	-RRB-
cord-326960-9phlylce	23	34	[	[	-LRB-
cord-326960-9phlylce	23	35	1	1	CD
cord-326960-9phlylce	23	36	,	,	,
cord-326960-9phlylce	23	37	2	2	CD
cord-326960-9phlylce	23	38	]	]	-RRB-
cord-326960-9phlylce	23	39	.	.	.
cord-326960-9phlylce	24	1	We	-PRON-	PRP
cord-326960-9phlylce	24	2	have	have	VBP
cord-326960-9phlylce	24	3	passed	pass	VBN
cord-326960-9phlylce	24	4	a	a	DT
cord-326960-9phlylce	24	5	tipping	tipping	NN
cord-326960-9phlylce	24	6	point	point	NN
cord-326960-9phlylce	24	7	where	where	WRB
cord-326960-9phlylce	24	8	BEVS	bevs	NN
cord-326960-9phlylce	24	9	-	-	HYPH
cord-326960-9phlylce	24	10	derived	derive	VBN
cord-326960-9phlylce	24	11	products	product	NNS
cord-326960-9phlylce	24	12	are	be	VBP
cord-326960-9phlylce	24	13	becoming	become	VBG
cord-326960-9phlylce	24	14	mainstream	mainstream	NN
cord-326960-9phlylce	24	15	,	,	,
cord-326960-9phlylce	24	16	and	and	CC
cord-326960-9phlylce	24	17	the	the	DT
cord-326960-9phlylce	24	18	BEVS	BEVS	NNP
cord-326960-9phlylce	24	19	platform	platform	NN
cord-326960-9phlylce	24	20	is	be	VBZ
cord-326960-9phlylce	24	21	being	be	VBG
cord-326960-9phlylce	24	22	actively	actively	RB
cord-326960-9phlylce	24	23	utilized	utilize	VBN
cord-326960-9phlylce	24	24	by	by	IN
cord-326960-9phlylce	24	25	major	major	JJ
cord-326960-9phlylce	24	26	players	player	NNS
cord-326960-9phlylce	24	27	in	in	IN
cord-326960-9phlylce	24	28	the	the	DT
cord-326960-9phlylce	24	29	biotechnology	biotechnology	NN
cord-326960-9phlylce	24	30	industry	industry	NN
cord-326960-9phlylce	24	31	to	to	TO
cord-326960-9phlylce	24	32	develop	develop	VB
cord-326960-9phlylce	24	33	new	new	JJ
cord-326960-9phlylce	24	34	products	product	NNS
cord-326960-9phlylce	24	35	.	.	.
cord-326960-9phlylce	25	1	Although	although	IN
cord-326960-9phlylce	25	2	the	the	DT
cord-326960-9phlylce	25	3	BEVS	BEVS	NNP
cord-326960-9phlylce	25	4	platform	platform	NN
cord-326960-9phlylce	25	5	has	have	VBZ
cord-326960-9phlylce	25	6	distinct	distinct	JJ
cord-326960-9phlylce	25	7	features	feature	NNS
cord-326960-9phlylce	25	8	that	that	WDT
cord-326960-9phlylce	25	9	make	make	VBP
cord-326960-9phlylce	25	10	it	-PRON-	PRP
cord-326960-9phlylce	25	11	an	an	DT
cord-326960-9phlylce	25	12	attractive	attractive	JJ
cord-326960-9phlylce	25	13	platform	platform	NN
cord-326960-9phlylce	25	14	for	for	IN
cord-326960-9phlylce	25	15	the	the	DT
cord-326960-9phlylce	25	16	production	production	NN
cord-326960-9phlylce	25	17	of	of	IN
cord-326960-9phlylce	25	18	many	many	JJ
cord-326960-9phlylce	25	19	biologics	biologic	NNS
cord-326960-9phlylce	25	20	,	,	,
cord-326960-9phlylce	25	21	it	-PRON-	PRP
cord-326960-9phlylce	25	22	is	be	VBZ
cord-326960-9phlylce	25	23	not	not	RB
cord-326960-9phlylce	25	24	ideally	ideally	RB
cord-326960-9phlylce	25	25	suited	suit	VBN
cord-326960-9phlylce	25	26	for	for	IN
cord-326960-9phlylce	25	27	all	all	DT
cord-326960-9phlylce	25	28	products	product	NNS
cord-326960-9phlylce	25	29	.	.	.
cord-326960-9phlylce	26	1	Factors	factor	NNS
cord-326960-9phlylce	26	2	such	such	JJ
cord-326960-9phlylce	26	3	as	as	IN
cord-326960-9phlylce	26	4	protein	protein	NN
cord-326960-9phlylce	26	5	complexity	complexity	NN
cord-326960-9phlylce	26	6	,	,	,
cord-326960-9phlylce	26	7	post	post	JJ
cord-326960-9phlylce	26	8	-	-	JJ
cord-326960-9phlylce	26	9	translational	translational	JJ
cord-326960-9phlylce	26	10	modification	modification	NN
cord-326960-9phlylce	26	11	,	,	,
cord-326960-9phlylce	26	12	scale	scale	NN
cord-326960-9phlylce	26	13	and	and	CC
cord-326960-9phlylce	26	14	cost	cost	NN
cord-326960-9phlylce	26	15	must	must	MD
cord-326960-9phlylce	26	16	be	be	VB
cord-326960-9phlylce	26	17	considered	consider	VBN
cord-326960-9phlylce	26	18	collectively	collectively	RB
cord-326960-9phlylce	26	19	when	when	WRB
cord-326960-9phlylce	26	20	selecting	select	VBG
cord-326960-9phlylce	26	21	a	a	DT
cord-326960-9phlylce	26	22	manufacturing	manufacture	VBG
cord-326960-9phlylce	26	23	platform	platform	NN
cord-326960-9phlylce	26	24	;	;	:
cord-326960-9phlylce	26	25	these	these	DT
cord-326960-9phlylce	26	26	have	have	VBP
cord-326960-9phlylce	26	27	been	be	VBN
cord-326960-9phlylce	26	28	extensively	extensively	RB
cord-326960-9phlylce	26	29	reviewed	review	VBN
cord-326960-9phlylce	26	30	elsewhere	elsewhere	RB
cord-326960-9phlylce	26	31	[	[	-LRB-
cord-326960-9phlylce	26	32	2	2	CD
cord-326960-9phlylce	26	33	]	]	-RRB-
cord-326960-9phlylce	26	34	[	[	-LRB-
cord-326960-9phlylce	26	35	3	3	CD
cord-326960-9phlylce	26	36	]	]	-RRB-
cord-326960-9phlylce	26	37	[	[	-LRB-
cord-326960-9phlylce	26	38	4	4	CD
cord-326960-9phlylce	26	39	]	]	-RRB-
cord-326960-9phlylce	26	40	.	.	.
cord-326960-9phlylce	27	1	In	in	IN
cord-326960-9phlylce	27	2	this	this	DT
cord-326960-9phlylce	27	3	review	review	NN
cord-326960-9phlylce	27	4	,	,	,
cord-326960-9phlylce	27	5	we	-PRON-	PRP
cord-326960-9phlylce	27	6	explore	explore	VBP
cord-326960-9phlylce	27	7	the	the	DT
cord-326960-9phlylce	27	8	BEVS	BEVS	NNP
cord-326960-9phlylce	27	9	platform	platform	NN
cord-326960-9phlylce	27	10	by	by	IN
cord-326960-9phlylce	27	11	looking	look	VBG
cord-326960-9phlylce	27	12	at	at	IN
cord-326960-9phlylce	27	13	how	how	WRB
cord-326960-9phlylce	27	14	the	the	DT
cord-326960-9phlylce	27	15	system	system	NN
cord-326960-9phlylce	27	16	works	work	VBZ
cord-326960-9phlylce	27	17	and	and	CC
cord-326960-9phlylce	27	18	the	the	DT
cord-326960-9phlylce	27	19	advantages	advantage	NNS
cord-326960-9phlylce	27	20	and	and	CC
cord-326960-9phlylce	27	21	limitations	limitation	NNS
cord-326960-9phlylce	27	22	of	of	IN
cord-326960-9phlylce	27	23	the	the	DT
cord-326960-9phlylce	27	24	platform	platform	NN
cord-326960-9phlylce	27	25	from	from	IN
cord-326960-9phlylce	27	26	a	a	DT
cord-326960-9phlylce	27	27	manufacturing	manufacturing	NN
cord-326960-9phlylce	27	28	and	and	CC
cord-326960-9phlylce	27	29	regulatory	regulatory	JJ
cord-326960-9phlylce	27	30	perspective	perspective	NN
cord-326960-9phlylce	27	31	.	.	.
cord-326960-9phlylce	28	1	The	the	DT
cord-326960-9phlylce	28	2	opportunities	opportunity	NNS
cord-326960-9phlylce	28	3	to	to	TO
cord-326960-9phlylce	28	4	develop	develop	VB
cord-326960-9phlylce	28	5	new	new	JJ
cord-326960-9phlylce	28	6	products	product	NNS
cord-326960-9phlylce	28	7	using	use	VBG
cord-326960-9phlylce	28	8	BEVS	BEVS	NNP
cord-326960-9phlylce	28	9	are	be	VBP
cord-326960-9phlylce	28	10	abundant	abundant	JJ
cord-326960-9phlylce	28	11	,	,	,
cord-326960-9phlylce	28	12	and	and	CC
cord-326960-9phlylce	28	13	we	-PRON-	PRP
cord-326960-9phlylce	28	14	review	review	VBP
cord-326960-9phlylce	28	15	the	the	DT
cord-326960-9phlylce	28	16	latest	late	JJS
cord-326960-9phlylce	28	17	developments	development	NNS
cord-326960-9phlylce	28	18	in	in	IN
cord-326960-9phlylce	28	19	the	the	DT
cord-326960-9phlylce	28	20	gene	gene	NN
cord-326960-9phlylce	28	21	therapy	therapy	NN
cord-326960-9phlylce	28	22	and	and	CC
cord-326960-9phlylce	28	23	influenza	influenza	NN
cord-326960-9phlylce	28	24	vaccine	vaccine	NN
cord-326960-9phlylce	28	25	fields	field	NNS
cord-326960-9phlylce	28	26	as	as	IN
cord-326960-9phlylce	28	27	examples	example	NNS
cord-326960-9phlylce	28	28	.	.	.
cord-326960-9phlylce	29	1	Finally	finally	RB
cord-326960-9phlylce	29	2	,	,	,
cord-326960-9phlylce	29	3	we	-PRON-	PRP
cord-326960-9phlylce	29	4	consider	consider	VBP
cord-326960-9phlylce	29	5	some	some	DT
cord-326960-9phlylce	29	6	newer	new	JJR
cord-326960-9phlylce	29	7	areas	area	NNS
cord-326960-9phlylce	29	8	where	where	WRB
cord-326960-9phlylce	29	9	BEVS	bevs	NN
cord-326960-9phlylce	29	10	-	-	HYPH
cord-326960-9phlylce	29	11	derived	derive	VBN
cord-326960-9phlylce	29	12	products	product	NNS
cord-326960-9phlylce	29	13	show	show	VBP
cord-326960-9phlylce	29	14	promise	promise	NN
cord-326960-9phlylce	29	15	for	for	IN
cord-326960-9phlylce	29	16	the	the	DT
cord-326960-9phlylce	29	17	future	future	NN
cord-326960-9phlylce	29	18	.	.	.
cord-326960-9phlylce	30	1	The	the	DT
cord-326960-9phlylce	30	2	BEVS	BEVS	NNP
cord-326960-9phlylce	30	3	platform	platform	NN
cord-326960-9phlylce	30	4	has	have	VBZ
cord-326960-9phlylce	30	5	been	be	VBN
cord-326960-9phlylce	30	6	previously	previously	RB
cord-326960-9phlylce	30	7	described	describe	VBN
cord-326960-9phlylce	30	8	[	[	-LRB-
cord-326960-9phlylce	30	9	1	1	CD
cord-326960-9phlylce	30	10	,	,	,
cord-326960-9phlylce	30	11	2	2	CD
cord-326960-9phlylce	30	12	,	,	,
cord-326960-9phlylce	30	13	[	[	-LRB-
cord-326960-9phlylce	30	14	5	5	CD
cord-326960-9phlylce	30	15	]	]	-RRB-
cord-326960-9phlylce	30	16	[	[	-LRB-
cord-326960-9phlylce	30	17	6	6	CD
cord-326960-9phlylce	30	18	]	]	-RRB-
cord-326960-9phlylce	30	19	[	[	-LRB-
cord-326960-9phlylce	30	20	7	7	CD
cord-326960-9phlylce	30	21	]	]	-RRB-
cord-326960-9phlylce	30	22	[	[	-LRB-
cord-326960-9phlylce	30	23	8	8	CD
cord-326960-9phlylce	30	24	]	]	-RRB-
cord-326960-9phlylce	30	25	.	.	.
cord-326960-9phlylce	31	1	The	the	DT
cord-326960-9phlylce	31	2	platform	platform	NN
cord-326960-9phlylce	31	3	takes	take	VBZ
cord-326960-9phlylce	31	4	advantage	advantage	NN
cord-326960-9phlylce	31	5	of	of	IN
cord-326960-9phlylce	31	6	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	31	7	'	'	POS
cord-326960-9phlylce	31	8	natural	natural	JJ
cord-326960-9phlylce	31	9	propensity	propensity	NN
cord-326960-9phlylce	31	10	to	to	TO
cord-326960-9phlylce	31	11	infect	infect	VB
cord-326960-9phlylce	31	12	insect	insect	NN
cord-326960-9phlylce	31	13	cells	cell	NNS
cord-326960-9phlylce	31	14	.	.	.
cord-326960-9phlylce	32	1	In	in	IN
cord-326960-9phlylce	32	2	nature	nature	NN
cord-326960-9phlylce	32	3	,	,	,
cord-326960-9phlylce	32	4	there	there	EX
cord-326960-9phlylce	32	5	are	be	VBP
cord-326960-9phlylce	32	6	more	more	JJR
cord-326960-9phlylce	32	7	than	than	IN
cord-326960-9phlylce	32	8	500	500	CD
cord-326960-9phlylce	32	9	different	different	JJ
cord-326960-9phlylce	32	10	types	type	NNS
cord-326960-9phlylce	32	11	of	of	IN
cord-326960-9phlylce	32	12	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	32	13	,	,	,
cord-326960-9phlylce	32	14	all	all	DT
cord-326960-9phlylce	32	15	of	of	IN
cord-326960-9phlylce	32	16	which	which	WDT
cord-326960-9phlylce	32	17	have	have	VBP
cord-326960-9phlylce	32	18	a	a	DT
cord-326960-9phlylce	32	19	host	host	NN
cord-326960-9phlylce	32	20	range	range	NN
cord-326960-9phlylce	32	21	restricted	restrict	VBN
cord-326960-9phlylce	32	22	to	to	IN
cord-326960-9phlylce	32	23	invertebrates	invertebrate	NNS
cord-326960-9phlylce	32	24	[	[	-LRB-
cord-326960-9phlylce	32	25	9	9	CD
cord-326960-9phlylce	32	26	]	]	-RRB-
cord-326960-9phlylce	32	27	.	.	.
cord-326960-9phlylce	33	1	In	in	IN
cord-326960-9phlylce	33	2	the	the	DT
cord-326960-9phlylce	33	3	laboratory	laboratory	NN
cord-326960-9phlylce	33	4	and	and	CC
cord-326960-9phlylce	33	5	for	for	IN
cord-326960-9phlylce	33	6	manufacturing	manufacturing	NN
cord-326960-9phlylce	33	7	purposes	purpose	NNS
cord-326960-9phlylce	33	8	,	,	,
cord-326960-9phlylce	33	9	the	the	DT
cord-326960-9phlylce	33	10	most	most	RBS
cord-326960-9phlylce	33	11	commonly	commonly	RB
cord-326960-9phlylce	33	12	used	use	VBN
cord-326960-9phlylce	33	13	baculovirus	baculovirus	NN
cord-326960-9phlylce	33	14	is	be	VBZ
cord-326960-9phlylce	33	15	Autographa	Autographa	NNP
cord-326960-9phlylce	33	16	californica	californica	NN
cord-326960-9phlylce	33	17	multiple	multiple	JJ
cord-326960-9phlylce	33	18	-	-	HYPH
cord-326960-9phlylce	33	19	capsid	capsid	JJ
cord-326960-9phlylce	33	20	nuclear	nuclear	JJ
cord-326960-9phlylce	33	21	polyhedrosis	polyhedrosis	NN
cord-326960-9phlylce	33	22	virus	virus	NN
cord-326960-9phlylce	33	23	(	(	-LRB-
cord-326960-9phlylce	33	24	AcMNPV	AcMNPV	NNP
cord-326960-9phlylce	33	25	)	)	-RRB-
cord-326960-9phlylce	33	26	,	,	,
cord-326960-9phlylce	33	27	a	a	DT
cord-326960-9phlylce	33	28	virus	virus	NN
cord-326960-9phlylce	33	29	with	with	IN
cord-326960-9phlylce	33	30	a	a	DT
cord-326960-9phlylce	33	31	double	double	RB
cord-326960-9phlylce	33	32	-	-	HYPH
cord-326960-9phlylce	33	33	stranded	strand	VBN
cord-326960-9phlylce	33	34	DNA	dna	NN
cord-326960-9phlylce	33	35	genome	genome	NN
cord-326960-9phlylce	33	36	of	of	IN
cord-326960-9phlylce	33	37	approximately	approximately	RB
cord-326960-9phlylce	33	38	134	134	CD
cord-326960-9phlylce	33	39	kb	kb	NNP
cord-326960-9phlylce	33	40	[	[	-LRB-
cord-326960-9phlylce	33	41	10	10	CD
cord-326960-9phlylce	33	42	]	]	-RRB-
cord-326960-9phlylce	33	43	.	.	.
cord-326960-9phlylce	34	1	The	the	DT
cord-326960-9phlylce	34	2	large	large	JJ
cord-326960-9phlylce	34	3	size	size	NN
cord-326960-9phlylce	34	4	of	of	IN
cord-326960-9phlylce	34	5	its	-PRON-	PRP$
cord-326960-9phlylce	34	6	genome	genome	NN
cord-326960-9phlylce	34	7	gives	give	VBZ
cord-326960-9phlylce	34	8	the	the	DT
cord-326960-9phlylce	34	9	baculovirus	baculovirus	NNP
cord-326960-9phlylce	34	10	ample	ample	JJ
cord-326960-9phlylce	34	11	capacity	capacity	NN
cord-326960-9phlylce	34	12	to	to	TO
cord-326960-9phlylce	34	13	accommodate	accommodate	VB
cord-326960-9phlylce	34	14	large	large	JJ
cord-326960-9phlylce	34	15	amounts	amount	NNS
cord-326960-9phlylce	34	16	of	of	IN
cord-326960-9phlylce	34	17	foreign	foreign	JJ
cord-326960-9phlylce	34	18	DNA	dna	NN
cord-326960-9phlylce	34	19	,	,	,
cord-326960-9phlylce	34	20	including	include	VBG
cord-326960-9phlylce	34	21	multiple	multiple	JJ
cord-326960-9phlylce	34	22	genes	gene	NNS
cord-326960-9phlylce	34	23	,	,	,
cord-326960-9phlylce	34	24	an	an	DT
cord-326960-9phlylce	34	25	advantage	advantage	NN
cord-326960-9phlylce	34	26	over	over	IN
cord-326960-9phlylce	34	27	other	other	JJ
cord-326960-9phlylce	34	28	expression	expression	NN
cord-326960-9phlylce	34	29	vectors	vector	NNS
cord-326960-9phlylce	34	30	such	such	JJ
cord-326960-9phlylce	34	31	as	as	IN
cord-326960-9phlylce	34	32	vaccinia	vaccinia	NN
cord-326960-9phlylce	34	33	and	and	CC
cord-326960-9phlylce	34	34	adenovirus	adenovirus	NN
cord-326960-9phlylce	34	35	[	[	-LRB-
cord-326960-9phlylce	34	36	2	2	CD
cord-326960-9phlylce	34	37	]	]	-RRB-
cord-326960-9phlylce	34	38	.	.	.
cord-326960-9phlylce	35	1	To	to	TO
cord-326960-9phlylce	35	2	begin	begin	VB
cord-326960-9phlylce	35	3	the	the	DT
cord-326960-9phlylce	35	4	BEVS	bevs	NN
cord-326960-9phlylce	35	5	process	process	NN
cord-326960-9phlylce	35	6	,	,	,
cord-326960-9phlylce	35	7	a	a	DT
cord-326960-9phlylce	35	8	recombinant	recombinant	JJ
cord-326960-9phlylce	35	9	baculovirus	baculovirus	NN
cord-326960-9phlylce	35	10	is	be	VBZ
cord-326960-9phlylce	35	11	constructed	construct	VBN
cord-326960-9phlylce	35	12	comprising	comprise	VBG
cord-326960-9phlylce	35	13	the	the	DT
cord-326960-9phlylce	35	14	desired	desire	VBN
cord-326960-9phlylce	35	15	gene(s	gene(s	NNP
cord-326960-9phlylce	35	16	)	)	-RRB-
cord-326960-9phlylce	35	17	of	of	IN
cord-326960-9phlylce	35	18	interest	interest	NN
cord-326960-9phlylce	35	19	(	(	-LRB-
cord-326960-9phlylce	35	20	GOI	GOI	NNP
cord-326960-9phlylce	35	21	)	)	-RRB-
cord-326960-9phlylce	36	1	(	(	-LRB-
cord-326960-9phlylce	36	2	Fig	Fig	NNP
cord-326960-9phlylce	36	3	.	.	.
cord-326960-9phlylce	37	1	1	1	LS
cord-326960-9phlylce	37	2	)	)	-RRB-
cord-326960-9phlylce	37	3	.	.	.
cord-326960-9phlylce	38	1	First	first	RB
cord-326960-9phlylce	38	2	,	,	,
cord-326960-9phlylce	38	3	the	the	DT
cord-326960-9phlylce	38	4	GOI	GOI	NNP
cord-326960-9phlylce	38	5	is	be	VBZ
cord-326960-9phlylce	38	6	cloned	clone	VBN
cord-326960-9phlylce	38	7	into	into	IN
cord-326960-9phlylce	38	8	a	a	DT
cord-326960-9phlylce	38	9	transfer	transfer	NN
cord-326960-9phlylce	38	10	plasmid	plasmid	NN
cord-326960-9phlylce	38	11	,	,	,
cord-326960-9phlylce	38	12	typically	typically	RB
cord-326960-9phlylce	38	13	behind	behind	IN
cord-326960-9phlylce	38	14	the	the	DT
cord-326960-9phlylce	38	15	strong	strong	JJ
cord-326960-9phlylce	38	16	polyhedrin	polyhedrin	NNS
cord-326960-9phlylce	38	17	or	or	CC
cord-326960-9phlylce	38	18	p10	p10	NN
cord-326960-9phlylce	38	19	promoter	promoter	NN
cord-326960-9phlylce	38	20	that	that	WDT
cord-326960-9phlylce	38	21	can	can	MD
cord-326960-9phlylce	38	22	drive	drive	VB
cord-326960-9phlylce	38	23	protein	protein	NN
cord-326960-9phlylce	38	24	expression	expression	NN
cord-326960-9phlylce	38	25	to	to	IN
cord-326960-9phlylce	38	26	high	high	JJ
cord-326960-9phlylce	38	27	levels	level	NNS
cord-326960-9phlylce	38	28	in	in	IN
cord-326960-9phlylce	38	29	insect	insect	NN
cord-326960-9phlylce	38	30	cells	cell	NNS
cord-326960-9phlylce	38	31	[	[	-LRB-
cord-326960-9phlylce	38	32	11	11	CD
cord-326960-9phlylce	38	33	,	,	,
cord-326960-9phlylce	38	34	12	12	CD
cord-326960-9phlylce	38	35	]	]	-RRB-
cord-326960-9phlylce	38	36	;	;	:
cord-326960-9phlylce	38	37	notably	notably	RB
cord-326960-9phlylce	38	38	,	,	,
cord-326960-9phlylce	38	39	these	these	DT
cord-326960-9phlylce	38	40	promoters	promoter	NNS
cord-326960-9phlylce	38	41	are	be	VBP
cord-326960-9phlylce	38	42	not	not	RB
cord-326960-9phlylce	38	43	very	very	RB
cord-326960-9phlylce	38	44	active	active	JJ
cord-326960-9phlylce	38	45	in	in	IN
cord-326960-9phlylce	38	46	E.	E.	NNP
cord-326960-9phlylce	38	47	coli	coli	NNS
cord-326960-9phlylce	38	48	and	and	CC
cord-326960-9phlylce	38	49	,	,	,
cord-326960-9phlylce	38	50	therefore	therefore	RB
cord-326960-9phlylce	38	51	,	,	,
cord-326960-9phlylce	38	52	can	can	MD
cord-326960-9phlylce	38	53	be	be	VB
cord-326960-9phlylce	38	54	stable	stable	JJ
cord-326960-9phlylce	38	55	expression	expression	NN
cord-326960-9phlylce	38	56	cassettes	cassette	NNS
cord-326960-9phlylce	38	57	.	.	.
cord-326960-9phlylce	39	1	The	the	DT
cord-326960-9phlylce	39	2	GOI	GOI	NNP
cord-326960-9phlylce	39	3	is	be	VBZ
cord-326960-9phlylce	39	4	flanked	flank	VBN
cord-326960-9phlylce	39	5	by	by	IN
cord-326960-9phlylce	39	6	AcMNPV	acmnpv	NN
cord-326960-9phlylce	39	7	DNA	DNA	NNP
cord-326960-9phlylce	39	8	,	,	,
cord-326960-9phlylce	39	9	e.g.	e.g.	IN
cord-326960-9phlylce	39	10	the	the	DT
cord-326960-9phlylce	39	11	polyhedrin	polyhedrin	NN
cord-326960-9phlylce	39	12	promoter	promoter	NN
cord-326960-9phlylce	39	13	on	on	IN
cord-326960-9phlylce	39	14	one	one	CD
cord-326960-9phlylce	39	15	side	side	NN
cord-326960-9phlylce	39	16	and	and	CC
cord-326960-9phlylce	39	17	a	a	DT
cord-326960-9phlylce	39	18	portion	portion	NN
cord-326960-9phlylce	39	19	of	of	IN
cord-326960-9phlylce	39	20	the	the	DT
cord-326960-9phlylce	39	21	essential	essential	JJ
cord-326960-9phlylce	39	22	gene	gene	NN
cord-326960-9phlylce	39	23	ORF1629	ORF1629	NNP
cord-326960-9phlylce	39	24	on	on	IN
cord-326960-9phlylce	39	25	the	the	DT
cord-326960-9phlylce	39	26	other	other	JJ
cord-326960-9phlylce	39	27	.	.	.
cord-326960-9phlylce	40	1	Insect	insect	NN
cord-326960-9phlylce	40	2	cells	cell	NNS
cord-326960-9phlylce	40	3	are	be	VBP
cord-326960-9phlylce	40	4	then	then	RB
cord-326960-9phlylce	40	5	co	co	VBN
cord-326960-9phlylce	40	6	-	-	VBN
cord-326960-9phlylce	40	7	transfected	transfecte	VBN
cord-326960-9phlylce	40	8	with	with	IN
cord-326960-9phlylce	40	9	a	a	DT
cord-326960-9phlylce	40	10	mixture	mixture	NN
cord-326960-9phlylce	40	11	of	of	IN
cord-326960-9phlylce	40	12	the	the	DT
cord-326960-9phlylce	40	13	transfer	transfer	NN
cord-326960-9phlylce	40	14	plasmid	plasmid	NN
cord-326960-9phlylce	40	15	and	and	CC
cord-326960-9phlylce	40	16	parental	parental	JJ
cord-326960-9phlylce	40	17	AcMNPV	acmnpv	NN
cord-326960-9phlylce	40	18	DNA	DNA	NNP
cord-326960-9phlylce	40	19	that	that	WDT
cord-326960-9phlylce	40	20	has	have	VBZ
cord-326960-9phlylce	40	21	been	be	VBN
cord-326960-9phlylce	40	22	linearized	linearize	VBN
cord-326960-9phlylce	40	23	such	such	JJ
cord-326960-9phlylce	40	24	that	that	IN
cord-326960-9phlylce	40	25	the	the	DT
cord-326960-9phlylce	40	26	parental	parental	JJ
cord-326960-9phlylce	40	27	polyhedrin	polyhedrin	NN
cord-326960-9phlylce	40	28	gene	gene	NN
cord-326960-9phlylce	40	29	and	and	CC
cord-326960-9phlylce	40	30	portion	portion	NN
cord-326960-9phlylce	40	31	of	of	IN
cord-326960-9phlylce	40	32	ORF1629	ORF1629	NNP
cord-326960-9phlylce	40	33	are	be	VBP
cord-326960-9phlylce	40	34	missing	miss	VBG
cord-326960-9phlylce	40	35	,	,	,
cord-326960-9phlylce	40	36	rendering	render	VBG
cord-326960-9phlylce	40	37	it	-PRON-	PRP
cord-326960-9phlylce	40	38	non	non	JJ
cord-326960-9phlylce	40	39	-	-	JJ
cord-326960-9phlylce	40	40	infectious	infectious	JJ
cord-326960-9phlylce	40	41	[	[	-LRB-
cord-326960-9phlylce	40	42	13	13	CD
cord-326960-9phlylce	40	43	]	]	-RRB-
cord-326960-9phlylce	40	44	.	.	.
cord-326960-9phlylce	41	1	The	the	DT
cord-326960-9phlylce	41	2	plasmid	plasmid	NN
cord-326960-9phlylce	41	3	and	and	CC
cord-326960-9phlylce	41	4	parental	parental	JJ
cord-326960-9phlylce	41	5	DNA	dna	NN
cord-326960-9phlylce	41	6	undergo	undergo	VBP
cord-326960-9phlylce	41	7	homologous	homologous	JJ
cord-326960-9phlylce	41	8	recombination	recombination	NN
cord-326960-9phlylce	41	9	to	to	TO
cord-326960-9phlylce	41	10	generate	generate	VB
cord-326960-9phlylce	41	11	de	de	NNP
cord-326960-9phlylce	41	12	novo	novo	NNP
cord-326960-9phlylce	41	13	recombinant	recombinant	JJ
cord-326960-9phlylce	41	14	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	41	15	.	.	.
cord-326960-9phlylce	42	1	These	these	DT
cord-326960-9phlylce	42	2	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	42	3	are	be	VBP
cord-326960-9phlylce	42	4	plated	plate	VBN
cord-326960-9phlylce	42	5	and	and	CC
cord-326960-9phlylce	42	6	individual	individual	JJ
cord-326960-9phlylce	42	7	plaques	plaque	NNS
cord-326960-9phlylce	42	8	purified	purify	VBN
cord-326960-9phlylce	42	9	to	to	TO
cord-326960-9phlylce	42	10	isolate	isolate	VB
cord-326960-9phlylce	42	11	a	a	DT
cord-326960-9phlylce	42	12	single	single	JJ
cord-326960-9phlylce	42	13	,	,	,
cord-326960-9phlylce	42	14	pure	pure	JJ
cord-326960-9phlylce	42	15	plaque	plaque	NN
cord-326960-9phlylce	42	16	of	of	IN
cord-326960-9phlylce	42	17	recombinant	recombinant	JJ
cord-326960-9phlylce	42	18	baculovirus	baculovirus	NNP
cord-326960-9phlylce	42	19	.	.	.
cord-326960-9phlylce	43	1	This	this	DT
cord-326960-9phlylce	43	2	plaque	plaque	NN
cord-326960-9phlylce	43	3	is	be	VBZ
cord-326960-9phlylce	43	4	subsequently	subsequently	RB
cord-326960-9phlylce	43	5	passaged	passage	VBN
cord-326960-9phlylce	43	6	through	through	IN
cord-326960-9phlylce	43	7	multiple	multiple	JJ
cord-326960-9phlylce	43	8	rounds	round	NNS
cord-326960-9phlylce	43	9	of	of	IN
cord-326960-9phlylce	43	10	insect	insect	NN
cord-326960-9phlylce	43	11	cell	cell	NN
cord-326960-9phlylce	43	12	infection	infection	NN
cord-326960-9phlylce	43	13	to	to	TO
cord-326960-9phlylce	43	14	generate	generate	VB
cord-326960-9phlylce	43	15	a	a	DT
cord-326960-9phlylce	43	16	high	high	JJ
cord-326960-9phlylce	43	17	-	-	HYPH
cord-326960-9phlylce	43	18	titer	titer	NN
cord-326960-9phlylce	43	19	stock	stock	NN
cord-326960-9phlylce	43	20	and	and	CC
cord-326960-9phlylce	43	21	establish	establish	VB
cord-326960-9phlylce	43	22	a	a	DT
cord-326960-9phlylce	43	23	working	work	VBG
cord-326960-9phlylce	43	24	virus	virus	NN
cord-326960-9phlylce	43	25	bank	bank	NN
cord-326960-9phlylce	43	26	(	(	-LRB-
cord-326960-9phlylce	43	27	WVB	WVB	NNP
cord-326960-9phlylce	43	28	)	)	-RRB-
cord-326960-9phlylce	43	29	that	that	WDT
cord-326960-9phlylce	43	30	can	can	MD
cord-326960-9phlylce	43	31	be	be	VB
cord-326960-9phlylce	43	32	utilized	utilize	VBN
cord-326960-9phlylce	43	33	for	for	IN
cord-326960-9phlylce	43	34	protein	protein	NN
cord-326960-9phlylce	43	35	production	production	NN
cord-326960-9phlylce	43	36	.	.	.
cord-326960-9phlylce	44	1	For	for	IN
cord-326960-9phlylce	44	2	manufacturing	manufacturing	NN
cord-326960-9phlylce	44	3	purposes	purpose	NNS
cord-326960-9phlylce	44	4	,	,	,
cord-326960-9phlylce	44	5	it	-PRON-	PRP
cord-326960-9phlylce	44	6	is	be	VBZ
cord-326960-9phlylce	44	7	important	important	JJ
cord-326960-9phlylce	44	8	that	that	IN
cord-326960-9phlylce	44	9	WVBs	wvb	NNS
cord-326960-9phlylce	44	10	be	be	VB
cord-326960-9phlylce	44	11	stable	stable	JJ
cord-326960-9phlylce	44	12	and	and	CC
cord-326960-9phlylce	44	13	retain	retain	VB
cord-326960-9phlylce	44	14	integrity	integrity	NN
cord-326960-9phlylce	44	15	as	as	IN
cord-326960-9phlylce	44	16	virus	virus	NN
cord-326960-9phlylce	44	17	passages	passage	NNS
cord-326960-9phlylce	44	18	are	be	VBP
cord-326960-9phlylce	44	19	scaled	scale	VBN
cord-326960-9phlylce	44	20	up	up	RP
cord-326960-9phlylce	44	21	.	.	.
cord-326960-9phlylce	45	1	Laboratory	laboratory	NN
cord-326960-9phlylce	45	2	kits	kit	NNS
cord-326960-9phlylce	45	3	such	such	JJ
cord-326960-9phlylce	45	4	as	as	IN
cord-326960-9phlylce	45	5	Bac	Bac	NNP
cord-326960-9phlylce	45	6	-	-	HYPH
cord-326960-9phlylce	45	7	to	to	IN
cord-326960-9phlylce	45	8	-	-	HYPH
cord-326960-9phlylce	45	9	Bac	bac	NN
cord-326960-9phlylce	45	10	®	®	.
cord-326960-9phlylce	45	11	(	(	-LRB-
cord-326960-9phlylce	45	12	Life	Life	NNP
cord-326960-9phlylce	45	13	Technologies	Technologies	NNPS
cord-326960-9phlylce	45	14	)	)	-RRB-
cord-326960-9phlylce	45	15	that	that	WDT
cord-326960-9phlylce	45	16	employ	employ	VBP
cord-326960-9phlylce	45	17	bacmid	bacmid	NN
cord-326960-9phlylce	45	18	technology	technology	NN
cord-326960-9phlylce	45	19	have	have	VBP
cord-326960-9phlylce	45	20	been	be	VBN
cord-326960-9phlylce	45	21	developed	develop	VBN
cord-326960-9phlylce	45	22	that	that	WDT
cord-326960-9phlylce	45	23	allow	allow	VB
cord-326960-9phlylce	45	24	researchers	researcher	NNS
cord-326960-9phlylce	45	25	to	to	TO
cord-326960-9phlylce	45	26	quickly	quickly	RB
cord-326960-9phlylce	45	27	and	and	CC
cord-326960-9phlylce	45	28	easily	easily	RB
cord-326960-9phlylce	45	29	construct	construct	VB
cord-326960-9phlylce	45	30	recombinant	recombinant	JJ
cord-326960-9phlylce	45	31	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	45	32	in	in	IN
cord-326960-9phlylce	45	33	E.	E.	NNP
cord-326960-9phlylce	45	34	coli	coli	NNS
cord-326960-9phlylce	45	35	rather	rather	RB
cord-326960-9phlylce	45	36	than	than	IN
cord-326960-9phlylce	45	37	[	[	-LRB-
cord-326960-9phlylce	45	38	14	14	CD
cord-326960-9phlylce	45	39	]	]	-RRB-
cord-326960-9phlylce	45	40	.	.	.
cord-326960-9phlylce	46	1	Long	long	JJ
cord-326960-9phlylce	46	2	-	-	HYPH
cord-326960-9phlylce	46	3	term	term	NN
cord-326960-9phlylce	46	4	stability	stability	NN
cord-326960-9phlylce	46	5	of	of	IN
cord-326960-9phlylce	46	6	the	the	DT
cord-326960-9phlylce	46	7	baculovirus	baculovirus	NN
cord-326960-9phlylce	46	8	is	be	VBZ
cord-326960-9phlylce	46	9	an	an	DT
cord-326960-9phlylce	46	10	important	important	JJ
cord-326960-9phlylce	46	11	consideration	consideration	NN
cord-326960-9phlylce	46	12	if	if	IN
cord-326960-9phlylce	46	13	large	large	JJ
cord-326960-9phlylce	46	14	-	-	HYPH
cord-326960-9phlylce	46	15	scale	scale	NN
cord-326960-9phlylce	46	16	protein	protein	NN
cord-326960-9phlylce	46	17	production	production	NN
cord-326960-9phlylce	46	18	is	be	VBZ
cord-326960-9phlylce	46	19	envisioned	envision	VBN
cord-326960-9phlylce	46	20	.	.	.
cord-326960-9phlylce	47	1	Once	once	RB
cord-326960-9phlylce	47	2	a	a	DT
cord-326960-9phlylce	47	3	high	high	JJ
cord-326960-9phlylce	47	4	-	-	HYPH
cord-326960-9phlylce	47	5	titer	titer	NN
cord-326960-9phlylce	47	6	WVB	WVB	NNP
cord-326960-9phlylce	47	7	has	have	VBZ
cord-326960-9phlylce	47	8	been	be	VBN
cord-326960-9phlylce	47	9	established	establish	VBN
cord-326960-9phlylce	47	10	it	-PRON-	PRP
cord-326960-9phlylce	47	11	is	be	VBZ
cord-326960-9phlylce	47	12	used	use	VBN
cord-326960-9phlylce	47	13	to	to	TO
cord-326960-9phlylce	47	14	infect	infect	VB
cord-326960-9phlylce	47	15	insect	insect	NN
cord-326960-9phlylce	47	16	cells	cell	NNS
cord-326960-9phlylce	47	17	and	and	CC
cord-326960-9phlylce	47	18	stimulate	stimulate	VB
cord-326960-9phlylce	47	19	protein	protein	NN
cord-326960-9phlylce	47	20	production	production	NN
cord-326960-9phlylce	47	21	.	.	.
cord-326960-9phlylce	48	1	Cells	cell	NNS
cord-326960-9phlylce	48	2	are	be	VBP
cord-326960-9phlylce	48	3	seeded	seed	VBN
cord-326960-9phlylce	48	4	in	in	IN
cord-326960-9phlylce	48	5	culture	culture	NN
cord-326960-9phlylce	48	6	flasks	flask	NNS
cord-326960-9phlylce	48	7	(	(	-LRB-
cord-326960-9phlylce	48	8	for	for	IN
cord-326960-9phlylce	48	9	small	small	JJ
cord-326960-9phlylce	48	10	-	-	HYPH
cord-326960-9phlylce	48	11	scale	scale	NN
cord-326960-9phlylce	48	12	production	production	NN
cord-326960-9phlylce	48	13	)	)	-RRB-
cord-326960-9phlylce	48	14	or	or	CC
cord-326960-9phlylce	48	15	bioreactors	bioreactor	NNS
cord-326960-9phlylce	48	16	(	(	-LRB-
cord-326960-9phlylce	48	17	for	for	IN
cord-326960-9phlylce	48	18	large	large	JJ
cord-326960-9phlylce	48	19	-	-	HYPH
cord-326960-9phlylce	48	20	scale	scale	NN
cord-326960-9phlylce	48	21	production	production	NN
cord-326960-9phlylce	48	22	)	)	-RRB-
cord-326960-9phlylce	48	23	and	and	CC
cord-326960-9phlylce	48	24	the	the	DT
cord-326960-9phlylce	48	25	WVB	WVB	NNP
cord-326960-9phlylce	48	26	added	add	VBD
cord-326960-9phlylce	48	27	to	to	TO
cord-326960-9phlylce	48	28	infect	infect	VB
cord-326960-9phlylce	48	29	the	the	DT
cord-326960-9phlylce	48	30	insect	insect	NN
cord-326960-9phlylce	48	31	cells	cell	NNS
cord-326960-9phlylce	48	32	when	when	WRB
cord-326960-9phlylce	48	33	they	-PRON-	PRP
cord-326960-9phlylce	48	34	are	be	VBP
cord-326960-9phlylce	48	35	in	in	IN
cord-326960-9phlylce	48	36	their	-PRON-	PRP$
cord-326960-9phlylce	48	37	logarithmic	logarithmic	JJ
cord-326960-9phlylce	48	38	growth	growth	NN
cord-326960-9phlylce	48	39	phase	phase	NN
cord-326960-9phlylce	48	40	.	.	.
cord-326960-9phlylce	49	1	The	the	DT
cord-326960-9phlylce	49	2	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	49	3	reprogram	reprogram	VBP
cord-326960-9phlylce	49	4	the	the	DT
cord-326960-9phlylce	49	5	cellular	cellular	JJ
cord-326960-9phlylce	49	6	machinery	machinery	NN
cord-326960-9phlylce	49	7	to	to	TO
cord-326960-9phlylce	49	8	produce	produce	VB
cord-326960-9phlylce	49	9	the	the	DT
cord-326960-9phlylce	49	10	recombinant	recombinant	JJ
cord-326960-9phlylce	49	11	protein(s	protein(s	NNP
cord-326960-9phlylce	49	12	)	)	-RRB-
cord-326960-9phlylce	49	13	.	.	.
cord-326960-9phlylce	50	1	Following	follow	VBG
cord-326960-9phlylce	50	2	protein	protein	NN
cord-326960-9phlylce	50	3	expression	expression	NN
cord-326960-9phlylce	50	4	(	(	-LRB-
cord-326960-9phlylce	50	5	typically	typically	RB
cord-326960-9phlylce	50	6	48	48	CD
cord-326960-9phlylce	50	7	-	-	SYM
cord-326960-9phlylce	50	8	96	96	CD
cord-326960-9phlylce	50	9	hours	hour	NNS
cord-326960-9phlylce	50	10	post	post	NN
cord-326960-9phlylce	50	11	-	-	NN
cord-326960-9phlylce	50	12	infection	infection	JJ
cord-326960-9phlylce	50	13	)	)	-RRB-
cord-326960-9phlylce	50	14	,	,	,
cord-326960-9phlylce	50	15	the	the	DT
cord-326960-9phlylce	50	16	cells	cell	NNS
cord-326960-9phlylce	50	17	and/or	and/or	CC
cord-326960-9phlylce	50	18	supernatant	supernatant	JJ
cord-326960-9phlylce	50	19	are	be	VBP
cord-326960-9phlylce	50	20	harvested	harvest	VBN
cord-326960-9phlylce	50	21	,	,	,
cord-326960-9phlylce	50	22	depending	depend	VBG
cord-326960-9phlylce	50	23	on	on	IN
cord-326960-9phlylce	50	24	whether	whether	IN
cord-326960-9phlylce	50	25	the	the	DT
cord-326960-9phlylce	50	26	product	product	NN
cord-326960-9phlylce	50	27	is	be	VBZ
cord-326960-9phlylce	50	28	intracellular	intracellular	JJ
cord-326960-9phlylce	50	29	or	or	CC
cord-326960-9phlylce	50	30	secreted	secrete	VBN
cord-326960-9phlylce	50	31	,	,	,
cord-326960-9phlylce	50	32	respectively	respectively	RB
cord-326960-9phlylce	50	33	,	,	,
cord-326960-9phlylce	50	34	and	and	CC
cord-326960-9phlylce	50	35	the	the	DT
cord-326960-9phlylce	50	36	proteins	protein	NNS
cord-326960-9phlylce	50	37	are	be	VBP
cord-326960-9phlylce	50	38	purified	purify	VBN
cord-326960-9phlylce	50	39	according	accord	VBG
cord-326960-9phlylce	50	40	to	to	IN
cord-326960-9phlylce	50	41	standard	standard	JJ
cord-326960-9phlylce	50	42	techniques	technique	NNS
cord-326960-9phlylce	50	43	such	such	JJ
cord-326960-9phlylce	50	44	as	as	IN
cord-326960-9phlylce	50	45	ultracentrifugation	ultracentrifugation	NN
cord-326960-9phlylce	50	46	or	or	CC
cord-326960-9phlylce	50	47	column	column	NN
cord-326960-9phlylce	50	48	chromatography	chromatography	NN
cord-326960-9phlylce	50	49	.	.	.
cord-326960-9phlylce	51	1	Many	many	JJ
cord-326960-9phlylce	51	2	different	different	JJ
cord-326960-9phlylce	51	3	insect	insect	NN
cord-326960-9phlylce	51	4	cell	cell	NN
cord-326960-9phlylce	51	5	lines	line	NNS
cord-326960-9phlylce	51	6	have	have	VBP
cord-326960-9phlylce	51	7	been	be	VBN
cord-326960-9phlylce	51	8	used	use	VBN
cord-326960-9phlylce	51	9	for	for	IN
cord-326960-9phlylce	51	10	BEVS	BEVS	NNP
cord-326960-9phlylce	51	11	but	but	CC
cord-326960-9phlylce	51	12	the	the	DT
cord-326960-9phlylce	51	13	most	most	RBS
cord-326960-9phlylce	51	14	common	common	JJ
cord-326960-9phlylce	51	15	are	be	VBP
cord-326960-9phlylce	51	16	derived	derive	VBN
cord-326960-9phlylce	51	17	from	from	IN
cord-326960-9phlylce	51	18	ovarian	ovarian	JJ
cord-326960-9phlylce	51	19	cells	cell	NNS
cord-326960-9phlylce	51	20	of	of	IN
cord-326960-9phlylce	51	21	the	the	DT
cord-326960-9phlylce	51	22	Fall	Fall	NNP
cord-326960-9phlylce	51	23	Army	Army	NNP
cord-326960-9phlylce	51	24	Worm	Worm	NNP
cord-326960-9phlylce	51	25	,	,	,
cord-326960-9phlylce	51	26	Spodoptera	Spodoptera	NNP
cord-326960-9phlylce	51	27	frugiperda	frugiperda	NN
cord-326960-9phlylce	51	28	(	(	-LRB-
cord-326960-9phlylce	51	29	e.g.	e.g.	RB
cord-326960-9phlylce	51	30	,	,	,
cord-326960-9phlylce	51	31	Sf-21	Sf-21	NNP
cord-326960-9phlylce	51	32	,	,	,
cord-326960-9phlylce	51	33	Sf-9	Sf-9	NNP
cord-326960-9phlylce	51	34	and	and	CC
cord-326960-9phlylce	51	35	expresSF+	expresSF+	NNP
cord-326960-9phlylce	52	1	®	®	VB
cord-326960-9phlylce	52	2	[	[	-LRB-
cord-326960-9phlylce	52	3	Protein	Protein	NNP
cord-326960-9phlylce	52	4	Sciences	Sciences	NNPS
cord-326960-9phlylce	52	5	Corporation	Corporation	NNP
cord-326960-9phlylce	52	6	]	]	-RRB-
cord-326960-9phlylce	52	7	)	)	-RRB-
cord-326960-9phlylce	52	8	,	,	,
cord-326960-9phlylce	52	9	and	and	CC
cord-326960-9phlylce	52	10	the	the	DT
cord-326960-9phlylce	52	11	Cabbage	Cabbage	NNP
cord-326960-9phlylce	52	12	Looper	Looper	NNP
cord-326960-9phlylce	52	13	,	,	,
cord-326960-9phlylce	52	14	Trichoplusia	Trichoplusia	NNP
cord-326960-9phlylce	52	15	ni	ni	NNP
cord-326960-9phlylce	52	16	(	(	-LRB-
cord-326960-9phlylce	52	17	High	high	JJ
cord-326960-9phlylce	52	18	Five	five	CD
cord-326960-9phlylce	52	19	TM	TM	NNP
cord-326960-9phlylce	52	20	Cells	cell	NNS
cord-326960-9phlylce	52	21	,	,	,
cord-326960-9phlylce	52	22	Life	Life	NNP
cord-326960-9phlylce	52	23	Technologies	Technologies	NNPS
cord-326960-9phlylce	52	24	)	)	-RRB-
cord-326960-9phlylce	53	1	[	[	-LRB-
cord-326960-9phlylce	53	2	5	5	CD
cord-326960-9phlylce	53	3	,	,	,
cord-326960-9phlylce	53	4	15	15	CD
cord-326960-9phlylce	53	5	,	,	,
cord-326960-9phlylce	53	6	16	16	CD
cord-326960-9phlylce	53	7	]	]	-RRB-
cord-326960-9phlylce	53	8	.	.	.
cord-326960-9phlylce	54	1	High	high	JJ
cord-326960-9phlylce	54	2	Five	five	CD
cord-326960-9phlylce	54	3	Cells	cell	NNS
cord-326960-9phlylce	54	4	are	be	VBP
cord-326960-9phlylce	54	5	used	use	VBN
cord-326960-9phlylce	54	6	to	to	TO
cord-326960-9phlylce	54	7	manufacture	manufacture	VB
cord-326960-9phlylce	54	8	the	the	DT
cord-326960-9phlylce	54	9	licensed	licensed	JJ
cord-326960-9phlylce	54	10	human	human	JJ
cord-326960-9phlylce	54	11	papillomavirus	papillomavirus	NN
cord-326960-9phlylce	54	12	vaccine	vaccine	NN
cord-326960-9phlylce	54	13	,	,	,
cord-326960-9phlylce	54	14	Cervarix	Cervarix	NNP
cord-326960-9phlylce	54	15	®	®	POS
cord-326960-9phlylce	54	16	(	(	-LRB-
cord-326960-9phlylce	54	17	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-326960-9phlylce	54	18	)	)	-RRB-
cord-326960-9phlylce	54	19	,	,	,
cord-326960-9phlylce	54	20	and	and	CC
cord-326960-9phlylce	54	21	Sf-21	Sf-21	NNP
cord-326960-9phlylce	54	22	cells	cell	NNS
cord-326960-9phlylce	54	23	are	be	VBP
cord-326960-9phlylce	54	24	used	use	VBN
cord-326960-9phlylce	54	25	to	to	TO
cord-326960-9phlylce	54	26	produce	produce	VB
cord-326960-9phlylce	54	27	the	the	DT
cord-326960-9phlylce	54	28	antigen	antigen	NN
cord-326960-9phlylce	54	29	used	use	VBN
cord-326960-9phlylce	54	30	in	in	IN
cord-326960-9phlylce	54	31	the	the	DT
cord-326960-9phlylce	54	32	prostate	prostate	NN
cord-326960-9phlylce	54	33	cancer	cancer	NN
cord-326960-9phlylce	54	34	immunotherapy	immunotherapy	NN
cord-326960-9phlylce	54	35	,	,	,
cord-326960-9phlylce	54	36	Provenge	Provenge	NNP
cord-326960-9phlylce	54	37	®	®	.
cord-326960-9phlylce	54	38	(	(	-LRB-
cord-326960-9phlylce	54	39	Dendreon	Dendreon	NNP
cord-326960-9phlylce	54	40	)	)	-RRB-
cord-326960-9phlylce	54	41	.	.	.
cord-326960-9phlylce	55	1	expresSF+	expresSF+	NNP
cord-326960-9phlylce	55	2	cells	cell	NNS
cord-326960-9phlylce	55	3	are	be	VBP
cord-326960-9phlylce	55	4	used	use	VBN
cord-326960-9phlylce	55	5	to	to	TO
cord-326960-9phlylce	55	6	manufacture	manufacture	VB
cord-326960-9phlylce	55	7	three	three	CD
cord-326960-9phlylce	55	8	licensed	licensed	JJ
cord-326960-9phlylce	55	9	products	product	NNS
cord-326960-9phlylce	55	10	:	:	:
cord-326960-9phlylce	55	11	Flublok	Flublok	NNP
cord-326960-9phlylce	55	12	®	®	POS
cord-326960-9phlylce	55	13	influenza	influenza	NN
cord-326960-9phlylce	55	14	vaccine	vaccine	NN
cord-326960-9phlylce	55	15	(	(	-LRB-
cord-326960-9phlylce	55	16	Protein	Protein	NNP
cord-326960-9phlylce	55	17	Sciences	Sciences	NNPS
cord-326960-9phlylce	55	18	Corporation	Corporation	NNP
cord-326960-9phlylce	55	19	)	)	-RRB-
cord-326960-9phlylce	55	20	,	,	.
cord-326960-9phlylce	56	1	Glybera	Glybera	NNP
cord-326960-9phlylce	56	2	®	®	.
cord-326960-9phlylce	57	1	gene	gene	NN
cord-326960-9phlylce	57	2	therapy	therapy	NN
cord-326960-9phlylce	57	3	for	for	IN
cord-326960-9phlylce	57	4	the	the	DT
cord-326960-9phlylce	57	5	treatment	treatment	NN
cord-326960-9phlylce	57	6	of	of	IN
cord-326960-9phlylce	57	7	familial	familial	JJ
cord-326960-9phlylce	57	8	lipoprotein	lipoprotein	NN
cord-326960-9phlylce	57	9	lipase	lipase	NN
cord-326960-9phlylce	57	10	deficiency	deficiency	NN
cord-326960-9phlylce	57	11	(	(	-LRB-
cord-326960-9phlylce	57	12	uniQure	uniqure	RB
cord-326960-9phlylce	57	13	)	)	-RRB-
cord-326960-9phlylce	57	14	,	,	,
cord-326960-9phlylce	57	15	and	and	CC
cord-326960-9phlylce	57	16	Ingelvac	Ingelvac	NNP
cord-326960-9phlylce	57	17	CircoFLEX	CircoFLEX	NNP
cord-326960-9phlylce	57	18	®	®	.
cord-326960-9phlylce	57	19	veterinary	veterinary	JJ
cord-326960-9phlylce	57	20	vaccine	vaccine	NN
cord-326960-9phlylce	57	21	to	to	TO
cord-326960-9phlylce	57	22	protect	protect	VB
cord-326960-9phlylce	57	23	against	against	IN
cord-326960-9phlylce	57	24	porcine	porcine	JJ
cord-326960-9phlylce	57	25	circovirus	circovirus	JJ
cord-326960-9phlylce	57	26	type	type	NN
cord-326960-9phlylce	57	27	2	2	CD
cord-326960-9phlylce	58	1	(	(	-LRB-
cord-326960-9phlylce	58	2	Boehringer	Boehringer	NNP
cord-326960-9phlylce	58	3	Ingelheim	Ingelheim	NNP
cord-326960-9phlylce	58	4	Vetmedica	Vetmedica	NNP
cord-326960-9phlylce	58	5	)	)	-RRB-
cord-326960-9phlylce	58	6	.	.	.
cord-326960-9phlylce	59	1	Large	large	JJ
cord-326960-9phlylce	59	2	scale	scale	NN
cord-326960-9phlylce	59	3	manufacturing	manufacturing	NN
cord-326960-9phlylce	59	4	and	and	CC
cord-326960-9phlylce	59	5	commercial	commercial	JJ
cord-326960-9phlylce	59	6	production	production	NN
cord-326960-9phlylce	59	7	require	require	VBP
cord-326960-9phlylce	59	8	specific	specific	JJ
cord-326960-9phlylce	59	9	cell	cell	NN
cord-326960-9phlylce	59	10	line	line	NN
cord-326960-9phlylce	59	11	characteristics	characteristic	NNS
cord-326960-9phlylce	59	12	such	such	JJ
cord-326960-9phlylce	59	13	as	as	IN
cord-326960-9phlylce	59	14	scalability	scalability	NN
cord-326960-9phlylce	59	15	,	,	,
cord-326960-9phlylce	59	16	high	high	JJ
cord-326960-9phlylce	59	17	yields	yield	NNS
cord-326960-9phlylce	59	18	,	,	,
cord-326960-9phlylce	59	19	the	the	DT
cord-326960-9phlylce	59	20	ability	ability	NN
cord-326960-9phlylce	59	21	to	to	TO
cord-326960-9phlylce	59	22	grow	grow	VB
cord-326960-9phlylce	59	23	in	in	IN
cord-326960-9phlylce	59	24	low	low	JJ
cord-326960-9phlylce	59	25	-	-	HYPH
cord-326960-9phlylce	59	26	cost	cost	NN
cord-326960-9phlylce	59	27	,	,	,
cord-326960-9phlylce	59	28	serum	serum	NN
cord-326960-9phlylce	59	29	-	-	HYPH
cord-326960-9phlylce	59	30	free	free	JJ
cord-326960-9phlylce	59	31	media	medium	NNS
cord-326960-9phlylce	59	32	,	,	,
cord-326960-9phlylce	59	33	and	and	CC
cord-326960-9phlylce	59	34	qualification	qualification	NN
cord-326960-9phlylce	59	35	to	to	TO
cord-326960-9phlylce	59	36	meet	meet	VB
cord-326960-9phlylce	59	37	regulatory	regulatory	JJ
cord-326960-9phlylce	59	38	agency	agency	NN
cord-326960-9phlylce	59	39	(	(	-LRB-
cord-326960-9phlylce	59	40	e.g.	e.g.	RB
cord-326960-9phlylce	59	41	FDA	FDA	NNP
cord-326960-9phlylce	59	42	,	,	,
cord-326960-9phlylce	59	43	EMA	EMA	NNP
cord-326960-9phlylce	59	44	,	,	,
cord-326960-9phlylce	59	45	etc	etc	FW
cord-326960-9phlylce	59	46	.	.	.
cord-326960-9phlylce	59	47	)	)	-RRB-
cord-326960-9phlylce	60	1	requirements	requirement	NNS
cord-326960-9phlylce	60	2	for	for	IN
cord-326960-9phlylce	60	3	purity	purity	NN
cord-326960-9phlylce	60	4	and	and	CC
cord-326960-9phlylce	60	5	safety	safety	NN
cord-326960-9phlylce	60	6	.	.	.
cord-326960-9phlylce	61	1	Characteristics	characteristic	NNS
cord-326960-9phlylce	61	2	of	of	IN
cord-326960-9phlylce	61	3	the	the	DT
cord-326960-9phlylce	61	4	BEVS	BEVS	NNP
cord-326960-9phlylce	61	5	platform	platform	NN
cord-326960-9phlylce	61	6	are	be	VBP
cord-326960-9phlylce	61	7	summarized	summarize	VBN
cord-326960-9phlylce	61	8	in	in	IN
cord-326960-9phlylce	61	9	Fig	Fig	NNP
cord-326960-9phlylce	61	10	.	.	.
cord-326960-9phlylce	62	1	2	2	LS
cord-326960-9phlylce	62	2	.	.	.
cord-326960-9phlylce	63	1	These	these	DT
cord-326960-9phlylce	63	2	features	feature	NNS
cord-326960-9phlylce	63	3	as	as	RB
cord-326960-9phlylce	63	4	well	well	RB
cord-326960-9phlylce	63	5	as	as	IN
cord-326960-9phlylce	63	6	other	other	JJ
cord-326960-9phlylce	63	7	important	important	JJ
cord-326960-9phlylce	63	8	considerations	consideration	NNS
cord-326960-9phlylce	63	9	about	about	IN
cord-326960-9phlylce	63	10	the	the	DT
cord-326960-9phlylce	63	11	technology	technology	NN
cord-326960-9phlylce	63	12	are	be	VBP
cord-326960-9phlylce	63	13	discussed	discuss	VBN
cord-326960-9phlylce	63	14	below	below	RB
cord-326960-9phlylce	63	15	.	.	.
cord-326960-9phlylce	64	1	The	the	DT
cord-326960-9phlylce	64	2	choice	choice	NN
cord-326960-9phlylce	64	3	of	of	IN
cord-326960-9phlylce	64	4	an	an	DT
cord-326960-9phlylce	64	5	expression	expression	NN
cord-326960-9phlylce	64	6	system	system	NN
cord-326960-9phlylce	64	7	for	for	IN
cord-326960-9phlylce	64	8	manufacturing	manufacturing	NN
cord-326960-9phlylce	64	9	is	be	VBZ
cord-326960-9phlylce	64	10	a	a	DT
cord-326960-9phlylce	64	11	complex	complex	JJ
cord-326960-9phlylce	64	12	decision	decision	NN
cord-326960-9phlylce	64	13	that	that	WDT
cord-326960-9phlylce	64	14	must	must	MD
cord-326960-9phlylce	64	15	balance	balance	VB
cord-326960-9phlylce	64	16	many	many	JJ
cord-326960-9phlylce	64	17	facets	facet	NNS
cord-326960-9phlylce	64	18	,	,	,
cord-326960-9phlylce	64	19	including	include	VBG
cord-326960-9phlylce	64	20	attainment	attainment	NN
cord-326960-9phlylce	64	21	of	of	IN
cord-326960-9phlylce	64	22	specific	specific	JJ
cord-326960-9phlylce	64	23	product	product	NN
cord-326960-9phlylce	64	24	features	feature	NNS
cord-326960-9phlylce	64	25	,	,	,
cord-326960-9phlylce	64	26	the	the	DT
cord-326960-9phlylce	64	27	demands	demand	NNS
cord-326960-9phlylce	64	28	of	of	IN
cord-326960-9phlylce	64	29	the	the	DT
cord-326960-9phlylce	64	30	therapeutic	therapeutic	JJ
cord-326960-9phlylce	64	31	indication	indication	NN
cord-326960-9phlylce	64	32	,	,	,
cord-326960-9phlylce	64	33	and	and	CC
cord-326960-9phlylce	64	34	the	the	DT
cord-326960-9phlylce	64	35	needs	need	NNS
cord-326960-9phlylce	64	36	of	of	IN
cord-326960-9phlylce	64	37	the	the	DT
cord-326960-9phlylce	64	38	manufacturer	manufacturer	NN
cord-326960-9phlylce	64	39	.	.	.
cord-326960-9phlylce	65	1	Comparisons	comparison	NNS
cord-326960-9phlylce	65	2	of	of	IN
cord-326960-9phlylce	65	3	the	the	DT
cord-326960-9phlylce	65	4	BEVS	BEVS	NNP
cord-326960-9phlylce	65	5	platform	platform	NN
cord-326960-9phlylce	65	6	to	to	IN
cord-326960-9phlylce	65	7	other	other	JJ
cord-326960-9phlylce	65	8	expression	expression	NN
cord-326960-9phlylce	65	9	systems	system	NNS
cord-326960-9phlylce	65	10	such	such	JJ
cord-326960-9phlylce	65	11	as	as	IN
cord-326960-9phlylce	65	12	bacteria	bacteria	NNS
cord-326960-9phlylce	65	13	,	,	,
cord-326960-9phlylce	65	14	yeast	yeast	NN
cord-326960-9phlylce	65	15	,	,	,
cord-326960-9phlylce	65	16	mammalian	mammalian	JJ
cord-326960-9phlylce	65	17	cells	cell	NNS
cord-326960-9phlylce	65	18	and	and	CC
cord-326960-9phlylce	65	19	plants	plant	NNS
cord-326960-9phlylce	65	20	have	have	VBP
cord-326960-9phlylce	65	21	been	be	VBN
cord-326960-9phlylce	65	22	made	make	VBN
cord-326960-9phlylce	65	23	and	and	CC
cord-326960-9phlylce	65	24	are	be	VBP
cord-326960-9phlylce	65	25	useful	useful	JJ
cord-326960-9phlylce	65	26	to	to	TO
cord-326960-9phlylce	65	27	consider	consider	VB
cord-326960-9phlylce	65	28	when	when	WRB
cord-326960-9phlylce	65	29	selecting	select	VBG
cord-326960-9phlylce	65	30	a	a	DT
cord-326960-9phlylce	65	31	platform	platform	NN
cord-326960-9phlylce	65	32	[	[	-LRB-
cord-326960-9phlylce	65	33	2	2	CD
cord-326960-9phlylce	65	34	]	]	-RRB-
cord-326960-9phlylce	65	35	[	[	-LRB-
cord-326960-9phlylce	65	36	3	3	CD
cord-326960-9phlylce	65	37	]	]	-RRB-
cord-326960-9phlylce	65	38	[	[	-LRB-
cord-326960-9phlylce	65	39	4	4	CD
cord-326960-9phlylce	65	40	]	]	-RRB-
cord-326960-9phlylce	65	41	.	.	.
cord-326960-9phlylce	66	1	BEVS	BEVS	NNP
cord-326960-9phlylce	66	2	employs	employ	VBZ
cord-326960-9phlylce	66	3	recombinant	recombinant	JJ
cord-326960-9phlylce	66	4	technology	technology	NN
cord-326960-9phlylce	66	5	,	,	,
cord-326960-9phlylce	66	6	giving	give	VBG
cord-326960-9phlylce	66	7	researchers	researcher	NNS
cord-326960-9phlylce	66	8	and	and	CC
cord-326960-9phlylce	66	9	product	product	NN
cord-326960-9phlylce	66	10	developers	developer	NNS
cord-326960-9phlylce	66	11	a	a	DT
cord-326960-9phlylce	66	12	level	level	NN
cord-326960-9phlylce	66	13	of	of	IN
cord-326960-9phlylce	66	14	control	control	NN
cord-326960-9phlylce	66	15	over	over	IN
cord-326960-9phlylce	66	16	the	the	DT
cord-326960-9phlylce	66	17	production	production	NN
cord-326960-9phlylce	66	18	process	process	NN
cord-326960-9phlylce	66	19	that	that	WDT
cord-326960-9phlylce	66	20	is	be	VBZ
cord-326960-9phlylce	66	21	not	not	RB
cord-326960-9phlylce	66	22	possible	possible	JJ
cord-326960-9phlylce	66	23	with	with	IN
cord-326960-9phlylce	66	24	other	other	JJ
cord-326960-9phlylce	66	25	techniques	technique	NNS
cord-326960-9phlylce	66	26	.	.	.
cord-326960-9phlylce	67	1	A	a	DT
cord-326960-9phlylce	67	2	good	good	JJ
cord-326960-9phlylce	67	3	example	example	NN
cord-326960-9phlylce	67	4	is	be	VBZ
cord-326960-9phlylce	67	5	found	find	VBN
cord-326960-9phlylce	67	6	with	with	IN
cord-326960-9phlylce	67	7	vaccine	vaccine	NN
cord-326960-9phlylce	67	8	manufacturing	manufacturing	NN
cord-326960-9phlylce	67	9	.	.	.
cord-326960-9phlylce	68	1	Traditionally	traditionally	RB
cord-326960-9phlylce	68	2	,	,	,
cord-326960-9phlylce	68	3	vaccines	vaccine	NNS
cord-326960-9phlylce	68	4	are	be	VBP
cord-326960-9phlylce	68	5	made	make	VBN
cord-326960-9phlylce	68	6	by	by	IN
cord-326960-9phlylce	68	7	cultivating	cultivate	VBG
cord-326960-9phlylce	68	8	large	large	JJ
cord-326960-9phlylce	68	9	volumes	volume	NNS
cord-326960-9phlylce	68	10	of	of	IN
cord-326960-9phlylce	68	11	the	the	DT
cord-326960-9phlylce	68	12	pathogen	pathogen	NN
cord-326960-9phlylce	68	13	against	against	IN
cord-326960-9phlylce	68	14	which	which	WDT
cord-326960-9phlylce	68	15	protection	protection	NN
cord-326960-9phlylce	68	16	is	be	VBZ
cord-326960-9phlylce	68	17	desired	desire	VBN
cord-326960-9phlylce	68	18	to	to	TO
cord-326960-9phlylce	68	19	generate	generate	VB
cord-326960-9phlylce	68	20	the	the	DT
cord-326960-9phlylce	68	21	"	"	``
cord-326960-9phlylce	68	22	raw	raw	JJ
cord-326960-9phlylce	68	23	materials	material	NNS
cord-326960-9phlylce	68	24	"	"	''
cord-326960-9phlylce	68	25	required	require	VBN
cord-326960-9phlylce	68	26	for	for	IN
cord-326960-9phlylce	68	27	the	the	DT
cord-326960-9phlylce	68	28	product	product	NN
cord-326960-9phlylce	68	29	.	.	.
cord-326960-9phlylce	69	1	This	this	DT
cord-326960-9phlylce	69	2	can	can	MD
cord-326960-9phlylce	69	3	be	be	VB
cord-326960-9phlylce	69	4	accomplished	accomplish	VBN
cord-326960-9phlylce	69	5	by	by	IN
cord-326960-9phlylce	69	6	infecting	infect	VBG
cord-326960-9phlylce	69	7	substrates	substrate	NNS
cord-326960-9phlylce	69	8	such	such	JJ
cord-326960-9phlylce	69	9	as	as	IN
cord-326960-9phlylce	69	10	embryonated	embryonate	VBN
cord-326960-9phlylce	69	11	chicken	chicken	NN
cord-326960-9phlylce	69	12	eggs	egg	NNS
cord-326960-9phlylce	69	13	or	or	CC
cord-326960-9phlylce	69	14	mammalian	mammalian	JJ
cord-326960-9phlylce	69	15	cells	cell	NNS
cord-326960-9phlylce	69	16	,	,	,
cord-326960-9phlylce	69	17	both	both	DT
cord-326960-9phlylce	69	18	of	of	IN
cord-326960-9phlylce	69	19	which	which	WDT
cord-326960-9phlylce	69	20	are	be	VBP
cord-326960-9phlylce	69	21	used	use	VBN
cord-326960-9phlylce	69	22	to	to	TO
cord-326960-9phlylce	69	23	manufacture	manufacture	VB
cord-326960-9phlylce	69	24	the	the	DT
cord-326960-9phlylce	69	25	majority	majority	NN
cord-326960-9phlylce	69	26	of	of	IN
cord-326960-9phlylce	69	27	the	the	DT
cord-326960-9phlylce	69	28	vaccines	vaccine	NNS
cord-326960-9phlylce	69	29	recommended	recommend	VBN
cord-326960-9phlylce	69	30	for	for	IN
cord-326960-9phlylce	69	31	routine	routine	JJ
cord-326960-9phlylce	69	32	immunization	immunization	NN
cord-326960-9phlylce	69	33	[	[	-LRB-
cord-326960-9phlylce	69	34	1	1	CD
cord-326960-9phlylce	69	35	,	,	,
cord-326960-9phlylce	69	36	17	17	CD
cord-326960-9phlylce	69	37	]	]	-RRB-
cord-326960-9phlylce	69	38	.	.	.
cord-326960-9phlylce	70	1	The	the	DT
cord-326960-9phlylce	70	2	pathogen	pathogen	NN
cord-326960-9phlylce	70	3	is	be	VBZ
cord-326960-9phlylce	70	4	either	either	CC
cord-326960-9phlylce	70	5	weakened	weaken	VBN
cord-326960-9phlylce	70	6	and	and	CC
cord-326960-9phlylce	70	7	administered	administer	VBN
cord-326960-9phlylce	70	8	live	live	RB
cord-326960-9phlylce	70	9	as	as	IN
cord-326960-9phlylce	70	10	a	a	DT
cord-326960-9phlylce	70	11	live	live	JJ
cord-326960-9phlylce	70	12	attenuated	attenuated	JJ
cord-326960-9phlylce	70	13	vaccine	vaccine	NN
cord-326960-9phlylce	70	14	,	,	,
cord-326960-9phlylce	70	15	or	or	CC
cord-326960-9phlylce	70	16	is	be	VBZ
cord-326960-9phlylce	70	17	killed	kill	VBN
cord-326960-9phlylce	70	18	or	or	CC
cord-326960-9phlylce	70	19	inactivated	inactivate	VBN
cord-326960-9phlylce	70	20	with	with	IN
cord-326960-9phlylce	70	21	reagents	reagent	NNS
cord-326960-9phlylce	70	22	such	such	JJ
cord-326960-9phlylce	70	23	as	as	IN
cord-326960-9phlylce	70	24	formalin	formalin	NN
cord-326960-9phlylce	70	25	or	or	CC
cord-326960-9phlylce	70	26	heat	heat	NN
cord-326960-9phlylce	70	27	prior	prior	RB
cord-326960-9phlylce	70	28	to	to	IN
cord-326960-9phlylce	70	29	being	be	VBG
cord-326960-9phlylce	70	30	formulated	formulate	VBN
cord-326960-9phlylce	70	31	into	into	IN
cord-326960-9phlylce	70	32	vaccine	vaccine	NN
cord-326960-9phlylce	70	33	.	.	.
cord-326960-9phlylce	71	1	These	these	DT
cord-326960-9phlylce	71	2	methods	method	NNS
cord-326960-9phlylce	71	3	yield	yield	VBP
cord-326960-9phlylce	71	4	safe	safe	JJ
cord-326960-9phlylce	71	5	and	and	CC
cord-326960-9phlylce	71	6	effective	effective	JJ
cord-326960-9phlylce	71	7	vaccines	vaccine	NNS
cord-326960-9phlylce	71	8	;	;	:
cord-326960-9phlylce	71	9	however	however	RB
cord-326960-9phlylce	71	10	,	,	,
cord-326960-9phlylce	71	11	important	important	JJ
cord-326960-9phlylce	71	12	shortcomings	shortcoming	NNS
cord-326960-9phlylce	71	13	have	have	VBP
cord-326960-9phlylce	71	14	been	be	VBN
cord-326960-9phlylce	71	15	observed	observe	VBN
cord-326960-9phlylce	71	16	.	.	.
cord-326960-9phlylce	72	1	The	the	DT
cord-326960-9phlylce	72	2	first	first	JJ
cord-326960-9phlylce	72	3	concerns	concern	NNS
cord-326960-9phlylce	72	4	specificity	specificity	NN
cord-326960-9phlylce	72	5	.	.	.
cord-326960-9phlylce	73	1	For	for	IN
cord-326960-9phlylce	73	2	example	example	NN
cord-326960-9phlylce	73	3	,	,	,
cord-326960-9phlylce	73	4	traditional	traditional	JJ
cord-326960-9phlylce	73	5	influenza	influenza	NN
cord-326960-9phlylce	73	6	vaccine	vaccine	NN
cord-326960-9phlylce	73	7	production	production	NN
cord-326960-9phlylce	73	8	involves	involve	VBZ
cord-326960-9phlylce	73	9	virus	virus	NN
cord-326960-9phlylce	73	10	propagation	propagation	NN
cord-326960-9phlylce	73	11	in	in	IN
cord-326960-9phlylce	73	12	eggs	egg	NNS
cord-326960-9phlylce	73	13	.	.	.
cord-326960-9phlylce	74	1	As	as	IN
cord-326960-9phlylce	74	2	influenza	influenza	NN
cord-326960-9phlylce	74	3	viruses	virus	NNS
cord-326960-9phlylce	74	4	are	be	VBP
cord-326960-9phlylce	74	5	RNA	RNA	NNP
cord-326960-9phlylce	74	6	viruses	virus	NNS
cord-326960-9phlylce	74	7	,	,	,
cord-326960-9phlylce	74	8	they	-PRON-	PRP
cord-326960-9phlylce	74	9	have	have	VBP
cord-326960-9phlylce	74	10	a	a	DT
cord-326960-9phlylce	74	11	tendency	tendency	NN
cord-326960-9phlylce	74	12	to	to	TO
cord-326960-9phlylce	74	13	mutate	mutate	VB
cord-326960-9phlylce	74	14	to	to	TO
cord-326960-9phlylce	74	15	optimize	optimize	VB
cord-326960-9phlylce	74	16	their	-PRON-	PRP$
cord-326960-9phlylce	74	17	Figure	figure	NN
cord-326960-9phlylce	74	18	1	1	CD
cord-326960-9phlylce	74	19	.	.	.
cord-326960-9phlylce	75	1	The	the	DT
cord-326960-9phlylce	75	2	BEVS	BEVS	NNP
cord-326960-9phlylce	75	3	platform	platform	NN
cord-326960-9phlylce	75	4	.	.	.
cord-326960-9phlylce	76	1	The	the	DT
cord-326960-9phlylce	76	2	BEVS	BEVS	NNP
cord-326960-9phlylce	76	3	platform	platform	NN
cord-326960-9phlylce	76	4	is	be	VBZ
cord-326960-9phlylce	76	5	an	an	DT
cord-326960-9phlylce	76	6	efficient	efficient	JJ
cord-326960-9phlylce	76	7	process	process	NN
cord-326960-9phlylce	76	8	for	for	IN
cord-326960-9phlylce	76	9	producing	produce	VBG
cord-326960-9phlylce	76	10	a	a	DT
cord-326960-9phlylce	76	11	wide	wide	JJ
cord-326960-9phlylce	76	12	variety	variety	NN
cord-326960-9phlylce	76	13	of	of	IN
cord-326960-9phlylce	76	14	proteins	protein	NNS
cord-326960-9phlylce	76	15	in	in	IN
cord-326960-9phlylce	76	16	a	a	DT
cord-326960-9phlylce	76	17	streamlined	streamlined	JJ
cord-326960-9phlylce	76	18	manner	manner	NN
cord-326960-9phlylce	76	19	.	.	.
cord-326960-9phlylce	77	1	A	a	DT
cord-326960-9phlylce	77	2	gene	gene	NN
cord-326960-9phlylce	77	3	of	of	IN
cord-326960-9phlylce	77	4	interest	interest	NN
cord-326960-9phlylce	77	5	(	(	-LRB-
cord-326960-9phlylce	77	6	GOI	GOI	NNP
cord-326960-9phlylce	77	7	)	)	-RRB-
cord-326960-9phlylce	77	8	is	be	VBZ
cord-326960-9phlylce	77	9	cloned	clone	VBN
cord-326960-9phlylce	77	10	into	into	IN
cord-326960-9phlylce	77	11	a	a	DT
cord-326960-9phlylce	77	12	transfer	transfer	NN
cord-326960-9phlylce	77	13	plasmid	plasmid	NN
cord-326960-9phlylce	77	14	behind	behind	IN
cord-326960-9phlylce	77	15	a	a	DT
cord-326960-9phlylce	77	16	strong	strong	JJ
cord-326960-9phlylce	77	17	promoter	promoter	NN
cord-326960-9phlylce	77	18	(	(	-LRB-
cord-326960-9phlylce	77	19	green	green	JJ
cord-326960-9phlylce	77	20	arrow	arrow	NN
cord-326960-9phlylce	77	21	)	)	-RRB-
cord-326960-9phlylce	77	22	and	and	CC
cord-326960-9phlylce	77	23	surrounded	surround	VBN
cord-326960-9phlylce	77	24	by	by	IN
cord-326960-9phlylce	77	25	DNA	dna	NN
cord-326960-9phlylce	77	26	homologous	homologous	JJ
cord-326960-9phlylce	77	27	to	to	IN
cord-326960-9phlylce	77	28	the	the	DT
cord-326960-9phlylce	77	29	parent	parent	NN
cord-326960-9phlylce	77	30	baculovirus	baculovirus	NNP
cord-326960-9phlylce	77	31	(	(	-LRB-
cord-326960-9phlylce	77	32	yellow	yellow	JJ
cord-326960-9phlylce	77	33	and	and	CC
cord-326960-9phlylce	77	34	green	green	JJ
cord-326960-9phlylce	77	35	boxes	box	NNS
cord-326960-9phlylce	77	36	)	)	-RRB-
cord-326960-9phlylce	77	37	.	.	.
cord-326960-9phlylce	78	1	A	a	DT
cord-326960-9phlylce	78	2	library	library	NN
cord-326960-9phlylce	78	3	of	of	IN
cord-326960-9phlylce	78	4	recombinant	recombinant	JJ
cord-326960-9phlylce	78	5	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	78	6	(	(	-LRB-
cord-326960-9phlylce	78	7	rBV	rBV	NNP
cord-326960-9phlylce	78	8	)	)	-RRB-
cord-326960-9phlylce	78	9	can	can	MD
cord-326960-9phlylce	78	10	be	be	VB
cord-326960-9phlylce	78	11	made	make	VBN
cord-326960-9phlylce	78	12	using	use	VBG
cord-326960-9phlylce	78	13	standard	standard	JJ
cord-326960-9phlylce	78	14	cloning	cloning	NN
cord-326960-9phlylce	78	15	techniques	technique	NNS
cord-326960-9phlylce	78	16	and	and	CC
cord-326960-9phlylce	78	17	varying	vary	VBG
cord-326960-9phlylce	78	18	the	the	DT
cord-326960-9phlylce	78	19	GOI	GOI	NNP
cord-326960-9phlylce	78	20	.	.	.
cord-326960-9phlylce	79	1	Construction	construction	NN
cord-326960-9phlylce	79	2	of	of	IN
cord-326960-9phlylce	79	3	an	an	DT
cord-326960-9phlylce	79	4	rBV	rbv	NN
cord-326960-9phlylce	79	5	takes	take	VBZ
cord-326960-9phlylce	79	6	eight	eight	CD
cord-326960-9phlylce	79	7	days	day	NNS
cord-326960-9phlylce	79	8	.	.	.
cord-326960-9phlylce	80	1	To	to	TO
cord-326960-9phlylce	80	2	generate	generate	VB
cord-326960-9phlylce	80	3	protein	protein	NN
cord-326960-9phlylce	80	4	,	,	,
cord-326960-9phlylce	80	5	the	the	DT
cord-326960-9phlylce	80	6	appropriate	appropriate	JJ
cord-326960-9phlylce	80	7	rBV	rbv	NN
cord-326960-9phlylce	80	8	is	be	VBZ
cord-326960-9phlylce	80	9	scaled	scale	VBN
cord-326960-9phlylce	80	10	up	up	RP
cord-326960-9phlylce	80	11	(	(	-LRB-
cord-326960-9phlylce	80	12	taking	take	VBG
cord-326960-9phlylce	80	13	on	on	RP
cord-326960-9phlylce	80	14	average	average	JJ
cord-326960-9phlylce	80	15	two	two	CD
cord-326960-9phlylce	80	16	to	to	TO
cord-326960-9phlylce	80	17	five	five	CD
cord-326960-9phlylce	80	18	weeks	week	NNS
cord-326960-9phlylce	80	19	)	)	-RRB-
cord-326960-9phlylce	80	20	and	and	CC
cord-326960-9phlylce	80	21	used	use	VBD
cord-326960-9phlylce	80	22	to	to	TO
cord-326960-9phlylce	80	23	infect	infect	VB
cord-326960-9phlylce	80	24	insect	insect	NN
cord-326960-9phlylce	80	25	cells	cell	NNS
cord-326960-9phlylce	80	26	,	,	,
cord-326960-9phlylce	80	27	which	which	WDT
cord-326960-9phlylce	80	28	programs	program	VBZ
cord-326960-9phlylce	80	29	the	the	DT
cord-326960-9phlylce	80	30	cells	cell	NNS
cord-326960-9phlylce	80	31	to	to	TO
cord-326960-9phlylce	80	32	generate	generate	VB
cord-326960-9phlylce	80	33	large	large	JJ
cord-326960-9phlylce	80	34	quantities	quantity	NNS
cord-326960-9phlylce	80	35	of	of	IN
cord-326960-9phlylce	80	36	recombinant	recombinant	JJ
cord-326960-9phlylce	80	37	protein	protein	NN
cord-326960-9phlylce	80	38	that	that	WDT
cord-326960-9phlylce	80	39	can	can	MD
cord-326960-9phlylce	80	40	subsequently	subsequently	RB
cord-326960-9phlylce	80	41	be	be	VB
cord-326960-9phlylce	80	42	purified	purify	VBN
cord-326960-9phlylce	80	43	to	to	IN
cord-326960-9phlylce	80	44	high	high	JJ
cord-326960-9phlylce	80	45	levels	level	NNS
cord-326960-9phlylce	80	46	using	use	VBG
cord-326960-9phlylce	80	47	standard	standard	JJ
cord-326960-9phlylce	80	48	techniques	technique	NNS
cord-326960-9phlylce	80	49	.	.	.
cord-326960-9phlylce	81	1	A	a	DT
cord-326960-9phlylce	81	2	single	single	JJ
cord-326960-9phlylce	81	3	insect	insect	NN
cord-326960-9phlylce	81	4	cell	cell	NN
cord-326960-9phlylce	81	5	line	line	NN
cord-326960-9phlylce	81	6	can	can	MD
cord-326960-9phlylce	81	7	be	be	VB
cord-326960-9phlylce	81	8	used	use	VBN
cord-326960-9phlylce	81	9	to	to	TO
cord-326960-9phlylce	81	10	produce	produce	VB
cord-326960-9phlylce	81	11	all	all	DT
cord-326960-9phlylce	81	12	proteins	protein	NNS
cord-326960-9phlylce	81	13	.	.	.
cord-326960-9phlylce	82	1	Protein	protein	NN
cord-326960-9phlylce	82	2	production	production	NN
cord-326960-9phlylce	82	3	averages	average	VBZ
cord-326960-9phlylce	82	4	three	three	CD
cord-326960-9phlylce	82	5	to	to	TO
cord-326960-9phlylce	82	6	five	five	CD
cord-326960-9phlylce	82	7	weeks	week	NNS
cord-326960-9phlylce	82	8	and	and	CC
cord-326960-9phlylce	82	9	yields	yield	NNS
cord-326960-9phlylce	82	10	highly	highly	RB
cord-326960-9phlylce	82	11	pure	pure	JJ
cord-326960-9phlylce	82	12	,	,	,
cord-326960-9phlylce	82	13	biologically	biologically	RB
cord-326960-9phlylce	82	14	active	active	JJ
cord-326960-9phlylce	82	15	products	product	NNS
cord-326960-9phlylce	82	16	.	.	.
cord-326960-9phlylce	83	1	growth	growth	NN
cord-326960-9phlylce	83	2	[	[	-LRB-
cord-326960-9phlylce	83	3	18	18	CD
cord-326960-9phlylce	83	4	]	]	-RRB-
cord-326960-9phlylce	83	5	.	.	.
cord-326960-9phlylce	84	1	Generally	generally	RB
cord-326960-9phlylce	84	2	,	,	,
cord-326960-9phlylce	84	3	the	the	DT
cord-326960-9phlylce	84	4	changes	change	NNS
cord-326960-9phlylce	84	5	introduced	introduce	VBN
cord-326960-9phlylce	84	6	into	into	IN
cord-326960-9phlylce	84	7	the	the	DT
cord-326960-9phlylce	84	8	virus	virus	NN
cord-326960-9phlylce	84	9	sequence	sequence	NN
cord-326960-9phlylce	84	10	have	have	VBP
cord-326960-9phlylce	84	11	little	little	JJ
cord-326960-9phlylce	84	12	impact	impact	NN
cord-326960-9phlylce	84	13	on	on	IN
cord-326960-9phlylce	84	14	vaccine	vaccine	NN
cord-326960-9phlylce	84	15	efficacy	efficacy	NN
cord-326960-9phlylce	84	16	.	.	.
cord-326960-9phlylce	85	1	However	however	RB
cord-326960-9phlylce	85	2	,	,	,
cord-326960-9phlylce	85	3	since	since	IN
cord-326960-9phlylce	85	4	the	the	DT
cord-326960-9phlylce	85	5	virus	virus	NN
cord-326960-9phlylce	85	6	receptors	receptor	NNS
cord-326960-9phlylce	85	7	for	for	IN
cord-326960-9phlylce	85	8	birds	bird	NNS
cord-326960-9phlylce	85	9	and	and	CC
cord-326960-9phlylce	85	10	mammals	mammal	NNS
cord-326960-9phlylce	85	11	differ	differ	VBP
cord-326960-9phlylce	85	12	,	,	,
cord-326960-9phlylce	85	13	these	these	DT
cord-326960-9phlylce	85	14	changes	change	NNS
cord-326960-9phlylce	85	15	can	can	MD
cord-326960-9phlylce	85	16	be	be	VB
cord-326960-9phlylce	85	17	meaningful	meaningful	JJ
cord-326960-9phlylce	85	18	,	,	,
cord-326960-9phlylce	85	19	and	and	CC
cord-326960-9phlylce	85	20	it	-PRON-	PRP
cord-326960-9phlylce	85	21	has	have	VBZ
cord-326960-9phlylce	85	22	been	be	VBN
cord-326960-9phlylce	85	23	documented	document	VBN
cord-326960-9phlylce	85	24	that	that	IN
cord-326960-9phlylce	85	25	in	in	IN
cord-326960-9phlylce	85	26	some	some	DT
cord-326960-9phlylce	85	27	cases	case	NNS
cord-326960-9phlylce	85	28	the	the	DT
cord-326960-9phlylce	85	29	changes	change	NNS
cord-326960-9phlylce	85	30	have	have	VBP
cord-326960-9phlylce	85	31	rendered	render	VBN
cord-326960-9phlylce	85	32	egg	egg	NN
cord-326960-9phlylce	85	33	-	-	HYPH
cord-326960-9phlylce	85	34	based	base	VBN
cord-326960-9phlylce	85	35	influenza	influenza	NN
cord-326960-9phlylce	85	36	vaccines	vaccine	NNS
cord-326960-9phlylce	85	37	ineffective	ineffective	JJ
cord-326960-9phlylce	85	38	[	[	-LRB-
cord-326960-9phlylce	85	39	19	19	CD
cord-326960-9phlylce	85	40	]	]	-RRB-
cord-326960-9phlylce	85	41	.	.	.
cord-326960-9phlylce	86	1	The	the	DT
cord-326960-9phlylce	86	2	BEVS	bevs	NN
cord-326960-9phlylce	86	3	process	process	NN
cord-326960-9phlylce	86	4	does	do	VBZ
cord-326960-9phlylce	86	5	not	not	RB
cord-326960-9phlylce	86	6	involve	involve	VB
cord-326960-9phlylce	86	7	pathogen	pathogen	NN
cord-326960-9phlylce	86	8	growth	growth	NN
cord-326960-9phlylce	86	9	and	and	CC
cord-326960-9phlylce	86	10	,	,	,
cord-326960-9phlylce	86	11	therefore	therefore	RB
cord-326960-9phlylce	86	12	,	,	,
cord-326960-9phlylce	86	13	avoids	avoid	VBZ
cord-326960-9phlylce	86	14	this	this	DT
cord-326960-9phlylce	86	15	complication	complication	NN
cord-326960-9phlylce	86	16	.	.	.
cord-326960-9phlylce	87	1	Rather	rather	RB
cord-326960-9phlylce	87	2	than	than	IN
cord-326960-9phlylce	87	3	cultivate	cultivate	VB
cord-326960-9phlylce	87	4	a	a	DT
cord-326960-9phlylce	87	5	pathogen	pathogen	NN
cord-326960-9phlylce	87	6	to	to	TO
cord-326960-9phlylce	87	7	collect	collect	VB
cord-326960-9phlylce	87	8	"	"	``
cord-326960-9phlylce	87	9	raw	raw	JJ
cord-326960-9phlylce	87	10	materials	material	NNS
cord-326960-9phlylce	87	11	"	"	''
cord-326960-9phlylce	87	12	,	,	,
cord-326960-9phlylce	87	13	a	a	DT
cord-326960-9phlylce	87	14	recombinant	recombinant	JJ
cord-326960-9phlylce	87	15	baculovirus	baculovirus	NN
cord-326960-9phlylce	87	16	is	be	VBZ
cord-326960-9phlylce	87	17	constructed	construct	VBN
cord-326960-9phlylce	87	18	that	that	IN
cord-326960-9phlylce	87	19	codes	code	NNS
cord-326960-9phlylce	87	20	for	for	IN
cord-326960-9phlylce	87	21	the	the	DT
cord-326960-9phlylce	87	22	antigen	antigen	NN
cord-326960-9phlylce	87	23	required	require	VBN
cord-326960-9phlylce	87	24	for	for	IN
cord-326960-9phlylce	87	25	protection	protection	NN
cord-326960-9phlylce	87	26	.	.	.
cord-326960-9phlylce	88	1	Since	since	IN
cord-326960-9phlylce	88	2	accommodations	accommodation	NNS
cord-326960-9phlylce	88	3	for	for	IN
cord-326960-9phlylce	88	4	growth	growth	NN
cord-326960-9phlylce	88	5	do	do	VBP
cord-326960-9phlylce	88	6	not	not	RB
cord-326960-9phlylce	88	7	need	need	VB
cord-326960-9phlylce	88	8	to	to	TO
cord-326960-9phlylce	88	9	be	be	VB
cord-326960-9phlylce	88	10	made	make	VBN
cord-326960-9phlylce	88	11	,	,	,
cord-326960-9phlylce	88	12	the	the	DT
cord-326960-9phlylce	88	13	antigen	antigen	NN
cord-326960-9phlylce	88	14	can	can	MD
cord-326960-9phlylce	88	15	be	be	VB
cord-326960-9phlylce	88	16	an	an	DT
cord-326960-9phlylce	88	17	exact	exact	JJ
cord-326960-9phlylce	88	18	sequence	sequence	NN
cord-326960-9phlylce	88	19	match	match	NN
cord-326960-9phlylce	88	20	to	to	IN
cord-326960-9phlylce	88	21	the	the	DT
cord-326960-9phlylce	88	22	human	human	JJ
cord-326960-9phlylce	88	23	pathogen	pathogen	NN
cord-326960-9phlylce	88	24	.	.	.
cord-326960-9phlylce	89	1	This	this	DT
cord-326960-9phlylce	89	2	has	have	VBZ
cord-326960-9phlylce	89	3	the	the	DT
cord-326960-9phlylce	89	4	potential	potential	NN
cord-326960-9phlylce	89	5	to	to	TO
cord-326960-9phlylce	89	6	solve	solve	VB
cord-326960-9phlylce	89	7	the	the	DT
cord-326960-9phlylce	89	8	ineffectiveness	ineffectiveness	NN
cord-326960-9phlylce	89	9	observed	observe	VBN
cord-326960-9phlylce	89	10	for	for	IN
cord-326960-9phlylce	89	11	some	some	DT
cord-326960-9phlylce	89	12	egg	egg	NN
cord-326960-9phlylce	89	13	-	-	HYPH
cord-326960-9phlylce	89	14	adapted	adapt	VBN
cord-326960-9phlylce	89	15	vaccines	vaccine	NNS
cord-326960-9phlylce	89	16	as	as	IN
cord-326960-9phlylce	89	17	was	be	VBD
cord-326960-9phlylce	89	18	described	describe	VBN
cord-326960-9phlylce	89	19	by	by	IN
cord-326960-9phlylce	89	20	Skowronski	Skowronski	NNP
cord-326960-9phlylce	89	21	et	et	NNP
cord-326960-9phlylce	89	22	al	al	NNP
cord-326960-9phlylce	89	23	.	.	.
cord-326960-9phlylce	90	1	(	(	-LRB-
cord-326960-9phlylce	90	2	2014	2014	CD
cord-326960-9phlylce	90	3	)	)	-RRB-
cord-326960-9phlylce	90	4	[	[	-LRB-
cord-326960-9phlylce	90	5	19	19	CD
cord-326960-9phlylce	90	6	]	]	-RRB-
cord-326960-9phlylce	90	7	.	.	.
cord-326960-9phlylce	91	1	Moreover	moreover	RB
cord-326960-9phlylce	91	2	,	,	,
cord-326960-9phlylce	91	3	specific	specific	JJ
cord-326960-9phlylce	91	4	point	point	NN
cord-326960-9phlylce	91	5	mutations	mutation	NNS
cord-326960-9phlylce	91	6	can	can	MD
cord-326960-9phlylce	91	7	be	be	VB
cord-326960-9phlylce	91	8	introduced	introduce	VBN
cord-326960-9phlylce	91	9	to	to	TO
cord-326960-9phlylce	91	10	enhance	enhance	VB
cord-326960-9phlylce	91	11	features	feature	NNS
cord-326960-9phlylce	91	12	such	such	JJ
cord-326960-9phlylce	91	13	as	as	IN
cord-326960-9phlylce	91	14	stability	stability	NN
cord-326960-9phlylce	91	15	.	.	.
cord-326960-9phlylce	92	1	For	for	IN
cord-326960-9phlylce	92	2	example	example	NN
cord-326960-9phlylce	92	3	,	,	,
cord-326960-9phlylce	92	4	it	-PRON-	PRP
cord-326960-9phlylce	92	5	has	have	VBZ
cord-326960-9phlylce	92	6	recently	recently	RB
cord-326960-9phlylce	92	7	been	be	VBN
cord-326960-9phlylce	92	8	reported	report	VBN
cord-326960-9phlylce	92	9	that	that	IN
cord-326960-9phlylce	92	10	purified	purify	VBN
cord-326960-9phlylce	92	11	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	92	12	protein	protein	NN
cord-326960-9phlylce	92	13	,	,	,
cord-326960-9phlylce	92	14	the	the	DT
cord-326960-9phlylce	92	15	protective	protective	JJ
cord-326960-9phlylce	92	16	antigen	antigen	NN
cord-326960-9phlylce	92	17	in	in	IN
cord-326960-9phlylce	92	18	influenza	influenza	NN
cord-326960-9phlylce	92	19	vaccines	vaccine	NNS
cord-326960-9phlylce	92	20	,	,	,
cord-326960-9phlylce	92	21	appears	appear	VBZ
cord-326960-9phlylce	92	22	unstable	unstable	JJ
cord-326960-9phlylce	92	23	in	in	IN
cord-326960-9phlylce	92	24	the	the	DT
cord-326960-9phlylce	92	25	SRID	SRID	NNP
cord-326960-9phlylce	92	26	potency	potency	NN
cord-326960-9phlylce	92	27	assay	assay	NN
cord-326960-9phlylce	92	28	due	due	IN
cord-326960-9phlylce	92	29	to	to	IN
cord-326960-9phlylce	92	30	crosslinking	crosslinking	NN
cord-326960-9phlylce	92	31	of	of	IN
cord-326960-9phlylce	92	32	specific	specific	JJ
cord-326960-9phlylce	92	33	cysteine	cysteine	NN
cord-326960-9phlylce	92	34	residues	residue	NNS
cord-326960-9phlylce	92	35	in	in	IN
cord-326960-9phlylce	92	36	the	the	DT
cord-326960-9phlylce	92	37	protein	protein	NN
cord-326960-9phlylce	92	38	[	[	-LRB-
cord-326960-9phlylce	92	39	20	20	CD
cord-326960-9phlylce	92	40	]	]	-RRB-
cord-326960-9phlylce	92	41	.	.	.
cord-326960-9phlylce	93	1	By	by	IN
cord-326960-9phlylce	93	2	mutating	mutate	VBG
cord-326960-9phlylce	93	3	these	these	DT
cord-326960-9phlylce	93	4	cysteine	cysteine	NN
cord-326960-9phlylce	93	5	residues	residue	NNS
cord-326960-9phlylce	93	6	to	to	IN
cord-326960-9phlylce	93	7	non	non	JJ
cord-326960-9phlylce	93	8	-	-	JJ
cord-326960-9phlylce	93	9	thiol	thiol	JJ
cord-326960-9phlylce	93	10	residues	residue	NNS
cord-326960-9phlylce	93	11	,	,	,
cord-326960-9phlylce	93	12	it	-PRON-	PRP
cord-326960-9phlylce	93	13	was	be	VBD
cord-326960-9phlylce	93	14	possible	possible	JJ
cord-326960-9phlylce	93	15	to	to	TO
cord-326960-9phlylce	93	16	prevent	prevent	VB
cord-326960-9phlylce	93	17	cross	cross	NN
cord-326960-9phlylce	93	18	-	-	JJ
cord-326960-9phlylce	93	19	linking	link	VBG
cord-326960-9phlylce	93	20	and	and	CC
cord-326960-9phlylce	93	21	enhance	enhance	VB
cord-326960-9phlylce	93	22	stability	stability	NN
cord-326960-9phlylce	93	23	[	[	-LRB-
cord-326960-9phlylce	93	24	21	21	CD
cord-326960-9phlylce	93	25	]	]	-RRB-
cord-326960-9phlylce	93	26	.	.	.
cord-326960-9phlylce	94	1	A	a	DT
cord-326960-9phlylce	94	2	second	second	JJ
cord-326960-9phlylce	94	3	shortcoming	shortcoming	NN
cord-326960-9phlylce	94	4	with	with	IN
cord-326960-9phlylce	94	5	traditional	traditional	JJ
cord-326960-9phlylce	94	6	vaccine	vaccine	NN
cord-326960-9phlylce	94	7	manufacturing	manufacturing	NN
cord-326960-9phlylce	94	8	is	be	VBZ
cord-326960-9phlylce	94	9	process	process	NN
cord-326960-9phlylce	94	10	length	length	NN
cord-326960-9phlylce	94	11	.	.	.
cord-326960-9phlylce	95	1	Again	again	RB
cord-326960-9phlylce	95	2	,	,	,
cord-326960-9phlylce	95	3	influenza	influenza	NN
cord-326960-9phlylce	95	4	serves	serve	VBZ
cord-326960-9phlylce	95	5	as	as	IN
cord-326960-9phlylce	95	6	a	a	DT
cord-326960-9phlylce	95	7	good	good	JJ
cord-326960-9phlylce	95	8	example	example	NN
cord-326960-9phlylce	95	9	.	.	.
cord-326960-9phlylce	96	1	Influenza	influenza	NN
cord-326960-9phlylce	96	2	epidemics	epidemic	NNS
cord-326960-9phlylce	96	3	occur	occur	VBP
cord-326960-9phlylce	96	4	every	every	DT
cord-326960-9phlylce	96	5	year	year	NN
cord-326960-9phlylce	96	6	and	and	CC
cord-326960-9phlylce	96	7	annual	annual	JJ
cord-326960-9phlylce	96	8	influenza	influenza	NN
cord-326960-9phlylce	96	9	vaccination	vaccination	NN
cord-326960-9phlylce	96	10	is	be	VBZ
cord-326960-9phlylce	96	11	recommended	recommend	VBN
cord-326960-9phlylce	96	12	by	by	IN
cord-326960-9phlylce	96	13	the	the	DT
cord-326960-9phlylce	96	14	Centers	Centers	NNPS
cord-326960-9phlylce	96	15	for	for	IN
cord-326960-9phlylce	96	16	Disease	Disease	NNP
cord-326960-9phlylce	96	17	Control	Control	NNP
cord-326960-9phlylce	96	18	and	and	CC
cord-326960-9phlylce	96	19	Prevention	Prevention	NNP
cord-326960-9phlylce	96	20	[	[	-LRB-
cord-326960-9phlylce	96	21	22	22	CD
cord-326960-9phlylce	96	22	]	]	-RRB-
cord-326960-9phlylce	96	23	.	.	.
cord-326960-9phlylce	97	1	In	in	IN
cord-326960-9phlylce	97	2	addition	addition	NN
cord-326960-9phlylce	97	3	,	,	,
cord-326960-9phlylce	97	4	pandemic	pandemic	NN
cord-326960-9phlylce	97	5	outbreaks	outbreak	NNS
cord-326960-9phlylce	97	6	occur	occur	VBP
cord-326960-9phlylce	97	7	occasionally	occasionally	RB
cord-326960-9phlylce	97	8	,	,	,
cord-326960-9phlylce	97	9	the	the	DT
cord-326960-9phlylce	97	10	most	most	RBS
cord-326960-9phlylce	97	11	recent	recent	JJ
cord-326960-9phlylce	97	12	of	of	IN
cord-326960-9phlylce	97	13	which	which	WDT
cord-326960-9phlylce	97	14	was	be	VBD
cord-326960-9phlylce	97	15	the	the	DT
cord-326960-9phlylce	97	16	2009	2009	CD
cord-326960-9phlylce	97	17	H1N1	H1N1	NNP
cord-326960-9phlylce	97	18	swine	swine	NN
cord-326960-9phlylce	97	19	flu	flu	NN
cord-326960-9phlylce	97	20	(	(	-LRB-
cord-326960-9phlylce	97	21	A	A	NNP
cord-326960-9phlylce	97	22	/	/	SYM
cord-326960-9phlylce	97	23	California/07/2009	california/07/2009	NN
cord-326960-9phlylce	97	24	)	)	-RRB-
cord-326960-9phlylce	98	1	[	[	-LRB-
cord-326960-9phlylce	98	2	23	23	CD
cord-326960-9phlylce	98	3	,	,	,
cord-326960-9phlylce	98	4	24	24	CD
cord-326960-9phlylce	98	5	]	]	-RRB-
cord-326960-9phlylce	98	6	.	.	.
cord-326960-9phlylce	99	1	Timeliness	timeliness	NN
cord-326960-9phlylce	99	2	of	of	IN
cord-326960-9phlylce	99	3	vaccine	vaccine	NN
cord-326960-9phlylce	99	4	manufacture	manufacture	NN
cord-326960-9phlylce	99	5	is	be	VBZ
cord-326960-9phlylce	99	6	critical	critical	JJ
cord-326960-9phlylce	99	7	to	to	TO
cord-326960-9phlylce	99	8	ensure	ensure	VB
cord-326960-9phlylce	99	9	that	that	IN
cord-326960-9phlylce	99	10	adequate	adequate	JJ
cord-326960-9phlylce	99	11	vaccine	vaccine	NN
cord-326960-9phlylce	99	12	supply	supply	NN
cord-326960-9phlylce	99	13	is	be	VBZ
cord-326960-9phlylce	99	14	available	available	JJ
cord-326960-9phlylce	99	15	.	.	.
cord-326960-9phlylce	100	1	Egg	egg	NN
cord-326960-9phlylce	100	2	-	-	HYPH
cord-326960-9phlylce	100	3	based	base	VBN
cord-326960-9phlylce	100	4	influenza	influenza	NN
cord-326960-9phlylce	100	5	vaccine	vaccine	NN
cord-326960-9phlylce	100	6	manufacturing	manufacturing	NN
cord-326960-9phlylce	100	7	takes	take	VBZ
cord-326960-9phlylce	100	8	on	on	RP
cord-326960-9phlylce	100	9	average	average	JJ
cord-326960-9phlylce	100	10	about	about	RB
cord-326960-9phlylce	100	11	six	six	CD
cord-326960-9phlylce	100	12	months	month	NNS
cord-326960-9phlylce	100	13	,	,	,
cord-326960-9phlylce	100	14	as	as	IN
cord-326960-9phlylce	100	15	the	the	DT
cord-326960-9phlylce	100	16	process	process	NN
cord-326960-9phlylce	100	17	of	of	IN
cord-326960-9phlylce	100	18	creating	create	VBG
cord-326960-9phlylce	100	19	a	a	DT
cord-326960-9phlylce	100	20	high	high	RB
cord-326960-9phlylce	100	21	-	-	HYPH
cord-326960-9phlylce	100	22	producing	produce	VBG
cord-326960-9phlylce	100	23	,	,	,
cord-326960-9phlylce	100	24	egg	egg	NN
cord-326960-9phlylce	100	25	-	-	HYPH
cord-326960-9phlylce	100	26	adapted	adapt	VBN
cord-326960-9phlylce	100	27	seed	seed	NN
cord-326960-9phlylce	100	28	virus	virus	NN
cord-326960-9phlylce	100	29	is	be	VBZ
cord-326960-9phlylce	100	30	slow	slow	JJ
cord-326960-9phlylce	100	31	[	[	-LRB-
cord-326960-9phlylce	100	32	17	17	CD
cord-326960-9phlylce	100	33	]	]	-RRB-
cord-326960-9phlylce	100	34	.	.	.
cord-326960-9phlylce	101	1	This	this	DT
cord-326960-9phlylce	101	2	means	mean	VBZ
cord-326960-9phlylce	101	3	that	that	IN
cord-326960-9phlylce	101	4	manufacturing	manufacturing	NN
cord-326960-9phlylce	101	5	of	of	IN
cord-326960-9phlylce	101	6	seasonal	seasonal	JJ
cord-326960-9phlylce	101	7	influenza	influenza	NN
cord-326960-9phlylce	101	8	vaccines	vaccine	NNS
cord-326960-9phlylce	101	9	must	must	MD
cord-326960-9phlylce	101	10	begin	begin	VB
cord-326960-9phlylce	101	11	the	the	DT
cord-326960-9phlylce	101	12	winter	winter	NN
cord-326960-9phlylce	101	13	prior	prior	RB
cord-326960-9phlylce	101	14	to	to	IN
cord-326960-9phlylce	101	15	an	an	DT
cord-326960-9phlylce	101	16	epidemic	epidemic	NN
cord-326960-9phlylce	101	17	,	,	,
cord-326960-9phlylce	101	18	before	before	IN
cord-326960-9phlylce	101	19	that	that	DT
cord-326960-9phlylce	101	20	season	season	NN
cord-326960-9phlylce	101	21	's	's	POS
cord-326960-9phlylce	101	22	strain	strain	NN
cord-326960-9phlylce	101	23	prevalence	prevalence	NN
cord-326960-9phlylce	101	24	is	be	VBZ
cord-326960-9phlylce	101	25	definitively	definitively	RB
cord-326960-9phlylce	101	26	known	know	VBN
cord-326960-9phlylce	101	27	,	,	,
cord-326960-9phlylce	101	28	to	to	TO
cord-326960-9phlylce	101	29	guarantee	guarantee	VB
cord-326960-9phlylce	101	30	adequate	adequate	JJ
cord-326960-9phlylce	101	31	supply	supply	NN
cord-326960-9phlylce	101	32	,	,	,
cord-326960-9phlylce	101	33	and	and	CC
cord-326960-9phlylce	101	34	this	this	DT
cord-326960-9phlylce	101	35	has	have	VBZ
cord-326960-9phlylce	101	36	resulted	result	VBN
cord-326960-9phlylce	101	37	in	in	IN
cord-326960-9phlylce	101	38	seasons	season	NNS
cord-326960-9phlylce	101	39	where	where	WRB
cord-326960-9phlylce	101	40	the	the	DT
cord-326960-9phlylce	101	41	available	available	JJ
cord-326960-9phlylce	101	42	influenza	influenza	NN
cord-326960-9phlylce	101	43	vaccines	vaccine	NNS
cord-326960-9phlylce	101	44	have	have	VBP
cord-326960-9phlylce	101	45	not	not	RB
cord-326960-9phlylce	101	46	matched	match	VBN
cord-326960-9phlylce	101	47	the	the	DT
cord-326960-9phlylce	101	48	circulating	circulate	VBG
cord-326960-9phlylce	101	49	influenza	influenza	NN
cord-326960-9phlylce	101	50	strains	strain	NNS
cord-326960-9phlylce	101	51	[	[	-LRB-
cord-326960-9phlylce	101	52	25	25	CD
cord-326960-9phlylce	101	53	,	,	,
cord-326960-9phlylce	101	54	26	26	CD
cord-326960-9phlylce	101	55	]	]	-RRB-
cord-326960-9phlylce	101	56	.	.	.
cord-326960-9phlylce	102	1	Moreover	moreover	RB
cord-326960-9phlylce	102	2	,	,	,
cord-326960-9phlylce	102	3	the	the	DT
cord-326960-9phlylce	102	4	President	President	NNP
cord-326960-9phlylce	102	5	's	's	POS
cord-326960-9phlylce	102	6	Council	Council	NNP
cord-326960-9phlylce	102	7	of	of	IN
cord-326960-9phlylce	102	8	Advisors	Advisors	NNPS
cord-326960-9phlylce	102	9	on	on	IN
cord-326960-9phlylce	102	10	Science	Science	NNP
cord-326960-9phlylce	102	11	and	and	CC
cord-326960-9phlylce	102	12	Technology	Technology	NNP
cord-326960-9phlylce	102	13	(	(	-LRB-
cord-326960-9phlylce	102	14	PCAST	PCAST	NNP
cord-326960-9phlylce	102	15	)	)	-RRB-
cord-326960-9phlylce	102	16	reported	report	VBD
cord-326960-9phlylce	102	17	that	that	IN
cord-326960-9phlylce	102	18	pandemic	pandemic	NN
cord-326960-9phlylce	102	19	influenza	influenza	NN
cord-326960-9phlylce	102	20	vaccine	vaccine	NN
cord-326960-9phlylce	102	21	in	in	IN
cord-326960-9phlylce	102	22	2009	2009	CD
cord-326960-9phlylce	102	23	was	be	VBD
cord-326960-9phlylce	102	24	not	not	RB
cord-326960-9phlylce	102	25	readily	readily	RB
cord-326960-9phlylce	102	26	available	available	JJ
cord-326960-9phlylce	102	27	until	until	IN
cord-326960-9phlylce	102	28	after	after	IN
cord-326960-9phlylce	102	29	the	the	DT
cord-326960-9phlylce	102	30	pandemic	pandemic	NN
cord-326960-9phlylce	102	31	peaked	peak	VBD
cord-326960-9phlylce	102	32	,	,	,
cord-326960-9phlylce	102	33	a	a	DT
cord-326960-9phlylce	102	34	major	major	JJ
cord-326960-9phlylce	102	35	concern	concern	NN
cord-326960-9phlylce	102	36	for	for	IN
cord-326960-9phlylce	102	37	public	public	JJ
cord-326960-9phlylce	102	38	health	health	NN
cord-326960-9phlylce	102	39	and	and	CC
cord-326960-9phlylce	102	40	safety	safety	NN
cord-326960-9phlylce	102	41	(	(	-LRB-
cord-326960-9phlylce	102	42	www.whitehouse.gov/sites/default/files/microsites/ostp/	www.whitehouse.gov/sites/default/files/microsites/ostp/	NNP
cord-326960-9phlylce	102	43	PCAST-Influenza-Vaccinology-Report.pdf	PCAST-Influenza-Vaccinology-Report.pdf	NNP
cord-326960-9phlylce	102	44	)	)	-RRB-
cord-326960-9phlylce	102	45	.	.	.
cord-326960-9phlylce	103	1	PCAST	PCAST	NNP
cord-326960-9phlylce	103	2	identified	identify	VBD
cord-326960-9phlylce	103	3	recombinant	recombinant	JJ
cord-326960-9phlylce	103	4	technology	technology	NN
cord-326960-9phlylce	103	5	and	and	CC
cord-326960-9phlylce	103	6	freedom	freedom	NN
cord-326960-9phlylce	103	7	from	from	IN
cord-326960-9phlylce	103	8	virus	virus	NN
cord-326960-9phlylce	103	9	growth	growth	NN
cord-326960-9phlylce	103	10	and	and	CC
cord-326960-9phlylce	103	11	egg	egg	NN
cord-326960-9phlylce	103	12	adaptation	adaptation	NN
cord-326960-9phlylce	103	13	as	as	IN
cord-326960-9phlylce	103	14	the	the	DT
cord-326960-9phlylce	103	15	solution	solution	NN
cord-326960-9phlylce	103	16	to	to	IN
cord-326960-9phlylce	103	17	this	this	DT
cord-326960-9phlylce	103	18	problem	problem	NN
cord-326960-9phlylce	103	19	.	.	.
cord-326960-9phlylce	104	1	BEVS	bevs	NN
cord-326960-9phlylce	104	2	-	-	HYPH
cord-326960-9phlylce	104	3	derived	derive	VBN
cord-326960-9phlylce	104	4	influenza	influenza	NN
cord-326960-9phlylce	104	5	vaccines	vaccine	NNS
cord-326960-9phlylce	104	6	do	do	VBP
cord-326960-9phlylce	104	7	not	not	RB
cord-326960-9phlylce	104	8	require	require	VB
cord-326960-9phlylce	104	9	seed	seed	NN
cord-326960-9phlylce	104	10	viruses	virus	NNS
cord-326960-9phlylce	104	11	and	and	CC
cord-326960-9phlylce	104	12	can	can	MD
cord-326960-9phlylce	104	13	be	be	VB
cord-326960-9phlylce	104	14	produced	produce	VBN
cord-326960-9phlylce	104	15	in	in	IN
cord-326960-9phlylce	104	16	as	as	RB
cord-326960-9phlylce	104	17	little	little	JJ
cord-326960-9phlylce	104	18	as	as	IN
cord-326960-9phlylce	104	19	45	45	CD
cord-326960-9phlylce	104	20	days	day	NNS
cord-326960-9phlylce	104	21	[	[	-LRB-
cord-326960-9phlylce	104	22	5	5	CD
cord-326960-9phlylce	104	23	]	]	-RRB-
cord-326960-9phlylce	104	24	.	.	.
cord-326960-9phlylce	105	1	In	in	IN
cord-326960-9phlylce	105	2	addition	addition	NN
cord-326960-9phlylce	105	3	to	to	IN
cord-326960-9phlylce	105	4	specificity	specificity	NN
cord-326960-9phlylce	105	5	and	and	CC
cord-326960-9phlylce	105	6	speed	speed	NN
cord-326960-9phlylce	105	7	,	,	,
cord-326960-9phlylce	105	8	recombinant	recombinant	JJ
cord-326960-9phlylce	105	9	technology	technology	NN
cord-326960-9phlylce	105	10	offers	offer	VBZ
cord-326960-9phlylce	105	11	advantages	advantage	NNS
cord-326960-9phlylce	105	12	with	with	IN
cord-326960-9phlylce	105	13	respect	respect	NN
cord-326960-9phlylce	105	14	to	to	IN
cord-326960-9phlylce	105	15	purity	purity	NN
cord-326960-9phlylce	105	16	and	and	CC
cord-326960-9phlylce	105	17	product	product	NN
cord-326960-9phlylce	105	18	design	design	NN
cord-326960-9phlylce	105	19	.	.	.
cord-326960-9phlylce	106	1	With	with	IN
cord-326960-9phlylce	106	2	respect	respect	NN
cord-326960-9phlylce	106	3	to	to	IN
cord-326960-9phlylce	106	4	purity	purity	NN
cord-326960-9phlylce	106	5	,	,	,
cord-326960-9phlylce	106	6	recombinant	recombinant	JJ
cord-326960-9phlylce	106	7	products	product	NNS
cord-326960-9phlylce	106	8	are	be	VBP
cord-326960-9phlylce	106	9	free	free	JJ
cord-326960-9phlylce	106	10	of	of	IN
cord-326960-9phlylce	106	11	pathogens	pathogen	NNS
cord-326960-9phlylce	106	12	,	,	,
cord-326960-9phlylce	106	13	eggs	egg	NNS
cord-326960-9phlylce	106	14	and	and	CC
cord-326960-9phlylce	106	15	many	many	JJ
cord-326960-9phlylce	106	16	chemicals	chemical	NNS
cord-326960-9phlylce	106	17	(	(	-LRB-
cord-326960-9phlylce	106	18	such	such	JJ
cord-326960-9phlylce	106	19	as	as	IN
cord-326960-9phlylce	106	20	formalin	formalin	NN
cord-326960-9phlylce	106	21	and	and	CC
cord-326960-9phlylce	106	22	antibiotics	antibiotic	NNS
cord-326960-9phlylce	106	23	)	)	-RRB-
cord-326960-9phlylce	106	24	that	that	WDT
cord-326960-9phlylce	106	25	can	can	MD
cord-326960-9phlylce	106	26	be	be	VB
cord-326960-9phlylce	106	27	undesirable	undesirable	JJ
cord-326960-9phlylce	106	28	or	or	CC
cord-326960-9phlylce	106	29	allergenic	allergenic	JJ
cord-326960-9phlylce	106	30	[	[	-LRB-
cord-326960-9phlylce	106	31	27	27	CD
cord-326960-9phlylce	106	32	]	]	-RRB-
cord-326960-9phlylce	106	33	.	.	.
cord-326960-9phlylce	107	1	For	for	IN
cord-326960-9phlylce	107	2	product	product	NN
cord-326960-9phlylce	107	3	design	design	NN
cord-326960-9phlylce	107	4	,	,	,
cord-326960-9phlylce	107	5	recombinant	recombinant	JJ
cord-326960-9phlylce	107	6	techniques	technique	NNS
cord-326960-9phlylce	107	7	make	make	VBP
cord-326960-9phlylce	107	8	it	-PRON-	PRP
cord-326960-9phlylce	107	9	possible	possible	JJ
cord-326960-9phlylce	107	10	to	to	TO
cord-326960-9phlylce	107	11	engineer	engineer	VB
cord-326960-9phlylce	107	12	proteins	protein	NNS
cord-326960-9phlylce	107	13	with	with	IN
cord-326960-9phlylce	107	14	desired	desire	VBN
cord-326960-9phlylce	107	15	features	feature	NNS
cord-326960-9phlylce	107	16	,	,	,
cord-326960-9phlylce	107	17	such	such	JJ
cord-326960-9phlylce	107	18	as	as	IN
cord-326960-9phlylce	107	19	fusion	fusion	NN
cord-326960-9phlylce	107	20	proteins	protein	NNS
cord-326960-9phlylce	107	21	that	that	WDT
cord-326960-9phlylce	107	22	increase	increase	VBP
cord-326960-9phlylce	107	23	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	107	24	or	or	CC
cord-326960-9phlylce	107	25	include	include	VBP
cord-326960-9phlylce	107	26	multiple	multiple	JJ
cord-326960-9phlylce	107	27	antigens	antigen	NNS
cord-326960-9phlylce	107	28	and	and	CC
cord-326960-9phlylce	107	29	truncated	truncated	JJ
cord-326960-9phlylce	107	30	proteins	protein	NNS
cord-326960-9phlylce	107	31	with	with	IN
cord-326960-9phlylce	107	32	deleted	delete	VBN
cord-326960-9phlylce	107	33	domains	domain	NNS
cord-326960-9phlylce	107	34	to	to	TO
cord-326960-9phlylce	107	35	improve	improve	VB
cord-326960-9phlylce	107	36	yields	yield	NNS
cord-326960-9phlylce	107	37	and	and	CC
cord-326960-9phlylce	107	38	ease	ease	VB
cord-326960-9phlylce	107	39	purification	purification	NN
cord-326960-9phlylce	107	40	[	[	-LRB-
cord-326960-9phlylce	107	41	28	28	CD
cord-326960-9phlylce	107	42	]	]	-RRB-
cord-326960-9phlylce	107	43	[	[	-LRB-
cord-326960-9phlylce	107	44	29	29	CD
cord-326960-9phlylce	107	45	]	]	-RRB-
cord-326960-9phlylce	108	1	[	[	-LRB-
cord-326960-9phlylce	108	2	30	30	CD
cord-326960-9phlylce	108	3	]	]	-RRB-
cord-326960-9phlylce	108	4	[	[	-LRB-
cord-326960-9phlylce	108	5	31	31	CD
cord-326960-9phlylce	108	6	]	]	-RRB-
cord-326960-9phlylce	108	7	[	[	-LRB-
cord-326960-9phlylce	108	8	32	32	CD
cord-326960-9phlylce	108	9	]	]	-RRB-
cord-326960-9phlylce	108	10	.	.	.
cord-326960-9phlylce	109	1	One	one	CD
cord-326960-9phlylce	109	2	example	example	NN
cord-326960-9phlylce	109	3	of	of	IN
cord-326960-9phlylce	109	4	this	this	DT
cord-326960-9phlylce	109	5	application	application	NN
cord-326960-9phlylce	109	6	is	be	VBZ
cord-326960-9phlylce	109	7	the	the	DT
cord-326960-9phlylce	109	8	antigen	antigen	NN
cord-326960-9phlylce	109	9	used	use	VBN
cord-326960-9phlylce	109	10	in	in	IN
cord-326960-9phlylce	109	11	Provenge	Provenge	NNP
cord-326960-9phlylce	109	12	immunotherapy	immunotherapy	NN
cord-326960-9phlylce	109	13	.	.	.
cord-326960-9phlylce	110	1	The	the	DT
cord-326960-9phlylce	110	2	antigen	antigen	NN
cord-326960-9phlylce	110	3	is	be	VBZ
cord-326960-9phlylce	110	4	a	a	DT
cord-326960-9phlylce	110	5	fusion	fusion	NN
cord-326960-9phlylce	110	6	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	110	7	consisting	consist	VBG
cord-326960-9phlylce	110	8	of	of	IN
cord-326960-9phlylce	110	9	prostatic	prostatic	JJ
cord-326960-9phlylce	110	10	acid	acid	NN
cord-326960-9phlylce	110	11	phosphatase	phosphatase	NN
cord-326960-9phlylce	110	12	(	(	-LRB-
cord-326960-9phlylce	110	13	PAP	pap	NN
cord-326960-9phlylce	110	14	)	)	-RRB-
cord-326960-9phlylce	110	15	linked	link	VBN
cord-326960-9phlylce	110	16	to	to	IN
cord-326960-9phlylce	110	17	granulocyte	granulocyte	NN
cord-326960-9phlylce	110	18	-	-	HYPH
cord-326960-9phlylce	110	19	macrophage	macrophage	NN
cord-326960-9phlylce	110	20	colonystimulating	colonystimulating	NN
cord-326960-9phlylce	110	21	factor	factor	NN
cord-326960-9phlylce	110	22	(	(	-LRB-
cord-326960-9phlylce	110	23	GM	GM	NNP
cord-326960-9phlylce	110	24	-	-	HYPH
cord-326960-9phlylce	110	25	CSF	CSF	NNP
cord-326960-9phlylce	110	26	)	)	-RRB-
cord-326960-9phlylce	110	27	and	and	CC
cord-326960-9phlylce	110	28	is	be	VBZ
cord-326960-9phlylce	110	29	used	use	VBN
cord-326960-9phlylce	110	30	to	to	TO
cord-326960-9phlylce	110	31	stimulate	stimulate	VB
cord-326960-9phlylce	110	32	autologous	autologous	JJ
cord-326960-9phlylce	110	33	antigen	antigen	NN
cord-326960-9phlylce	110	34	presenting	present	VBG
cord-326960-9phlylce	110	35	cells	cell	NNS
cord-326960-9phlylce	110	36	[	[	-LRB-
cord-326960-9phlylce	110	37	33	33	CD
cord-326960-9phlylce	110	38	]	]	-RRB-
cord-326960-9phlylce	110	39	.	.	.
cord-326960-9phlylce	111	1	The	the	DT
cord-326960-9phlylce	111	2	GM	GM	NNP
cord-326960-9phlylce	111	3	-	-	HYPH
cord-326960-9phlylce	111	4	CSF	CSF	NNP
cord-326960-9phlylce	111	5	activates	activate	VBZ
cord-326960-9phlylce	111	6	the	the	DT
cord-326960-9phlylce	111	7	antigen	antigen	NN
cord-326960-9phlylce	111	8	presenting	present	VBG
cord-326960-9phlylce	111	9	cells	cell	NNS
cord-326960-9phlylce	111	10	and	and	CC
cord-326960-9phlylce	111	11	enhances	enhance	VBZ
cord-326960-9phlylce	111	12	cell	cell	NN
cord-326960-9phlylce	111	13	viability	viability	NN
cord-326960-9phlylce	111	14	while	while	IN
cord-326960-9phlylce	111	15	the	the	DT
cord-326960-9phlylce	111	16	PAP	pap	NN
cord-326960-9phlylce	111	17	serves	serve	VBZ
cord-326960-9phlylce	111	18	as	as	IN
cord-326960-9phlylce	111	19	the	the	DT
cord-326960-9phlylce	111	20	target	target	NN
cord-326960-9phlylce	111	21	antigen	antigen	NN
cord-326960-9phlylce	111	22	.	.	.
cord-326960-9phlylce	112	1	Another	another	DT
cord-326960-9phlylce	112	2	example	example	NN
cord-326960-9phlylce	112	3	is	be	VBZ
cord-326960-9phlylce	112	4	the	the	DT
cord-326960-9phlylce	112	5	Cervarix	Cervarix	NNP
cord-326960-9phlylce	112	6	®	®	POS
cord-326960-9phlylce	112	7	vaccine	vaccine	NN
cord-326960-9phlylce	112	8	manufactured	manufacture	VBN
cord-326960-9phlylce	112	9	by	by	IN
cord-326960-9phlylce	112	10	GlaxoSmithKline	GlaxoSmithKline	NNP
cord-326960-9phlylce	112	11	.	.	.
cord-326960-9phlylce	113	1	The	the	DT
cord-326960-9phlylce	113	2	vaccine	vaccine	NN
cord-326960-9phlylce	113	3	is	be	VBZ
cord-326960-9phlylce	113	4	a	a	DT
cord-326960-9phlylce	113	5	bivalent	bivalent	JJ
cord-326960-9phlylce	113	6	virus	virus	NN
cord-326960-9phlylce	113	7	-	-	HYPH
cord-326960-9phlylce	113	8	like	like	JJ
cord-326960-9phlylce	113	9	particle	particle	NN
cord-326960-9phlylce	113	10	(	(	-LRB-
cord-326960-9phlylce	113	11	VLP	VLP	NNP
cord-326960-9phlylce	113	12	)	)	-RRB-
cord-326960-9phlylce	113	13	comprised	comprise	VBN
cord-326960-9phlylce	113	14	of	of	IN
cord-326960-9phlylce	113	15	the	the	DT
cord-326960-9phlylce	113	16	human	human	JJ
cord-326960-9phlylce	113	17	papillomavirus	papillomavirus	NN
cord-326960-9phlylce	113	18	L1	L1	NNP
cord-326960-9phlylce	113	19	proteins	protein	NNS
cord-326960-9phlylce	113	20	(	(	-LRB-
cord-326960-9phlylce	113	21	strains	strain	NNS
cord-326960-9phlylce	113	22	16	16	CD
cord-326960-9phlylce	113	23	and	and	CC
cord-326960-9phlylce	113	24	18	18	CD
cord-326960-9phlylce	113	25	)	)	-RRB-
cord-326960-9phlylce	113	26	.	.	.
cord-326960-9phlylce	114	1	By	by	IN
cord-326960-9phlylce	114	2	expressing	express	VBG
cord-326960-9phlylce	114	3	C	c	NN
cord-326960-9phlylce	114	4	-	-	HYPH
cord-326960-9phlylce	114	5	terminally	terminally	RB
cord-326960-9phlylce	114	6	truncated	truncated	JJ
cord-326960-9phlylce	114	7	L1	l1	NN
cord-326960-9phlylce	114	8	proteins	protein	NNS
cord-326960-9phlylce	114	9	,	,	,
cord-326960-9phlylce	114	10	the	the	DT
cord-326960-9phlylce	114	11	manufacturers	manufacturer	NNS
cord-326960-9phlylce	114	12	are	be	VBP
cord-326960-9phlylce	114	13	able	able	JJ
cord-326960-9phlylce	114	14	to	to	TO
cord-326960-9phlylce	114	15	prevent	prevent	VB
cord-326960-9phlylce	114	16	intracellular	intracellular	JJ
cord-326960-9phlylce	114	17	VLP	VLP	NNP
cord-326960-9phlylce	114	18	self	self	NN
cord-326960-9phlylce	114	19	-	-	HYPH
cord-326960-9phlylce	114	20	assembly	assembly	NN
cord-326960-9phlylce	114	21	,	,	,
cord-326960-9phlylce	114	22	which	which	WDT
cord-326960-9phlylce	114	23	would	would	MD
cord-326960-9phlylce	114	24	complicate	complicate	VB
cord-326960-9phlylce	114	25	purification	purification	NN
cord-326960-9phlylce	114	26	.	.	.
cord-326960-9phlylce	115	1	Instead	instead	RB
cord-326960-9phlylce	115	2	,	,	,
cord-326960-9phlylce	115	3	the	the	DT
cord-326960-9phlylce	115	4	L1	L1	NNP
cord-326960-9phlylce	115	5	subunit	subunit	NN
cord-326960-9phlylce	115	6	proteins	protein	NNS
cord-326960-9phlylce	115	7	are	be	VBP
cord-326960-9phlylce	115	8	purified	purify	VBN
cord-326960-9phlylce	115	9	to	to	IN
cord-326960-9phlylce	115	10	a	a	DT
cord-326960-9phlylce	115	11	high	high	JJ
cord-326960-9phlylce	115	12	degree	degree	NN
cord-326960-9phlylce	115	13	and	and	CC
cord-326960-9phlylce	115	14	VLP	VLP	NNP
cord-326960-9phlylce	115	15	assembly	assembly	NN
cord-326960-9phlylce	115	16	is	be	VBZ
cord-326960-9phlylce	115	17	achieved	achieve	VBN
cord-326960-9phlylce	115	18	in	in	IN
cord-326960-9phlylce	115	19	vitro	vitro	FW
cord-326960-9phlylce	115	20	[	[	-LRB-
cord-326960-9phlylce	115	21	28	28	CD
cord-326960-9phlylce	115	22	]	]	-RRB-
cord-326960-9phlylce	115	23	.	.	.
cord-326960-9phlylce	116	1	The	the	DT
cord-326960-9phlylce	116	2	BEVS	BEVS	NNP
cord-326960-9phlylce	116	3	platform	platform	NN
cord-326960-9phlylce	116	4	has	have	VBZ
cord-326960-9phlylce	116	5	inherent	inherent	JJ
cord-326960-9phlylce	116	6	safety	safety	NN
cord-326960-9phlylce	116	7	measures	measure	NNS
cord-326960-9phlylce	116	8	built	build	VBN
cord-326960-9phlylce	116	9	in	in	IN
cord-326960-9phlylce	116	10	that	that	WDT
cord-326960-9phlylce	116	11	are	be	VBP
cord-326960-9phlylce	116	12	attractive	attractive	JJ
cord-326960-9phlylce	116	13	from	from	IN
cord-326960-9phlylce	116	14	a	a	DT
cord-326960-9phlylce	116	15	regulatory	regulatory	JJ
cord-326960-9phlylce	116	16	perspective	perspective	NN
cord-326960-9phlylce	116	17	.	.	.
cord-326960-9phlylce	117	1	Baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	117	2	have	have	VBP
cord-326960-9phlylce	117	3	a	a	DT
cord-326960-9phlylce	117	4	narrow	narrow	JJ
cord-326960-9phlylce	117	5	host	host	NN
cord-326960-9phlylce	117	6	range	range	NN
cord-326960-9phlylce	117	7	restricted	restrict	VBN
cord-326960-9phlylce	117	8	to	to	IN
cord-326960-9phlylce	117	9	specific	specific	JJ
cord-326960-9phlylce	117	10	insects	insect	NNS
cord-326960-9phlylce	117	11	and	and	CC
cord-326960-9phlylce	117	12	are	be	VBP
cord-326960-9phlylce	117	13	considered	consider	VBN
cord-326960-9phlylce	117	14	safe	safe	JJ
cord-326960-9phlylce	117	15	to	to	TO
cord-326960-9phlylce	117	16	use	use	VB
cord-326960-9phlylce	117	17	as	as	IN
cord-326960-9phlylce	117	18	biological	biological	JJ
cord-326960-9phlylce	117	19	pesticides	pesticide	NNS
cord-326960-9phlylce	117	20	with	with	IN
cord-326960-9phlylce	117	21	no	no	DT
cord-326960-9phlylce	117	22	negative	negative	JJ
cord-326960-9phlylce	117	23	impact	impact	NN
cord-326960-9phlylce	117	24	on	on	IN
cord-326960-9phlylce	117	25	plants	plant	NNS
cord-326960-9phlylce	117	26	,	,	,
cord-326960-9phlylce	117	27	mammals	mammal	NNS
cord-326960-9phlylce	117	28	,	,	,
cord-326960-9phlylce	117	29	birds	bird	NNS
cord-326960-9phlylce	117	30	,	,	,
cord-326960-9phlylce	117	31	fish	fish	NN
cord-326960-9phlylce	117	32	or	or	CC
cord-326960-9phlylce	117	33	non	non	JJ
cord-326960-9phlylce	117	34	-	-	JJ
cord-326960-9phlylce	117	35	target	target	JJ
cord-326960-9phlylce	117	36	insects	insect	NNS
cord-326960-9phlylce	117	37	[	[	-LRB-
cord-326960-9phlylce	117	38	9	9	CD
cord-326960-9phlylce	117	39	]	]	-RRB-
cord-326960-9phlylce	117	40	.	.	.
cord-326960-9phlylce	118	1	People	People	NNS
cord-326960-9phlylce	118	2	are	be	VBP
cord-326960-9phlylce	118	3	exposed	expose	VBN
cord-326960-9phlylce	118	4	to	to	IN
cord-326960-9phlylce	118	5	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	118	6	daily	daily	RB
cord-326960-9phlylce	118	7	by	by	IN
cord-326960-9phlylce	118	8	consuming	consume	VBG
cord-326960-9phlylce	118	9	fresh	fresh	JJ
cord-326960-9phlylce	118	10	vegetables	vegetable	NNS
cord-326960-9phlylce	118	11	.	.	.
cord-326960-9phlylce	119	1	For	for	IN
cord-326960-9phlylce	119	2	instance	instance	NN
cord-326960-9phlylce	119	3	,	,	,
cord-326960-9phlylce	119	4	a	a	DT
cord-326960-9phlylce	119	5	serving	serving	NN
cord-326960-9phlylce	119	6	of	of	IN
cord-326960-9phlylce	119	7	coleslaw	coleslaw	NN
cord-326960-9phlylce	119	8	may	may	MD
cord-326960-9phlylce	119	9	contain	contain	VB
cord-326960-9phlylce	119	10	hundreds	hundred	NNS
cord-326960-9phlylce	119	11	of	of	IN
cord-326960-9phlylce	119	12	millions	million	NNS
cord-326960-9phlylce	119	13	of	of	IN
cord-326960-9phlylce	119	14	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	119	15	[	[	-LRB-
cord-326960-9phlylce	119	16	34	34	CD
cord-326960-9phlylce	119	17	]	]	-RRB-
cord-326960-9phlylce	119	18	.	.	.
cord-326960-9phlylce	120	1	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	120	2	vectors	vector	NNS
cord-326960-9phlylce	120	3	have	have	VBP
cord-326960-9phlylce	120	4	also	also	RB
cord-326960-9phlylce	120	5	been	be	VBN
cord-326960-9phlylce	120	6	explored	explore	VBN
cord-326960-9phlylce	120	7	as	as	IN
cord-326960-9phlylce	120	8	gene	gene	NN
cord-326960-9phlylce	120	9	therapy	therapy	NN
cord-326960-9phlylce	120	10	vectors	vector	NNS
cord-326960-9phlylce	120	11	.	.	.
cord-326960-9phlylce	121	1	These	these	DT
cord-326960-9phlylce	121	2	studies	study	NNS
cord-326960-9phlylce	121	3	have	have	VBP
cord-326960-9phlylce	121	4	demonstrated	demonstrate	VBN
cord-326960-9phlylce	121	5	that	that	IN
cord-326960-9phlylce	121	6	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	121	7	can	can	MD
cord-326960-9phlylce	121	8	not	not	RB
cord-326960-9phlylce	121	9	repli	repli	VB
cord-326960-9phlylce	121	10	-	-	HYPH
cord-326960-9phlylce	121	11	cate	cate	NNP
cord-326960-9phlylce	121	12	in	in	IN
cord-326960-9phlylce	121	13	mammalian	mammalian	JJ
cord-326960-9phlylce	121	14	cells	cell	NNS
cord-326960-9phlylce	121	15	and	and	CC
cord-326960-9phlylce	121	16	can	can	MD
cord-326960-9phlylce	121	17	not	not	RB
cord-326960-9phlylce	121	18	express	express	VB
cord-326960-9phlylce	121	19	a	a	DT
cord-326960-9phlylce	121	20	gene	gene	NN
cord-326960-9phlylce	121	21	cassette	cassette	NN
cord-326960-9phlylce	121	22	unless	unless	IN
cord-326960-9phlylce	121	23	it	-PRON-	PRP
cord-326960-9phlylce	121	24	is	be	VBZ
cord-326960-9phlylce	121	25	driven	drive	VBN
cord-326960-9phlylce	121	26	by	by	IN
cord-326960-9phlylce	121	27	a	a	DT
cord-326960-9phlylce	121	28	mammalian	mammalian	JJ
cord-326960-9phlylce	121	29	promoter	promoter	NN
cord-326960-9phlylce	121	30	[	[	-LRB-
cord-326960-9phlylce	121	31	9	9	CD
cord-326960-9phlylce	121	32	,	,	,
cord-326960-9phlylce	121	33	[	[	-LRB-
cord-326960-9phlylce	121	34	35	35	CD
cord-326960-9phlylce	121	35	]	]	-RRB-
cord-326960-9phlylce	121	36	[	[	-LRB-
cord-326960-9phlylce	121	37	36	36	CD
cord-326960-9phlylce	121	38	]	]	-RRB-
cord-326960-9phlylce	121	39	[	[	-LRB-
cord-326960-9phlylce	121	40	37	37	CD
cord-326960-9phlylce	121	41	]	]	-RRB-
cord-326960-9phlylce	121	42	[	[	-LRB-
cord-326960-9phlylce	121	43	38	38	CD
cord-326960-9phlylce	121	44	]	]	-RRB-
cord-326960-9phlylce	121	45	.	.	.
cord-326960-9phlylce	122	1	A	a	DT
cord-326960-9phlylce	122	2	major	major	JJ
cord-326960-9phlylce	122	3	consideration	consideration	NN
cord-326960-9phlylce	122	4	for	for	IN
cord-326960-9phlylce	122	5	regulatory	regulatory	JJ
cord-326960-9phlylce	122	6	agencies	agency	NNS
cord-326960-9phlylce	122	7	when	when	WRB
cord-326960-9phlylce	122	8	evaluating	evaluate	VBG
cord-326960-9phlylce	122	9	a	a	DT
cord-326960-9phlylce	122	10	novel	novel	JJ
cord-326960-9phlylce	122	11	cell	cell	NN
cord-326960-9phlylce	122	12	substrate	substrate	NN
cord-326960-9phlylce	122	13	is	be	VBZ
cord-326960-9phlylce	122	14	the	the	DT
cord-326960-9phlylce	122	15	potential	potential	NN
cord-326960-9phlylce	122	16	to	to	TO
cord-326960-9phlylce	122	17	harbor	harbor	VB
cord-326960-9phlylce	122	18	adventitious	adventitious	JJ
cord-326960-9phlylce	122	19	agents	agent	NNS
cord-326960-9phlylce	122	20	that	that	WDT
cord-326960-9phlylce	122	21	could	could	MD
cord-326960-9phlylce	122	22	threaten	threaten	VB
cord-326960-9phlylce	122	23	patient	patient	JJ
cord-326960-9phlylce	122	24	safety	safety	NN
cord-326960-9phlylce	122	25	.	.	.
cord-326960-9phlylce	123	1	There	there	EX
cord-326960-9phlylce	123	2	are	be	VBP
cord-326960-9phlylce	123	3	very	very	RB
cord-326960-9phlylce	123	4	few	few	JJ
cord-326960-9phlylce	123	5	adventitious	adventitious	JJ
cord-326960-9phlylce	123	6	agents	agent	NNS
cord-326960-9phlylce	123	7	that	that	WDT
cord-326960-9phlylce	123	8	can	can	MD
cord-326960-9phlylce	123	9	replicate	replicate	VB
cord-326960-9phlylce	123	10	in	in	IN
cord-326960-9phlylce	123	11	both	both	DT
cord-326960-9phlylce	123	12	insect	insect	NN
cord-326960-9phlylce	123	13	and	and	CC
cord-326960-9phlylce	123	14	mammalian	mammalian	JJ
cord-326960-9phlylce	123	15	cells	cell	NNS
cord-326960-9phlylce	123	16	.	.	.
cord-326960-9phlylce	124	1	A	a	DT
cord-326960-9phlylce	124	2	notable	notable	JJ
cord-326960-9phlylce	124	3	exception	exception	NN
cord-326960-9phlylce	124	4	is	be	VBZ
cord-326960-9phlylce	124	5	arboviruses	arbovirus	NNS
cord-326960-9phlylce	124	6	that	that	WDT
cord-326960-9phlylce	124	7	can	can	MD
cord-326960-9phlylce	124	8	be	be	VB
cord-326960-9phlylce	124	9	transmitted	transmit	VBN
cord-326960-9phlylce	124	10	to	to	IN
cord-326960-9phlylce	124	11	humans	human	NNS
cord-326960-9phlylce	124	12	via	via	IN
cord-326960-9phlylce	124	13	insect	insect	NN
cord-326960-9phlylce	124	14	bites	bite	NNS
cord-326960-9phlylce	124	15	and	and	CC
cord-326960-9phlylce	124	16	can	can	MD
cord-326960-9phlylce	124	17	cause	cause	VB
cord-326960-9phlylce	124	18	complications	complication	NNS
cord-326960-9phlylce	124	19	such	such	JJ
cord-326960-9phlylce	124	20	as	as	IN
cord-326960-9phlylce	124	21	encephalitis	encephalitis	JJ
cord-326960-9phlylce	124	22	and	and	CC
cord-326960-9phlylce	124	23	hemorrhagic	hemorrhagic	JJ
cord-326960-9phlylce	124	24	fever	fever	NN
cord-326960-9phlylce	124	25	[	[	-LRB-
cord-326960-9phlylce	124	26	39	39	CD
cord-326960-9phlylce	124	27	]	]	-RRB-
cord-326960-9phlylce	124	28	.	.	.
cord-326960-9phlylce	125	1	To	to	TO
cord-326960-9phlylce	125	2	mitigate	mitigate	VB
cord-326960-9phlylce	125	3	this	this	DT
cord-326960-9phlylce	125	4	risk	risk	NN
cord-326960-9phlylce	125	5	,	,	,
cord-326960-9phlylce	125	6	cells	cell	NNS
cord-326960-9phlylce	125	7	from	from	IN
cord-326960-9phlylce	125	8	non	non	JJ
cord-326960-9phlylce	125	9	-	-	JJ
cord-326960-9phlylce	125	10	biting	biting	JJ
cord-326960-9phlylce	125	11	insects	insect	NNS
cord-326960-9phlylce	125	12	such	such	JJ
cord-326960-9phlylce	125	13	as	as	IN
cord-326960-9phlylce	125	14	the	the	DT
cord-326960-9phlylce	125	15	fall	fall	NN
cord-326960-9phlylce	125	16	armyworm	armyworm	NNP
cord-326960-9phlylce	125	17	and	and	CC
cord-326960-9phlylce	125	18	cabbage	cabbage	NN
cord-326960-9phlylce	125	19	looper	looper	NN
cord-326960-9phlylce	125	20	have	have	VBP
cord-326960-9phlylce	125	21	been	be	VBN
cord-326960-9phlylce	125	22	used	use	VBN
cord-326960-9phlylce	125	23	with	with	IN
cord-326960-9phlylce	125	24	BEVS	BEVS	NNP
cord-326960-9phlylce	125	25	as	as	IN
cord-326960-9phlylce	125	26	noted	note	VBN
cord-326960-9phlylce	125	27	above	above	RB
cord-326960-9phlylce	125	28	.	.	.
cord-326960-9phlylce	126	1	Nonetheless	nonetheless	RB
cord-326960-9phlylce	126	2	,	,	,
cord-326960-9phlylce	126	3	adventitious	adventitious	JJ
cord-326960-9phlylce	126	4	agents	agent	NNS
cord-326960-9phlylce	126	5	have	have	VBP
cord-326960-9phlylce	126	6	been	be	VBN
cord-326960-9phlylce	126	7	detected	detect	VBN
cord-326960-9phlylce	126	8	in	in	IN
cord-326960-9phlylce	126	9	some	some	DT
cord-326960-9phlylce	126	10	insect	insect	NN
cord-326960-9phlylce	126	11	cell	cell	NN
cord-326960-9phlylce	126	12	lines	line	NNS
cord-326960-9phlylce	126	13	.	.	.
cord-326960-9phlylce	127	1	For	for	IN
cord-326960-9phlylce	127	2	instance	instance	NN
cord-326960-9phlylce	127	3	,	,	,
cord-326960-9phlylce	127	4	the	the	DT
cord-326960-9phlylce	127	5	Trichoplusia	Trichoplusia	NNP
cord-326960-9phlylce	127	6	ni	ni	NNP
cord-326960-9phlylce	127	7	High	High	NNP
cord-326960-9phlylce	127	8	Five	five	CD
cord-326960-9phlylce	127	9	cell	cell	NN
cord-326960-9phlylce	127	10	line	line	NN
cord-326960-9phlylce	127	11	,	,	,
cord-326960-9phlylce	127	12	BTI	BTI	NNP
cord-326960-9phlylce	127	13	-	-	HYPH
cord-326960-9phlylce	127	14	TN-5B1	TN-5B1	NNP
cord-326960-9phlylce	127	15	-	-	HYPH
cord-326960-9phlylce	127	16	4	4	CD
cord-326960-9phlylce	127	17	,	,	,
cord-326960-9phlylce	127	18	used	use	VBN
cord-326960-9phlylce	127	19	to	to	TO
cord-326960-9phlylce	127	20	make	make	VB
cord-326960-9phlylce	127	21	Cervarix	Cervarix	NNP
cord-326960-9phlylce	127	22	®	®	POS
cord-326960-9phlylce	127	23	,	,	,
cord-326960-9phlylce	127	24	was	be	VBD
cord-326960-9phlylce	127	25	found	find	VBN
cord-326960-9phlylce	127	26	to	to	TO
cord-326960-9phlylce	127	27	be	be	VB
cord-326960-9phlylce	127	28	latently	latently	RB
cord-326960-9phlylce	127	29	infected	infect	VBN
cord-326960-9phlylce	127	30	with	with	IN
cord-326960-9phlylce	127	31	an	an	DT
cord-326960-9phlylce	127	32	Alphanodavirus	Alphanodavirus	NNP
cord-326960-9phlylce	127	33	that	that	WDT
cord-326960-9phlylce	127	34	was	be	VBD
cord-326960-9phlylce	127	35	induced	induce	VBN
cord-326960-9phlylce	127	36	by	by	IN
cord-326960-9phlylce	127	37	recombinant	recombinant	JJ
cord-326960-9phlylce	127	38	baculovirus	baculovirus	NN
cord-326960-9phlylce	127	39	infection	infection	NN
cord-326960-9phlylce	127	40	[	[	-LRB-
cord-326960-9phlylce	127	41	40	40	CD
cord-326960-9phlylce	127	42	]	]	-RRB-
cord-326960-9phlylce	127	43	.	.	.
cord-326960-9phlylce	128	1	In	in	IN
cord-326960-9phlylce	128	2	addition	addition	NN
cord-326960-9phlylce	128	3	,	,	,
cord-326960-9phlylce	128	4	other	other	JJ
cord-326960-9phlylce	128	5	insect	insect	NN
cord-326960-9phlylce	128	6	cell	cell	NN
cord-326960-9phlylce	128	7	lines	line	NNS
cord-326960-9phlylce	128	8	,	,	,
cord-326960-9phlylce	128	9	such	such	JJ
cord-326960-9phlylce	128	10	as	as	IN
cord-326960-9phlylce	128	11	those	those	DT
cord-326960-9phlylce	128	12	generated	generate	VBN
cord-326960-9phlylce	128	13	from	from	IN
cord-326960-9phlylce	128	14	Drosophila	Drosophila	NNP
cord-326960-9phlylce	128	15	melanogaster	melanogaster	NN
cord-326960-9phlylce	128	16	,	,	,
cord-326960-9phlylce	128	17	have	have	VBP
cord-326960-9phlylce	128	18	been	be	VBN
cord-326960-9phlylce	128	19	shown	show	VBN
cord-326960-9phlylce	128	20	to	to	TO
cord-326960-9phlylce	128	21	harbor	harbor	VB
cord-326960-9phlylce	128	22	innate	innate	JJ
cord-326960-9phlylce	128	23	retroelements	retroelement	NNS
cord-326960-9phlylce	128	24	derived	derive	VBN
cord-326960-9phlylce	128	25	from	from	IN
cord-326960-9phlylce	128	26	retroviruses	retrovirus	NNS
cord-326960-9phlylce	128	27	that	that	WDT
cord-326960-9phlylce	128	28	could	could	MD
cord-326960-9phlylce	128	29	potentially	potentially	RB
cord-326960-9phlylce	128	30	be	be	VB
cord-326960-9phlylce	128	31	infectious	infectious	JJ
cord-326960-9phlylce	128	32	[	[	-LRB-
cord-326960-9phlylce	128	33	41	41	CD
cord-326960-9phlylce	128	34	]	]	-RRB-
cord-326960-9phlylce	128	35	.	.	.
cord-326960-9phlylce	129	1	More	more	RBR
cord-326960-9phlylce	129	2	recently	recently	RB
cord-326960-9phlylce	129	3	,	,	,
cord-326960-9phlylce	129	4	a	a	DT
cord-326960-9phlylce	129	5	possible	possible	JJ
cord-326960-9phlylce	129	6	insect	insect	NN
cord-326960-9phlylce	129	7	-	-	HYPH
cord-326960-9phlylce	129	8	specific	specific	JJ
cord-326960-9phlylce	129	9	virus	virus	NN
cord-326960-9phlylce	129	10	Sf	Sf	NNP
cord-326960-9phlylce	129	11	-	-	HYPH
cord-326960-9phlylce	129	12	rhabdovirus	rhabdovirus	NNP
cord-326960-9phlylce	129	13	was	be	VBD
cord-326960-9phlylce	129	14	identified	identify	VBN
cord-326960-9phlylce	129	15	in	in	IN
cord-326960-9phlylce	129	16	Spodoptera	Spodoptera	NNP
cord-326960-9phlylce	129	17	frugiperda	frugiperda	NN
cord-326960-9phlylce	129	18	cells	cell	NNS
cord-326960-9phlylce	129	19	[	[	-LRB-
cord-326960-9phlylce	129	20	42	42	CD
cord-326960-9phlylce	129	21	]	]	-RRB-
cord-326960-9phlylce	129	22	.	.	.
cord-326960-9phlylce	130	1	Although	although	IN
cord-326960-9phlylce	130	2	studies	study	NNS
cord-326960-9phlylce	130	3	showed	show	VBD
cord-326960-9phlylce	130	4	that	that	IN
cord-326960-9phlylce	130	5	this	this	DT
cord-326960-9phlylce	130	6	virus	virus	NN
cord-326960-9phlylce	130	7	could	could	MD
cord-326960-9phlylce	130	8	not	not	RB
cord-326960-9phlylce	130	9	enter	enter	VB
cord-326960-9phlylce	130	10	or	or	CC
cord-326960-9phlylce	130	11	replicate	replicate	VB
cord-326960-9phlylce	130	12	in	in	IN
cord-326960-9phlylce	130	13	human	human	JJ
cord-326960-9phlylce	130	14	cell	cell	NN
cord-326960-9phlylce	130	15	lines	line	NNS
cord-326960-9phlylce	130	16	and	and	CC
cord-326960-9phlylce	130	17	,	,	,
cord-326960-9phlylce	130	18	therefore	therefore	RB
cord-326960-9phlylce	130	19	,	,	,
cord-326960-9phlylce	130	20	is	be	VBZ
cord-326960-9phlylce	130	21	unlikely	unlikely	JJ
cord-326960-9phlylce	130	22	to	to	TO
cord-326960-9phlylce	130	23	be	be	VB
cord-326960-9phlylce	130	24	a	a	DT
cord-326960-9phlylce	130	25	risk	risk	NN
cord-326960-9phlylce	130	26	,	,	,
cord-326960-9phlylce	130	27	novel	novel	JJ
cord-326960-9phlylce	130	28	cell	cell	NN
cord-326960-9phlylce	130	29	lines	line	NNS
cord-326960-9phlylce	130	30	will	will	MD
cord-326960-9phlylce	130	31	most	most	RBS
cord-326960-9phlylce	130	32	likely	likely	RB
cord-326960-9phlylce	130	33	need	need	VB
cord-326960-9phlylce	130	34	to	to	TO
cord-326960-9phlylce	130	35	be	be	VB
cord-326960-9phlylce	130	36	characterized	characterize	VBN
cord-326960-9phlylce	130	37	and	and	CC
cord-326960-9phlylce	130	38	monitored	monitor	VBN
cord-326960-9phlylce	130	39	for	for	IN
cord-326960-9phlylce	130	40	the	the	DT
cord-326960-9phlylce	130	41	presence	presence	NN
cord-326960-9phlylce	130	42	of	of	IN
cord-326960-9phlylce	130	43	this	this	DT
cord-326960-9phlylce	130	44	virus	virus	NN
cord-326960-9phlylce	130	45	as	as	IN
cord-326960-9phlylce	130	46	they	-PRON-	PRP
cord-326960-9phlylce	130	47	are	be	VBP
cord-326960-9phlylce	130	48	for	for	IN
cord-326960-9phlylce	130	49	nodaviruses	nodaviruse	NNS
cord-326960-9phlylce	130	50	,	,	,
cord-326960-9phlylce	130	51	retroviruses	retrovirus	NNS
cord-326960-9phlylce	130	52	and	and	CC
cord-326960-9phlylce	130	53	others	other	NNS
cord-326960-9phlylce	130	54	.	.	.
cord-326960-9phlylce	131	1	In	in	IN
cord-326960-9phlylce	131	2	general	general	JJ
cord-326960-9phlylce	131	3	,	,	,
cord-326960-9phlylce	131	4	because	because	IN
cord-326960-9phlylce	131	5	adventitious	adventitious	JJ
cord-326960-9phlylce	131	6	agents	agent	NNS
cord-326960-9phlylce	131	7	are	be	VBP
cord-326960-9phlylce	131	8	a	a	DT
cord-326960-9phlylce	131	9	potential	potential	JJ
cord-326960-9phlylce	131	10	threat	threat	NN
cord-326960-9phlylce	131	11	,	,	,
cord-326960-9phlylce	131	12	cell	cell	NN
cord-326960-9phlylce	131	13	substrates	substrate	NNS
cord-326960-9phlylce	131	14	of	of	IN
cord-326960-9phlylce	131	15	all	all	DT
cord-326960-9phlylce	131	16	origins	origin	NNS
cord-326960-9phlylce	131	17	(	(	-LRB-
cord-326960-9phlylce	131	18	including	include	VBG
cord-326960-9phlylce	131	19	insect	insect	NN
cord-326960-9phlylce	131	20	and	and	CC
cord-326960-9phlylce	131	21	others	other	NNS
cord-326960-9phlylce	131	22	)	)	-RRB-
cord-326960-9phlylce	131	23	must	must	MD
cord-326960-9phlylce	131	24	be	be	VB
cord-326960-9phlylce	131	25	thoroughly	thoroughly	RB
cord-326960-9phlylce	131	26	tested	test	VBN
cord-326960-9phlylce	131	27	for	for	IN
cord-326960-9phlylce	131	28	the	the	DT
cord-326960-9phlylce	131	29	presence	presence	NN
cord-326960-9phlylce	131	30	and	and	CC
cord-326960-9phlylce	131	31	infectivity	infectivity	NN
cord-326960-9phlylce	131	32	of	of	IN
cord-326960-9phlylce	131	33	such	such	JJ
cord-326960-9phlylce	131	34	agents	agent	NNS
cord-326960-9phlylce	131	35	before	before	IN
cord-326960-9phlylce	131	36	they	-PRON-	PRP
cord-326960-9phlylce	131	37	are	be	VBP
cord-326960-9phlylce	131	38	allowed	allow	VBN
cord-326960-9phlylce	131	39	by	by	IN
cord-326960-9phlylce	131	40	regulatory	regulatory	JJ
cord-326960-9phlylce	131	41	agencies	agency	NNS
cord-326960-9phlylce	131	42	for	for	IN
cord-326960-9phlylce	131	43	manufacturing	manufacture	VBG
cord-326960-9phlylce	131	44	use	use	NN
cord-326960-9phlylce	131	45	.	.	.
cord-326960-9phlylce	132	1	In	in	IN
cord-326960-9phlylce	132	2	addition	addition	NN
cord-326960-9phlylce	132	3	to	to	IN
cord-326960-9phlylce	132	4	the	the	DT
cord-326960-9phlylce	132	5	safety	safety	NN
cord-326960-9phlylce	132	6	considerations	consideration	NNS
cord-326960-9phlylce	132	7	just	just	RB
cord-326960-9phlylce	132	8	discussed	discuss	VBD
cord-326960-9phlylce	132	9	,	,	,
cord-326960-9phlylce	132	10	there	there	EX
cord-326960-9phlylce	132	11	are	be	VBP
cord-326960-9phlylce	132	12	two	two	CD
cord-326960-9phlylce	132	13	important	important	JJ
cord-326960-9phlylce	132	14	regulatory	regulatory	JJ
cord-326960-9phlylce	132	15	features	feature	NNS
cord-326960-9phlylce	132	16	associated	associate	VBN
cord-326960-9phlylce	132	17	with	with	IN
cord-326960-9phlylce	132	18	the	the	DT
cord-326960-9phlylce	132	19	BEVS	BEVS	NNP
cord-326960-9phlylce	132	20	platform	platform	NN
cord-326960-9phlylce	132	21	that	that	WDT
cord-326960-9phlylce	132	22	should	should	MD
cord-326960-9phlylce	132	23	be	be	VB
cord-326960-9phlylce	132	24	considered	consider	VBN
cord-326960-9phlylce	132	25	.	.	.
cord-326960-9phlylce	133	1	The	the	DT
cord-326960-9phlylce	133	2	first	first	JJ
cord-326960-9phlylce	133	3	is	be	VBZ
cord-326960-9phlylce	133	4	that	that	IN
cord-326960-9phlylce	133	5	BEVS	BEVS	NNP
cord-326960-9phlylce	133	6	is	be	VBZ
cord-326960-9phlylce	133	7	a	a	DT
cord-326960-9phlylce	133	8	transient	transient	JJ
cord-326960-9phlylce	133	9	protein	protein	NN
cord-326960-9phlylce	133	10	expression	expression	NN
cord-326960-9phlylce	133	11	system	system	NN
cord-326960-9phlylce	133	12	;	;	:
cord-326960-9phlylce	133	13	the	the	DT
cord-326960-9phlylce	133	14	recombinant	recombinant	JJ
cord-326960-9phlylce	133	15	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	133	16	used	use	VBN
cord-326960-9phlylce	133	17	vary	vary	VBP
cord-326960-9phlylce	133	18	based	base	VBN
cord-326960-9phlylce	133	19	on	on	IN
cord-326960-9phlylce	133	20	their	-PRON-	PRP$
cord-326960-9phlylce	133	21	foreign	foreign	JJ
cord-326960-9phlylce	133	22	gene	gene	NN
cord-326960-9phlylce	133	23	cassettes	cassette	NNS
cord-326960-9phlylce	133	24	but	but	CC
cord-326960-9phlylce	133	25	a	a	DT
cord-326960-9phlylce	133	26	single	single	JJ
cord-326960-9phlylce	133	27	cell	cell	NN
cord-326960-9phlylce	133	28	line	line	NN
cord-326960-9phlylce	133	29	can	can	MD
cord-326960-9phlylce	133	30	be	be	VB
cord-326960-9phlylce	133	31	used	use	VBN
cord-326960-9phlylce	133	32	for	for	IN
cord-326960-9phlylce	133	33	the	the	DT
cord-326960-9phlylce	133	34	expression	expression	NN
cord-326960-9phlylce	133	35	of	of	IN
cord-326960-9phlylce	133	36	all	all	DT
cord-326960-9phlylce	133	37	proteins	protein	NNS
cord-326960-9phlylce	133	38	(	(	-LRB-
cord-326960-9phlylce	133	39	Fig	Fig	NNP
cord-326960-9phlylce	133	40	.	.	.
cord-326960-9phlylce	133	41	1	1	CD
cord-326960-9phlylce	133	42	)	)	-RRB-
cord-326960-9phlylce	133	43	.	.	.
cord-326960-9phlylce	134	1	Qualifying	qualify	VBG
cord-326960-9phlylce	134	2	a	a	DT
cord-326960-9phlylce	134	3	cell	cell	NN
cord-326960-9phlylce	134	4	line	line	NN
cord-326960-9phlylce	134	5	is	be	VBZ
cord-326960-9phlylce	134	6	no	no	DT
cord-326960-9phlylce	134	7	small	small	JJ
cord-326960-9phlylce	134	8	feat	feat	NN
cord-326960-9phlylce	134	9	.	.	.
cord-326960-9phlylce	135	1	It	-PRON-	PRP
cord-326960-9phlylce	135	2	can	can	MD
cord-326960-9phlylce	135	3	take	take	VB
cord-326960-9phlylce	135	4	years	year	NNS
cord-326960-9phlylce	135	5	of	of	IN
cord-326960-9phlylce	135	6	work	work	NN
cord-326960-9phlylce	135	7	to	to	TO
cord-326960-9phlylce	135	8	adequately	adequately	RB
cord-326960-9phlylce	135	9	ensure	ensure	VB
cord-326960-9phlylce	135	10	purity	purity	NN
cord-326960-9phlylce	135	11	and	and	CC
cord-326960-9phlylce	135	12	safety	safety	NN
cord-326960-9phlylce	135	13	in	in	IN
cord-326960-9phlylce	135	14	addition	addition	NN
cord-326960-9phlylce	135	15	to	to	IN
cord-326960-9phlylce	135	16	high	high	JJ
cord-326960-9phlylce	135	17	productivity	productivity	NN
cord-326960-9phlylce	135	18	.	.	.
cord-326960-9phlylce	136	1	Stable	stable	JJ
cord-326960-9phlylce	136	2	cell	cell	NN
cord-326960-9phlylce	136	3	lines	line	NNS
cord-326960-9phlylce	136	4	have	have	VBP
cord-326960-9phlylce	136	5	to	to	TO
cord-326960-9phlylce	136	6	be	be	VB
cord-326960-9phlylce	136	7	independently	independently	RB
cord-326960-9phlylce	136	8	qualified	qualify	VBN
cord-326960-9phlylce	136	9	each	each	DT
cord-326960-9phlylce	136	10	time	time	NN
cord-326960-9phlylce	136	11	their	-PRON-	PRP$
cord-326960-9phlylce	136	12	genetic	genetic	JJ
cord-326960-9phlylce	136	13	composition	composition	NN
cord-326960-9phlylce	136	14	changes	change	NNS
cord-326960-9phlylce	136	15	[	[	-LRB-
cord-326960-9phlylce	136	16	43	43	CD
cord-326960-9phlylce	136	17	]	]	-RRB-
cord-326960-9phlylce	136	18	.	.	.
cord-326960-9phlylce	137	1	In	in	IN
cord-326960-9phlylce	137	2	contrast	contrast	NN
cord-326960-9phlylce	137	3	,	,	,
cord-326960-9phlylce	137	4	cell	cell	NN
cord-326960-9phlylce	137	5	lines	line	NNS
cord-326960-9phlylce	137	6	used	use	VBN
cord-326960-9phlylce	137	7	with	with	IN
cord-326960-9phlylce	137	8	BEVS	BEVS	NNP
cord-326960-9phlylce	137	9	and	and	CC
cord-326960-9phlylce	137	10	other	other	JJ
cord-326960-9phlylce	137	11	transient	transient	JJ
cord-326960-9phlylce	137	12	expression	expression	NN
cord-326960-9phlylce	137	13	systems	system	NNS
cord-326960-9phlylce	137	14	remain	remain	VBP
cord-326960-9phlylce	137	15	constant	constant	JJ
cord-326960-9phlylce	137	16	and	and	CC
cord-326960-9phlylce	137	17	,	,	,
cord-326960-9phlylce	137	18	consequently	consequently	RB
cord-326960-9phlylce	137	19	,	,	,
cord-326960-9phlylce	137	20	need	need	VBP
cord-326960-9phlylce	137	21	to	to	TO
cord-326960-9phlylce	137	22	be	be	VB
cord-326960-9phlylce	137	23	qualified	qualified	JJ
cord-326960-9phlylce	137	24	just	just	RB
cord-326960-9phlylce	137	25	once	once	RB
cord-326960-9phlylce	137	26	.	.	.
cord-326960-9phlylce	138	1	A	a	DT
cord-326960-9phlylce	138	2	second	second	JJ
cord-326960-9phlylce	138	3	feature	feature	NN
cord-326960-9phlylce	138	4	is	be	VBZ
cord-326960-9phlylce	138	5	the	the	DT
cord-326960-9phlylce	138	6	growing	grow	VBG
cord-326960-9phlylce	138	7	number	number	NN
cord-326960-9phlylce	138	8	of	of	IN
cord-326960-9phlylce	138	9	BEVSderived	bevsderive	VBN
cord-326960-9phlylce	138	10	products	product	NNS
cord-326960-9phlylce	138	11	that	that	WDT
cord-326960-9phlylce	138	12	have	have	VBP
cord-326960-9phlylce	138	13	been	be	VBN
cord-326960-9phlylce	138	14	approved	approve	VBN
cord-326960-9phlylce	138	15	by	by	IN
cord-326960-9phlylce	138	16	regulatory	regulatory	JJ
cord-326960-9phlylce	138	17	agencies	agency	NNS
cord-326960-9phlylce	138	18	worldwide	worldwide	RB
cord-326960-9phlylce	138	19	(	(	-LRB-
cord-326960-9phlylce	138	20	Table	table	NN
cord-326960-9phlylce	138	21	1	1	CD
cord-326960-9phlylce	138	22	)	)	-RRB-
cord-326960-9phlylce	138	23	.	.	.
cord-326960-9phlylce	139	1	As	as	IN
cord-326960-9phlylce	139	2	is	be	VBZ
cord-326960-9phlylce	139	3	the	the	DT
cord-326960-9phlylce	139	4	case	case	NN
cord-326960-9phlylce	139	5	for	for	IN
cord-326960-9phlylce	139	6	all	all	DT
cord-326960-9phlylce	139	7	technologies	technology	NNS
cord-326960-9phlylce	139	8	,	,	,
cord-326960-9phlylce	139	9	prior	prior	JJ
cord-326960-9phlylce	139	10	regulatory	regulatory	JJ
cord-326960-9phlylce	139	11	approvals	approval	NNS
cord-326960-9phlylce	139	12	remove	remove	VBP
cord-326960-9phlylce	139	13	barriers	barrier	NNS
cord-326960-9phlylce	139	14	for	for	IN
cord-326960-9phlylce	139	15	future	future	JJ
cord-326960-9phlylce	139	16	product	product	NN
cord-326960-9phlylce	139	17	approvals	approval	NNS
cord-326960-9phlylce	139	18	.	.	.
cord-326960-9phlylce	140	1	The	the	DT
cord-326960-9phlylce	140	2	technology	technology	NN
cord-326960-9phlylce	140	3	becomes	become	VBZ
cord-326960-9phlylce	140	4	more	more	RBR
cord-326960-9phlylce	140	5	mainstream	mainstream	JJ
cord-326960-9phlylce	140	6	and	and	CC
cord-326960-9phlylce	140	7	less	less	JJR
cord-326960-9phlylce	140	8	novel	novel	JJ
cord-326960-9phlylce	140	9	with	with	IN
cord-326960-9phlylce	140	10	each	each	DT
cord-326960-9phlylce	140	11	approval	approval	NN
cord-326960-9phlylce	140	12	,	,	,
cord-326960-9phlylce	140	13	and	and	CC
cord-326960-9phlylce	140	14	the	the	DT
cord-326960-9phlylce	140	15	safety	safety	NN
cord-326960-9phlylce	140	16	database	database	NN
cord-326960-9phlylce	140	17	of	of	IN
cord-326960-9phlylce	140	18	patients	patient	NNS
cord-326960-9phlylce	140	19	that	that	WDT
cord-326960-9phlylce	140	20	are	be	VBP
cord-326960-9phlylce	140	21	administered	administer	VBN
cord-326960-9phlylce	140	22	products	product	NNS
cord-326960-9phlylce	140	23	without	without	IN
cord-326960-9phlylce	140	24	complication	complication	NN
cord-326960-9phlylce	140	25	continues	continue	VBZ
cord-326960-9phlylce	140	26	to	to	TO
cord-326960-9phlylce	140	27	grow	grow	VB
cord-326960-9phlylce	140	28	.	.	.
cord-326960-9phlylce	141	1	Nine	nine	CD
cord-326960-9phlylce	141	2	BEVSderived	bevsderive	VBN
cord-326960-9phlylce	141	3	products	product	NNS
cord-326960-9phlylce	141	4	have	have	VBP
cord-326960-9phlylce	141	5	been	be	VBN
cord-326960-9phlylce	141	6	licensed	license	VBN
cord-326960-9phlylce	141	7	,	,	,
cord-326960-9phlylce	141	8	providing	provide	VBG
cord-326960-9phlylce	141	9	regulators	regulator	NNS
cord-326960-9phlylce	141	10	confidence	confidence	NN
cord-326960-9phlylce	141	11	with	with	IN
cord-326960-9phlylce	141	12	the	the	DT
cord-326960-9phlylce	141	13	platform	platform	NN
cord-326960-9phlylce	141	14	.	.	.
cord-326960-9phlylce	142	1	The	the	DT
cord-326960-9phlylce	142	2	following	follow	VBG
cord-326960-9phlylce	142	3	characteristics	characteristic	NNS
cord-326960-9phlylce	142	4	make	make	VBP
cord-326960-9phlylce	142	5	the	the	DT
cord-326960-9phlylce	142	6	BEVS	BEVS	NNP
cord-326960-9phlylce	142	7	platform	platform	NN
cord-326960-9phlylce	142	8	appealing	appeal	VBG
cord-326960-9phlylce	142	9	for	for	IN
cord-326960-9phlylce	142	10	commercial	commercial	JJ
cord-326960-9phlylce	142	11	manufacturing	manufacturing	NN
cord-326960-9phlylce	142	12	:	:	:
cord-326960-9phlylce	142	13	scalability	scalability	NN
cord-326960-9phlylce	142	14	,	,	,
cord-326960-9phlylce	142	15	biosafety	biosafety	NN
cord-326960-9phlylce	142	16	,	,	,
cord-326960-9phlylce	142	17	flexibility	flexibility	NN
cord-326960-9phlylce	142	18	and	and	CC
cord-326960-9phlylce	142	19	existing	exist	VBG
cord-326960-9phlylce	142	20	manufacturing	manufacturing	NN
cord-326960-9phlylce	142	21	capacity	capacity	NN
cord-326960-9phlylce	142	22	.	.	.
cord-326960-9phlylce	143	1	Insect	insect	NN
cord-326960-9phlylce	143	2	cells	cell	NNS
cord-326960-9phlylce	143	3	are	be	VBP
cord-326960-9phlylce	143	4	grown	grow	VBN
cord-326960-9phlylce	143	5	in	in	IN
cord-326960-9phlylce	143	6	suspension	suspension	NN
cord-326960-9phlylce	143	7	,	,	,
cord-326960-9phlylce	143	8	so	so	CC
cord-326960-9phlylce	143	9	if	if	IN
cord-326960-9phlylce	143	10	the	the	DT
cord-326960-9phlylce	143	11	cells	cell	NNS
cord-326960-9phlylce	143	12	and	and	CC
cord-326960-9phlylce	143	13	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	143	14	have	have	VBP
cord-326960-9phlylce	143	15	been	be	VBN
cord-326960-9phlylce	143	16	optimized	optimize	VBN
cord-326960-9phlylce	143	17	for	for	IN
cord-326960-9phlylce	143	18	large	large	JJ
cord-326960-9phlylce	143	19	scale	scale	NN
cord-326960-9phlylce	143	20	and	and	CC
cord-326960-9phlylce	143	21	multiple	multiple	JJ
cord-326960-9phlylce	143	22	passages	passage	NNS
cord-326960-9phlylce	143	23	,	,	,
cord-326960-9phlylce	143	24	the	the	DT
cord-326960-9phlylce	143	25	culture	culture	NN
cord-326960-9phlylce	143	26	size	size	NN
cord-326960-9phlylce	143	27	is	be	VBZ
cord-326960-9phlylce	143	28	only	only	RB
cord-326960-9phlylce	143	29	limited	limit	VBN
cord-326960-9phlylce	143	30	by	by	IN
cord-326960-9phlylce	143	31	the	the	DT
cord-326960-9phlylce	143	32	size	size	NN
cord-326960-9phlylce	143	33	of	of	IN
cord-326960-9phlylce	143	34	the	the	DT
cord-326960-9phlylce	143	35	bioreactor	bioreactor	NN
cord-326960-9phlylce	143	36	.	.	.
cord-326960-9phlylce	144	1	For	for	IN
cord-326960-9phlylce	144	2	example	example	NN
cord-326960-9phlylce	144	3	,	,	,
cord-326960-9phlylce	144	4	expresSF+	expressf+	NN
cord-326960-9phlylce	144	5	cells	cell	NNS
cord-326960-9phlylce	144	6	have	have	VBP
cord-326960-9phlylce	144	7	been	be	VBN
cord-326960-9phlylce	144	8	used	use	VBN
cord-326960-9phlylce	144	9	to	to	TO
cord-326960-9phlylce	144	10	produce	produce	VB
cord-326960-9phlylce	144	11	recombinant	recombinant	JJ
cord-326960-9phlylce	144	12	proteins	protein	NNS
cord-326960-9phlylce	144	13	at	at	IN
cord-326960-9phlylce	144	14	scales	scale	NNS
cord-326960-9phlylce	144	15	ranging	range	VBG
cord-326960-9phlylce	144	16	from	from	IN
cord-326960-9phlylce	144	17	two	two	CD
cord-326960-9phlylce	144	18	to	to	TO
cord-326960-9phlylce	144	19	21	21	CD
cord-326960-9phlylce	144	20	000	000	CD
cord-326960-9phlylce	144	21	L	l	NN
cord-326960-9phlylce	144	22	[	[	-LRB-
cord-326960-9phlylce	144	23	44	44	CD
cord-326960-9phlylce	144	24	]	]	-RRB-
cord-326960-9phlylce	144	25	.	.	.
cord-326960-9phlylce	145	1	The	the	DT
cord-326960-9phlylce	145	2	cost	cost	NN
cord-326960-9phlylce	145	3	of	of	IN
cord-326960-9phlylce	145	4	goods	good	NNS
cord-326960-9phlylce	145	5	for	for	IN
cord-326960-9phlylce	145	6	BEVS	bevs	NN
cord-326960-9phlylce	145	7	production	production	NN
cord-326960-9phlylce	145	8	is	be	VBZ
cord-326960-9phlylce	145	9	largely	largely	RB
cord-326960-9phlylce	145	10	dependent	dependent	JJ
cord-326960-9phlylce	145	11	on	on	IN
cord-326960-9phlylce	145	12	capital	capital	NN
cord-326960-9phlylce	145	13	costs	cost	NNS
cord-326960-9phlylce	145	14	and	and	CC
cord-326960-9phlylce	145	15	yields	yield	NNS
cord-326960-9phlylce	145	16	.	.	.
cord-326960-9phlylce	146	1	As	as	IN
cord-326960-9phlylce	146	2	discussed	discuss	VBN
cord-326960-9phlylce	146	3	by	by	IN
cord-326960-9phlylce	146	4	Cox	Cox	NNP
cord-326960-9phlylce	146	5	(	(	-LRB-
cord-326960-9phlylce	146	6	2012	2012	CD
cord-326960-9phlylce	146	7	)	)	-RRB-
cord-326960-9phlylce	146	8	,	,	,
cord-326960-9phlylce	146	9	vast	vast	JJ
cord-326960-9phlylce	146	10	global	global	JJ
cord-326960-9phlylce	146	11	bioreactor	bioreactor	NN
cord-326960-9phlylce	146	12	capacity	capacity	NN
cord-326960-9phlylce	146	13	(	(	-LRB-
cord-326960-9phlylce	146	14	~500	~500	NFP
cord-326960-9phlylce	146	15	000	000	CD
cord-326960-9phlylce	146	16	L	l	NN
cord-326960-9phlylce	146	17	)	)	-RRB-
cord-326960-9phlylce	146	18	already	already	RB
cord-326960-9phlylce	146	19	exists	exist	VBZ
cord-326960-9phlylce	146	20	and	and	CC
cord-326960-9phlylce	146	21	presents	present	VBZ
cord-326960-9phlylce	146	22	the	the	DT
cord-326960-9phlylce	146	23	opportunity	opportunity	NN
cord-326960-9phlylce	146	24	to	to	TO
cord-326960-9phlylce	146	25	minimize	minimize	VB
cord-326960-9phlylce	146	26	the	the	DT
cord-326960-9phlylce	146	27	investment	investment	NN
cord-326960-9phlylce	146	28	needed	need	VBN
cord-326960-9phlylce	146	29	to	to	TO
cord-326960-9phlylce	146	30	establish	establish	VB
cord-326960-9phlylce	146	31	BEVS	BEVS	NNP
cord-326960-9phlylce	146	32	manufacturing	manufacturing	NN
cord-326960-9phlylce	146	33	facilities	facility	NNS
cord-326960-9phlylce	146	34	[	[	-LRB-
cord-326960-9phlylce	146	35	1	1	CD
cord-326960-9phlylce	146	36	]	]	-RRB-
cord-326960-9phlylce	146	37	.	.	.
cord-326960-9phlylce	147	1	Moreover	moreover	RB
cord-326960-9phlylce	147	2	,	,	,
cord-326960-9phlylce	147	3	opportunities	opportunity	NNS
cord-326960-9phlylce	147	4	for	for	IN
cord-326960-9phlylce	147	5	yield	yield	NN
cord-326960-9phlylce	147	6	improvements	improvement	NNS
cord-326960-9phlylce	147	7	are	be	VBP
cord-326960-9phlylce	147	8	abundant	abundant	JJ
cord-326960-9phlylce	147	9	and	and	CC
cord-326960-9phlylce	147	10	include	include	VBP
cord-326960-9phlylce	147	11	genetic	genetic	JJ
cord-326960-9phlylce	147	12	and	and	CC
cord-326960-9phlylce	147	13	fermentation	fermentation	NN
cord-326960-9phlylce	147	14	-	-	HYPH
cord-326960-9phlylce	147	15	based	base	VBN
cord-326960-9phlylce	147	16	approaches	approach	NNS
cord-326960-9phlylce	147	17	;	;	:
cord-326960-9phlylce	147	18	these	these	DT
cord-326960-9phlylce	147	19	are	be	VBP
cord-326960-9phlylce	147	20	described	describe	VBN
cord-326960-9phlylce	147	21	elsewhere	elsewhere	RB
cord-326960-9phlylce	147	22	[	[	-LRB-
cord-326960-9phlylce	147	23	1	1	CD
cord-326960-9phlylce	147	24	]	]	-RRB-
cord-326960-9phlylce	147	25	.	.	.
cord-326960-9phlylce	148	1	Unlike	unlike	IN
cord-326960-9phlylce	148	2	some	some	DT
cord-326960-9phlylce	148	3	other	other	JJ
cord-326960-9phlylce	148	4	production	production	NN
cord-326960-9phlylce	148	5	facilities	facility	NNS
cord-326960-9phlylce	148	6	,	,	,
cord-326960-9phlylce	148	7	BEVS	BEVS	NNP
cord-326960-9phlylce	148	8	facilities	facility	NNS
cord-326960-9phlylce	148	9	can	can	MD
cord-326960-9phlylce	148	10	be	be	VB
cord-326960-9phlylce	148	11	multi	multi	JJ
cord-326960-9phlylce	148	12	-	-	JJ
cord-326960-9phlylce	148	13	purpose	purpose	NN
cord-326960-9phlylce	148	14	and	and	CC
cord-326960-9phlylce	148	15	used	use	VBD
cord-326960-9phlylce	148	16	to	to	TO
cord-326960-9phlylce	148	17	produce	produce	VB
cord-326960-9phlylce	148	18	a	a	DT
cord-326960-9phlylce	148	19	variety	variety	NN
cord-326960-9phlylce	148	20	of	of	IN
cord-326960-9phlylce	148	21	BEVS	bevs	NN
cord-326960-9phlylce	148	22	-	-	HYPH
cord-326960-9phlylce	148	23	derived	derive	VBN
cord-326960-9phlylce	148	24	products	product	NNS
cord-326960-9phlylce	148	25	,	,	,
cord-326960-9phlylce	148	26	especially	especially	RB
cord-326960-9phlylce	148	27	when	when	WRB
cord-326960-9phlylce	148	28	disposable	disposable	JJ
cord-326960-9phlylce	148	29	or	or	CC
cord-326960-9phlylce	148	30	single	single	JJ
cord-326960-9phlylce	148	31	-	-	HYPH
cord-326960-9phlylce	148	32	use	use	NN
cord-326960-9phlylce	148	33	technology	technology	NN
cord-326960-9phlylce	148	34	is	be	VBZ
cord-326960-9phlylce	148	35	employed	employ	VBN
cord-326960-9phlylce	148	36	[	[	-LRB-
cord-326960-9phlylce	148	37	45	45	CD
cord-326960-9phlylce	148	38	]	]	-RRB-
cord-326960-9phlylce	148	39	.	.	.
cord-326960-9phlylce	149	1	This	this	DT
cord-326960-9phlylce	149	2	is	be	VBZ
cord-326960-9phlylce	149	3	because	because	IN
cord-326960-9phlylce	149	4	a	a	DT
cord-326960-9phlylce	149	5	single	single	JJ
cord-326960-9phlylce	149	6	cell	cell	NN
cord-326960-9phlylce	149	7	line	line	NN
cord-326960-9phlylce	149	8	can	can	MD
cord-326960-9phlylce	149	9	be	be	VB
cord-326960-9phlylce	149	10	used	use	VBN
cord-326960-9phlylce	149	11	for	for	IN
cord-326960-9phlylce	149	12	production	production	NN
cord-326960-9phlylce	149	13	of	of	IN
cord-326960-9phlylce	149	14	different	different	JJ
cord-326960-9phlylce	149	15	products	product	NNS
cord-326960-9phlylce	149	16	.	.	.
cord-326960-9phlylce	150	1	This	this	DT
cord-326960-9phlylce	150	2	feature	feature	NN
cord-326960-9phlylce	150	3	is	be	VBZ
cord-326960-9phlylce	150	4	especially	especially	RB
cord-326960-9phlylce	150	5	meaningful	meaningful	JJ
cord-326960-9phlylce	150	6	for	for	IN
cord-326960-9phlylce	150	7	regions	region	NNS
cord-326960-9phlylce	150	8	of	of	IN
cord-326960-9phlylce	150	9	the	the	DT
cord-326960-9phlylce	150	10	world	world	NN
cord-326960-9phlylce	150	11	where	where	WRB
cord-326960-9phlylce	150	12	limited	limited	JJ
cord-326960-9phlylce	150	13	manufacturing	manufacturing	NN
cord-326960-9phlylce	150	14	capacity	capacity	NN
cord-326960-9phlylce	150	15	exists	exist	VBZ
cord-326960-9phlylce	150	16	.	.	.
cord-326960-9phlylce	151	1	A	a	DT
cord-326960-9phlylce	151	2	single	single	JJ
cord-326960-9phlylce	151	3	BEVS	bevs	NN
cord-326960-9phlylce	151	4	facility	facility	NN
cord-326960-9phlylce	151	5	could	could	MD
cord-326960-9phlylce	151	6	,	,	,
cord-326960-9phlylce	151	7	for	for	IN
cord-326960-9phlylce	151	8	example	example	NN
cord-326960-9phlylce	151	9	,	,	,
cord-326960-9phlylce	151	10	be	be	VB
cord-326960-9phlylce	151	11	used	use	VBN
cord-326960-9phlylce	151	12	to	to	TO
cord-326960-9phlylce	151	13	produce	produce	VB
cord-326960-9phlylce	151	14	vaccines	vaccine	NNS
cord-326960-9phlylce	151	15	for	for	IN
cord-326960-9phlylce	151	16	diseases	disease	NNS
cord-326960-9phlylce	151	17	endemic	endemic	JJ
cord-326960-9phlylce	151	18	to	to	IN
cord-326960-9phlylce	151	19	a	a	DT
cord-326960-9phlylce	151	20	region	region	NN
cord-326960-9phlylce	151	21	and	and	CC
cord-326960-9phlylce	151	22	quickly	quickly	RB
cord-326960-9phlylce	151	23	be	be	VB
cord-326960-9phlylce	151	24	converted	convert	VBN
cord-326960-9phlylce	151	25	to	to	TO
cord-326960-9phlylce	151	26	produce	produce	VB
cord-326960-9phlylce	151	27	pandemic	pandemic	NN
cord-326960-9phlylce	151	28	influenza	influenza	NN
cord-326960-9phlylce	151	29	vaccine	vaccine	NN
cord-326960-9phlylce	151	30	in	in	IN
cord-326960-9phlylce	151	31	an	an	DT
cord-326960-9phlylce	151	32	emergency	emergency	NN
cord-326960-9phlylce	151	33	.	.	.
cord-326960-9phlylce	152	1	Finally	finally	RB
cord-326960-9phlylce	152	2	,	,	,
cord-326960-9phlylce	152	3	because	because	IN
cord-326960-9phlylce	152	4	the	the	DT
cord-326960-9phlylce	152	5	BEVS	BEVS	NNP
cord-326960-9phlylce	152	6	platform	platform	NN
cord-326960-9phlylce	152	7	does	do	VBZ
cord-326960-9phlylce	152	8	not	not	RB
cord-326960-9phlylce	152	9	require	require	VB
cord-326960-9phlylce	152	10	the	the	DT
cord-326960-9phlylce	152	11	handling	handling	NN
cord-326960-9phlylce	152	12	of	of	IN
cord-326960-9phlylce	152	13	live	live	JJ
cord-326960-9phlylce	152	14	,	,	,
cord-326960-9phlylce	152	15	potentially	potentially	RB
cord-326960-9phlylce	152	16	dangerous	dangerous	JJ
cord-326960-9phlylce	152	17	pathogens	pathogen	NNS
cord-326960-9phlylce	152	18	,	,	,
cord-326960-9phlylce	152	19	requirements	requirement	NNS
cord-326960-9phlylce	152	20	for	for	IN
cord-326960-9phlylce	152	21	biocontainment	biocontainment	NN
cord-326960-9phlylce	152	22	that	that	WDT
cord-326960-9phlylce	152	23	can	can	MD
cord-326960-9phlylce	152	24	be	be	VB
cord-326960-9phlylce	152	25	very	very	RB
cord-326960-9phlylce	152	26	costly	costly	JJ
cord-326960-9phlylce	152	27	are	be	VBP
cord-326960-9phlylce	152	28	reduced	reduce	VBN
cord-326960-9phlylce	152	29	.	.	.
cord-326960-9phlylce	153	1	The	the	DT
cord-326960-9phlylce	153	2	BEVS	BEVS	NNP
cord-326960-9phlylce	153	3	platform	platform	NN
cord-326960-9phlylce	153	4	is	be	VBZ
cord-326960-9phlylce	153	5	a	a	DT
cord-326960-9phlylce	153	6	versatile	versatile	JJ
cord-326960-9phlylce	153	7	technology	technology	NN
cord-326960-9phlylce	153	8	useful	useful	JJ
cord-326960-9phlylce	153	9	for	for	IN
cord-326960-9phlylce	153	10	the	the	DT
cord-326960-9phlylce	153	11	manufacture	manufacture	NN
cord-326960-9phlylce	153	12	of	of	IN
cord-326960-9phlylce	153	13	many	many	JJ
cord-326960-9phlylce	153	14	products	product	NNS
cord-326960-9phlylce	153	15	;	;	:
cord-326960-9phlylce	153	16	however	however	RB
cord-326960-9phlylce	153	17	,	,	,
cord-326960-9phlylce	153	18	other	other	JJ
cord-326960-9phlylce	153	19	platforms	platform	NNS
cord-326960-9phlylce	153	20	may	may	MD
cord-326960-9phlylce	153	21	be	be	VB
cord-326960-9phlylce	153	22	better	well	RBR
cord-326960-9phlylce	153	23	suited	suit	VBN
cord-326960-9phlylce	153	24	for	for	IN
cord-326960-9phlylce	153	25	the	the	DT
cord-326960-9phlylce	153	26	production	production	NN
cord-326960-9phlylce	153	27	of	of	IN
cord-326960-9phlylce	153	28	certain	certain	JJ
cord-326960-9phlylce	153	29	proteins	protein	NNS
cord-326960-9phlylce	153	30	.	.	.
cord-326960-9phlylce	154	1	For	for	IN
cord-326960-9phlylce	154	2	instance	instance	NN
cord-326960-9phlylce	154	3	,	,	,
cord-326960-9phlylce	154	4	small	small	JJ
cord-326960-9phlylce	154	5	proteins	protein	NNS
cord-326960-9phlylce	154	6	that	that	WDT
cord-326960-9phlylce	154	7	do	do	VBP
cord-326960-9phlylce	154	8	not	not	RB
cord-326960-9phlylce	154	9	require	require	VB
cord-326960-9phlylce	154	10	post	post	JJ
cord-326960-9phlylce	154	11	-	-	JJ
cord-326960-9phlylce	154	12	translational	translational	JJ
cord-326960-9phlylce	154	13	modifications	modification	NNS
cord-326960-9phlylce	154	14	are	be	VBP
cord-326960-9phlylce	154	15	best	best	RB
cord-326960-9phlylce	154	16	made	make	VBN
cord-326960-9phlylce	154	17	in	in	IN
cord-326960-9phlylce	154	18	E.	E.	NNP
cord-326960-9phlylce	154	19	coli	coli	NNS
cord-326960-9phlylce	154	20	that	that	WDT
cord-326960-9phlylce	154	21	can	can	MD
cord-326960-9phlylce	154	22	quickly	quickly	RB
cord-326960-9phlylce	154	23	generate	generate	VB
cord-326960-9phlylce	154	24	high	high	JJ
cord-326960-9phlylce	154	25	yields	yield	NNS
cord-326960-9phlylce	154	26	at	at	IN
cord-326960-9phlylce	154	27	low	low	JJ
cord-326960-9phlylce	154	28	cost	cost	NN
cord-326960-9phlylce	154	29	[	[	-LRB-
cord-326960-9phlylce	154	30	4	4	CD
cord-326960-9phlylce	154	31	]	]	-RRB-
cord-326960-9phlylce	154	32	.	.	.
cord-326960-9phlylce	155	1	Yeasts	yeast	NNS
cord-326960-9phlylce	155	2	such	such	JJ
cord-326960-9phlylce	155	3	as	as	IN
cord-326960-9phlylce	155	4	S.	S.	NNP
cord-326960-9phlylce	155	5	cerevisiae	cerevisiae	NNS
cord-326960-9phlylce	155	6	can	can	MD
cord-326960-9phlylce	155	7	also	also	RB
cord-326960-9phlylce	155	8	produce	produce	VB
cord-326960-9phlylce	155	9	high	high	JJ
cord-326960-9phlylce	155	10	yields	yield	NNS
cord-326960-9phlylce	155	11	of	of	IN
cord-326960-9phlylce	155	12	protein	protein	NN
cord-326960-9phlylce	155	13	at	at	IN
cord-326960-9phlylce	155	14	low	low	JJ
cord-326960-9phlylce	155	15	cost	cost	NN
cord-326960-9phlylce	155	16	and	and	CC
cord-326960-9phlylce	155	17	are	be	VBP
cord-326960-9phlylce	155	18	capable	capable	JJ
cord-326960-9phlylce	155	19	of	of	IN
cord-326960-9phlylce	155	20	some	some	DT
cord-326960-9phlylce	155	21	post	post	JJ
cord-326960-9phlylce	155	22	-	-	JJ
cord-326960-9phlylce	155	23	translational	translational	JJ
cord-326960-9phlylce	155	24	modifications	modification	NNS
cord-326960-9phlylce	155	25	[	[	-LRB-
cord-326960-9phlylce	155	26	4	4	CD
cord-326960-9phlylce	155	27	]	]	-RRB-
cord-326960-9phlylce	155	28	.	.	.
cord-326960-9phlylce	156	1	Insect	insect	NN
cord-326960-9phlylce	156	2	cells	cell	NNS
cord-326960-9phlylce	156	3	are	be	VBP
cord-326960-9phlylce	156	4	capable	capable	JJ
cord-326960-9phlylce	156	5	of	of	IN
cord-326960-9phlylce	156	6	many	many	JJ
cord-326960-9phlylce	156	7	post	post	JJ
cord-326960-9phlylce	156	8	-	-	JJ
cord-326960-9phlylce	156	9	translational	translational	JJ
cord-326960-9phlylce	156	10	modifications	modification	NNS
cord-326960-9phlylce	156	11	but	but	CC
cord-326960-9phlylce	156	12	proteins	protein	NNS
cord-326960-9phlylce	156	13	that	that	WDT
cord-326960-9phlylce	156	14	require	require	VBP
cord-326960-9phlylce	156	15	complex	complex	JJ
cord-326960-9phlylce	156	16	post	post	JJ
cord-326960-9phlylce	156	17	-	-	JJ
cord-326960-9phlylce	156	18	translational	translational	JJ
cord-326960-9phlylce	156	19	modifications	modification	NNS
cord-326960-9phlylce	156	20	and	and	CC
cord-326960-9phlylce	156	21	folding	folding	NN
cord-326960-9phlylce	156	22	may	may	MD
cord-326960-9phlylce	156	23	best	best	RB
cord-326960-9phlylce	156	24	be	be	VB
cord-326960-9phlylce	156	25	made	make	VBN
cord-326960-9phlylce	156	26	in	in	IN
cord-326960-9phlylce	156	27	mammalian	mammalian	JJ
cord-326960-9phlylce	156	28	expression	expression	NN
cord-326960-9phlylce	156	29	systems	system	NNS
cord-326960-9phlylce	156	30	.	.	.
cord-326960-9phlylce	157	1	For	for	IN
cord-326960-9phlylce	157	2	www.biotecvisions.com	www.biotecvisions.com	ADD
cord-326960-9phlylce	158	1	www.biotechnology-journal.com	www.biotechnology-journal.com	NNP
cord-326960-9phlylce	158	2	example	example	NN
cord-326960-9phlylce	158	3	,	,	,
cord-326960-9phlylce	158	4	the	the	DT
cord-326960-9phlylce	158	5	glycosylation	glycosylation	NN
cord-326960-9phlylce	158	6	patterns	pattern	NNS
cord-326960-9phlylce	158	7	produced	produce	VBN
cord-326960-9phlylce	158	8	by	by	IN
cord-326960-9phlylce	158	9	insect	insect	NN
cord-326960-9phlylce	158	10	and	and	CC
cord-326960-9phlylce	158	11	mammalian	mammalian	JJ
cord-326960-9phlylce	158	12	cells	cell	NNS
cord-326960-9phlylce	158	13	are	be	VBP
cord-326960-9phlylce	158	14	related	relate	VBN
cord-326960-9phlylce	158	15	,	,	,
cord-326960-9phlylce	158	16	and	and	CC
cord-326960-9phlylce	158	17	glycoproteins	glycoprotein	NNS
cord-326960-9phlylce	158	18	produced	produce	VBN
cord-326960-9phlylce	158	19	in	in	IN
cord-326960-9phlylce	158	20	insect	insect	NN
cord-326960-9phlylce	158	21	cells	cell	NNS
cord-326960-9phlylce	158	22	are	be	VBP
cord-326960-9phlylce	158	23	often	often	RB
cord-326960-9phlylce	158	24	correctly	correctly	RB
cord-326960-9phlylce	158	25	folded	fold	VBN
cord-326960-9phlylce	158	26	,	,	,
cord-326960-9phlylce	158	27	biologically	biologically	RB
cord-326960-9phlylce	158	28	active	active	JJ
cord-326960-9phlylce	158	29	and	and	CC
cord-326960-9phlylce	158	30	immunogenic	immunogenic	JJ
cord-326960-9phlylce	158	31	[	[	-LRB-
cord-326960-9phlylce	158	32	46	46	CD
cord-326960-9phlylce	158	33	]	]	-RRB-
cord-326960-9phlylce	158	34	.	.	.
cord-326960-9phlylce	159	1	However	however	RB
cord-326960-9phlylce	159	2	,	,	,
cord-326960-9phlylce	159	3	insect	insect	NN
cord-326960-9phlylce	159	4	cells	cell	NNS
cord-326960-9phlylce	159	5	generate	generate	VBP
cord-326960-9phlylce	159	6	less	less	JJR
cord-326960-9phlylce	159	7	complex	complex	JJ
cord-326960-9phlylce	159	8	N	n	CD
cord-326960-9phlylce	159	9	-	-	HYPH
cord-326960-9phlylce	159	10	glycans	glycan	NNS
cord-326960-9phlylce	159	11	than	than	IN
cord-326960-9phlylce	159	12	mammalian	mammalian	JJ
cord-326960-9phlylce	159	13	cells	cell	NNS
cord-326960-9phlylce	159	14	and	and	CC
cord-326960-9phlylce	159	15	this	this	DT
cord-326960-9phlylce	159	16	can	can	MD
cord-326960-9phlylce	159	17	negatively	negatively	RB
cord-326960-9phlylce	159	18	impact	impact	VB
cord-326960-9phlylce	159	19	biological	biological	JJ
cord-326960-9phlylce	159	20	function	function	NN
cord-326960-9phlylce	159	21	[	[	-LRB-
cord-326960-9phlylce	159	22	46	46	CD
cord-326960-9phlylce	159	23	,	,	,
cord-326960-9phlylce	159	24	47	47	CD
cord-326960-9phlylce	159	25	]	]	-RRB-
cord-326960-9phlylce	159	26	.	.	.
cord-326960-9phlylce	160	1	Some	some	DT
cord-326960-9phlylce	160	2	developments	development	NNS
cord-326960-9phlylce	160	3	have	have	VBP
cord-326960-9phlylce	160	4	been	be	VBN
cord-326960-9phlylce	160	5	made	make	VBN
cord-326960-9phlylce	160	6	to	to	TO
cord-326960-9phlylce	160	7	address	address	VB
cord-326960-9phlylce	160	8	this	this	DT
cord-326960-9phlylce	160	9	limitation	limitation	NN
cord-326960-9phlylce	160	10	,	,	,
cord-326960-9phlylce	160	11	including	include	VBG
cord-326960-9phlylce	160	12	engineering	engineer	VBG
cord-326960-9phlylce	160	13	transgenic	transgenic	JJ
cord-326960-9phlylce	160	14	insect	insect	NN
cord-326960-9phlylce	160	15	cell	cell	NN
cord-326960-9phlylce	160	16	lines	line	NNS
cord-326960-9phlylce	160	17	that	that	WDT
cord-326960-9phlylce	160	18	stably	stably	RB
cord-326960-9phlylce	160	19	express	express	VBP
cord-326960-9phlylce	160	20	mammalian	mammalian	JJ
cord-326960-9phlylce	160	21	glycosylation	glycosylation	NN
cord-326960-9phlylce	160	22	enzymes	enzyme	NNS
cord-326960-9phlylce	160	23	or	or	CC
cord-326960-9phlylce	160	24	co	co	VBP
cord-326960-9phlylce	160	25	-	-	JJ
cord-326960-9phlylce	160	26	expressing	express	VBG
cord-326960-9phlylce	160	27	such	such	JJ
cord-326960-9phlylce	160	28	enzymes	enzyme	NNS
cord-326960-9phlylce	160	29	with	with	IN
cord-326960-9phlylce	160	30	the	the	DT
cord-326960-9phlylce	160	31	gene	gene	NN
cord-326960-9phlylce	160	32	of	of	IN
cord-326960-9phlylce	160	33	interest	interest	NN
cord-326960-9phlylce	160	34	in	in	IN
cord-326960-9phlylce	160	35	a	a	DT
cord-326960-9phlylce	160	36	single	single	JJ
cord-326960-9phlylce	160	37	baculovirus	baculovirus	NN
cord-326960-9phlylce	160	38	[	[	-LRB-
cord-326960-9phlylce	160	39	48	48	CD
cord-326960-9phlylce	160	40	]	]	-RRB-
cord-326960-9phlylce	160	41	[	[	-LRB-
cord-326960-9phlylce	160	42	49	49	CD
cord-326960-9phlylce	160	43	]	]	-RRB-
cord-326960-9phlylce	160	44	[	[	-LRB-
cord-326960-9phlylce	160	45	50	50	CD
cord-326960-9phlylce	160	46	]	]	-RRB-
cord-326960-9phlylce	160	47	[	[	-LRB-
cord-326960-9phlylce	160	48	51	51	CD
cord-326960-9phlylce	160	49	]	]	-RRB-
cord-326960-9phlylce	160	50	.	.	.
cord-326960-9phlylce	161	1	Whether	whether	IN
cord-326960-9phlylce	161	2	this	this	DT
cord-326960-9phlylce	161	3	is	be	VBZ
cord-326960-9phlylce	161	4	required	require	VBN
cord-326960-9phlylce	161	5	must	must	MD
cord-326960-9phlylce	161	6	be	be	VB
cord-326960-9phlylce	161	7	assessed	assess	VBN
cord-326960-9phlylce	161	8	on	on	IN
cord-326960-9phlylce	161	9	a	a	DT
cord-326960-9phlylce	161	10	protein	protein	NN
cord-326960-9phlylce	161	11	by	by	IN
cord-326960-9phlylce	161	12	protein	protein	NN
cord-326960-9phlylce	161	13	basis	basis	NN
cord-326960-9phlylce	161	14	.	.	.
cord-326960-9phlylce	162	1	Licensure	licensure	NN
cord-326960-9phlylce	162	2	of	of	IN
cord-326960-9phlylce	162	3	the	the	DT
cord-326960-9phlylce	162	4	first	first	JJ
cord-326960-9phlylce	162	5	BEVS	bevs	NN
cord-326960-9phlylce	162	6	-	-	HYPH
cord-326960-9phlylce	162	7	derived	derive	VBN
cord-326960-9phlylce	162	8	products	product	NNS
cord-326960-9phlylce	162	9	has	have	VBZ
cord-326960-9phlylce	162	10	paved	pave	VBN
cord-326960-9phlylce	162	11	a	a	DT
cord-326960-9phlylce	162	12	regulatory	regulatory	JJ
cord-326960-9phlylce	162	13	pathway	pathway	NN
cord-326960-9phlylce	162	14	,	,	,
cord-326960-9phlylce	162	15	reducing	reduce	VBG
cord-326960-9phlylce	162	16	regulatory	regulatory	JJ
cord-326960-9phlylce	162	17	uncertainty	uncertainty	NN
cord-326960-9phlylce	162	18	.	.	.
cord-326960-9phlylce	163	1	In	in	IN
cord-326960-9phlylce	163	2	this	this	DT
cord-326960-9phlylce	163	3	section	section	NN
cord-326960-9phlylce	163	4	we	-PRON-	PRP
cord-326960-9phlylce	163	5	discuss	discuss	VBP
cord-326960-9phlylce	163	6	opportunities	opportunity	NNS
cord-326960-9phlylce	163	7	in	in	IN
cord-326960-9phlylce	163	8	the	the	DT
cord-326960-9phlylce	163	9	areas	area	NNS
cord-326960-9phlylce	163	10	of	of	IN
cord-326960-9phlylce	163	11	gene	gene	NN
cord-326960-9phlylce	163	12	therapy	therapy	NN
cord-326960-9phlylce	163	13	and	and	CC
cord-326960-9phlylce	163	14	influenza	influenza	NN
cord-326960-9phlylce	163	15	vaccines	vaccine	NNS
cord-326960-9phlylce	163	16	spawned	spawn	VBN
cord-326960-9phlylce	163	17	by	by	IN
cord-326960-9phlylce	163	18	the	the	DT
cord-326960-9phlylce	163	19	two	two	CD
cord-326960-9phlylce	163	20	most	most	RBS
cord-326960-9phlylce	163	21	recent	recent	JJ
cord-326960-9phlylce	163	22	BEVS	bevs	NN
cord-326960-9phlylce	163	23	-	-	HYPH
cord-326960-9phlylce	163	24	derived	derive	VBN
cord-326960-9phlylce	163	25	product	product	NN
cord-326960-9phlylce	163	26	approvals	approval	NNS
cord-326960-9phlylce	163	27	,	,	,
cord-326960-9phlylce	163	28	Glybera	Glybera	NNP
cord-326960-9phlylce	163	29	®	®	VBP
cord-326960-9phlylce	163	30	(	(	-LRB-
cord-326960-9phlylce	163	31	licensed	license	VBN
cord-326960-9phlylce	163	32	by	by	IN
cord-326960-9phlylce	163	33	the	the	DT
cord-326960-9phlylce	163	34	EMA	EMA	NNP
cord-326960-9phlylce	163	35	in	in	IN
cord-326960-9phlylce	163	36	2012	2012	CD
cord-326960-9phlylce	163	37	)	)	-RRB-
cord-326960-9phlylce	163	38	and	and	CC
cord-326960-9phlylce	163	39	Flublok	Flublok	NNP
cord-326960-9phlylce	163	40	®	®	NNP
cord-326960-9phlylce	163	41	(	(	-LRB-
cord-326960-9phlylce	163	42	licensed	license	VBN
cord-326960-9phlylce	163	43	by	by	IN
cord-326960-9phlylce	163	44	the	the	DT
cord-326960-9phlylce	163	45	FDA	FDA	NNP
cord-326960-9phlylce	163	46	in	in	IN
cord-326960-9phlylce	163	47	2013	2013	CD
cord-326960-9phlylce	163	48	)	)	-RRB-
cord-326960-9phlylce	163	49	,	,	,
cord-326960-9phlylce	163	50	respectively	respectively	RB
cord-326960-9phlylce	163	51	.	.	.
cord-326960-9phlylce	164	1	The	the	DT
cord-326960-9phlylce	164	2	BEVS	BEVS	NNP
cord-326960-9phlylce	164	3	approach	approach	NN
cord-326960-9phlylce	164	4	to	to	IN
cord-326960-9phlylce	164	5	gene	gene	NN
cord-326960-9phlylce	164	6	therapy	therapy	NN
cord-326960-9phlylce	164	7	has	have	VBZ
cord-326960-9phlylce	164	8	largely	largely	RB
cord-326960-9phlylce	164	9	involved	involve	VBN
cord-326960-9phlylce	164	10	the	the	DT
cord-326960-9phlylce	164	11	production	production	NN
cord-326960-9phlylce	164	12	of	of	IN
cord-326960-9phlylce	164	13	recombinant	recombinant	JJ
cord-326960-9phlylce	164	14	adeno	adeno	NN
cord-326960-9phlylce	164	15	-	-	HYPH
cord-326960-9phlylce	164	16	associated	associate	VBN
cord-326960-9phlylce	164	17	viruses	virus	NNS
cord-326960-9phlylce	164	18	(	(	-LRB-
cord-326960-9phlylce	164	19	rAAVs	raavs	ADD
cord-326960-9phlylce	164	20	)	)	-RRB-
cord-326960-9phlylce	164	21	that	that	IN
cord-326960-9phlylce	164	22	house	house	NN
cord-326960-9phlylce	164	23	therapeutic	therapeutic	JJ
cord-326960-9phlylce	164	24	DNA	DNA	NNP
cord-326960-9phlylce	164	25	.	.	.
cord-326960-9phlylce	165	1	The	the	DT
cord-326960-9phlylce	165	2	use	use	NN
cord-326960-9phlylce	165	3	of	of	IN
cord-326960-9phlylce	165	4	rAAVs	raavs	ADD
cord-326960-9phlylce	165	5	as	as	IN
cord-326960-9phlylce	165	6	a	a	DT
cord-326960-9phlylce	165	7	gene	gene	NN
cord-326960-9phlylce	165	8	delivery	delivery	NN
cord-326960-9phlylce	165	9	vector	vector	NN
cord-326960-9phlylce	165	10	has	have	VBZ
cord-326960-9phlylce	165	11	gained	gain	VBN
cord-326960-9phlylce	165	12	popularity	popularity	NN
cord-326960-9phlylce	165	13	for	for	IN
cord-326960-9phlylce	165	14	several	several	JJ
cord-326960-9phlylce	165	15	reasons	reason	NNS
cord-326960-9phlylce	165	16	,	,	,
cord-326960-9phlylce	165	17	including	include	VBG
cord-326960-9phlylce	165	18	long	long	JJ
cord-326960-9phlylce	165	19	-	-	HYPH
cord-326960-9phlylce	165	20	term	term	NN
cord-326960-9phlylce	165	21	gene	gene	NN
cord-326960-9phlylce	165	22	expression	expression	NN
cord-326960-9phlylce	165	23	,	,	,
cord-326960-9phlylce	165	24	lack	lack	NN
cord-326960-9phlylce	165	25	of	of	IN
cord-326960-9phlylce	165	26	pathogenicity	pathogenicity	NN
cord-326960-9phlylce	165	27	and	and	CC
cord-326960-9phlylce	165	28	ability	ability	NN
cord-326960-9phlylce	165	29	to	to	TO
cord-326960-9phlylce	165	30	transduce	transduce	VB
cord-326960-9phlylce	165	31	a	a	DT
cord-326960-9phlylce	165	32	wide	wide	JJ
cord-326960-9phlylce	165	33	variety	variety	NN
cord-326960-9phlylce	165	34	of	of	IN
cord-326960-9phlylce	165	35	cells	cell	NNS
cord-326960-9phlylce	165	36	,	,	,
cord-326960-9phlylce	165	37	both	both	DT
cord-326960-9phlylce	165	38	dividing	divide	VBG
cord-326960-9phlylce	165	39	and	and	CC
cord-326960-9phlylce	165	40	non	non	JJ
cord-326960-9phlylce	165	41	-	-	JJ
cord-326960-9phlylce	165	42	dividing	dividing	JJ
cord-326960-9phlylce	165	43	[	[	-LRB-
cord-326960-9phlylce	165	44	52	52	CD
cord-326960-9phlylce	165	45	,	,	,
cord-326960-9phlylce	165	46	53	53	CD
cord-326960-9phlylce	165	47	]	]	-RRB-
cord-326960-9phlylce	165	48	.	.	.
cord-326960-9phlylce	166	1	Nine	nine	CD
cord-326960-9phlylce	166	2	different	different	JJ
cord-326960-9phlylce	166	3	rAAV	rAAV	NNS
cord-326960-9phlylce	166	4	serotypes	serotype	NNS
cord-326960-9phlylce	166	5	(	(	-LRB-
cord-326960-9phlylce	166	6	1	1	CD
cord-326960-9phlylce	166	7	-	-	SYM
cord-326960-9phlylce	166	8	9	9	CD
cord-326960-9phlylce	166	9	)	)	-RRB-
cord-326960-9phlylce	166	10	are	be	VBP
cord-326960-9phlylce	166	11	most	most	RBS
cord-326960-9phlylce	166	12	commonly	commonly	RB
cord-326960-9phlylce	166	13	used	use	VBN
cord-326960-9phlylce	166	14	for	for	IN
cord-326960-9phlylce	166	15	rAAV	raav	NN
cord-326960-9phlylce	166	16	-	-	HYPH
cord-326960-9phlylce	166	17	based	base	VBN
cord-326960-9phlylce	166	18	gene	gene	NN
cord-326960-9phlylce	166	19	therapy	therapy	NN
cord-326960-9phlylce	166	20	,	,	,
cord-326960-9phlylce	166	21	each	each	DT
cord-326960-9phlylce	166	22	serotype	serotype	NN
cord-326960-9phlylce	166	23	with	with	IN
cord-326960-9phlylce	166	24	a	a	DT
cord-326960-9phlylce	166	25	different	different	JJ
cord-326960-9phlylce	166	26	propensity	propensity	NN
cord-326960-9phlylce	166	27	for	for	IN
cord-326960-9phlylce	166	28	tissue	tissue	NN
cord-326960-9phlylce	166	29	-	-	HYPH
cord-326960-9phlylce	166	30	specific	specific	JJ
cord-326960-9phlylce	166	31	infection	infection	NN
cord-326960-9phlylce	166	32	and	and	CC
cord-326960-9phlylce	166	33	infection	infection	NN
cord-326960-9phlylce	166	34	kinetics	kinetic	NNS
cord-326960-9phlylce	166	35	[	[	-LRB-
cord-326960-9phlylce	166	36	54	54	CD
cord-326960-9phlylce	166	37	]	]	-RRB-
cord-326960-9phlylce	166	38	.	.	.
cord-326960-9phlylce	167	1	Recombinant	Recombinant	NNP
cord-326960-9phlylce	167	2	AAV	AAV	NNP
cord-326960-9phlylce	167	3	-	-	HYPH
cord-326960-9phlylce	167	4	based	base	VBN
cord-326960-9phlylce	167	5	gene	gene	NN
cord-326960-9phlylce	167	6	therapies	therapy	NNS
cord-326960-9phlylce	167	7	have	have	VBP
cord-326960-9phlylce	167	8	been	be	VBN
cord-326960-9phlylce	167	9	in	in	IN
cord-326960-9phlylce	167	10	development	development	NN
cord-326960-9phlylce	167	11	and	and	CC
cord-326960-9phlylce	167	12	shown	show	VBN
cord-326960-9phlylce	167	13	promise	promise	NN
cord-326960-9phlylce	167	14	for	for	IN
cord-326960-9phlylce	167	15	some	some	DT
cord-326960-9phlylce	167	16	time	time	NN
cord-326960-9phlylce	167	17	;	;	:
cord-326960-9phlylce	167	18	however	however	RB
cord-326960-9phlylce	167	19	,	,	,
cord-326960-9phlylce	167	20	a	a	DT
cord-326960-9phlylce	167	21	major	major	JJ
cord-326960-9phlylce	167	22	limitation	limitation	NN
cord-326960-9phlylce	167	23	to	to	IN
cord-326960-9phlylce	167	24	their	-PRON-	PRP$
cord-326960-9phlylce	167	25	implementation	implementation	NN
cord-326960-9phlylce	167	26	had	have	VBD
cord-326960-9phlylce	167	27	been	be	VBN
cord-326960-9phlylce	167	28	the	the	DT
cord-326960-9phlylce	167	29	inability	inability	NN
cord-326960-9phlylce	167	30	to	to	TO
cord-326960-9phlylce	167	31	scale	scale	VB
cord-326960-9phlylce	167	32	up	up	RP
cord-326960-9phlylce	167	33	the	the	DT
cord-326960-9phlylce	167	34	manufacturing	manufacturing	NN
cord-326960-9phlylce	167	35	process	process	NN
cord-326960-9phlylce	167	36	to	to	TO
cord-326960-9phlylce	167	37	produce	produce	VB
cord-326960-9phlylce	167	38	sufficient	sufficient	JJ
cord-326960-9phlylce	167	39	quantities	quantity	NNS
cord-326960-9phlylce	167	40	of	of	IN
cord-326960-9phlylce	167	41	rAAVs	raavs	ADD
cord-326960-9phlylce	167	42	.	.	.
cord-326960-9phlylce	168	1	The	the	DT
cord-326960-9phlylce	168	2	original	original	JJ
cord-326960-9phlylce	168	3	rAAV	rAAV	NNS
cord-326960-9phlylce	168	4	vectors	vector	NNS
cord-326960-9phlylce	168	5	were	be	VBD
cord-326960-9phlylce	168	6	produced	produce	VBN
cord-326960-9phlylce	168	7	in	in	IN
cord-326960-9phlylce	168	8	mammalian	mammalian	JJ
cord-326960-9phlylce	168	9	tissue	tissue	NN
cord-326960-9phlylce	168	10	culture	culture	NN
cord-326960-9phlylce	168	11	using	use	VBG
cord-326960-9phlylce	168	12	adherent	adherent	JJ
cord-326960-9phlylce	168	13	cells	cell	NNS
cord-326960-9phlylce	168	14	such	such	JJ
cord-326960-9phlylce	168	15	as	as	IN
cord-326960-9phlylce	168	16	HEK293	HEK293	NNP
cord-326960-9phlylce	168	17	cells	cell	NNS
cord-326960-9phlylce	168	18	,	,	,
cord-326960-9phlylce	168	19	which	which	WDT
cord-326960-9phlylce	168	20	required	require	VBD
cord-326960-9phlylce	168	21	about	about	RB
cord-326960-9phlylce	168	22	5000	5000	CD
cord-326960-9phlylce	168	23	175-cm	175-cm	CD
cord-326960-9phlylce	168	24	2	2	CD
cord-326960-9phlylce	168	25	flasks	flask	NNS
cord-326960-9phlylce	168	26	to	to	TO
cord-326960-9phlylce	168	27	produce	produce	VB
cord-326960-9phlylce	168	28	enough	enough	JJ
cord-326960-9phlylce	168	29	material	material	NN
cord-326960-9phlylce	168	30	for	for	IN
cord-326960-9phlylce	168	31	a	a	DT
cord-326960-9phlylce	168	32	large	large	JJ
cord-326960-9phlylce	168	33	animal	animal	NN
cord-326960-9phlylce	168	34	study	study	NN
cord-326960-9phlylce	168	35	or	or	CC
cord-326960-9phlylce	168	36	human	human	JJ
cord-326960-9phlylce	168	37	clinical	clinical	JJ
cord-326960-9phlylce	168	38	trial	trial	NN
cord-326960-9phlylce	168	39	(	(	-LRB-
cord-326960-9phlylce	168	40	~10	~10	DT
cord-326960-9phlylce	168	41	15	15	CD
cord-326960-9phlylce	168	42	rAAV	raav	NN
cord-326960-9phlylce	168	43	particles	particle	NNS
cord-326960-9phlylce	168	44	)	)	-RRB-
cord-326960-9phlylce	168	45	[	[	-LRB-
cord-326960-9phlylce	168	46	55	55	CD
cord-326960-9phlylce	168	47	]	]	-RRB-
cord-326960-9phlylce	168	48	.	.	.
cord-326960-9phlylce	169	1	To	to	TO
cord-326960-9phlylce	169	2	overcome	overcome	VB
cord-326960-9phlylce	169	3	this	this	DT
cord-326960-9phlylce	169	4	limitation	limitation	NN
cord-326960-9phlylce	169	5	,	,	,
cord-326960-9phlylce	169	6	scientists	scientist	NNS
cord-326960-9phlylce	169	7	adopted	adopt	VBD
cord-326960-9phlylce	169	8	and	and	CC
cord-326960-9phlylce	169	9	optimized	optimize	VBD
cord-326960-9phlylce	169	10	the	the	DT
cord-326960-9phlylce	169	11	BEVS	BEVS	NNP
cord-326960-9phlylce	169	12	platform	platform	NN
cord-326960-9phlylce	169	13	for	for	IN
cord-326960-9phlylce	169	14	production	production	NN
cord-326960-9phlylce	169	15	of	of	IN
cord-326960-9phlylce	169	16	large	large	JJ
cord-326960-9phlylce	169	17	scale	scale	NN
cord-326960-9phlylce	169	18	,	,	,
cord-326960-9phlylce	169	19	high	high	JJ
cord-326960-9phlylce	169	20	titer	titer	NN
cord-326960-9phlylce	169	21	rAAVs	raavs	ADD
cord-326960-9phlylce	170	1	[	[	-LRB-
cord-326960-9phlylce	170	2	55	55	CD
cord-326960-9phlylce	170	3	]	]	-RRB-
cord-326960-9phlylce	170	4	[	[	-LRB-
cord-326960-9phlylce	170	5	56	56	CD
cord-326960-9phlylce	170	6	]	]	-RRB-
cord-326960-9phlylce	170	7	[	[	-LRB-
cord-326960-9phlylce	170	8	57	57	CD
cord-326960-9phlylce	170	9	]	]	-RRB-
cord-326960-9phlylce	170	10	[	[	-LRB-
cord-326960-9phlylce	170	11	58	58	CD
cord-326960-9phlylce	170	12	]	]	-RRB-
cord-326960-9phlylce	170	13	[	[	-LRB-
cord-326960-9phlylce	170	14	59	59	CD
cord-326960-9phlylce	170	15	]	]	-RRB-
cord-326960-9phlylce	171	1	[	[	-LRB-
cord-326960-9phlylce	171	2	60	60	CD
cord-326960-9phlylce	171	3	]	]	-RRB-
cord-326960-9phlylce	171	4	[	[	-LRB-
cord-326960-9phlylce	171	5	61	61	CD
cord-326960-9phlylce	171	6	]	]	-RRB-
cord-326960-9phlylce	172	1	[	[	-LRB-
cord-326960-9phlylce	172	2	62	62	CD
cord-326960-9phlylce	172	3	]	]	-RRB-
cord-326960-9phlylce	172	4	[	[	-LRB-
cord-326960-9phlylce	172	5	63	63	CD
cord-326960-9phlylce	172	6	]	]	-RRB-
cord-326960-9phlylce	172	7	.	.	.
cord-326960-9phlylce	173	1	By	by	IN
cord-326960-9phlylce	173	2	adjusting	adjust	VBG
cord-326960-9phlylce	173	3	parameters	parameter	NNS
cord-326960-9phlylce	173	4	such	such	JJ
cord-326960-9phlylce	173	5	as	as	IN
cord-326960-9phlylce	173	6	multiplicity	multiplicity	NN
cord-326960-9phlylce	173	7	of	of	IN
cord-326960-9phlylce	173	8	infection	infection	NN
cord-326960-9phlylce	173	9	,	,	,
cord-326960-9phlylce	173	10	cell	cell	NN
cord-326960-9phlylce	173	11	density	density	NN
cord-326960-9phlylce	173	12	and	and	CC
cord-326960-9phlylce	173	13	fermentation	fermentation	NN
cord-326960-9phlylce	173	14	mode	mode	NN
cord-326960-9phlylce	173	15	,	,	,
cord-326960-9phlylce	173	16	rAAV	raav	NN
cord-326960-9phlylce	173	17	yields	yield	NNS
cord-326960-9phlylce	173	18	on	on	IN
cord-326960-9phlylce	173	19	the	the	DT
cord-326960-9phlylce	173	20	order	order	NN
cord-326960-9phlylce	173	21	of	of	IN
cord-326960-9phlylce	173	22	10	10	CD
cord-326960-9phlylce	173	23	14	14	CD
cord-326960-9phlylce	173	24	vector	vector	NN
cord-326960-9phlylce	173	25	genomes	genome	NNS
cord-326960-9phlylce	173	26	per	per	IN
cord-326960-9phlylce	173	27	liter	liter	NN
cord-326960-9phlylce	173	28	have	have	VBP
cord-326960-9phlylce	173	29	been	be	VBN
cord-326960-9phlylce	173	30	reported	report	VBN
cord-326960-9phlylce	173	31	[	[	-LRB-
cord-326960-9phlylce	173	32	57	57	CD
cord-326960-9phlylce	173	33	]	]	-RRB-
cord-326960-9phlylce	173	34	.	.	.
cord-326960-9phlylce	174	1	The	the	DT
cord-326960-9phlylce	174	2	traditional	traditional	JJ
cord-326960-9phlylce	174	3	BEVS	bevs	NN
cord-326960-9phlylce	174	4	production	production	NN
cord-326960-9phlylce	174	5	strategy	strategy	NN
cord-326960-9phlylce	174	6	for	for	IN
cord-326960-9phlylce	174	7	rAAVs	rAAVs	NNP
cord-326960-9phlylce	174	8	requires	require	VBZ
cord-326960-9phlylce	174	9	the	the	DT
cord-326960-9phlylce	174	10	co	co	NN
cord-326960-9phlylce	174	11	-	-	NN
cord-326960-9phlylce	174	12	infection	infection	NN
cord-326960-9phlylce	174	13	of	of	IN
cord-326960-9phlylce	174	14	insect	insect	NN
cord-326960-9phlylce	174	15	cells	cell	NNS
cord-326960-9phlylce	174	16	with	with	IN
cord-326960-9phlylce	174	17	three	three	CD
cord-326960-9phlylce	174	18	differ	differ	NNS
cord-326960-9phlylce	174	19	-	-	HYPH
cord-326960-9phlylce	174	20	ent	ent	NN
cord-326960-9phlylce	174	21	recombinant	recombinant	JJ
cord-326960-9phlylce	174	22	baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	174	23	:	:	:
cord-326960-9phlylce	175	1	Bac	Bac	NNP
cord-326960-9phlylce	175	2	-	-	HYPH
cord-326960-9phlylce	175	3	Rep	Rep	NNP
cord-326960-9phlylce	175	4	that	that	WDT
cord-326960-9phlylce	175	5	expresses	express	VBZ
cord-326960-9phlylce	175	6	the	the	DT
cord-326960-9phlylce	175	7	major	major	JJ
cord-326960-9phlylce	175	8	AAV	AAV	NNP
cord-326960-9phlylce	175	9	replication	replication	NN
cord-326960-9phlylce	175	10	enzymes	enzyme	NNS
cord-326960-9phlylce	175	11	(	(	-LRB-
cord-326960-9phlylce	175	12	Rep78	Rep78	NNP
cord-326960-9phlylce	175	13	and	and	CC
cord-326960-9phlylce	175	14	Rep52	Rep52	NNP
cord-326960-9phlylce	175	15	)	)	-RRB-
cord-326960-9phlylce	175	16	;	;	:
cord-326960-9phlylce	175	17	Bac	Bac	NNP
cord-326960-9phlylce	175	18	-	-	HYPH
cord-326960-9phlylce	175	19	Cap	Cap	NNP
cord-326960-9phlylce	175	20	that	that	WDT
cord-326960-9phlylce	175	21	expresses	express	VBZ
cord-326960-9phlylce	175	22	the	the	DT
cord-326960-9phlylce	175	23	AAV	AAV	NNP
cord-326960-9phlylce	175	24	virion	virion	NN
cord-326960-9phlylce	175	25	coat	coat	NN
cord-326960-9phlylce	175	26	proteins	protein	NNS
cord-326960-9phlylce	175	27	;	;	:
cord-326960-9phlylce	175	28	and	and	CC
cord-326960-9phlylce	175	29	Bac	Bac	NNP
cord-326960-9phlylce	175	30	-	-	HYPH
cord-326960-9phlylce	175	31	GOI	GOI	NNP
cord-326960-9phlylce	175	32	that	that	WDT
cord-326960-9phlylce	175	33	expresses	express	VBZ
cord-326960-9phlylce	175	34	the	the	DT
cord-326960-9phlylce	175	35	gene	gene	NN
cord-326960-9phlylce	175	36	of	of	IN
cord-326960-9phlylce	175	37	interest	interest	NN
cord-326960-9phlylce	175	38	flanked	flank	VBN
cord-326960-9phlylce	175	39	by	by	IN
cord-326960-9phlylce	175	40	the	the	DT
cord-326960-9phlylce	175	41	AAV	AAV	NNP
cord-326960-9phlylce	175	42	inverted	invert	VBN
cord-326960-9phlylce	175	43	terminal	terminal	JJ
cord-326960-9phlylce	175	44	repeat	repeat	NN
cord-326960-9phlylce	175	45	elements	element	NNS
cord-326960-9phlylce	175	46	that	that	WDT
cord-326960-9phlylce	175	47	are	be	VBP
cord-326960-9phlylce	175	48	required	require	VBN
cord-326960-9phlylce	175	49	for	for	IN
cord-326960-9phlylce	175	50	the	the	DT
cord-326960-9phlylce	175	51	rescue	rescue	NN
cord-326960-9phlylce	175	52	,	,	,
cord-326960-9phlylce	175	53	replication	replication	NN
cord-326960-9phlylce	175	54	and	and	CC
cord-326960-9phlylce	175	55	packaging	packaging	NN
cord-326960-9phlylce	175	56	of	of	IN
cord-326960-9phlylce	175	57	the	the	DT
cord-326960-9phlylce	175	58	gene	gene	NN
cord-326960-9phlylce	175	59	[	[	-LRB-
cord-326960-9phlylce	175	60	55	55	CD
cord-326960-9phlylce	175	61	,	,	,
cord-326960-9phlylce	175	62	56	56	CD
cord-326960-9phlylce	175	63	]	]	-RRB-
cord-326960-9phlylce	175	64	.	.	.
cord-326960-9phlylce	176	1	No	no	DT
cord-326960-9phlylce	176	2	adenovirus	adenovirus	NN
cord-326960-9phlylce	176	3	helper	helper	NN
cord-326960-9phlylce	176	4	is	be	VBZ
cord-326960-9phlylce	176	5	needed	need	VBN
cord-326960-9phlylce	176	6	as	as	IN
cord-326960-9phlylce	176	7	is	be	VBZ
cord-326960-9phlylce	176	8	required	require	VBN
cord-326960-9phlylce	176	9	for	for	IN
cord-326960-9phlylce	176	10	mammalian	mammalian	JJ
cord-326960-9phlylce	176	11	cell	cell	NN
cord-326960-9phlylce	176	12	rAAV	raav	NN
cord-326960-9phlylce	176	13	production	production	NN
cord-326960-9phlylce	176	14	[	[	-LRB-
cord-326960-9phlylce	176	15	64	64	CD
cord-326960-9phlylce	176	16	,	,	,
cord-326960-9phlylce	176	17	65	65	CD
cord-326960-9phlylce	176	18	]	]	-RRB-
cord-326960-9phlylce	176	19	.	.	.
cord-326960-9phlylce	177	1	Due	due	IN
cord-326960-9phlylce	177	2	to	to	IN
cord-326960-9phlylce	177	3	some	some	DT
cord-326960-9phlylce	177	4	genetic	genetic	JJ
cord-326960-9phlylce	177	5	instability	instability	NN
cord-326960-9phlylce	177	6	of	of	IN
cord-326960-9phlylce	177	7	the	the	DT
cord-326960-9phlylce	177	8	Bac	Bac	NNP
cord-326960-9phlylce	177	9	-	-	HYPH
cord-326960-9phlylce	177	10	Rep	Rep	NNP
cord-326960-9phlylce	177	11	construct	construct	VB
cord-326960-9phlylce	177	12	,	,	,
cord-326960-9phlylce	177	13	a	a	DT
cord-326960-9phlylce	177	14	streamlined	streamlined	JJ
cord-326960-9phlylce	177	15	two	two	CD
cord-326960-9phlylce	177	16	-	-	HYPH
cord-326960-9phlylce	177	17	baculovirus	baculovirus	NN
cord-326960-9phlylce	177	18	system	system	NN
cord-326960-9phlylce	177	19	has	have	VBZ
cord-326960-9phlylce	177	20	further	further	RB
cord-326960-9phlylce	177	21	been	be	VBN
cord-326960-9phlylce	177	22	developed	develop	VBN
cord-326960-9phlylce	177	23	where	where	WRB
cord-326960-9phlylce	177	24	Rep	Rep	NNP
cord-326960-9phlylce	177	25	and	and	CC
cord-326960-9phlylce	177	26	Cap	Cap	NNP
cord-326960-9phlylce	177	27	proteins	protein	NNS
cord-326960-9phlylce	177	28	are	be	VBP
cord-326960-9phlylce	177	29	expressed	express	VBN
cord-326960-9phlylce	177	30	from	from	IN
cord-326960-9phlylce	177	31	a	a	DT
cord-326960-9phlylce	177	32	single	single	JJ
cord-326960-9phlylce	177	33	baculovirus	baculovirus	NN
cord-326960-9phlylce	177	34	(	(	-LRB-
cord-326960-9phlylce	177	35	Bac	Bac	NNP
cord-326960-9phlylce	177	36	-	-	HYPH
cord-326960-9phlylce	177	37	RepCap	RepCap	NNP
cord-326960-9phlylce	177	38	)	)	-RRB-
cord-326960-9phlylce	178	1	and	and	CC
cord-326960-9phlylce	178	2	Rep78	Rep78	NNP
cord-326960-9phlylce	178	3	and	and	CC
cord-326960-9phlylce	178	4	Rep52	Rep52	NNP
cord-326960-9phlylce	178	5	are	be	VBP
cord-326960-9phlylce	178	6	transcribed	transcribe	VBN
cord-326960-9phlylce	178	7	from	from	IN
cord-326960-9phlylce	178	8	a	a	DT
cord-326960-9phlylce	178	9	single	single	JJ
cord-326960-9phlylce	178	10	mRNA	mrna	NN
cord-326960-9phlylce	178	11	species	specie	NNS
cord-326960-9phlylce	178	12	that	that	WDT
cord-326960-9phlylce	178	13	enhances	enhance	VBZ
cord-326960-9phlylce	178	14	stability	stability	NN
cord-326960-9phlylce	178	15	[	[	-LRB-
cord-326960-9phlylce	178	16	56	56	CD
cord-326960-9phlylce	178	17	]	]	-RRB-
cord-326960-9phlylce	178	18	.	.	.
cord-326960-9phlylce	179	1	Alternatively	alternatively	RB
cord-326960-9phlylce	179	2	,	,	,
cord-326960-9phlylce	179	3	genetic	genetic	JJ
cord-326960-9phlylce	179	4	modifications	modification	NNS
cord-326960-9phlylce	179	5	have	have	VBP
cord-326960-9phlylce	179	6	been	be	VBN
cord-326960-9phlylce	179	7	made	make	VBN
cord-326960-9phlylce	179	8	to	to	IN
cord-326960-9phlylce	179	9	the	the	DT
cord-326960-9phlylce	179	10	original	original	JJ
cord-326960-9phlylce	179	11	Bac	Bac	NNP
cord-326960-9phlylce	179	12	-	-	HYPH
cord-326960-9phlylce	179	13	Rep	Rep	NNP
cord-326960-9phlylce	179	14	and	and	CC
cord-326960-9phlylce	179	15	Bac	Bac	NNP
cord-326960-9phlylce	179	16	-	-	HYPH
cord-326960-9phlylce	179	17	Cap	Cap	NNP
cord-326960-9phlylce	179	18	constructs	construct	NNS
cord-326960-9phlylce	179	19	to	to	TO
cord-326960-9phlylce	179	20	enhance	enhance	VB
cord-326960-9phlylce	179	21	stability	stability	NN
cord-326960-9phlylce	179	22	and	and	CC
cord-326960-9phlylce	179	23	improve	improve	VB
cord-326960-9phlylce	179	24	expression	expression	NN
cord-326960-9phlylce	179	25	[	[	-LRB-
cord-326960-9phlylce	179	26	58	58	CD
cord-326960-9phlylce	179	27	]	]	-RRB-
cord-326960-9phlylce	179	28	.	.	.
cord-326960-9phlylce	180	1	An	an	DT
cord-326960-9phlylce	180	2	important	important	JJ
cord-326960-9phlylce	180	3	regulatory	regulatory	JJ
cord-326960-9phlylce	180	4	hurdle	hurdle	NN
cord-326960-9phlylce	180	5	was	be	VBD
cord-326960-9phlylce	180	6	overcome	overcome	VBN
cord-326960-9phlylce	180	7	in	in	IN
cord-326960-9phlylce	180	8	2012	2012	CD
cord-326960-9phlylce	180	9	when	when	WRB
cord-326960-9phlylce	180	10	Glybera	Glybera	NNP
cord-326960-9phlylce	180	11	received	receive	VBD
cord-326960-9phlylce	180	12	marketing	marketing	NN
cord-326960-9phlylce	180	13	authorization	authorization	NN
cord-326960-9phlylce	180	14	in	in	IN
cord-326960-9phlylce	180	15	Europe	Europe	NNP
cord-326960-9phlylce	180	16	,	,	,
cord-326960-9phlylce	180	17	making	make	VBG
cord-326960-9phlylce	180	18	it	-PRON-	PRP
cord-326960-9phlylce	180	19	the	the	DT
cord-326960-9phlylce	180	20	first	first	JJ
cord-326960-9phlylce	180	21	gene	gene	NN
cord-326960-9phlylce	180	22	therapy	therapy	NN
cord-326960-9phlylce	180	23	product	product	NN
cord-326960-9phlylce	180	24	approved	approve	VBN
cord-326960-9phlylce	180	25	in	in	IN
cord-326960-9phlylce	180	26	the	the	DT
cord-326960-9phlylce	180	27	Western	western	JJ
cord-326960-9phlylce	180	28	world	world	NN
cord-326960-9phlylce	180	29	and	and	CC
cord-326960-9phlylce	180	30	launching	launch	VBG
cord-326960-9phlylce	180	31	the	the	DT
cord-326960-9phlylce	180	32	BEVS	BEVS	NNP
cord-326960-9phlylce	180	33	platform	platform	NN
cord-326960-9phlylce	180	34	into	into	IN
cord-326960-9phlylce	180	35	the	the	DT
cord-326960-9phlylce	180	36	spotlight	spotlight	NN
cord-326960-9phlylce	180	37	as	as	IN
cord-326960-9phlylce	180	38	a	a	DT
cord-326960-9phlylce	180	39	preferred	preferred	JJ
cord-326960-9phlylce	180	40	platform	platform	NN
cord-326960-9phlylce	180	41	for	for	IN
cord-326960-9phlylce	180	42	rAAV	rAAV	NNP
cord-326960-9phlylce	180	43	manufacture	manufacture	NN
cord-326960-9phlylce	180	44	.	.	.
cord-326960-9phlylce	181	1	Glybera	Glybera	NNP
cord-326960-9phlylce	181	2	(	(	-LRB-
cord-326960-9phlylce	181	3	alipogene	alipogene	NNP
cord-326960-9phlylce	181	4	tiparvovec	tiparvovec	NNP
cord-326960-9phlylce	181	5	)	)	-RRB-
cord-326960-9phlylce	181	6	is	be	VBZ
cord-326960-9phlylce	181	7	comprised	comprise	VBN
cord-326960-9phlylce	181	8	of	of	IN
cord-326960-9phlylce	181	9	the	the	DT
cord-326960-9phlylce	181	10	human	human	JJ
cord-326960-9phlylce	181	11	gene	gene	NN
cord-326960-9phlylce	181	12	LPL	LPL	NNP
cord-326960-9phlylce	181	13	S447X	S447X	NNP
cord-326960-9phlylce	181	14	in	in	IN
cord-326960-9phlylce	181	15	a	a	DT
cord-326960-9phlylce	181	16	BEVS	bevs	NN
cord-326960-9phlylce	181	17	-	-	HYPH
cord-326960-9phlylce	181	18	derived	derive	VBN
cord-326960-9phlylce	181	19	rAAV	raav	NN
cord-326960-9phlylce	181	20	serotype	serotype	NN
cord-326960-9phlylce	181	21	1	1	CD
cord-326960-9phlylce	181	22	vector	vector	NN
cord-326960-9phlylce	181	23	and	and	CC
cord-326960-9phlylce	181	24	is	be	VBZ
cord-326960-9phlylce	181	25	used	use	VBN
cord-326960-9phlylce	181	26	for	for	IN
cord-326960-9phlylce	181	27	the	the	DT
cord-326960-9phlylce	181	28	treatment	treatment	NN
cord-326960-9phlylce	181	29	of	of	IN
cord-326960-9phlylce	181	30	patients	patient	NNS
cord-326960-9phlylce	181	31	with	with	IN
cord-326960-9phlylce	181	32	lipoprotein	lipoprotein	NN
cord-326960-9phlylce	181	33	lipase	lipase	NNP
cord-326960-9phlylce	181	34	(	(	-LRB-
cord-326960-9phlylce	181	35	LPL	LPL	NNP
cord-326960-9phlylce	181	36	)	)	-RRB-
cord-326960-9phlylce	181	37	deficiency	deficiency	NN
cord-326960-9phlylce	181	38	[	[	-LRB-
cord-326960-9phlylce	181	39	66	66	CD
cord-326960-9phlylce	181	40	]	]	-RRB-
cord-326960-9phlylce	181	41	.	.	.
cord-326960-9phlylce	182	1	Clinical	clinical	JJ
cord-326960-9phlylce	182	2	studies	study	NNS
cord-326960-9phlylce	182	3	have	have	VBP
cord-326960-9phlylce	182	4	shown	show	VBN
cord-326960-9phlylce	182	5	Glybera	Glybera	NNP
cord-326960-9phlylce	182	6	to	to	TO
cord-326960-9phlylce	182	7	be	be	VB
cord-326960-9phlylce	182	8	safe	safe	JJ
cord-326960-9phlylce	182	9	and	and	CC
cord-326960-9phlylce	182	10	effective	effective	JJ
cord-326960-9phlylce	182	11	[	[	-LRB-
cord-326960-9phlylce	182	12	66	66	CD
cord-326960-9phlylce	182	13	,	,	,
cord-326960-9phlylce	182	14	67	67	CD
cord-326960-9phlylce	182	15	]	]	-RRB-
cord-326960-9phlylce	182	16	.	.	.
cord-326960-9phlylce	183	1	Glybera	Glybera	NNP
cord-326960-9phlylce	183	2	will	will	MD
cord-326960-9phlylce	183	3	likely	likely	RB
cord-326960-9phlylce	183	4	be	be	VB
cord-326960-9phlylce	183	5	the	the	DT
cord-326960-9phlylce	183	6	beginning	beginning	NN
cord-326960-9phlylce	183	7	when	when	WRB
cord-326960-9phlylce	183	8	it	-PRON-	PRP
cord-326960-9phlylce	183	9	comes	come	VBZ
cord-326960-9phlylce	183	10	to	to	IN
cord-326960-9phlylce	183	11	rAAV	raav	VB
cord-326960-9phlylce	183	12	-	-	HYPH
cord-326960-9phlylce	183	13	based	base	VBN
cord-326960-9phlylce	183	14	gene	gene	NN
cord-326960-9phlylce	183	15	therapy	therapy	NN
cord-326960-9phlylce	183	16	.	.	.
cord-326960-9phlylce	184	1	The	the	DT
cord-326960-9phlylce	184	2	approach	approach	NN
cord-326960-9phlylce	184	3	is	be	VBZ
cord-326960-9phlylce	184	4	relevant	relevant	JJ
cord-326960-9phlylce	184	5	to	to	IN
cord-326960-9phlylce	184	6	the	the	DT
cord-326960-9phlylce	184	7	estimated	estimate	VBN
cord-326960-9phlylce	184	8	thousands	thousand	NNS
cord-326960-9phlylce	184	9	of	of	IN
cord-326960-9phlylce	184	10	monogenic	monogenic	NNP
cord-326960-9phlylce	184	11	diseases	disease	NNS
cord-326960-9phlylce	184	12	[	[	-LRB-
cord-326960-9phlylce	184	13	68	68	CD
cord-326960-9phlylce	184	14	]	]	-RRB-
cord-326960-9phlylce	184	15	.	.	.
cord-326960-9phlylce	185	1	Treatments	treatment	NNS
cord-326960-9phlylce	185	2	are	be	VBP
cord-326960-9phlylce	185	3	actively	actively	RB
cord-326960-9phlylce	185	4	being	be	VBG
cord-326960-9phlylce	185	5	investigated	investigate	VBN
cord-326960-9phlylce	185	6	in	in	IN
cord-326960-9phlylce	185	7	a	a	DT
cord-326960-9phlylce	185	8	diverse	diverse	JJ
cord-326960-9phlylce	185	9	array	array	NN
cord-326960-9phlylce	185	10	of	of	IN
cord-326960-9phlylce	185	11	therapeutic	therapeutic	JJ
cord-326960-9phlylce	185	12	areas	area	NNS
cord-326960-9phlylce	185	13	and	and	CC
cord-326960-9phlylce	185	14	dozens	dozen	NNS
cord-326960-9phlylce	185	15	of	of	IN
cord-326960-9phlylce	185	16	product	product	NN
cord-326960-9phlylce	185	17	candidates	candidate	NNS
cord-326960-9phlylce	185	18	are	be	VBP
cord-326960-9phlylce	185	19	in	in	IN
cord-326960-9phlylce	185	20	clinical	clinical	JJ
cord-326960-9phlylce	185	21	development	development	NN
cord-326960-9phlylce	185	22	(	(	-LRB-
cord-326960-9phlylce	185	23	summarized	summarize	VBN
cord-326960-9phlylce	185	24	in	in	IN
cord-326960-9phlylce	185	25	Table	Table	NNP
cord-326960-9phlylce	185	26	2	2	CD
cord-326960-9phlylce	185	27	)	)	-RRB-
cord-326960-9phlylce	185	28	.	.	.
cord-326960-9phlylce	186	1	Hemophilia	Hemophilia	NNP
cord-326960-9phlylce	186	2	is	be	VBZ
cord-326960-9phlylce	186	3	one	one	CD
cord-326960-9phlylce	186	4	area	area	NN
cord-326960-9phlylce	186	5	where	where	WRB
cord-326960-9phlylce	186	6	progress	progress	NN
cord-326960-9phlylce	186	7	has	have	VBZ
cord-326960-9phlylce	186	8	been	be	VBN
cord-326960-9phlylce	186	9	made	make	VBN
cord-326960-9phlylce	186	10	(	(	-LRB-
cord-326960-9phlylce	186	11	reviewed	review	VBN
cord-326960-9phlylce	186	12	in	in	IN
cord-326960-9phlylce	186	13	[	[	-LRB-
cord-326960-9phlylce	186	14	69	69	CD
cord-326960-9phlylce	186	15	]	]	-RRB-
cord-326960-9phlylce	186	16	)	)	-RRB-
cord-326960-9phlylce	186	17	.	.	.
cord-326960-9phlylce	187	1	There	there	EX
cord-326960-9phlylce	187	2	are	be	VBP
cord-326960-9phlylce	187	3	four	four	CD
cord-326960-9phlylce	187	4	ongoing	ongoing	JJ
cord-326960-9phlylce	187	5	human	human	JJ
cord-326960-9phlylce	187	6	clinical	clinical	JJ
cord-326960-9phlylce	187	7	trials	trial	NNS
cord-326960-9phlylce	187	8	involving	involve	VBG
cord-326960-9phlylce	187	9	rAAV	rAAV	NNP
cord-326960-9phlylce	187	10	serotypes	serotypes	NNP
cord-326960-9phlylce	187	11	8	8	CD
cord-326960-9phlylce	187	12	or	or	CC
cord-326960-9phlylce	187	13	2	2	CD
cord-326960-9phlylce	187	14	,	,	,
cord-326960-9phlylce	187	15	all	all	DT
cord-326960-9phlylce	187	16	designed	design	VBN
cord-326960-9phlylce	187	17	to	to	TO
cord-326960-9phlylce	187	18	express	express	VB
cord-326960-9phlylce	187	19	factor	factor	NN
cord-326960-9phlylce	187	20	IX	IX	NNP
cord-326960-9phlylce	187	21	for	for	IN
cord-326960-9phlylce	187	22	the	the	DT
cord-326960-9phlylce	187	23	treatment	treatment	NN
cord-326960-9phlylce	187	24	of	of	IN
cord-326960-9phlylce	187	25	hemophilia	hemophilia	NN
cord-326960-9phlylce	187	26	B	B	NNP
cord-326960-9phlylce	187	27	(	(	-LRB-
cord-326960-9phlylce	187	28	Table	Table	NNP
cord-326960-9phlylce	187	29	2	2	CD
cord-326960-9phlylce	187	30	)	)	-RRB-
cord-326960-9phlylce	187	31	.	.	.
cord-326960-9phlylce	188	1	Factor	factor	NN
cord-326960-9phlylce	188	2	VIII	VIII	NNP
cord-326960-9phlylce	188	3	rAAV	rAAV	VBD
cord-326960-9phlylce	188	4	-	-	HYPH
cord-326960-9phlylce	188	5	based	base	VBN
cord-326960-9phlylce	188	6	therapy	therapy	NN
cord-326960-9phlylce	188	7	is	be	VBZ
cord-326960-9phlylce	188	8	a	a	DT
cord-326960-9phlylce	188	9	target	target	NN
cord-326960-9phlylce	188	10	for	for	IN
cord-326960-9phlylce	188	11	the	the	DT
cord-326960-9phlylce	188	12	treatment	treatment	NN
cord-326960-9phlylce	188	13	of	of	IN
cord-326960-9phlylce	188	14	hemophilia	hemophilia	NN
cord-326960-9phlylce	188	15	A	A	NNP
cord-326960-9phlylce	188	16	,	,	,
cord-326960-9phlylce	188	17	the	the	DT
cord-326960-9phlylce	188	18	most	most	RBS
cord-326960-9phlylce	188	19	common	common	JJ
cord-326960-9phlylce	188	20	severe	severe	JJ
cord-326960-9phlylce	188	21	inherited	inherit	VBN
cord-326960-9phlylce	188	22	bleeding	bleed	VBG
cord-326960-9phlylce	188	23	disorder	disorder	NN
cord-326960-9phlylce	188	24	,	,	,
cord-326960-9phlylce	188	25	and	and	CC
cord-326960-9phlylce	188	26	only	only	RB
cord-326960-9phlylce	188	27	a	a	DT
cord-326960-9phlylce	188	28	modest	modest	JJ
cord-326960-9phlylce	188	29	increase	increase	NN
cord-326960-9phlylce	188	30	in	in	IN
cord-326960-9phlylce	188	31	plasma	plasma	NN
cord-326960-9phlylce	188	32	factor	factor	NN
cord-326960-9phlylce	188	33	VIII	VIII	NNP
cord-326960-9phlylce	188	34	levels	level	NNS
cord-326960-9phlylce	188	35	is	be	VBZ
cord-326960-9phlylce	188	36	expected	expect	VBN
cord-326960-9phlylce	188	37	to	to	TO
cord-326960-9phlylce	188	38	be	be	VB
cord-326960-9phlylce	188	39	required	require	VBN
cord-326960-9phlylce	188	40	to	to	TO
cord-326960-9phlylce	188	41	be	be	VB
cord-326960-9phlylce	188	42	clinically	clinically	RB
cord-326960-9phlylce	188	43	relevant	relevant	JJ
cord-326960-9phlylce	188	44	[	[	-LRB-
cord-326960-9phlylce	188	45	69	69	CD
cord-326960-9phlylce	188	46	]	]	-RRB-
cord-326960-9phlylce	188	47	.	.	.
cord-326960-9phlylce	189	1	rAAV	rAAV	NNP
cord-326960-9phlylce	189	2	-	-	HYPH
cord-326960-9phlylce	189	3	based	base	VBN
cord-326960-9phlylce	189	4	treatments	treatment	NNS
cord-326960-9phlylce	189	5	for	for	IN
cord-326960-9phlylce	189	6	retinal	retinal	JJ
cord-326960-9phlylce	189	7	degeneration	degeneration	NN
cord-326960-9phlylce	189	8	,	,	,
cord-326960-9phlylce	189	9	including	include	VBG
cord-326960-9phlylce	189	10	macular	macular	JJ
cord-326960-9phlylce	189	11	degeneration	degeneration	NN
cord-326960-9phlylce	189	12	and	and	CC
cord-326960-9phlylce	189	13	Leber	Leber	NNP
cord-326960-9phlylce	189	14	's	's	POS
cord-326960-9phlylce	189	15	congenital	congenital	JJ
cord-326960-9phlylce	189	16	amaurosis	amaurosis	NN
cord-326960-9phlylce	189	17	type	type	NN
cord-326960-9phlylce	189	18	2	2	CD
cord-326960-9phlylce	189	19	,	,	,
cord-326960-9phlylce	189	20	are	be	VBP
cord-326960-9phlylce	189	21	another	another	DT
cord-326960-9phlylce	189	22	area	area	NN
cord-326960-9phlylce	189	23	of	of	IN
cord-326960-9phlylce	189	24	intense	intense	JJ
cord-326960-9phlylce	189	25	investigation	investigation	NN
cord-326960-9phlylce	189	26	[	[	-LRB-
cord-326960-9phlylce	189	27	70	70	CD
cord-326960-9phlylce	189	28	,	,	,
cord-326960-9phlylce	189	29	71	71	CD
cord-326960-9phlylce	189	30	]	]	-RRB-
cord-326960-9phlylce	189	31	.	.	.
cord-326960-9phlylce	190	1	Retinal	retinal	JJ
cord-326960-9phlylce	190	2	treatments	treatment	NNS
cord-326960-9phlylce	190	3	are	be	VBP
cord-326960-9phlylce	190	4	ideal	ideal	JJ
cord-326960-9phlylce	190	5	because	because	IN
cord-326960-9phlylce	190	6	of	of	IN
cord-326960-9phlylce	190	7	cell	cell	NN
cord-326960-9phlylce	190	8	accessibility	accessibility	NN
cord-326960-9phlylce	190	9	through	through	IN
cord-326960-9phlylce	190	10	intravitreal	intravitreal	NN
cord-326960-9phlylce	190	11	and	and	CC
cord-326960-9phlylce	190	12	subretinal	subretinal	JJ
cord-326960-9phlylce	190	13	injections	injection	NNS
cord-326960-9phlylce	190	14	and	and	CC
cord-326960-9phlylce	190	15	the	the	DT
cord-326960-9phlylce	190	16	ability	ability	NN
cord-326960-9phlylce	190	17	to	to	TO
cord-326960-9phlylce	190	18	assess	assess	VB
cord-326960-9phlylce	190	19	structure	structure	NN
cord-326960-9phlylce	190	20	and	and	CC
cord-326960-9phlylce	190	21	function	function	NN
cord-326960-9phlylce	190	22	noninvasively	noninvasively	RB
cord-326960-9phlylce	190	23	.	.	.
cord-326960-9phlylce	191	1	Serotype	Serotype	NNP
cord-326960-9phlylce	191	2	2	2	CD
cord-326960-9phlylce	191	3	is	be	VBZ
cord-326960-9phlylce	191	4	most	most	RBS
cord-326960-9phlylce	191	5	commonly	commonly	RB
cord-326960-9phlylce	191	6	used	use	VBN
cord-326960-9phlylce	191	7	for	for	IN
cord-326960-9phlylce	191	8	these	these	DT
cord-326960-9phlylce	191	9	therapies	therapy	NNS
cord-326960-9phlylce	191	10	but	but	CC
cord-326960-9phlylce	191	11	types	type	NNS
cord-326960-9phlylce	191	12	2	2	CD
cord-326960-9phlylce	191	13	,	,	,
cord-326960-9phlylce	191	14	5	5	CD
cord-326960-9phlylce	191	15	,	,	,
cord-326960-9phlylce	191	16	and	and	CC
cord-326960-9phlylce	191	17	7	7	CD
cord-326960-9phlylce	191	18	-	-	SYM
cord-326960-9phlylce	191	19	9	9	CD
cord-326960-9phlylce	191	20	are	be	VBP
cord-326960-9phlylce	191	21	all	all	DT
cord-326960-9phlylce	191	22	capable	capable	JJ
cord-326960-9phlylce	191	23	of	of	IN
cord-326960-9phlylce	191	24	infecting	infect	VBG
cord-326960-9phlylce	191	25	photoreceptors	photoreceptor	NNS
cord-326960-9phlylce	191	26	,	,	,
cord-326960-9phlylce	191	27	the	the	DT
cord-326960-9phlylce	191	28	most	most	RBS
cord-326960-9phlylce	191	29	prominent	prominent	JJ
cord-326960-9phlylce	191	30	cell	cell	NN
cord-326960-9phlylce	191	31	type	type	NN
cord-326960-9phlylce	191	32	for	for	IN
cord-326960-9phlylce	191	33	retinal	retinal	JJ
cord-326960-9phlylce	191	34	degenerations	degeneration	NNS
cord-326960-9phlylce	191	35	[	[	-LRB-
cord-326960-9phlylce	191	36	70	70	CD
cord-326960-9phlylce	191	37	]	]	-RRB-
cord-326960-9phlylce	191	38	.	.	.
cord-326960-9phlylce	192	1	Diseases	disease	NNS
cord-326960-9phlylce	192	2	of	of	IN
cord-326960-9phlylce	192	3	the	the	DT
cord-326960-9phlylce	192	4	central	central	JJ
cord-326960-9phlylce	192	5	nervous	nervous	JJ
cord-326960-9phlylce	192	6	system	system	NN
cord-326960-9phlylce	192	7	(	(	-LRB-
cord-326960-9phlylce	192	8	CNS	CNS	NNP
cord-326960-9phlylce	192	9	)	)	-RRB-
cord-326960-9phlylce	192	10	,	,	,
cord-326960-9phlylce	192	11	such	such	JJ
cord-326960-9phlylce	192	12	as	as	IN
cord-326960-9phlylce	192	13	Parkinson	Parkinson	NNP
cord-326960-9phlylce	192	14	's	's	POS
cord-326960-9phlylce	192	15	and	and	CC
cord-326960-9phlylce	192	16	Alzheimer	Alzheimer	NNP
cord-326960-9phlylce	192	17	's	's	POS
cord-326960-9phlylce	192	18	diseases	disease	NNS
cord-326960-9phlylce	192	19	,	,	,
cord-326960-9phlylce	192	20	are	be	VBP
cord-326960-9phlylce	192	21	also	also	RB
cord-326960-9phlylce	192	22	actively	actively	RB
cord-326960-9phlylce	192	23	being	be	VBG
cord-326960-9phlylce	192	24	tested	test	VBN
cord-326960-9phlylce	192	25	with	with	IN
cord-326960-9phlylce	192	26	rAAV	raav	NN
cord-326960-9phlylce	192	27	-	-	HYPH
cord-326960-9phlylce	192	28	based	base	VBN
cord-326960-9phlylce	192	29	therapies	therapy	NNS
cord-326960-9phlylce	192	30	that	that	WDT
cord-326960-9phlylce	192	31	are	be	VBP
cord-326960-9phlylce	192	32	promising	promise	VBG
cord-326960-9phlylce	192	33	.	.	.
cord-326960-9phlylce	193	1	AAVs	aav	NNS
cord-326960-9phlylce	193	2	exhibit	exhibit	VBP
cord-326960-9phlylce	193	3	a	a	DT
cord-326960-9phlylce	193	4	strong	strong	JJ
cord-326960-9phlylce	193	5	preference	preference	NN
cord-326960-9phlylce	193	6	for	for	IN
cord-326960-9phlylce	193	7	neuronal	neuronal	JJ
cord-326960-9phlylce	193	8	transduction	transduction	NN
cord-326960-9phlylce	193	9	,	,	,
cord-326960-9phlylce	193	10	making	make	VBG
cord-326960-9phlylce	193	11	them	-PRON-	PRP
cord-326960-9phlylce	193	12	a	a	DT
cord-326960-9phlylce	193	13	popular	popular	JJ
cord-326960-9phlylce	193	14	gene	gene	NN
cord-326960-9phlylce	193	15	delivery	delivery	NN
cord-326960-9phlylce	193	16	vehicle	vehicle	NN
cord-326960-9phlylce	193	17	for	for	IN
cord-326960-9phlylce	193	18	CNS	CNS	NNP
cord-326960-9phlylce	193	19	therapies	therapy	NNS
cord-326960-9phlylce	193	20	but	but	CC
cord-326960-9phlylce	193	21	vector	vector	NN
cord-326960-9phlylce	193	22	improvements	improvement	NNS
cord-326960-9phlylce	193	23	are	be	VBP
cord-326960-9phlylce	193	24	still	still	RB
cord-326960-9phlylce	193	25	needed	need	VBN
cord-326960-9phlylce	193	26	to	to	TO
cord-326960-9phlylce	193	27	optimize	optimize	VB
cord-326960-9phlylce	193	28	treatments	treatment	NNS
cord-326960-9phlylce	193	29	(	(	-LRB-
cord-326960-9phlylce	193	30	discussed	discuss	VBN
cord-326960-9phlylce	193	31	in	in	IN
cord-326960-9phlylce	193	32	[	[	-LRB-
cord-326960-9phlylce	193	33	72	72	CD
cord-326960-9phlylce	193	34	]	]	-RRB-
cord-326960-9phlylce	193	35	)	)	-RRB-
cord-326960-9phlylce	193	36	.	.	.
cord-326960-9phlylce	194	1	Final	final	JJ
cord-326960-9phlylce	194	2	-	-	HYPH
cord-326960-9phlylce	194	3	ly	ly	XX
cord-326960-9phlylce	194	4	,	,	,
cord-326960-9phlylce	194	5	Duchenne	Duchenne	NNP
cord-326960-9phlylce	194	6	muscular	muscular	JJ
cord-326960-9phlylce	194	7	dystrophy	dystrophy	NN
cord-326960-9phlylce	194	8	(	(	-LRB-
cord-326960-9phlylce	194	9	DMD	DMD	NNP
cord-326960-9phlylce	194	10	)	)	-RRB-
cord-326960-9phlylce	194	11	is	be	VBZ
cord-326960-9phlylce	194	12	a	a	DT
cord-326960-9phlylce	194	13	therapeutic	therapeutic	JJ
cord-326960-9phlylce	194	14	target	target	NN
cord-326960-9phlylce	194	15	where	where	WRB
cord-326960-9phlylce	194	16	progress	progress	NN
cord-326960-9phlylce	194	17	is	be	VBZ
cord-326960-9phlylce	194	18	being	be	VBG
cord-326960-9phlylce	194	19	made	make	VBN
cord-326960-9phlylce	194	20	.	.	.
cord-326960-9phlylce	195	1	Although	although	IN
cord-326960-9phlylce	195	2	the	the	DT
cord-326960-9phlylce	195	3	single	single	JJ
cord-326960-9phlylce	195	4	gene	gene	NN
cord-326960-9phlylce	195	5	affected	affect	VBN
cord-326960-9phlylce	195	6	in	in	IN
cord-326960-9phlylce	195	7	DMD	DMD	NNP
cord-326960-9phlylce	195	8	(	(	-LRB-
cord-326960-9phlylce	195	9	dystrophin	dystrophin	NN
cord-326960-9phlylce	195	10	)	)	-RRB-
cord-326960-9phlylce	195	11	has	have	VBZ
cord-326960-9phlylce	195	12	long	long	RB
cord-326960-9phlylce	195	13	been	be	VBN
cord-326960-9phlylce	195	14	known	know	VBN
cord-326960-9phlylce	195	15	,	,	,
cord-326960-9phlylce	195	16	its	-PRON-	PRP$
cord-326960-9phlylce	195	17	large	large	JJ
cord-326960-9phlylce	195	18	size	size	NN
cord-326960-9phlylce	195	19	has	have	VBZ
cord-326960-9phlylce	195	20	made	make	VBN
cord-326960-9phlylce	195	21	gene	gene	NN
cord-326960-9phlylce	195	22	therapy	therapy	NN
cord-326960-9phlylce	195	23	a	a	DT
cord-326960-9phlylce	195	24	challenge	challenge	NN
cord-326960-9phlylce	195	25	.	.	.
cord-326960-9phlylce	196	1	Recent	recent	JJ
cord-326960-9phlylce	196	2	treatment	treatment	NN
cord-326960-9phlylce	196	3	approaches	approach	VBZ
cord-326960-9phlylce	196	4	to	to	TO
cord-326960-9phlylce	196	5	overcome	overcome	VB
cord-326960-9phlylce	196	6	this	this	DT
cord-326960-9phlylce	196	7	include	include	VBP
cord-326960-9phlylce	196	8	exonskipping	exonskippe	VBG
cord-326960-9phlylce	196	9	,	,	,
cord-326960-9phlylce	196	10	trans	trans	NN
cord-326960-9phlylce	196	11	-	-	NN
cord-326960-9phlylce	196	12	splicing	splicing	JJ
cord-326960-9phlylce	196	13	and	and	CC
cord-326960-9phlylce	196	14	micro	micro	JJ
cord-326960-9phlylce	196	15	-	-	HYPH
cord-326960-9phlylce	196	16	and	and	CC
cord-326960-9phlylce	196	17	mini	mini	JJ
cord-326960-9phlylce	196	18	-	-	JJ
cord-326960-9phlylce	196	19	dystrophin	dystrophin	JJ
cord-326960-9phlylce	196	20	delivery	delivery	NN
cord-326960-9phlylce	196	21	strategies	strategy	NNS
cord-326960-9phlylce	196	22	[	[	-LRB-
cord-326960-9phlylce	196	23	53	53	CD
cord-326960-9phlylce	196	24	,	,	,
cord-326960-9phlylce	196	25	73	73	CD
cord-326960-9phlylce	196	26	]	]	-RRB-
cord-326960-9phlylce	196	27	.	.	.
cord-326960-9phlylce	197	1	For	for	IN
cord-326960-9phlylce	197	2	fifty	fifty	CD
cord-326960-9phlylce	197	3	years	year	NNS
cord-326960-9phlylce	197	4	influenza	influenza	NN
cord-326960-9phlylce	197	5	vaccine	vaccine	NN
cord-326960-9phlylce	197	6	manufacturing	manufacturing	NN
cord-326960-9phlylce	197	7	technology	technology	NN
cord-326960-9phlylce	197	8	remained	remain	VBD
cord-326960-9phlylce	197	9	largely	largely	RB
cord-326960-9phlylce	197	10	stagnant	stagnant	JJ
cord-326960-9phlylce	197	11	.	.	.
cord-326960-9phlylce	198	1	That	that	DT
cord-326960-9phlylce	198	2	changed	change	VBD
cord-326960-9phlylce	198	3	with	with	IN
cord-326960-9phlylce	198	4	the	the	DT
cord-326960-9phlylce	198	5	licensure	licensure	NN
cord-326960-9phlylce	198	6	of	of	IN
cord-326960-9phlylce	199	1	Flublok	Flublok	NNP
cord-326960-9phlylce	199	2	®	®	VBP
cord-326960-9phlylce	199	3	in	in	IN
cord-326960-9phlylce	199	4	2013	2013	CD
cord-326960-9phlylce	199	5	.	.	.
cord-326960-9phlylce	200	1	Flublok	Flublok	NNP
cord-326960-9phlylce	200	2	®	®	NNP
cord-326960-9phlylce	200	3	is	be	VBZ
cord-326960-9phlylce	200	4	a	a	DT
cord-326960-9phlylce	200	5	trivalent	trivalent	JJ
cord-326960-9phlylce	200	6	BEVS	bevs	NN
cord-326960-9phlylce	200	7	-	-	HYPH
cord-326960-9phlylce	200	8	derived	derive	VBN
cord-326960-9phlylce	200	9	vaccine	vaccine	NN
cord-326960-9phlylce	200	10	for	for	IN
cord-326960-9phlylce	200	11	seasonal	seasonal	JJ
cord-326960-9phlylce	200	12	influenza	influenza	NN
cord-326960-9phlylce	200	13	composed	compose	VBN
cord-326960-9phlylce	200	14	of	of	IN
cord-326960-9phlylce	200	15	135	135	CD
cord-326960-9phlylce	200	16	µg	µg	NNS
cord-326960-9phlylce	200	17	of	of	IN
cord-326960-9phlylce	200	18	recombinant	recombinant	JJ
cord-326960-9phlylce	200	19	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	200	20	(	(	-LRB-
cord-326960-9phlylce	200	21	HA	HA	NNP
cord-326960-9phlylce	200	22	)	)	-RRB-
cord-326960-9phlylce	200	23	derived	derive	VBN
cord-326960-9phlylce	200	24	from	from	IN
cord-326960-9phlylce	200	25	the	the	DT
cord-326960-9phlylce	200	26	two	two	CD
cord-326960-9phlylce	200	27	A	a	NN
cord-326960-9phlylce	200	28	and	and	CC
cord-326960-9phlylce	200	29	one	one	CD
cord-326960-9phlylce	200	30	B	b	NN
cord-326960-9phlylce	200	31	influenza	influenza	NN
cord-326960-9phlylce	200	32	viruses	virus	NNS
cord-326960-9phlylce	200	33	selected	select	VBN
cord-326960-9phlylce	200	34	for	for	IN
cord-326960-9phlylce	200	35	inclusion	inclusion	NN
cord-326960-9phlylce	200	36	in	in	IN
cord-326960-9phlylce	200	37	the	the	DT
cord-326960-9phlylce	200	38	annual	annual	JJ
cord-326960-9phlylce	200	39	influenza	influenza	NN
cord-326960-9phlylce	200	40	vaccine	vaccine	NN
cord-326960-9phlylce	200	41	by	by	IN
cord-326960-9phlylce	200	42	the	the	DT
cord-326960-9phlylce	200	43	World	World	NNP
cord-326960-9phlylce	200	44	Health	Health	NNP
cord-326960-9phlylce	200	45	Organization	Organization	NNP
cord-326960-9phlylce	200	46	;	;	:
cord-326960-9phlylce	200	47	the	the	DT
cord-326960-9phlylce	200	48	vaccine	vaccine	NN
cord-326960-9phlylce	200	49	is	be	VBZ
cord-326960-9phlylce	200	50	licensed	license	VBN
cord-326960-9phlylce	200	51	by	by	IN
cord-326960-9phlylce	200	52	the	the	DT
cord-326960-9phlylce	200	53	FDA	FDA	NNP
cord-326960-9phlylce	200	54	for	for	IN
cord-326960-9phlylce	200	55	adults	adult	NNS
cord-326960-9phlylce	200	56	18	18	CD
cord-326960-9phlylce	200	57	and	and	CC
cord-326960-9phlylce	200	58	older	old	JJR
cord-326960-9phlylce	200	59	[	[	-LRB-
cord-326960-9phlylce	200	60	74	74	CD
cord-326960-9phlylce	200	61	]	]	-RRB-
cord-326960-9phlylce	200	62	.	.	.
cord-326960-9phlylce	201	1	Influenza	influenza	NN
cord-326960-9phlylce	201	2	vaccines	vaccine	NNS
cord-326960-9phlylce	201	3	are	be	VBP
cord-326960-9phlylce	201	4	standardized	standardize	VBN
cord-326960-9phlylce	201	5	to	to	TO
cord-326960-9phlylce	201	6	contain	contain	VB
cord-326960-9phlylce	201	7	a	a	DT
cord-326960-9phlylce	201	8	specific	specific	JJ
cord-326960-9phlylce	201	9	amount	amount	NN
cord-326960-9phlylce	201	10	of	of	IN
cord-326960-9phlylce	201	11	HA	HA	NNP
cord-326960-9phlylce	201	12	,	,	,
cord-326960-9phlylce	201	13	the	the	DT
cord-326960-9phlylce	201	14	major	major	JJ
cord-326960-9phlylce	201	15	surface	surface	NN
cord-326960-9phlylce	201	16	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	201	17	on	on	IN
cord-326960-9phlylce	201	18	the	the	DT
cord-326960-9phlylce	201	19	influenza	influenza	NN
cord-326960-9phlylce	201	20	virus	virus	NN
cord-326960-9phlylce	201	21	[	[	-LRB-
cord-326960-9phlylce	201	22	17	17	CD
cord-326960-9phlylce	201	23	]	]	-RRB-
cord-326960-9phlylce	201	24	.	.	.
cord-326960-9phlylce	202	1	BEVS	bevs	NN
cord-326960-9phlylce	202	2	-	-	HYPH
cord-326960-9phlylce	202	3	derived	derive	VBN
cord-326960-9phlylce	202	4	recombinant	recombinant	JJ
cord-326960-9phlylce	202	5	HA	HA	NNP
cord-326960-9phlylce	202	6	forms	form	VBZ
cord-326960-9phlylce	202	7	trimers	trimer	NNS
cord-326960-9phlylce	202	8	that	that	IN
cord-326960-9phlylce	202	9	in	in	IN
cord-326960-9phlylce	202	10	turn	turn	NN
cord-326960-9phlylce	202	11	oligomerize	oligomerize	NNP
cord-326960-9phlylce	202	12	into	into	IN
cord-326960-9phlylce	202	13	immunogenic	immunogenic	JJ
cord-326960-9phlylce	202	14	rosettes	rosette	NNS
cord-326960-9phlylce	202	15	[	[	-LRB-
cord-326960-9phlylce	202	16	75	75	CD
cord-326960-9phlylce	202	17	]	]	-RRB-
cord-326960-9phlylce	202	18	.	.	.
cord-326960-9phlylce	203	1	These	these	DT
cord-326960-9phlylce	203	2	proteins	protein	NNS
cord-326960-9phlylce	203	3	can	can	MD
cord-326960-9phlylce	203	4	be	be	VB
cord-326960-9phlylce	203	5	purified	purify	VBN
cord-326960-9phlylce	203	6	to	to	IN
cord-326960-9phlylce	203	7	high	high	JJ
cord-326960-9phlylce	203	8	levels	level	NNS
cord-326960-9phlylce	203	9	resulting	result	VBG
cord-326960-9phlylce	203	10	in	in	IN
cord-326960-9phlylce	203	11	a	a	DT
cord-326960-9phlylce	203	12	vaccine	vaccine	NN
cord-326960-9phlylce	203	13	that	that	WDT
cord-326960-9phlylce	203	14	has	have	VBZ
cord-326960-9phlylce	203	15	been	be	VBN
cord-326960-9phlylce	203	16	shown	show	VBN
cord-326960-9phlylce	203	17	to	to	TO
cord-326960-9phlylce	203	18	be	be	VB
cord-326960-9phlylce	203	19	safe	safe	JJ
cord-326960-9phlylce	203	20	and	and	CC
cord-326960-9phlylce	203	21	effective	effective	JJ
cord-326960-9phlylce	203	22	in	in	IN
cord-326960-9phlylce	203	23	clinical	clinical	JJ
cord-326960-9phlylce	203	24	studies	study	NNS
cord-326960-9phlylce	203	25	[	[	-LRB-
cord-326960-9phlylce	203	26	5	5	CD
cord-326960-9phlylce	203	27	,	,	,
cord-326960-9phlylce	203	28	[	[	-LRB-
cord-326960-9phlylce	203	29	76	76	CD
cord-326960-9phlylce	203	30	]	]	-RRB-
cord-326960-9phlylce	203	31	[	[	-LRB-
cord-326960-9phlylce	203	32	77	77	CD
cord-326960-9phlylce	203	33	]	]	-RRB-
cord-326960-9phlylce	203	34	[	[	-LRB-
cord-326960-9phlylce	203	35	78	78	CD
cord-326960-9phlylce	203	36	]	]	-RRB-
cord-326960-9phlylce	203	37	[	[	-LRB-
cord-326960-9phlylce	203	38	79	79	CD
cord-326960-9phlylce	203	39	]	]	-RRB-
cord-326960-9phlylce	203	40	.	.	.
cord-326960-9phlylce	204	1	The	the	DT
cord-326960-9phlylce	204	2	advantages	advantage	NNS
cord-326960-9phlylce	204	3	of	of	IN
cord-326960-9phlylce	204	4	recombinant	recombinant	JJ
cord-326960-9phlylce	204	5	BEVS	BEVS	NNP
cord-326960-9phlylce	204	6	vaccines	vaccine	NNS
cord-326960-9phlylce	204	7	for	for	IN
cord-326960-9phlylce	204	8	pandemic	pandemic	NN
cord-326960-9phlylce	204	9	influenza	influenza	NN
cord-326960-9phlylce	204	10	are	be	VBP
cord-326960-9phlylce	204	11	especially	especially	RB
cord-326960-9phlylce	204	12	important	important	JJ
cord-326960-9phlylce	204	13	.	.	.
cord-326960-9phlylce	205	1	Vaccines	vaccine	NNS
cord-326960-9phlylce	205	2	for	for	IN
cord-326960-9phlylce	205	3	avian	avian	JJ
cord-326960-9phlylce	205	4	influenza	influenza	NN
cord-326960-9phlylce	205	5	viruses	virus	NNS
cord-326960-9phlylce	205	6	such	such	JJ
cord-326960-9phlylce	205	7	as	as	IN
cord-326960-9phlylce	205	8	the	the	DT
cord-326960-9phlylce	205	9	H5	H5	NNP
cord-326960-9phlylce	205	10	,	,	,
cord-326960-9phlylce	205	11	H7	H7	NNP
cord-326960-9phlylce	205	12	and	and	CC
cord-326960-9phlylce	205	13	H2	H2	NNP
cord-326960-9phlylce	205	14	subtypes	subtype	NNS
cord-326960-9phlylce	205	15	are	be	VBP
cord-326960-9phlylce	205	16	urgently	urgently	RB
cord-326960-9phlylce	205	17	needed	need	VBN
cord-326960-9phlylce	205	18	because	because	IN
cord-326960-9phlylce	205	19	of	of	IN
cord-326960-9phlylce	205	20	these	these	DT
cord-326960-9phlylce	205	21	viruses	virus	NNS
cord-326960-9phlylce	205	22	'	'	POS
cord-326960-9phlylce	205	23	high	high	JJ
cord-326960-9phlylce	205	24	pathogenicity	pathogenicity	NN
cord-326960-9phlylce	205	25	and	and	CC
cord-326960-9phlylce	205	26	mortality	mortality	NN
cord-326960-9phlylce	205	27	rates	rate	NNS
cord-326960-9phlylce	205	28	in	in	IN
cord-326960-9phlylce	205	29	humans	human	NNS
cord-326960-9phlylce	205	30	and	and	CC
cord-326960-9phlylce	205	31	the	the	DT
cord-326960-9phlylce	205	32	fact	fact	NN
cord-326960-9phlylce	205	33	that	that	IN
cord-326960-9phlylce	205	34	H2	H2	NNP
cord-326960-9phlylce	205	35	has	have	VBZ
cord-326960-9phlylce	205	36	previously	previously	RB
cord-326960-9phlylce	205	37	demonstrated	demonstrate	VBN
cord-326960-9phlylce	205	38	pandemic	pandemic	JJ
cord-326960-9phlylce	205	39	potential	potential	JJ
cord-326960-9phlylce	205	40	and	and	CC
cord-326960-9phlylce	205	41	human	human	NN
cord-326960-9phlylce	205	42	-	-	HYPH
cord-326960-9phlylce	205	43	to	to	IN
cord-326960-9phlylce	205	44	-	-	HYPH
cord-326960-9phlylce	205	45	human	human	JJ
cord-326960-9phlylce	205	46	transmissibility	transmissibility	NN
cord-326960-9phlylce	205	47	[	[	-LRB-
cord-326960-9phlylce	205	48	80	80	CD
cord-326960-9phlylce	205	49	,	,	,
cord-326960-9phlylce	205	50	81	81	CD
cord-326960-9phlylce	205	51	]	]	-RRB-
cord-326960-9phlylce	205	52	.	.	.
cord-326960-9phlylce	206	1	A	a	DT
cord-326960-9phlylce	206	2	monovalent	monovalent	JJ
cord-326960-9phlylce	206	3	variation	variation	NN
cord-326960-9phlylce	206	4	of	of	IN
cord-326960-9phlylce	206	5	the	the	DT
cord-326960-9phlylce	206	6	Flublok	Flublok	NNP
cord-326960-9phlylce	206	7	®	®	POS
cord-326960-9phlylce	206	8	vaccine	vaccine	NN
cord-326960-9phlylce	206	9	called	call	VBN
cord-326960-9phlylce	206	10	Panblok	Panblok	NNP
cord-326960-9phlylce	206	11	®	®	VBP
cord-326960-9phlylce	206	12	has	have	VBZ
cord-326960-9phlylce	206	13	been	be	VBN
cord-326960-9phlylce	206	14	developed	develop	VBN
cord-326960-9phlylce	206	15	.	.	.
cord-326960-9phlylce	207	1	In	in	IN
cord-326960-9phlylce	207	2	a	a	DT
cord-326960-9phlylce	207	3	Phase	Phase	NNP
cord-326960-9phlylce	207	4	II	II	NNP
cord-326960-9phlylce	207	5	study	study	NN
cord-326960-9phlylce	207	6	of	of	IN
cord-326960-9phlylce	207	7	H5	H5	NNP
cord-326960-9phlylce	207	8	Panblok	Panblok	NNP
cord-326960-9phlylce	207	9	®	®	.
cord-326960-9phlylce	207	10	(	(	-LRB-
cord-326960-9phlylce	207	11	A	a	NN
cord-326960-9phlylce	207	12	/	/	,
cord-326960-9phlylce	207	13	Indonesia/5/05	indonesia/5/05	NN
cord-326960-9phlylce	207	14	)	)	-RRB-
cord-326960-9phlylce	207	15	,	,	,
cord-326960-9phlylce	207	16	a	a	DT
cord-326960-9phlylce	207	17	two	two	CD
cord-326960-9phlylce	207	18	-	-	HYPH
cord-326960-9phlylce	207	19	dose	dose	NN
cord-326960-9phlylce	207	20	schedule	schedule	NN
cord-326960-9phlylce	207	21	of	of	IN
cord-326960-9phlylce	207	22	vaccine	vaccine	NN
cord-326960-9phlylce	207	23	at	at	IN
cord-326960-9phlylce	207	24	doses	dose	NNS
cord-326960-9phlylce	207	25	of	of	IN
cord-326960-9phlylce	207	26	3.8	3.8	CD
cord-326960-9phlylce	207	27	-	-	SYM
cord-326960-9phlylce	207	28	45	45	CD
cord-326960-9phlylce	207	29	µg	µg	IN
cord-326960-9phlylce	207	30	HA	HA	NNP
cord-326960-9phlylce	207	31	formulated	formulate	VBN
cord-326960-9phlylce	207	32	with	with	IN
cord-326960-9phlylce	207	33	the	the	DT
cord-326960-9phlylce	207	34	adjuvant	adjuvant	JJ
cord-326960-9phlylce	207	35	glucopyranosyl	glucopyranosyl	NN
cord-326960-9phlylce	207	36	lipid	lipid	NN
cord-326960-9phlylce	207	37	A	A	NNP
cord-326960-9phlylce	207	38	/	/	SYM
cord-326960-9phlylce	207	39	stable	stable	JJ
cord-326960-9phlylce	207	40	emulsion	emulsion	NN
cord-326960-9phlylce	207	41	(	(	-LRB-
cord-326960-9phlylce	207	42	GLA	GLA	NNP
cord-326960-9phlylce	207	43	/	/	SYM
cord-326960-9phlylce	207	44	SE	SE	NNP
cord-326960-9phlylce	207	45	)	)	-RRB-
cord-326960-9phlylce	207	46	had	have	VBD
cord-326960-9phlylce	207	47	an	an	DT
cord-326960-9phlylce	207	48	acceptable	acceptable	JJ
cord-326960-9phlylce	207	49	safety	safety	NN
cord-326960-9phlylce	207	50	and	and	CC
cord-326960-9phlylce	207	51	reactogenicity	reactogenicity	NN
cord-326960-9phlylce	207	52	profile	profile	NN
cord-326960-9phlylce	207	53	and	and	CC
cord-326960-9phlylce	207	54	elicited	elicit	VBD
cord-326960-9phlylce	207	55	serologic	serologic	JJ
cord-326960-9phlylce	207	56	responses	response	NNS
cord-326960-9phlylce	207	57	meeting	meet	VBG
cord-326960-9phlylce	207	58	seroconversion	seroconversion	NN
cord-326960-9phlylce	207	59	criteria	criterion	NNS
cord-326960-9phlylce	207	60	in	in	IN
cord-326960-9phlylce	207	61	adults	adult	NNS
cord-326960-9phlylce	207	62	18	18	CD
cord-326960-9phlylce	207	63	-	-	SYM
cord-326960-9phlylce	207	64	49	49	CD
cord-326960-9phlylce	207	65	years	year	NNS
cord-326960-9phlylce	207	66	old	old	JJ
cord-326960-9phlylce	207	67	[	[	-LRB-
cord-326960-9phlylce	207	68	82	82	CD
cord-326960-9phlylce	207	69	]	]	-RRB-
cord-326960-9phlylce	207	70	.	.	.
cord-326960-9phlylce	208	1	Moreover	moreover	RB
cord-326960-9phlylce	208	2	,	,	,
cord-326960-9phlylce	208	3	an	an	DT
cord-326960-9phlylce	208	4	earlier	early	JJR
cord-326960-9phlylce	208	5	study	study	NN
cord-326960-9phlylce	208	6	showed	show	VBD
cord-326960-9phlylce	208	7	that	that	IN
cord-326960-9phlylce	208	8	people	people	NNS
cord-326960-9phlylce	208	9	administered	administer	VBD
cord-326960-9phlylce	208	10	H5	H5	NNP
cord-326960-9phlylce	208	11	Panblok	Panblok	NNP
cord-326960-9phlylce	208	12	®	®	.
cord-326960-9phlylce	208	13	(	(	-LRB-
cord-326960-9phlylce	208	14	A	A	NNP
cord-326960-9phlylce	208	15	/	/	SYM
cord-326960-9phlylce	208	16	Hong	Hong	NNP
cord-326960-9phlylce	208	17	Kong/156/1997	Kong/156/1997	NNP
cord-326960-9phlylce	208	18	)	)	-RRB-
cord-326960-9phlylce	208	19	in	in	IN
cord-326960-9phlylce	208	20	1998	1998	CD
cord-326960-9phlylce	208	21	were	be	VBD
cord-326960-9phlylce	208	22	primed	prime	VBN
cord-326960-9phlylce	208	23	for	for	IN
cord-326960-9phlylce	208	24	an	an	DT
cord-326960-9phlylce	208	25	enhanced	enhance	VBN
cord-326960-9phlylce	208	26	immune	immune	JJ
cord-326960-9phlylce	208	27	response	response	NN
cord-326960-9phlylce	208	28	following	follow	VBG
cord-326960-9phlylce	208	29	administration	administration	NN
cord-326960-9phlylce	208	30	of	of	IN
cord-326960-9phlylce	208	31	an	an	DT
cord-326960-9phlylce	208	32	antigenically	antigenically	RB
cord-326960-9phlylce	208	33	variant	variant	JJ
cord-326960-9phlylce	208	34	vaccine	vaccine	NN
cord-326960-9phlylce	208	35	strain	strain	NN
cord-326960-9phlylce	208	36	in	in	IN
cord-326960-9phlylce	208	37	2006	2006	CD
cord-326960-9phlylce	208	38	[	[	-LRB-
cord-326960-9phlylce	208	39	83	83	CD
cord-326960-9phlylce	208	40	]	]	-RRB-
cord-326960-9phlylce	208	41	.	.	.
cord-326960-9phlylce	209	1	evaluated	evaluate	VBD
cord-326960-9phlylce	209	2	a	a	DT
cord-326960-9phlylce	209	3	different	different	JJ
cord-326960-9phlylce	209	4	BEVS	bevs	NN
cord-326960-9phlylce	209	5	-	-	HYPH
cord-326960-9phlylce	209	6	derived	derive	VBN
cord-326960-9phlylce	209	7	H5	H5	NNP
cord-326960-9phlylce	209	8	subunit	subunit	NN
cord-326960-9phlylce	209	9	vaccine	vaccine	NN
cord-326960-9phlylce	209	10	candidate	candidate	NN
cord-326960-9phlylce	209	11	(	(	-LRB-
cord-326960-9phlylce	209	12	A	a	NN
cord-326960-9phlylce	209	13	/	/	SYM
cord-326960-9phlylce	209	14	goose	goose	NN
cord-326960-9phlylce	209	15	/	/	SYM
cord-326960-9phlylce	209	16	Guangdong/1/96	guangdong/1/96	NN
cord-326960-9phlylce	209	17	)	)	-RRB-
cord-326960-9phlylce	209	18	and	and	CC
cord-326960-9phlylce	209	19	showed	show	VBD
cord-326960-9phlylce	209	20	that	that	IN
cord-326960-9phlylce	209	21	it	-PRON-	PRP
cord-326960-9phlylce	209	22	protected	protect	VBD
cord-326960-9phlylce	209	23	against	against	IN
cord-326960-9phlylce	209	24	a	a	DT
cord-326960-9phlylce	209	25	lethal	lethal	JJ
cord-326960-9phlylce	209	26	challenge	challenge	NN
cord-326960-9phlylce	209	27	in	in	IN
cord-326960-9phlylce	209	28	BALB	BALB	NNP
cord-326960-9phlylce	209	29	/	/	SYM
cord-326960-9phlylce	209	30	c	c	NN
cord-326960-9phlylce	209	31	mice	mouse	NNS
cord-326960-9phlylce	209	32	and	and	CC
cord-326960-9phlylce	209	33	in	in	IN
cord-326960-9phlylce	209	34	specific	specific	JJ
cord-326960-9phlylce	209	35	pathogen	pathogen	NN
cord-326960-9phlylce	209	36	-	-	HYPH
cord-326960-9phlylce	209	37	free	free	JJ
cord-326960-9phlylce	209	38	and	and	CC
cord-326960-9phlylce	209	39	commercial	commercial	JJ
cord-326960-9phlylce	209	40	chickens	chicken	NNS
cord-326960-9phlylce	209	41	,	,	,
cord-326960-9phlylce	209	42	suggesting	suggest	VBG
cord-326960-9phlylce	209	43	it	-PRON-	PRP
cord-326960-9phlylce	209	44	could	could	MD
cord-326960-9phlylce	209	45	be	be	VB
cord-326960-9phlylce	209	46	useful	useful	JJ
cord-326960-9phlylce	209	47	as	as	IN
cord-326960-9phlylce	209	48	both	both	CC
cord-326960-9phlylce	209	49	a	a	DT
cord-326960-9phlylce	209	50	human	human	JJ
cord-326960-9phlylce	209	51	and	and	CC
cord-326960-9phlylce	209	52	animal	animal	NN
cord-326960-9phlylce	209	53	vaccine	vaccine	NN
cord-326960-9phlylce	209	54	[	[	-LRB-
cord-326960-9phlylce	209	55	84	84	CD
cord-326960-9phlylce	209	56	]	]	-RRB-
cord-326960-9phlylce	209	57	.	.	.
cord-326960-9phlylce	210	1	Multi	multi	JJ
cord-326960-9phlylce	210	2	-	-	JJ
cord-326960-9phlylce	210	3	component	component	NN
cord-326960-9phlylce	210	4	VLP	VLP	NNP
cord-326960-9phlylce	210	5	vaccines	vaccine	NNS
cord-326960-9phlylce	210	6	for	for	IN
cord-326960-9phlylce	210	7	pandemic	pandemic	NN
cord-326960-9phlylce	210	8	influenza	influenza	NN
cord-326960-9phlylce	210	9	are	be	VBP
cord-326960-9phlylce	210	10	under	under	IN
cord-326960-9phlylce	210	11	development	development	NN
cord-326960-9phlylce	210	12	that	that	WDT
cord-326960-9phlylce	210	13	are	be	VBP
cord-326960-9phlylce	210	14	composed	compose	VBN
cord-326960-9phlylce	210	15	of	of	IN
cord-326960-9phlylce	210	16	recombinant	recombinant	JJ
cord-326960-9phlylce	210	17	HA	HA	NNP
cord-326960-9phlylce	210	18	,	,	,
cord-326960-9phlylce	210	19	neuraminidase	neuraminidase	FW
cord-326960-9phlylce	210	20	(	(	-LRB-
cord-326960-9phlylce	210	21	NA	NA	NNP
cord-326960-9phlylce	210	22	)	)	-RRB-
cord-326960-9phlylce	210	23	and	and	CC
cord-326960-9phlylce	210	24	matrix	matrix	NN
cord-326960-9phlylce	210	25	1	1	CD
cord-326960-9phlylce	210	26	(	(	-LRB-
cord-326960-9phlylce	210	27	M1	M1	NNP
cord-326960-9phlylce	210	28	)	)	-RRB-
cord-326960-9phlylce	210	29	proteins	protein	NNS
cord-326960-9phlylce	210	30	produced	produce	VBN
cord-326960-9phlylce	210	31	in	in	IN
cord-326960-9phlylce	210	32	Sf-9	Sf-9	NNP
cord-326960-9phlylce	210	33	cells	cell	NNS
cord-326960-9phlylce	210	34	[	[	-LRB-
cord-326960-9phlylce	210	35	85	85	CD
cord-326960-9phlylce	210	36	]	]	-RRB-
cord-326960-9phlylce	210	37	[	[	-LRB-
cord-326960-9phlylce	210	38	86	86	CD
cord-326960-9phlylce	210	39	]	]	-RRB-
cord-326960-9phlylce	210	40	[	[	-LRB-
cord-326960-9phlylce	210	41	87	87	CD
cord-326960-9phlylce	210	42	]	]	-RRB-
cord-326960-9phlylce	210	43	.	.	.
cord-326960-9phlylce	211	1	Evaluation	evaluation	NN
cord-326960-9phlylce	211	2	of	of	IN
cord-326960-9phlylce	211	3	an	an	DT
cord-326960-9phlylce	211	4	H5N1	H5N1	NNP
cord-326960-9phlylce	211	5	(	(	-LRB-
cord-326960-9phlylce	211	6	A	a	NN
cord-326960-9phlylce	211	7	/	/	SYM
cord-326960-9phlylce	211	8	Indonesia/5/05	indonesia/5/05	NN
cord-326960-9phlylce	211	9	)	)	-RRB-
cord-326960-9phlylce	211	10	VLP	VLP	NNP
cord-326960-9phlylce	211	11	vaccine	vaccine	NN
cord-326960-9phlylce	211	12	in	in	IN
cord-326960-9phlylce	211	13	a	a	DT
cord-326960-9phlylce	211	14	Phase	phase	NN
cord-326960-9phlylce	211	15	I	I	NNP
cord-326960-9phlylce	211	16	/	/	SYM
cord-326960-9phlylce	211	17	II	II	NNP
cord-326960-9phlylce	211	18	study	study	NN
cord-326960-9phlylce	211	19	of	of	IN
cord-326960-9phlylce	211	20	adults	adult	NNS
cord-326960-9phlylce	211	21	18	18	CD
cord-326960-9phlylce	211	22	-	-	SYM
cord-326960-9phlylce	211	23	40	40	CD
cord-326960-9phlylce	211	24	years	year	NNS
cord-326960-9phlylce	211	25	old	old	JJ
cord-326960-9phlylce	211	26	showed	show	VBD
cord-326960-9phlylce	211	27	that	that	IN
cord-326960-9phlylce	211	28	two	two	CD
cord-326960-9phlylce	211	29	doses	dose	NNS
cord-326960-9phlylce	211	30	of	of	IN
cord-326960-9phlylce	211	31	unadjuvanted	unadjuvanted	JJ
cord-326960-9phlylce	211	32	vaccine	vaccine	NN
cord-326960-9phlylce	211	33	at	at	IN
cord-326960-9phlylce	211	34	15	15	CD
cord-326960-9phlylce	211	35	,	,	,
cord-326960-9phlylce	211	36	45	45	CD
cord-326960-9phlylce	211	37	or	or	CC
cord-326960-9phlylce	211	38	90	90	CD
cord-326960-9phlylce	211	39	µg	µg	NN
cord-326960-9phlylce	211	40	HA	HA	NNP
cord-326960-9phlylce	211	41	/	/	SYM
cord-326960-9phlylce	211	42	dose	dose	NN
cord-326960-9phlylce	211	43	were	be	VBD
cord-326960-9phlylce	211	44	generally	generally	RB
cord-326960-9phlylce	211	45	well	well	RB
cord-326960-9phlylce	211	46	-	-	HYPH
cord-326960-9phlylce	211	47	tolerated	tolerate	VBN
cord-326960-9phlylce	211	48	and	and	CC
cord-326960-9phlylce	211	49	resulted	result	VBD
cord-326960-9phlylce	211	50	in	in	IN
cord-326960-9phlylce	211	51	seroconversion	seroconversion	NN
cord-326960-9phlylce	211	52	[	[	-LRB-
cord-326960-9phlylce	211	53	85	85	CD
cord-326960-9phlylce	211	54	]	]	-RRB-
cord-326960-9phlylce	211	55	.	.	.
cord-326960-9phlylce	212	1	Similarly	similarly	RB
cord-326960-9phlylce	212	2	,	,	,
cord-326960-9phlylce	212	3	a	a	DT
cord-326960-9phlylce	212	4	Phase	Phase	NNP
cord-326960-9phlylce	212	5	II	II	NNP
cord-326960-9phlylce	212	6	study	study	NN
cord-326960-9phlylce	212	7	of	of	IN
cord-326960-9phlylce	212	8	an	an	DT
cord-326960-9phlylce	212	9	H1N1	H1N1	NNP
cord-326960-9phlylce	212	10	(	(	-LRB-
cord-326960-9phlylce	212	11	A	A	NNP
cord-326960-9phlylce	212	12	/	/	SYM
cord-326960-9phlylce	212	13	California/04/2009	California/04/2009	NNP
cord-326960-9phlylce	212	14	)	)	-RRB-
cord-326960-9phlylce	212	15	VLP	VLP	NNP
cord-326960-9phlylce	212	16	vaccine	vaccine	NN
cord-326960-9phlylce	212	17	in	in	IN
cord-326960-9phlylce	212	18	adults	adult	NNS
cord-326960-9phlylce	212	19	18	18	CD
cord-326960-9phlylce	212	20	-	-	SYM
cord-326960-9phlylce	212	21	64	64	CD
cord-326960-9phlylce	212	22	years	year	NNS
cord-326960-9phlylce	212	23	old	old	JJ
cord-326960-9phlylce	212	24	showed	show	VBD
cord-326960-9phlylce	212	25	it	-PRON-	PRP
cord-326960-9phlylce	212	26	was	be	VBD
cord-326960-9phlylce	212	27	safe	safe	JJ
cord-326960-9phlylce	212	28	at	at	IN
cord-326960-9phlylce	212	29	doses	dose	NNS
cord-326960-9phlylce	212	30	of	of	IN
cord-326960-9phlylce	212	31	5	5	CD
cord-326960-9phlylce	212	32	,	,	,
cord-326960-9phlylce	212	33	15	15	CD
cord-326960-9phlylce	212	34	or	or	CC
cord-326960-9phlylce	212	35	45	45	CD
cord-326960-9phlylce	212	36	µg	µg	NN
cord-326960-9phlylce	213	1	HA	HA	NNP
cord-326960-9phlylce	213	2	/	/	SYM
cord-326960-9phlylce	213	3	dose	dose	NN
cord-326960-9phlylce	213	4	and	and	CC
cord-326960-9phlylce	213	5	elicited	elicit	VBD
cord-326960-9phlylce	213	6	high	high	JJ
cord-326960-9phlylce	213	7	rates	rate	NNS
cord-326960-9phlylce	213	8	of	of	IN
cord-326960-9phlylce	213	9	seroprotection	seroprotection	NN
cord-326960-9phlylce	213	10	(	(	-LRB-
cord-326960-9phlylce	213	11	82	82	CD
cord-326960-9phlylce	213	12	-	-	SYM
cord-326960-9phlylce	213	13	92	92	CD
cord-326960-9phlylce	213	14	%	%	NN
cord-326960-9phlylce	213	15	)	)	-RRB-
cord-326960-9phlylce	214	1	[	[	-LRB-
cord-326960-9phlylce	214	2	86	86	CD
cord-326960-9phlylce	214	3	]	]	-RRB-
cord-326960-9phlylce	214	4	.	.	.
cord-326960-9phlylce	215	1	More	more	RBR
cord-326960-9phlylce	215	2	recently	recently	RB
cord-326960-9phlylce	215	3	,	,	,
cord-326960-9phlylce	215	4	an	an	DT
cord-326960-9phlylce	215	5	H7N9	H7N9	NNP
cord-326960-9phlylce	215	6	VLP	VLP	NNP
cord-326960-9phlylce	215	7	vaccine	vaccine	NN
cord-326960-9phlylce	215	8	was	be	VBD
cord-326960-9phlylce	215	9	developed	develop	VBN
cord-326960-9phlylce	215	10	that	that	WDT
cord-326960-9phlylce	215	11	was	be	VBD
cord-326960-9phlylce	215	12	comprised	comprise	VBN
cord-326960-9phlylce	215	13	of	of	IN
cord-326960-9phlylce	215	14	HA	HA	NNP
cord-326960-9phlylce	215	15	and	and	CC
cord-326960-9phlylce	215	16	NA	NA	NNP
cord-326960-9phlylce	215	17	proteins	protein	NNS
cord-326960-9phlylce	215	18	matched	match	VBN
cord-326960-9phlylce	215	19	to	to	IN
cord-326960-9phlylce	215	20	A	a	NN
cord-326960-9phlylce	215	21	/	/	SYM
cord-326960-9phlylce	215	22	Anhui/1/2013	anhui/1/2013	NN
cord-326960-9phlylce	215	23	(	(	-LRB-
cord-326960-9phlylce	215	24	H7N9	H7N9	NNP
cord-326960-9phlylce	215	25	)	)	-RRB-
cord-326960-9phlylce	215	26	and	and	CC
cord-326960-9phlylce	215	27	M1	M1	NNP
cord-326960-9phlylce	215	28	protein	protein	NN
cord-326960-9phlylce	215	29	matched	match	VBN
cord-326960-9phlylce	215	30	to	to	IN
cord-326960-9phlylce	215	31	A	A	NNP
cord-326960-9phlylce	215	32	/	/	SYM
cord-326960-9phlylce	215	33	Indonesia/05/2005	Indonesia/05/2005	NNP
cord-326960-9phlylce	215	34	(	(	-LRB-
cord-326960-9phlylce	215	35	H5N1	H5N1	NNP
cord-326960-9phlylce	215	36	)	)	-RRB-
cord-326960-9phlylce	216	1	[	[	-LRB-
cord-326960-9phlylce	216	2	87	87	CD
cord-326960-9phlylce	216	3	]	]	-RRB-
cord-326960-9phlylce	216	4	.	.	.
cord-326960-9phlylce	217	1	This	this	DT
cord-326960-9phlylce	217	2	vaccine	vaccine	NN
cord-326960-9phlylce	217	3	candidate	candidate	NN
cord-326960-9phlylce	217	4	was	be	VBD
cord-326960-9phlylce	217	5	tested	test	VBN
cord-326960-9phlylce	217	6	with	with	IN
cord-326960-9phlylce	217	7	or	or	CC
cord-326960-9phlylce	217	8	without	without	IN
cord-326960-9phlylce	217	9	saponin	saponin	NN
cord-326960-9phlylce	217	10	-	-	HYPH
cord-326960-9phlylce	217	11	based	base	VBN
cord-326960-9phlylce	217	12	ISCOMATRIX	ISCOMATRIX	NNP
cord-326960-9phlylce	217	13	adjuvant	adjuvant	NN
cord-326960-9phlylce	217	14	in	in	IN
cord-326960-9phlylce	217	15	BALB	BALB	NNP
cord-326960-9phlylce	217	16	/	/	SYM
cord-326960-9phlylce	217	17	c	c	NN
cord-326960-9phlylce	217	18	mice	mouse	NNS
cord-326960-9phlylce	217	19	and	and	CC
cord-326960-9phlylce	217	20	was	be	VBD
cord-326960-9phlylce	217	21	shown	show	VBN
cord-326960-9phlylce	217	22	to	to	TO
cord-326960-9phlylce	217	23	protect	protect	VB
cord-326960-9phlylce	217	24	against	against	IN
cord-326960-9phlylce	217	25	a	a	DT
cord-326960-9phlylce	217	26	lethal	lethal	JJ
cord-326960-9phlylce	217	27	challenge	challenge	NN
cord-326960-9phlylce	217	28	.	.	.
cord-326960-9phlylce	218	1	Antibodies	antibody	NNS
cord-326960-9phlylce	218	2	against	against	IN
cord-326960-9phlylce	218	3	both	both	CC
cord-326960-9phlylce	218	4	HA	HA	NNP
cord-326960-9phlylce	218	5	and	and	CC
cord-326960-9phlylce	218	6	NA	NA	NNP
cord-326960-9phlylce	218	7	were	be	VBD
cord-326960-9phlylce	218	8	elicited	elicit	VBN
cord-326960-9phlylce	218	9	,	,	,
cord-326960-9phlylce	218	10	with	with	IN
cord-326960-9phlylce	218	11	3-to	3-to	CD
cord-326960-9phlylce	218	12	4-fold	4-fold	CD
cord-326960-9phlylce	218	13	higher	high	JJR
cord-326960-9phlylce	218	14	responses	response	NNS
cord-326960-9phlylce	218	15	in	in	IN
cord-326960-9phlylce	218	16	the	the	DT
cord-326960-9phlylce	218	17	ISCOMATRIX	ISCOMATRIX	NNP
cord-326960-9phlylce	218	18	groups	group	NNS
cord-326960-9phlylce	218	19	.	.	.
cord-326960-9phlylce	219	1	Although	although	IN
cord-326960-9phlylce	219	2	the	the	DT
cord-326960-9phlylce	219	3	data	datum	NNS
cord-326960-9phlylce	219	4	are	be	VBP
cord-326960-9phlylce	219	5	promising	promise	VBG
cord-326960-9phlylce	219	6	,	,	,
cord-326960-9phlylce	219	7	a	a	DT
cord-326960-9phlylce	219	8	challenge	challenge	NN
cord-326960-9phlylce	219	9	for	for	IN
cord-326960-9phlylce	219	10	the	the	DT
cord-326960-9phlylce	219	11	development	development	NN
cord-326960-9phlylce	219	12	of	of	IN
cord-326960-9phlylce	219	13	multi	multi	JJ
cord-326960-9phlylce	219	14	-	-	JJ
cord-326960-9phlylce	219	15	component	component	NN
cord-326960-9phlylce	219	16	VLP	VLP	NNP
cord-326960-9phlylce	219	17	vaccines	vaccine	NNS
cord-326960-9phlylce	219	18	will	will	MD
cord-326960-9phlylce	219	19	be	be	VB
cord-326960-9phlylce	219	20	standardizing	standardize	VBG
cord-326960-9phlylce	219	21	the	the	DT
cord-326960-9phlylce	219	22	vaccines	vaccine	NNS
cord-326960-9phlylce	219	23	for	for	IN
cord-326960-9phlylce	219	24	each	each	DT
cord-326960-9phlylce	219	25	of	of	IN
cord-326960-9phlylce	219	26	their	-PRON-	PRP$
cord-326960-9phlylce	219	27	components	component	NNS
cord-326960-9phlylce	219	28	(	(	-LRB-
cord-326960-9phlylce	219	29	e.g.	e.g.	RB
cord-326960-9phlylce	219	30	,	,	,
cord-326960-9phlylce	219	31	quantity	quantity	NN
cord-326960-9phlylce	219	32	of	of	IN
cord-326960-9phlylce	219	33	HA	HA	NNP
cord-326960-9phlylce	219	34	vs.	vs.	FW
cord-326960-9phlylce	219	35	NA	NA	NNP
cord-326960-9phlylce	219	36	vs.	vs.	FW
cord-326960-9phlylce	219	37	M1	M1	NNP
cord-326960-9phlylce	219	38	)	)	-RRB-
cord-326960-9phlylce	219	39	.	.	.
cord-326960-9phlylce	220	1	An	an	DT
cord-326960-9phlylce	220	2	advantage	advantage	NN
cord-326960-9phlylce	220	3	of	of	IN
cord-326960-9phlylce	220	4	using	use	VBG
cord-326960-9phlylce	220	5	recombinant	recombinant	JJ
cord-326960-9phlylce	220	6	technology	technology	NN
cord-326960-9phlylce	220	7	for	for	IN
cord-326960-9phlylce	220	8	vaccine	vaccine	NN
cord-326960-9phlylce	220	9	design	design	NN
cord-326960-9phlylce	220	10	is	be	VBZ
cord-326960-9phlylce	220	11	the	the	DT
cord-326960-9phlylce	220	12	opportunity	opportunity	NN
cord-326960-9phlylce	220	13	to	to	TO
cord-326960-9phlylce	220	14	modularly	modularly	RB
cord-326960-9phlylce	220	15	add	add	VB
cord-326960-9phlylce	220	16	or	or	CC
cord-326960-9phlylce	220	17	subtract	subtract	VB
cord-326960-9phlylce	220	18	antigens	antigen	NNS
cord-326960-9phlylce	220	19	to	to	IN
cord-326960-9phlylce	220	20	a	a	DT
cord-326960-9phlylce	220	21	formulation	formulation	NN
cord-326960-9phlylce	220	22	.	.	.
cord-326960-9phlylce	221	1	Inclusion	inclusion	NN
cord-326960-9phlylce	221	2	of	of	IN
cord-326960-9phlylce	221	3	recombinant	recombinant	JJ
cord-326960-9phlylce	221	4	NA	NA	NNP
cord-326960-9phlylce	221	5	in	in	IN
cord-326960-9phlylce	221	6	VLP	VLP	NNP
cord-326960-9phlylce	221	7	vaccines	vaccine	NNS
cord-326960-9phlylce	221	8	has	have	VBZ
cord-326960-9phlylce	221	9	been	be	VBN
cord-326960-9phlylce	221	10	shown	show	VBN
cord-326960-9phlylce	221	11	to	to	TO
cord-326960-9phlylce	221	12	induce	induce	VB
cord-326960-9phlylce	221	13	formation	formation	NN
cord-326960-9phlylce	221	14	of	of	IN
cord-326960-9phlylce	221	15	anti	anti	JJ
cord-326960-9phlylce	221	16	-	-	JJ
cord-326960-9phlylce	221	17	neuraminidase	neuraminidase	JJ
cord-326960-9phlylce	221	18	antibodies	antibody	NNS
cord-326960-9phlylce	221	19	[	[	-LRB-
cord-326960-9phlylce	221	20	87	87	CD
cord-326960-9phlylce	221	21	]	]	-RRB-
cord-326960-9phlylce	221	22	.	.	.
cord-326960-9phlylce	222	1	It	-PRON-	PRP
cord-326960-9phlylce	222	2	has	have	VBZ
cord-326960-9phlylce	222	3	been	be	VBN
cord-326960-9phlylce	222	4	noted	note	VBN
cord-326960-9phlylce	222	5	that	that	IN
cord-326960-9phlylce	222	6	different	different	JJ
cord-326960-9phlylce	222	7	vaccine	vaccine	NN
cord-326960-9phlylce	222	8	compositions	composition	NNS
cord-326960-9phlylce	222	9	(	(	-LRB-
cord-326960-9phlylce	222	10	e.g.	e.g.	RB
cord-326960-9phlylce	222	11	,	,	,
cord-326960-9phlylce	222	12	VLP	VLP	NNP
cord-326960-9phlylce	222	13	vs.	vs.	FW
cord-326960-9phlylce	222	14	subunit	subunit	NN
cord-326960-9phlylce	222	15	vs.	vs.	IN
cord-326960-9phlylce	222	16	whole	whole	JJ
cord-326960-9phlylce	222	17	virion	virion	NN
cord-326960-9phlylce	222	18	)	)	-RRB-
cord-326960-9phlylce	222	19	induce	induce	VB
cord-326960-9phlylce	222	20	different	different	JJ
cord-326960-9phlylce	222	21	immune	immune	JJ
cord-326960-9phlylce	222	22	profiles	profile	NNS
cord-326960-9phlylce	222	23	in	in	IN
cord-326960-9phlylce	222	24	BALB	BALB	NNP
cord-326960-9phlylce	222	25	/	/	SYM
cord-326960-9phlylce	222	26	c	c	NN
cord-326960-9phlylce	222	27	mice	mouse	NNS
cord-326960-9phlylce	222	28	[	[	-LRB-
cord-326960-9phlylce	222	29	88	88	CD
cord-326960-9phlylce	222	30	]	]	-RRB-
cord-326960-9phlylce	222	31	.	.	.
cord-326960-9phlylce	223	1	While	while	IN
cord-326960-9phlylce	223	2	the	the	DT
cord-326960-9phlylce	223	3	advantages	advantage	NNS
cord-326960-9phlylce	223	4	of	of	IN
cord-326960-9phlylce	223	5	these	these	DT
cord-326960-9phlylce	223	6	various	various	JJ
cord-326960-9phlylce	223	7	profiles	profile	NNS
cord-326960-9phlylce	223	8	are	be	VBP
cord-326960-9phlylce	223	9	not	not	RB
cord-326960-9phlylce	223	10	yet	yet	RB
cord-326960-9phlylce	223	11	clear	clear	JJ
cord-326960-9phlylce	223	12	,	,	,
cord-326960-9phlylce	223	13	the	the	DT
cord-326960-9phlylce	223	14	flexibility	flexibility	NN
cord-326960-9phlylce	223	15	of	of	IN
cord-326960-9phlylce	223	16	the	the	DT
cord-326960-9phlylce	223	17	BEVS	BEVS	NNP
cord-326960-9phlylce	223	18	platform	platform	NN
cord-326960-9phlylce	223	19	enables	enable	VBZ
cord-326960-9phlylce	223	20	catering	catering	NN
cord-326960-9phlylce	223	21	towards	towards	IN
cord-326960-9phlylce	223	22	different	different	JJ
cord-326960-9phlylce	223	23	outputs	output	NNS
cord-326960-9phlylce	223	24	.	.	.
cord-326960-9phlylce	224	1	Besides	besides	IN
cord-326960-9phlylce	224	2	inclusion	inclusion	NN
cord-326960-9phlylce	224	3	in	in	IN
cord-326960-9phlylce	224	4	VLPs	vlp	NNS
cord-326960-9phlylce	224	5	,	,	,
cord-326960-9phlylce	224	6	recombinant	recombinant	JJ
cord-326960-9phlylce	224	7	NA	NA	NNP
cord-326960-9phlylce	224	8	can	can	MD
cord-326960-9phlylce	224	9	be	be	VB
cord-326960-9phlylce	224	10	individually	individually	RB
cord-326960-9phlylce	224	11	produced	produce	VBN
cord-326960-9phlylce	224	12	via	via	IN
cord-326960-9phlylce	224	13	BEVS	BEVS	NNP
cord-326960-9phlylce	224	14	and	and	CC
cord-326960-9phlylce	224	15	may	may	MD
cord-326960-9phlylce	224	16	serve	serve	VB
cord-326960-9phlylce	224	17	as	as	IN
cord-326960-9phlylce	224	18	a	a	DT
cord-326960-9phlylce	224	19	potentially	potentially	RB
cord-326960-9phlylce	224	20	efficacy	efficacy	NN
cord-326960-9phlylce	224	21	-	-	HYPH
cord-326960-9phlylce	224	22	enhancing	enhance	VBG
cord-326960-9phlylce	224	23	additive	additive	NN
cord-326960-9phlylce	224	24	to	to	IN
cord-326960-9phlylce	224	25	influenza	influenza	NN
cord-326960-9phlylce	224	26	vaccines	vaccine	NNS
cord-326960-9phlylce	224	27	[	[	-LRB-
cord-326960-9phlylce	224	28	89	89	CD
cord-326960-9phlylce	224	29	]	]	-RRB-
cord-326960-9phlylce	224	30	.	.	.
cord-326960-9phlylce	225	1	NA	NA	NNP
cord-326960-9phlylce	225	2	immunity	immunity	NN
cord-326960-9phlylce	225	3	is	be	VBZ
cord-326960-9phlylce	225	4	infection	infection	NN
cord-326960-9phlylce	225	5	-	-	HYPH
cord-326960-9phlylce	225	6	permissive	permissive	JJ
cord-326960-9phlylce	225	7	but	but	CC
cord-326960-9phlylce	225	8	can	can	MD
cord-326960-9phlylce	225	9	reduce	reduce	VB
cord-326960-9phlylce	225	10	infection	infection	NN
cord-326960-9phlylce	225	11	severity	severity	NN
cord-326960-9phlylce	225	12	and	and	CC
cord-326960-9phlylce	225	13	duration	duration	NN
cord-326960-9phlylce	225	14	[	[	-LRB-
cord-326960-9phlylce	225	15	90	90	CD
cord-326960-9phlylce	225	16	]	]	-RRB-
cord-326960-9phlylce	225	17	.	.	.
cord-326960-9phlylce	226	1	The	the	DT
cord-326960-9phlylce	226	2	potential	potential	JJ
cord-326960-9phlylce	226	3	benefits	benefit	NNS
cord-326960-9phlylce	226	4	of	of	IN
cord-326960-9phlylce	226	5	including	include	VBG
cord-326960-9phlylce	226	6	recombinant	recombinant	JJ
cord-326960-9phlylce	226	7	NA	NA	NNP
cord-326960-9phlylce	226	8	in	in	IN
cord-326960-9phlylce	226	9	influenza	influenza	NN
cord-326960-9phlylce	226	10	vaccines	vaccine	NNS
cord-326960-9phlylce	226	11	has	have	VBZ
cord-326960-9phlylce	226	12	recently	recently	RB
cord-326960-9phlylce	226	13	been	be	VBN
cord-326960-9phlylce	226	14	reviewed	review	VBN
cord-326960-9phlylce	226	15	[	[	-LRB-
cord-326960-9phlylce	226	16	90	90	CD
cord-326960-9phlylce	226	17	]	]	-RRB-
cord-326960-9phlylce	226	18	.	.	.
cord-326960-9phlylce	227	1	Other	other	JJ
cord-326960-9phlylce	227	2	opportunities	opportunity	NNS
cord-326960-9phlylce	227	3	have	have	VBP
cord-326960-9phlylce	227	4	emerged	emerge	VBN
cord-326960-9phlylce	227	5	with	with	IN
cord-326960-9phlylce	227	6	BEVS	BEVS	NNP
cord-326960-9phlylce	227	7	as	as	IN
cord-326960-9phlylce	227	8	researchers	researcher	NNS
cord-326960-9phlylce	227	9	begin	begin	VBP
cord-326960-9phlylce	227	10	pursuit	pursuit	NN
cord-326960-9phlylce	227	11	of	of	IN
cord-326960-9phlylce	227	12	a	a	DT
cord-326960-9phlylce	227	13	so	so	RB
cord-326960-9phlylce	227	14	-	-	HYPH
cord-326960-9phlylce	227	15	called	call	VBN
cord-326960-9phlylce	227	16	universal	universal	JJ
cord-326960-9phlylce	227	17	influenza	influenza	NN
cord-326960-9phlylce	227	18	vaccine	vaccine	NN
cord-326960-9phlylce	227	19	.	.	.
cord-326960-9phlylce	228	1	Licensed	licensed	JJ
cord-326960-9phlylce	228	2	influenza	influenza	NN
cord-326960-9phlylce	228	3	vaccines	vaccine	NNS
cord-326960-9phlylce	228	4	offer	offer	VBP
cord-326960-9phlylce	228	5	limited	limited	JJ
cord-326960-9phlylce	228	6	cross	cross	NN
cord-326960-9phlylce	228	7	protection	protection	NN
cord-326960-9phlylce	228	8	to	to	IN
cord-326960-9phlylce	228	9	heterologous	heterologous	NNP
cord-326960-9phlylce	228	10	influenza	influenza	NN
cord-326960-9phlylce	228	11	viruses	virus	NNS
cord-326960-9phlylce	228	12	and	and	CC
cord-326960-9phlylce	228	13	,	,	,
cord-326960-9phlylce	228	14	thus	thus	RB
cord-326960-9phlylce	228	15	,	,	,
cord-326960-9phlylce	228	16	there	there	EX
cord-326960-9phlylce	228	17	is	be	VBZ
cord-326960-9phlylce	228	18	the	the	DT
cord-326960-9phlylce	228	19	need	need	NN
cord-326960-9phlylce	228	20	for	for	IN
cord-326960-9phlylce	228	21	annual	annual	JJ
cord-326960-9phlylce	228	22	update	update	NN
cord-326960-9phlylce	228	23	of	of	IN
cord-326960-9phlylce	228	24	seasonal	seasonal	JJ
cord-326960-9phlylce	228	25	influenza	influenza	NN
cord-326960-9phlylce	228	26	vaccines	vaccine	NNS
cord-326960-9phlylce	228	27	and	and	CC
cord-326960-9phlylce	228	28	concern	concern	NN
cord-326960-9phlylce	228	29	over	over	IN
cord-326960-9phlylce	228	30	pandemic	pandemic	NN
cord-326960-9phlylce	228	31	preparedness	preparedness	NN
cord-326960-9phlylce	228	32	.	.	.
cord-326960-9phlylce	229	1	A	a	DT
cord-326960-9phlylce	229	2	successful	successful	JJ
cord-326960-9phlylce	229	3	universal	universal	JJ
cord-326960-9phlylce	229	4	influenza	influenza	NN
cord-326960-9phlylce	229	5	vaccine	vaccine	NN
cord-326960-9phlylce	229	6	would	would	MD
cord-326960-9phlylce	229	7	offer	offer	VB
cord-326960-9phlylce	229	8	long	long	RB
cord-326960-9phlylce	229	9	-	-	HYPH
cord-326960-9phlylce	229	10	lasting	last	VBG
cord-326960-9phlylce	229	11	and	and	CC
cord-326960-9phlylce	229	12	broad	broad	JJ
cord-326960-9phlylce	229	13	protection	protection	NN
cord-326960-9phlylce	229	14	against	against	IN
cord-326960-9phlylce	229	15	a	a	DT
cord-326960-9phlylce	229	16	range	range	NN
cord-326960-9phlylce	229	17	of	of	IN
cord-326960-9phlylce	229	18	different	different	JJ
cord-326960-9phlylce	229	19	influenza	influenza	NN
cord-326960-9phlylce	229	20	virus	virus	NN
cord-326960-9phlylce	229	21	strains	strain	NNS
cord-326960-9phlylce	229	22	.	.	.
cord-326960-9phlylce	230	1	Approaches	approach	NNS
cord-326960-9phlylce	230	2	to	to	IN
cord-326960-9phlylce	230	3	universal	universal	JJ
cord-326960-9phlylce	230	4	influenza	influenza	JJ
cord-326960-9phlylce	230	5	vaccine	vaccine	NN
cord-326960-9phlylce	230	6	design	design	NN
cord-326960-9phlylce	230	7	include	include	VBP
cord-326960-9phlylce	230	8	HA	HA	NNP
cord-326960-9phlylce	230	9	stalk	stalk	VB
cord-326960-9phlylce	230	10	-	-	HYPH
cord-326960-9phlylce	230	11	based	base	VBN
cord-326960-9phlylce	230	12	constructs	construct	NNS
cord-326960-9phlylce	230	13	and	and	CC
cord-326960-9phlylce	230	14	chimeric	chimeric	JJ
cord-326960-9phlylce	230	15	HA	HA	NNP
cord-326960-9phlylce	230	16	-	-	HYPH
cord-326960-9phlylce	230	17	based	base	VBN
cord-326960-9phlylce	230	18	vaccines	vaccine	NNS
cord-326960-9phlylce	230	19	that	that	WDT
cord-326960-9phlylce	230	20	are	be	VBP
cord-326960-9phlylce	230	21	composed	compose	VBN
cord-326960-9phlylce	230	22	of	of	IN
cord-326960-9phlylce	230	23	conserved	conserve	VBN
cord-326960-9phlylce	230	24	stalk	stalk	NN
cord-326960-9phlylce	230	25	domains	domain	NNS
cord-326960-9phlylce	230	26	fused	fuse	VBN
cord-326960-9phlylce	230	27	to	to	IN
cord-326960-9phlylce	230	28	"	"	``
cord-326960-9phlylce	230	29	exotic	exotic	JJ
cord-326960-9phlylce	230	30	"	"	''
cord-326960-9phlylce	230	31	heads	head	NNS
cord-326960-9phlylce	230	32	,	,	,
cord-326960-9phlylce	230	33	usually	usually	RB
cord-326960-9phlylce	230	34	of	of	IN
cord-326960-9phlylce	230	35	avian	avian	JJ
cord-326960-9phlylce	230	36	origin	origin	NN
cord-326960-9phlylce	230	37	(	(	-LRB-
cord-326960-9phlylce	230	38	these	these	DT
cord-326960-9phlylce	230	39	approaches	approach	NNS
cord-326960-9phlylce	230	40	are	be	VBP
cord-326960-9phlylce	230	41	reviewed	review	VBN
cord-326960-9phlylce	230	42	elsewhere	elsewhere	RB
cord-326960-9phlylce	230	43	[	[	-LRB-
cord-326960-9phlylce	230	44	91	91	CD
cord-326960-9phlylce	230	45	]	]	-RRB-
cord-326960-9phlylce	230	46	)	)	-RRB-
cord-326960-9phlylce	230	47	.	.	.
cord-326960-9phlylce	231	1	The	the	DT
cord-326960-9phlylce	231	2	BEVS	BEVS	NNP
cord-326960-9phlylce	231	3	platform	platform	NN
cord-326960-9phlylce	231	4	,	,	,
cord-326960-9phlylce	231	5	being	be	VBG
cord-326960-9phlylce	231	6	based	base	VBN
cord-326960-9phlylce	231	7	on	on	IN
cord-326960-9phlylce	231	8	recombinant	recombinant	JJ
cord-326960-9phlylce	231	9	technology	technology	NN
cord-326960-9phlylce	231	10	,	,	,
cord-326960-9phlylce	231	11	offers	offer	VBZ
cord-326960-9phlylce	231	12	the	the	DT
cord-326960-9phlylce	231	13	flexibility	flexibility	NN
cord-326960-9phlylce	231	14	and	and	CC
cord-326960-9phlylce	231	15	genetic	genetic	JJ
cord-326960-9phlylce	231	16	control	control	NN
cord-326960-9phlylce	231	17	required	require	VBN
cord-326960-9phlylce	231	18	for	for	IN
cord-326960-9phlylce	231	19	the	the	DT
cord-326960-9phlylce	231	20	design	design	NN
cord-326960-9phlylce	231	21	and	and	CC
cord-326960-9phlylce	231	22	manufacture	manufacture	NN
cord-326960-9phlylce	231	23	of	of	IN
cord-326960-9phlylce	231	24	these	these	DT
cord-326960-9phlylce	231	25	universal	universal	JJ
cord-326960-9phlylce	231	26	vaccine	vaccine	NN
cord-326960-9phlylce	231	27	candidates	candidate	NNS
cord-326960-9phlylce	231	28	.	.	.
cord-326960-9phlylce	231	29	 	 	_SP
cord-326960-9phlylce	232	1	In	in	IN
cord-326960-9phlylce	232	2	this	this	DT
cord-326960-9phlylce	232	3	review	review	NN
cord-326960-9phlylce	232	4	we	-PRON-	PRP
cord-326960-9phlylce	232	5	have	have	VBP
cord-326960-9phlylce	232	6	taken	take	VBN
cord-326960-9phlylce	232	7	a	a	DT
cord-326960-9phlylce	232	8	close	close	JJ
cord-326960-9phlylce	232	9	look	look	NN
cord-326960-9phlylce	232	10	at	at	IN
cord-326960-9phlylce	232	11	the	the	DT
cord-326960-9phlylce	232	12	BEVS	BEVS	NNP
cord-326960-9phlylce	232	13	platform	platform	NN
cord-326960-9phlylce	232	14	,	,	,
cord-326960-9phlylce	232	15	describing	describe	VBG
cord-326960-9phlylce	232	16	how	how	WRB
cord-326960-9phlylce	232	17	the	the	DT
cord-326960-9phlylce	232	18	platform	platform	NN
cord-326960-9phlylce	232	19	works	work	VBZ
cord-326960-9phlylce	232	20	,	,	,
cord-326960-9phlylce	232	21	outlining	outline	VBG
cord-326960-9phlylce	232	22	the	the	DT
cord-326960-9phlylce	232	23	features	feature	NNS
cord-326960-9phlylce	232	24	and	and	CC
cord-326960-9phlylce	232	25	limitations	limitation	NNS
cord-326960-9phlylce	232	26	of	of	IN
cord-326960-9phlylce	232	27	the	the	DT
cord-326960-9phlylce	232	28	technology	technology	NN
cord-326960-9phlylce	232	29	and	and	CC
cord-326960-9phlylce	232	30	highlighting	highlight	VBG
cord-326960-9phlylce	232	31	the	the	DT
cord-326960-9phlylce	232	32	growth	growth	NN
cord-326960-9phlylce	232	33	opportunities	opportunity	NNS
cord-326960-9phlylce	232	34	that	that	WDT
cord-326960-9phlylce	232	35	emerged	emerge	VBD
cord-326960-9phlylce	232	36	from	from	IN
cord-326960-9phlylce	232	37	the	the	DT
cord-326960-9phlylce	232	38	two	two	CD
cord-326960-9phlylce	232	39	most	most	RBS
cord-326960-9phlylce	232	40	recent	recent	JJ
cord-326960-9phlylce	232	41	BEVS	bevs	NN
cord-326960-9phlylce	232	42	-	-	HYPH
cord-326960-9phlylce	232	43	derived	derive	VBN
cord-326960-9phlylce	232	44	product	product	NN
cord-326960-9phlylce	232	45	approvals	approval	NNS
cord-326960-9phlylce	232	46	.	.	.
cord-326960-9phlylce	233	1	We	-PRON-	PRP
cord-326960-9phlylce	233	2	expect	expect	VBP
cord-326960-9phlylce	233	3	this	this	DT
cord-326960-9phlylce	233	4	growth	growth	NN
cord-326960-9phlylce	233	5	to	to	TO
cord-326960-9phlylce	233	6	continue	continue	VB
cord-326960-9phlylce	233	7	and	and	CC
cord-326960-9phlylce	233	8	expand	expand	VB
cord-326960-9phlylce	233	9	as	as	IN
cord-326960-9phlylce	233	10	future	future	JJ
cord-326960-9phlylce	233	11	BEVSderived	bevsderive	VBN
cord-326960-9phlylce	233	12	products	product	NNS
cord-326960-9phlylce	233	13	attain	attain	VBP
cord-326960-9phlylce	233	14	regulatory	regulatory	JJ
cord-326960-9phlylce	233	15	approval	approval	NN
cord-326960-9phlylce	233	16	.	.	.
cord-326960-9phlylce	234	1	The	the	DT
cord-326960-9phlylce	234	2	approvals	approval	NNS
cord-326960-9phlylce	234	3	of	of	IN
cord-326960-9phlylce	234	4	BEVS	bevs	NN
cord-326960-9phlylce	234	5	-	-	HYPH
cord-326960-9phlylce	234	6	derived	derive	VBN
cord-326960-9phlylce	234	7	Cervarix	Cervarix	NNP
cord-326960-9phlylce	234	8	®	®	POS
cord-326960-9phlylce	234	9	and	and	CC
cord-326960-9phlylce	234	10	Flublok	Flublok	NNP
cord-326960-9phlylce	235	1	®	®	LS
cord-326960-9phlylce	235	2	vaccines	vaccine	NNS
cord-326960-9phlylce	235	3	have	have	VBP
cord-326960-9phlylce	235	4	broadened	broaden	VBN
cord-326960-9phlylce	235	5	the	the	DT
cord-326960-9phlylce	235	6	acceptance	acceptance	NN
cord-326960-9phlylce	235	7	of	of	IN
cord-326960-9phlylce	235	8	the	the	DT
cord-326960-9phlylce	235	9	platform	platform	NN
cord-326960-9phlylce	235	10	beyond	beyond	IN
cord-326960-9phlylce	235	11	its	-PRON-	PRP$
cord-326960-9phlylce	235	12	initial	initial	JJ
cord-326960-9phlylce	235	13	veterinary	veterinary	JJ
cord-326960-9phlylce	235	14	borders	border	NNS
cord-326960-9phlylce	235	15	to	to	TO
cord-326960-9phlylce	235	16	use	use	VB
cord-326960-9phlylce	235	17	in	in	IN
cord-326960-9phlylce	235	18	healthy	healthy	JJ
cord-326960-9phlylce	235	19	adolescents	adolescent	NNS
cord-326960-9phlylce	235	20	and	and	CC
cord-326960-9phlylce	235	21	adults	adult	NNS
cord-326960-9phlylce	235	22	.	.	.
cord-326960-9phlylce	236	1	Human	human	JJ
cord-326960-9phlylce	236	2	therapeutics	therapeutic	NNS
cord-326960-9phlylce	236	3	is	be	VBZ
cord-326960-9phlylce	236	4	another	another	DT
cord-326960-9phlylce	236	5	area	area	NN
cord-326960-9phlylce	236	6	of	of	IN
cord-326960-9phlylce	236	7	use	use	NN
cord-326960-9phlylce	236	8	and	and	CC
cord-326960-9phlylce	236	9	gene	gene	NN
cord-326960-9phlylce	236	10	therapy	therapy	NN
cord-326960-9phlylce	236	11	in	in	IN
cord-326960-9phlylce	236	12	particular	particular	JJ
cord-326960-9phlylce	236	13	is	be	VBZ
cord-326960-9phlylce	236	14	a	a	DT
cord-326960-9phlylce	236	15	growing	grow	VBG
cord-326960-9phlylce	236	16	area	area	NN
cord-326960-9phlylce	236	17	of	of	IN
cord-326960-9phlylce	236	18	interest	interest	NN
cord-326960-9phlylce	236	19	;	;	:
cord-326960-9phlylce	236	20	the	the	DT
cord-326960-9phlylce	236	21	approval	approval	NN
cord-326960-9phlylce	236	22	of	of	IN
cord-326960-9phlylce	236	23	Glybera	Glybera	NNP
cord-326960-9phlylce	236	24	drew	draw	VBD
cord-326960-9phlylce	236	25	major	major	JJ
cord-326960-9phlylce	236	26	attention	attention	NN
cord-326960-9phlylce	236	27	to	to	IN
cord-326960-9phlylce	236	28	BEVS	bevs	NN
cord-326960-9phlylce	236	29	-	-	HYPH
cord-326960-9phlylce	236	30	derived	derive	VBN
cord-326960-9phlylce	236	31	rAAVs	raav	NNS
cord-326960-9phlylce	236	32	.	.	.
cord-326960-9phlylce	237	1	Baculoviruses	baculoviruse	NNS
cord-326960-9phlylce	237	2	themselves	-PRON-	PRP
cord-326960-9phlylce	237	3	can	can	MD
cord-326960-9phlylce	237	4	also	also	RB
cord-326960-9phlylce	237	5	be	be	VB
cord-326960-9phlylce	237	6	used	use	VBN
cord-326960-9phlylce	237	7	as	as	IN
cord-326960-9phlylce	238	1	gene	gene	NN
cord-326960-9phlylce	238	2	delivery	delivery	NN
cord-326960-9phlylce	238	3	vectors	vector	NNS
cord-326960-9phlylce	238	4	,	,	,
cord-326960-9phlylce	238	5	and	and	CC
cord-326960-9phlylce	238	6	other	other	JJ
cord-326960-9phlylce	238	7	recombinant	recombinant	JJ
cord-326960-9phlylce	238	8	protein	protein	NN
cord-326960-9phlylce	238	9	complexes	complex	NNS
cord-326960-9phlylce	238	10	produced	produce	VBD
cord-326960-9phlylce	238	11	using	use	VBG
cord-326960-9phlylce	238	12	BEVS	BEVS	NNP
cord-326960-9phlylce	238	13	are	be	VBP
cord-326960-9phlylce	238	14	being	be	VBG
cord-326960-9phlylce	238	15	explored	explore	VBN
cord-326960-9phlylce	238	16	for	for	IN
cord-326960-9phlylce	238	17	the	the	DT
cord-326960-9phlylce	238	18	delivery	delivery	NN
cord-326960-9phlylce	238	19	of	of	IN
cord-326960-9phlylce	238	20	various	various	JJ
cord-326960-9phlylce	238	21	peptides	peptide	NNS
cord-326960-9phlylce	238	22	and	and	CC
cord-326960-9phlylce	238	23	antigens	antigen	NNS
cord-326960-9phlylce	238	24	,	,	,
cord-326960-9phlylce	238	25	such	such	JJ
cord-326960-9phlylce	238	26	as	as	IN
cord-326960-9phlylce	238	27	in	in	IN
cord-326960-9phlylce	238	28	the	the	DT
cord-326960-9phlylce	238	29	form	form	NN
cord-326960-9phlylce	238	30	of	of	IN
cord-326960-9phlylce	238	31	the	the	DT
cord-326960-9phlylce	238	32	newly	newly	RB
cord-326960-9phlylce	238	33	characterized	characterize	VBN
cord-326960-9phlylce	238	34	vault	vault	NN
cord-326960-9phlylce	238	35	particles	particle	NNS
cord-326960-9phlylce	238	36	[	[	-LRB-
cord-326960-9phlylce	238	37	92	92	CD
cord-326960-9phlylce	238	38	]	]	-RRB-
cord-326960-9phlylce	238	39	.	.	.
cord-326960-9phlylce	239	1	The	the	DT
cord-326960-9phlylce	239	2	speed	speed	NN
cord-326960-9phlylce	239	3	at	at	IN
cord-326960-9phlylce	239	4	which	which	WDT
cord-326960-9phlylce	239	5	recombinant	recombinant	JJ
cord-326960-9phlylce	239	6	proteins	protein	NNS
cord-326960-9phlylce	239	7	can	can	MD
cord-326960-9phlylce	239	8	be	be	VB
cord-326960-9phlylce	239	9	produced	produce	VBN
cord-326960-9phlylce	239	10	using	use	VBG
cord-326960-9phlylce	239	11	BEVS	BEVS	NNP
cord-326960-9phlylce	239	12	makes	make	VBZ
cord-326960-9phlylce	239	13	it	-PRON-	PRP
cord-326960-9phlylce	239	14	a	a	DT
cord-326960-9phlylce	239	15	particularly	particularly	RB
cord-326960-9phlylce	239	16	attractive	attractive	JJ
cord-326960-9phlylce	239	17	platform	platform	NN
cord-326960-9phlylce	239	18	to	to	TO
cord-326960-9phlylce	239	19	design	design	VB
cord-326960-9phlylce	239	20	safe	safe	JJ
cord-326960-9phlylce	239	21	and	and	CC
cord-326960-9phlylce	239	22	effective	effective	JJ
cord-326960-9phlylce	239	23	vaccines	vaccine	NNS
cord-326960-9phlylce	239	24	to	to	TO
cord-326960-9phlylce	239	25	be	be	VB
cord-326960-9phlylce	239	26	available	available	JJ
cord-326960-9phlylce	239	27	to	to	TO
cord-326960-9phlylce	239	28	timely	timely	RB
cord-326960-9phlylce	239	29	combat	combat	VB
cord-326960-9phlylce	239	30	new	new	JJ
cord-326960-9phlylce	239	31	infectious	infectious	JJ
cord-326960-9phlylce	239	32	pathogens	pathogen	NNS
cord-326960-9phlylce	239	33	as	as	IN
cord-326960-9phlylce	239	34	they	-PRON-	PRP
cord-326960-9phlylce	239	35	arise	arise	VBP
cord-326960-9phlylce	239	36	.	.	.
cord-326960-9phlylce	240	1	Success	success	NN
cord-326960-9phlylce	240	2	with	with	IN
cord-326960-9phlylce	240	3	this	this	DT
cord-326960-9phlylce	240	4	approach	approach	NN
cord-326960-9phlylce	240	5	has	have	VBZ
cord-326960-9phlylce	240	6	been	be	VBN
cord-326960-9phlylce	240	7	demonstrated	demonstrate	VBN
cord-326960-9phlylce	240	8	for	for	IN
cord-326960-9phlylce	240	9	influenza	influenza	NN
cord-326960-9phlylce	240	10	and	and	CC
cord-326960-9phlylce	240	11	can	can	MD
cord-326960-9phlylce	240	12	be	be	VB
cord-326960-9phlylce	240	13	applied	apply	VBN
cord-326960-9phlylce	240	14	to	to	IN
cord-326960-9phlylce	240	15	broader	broad	JJR
cord-326960-9phlylce	240	16	areas	area	NNS
cord-326960-9phlylce	240	17	.	.	.
cord-326960-9phlylce	241	1	For	for	IN
cord-326960-9phlylce	241	2	example	example	NN
cord-326960-9phlylce	241	3	,	,	,
cord-326960-9phlylce	241	4	coronaviruses	coronaviruse	NNS
cord-326960-9phlylce	241	5	have	have	VBP
cord-326960-9phlylce	241	6	been	be	VBN
cord-326960-9phlylce	241	7	plaguing	plague	VBG
cord-326960-9phlylce	241	8	both	both	DT
cord-326960-9phlylce	241	9	people	people	NNS
cord-326960-9phlylce	241	10	and	and	CC
cord-326960-9phlylce	241	11	animals	animal	NNS
cord-326960-9phlylce	241	12	especially	especially	RB
cord-326960-9phlylce	241	13	in	in	IN
cord-326960-9phlylce	241	14	the	the	DT
cord-326960-9phlylce	241	15	last	last	JJ
cord-326960-9phlylce	241	16	decade	decade	NN
cord-326960-9phlylce	241	17	with	with	IN
cord-326960-9phlylce	241	18	lethal	lethal	JJ
cord-326960-9phlylce	241	19	outbreaks	outbreak	NNS
cord-326960-9phlylce	241	20	of	of	IN
cord-326960-9phlylce	241	21	severe	severe	JJ
cord-326960-9phlylce	241	22	acute	acute	JJ
cord-326960-9phlylce	241	23	respiratory	respiratory	JJ
cord-326960-9phlylce	241	24	syndrome	syndrome	NN
cord-326960-9phlylce	241	25	(	(	-LRB-
cord-326960-9phlylce	241	26	SARS	SARS	NNP
cord-326960-9phlylce	241	27	)	)	-RRB-
cord-326960-9phlylce	241	28	in	in	IN
cord-326960-9phlylce	241	29	2003	2003	CD
cord-326960-9phlylce	241	30	,	,	,
cord-326960-9phlylce	241	31	Middle	Middle	NNP
cord-326960-9phlylce	241	32	East	East	NNP
cord-326960-9phlylce	241	33	respiratory	respiratory	JJ
cord-326960-9phlylce	241	34	syndrome	syndrome	NN
cord-326960-9phlylce	241	35	(	(	-LRB-
cord-326960-9phlylce	241	36	MERS	MERS	NNP
cord-326960-9phlylce	241	37	)	)	-RRB-
cord-326960-9phlylce	241	38	in	in	IN
cord-326960-9phlylce	241	39	late	late	JJ
cord-326960-9phlylce	241	40	2012	2012	CD
cord-326960-9phlylce	241	41	,	,	,
cord-326960-9phlylce	241	42	and	and	CC
cord-326960-9phlylce	241	43	porcine	porcine	JJ
cord-326960-9phlylce	241	44	epidemic	epidemic	NN
cord-326960-9phlylce	241	45	diarrhea	diarrhea	NN
cord-326960-9phlylce	241	46	virus	virus	NN
cord-326960-9phlylce	241	47	(	(	-LRB-
cord-326960-9phlylce	241	48	PEDV	PEDV	NNP
cord-326960-9phlylce	241	49	)	)	-RRB-
cord-326960-9phlylce	241	50	in	in	IN
cord-326960-9phlylce	241	51	2013	2013	CD
cord-326960-9phlylce	241	52	[	[	-LRB-
cord-326960-9phlylce	241	53	93	93	CD
cord-326960-9phlylce	241	54	]	]	-RRB-
cord-326960-9phlylce	241	55	[	[	-LRB-
cord-326960-9phlylce	241	56	94	94	CD
cord-326960-9phlylce	241	57	]	]	-RRB-
cord-326960-9phlylce	241	58	[	[	-LRB-
cord-326960-9phlylce	241	59	95	95	CD
cord-326960-9phlylce	241	60	]	]	-RRB-
cord-326960-9phlylce	241	61	.	.	.
cord-326960-9phlylce	242	1	All	all	DT
cord-326960-9phlylce	242	2	coronaviruses	coronaviruse	NNS
cord-326960-9phlylce	242	3	share	share	VBP
cord-326960-9phlylce	242	4	a	a	DT
cord-326960-9phlylce	242	5	similar	similar	JJ
cord-326960-9phlylce	242	6	structure	structure	NN
cord-326960-9phlylce	242	7	that	that	WDT
cord-326960-9phlylce	242	8	includes	include	VBZ
cord-326960-9phlylce	242	9	the	the	DT
cord-326960-9phlylce	242	10	presence	presence	NN
cord-326960-9phlylce	242	11	of	of	IN
cord-326960-9phlylce	242	12	the	the	DT
cord-326960-9phlylce	242	13	spike	spike	NN
cord-326960-9phlylce	242	14	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	242	15	on	on	IN
cord-326960-9phlylce	242	16	the	the	DT
cord-326960-9phlylce	242	17	viral	viral	JJ
cord-326960-9phlylce	242	18	envelope	envelope	NN
cord-326960-9phlylce	242	19	that	that	WDT
cord-326960-9phlylce	242	20	is	be	VBZ
cord-326960-9phlylce	242	21	the	the	DT
cord-326960-9phlylce	242	22	dominant	dominant	JJ
cord-326960-9phlylce	242	23	immunogen	immunogen	NN
cord-326960-9phlylce	242	24	[	[	-LRB-
cord-326960-9phlylce	242	25	96	96	CD
cord-326960-9phlylce	242	26	]	]	-RRB-
cord-326960-9phlylce	242	27	[	[	-LRB-
cord-326960-9phlylce	242	28	97	97	CD
cord-326960-9phlylce	242	29	]	]	-RRB-
cord-326960-9phlylce	242	30	[	[	-LRB-
cord-326960-9phlylce	242	31	98	98	CD
cord-326960-9phlylce	242	32	]	]	-RRB-
cord-326960-9phlylce	242	33	.	.	.
cord-326960-9phlylce	243	1	Multiple	multiple	JJ
cord-326960-9phlylce	243	2	coronavirus	coronavirus	NN
cord-326960-9phlylce	244	1	BEVS	bevs	NN
cord-326960-9phlylce	244	2	-	-	HYPH
cord-326960-9phlylce	244	3	derived	derive	VBN
cord-326960-9phlylce	244	4	vaccine	vaccine	NN
cord-326960-9phlylce	244	5	candidates	candidate	NNS
cord-326960-9phlylce	244	6	have	have	VBP
cord-326960-9phlylce	244	7	been	be	VBN
cord-326960-9phlylce	244	8	developed	develop	VBN
cord-326960-9phlylce	244	9	that	that	WDT
cord-326960-9phlylce	244	10	include	include	VBP
cord-326960-9phlylce	244	11	recombinant	recombinant	JJ
cord-326960-9phlylce	244	12	spike	spike	NN
cord-326960-9phlylce	244	13	protein	protein	NN
cord-326960-9phlylce	244	14	either	either	RB
cord-326960-9phlylce	244	15	alone	alone	RB
cord-326960-9phlylce	244	16	as	as	IN
cord-326960-9phlylce	244	17	a	a	DT
cord-326960-9phlylce	244	18	subunit	subunit	NN
cord-326960-9phlylce	244	19	vaccine	vaccine	NN
cord-326960-9phlylce	244	20	or	or	CC
cord-326960-9phlylce	244	21	together	together	RB
cord-326960-9phlylce	244	22	with	with	IN
cord-326960-9phlylce	244	23	recombinant	recombinant	JJ
cord-326960-9phlylce	244	24	envelope	envelope	NN
cord-326960-9phlylce	244	25	and	and	CC
cord-326960-9phlylce	244	26	membrane	membrane	NN
cord-326960-9phlylce	244	27	proteins	protein	NNS
cord-326960-9phlylce	244	28	as	as	IN
cord-326960-9phlylce	244	29	VLPs	vlp	NNS
cord-326960-9phlylce	244	30	and	and	CC
cord-326960-9phlylce	244	31	have	have	VBP
cord-326960-9phlylce	244	32	demonstrated	demonstrate	VBN
cord-326960-9phlylce	244	33	efficacy	efficacy	NN
cord-326960-9phlylce	244	34	in	in	IN
cord-326960-9phlylce	244	35	animal	animal	NN
cord-326960-9phlylce	244	36	models	model	NNS
cord-326960-9phlylce	244	37	[	[	-LRB-
cord-326960-9phlylce	244	38	29	29	CD
cord-326960-9phlylce	244	39	,	,	,
cord-326960-9phlylce	244	40	[	[	-LRB-
cord-326960-9phlylce	244	41	99	99	CD
cord-326960-9phlylce	244	42	]	]	-RRB-
cord-326960-9phlylce	244	43	[	[	-LRB-
cord-326960-9phlylce	244	44	100	100	CD
cord-326960-9phlylce	244	45	]	]	-RRB-
cord-326960-9phlylce	244	46	[	[	-LRB-
cord-326960-9phlylce	244	47	101	101	CD
cord-326960-9phlylce	244	48	]	]	-RRB-
cord-326960-9phlylce	244	49	[	[	-LRB-
cord-326960-9phlylce	244	50	102	102	CD
cord-326960-9phlylce	244	51	]	]	-RRB-
cord-326960-9phlylce	244	52	[	[	-LRB-
cord-326960-9phlylce	244	53	103	103	CD
cord-326960-9phlylce	244	54	]	]	-RRB-
cord-326960-9phlylce	244	55	[	[	-LRB-
cord-326960-9phlylce	244	56	104	104	CD
cord-326960-9phlylce	244	57	]	]	-RRB-
cord-326960-9phlylce	244	58	[	[	-LRB-
cord-326960-9phlylce	244	59	105	105	CD
cord-326960-9phlylce	244	60	]	]	-RRB-
cord-326960-9phlylce	244	61	[	[	-LRB-
cord-326960-9phlylce	244	62	106	106	CD
cord-326960-9phlylce	244	63	]	]	-RRB-
cord-326960-9phlylce	244	64	[	[	-LRB-
cord-326960-9phlylce	244	65	107	107	CD
cord-326960-9phlylce	244	66	]	]	-RRB-
cord-326960-9phlylce	244	67	.	.	.
cord-326960-9phlylce	245	1	The	the	DT
cord-326960-9phlylce	245	2	spike	spike	NN
cord-326960-9phlylce	245	3	protein	protein	NN
cord-326960-9phlylce	245	4	has	have	VBZ
cord-326960-9phlylce	245	5	been	be	VBN
cord-326960-9phlylce	245	6	shown	show	VBN
cord-326960-9phlylce	245	7	to	to	TO
cord-326960-9phlylce	245	8	be	be	VB
cord-326960-9phlylce	245	9	immunogenic	immunogenic	JJ
cord-326960-9phlylce	245	10	both	both	CC
cord-326960-9phlylce	245	11	as	as	IN
cord-326960-9phlylce	245	12	full	full	JJ
cord-326960-9phlylce	245	13	length	length	NN
cord-326960-9phlylce	245	14	protein	protein	NN
cord-326960-9phlylce	245	15	and	and	CC
cord-326960-9phlylce	245	16	as	as	IN
cord-326960-9phlylce	245	17	a	a	DT
cord-326960-9phlylce	245	18	truncated	truncated	JJ
cord-326960-9phlylce	245	19	protein	protein	NN
cord-326960-9phlylce	245	20	containing	contain	VBG
cord-326960-9phlylce	245	21	only	only	RB
cord-326960-9phlylce	245	22	the	the	DT
cord-326960-9phlylce	245	23	extracellular	extracellular	JJ
cord-326960-9phlylce	245	24	domain	domain	NN
cord-326960-9phlylce	245	25	[	[	-LRB-
cord-326960-9phlylce	245	26	29	29	CD
cord-326960-9phlylce	245	27	,	,	,
cord-326960-9phlylce	245	28	100	100	CD
cord-326960-9phlylce	245	29	]	]	-RRB-
cord-326960-9phlylce	245	30	,	,	,
cord-326960-9phlylce	245	31	and	and	CC
cord-326960-9phlylce	245	32	multiple	multiple	JJ
cord-326960-9phlylce	245	33	routes	route	NNS
cord-326960-9phlylce	245	34	of	of	IN
cord-326960-9phlylce	245	35	vaccine	vaccine	NN
cord-326960-9phlylce	245	36	administration	administration	NN
cord-326960-9phlylce	245	37	have	have	VBP
cord-326960-9phlylce	245	38	been	be	VBN
cord-326960-9phlylce	245	39	examined	examine	VBN
cord-326960-9phlylce	245	40	[	[	-LRB-
cord-326960-9phlylce	245	41	104	104	CD
cord-326960-9phlylce	245	42	]	]	-RRB-
cord-326960-9phlylce	245	43	.	.	.
cord-326960-9phlylce	246	1	Two	two	CD
cord-326960-9phlylce	246	2	recently	recently	RB
cord-326960-9phlylce	246	3	emerged	emerge	VBD
cord-326960-9phlylce	246	4	threats	threat	NNS
cord-326960-9phlylce	246	5	are	be	VBP
cord-326960-9phlylce	246	6	chikungunya	chikungunya	NN
cord-326960-9phlylce	246	7	virus	virus	NN
cord-326960-9phlylce	246	8	and	and	CC
cord-326960-9phlylce	246	9	Ebola	Ebola	NNP
cord-326960-9phlylce	246	10	virus	virus	NN
cord-326960-9phlylce	246	11	,	,	,
cord-326960-9phlylce	246	12	both	both	DT
cord-326960-9phlylce	246	13	of	of	IN
cord-326960-9phlylce	246	14	which	which	WDT
cord-326960-9phlylce	246	15	can	can	MD
cord-326960-9phlylce	246	16	be	be	VB
cord-326960-9phlylce	246	17	addressed	address	VBN
cord-326960-9phlylce	246	18	with	with	IN
cord-326960-9phlylce	246	19	BEVS	bevs	NN
cord-326960-9phlylce	246	20	-	-	HYPH
cord-326960-9phlylce	246	21	derived	derive	VBN
cord-326960-9phlylce	246	22	vaccines	vaccine	NNS
cord-326960-9phlylce	246	23	.	.	.
cord-326960-9phlylce	247	1	Chikungunya	chikungunya	NN
cord-326960-9phlylce	247	2	virus	virus	NN
cord-326960-9phlylce	247	3	causes	cause	VBZ
cord-326960-9phlylce	247	4	a	a	DT
cord-326960-9phlylce	247	5	serious	serious	JJ
cord-326960-9phlylce	247	6	disease	disease	NN
cord-326960-9phlylce	247	7	that	that	WDT
cord-326960-9phlylce	247	8	involves	involve	VBZ
cord-326960-9phlylce	247	9	severe	severe	JJ
cord-326960-9phlylce	247	10	joint	joint	JJ
cord-326960-9phlylce	247	11	pain	pain	NN
cord-326960-9phlylce	247	12	and	and	CC
cord-326960-9phlylce	247	13	can	can	MD
cord-326960-9phlylce	247	14	be	be	VB
cord-326960-9phlylce	247	15	fatal	fatal	JJ
cord-326960-9phlylce	247	16	;	;	:
cord-326960-9phlylce	247	17	a	a	DT
cord-326960-9phlylce	247	18	recent	recent	JJ
cord-326960-9phlylce	247	19	outbreak	outbreak	NN
cord-326960-9phlylce	247	20	appeared	appear	VBD
cord-326960-9phlylce	247	21	in	in	IN
cord-326960-9phlylce	247	22	Saint	Saint	NNP
cord-326960-9phlylce	247	23	Martin	Martin	NNP
cord-326960-9phlylce	247	24	in	in	IN
cord-326960-9phlylce	247	25	December	December	NNP
cord-326960-9phlylce	247	26	2013	2013	CD
cord-326960-9phlylce	247	27	and	and	CC
cord-326960-9phlylce	247	28	has	have	VBZ
cord-326960-9phlylce	247	29	since	since	RB
cord-326960-9phlylce	247	30	made	make	VBN
cord-326960-9phlylce	247	31	its	-PRON-	PRP$
cord-326960-9phlylce	247	32	way	way	NN
cord-326960-9phlylce	247	33	to	to	IN
cord-326960-9phlylce	247	34	more	more	JJR
cord-326960-9phlylce	247	35	than	than	IN
cord-326960-9phlylce	247	36	20	20	CD
cord-326960-9phlylce	247	37	countries	country	NNS
cord-326960-9phlylce	247	38	or	or	CC
cord-326960-9phlylce	247	39	jurisdictions	jurisdiction	NNS
cord-326960-9phlylce	247	40	in	in	IN
cord-326960-9phlylce	247	41	the	the	DT
cord-326960-9phlylce	247	42	Americas	Americas	NNPS
cord-326960-9phlylce	247	43	,	,	,
cord-326960-9phlylce	247	44	including	include	VBG
cord-326960-9phlylce	247	45	the	the	DT
cord-326960-9phlylce	247	46	continental	continental	JJ
cord-326960-9phlylce	247	47	United	United	NNP
cord-326960-9phlylce	247	48	States	States	NNP
cord-326960-9phlylce	247	49	[	[	-LRB-
cord-326960-9phlylce	247	50	108	108	CD
cord-326960-9phlylce	247	51	]	]	-RRB-
cord-326960-9phlylce	247	52	.	.	.
cord-326960-9phlylce	248	1	Chikungunya	chikungunya	NN
cord-326960-9phlylce	248	2	is	be	VBZ
cord-326960-9phlylce	248	3	an	an	DT
cord-326960-9phlylce	248	4	arbovirus	arbovirus	NN
cord-326960-9phlylce	248	5	,	,	,
cord-326960-9phlylce	248	6	for	for	IN
cord-326960-9phlylce	248	7	which	which	WDT
cord-326960-9phlylce	248	8	there	there	EX
cord-326960-9phlylce	248	9	are	be	VBP
cord-326960-9phlylce	248	10	many	many	JJ
cord-326960-9phlylce	248	11	opportunities	opportunity	NNS
cord-326960-9phlylce	248	12	to	to	TO
cord-326960-9phlylce	248	13	develop	develop	VB
cord-326960-9phlylce	248	14	BEVS	bevs	NN
cord-326960-9phlylce	248	15	-	-	HYPH
cord-326960-9phlylce	248	16	derived	derive	VBN
cord-326960-9phlylce	248	17	vaccines	vaccine	NNS
cord-326960-9phlylce	248	18	(	(	-LRB-
cord-326960-9phlylce	248	19	reviewed	review	VBN
cord-326960-9phlylce	248	20	in	in	IN
cord-326960-9phlylce	248	21	[	[	-LRB-
cord-326960-9phlylce	248	22	39	39	CD
cord-326960-9phlylce	248	23	]	]	-RRB-
cord-326960-9phlylce	248	24	)	)	-RRB-
cord-326960-9phlylce	248	25	.	.	.
cord-326960-9phlylce	249	1	Both	both	DT
cord-326960-9phlylce	249	2	subunit	subunit	NN
cord-326960-9phlylce	249	3	and	and	CC
cord-326960-9phlylce	249	4	VLP	VLP	NNP
cord-326960-9phlylce	249	5	vaccine	vaccine	NN
cord-326960-9phlylce	249	6	candidates	candidate	NNS
cord-326960-9phlylce	249	7	expressing	express	VBG
cord-326960-9phlylce	249	8	the	the	DT
cord-326960-9phlylce	249	9	chikungunya	chikungunya	NN
cord-326960-9phlylce	249	10	viral	viral	JJ
cord-326960-9phlylce	249	11	envelope	envelope	NN
cord-326960-9phlylce	249	12	glycoproteins	glycoprotein	NNS
cord-326960-9phlylce	249	13	have	have	VBP
cord-326960-9phlylce	249	14	been	be	VBN
cord-326960-9phlylce	249	15	developed	develop	VBN
cord-326960-9phlylce	249	16	using	use	VBG
cord-326960-9phlylce	249	17	BEVS	BEVS	NNP
cord-326960-9phlylce	249	18	,	,	,
cord-326960-9phlylce	249	19	with	with	IN
cord-326960-9phlylce	249	20	VLPs	vlp	NNS
cord-326960-9phlylce	249	21	demonstrating	demonstrate	VBG
cord-326960-9phlylce	249	22	higher	high	JJR
cord-326960-9phlylce	249	23	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	249	24	in	in	IN
cord-326960-9phlylce	249	25	mice	mouse	NNS
cord-326960-9phlylce	249	26	[	[	-LRB-
cord-326960-9phlylce	249	27	109	109	CD
cord-326960-9phlylce	249	28	]	]	-RRB-
cord-326960-9phlylce	250	1	[	[	-LRB-
cord-326960-9phlylce	250	2	110	110	CD
cord-326960-9phlylce	250	3	]	]	-RRB-
cord-326960-9phlylce	250	4	[	[	-LRB-
cord-326960-9phlylce	250	5	111	111	CD
cord-326960-9phlylce	250	6	]	]	-RRB-
cord-326960-9phlylce	250	7	.	.	.
cord-326960-9phlylce	251	1	Ebola	Ebola	NNP
cord-326960-9phlylce	251	2	virus	virus	NN
cord-326960-9phlylce	251	3	is	be	VBZ
cord-326960-9phlylce	251	4	a	a	DT
cord-326960-9phlylce	251	5	filovirus	filovirus	NN
cord-326960-9phlylce	251	6	that	that	WDT
cord-326960-9phlylce	251	7	causes	cause	VBZ
cord-326960-9phlylce	251	8	lethal	lethal	JJ
cord-326960-9phlylce	251	9	hemorrhagic	hemorrhagic	JJ
cord-326960-9phlylce	251	10	fever	fever	NN
cord-326960-9phlylce	251	11	in	in	IN
cord-326960-9phlylce	251	12	humans	human	NNS
cord-326960-9phlylce	251	13	and	and	CC
cord-326960-9phlylce	251	14	is	be	VBZ
cord-326960-9phlylce	251	15	devastating	devastate	VBG
cord-326960-9phlylce	251	16	Africa	Africa	NNP
cord-326960-9phlylce	251	17	in	in	IN
cord-326960-9phlylce	251	18	an	an	DT
cord-326960-9phlylce	251	19	ongoing	ongoing	JJ
cord-326960-9phlylce	251	20	outbreak	outbreak	NN
cord-326960-9phlylce	251	21	[	[	-LRB-
cord-326960-9phlylce	251	22	112	112	CD
cord-326960-9phlylce	251	23	]	]	-RRB-
cord-326960-9phlylce	251	24	.	.	.
cord-326960-9phlylce	252	1	The	the	DT
cord-326960-9phlylce	252	2	Ebola	Ebola	NNP
cord-326960-9phlylce	252	3	virus	virus	NN
cord-326960-9phlylce	252	4	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	252	5	has	have	VBZ
cord-326960-9phlylce	252	6	been	be	VBN
cord-326960-9phlylce	252	7	shown	show	VBN
cord-326960-9phlylce	252	8	to	to	TO
cord-326960-9phlylce	252	9	be	be	VB
cord-326960-9phlylce	252	10	the	the	DT
cord-326960-9phlylce	252	11	protective	protective	JJ
cord-326960-9phlylce	252	12	antigen	antigen	NN
cord-326960-9phlylce	252	13	and	and	CC
cord-326960-9phlylce	252	14	could	could	MD
cord-326960-9phlylce	252	15	be	be	VB
cord-326960-9phlylce	252	16	produced	produce	VBN
cord-326960-9phlylce	252	17	similar	similar	JJ
cord-326960-9phlylce	252	18	to	to	IN
cord-326960-9phlylce	252	19	a	a	DT
cord-326960-9phlylce	252	20	chikungunya	chikungunya	NN
cord-326960-9phlylce	252	21	virus	virus	NN
cord-326960-9phlylce	252	22	vaccine	vaccine	NN
cord-326960-9phlylce	252	23	[	[	-LRB-
cord-326960-9phlylce	252	24	113	113	CD
cord-326960-9phlylce	252	25	]	]	-RRB-
cord-326960-9phlylce	252	26	.	.	.
cord-326960-9phlylce	253	1	In	in	IN
cord-326960-9phlylce	253	2	addition	addition	NN
cord-326960-9phlylce	253	3	to	to	IN
cord-326960-9phlylce	253	4	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	253	5	-	-	HYPH
cord-326960-9phlylce	253	6	based	base	VBN
cord-326960-9phlylce	253	7	vaccines	vaccine	NNS
cord-326960-9phlylce	253	8	,	,	,
cord-326960-9phlylce	253	9	the	the	DT
cord-326960-9phlylce	253	10	BEVS	BEVS	NNP
cord-326960-9phlylce	253	11	platform	platform	NN
cord-326960-9phlylce	253	12	has	have	VBZ
cord-326960-9phlylce	253	13	shown	show	VBN
cord-326960-9phlylce	253	14	early	early	JJ
cord-326960-9phlylce	253	15	promise	promise	NN
cord-326960-9phlylce	253	16	for	for	IN
cord-326960-9phlylce	253	17	the	the	DT
cord-326960-9phlylce	253	18	production	production	NN
cord-326960-9phlylce	253	19	of	of	IN
cord-326960-9phlylce	253	20	Biotechnology	Biotechnology	NNP
cord-326960-9phlylce	253	21	Journal	Journal	NNP
cord-326960-9phlylce	253	22	toxin	toxin	NN
cord-326960-9phlylce	253	23	-	-	HYPH
cord-326960-9phlylce	253	24	based	base	VBN
cord-326960-9phlylce	253	25	vaccines	vaccine	NNS
cord-326960-9phlylce	253	26	.	.	.
cord-326960-9phlylce	254	1	For	for	IN
cord-326960-9phlylce	254	2	example	example	NN
cord-326960-9phlylce	254	3	,	,	,
cord-326960-9phlylce	254	4	the	the	DT
cord-326960-9phlylce	254	5	C	C	NNP
cord-326960-9phlylce	254	6	-	-	HYPH
cord-326960-9phlylce	254	7	terminal	terminal	JJ
cord-326960-9phlylce	254	8	heavy	heavy	JJ
cord-326960-9phlylce	254	9	chain	chain	NN
cord-326960-9phlylce	254	10	domain	domain	NN
cord-326960-9phlylce	254	11	of	of	IN
cord-326960-9phlylce	254	12	clostridial	clostridial	JJ
cord-326960-9phlylce	254	13	botulinum	botulinum	NN
cord-326960-9phlylce	254	14	neurotoxin	neurotoxin	NN
cord-326960-9phlylce	254	15	,	,	,
cord-326960-9phlylce	254	16	a	a	DT
cord-326960-9phlylce	254	17	highly	highly	RB
cord-326960-9phlylce	254	18	toxic	toxic	JJ
cord-326960-9phlylce	254	19	protein	protein	NN
cord-326960-9phlylce	254	20	that	that	WDT
cord-326960-9phlylce	254	21	causes	cause	VBZ
cord-326960-9phlylce	254	22	botulism	botulism	NN
cord-326960-9phlylce	254	23	,	,	,
cord-326960-9phlylce	254	24	has	have	VBZ
cord-326960-9phlylce	254	25	been	be	VBN
cord-326960-9phlylce	254	26	produced	produce	VBN
cord-326960-9phlylce	254	27	with	with	IN
cord-326960-9phlylce	254	28	BEVS	BEVS	NNP
cord-326960-9phlylce	254	29	and	and	CC
cord-326960-9phlylce	254	30	has	have	VBZ
cord-326960-9phlylce	254	31	demonstrated	demonstrate	VBN
cord-326960-9phlylce	254	32	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	254	33	and	and	CC
cord-326960-9phlylce	254	34	challenge	challenge	NN
cord-326960-9phlylce	254	35	protection	protection	NN
cord-326960-9phlylce	254	36	in	in	IN
cord-326960-9phlylce	254	37	mice	mouse	NNS
cord-326960-9phlylce	254	38	[	[	-LRB-
cord-326960-9phlylce	254	39	114	114	CD
cord-326960-9phlylce	254	40	,	,	,
cord-326960-9phlylce	254	41	115	115	CD
cord-326960-9phlylce	254	42	]	]	-RRB-
cord-326960-9phlylce	254	43	.	.	.
cord-326960-9phlylce	255	1	Recombinant	recombinant	JJ
cord-326960-9phlylce	255	2	toxin	toxin	NN
cord-326960-9phlylce	255	3	vaccines	vaccine	NNS
cord-326960-9phlylce	255	4	for	for	IN
cord-326960-9phlylce	255	5	other	other	JJ
cord-326960-9phlylce	255	6	diseases	disease	NNS
cord-326960-9phlylce	255	7	such	such	JJ
cord-326960-9phlylce	255	8	as	as	IN
cord-326960-9phlylce	255	9	Clostridium	clostridium	NN
cord-326960-9phlylce	255	10	difficile	difficile	NN
cord-326960-9phlylce	255	11	could	could	MD
cord-326960-9phlylce	255	12	also	also	RB
cord-326960-9phlylce	255	13	be	be	VB
cord-326960-9phlylce	255	14	possible	possible	JJ
cord-326960-9phlylce	255	15	[	[	-LRB-
cord-326960-9phlylce	255	16	116	116	CD
cord-326960-9phlylce	255	17	,	,	,
cord-326960-9phlylce	255	18	117	117	CD
cord-326960-9phlylce	255	19	]	]	-RRB-
cord-326960-9phlylce	255	20	.	.	.
cord-326960-9phlylce	256	1	In	in	IN
cord-326960-9phlylce	256	2	conclusion	conclusion	NN
cord-326960-9phlylce	256	3	,	,	,
cord-326960-9phlylce	256	4	BEVS	BEVS	NNP
cord-326960-9phlylce	256	5	is	be	VBZ
cord-326960-9phlylce	256	6	a	a	DT
cord-326960-9phlylce	256	7	versatile	versatile	JJ
cord-326960-9phlylce	256	8	platform	platform	NN
cord-326960-9phlylce	256	9	whose	whose	WP$
cord-326960-9phlylce	256	10	potential	potential	NN
cord-326960-9phlylce	256	11	is	be	VBZ
cord-326960-9phlylce	256	12	just	just	RB
cord-326960-9phlylce	256	13	beginning	begin	VBG
cord-326960-9phlylce	256	14	to	to	TO
cord-326960-9phlylce	256	15	be	be	VB
cord-326960-9phlylce	256	16	realized	realize	VBN
cord-326960-9phlylce	256	17	.	.	.
cord-326960-9phlylce	257	1	The	the	DT
cord-326960-9phlylce	257	2	technology	technology	NN
cord-326960-9phlylce	257	3	offers	offer	VBZ
cord-326960-9phlylce	257	4	speed	speed	NN
cord-326960-9phlylce	257	5	,	,	,
cord-326960-9phlylce	257	6	flexibility	flexibility	NN
cord-326960-9phlylce	257	7	,	,	,
cord-326960-9phlylce	257	8	specificity	specificity	NN
cord-326960-9phlylce	257	9	and	and	CC
cord-326960-9phlylce	257	10	safety	safety	NN
cord-326960-9phlylce	257	11	,	,	,
cord-326960-9phlylce	257	12	and	and	CC
cord-326960-9phlylce	257	13	the	the	DT
cord-326960-9phlylce	257	14	use	use	NN
cord-326960-9phlylce	257	15	of	of	IN
cord-326960-9phlylce	257	16	a	a	DT
cord-326960-9phlylce	257	17	single	single	JJ
cord-326960-9phlylce	257	18	cell	cell	NN
cord-326960-9phlylce	257	19	line	line	NN
cord-326960-9phlylce	257	20	to	to	TO
cord-326960-9phlylce	257	21	manufacture	manufacture	VB
cord-326960-9phlylce	257	22	multiple	multiple	JJ
cord-326960-9phlylce	257	23	products	product	NNS
cord-326960-9phlylce	257	24	makes	make	VBZ
cord-326960-9phlylce	257	25	BEVS	BEVS	NNP
cord-326960-9phlylce	257	26	an	an	DT
cord-326960-9phlylce	257	27	attractive	attractive	JJ
cord-326960-9phlylce	257	28	platform	platform	NN
cord-326960-9phlylce	257	29	to	to	TO
cord-326960-9phlylce	257	30	adopt	adopt	VB
cord-326960-9phlylce	257	31	.	.	.
cord-326960-9phlylce	258	1	BEVS	BEVS	NNP
cord-326960-9phlylce	258	2	can	can	MD
cord-326960-9phlylce	258	3	be	be	VB
cord-326960-9phlylce	258	4	used	use	VBN
cord-326960-9phlylce	258	5	to	to	TO
cord-326960-9phlylce	258	6	develop	develop	VB
cord-326960-9phlylce	258	7	a	a	DT
cord-326960-9phlylce	258	8	wide	wide	JJ
cord-326960-9phlylce	258	9	variety	variety	NN
cord-326960-9phlylce	258	10	of	of	IN
cord-326960-9phlylce	258	11	products	product	NNS
cord-326960-9phlylce	258	12	and	and	CC
cord-326960-9phlylce	258	13	is	be	VBZ
cord-326960-9phlylce	258	14	especially	especially	RB
cord-326960-9phlylce	258	15	well	well	RB
cord-326960-9phlylce	258	16	suited	suited	JJ
cord-326960-9phlylce	258	17	for	for	IN
cord-326960-9phlylce	258	18	combating	combat	VBG
cord-326960-9phlylce	258	19	rapidly	rapidly	RB
cord-326960-9phlylce	258	20	emerging	emerge	VBG
cord-326960-9phlylce	258	21	and	and	CC
cord-326960-9phlylce	258	22	dangerous	dangerous	JJ
cord-326960-9phlylce	258	23	pathogens	pathogen	NNS
cord-326960-9phlylce	258	24	.	.	.
cord-326960-9phlylce	259	1	With	with	IN
cord-326960-9phlylce	259	2	new	new	JJ
cord-326960-9phlylce	259	3	threats	threat	NNS
cord-326960-9phlylce	259	4	continually	continually	RB
cord-326960-9phlylce	259	5	on	on	IN
cord-326960-9phlylce	259	6	the	the	DT
cord-326960-9phlylce	259	7	rise	rise	NN
cord-326960-9phlylce	259	8	,	,	,
cord-326960-9phlylce	259	9	tools	tool	NNS
cord-326960-9phlylce	259	10	such	such	JJ
cord-326960-9phlylce	259	11	as	as	IN
cord-326960-9phlylce	259	12	BEVS	BEVS	NNP
cord-326960-9phlylce	259	13	offer	offer	VBP
cord-326960-9phlylce	259	14	an	an	DT
cord-326960-9phlylce	259	15	important	important	JJ
cord-326960-9phlylce	259	16	defense	defense	NN
cord-326960-9phlylce	259	17	.	.	.
cord-326960-9phlylce	260	1	The	the	DT
cord-326960-9phlylce	260	2	author	author	NN
cord-326960-9phlylce	260	3	works	work	VBZ
cord-326960-9phlylce	260	4	for	for	IN
cord-326960-9phlylce	260	5	Protein	Protein	NNP
cord-326960-9phlylce	260	6	Sciences	Sciences	NNPS
cord-326960-9phlylce	260	7	Corporation	Corporation	NNP
cord-326960-9phlylce	260	8	,	,	,
cord-326960-9phlylce	260	9	which	which	WDT
cord-326960-9phlylce	260	10	has	have	VBZ
cord-326960-9phlylce	260	11	a	a	DT
cord-326960-9phlylce	260	12	financial	financial	JJ
cord-326960-9phlylce	260	13	interest	interest	NN
cord-326960-9phlylce	260	14	in	in	IN
cord-326960-9phlylce	260	15	BEVS	BEVS	NNP
cord-326960-9phlylce	260	16	and	and	CC
cord-326960-9phlylce	260	17	manufactures	manufacture	VBZ
cord-326960-9phlylce	260	18	Flublok	Flublok	NNP
cord-326960-9phlylce	260	19	®	®	POS
cord-326960-9phlylce	260	20	influenza	influenza	NN
cord-326960-9phlylce	260	21	vaccine	vaccine	NN
cord-326960-9phlylce	260	22	.	.	.
cord-326960-9phlylce	261	1	Recombinant	recombinant	JJ
cord-326960-9phlylce	261	2	protein	protein	NN
cord-326960-9phlylce	261	3	vaccines	vaccine	NNS
cord-326960-9phlylce	261	4	produced	produce	VBN
cord-326960-9phlylce	261	5	in	in	IN
cord-326960-9phlylce	261	6	insect	insect	NN
cord-326960-9phlylce	261	7	cells	cell	NNS
cord-326960-9phlylce	261	8	Vaccines	vaccine	NNS
cord-326960-9phlylce	261	9	for	for	IN
cord-326960-9phlylce	261	10	viral	viral	JJ
cord-326960-9phlylce	261	11	and	and	CC
cord-326960-9phlylce	261	12	parasitic	parasitic	JJ
cord-326960-9phlylce	261	13	diseases	disease	NNS
cord-326960-9phlylce	261	14	produced	produce	VBN
cord-326960-9phlylce	261	15	with	with	IN
cord-326960-9phlylce	261	16	baculovirus	baculovirus	NNP
cord-326960-9phlylce	261	17	vectors	vector	NNS
cord-326960-9phlylce	261	18	Commercial	commercial	JJ
cord-326960-9phlylce	261	19	production	production	NN
cord-326960-9phlylce	261	20	in	in	IN
cord-326960-9phlylce	261	21	insect	insect	NN
cord-326960-9phlylce	261	22	cells	cell	NNS
cord-326960-9phlylce	261	23	.	.	.
cord-326960-9phlylce	262	1	One	one	CD
cord-326960-9phlylce	262	2	company	company	NN
cord-326960-9phlylce	262	3	's	's	POS
cord-326960-9phlylce	262	4	perspective	perspective	NN
cord-326960-9phlylce	262	5	Production	production	NN
cord-326960-9phlylce	262	6	of	of	IN
cord-326960-9phlylce	262	7	recombinant	recombinant	JJ
cord-326960-9phlylce	262	8	proteins	protein	NNS
cord-326960-9phlylce	262	9	by	by	IN
cord-326960-9phlylce	262	10	microbes	microbe	NNS
cord-326960-9phlylce	262	11	and	and	CC
cord-326960-9phlylce	262	12	higher	high	JJR
cord-326960-9phlylce	262	13	organisms	organism	NNS
cord-326960-9phlylce	263	1	A	a	DT
cord-326960-9phlylce	263	2	fast	fast	JJ
cord-326960-9phlylce	263	3	track	track	NN
cord-326960-9phlylce	263	4	influenza	influenza	NN
cord-326960-9phlylce	263	5	virus	virus	NN
cord-326960-9phlylce	263	6	vaccine	vaccine	NN
cord-326960-9phlylce	263	7	produced	produce	VBN
cord-326960-9phlylce	263	8	in	in	IN
cord-326960-9phlylce	263	9	insect	insect	NN
cord-326960-9phlylce	263	10	cells	cell	NNS
cord-326960-9phlylce	263	11	Insect	insect	NN
cord-326960-9phlylce	263	12	cell	cell	NN
cord-326960-9phlylce	263	13	technology	technology	NN
cord-326960-9phlylce	263	14	is	be	VBZ
cord-326960-9phlylce	263	15	a	a	DT
cord-326960-9phlylce	263	16	versatile	versatile	JJ
cord-326960-9phlylce	263	17	and	and	CC
cord-326960-9phlylce	263	18	robust	robust	JJ
cord-326960-9phlylce	263	19	vaccine	vaccine	NN
cord-326960-9phlylce	263	20	manufacturing	manufacture	VBG
cord-326960-9phlylce	263	21	platform	platform	NN
cord-326960-9phlylce	263	22	Opportunities	opportunity	NNS
cord-326960-9phlylce	263	23	and	and	CC
cord-326960-9phlylce	263	24	challenges	challenge	NNS
cord-326960-9phlylce	263	25	for	for	IN
cord-326960-9phlylce	263	26	the	the	DT
cord-326960-9phlylce	263	27	baculovirus	baculovirus	NNP
cord-326960-9phlylce	263	28	expression	expression	NN
cord-326960-9phlylce	263	29	system	system	NN
cord-326960-9phlylce	263	30	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	263	31	-	-	HYPH
cord-326960-9phlylce	263	32	insect	insect	NN
cord-326960-9phlylce	263	33	cell	cell	NN
cord-326960-9phlylce	263	34	expression	expression	NN
cord-326960-9phlylce	263	35	systems	system	NNS
cord-326960-9phlylce	263	36	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	263	37	as	as	IN
cord-326960-9phlylce	263	38	a	a	DT
cord-326960-9phlylce	263	39	highly	highly	RB
cord-326960-9phlylce	263	40	efficient	efficient	JJ
cord-326960-9phlylce	263	41	expression	expression	NN
cord-326960-9phlylce	263	42	vector	vector	NN
cord-326960-9phlylce	263	43	in	in	IN
cord-326960-9phlylce	263	44	insect	insect	NN
cord-326960-9phlylce	263	45	and	and	CC
cord-326960-9phlylce	263	46	mammalian	mammalian	JJ
cord-326960-9phlylce	263	47	cells	cell	NNS
cord-326960-9phlylce	264	1	The	the	DT
cord-326960-9phlylce	264	2	complete	complete	JJ
cord-326960-9phlylce	264	3	DNA	dna	NN
cord-326960-9phlylce	264	4	sequence	sequence	NN
cord-326960-9phlylce	264	5	of	of	IN
cord-326960-9phlylce	264	6	Autographa	Autographa	NNP
cord-326960-9phlylce	264	7	californica	californica	NNP
cord-326960-9phlylce	264	8	nuclear	nuclear	JJ
cord-326960-9phlylce	264	9	polyhedrosis	polyhedrosis	NN
cord-326960-9phlylce	264	10	virus	virus	NN
cord-326960-9phlylce	264	11	Production	Production	NNP
cord-326960-9phlylce	264	12	of	of	IN
cord-326960-9phlylce	264	13	human	human	JJ
cord-326960-9phlylce	264	14	beta	beta	NN
cord-326960-9phlylce	264	15	interferon	interferon	NN
cord-326960-9phlylce	264	16	in	in	IN
cord-326960-9phlylce	264	17	insect	insect	NN
cord-326960-9phlylce	264	18	cells	cell	NNS
cord-326960-9phlylce	264	19	infected	infect	VBN
cord-326960-9phlylce	264	20	with	with	IN
cord-326960-9phlylce	264	21	a	a	DT
cord-326960-9phlylce	264	22	baculovirus	baculovirus	NN
cord-326960-9phlylce	264	23	expression	expression	NN
cord-326960-9phlylce	264	24	vector	vector	NN
cord-326960-9phlylce	265	1	A	a	DT
cord-326960-9phlylce	265	2	baculovirus	baculovirus	NN
cord-326960-9phlylce	265	3	dual	dual	JJ
cord-326960-9phlylce	265	4	expression	expression	NN
cord-326960-9phlylce	265	5	vector	vector	NN
cord-326960-9phlylce	265	6	derived	derive	VBN
cord-326960-9phlylce	265	7	from	from	IN
cord-326960-9phlylce	265	8	the	the	DT
cord-326960-9phlylce	265	9	Autographa	Autographa	NNP
cord-326960-9phlylce	265	10	californica	californica	NNP
cord-326960-9phlylce	265	11	nuclear	nuclear	JJ
cord-326960-9phlylce	265	12	polyhedrosis	polyhedrosis	NN
cord-326960-9phlylce	265	13	virus	virus	NN
cord-326960-9phlylce	265	14	polyhedrin	polyhedrin	NNP
cord-326960-9phlylce	265	15	and	and	CC
cord-326960-9phlylce	265	16	p10	p10	NN
cord-326960-9phlylce	265	17	promoters	promoter	NNS
cord-326960-9phlylce	265	18	:	:	:
cord-326960-9phlylce	265	19	Co	co	NN
cord-326960-9phlylce	265	20	-	-	NN
cord-326960-9phlylce	265	21	expression	expression	NN
cord-326960-9phlylce	265	22	of	of	IN
cord-326960-9phlylce	265	23	two	two	CD
cord-326960-9phlylce	265	24	influenza	influenza	NN
cord-326960-9phlylce	265	25	virus	virus	NN
cord-326960-9phlylce	265	26	genes	gene	NNS
cord-326960-9phlylce	265	27	in	in	IN
cord-326960-9phlylce	265	28	insect	insect	NN
cord-326960-9phlylce	265	29	cells	cell	VBZ
cord-326960-9phlylce	265	30	A	a	DT
cord-326960-9phlylce	265	31	method	method	NN
cord-326960-9phlylce	265	32	for	for	IN
cord-326960-9phlylce	265	33	producing	produce	VBG
cord-326960-9phlylce	265	34	recombinant	recombinant	JJ
cord-326960-9phlylce	265	35	baculovirus	baculovirus	NN
cord-326960-9phlylce	265	36	expression	expression	NN
cord-326960-9phlylce	265	37	vectors	vector	NNS
cord-326960-9phlylce	265	38	at	at	IN
cord-326960-9phlylce	265	39	high	high	JJ
cord-326960-9phlylce	265	40	frequency	frequency	NN
cord-326960-9phlylce	265	41	Spontaneous	spontaneous	JJ
cord-326960-9phlylce	265	42	excision	excision	NN
cord-326960-9phlylce	265	43	of	of	IN
cord-326960-9phlylce	265	44	BAC	BAC	NNP
cord-326960-9phlylce	265	45	vector	vector	NN
cord-326960-9phlylce	265	46	sequences	sequence	NNS
cord-326960-9phlylce	265	47	from	from	IN
cord-326960-9phlylce	265	48	bacmid	bacmid	NNP
cord-326960-9phlylce	265	49	-	-	HYPH
cord-326960-9phlylce	265	50	derived	derive	VBN
cord-326960-9phlylce	265	51	baculovirus	baculovirus	NN
cord-326960-9phlylce	265	52	expression	expression	NN
cord-326960-9phlylce	265	53	vectors	vector	NNS
cord-326960-9phlylce	265	54	upon	upon	IN
cord-326960-9phlylce	265	55	passage	passage	NN
cord-326960-9phlylce	265	56	in	in	IN
cord-326960-9phlylce	265	57	insect	insect	NN
cord-326960-9phlylce	265	58	cells	cell	NNS
cord-326960-9phlylce	266	1	The	the	DT
cord-326960-9phlylce	266	2	establishment	establishment	NN
cord-326960-9phlylce	266	3	of	of	IN
cord-326960-9phlylce	266	4	two	two	CD
cord-326960-9phlylce	266	5	cell	cell	NN
cord-326960-9phlylce	266	6	lines	line	NNS
cord-326960-9phlylce	266	7	from	from	IN
cord-326960-9phlylce	266	8	the	the	DT
cord-326960-9phlylce	266	9	insect	insect	NN
cord-326960-9phlylce	266	10	Spodoptera	Spodoptera	NNP
cord-326960-9phlylce	266	11	frugiperda	frugiperda	NN
cord-326960-9phlylce	266	12	(	(	-LRB-
cord-326960-9phlylce	266	13	Lepidoptera	Lepidoptera	NNP
cord-326960-9phlylce	266	14	;	;	:
cord-326960-9phlylce	266	15	Noctuidae	Noctuidae	NNP
cord-326960-9phlylce	266	16	)	)	-RRB-
cord-326960-9phlylce	266	17	Screening	screening	NN
cord-326960-9phlylce	266	18	of	of	IN
cord-326960-9phlylce	266	19	insect	insect	NN
cord-326960-9phlylce	266	20	cell	cell	NN
cord-326960-9phlylce	266	21	lines	line	NNS
cord-326960-9phlylce	266	22	for	for	IN
cord-326960-9phlylce	266	23	the	the	DT
cord-326960-9phlylce	266	24	production	production	NN
cord-326960-9phlylce	266	25	of	of	IN
cord-326960-9phlylce	266	26	recombinant	recombinant	JJ
cord-326960-9phlylce	266	27	proteins	protein	NNS
cord-326960-9phlylce	266	28	and	and	CC
cord-326960-9phlylce	266	29	infectious	infectious	JJ
cord-326960-9phlylce	266	30	virus	virus	NN
cord-326960-9phlylce	266	31	in	in	IN
cord-326960-9phlylce	266	32	the	the	DT
cord-326960-9phlylce	266	33	baculovirus	baculovirus	NNP
cord-326960-9phlylce	266	34	expression	expression	NN
cord-326960-9phlylce	266	35	system	system	NN
cord-326960-9phlylce	267	1	Traditional	traditional	JJ
cord-326960-9phlylce	267	2	and	and	CC
cord-326960-9phlylce	267	3	new	new	JJ
cord-326960-9phlylce	267	4	influenza	influenza	NN
cord-326960-9phlylce	267	5	vaccines	vaccine	NNS
cord-326960-9phlylce	267	6	Molecular	Molecular	NNP
cord-326960-9phlylce	267	7	mechanisms	mechanism	NNS
cord-326960-9phlylce	267	8	enhancing	enhance	VBG
cord-326960-9phlylce	267	9	the	the	DT
cord-326960-9phlylce	267	10	proteome	proteome	NN
cord-326960-9phlylce	267	11	of	of	IN
cord-326960-9phlylce	267	12	influenza	influenza	NN
cord-326960-9phlylce	267	13	A	a	DT
cord-326960-9phlylce	267	14	viruses	virus	NNS
cord-326960-9phlylce	267	15	:	:	:
cord-326960-9phlylce	268	1	An	an	DT
cord-326960-9phlylce	268	2	overview	overview	NN
cord-326960-9phlylce	268	3	of	of	IN
cord-326960-9phlylce	268	4	recently	recently	RB
cord-326960-9phlylce	268	5	discovered	discover	VBN
cord-326960-9phlylce	268	6	proteins	protein	NNS
cord-326960-9phlylce	268	7	Low	Low	NNP
cord-326960-9phlylce	268	8	2012	2012	CD
cord-326960-9phlylce	268	9	-	-	SYM
cord-326960-9phlylce	268	10	13	13	CD
cord-326960-9phlylce	268	11	influenza	influenza	NN
cord-326960-9phlylce	268	12	vaccine	vaccine	NN
cord-326960-9phlylce	268	13	effectiveness	effectiveness	NN
cord-326960-9phlylce	268	14	associated	associate	VBN
cord-326960-9phlylce	268	15	with	with	IN
cord-326960-9phlylce	268	16	mutation	mutation	NN
cord-326960-9phlylce	268	17	in	in	IN
cord-326960-9phlylce	268	18	the	the	DT
cord-326960-9phlylce	268	19	egg	egg	NN
cord-326960-9phlylce	268	20	-	-	HYPH
cord-326960-9phlylce	268	21	adapted	adapt	VBN
cord-326960-9phlylce	268	22	H3N2	H3N2	NNP
cord-326960-9phlylce	268	23	vaccine	vaccine	NN
cord-326960-9phlylce	268	24	strain	strain	NN
cord-326960-9phlylce	268	25	not	not	RB
cord-326960-9phlylce	268	26	antigenic	antigenic	JJ
cord-326960-9phlylce	268	27	drift	drift	NN
cord-326960-9phlylce	268	28	in	in	IN
cord-326960-9phlylce	268	29	circulating	circulate	VBG
cord-326960-9phlylce	268	30	viruses	virus	NNS
cord-326960-9phlylce	268	31	Mechanism	Mechanism	NNP
cord-326960-9phlylce	268	32	of	of	IN
cord-326960-9phlylce	268	33	a	a	DT
cord-326960-9phlylce	268	34	decrease	decrease	NN
cord-326960-9phlylce	268	35	in	in	IN
cord-326960-9phlylce	268	36	potency	potency	NN
cord-326960-9phlylce	268	37	for	for	IN
cord-326960-9phlylce	268	38	the	the	DT
cord-326960-9phlylce	268	39	recombinant	recombinant	JJ
cord-326960-9phlylce	268	40	influenza	influenza	NN
cord-326960-9phlylce	268	41	a	a	DT
cord-326960-9phlylce	268	42	virus	virus	NN
cord-326960-9phlylce	268	43	hemagglutinin	hemagglutinin	VBN
cord-326960-9phlylce	268	44	H3	H3	NNP
cord-326960-9phlylce	268	45	antigen	antigen	NN
cord-326960-9phlylce	268	46	during	during	IN
cord-326960-9phlylce	268	47	storage	storage	NN
cord-326960-9phlylce	268	48	Modifications	modification	NNS
cord-326960-9phlylce	268	49	of	of	IN
cord-326960-9phlylce	268	50	cysteine	cysteine	NN
cord-326960-9phlylce	268	51	residues	residue	NNS
cord-326960-9phlylce	268	52	in	in	IN
cord-326960-9phlylce	268	53	the	the	DT
cord-326960-9phlylce	268	54	transmembrane	transmembrane	NN
cord-326960-9phlylce	268	55	and	and	CC
cord-326960-9phlylce	268	56	cytoplasmic	cytoplasmic	JJ
cord-326960-9phlylce	268	57	domains	domain	NNS
cord-326960-9phlylce	268	58	of	of	IN
cord-326960-9phlylce	268	59	a	a	DT
cord-326960-9phlylce	268	60	recombinant	recombinant	JJ
cord-326960-9phlylce	268	61	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	268	62	protein	protein	NN
cord-326960-9phlylce	268	63	prevents	prevent	VBZ
cord-326960-9phlylce	268	64	cross	cross	RB
cord-326960-9phlylce	268	65	-	-	JJ
cord-326960-9phlylce	268	66	linked	link	VBN
cord-326960-9phlylce	268	67	multimer	multimer	NN
cord-326960-9phlylce	268	68	formation	formation	NN
cord-326960-9phlylce	268	69	and	and	CC
cord-326960-9phlylce	268	70	potency	potency	NN
cord-326960-9phlylce	268	71	loss	loss	NN
cord-326960-9phlylce	268	72	Prevention	Prevention	NNP
cord-326960-9phlylce	268	73	and	and	CC
cord-326960-9phlylce	268	74	control	control	NN
cord-326960-9phlylce	268	75	of	of	IN
cord-326960-9phlylce	268	76	seasonal	seasonal	JJ
cord-326960-9phlylce	268	77	influenza	influenza	NN
cord-326960-9phlylce	268	78	with	with	IN
cord-326960-9phlylce	268	79	vaccines	vaccine	NNS
cord-326960-9phlylce	268	80	Antigenic	antigenic	JJ
cord-326960-9phlylce	268	81	and	and	CC
cord-326960-9phlylce	268	82	genetic	genetic	JJ
cord-326960-9phlylce	268	83	characteristics	characteristic	NNS
cord-326960-9phlylce	268	84	of	of	IN
cord-326960-9phlylce	268	85	swine	swine	NN
cord-326960-9phlylce	268	86	-	-	HYPH
cord-326960-9phlylce	268	87	origin	origin	NN
cord-326960-9phlylce	268	88	2009	2009	CD
cord-326960-9phlylce	268	89	A(H1N1	a(h1n1	CD
cord-326960-9phlylce	268	90	)	)	-RRB-
cord-326960-9phlylce	269	1	influenza	influenza	NN
cord-326960-9phlylce	269	2	viruses	virus	NNS
cord-326960-9phlylce	269	3	circulating	circulate	VBG
cord-326960-9phlylce	269	4	in	in	IN
cord-326960-9phlylce	269	5	humans	human	NNS
cord-326960-9phlylce	269	6	Pandemic	Pandemic	NNP
cord-326960-9phlylce	269	7	novel	novel	JJ
cord-326960-9phlylce	269	8	2009	2009	CD
cord-326960-9phlylce	270	1	H1N1	H1N1	NNP
cord-326960-9phlylce	270	2	influenza	influenza	NN
cord-326960-9phlylce	270	3	:	:	:
cord-326960-9phlylce	270	4	What	what	WP
cord-326960-9phlylce	270	5	have	have	VBP
cord-326960-9phlylce	270	6	we	-PRON-	PRP
cord-326960-9phlylce	270	7	learned	learn	VBN
cord-326960-9phlylce	270	8	?	?	.
cord-326960-9phlylce	271	1	Semin	Semin	NNP
cord-326960-9phlylce	271	2	.	.	.
cord-326960-9phlylce	272	1	Respir	Respir	NNP
cord-326960-9phlylce	272	2	Impact	Impact	NNP
cord-326960-9phlylce	272	3	of	of	IN
cord-326960-9phlylce	272	4	influenza	influenza	NN
cord-326960-9phlylce	272	5	B	b	NN
cord-326960-9phlylce	272	6	lineagelevel	lineagelevel	NNP
cord-326960-9phlylce	272	7	mismatch	mismatch	NN
cord-326960-9phlylce	272	8	between	between	IN
cord-326960-9phlylce	272	9	trivalent	trivalent	JJ
cord-326960-9phlylce	272	10	seasonal	seasonal	JJ
cord-326960-9phlylce	272	11	influenza	influenza	NN
cord-326960-9phlylce	272	12	vaccines	vaccine	NNS
cord-326960-9phlylce	272	13	and	and	CC
cord-326960-9phlylce	272	14	circulating	circulate	VBG
cord-326960-9phlylce	272	15	viruses	virus	NNS
cord-326960-9phlylce	273	1	Influenza	Influenza	NNP
cord-326960-9phlylce	273	2	vaccine	vaccine	NN
cord-326960-9phlylce	273	3	:	:	:
cord-326960-9phlylce	274	1	The	the	DT
cord-326960-9phlylce	274	2	challenge	challenge	NN
cord-326960-9phlylce	274	3	of	of	IN
cord-326960-9phlylce	274	4	antigenic	antigenic	JJ
cord-326960-9phlylce	274	5	drift	drift	NN
cord-326960-9phlylce	274	6	Molecular	Molecular	NNP
cord-326960-9phlylce	274	7	and	and	CC
cord-326960-9phlylce	274	8	structural	structural	JJ
cord-326960-9phlylce	274	9	characterization	characterization	NN
cord-326960-9phlylce	274	10	of	of	IN
cord-326960-9phlylce	274	11	the	the	DT
cord-326960-9phlylce	274	12	L1	L1	NNP
cord-326960-9phlylce	274	13	virus	virus	NN
cord-326960-9phlylce	274	14	-	-	HYPH
cord-326960-9phlylce	274	15	like	like	JJ
cord-326960-9phlylce	274	16	particles	particle	NNS
cord-326960-9phlylce	274	17	that	that	WDT
cord-326960-9phlylce	274	18	are	be	VBP
cord-326960-9phlylce	274	19	used	use	VBN
cord-326960-9phlylce	274	20	as	as	IN
cord-326960-9phlylce	274	21	vaccine	vaccine	NN
cord-326960-9phlylce	274	22	antigens	antigen	NNS
cord-326960-9phlylce	274	23	in	in	IN
cord-326960-9phlylce	274	24	Cervarix	Cervarix	NNP
cord-326960-9phlylce	274	25	,	,	,
cord-326960-9phlylce	274	26	the	the	DT
cord-326960-9phlylce	274	27	AS04-adjuvanted	AS04-adjuvanted	NNP
cord-326960-9phlylce	274	28	HPV-16	HPV-16	NNP
cord-326960-9phlylce	274	29	and	and	CC
cord-326960-9phlylce	274	30	-18	-18	NFP
cord-326960-9phlylce	274	31	cervical	cervical	JJ
cord-326960-9phlylce	274	32	cancer	cancer	NN
cord-326960-9phlylce	274	33	vaccine	vaccine	NN
cord-326960-9phlylce	274	34	A	a	DT
cord-326960-9phlylce	274	35	recombinant	recombinant	JJ
cord-326960-9phlylce	274	36	baculovirus	baculovirus	NN
cord-326960-9phlylce	274	37	-	-	HYPH
cord-326960-9phlylce	274	38	expressed	express	VBN
cord-326960-9phlylce	274	39	S	S	NNP
cord-326960-9phlylce	274	40	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	274	41	vaccine	vaccine	NN
cord-326960-9phlylce	274	42	elicits	elicit	VBZ
cord-326960-9phlylce	274	43	high	high	JJ
cord-326960-9phlylce	274	44	titers	titer	NNS
cord-326960-9phlylce	274	45	of	of	IN
cord-326960-9phlylce	274	46	SARS	SARS	NNP
cord-326960-9phlylce	274	47	-	-	HYPH
cord-326960-9phlylce	274	48	associated	associate	VBN
cord-326960-9phlylce	274	49	coronavirus	coronavirus	NN
cord-326960-9phlylce	274	50	(	(	-LRB-
cord-326960-9phlylce	275	1	SARS	SARS	NNP
cord-326960-9phlylce	275	2	-	-	HYPH
cord-326960-9phlylce	275	3	CoV	CoV	NNP
cord-326960-9phlylce	275	4	)	)	-RRB-
cord-326960-9phlylce	275	5	neutralizing	neutralize	VBG
cord-326960-9phlylce	275	6	antibodies	antibody	NNS
cord-326960-9phlylce	275	7	in	in	IN
cord-326960-9phlylce	275	8	mice	mouse	NNS
cord-326960-9phlylce	276	1	A	a	DT
cord-326960-9phlylce	276	2	designer	designer	NN
cord-326960-9phlylce	276	3	hyper	hyper	NN
cord-326960-9phlylce	276	4	interleukin	interleukin	NN
cord-326960-9phlylce	276	5	11	11	CD
cord-326960-9phlylce	276	6	(	(	-LRB-
cord-326960-9phlylce	276	7	H11	H11	NNP
cord-326960-9phlylce	276	8	)	)	-RRB-
cord-326960-9phlylce	276	9	is	be	VBZ
cord-326960-9phlylce	276	10	a	a	DT
cord-326960-9phlylce	276	11	biologically	biologically	RB
cord-326960-9phlylce	276	12	active	active	JJ
cord-326960-9phlylce	276	13	cytokine	cytokine	NN
cord-326960-9phlylce	276	14	A	a	DT
cord-326960-9phlylce	276	15	vaccine	vaccine	NN
cord-326960-9phlylce	276	16	of	of	IN
cord-326960-9phlylce	276	17	L2	L2	NNP
cord-326960-9phlylce	276	18	epitope	epitope	NN
cord-326960-9phlylce	276	19	repeats	repeat	VBZ
cord-326960-9phlylce	276	20	fused	fuse	VBN
cord-326960-9phlylce	276	21	with	with	IN
cord-326960-9phlylce	277	1	a	a	DT
cord-326960-9phlylce	277	2	modified	modify	VBN
cord-326960-9phlylce	277	3	IgG1	IgG1	NNP
cord-326960-9phlylce	277	4	Fc	Fc	NNP
cord-326960-9phlylce	277	5	induced	induce	VBD
cord-326960-9phlylce	277	6	cross	cross	NN
cord-326960-9phlylce	277	7	-	-	JJ
cord-326960-9phlylce	277	8	neutralizing	neutralize	VBG
cord-326960-9phlylce	277	9	antibodies	antibody	NNS
cord-326960-9phlylce	277	10	and	and	CC
cord-326960-9phlylce	277	11	protective	protective	JJ
cord-326960-9phlylce	277	12	immunity	immunity	NN
cord-326960-9phlylce	277	13	against	against	IN
cord-326960-9phlylce	277	14	divergent	divergent	JJ
cord-326960-9phlylce	277	15	human	human	JJ
cord-326960-9phlylce	277	16	papillomavirus	papillomavirus	NN
cord-326960-9phlylce	277	17	types	type	NNS
cord-326960-9phlylce	277	18	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	277	19	vector	vector	NN
cord-326960-9phlylce	277	20	as	as	IN
cord-326960-9phlylce	277	21	an	an	DT
cord-326960-9phlylce	277	22	avian	avian	JJ
cord-326960-9phlylce	277	23	influenza	influenza	NN
cord-326960-9phlylce	277	24	vaccine	vaccine	NN
cord-326960-9phlylce	277	25	:	:	:
cord-326960-9phlylce	277	26	Hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	277	27	expression	expression	NN
cord-326960-9phlylce	277	28	and	and	CC
cord-326960-9phlylce	277	29	presentation	presentation	NN
cord-326960-9phlylce	277	30	augment	augment	VB
cord-326960-9phlylce	277	31	the	the	DT
cord-326960-9phlylce	277	32	vaccine	vaccine	NN
cord-326960-9phlylce	277	33	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	277	34	PROVENGE	PROVENGE	NNP
cord-326960-9phlylce	278	1	(	(	-LRB-
cord-326960-9phlylce	278	2	Sipuleucel	Sipuleucel	NNP
cord-326960-9phlylce	278	3	-	-	HYPH
cord-326960-9phlylce	278	4	T	T	NNP
cord-326960-9phlylce	278	5	)	)	-RRB-
cord-326960-9phlylce	278	6	in	in	IN
cord-326960-9phlylce	278	7	prostate	prostate	NN
cord-326960-9phlylce	278	8	cancer	cancer	NN
cord-326960-9phlylce	278	9	:	:	:
cord-326960-9phlylce	279	1	The	the	DT
cord-326960-9phlylce	279	2	first	first	JJ
cord-326960-9phlylce	279	3	FDA	FDA	NNP
cord-326960-9phlylce	279	4	-	-	HYPH
cord-326960-9phlylce	279	5	approved	approve	VBN
cord-326960-9phlylce	279	6	therapeutic	therapeutic	JJ
cord-326960-9phlylce	279	7	cancer	cancer	NN
cord-326960-9phlylce	279	8	vaccine	vaccine	NN
cord-326960-9phlylce	280	1	The	the	DT
cord-326960-9phlylce	280	2	presence	presence	NN
cord-326960-9phlylce	280	3	of	of	IN
cord-326960-9phlylce	280	4	nuclear	nuclear	JJ
cord-326960-9phlylce	280	5	polyhedrosis	polyhedrosis	NN
cord-326960-9phlylce	280	6	viruses	virus	NNS
cord-326960-9phlylce	280	7	of	of	IN
cord-326960-9phlylce	280	8	Trichoplusia	Trichoplusia	NNP
cord-326960-9phlylce	280	9	ni	ni	NNP
cord-326960-9phlylce	280	10	on	on	IN
cord-326960-9phlylce	280	11	cabbage	cabbage	NN
cord-326960-9phlylce	280	12	from	from	IN
cord-326960-9phlylce	280	13	the	the	DT
cord-326960-9phlylce	280	14	market	market	NN
cord-326960-9phlylce	280	15	shelf	shelf	NN
cord-326960-9phlylce	281	1	In	in	IN
cord-326960-9phlylce	281	2	vitro	vitro	FW
cord-326960-9phlylce	281	3	survey	survey	NN
cord-326960-9phlylce	281	4	of	of	IN
cord-326960-9phlylce	281	5	Autographa	Autographa	NNP
cord-326960-9phlylce	281	6	californica	californica	NNP
cord-326960-9phlylce	281	7	nuclear	nuclear	JJ
cord-326960-9phlylce	281	8	polyhedrosis	polyhedrosis	NNP
cord-326960-9phlylce	281	9	virus	virus	NN
cord-326960-9phlylce	281	10	interaction	interaction	NN
cord-326960-9phlylce	281	11	with	with	IN
cord-326960-9phlylce	281	12	nontarget	nontarget	NNP
cord-326960-9phlylce	281	13	vertebrate	vertebrate	JJ
cord-326960-9phlylce	281	14	host	host	NN
cord-326960-9phlylce	281	15	cells	cell	NNS
cord-326960-9phlylce	282	1	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	282	2	-	-	HYPH
cord-326960-9phlylce	282	3	mediated	mediate	VBN
cord-326960-9phlylce	282	4	expression	expression	NN
cord-326960-9phlylce	282	5	of	of	IN
cord-326960-9phlylce	282	6	bacterial	bacterial	JJ
cord-326960-9phlylce	282	7	genes	gene	NNS
cord-326960-9phlylce	282	8	in	in	IN
cord-326960-9phlylce	282	9	dipteran	dipteran	NN
cord-326960-9phlylce	282	10	and	and	CC
cord-326960-9phlylce	282	11	mammalian	mammalian	JJ
cord-326960-9phlylce	282	12	cells	cell	NNS
cord-326960-9phlylce	282	13	Efficient	efficient	JJ
cord-326960-9phlylce	282	14	gene	gene	NN
cord-326960-9phlylce	282	15	transfer	transfer	NN
cord-326960-9phlylce	282	16	into	into	IN
cord-326960-9phlylce	282	17	human	human	JJ
cord-326960-9phlylce	282	18	hepatocytes	hepatocyte	NNS
cord-326960-9phlylce	282	19	by	by	IN
cord-326960-9phlylce	282	20	baculovirus	baculovirus	NNP
cord-326960-9phlylce	282	21	vectors	vector	NNS
cord-326960-9phlylce	282	22	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	282	23	-	-	HYPH
cord-326960-9phlylce	282	24	mediated	mediate	VBN
cord-326960-9phlylce	282	25	gene	gene	NN
cord-326960-9phlylce	282	26	transfer	transfer	NN
cord-326960-9phlylce	282	27	into	into	IN
cord-326960-9phlylce	282	28	mammalian	mammalian	JJ
cord-326960-9phlylce	282	29	cells	cell	NNS
cord-326960-9phlylce	282	30	Arbovirus	Arbovirus	NNP
cord-326960-9phlylce	282	31	vaccines	vaccine	NNS
cord-326960-9phlylce	282	32	;	;	:
cord-326960-9phlylce	282	33	opportunities	opportunity	NNS
cord-326960-9phlylce	282	34	for	for	IN
cord-326960-9phlylce	282	35	the	the	DT
cord-326960-9phlylce	282	36	baculovirus	baculovirus	NN
cord-326960-9phlylce	282	37	-	-	HYPH
cord-326960-9phlylce	282	38	insect	insect	NN
cord-326960-9phlylce	282	39	cell	cell	NN
cord-326960-9phlylce	282	40	expression	expression	NN
cord-326960-9phlylce	282	41	system	system	NN
cord-326960-9phlylce	283	1	Latent	latent	JJ
cord-326960-9phlylce	283	2	infection	infection	NN
cord-326960-9phlylce	283	3	of	of	IN
cord-326960-9phlylce	283	4	a	a	DT
cord-326960-9phlylce	283	5	new	new	JJ
cord-326960-9phlylce	283	6	alphanodavirus	alphanodavirus	NN
cord-326960-9phlylce	283	7	in	in	IN
cord-326960-9phlylce	283	8	an	an	DT
cord-326960-9phlylce	283	9	insect	insect	NN
cord-326960-9phlylce	283	10	cell	cell	NN
cord-326960-9phlylce	283	11	line	line	NN
cord-326960-9phlylce	284	1	Gypsy	gypsy	JJ
cord-326960-9phlylce	284	2	endogenous	endogenous	JJ
cord-326960-9phlylce	284	3	retrovirus	retrovirus	NN
cord-326960-9phlylce	284	4	maintains	maintain	VBZ
cord-326960-9phlylce	284	5	potential	potential	JJ
cord-326960-9phlylce	284	6	infectivity	infectivity	NN
cord-326960-9phlylce	284	7	in	in	IN
cord-326960-9phlylce	284	8	several	several	JJ
cord-326960-9phlylce	284	9	species	specie	NNS
cord-326960-9phlylce	284	10	of	of	IN
cord-326960-9phlylce	284	11	Drosophilids	Drosophilids	NNP
cord-326960-9phlylce	284	12	Identification	Identification	NNP
cord-326960-9phlylce	284	13	of	of	IN
cord-326960-9phlylce	284	14	a	a	DT
cord-326960-9phlylce	284	15	novel	novel	JJ
cord-326960-9phlylce	284	16	rhabdovirus	rhabdovirus	NN
cord-326960-9phlylce	284	17	in	in	IN
cord-326960-9phlylce	284	18	Spodoptera	Spodoptera	NNP
cord-326960-9phlylce	284	19	frugiperda	frugiperda	JJ
cord-326960-9phlylce	284	20	cell	cell	NN
cord-326960-9phlylce	284	21	lines	line	NNS
cord-326960-9phlylce	284	22	Mammalian	mammalian	JJ
cord-326960-9phlylce	284	23	stable	stable	JJ
cord-326960-9phlylce	284	24	expression	expression	NN
cord-326960-9phlylce	284	25	of	of	IN
cord-326960-9phlylce	284	26	biotherapeutics	biotherapeutic	NNS
cord-326960-9phlylce	284	27	Technology	Technology	NNP
cord-326960-9phlylce	284	28	transfer	transfer	NN
cord-326960-9phlylce	284	29	and	and	CC
cord-326960-9phlylce	284	30	scale	scale	NN
cord-326960-9phlylce	284	31	-	-	HYPH
cord-326960-9phlylce	284	32	up	up	NN
cord-326960-9phlylce	284	33	of	of	IN
cord-326960-9phlylce	284	34	the	the	DT
cord-326960-9phlylce	284	35	Flublok	Flublok	NNP
cord-326960-9phlylce	284	36	®	®	POS
cord-326960-9phlylce	284	37	recombinant	recombinant	JJ
cord-326960-9phlylce	284	38	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	284	39	(	(	-LRB-
cord-326960-9phlylce	284	40	HA	HA	NNP
cord-326960-9phlylce	284	41	)	)	-RRB-
cord-326960-9phlylce	284	42	influenza	influenza	NN
cord-326960-9phlylce	284	43	vaccine	vaccine	NN
cord-326960-9phlylce	284	44	manufacturing	manufacturing	NN
cord-326960-9phlylce	284	45	process	process	NN
cord-326960-9phlylce	284	46	Vaccine	Vaccine	NNP
cord-326960-9phlylce	284	47	process	process	NN
cord-326960-9phlylce	284	48	technology	technology	NN
cord-326960-9phlylce	284	49	Thirty	thirty	CD
cord-326960-9phlylce	284	50	years	year	NNS
cord-326960-9phlylce	284	51	of	of	IN
cord-326960-9phlylce	284	52	baculovirus	baculovirus	NN
cord-326960-9phlylce	284	53	-	-	HYPH
cord-326960-9phlylce	284	54	insect	insect	NN
cord-326960-9phlylce	284	55	cell	cell	NN
cord-326960-9phlylce	284	56	protein	protein	NN
cord-326960-9phlylce	284	57	expression	expression	NN
cord-326960-9phlylce	284	58	:	:	:
cord-326960-9phlylce	284	59	From	from	IN
cord-326960-9phlylce	284	60	dark	dark	JJ
cord-326960-9phlylce	284	61	horse	horse	NN
cord-326960-9phlylce	284	62	to	to	IN
cord-326960-9phlylce	284	63	mainstream	mainstream	NN
cord-326960-9phlylce	284	64	technology	technology	NN
cord-326960-9phlylce	284	65	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	284	66	as	as	IN
cord-326960-9phlylce	284	67	versatile	versatile	JJ
cord-326960-9phlylce	284	68	vectors	vector	NNS
cord-326960-9phlylce	284	69	for	for	IN
cord-326960-9phlylce	284	70	protein	protein	NN
cord-326960-9phlylce	284	71	expression	expression	NN
cord-326960-9phlylce	284	72	in	in	IN
cord-326960-9phlylce	284	73	insect	insect	NN
cord-326960-9phlylce	284	74	and	and	CC
cord-326960-9phlylce	284	75	mammalian	mammalian	JJ
cord-326960-9phlylce	284	76	cells	cell	NNS
cord-326960-9phlylce	284	77	Transforming	transform	VBG
cord-326960-9phlylce	284	78	lepidopteran	lepidopteran	JJ
cord-326960-9phlylce	284	79	insect	insect	NN
cord-326960-9phlylce	284	80	cells	cell	NNS
cord-326960-9phlylce	284	81	for	for	IN
cord-326960-9phlylce	284	82	improved	improved	JJ
cord-326960-9phlylce	284	83	protein	protein	NN
cord-326960-9phlylce	284	84	processing	process	VBG
cord-326960-9phlylce	284	85	N	N	NNP
cord-326960-9phlylce	284	86	-	-	HYPH
cord-326960-9phlylce	284	87	Glycosylation	Glycosylation	NNP
cord-326960-9phlylce	284	88	engineering	engineering	NN
cord-326960-9phlylce	284	89	of	of	IN
cord-326960-9phlylce	284	90	lepidopteran	lepidopteran	JJ
cord-326960-9phlylce	284	91	insect	insect	NN
cord-326960-9phlylce	284	92	cells	cell	NNS
cord-326960-9phlylce	284	93	by	by	IN
cord-326960-9phlylce	284	94	the	the	DT
cord-326960-9phlylce	284	95	introduction	introduction	NN
cord-326960-9phlylce	284	96	of	of	IN
cord-326960-9phlylce	284	97	the	the	DT
cord-326960-9phlylce	284	98	beta1,4-N	beta1,4-N	NNP
cord-326960-9phlylce	284	99	-	-	HYPH
cord-326960-9phlylce	284	100	acetylglucosaminyltransferase	acetylglucosaminyltransferase	NNP
cord-326960-9phlylce	284	101	III	III	NNP
cord-326960-9phlylce	284	102	gene	gene	NN
cord-326960-9phlylce	284	103	A	a	DT
cord-326960-9phlylce	284	104	transgenic	transgenic	JJ
cord-326960-9phlylce	284	105	insect	insect	NN
cord-326960-9phlylce	284	106	cell	cell	NN
cord-326960-9phlylce	284	107	line	line	NN
cord-326960-9phlylce	284	108	engineered	engineer	VBN
cord-326960-9phlylce	284	109	to	to	TO
cord-326960-9phlylce	284	110	produce	produce	VB
cord-326960-9phlylce	284	111	CMP	cmp	NN
cord-326960-9phlylce	284	112	-	-	HYPH
cord-326960-9phlylce	284	113	sialic	sialic	NN
cord-326960-9phlylce	284	114	acid	acid	NN
cord-326960-9phlylce	284	115	and	and	CC
cord-326960-9phlylce	284	116	sialylated	sialylate	VBN
cord-326960-9phlylce	284	117	glycoproteins	glycoprotein	NNS
cord-326960-9phlylce	284	118	SweetBac	SweetBac	NNP
cord-326960-9phlylce	284	119	:	:	:
cord-326960-9phlylce	284	120	A	a	DT
cord-326960-9phlylce	284	121	new	new	JJ
cord-326960-9phlylce	284	122	approach	approach	NN
cord-326960-9phlylce	284	123	for	for	IN
cord-326960-9phlylce	284	124	the	the	DT
cord-326960-9phlylce	284	125	production	production	NN
cord-326960-9phlylce	284	126	of	of	IN
cord-326960-9phlylce	284	127	mammalianised	mammalianised	JJ
cord-326960-9phlylce	284	128	glycoproteins	glycoprotein	NNS
cord-326960-9phlylce	284	129	in	in	IN
cord-326960-9phlylce	284	130	insect	insect	NN
cord-326960-9phlylce	284	131	cells	cell	NNS
cord-326960-9phlylce	285	1	Recombinant	recombinant	JJ
cord-326960-9phlylce	285	2	adeno	adeno	NN
cord-326960-9phlylce	285	3	-	-	HYPH
cord-326960-9phlylce	285	4	associated	associate	VBN
cord-326960-9phlylce	285	5	virus	virus	NN
cord-326960-9phlylce	285	6	transduction	transduction	NN
cord-326960-9phlylce	285	7	and	and	CC
cord-326960-9phlylce	285	8	integration	integration	NN
cord-326960-9phlylce	286	1	New	new	JJ
cord-326960-9phlylce	286	2	developments	development	NNS
cord-326960-9phlylce	286	3	in	in	IN
cord-326960-9phlylce	286	4	the	the	DT
cord-326960-9phlylce	286	5	use	use	NN
cord-326960-9phlylce	286	6	of	of	IN
cord-326960-9phlylce	286	7	gene	gene	NN
cord-326960-9phlylce	286	8	therapy	therapy	NN
cord-326960-9phlylce	287	1	to	to	TO
cord-326960-9phlylce	287	2	treat	treat	VB
cord-326960-9phlylce	287	3	Duchenne	Duchenne	NNP
cord-326960-9phlylce	287	4	muscular	muscular	JJ
cord-326960-9phlylce	287	5	dystrophy	dystrophy	NN
cord-326960-9phlylce	287	6	Analysis	Analysis	NNP
cord-326960-9phlylce	287	7	of	of	IN
cord-326960-9phlylce	287	8	AAV	AAV	NNP
cord-326960-9phlylce	287	9	serotypes	serotype	NNS
cord-326960-9phlylce	287	10	1	1	CD
cord-326960-9phlylce	287	11	-	-	SYM
cord-326960-9phlylce	287	12	9	9	CD
cord-326960-9phlylce	287	13	mediated	mediate	VBN
cord-326960-9phlylce	287	14	gene	gene	NN
cord-326960-9phlylce	287	15	expression	expression	NN
cord-326960-9phlylce	287	16	and	and	CC
cord-326960-9phlylce	287	17	tropism	tropism	NN
cord-326960-9phlylce	287	18	in	in	IN
cord-326960-9phlylce	287	19	mice	mouse	NNS
cord-326960-9phlylce	287	20	after	after	IN
cord-326960-9phlylce	287	21	systemic	systemic	JJ
cord-326960-9phlylce	287	22	injection	injection	NN
cord-326960-9phlylce	287	23	Insect	insect	NN
cord-326960-9phlylce	287	24	cells	cell	NNS
cord-326960-9phlylce	287	25	as	as	IN
cord-326960-9phlylce	287	26	a	a	DT
cord-326960-9phlylce	287	27	factory	factory	NN
cord-326960-9phlylce	287	28	to	to	TO
cord-326960-9phlylce	287	29	produce	produce	VB
cord-326960-9phlylce	287	30	adeno	adeno	NN
cord-326960-9phlylce	287	31	-	-	HYPH
cord-326960-9phlylce	287	32	associated	associate	VBN
cord-326960-9phlylce	287	33	virus	virus	NN
cord-326960-9phlylce	287	34	type	type	NN
cord-326960-9phlylce	287	35	2	2	CD
cord-326960-9phlylce	287	36	vectors	vector	NNS
cord-326960-9phlylce	287	37	.	.	.
cord-326960-9phlylce	288	1	Hum	Hum	NNP
cord-326960-9phlylce	288	2	A	a	DT
cord-326960-9phlylce	288	3	simplified	simplified	JJ
cord-326960-9phlylce	288	4	baculovirus	baculovirus	NNP
cord-326960-9phlylce	288	5	-	-	HYPH
cord-326960-9phlylce	288	6	AAV	AAV	NNP
cord-326960-9phlylce	288	7	expression	expression	NN
cord-326960-9phlylce	288	8	vector	vector	NN
cord-326960-9phlylce	288	9	system	system	NN
cord-326960-9phlylce	288	10	coupled	couple	VBN
cord-326960-9phlylce	288	11	with	with	IN
cord-326960-9phlylce	288	12	one	one	CD
cord-326960-9phlylce	288	13	-	-	HYPH
cord-326960-9phlylce	288	14	step	step	NN
cord-326960-9phlylce	288	15	affinity	affinity	NN
cord-326960-9phlylce	288	16	purification	purification	NN
cord-326960-9phlylce	288	17	yields	yield	VBZ
cord-326960-9phlylce	288	18	high	high	JJ
cord-326960-9phlylce	288	19	-	-	HYPH
cord-326960-9phlylce	288	20	titer	titer	NN
cord-326960-9phlylce	288	21	rAAV	rAAV	NNS
cord-326960-9phlylce	288	22	stocks	stock	NNS
cord-326960-9phlylce	288	23	from	from	IN
cord-326960-9phlylce	288	24	insect	insect	NN
cord-326960-9phlylce	288	25	cells	cell	NNS
cord-326960-9phlylce	288	26	Improving	improve	VBG
cord-326960-9phlylce	288	27	adeno	adeno	NN
cord-326960-9phlylce	288	28	-	-	HYPH
cord-326960-9phlylce	288	29	associated	associate	VBN
cord-326960-9phlylce	288	30	vector	vector	NN
cord-326960-9phlylce	288	31	yield	yield	NN
cord-326960-9phlylce	288	32	in	in	IN
cord-326960-9phlylce	288	33	high	high	JJ
cord-326960-9phlylce	288	34	density	density	NN
cord-326960-9phlylce	288	35	insect	insect	NN
cord-326960-9phlylce	288	36	cell	cell	NN
cord-326960-9phlylce	288	37	cultures	culture	NNS
cord-326960-9phlylce	289	1	Successful	successful	JJ
cord-326960-9phlylce	289	2	production	production	NN
cord-326960-9phlylce	289	3	of	of	IN
cord-326960-9phlylce	289	4	pseudotyped	pseudotyped	NNP
cord-326960-9phlylce	289	5	rAAV	rAAV	NNP
cord-326960-9phlylce	289	6	vectors	vector	NNS
cord-326960-9phlylce	289	7	using	use	VBG
cord-326960-9phlylce	289	8	a	a	DT
cord-326960-9phlylce	289	9	modified	modify	VBN
cord-326960-9phlylce	289	10	baculovirus	baculovirus	NN
cord-326960-9phlylce	289	11	expression	expression	NN
cord-326960-9phlylce	289	12	system	system	NN
cord-326960-9phlylce	290	1	Economized	economize	VBN
cord-326960-9phlylce	290	2	large	large	JJ
cord-326960-9phlylce	290	3	-	-	HYPH
cord-326960-9phlylce	290	4	scale	scale	NN
cord-326960-9phlylce	290	5	production	production	NN
cord-326960-9phlylce	290	6	of	of	IN
cord-326960-9phlylce	290	7	high	high	JJ
cord-326960-9phlylce	290	8	yield	yield	NN
cord-326960-9phlylce	290	9	of	of	IN
cord-326960-9phlylce	290	10	rAAV	raav	NN
cord-326960-9phlylce	290	11	for	for	IN
cord-326960-9phlylce	290	12	gene	gene	NN
cord-326960-9phlylce	290	13	therapy	therapy	NN
cord-326960-9phlylce	290	14	applications	application	NNS
cord-326960-9phlylce	290	15	exploiting	exploit	VBG
cord-326960-9phlylce	290	16	baculovirus	baculovirus	NNP
cord-326960-9phlylce	290	17	expression	expression	NN
cord-326960-9phlylce	290	18	system	system	NN
cord-326960-9phlylce	290	19	Removal	Removal	NNP
cord-326960-9phlylce	290	20	of	of	IN
cord-326960-9phlylce	290	21	empty	empty	JJ
cord-326960-9phlylce	290	22	capsids	capsid	NNS
cord-326960-9phlylce	290	23	from	from	IN
cord-326960-9phlylce	290	24	type	type	NN
cord-326960-9phlylce	290	25	1	1	CD
cord-326960-9phlylce	290	26	adeno	adeno	NN
cord-326960-9phlylce	290	27	-	-	HYPH
cord-326960-9phlylce	290	28	associated	associate	VBN
cord-326960-9phlylce	290	29	virus	virus	NN
cord-326960-9phlylce	290	30	vector	vector	NN
cord-326960-9phlylce	290	31	stocks	stock	NNS
cord-326960-9phlylce	290	32	by	by	IN
cord-326960-9phlylce	290	33	anion	anion	NN
cord-326960-9phlylce	290	34	-	-	HYPH
cord-326960-9phlylce	290	35	exchange	exchange	NN
cord-326960-9phlylce	290	36	chromatography	chromatography	NN
cord-326960-9phlylce	290	37	potentiates	potentiate	VBZ
cord-326960-9phlylce	290	38	transgene	transgene	JJ
cord-326960-9phlylce	290	39	expression	expression	NN
cord-326960-9phlylce	290	40	Toward	toward	IN
cord-326960-9phlylce	290	41	exascale	exascale	JJ
cord-326960-9phlylce	290	42	production	production	NN
cord-326960-9phlylce	290	43	of	of	IN
cord-326960-9phlylce	290	44	recombinant	recombinant	JJ
cord-326960-9phlylce	290	45	adeno	adeno	NN
cord-326960-9phlylce	290	46	-	-	HYPH
cord-326960-9phlylce	290	47	associated	associate	VBN
cord-326960-9phlylce	290	48	virus	virus	NN
cord-326960-9phlylce	290	49	for	for	IN
cord-326960-9phlylce	290	50	gene	gene	NN
cord-326960-9phlylce	290	51	transfer	transfer	NN
cord-326960-9phlylce	290	52	applications	application	NNS
cord-326960-9phlylce	290	53	Producing	produce	VBG
cord-326960-9phlylce	290	54	recombinant	recombinant	JJ
cord-326960-9phlylce	290	55	adenoassociated	adenoassociate	VBN
cord-326960-9phlylce	290	56	virus	virus	NN
cord-326960-9phlylce	290	57	in	in	IN
cord-326960-9phlylce	290	58	foster	foster	JJ
cord-326960-9phlylce	290	59	cells	cell	NNS
cord-326960-9phlylce	290	60	:	:	:
cord-326960-9phlylce	290	61	Overcoming	overcome	VBG
cord-326960-9phlylce	290	62	production	production	NN
cord-326960-9phlylce	290	63	limitations	limitation	NNS
cord-326960-9phlylce	290	64	using	use	VBG
cord-326960-9phlylce	290	65	a	a	DT
cord-326960-9phlylce	290	66	baculovirus	baculovirus	NN
cord-326960-9phlylce	290	67	-	-	HYPH
cord-326960-9phlylce	290	68	insect	insect	NN
cord-326960-9phlylce	290	69	cell	cell	NN
cord-326960-9phlylce	290	70	expression	expression	NN
cord-326960-9phlylce	290	71	strategy	strategy	NN
cord-326960-9phlylce	290	72	.	.	.
cord-326960-9phlylce	291	1	Hum	hum	VB
cord-326960-9phlylce	291	2	Large	large	JJ
cord-326960-9phlylce	291	3	-	-	HYPH
cord-326960-9phlylce	291	4	scale	scale	NN
cord-326960-9phlylce	291	5	production	production	NN
cord-326960-9phlylce	291	6	of	of	IN
cord-326960-9phlylce	291	7	recombinant	recombinant	JJ
cord-326960-9phlylce	291	8	adeno	adeno	NN
cord-326960-9phlylce	291	9	-	-	HYPH
cord-326960-9phlylce	291	10	associated	associate	VBN
cord-326960-9phlylce	291	11	viral	viral	JJ
cord-326960-9phlylce	291	12	vectors	vector	NNS
cord-326960-9phlylce	291	13	Novel	novel	JJ
cord-326960-9phlylce	291	14	tools	tool	NNS
cord-326960-9phlylce	291	15	for	for	IN
cord-326960-9phlylce	291	16	production	production	NN
cord-326960-9phlylce	291	17	and	and	CC
cord-326960-9phlylce	291	18	purification	purification	NN
cord-326960-9phlylce	291	19	of	of	IN
cord-326960-9phlylce	291	20	recombinant	recombinant	JJ
cord-326960-9phlylce	291	21	adenoassociated	adenoassociate	VBN
cord-326960-9phlylce	291	22	virus	virus	NN
cord-326960-9phlylce	291	23	vectors	vector	NNS
cord-326960-9phlylce	291	24	Adeno	Adeno	NNP
cord-326960-9phlylce	291	25	-	-	HYPH
cord-326960-9phlylce	291	26	associated	associate	VBN
cord-326960-9phlylce	291	27	virus	virus	NN
cord-326960-9phlylce	291	28	as	as	IN
cord-326960-9phlylce	291	29	a	a	DT
cord-326960-9phlylce	291	30	gene	gene	NN
cord-326960-9phlylce	291	31	therapy	therapy	NN
cord-326960-9phlylce	291	32	vector	vector	NN
cord-326960-9phlylce	291	33	:	:	:
cord-326960-9phlylce	291	34	Vector	vector	NN
cord-326960-9phlylce	291	35	development	development	NN
cord-326960-9phlylce	291	36	,	,	,
cord-326960-9phlylce	291	37	production	production	NN
cord-326960-9phlylce	291	38	and	and	CC
cord-326960-9phlylce	291	39	clinical	clinical	JJ
cord-326960-9phlylce	291	40	applications	application	NNS
cord-326960-9phlylce	291	41	Immune	immune	VBP
cord-326960-9phlylce	291	42	responses	response	NNS
cord-326960-9phlylce	291	43	to	to	IN
cord-326960-9phlylce	291	44	AAV	AAV	NNP
cord-326960-9phlylce	291	45	-	-	HYPH
cord-326960-9phlylce	291	46	vectors	vector	NNS
cord-326960-9phlylce	291	47	,	,	,
cord-326960-9phlylce	291	48	the	the	DT
cord-326960-9phlylce	291	49	glybera	glybera	NN
cord-326960-9phlylce	291	50	example	example	NN
cord-326960-9phlylce	291	51	from	from	IN
cord-326960-9phlylce	291	52	bench	bench	NN
cord-326960-9phlylce	291	53	to	to	IN
cord-326960-9phlylce	291	54	bedside	bedside	NN
cord-326960-9phlylce	291	55	Safety	Safety	NNP
cord-326960-9phlylce	291	56	profile	profile	NN
cord-326960-9phlylce	291	57	of	of	IN
cord-326960-9phlylce	291	58	recombinant	recombinant	JJ
cord-326960-9phlylce	291	59	adeno	adeno	NN
cord-326960-9phlylce	291	60	-	-	HYPH
cord-326960-9phlylce	291	61	associated	associate	VBN
cord-326960-9phlylce	291	62	viral	viral	JJ
cord-326960-9phlylce	291	63	vectors	vector	NNS
cord-326960-9phlylce	291	64	:	:	:
cord-326960-9phlylce	291	65	Focus	focus	VB
cord-326960-9phlylce	291	66	on	on	IN
cord-326960-9phlylce	291	67	alipogene	alipogene	JJ
cord-326960-9phlylce	291	68	tiparvovec	tiparvovec	NN
cord-326960-9phlylce	291	69	(	(	-LRB-
cord-326960-9phlylce	291	70	Glybera	Glybera	NNP
cord-326960-9phlylce	291	71	®	®	POS
cord-326960-9phlylce	291	72	)	)	-RRB-
cord-326960-9phlylce	291	73	Identification	identification	NN
cord-326960-9phlylce	291	74	of	of	IN
cord-326960-9phlylce	291	75	sequence	sequence	NN
cord-326960-9phlylce	291	76	variants	variant	NNS
cord-326960-9phlylce	291	77	in	in	IN
cord-326960-9phlylce	291	78	genetic	genetic	JJ
cord-326960-9phlylce	291	79	disease	disease	NN
cord-326960-9phlylce	291	80	-	-	HYPH
cord-326960-9phlylce	291	81	causing	cause	VBG
cord-326960-9phlylce	291	82	genes	gene	NNS
cord-326960-9phlylce	291	83	using	use	VBG
cord-326960-9phlylce	291	84	targeted	target	VBN
cord-326960-9phlylce	291	85	next	next	JJ
cord-326960-9phlylce	291	86	-	-	HYPH
cord-326960-9phlylce	291	87	generation	generation	NN
cord-326960-9phlylce	291	88	sequencing	sequence	VBG
cord-326960-9phlylce	291	89	Current	current	JJ
cord-326960-9phlylce	291	90	status	status	NN
cord-326960-9phlylce	291	91	of	of	IN
cord-326960-9phlylce	291	92	haemophilia	haemophilia	NN
cord-326960-9phlylce	291	93	gene	gene	NN
cord-326960-9phlylce	291	94	therapy	therapy	NN
cord-326960-9phlylce	291	95	Advances	advance	VBZ
cord-326960-9phlylce	291	96	in	in	IN
cord-326960-9phlylce	291	97	AAV	AAV	NNP
cord-326960-9phlylce	291	98	vector	vector	NN
cord-326960-9phlylce	291	99	development	development	NN
cord-326960-9phlylce	291	100	for	for	IN
cord-326960-9phlylce	291	101	gene	gene	NN
cord-326960-9phlylce	291	102	therapy	therapy	NN
cord-326960-9phlylce	291	103	in	in	IN
cord-326960-9phlylce	291	104	the	the	DT
cord-326960-9phlylce	291	105	retina	retina	JJ
cord-326960-9phlylce	291	106	Preclinical	Preclinical	NNP
cord-326960-9phlylce	291	107	safety	safety	NN
cord-326960-9phlylce	291	108	evaluation	evaluation	NN
cord-326960-9phlylce	291	109	of	of	IN
cord-326960-9phlylce	291	110	AAV2-sFLT01-a	aav2-sflt01-a	JJ
cord-326960-9phlylce	291	111	gene	gene	NN
cord-326960-9phlylce	291	112	therapy	therapy	NN
cord-326960-9phlylce	291	113	for	for	IN
cord-326960-9phlylce	291	114	agerelated	agerelate	VBN
cord-326960-9phlylce	291	115	macular	macular	NNP
cord-326960-9phlylce	291	116	degeneration	degeneration	NN
cord-326960-9phlylce	291	117	Adeno	Adeno	NNP
cord-326960-9phlylce	291	118	-	-	HYPH
cord-326960-9phlylce	291	119	associated	associate	VBN
cord-326960-9phlylce	291	120	virus	virus	NN
cord-326960-9phlylce	291	121	(	(	-LRB-
cord-326960-9phlylce	291	122	AAV	AAV	NNP
cord-326960-9phlylce	291	123	)	)	-RRB-
cord-326960-9phlylce	291	124	gene	gene	NN
cord-326960-9phlylce	291	125	therapy	therapy	NN
cord-326960-9phlylce	291	126	for	for	IN
cord-326960-9phlylce	291	127	neurological	neurological	JJ
cord-326960-9phlylce	291	128	disease	disease	NN
cord-326960-9phlylce	291	129	Full	full	JJ
cord-326960-9phlylce	291	130	-	-	HYPH
cord-326960-9phlylce	291	131	length	length	NN
cord-326960-9phlylce	291	132	dystrophin	dystrophin	NN
cord-326960-9phlylce	291	133	reconstitution	reconstitution	NN
cord-326960-9phlylce	291	134	with	with	IN
cord-326960-9phlylce	291	135	adeno	adeno	NNP
cord-326960-9phlylce	291	136	-	-	HYPH
cord-326960-9phlylce	291	137	associated	associate	VBN
cord-326960-9phlylce	291	138	viral	viral	JJ
cord-326960-9phlylce	291	139	vectors	vector	NNS
cord-326960-9phlylce	291	140	.	.	.
cord-326960-9phlylce	292	1	Hum	Hum	NNP
cord-326960-9phlylce	292	2	Recombinant	recombinant	JJ
cord-326960-9phlylce	292	3	trivalent	trivalent	JJ
cord-326960-9phlylce	292	4	influenza	influenza	NN
cord-326960-9phlylce	292	5	vaccine	vaccine	NN
cord-326960-9phlylce	292	6	(	(	-LRB-
cord-326960-9phlylce	292	7	Flublok	Flublok	NNP
cord-326960-9phlylce	292	8	®	®	NNP
cord-326960-9phlylce	292	9	):	):	NN
cord-326960-9phlylce	293	1	A	a	DT
cord-326960-9phlylce	293	2	review	review	NN
cord-326960-9phlylce	293	3	of	of	IN
cord-326960-9phlylce	293	4	its	-PRON-	PRP$
cord-326960-9phlylce	293	5	use	use	NN
cord-326960-9phlylce	293	6	in	in	IN
cord-326960-9phlylce	293	7	the	the	DT
cord-326960-9phlylce	293	8	prevention	prevention	NN
cord-326960-9phlylce	293	9	of	of	IN
cord-326960-9phlylce	293	10	seasonal	seasonal	JJ
cord-326960-9phlylce	293	11	influenza	influenza	NN
cord-326960-9phlylce	293	12	in	in	IN
cord-326960-9phlylce	293	13	adults	adult	NNS
cord-326960-9phlylce	293	14	Pandemic	Pandemic	NNP
cord-326960-9phlylce	293	15	influenza	influenza	NN
cord-326960-9phlylce	293	16	vaccine	vaccine	NN
cord-326960-9phlylce	293	17	:	:	:
cord-326960-9phlylce	293	18	Characterization	characterization	NN
cord-326960-9phlylce	293	19	of	of	IN
cord-326960-9phlylce	293	20	A/	A/	NNP
cord-326960-9phlylce	294	1	California/07/2009	California/07/2009	NNP
cord-326960-9phlylce	294	2	(	(	-LRB-
cord-326960-9phlylce	294	3	H1N1	H1N1	NNP
cord-326960-9phlylce	294	4	)	)	-RRB-
cord-326960-9phlylce	294	5	recombinant	recombinant	JJ
cord-326960-9phlylce	294	6	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	294	7	protein	protein	NN
cord-326960-9phlylce	294	8	and	and	CC
cord-326960-9phlylce	294	9	insights	insight	NNS
cord-326960-9phlylce	294	10	into	into	IN
cord-326960-9phlylce	294	11	H1N1	H1N1	NNP
cord-326960-9phlylce	294	12	antigen	antigen	NN
cord-326960-9phlylce	294	13	stability	stability	NN
cord-326960-9phlylce	294	14	Protective	protective	JJ
cord-326960-9phlylce	294	15	efficacy	efficacy	NN
cord-326960-9phlylce	294	16	of	of	IN
cord-326960-9phlylce	294	17	a	a	DT
cord-326960-9phlylce	294	18	trivalent	trivalent	JJ
cord-326960-9phlylce	294	19	recombinant	recombinant	JJ
cord-326960-9phlylce	294	20	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	294	21	protein	protein	NN
cord-326960-9phlylce	294	22	vaccine	vaccine	NN
cord-326960-9phlylce	294	23	(	(	-LRB-
cord-326960-9phlylce	294	24	FluBlok	FluBlok	NNP
cord-326960-9phlylce	294	25	®	®	NNPS
cord-326960-9phlylce	294	26	)	)	-RRB-
cord-326960-9phlylce	294	27	against	against	IN
cord-326960-9phlylce	294	28	influenza	influenza	NN
cord-326960-9phlylce	294	29	in	in	IN
cord-326960-9phlylce	294	30	healthy	healthy	JJ
cord-326960-9phlylce	294	31	adults	adult	NNS
cord-326960-9phlylce	294	32	:	:	:
cord-326960-9phlylce	295	1	A	a	DT
cord-326960-9phlylce	295	2	randomized	randomized	JJ
cord-326960-9phlylce	295	3	,	,	,
cord-326960-9phlylce	295	4	placebo	placebo	NN
cord-326960-9phlylce	295	5	-	-	HYPH
cord-326960-9phlylce	295	6	controlled	control	VBN
cord-326960-9phlylce	295	7	trial	trial	NN
cord-326960-9phlylce	295	8	Evaluation	Evaluation	NNP
cord-326960-9phlylce	295	9	of	of	IN
cord-326960-9phlylce	295	10	the	the	DT
cord-326960-9phlylce	295	11	safety	safety	NN
cord-326960-9phlylce	295	12	,	,	,
cord-326960-9phlylce	295	13	reactogenicity	reactogenicity	NN
cord-326960-9phlylce	295	14	and	and	CC
cord-326960-9phlylce	295	15	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	295	16	of	of	IN
cord-326960-9phlylce	295	17	FluBlok	FluBlok	NNP
cord-326960-9phlylce	295	18	®	®	NN
cord-326960-9phlylce	295	19	trivalent	trivalent	JJ
cord-326960-9phlylce	295	20	recombinant	recombinant	JJ
cord-326960-9phlylce	295	21	baculovirus	baculovirus	NNP
cord-326960-9phlylce	295	22	-	-	HYPH
cord-326960-9phlylce	295	23	expressed	express	VBN
cord-326960-9phlylce	295	24	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	295	25	influenza	influenza	NN
cord-326960-9phlylce	295	26	vaccine	vaccine	NN
cord-326960-9phlylce	295	27	administered	administer	VBN
cord-326960-9phlylce	295	28	intramuscularly	intramuscularly	RB
cord-326960-9phlylce	295	29	to	to	IN
cord-326960-9phlylce	295	30	healthy	healthy	JJ
cord-326960-9phlylce	295	31	adults	adult	NNS
cord-326960-9phlylce	295	32	50	50	CD
cord-326960-9phlylce	295	33	-	-	SYM
cord-326960-9phlylce	295	34	64	64	CD
cord-326960-9phlylce	295	35	years	year	NNS
cord-326960-9phlylce	295	36	of	of	IN
cord-326960-9phlylce	295	37	age	age	NN
cord-326960-9phlylce	295	38	Safety	safety	NN
cord-326960-9phlylce	295	39	and	and	CC
cord-326960-9phlylce	295	40	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	295	41	of	of	IN
cord-326960-9phlylce	295	42	a	a	DT
cord-326960-9phlylce	295	43	baculovirus	baculovirus	NN
cord-326960-9phlylce	295	44	-	-	HYPH
cord-326960-9phlylce	295	45	expressed	express	VBN
cord-326960-9phlylce	295	46	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	295	47	influenza	influenza	NN
cord-326960-9phlylce	295	48	vaccine	vaccine	NN
cord-326960-9phlylce	295	49	:	:	:
cord-326960-9phlylce	295	50	A	a	DT
cord-326960-9phlylce	295	51	randomized	randomized	JJ
cord-326960-9phlylce	295	52	controlled	control	VBN
cord-326960-9phlylce	295	53	trial	trial	NN
cord-326960-9phlylce	295	54	Comparative	comparative	JJ
cord-326960-9phlylce	295	55	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	295	56	of	of	IN
cord-326960-9phlylce	295	57	recombinant	recombinant	JJ
cord-326960-9phlylce	295	58	influenza	influenza	NN
cord-326960-9phlylce	295	59	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	295	60	(	(	-LRB-
cord-326960-9phlylce	295	61	rHA	rHA	NNP
cord-326960-9phlylce	295	62	)	)	-RRB-
cord-326960-9phlylce	295	63	and	and	CC
cord-326960-9phlylce	295	64	trivalent	trivalent	JJ
cord-326960-9phlylce	295	65	inactivated	inactivate	VBN
cord-326960-9phlylce	295	66	vaccine	vaccine	NN
cord-326960-9phlylce	295	67	(	(	-LRB-
cord-326960-9phlylce	295	68	TIV	TIV	NNP
cord-326960-9phlylce	295	69	)	)	-RRB-
cord-326960-9phlylce	295	70	among	among	IN
cord-326960-9phlylce	295	71	persons	person	NNS
cord-326960-9phlylce	295	72	>	>	NFP
cord-326960-9phlylce	295	73	or	or	CC
cord-326960-9phlylce	295	74	=	=	SYM
cord-326960-9phlylce	295	75	65	65	CD
cord-326960-9phlylce	295	76	years	year	NNS
cord-326960-9phlylce	295	77	old	old	JJ
cord-326960-9phlylce	295	78	Global	Global	NNP
cord-326960-9phlylce	295	79	alert	alert	NN
cord-326960-9phlylce	295	80	to	to	IN
cord-326960-9phlylce	295	81	avian	avian	JJ
cord-326960-9phlylce	295	82	influenza	influenza	NN
cord-326960-9phlylce	295	83	virus	virus	NN
cord-326960-9phlylce	295	84	infection	infection	NN
cord-326960-9phlylce	295	85	:	:	:
cord-326960-9phlylce	296	1	From	from	IN
cord-326960-9phlylce	296	2	H5N1	H5N1	NNP
cord-326960-9phlylce	296	3	to	to	IN
cord-326960-9phlylce	296	4	H7N9	H7N9	NNP
cord-326960-9phlylce	296	5	Receptor	Receptor	NNP
cord-326960-9phlylce	296	6	specificity	specificity	NN
cord-326960-9phlylce	296	7	and	and	CC
cord-326960-9phlylce	296	8	transmission	transmission	NN
cord-326960-9phlylce	296	9	of	of	IN
cord-326960-9phlylce	296	10	H2N2	H2N2	NNP
cord-326960-9phlylce	296	11	subtype	subtype	NN
cord-326960-9phlylce	296	12	viruses	virus	NNS
cord-326960-9phlylce	296	13	isolated	isolate	VBN
cord-326960-9phlylce	296	14	from	from	IN
cord-326960-9phlylce	296	15	the	the	DT
cord-326960-9phlylce	296	16	pandemic	pandemic	NN
cord-326960-9phlylce	296	17	of	of	IN
cord-326960-9phlylce	296	18	1957	1957	CD
cord-326960-9phlylce	296	19	Evaluation	Evaluation	NNP
cord-326960-9phlylce	296	20	of	of	IN
cord-326960-9phlylce	296	21	safety	safety	NN
cord-326960-9phlylce	296	22	and	and	CC
cord-326960-9phlylce	296	23	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	296	24	of	of	IN
cord-326960-9phlylce	296	25	recombinant	recombinant	JJ
cord-326960-9phlylce	296	26	influenza	influenza	NN
cord-326960-9phlylce	296	27	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	296	28	(	(	-LRB-
cord-326960-9phlylce	296	29	H5	H5	NNP
cord-326960-9phlylce	296	30	/	/	SYM
cord-326960-9phlylce	296	31	Indonesia/05/2005	Indonesia/05/2005	NNP
cord-326960-9phlylce	296	32	)	)	-RRB-
cord-326960-9phlylce	296	33	formulated	formulate	VBN
cord-326960-9phlylce	296	34	with	with	IN
cord-326960-9phlylce	296	35	and	and	CC
cord-326960-9phlylce	296	36	without	without	IN
cord-326960-9phlylce	296	37	a	a	DT
cord-326960-9phlylce	296	38	stable	stable	JJ
cord-326960-9phlylce	296	39	oil	oil	NN
cord-326960-9phlylce	296	40	-	-	HYPH
cord-326960-9phlylce	296	41	inwater	inwater	NN
cord-326960-9phlylce	296	42	emulsion	emulsion	NN
cord-326960-9phlylce	296	43	containing	contain	VBG
cord-326960-9phlylce	296	44	glucopyranosyl	glucopyranosyl	NN
cord-326960-9phlylce	296	45	-	-	HYPH
cord-326960-9phlylce	296	46	lipid	lipid	NN
cord-326960-9phlylce	296	47	A	a	NN
cord-326960-9phlylce	296	48	(	(	-LRB-
cord-326960-9phlylce	296	49	SE+GLA	SE+GLA	NNS
cord-326960-9phlylce	296	50	)	)	-RRB-
cord-326960-9phlylce	296	51	adjuvant	adjuvant	JJ
cord-326960-9phlylce	296	52	Immune	immune	JJ
cord-326960-9phlylce	296	53	responses	response	NNS
cord-326960-9phlylce	296	54	of	of	IN
cord-326960-9phlylce	296	55	healthy	healthy	JJ
cord-326960-9phlylce	296	56	subjects	subject	NNS
cord-326960-9phlylce	296	57	to	to	IN
cord-326960-9phlylce	296	58	a	a	DT
cord-326960-9phlylce	296	59	single	single	JJ
cord-326960-9phlylce	296	60	dose	dose	NN
cord-326960-9phlylce	296	61	of	of	IN
cord-326960-9phlylce	296	62	intramuscular	intramuscular	JJ
cord-326960-9phlylce	296	63	inactivated	inactivate	VBN
cord-326960-9phlylce	296	64	influenza	influenza	NN
cord-326960-9phlylce	296	65	A	A	NNP
cord-326960-9phlylce	296	66	/	/	SYM
cord-326960-9phlylce	296	67	Vietnam/1203/2004	Vietnam/1203/2004	NNP
cord-326960-9phlylce	296	68	(	(	-LRB-
cord-326960-9phlylce	296	69	H5N1	H5N1	NNP
cord-326960-9phlylce	296	70	)	)	-RRB-
cord-326960-9phlylce	296	71	vaccine	vaccine	NN
cord-326960-9phlylce	296	72	after	after	IN
cord-326960-9phlylce	296	73	priming	prime	VBG
cord-326960-9phlylce	296	74	with	with	IN
cord-326960-9phlylce	296	75	an	an	DT
cord-326960-9phlylce	296	76	antigenic	antigenic	JJ
cord-326960-9phlylce	296	77	variant	variant	NN
cord-326960-9phlylce	296	78	A	a	DT
cord-326960-9phlylce	296	79	subunit	subunit	NN
cord-326960-9phlylce	296	80	vaccine	vaccine	NN
cord-326960-9phlylce	296	81	candidate	candidate	NN
cord-326960-9phlylce	296	82	derived	derive	VBN
cord-326960-9phlylce	296	83	from	from	IN
cord-326960-9phlylce	296	84	a	a	DT
cord-326960-9phlylce	296	85	classic	classic	JJ
cord-326960-9phlylce	296	86	H5N1	H5N1	NNP
cord-326960-9phlylce	296	87	avian	avian	JJ
cord-326960-9phlylce	296	88	influenza	influenza	NN
cord-326960-9phlylce	296	89	virus	virus	NN
cord-326960-9phlylce	296	90	in	in	IN
cord-326960-9phlylce	296	91	China	China	NNP
cord-326960-9phlylce	296	92	protects	protect	VBZ
cord-326960-9phlylce	296	93	fowls	fowl	NNS
cord-326960-9phlylce	296	94	and	and	CC
cord-326960-9phlylce	296	95	BALB	BALB	NNP
cord-326960-9phlylce	296	96	/	/	SYM
cord-326960-9phlylce	296	97	c	c	NN
cord-326960-9phlylce	296	98	mice	mouse	NNS
cord-326960-9phlylce	296	99	from	from	IN
cord-326960-9phlylce	296	100	lethal	lethal	JJ
cord-326960-9phlylce	296	101	challenge	challenge	NN
cord-326960-9phlylce	296	102	H5N1	H5N1	NNP
cord-326960-9phlylce	296	103	virus	virus	NN
cord-326960-9phlylce	296	104	-	-	HYPH
cord-326960-9phlylce	296	105	like	like	JJ
cord-326960-9phlylce	296	106	particle	particle	NN
cord-326960-9phlylce	296	107	vaccine	vaccine	NN
cord-326960-9phlylce	296	108	elicits	elicit	VBZ
cord-326960-9phlylce	296	109	cross	cross	JJ
cord-326960-9phlylce	296	110	-	-	JJ
cord-326960-9phlylce	296	111	reactive	reactive	JJ
cord-326960-9phlylce	296	112	neutralizing	neutralize	VBG
cord-326960-9phlylce	296	113	antibodies	antibody	NNS
cord-326960-9phlylce	296	114	that	that	WDT
cord-326960-9phlylce	296	115	preferentially	preferentially	RB
cord-326960-9phlylce	296	116	bind	bind	VBP
cord-326960-9phlylce	296	117	to	to	IN
cord-326960-9phlylce	296	118	the	the	DT
cord-326960-9phlylce	296	119	oligomeric	oligomeric	JJ
cord-326960-9phlylce	296	120	form	form	NN
cord-326960-9phlylce	296	121	of	of	IN
cord-326960-9phlylce	296	122	influenza	influenza	NN
cord-326960-9phlylce	296	123	virus	virus	NN
cord-326960-9phlylce	296	124	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	296	125	in	in	IN
cord-326960-9phlylce	296	126	humans	human	NNS
cord-326960-9phlylce	296	127	Safety	Safety	NNP
cord-326960-9phlylce	296	128	and	and	CC
cord-326960-9phlylce	296	129	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	296	130	of	of	IN
cord-326960-9phlylce	296	131	a	a	DT
cord-326960-9phlylce	296	132	virus	virus	NN
cord-326960-9phlylce	296	133	-	-	HYPH
cord-326960-9phlylce	296	134	like	like	JJ
cord-326960-9phlylce	296	135	particle	particle	NN
cord-326960-9phlylce	296	136	pandemic	pandemic	NN
cord-326960-9phlylce	296	137	influenza	influenza	NN
cord-326960-9phlylce	296	138	A	A	NNP
cord-326960-9phlylce	296	139	(	(	-LRB-
cord-326960-9phlylce	296	140	H1N1	H1N1	NNP
cord-326960-9phlylce	296	141	)	)	-RRB-
cord-326960-9phlylce	296	142	2009	2009	CD
cord-326960-9phlylce	296	143	vaccine	vaccine	NN
cord-326960-9phlylce	296	144	in	in	IN
cord-326960-9phlylce	296	145	a	a	DT
cord-326960-9phlylce	296	146	blinded	blind	VBN
cord-326960-9phlylce	296	147	,	,	,
cord-326960-9phlylce	296	148	randomized	randomized	JJ
cord-326960-9phlylce	296	149	,	,	,
cord-326960-9phlylce	296	150	placebo	placebo	NN
cord-326960-9phlylce	296	151	-	-	HYPH
cord-326960-9phlylce	296	152	controlled	control	VBN
cord-326960-9phlylce	296	153	trial	trial	NN
cord-326960-9phlylce	296	154	of	of	IN
cord-326960-9phlylce	296	155	adults	adult	NNS
cord-326960-9phlylce	296	156	in	in	IN
cord-326960-9phlylce	296	157	Mexico	Mexico	NNP
cord-326960-9phlylce	296	158	Development	Development	NNP
cord-326960-9phlylce	296	159	of	of	IN
cord-326960-9phlylce	296	160	influenza	influenza	NN
cord-326960-9phlylce	296	161	H7N9	H7N9	NNP
cord-326960-9phlylce	296	162	virus	virus	NN
cord-326960-9phlylce	296	163	like	like	IN
cord-326960-9phlylce	296	164	particle	particle	NN
cord-326960-9phlylce	296	165	(	(	-LRB-
cord-326960-9phlylce	296	166	VLP	VLP	NNP
cord-326960-9phlylce	296	167	)	)	-RRB-
cord-326960-9phlylce	296	168	vaccine	vaccine	NN
cord-326960-9phlylce	296	169	:	:	:
cord-326960-9phlylce	296	170	Homologous	Homologous	NNP
cord-326960-9phlylce	296	171	A	A	NNP
cord-326960-9phlylce	296	172	/	/	SYM
cord-326960-9phlylce	296	173	Anhui/1/2013	anhui/1/2013	NN
cord-326960-9phlylce	296	174	(	(	-LRB-
cord-326960-9phlylce	296	175	H7N9	H7N9	NNP
cord-326960-9phlylce	296	176	)	)	-RRB-
cord-326960-9phlylce	296	177	protection	protection	NN
cord-326960-9phlylce	296	178	and	and	CC
cord-326960-9phlylce	296	179	heterologous	heterologous	NNP
cord-326960-9phlylce	296	180	A	A	NNP
cord-326960-9phlylce	296	181	/	/	SYM
cord-326960-9phlylce	296	182	chicken	chicken	NNP
cord-326960-9phlylce	296	183	/	/	SYM
cord-326960-9phlylce	296	184	Jalisco	Jalisco	NNP
cord-326960-9phlylce	296	185	/	/	SYM
cord-326960-9phlylce	296	186	CPA1/2012	CPA1/2012	NNP
cord-326960-9phlylce	297	1	(	(	-LRB-
cord-326960-9phlylce	297	2	H7N3	H7N3	NNP
cord-326960-9phlylce	297	3	)	)	-RRB-
cord-326960-9phlylce	297	4	cross	cross	NN
cord-326960-9phlylce	297	5	-	-	NN
cord-326960-9phlylce	297	6	protection	protection	NN
cord-326960-9phlylce	297	7	in	in	IN
cord-326960-9phlylce	297	8	vaccinated	vaccinated	JJ
cord-326960-9phlylce	297	9	mice	mouse	NNS
cord-326960-9phlylce	297	10	challenged	challenge	VBN
cord-326960-9phlylce	297	11	with	with	IN
cord-326960-9phlylce	297	12	H7N9	H7N9	NNP
cord-326960-9phlylce	297	13	virus	virus	NN
cord-326960-9phlylce	297	14	Influenza	Influenza	NNP
cord-326960-9phlylce	297	15	virus	virus	NN
cord-326960-9phlylce	297	16	-	-	HYPH
cord-326960-9phlylce	297	17	like	like	JJ
cord-326960-9phlylce	297	18	particles	particle	NNS
cord-326960-9phlylce	297	19	elicit	elicit	VBP
cord-326960-9phlylce	297	20	broader	broad	JJR
cord-326960-9phlylce	297	21	immune	immune	JJ
cord-326960-9phlylce	297	22	responses	response	NNS
cord-326960-9phlylce	297	23	than	than	IN
cord-326960-9phlylce	297	24	whole	whole	JJ
cord-326960-9phlylce	297	25	virion	virion	NN
cord-326960-9phlylce	297	26	inactivated	inactivate	VBD
cord-326960-9phlylce	297	27	influenza	influenza	NN
cord-326960-9phlylce	297	28	virus	virus	NN
cord-326960-9phlylce	297	29	or	or	CC
cord-326960-9phlylce	297	30	recombinant	recombinant	JJ
cord-326960-9phlylce	297	31	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	298	1	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	298	2	-	-	HYPH
cord-326960-9phlylce	298	3	expressed	express	VBN
cord-326960-9phlylce	298	4	influenza	influenza	NN
cord-326960-9phlylce	298	5	vaccine	vaccine	NN
cord-326960-9phlylce	298	6	.	.	.
cord-326960-9phlylce	299	1	A	a	DT
cord-326960-9phlylce	299	2	novel	novel	JJ
cord-326960-9phlylce	299	3	technology	technology	NN
cord-326960-9phlylce	299	4	for	for	IN
cord-326960-9phlylce	299	5	safe	safe	JJ
cord-326960-9phlylce	299	6	and	and	CC
cord-326960-9phlylce	299	7	expeditious	expeditious	JJ
cord-326960-9phlylce	299	8	vaccine	vaccine	NN
cord-326960-9phlylce	299	9	production	production	NN
cord-326960-9phlylce	299	10	for	for	IN
cord-326960-9phlylce	299	11	human	human	JJ
cord-326960-9phlylce	299	12	use	use	NN
cord-326960-9phlylce	299	13	Influenza	Influenza	NNP
cord-326960-9phlylce	299	14	neuraminidase	neuraminidase	NN
cord-326960-9phlylce	299	15	as	as	IN
cord-326960-9phlylce	299	16	a	a	DT
cord-326960-9phlylce	299	17	vaccine	vaccine	NN
cord-326960-9phlylce	299	18	antigen	antigen	NN
cord-326960-9phlylce	299	19	Advances	advance	VBZ
cord-326960-9phlylce	299	20	in	in	IN
cord-326960-9phlylce	299	21	universal	universal	JJ
cord-326960-9phlylce	299	22	influenza	influenza	NN
cord-326960-9phlylce	299	23	virus	virus	NN
cord-326960-9phlylce	299	24	vaccine	vaccine	NN
cord-326960-9phlylce	299	25	design	design	NN
cord-326960-9phlylce	299	26	and	and	CC
cord-326960-9phlylce	299	27	antibody	antibody	NN
cord-326960-9phlylce	299	28	mediated	mediate	VBN
cord-326960-9phlylce	299	29	therapies	therapy	NNS
cord-326960-9phlylce	299	30	based	base	VBN
cord-326960-9phlylce	299	31	on	on	IN
cord-326960-9phlylce	299	32	conserved	conserved	JJ
cord-326960-9phlylce	299	33	regions	region	NNS
cord-326960-9phlylce	299	34	of	of	IN
cord-326960-9phlylce	299	35	the	the	DT
cord-326960-9phlylce	299	36	hemagglutinin	hemagglutinin	NN
cord-326960-9phlylce	299	37	Development	Development	NNP
cord-326960-9phlylce	299	38	of	of	IN
cord-326960-9phlylce	299	39	the	the	DT
cord-326960-9phlylce	299	40	vault	vault	NN
cord-326960-9phlylce	299	41	particle	particle	NN
cord-326960-9phlylce	299	42	as	as	IN
cord-326960-9phlylce	299	43	a	a	DT
cord-326960-9phlylce	299	44	platform	platform	NN
cord-326960-9phlylce	299	45	technology	technology	NN
cord-326960-9phlylce	299	46	Middle	Middle	NNP
cord-326960-9phlylce	299	47	East	East	NNP
cord-326960-9phlylce	299	48	respiratory	respiratory	JJ
cord-326960-9phlylce	299	49	syndrome	syndrome	NN
cord-326960-9phlylce	299	50	coronavirus	coronavirus	NN
cord-326960-9phlylce	299	51	:	:	:
cord-326960-9phlylce	300	1	Transmission	transmission	NN
cord-326960-9phlylce	300	2	and	and	CC
cord-326960-9phlylce	300	3	phylogenetic	phylogenetic	JJ
cord-326960-9phlylce	300	4	evolution	evolution	NN
cord-326960-9phlylce	300	5	Severe	severe	JJ
cord-326960-9phlylce	300	6	acute	acute	JJ
cord-326960-9phlylce	300	7	respiratory	respiratory	JJ
cord-326960-9phlylce	300	8	syndrome	syndrome	NN
cord-326960-9phlylce	300	9	vs.	vs.	IN
cord-326960-9phlylce	300	10	the	the	DT
cord-326960-9phlylce	300	11	Middle	Middle	NNP
cord-326960-9phlylce	300	12	East	East	NNP
cord-326960-9phlylce	300	13	respiratory	respiratory	JJ
cord-326960-9phlylce	300	14	syndrome	syndrome	NN
cord-326960-9phlylce	300	15	Porcine	porcine	JJ
cord-326960-9phlylce	300	16	epidemic	epidemic	NN
cord-326960-9phlylce	300	17	diarrhoea	diarrhoea	NN
cord-326960-9phlylce	300	18	virus	virus	NN
cord-326960-9phlylce	300	19	:	:	:
cord-326960-9phlylce	300	20	A	a	DT
cord-326960-9phlylce	300	21	comprehensive	comprehensive	JJ
cord-326960-9phlylce	300	22	review	review	NN
cord-326960-9phlylce	300	23	of	of	IN
cord-326960-9phlylce	300	24	molecular	molecular	JJ
cord-326960-9phlylce	300	25	epidemiology	epidemiology	NN
cord-326960-9phlylce	300	26	,	,	,
cord-326960-9phlylce	300	27	diagnosis	diagnosis	NN
cord-326960-9phlylce	300	28	,	,	,
cord-326960-9phlylce	300	29	and	and	CC
cord-326960-9phlylce	300	30	vaccines	vaccine	NNS
cord-326960-9phlylce	300	31	The	the	DT
cord-326960-9phlylce	300	32	SARS	SARS	NNP
cord-326960-9phlylce	300	33	-	-	HYPH
cord-326960-9phlylce	300	34	CoV	CoV	NNP
cord-326960-9phlylce	300	35	S	S	NNP
cord-326960-9phlylce	300	36	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	300	37	Current	current	JJ
cord-326960-9phlylce	300	38	advancements	advancement	NNS
cord-326960-9phlylce	300	39	and	and	CC
cord-326960-9phlylce	300	40	potential	potential	JJ
cord-326960-9phlylce	300	41	strategies	strategy	NNS
cord-326960-9phlylce	300	42	in	in	IN
cord-326960-9phlylce	300	43	the	the	DT
cord-326960-9phlylce	300	44	development	development	NN
cord-326960-9phlylce	300	45	of	of	IN
cord-326960-9phlylce	300	46	MERS	MERS	NNP
cord-326960-9phlylce	300	47	-	-	HYPH
cord-326960-9phlylce	300	48	CoV	CoV	NNP
cord-326960-9phlylce	300	49	vaccines	vaccine	NNS
cord-326960-9phlylce	300	50	Drug	Drug	NNP
cord-326960-9phlylce	300	51	targets	target	NNS
cord-326960-9phlylce	300	52	for	for	IN
cord-326960-9phlylce	300	53	rational	rational	JJ
cord-326960-9phlylce	300	54	design	design	NN
cord-326960-9phlylce	300	55	against	against	IN
cord-326960-9phlylce	300	56	emerging	emerge	VBG
cord-326960-9phlylce	300	57	coronaviruses	coronaviruse	NNS
cord-326960-9phlylce	301	1	Baculovirus	Baculovirus	NNP
cord-326960-9phlylce	301	2	surface	surface	NN
cord-326960-9phlylce	301	3	display	display	NN
cord-326960-9phlylce	301	4	of	of	IN
cord-326960-9phlylce	301	5	SARS	SARS	NNP
cord-326960-9phlylce	301	6	coronavirus	coronavirus	NN
cord-326960-9phlylce	301	7	(	(	-LRB-
cord-326960-9phlylce	301	8	SARS	SARS	NNP
cord-326960-9phlylce	301	9	-	-	HYPH
cord-326960-9phlylce	301	10	CoV	CoV	NNP
cord-326960-9phlylce	301	11	)	)	-RRB-
cord-326960-9phlylce	301	12	spike	spike	NN
cord-326960-9phlylce	301	13	protein	protein	NN
cord-326960-9phlylce	301	14	and	and	CC
cord-326960-9phlylce	301	15	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	301	16	of	of	IN
cord-326960-9phlylce	301	17	the	the	DT
cord-326960-9phlylce	301	18	displayed	display	VBN
cord-326960-9phlylce	301	19	protein	protein	NN
cord-326960-9phlylce	301	20	in	in	IN
cord-326960-9phlylce	301	21	mice	mouse	NNS
cord-326960-9phlylce	301	22	models	model	NNS
cord-326960-9phlylce	301	23	Antigenic	antigenic	JJ
cord-326960-9phlylce	301	24	and	and	CC
cord-326960-9phlylce	301	25	immunogenic	immunogenic	JJ
cord-326960-9phlylce	301	26	characterization	characterization	NN
cord-326960-9phlylce	301	27	of	of	IN
cord-326960-9phlylce	301	28	recombinant	recombinant	JJ
cord-326960-9phlylce	301	29	baculovirusexpressed	baculovirusexpresse	VBN
cord-326960-9phlylce	301	30	severe	severe	JJ
cord-326960-9phlylce	301	31	acute	acute	JJ
cord-326960-9phlylce	301	32	respiratory	respiratory	JJ
cord-326960-9phlylce	301	33	syndrome	syndrome	NN
cord-326960-9phlylce	301	34	coronavirus	coronavirus	NN
cord-326960-9phlylce	301	35	spike	spike	NN
cord-326960-9phlylce	301	36	protein	protein	NN
cord-326960-9phlylce	301	37	:	:	:
cord-326960-9phlylce	302	1	Implication	implication	NN
cord-326960-9phlylce	302	2	for	for	IN
cord-326960-9phlylce	302	3	vaccine	vaccine	NN
cord-326960-9phlylce	302	4	design	design	NN
cord-326960-9phlylce	302	5	Immune	immune	JJ
cord-326960-9phlylce	302	6	responses	response	NNS
cord-326960-9phlylce	302	7	against	against	IN
cord-326960-9phlylce	302	8	severe	severe	JJ
cord-326960-9phlylce	302	9	acute	acute	JJ
cord-326960-9phlylce	302	10	respiratory	respiratory	JJ
cord-326960-9phlylce	302	11	syndrome	syndrome	NN
cord-326960-9phlylce	302	12	coronavirus	coronavirus	NN
cord-326960-9phlylce	302	13	induced	induce	VBN
cord-326960-9phlylce	302	14	by	by	IN
cord-326960-9phlylce	302	15	viruslike	viruslike	JJ
cord-326960-9phlylce	302	16	particles	particle	NNS
cord-326960-9phlylce	302	17	in	in	IN
cord-326960-9phlylce	302	18	mice	mouse	NNS
cord-326960-9phlylce	302	19	Virus	virus	NN
cord-326960-9phlylce	302	20	-	-	HYPH
cord-326960-9phlylce	302	21	like	like	JJ
cord-326960-9phlylce	302	22	particles	particle	NNS
cord-326960-9phlylce	302	23	of	of	IN
cord-326960-9phlylce	302	24	SARSlike	sarslike	JJ
cord-326960-9phlylce	302	25	coronavirus	coronavirus	NN
cord-326960-9phlylce	302	26	formed	form	VBN
cord-326960-9phlylce	302	27	by	by	IN
cord-326960-9phlylce	302	28	membrane	membrane	NN
cord-326960-9phlylce	302	29	proteins	protein	NNS
cord-326960-9phlylce	302	30	from	from	IN
cord-326960-9phlylce	302	31	different	different	JJ
cord-326960-9phlylce	302	32	origins	origin	NNS
cord-326960-9phlylce	302	33	demonstrate	demonstrate	VBP
cord-326960-9phlylce	302	34	stimulating	stimulate	VBG
cord-326960-9phlylce	302	35	activity	activity	NN
cord-326960-9phlylce	302	36	in	in	IN
cord-326960-9phlylce	302	37	human	human	JJ
cord-326960-9phlylce	302	38	dendritic	dendritic	JJ
cord-326960-9phlylce	302	39	cells	cell	NNS
cord-326960-9phlylce	302	40	Vaccination	vaccination	NN
cord-326960-9phlylce	302	41	of	of	IN
cord-326960-9phlylce	302	42	mice	mouse	NNS
cord-326960-9phlylce	302	43	with	with	IN
cord-326960-9phlylce	302	44	recombinant	recombinant	JJ
cord-326960-9phlylce	302	45	baculovirus	baculovirus	NN
cord-326960-9phlylce	302	46	expressing	express	VBG
cord-326960-9phlylce	302	47	spike	spike	NN
cord-326960-9phlylce	302	48	or	or	CC
cord-326960-9phlylce	302	49	nucleocapsid	nucleocapsid	NN
cord-326960-9phlylce	302	50	protein	protein	NN
cord-326960-9phlylce	302	51	of	of	IN
cord-326960-9phlylce	302	52	SARS	SARS	NNP
cord-326960-9phlylce	302	53	-	-	HYPH
cord-326960-9phlylce	302	54	like	like	JJ
cord-326960-9phlylce	302	55	coronavirus	coronavirus	NN
cord-326960-9phlylce	302	56	generates	generate	VBZ
cord-326960-9phlylce	302	57	humoral	humoral	JJ
cord-326960-9phlylce	302	58	and	and	CC
cord-326960-9phlylce	302	59	cellular	cellular	JJ
cord-326960-9phlylce	302	60	immune	immune	JJ
cord-326960-9phlylce	302	61	responses	response	NNS
cord-326960-9phlylce	302	62	Effect	effect	NN
cord-326960-9phlylce	302	63	of	of	IN
cord-326960-9phlylce	302	64	mucosal	mucosal	JJ
cord-326960-9phlylce	302	65	and	and	CC
cord-326960-9phlylce	302	66	systemic	systemic	JJ
cord-326960-9phlylce	302	67	immunization	immunization	NN
cord-326960-9phlylce	302	68	with	with	IN
cord-326960-9phlylce	302	69	virus	virus	NN
cord-326960-9phlylce	302	70	-	-	HYPH
cord-326960-9phlylce	302	71	like	like	JJ
cord-326960-9phlylce	302	72	particles	particle	NNS
cord-326960-9phlylce	302	73	of	of	IN
cord-326960-9phlylce	302	74	severe	severe	JJ
cord-326960-9phlylce	302	75	acute	acute	JJ
cord-326960-9phlylce	302	76	respiratory	respiratory	JJ
cord-326960-9phlylce	302	77	syndrome	syndrome	NN
cord-326960-9phlylce	302	78	coronavirus	coronavirus	NN
cord-326960-9phlylce	302	79	in	in	IN
cord-326960-9phlylce	302	80	mice	mouse	NNS
cord-326960-9phlylce	302	81	Chimeric	chimeric	JJ
cord-326960-9phlylce	302	82	severe	severe	JJ
cord-326960-9phlylce	302	83	acute	acute	JJ
cord-326960-9phlylce	302	84	respiratory	respiratory	JJ
cord-326960-9phlylce	302	85	syndrome	syndrome	NN
cord-326960-9phlylce	302	86	coronavirus	coronavirus	NN
cord-326960-9phlylce	302	87	(	(	-LRB-
cord-326960-9phlylce	302	88	SARS	SARS	NNP
cord-326960-9phlylce	302	89	-	-	HYPH
cord-326960-9phlylce	302	90	CoV	CoV	NNP
cord-326960-9phlylce	302	91	)	)	-RRB-
cord-326960-9phlylce	302	92	S	S	NNP
cord-326960-9phlylce	302	93	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	302	94	and	and	CC
cord-326960-9phlylce	302	95	influenza	influenza	NN
cord-326960-9phlylce	302	96	matrix	matrix	NN
cord-326960-9phlylce	302	97	1	1	CD
cord-326960-9phlylce	302	98	efficiently	efficiently	RB
cord-326960-9phlylce	302	99	form	form	VBP
cord-326960-9phlylce	302	100	virus	virus	NN
cord-326960-9phlylce	302	101	-	-	HYPH
cord-326960-9phlylce	302	102	like	like	JJ
cord-326960-9phlylce	302	103	particles	particle	NNS
cord-326960-9phlylce	302	104	(	(	-LRB-
cord-326960-9phlylce	302	105	VLPs	vlp	NNS
cord-326960-9phlylce	302	106	)	)	-RRB-
cord-326960-9phlylce	302	107	that	that	WDT
cord-326960-9phlylce	302	108	protect	protect	VBP
cord-326960-9phlylce	302	109	mice	mouse	NNS
cord-326960-9phlylce	302	110	against	against	IN
cord-326960-9phlylce	302	111	challenge	challenge	NN
cord-326960-9phlylce	302	112	with	with	IN
cord-326960-9phlylce	302	113	SARS	SARS	NNP
cord-326960-9phlylce	302	114	-	-	HYPH
cord-326960-9phlylce	302	115	CoV	CoV	NNP
cord-326960-9phlylce	302	116	Assembly	Assembly	NNP
cord-326960-9phlylce	302	117	and	and	CC
cord-326960-9phlylce	302	118	immunogenicity	immunogenicity	NN
cord-326960-9phlylce	302	119	of	of	IN
cord-326960-9phlylce	302	120	coronavirus	coronavirus	NN
cord-326960-9phlylce	302	121	-	-	HYPH
cord-326960-9phlylce	302	122	like	like	JJ
cord-326960-9phlylce	302	123	particles	particle	NNS
cord-326960-9phlylce	302	124	carrying	carry	VBG
cord-326960-9phlylce	302	125	infectious	infectious	JJ
cord-326960-9phlylce	302	126	bronchitis	bronchitis	NN
cord-326960-9phlylce	302	127	virus	virus	NN
cord-326960-9phlylce	302	128	M	M	NNP
cord-326960-9phlylce	302	129	and	and	CC
cord-326960-9phlylce	302	130	S	S	NNP
cord-326960-9phlylce	302	131	proteins	protein	NNS
cord-326960-9phlylce	303	1	Purified	purify	VBN
cord-326960-9phlylce	303	2	coronavirus	coronavirus	NN
cord-326960-9phlylce	303	3	spike	spike	NN
cord-326960-9phlylce	303	4	protein	protein	NN
cord-326960-9phlylce	303	5	nanoparticles	nanoparticle	NNS
cord-326960-9phlylce	303	6	induce	induce	VBP
cord-326960-9phlylce	303	7	coronavirus	coronavirus	NN
cord-326960-9phlylce	303	8	neutralizing	neutralize	VBG
cord-326960-9phlylce	303	9	antibodies	antibody	NNS
cord-326960-9phlylce	303	10	in	in	IN
cord-326960-9phlylce	303	11	mice	mouse	NNS
cord-326960-9phlylce	303	12	Chikungunya	chikungunya	NN
cord-326960-9phlylce	303	13	at	at	IN
cord-326960-9phlylce	303	14	the	the	DT
cord-326960-9phlylce	303	15	door	door	NN
cord-326960-9phlylce	303	16	-Deja	-Deja	.
cord-326960-9phlylce	304	1	vu	vu	NN
cord-326960-9phlylce	304	2	all	all	RB
cord-326960-9phlylce	304	3	over	over	RB
cord-326960-9phlylce	304	4	again	again	RB
cord-326960-9phlylce	304	5	?	?	.
cord-326960-9phlylce	305	1	Effective	effective	JJ
cord-326960-9phlylce	305	2	chikungunya	chikungunya	NN
cord-326960-9phlylce	305	3	virus	virus	NN
cord-326960-9phlylce	305	4	-	-	:
cord-326960-9phlylce	305	5	like	like	JJ
cord-326960-9phlylce	305	6	particle	particle	NN
cord-326960-9phlylce	305	7	vaccine	vaccine	NN
cord-326960-9phlylce	305	8	produced	produce	VBN
cord-326960-9phlylce	305	9	in	in	IN
cord-326960-9phlylce	305	10	insect	insect	NN
cord-326960-9phlylce	305	11	cells	cell	NNS
cord-326960-9phlylce	305	12	Chikungunya	chikungunya	NN
cord-326960-9phlylce	305	13	virus	virus	NN
cord-326960-9phlylce	305	14	-	-	:
cord-326960-9phlylce	305	15	like	like	JJ
cord-326960-9phlylce	305	16	particles	particle	NNS
cord-326960-9phlylce	305	17	are	be	VBP
cord-326960-9phlylce	305	18	more	more	RBR
cord-326960-9phlylce	305	19	immunogenic	immunogenic	JJ
cord-326960-9phlylce	305	20	in	in	IN
cord-326960-9phlylce	305	21	a	a	DT
cord-326960-9phlylce	305	22	lethal	lethal	JJ
cord-326960-9phlylce	305	23	AG129	AG129	NNP
cord-326960-9phlylce	305	24	mouse	mouse	NN
cord-326960-9phlylce	305	25	model	model	NN
cord-326960-9phlylce	305	26	compared	compare	VBN
cord-326960-9phlylce	305	27	to	to	IN
cord-326960-9phlylce	305	28	glycoprotein	glycoprotein	NN
cord-326960-9phlylce	305	29	E1	e1	NN
cord-326960-9phlylce	305	30	or	or	CC
cord-326960-9phlylce	305	31	E2	E2	NNP
cord-326960-9phlylce	305	32	subunits	subunit	NNS
cord-326960-9phlylce	306	1	Enhanced	enhanced	JJ
cord-326960-9phlylce	306	2	production	production	NN
cord-326960-9phlylce	306	3	of	of	IN
cord-326960-9phlylce	306	4	Chikungunya	Chikungunya	NNP
cord-326960-9phlylce	306	5	virus	virus	NN
cord-326960-9phlylce	306	6	-	-	:
cord-326960-9phlylce	306	7	like	like	JJ
cord-326960-9phlylce	306	8	particles	particle	NNS
cord-326960-9phlylce	306	9	using	use	VBG
cord-326960-9phlylce	306	10	a	a	DT
cord-326960-9phlylce	306	11	high	high	JJ
cord-326960-9phlylce	306	12	-	-	HYPH
cord-326960-9phlylce	306	13	pH	ph	NN
cord-326960-9phlylce	306	14	adapted	adapt	VBN
cord-326960-9phlylce	306	15	Spodoptera	Spodoptera	NNP
cord-326960-9phlylce	306	16	frugiperda	frugiperda	JJ
cord-326960-9phlylce	306	17	insect	insect	NN
cord-326960-9phlylce	306	18	cell	cell	NN
cord-326960-9phlylce	306	19	line	line	NN
cord-326960-9phlylce	306	20	Estimating	estimate	VBG
cord-326960-9phlylce	306	21	the	the	DT
cord-326960-9phlylce	306	22	Ebola	Ebola	NNP
cord-326960-9phlylce	306	23	epidemic	epidemic	NN
cord-326960-9phlylce	306	24	Antibodies	antibody	NNS
cord-326960-9phlylce	306	25	are	be	VBP
cord-326960-9phlylce	306	26	necessary	necessary	JJ
cord-326960-9phlylce	306	27	for	for	IN
cord-326960-9phlylce	306	28	rVSV	rVSV	NNP
cord-326960-9phlylce	306	29	/	/	SYM
cord-326960-9phlylce	306	30	ZEBOV	ZEBOV	NNP
cord-326960-9phlylce	306	31	-	-	HYPH
cord-326960-9phlylce	306	32	GP	gp	NN
cord-326960-9phlylce	306	33	-	-	HYPH
cord-326960-9phlylce	306	34	mediated	mediate	VBN
cord-326960-9phlylce	306	35	protection	protection	NN
cord-326960-9phlylce	306	36	against	against	IN
cord-326960-9phlylce	306	37	lethal	lethal	JJ
cord-326960-9phlylce	306	38	Ebola	Ebola	NNP
cord-326960-9phlylce	306	39	virus	virus	NN
cord-326960-9phlylce	306	40	challenge	challenge	NN
cord-326960-9phlylce	306	41	in	in	IN
cord-326960-9phlylce	306	42	nonhuman	nonhuman	NN
cord-326960-9phlylce	306	43	primates	primate	NNS
cord-326960-9phlylce	306	44	Easy	easy	JJ
cord-326960-9phlylce	306	45	expression	expression	NN
cord-326960-9phlylce	306	46	of	of	IN
cord-326960-9phlylce	306	47	the	the	DT
cord-326960-9phlylce	306	48	C	C	NNP
cord-326960-9phlylce	306	49	-	-	HYPH
cord-326960-9phlylce	306	50	terminal	terminal	JJ
cord-326960-9phlylce	306	51	heavy	heavy	JJ
cord-326960-9phlylce	306	52	chain	chain	NN
cord-326960-9phlylce	306	53	domain	domain	NN
cord-326960-9phlylce	306	54	of	of	IN
cord-326960-9phlylce	306	55	botulinum	botulinum	NN
cord-326960-9phlylce	306	56	neurotoxin	neurotoxin	NN
cord-326960-9phlylce	306	57	serotype	serotype	NN
cord-326960-9phlylce	306	58	A	a	NN
cord-326960-9phlylce	306	59	as	as	IN
cord-326960-9phlylce	306	60	a	a	DT
cord-326960-9phlylce	306	61	vaccine	vaccine	NN
cord-326960-9phlylce	306	62	candidate	candidate	NN
cord-326960-9phlylce	306	63	using	use	VBG
cord-326960-9phlylce	306	64	a	a	DT
cord-326960-9phlylce	306	65	bi	bi	JJ
cord-326960-9phlylce	306	66	-	-	JJ
cord-326960-9phlylce	306	67	cistronic	cistronic	JJ
cord-326960-9phlylce	306	68	baculovirus	baculovirus	NN
cord-326960-9phlylce	306	69	system	system	NN
cord-326960-9phlylce	306	70	Rapid	Rapid	NNP
cord-326960-9phlylce	306	71	immune	immune	JJ
cord-326960-9phlylce	306	72	responses	response	NNS
cord-326960-9phlylce	306	73	to	to	IN
cord-326960-9phlylce	306	74	a	a	DT
cord-326960-9phlylce	306	75	botulinum	botulinum	NN
cord-326960-9phlylce	306	76	neurotoxin	neurotoxin	NN
cord-326960-9phlylce	306	77	Hc	Hc	NNP
cord-326960-9phlylce	306	78	subunit	subunit	NN
cord-326960-9phlylce	306	79	vaccine	vaccine	NN
cord-326960-9phlylce	306	80	through	through	IN
cord-326960-9phlylce	306	81	in	in	IN
cord-326960-9phlylce	306	82	vivo	vivo	NN
cord-326960-9phlylce	306	83	targeting	target	VBG
cord-326960-9phlylce	306	84	to	to	IN
cord-326960-9phlylce	306	85	antigen	antigen	NN
cord-326960-9phlylce	306	86	-	-	HYPH
cord-326960-9phlylce	306	87	presenting	present	VBG
cord-326960-9phlylce	306	88	cells	cell	NNS
cord-326960-9phlylce	306	89	Development	Development	NNP
cord-326960-9phlylce	306	90	of	of	IN
cord-326960-9phlylce	306	91	a	a	DT
cord-326960-9phlylce	306	92	recombinant	recombinant	JJ
cord-326960-9phlylce	306	93	toxin	toxin	NN
cord-326960-9phlylce	306	94	fragment	fragment	NN
cord-326960-9phlylce	306	95	vaccine	vaccine	NN
cord-326960-9phlylce	306	96	for	for	IN
cord-326960-9phlylce	306	97	Clostridium	clostridium	NN
cord-326960-9phlylce	306	98	difficile	difficile	NN
cord-326960-9phlylce	306	99	infection	infection	NN
cord-326960-9phlylce	306	100	Recombinant	recombinant	JJ
cord-326960-9phlylce	306	101	antigens	antigen	NNS
cord-326960-9phlylce	306	102	based	base	VBN
cord-326960-9phlylce	306	103	on	on	IN
cord-326960-9phlylce	306	104	toxins	toxin	NNS
cord-326960-9phlylce	306	105	A	A	NNP
cord-326960-9phlylce	306	106	and	and	CC
cord-326960-9phlylce	306	107	B	b	NN
cord-326960-9phlylce	306	108	of	of	IN
cord-326960-9phlylce	306	109	Clostridium	clostridium	NN
cord-326960-9phlylce	306	110	difficile	difficile	FW
cord-326960-9phlylce	306	111	that	that	WDT
cord-326960-9phlylce	306	112	evoke	evoke	VBP
cord-326960-9phlylce	306	113	a	a	DT
cord-326960-9phlylce	306	114	potent	potent	JJ
cord-326960-9phlylce	306	115	toxin	toxin	NN
cord-326960-9phlylce	306	116	-	-	HYPH
cord-326960-9phlylce	306	117	neutralising	neutralise	VBG
cord-326960-9phlylce	306	118	immune	immune	JJ
cord-326960-9phlylce	306	119	response	response	NN
cord-326960-9phlylce	306	120	Reingard	Reingard	NNP
cord-326960-9phlylce	306	121	Grabherr	Grabherr	NNP
cord-326960-9phlylce	306	122	 	 	_SP