id	sid	tid	token	lemma	pos
cord-333722-ndth5zne	1	1	key	key	NN
cord-333722-ndth5zne	1	2	:	:	:
cord-333722-ndth5zne	2	1	cord-333722-ndth5zne	cord-333722-ndth5zne	NNP
cord-333722-ndth5zne	2	2	authors	author	NNS
cord-333722-ndth5zne	2	3	:	:	:
cord-333722-ndth5zne	2	4	Liu	Liu	NNP
cord-333722-ndth5zne	2	5	,	,	,
cord-333722-ndth5zne	2	6	Qiang	Qiang	NNP
cord-333722-ndth5zne	2	7	;	;	:
cord-333722-ndth5zne	2	8	Zhou	Zhou	NNP
cord-333722-ndth5zne	2	9	,	,	,
cord-333722-ndth5zne	2	10	Yuan	Yuan	NNP
cord-333722-ndth5zne	2	11	-	-	HYPH
cord-333722-ndth5zne	2	12	hong	hong	NNP
cord-333722-ndth5zne	2	13	;	;	:
cord-333722-ndth5zne	3	1	Yang	Yang	NNP
cord-333722-ndth5zne	3	2	,	,	,
cord-333722-ndth5zne	3	3	Zhan	Zhan	NNP
cord-333722-ndth5zne	3	4	-	-	HYPH
cord-333722-ndth5zne	3	5	qiu	qiu	NNP
cord-333722-ndth5zne	3	6	title	title	NN
cord-333722-ndth5zne	3	7	:	:	:
cord-333722-ndth5zne	3	8	The	the	DT
cord-333722-ndth5zne	3	9	cytokine	cytokine	NN
cord-333722-ndth5zne	3	10	storm	storm	NN
cord-333722-ndth5zne	3	11	of	of	IN
cord-333722-ndth5zne	3	12	severe	severe	JJ
cord-333722-ndth5zne	3	13	influenza	influenza	NN
cord-333722-ndth5zne	3	14	and	and	CC
cord-333722-ndth5zne	3	15	development	development	NN
cord-333722-ndth5zne	3	16	of	of	IN
cord-333722-ndth5zne	3	17	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	3	18	therapy	therapy	NN
cord-333722-ndth5zne	3	19	date	date	NN
cord-333722-ndth5zne	3	20	:	:	:
cord-333722-ndth5zne	3	21	2015	2015	CD
cord-333722-ndth5zne	3	22	-	-	HYPH
cord-333722-ndth5zne	3	23	07	07	CD
cord-333722-ndth5zne	3	24	-	-	HYPH
cord-333722-ndth5zne	3	25	20	20	CD
cord-333722-ndth5zne	3	26	journal	journal	NN
cord-333722-ndth5zne	3	27	:	:	:
cord-333722-ndth5zne	3	28	Cellular	Cellular	NNP
cord-333722-ndth5zne	3	29	&	&	CC
cord-333722-ndth5zne	3	30	Molecular	Molecular	NNP
cord-333722-ndth5zne	3	31	Immunology	Immunology	NNP
cord-333722-ndth5zne	3	32	DOI	DOI	NNP
cord-333722-ndth5zne	3	33	:	:	:
cord-333722-ndth5zne	4	1	10.1038	10.1038	CD
cord-333722-ndth5zne	4	2	/	/	SYM
cord-333722-ndth5zne	4	3	cmi.2015.74	cmi.2015.74	CD
cord-333722-ndth5zne	4	4	sha	sha	NNP
cord-333722-ndth5zne	4	5	:	:	:
cord-333722-ndth5zne	5	1	9a2861a88c29eff57124d757c0a24dd6bee7b462	9a2861a88c29eff57124d757c0a24dd6bee7b462	CD
cord-333722-ndth5zne	5	2	doc_id	doc_id	CD
cord-333722-ndth5zne	5	3	:	:	:
cord-333722-ndth5zne	5	4	333722	333722	CD
cord-333722-ndth5zne	5	5	cord_uid	cord_uid	NNS
cord-333722-ndth5zne	5	6	:	:	:
cord-333722-ndth5zne	5	7	ndth5zne	ndth5zne	JJ
cord-333722-ndth5zne	6	1	Severe	severe	JJ
cord-333722-ndth5zne	6	2	influenza	influenza	NN
cord-333722-ndth5zne	6	3	remains	remain	VBZ
cord-333722-ndth5zne	6	4	unusual	unusual	JJ
cord-333722-ndth5zne	6	5	in	in	IN
cord-333722-ndth5zne	6	6	its	-PRON-	PRP$
cord-333722-ndth5zne	6	7	virulence	virulence	NN
cord-333722-ndth5zne	6	8	for	for	IN
cord-333722-ndth5zne	6	9	humans	human	NNS
cord-333722-ndth5zne	6	10	.	.	.
cord-333722-ndth5zne	7	1	Complications	complication	NNS
cord-333722-ndth5zne	7	2	or	or	CC
cord-333722-ndth5zne	7	3	ultimately	ultimately	RB
cord-333722-ndth5zne	7	4	death	death	NN
cord-333722-ndth5zne	7	5	arising	arise	VBG
cord-333722-ndth5zne	7	6	from	from	IN
cord-333722-ndth5zne	7	7	these	these	DT
cord-333722-ndth5zne	7	8	infections	infection	NNS
cord-333722-ndth5zne	7	9	are	be	VBP
cord-333722-ndth5zne	7	10	often	often	RB
cord-333722-ndth5zne	7	11	associated	associate	VBN
cord-333722-ndth5zne	7	12	with	with	IN
cord-333722-ndth5zne	7	13	hyperinduction	hyperinduction	NN
cord-333722-ndth5zne	7	14	of	of	IN
cord-333722-ndth5zne	7	15	proinflammatory	proinflammatory	JJ
cord-333722-ndth5zne	7	16	cytokine	cytokine	NN
cord-333722-ndth5zne	7	17	production	production	NN
cord-333722-ndth5zne	7	18	,	,	,
cord-333722-ndth5zne	7	19	which	which	WDT
cord-333722-ndth5zne	7	20	is	be	VBZ
cord-333722-ndth5zne	7	21	also	also	RB
cord-333722-ndth5zne	7	22	known	know	VBN
cord-333722-ndth5zne	7	23	as	as	IN
cord-333722-ndth5zne	7	24	‘	'	``
cord-333722-ndth5zne	7	25	cytokine	cytokine	NN
cord-333722-ndth5zne	7	26	storm	storm	NN
cord-333722-ndth5zne	7	27	'	'	''
cord-333722-ndth5zne	7	28	.	.	.
cord-333722-ndth5zne	8	1	For	for	IN
cord-333722-ndth5zne	8	2	this	this	DT
cord-333722-ndth5zne	8	3	disease	disease	NN
cord-333722-ndth5zne	8	4	,	,	,
cord-333722-ndth5zne	8	5	it	-PRON-	PRP
cord-333722-ndth5zne	8	6	has	have	VBZ
cord-333722-ndth5zne	8	7	been	be	VBN
cord-333722-ndth5zne	8	8	proposed	propose	VBN
cord-333722-ndth5zne	8	9	that	that	IN
cord-333722-ndth5zne	8	10	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	8	11	therapy	therapy	NN
cord-333722-ndth5zne	8	12	may	may	MD
cord-333722-ndth5zne	8	13	improve	improve	VB
cord-333722-ndth5zne	8	14	the	the	DT
cord-333722-ndth5zne	8	15	outcome	outcome	NN
cord-333722-ndth5zne	8	16	,	,	,
cord-333722-ndth5zne	8	17	with	with	IN
cord-333722-ndth5zne	8	18	or	or	CC
cord-333722-ndth5zne	8	19	without	without	IN
cord-333722-ndth5zne	8	20	the	the	DT
cord-333722-ndth5zne	8	21	combination	combination	NN
cord-333722-ndth5zne	8	22	of	of	IN
cord-333722-ndth5zne	8	23	antiviral	antiviral	JJ
cord-333722-ndth5zne	8	24	agents	agent	NNS
cord-333722-ndth5zne	8	25	.	.	.
cord-333722-ndth5zne	9	1	Here	here	RB
cord-333722-ndth5zne	9	2	,	,	,
cord-333722-ndth5zne	9	3	we	-PRON-	PRP
cord-333722-ndth5zne	9	4	review	review	VBP
cord-333722-ndth5zne	9	5	the	the	DT
cord-333722-ndth5zne	9	6	current	current	JJ
cord-333722-ndth5zne	9	7	literature	literature	NN
cord-333722-ndth5zne	9	8	on	on	IN
cord-333722-ndth5zne	9	9	how	how	WRB
cord-333722-ndth5zne	9	10	various	various	JJ
cord-333722-ndth5zne	9	11	effectors	effector	NNS
cord-333722-ndth5zne	9	12	of	of	IN
cord-333722-ndth5zne	9	13	the	the	DT
cord-333722-ndth5zne	9	14	immune	immune	JJ
cord-333722-ndth5zne	9	15	system	system	NN
cord-333722-ndth5zne	9	16	initiate	initiate	VBP
cord-333722-ndth5zne	9	17	the	the	DT
cord-333722-ndth5zne	9	18	cytokine	cytokine	NN
cord-333722-ndth5zne	9	19	storm	storm	NN
cord-333722-ndth5zne	9	20	and	and	CC
cord-333722-ndth5zne	9	21	exacerbate	exacerbate	VB
cord-333722-ndth5zne	9	22	pathological	pathological	JJ
cord-333722-ndth5zne	9	23	damage	damage	NN
cord-333722-ndth5zne	9	24	in	in	IN
cord-333722-ndth5zne	9	25	hosts	host	NNS
cord-333722-ndth5zne	9	26	.	.	.
cord-333722-ndth5zne	10	1	We	-PRON-	PRP
cord-333722-ndth5zne	10	2	also	also	RB
cord-333722-ndth5zne	10	3	review	review	VBP
cord-333722-ndth5zne	10	4	some	some	DT
cord-333722-ndth5zne	10	5	of	of	IN
cord-333722-ndth5zne	10	6	the	the	DT
cord-333722-ndth5zne	10	7	current	current	JJ
cord-333722-ndth5zne	10	8	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	10	9	strategies	strategy	NNS
cord-333722-ndth5zne	10	10	for	for	IN
cord-333722-ndth5zne	10	11	the	the	DT
cord-333722-ndth5zne	10	12	treatment	treatment	NN
cord-333722-ndth5zne	10	13	of	of	IN
cord-333722-ndth5zne	10	14	cytokine	cytokine	JJ
cord-333722-ndth5zne	10	15	storms	storm	NNS
cord-333722-ndth5zne	10	16	in	in	IN
cord-333722-ndth5zne	10	17	severe	severe	JJ
cord-333722-ndth5zne	10	18	influenza	influenza	NN
cord-333722-ndth5zne	10	19	,	,	,
cord-333722-ndth5zne	10	20	including	include	VBG
cord-333722-ndth5zne	10	21	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	10	22	,	,	,
cord-333722-ndth5zne	10	23	peroxisome	peroxisome	NN
cord-333722-ndth5zne	10	24	proliferator	proliferator	NN
cord-333722-ndth5zne	10	25	-	-	HYPH
cord-333722-ndth5zne	10	26	activated	activate	VBN
cord-333722-ndth5zne	10	27	receptor	receptor	NN
cord-333722-ndth5zne	10	28	agonists	agonist	NNS
cord-333722-ndth5zne	10	29	,	,	,
cord-333722-ndth5zne	10	30	sphingosine-1-phosphate	sphingosine-1-phosphate	NNP
cord-333722-ndth5zne	10	31	receptor	receptor	NN
cord-333722-ndth5zne	10	32	1	1	CD
cord-333722-ndth5zne	10	33	agonists	agonist	NNS
cord-333722-ndth5zne	10	34	,	,	,
cord-333722-ndth5zne	10	35	cyclooxygenase-2	cyclooxygenase-2	NNP
cord-333722-ndth5zne	10	36	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	10	37	,	,	,
cord-333722-ndth5zne	10	38	antioxidants	antioxidant	NNS
cord-333722-ndth5zne	10	39	,	,	,
cord-333722-ndth5zne	10	40	anti	anti	JJ
cord-333722-ndth5zne	10	41	-	-	JJ
cord-333722-ndth5zne	10	42	tumour	tumour	JJ
cord-333722-ndth5zne	10	43	-	-	HYPH
cord-333722-ndth5zne	10	44	necrosis	necrosis	NN
cord-333722-ndth5zne	10	45	factor	factor	NN
cord-333722-ndth5zne	10	46	therapy	therapy	NN
cord-333722-ndth5zne	10	47	,	,	,
cord-333722-ndth5zne	10	48	intravenous	intravenous	JJ
cord-333722-ndth5zne	10	49	immunoglobulin	immunoglobulin	NN
cord-333722-ndth5zne	10	50	therapy	therapy	NN
cord-333722-ndth5zne	10	51	,	,	,
cord-333722-ndth5zne	10	52	statins	statin	NNS
cord-333722-ndth5zne	10	53	,	,	,
cord-333722-ndth5zne	10	54	arbidol	arbidol	NN
cord-333722-ndth5zne	10	55	,	,	,
cord-333722-ndth5zne	10	56	herbs	herb	NNS
cord-333722-ndth5zne	10	57	,	,	,
cord-333722-ndth5zne	10	58	and	and	CC
cord-333722-ndth5zne	10	59	other	other	JJ
cord-333722-ndth5zne	10	60	potential	potential	JJ
cord-333722-ndth5zne	10	61	therapeutic	therapeutic	JJ
cord-333722-ndth5zne	10	62	strategies	strategy	NNS
cord-333722-ndth5zne	10	63	.	.	.
cord-333722-ndth5zne	11	1	Newly	newly	RB
cord-333722-ndth5zne	11	2	emerging	emerge	VBG
cord-333722-ndth5zne	11	3	and	and	CC
cord-333722-ndth5zne	11	4	re	re	JJ
cord-333722-ndth5zne	11	5	-	-	JJ
cord-333722-ndth5zne	11	6	emerging	emerge	VBG
cord-333722-ndth5zne	11	7	viral	viral	JJ
cord-333722-ndth5zne	11	8	threats	threat	NNS
cord-333722-ndth5zne	11	9	have	have	VBP
cord-333722-ndth5zne	11	10	continued	continue	VBN
cord-333722-ndth5zne	11	11	to	to	TO
cord-333722-ndth5zne	11	12	challenge	challenge	VB
cord-333722-ndth5zne	11	13	medical	medical	JJ
cord-333722-ndth5zne	11	14	and	and	CC
cord-333722-ndth5zne	11	15	public	public	JJ
cord-333722-ndth5zne	11	16	health	health	NN
cord-333722-ndth5zne	11	17	systems	system	NNS
cord-333722-ndth5zne	11	18	and	and	CC
cord-333722-ndth5zne	11	19	incur	incur	VB
cord-333722-ndth5zne	11	20	economic	economic	JJ
cord-333722-ndth5zne	11	21	costs	cost	NNS
cord-333722-ndth5zne	11	22	to	to	IN
cord-333722-ndth5zne	11	23	both	both	DT
cord-333722-ndth5zne	11	24	individuals	individual	NNS
cord-333722-ndth5zne	11	25	and	and	CC
cord-333722-ndth5zne	11	26	countries	country	NNS
cord-333722-ndth5zne	11	27	.	.	.
cord-333722-ndth5zne	12	1	The	the	DT
cord-333722-ndth5zne	12	2	influenza	influenza	NN
cord-333722-ndth5zne	12	3	virus	virus	NN
cord-333722-ndth5zne	12	4	is	be	VBZ
cord-333722-ndth5zne	12	5	a	a	DT
cord-333722-ndth5zne	12	6	main	main	JJ
cord-333722-ndth5zne	12	7	cause	cause	NN
cord-333722-ndth5zne	12	8	of	of	IN
cord-333722-ndth5zne	12	9	those	those	DT
cord-333722-ndth5zne	12	10	threats	threat	NNS
cord-333722-ndth5zne	12	11	and	and	CC
cord-333722-ndth5zne	12	12	is	be	VBZ
cord-333722-ndth5zne	12	13	responsible	responsible	JJ
cord-333722-ndth5zne	12	14	for	for	IN
cord-333722-ndth5zne	12	15	millions	million	NNS
cord-333722-ndth5zne	12	16	of	of	IN
cord-333722-ndth5zne	12	17	severe	severe	JJ
cord-333722-ndth5zne	12	18	cases	case	NNS
cord-333722-ndth5zne	12	19	and	and	CC
cord-333722-ndth5zne	12	20	250	250	CD
cord-333722-ndth5zne	12	21	000	000	CD
cord-333722-ndth5zne	12	22	-	-	HYPH
cord-333722-ndth5zne	12	23	500	500	CD
cord-333722-ndth5zne	12	24	000	000	CD
cord-333722-ndth5zne	12	25	deaths	death	NNS
cord-333722-ndth5zne	12	26	each	each	DT
cord-333722-ndth5zne	12	27	year	year	NN
cord-333722-ndth5zne	12	28	.	.	.
cord-333722-ndth5zne	13	1	1	1	LS
cord-333722-ndth5zne	14	1	The	the	DT
cord-333722-ndth5zne	14	2	scenario	scenario	NN
cord-333722-ndth5zne	14	3	can	can	MD
cord-333722-ndth5zne	14	4	be	be	VB
cord-333722-ndth5zne	14	5	even	even	RB
cord-333722-ndth5zne	14	6	worse	bad	JJR
cord-333722-ndth5zne	14	7	during	during	IN
cord-333722-ndth5zne	14	8	a	a	DT
cord-333722-ndth5zne	14	9	pandemic	pandemic	NN
cord-333722-ndth5zne	14	10	year	year	NN
cord-333722-ndth5zne	14	11	.	.	.
cord-333722-ndth5zne	15	1	The	the	DT
cord-333722-ndth5zne	15	2	most	most	RBS
cord-333722-ndth5zne	15	3	virulent	virulent	JJ
cord-333722-ndth5zne	15	4	influenza	influenza	NN
cord-333722-ndth5zne	15	5	,	,	,
cord-333722-ndth5zne	15	6	the	the	DT
cord-333722-ndth5zne	15	7	1918	1918	CD
cord-333722-ndth5zne	15	8	H1N1	H1N1	NNP
cord-333722-ndth5zne	15	9	Spanish	spanish	JJ
cord-333722-ndth5zne	15	10	flu	flu	NN
cord-333722-ndth5zne	15	11	,	,	,
cord-333722-ndth5zne	15	12	infected	infect	VBN
cord-333722-ndth5zne	15	13	approximately	approximately	RB
cord-333722-ndth5zne	15	14	5	5	CD
cord-333722-ndth5zne	15	15	%	%	NN
cord-333722-ndth5zne	15	16	of	of	IN
cord-333722-ndth5zne	15	17	the	the	DT
cord-333722-ndth5zne	15	18	world	world	NN
cord-333722-ndth5zne	15	19	's	's	POS
cord-333722-ndth5zne	15	20	population	population	NN
cord-333722-ndth5zne	15	21	and	and	CC
cord-333722-ndth5zne	15	22	killed	kill	VBD
cord-333722-ndth5zne	15	23	2	2	CD
cord-333722-ndth5zne	15	24	%	%	NN
cord-333722-ndth5zne	15	25	.	.	.
cord-333722-ndth5zne	16	1	2	2	LS
cord-333722-ndth5zne	17	1	The	the	DT
cord-333722-ndth5zne	17	2	case	case	NN
cord-333722-ndth5zne	17	3	fatality	fatality	NN
cord-333722-ndth5zne	17	4	rates	rate	NNS
cord-333722-ndth5zne	17	5	for	for	IN
cord-333722-ndth5zne	17	6	the	the	DT
cord-333722-ndth5zne	17	7	1957	1957	CD
cord-333722-ndth5zne	17	8	H2N2	H2N2	NNP
cord-333722-ndth5zne	17	9	Asian	asian	JJ
cord-333722-ndth5zne	17	10	influenza	influenza	NN
cord-333722-ndth5zne	17	11	,	,	,
cord-333722-ndth5zne	17	12	the	the	DT
cord-333722-ndth5zne	17	13	1968	1968	CD
cord-333722-ndth5zne	17	14	H3N2	H3N2	NNP
cord-333722-ndth5zne	17	15	Hong	Hong	NNP
cord-333722-ndth5zne	17	16	Kong	Kong	NNP
cord-333722-ndth5zne	17	17	influenza	influenza	NN
cord-333722-ndth5zne	17	18	,	,	,
cord-333722-ndth5zne	17	19	and	and	CC
cord-333722-ndth5zne	17	20	the	the	DT
cord-333722-ndth5zne	17	21	2009	2009	CD
cord-333722-ndth5zne	17	22	H1N1	H1N1	NNP
cord-333722-ndth5zne	17	23	pandemic	pandemic	NN
cord-333722-ndth5zne	17	24	influenza	influenza	NN
cord-333722-ndth5zne	17	25	were	be	VBD
cord-333722-ndth5zne	17	26	reported	report	VBN
cord-333722-ndth5zne	17	27	to	to	TO
cord-333722-ndth5zne	17	28	be	be	VB
cord-333722-ndth5zne	17	29	lower	low	JJR
cord-333722-ndth5zne	17	30	,	,	,
cord-333722-ndth5zne	17	31	with	with	IN
cord-333722-ndth5zne	17	32	an	an	DT
cord-333722-ndth5zne	17	33	estimated	estimate	VBN
cord-333722-ndth5zne	17	34	rate	rate	NN
cord-333722-ndth5zne	17	35	of	of	IN
cord-333722-ndth5zne	17	36	0.2	0.2	CD
cord-333722-ndth5zne	17	37	%	%	NN
cord-333722-ndth5zne	17	38	or	or	CC
cord-333722-ndth5zne	17	39	less	less	JJR
cord-333722-ndth5zne	17	40	.	.	.
cord-333722-ndth5zne	18	1	3	3	LS
cord-333722-ndth5zne	19	1	Most	most	RBS
cord-333722-ndth5zne	19	2	alarmingly	alarmingly	RB
cord-333722-ndth5zne	19	3	,	,	,
cord-333722-ndth5zne	19	4	between	between	IN
cord-333722-ndth5zne	19	5	1997	1997	CD
cord-333722-ndth5zne	19	6	and	and	CC
cord-333722-ndth5zne	19	7	2014	2014	CD
cord-333722-ndth5zne	19	8	,	,	,
cord-333722-ndth5zne	19	9	several	several	JJ
cord-333722-ndth5zne	19	10	unprecedented	unprecedented	JJ
cord-333722-ndth5zne	19	11	epizootic	epizootic	JJ
cord-333722-ndth5zne	19	12	avian	avian	JJ
cord-333722-ndth5zne	19	13	influenza	influenza	NN
cord-333722-ndth5zne	19	14	viruses	virus	NNS
cord-333722-ndth5zne	19	15	(	(	-LRB-
cord-333722-ndth5zne	19	16	e.g.	e.g.	RB
cord-333722-ndth5zne	19	17	,	,	,
cord-333722-ndth5zne	19	18	H5N1	H5N1	NNP
cord-333722-ndth5zne	19	19	,	,	,
cord-333722-ndth5zne	19	20	H7N9	H7N9	NNP
cord-333722-ndth5zne	19	21	,	,	,
cord-333722-ndth5zne	19	22	and	and	CC
cord-333722-ndth5zne	19	23	H10N8	H10N8	NNP
cord-333722-ndth5zne	19	24	)	)	-RRB-
cord-333722-ndth5zne	19	25	crossed	cross	VBD
cord-333722-ndth5zne	19	26	the	the	DT
cord-333722-ndth5zne	19	27	species	specie	NNS
cord-333722-ndth5zne	19	28	barrier	barrier	NN
cord-333722-ndth5zne	19	29	to	to	TO
cord-333722-ndth5zne	19	30	cause	cause	VB
cord-333722-ndth5zne	19	31	human	human	JJ
cord-333722-ndth5zne	19	32	death	death	NN
cord-333722-ndth5zne	19	33	.	.	.
cord-333722-ndth5zne	20	1	They	-PRON-	PRP
cord-333722-ndth5zne	20	2	pose	pose	VBP
cord-333722-ndth5zne	20	3	an	an	DT
cord-333722-ndth5zne	20	4	increasing	increase	VBG
cord-333722-ndth5zne	20	5	threat	threat	NN
cord-333722-ndth5zne	20	6	of	of	IN
cord-333722-ndth5zne	20	7	human	human	NN
cord-333722-ndth5zne	20	8	-	-	HYPH
cord-333722-ndth5zne	20	9	to	to	IN
cord-333722-ndth5zne	20	10	-	-	HYPH
cord-333722-ndth5zne	20	11	human	human	JJ
cord-333722-ndth5zne	20	12	transmission	transmission	NN
cord-333722-ndth5zne	20	13	.	.	.
cord-333722-ndth5zne	21	1	4,5	4,5	LS
cord-333722-ndth5zne	22	1	These	these	DT
cord-333722-ndth5zne	22	2	infections	infection	NNS
cord-333722-ndth5zne	22	3	in	in	IN
cord-333722-ndth5zne	22	4	humans	human	NNS
cord-333722-ndth5zne	22	5	are	be	VBP
cord-333722-ndth5zne	22	6	accompanied	accompany	VBN
cord-333722-ndth5zne	22	7	by	by	IN
cord-333722-ndth5zne	22	8	an	an	DT
cord-333722-ndth5zne	22	9	aggressive	aggressive	JJ
cord-333722-ndth5zne	22	10	pro	pro	JJ
cord-333722-ndth5zne	22	11	-	-	JJ
cord-333722-ndth5zne	22	12	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	22	13	response	response	NN
cord-333722-ndth5zne	22	14	and	and	CC
cord-333722-ndth5zne	22	15	insufficient	insufficient	JJ
cord-333722-ndth5zne	22	16	control	control	NN
cord-333722-ndth5zne	22	17	of	of	IN
cord-333722-ndth5zne	22	18	an	an	DT
cord-333722-ndth5zne	22	19	anti	anti	JJ
cord-333722-ndth5zne	22	20	-	-	JJ
cord-333722-ndth5zne	22	21	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	22	22	response	response	NN
cord-333722-ndth5zne	22	23	,	,	,
cord-333722-ndth5zne	22	24	a	a	DT
cord-333722-ndth5zne	22	25	combination	combination	NN
cord-333722-ndth5zne	22	26	of	of	IN
cord-333722-ndth5zne	22	27	events	event	NNS
cord-333722-ndth5zne	22	28	called	call	VBN
cord-333722-ndth5zne	22	29	'	'	``
cord-333722-ndth5zne	22	30	cytokine	cytokine	NN
cord-333722-ndth5zne	22	31	storm	storm	NN
cord-333722-ndth5zne	22	32	'	'	''
cord-333722-ndth5zne	22	33	.	.	.
cord-333722-ndth5zne	23	1	In	in	IN
cord-333722-ndth5zne	23	2	the	the	DT
cord-333722-ndth5zne	23	3	event	event	NN
cord-333722-ndth5zne	23	4	of	of	IN
cord-333722-ndth5zne	23	5	influenza	influenza	NN
cord-333722-ndth5zne	23	6	infection	infection	NN
cord-333722-ndth5zne	23	7	,	,	,
cord-333722-ndth5zne	23	8	the	the	DT
cord-333722-ndth5zne	23	9	severity	severity	NN
cord-333722-ndth5zne	23	10	of	of	IN
cord-333722-ndth5zne	23	11	disease	disease	NN
cord-333722-ndth5zne	23	12	is	be	VBZ
cord-333722-ndth5zne	23	13	the	the	DT
cord-333722-ndth5zne	23	14	result	result	NN
cord-333722-ndth5zne	23	15	of	of	IN
cord-333722-ndth5zne	23	16	the	the	DT
cord-333722-ndth5zne	23	17	interplay	interplay	NN
cord-333722-ndth5zne	23	18	between	between	IN
cord-333722-ndth5zne	23	19	viral	viral	JJ
cord-333722-ndth5zne	23	20	virulence	virulence	NN
cord-333722-ndth5zne	23	21	and	and	CC
cord-333722-ndth5zne	23	22	host	host	NN
cord-333722-ndth5zne	23	23	resistance	resistance	NN
cord-333722-ndth5zne	23	24	.	.	.
cord-333722-ndth5zne	24	1	In	in	IN
cord-333722-ndth5zne	24	2	mild	mild	JJ
cord-333722-ndth5zne	24	3	infection	infection	NN
cord-333722-ndth5zne	24	4	,	,	,
cord-333722-ndth5zne	24	5	the	the	DT
cord-333722-ndth5zne	24	6	host	host	NN
cord-333722-ndth5zne	24	7	has	have	VBZ
cord-333722-ndth5zne	24	8	a	a	DT
cord-333722-ndth5zne	24	9	limited	limited	JJ
cord-333722-ndth5zne	24	10	or	or	CC
cord-333722-ndth5zne	24	11	moderate	moderate	JJ
cord-333722-ndth5zne	24	12	resistance	resistance	NN
cord-333722-ndth5zne	24	13	,	,	,
cord-333722-ndth5zne	24	14	so	so	CC
cord-333722-ndth5zne	24	15	the	the	DT
cord-333722-ndth5zne	24	16	disrupted	disrupt	VBN
cord-333722-ndth5zne	24	17	homeostasis	homeostasis	NN
cord-333722-ndth5zne	24	18	is	be	VBZ
cord-333722-ndth5zne	24	19	restored	restore	VBN
cord-333722-ndth5zne	24	20	rapidly	rapidly	RB
cord-333722-ndth5zne	24	21	.	.	.
cord-333722-ndth5zne	25	1	However	however	RB
cord-333722-ndth5zne	25	2	,	,	,
cord-333722-ndth5zne	25	3	for	for	IN
cord-333722-ndth5zne	25	4	infections	infection	NNS
cord-333722-ndth5zne	25	5	caused	cause	VBN
cord-333722-ndth5zne	25	6	by	by	IN
cord-333722-ndth5zne	25	7	the	the	DT
cord-333722-ndth5zne	25	8	1918	1918	CD
cord-333722-ndth5zne	25	9	H1N1	H1N1	NNP
cord-333722-ndth5zne	25	10	or	or	CC
cord-333722-ndth5zne	25	11	the	the	DT
cord-333722-ndth5zne	25	12	H5N1	H5N1	NNP
cord-333722-ndth5zne	25	13	influenzas	influenza	NNS
cord-333722-ndth5zne	25	14	virus	virus	NN
cord-333722-ndth5zne	25	15	,	,	,
cord-333722-ndth5zne	25	16	the	the	DT
cord-333722-ndth5zne	25	17	resistance	resistance	NN
cord-333722-ndth5zne	25	18	became	become	VBD
cord-333722-ndth5zne	25	19	hyperactive	hyperactive	JJ
cord-333722-ndth5zne	25	20	,	,	,
cord-333722-ndth5zne	25	21	resulting	result	VBG
cord-333722-ndth5zne	25	22	in	in	IN
cord-333722-ndth5zne	25	23	an	an	DT
cord-333722-ndth5zne	25	24	excessive	excessive	JJ
cord-333722-ndth5zne	25	25	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	25	26	reaction	reaction	NN
cord-333722-ndth5zne	25	27	known	know	VBN
cord-333722-ndth5zne	25	28	as	as	IN
cord-333722-ndth5zne	25	29	the	the	DT
cord-333722-ndth5zne	25	30	cytokine	cytokine	NN
cord-333722-ndth5zne	25	31	storm	storm	NN
cord-333722-ndth5zne	25	32	phenomenon	phenomenon	NN
cord-333722-ndth5zne	25	33	.	.	.
cord-333722-ndth5zne	26	1	6	6	CD
cord-333722-ndth5zne	26	2	Several	several	JJ
cord-333722-ndth5zne	26	3	experimental	experimental	JJ
cord-333722-ndth5zne	26	4	studies	study	NNS
cord-333722-ndth5zne	26	5	and	and	CC
cord-333722-ndth5zne	26	6	clinical	clinical	JJ
cord-333722-ndth5zne	26	7	trials	trial	NNS
cord-333722-ndth5zne	26	8	suggested	suggest	VBD
cord-333722-ndth5zne	26	9	that	that	IN
cord-333722-ndth5zne	26	10	cytokine	cytokine	NN
cord-333722-ndth5zne	26	11	storm	storm	NN
cord-333722-ndth5zne	26	12	correlated	correlate	VBD
cord-333722-ndth5zne	26	13	directly	directly	RB
cord-333722-ndth5zne	26	14	with	with	IN
cord-333722-ndth5zne	26	15	tissue	tissue	NN
cord-333722-ndth5zne	26	16	injury	injury	NN
cord-333722-ndth5zne	26	17	and	and	CC
cord-333722-ndth5zne	26	18	an	an	DT
cord-333722-ndth5zne	26	19	unfavorable	unfavorable	JJ
cord-333722-ndth5zne	26	20	prognosis	prognosis	NN
cord-333722-ndth5zne	26	21	of	of	IN
cord-333722-ndth5zne	26	22	severe	severe	JJ
cord-333722-ndth5zne	26	23	influenza	influenza	NN
cord-333722-ndth5zne	26	24	.	.	.
cord-333722-ndth5zne	27	1	7	7	CD
cord-333722-ndth5zne	28	1	However	however	RB
cord-333722-ndth5zne	28	2	,	,	,
cord-333722-ndth5zne	28	3	our	-PRON-	PRP$
cord-333722-ndth5zne	28	4	understanding	understanding	NN
cord-333722-ndth5zne	28	5	of	of	IN
cord-333722-ndth5zne	28	6	the	the	DT
cord-333722-ndth5zne	28	7	mechanism	mechanism	NN
cord-333722-ndth5zne	28	8	that	that	WDT
cord-333722-ndth5zne	28	9	promotes	promote	VBZ
cord-333722-ndth5zne	28	10	a	a	DT
cord-333722-ndth5zne	28	11	cytokine	cytokine	NN
cord-333722-ndth5zne	28	12	storm	storm	NN
cord-333722-ndth5zne	28	13	remains	remain	VBZ
cord-333722-ndth5zne	28	14	limited	limited	JJ
cord-333722-ndth5zne	28	15	.	.	.
cord-333722-ndth5zne	29	1	In	in	IN
cord-333722-ndth5zne	29	2	this	this	DT
cord-333722-ndth5zne	29	3	review	review	NN
cord-333722-ndth5zne	29	4	,	,	,
cord-333722-ndth5zne	29	5	we	-PRON-	PRP
cord-333722-ndth5zne	29	6	focus	focus	VBP
cord-333722-ndth5zne	29	7	on	on	IN
cord-333722-ndth5zne	29	8	the	the	DT
cord-333722-ndth5zne	29	9	potential	potential	JJ
cord-333722-ndth5zne	29	10	mechanisms	mechanism	NNS
cord-333722-ndth5zne	29	11	responsible	responsible	JJ
cord-333722-ndth5zne	29	12	for	for	IN
cord-333722-ndth5zne	29	13	severe	severe	JJ
cord-333722-ndth5zne	29	14	influenza	influenza	NN
cord-333722-ndth5zne	29	15	-	-	HYPH
cord-333722-ndth5zne	29	16	induced	induce	VBN
cord-333722-ndth5zne	29	17	cytokine	cytokine	NN
cord-333722-ndth5zne	29	18	storm	storm	NN
cord-333722-ndth5zne	29	19	and	and	CC
cord-333722-ndth5zne	29	20	the	the	DT
cord-333722-ndth5zne	29	21	therapeutic	therapeutic	JJ
cord-333722-ndth5zne	29	22	strategies	strategy	NNS
cord-333722-ndth5zne	29	23	that	that	WDT
cord-333722-ndth5zne	29	24	might	may	MD
cord-333722-ndth5zne	29	25	be	be	VB
cord-333722-ndth5zne	29	26	used	use	VBN
cord-333722-ndth5zne	29	27	to	to	TO
cord-333722-ndth5zne	29	28	improve	improve	VB
cord-333722-ndth5zne	29	29	the	the	DT
cord-333722-ndth5zne	29	30	clinical	clinical	JJ
cord-333722-ndth5zne	29	31	prognosis	prognosis	NN
cord-333722-ndth5zne	29	32	of	of	IN
cord-333722-ndth5zne	29	33	these	these	DT
cord-333722-ndth5zne	29	34	infections	infection	NNS
cord-333722-ndth5zne	29	35	.	.	.
cord-333722-ndth5zne	30	1	viruses	virus	NNS
cord-333722-ndth5zne	30	2	that	that	WDT
cord-333722-ndth5zne	30	3	proliferate	proliferate	VBP
cord-333722-ndth5zne	30	4	within	within	IN
cord-333722-ndth5zne	30	5	these	these	DT
cord-333722-ndth5zne	30	6	cells	cell	NNS
cord-333722-ndth5zne	30	7	can	can	MD
cord-333722-ndth5zne	30	8	infect	infect	VB
cord-333722-ndth5zne	30	9	other	other	JJ
cord-333722-ndth5zne	30	10	cells	cell	NNS
cord-333722-ndth5zne	30	11	,	,	,
cord-333722-ndth5zne	30	12	including	include	VBG
cord-333722-ndth5zne	30	13	alveolar	alveolar	JJ
cord-333722-ndth5zne	30	14	macrophages	macrophage	NNS
cord-333722-ndth5zne	30	15	.	.	.
cord-333722-ndth5zne	31	1	9	9	CD
cord-333722-ndth5zne	31	2	Inflammatory	inflammatory	JJ
cord-333722-ndth5zne	31	3	responses	response	NNS
cord-333722-ndth5zne	31	4	are	be	VBP
cord-333722-ndth5zne	31	5	triggered	trigger	VBN
cord-333722-ndth5zne	31	6	when	when	WRB
cord-333722-ndth5zne	31	7	infected	infected	JJ
cord-333722-ndth5zne	31	8	cells	cell	NNS
cord-333722-ndth5zne	31	9	die	die	VBP
cord-333722-ndth5zne	31	10	by	by	IN
cord-333722-ndth5zne	31	11	apoptosis	apoptosis	NN
cord-333722-ndth5zne	31	12	or	or	CC
cord-333722-ndth5zne	31	13	necrosis	necrosis	NN
cord-333722-ndth5zne	31	14	.	.	.
cord-333722-ndth5zne	32	1	3	3	LS
cord-333722-ndth5zne	33	1	The	the	DT
cord-333722-ndth5zne	33	2	initial	initial	JJ
cord-333722-ndth5zne	33	3	response	response	NN
cord-333722-ndth5zne	33	4	of	of	IN
cord-333722-ndth5zne	33	5	the	the	DT
cord-333722-ndth5zne	33	6	organism	organism	NN
cord-333722-ndth5zne	33	7	to	to	IN
cord-333722-ndth5zne	33	8	harmful	harmful	JJ
cord-333722-ndth5zne	33	9	stimuli	stimulus	NNS
cord-333722-ndth5zne	33	10	is	be	VBZ
cord-333722-ndth5zne	33	11	acute	acute	JJ
cord-333722-ndth5zne	33	12	inflammation	inflammation	NN
cord-333722-ndth5zne	33	13	and	and	CC
cord-333722-ndth5zne	33	14	is	be	VBZ
cord-333722-ndth5zne	33	15	characterized	characterize	VBN
cord-333722-ndth5zne	33	16	by	by	IN
cord-333722-ndth5zne	33	17	increasing	increase	VBG
cord-333722-ndth5zne	33	18	blood	blood	NN
cord-333722-ndth5zne	33	19	flow	flow	NN
cord-333722-ndth5zne	33	20	,	,	,
cord-333722-ndth5zne	33	21	which	which	WDT
cord-333722-ndth5zne	33	22	enables	enable	VBZ
cord-333722-ndth5zne	33	23	plasma	plasma	NN
cord-333722-ndth5zne	33	24	and	and	CC
cord-333722-ndth5zne	33	25	leukocytes	leukocyte	NNS
cord-333722-ndth5zne	33	26	to	to	TO
cord-333722-ndth5zne	33	27	reach	reach	VB
cord-333722-ndth5zne	33	28	extra	extra	JJ
cord-333722-ndth5zne	33	29	-	-	JJ
cord-333722-ndth5zne	33	30	vascular	vascular	JJ
cord-333722-ndth5zne	33	31	sites	site	NNS
cord-333722-ndth5zne	33	32	of	of	IN
cord-333722-ndth5zne	33	33	injury	injury	NN
cord-333722-ndth5zne	33	34	,	,	,
cord-333722-ndth5zne	33	35	elevating	elevate	VBG
cord-333722-ndth5zne	33	36	local	local	JJ
cord-333722-ndth5zne	33	37	temperatures	temperature	NNS
cord-333722-ndth5zne	33	38	,	,	,
cord-333722-ndth5zne	33	39	and	and	CC
cord-333722-ndth5zne	33	40	causing	cause	VBG
cord-333722-ndth5zne	33	41	pain	pain	NN
cord-333722-ndth5zne	33	42	.	.	.
cord-333722-ndth5zne	34	1	3	3	LS
cord-333722-ndth5zne	35	1	The	the	DT
cord-333722-ndth5zne	35	2	acute	acute	JJ
cord-333722-ndth5zne	35	3	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	35	4	response	response	NN
cord-333722-ndth5zne	35	5	is	be	VBZ
cord-333722-ndth5zne	35	6	also	also	RB
cord-333722-ndth5zne	35	7	marked	mark	VBN
cord-333722-ndth5zne	35	8	by	by	IN
cord-333722-ndth5zne	35	9	the	the	DT
cord-333722-ndth5zne	35	10	activation	activation	NN
cord-333722-ndth5zne	35	11	of	of	IN
cord-333722-ndth5zne	35	12	pro	pro	JJ
cord-333722-ndth5zne	35	13	-	-	JJ
cord-333722-ndth5zne	35	14	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	35	15	cytokines	cytokine	NNS
cord-333722-ndth5zne	35	16	or	or	CC
cord-333722-ndth5zne	35	17	chemokines	chemokine	NNS
cord-333722-ndth5zne	35	18	.	.	.
cord-333722-ndth5zne	36	1	9,10	9,10	CD
cord-333722-ndth5zne	37	1	These	these	DT
cord-333722-ndth5zne	37	2	pro	pro	JJ
cord-333722-ndth5zne	37	3	-	-	JJ
cord-333722-ndth5zne	37	4	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	37	5	cytokines	cytokine	NNS
cord-333722-ndth5zne	37	6	or	or	CC
cord-333722-ndth5zne	37	7	chemokines	chemokine	NNS
cord-333722-ndth5zne	37	8	can	can	MD
cord-333722-ndth5zne	37	9	lead	lead	VB
cord-333722-ndth5zne	37	10	to	to	IN
cord-333722-ndth5zne	37	11	the	the	DT
cord-333722-ndth5zne	37	12	recruitment	recruitment	NN
cord-333722-ndth5zne	37	13	of	of	IN
cord-333722-ndth5zne	37	14	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	37	15	cells	cell	NNS
cord-333722-ndth5zne	37	16	.	.	.
cord-333722-ndth5zne	38	1	9	9	CD
cord-333722-ndth5zne	38	2	,	,	,
cord-333722-ndth5zne	38	3	10	10	CD
cord-333722-ndth5zne	39	1	Then	then	RB
cord-333722-ndth5zne	39	2	,	,	,
cord-333722-ndth5zne	39	3	an	an	DT
cord-333722-ndth5zne	39	4	increasing	increase	VBG
cord-333722-ndth5zne	39	5	expression	expression	NN
cord-333722-ndth5zne	39	6	of	of	IN
cord-333722-ndth5zne	39	7	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	39	8	,	,	,
cord-333722-ndth5zne	39	9	antiviral	antiviral	JJ
cord-333722-ndth5zne	39	10	,	,	,
cord-333722-ndth5zne	39	11	and	and	CC
cord-333722-ndth5zne	39	12	apoptotic	apoptotic	JJ
cord-333722-ndth5zne	39	13	genes	gene	NNS
cord-333722-ndth5zne	39	14	occurs	occur	VBZ
cord-333722-ndth5zne	39	15	accompanied	accompany	VBN
cord-333722-ndth5zne	39	16	by	by	IN
cord-333722-ndth5zne	39	17	abundant	abundant	JJ
cord-333722-ndth5zne	39	18	immune	immune	JJ
cord-333722-ndth5zne	39	19	cell	cell	NN
cord-333722-ndth5zne	39	20	infiltration	infiltration	NN
cord-333722-ndth5zne	39	21	and	and	CC
cord-333722-ndth5zne	39	22	tissue	tissue	NN
cord-333722-ndth5zne	39	23	damage	damage	NN
cord-333722-ndth5zne	39	24	7	7	CD
cord-333722-ndth5zne	39	25	,	,	,
cord-333722-ndth5zne	39	26	11	11	CD
cord-333722-ndth5zne	39	27	(	(	-LRB-
cord-333722-ndth5zne	39	28	Figure	figure	NN
cord-333722-ndth5zne	39	29	1	1	CD
cord-333722-ndth5zne	39	30	)	)	-RRB-
cord-333722-ndth5zne	39	31	.	.	.
cord-333722-ndth5zne	40	1	At	at	IN
cord-333722-ndth5zne	40	2	the	the	DT
cord-333722-ndth5zne	40	3	same	same	JJ
cord-333722-ndth5zne	40	4	time	time	NN
cord-333722-ndth5zne	40	5	,	,	,
cord-333722-ndth5zne	40	6	regenerative	regenerative	JJ
cord-333722-ndth5zne	40	7	processes	process	NNS
cord-333722-ndth5zne	40	8	and	and	CC
cord-333722-ndth5zne	40	9	resolution	resolution	NN
cord-333722-ndth5zne	40	10	of	of	IN
cord-333722-ndth5zne	40	11	the	the	DT
cord-333722-ndth5zne	40	12	damage	damage	NN
cord-333722-ndth5zne	40	13	are	be	VBP
cord-333722-ndth5zne	40	14	initiated	initiate	VBN
cord-333722-ndth5zne	40	15	.	.	.
cord-333722-ndth5zne	41	1	In	in	IN
cord-333722-ndth5zne	41	2	most	most	JJS
cord-333722-ndth5zne	41	3	cases	case	NNS
cord-333722-ndth5zne	41	4	,	,	,
cord-333722-ndth5zne	41	5	function	function	NN
cord-333722-ndth5zne	41	6	can	can	MD
cord-333722-ndth5zne	41	7	be	be	VB
cord-333722-ndth5zne	41	8	completely	completely	RB
cord-333722-ndth5zne	41	9	restored	restore	VBN
cord-333722-ndth5zne	41	10	by	by	IN
cord-333722-ndth5zne	41	11	this	this	DT
cord-333722-ndth5zne	41	12	reparative	reparative	JJ
cord-333722-ndth5zne	41	13	process	process	NN
cord-333722-ndth5zne	41	14	.	.	.
cord-333722-ndth5zne	42	1	12	12	CD
cord-333722-ndth5zne	43	1	However	however	RB
cord-333722-ndth5zne	43	2	,	,	,
cord-333722-ndth5zne	43	3	for	for	IN
cord-333722-ndth5zne	43	4	severe	severe	JJ
cord-333722-ndth5zne	43	5	inflammation	inflammation	NN
cord-333722-ndth5zne	43	6	associated	associate	VBN
cord-333722-ndth5zne	43	7	with	with	IN
cord-333722-ndth5zne	43	8	cytokine	cytokine	NN
cord-333722-ndth5zne	43	9	storm	storm	NN
cord-333722-ndth5zne	43	10	,	,	,
cord-333722-ndth5zne	43	11	more	more	RBR
cord-333722-ndth5zne	43	12	serious	serious	JJ
cord-333722-ndth5zne	43	13	pathological	pathological	JJ
cord-333722-ndth5zne	43	14	changes	change	NNS
cord-333722-ndth5zne	43	15	are	be	VBP
cord-333722-ndth5zne	43	16	observed	observe	VBN
cord-333722-ndth5zne	43	17	,	,	,
cord-333722-ndth5zne	43	18	such	such	JJ
cord-333722-ndth5zne	43	19	as	as	IN
cord-333722-ndth5zne	43	20	diffuse	diffuse	JJ
cord-333722-ndth5zne	43	21	alveolar	alveolar	NN
cord-333722-ndth5zne	43	22	damage	damage	NN
cord-333722-ndth5zne	43	23	,	,	,
cord-333722-ndth5zne	43	24	hyaline	hyaline	JJ
cord-333722-ndth5zne	43	25	membrane	membrane	NN
cord-333722-ndth5zne	43	26	formation	formation	NN
cord-333722-ndth5zne	43	27	,	,	,
cord-333722-ndth5zne	43	28	fibrin	fibrin	NN
cord-333722-ndth5zne	43	29	exudates	exudate	NNS
cord-333722-ndth5zne	43	30	,	,	,
cord-333722-ndth5zne	43	31	and	and	CC
cord-333722-ndth5zne	43	32	fibrotic	fibrotic	JJ
cord-333722-ndth5zne	43	33	healing	healing	NN
cord-333722-ndth5zne	43	34	.	.	.
cord-333722-ndth5zne	44	1	10	10	CD
cord-333722-ndth5zne	45	1	These	these	DT
cord-333722-ndth5zne	45	2	are	be	VBP
cord-333722-ndth5zne	45	3	signs	sign	NNS
cord-333722-ndth5zne	45	4	of	of	IN
cord-333722-ndth5zne	45	5	severe	severe	JJ
cord-333722-ndth5zne	45	6	capillary	capillary	JJ
cord-333722-ndth5zne	45	7	damage	damage	NN
cord-333722-ndth5zne	45	8	,	,	,
cord-333722-ndth5zne	45	9	immunopathologic	immunopathologic	JJ
cord-333722-ndth5zne	45	10	injury	injury	NN
cord-333722-ndth5zne	45	11	,	,	,
cord-333722-ndth5zne	45	12	and	and	CC
cord-333722-ndth5zne	45	13	persistent	persistent	JJ
cord-333722-ndth5zne	45	14	organ	organ	NN
cord-333722-ndth5zne	45	15	dysfunction	dysfunction	NN
cord-333722-ndth5zne	45	16	.	.	.
cord-333722-ndth5zne	46	1	10	10	CD
cord-333722-ndth5zne	47	1	Moreover	moreover	RB
cord-333722-ndth5zne	47	2	,	,	,
cord-333722-ndth5zne	47	3	the	the	DT
cord-333722-ndth5zne	47	4	severe	severe	JJ
cord-333722-ndth5zne	47	5	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	47	6	cytokines	cytokine	NNS
cord-333722-ndth5zne	47	7	/	/	SYM
cord-333722-ndth5zne	47	8	chemokines	chemokine	NNS
cord-333722-ndth5zne	47	9	can	can	MD
cord-333722-ndth5zne	47	10	spill	spill	VB
cord-333722-ndth5zne	47	11	over	over	RP
cord-333722-ndth5zne	47	12	into	into	IN
cord-333722-ndth5zne	47	13	the	the	DT
cord-333722-ndth5zne	47	14	circulation	circulation	NN
cord-333722-ndth5zne	47	15	and	and	CC
cord-333722-ndth5zne	47	16	result	result	VB
cord-333722-ndth5zne	47	17	in	in	IN
cord-333722-ndth5zne	47	18	systemic	systemic	JJ
cord-333722-ndth5zne	47	19	cytokine	cytokine	NN
cord-333722-ndth5zne	47	20	storms	storm	NNS
cord-333722-ndth5zne	47	21	,	,	,
cord-333722-ndth5zne	47	22	which	which	WDT
cord-333722-ndth5zne	47	23	are	be	VBP
cord-333722-ndth5zne	47	24	responsible	responsible	JJ
cord-333722-ndth5zne	47	25	for	for	IN
cord-333722-ndth5zne	47	26	multi	multi	JJ
cord-333722-ndth5zne	47	27	-	-	JJ
cord-333722-ndth5zne	47	28	organ	organ	JJ
cord-333722-ndth5zne	47	29	dysfunction	dysfunction	NN
cord-333722-ndth5zne	47	30	.	.	.
cord-333722-ndth5zne	48	1	7	7	CD
cord-333722-ndth5zne	49	1	The	the	DT
cord-333722-ndth5zne	49	2	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	49	3	response	response	NN
cord-333722-ndth5zne	49	4	begins	begin	VBZ
cord-333722-ndth5zne	49	5	when	when	WRB
cord-333722-ndth5zne	49	6	the	the	DT
cord-333722-ndth5zne	49	7	pathogen	pathogen	NN
cord-333722-ndth5zne	49	8	-	-	HYPH
cord-333722-ndth5zne	49	9	associated	associate	VBN
cord-333722-ndth5zne	49	10	molecular	molecular	JJ
cord-333722-ndth5zne	49	11	pattern	pattern	NN
cord-333722-ndth5zne	49	12	(	(	-LRB-
cord-333722-ndth5zne	49	13	PAMP	PAMP	NNP
cord-333722-ndth5zne	49	14	)	)	-RRB-
cord-333722-ndth5zne	49	15	from	from	IN
cord-333722-ndth5zne	49	16	the	the	DT
cord-333722-ndth5zne	49	17	virus	virus	NN
cord-333722-ndth5zne	49	18	is	be	VBZ
cord-333722-ndth5zne	49	19	recognized	recognize	VBN
cord-333722-ndth5zne	49	20	by	by	IN
cord-333722-ndth5zne	49	21	the	the	DT
cord-333722-ndth5zne	49	22	pattern	pattern	NN
cord-333722-ndth5zne	49	23	recognition	recognition	NN
cord-333722-ndth5zne	49	24	receptors	receptor	NNS
cord-333722-ndth5zne	49	25	(	(	-LRB-
cord-333722-ndth5zne	49	26	PRRs	PRRs	NNP
cord-333722-ndth5zne	49	27	)	)	-RRB-
cord-333722-ndth5zne	49	28	of	of	IN
cord-333722-ndth5zne	49	29	innate	innate	JJ
cord-333722-ndth5zne	49	30	immune	immune	JJ
cord-333722-ndth5zne	49	31	cells	cell	NNS
cord-333722-ndth5zne	49	32	.	.	.
cord-333722-ndth5zne	50	1	13	13	CD
cord-333722-ndth5zne	50	2	,	,	,
cord-333722-ndth5zne	50	3	14	14	CD
cord-333722-ndth5zne	51	1	Then	then	RB
cord-333722-ndth5zne	51	2	,	,	,
cord-333722-ndth5zne	51	3	specific	specific	JJ
cord-333722-ndth5zne	51	4	pro	pro	JJ
cord-333722-ndth5zne	51	5	-	-	JJ
cord-333722-ndth5zne	51	6	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	51	7	cytokines	cytokine	NNS
cord-333722-ndth5zne	51	8	are	be	VBP
cord-333722-ndth5zne	51	9	expressed	express	VBN
cord-333722-ndth5zne	51	10	after	after	IN
cord-333722-ndth5zne	51	11	the	the	DT
cord-333722-ndth5zne	51	12	downstream	downstream	JJ
cord-333722-ndth5zne	51	13	signaling	signaling	NN
cord-333722-ndth5zne	52	1	cascades	cascade	NNS
cord-333722-ndth5zne	52	2	of	of	IN
cord-333722-ndth5zne	52	3	PRRs	prr	NNS
cord-333722-ndth5zne	52	4	are	be	VBP
cord-333722-ndth5zne	52	5	triggered	trigger	VBN
cord-333722-ndth5zne	52	6	by	by	IN
cord-333722-ndth5zne	52	7	(	(	-LRB-
cord-333722-ndth5zne	52	8	1	1	CD
cord-333722-ndth5zne	52	9	)	)	-RRB-
cord-333722-ndth5zne	52	10	Viruses	virus	NNS
cord-333722-ndth5zne	52	11	infect	infect	VBP
cord-333722-ndth5zne	52	12	lung	lung	NN
cord-333722-ndth5zne	52	13	epithelial	epithelial	JJ
cord-333722-ndth5zne	52	14	cells	cell	NNS
cord-333722-ndth5zne	52	15	and	and	CC
cord-333722-ndth5zne	52	16	alveolar	alveolar	JJ
cord-333722-ndth5zne	52	17	macrophages	macrophage	NNS
cord-333722-ndth5zne	52	18	to	to	TO
cord-333722-ndth5zne	52	19	produce	produce	VB
cord-333722-ndth5zne	52	20	progeny	progeny	NN
cord-333722-ndth5zne	52	21	viruses	virus	NNS
cord-333722-ndth5zne	52	22	and	and	CC
cord-333722-ndth5zne	52	23	release	release	VB
cord-333722-ndth5zne	52	24	cytokines	cytokine	NNS
cord-333722-ndth5zne	52	25	/	/	SYM
cord-333722-ndth5zne	52	26	chemokines	chemokine	NNS
cord-333722-ndth5zne	52	27	(	(	-LRB-
cord-333722-ndth5zne	52	28	mainly	mainly	RB
cord-333722-ndth5zne	52	29	contains	contain	VBZ
cord-333722-ndth5zne	52	30	interferons	interferon	NNS
cord-333722-ndth5zne	52	31	)	)	-RRB-
cord-333722-ndth5zne	52	32	.	.	.
cord-333722-ndth5zne	53	1	(	(	-LRB-
cord-333722-ndth5zne	53	2	2	2	LS
cord-333722-ndth5zne	53	3	)	)	-RRB-
cord-333722-ndth5zne	53	4	Cytokine	cytokine	NN
cord-333722-ndth5zne	53	5	/	/	SYM
cord-333722-ndth5zne	53	6	chemokine	chemokine	NN
cord-333722-ndth5zne	53	7	-	-	HYPH
cord-333722-ndth5zne	53	8	activated	activate	VBN
cord-333722-ndth5zne	53	9	macrophages	macrophage	NNS
cord-333722-ndth5zne	53	10	and	and	CC
cord-333722-ndth5zne	53	11	virally	virally	RB
cord-333722-ndth5zne	53	12	infected	infect	VBN
cord-333722-ndth5zne	53	13	dendritic	dendritic	JJ
cord-333722-ndth5zne	53	14	cells	cell	NNS
cord-333722-ndth5zne	53	15	lead	lead	VBP
cord-333722-ndth5zne	53	16	to	to	IN
cord-333722-ndth5zne	53	17	a	a	DT
cord-333722-ndth5zne	53	18	more	more	RBR
cord-333722-ndth5zne	53	19	extensive	extensive	JJ
cord-333722-ndth5zne	53	20	immune	immune	JJ
cord-333722-ndth5zne	53	21	response	response	NN
cord-333722-ndth5zne	53	22	and	and	CC
cord-333722-ndth5zne	53	23	the	the	DT
cord-333722-ndth5zne	53	24	initiation	initiation	NN
cord-333722-ndth5zne	53	25	of	of	IN
cord-333722-ndth5zne	53	26	cytokine	cytokine	NN
cord-333722-ndth5zne	53	27	storm	storm	NN
cord-333722-ndth5zne	53	28	.	.	.
cord-333722-ndth5zne	54	1	(	(	-LRB-
cord-333722-ndth5zne	54	2	3	3	LS
cord-333722-ndth5zne	54	3	)	)	-RRB-
cord-333722-ndth5zne	54	4	Released	release	VBN
cord-333722-ndth5zne	54	5	chemokines	chemokine	NNS
cord-333722-ndth5zne	54	6	attract	attract	VBP
cord-333722-ndth5zne	54	7	more	more	JJR
cord-333722-ndth5zne	54	8	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	54	9	cells	cell	NNS
cord-333722-ndth5zne	54	10	to	to	TO
cord-333722-ndth5zne	54	11	migrate	migrate	VB
cord-333722-ndth5zne	54	12	from	from	IN
cord-333722-ndth5zne	54	13	blood	blood	NN
cord-333722-ndth5zne	54	14	vessels	vessel	NNS
cord-333722-ndth5zne	54	15	into	into	IN
cord-333722-ndth5zne	54	16	the	the	DT
cord-333722-ndth5zne	54	17	site	site	NN
cord-333722-ndth5zne	54	18	of	of	IN
cord-333722-ndth5zne	54	19	inflammation	inflammation	NN
cord-333722-ndth5zne	54	20	,	,	,
cord-333722-ndth5zne	54	21	and	and	CC
cord-333722-ndth5zne	54	22	these	these	DT
cord-333722-ndth5zne	54	23	cells	cell	NNS
cord-333722-ndth5zne	54	24	release	release	VBP
cord-333722-ndth5zne	54	25	additional	additional	JJ
cord-333722-ndth5zne	54	26	chemokines	chemokine	NNS
cord-333722-ndth5zne	54	27	/	/	SYM
cord-333722-ndth5zne	54	28	cytokines	cytokine	NNS
cord-333722-ndth5zne	54	29	to	to	TO
cord-333722-ndth5zne	54	30	amplify	amplify	VB
cord-333722-ndth5zne	54	31	cytokine	cytokine	JJ
cord-333722-ndth5zne	54	32	storm	storm	NN
cord-333722-ndth5zne	54	33	.	.	.
cord-333722-ndth5zne	55	1	Cytokine	cytokine	NN
cord-333722-ndth5zne	55	2	storm	storm	NN
cord-333722-ndth5zne	55	3	Q	Q	NNP
cord-333722-ndth5zne	55	4	Liu	Liu	NNP
cord-333722-ndth5zne	55	5	et	et	FW
cord-333722-ndth5zne	55	6	al	al	NNP
cord-333722-ndth5zne	55	7	stimuli	stimulus	NNS
cord-333722-ndth5zne	55	8	.	.	.
cord-333722-ndth5zne	56	1	14	14	CD
cord-333722-ndth5zne	56	2	Researchers	researcher	NNS
cord-333722-ndth5zne	56	3	have	have	VBP
cord-333722-ndth5zne	56	4	a	a	DT
cord-333722-ndth5zne	56	5	great	great	JJ
cord-333722-ndth5zne	56	6	interest	interest	NN
cord-333722-ndth5zne	56	7	in	in	IN
cord-333722-ndth5zne	56	8	exploring	explore	VBG
cord-333722-ndth5zne	56	9	the	the	DT
cord-333722-ndth5zne	56	10	association	association	NN
cord-333722-ndth5zne	56	11	between	between	IN
cord-333722-ndth5zne	56	12	polymorphisms	polymorphism	NNS
cord-333722-ndth5zne	56	13	of	of	IN
cord-333722-ndth5zne	56	14	PRRs	prr	NNS
cord-333722-ndth5zne	56	15	and	and	CC
cord-333722-ndth5zne	56	16	host	host	NN
cord-333722-ndth5zne	56	17	susceptibility	susceptibility	NN
cord-333722-ndth5zne	56	18	to	to	IN
cord-333722-ndth5zne	56	19	cytokine	cytokine	JJ
cord-333722-ndth5zne	56	20	storm	storm	NN
cord-333722-ndth5zne	56	21	,	,	,
cord-333722-ndth5zne	56	22	which	which	WDT
cord-333722-ndth5zne	56	23	may	may	MD
cord-333722-ndth5zne	56	24	help	help	VB
cord-333722-ndth5zne	56	25	explain	explain	VB
cord-333722-ndth5zne	56	26	why	why	WRB
cord-333722-ndth5zne	56	27	some	some	DT
cord-333722-ndth5zne	56	28	individuals	individual	NNS
cord-333722-ndth5zne	56	29	,	,	,
cord-333722-ndth5zne	56	30	but	but	CC
cord-333722-ndth5zne	56	31	not	not	RB
cord-333722-ndth5zne	56	32	others	other	NNS
cord-333722-ndth5zne	56	33	,	,	,
cord-333722-ndth5zne	56	34	seem	seem	VBP
cord-333722-ndth5zne	56	35	relatively	relatively	RB
cord-333722-ndth5zne	56	36	resistant	resistant	JJ
cord-333722-ndth5zne	56	37	to	to	IN
cord-333722-ndth5zne	56	38	cytokine	cytokine	JJ
cord-333722-ndth5zne	56	39	storm	storm	NN
cord-333722-ndth5zne	56	40	.	.	.
cord-333722-ndth5zne	57	1	15	15	CD
cord-333722-ndth5zne	57	2	Severe	severe	JJ
cord-333722-ndth5zne	57	3	cytokine	cytokine	NN
cord-333722-ndth5zne	57	4	storm	storm	NN
cord-333722-ndth5zne	57	5	,	,	,
cord-333722-ndth5zne	57	6	with	with	IN
cord-333722-ndth5zne	57	7	markedly	markedly	RB
cord-333722-ndth5zne	57	8	higher	high	JJR
cord-333722-ndth5zne	57	9	levels	level	NNS
cord-333722-ndth5zne	57	10	of	of	IN
cord-333722-ndth5zne	57	11	proinflammatory	proinflammatory	JJ
cord-333722-ndth5zne	57	12	cytokines	cytokine	NNS
cord-333722-ndth5zne	57	13	including	include	VBG
cord-333722-ndth5zne	57	14	interferons	interferon	NNS
cord-333722-ndth5zne	57	15	(	(	-LRB-
cord-333722-ndth5zne	57	16	IFNs	IFNs	NNP
cord-333722-ndth5zne	57	17	)	)	-RRB-
cord-333722-ndth5zne	57	18	,	,	,
cord-333722-ndth5zne	57	19	tumor	tumor	NN
cord-333722-ndth5zne	57	20	necrosis	necrosis	NN
cord-333722-ndth5zne	57	21	factors	factor	NNS
cord-333722-ndth5zne	57	22	(	(	-LRB-
cord-333722-ndth5zne	57	23	TNFs	TNFs	NNP
cord-333722-ndth5zne	57	24	)	)	-RRB-
cord-333722-ndth5zne	57	25	,	,	,
cord-333722-ndth5zne	57	26	interleukins	interleukin	NNS
cord-333722-ndth5zne	57	27	(	(	-LRB-
cord-333722-ndth5zne	57	28	ILs	ILs	NNP
cord-333722-ndth5zne	57	29	)	)	-RRB-
cord-333722-ndth5zne	57	30	,	,	,
cord-333722-ndth5zne	57	31	and	and	CC
cord-333722-ndth5zne	57	32	chemokines	chemokine	NNS
cord-333722-ndth5zne	57	33	,	,	,
cord-333722-ndth5zne	57	34	has	have	VBZ
cord-333722-ndth5zne	57	35	been	be	VBN
cord-333722-ndth5zne	57	36	detected	detect	VBN
cord-333722-ndth5zne	57	37	in	in	IN
cord-333722-ndth5zne	57	38	patients	patient	NNS
cord-333722-ndth5zne	57	39	hospitalized	hospitalize	VBN
cord-333722-ndth5zne	57	40	with	with	IN
cord-333722-ndth5zne	57	41	severe	severe	JJ
cord-333722-ndth5zne	57	42	influenza	influenza	NN
cord-333722-ndth5zne	57	43	infections	infection	NNS
cord-333722-ndth5zne	57	44	.	.	.
cord-333722-ndth5zne	58	1	16	16	CD
cord-333722-ndth5zne	58	2	Severe	severe	JJ
cord-333722-ndth5zne	58	3	cytokine	cytokine	NN
cord-333722-ndth5zne	58	4	storm	storm	NN
cord-333722-ndth5zne	58	5	is	be	VBZ
cord-333722-ndth5zne	58	6	rarely	rarely	RB
cord-333722-ndth5zne	58	7	observed	observe	VBN
cord-333722-ndth5zne	58	8	in	in	IN
cord-333722-ndth5zne	58	9	seasonal	seasonal	JJ
cord-333722-ndth5zne	58	10	and	and	CC
cord-333722-ndth5zne	58	11	other	other	JJ
cord-333722-ndth5zne	58	12	mild	mild	JJ
cord-333722-ndth5zne	58	13	influenza	influenza	NN
cord-333722-ndth5zne	58	14	,	,	,
cord-333722-ndth5zne	58	15	17	17	CD
cord-333722-ndth5zne	58	16	indicating	indicate	VBG
cord-333722-ndth5zne	58	17	that	that	IN
cord-333722-ndth5zne	58	18	high	high	JJ
cord-333722-ndth5zne	58	19	cytokine/	cytokine/	CD
cord-333722-ndth5zne	58	20	chemokine	chemokine	NN
cord-333722-ndth5zne	58	21	levels	level	NNS
cord-333722-ndth5zne	58	22	correlate	correlate	VBP
cord-333722-ndth5zne	58	23	strongly	strongly	RB
cord-333722-ndth5zne	58	24	with	with	IN
cord-333722-ndth5zne	58	25	disease	disease	NN
cord-333722-ndth5zne	58	26	severity	severity	NN
cord-333722-ndth5zne	58	27	.	.	.
cord-333722-ndth5zne	59	1	The	the	DT
cord-333722-ndth5zne	59	2	interferon	interferon	NN
cord-333722-ndth5zne	59	3	family	family	NN
cord-333722-ndth5zne	59	4	has	have	VBZ
cord-333722-ndth5zne	59	5	a	a	DT
cord-333722-ndth5zne	59	6	critical	critical	JJ
cord-333722-ndth5zne	59	7	role	role	NN
cord-333722-ndth5zne	59	8	in	in	IN
cord-333722-ndth5zne	59	9	the	the	DT
cord-333722-ndth5zne	59	10	innate	innate	JJ
cord-333722-ndth5zne	59	11	immune	immune	JJ
cord-333722-ndth5zne	59	12	response	response	NN
cord-333722-ndth5zne	59	13	to	to	IN
cord-333722-ndth5zne	59	14	viruses	virus	NNS
cord-333722-ndth5zne	59	15	.	.	.
cord-333722-ndth5zne	60	1	18	18	CD
cord-333722-ndth5zne	61	1	A	a	DT
cord-333722-ndth5zne	61	2	number	number	NN
cord-333722-ndth5zne	61	3	of	of	IN
cord-333722-ndth5zne	61	4	proteins	protein	NNS
cord-333722-ndth5zne	61	5	with	with	IN
cord-333722-ndth5zne	61	6	antiviral	antiviral	JJ
cord-333722-ndth5zne	61	7	or	or	CC
cord-333722-ndth5zne	61	8	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	61	9	properties	property	NNS
cord-333722-ndth5zne	61	10	are	be	VBP
cord-333722-ndth5zne	61	11	produced	produce	VBN
cord-333722-ndth5zne	61	12	once	once	IN
cord-333722-ndth5zne	61	13	the	the	DT
cord-333722-ndth5zne	61	14	IFN	IFN	NNP
cord-333722-ndth5zne	61	15	signaling	signal	VBG
cord-333722-ndth5zne	61	16	pathway	pathway	NN
cord-333722-ndth5zne	61	17	is	be	VBZ
cord-333722-ndth5zne	61	18	activated	activate	VBN
cord-333722-ndth5zne	61	19	.	.	.
cord-333722-ndth5zne	62	1	18	18	CD
cord-333722-ndth5zne	63	1	Although	although	IN
cord-333722-ndth5zne	63	2	overproduction	overproduction	NN
cord-333722-ndth5zne	63	3	of	of	IN
cord-333722-ndth5zne	63	4	IFN	IFN	NNP
cord-333722-ndth5zne	63	5	in	in	IN
cord-333722-ndth5zne	63	6	the	the	DT
cord-333722-ndth5zne	63	7	early	early	JJ
cord-333722-ndth5zne	63	8	stage	stage	NN
cord-333722-ndth5zne	63	9	of	of	IN
cord-333722-ndth5zne	63	10	infection	infection	NN
cord-333722-ndth5zne	63	11	likely	likely	RB
cord-333722-ndth5zne	63	12	leads	lead	VBZ
cord-333722-ndth5zne	63	13	to	to	IN
cord-333722-ndth5zne	63	14	irreversible	irreversible	JJ
cord-333722-ndth5zne	63	15	lung	lung	NN
cord-333722-ndth5zne	63	16	damage	damage	NN
cord-333722-ndth5zne	63	17	in	in	IN
cord-333722-ndth5zne	63	18	H5N1-infected	h5n1-infected	JJ
cord-333722-ndth5zne	63	19	mice	mouse	NNS
cord-333722-ndth5zne	63	20	,	,	,
cord-333722-ndth5zne	63	21	the	the	DT
cord-333722-ndth5zne	63	22	IFN	IFN	NNP
cord-333722-ndth5zne	63	23	signaling	signal	VBG
cord-333722-ndth5zne	63	24	pathway	pathway	NN
cord-333722-ndth5zne	63	25	may	may	MD
cord-333722-ndth5zne	63	26	also	also	RB
cord-333722-ndth5zne	63	27	be	be	VB
cord-333722-ndth5zne	63	28	important	important	JJ
cord-333722-ndth5zne	63	29	in	in	IN
cord-333722-ndth5zne	63	30	restricting	restrict	VBG
cord-333722-ndth5zne	63	31	the	the	DT
cord-333722-ndth5zne	63	32	dissemination	dissemination	NN
cord-333722-ndth5zne	63	33	of	of	IN
cord-333722-ndth5zne	63	34	H5N1	H5N1	NNP
cord-333722-ndth5zne	63	35	viruses	virus	NNS
cord-333722-ndth5zne	63	36	.	.	.
cord-333722-ndth5zne	64	1	18	18	CD
cord-333722-ndth5zne	64	2	,	,	,
cord-333722-ndth5zne	64	3	19	19	CD
cord-333722-ndth5zne	64	4	TNF	TNF	NNP
cord-333722-ndth5zne	64	5	-	-	:
cord-333722-ndth5zne	64	6	a	a	NNP
cord-333722-ndth5zne	64	7	is	be	VBZ
cord-333722-ndth5zne	64	8	a	a	DT
cord-333722-ndth5zne	64	9	key	key	JJ
cord-333722-ndth5zne	64	10	cytokine	cytokine	NN
cord-333722-ndth5zne	64	11	in	in	IN
cord-333722-ndth5zne	64	12	cytokine	cytokine	JJ
cord-333722-ndth5zne	64	13	storm	storm	NN
cord-333722-ndth5zne	64	14	and	and	CC
cord-333722-ndth5zne	64	15	is	be	VBZ
cord-333722-ndth5zne	64	16	likely	likely	JJ
cord-333722-ndth5zne	64	17	to	to	TO
cord-333722-ndth5zne	64	18	account	account	VB
cord-333722-ndth5zne	64	19	for	for	IN
cord-333722-ndth5zne	64	20	the	the	DT
cord-333722-ndth5zne	64	21	escalation	escalation	NN
cord-333722-ndth5zne	64	22	in	in	IN
cord-333722-ndth5zne	64	23	severity	severity	NN
cord-333722-ndth5zne	64	24	.	.	.
cord-333722-ndth5zne	65	1	12	12	CD
cord-333722-ndth5zne	66	1	However	however	RB
cord-333722-ndth5zne	66	2	,	,	,
cord-333722-ndth5zne	66	3	TNF	TNF	NNP
cord-333722-ndth5zne	66	4	receptor	receptor	NN
cord-333722-ndth5zne	66	5	2/2	2/2	CD
cord-333722-ndth5zne	66	6	mice	mouse	NNS
cord-333722-ndth5zne	66	7	,	,	,
cord-333722-ndth5zne	66	8	or	or	CC
cord-333722-ndth5zne	66	9	mice	mouse	NNS
cord-333722-ndth5zne	66	10	treated	treat	VBN
cord-333722-ndth5zne	66	11	with	with	IN
cord-333722-ndth5zne	66	12	anti	anti	JJ
cord-333722-ndth5zne	66	13	-	-	JJ
cord-333722-ndth5zne	66	14	TNF	tnf	NN
cord-333722-ndth5zne	66	15	-	-	HYPH
cord-333722-ndth5zne	66	16	antibodies	antibody	NNS
cord-333722-ndth5zne	66	17	,	,	,
cord-333722-ndth5zne	66	18	have	have	VBP
cord-333722-ndth5zne	66	19	no	no	DT
cord-333722-ndth5zne	66	20	changes	change	NNS
cord-333722-ndth5zne	66	21	in	in	IN
cord-333722-ndth5zne	66	22	survival	survival	NN
cord-333722-ndth5zne	66	23	when	when	WRB
cord-333722-ndth5zne	66	24	compared	compare	VBN
cord-333722-ndth5zne	66	25	with	with	IN
cord-333722-ndth5zne	66	26	controls	control	NNS
cord-333722-ndth5zne	66	27	following	follow	VBG
cord-333722-ndth5zne	66	28	a	a	DT
cord-333722-ndth5zne	66	29	challenge	challenge	NN
cord-333722-ndth5zne	66	30	with	with	IN
cord-333722-ndth5zne	66	31	the	the	DT
cord-333722-ndth5zne	66	32	H5N1	H5N1	NNP
cord-333722-ndth5zne	66	33	virus	virus	NN
cord-333722-ndth5zne	66	34	.	.	.
cord-333722-ndth5zne	67	1	12	12	CD
cord-333722-ndth5zne	67	2	IL-1	IL-1	NNP
cord-333722-ndth5zne	67	3	and	and	CC
cord-333722-ndth5zne	67	4	IL-6	IL-6	NNP
cord-333722-ndth5zne	67	5	are	be	VBP
cord-333722-ndth5zne	67	6	the	the	DT
cord-333722-ndth5zne	67	7	main	main	JJ
cord-333722-ndth5zne	67	8	pro	pro	JJ
cord-333722-ndth5zne	67	9	-	-	JJ
cord-333722-ndth5zne	67	10	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	67	11	cytokines	cytokine	NNS
cord-333722-ndth5zne	67	12	released	release	VBN
cord-333722-ndth5zne	67	13	by	by	IN
cord-333722-ndth5zne	67	14	hosts	host	NNS
cord-333722-ndth5zne	67	15	during	during	IN
cord-333722-ndth5zne	67	16	viral	viral	JJ
cord-333722-ndth5zne	67	17	infections	infection	NNS
cord-333722-ndth5zne	67	18	.	.	.
cord-333722-ndth5zne	68	1	IL-1	IL-1	NNP
cord-333722-ndth5zne	68	2	is	be	VBZ
cord-333722-ndth5zne	68	3	expressed	express	VBN
cord-333722-ndth5zne	68	4	in	in	IN
cord-333722-ndth5zne	68	5	the	the	DT
cord-333722-ndth5zne	68	6	early	early	JJ
cord-333722-ndth5zne	68	7	stages	stage	NNS
cord-333722-ndth5zne	68	8	of	of	IN
cord-333722-ndth5zne	68	9	infection	infection	NN
cord-333722-ndth5zne	68	10	,	,	,
cord-333722-ndth5zne	68	11	followed	follow	VBN
cord-333722-ndth5zne	68	12	by	by	IN
cord-333722-ndth5zne	68	13	an	an	DT
cord-333722-ndth5zne	68	14	increasing	increase	VBG
cord-333722-ndth5zne	68	15	expression	expression	NN
cord-333722-ndth5zne	68	16	of	of	IN
cord-333722-ndth5zne	68	17	IL-6	IL-6	NNP
cord-333722-ndth5zne	68	18	.	.	.
cord-333722-ndth5zne	68	19	7	7	CD
cord-333722-ndth5zne	68	20	IL-1	IL-1	NNP
cord-333722-ndth5zne	68	21	receptor	receptor	NN
cord-333722-ndth5zne	68	22	signaling	signaling	NN
cord-333722-ndth5zne	68	23	is	be	VBZ
cord-333722-ndth5zne	68	24	responsible	responsible	JJ
cord-333722-ndth5zne	68	25	for	for	IN
cord-333722-ndth5zne	68	26	acute	acute	JJ
cord-333722-ndth5zne	68	27	the	the	DT
cord-333722-ndth5zne	68	28	immunopathology	immunopathology	NN
cord-333722-ndth5zne	68	29	of	of	IN
cord-333722-ndth5zne	68	30	tissue	tissue	NN
cord-333722-ndth5zne	68	31	,	,	,
cord-333722-ndth5zne	68	32	and	and	CC
cord-333722-ndth5zne	68	33	IL-1	IL-1	NNP
cord-333722-ndth5zne	68	34	receptor	receptor	NN
cord-333722-ndth5zne	68	35	2/2	2/2	CD
cord-333722-ndth5zne	68	36	mice	mouse	NNS
cord-333722-ndth5zne	68	37	were	be	VBD
cord-333722-ndth5zne	68	38	shown	show	VBN
cord-333722-ndth5zne	68	39	to	to	TO
cord-333722-ndth5zne	68	40	have	have	VB
cord-333722-ndth5zne	68	41	a	a	DT
cord-333722-ndth5zne	68	42	worse	bad	JJR
cord-333722-ndth5zne	68	43	outcome	outcome	NN
cord-333722-ndth5zne	68	44	after	after	IN
cord-333722-ndth5zne	68	45	H5N1	H5N1	NNP
cord-333722-ndth5zne	68	46	infection	infection	NN
cord-333722-ndth5zne	68	47	.	.	.
cord-333722-ndth5zne	69	1	This	this	DT
cord-333722-ndth5zne	69	2	suggests	suggest	VBZ
cord-333722-ndth5zne	69	3	that	that	IN
cord-333722-ndth5zne	69	4	the	the	DT
cord-333722-ndth5zne	69	5	pathways	pathway	NNS
cord-333722-ndth5zne	69	6	are	be	VBP
cord-333722-ndth5zne	69	7	protective	protective	JJ
cord-333722-ndth5zne	69	8	.	.	.
cord-333722-ndth5zne	70	1	7	7	CD
cord-333722-ndth5zne	71	1	Unlike	unlike	IN
cord-333722-ndth5zne	71	2	pro	pro	JJ
cord-333722-ndth5zne	71	3	-	-	JJ
cord-333722-ndth5zne	71	4	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	71	5	cytokines	cytokine	NNS
cord-333722-ndth5zne	71	6	,	,	,
cord-333722-ndth5zne	71	7	chemokines	chemokine	NNS
cord-333722-ndth5zne	71	8	often	often	RB
cord-333722-ndth5zne	71	9	have	have	VBP
cord-333722-ndth5zne	71	10	specific	specific	JJ
cord-333722-ndth5zne	71	11	chemotactic	chemotactic	JJ
cord-333722-ndth5zne	71	12	activities	activity	NNS
cord-333722-ndth5zne	71	13	that	that	WDT
cord-333722-ndth5zne	71	14	enable	enable	VBP
cord-333722-ndth5zne	71	15	monocytes	monocyte	NNS
cord-333722-ndth5zne	71	16	and	and	CC
cord-333722-ndth5zne	71	17	Tlymphocytes	Tlymphocytes	NNPS
cord-333722-ndth5zne	71	18	to	to	TO
cord-333722-ndth5zne	71	19	migrate	migrate	VB
cord-333722-ndth5zne	71	20	from	from	IN
cord-333722-ndth5zne	71	21	blood	blood	NN
cord-333722-ndth5zne	71	22	vessels	vessel	NNS
cord-333722-ndth5zne	71	23	into	into	IN
cord-333722-ndth5zne	71	24	the	the	DT
cord-333722-ndth5zne	71	25	site	site	NN
cord-333722-ndth5zne	71	26	of	of	IN
cord-333722-ndth5zne	71	27	inflammation	inflammation	NN
cord-333722-ndth5zne	71	28	.	.	.
cord-333722-ndth5zne	72	1	9	9	CD
cord-333722-ndth5zne	73	1	For	for	IN
cord-333722-ndth5zne	73	2	example	example	NN
cord-333722-ndth5zne	73	3	,	,	,
cord-333722-ndth5zne	73	4	IL-8	IL-8	NNP
cord-333722-ndth5zne	73	5	and	and	CC
cord-333722-ndth5zne	73	6	monocyte	monocyte	NNP
cord-333722-ndth5zne	73	7	chemoattractant	chemoattractant	NNP
cord-333722-ndth5zne	73	8	protein	protein	NN
cord-333722-ndth5zne	73	9	(	(	-LRB-
cord-333722-ndth5zne	73	10	MCP)-1	MCP)-1	NNP
cord-333722-ndth5zne	73	11	are	be	VBP
cord-333722-ndth5zne	73	12	major	major	JJ
cord-333722-ndth5zne	73	13	chemotactic	chemotactic	JJ
cord-333722-ndth5zne	73	14	factors	factor	NNS
cord-333722-ndth5zne	73	15	for	for	IN
cord-333722-ndth5zne	73	16	neutrophils	neutrophil	NNS
cord-333722-ndth5zne	73	17	and	and	CC
cord-333722-ndth5zne	73	18	monocytes	monocyte	NNS
cord-333722-ndth5zne	73	19	,	,	,
cord-333722-ndth5zne	73	20	respectively	respectively	RB
cord-333722-ndth5zne	73	21	.	.	.
cord-333722-ndth5zne	74	1	It	-PRON-	PRP
cord-333722-ndth5zne	74	2	should	should	MD
cord-333722-ndth5zne	74	3	be	be	VB
cord-333722-ndth5zne	74	4	noted	note	VBN
cord-333722-ndth5zne	74	5	that	that	IN
cord-333722-ndth5zne	74	6	the	the	DT
cord-333722-ndth5zne	74	7	levels	level	NNS
cord-333722-ndth5zne	74	8	of	of	IN
cord-333722-ndth5zne	74	9	IL-8	il-8	NN
cord-333722-ndth5zne	74	10	,	,	,
cord-333722-ndth5zne	74	11	interferon	interferon	NN
cord-333722-ndth5zne	74	12	-	-	HYPH
cord-333722-ndth5zne	74	13	induced	induce	VBN
cord-333722-ndth5zne	74	14	protein	protein	NN
cord-333722-ndth5zne	74	15	(	(	-LRB-
cord-333722-ndth5zne	74	16	IP)-10	IP)-10	NNP
cord-333722-ndth5zne	74	17	,	,	,
cord-333722-ndth5zne	74	18	MCP-1	MCP-1	NNP
cord-333722-ndth5zne	74	19	,	,	,
cord-333722-ndth5zne	74	20	macrophage	macrophage	NN
cord-333722-ndth5zne	74	21	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	74	22	protein	protein	NN
cord-333722-ndth5zne	74	23	(	(	-LRB-
cord-333722-ndth5zne	74	24	MIP)-1	MIP)-1	NNP
cord-333722-ndth5zne	74	25	,	,	,
cord-333722-ndth5zne	74	26	and	and	CC
cord-333722-ndth5zne	74	27	monokines	monokine	NNS
cord-333722-ndth5zne	74	28	induced	induce	VBN
cord-333722-ndth5zne	74	29	by	by	IN
cord-333722-ndth5zne	74	30	IFN	IFN	NNP
cord-333722-ndth5zne	74	31	-	-	HYPH
cord-333722-ndth5zne	74	32	c	c	NNP
cord-333722-ndth5zne	74	33	(	(	-LRB-
cord-333722-ndth5zne	74	34	MIG	MIG	NNP
cord-333722-ndth5zne	74	35	)	)	-RRB-
cord-333722-ndth5zne	74	36	were	be	VBD
cord-333722-ndth5zne	74	37	abnormally	abnormally	RB
cord-333722-ndth5zne	74	38	elevated	elevate	VBN
cord-333722-ndth5zne	74	39	in	in	IN
cord-333722-ndth5zne	74	40	some	some	DT
cord-333722-ndth5zne	74	41	fatal	fatal	JJ
cord-333722-ndth5zne	74	42	cases	case	NNS
cord-333722-ndth5zne	74	43	of	of	IN
cord-333722-ndth5zne	74	44	H5N1	H5N1	NNP
cord-333722-ndth5zne	74	45	influenza	influenza	NN
cord-333722-ndth5zne	74	46	infection	infection	NN
cord-333722-ndth5zne	74	47	and	and	CC
cord-333722-ndth5zne	74	48	that	that	IN
cord-333722-ndth5zne	74	49	IL-8	IL-8	NNP
cord-333722-ndth5zne	74	50	had	have	VBD
cord-333722-ndth5zne	74	51	the	the	DT
cord-333722-ndth5zne	74	52	highest	high	JJS
cord-333722-ndth5zne	74	53	level	level	NN
cord-333722-ndth5zne	74	54	among	among	IN
cord-333722-ndth5zne	74	55	them	-PRON-	PRP
cord-333722-ndth5zne	74	56	.	.	.
cord-333722-ndth5zne	75	1	20	20	CD
cord-333722-ndth5zne	76	1	MIP-1	mip-1	NN
cord-333722-ndth5zne	76	2	2/2	2/2	CD
cord-333722-ndth5zne	76	3	mice	mouse	NNS
cord-333722-ndth5zne	76	4	exhibit	exhibit	VBP
cord-333722-ndth5zne	76	5	inefficient	inefficient	JJ
cord-333722-ndth5zne	76	6	viral	viral	JJ
cord-333722-ndth5zne	76	7	clearance	clearance	NN
cord-333722-ndth5zne	76	8	but	but	CC
cord-333722-ndth5zne	76	9	reduced	reduce	VBN
cord-333722-ndth5zne	76	10	mortality	mortality	NN
cord-333722-ndth5zne	76	11	and	and	CC
cord-333722-ndth5zne	76	12	lung	lung	NN
cord-333722-ndth5zne	76	13	damage	damage	NN
cord-333722-ndth5zne	76	14	.	.	.
cord-333722-ndth5zne	77	1	9	9	CD
cord-333722-ndth5zne	78	1	Several	several	JJ
cord-333722-ndth5zne	78	2	studies	study	NNS
cord-333722-ndth5zne	78	3	9,21	9,21	NNP
cord-333722-ndth5zne	78	4	also	also	RB
cord-333722-ndth5zne	78	5	investigated	investigate	VBD
cord-333722-ndth5zne	78	6	the	the	DT
cord-333722-ndth5zne	78	7	roles	role	NNS
cord-333722-ndth5zne	78	8	of	of	IN
cord-333722-ndth5zne	78	9	several	several	JJ
cord-333722-ndth5zne	78	10	chemokine	chemokine	NN
cord-333722-ndth5zne	78	11	receptors	receptor	NNS
cord-333722-ndth5zne	78	12	,	,	,
cord-333722-ndth5zne	78	13	such	such	JJ
cord-333722-ndth5zne	78	14	as	as	IN
cord-333722-ndth5zne	78	15	the	the	DT
cord-333722-ndth5zne	78	16	MIP-1	MIP-1	NNP
cord-333722-ndth5zne	78	17	receptor	receptor	NN
cord-333722-ndth5zne	78	18	CCR5	CCR5	NNP
cord-333722-ndth5zne	78	19	and	and	CC
cord-333722-ndth5zne	78	20	the	the	DT
cord-333722-ndth5zne	78	21	MCP-1	MCP-1	NNP
cord-333722-ndth5zne	78	22	primary	primary	JJ
cord-333722-ndth5zne	78	23	receptor	receptor	NN
cord-333722-ndth5zne	78	24	CCR2	CCR2	NNP
cord-333722-ndth5zne	78	25	,	,	,
cord-333722-ndth5zne	78	26	in	in	IN
cord-333722-ndth5zne	78	27	severe	severe	JJ
cord-333722-ndth5zne	78	28	influenza	influenza	NN
cord-333722-ndth5zne	78	29	infections	infection	NNS
cord-333722-ndth5zne	78	30	.	.	.
cord-333722-ndth5zne	79	1	Interestingly	interestingly	RB
cord-333722-ndth5zne	79	2	,	,	,
cord-333722-ndth5zne	79	3	CCR5	CCR5	NNP
cord-333722-ndth5zne	79	4	2/2	2/2	CD
cord-333722-ndth5zne	79	5	mice	mouse	NNS
cord-333722-ndth5zne	79	6	displayed	display	VBD
cord-333722-ndth5zne	79	7	an	an	DT
cord-333722-ndth5zne	79	8	excessive	excessive	JJ
cord-333722-ndth5zne	79	9	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	79	10	response	response	NN
cord-333722-ndth5zne	79	11	and	and	CC
cord-333722-ndth5zne	79	12	increased	increase	VBN
cord-333722-ndth5zne	79	13	mortality	mortality	NN
cord-333722-ndth5zne	79	14	,	,	,
cord-333722-ndth5zne	79	15	while	while	IN
cord-333722-ndth5zne	79	16	CCR2	CCR2	NNP
cord-333722-ndth5zne	79	17	2/2	2/2	CD
cord-333722-ndth5zne	79	18	mice	mouse	NNS
cord-333722-ndth5zne	79	19	displayed	display	VBD
cord-333722-ndth5zne	79	20	a	a	DT
cord-333722-ndth5zne	79	21	decreased	decrease	VBN
cord-333722-ndth5zne	79	22	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	79	23	response	response	NN
cord-333722-ndth5zne	79	24	and	and	CC
cord-333722-ndth5zne	79	25	mortality	mortality	NN
cord-333722-ndth5zne	79	26	but	but	CC
cord-333722-ndth5zne	79	27	developed	develop	VBD
cord-333722-ndth5zne	79	28	a	a	DT
cord-333722-ndth5zne	79	29	significantly	significantly	RB
cord-333722-ndth5zne	79	30	elevated	elevate	VBN
cord-333722-ndth5zne	79	31	viral	viral	JJ
cord-333722-ndth5zne	79	32	load	load	NN
cord-333722-ndth5zne	79	33	.	.	.
cord-333722-ndth5zne	80	1	21	21	CD
cord-333722-ndth5zne	81	1	This	this	DT
cord-333722-ndth5zne	81	2	evidence	evidence	NN
cord-333722-ndth5zne	81	3	partly	partly	RB
cord-333722-ndth5zne	81	4	suggests	suggest	VBZ
cord-333722-ndth5zne	81	5	that	that	IN
cord-333722-ndth5zne	81	6	the	the	DT
cord-333722-ndth5zne	81	7	pathology	pathology	NN
cord-333722-ndth5zne	81	8	of	of	IN
cord-333722-ndth5zne	81	9	severe	severe	JJ
cord-333722-ndth5zne	81	10	influenza	influenza	NN
cord-333722-ndth5zne	81	11	is	be	VBZ
cord-333722-ndth5zne	81	12	mediated	mediate	VBN
cord-333722-ndth5zne	81	13	by	by	IN
cord-333722-ndth5zne	81	14	cytokine	cytokine	NN
cord-333722-ndth5zne	81	15	response	response	NN
cord-333722-ndth5zne	81	16	but	but	CC
cord-333722-ndth5zne	81	17	not	not	RB
cord-333722-ndth5zne	81	18	viral	viral	JJ
cord-333722-ndth5zne	81	19	load	load	NN
cord-333722-ndth5zne	81	20	.	.	.
cord-333722-ndth5zne	82	1	Generally	generally	RB
cord-333722-ndth5zne	82	2	,	,	,
cord-333722-ndth5zne	82	3	the	the	DT
cord-333722-ndth5zne	82	4	cytokine	cytokine	NN
cord-333722-ndth5zne	82	5	response	response	NN
cord-333722-ndth5zne	82	6	induced	induce	VBN
cord-333722-ndth5zne	82	7	directly	directly	RB
cord-333722-ndth5zne	82	8	by	by	IN
cord-333722-ndth5zne	82	9	the	the	DT
cord-333722-ndth5zne	82	10	influenza	influenza	NN
cord-333722-ndth5zne	82	11	virus	virus	NN
cord-333722-ndth5zne	82	12	is	be	VBZ
cord-333722-ndth5zne	82	13	a	a	DT
cord-333722-ndth5zne	82	14	sprawling	sprawl	VBG
cord-333722-ndth5zne	82	15	network	network	NN
cord-333722-ndth5zne	82	16	,	,	,
cord-333722-ndth5zne	82	17	which	which	WDT
cord-333722-ndth5zne	82	18	is	be	VBZ
cord-333722-ndth5zne	82	19	amplified	amplify	VBN
cord-333722-ndth5zne	82	20	by	by	IN
cord-333722-ndth5zne	82	21	autocrine	autocrine	NN
cord-333722-ndth5zne	82	22	and	and	CC
cord-333722-ndth5zne	82	23	paracrine	paracrine	JJ
cord-333722-ndth5zne	82	24	mediator	mediator	NN
cord-333722-ndth5zne	82	25	cascades	cascade	NNS
cord-333722-ndth5zne	82	26	.	.	.
cord-333722-ndth5zne	83	1	Pathways	pathway	NNS
cord-333722-ndth5zne	83	2	associated	associate	VBN
cord-333722-ndth5zne	83	3	with	with	IN
cord-333722-ndth5zne	83	4	PRRs	prr	NNS
cord-333722-ndth5zne	83	5	,	,	,
cord-333722-ndth5zne	83	6	ILs	ILs	NNP
cord-333722-ndth5zne	83	7	,	,	,
cord-333722-ndth5zne	83	8	IFNs	IFNs	NNP
cord-333722-ndth5zne	83	9	,	,	,
cord-333722-ndth5zne	83	10	TNFs	TNFs	NNP
cord-333722-ndth5zne	83	11	,	,	,
cord-333722-ndth5zne	83	12	cyclooxygenase	cyclooxygenase	NN
cord-333722-ndth5zne	83	13	(	(	-LRB-
cord-333722-ndth5zne	83	14	COX)-2	COX)-2	NNP
cord-333722-ndth5zne	83	15	,	,	,
cord-333722-ndth5zne	83	16	and	and	CC
cord-333722-ndth5zne	83	17	c	c	LS
cord-333722-ndth5zne	83	18	-	-	:
cord-333722-ndth5zne	83	19	Jun	Jun	NNP
cord-333722-ndth5zne	83	20	N	N	NNP
cord-333722-ndth5zne	83	21	-	-	HYPH
cord-333722-ndth5zne	83	22	terminal	terminal	NN
cord-333722-ndth5zne	83	23	kinase	kinase	NN
cord-333722-ndth5zne	83	24	(	(	-LRB-
cord-333722-ndth5zne	83	25	JNK	JNK	NNP
cord-333722-ndth5zne	83	26	)	)	-RRB-
cord-333722-ndth5zne	83	27	are	be	VBP
cord-333722-ndth5zne	83	28	activated	activate	VBN
cord-333722-ndth5zne	83	29	to	to	TO
cord-333722-ndth5zne	83	30	induce	induce	VB
cord-333722-ndth5zne	83	31	the	the	DT
cord-333722-ndth5zne	83	32	transcription	transcription	NN
cord-333722-ndth5zne	83	33	of	of	IN
cord-333722-ndth5zne	83	34	NF	NF	NNP
cord-333722-ndth5zne	83	35	-	-	HYPH
cord-333722-ndth5zne	83	36	kB	kB	NNP
cord-333722-ndth5zne	83	37	and	and	CC
cord-333722-ndth5zne	83	38	the	the	DT
cord-333722-ndth5zne	83	39	formation	formation	NN
cord-333722-ndth5zne	83	40	of	of	IN
cord-333722-ndth5zne	83	41	inflammasomes	inflammasome	NNS
cord-333722-ndth5zne	83	42	.	.	.
cord-333722-ndth5zne	84	1	7	7	CD
cord-333722-ndth5zne	85	1	A	a	DT
cord-333722-ndth5zne	85	2	cytokine	cytokine	NN
cord-333722-ndth5zne	85	3	/	/	SYM
cord-333722-ndth5zne	85	4	chemokine	chemokine	NN
cord-333722-ndth5zne	85	5	-	-	HYPH
cord-333722-ndth5zne	85	6	driven	drive	VBN
cord-333722-ndth5zne	85	7	feed	feed	NN
cord-333722-ndth5zne	85	8	-	-	HYPH
cord-333722-ndth5zne	85	9	forward	forward	RP
cord-333722-ndth5zne	85	10	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	85	11	circuit	circuit	NN
cord-333722-ndth5zne	85	12	may	may	MD
cord-333722-ndth5zne	85	13	be	be	VB
cord-333722-ndth5zne	85	14	responsible	responsible	JJ
cord-333722-ndth5zne	85	15	for	for	IN
cord-333722-ndth5zne	85	16	the	the	DT
cord-333722-ndth5zne	85	17	escalation	escalation	NN
cord-333722-ndth5zne	85	18	of	of	IN
cord-333722-ndth5zne	85	19	cytokine	cytokine	NN
cord-333722-ndth5zne	85	20	storm	storm	NN
cord-333722-ndth5zne	85	21	.	.	.
cord-333722-ndth5zne	86	1	22	22	CD
cord-333722-ndth5zne	87	1	However	however	RB
cord-333722-ndth5zne	87	2	,	,	,
cord-333722-ndth5zne	87	3	the	the	DT
cord-333722-ndth5zne	87	4	key	key	JJ
cord-333722-ndth5zne	87	5	factors	factor	NNS
cord-333722-ndth5zne	87	6	of	of	IN
cord-333722-ndth5zne	87	7	this	this	DT
cord-333722-ndth5zne	87	8	network	network	NN
cord-333722-ndth5zne	87	9	,	,	,
cord-333722-ndth5zne	87	10	especially	especially	RB
cord-333722-ndth5zne	87	11	those	those	DT
cord-333722-ndth5zne	87	12	specific	specific	JJ
cord-333722-ndth5zne	87	13	to	to	IN
cord-333722-ndth5zne	87	14	the	the	DT
cord-333722-ndth5zne	87	15	pathogenesis	pathogenesis	NN
cord-333722-ndth5zne	87	16	of	of	IN
cord-333722-ndth5zne	87	17	severe	severe	JJ
cord-333722-ndth5zne	87	18	influenza	influenza	NN
cord-333722-ndth5zne	87	19	,	,	,
cord-333722-ndth5zne	87	20	are	be	VBP
cord-333722-ndth5zne	87	21	still	still	RB
cord-333722-ndth5zne	87	22	unknown	unknown	JJ
cord-333722-ndth5zne	87	23	.	.	.
cord-333722-ndth5zne	88	1	By	by	IN
cord-333722-ndth5zne	88	2	using	use	VBG
cord-333722-ndth5zne	88	3	network	network	NN
cord-333722-ndth5zne	88	4	-	-	HYPH
cord-333722-ndth5zne	88	5	based	base	VBN
cord-333722-ndth5zne	88	6	systems	system	NNS
cord-333722-ndth5zne	88	7	biology	biology	NN
cord-333722-ndth5zne	88	8	approaches	approach	NNS
cord-333722-ndth5zne	88	9	,	,	,
cord-333722-ndth5zne	88	10	Jin	Jin	NNP
cord-333722-ndth5zne	88	11	et	et	NNP
cord-333722-ndth5zne	88	12	al	al	NNP
cord-333722-ndth5zne	88	13	.	.	.
cord-333722-ndth5zne	89	1	22	22	CD
cord-333722-ndth5zne	89	2	have	have	VBP
cord-333722-ndth5zne	89	3	made	make	VBN
cord-333722-ndth5zne	89	4	a	a	DT
cord-333722-ndth5zne	89	5	successful	successful	JJ
cord-333722-ndth5zne	89	6	attempt	attempt	NN
cord-333722-ndth5zne	89	7	in	in	IN
cord-333722-ndth5zne	89	8	elucidating	elucidate	VBG
cord-333722-ndth5zne	89	9	the	the	DT
cord-333722-ndth5zne	89	10	network	network	NN
cord-333722-ndth5zne	89	11	properties	property	NNS
cord-333722-ndth5zne	89	12	of	of	IN
cord-333722-ndth5zne	89	13	severe	severe	JJ
cord-333722-ndth5zne	89	14	influenza	influenza	NN
cord-333722-ndth5zne	89	15	.	.	.
cord-333722-ndth5zne	90	1	Their	-PRON-	PRP$
cord-333722-ndth5zne	90	2	study	study	NN
cord-333722-ndth5zne	90	3	demonstrated	demonstrate	VBD
cord-333722-ndth5zne	90	4	that	that	IN
cord-333722-ndth5zne	90	5	TLR2	TLR2	NNP
cord-333722-ndth5zne	90	6	,	,	,
cord-333722-ndth5zne	90	7	IL-1b	IL-1b	NNP
cord-333722-ndth5zne	90	8	,	,	,
cord-333722-ndth5zne	90	9	IL-10	IL-10	NNP
cord-333722-ndth5zne	90	10	,	,	,
cord-333722-ndth5zne	90	11	and	and	CC
cord-333722-ndth5zne	90	12	nuclear	nuclear	JJ
cord-333722-ndth5zne	90	13	factorkappa	factorkappa	NN
cord-333722-ndth5zne	90	14	B	B	NNP
cord-333722-ndth5zne	90	15	have	have	VB
cord-333722-ndth5zne	90	16	obvious	obvious	JJ
cord-333722-ndth5zne	90	17	differences	difference	NNS
cord-333722-ndth5zne	90	18	between	between	IN
cord-333722-ndth5zne	90	19	the	the	DT
cord-333722-ndth5zne	90	20	normal	normal	JJ
cord-333722-ndth5zne	90	21	and	and	CC
cord-333722-ndth5zne	90	22	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	90	23	networks	network	NNS
cord-333722-ndth5zne	90	24	.	.	.
cord-333722-ndth5zne	91	1	22	22	CD
cord-333722-ndth5zne	91	2	Complications	complication	NNS
cord-333722-ndth5zne	91	3	arising	arise	VBG
cord-333722-ndth5zne	91	4	from	from	IN
cord-333722-ndth5zne	91	5	severe	severe	JJ
cord-333722-ndth5zne	91	6	influenza	influenza	NN
cord-333722-ndth5zne	91	7	are	be	VBP
cord-333722-ndth5zne	91	8	associated	associate	VBN
cord-333722-ndth5zne	91	9	with	with	IN
cord-333722-ndth5zne	91	10	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	91	11	cells	cell	NNS
cord-333722-ndth5zne	91	12	.	.	.
cord-333722-ndth5zne	92	1	Monocytes	monocyte	NNS
cord-333722-ndth5zne	92	2	/	/	SYM
cord-333722-ndth5zne	92	3	macrophages	macrophage	NNS
cord-333722-ndth5zne	92	4	are	be	VBP
cord-333722-ndth5zne	92	5	the	the	DT
cord-333722-ndth5zne	92	6	main	main	JJ
cord-333722-ndth5zne	92	7	cells	cell	NNS
cord-333722-ndth5zne	92	8	recruited	recruit	VBN
cord-333722-ndth5zne	92	9	into	into	IN
cord-333722-ndth5zne	92	10	the	the	DT
cord-333722-ndth5zne	92	11	alveolar	alveolar	JJ
cord-333722-ndth5zne	92	12	space	space	NN
cord-333722-ndth5zne	92	13	as	as	IN
cord-333722-ndth5zne	92	14	an	an	DT
cord-333722-ndth5zne	92	15	initial	initial	JJ
cord-333722-ndth5zne	92	16	response	response	NN
cord-333722-ndth5zne	92	17	to	to	IN
cord-333722-ndth5zne	92	18	viral	viral	JJ
cord-333722-ndth5zne	92	19	infection	infection	NN
cord-333722-ndth5zne	92	20	.	.	.
cord-333722-ndth5zne	93	1	3,9	3,9	CD
cord-333722-ndth5zne	94	1	They	-PRON-	PRP
cord-333722-ndth5zne	94	2	then	then	RB
cord-333722-ndth5zne	94	3	increase	increase	VBP
cord-333722-ndth5zne	94	4	their	-PRON-	PRP$
cord-333722-ndth5zne	94	5	cytokine	cytokine	NN
cord-333722-ndth5zne	94	6	production	production	NN
cord-333722-ndth5zne	94	7	and	and	CC
cord-333722-ndth5zne	94	8	chemoattract	chemoattract	VB
cord-333722-ndth5zne	94	9	additional	additional	JJ
cord-333722-ndth5zne	94	10	immune	immune	JJ
cord-333722-ndth5zne	94	11	cells	cell	NNS
cord-333722-ndth5zne	94	12	into	into	IN
cord-333722-ndth5zne	94	13	the	the	DT
cord-333722-ndth5zne	94	14	lesion	lesion	NN
cord-333722-ndth5zne	94	15	area	area	NN
cord-333722-ndth5zne	94	16	.	.	.
cord-333722-ndth5zne	95	1	3,9	3,9	CD
cord-333722-ndth5zne	96	1	Nevertheless	nevertheless	RB
cord-333722-ndth5zne	96	2	,	,	,
cord-333722-ndth5zne	96	3	they	-PRON-	PRP
cord-333722-ndth5zne	96	4	are	be	VBP
cord-333722-ndth5zne	96	5	also	also	RB
cord-333722-ndth5zne	96	6	susceptible	susceptible	JJ
cord-333722-ndth5zne	96	7	to	to	IN
cord-333722-ndth5zne	96	8	influenza	influenza	JJ
cord-333722-ndth5zne	96	9	viral	viral	JJ
cord-333722-ndth5zne	96	10	infection	infection	NN
cord-333722-ndth5zne	96	11	.	.	.
cord-333722-ndth5zne	97	1	Depleting	deplete	VBG
cord-333722-ndth5zne	97	2	the	the	DT
cord-333722-ndth5zne	97	3	monocytes	monocyte	NNS
cord-333722-ndth5zne	97	4	/	/	SYM
cord-333722-ndth5zne	97	5	macrophages	macrophage	NNS
cord-333722-ndth5zne	97	6	does	do	VBZ
cord-333722-ndth5zne	97	7	not	not	RB
cord-333722-ndth5zne	97	8	prevent	prevent	VB
cord-333722-ndth5zne	97	9	immunopathology	immunopathology	NN
cord-333722-ndth5zne	97	10	,	,	,
cord-333722-ndth5zne	97	11	indicating	indicate	VBG
cord-333722-ndth5zne	97	12	their	-PRON-	PRP$
cord-333722-ndth5zne	97	13	important	important	JJ
cord-333722-ndth5zne	97	14	role	role	NN
cord-333722-ndth5zne	97	15	in	in	IN
cord-333722-ndth5zne	97	16	viral	viral	JJ
cord-333722-ndth5zne	97	17	clearance	clearance	NN
cord-333722-ndth5zne	97	18	.	.	.
cord-333722-ndth5zne	98	1	3	3	CD
cord-333722-ndth5zne	98	2	,	,	,
cord-333722-ndth5zne	98	3	9	9	CD
cord-333722-ndth5zne	99	1	Both	both	DT
cord-333722-ndth5zne	99	2	CD4	CD4	NNP
cord-333722-ndth5zne	99	3	and	and	CC
cord-333722-ndth5zne	99	4	CD8	CD8	NNP
cord-333722-ndth5zne	99	5	T	T	NNP
cord-333722-ndth5zne	99	6	cells	cell	NNS
cord-333722-ndth5zne	99	7	are	be	VBP
cord-333722-ndth5zne	99	8	responsible	responsible	JJ
cord-333722-ndth5zne	99	9	for	for	IN
cord-333722-ndth5zne	99	10	the	the	DT
cord-333722-ndth5zne	99	11	immunopathology	immunopathology	NN
cord-333722-ndth5zne	99	12	and	and	CC
cord-333722-ndth5zne	99	13	viral	viral	JJ
cord-333722-ndth5zne	99	14	clearance	clearance	NN
cord-333722-ndth5zne	99	15	of	of	IN
cord-333722-ndth5zne	99	16	infection	infection	NN
cord-333722-ndth5zne	99	17	.	.	.
cord-333722-ndth5zne	100	1	A	a	DT
cord-333722-ndth5zne	100	2	lethal	lethal	JJ
cord-333722-ndth5zne	100	3	lung	lung	NN
cord-333722-ndth5zne	100	4	injury	injury	NN
cord-333722-ndth5zne	100	5	can	can	MD
cord-333722-ndth5zne	100	6	be	be	VB
cord-333722-ndth5zne	100	7	triggered	trigger	VBN
cord-333722-ndth5zne	100	8	by	by	IN
cord-333722-ndth5zne	100	9	the	the	DT
cord-333722-ndth5zne	100	10	transfer	transfer	NN
cord-333722-ndth5zne	100	11	of	of	IN
cord-333722-ndth5zne	100	12	antigen	antigen	NN
cord-333722-ndth5zne	100	13	-	-	HYPH
cord-333722-ndth5zne	100	14	specific	specific	JJ
cord-333722-ndth5zne	100	15	CD8	CD8	NNP
cord-333722-ndth5zne	100	16	T	T	NNP
cord-333722-ndth5zne	100	17	cells	cell	NNS
cord-333722-ndth5zne	100	18	into	into	IN
cord-333722-ndth5zne	100	19	transgenic	transgenic	JJ
cord-333722-ndth5zne	100	20	mice	mouse	NNS
cord-333722-ndth5zne	100	21	expressing	express	VBG
cord-333722-ndth5zne	100	22	the	the	DT
cord-333722-ndth5zne	100	23	influenza	influenza	NN
cord-333722-ndth5zne	100	24	HA	HA	NNP
cord-333722-ndth5zne	100	25	antigen	antigen	NN
cord-333722-ndth5zne	100	26	.	.	.
cord-333722-ndth5zne	101	1	However	however	RB
cord-333722-ndth5zne	101	2	,	,	,
cord-333722-ndth5zne	101	3	a	a	DT
cord-333722-ndth5zne	101	4	lethal	lethal	JJ
cord-333722-ndth5zne	101	5	lung	lung	NN
cord-333722-ndth5zne	101	6	injury	injury	NN
cord-333722-ndth5zne	101	7	can	can	MD
cord-333722-ndth5zne	101	8	not	not	RB
cord-333722-ndth5zne	101	9	be	be	VB
cord-333722-ndth5zne	101	10	triggered	trigger	VBN
cord-333722-ndth5zne	101	11	in	in	IN
cord-333722-ndth5zne	101	12	mice	mouse	NNS
cord-333722-ndth5zne	101	13	with	with	IN
cord-333722-ndth5zne	101	14	defects	defect	NNS
cord-333722-ndth5zne	101	15	in	in	IN
cord-333722-ndth5zne	101	16	the	the	DT
cord-333722-ndth5zne	101	17	epithelial	epithelial	NN
cord-333722-ndth5zne	101	18	early	early	JJ
cord-333722-ndth5zne	101	19	growth	growth	NN
cord-333722-ndth5zne	102	1	response-1	response-1	NNP
cord-333722-ndth5zne	102	2	(	(	-LRB-
cord-333722-ndth5zne	102	3	Egr-1	Egr-1	NNP
cord-333722-ndth5zne	102	4	)	)	-RRB-
cord-333722-ndth5zne	102	5	,	,	,
cord-333722-ndth5zne	102	6	suggesting	suggest	VBG
cord-333722-ndth5zne	102	7	that	that	IN
cord-333722-ndth5zne	102	8	Egr-1	Egr-1	NNP
cord-333722-ndth5zne	102	9	is	be	VBZ
cord-333722-ndth5zne	102	10	a	a	DT
cord-333722-ndth5zne	102	11	critical	critical	JJ
cord-333722-ndth5zne	102	12	regulator	regulator	NN
cord-333722-ndth5zne	102	13	of	of	IN
cord-333722-ndth5zne	102	14	the	the	DT
cord-333722-ndth5zne	102	15	immunopathology	immunopathology	NN
cord-333722-ndth5zne	102	16	of	of	IN
cord-333722-ndth5zne	102	17	CD8	CD8	NNP
cord-333722-ndth5zne	102	18	T	T	NNP
cord-333722-ndth5zne	102	19	cells	cell	NNS
cord-333722-ndth5zne	102	20	.	.	.
cord-333722-ndth5zne	103	1	23	23	CD
cord-333722-ndth5zne	103	2	CD4	CD4	NNP
cord-333722-ndth5zne	103	3	T	T	NNP
cord-333722-ndth5zne	103	4	cells	cell	NNS
cord-333722-ndth5zne	103	5	(	(	-LRB-
cord-333722-ndth5zne	103	6	including	include	VBG
cord-333722-ndth5zne	103	7	Th1	th1	CD
cord-333722-ndth5zne	103	8	,	,	,
cord-333722-ndth5zne	103	9	Th2	th2	CD
cord-333722-ndth5zne	103	10	,	,	,
cord-333722-ndth5zne	103	11	Th17	Th17	NNP
cord-333722-ndth5zne	103	12	,	,	,
cord-333722-ndth5zne	103	13	and	and	CC
cord-333722-ndth5zne	103	14	Treg	Treg	NNP
cord-333722-ndth5zne	103	15	)	)	-RRB-
cord-333722-ndth5zne	103	16	have	have	VBP
cord-333722-ndth5zne	103	17	been	be	VBN
cord-333722-ndth5zne	103	18	identified	identify	VBN
cord-333722-ndth5zne	103	19	to	to	TO
cord-333722-ndth5zne	103	20	contribute	contribute	VB
cord-333722-ndth5zne	103	21	to	to	IN
cord-333722-ndth5zne	103	22	both	both	DT
cord-333722-ndth5zne	103	23	immunopathology	immunopathology	NN
cord-333722-ndth5zne	103	24	and	and	CC
cord-333722-ndth5zne	103	25	viral	viral	JJ
cord-333722-ndth5zne	103	26	clearance	clearance	NN
cord-333722-ndth5zne	103	27	of	of	IN
cord-333722-ndth5zne	103	28	influenza	influenza	NN
cord-333722-ndth5zne	103	29	infection	infection	NN
cord-333722-ndth5zne	103	30	.	.	.
cord-333722-ndth5zne	104	1	Severe	severe	JJ
cord-333722-ndth5zne	104	2	respiratory	respiratory	JJ
cord-333722-ndth5zne	104	3	disease	disease	NN
cord-333722-ndth5zne	104	4	of	of	IN
cord-333722-ndth5zne	104	5	influenza	influenza	NN
cord-333722-ndth5zne	104	6	is	be	VBZ
cord-333722-ndth5zne	104	7	often	often	RB
cord-333722-ndth5zne	104	8	characterized	characterize	VBN
cord-333722-ndth5zne	104	9	by	by	IN
cord-333722-ndth5zne	104	10	the	the	DT
cord-333722-ndth5zne	104	11	early	early	JJ
cord-333722-ndth5zne	104	12	secretion	secretion	NN
cord-333722-ndth5zne	104	13	of	of	IN
cord-333722-ndth5zne	104	14	Th1	th1	NN
cord-333722-ndth5zne	104	15	and	and	CC
cord-333722-ndth5zne	104	16	Th17	th17	CD
cord-333722-ndth5zne	104	17	cytokines	cytokine	NNS
cord-333722-ndth5zne	104	18	.	.	.
cord-333722-ndth5zne	105	1	24	24	CD
cord-333722-ndth5zne	105	2	Tregs	Tregs	NNP
cord-333722-ndth5zne	106	1	(	(	-LRB-
cord-333722-ndth5zne	106	2	regulatory	regulatory	JJ
cord-333722-ndth5zne	106	3	CD4	CD4	NNP
cord-333722-ndth5zne	106	4	(	(	-LRB-
cord-333722-ndth5zne	106	5	1	1	CD
cord-333722-ndth5zne	106	6	)	)	-RRB-
cord-333722-ndth5zne	106	7	Foxp3	foxp3	JJ
cord-333722-ndth5zne	106	8	(	(	-LRB-
cord-333722-ndth5zne	106	9	1	1	CD
cord-333722-ndth5zne	106	10	)	)	-RRB-
cord-333722-ndth5zne	106	11	T	t	NN
cord-333722-ndth5zne	106	12	cells	cell	NNS
cord-333722-ndth5zne	106	13	)	)	-RRB-
cord-333722-ndth5zne	106	14	are	be	VBP
cord-333722-ndth5zne	106	15	key	key	JJ
cord-333722-ndth5zne	106	16	managers	manager	NNS
cord-333722-ndth5zne	106	17	in	in	IN
cord-333722-ndth5zne	106	18	controlling	control	VBG
cord-333722-ndth5zne	106	19	the	the	DT
cord-333722-ndth5zne	106	20	degree	degree	NN
cord-333722-ndth5zne	106	21	of	of	IN
cord-333722-ndth5zne	106	22	cellular	cellular	JJ
cord-333722-ndth5zne	106	23	immune	immune	JJ
cord-333722-ndth5zne	106	24	responses	response	NNS
cord-333722-ndth5zne	106	25	to	to	IN
cord-333722-ndth5zne	106	26	viral	viral	JJ
cord-333722-ndth5zne	106	27	infections	infection	NNS
cord-333722-ndth5zne	106	28	.	.	.
cord-333722-ndth5zne	107	1	Particularly	particularly	RB
cord-333722-ndth5zne	107	2	,	,	,
cord-333722-ndth5zne	107	3	the	the	DT
cord-333722-ndth5zne	107	4	proliferation	proliferation	NN
cord-333722-ndth5zne	107	5	of	of	IN
cord-333722-ndth5zne	107	6	memory	memory	NN
cord-333722-ndth5zne	107	7	CD8(1	cd8(1	NN
cord-333722-ndth5zne	107	8	)	)	-RRB-
cord-333722-ndth5zne	107	9	cells	cell	NNS
cord-333722-ndth5zne	107	10	can	can	MD
cord-333722-ndth5zne	107	11	be	be	VB
cord-333722-ndth5zne	107	12	effectively	effectively	RB
cord-333722-ndth5zne	107	13	controlled	control	VBN
cord-333722-ndth5zne	107	14	by	by	IN
cord-333722-ndth5zne	107	15	the	the	DT
cord-333722-ndth5zne	107	16	memory	memory	NN
cord-333722-ndth5zne	107	17	Tregs	Tregs	NNP
cord-333722-ndth5zne	107	18	in	in	IN
cord-333722-ndth5zne	107	19	an	an	DT
cord-333722-ndth5zne	107	20	Ag	Ag	NNP
cord-333722-ndth5zne	107	21	-	-	HYPH
cord-333722-ndth5zne	107	22	specific	specific	JJ
cord-333722-ndth5zne	107	23	manner	manner	NN
cord-333722-ndth5zne	107	24	that	that	WDT
cord-333722-ndth5zne	107	25	is	be	VBZ
cord-333722-ndth5zne	107	26	MHC	MHC	NNP
cord-333722-ndth5zne	107	27	class	class	NN
cord-333722-ndth5zne	107	28	II	II	NNP
cord-333722-ndth5zne	107	29	dependent	dependent	JJ
cord-333722-ndth5zne	107	30	.	.	.
cord-333722-ndth5zne	108	1	25	25	CD
cord-333722-ndth5zne	109	1	As	as	IN
cord-333722-ndth5zne	109	2	the	the	DT
cord-333722-ndth5zne	109	3	outcome	outcome	NN
cord-333722-ndth5zne	109	4	of	of	IN
cord-333722-ndth5zne	109	5	severe	severe	JJ
cord-333722-ndth5zne	109	6	influenza	influenza	NN
cord-333722-ndth5zne	109	7	is	be	VBZ
cord-333722-ndth5zne	109	8	determined	determine	VBN
cord-333722-ndth5zne	109	9	by	by	IN
cord-333722-ndth5zne	109	10	both	both	DT
cord-333722-ndth5zne	109	11	viral	viral	JJ
cord-333722-ndth5zne	109	12	virulence	virulence	NN
cord-333722-ndth5zne	109	13	and	and	CC
cord-333722-ndth5zne	109	14	host	host	NN
cord-333722-ndth5zne	109	15	resistance	resistance	NN
cord-333722-ndth5zne	109	16	,	,	,
cord-333722-ndth5zne	109	17	the	the	DT
cord-333722-ndth5zne	109	18	use	use	NN
cord-333722-ndth5zne	109	19	of	of	IN
cord-333722-ndth5zne	109	20	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	109	21	therapy	therapy	NN
cord-333722-ndth5zne	109	22	in	in	IN
cord-333722-ndth5zne	109	23	combination	combination	NN
cord-333722-ndth5zne	109	24	with	with	IN
cord-333722-ndth5zne	109	25	conventional	conventional	JJ
cord-333722-ndth5zne	109	26	antiviral	antiviral	JJ
cord-333722-ndth5zne	109	27	therapy	therapy	NN
cord-333722-ndth5zne	109	28	is	be	VBZ
cord-333722-ndth5zne	109	29	highly	highly	RB
cord-333722-ndth5zne	109	30	warranted	warrant	VBN
cord-333722-ndth5zne	109	31	.	.	.
cord-333722-ndth5zne	110	1	In	in	IN
cord-333722-ndth5zne	110	2	fact	fact	NN
cord-333722-ndth5zne	110	3	,	,	,
cord-333722-ndth5zne	110	4	several	several	JJ
cord-333722-ndth5zne	110	5	studies	study	NNS
cord-333722-ndth5zne	110	6	have	have	VBP
cord-333722-ndth5zne	110	7	confirmed	confirm	VBN
cord-333722-ndth5zne	110	8	that	that	IN
cord-333722-ndth5zne	110	9	the	the	DT
cord-333722-ndth5zne	110	10	mortality	mortality	NN
cord-333722-ndth5zne	110	11	and	and	CC
cord-333722-ndth5zne	110	12	organ	organ	NN
cord-333722-ndth5zne	110	13	injury	injury	NN
cord-333722-ndth5zne	110	14	of	of	IN
cord-333722-ndth5zne	110	15	severe	severe	JJ
cord-333722-ndth5zne	110	16	influenza	influenza	NN
cord-333722-ndth5zne	110	17	can	can	MD
cord-333722-ndth5zne	110	18	be	be	VB
cord-333722-ndth5zne	110	19	reduced	reduce	VBN
cord-333722-ndth5zne	110	20	by	by	IN
cord-333722-ndth5zne	110	21	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	110	22	agents	agent	NNS
cord-333722-ndth5zne	110	23	,	,	,
cord-333722-ndth5zne	110	24	with	with	IN
cord-333722-ndth5zne	110	25	or	or	CC
cord-333722-ndth5zne	110	26	without	without	IN
cord-333722-ndth5zne	110	27	the	the	DT
cord-333722-ndth5zne	110	28	combination	combination	NN
cord-333722-ndth5zne	110	29	of	of	IN
cord-333722-ndth5zne	110	30	antivirals	antiviral	NNS
cord-333722-ndth5zne	110	31	.	.	.
cord-333722-ndth5zne	111	1	Moreover	moreover	RB
cord-333722-ndth5zne	111	2	,	,	,
cord-333722-ndth5zne	111	3	many	many	JJ
cord-333722-ndth5zne	111	4	of	of	IN
cord-333722-ndth5zne	111	5	them	-PRON-	PRP
cord-333722-ndth5zne	111	6	are	be	VBP
cord-333722-ndth5zne	111	7	relatively	relatively	RB
cord-333722-ndth5zne	111	8	inexpensive	inexpensive	JJ
cord-333722-ndth5zne	111	9	and	and	CC
cord-333722-ndth5zne	111	10	easily	easily	RB
cord-333722-ndth5zne	111	11	produced	produce	VBN
cord-333722-ndth5zne	111	12	drugs	drug	NNS
cord-333722-ndth5zne	111	13	,	,	,
cord-333722-ndth5zne	111	14	which	which	WDT
cord-333722-ndth5zne	111	15	could	could	MD
cord-333722-ndth5zne	111	16	potentially	potentially	RB
cord-333722-ndth5zne	111	17	be	be	VB
cord-333722-ndth5zne	111	18	widely	widely	RB
cord-333722-ndth5zne	111	19	used	use	VBN
cord-333722-ndth5zne	111	20	in	in	IN
cord-333722-ndth5zne	111	21	an	an	DT
cord-333722-ndth5zne	111	22	influenza	influenza	NN
cord-333722-ndth5zne	111	23	pandemic	pandemic	NN
cord-333722-ndth5zne	111	24	.	.	.
cord-333722-ndth5zne	112	1	Here	here	RB
cord-333722-ndth5zne	112	2	,	,	,
cord-333722-ndth5zne	112	3	we	-PRON-	PRP
cord-333722-ndth5zne	112	4	review	review	VBP
cord-333722-ndth5zne	112	5	the	the	DT
cord-333722-ndth5zne	112	6	properties	property	NNS
cord-333722-ndth5zne	112	7	of	of	IN
cord-333722-ndth5zne	112	8	these	these	DT
cord-333722-ndth5zne	112	9	agents	agent	NNS
cord-333722-ndth5zne	112	10	(	(	-LRB-
cord-333722-ndth5zne	112	11	Table	table	NN
cord-333722-ndth5zne	112	12	1	1	CD
cord-333722-ndth5zne	112	13	)	)	-RRB-
cord-333722-ndth5zne	112	14	.	.	.
cord-333722-ndth5zne	113	1	Corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	113	2	are	be	VBP
cord-333722-ndth5zne	113	3	a	a	DT
cord-333722-ndth5zne	113	4	class	class	NN
cord-333722-ndth5zne	113	5	of	of	IN
cord-333722-ndth5zne	113	6	steroid	steroid	JJ
cord-333722-ndth5zne	113	7	hormones	hormone	NNS
cord-333722-ndth5zne	113	8	that	that	WDT
cord-333722-ndth5zne	113	9	exhibit	exhibit	VBP
cord-333722-ndth5zne	113	10	anti	anti	JJ
cord-333722-ndth5zne	113	11	-	-	JJ
cord-333722-ndth5zne	113	12	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	113	13	activity	activity	NN
cord-333722-ndth5zne	113	14	via	via	IN
cord-333722-ndth5zne	113	15	binding	bind	VBG
cord-333722-ndth5zne	113	16	to	to	IN
cord-333722-ndth5zne	113	17	the	the	DT
cord-333722-ndth5zne	113	18	cytoplasmic	cytoplasmic	JJ
cord-333722-ndth5zne	113	19	corticosteroid	corticosteroid	NN
cord-333722-ndth5zne	113	20	receptor	receptor	NN
cord-333722-ndth5zne	113	21	,	,	,
cord-333722-ndth5zne	113	22	which	which	WDT
cord-333722-ndth5zne	113	23	regulates	regulate	VBZ
cord-333722-ndth5zne	113	24	transcription	transcription	NN
cord-333722-ndth5zne	113	25	of	of	IN
cord-333722-ndth5zne	113	26	antiinflammatory	antiinflammatory	JJ
cord-333722-ndth5zne	113	27	genes	gene	NNS
cord-333722-ndth5zne	113	28	.	.	.
cord-333722-ndth5zne	114	1	26	26	CD
cord-333722-ndth5zne	115	1	Thus	thus	RB
cord-333722-ndth5zne	115	2	,	,	,
cord-333722-ndth5zne	115	3	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	115	4	have	have	VBP
cord-333722-ndth5zne	115	5	been	be	VBN
cord-333722-ndth5zne	115	6	widely	widely	RB
cord-333722-ndth5zne	115	7	used	use	VBN
cord-333722-ndth5zne	115	8	for	for	IN
cord-333722-ndth5zne	115	9	anti	anti	JJ
cord-333722-ndth5zne	115	10	-	-	JJ
cord-333722-ndth5zne	115	11	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	115	12	treatment	treatment	NN
cord-333722-ndth5zne	115	13	.	.	.
cord-333722-ndth5zne	116	1	During	during	IN
cord-333722-ndth5zne	116	2	the	the	DT
cord-333722-ndth5zne	116	3	2009	2009	CD
cord-333722-ndth5zne	116	4	H1N1	H1N1	NNP
cord-333722-ndth5zne	116	5	influenza	influenza	NN
cord-333722-ndth5zne	116	6	pandemic	pandemic	NN
cord-333722-ndth5zne	116	7	,	,	,
cord-333722-ndth5zne	116	8	nearly	nearly	RB
cord-333722-ndth5zne	116	9	40	40	CD
cord-333722-ndth5zne	116	10	%	%	NN
cord-333722-ndth5zne	116	11	of	of	IN
cord-333722-ndth5zne	116	12	patients	patient	NNS
cord-333722-ndth5zne	116	13	in	in	IN
cord-333722-ndth5zne	116	14	France	France	NNP
cord-333722-ndth5zne	116	15	were	be	VBD
cord-333722-ndth5zne	116	16	treated	treat	VBN
cord-333722-ndth5zne	116	17	for	for	IN
cord-333722-ndth5zne	116	18	acute	acute	JJ
cord-333722-ndth5zne	116	19	respiratory	respiratory	JJ
cord-333722-ndth5zne	116	20	distress	distress	NN
cord-333722-ndth5zne	116	21	syndrome	syndrome	NN
cord-333722-ndth5zne	116	22	(	(	-LRB-
cord-333722-ndth5zne	116	23	ARDS	ARDS	NNP
cord-333722-ndth5zne	116	24	)	)	-RRB-
cord-333722-ndth5zne	116	25	using	use	VBG
cord-333722-ndth5zne	116	26	adjuvant	adjuvant	JJ
cord-333722-ndth5zne	116	27	systemic	systemic	JJ
cord-333722-ndth5zne	116	28	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	116	29	.	.	.
cord-333722-ndth5zne	117	1	27	27	CD
cord-333722-ndth5zne	118	1	During	during	IN
cord-333722-ndth5zne	118	2	the	the	DT
cord-333722-ndth5zne	118	3	2013	2013	CD
cord-333722-ndth5zne	118	4	H7N9	H7N9	NNP
cord-333722-ndth5zne	118	5	avian	avian	JJ
cord-333722-ndth5zne	118	6	influenza	influenza	NN
cord-333722-ndth5zne	118	7	outbreak	outbreak	NN
cord-333722-ndth5zne	118	8	in	in	IN
cord-333722-ndth5zne	118	9	China	China	NNP
cord-333722-ndth5zne	118	10	,	,	,
cord-333722-ndth5zne	118	11	62.2	62.2	CD
cord-333722-ndth5zne	118	12	%	%	NN
cord-333722-ndth5zne	118	13	of	of	IN
cord-333722-ndth5zne	118	14	patients	patient	NNS
cord-333722-ndth5zne	118	15	received	receive	VBD
cord-333722-ndth5zne	118	16	systemic	systemic	JJ
cord-333722-ndth5zne	118	17	corticosteroid	corticosteroid	JJ
cord-333722-ndth5zne	118	18	treatment	treatment	NN
cord-333722-ndth5zne	118	19	.	.	.
cord-333722-ndth5zne	119	1	28	28	CD
cord-333722-ndth5zne	120	1	However	however	RB
cord-333722-ndth5zne	120	2	,	,	,
cord-333722-ndth5zne	120	3	the	the	DT
cord-333722-ndth5zne	120	4	evidence	evidence	NN
cord-333722-ndth5zne	120	5	supporting	support	VBG
cord-333722-ndth5zne	120	6	the	the	DT
cord-333722-ndth5zne	120	7	use	use	NN
cord-333722-ndth5zne	120	8	of	of	IN
cord-333722-ndth5zne	120	9	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	120	10	in	in	IN
cord-333722-ndth5zne	120	11	severe	severe	JJ
cord-333722-ndth5zne	120	12	influenza	influenza	NN
cord-333722-ndth5zne	120	13	is	be	VBZ
cord-333722-ndth5zne	120	14	inconclusive	inconclusive	JJ
cord-333722-ndth5zne	120	15	.	.	.
cord-333722-ndth5zne	121	1	An	an	DT
cord-333722-ndth5zne	121	2	experimental	experimental	JJ
cord-333722-ndth5zne	121	3	study	study	NN
cord-333722-ndth5zne	121	4	has	have	VBZ
cord-333722-ndth5zne	121	5	shown	show	VBN
cord-333722-ndth5zne	121	6	that	that	IN
cord-333722-ndth5zne	121	7	mice	mouse	NNS
cord-333722-ndth5zne	121	8	infected	infect	VBN
cord-333722-ndth5zne	121	9	with	with	IN
cord-333722-ndth5zne	121	10	H5N1	H5N1	NNP
cord-333722-ndth5zne	121	11	influenza	influenza	NN
cord-333722-ndth5zne	121	12	have	have	VBP
cord-333722-ndth5zne	121	13	a	a	DT
cord-333722-ndth5zne	121	14	similar	similar	JJ
cord-333722-ndth5zne	121	15	mortality	mortality	NN
cord-333722-ndth5zne	121	16	between	between	IN
cord-333722-ndth5zne	121	17	the	the	DT
cord-333722-ndth5zne	121	18	corticosteroid	corticosteroid	NN
cord-333722-ndth5zne	121	19	-	-	HYPH
cord-333722-ndth5zne	121	20	treated	treat	VBN
cord-333722-ndth5zne	121	21	group	group	NN
cord-333722-ndth5zne	121	22	and	and	CC
cord-333722-ndth5zne	121	23	the	the	DT
cord-333722-ndth5zne	121	24	control	control	NN
cord-333722-ndth5zne	121	25	group	group	NN
cord-333722-ndth5zne	121	26	.	.	.
cord-333722-ndth5zne	122	1	29	29	CD
cord-333722-ndth5zne	123	1	A	a	DT
cord-333722-ndth5zne	123	2	clinical	clinical	JJ
cord-333722-ndth5zne	123	3	trial	trial	NN
cord-333722-ndth5zne	123	4	even	even	RB
cord-333722-ndth5zne	123	5	identified	identify	VBD
cord-333722-ndth5zne	123	6	that	that	IN
cord-333722-ndth5zne	123	7	systemic	systemic	JJ
cord-333722-ndth5zne	123	8	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	123	9	were	be	VBD
cord-333722-ndth5zne	123	10	responsible	responsible	JJ
cord-333722-ndth5zne	123	11	for	for	IN
cord-333722-ndth5zne	123	12	an	an	DT
cord-333722-ndth5zne	123	13	increased	increased	JJ
cord-333722-ndth5zne	123	14	long	long	JJ
cord-333722-ndth5zne	123	15	-	-	HYPH
cord-333722-ndth5zne	123	16	term	term	NN
cord-333722-ndth5zne	123	17	mortality	mortality	NN
cord-333722-ndth5zne	123	18	.	.	.
cord-333722-ndth5zne	124	1	27	27	CD
cord-333722-ndth5zne	125	1	In	in	IN
cord-333722-ndth5zne	125	2	contrast	contrast	NN
cord-333722-ndth5zne	125	3	,	,	,
cord-333722-ndth5zne	125	4	another	another	DT
cord-333722-ndth5zne	125	5	independent	independent	JJ
cord-333722-ndth5zne	125	6	research	research	NN
cord-333722-ndth5zne	125	7	study	study	NN
cord-333722-ndth5zne	125	8	reported	report	VBD
cord-333722-ndth5zne	125	9	that	that	IN
cord-333722-ndth5zne	125	10	systemic	systemic	JJ
cord-333722-ndth5zne	125	11	use	use	NN
cord-333722-ndth5zne	125	12	of	of	IN
cord-333722-ndth5zne	125	13	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	125	14	alleviated	alleviate	VBD
cord-333722-ndth5zne	125	15	the	the	DT
cord-333722-ndth5zne	125	16	2009	2009	CD
cord-333722-ndth5zne	125	17	H1N1	H1N1	NNP
cord-333722-ndth5zne	125	18	pandemic	pandemic	NN
cord-333722-ndth5zne	125	19	influenza	influenza	NN
cord-333722-ndth5zne	125	20	-	-	HYPH
cord-333722-ndth5zne	125	21	associated	associate	VBN
cord-333722-ndth5zne	125	22	pneumonia	pneumonia	NN
cord-333722-ndth5zne	125	23	without	without	IN
cord-333722-ndth5zne	125	24	adverse	adverse	JJ
cord-333722-ndth5zne	125	25	outcomes	outcome	NNS
cord-333722-ndth5zne	125	26	.	.	.
cord-333722-ndth5zne	126	1	30	30	CD
cord-333722-ndth5zne	127	1	Thus	thus	RB
cord-333722-ndth5zne	127	2	,	,	,
cord-333722-ndth5zne	127	3	the	the	DT
cord-333722-ndth5zne	127	4	use	use	NN
cord-333722-ndth5zne	127	5	of	of	IN
cord-333722-ndth5zne	127	6	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	127	7	for	for	IN
cord-333722-ndth5zne	127	8	severe	severe	JJ
cord-333722-ndth5zne	127	9	influenza	influenza	NN
cord-333722-ndth5zne	127	10	is	be	VBZ
cord-333722-ndth5zne	127	11	controversial	controversial	JJ
cord-333722-ndth5zne	127	12	and	and	CC
cord-333722-ndth5zne	127	13	still	still	RB
cord-333722-ndth5zne	127	14	needs	need	VBZ
cord-333722-ndth5zne	127	15	further	further	JJ
cord-333722-ndth5zne	127	16	observations	observation	NNS
cord-333722-ndth5zne	127	17	.	.	.
cord-333722-ndth5zne	128	1	Peroxisome	Peroxisome	NNP
cord-333722-ndth5zne	128	2	proliferator	proliferator	NN
cord-333722-ndth5zne	128	3	-	-	HYPH
cord-333722-ndth5zne	128	4	activated	activate	VBN
cord-333722-ndth5zne	128	5	receptors	receptor	NNS
cord-333722-ndth5zne	128	6	(	(	-LRB-
cord-333722-ndth5zne	128	7	PPARs	ppar	NNS
cord-333722-ndth5zne	128	8	)	)	-RRB-
cord-333722-ndth5zne	128	9	,	,	,
cord-333722-ndth5zne	128	10	including	include	VBG
cord-333722-ndth5zne	128	11	PPAR	PPAR	NNP
cord-333722-ndth5zne	128	12	-	-	:
cord-333722-ndth5zne	128	13	a	a	DT
cord-333722-ndth5zne	128	14	,	,	,
cord-333722-ndth5zne	128	15	PPAR	PPAR	NNP
cord-333722-ndth5zne	128	16	-	-	HYPH
cord-333722-ndth5zne	128	17	b	b	NN
cord-333722-ndth5zne	128	18	,	,	,
cord-333722-ndth5zne	128	19	and	and	CC
cord-333722-ndth5zne	128	20	PPAR	PPAR	NNP
cord-333722-ndth5zne	128	21	-	-	HYPH
cord-333722-ndth5zne	128	22	c	c	NNP
cord-333722-ndth5zne	128	23	,	,	,
cord-333722-ndth5zne	128	24	are	be	VBP
cord-333722-ndth5zne	128	25	critical	critical	JJ
cord-333722-ndth5zne	128	26	regulators	regulator	NNS
cord-333722-ndth5zne	128	27	of	of	IN
cord-333722-ndth5zne	128	28	inflammation	inflammation	NN
cord-333722-ndth5zne	128	29	.	.	.
cord-333722-ndth5zne	129	1	The	the	DT
cord-333722-ndth5zne	129	2	PPAR	PPAR	NNP
cord-333722-ndth5zne	129	3	-	-	:
cord-333722-ndth5zne	129	4	a	a	DT
cord-333722-ndth5zne	129	5	agonist	agonist	NN
cord-333722-ndth5zne	129	6	,	,	,
cord-333722-ndth5zne	129	7	gemfibrozil	gemfibrozil	NN
cord-333722-ndth5zne	129	8	,	,	,
cord-333722-ndth5zne	129	9	has	have	VBZ
cord-333722-ndth5zne	129	10	been	be	VBN
cord-333722-ndth5zne	129	11	proposed	propose	VBN
cord-333722-ndth5zne	129	12	to	to	TO
cord-333722-ndth5zne	129	13	treat	treat	VB
cord-333722-ndth5zne	129	14	severe	severe	JJ
cord-333722-ndth5zne	129	15	influenza	influenza	NN
cord-333722-ndth5zne	129	16	due	due	IN
cord-333722-ndth5zne	129	17	to	to	IN
cord-333722-ndth5zne	129	18	ability	ability	NN
cord-333722-ndth5zne	129	19	to	to	TO
cord-333722-ndth5zne	129	20	inhibit	inhibit	VB
cord-333722-ndth5zne	129	21	TNF	TNF	NNP
cord-333722-ndth5zne	129	22	,	,	,
cord-333722-ndth5zne	129	23	IL-6	IL-6	NNP
cord-333722-ndth5zne	129	24	,	,	,
cord-333722-ndth5zne	129	25	and	and	CC
cord-333722-ndth5zne	129	26	IFN	IFN	NNP
cord-333722-ndth5zne	129	27	-	-	HYPH
cord-333722-ndth5zne	129	28	c	c	NNP
cord-333722-ndth5zne	129	29	.	.	.
cord-333722-ndth5zne	130	1	31	31	CD
cord-333722-ndth5zne	131	1	However	however	RB
cord-333722-ndth5zne	131	2	,	,	,
cord-333722-ndth5zne	131	3	another	another	DT
cord-333722-ndth5zne	131	4	research	research	NN
cord-333722-ndth5zne	131	5	study	study	NN
cord-333722-ndth5zne	131	6	32	32	CD
cord-333722-ndth5zne	131	7	reported	report	VBD
cord-333722-ndth5zne	131	8	that	that	IN
cord-333722-ndth5zne	131	9	gemfibrozil	gemfibrozil	NN
cord-333722-ndth5zne	131	10	administered	administer	VBN
cord-333722-ndth5zne	132	1	48-h	48-h	LS
cord-333722-ndth5zne	132	2	post	post	JJ
cord-333722-ndth5zne	132	3	-	-	NN
cord-333722-ndth5zne	132	4	infection	infection	NN
cord-333722-ndth5zne	132	5	had	have	VBD
cord-333722-ndth5zne	132	6	no	no	DT
cord-333722-ndth5zne	132	7	effects	effect	NNS
cord-333722-ndth5zne	132	8	on	on	IN
cord-333722-ndth5zne	132	9	the	the	DT
cord-333722-ndth5zne	132	10	mortality	mortality	NN
cord-333722-ndth5zne	132	11	of	of	IN
cord-333722-ndth5zne	132	12	H5N1	H5N1	NNP
cord-333722-ndth5zne	132	13	avian	avian	JJ
cord-333722-ndth5zne	132	14	influenza	influenza	NN
cord-333722-ndth5zne	132	15	-	-	HYPH
cord-333722-ndth5zne	132	16	infected	infect	VBN
cord-333722-ndth5zne	132	17	mice	mouse	NNS
cord-333722-ndth5zne	132	18	.	.	.
cord-333722-ndth5zne	133	1	This	this	DT
cord-333722-ndth5zne	133	2	suggests	suggest	VBZ
cord-333722-ndth5zne	133	3	that	that	IN
cord-333722-ndth5zne	133	4	the	the	DT
cord-333722-ndth5zne	133	5	pharmacological	pharmacological	JJ
cord-333722-ndth5zne	133	6	mechanism	mechanism	NN
cord-333722-ndth5zne	133	7	of	of	IN
cord-333722-ndth5zne	133	8	gemfibrozil	gemfibrozil	NN
cord-333722-ndth5zne	133	9	to	to	TO
cord-333722-ndth5zne	133	10	treat	treat	VB
cord-333722-ndth5zne	133	11	severe	severe	JJ
cord-333722-ndth5zne	133	12	influenza	influenza	NN
cord-333722-ndth5zne	133	13	still	still	RB
cord-333722-ndth5zne	133	14	needs	need	VBZ
cord-333722-ndth5zne	133	15	further	further	JJ
cord-333722-ndth5zne	133	16	characterization	characterization	NN
cord-333722-ndth5zne	133	17	.	.	.
cord-333722-ndth5zne	134	1	There	there	EX
cord-333722-ndth5zne	134	2	is	be	VBZ
cord-333722-ndth5zne	134	3	little	little	JJ
cord-333722-ndth5zne	134	4	research	research	NN
cord-333722-ndth5zne	134	5	on	on	IN
cord-333722-ndth5zne	134	6	the	the	DT
cord-333722-ndth5zne	134	7	use	use	NN
cord-333722-ndth5zne	134	8	of	of	IN
cord-333722-ndth5zne	134	9	PPAR	PPAR	NNP
cord-333722-ndth5zne	134	10	-	-	HYPH
cord-333722-ndth5zne	134	11	b	b	NN
cord-333722-ndth5zne	134	12	agonists	agonist	NNS
cord-333722-ndth5zne	134	13	to	to	TO
cord-333722-ndth5zne	134	14	treat	treat	VB
cord-333722-ndth5zne	134	15	severe	severe	JJ
cord-333722-ndth5zne	134	16	influenza	influenza	NN
cord-333722-ndth5zne	134	17	,	,	,
cord-333722-ndth5zne	134	18	perhaps	perhaps	RB
cord-333722-ndth5zne	134	19	focusing	focus	VBG
cord-333722-ndth5zne	134	20	on	on	IN
cord-333722-ndth5zne	134	21	their	-PRON-	PRP$
cord-333722-ndth5zne	134	22	trophic	trophic	JJ
cord-333722-ndth5zne	134	23	effects	effect	NNS
cord-333722-ndth5zne	134	24	on	on	IN
cord-333722-ndth5zne	134	25	oligodendrocytes	oligodendrocyte	NNS
cord-333722-ndth5zne	134	26	in	in	IN
cord-333722-ndth5zne	134	27	vitro	vitro	FW
cord-333722-ndth5zne	134	28	.	.	.
cord-333722-ndth5zne	135	1	Only	only	RB
cord-333722-ndth5zne	135	2	bezafibrate	bezafibrate	NNP
cord-333722-ndth5zne	135	3	was	be	VBD
cord-333722-ndth5zne	135	4	shown	show	VBN
cord-333722-ndth5zne	135	5	to	to	TO
cord-333722-ndth5zne	135	6	have	have	VB
cord-333722-ndth5zne	135	7	partial	partial	JJ
cord-333722-ndth5zne	135	8	protection	protection	NN
cord-333722-ndth5zne	135	9	in	in	IN
cord-333722-ndth5zne	135	10	patients	patient	NNS
cord-333722-ndth5zne	135	11	with	with	IN
cord-333722-ndth5zne	135	12	influenza	influenza	NN
cord-333722-ndth5zne	135	13	-	-	HYPH
cord-333722-ndth5zne	135	14	associated	associate	VBN
cord-333722-ndth5zne	135	15	encephalopathy	encephalopathy	NN
cord-333722-ndth5zne	135	16	.	.	.
cord-333722-ndth5zne	136	1	33	33	CD
cord-333722-ndth5zne	137	1	However	however	RB
cord-333722-ndth5zne	137	2	,	,	,
cord-333722-ndth5zne	137	3	PPAR	PPAR	NNP
cord-333722-ndth5zne	137	4	-	-	HYPH
cord-333722-ndth5zne	137	5	c	c	NN
cord-333722-ndth5zne	137	6	agonists	agonist	NNS
cord-333722-ndth5zne	137	7	(	(	-LRB-
cord-333722-ndth5zne	137	8	e.g.	e.g.	RB
cord-333722-ndth5zne	137	9	,	,	,
cord-333722-ndth5zne	137	10	rosiglitazone	rosiglitazone	NN
cord-333722-ndth5zne	137	11	and	and	CC
cord-333722-ndth5zne	137	12	pioglitazone	pioglitazone	NN
cord-333722-ndth5zne	137	13	)	)	-RRB-
cord-333722-ndth5zne	137	14	are	be	VBP
cord-333722-ndth5zne	137	15	considered	consider	VBN
cord-333722-ndth5zne	137	16	to	to	TO
cord-333722-ndth5zne	137	17	be	be	VB
cord-333722-ndth5zne	137	18	the	the	DT
cord-333722-ndth5zne	137	19	most	most	RBS
cord-333722-ndth5zne	137	20	promising	promising	JJ
cord-333722-ndth5zne	137	21	candidates	candidate	NNS
cord-333722-ndth5zne	137	22	to	to	TO
cord-333722-ndth5zne	137	23	improve	improve	VB
cord-333722-ndth5zne	137	24	the	the	DT
cord-333722-ndth5zne	137	25	clinical	clinical	JJ
cord-333722-ndth5zne	137	26	outcome	outcome	NN
cord-333722-ndth5zne	137	27	of	of	IN
cord-333722-ndth5zne	137	28	severe	severe	JJ
cord-333722-ndth5zne	137	29	influenza	influenza	NN
cord-333722-ndth5zne	137	30	.	.	.
cord-333722-ndth5zne	138	1	26	26	CD
cord-333722-ndth5zne	139	1	These	these	DT
cord-333722-ndth5zne	139	2	thiazolidinediones	thiazolidinedione	NNS
cord-333722-ndth5zne	139	3	can	can	MD
cord-333722-ndth5zne	139	4	not	not	RB
cord-333722-ndth5zne	139	5	only	only	RB
cord-333722-ndth5zne	139	6	downregulate	downregulate	VB
cord-333722-ndth5zne	139	7	the	the	DT
cord-333722-ndth5zne	139	8	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	139	9	response	response	NN
cord-333722-ndth5zne	139	10	to	to	IN
cord-333722-ndth5zne	139	11	viral	viral	JJ
cord-333722-ndth5zne	139	12	pneumonia	pneumonia	NN
cord-333722-ndth5zne	139	13	but	but	CC
cord-333722-ndth5zne	139	14	also	also	RB
cord-333722-ndth5zne	139	15	increase	increase	VB
cord-333722-ndth5zne	139	16	the	the	DT
cord-333722-ndth5zne	139	17	survival	survival	NN
cord-333722-ndth5zne	139	18	of	of	IN
cord-333722-ndth5zne	139	19	influenza	influenza	NN
cord-333722-ndth5zne	139	20	-	-	HYPH
cord-333722-ndth5zne	139	21	infected	infect	VBN
cord-333722-ndth5zne	139	22	mice	mouse	NNS
cord-333722-ndth5zne	139	23	.	.	.
cord-333722-ndth5zne	140	1	34	34	CD
cord-333722-ndth5zne	141	1	Moreover	moreover	RB
cord-333722-ndth5zne	141	2	,	,	,
cord-333722-ndth5zne	141	3	the	the	DT
cord-333722-ndth5zne	141	4	benefits	benefit	NNS
cord-333722-ndth5zne	141	5	of	of	IN
cord-333722-ndth5zne	141	6	PPAR	PPAR	NNP
cord-333722-ndth5zne	141	7	-	-	HYPH
cord-333722-ndth5zne	141	8	c	c	NN
cord-333722-ndth5zne	141	9	agonist	agonist	NN
cord-333722-ndth5zne	141	10	treatment	treatment	NN
cord-333722-ndth5zne	141	11	were	be	VBD
cord-333722-ndth5zne	141	12	found	find	VBN
cord-333722-ndth5zne	141	13	to	to	TO
cord-333722-ndth5zne	141	14	be	be	VB
cord-333722-ndth5zne	141	15	higher	high	JJR
cord-333722-ndth5zne	141	16	than	than	IN
cord-333722-ndth5zne	141	17	gemfibrozil	gemfibrozil	NN
cord-333722-ndth5zne	141	18	.	.	.
cord-333722-ndth5zne	142	1	26	26	CD
cord-333722-ndth5zne	143	1	In	in	IN
cord-333722-ndth5zne	143	2	addition	addition	NN
cord-333722-ndth5zne	143	3	,	,	,
cord-333722-ndth5zne	143	4	a	a	DT
cord-333722-ndth5zne	143	5	natural	natural	JJ
cord-333722-ndth5zne	143	6	PPAR	PPAR	NNP
cord-333722-ndth5zne	143	7	-	-	:
cord-333722-ndth5zne	143	8	a	a	NN
cord-333722-ndth5zne	143	9	and	and	CC
cord-333722-ndth5zne	143	10	PPAR	PPAR	NNP
cord-333722-ndth5zne	143	11	-	-	HYPH
cord-333722-ndth5zne	143	12	c	c	NN
cord-333722-ndth5zne	143	13	agonist	agonist	NN
cord-333722-ndth5zne	143	14	,	,	,
cord-333722-ndth5zne	143	15	biochanin	biochanin	NNP
cord-333722-ndth5zne	143	16	A	A	NNP
cord-333722-ndth5zne	143	17	,	,	,
cord-333722-ndth5zne	143	18	which	which	WDT
cord-333722-ndth5zne	143	19	is	be	VBZ
cord-333722-ndth5zne	143	20	extracted	extract	VBN
cord-333722-ndth5zne	143	21	from	from	IN
cord-333722-ndth5zne	143	22	red	red	JJ
cord-333722-ndth5zne	143	23	clover	clover	NN
cord-333722-ndth5zne	143	24	,	,	,
cord-333722-ndth5zne	143	25	has	have	VBZ
cord-333722-ndth5zne	143	26	been	be	VBN
cord-333722-ndth5zne	143	27	confirmed	confirm	VBN
cord-333722-ndth5zne	143	28	to	to	TO
cord-333722-ndth5zne	143	29	have	have	VB
cord-333722-ndth5zne	143	30	similar	similar	JJ
cord-333722-ndth5zne	143	31	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	143	32	effects	effect	NNS
cord-333722-ndth5zne	143	33	as	as	IN
cord-333722-ndth5zne	143	34	gemfibrozil	gemfibrozil	NN
cord-333722-ndth5zne	143	35	for	for	IN
cord-333722-ndth5zne	143	36	the	the	DT
cord-333722-ndth5zne	143	37	treatment	treatment	NN
cord-333722-ndth5zne	143	38	of	of	IN
cord-333722-ndth5zne	143	39	influenza	influenza	NN
cord-333722-ndth5zne	143	40	in	in	IN
cord-333722-ndth5zne	143	41	vivo	vivo	NNP
cord-333722-ndth5zne	143	42	.	.	.
cord-333722-ndth5zne	144	1	35	35	CD
cord-333722-ndth5zne	144	2	3.3	3.3	CD
cord-333722-ndth5zne	144	3	.	.	.
cord-333722-ndth5zne	145	1	Sphingosine-1-phosphate	Sphingosine-1-phosphate	NNP
cord-333722-ndth5zne	145	2	receptor	receptor	NN
cord-333722-ndth5zne	145	3	1	1	CD
cord-333722-ndth5zne	145	4	agonists	agonist	NNS
cord-333722-ndth5zne	146	1	In	in	IN
cord-333722-ndth5zne	146	2	recent	recent	JJ
cord-333722-ndth5zne	146	3	years	year	NNS
cord-333722-ndth5zne	146	4	,	,	,
cord-333722-ndth5zne	146	5	there	there	EX
cord-333722-ndth5zne	146	6	has	have	VBZ
cord-333722-ndth5zne	146	7	been	be	VBN
cord-333722-ndth5zne	146	8	an	an	DT
cord-333722-ndth5zne	146	9	increasing	increase	VBG
cord-333722-ndth5zne	146	10	interest	interest	NN
cord-333722-ndth5zne	146	11	in	in	IN
cord-333722-ndth5zne	146	12	developing	develop	VBG
cord-333722-ndth5zne	146	13	novel	novel	JJ
cord-333722-ndth5zne	146	14	agents	agent	NNS
cord-333722-ndth5zne	146	15	with	with	IN
cord-333722-ndth5zne	146	16	anti	anti	JJ
cord-333722-ndth5zne	146	17	-	-	JJ
cord-333722-ndth5zne	146	18	immunopathologic	immunopathologic	JJ
cord-333722-ndth5zne	146	19	injury	injury	NN
cord-333722-ndth5zne	146	20	activity	activity	NN
cord-333722-ndth5zne	146	21	through	through	IN
cord-333722-ndth5zne	146	22	the	the	DT
cord-333722-ndth5zne	146	23	sphingosine-1-phosphate	sphingosine-1-phosphate	NNP
cord-333722-ndth5zne	146	24	(	(	-LRB-
cord-333722-ndth5zne	146	25	S1P	s1p	NN
cord-333722-ndth5zne	146	26	)	)	-RRB-
cord-333722-ndth5zne	146	27	receptor	receptor	NN
cord-333722-ndth5zne	146	28	pathway	pathway	NN
cord-333722-ndth5zne	146	29	.	.	.
cord-333722-ndth5zne	147	1	36	36	CD
cord-333722-ndth5zne	147	2	Five	five	CD
cord-333722-ndth5zne	147	3	specific	specific	JJ
cord-333722-ndth5zne	147	4	S1P	s1p	NN
cord-333722-ndth5zne	147	5	receptors	receptor	NNS
cord-333722-ndth5zne	147	6	have	have	VBP
cord-333722-ndth5zne	147	7	been	be	VBN
cord-333722-ndth5zne	147	8	found	find	VBN
cord-333722-ndth5zne	147	9	to	to	TO
cord-333722-ndth5zne	147	10	regulate	regulate	VB
cord-333722-ndth5zne	147	11	downstream	downstream	JJ
cord-333722-ndth5zne	147	12	signaling	signal	VBG
cord-333722-ndth5zne	147	13	pathways	pathway	NNS
cord-333722-ndth5zne	147	14	.	.	.
cord-333722-ndth5zne	148	1	However	however	RB
cord-333722-ndth5zne	148	2	,	,	,
cord-333722-ndth5zne	148	3	only	only	RB
cord-333722-ndth5zne	148	4	S1P1	S1P1	NNP
cord-333722-ndth5zne	148	5	,	,	,
cord-333722-ndth5zne	148	6	which	which	WDT
cord-333722-ndth5zne	148	7	is	be	VBZ
cord-333722-ndth5zne	148	8	located	locate	VBN
cord-333722-ndth5zne	148	9	mainly	mainly	RB
cord-333722-ndth5zne	148	10	on	on	IN
cord-333722-ndth5zne	148	11	pulmonary	pulmonary	JJ
cord-333722-ndth5zne	148	12	endothelial	endothelial	JJ
cord-333722-ndth5zne	148	13	cells	cell	NNS
cord-333722-ndth5zne	148	14	,	,	,
cord-333722-ndth5zne	148	15	exhibits	exhibit	VBZ
cord-333722-ndth5zne	148	16	cytokine	cytokine	NN
cord-333722-ndth5zne	148	17	-	-	HYPH
cord-333722-ndth5zne	148	18	storm	storm	NN
cord-333722-ndth5zne	148	19	-	-	HYPH
cord-333722-ndth5zne	148	20	blunting	blunt	VBG
cord-333722-ndth5zne	148	21	activity	activity	NN
cord-333722-ndth5zne	148	22	by	by	IN
cord-333722-ndth5zne	148	23	suppressing	suppress	VBG
cord-333722-ndth5zne	148	24	both	both	DT
cord-333722-ndth5zne	148	25	innate	innate	JJ
cord-333722-ndth5zne	148	26	cellular	cellular	JJ
cord-333722-ndth5zne	148	27	and	and	CC
cord-333722-ndth5zne	148	28	cytokine	cytokine	NN
cord-333722-ndth5zne	148	29	/	/	SYM
cord-333722-ndth5zne	148	30	chemokine	chemokine	NN
cord-333722-ndth5zne	148	31	responses	response	NNS
cord-333722-ndth5zne	148	32	.	.	.
cord-333722-ndth5zne	149	1	36	36	CD
cord-333722-ndth5zne	150	1	For	for	IN
cord-333722-ndth5zne	150	2	example	example	NN
cord-333722-ndth5zne	150	3	,	,	,
cord-333722-ndth5zne	150	4	CYM-5442	CYM-5442	NNP
cord-333722-ndth5zne	150	5	and	and	CC
cord-333722-ndth5zne	150	6	RP-002	RP-002	NNP
cord-333722-ndth5zne	150	7	have	have	VBP
cord-333722-ndth5zne	150	8	been	be	VBN
cord-333722-ndth5zne	150	9	reported	report	VBN
cord-333722-ndth5zne	150	10	to	to	TO
cord-333722-ndth5zne	150	11	protect	protect	VB
cord-333722-ndth5zne	150	12	mice	mouse	NNS
cord-333722-ndth5zne	150	13	from	from	IN
cord-333722-ndth5zne	150	14	lethal	lethal	JJ
cord-333722-ndth5zne	150	15	infection	infection	NN
cord-333722-ndth5zne	150	16	with	with	IN
cord-333722-ndth5zne	150	17	severe	severe	JJ
cord-333722-ndth5zne	150	18	influenza	influenza	NN
cord-333722-ndth5zne	150	19	by	by	IN
cord-333722-ndth5zne	150	20	blunting	blunt	VBG
cord-333722-ndth5zne	150	21	cytokines	cytokine	NNS
cord-333722-ndth5zne	150	22	and	and	CC
cord-333722-ndth5zne	150	23	innate	innate	JJ
cord-333722-ndth5zne	150	24	immune	immune	JJ
cord-333722-ndth5zne	150	25	cell	cell	NN
cord-333722-ndth5zne	150	26	recruitment	recruitment	NN
cord-333722-ndth5zne	150	27	.	.	.
cord-333722-ndth5zne	151	1	8	8	CD
cord-333722-ndth5zne	152	1	Particularly	particularly	RB
cord-333722-ndth5zne	152	2	,	,	,
cord-333722-ndth5zne	152	3	in	in	IN
cord-333722-ndth5zne	152	4	murine	murine	JJ
cord-333722-ndth5zne	152	5	models	model	NNS
cord-333722-ndth5zne	152	6	infected	infect	VBN
cord-333722-ndth5zne	152	7	with	with	IN
cord-333722-ndth5zne	152	8	the	the	DT
cord-333722-ndth5zne	152	9	2009	2009	CD
cord-333722-ndth5zne	152	10	H1N1	H1N1	NNP
cord-333722-ndth5zne	152	11	pandemic	pandemic	NN
cord-333722-ndth5zne	152	12	influenza	influenza	NN
cord-333722-ndth5zne	152	13	,	,	,
cord-333722-ndth5zne	152	14	S1P1	S1P1	NNP
cord-333722-ndth5zne	152	15	receptor	receptor	NN
cord-333722-ndth5zne	152	16	agonists	agonist	NNS
cord-333722-ndth5zne	152	17	alone	alone	RB
cord-333722-ndth5zne	152	18	reduced	reduce	VBN
cord-333722-ndth5zne	152	19	over	over	IN
cord-333722-ndth5zne	152	20	80	80	CD
cord-333722-ndth5zne	152	21	%	%	NN
cord-333722-ndth5zne	152	22	of	of	IN
cord-333722-ndth5zne	152	23	deaths	death	NNS
cord-333722-ndth5zne	152	24	from	from	IN
cord-333722-ndth5zne	152	25	lethal	lethal	JJ
cord-333722-ndth5zne	152	26	infection	infection	NN
cord-333722-ndth5zne	152	27	compared	compare	VBN
cord-333722-ndth5zne	152	28	to	to	IN
cord-333722-ndth5zne	152	29	50	50	CD
cord-333722-ndth5zne	152	30	%	%	NN
cord-333722-ndth5zne	152	31	protection	protection	NN
cord-333722-ndth5zne	152	32	offered	offer	VBN
cord-333722-ndth5zne	152	33	by	by	IN
cord-333722-ndth5zne	152	34	the	the	DT
cord-333722-ndth5zne	152	35	antiviral	antiviral	JJ
cord-333722-ndth5zne	152	36	neuraminidase	neuraminidase	NN
cord-333722-ndth5zne	152	37	inhibitor	inhibitor	NN
cord-333722-ndth5zne	152	38	,	,	,
cord-333722-ndth5zne	152	39	oseltamivir	oseltamivir	FW
cord-333722-ndth5zne	152	40	.	.	.
cord-333722-ndth5zne	153	1	36	36	CD
cord-333722-ndth5zne	154	1	Furthermore	furthermore	RB
cord-333722-ndth5zne	154	2	,	,	,
cord-333722-ndth5zne	154	3	a	a	DT
cord-333722-ndth5zne	154	4	combined	combine	VBN
cord-333722-ndth5zne	154	5	therapy	therapy	NN
cord-333722-ndth5zne	154	6	with	with	IN
cord-333722-ndth5zne	154	7	the	the	DT
cord-333722-ndth5zne	154	8	two	two	CD
cord-333722-ndth5zne	154	9	agents	agent	NNS
cord-333722-ndth5zne	154	10	can	can	MD
cord-333722-ndth5zne	154	11	achieve	achieve	VB
cord-333722-ndth5zne	154	12	an	an	DT
cord-333722-ndth5zne	154	13	optimal	optimal	JJ
cord-333722-ndth5zne	154	14	protection	protection	NN
cord-333722-ndth5zne	154	15	of	of	IN
cord-333722-ndth5zne	154	16	96	96	CD
cord-333722-ndth5zne	154	17	%	%	NN
cord-333722-ndth5zne	154	18	.	.	.
cord-333722-ndth5zne	155	1	36	36	CD
cord-333722-ndth5zne	156	1	This	this	DT
cord-333722-ndth5zne	156	2	is	be	VBZ
cord-333722-ndth5zne	156	3	by	by	IN
cord-333722-ndth5zne	156	4	far	far	RB
cord-333722-ndth5zne	156	5	the	the	DT
cord-333722-ndth5zne	156	6	most	most	RBS
cord-333722-ndth5zne	156	7	promising	promising	JJ
cord-333722-ndth5zne	156	8	result	result	NN
cord-333722-ndth5zne	156	9	in	in	IN
cord-333722-ndth5zne	156	10	improving	improve	VBG
cord-333722-ndth5zne	156	11	the	the	DT
cord-333722-ndth5zne	156	12	outcome	outcome	NN
cord-333722-ndth5zne	156	13	of	of	IN
cord-333722-ndth5zne	156	14	severe	severe	JJ
cord-333722-ndth5zne	156	15	influenza	influenza	NN
cord-333722-ndth5zne	156	16	using	use	VBG
cord-333722-ndth5zne	156	17	an	an	DT
cord-333722-ndth5zne	156	18	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	156	19	strategy	strategy	NN
cord-333722-ndth5zne	156	20	.	.	.
cord-333722-ndth5zne	157	1	Selective	Selective	NNP
cord-333722-ndth5zne	157	2	COX	COX	NNP
cord-333722-ndth5zne	157	3	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	157	4	,	,	,
cord-333722-ndth5zne	157	5	such	such	JJ
cord-333722-ndth5zne	157	6	as	as	IN
cord-333722-ndth5zne	157	7	celecoxib	celecoxib	NNP
cord-333722-ndth5zne	157	8	and	and	CC
cord-333722-ndth5zne	157	9	mesalazine	mesalazine	NN
cord-333722-ndth5zne	157	10	,	,	,
cord-333722-ndth5zne	157	11	have	have	VBP
cord-333722-ndth5zne	157	12	been	be	VBN
cord-333722-ndth5zne	157	13	widely	widely	RB
cord-333722-ndth5zne	157	14	used	use	VBN
cord-333722-ndth5zne	157	15	in	in	IN
cord-333722-ndth5zne	157	16	clinics	clinic	NNS
cord-333722-ndth5zne	157	17	for	for	IN
cord-333722-ndth5zne	157	18	their	-PRON-	PRP$
cord-333722-ndth5zne	157	19	antipyretic	antipyretic	JJ
cord-333722-ndth5zne	157	20	,	,	,
cord-333722-ndth5zne	157	21	analgesic	analgesic	JJ
cord-333722-ndth5zne	157	22	,	,	,
cord-333722-ndth5zne	157	23	and	and	CC
cord-333722-ndth5zne	157	24	anti	anti	JJ
cord-333722-ndth5zne	157	25	-	-	JJ
cord-333722-ndth5zne	157	26	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	157	27	properties	property	NNS
cord-333722-ndth5zne	157	28	.	.	.
cord-333722-ndth5zne	158	1	The	the	DT
cord-333722-ndth5zne	158	2	monotherapy	monotherapy	NN
cord-333722-ndth5zne	158	3	of	of	IN
cord-333722-ndth5zne	158	4	celecoxib	celecoxib	NNS
cord-333722-ndth5zne	158	5	in	in	IN
cord-333722-ndth5zne	158	6	a	a	DT
cord-333722-ndth5zne	158	7	murine	murine	JJ
cord-333722-ndth5zne	158	8	model	model	NN
cord-333722-ndth5zne	158	9	of	of	IN
cord-333722-ndth5zne	158	10	influenza	influenza	NN
cord-333722-ndth5zne	158	11	does	do	VBZ
cord-333722-ndth5zne	158	12	not	not	RB
cord-333722-ndth5zne	158	13	considerably	considerably	RB
cord-333722-ndth5zne	158	14	modulate	modulate	VB
cord-333722-ndth5zne	158	15	disease	disease	NN
cord-333722-ndth5zne	158	16	severity	severity	NN
cord-333722-ndth5zne	158	17	.	.	.
cord-333722-ndth5zne	159	1	37	37	CD
cord-333722-ndth5zne	160	1	However	however	RB
cord-333722-ndth5zne	160	2	,	,	,
cord-333722-ndth5zne	160	3	the	the	DT
cord-333722-ndth5zne	160	4	use	use	NN
cord-333722-ndth5zne	160	5	of	of	IN
cord-333722-ndth5zne	160	6	COX-2	COX-2	NNP
cord-333722-ndth5zne	160	7	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	160	8	in	in	IN
cord-333722-ndth5zne	160	9	combination	combination	NN
cord-333722-ndth5zne	160	10	with	with	IN
cord-333722-ndth5zne	160	11	neuraminidase	neuraminidase	FW
cord-333722-ndth5zne	160	12	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	160	13	has	have	VBZ
cord-333722-ndth5zne	160	14	been	be	VBN
cord-333722-ndth5zne	160	15	shown	show	VBN
cord-333722-ndth5zne	160	16	to	to	TO
cord-333722-ndth5zne	160	17	improve	improve	VB
cord-333722-ndth5zne	160	18	the	the	DT
cord-333722-ndth5zne	160	19	survival	survival	NN
cord-333722-ndth5zne	160	20	of	of	IN
cord-333722-ndth5zne	160	21	mice	mouse	NNS
cord-333722-ndth5zne	160	22	infected	infect	VBN
cord-333722-ndth5zne	160	23	with	with	IN
cord-333722-ndth5zne	160	24	H5N1	H5N1	NNP
cord-333722-ndth5zne	160	25	influenza	influenza	NN
cord-333722-ndth5zne	160	26	.	.	.
cord-333722-ndth5zne	161	1	32	32	CD
cord-333722-ndth5zne	162	1	A	a	DT
cord-333722-ndth5zne	162	2	triple	triple	JJ
cord-333722-ndth5zne	162	3	combination	combination	NN
cord-333722-ndth5zne	162	4	therapy	therapy	NN
cord-333722-ndth5zne	162	5	of	of	IN
cord-333722-ndth5zne	162	6	zalamivir	zalamivir	NNP
cord-333722-ndth5zne	162	7	,	,	,
cord-333722-ndth5zne	162	8	celecoxib	celecoxib	NNP
cord-333722-ndth5zne	162	9	,	,	,
cord-333722-ndth5zne	162	10	and	and	CC
cord-333722-ndth5zne	162	11	mesalazine	mesalazine	NN
cord-333722-ndth5zne	162	12	significantly	significantly	RB
cord-333722-ndth5zne	162	13	reduced	reduce	VBD
cord-333722-ndth5zne	162	14	the	the	DT
cord-333722-ndth5zne	162	15	mortality	mortality	NN
cord-333722-ndth5zne	162	16	and	and	CC
cord-333722-ndth5zne	162	17	levels	level	NNS
cord-333722-ndth5zne	162	18	of	of	IN
cord-333722-ndth5zne	162	19	cytokines	cytokine	NNS
cord-333722-ndth5zne	162	20	/	/	SYM
cord-333722-ndth5zne	162	21	chemokines	chemokine	NNS
cord-333722-ndth5zne	162	22	of	of	IN
cord-333722-ndth5zne	162	23	infected	infected	JJ
cord-333722-ndth5zne	162	24	mice	mouse	NNS
cord-333722-ndth5zne	162	25	.	.	.
cord-333722-ndth5zne	163	1	32	32	CD
cord-333722-ndth5zne	164	1	These	these	DT
cord-333722-ndth5zne	164	2	data	datum	NNS
cord-333722-ndth5zne	164	3	demonstrate	demonstrate	VBP
cord-333722-ndth5zne	164	4	that	that	IN
cord-333722-ndth5zne	164	5	COX-2	cox-2	JJ
cord-333722-ndth5zne	164	6	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	164	7	may	may	MD
cord-333722-ndth5zne	164	8	provide	provide	VB
cord-333722-ndth5zne	164	9	additional	additional	JJ
cord-333722-ndth5zne	164	10	benefits	benefit	NNS
cord-333722-ndth5zne	164	11	when	when	WRB
cord-333722-ndth5zne	164	12	combined	combine	VBN
cord-333722-ndth5zne	164	13	with	with	IN
cord-333722-ndth5zne	164	14	antivirals	antiviral	NNS
cord-333722-ndth5zne	164	15	.	.	.
cord-333722-ndth5zne	165	1	As	as	IN
cord-333722-ndth5zne	165	2	reactive	reactive	JJ
cord-333722-ndth5zne	165	3	oxygen	oxygen	NN
cord-333722-ndth5zne	165	4	species	specie	NNS
cord-333722-ndth5zne	165	5	(	(	-LRB-
cord-333722-ndth5zne	165	6	ROS	ROS	NNP
cord-333722-ndth5zne	165	7	)	)	-RRB-
cord-333722-ndth5zne	165	8	play	play	VB
cord-333722-ndth5zne	165	9	a	a	DT
cord-333722-ndth5zne	165	10	central	central	JJ
cord-333722-ndth5zne	165	11	role	role	NN
cord-333722-ndth5zne	165	12	in	in	IN
cord-333722-ndth5zne	165	13	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	165	14	responses	response	NNS
cord-333722-ndth5zne	165	15	and	and	CC
cord-333722-ndth5zne	165	16	viral	viral	JJ
cord-333722-ndth5zne	165	17	replication	replication	NN
cord-333722-ndth5zne	165	18	,	,	,
cord-333722-ndth5zne	165	19	antioxidants	antioxidant	NNS
cord-333722-ndth5zne	165	20	that	that	WDT
cord-333722-ndth5zne	165	21	exert	exert	VBP
cord-333722-ndth5zne	165	22	antiviral	antiviral	JJ
cord-333722-ndth5zne	165	23	and	and	CC
cord-333722-ndth5zne	165	24	anti	anti	JJ
cord-333722-ndth5zne	165	25	-	-	JJ
cord-333722-ndth5zne	165	26	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	165	27	effects	effect	NNS
cord-333722-ndth5zne	165	28	may	may	MD
cord-333722-ndth5zne	165	29	also	also	RB
cord-333722-ndth5zne	165	30	be	be	VB
cord-333722-ndth5zne	165	31	effective	effective	JJ
cord-333722-ndth5zne	165	32	for	for	IN
cord-333722-ndth5zne	165	33	the	the	DT
cord-333722-ndth5zne	165	34	treatment	treatment	NN
cord-333722-ndth5zne	165	35	of	of	IN
cord-333722-ndth5zne	165	36	cytokine	cytokine	NN
cord-333722-ndth5zne	165	37	storm	storm	NN
cord-333722-ndth5zne	165	38	induced	induce	VBN
cord-333722-ndth5zne	165	39	by	by	IN
cord-333722-ndth5zne	165	40	severe	severe	JJ
cord-333722-ndth5zne	165	41	influenza	influenza	NN
cord-333722-ndth5zne	165	42	.	.	.
cord-333722-ndth5zne	166	1	38	38	CD
cord-333722-ndth5zne	166	2	N	n	NN
cord-333722-ndth5zne	166	3	-	-	HYPH
cord-333722-ndth5zne	166	4	acetylcysteine	acetylcysteine	NN
cord-333722-ndth5zne	166	5	(	(	-LRB-
cord-333722-ndth5zne	166	6	NAC	NAC	NNP
cord-333722-ndth5zne	166	7	)	)	-RRB-
cord-333722-ndth5zne	166	8	,	,	,
cord-333722-ndth5zne	166	9	a	a	DT
cord-333722-ndth5zne	166	10	modified	modify	VBN
cord-333722-ndth5zne	166	11	form	form	NN
cord-333722-ndth5zne	166	12	of	of	IN
cord-333722-ndth5zne	166	13	the	the	DT
cord-333722-ndth5zne	166	14	amino	amino	NN
cord-333722-ndth5zne	166	15	acid	acid	NN
cord-333722-ndth5zne	166	16	cysteine	cysteine	NN
cord-333722-ndth5zne	166	17	,	,	,
cord-333722-ndth5zne	166	18	was	be	VBD
cord-333722-ndth5zne	166	19	shown	show	VBN
cord-333722-ndth5zne	166	20	to	to	TO
cord-333722-ndth5zne	166	21	inhibit	inhibit	VB
cord-333722-ndth5zne	166	22	both	both	DT
cord-333722-ndth5zne	166	23	H5N1	H5N1	NNP
cord-333722-ndth5zne	166	24	replication	replication	NN
cord-333722-ndth5zne	166	25	and	and	CC
cord-333722-ndth5zne	166	26	H5N1-induced	h5n1-induced	JJ
cord-333722-ndth5zne	166	27	production	production	NN
cord-333722-ndth5zne	166	28	of	of	IN
cord-333722-ndth5zne	166	29	pro	pro	JJ
cord-333722-ndth5zne	166	30	-	-	JJ
cord-333722-ndth5zne	166	31	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	166	32	molecules	molecule	NNS
cord-333722-ndth5zne	166	33	(	(	-LRB-
cord-333722-ndth5zne	166	34	e.g.	e.g.	RB
cord-333722-ndth5zne	166	35	,	,	,
cord-333722-ndth5zne	166	36	IL6	il6	NN
cord-333722-ndth5zne	166	37	,	,	,
cord-333722-ndth5zne	166	38	CCL5	CCL5	NNP
cord-333722-ndth5zne	166	39	,	,	,
cord-333722-ndth5zne	166	40	CXCL8	CXCL8	NNP
cord-333722-ndth5zne	166	41	,	,	,
cord-333722-ndth5zne	166	42	and	and	CC
cord-333722-ndth5zne	166	43	CXCL10	cxcl10	LS
cord-333722-ndth5zne	166	44	)	)	-RRB-
cord-333722-ndth5zne	166	45	in	in	IN
cord-333722-ndth5zne	166	46	lung	lung	NN
cord-333722-ndth5zne	166	47	epithelial	epithelial	JJ
cord-333722-ndth5zne	166	48	cells	cell	NNS
cord-333722-ndth5zne	166	49	.	.	.
cord-333722-ndth5zne	167	1	39	39	CD
cord-333722-ndth5zne	167	2	Glycyrrhizin	Glycyrrhizin	NNP
cord-333722-ndth5zne	167	3	,	,	,
cord-333722-ndth5zne	167	4	an	an	DT
cord-333722-ndth5zne	167	5	inhibitor	inhibitor	NN
cord-333722-ndth5zne	167	6	of	of	IN
cord-333722-ndth5zne	167	7	hydroxysteroid	hydroxysteroid	NN
cord-333722-ndth5zne	167	8	dehydrogenase	dehydrogenase	NN
cord-333722-ndth5zne	167	9	,	,	,
cord-333722-ndth5zne	167	10	was	be	VBD
cord-333722-ndth5zne	167	11	shown	show	VBN
cord-333722-ndth5zne	167	12	to	to	TO
cord-333722-ndth5zne	167	13	inhibit	inhibit	VB
cord-333722-ndth5zne	167	14	H5N1	H5N1	NNP
cord-333722-ndth5zne	167	15	replication	replication	NN
cord-333722-ndth5zne	167	16	and	and	CC
cord-333722-ndth5zne	167	17	pro	pro	JJ
cord-333722-ndth5zne	167	18	-	-	JJ
cord-333722-ndth5zne	167	19	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	167	20	gene	gene	NN
cord-333722-ndth5zne	167	21	expression	expression	NN
cord-333722-ndth5zne	167	22	.	.	.
cord-333722-ndth5zne	168	1	40	40	CD
cord-333722-ndth5zne	169	1	Interestingly	interestingly	RB
cord-333722-ndth5zne	169	2	,	,	,
cord-333722-ndth5zne	169	3	an	an	DT
cord-333722-ndth5zne	169	4	investigation	investigation	NN
cord-333722-ndth5zne	169	5	showed	show	VBD
cord-333722-ndth5zne	169	6	that	that	IN
cord-333722-ndth5zne	169	7	vitamin	vitamin	NN
cord-333722-ndth5zne	169	8	C	c	NN
cord-333722-ndth5zne	169	9	was	be	VBD
cord-333722-ndth5zne	169	10	beneficial	beneficial	JJ
cord-333722-ndth5zne	169	11	for	for	IN
cord-333722-ndth5zne	169	12	patients	patient	NNS
cord-333722-ndth5zne	169	13	suffering	suffer	VBG
cord-333722-ndth5zne	169	14	from	from	IN
cord-333722-ndth5zne	169	15	severe	severe	JJ
cord-333722-ndth5zne	169	16	avian	avian	JJ
cord-333722-ndth5zne	169	17	influenza	influenza	NN
cord-333722-ndth5zne	169	18	.	.	.
cord-333722-ndth5zne	170	1	41	41	CD
cord-333722-ndth5zne	171	1	In	in	IN
cord-333722-ndth5zne	171	2	fact	fact	NN
cord-333722-ndth5zne	171	3	,	,	,
cord-333722-ndth5zne	171	4	many	many	JJ
cord-333722-ndth5zne	171	5	plant	plant	NN
cord-333722-ndth5zne	171	6	-	-	HYPH
cord-333722-ndth5zne	171	7	derived	derive	VBN
cord-333722-ndth5zne	171	8	antioxidants	antioxidant	NNS
cord-333722-ndth5zne	171	9	(	(	-LRB-
cord-333722-ndth5zne	171	10	e.g.	e.g.	RB
cord-333722-ndth5zne	171	11	,	,	,
cord-333722-ndth5zne	171	12	polyphenol	polyphenol	NN
cord-333722-ndth5zne	171	13	,	,	,
cord-333722-ndth5zne	171	14	flavonoids	flavonoid	NNS
cord-333722-ndth5zne	171	15	,	,	,
cord-333722-ndth5zne	171	16	etc	etc	FW
cord-333722-ndth5zne	171	17	.	.	.
cord-333722-ndth5zne	171	18	)	)	-RRB-
cord-333722-ndth5zne	171	19	could	could	MD
cord-333722-ndth5zne	171	20	also	also	RB
cord-333722-ndth5zne	171	21	reduce	reduce	VB
cord-333722-ndth5zne	171	22	the	the	DT
cord-333722-ndth5zne	171	23	damage	damage	NN
cord-333722-ndth5zne	171	24	of	of	IN
cord-333722-ndth5zne	171	25	epithelial	epithelial	JJ
cord-333722-ndth5zne	171	26	cells	cell	NNS
cord-333722-ndth5zne	171	27	and	and	CC
cord-333722-ndth5zne	171	28	the	the	DT
cord-333722-ndth5zne	171	29	mortality	mortality	NN
cord-333722-ndth5zne	171	30	of	of	IN
cord-333722-ndth5zne	171	31	mice	mouse	NNS
cord-333722-ndth5zne	171	32	caused	cause	VBN
cord-333722-ndth5zne	171	33	by	by	IN
cord-333722-ndth5zne	171	34	lethal	lethal	JJ
cord-333722-ndth5zne	171	35	influenza	influenza	NN
cord-333722-ndth5zne	171	36	.	.	.
cord-333722-ndth5zne	172	1	[	[	-LRB-
cord-333722-ndth5zne	172	2	42	42	CD
cord-333722-ndth5zne	172	3	]	]	-RRB-
cord-333722-ndth5zne	172	4	[	[	-LRB-
cord-333722-ndth5zne	172	5	43	43	CD
cord-333722-ndth5zne	172	6	]	]	-RRB-
cord-333722-ndth5zne	172	7	[	[	-LRB-
cord-333722-ndth5zne	172	8	44	44	CD
cord-333722-ndth5zne	172	9	]	]	-RRB-
cord-333722-ndth5zne	173	1	However	however	RB
cord-333722-ndth5zne	173	2	,	,	,
cord-333722-ndth5zne	173	3	current	current	JJ
cord-333722-ndth5zne	173	4	evidence	evidence	NN
cord-333722-ndth5zne	173	5	indicates	indicate	VBZ
cord-333722-ndth5zne	173	6	that	that	IN
cord-333722-ndth5zne	173	7	monotherapy	monotherapy	IN
cord-333722-ndth5zne	173	8	using	use	VBG
cord-333722-ndth5zne	173	9	antioxidants	antioxidant	NNS
cord-333722-ndth5zne	173	10	had	have	VBD
cord-333722-ndth5zne	173	11	a	a	DT
cord-333722-ndth5zne	173	12	limited	limited	JJ
cord-333722-ndth5zne	173	13	effect	effect	NN
cord-333722-ndth5zne	173	14	on	on	IN
cord-333722-ndth5zne	173	15	cytokine	cytokine	NN
cord-333722-ndth5zne	173	16	storm	storm	NN
cord-333722-ndth5zne	173	17	,	,	,
cord-333722-ndth5zne	173	18	and	and	CC
cord-333722-ndth5zne	173	19	a	a	DT
cord-333722-ndth5zne	173	20	combination	combination	NN
cord-333722-ndth5zne	173	21	with	with	IN
cord-333722-ndth5zne	173	22	antivirals	antiviral	NNS
cord-333722-ndth5zne	173	23	would	would	MD
cord-333722-ndth5zne	173	24	still	still	RB
cord-333722-ndth5zne	173	25	be	be	VB
cord-333722-ndth5zne	173	26	needed	need	VBN
cord-333722-ndth5zne	173	27	.	.	.
cord-333722-ndth5zne	174	1	45	45	CD
cord-333722-ndth5zne	174	2	3.6	3.6	CD
cord-333722-ndth5zne	174	3	.	.	.
cord-333722-ndth5zne	175	1	Anti	anti	JJ
cord-333722-ndth5zne	175	2	-	-	JJ
cord-333722-ndth5zne	175	3	TNF	TNF	NNP
cord-333722-ndth5zne	175	4	therapy	therapy	NN
cord-333722-ndth5zne	176	1	Although	although	IN
cord-333722-ndth5zne	176	2	we	-PRON-	PRP
cord-333722-ndth5zne	176	3	still	still	RB
cord-333722-ndth5zne	176	4	do	do	VBP
cord-333722-ndth5zne	176	5	not	not	RB
cord-333722-ndth5zne	176	6	fully	fully	RB
cord-333722-ndth5zne	176	7	understand	understand	VB
cord-333722-ndth5zne	176	8	the	the	DT
cord-333722-ndth5zne	176	9	complex	complex	JJ
cord-333722-ndth5zne	176	10	nature	nature	NN
cord-333722-ndth5zne	176	11	of	of	IN
cord-333722-ndth5zne	176	12	cytokine	cytokine	NN
cord-333722-ndth5zne	176	13	storm	storm	NN
cord-333722-ndth5zne	176	14	,	,	,
cord-333722-ndth5zne	176	15	TNF	TNF	NNP
cord-333722-ndth5zne	176	16	is	be	VBZ
cord-333722-ndth5zne	176	17	considered	consider	VBN
cord-333722-ndth5zne	176	18	to	to	TO
cord-333722-ndth5zne	176	19	be	be	VB
cord-333722-ndth5zne	176	20	a	a	DT
cord-333722-ndth5zne	176	21	key	key	JJ
cord-333722-ndth5zne	176	22	cytokine	cytokine	NN
cord-333722-ndth5zne	176	23	for	for	IN
cord-333722-ndth5zne	176	24	acute	acute	JJ
cord-333722-ndth5zne	176	25	viral	viral	JJ
cord-333722-ndth5zne	176	26	diseases	disease	NNS
cord-333722-ndth5zne	176	27	(	(	-LRB-
cord-333722-ndth5zne	176	28	e.g.	e.g.	RB
cord-333722-ndth5zne	176	29	,	,	,
cord-333722-ndth5zne	176	30	influenza	influenza	NN
cord-333722-ndth5zne	176	31	virus	virus	NN
cord-333722-ndth5zne	176	32	,	,	,
cord-333722-ndth5zne	176	33	dengue	dengue	NN
cord-333722-ndth5zne	176	34	virus	virus	NN
cord-333722-ndth5zne	176	35	,	,	,
cord-333722-ndth5zne	176	36	and	and	CC
cord-333722-ndth5zne	176	37	Ebola	Ebola	NNP
cord-333722-ndth5zne	176	38	virus	virus	NN
cord-333722-ndth5zne	176	39	)	)	-RRB-
cord-333722-ndth5zne	176	40	.	.	.
cord-333722-ndth5zne	177	1	7	7	CD
cord-333722-ndth5zne	178	1	Indeed	indeed	RB
cord-333722-ndth5zne	178	2	,	,	,
cord-333722-ndth5zne	178	3	experimental	experimental	JJ
cord-333722-ndth5zne	178	4	studies	study	NNS
cord-333722-ndth5zne	178	5	have	have	VBP
cord-333722-ndth5zne	178	6	shown	show	VBN
cord-333722-ndth5zne	178	7	that	that	IN
cord-333722-ndth5zne	178	8	TNF	TNF	NNP
cord-333722-ndth5zne	178	9	not	not	RB
cord-333722-ndth5zne	178	10	only	only	RB
cord-333722-ndth5zne	178	11	affects	affect	VBZ
cord-333722-ndth5zne	178	12	the	the	DT
cord-333722-ndth5zne	178	13	balance	balance	NN
cord-333722-ndth5zne	178	14	of	of	IN
cord-333722-ndth5zne	178	15	the	the	DT
cord-333722-ndth5zne	178	16	local	local	JJ
cord-333722-ndth5zne	178	17	microenvironment	microenvironment	NN
cord-333722-ndth5zne	178	18	,	,	,
cord-333722-ndth5zne	178	19	but	but	CC
cord-333722-ndth5zne	178	20	it	-PRON-	PRP
cord-333722-ndth5zne	178	21	also	also	RB
cord-333722-ndth5zne	178	22	exerts	exert	VBZ
cord-333722-ndth5zne	178	23	broad	broad	JJ
cord-333722-ndth5zne	178	24	systemic	systemic	JJ
cord-333722-ndth5zne	178	25	effects	effect	NNS
cord-333722-ndth5zne	178	26	after	after	IN
cord-333722-ndth5zne	178	27	entering	enter	VBG
cord-333722-ndth5zne	178	28	into	into	IN
cord-333722-ndth5zne	178	29	the	the	DT
cord-333722-ndth5zne	178	30	circulation	circulation	NN
cord-333722-ndth5zne	178	31	.	.	.
cord-333722-ndth5zne	179	1	46	46	CD
cord-333722-ndth5zne	180	1	Thus	thus	RB
cord-333722-ndth5zne	180	2	,	,	,
cord-333722-ndth5zne	180	3	anti	anti	JJ
cord-333722-ndth5zne	180	4	-	-	JJ
cord-333722-ndth5zne	180	5	TNF	tnf	JJ
cord-333722-ndth5zne	180	6	strategies	strategy	NNS
cord-333722-ndth5zne	180	7	may	may	MD
cord-333722-ndth5zne	180	8	be	be	VB
cord-333722-ndth5zne	180	9	a	a	DT
cord-333722-ndth5zne	180	10	reasonable	reasonable	JJ
cord-333722-ndth5zne	180	11	way	way	NN
cord-333722-ndth5zne	180	12	to	to	TO
cord-333722-ndth5zne	180	13	treat	treat	VB
cord-333722-ndth5zne	180	14	severe	severe	JJ
cord-333722-ndth5zne	180	15	influenza	influenza	NN
cord-333722-ndth5zne	180	16	.	.	.
cord-333722-ndth5zne	181	1	Studies	study	NNS
cord-333722-ndth5zne	181	2	have	have	VBP
cord-333722-ndth5zne	181	3	reported	report	VBN
cord-333722-ndth5zne	181	4	that	that	IN
cord-333722-ndth5zne	181	5	treatments	treatment	NNS
cord-333722-ndth5zne	181	6	using	use	VBG
cord-333722-ndth5zne	181	7	TNF	tnf	NN
cord-333722-ndth5zne	181	8	-	-	HYPH
cord-333722-ndth5zne	181	9	neutralizing	neutralize	VBG
cord-333722-ndth5zne	181	10	monoclonal	monoclonal	JJ
cord-333722-ndth5zne	181	11	antibodies	antibody	NNS
cord-333722-ndth5zne	181	12	or	or	CC
cord-333722-ndth5zne	181	13	soluble	soluble	JJ
cord-333722-ndth5zne	181	14	TNF	TNF	NNP
cord-333722-ndth5zne	181	15	receptor	receptor	NN
cord-333722-ndth5zne	181	16	fusion	fusion	NN
cord-333722-ndth5zne	181	17	proteins	protein	NNS
cord-333722-ndth5zne	181	18	can	can	MD
cord-333722-ndth5zne	181	19	reduce	reduce	VB
cord-333722-ndth5zne	181	20	the	the	DT
cord-333722-ndth5zne	181	21	cytokine	cytokine	NN
cord-333722-ndth5zne	181	22	production	production	NN
cord-333722-ndth5zne	181	23	and	and	CC
cord-333722-ndth5zne	181	24	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	181	25	cell	cell	NN
cord-333722-ndth5zne	181	26	infiltrates	infiltrate	VBZ
cord-333722-ndth5zne	181	27	in	in	IN
cord-333722-ndth5zne	181	28	influenzainfected	influenzainfected	JJ
cord-333722-ndth5zne	181	29	murine	murine	JJ
cord-333722-ndth5zne	181	30	lungs	lung	NNS
cord-333722-ndth5zne	181	31	.	.	.
cord-333722-ndth5zne	182	1	47	47	CD
cord-333722-ndth5zne	182	2	,	,	,
cord-333722-ndth5zne	182	3	48	48	CD
cord-333722-ndth5zne	183	1	However	however	RB
cord-333722-ndth5zne	183	2	,	,	,
cord-333722-ndth5zne	183	3	no	no	DT
cord-333722-ndth5zne	183	4	improved	improve	VBN
cord-333722-ndth5zne	183	5	survival	survival	NN
cord-333722-ndth5zne	183	6	rates	rate	NNS
cord-333722-ndth5zne	183	7	were	be	VBD
cord-333722-ndth5zne	183	8	observed	observe	VBN
cord-333722-ndth5zne	183	9	in	in	IN
cord-333722-ndth5zne	183	10	these	these	DT
cord-333722-ndth5zne	183	11	studies	study	NNS
cord-333722-ndth5zne	183	12	.	.	.
cord-333722-ndth5zne	184	1	47	47	CD
cord-333722-ndth5zne	184	2	,	,	,
cord-333722-ndth5zne	184	3	48	48	CD
cord-333722-ndth5zne	185	1	Thus	thus	RB
cord-333722-ndth5zne	185	2	,	,	,
cord-333722-ndth5zne	185	3	the	the	DT
cord-333722-ndth5zne	185	4	evidence	evidence	NN
cord-333722-ndth5zne	185	5	for	for	IN
cord-333722-ndth5zne	185	6	the	the	DT
cord-333722-ndth5zne	185	7	clinical	clinical	JJ
cord-333722-ndth5zne	185	8	use	use	NN
cord-333722-ndth5zne	185	9	of	of	IN
cord-333722-ndth5zne	185	10	anti	anti	JJ
cord-333722-ndth5zne	185	11	-	-	JJ
cord-333722-ndth5zne	185	12	TNF	tnf	JJ
cord-333722-ndth5zne	185	13	therapy	therapy	NN
cord-333722-ndth5zne	185	14	in	in	IN
cord-333722-ndth5zne	185	15	severe	severe	JJ
cord-333722-ndth5zne	185	16	influenza	influenza	NN
cord-333722-ndth5zne	185	17	is	be	VBZ
cord-333722-ndth5zne	185	18	currently	currently	RB
cord-333722-ndth5zne	185	19	inconsistent	inconsistent	JJ
cord-333722-ndth5zne	185	20	.	.	.
cord-333722-ndth5zne	186	1	Further	further	JJ
cord-333722-ndth5zne	186	2	clinical	clinical	JJ
cord-333722-ndth5zne	186	3	trials	trial	NNS
cord-333722-ndth5zne	186	4	to	to	TO
cord-333722-ndth5zne	186	5	evaluate	evaluate	VB
cord-333722-ndth5zne	186	6	the	the	DT
cord-333722-ndth5zne	186	7	efficacy	efficacy	NN
cord-333722-ndth5zne	186	8	of	of	IN
cord-333722-ndth5zne	186	9	anti	anti	JJ
cord-333722-ndth5zne	186	10	-	-	JJ
cord-333722-ndth5zne	186	11	TNF	tnf	JJ
cord-333722-ndth5zne	186	12	strategies	strategy	NNS
cord-333722-ndth5zne	186	13	are	be	VBP
cord-333722-ndth5zne	186	14	still	still	RB
cord-333722-ndth5zne	186	15	needed	need	VBN
cord-333722-ndth5zne	186	16	.	.	.
cord-333722-ndth5zne	187	1	Intravenous	intravenous	JJ
cord-333722-ndth5zne	187	2	immunoglobulin	immunoglobulin	NN
cord-333722-ndth5zne	187	3	(	(	-LRB-
cord-333722-ndth5zne	187	4	IVIG	IVIG	NNP
cord-333722-ndth5zne	187	5	)	)	-RRB-
cord-333722-ndth5zne	188	1	therapy	therapy	NN
cord-333722-ndth5zne	188	2	uses	use	VBZ
cord-333722-ndth5zne	188	3	concentrated	concentrated	JJ
cord-333722-ndth5zne	188	4	globulin	globulin	NN
cord-333722-ndth5zne	188	5	preparations	preparation	NNS
cord-333722-ndth5zne	188	6	from	from	IN
cord-333722-ndth5zne	188	7	pooled	pool	VBN
cord-333722-ndth5zne	188	8	human	human	JJ
cord-333722-ndth5zne	188	9	plasma	plasma	NN
cord-333722-ndth5zne	188	10	for	for	IN
cord-333722-ndth5zne	188	11	the	the	DT
cord-333722-ndth5zne	188	12	treatment	treatment	NN
cord-333722-ndth5zne	188	13	of	of	IN
cord-333722-ndth5zne	188	14	acute	acute	JJ
cord-333722-ndth5zne	188	15	infections	infection	NNS
cord-333722-ndth5zne	188	16	.	.	.
cord-333722-ndth5zne	189	1	The	the	DT
cord-333722-ndth5zne	189	2	mechanism	mechanism	NN
cord-333722-ndth5zne	189	3	by	by	IN
cord-333722-ndth5zne	189	4	which	which	WDT
cord-333722-ndth5zne	189	5	IVIG	IVIG	NNP
cord-333722-ndth5zne	189	6	suppresses	suppress	VBZ
cord-333722-ndth5zne	189	7	harmful	harmful	JJ
cord-333722-ndth5zne	189	8	inflammation	inflammation	NN
cord-333722-ndth5zne	189	9	has	have	VBZ
cord-333722-ndth5zne	189	10	not	not	RB
cord-333722-ndth5zne	189	11	been	be	VBN
cord-333722-ndth5zne	189	12	definitively	definitively	RB
cord-333722-ndth5zne	189	13	identified	identify	VBN
cord-333722-ndth5zne	189	14	.	.	.
cord-333722-ndth5zne	190	1	It	-PRON-	PRP
cord-333722-ndth5zne	190	2	is	be	VBZ
cord-333722-ndth5zne	190	3	believed	believe	VBN
cord-333722-ndth5zne	190	4	to	to	TO
cord-333722-ndth5zne	190	5	involve	involve	VB
cord-333722-ndth5zne	190	6	multiple	multiple	JJ
cord-333722-ndth5zne	190	7	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	190	8	effects	effect	NNS
cord-333722-ndth5zne	190	9	by	by	IN
cord-333722-ndth5zne	190	10	blocking	block	VBG
cord-333722-ndth5zne	190	11	Fc	Fc	NNP
cord-333722-ndth5zne	190	12	receptors	receptor	NNS
cord-333722-ndth5zne	190	13	,	,	,
cord-333722-ndth5zne	190	14	which	which	WDT
cord-333722-ndth5zne	190	15	are	be	VBP
cord-333722-ndth5zne	190	16	associated	associate	VBN
cord-333722-ndth5zne	190	17	with	with	IN
cord-333722-ndth5zne	190	18	tolerance	tolerance	NN
cord-333722-ndth5zne	190	19	to	to	IN
cord-333722-ndth5zne	190	20	self	self	NN
cord-333722-ndth5zne	190	21	and	and	CC
cord-333722-ndth5zne	190	22	severity	severity	NN
cord-333722-ndth5zne	190	23	of	of	IN
cord-333722-ndth5zne	190	24	the	the	DT
cord-333722-ndth5zne	190	25	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	190	26	state	state	NN
cord-333722-ndth5zne	190	27	.	.	.
cord-333722-ndth5zne	191	1	49	49	CD
cord-333722-ndth5zne	192	1	This	this	DT
cord-333722-ndth5zne	192	2	strategy	strategy	NN
cord-333722-ndth5zne	192	3	has	have	VBZ
cord-333722-ndth5zne	192	4	been	be	VBN
cord-333722-ndth5zne	192	5	used	use	VBN
cord-333722-ndth5zne	192	6	in	in	IN
cord-333722-ndth5zne	192	7	the	the	DT
cord-333722-ndth5zne	192	8	treatment	treatment	NN
cord-333722-ndth5zne	192	9	of	of	IN
cord-333722-ndth5zne	192	10	viral	viral	RB
cord-333722-ndth5zne	192	11	-	-	HYPH
cord-333722-ndth5zne	192	12	induced	induce	VBN
cord-333722-ndth5zne	192	13	cytokine	cytokine	NN
cord-333722-ndth5zne	192	14	storm	storm	NN
cord-333722-ndth5zne	192	15	and	and	CC
cord-333722-ndth5zne	192	16	was	be	VBD
cord-333722-ndth5zne	192	17	confirmed	confirm	VBN
cord-333722-ndth5zne	192	18	to	to	TO
cord-333722-ndth5zne	192	19	have	have	VB
cord-333722-ndth5zne	192	20	improved	improve	VBN
cord-333722-ndth5zne	192	21	the	the	DT
cord-333722-ndth5zne	192	22	outcome	outcome	NN
cord-333722-ndth5zne	192	23	in	in	IN
cord-333722-ndth5zne	192	24	infections	infection	NNS
cord-333722-ndth5zne	192	25	,	,	,
cord-333722-ndth5zne	192	26	such	such	JJ
cord-333722-ndth5zne	192	27	as	as	IN
cord-333722-ndth5zne	192	28	SARS	SARS	NNP
cord-333722-ndth5zne	192	29	and	and	CC
cord-333722-ndth5zne	192	30	the	the	DT
cord-333722-ndth5zne	192	31	2009	2009	CD
cord-333722-ndth5zne	192	32	H1N1	H1N1	NNP
cord-333722-ndth5zne	192	33	pandemic	pandemic	NN
cord-333722-ndth5zne	192	34	influenza	influenza	NN
cord-333722-ndth5zne	192	35	.	.	.
cord-333722-ndth5zne	193	1	50,51	50,51	CD
cord-333722-ndth5zne	193	2	A	a	DT
cord-333722-ndth5zne	193	3	meta	meta	JJ
cord-333722-ndth5zne	193	4	-	-	HYPH
cord-333722-ndth5zne	193	5	analysis	analysis	NN
cord-333722-ndth5zne	193	6	suggested	suggest	VBD
cord-333722-ndth5zne	193	7	that	that	IN
cord-333722-ndth5zne	193	8	early	early	JJ
cord-333722-ndth5zne	193	9	administration	administration	NN
cord-333722-ndth5zne	193	10	of	of	IN
cord-333722-ndth5zne	193	11	blood	blood	NN
cord-333722-ndth5zne	193	12	products	product	NNS
cord-333722-ndth5zne	193	13	could	could	MD
cord-333722-ndth5zne	193	14	have	have	VB
cord-333722-ndth5zne	193	15	reduced	reduce	VBN
cord-333722-ndth5zne	193	16	anywhere	anywhere	RB
cord-333722-ndth5zne	193	17	from	from	IN
cord-333722-ndth5zne	193	18	26	26	CD
cord-333722-ndth5zne	193	19	%	%	NN
cord-333722-ndth5zne	193	20	to	to	IN
cord-333722-ndth5zne	193	21	50	50	CD
cord-333722-ndth5zne	193	22	%	%	NN
cord-333722-ndth5zne	193	23	of	of	IN
cord-333722-ndth5zne	193	24	patients	patient	NNS
cord-333722-ndth5zne	193	25	'	'	POS
cord-333722-ndth5zne	193	26	deaths	death	NNS
cord-333722-ndth5zne	193	27	from	from	IN
cord-333722-ndth5zne	193	28	pneumonia	pneumonia	NN
cord-333722-ndth5zne	193	29	during	during	IN
cord-333722-ndth5zne	193	30	the	the	DT
cord-333722-ndth5zne	193	31	1918	1918	CD
cord-333722-ndth5zne	193	32	H1N1	H1N1	NNP
cord-333722-ndth5zne	193	33	influenza	influenza	NN
cord-333722-ndth5zne	193	34	pandemic	pandemic	NN
cord-333722-ndth5zne	193	35	.	.	.
cord-333722-ndth5zne	194	1	52	52	CD
cord-333722-ndth5zne	194	2	Evidence	evidence	NN
cord-333722-ndth5zne	194	3	of	of	IN
cord-333722-ndth5zne	194	4	a	a	DT
cord-333722-ndth5zne	194	5	beneficial	beneficial	JJ
cord-333722-ndth5zne	194	6	effect	effect	NN
cord-333722-ndth5zne	194	7	of	of	IN
cord-333722-ndth5zne	194	8	IVIG	IVIG	NNP
cord-333722-ndth5zne	194	9	therapy	therapy	NN
cord-333722-ndth5zne	194	10	has	have	VBZ
cord-333722-ndth5zne	194	11	been	be	VBN
cord-333722-ndth5zne	194	12	obtained	obtain	VBN
cord-333722-ndth5zne	194	13	in	in	IN
cord-333722-ndth5zne	194	14	the	the	DT
cord-333722-ndth5zne	194	15	2009	2009	CD
cord-333722-ndth5zne	194	16	H1N1	H1N1	NNP
cord-333722-ndth5zne	194	17	influenza	influenza	NN
cord-333722-ndth5zne	194	18	infections	infection	NNS
cord-333722-ndth5zne	194	19	.	.	.
cord-333722-ndth5zne	195	1	A	a	DT
cord-333722-ndth5zne	195	2	multivariate	multivariate	JJ
cord-333722-ndth5zne	195	3	analysis	analysis	NN
cord-333722-ndth5zne	195	4	of	of	IN
cord-333722-ndth5zne	195	5	the	the	DT
cord-333722-ndth5zne	195	6	22	22	CD
cord-333722-ndth5zne	195	7	patients	patient	NNS
cord-333722-ndth5zne	195	8	who	who	WP
cord-333722-ndth5zne	195	9	received	receive	VBD
cord-333722-ndth5zne	195	10	either	either	CC
cord-333722-ndth5zne	195	11	hyperimmune	hyperimmune	JJ
cord-333722-ndth5zne	195	12	or	or	CC
cord-333722-ndth5zne	195	13	normal	normal	JJ
cord-333722-ndth5zne	195	14	IVIG	ivig	NN
cord-333722-ndth5zne	195	15	within	within	IN
cord-333722-ndth5zne	195	16	five	five	CD
cord-333722-ndth5zne	195	17	days	day	NNS
cord-333722-ndth5zne	195	18	of	of	IN
cord-333722-ndth5zne	195	19	symptom	symptom	NN
cord-333722-ndth5zne	195	20	onset	onset	NN
cord-333722-ndth5zne	195	21	found	find	VBD
cord-333722-ndth5zne	195	22	that	that	IN
cord-333722-ndth5zne	195	23	hyperimmune	hyperimmune	NNP
cord-333722-ndth5zne	195	24	IVIG	IVIG	NNP
cord-333722-ndth5zne	195	25	treatment	treatment	NN
cord-333722-ndth5zne	195	26	was	be	VBD
cord-333722-ndth5zne	195	27	independently	independently	RB
cord-333722-ndth5zne	195	28	responsible	responsible	JJ
cord-333722-ndth5zne	195	29	for	for	IN
cord-333722-ndth5zne	195	30	the	the	DT
cord-333722-ndth5zne	195	31	reduced	reduce	VBN
cord-333722-ndth5zne	195	32	mortality	mortality	NN
cord-333722-ndth5zne	195	33	of	of	IN
cord-333722-ndth5zne	195	34	infection	infection	NN
cord-333722-ndth5zne	195	35	.	.	.
cord-333722-ndth5zne	196	1	50	50	CD
cord-333722-ndth5zne	197	1	These	these	DT
cord-333722-ndth5zne	197	2	results	result	NNS
cord-333722-ndth5zne	197	3	suggested	suggest	VBD
cord-333722-ndth5zne	197	4	that	that	IN
cord-333722-ndth5zne	197	5	passive	passive	JJ
cord-333722-ndth5zne	197	6	immunotherapy	immunotherapy	NN
cord-333722-ndth5zne	197	7	with	with	IN
cord-333722-ndth5zne	197	8	hyperimmune	hyperimmune	NNP
cord-333722-ndth5zne	197	9	globulin	globulin	NNP
cord-333722-ndth5zne	197	10	is	be	VBZ
cord-333722-ndth5zne	197	11	a	a	DT
cord-333722-ndth5zne	197	12	potential	potential	JJ
cord-333722-ndth5zne	197	13	strategy	strategy	NN
cord-333722-ndth5zne	197	14	for	for	IN
cord-333722-ndth5zne	197	15	the	the	DT
cord-333722-ndth5zne	197	16	treatment	treatment	NN
cord-333722-ndth5zne	197	17	of	of	IN
cord-333722-ndth5zne	197	18	severe	severe	JJ
cord-333722-ndth5zne	197	19	influenza	influenza	NN
cord-333722-ndth5zne	197	20	.	.	.
cord-333722-ndth5zne	198	1	Some	some	DT
cord-333722-ndth5zne	198	2	inexpensive	inexpensive	JJ
cord-333722-ndth5zne	198	3	generics	generic	NNS
cord-333722-ndth5zne	198	4	,	,	,
cord-333722-ndth5zne	198	5	such	such	JJ
cord-333722-ndth5zne	198	6	as	as	IN
cord-333722-ndth5zne	198	7	statins	statin	NNS
cord-333722-ndth5zne	198	8	,	,	,
cord-333722-ndth5zne	198	9	angiotensin	angiotensin	NN
cord-333722-ndth5zne	198	10	receptor	receptor	NN
cord-333722-ndth5zne	198	11	blockers	blocker	NNS
cord-333722-ndth5zne	198	12	(	(	-LRB-
cord-333722-ndth5zne	198	13	ARBs	arb	NNS
cord-333722-ndth5zne	198	14	)	)	-RRB-
cord-333722-ndth5zne	198	15	,	,	,
cord-333722-ndth5zne	198	16	and	and	CC
cord-333722-ndth5zne	198	17	angiotensin	angiotensin	NN
cord-333722-ndth5zne	198	18	-	-	HYPH
cord-333722-ndth5zne	198	19	converting	convert	VBG
cord-333722-ndth5zne	198	20	enzyme	enzyme	NN
cord-333722-ndth5zne	198	21	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	198	22	(	(	-LRB-
cord-333722-ndth5zne	198	23	ACEIs	acei	NNS
cord-333722-ndth5zne	198	24	)	)	-RRB-
cord-333722-ndth5zne	198	25	,	,	,
cord-333722-ndth5zne	198	26	were	be	VBD
cord-333722-ndth5zne	198	27	also	also	RB
cord-333722-ndth5zne	198	28	proposed	propose	VBN
cord-333722-ndth5zne	198	29	as	as	IN
cord-333722-ndth5zne	198	30	potential	potential	JJ
cord-333722-ndth5zne	198	31	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	198	32	agents	agent	NNS
cord-333722-ndth5zne	198	33	to	to	TO
cord-333722-ndth5zne	198	34	reduce	reduce	VB
cord-333722-ndth5zne	198	35	inflammation	inflammation	NN
cord-333722-ndth5zne	198	36	caused	cause	VBN
cord-333722-ndth5zne	198	37	by	by	IN
cord-333722-ndth5zne	198	38	the	the	DT
cord-333722-ndth5zne	198	39	influenza	influenza	NN
cord-333722-ndth5zne	198	40	virus	virus	NN
cord-333722-ndth5zne	198	41	.	.	.
cord-333722-ndth5zne	199	1	53	53	CD
cord-333722-ndth5zne	199	2	Statins	statin	NNS
cord-333722-ndth5zne	199	3	are	be	VBP
cord-333722-ndth5zne	199	4	competitive	competitive	JJ
cord-333722-ndth5zne	199	5	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	199	6	of	of	IN
cord-333722-ndth5zne	199	7	the	the	DT
cord-333722-ndth5zne	199	8	enzyme	enzyme	NN
cord-333722-ndth5zne	199	9	3hydroxy-3-methylglutaryl	3hydroxy-3-methylglutaryl	CD
cord-333722-ndth5zne	199	10	coenzyme	coenzyme	VBZ
cord-333722-ndth5zne	199	11	A	A	NNP
cord-333722-ndth5zne	199	12	(	(	-LRB-
cord-333722-ndth5zne	199	13	HMG	HMG	NNP
cord-333722-ndth5zne	199	14	-	-	HYPH
cord-333722-ndth5zne	199	15	CoA	CoA	NNP
cord-333722-ndth5zne	199	16	)	)	-RRB-
cord-333722-ndth5zne	199	17	reductase	reductase	NN
cord-333722-ndth5zne	199	18	.	.	.
cord-333722-ndth5zne	200	1	They	-PRON-	PRP
cord-333722-ndth5zne	200	2	exert	exert	VBP
cord-333722-ndth5zne	200	3	multiple	multiple	JJ
cord-333722-ndth5zne	200	4	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	200	5	effects	effect	NNS
cord-333722-ndth5zne	200	6	,	,	,
cord-333722-ndth5zne	200	7	such	such	JJ
cord-333722-ndth5zne	200	8	as	as	IN
cord-333722-ndth5zne	200	9	(	(	-LRB-
cord-333722-ndth5zne	200	10	i	i	NN
cord-333722-ndth5zne	200	11	)	)	-RRB-
cord-333722-ndth5zne	200	12	modulating	modulate	VBG
cord-333722-ndth5zne	200	13	the	the	DT
cord-333722-ndth5zne	200	14	activation	activation	NN
cord-333722-ndth5zne	200	15	of	of	IN
cord-333722-ndth5zne	200	16	immune	immune	JJ
cord-333722-ndth5zne	200	17	effector	effector	NN
cord-333722-ndth5zne	200	18	cells	cell	NNS
cord-333722-ndth5zne	200	19	via	via	IN
cord-333722-ndth5zne	200	20	inhibition	inhibition	NN
cord-333722-ndth5zne	200	21	of	of	IN
cord-333722-ndth5zne	200	22	ROS	ROS	NNP
cord-333722-ndth5zne	200	23	,	,	,
cord-333722-ndth5zne	200	24	(	(	-LRB-
cord-333722-ndth5zne	200	25	ii	ii	NN
cord-333722-ndth5zne	200	26	)	)	-RRB-
cord-333722-ndth5zne	200	27	antagonizing	antagonize	VBG
cord-333722-ndth5zne	200	28	high	high	JJ
cord-333722-ndth5zne	200	29	mobility	mobility	NN
cord-333722-ndth5zne	200	30	group	group	NN
cord-333722-ndth5zne	200	31	box	box	NN
cord-333722-ndth5zne	200	32	1	1	CD
cord-333722-ndth5zne	200	33	protein	protein	NN
cord-333722-ndth5zne	200	34	(	(	-LRB-
cord-333722-ndth5zne	200	35	HMGB1	HMGB1	NNP
cord-333722-ndth5zne	200	36	)	)	-RRB-
cord-333722-ndth5zne	200	37	to	to	TO
cord-333722-ndth5zne	200	38	inhibit	inhibit	VB
cord-333722-ndth5zne	200	39	pro	pro	JJ
cord-333722-ndth5zne	200	40	-	-	JJ
cord-333722-ndth5zne	200	41	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	200	42	cytokine	cytokine	NN
cord-333722-ndth5zne	200	43	expression	expression	NN
cord-333722-ndth5zne	200	44	,	,	,
cord-333722-ndth5zne	200	45	and	and	CC
cord-333722-ndth5zne	200	46	(	(	-LRB-
cord-333722-ndth5zne	200	47	iii	iii	NN
cord-333722-ndth5zne	200	48	)	)	-RRB-
cord-333722-ndth5zne	200	49	suppressing	suppress	VBG
cord-333722-ndth5zne	200	50	CCR2	CCR2	NNP
cord-333722-ndth5zne	200	51	gene	gene	NN
cord-333722-ndth5zne	200	52	expression	expression	NN
cord-333722-ndth5zne	200	53	.	.	.
cord-333722-ndth5zne	201	1	53	53	CD
cord-333722-ndth5zne	202	1	In	in	IN
cord-333722-ndth5zne	202	2	murine	murine	JJ
cord-333722-ndth5zne	202	3	models	model	NNS
cord-333722-ndth5zne	202	4	infected	infect	VBN
cord-333722-ndth5zne	202	5	with	with	IN
cord-333722-ndth5zne	202	6	H1N1	H1N1	NNP
cord-333722-ndth5zne	202	7	,	,	,
cord-333722-ndth5zne	202	8	H3N2	H3N2	NNP
cord-333722-ndth5zne	202	9	,	,	,
cord-333722-ndth5zne	202	10	or	or	CC
cord-333722-ndth5zne	202	11	H5N1	H5N1	NNP
cord-333722-ndth5zne	202	12	influenza	influenza	NN
cord-333722-ndth5zne	202	13	virus	virus	NN
cord-333722-ndth5zne	202	14	,	,	,
cord-333722-ndth5zne	202	15	the	the	DT
cord-333722-ndth5zne	202	16	combination	combination	NN
cord-333722-ndth5zne	202	17	of	of	IN
cord-333722-ndth5zne	202	18	statins	statin	NNS
cord-333722-ndth5zne	202	19	and	and	CC
cord-333722-ndth5zne	202	20	caffeine	caffeine	NN
cord-333722-ndth5zne	202	21	alleviated	alleviate	VBD
cord-333722-ndth5zne	202	22	the	the	DT
cord-333722-ndth5zne	202	23	lung	lung	NN
cord-333722-ndth5zne	202	24	injury	injury	NN
cord-333722-ndth5zne	202	25	,	,	,
cord-333722-ndth5zne	202	26	inhibited	inhibited	JJ
cord-333722-ndth5zne	202	27	viral	viral	JJ
cord-333722-ndth5zne	202	28	replication	replication	NN
cord-333722-ndth5zne	202	29	,	,	,
cord-333722-ndth5zne	202	30	and	and	CC
cord-333722-ndth5zne	202	31	appeared	appear	VBD
cord-333722-ndth5zne	202	32	to	to	TO
cord-333722-ndth5zne	202	33	have	have	VB
cord-333722-ndth5zne	202	34	similar	similar	JJ
cord-333722-ndth5zne	202	35	efficacy	efficacy	NN
cord-333722-ndth5zne	202	36	as	as	IN
cord-333722-ndth5zne	202	37	oseltamivir	oseltamivir	FW
cord-333722-ndth5zne	202	38	or	or	CC
cord-333722-ndth5zne	202	39	ribavirin	ribavirin	NN
cord-333722-ndth5zne	202	40	.	.	.
cord-333722-ndth5zne	203	1	54	54	CD
cord-333722-ndth5zne	204	1	However	however	RB
cord-333722-ndth5zne	204	2	,	,	,
cord-333722-ndth5zne	204	3	an	an	DT
cord-333722-ndth5zne	204	4	independent	independent	JJ
cord-333722-ndth5zne	204	5	research	research	NN
cord-333722-ndth5zne	204	6	study	study	NN
cord-333722-ndth5zne	204	7	showed	show	VBD
cord-333722-ndth5zne	204	8	that	that	IN
cord-333722-ndth5zne	204	9	statins	statin	NNS
cord-333722-ndth5zne	204	10	can	can	MD
cord-333722-ndth5zne	204	11	not	not	RB
cord-333722-ndth5zne	204	12	prevent	prevent	VB
cord-333722-ndth5zne	204	13	patients	patient	NNS
cord-333722-ndth5zne	204	14	infected	infect	VBN
cord-333722-ndth5zne	204	15	with	with	IN
cord-333722-ndth5zne	204	16	the	the	DT
cord-333722-ndth5zne	204	17	2009	2009	CD
cord-333722-ndth5zne	204	18	H1N1	H1N1	NNP
cord-333722-ndth5zne	204	19	pandemic	pandemic	NN
cord-333722-ndth5zne	204	20	influenza	influenza	NN
cord-333722-ndth5zne	204	21	from	from	IN
cord-333722-ndth5zne	204	22	developing	develop	VBG
cord-333722-ndth5zne	204	23	severe	severe	JJ
cord-333722-ndth5zne	204	24	disease	disease	NN
cord-333722-ndth5zne	204	25	.	.	.
cord-333722-ndth5zne	205	1	55	55	CD
cord-333722-ndth5zne	206	1	No	no	DT
cord-333722-ndth5zne	206	2	direct	direct	JJ
cord-333722-ndth5zne	206	3	evidence	evidence	NN
cord-333722-ndth5zne	206	4	was	be	VBD
cord-333722-ndth5zne	206	5	shown	show	VBN
cord-333722-ndth5zne	206	6	that	that	IN
cord-333722-ndth5zne	206	7	ACEIs	acei	NNS
cord-333722-ndth5zne	206	8	or	or	CC
cord-333722-ndth5zne	206	9	ARBs	arb	NNS
cord-333722-ndth5zne	206	10	might	may	MD
cord-333722-ndth5zne	206	11	be	be	VB
cord-333722-ndth5zne	206	12	effective	effective	JJ
cord-333722-ndth5zne	206	13	in	in	IN
cord-333722-ndth5zne	206	14	the	the	DT
cord-333722-ndth5zne	206	15	therapy	therapy	NN
cord-333722-ndth5zne	206	16	of	of	IN
cord-333722-ndth5zne	206	17	severe	severe	JJ
cord-333722-ndth5zne	206	18	influenza	influenza	NN
cord-333722-ndth5zne	206	19	-	-	HYPH
cord-333722-ndth5zne	206	20	induced	induce	VBN
cord-333722-ndth5zne	206	21	cytokine	cytokine	NN
cord-333722-ndth5zne	206	22	storm	storm	NN
cord-333722-ndth5zne	206	23	.	.	.
cord-333722-ndth5zne	207	1	However	however	RB
cord-333722-ndth5zne	207	2	,	,	,
cord-333722-ndth5zne	207	3	these	these	DT
cord-333722-ndth5zne	207	4	agents	agent	NNS
cord-333722-ndth5zne	207	5	can	can	MD
cord-333722-ndth5zne	207	6	inhibit	inhibit	VB
cord-333722-ndth5zne	207	7	the	the	DT
cord-333722-ndth5zne	207	8	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	207	9	response	response	NN
cord-333722-ndth5zne	207	10	induced	induce	VBN
cord-333722-ndth5zne	207	11	by	by	IN
cord-333722-ndth5zne	207	12	angiotensin	angiotensin	NN
cord-333722-ndth5zne	207	13	II	II	NNP
cord-333722-ndth5zne	207	14	and	and	CC
cord-333722-ndth5zne	207	15	improve	improve	VB
cord-333722-ndth5zne	207	16	the	the	DT
cord-333722-ndth5zne	207	17	survival	survival	NN
cord-333722-ndth5zne	207	18	of	of	IN
cord-333722-ndth5zne	207	19	mice	mouse	NNS
cord-333722-ndth5zne	207	20	in	in	IN
cord-333722-ndth5zne	207	21	several	several	JJ
cord-333722-ndth5zne	207	22	experimental	experimental	JJ
cord-333722-ndth5zne	207	23	models	model	NNS
cord-333722-ndth5zne	207	24	of	of	IN
cord-333722-ndth5zne	207	25	acute	acute	JJ
cord-333722-ndth5zne	207	26	lung	lung	NN
cord-333722-ndth5zne	207	27	injury	injury	NN
cord-333722-ndth5zne	207	28	.	.	.
cord-333722-ndth5zne	208	1	56	56	CD
cord-333722-ndth5zne	209	1	Furthermore	furthermore	RB
cord-333722-ndth5zne	209	2	,	,	,
cord-333722-ndth5zne	209	3	clinical	clinical	JJ
cord-333722-ndth5zne	209	4	trials	trial	NNS
cord-333722-ndth5zne	209	5	also	also	RB
cord-333722-ndth5zne	209	6	confirmed	confirm	VBD
cord-333722-ndth5zne	209	7	that	that	IN
cord-333722-ndth5zne	209	8	these	these	DT
cord-333722-ndth5zne	209	9	agents	agent	NNS
cord-333722-ndth5zne	209	10	can	can	MD
cord-333722-ndth5zne	209	11	reduce	reduce	VB
cord-333722-ndth5zne	209	12	the	the	DT
cord-333722-ndth5zne	209	13	risk	risk	NN
cord-333722-ndth5zne	209	14	of	of	IN
cord-333722-ndth5zne	209	15	pneumonia	pneumonia	NN
cord-333722-ndth5zne	209	16	and	and	CC
cord-333722-ndth5zne	209	17	pneumonia	pneumonia	NN
cord-333722-ndth5zne	209	18	-	-	HYPH
cord-333722-ndth5zne	209	19	related	relate	VBN
cord-333722-ndth5zne	209	20	mortality	mortality	NN
cord-333722-ndth5zne	209	21	.	.	.
cord-333722-ndth5zne	210	1	57	57	CD
cord-333722-ndth5zne	211	1	Thus	thus	RB
cord-333722-ndth5zne	211	2	,	,	,
cord-333722-ndth5zne	211	3	both	both	CC
cord-333722-ndth5zne	211	4	the	the	DT
cord-333722-ndth5zne	211	5	pharmacodynamic	pharmacodynamic	JJ
cord-333722-ndth5zne	211	6	effects	effect	NNS
cord-333722-ndth5zne	211	7	and	and	CC
cord-333722-ndth5zne	211	8	mechanisms	mechanism	NNS
cord-333722-ndth5zne	211	9	of	of	IN
cord-333722-ndth5zne	211	10	these	these	DT
cord-333722-ndth5zne	211	11	generics	generic	NNS
cord-333722-ndth5zne	211	12	deserve	deserve	VBP
cord-333722-ndth5zne	211	13	further	further	JJ
cord-333722-ndth5zne	211	14	research	research	NN
cord-333722-ndth5zne	211	15	.	.	.
cord-333722-ndth5zne	212	1	30	30	CD
cord-333722-ndth5zne	212	2	Ineffective	ineffective	JJ
cord-333722-ndth5zne	212	3	as	as	IN
cord-333722-ndth5zne	212	4	monotherapy	monotherapy	NN
cord-333722-ndth5zne	212	5	in	in	IN
cord-333722-ndth5zne	212	6	H5N1	H5N1	NNP
cord-333722-ndth5zne	212	7	influenza	influenza	NN
cord-333722-ndth5zne	212	8	-	-	HYPH
cord-333722-ndth5zne	212	9	infected	infect	VBN
cord-333722-ndth5zne	212	10	mice	mouse	NNS
cord-333722-ndth5zne	212	11	.	.	.
cord-333722-ndth5zne	213	1	29	29	CD
cord-333722-ndth5zne	213	2	Increased	increase	VBN
cord-333722-ndth5zne	213	3	long	long	JJ
cord-333722-ndth5zne	213	4	-	-	HYPH
cord-333722-ndth5zne	213	5	term	term	NN
cord-333722-ndth5zne	213	6	mortality	mortality	NN
cord-333722-ndth5zne	213	7	in	in	IN
cord-333722-ndth5zne	213	8	influenza	influenza	NN
cord-333722-ndth5zne	213	9	-	-	HYPH
cord-333722-ndth5zne	213	10	infected	infect	VBN
cord-333722-ndth5zne	213	11	patients	patient	NNS
cord-333722-ndth5zne	213	12	with	with	IN
cord-333722-ndth5zne	213	13	pneumonia	pneumonia	NN
cord-333722-ndth5zne	213	14	.	.	.
cord-333722-ndth5zne	214	1	27	27	CD
cord-333722-ndth5zne	214	2	 	 	_SP
cord-333722-ndth5zne	215	1	Ciglitazone	Ciglitazone	NNP
cord-333722-ndth5zne	215	2	and	and	CC
cord-333722-ndth5zne	215	3	troglitazone	troglitazone	NN
cord-333722-ndth5zne	215	4	decreased	decrease	VBD
cord-333722-ndth5zne	215	5	the	the	DT
cord-333722-ndth5zne	215	6	mortality	mortality	NN
cord-333722-ndth5zne	215	7	of	of	IN
cord-333722-ndth5zne	215	8	influenza	influenza	NN
cord-333722-ndth5zne	215	9	-	-	HYPH
cord-333722-ndth5zne	215	10	infected	infect	VBN
cord-333722-ndth5zne	215	11	mice	mouse	NNS
cord-333722-ndth5zne	215	12	.	.	.
cord-333722-ndth5zne	216	1	34	34	CD
cord-333722-ndth5zne	217	1	Bezafibrate	Bezafibrate	NNP
cord-333722-ndth5zne	217	2	partially	partially	RB
cord-333722-ndth5zne	217	3	protected	protect	VBD
cord-333722-ndth5zne	217	4	patients	patient	NNS
cord-333722-ndth5zne	217	5	with	with	IN
cord-333722-ndth5zne	217	6	influenza	influenza	NN
cord-333722-ndth5zne	217	7	-	-	HYPH
cord-333722-ndth5zne	217	8	associated	associate	VBN
cord-333722-ndth5zne	217	9	encephalopathy	encephalopathy	NN
cord-333722-ndth5zne	217	10	.	.	.
cord-333722-ndth5zne	218	1	33	33	CD
cord-333722-ndth5zne	218	2	Gemfibrozil	Gemfibrozil	NNS
cord-333722-ndth5zne	218	3	also	also	RB
cord-333722-ndth5zne	218	4	decreased	decrease	VBD
cord-333722-ndth5zne	218	5	the	the	DT
cord-333722-ndth5zne	218	6	production	production	NN
cord-333722-ndth5zne	218	7	of	of	IN
cord-333722-ndth5zne	218	8	IL-1	IL-1	NNP
cord-333722-ndth5zne	218	9	,	,	,
cord-333722-ndth5zne	218	10	IL-6	IL-6	NNP
cord-333722-ndth5zne	218	11	,	,	,
cord-333722-ndth5zne	218	12	and	and	CC
cord-333722-ndth5zne	218	13	IFN	IFN	NNP
cord-333722-ndth5zne	218	14	-	-	HYPH
cord-333722-ndth5zne	218	15	c	c	NNP
cord-333722-ndth5zne	218	16	,	,	,
cord-333722-ndth5zne	218	17	but	but	CC
cord-333722-ndth5zne	218	18	has	have	VBZ
cord-333722-ndth5zne	218	19	no	no	DT
cord-333722-ndth5zne	218	20	effects	effect	NNS
cord-333722-ndth5zne	218	21	on	on	IN
cord-333722-ndth5zne	218	22	the	the	DT
cord-333722-ndth5zne	218	23	mortality	mortality	NN
cord-333722-ndth5zne	218	24	of	of	IN
cord-333722-ndth5zne	218	25	H5N1-infected	h5n1-infected	JJ
cord-333722-ndth5zne	218	26	mice	mouse	NNS
cord-333722-ndth5zne	218	27	when	when	WRB
cord-333722-ndth5zne	218	28	administered	administer	VBN
cord-333722-ndth5zne	218	29	48-h	48-h	CD
cord-333722-ndth5zne	218	30	post	post	NN
cord-333722-ndth5zne	218	31	-	-	NN
cord-333722-ndth5zne	218	32	infection	infection	NN
cord-333722-ndth5zne	218	33	.	.	.
cord-333722-ndth5zne	219	1	31,32	31,32	CD
cord-333722-ndth5zne	219	2	S1P1	S1P1	NNP
cord-333722-ndth5zne	219	3	receptor	receptor	NN
cord-333722-ndth5zne	219	4	1	1	CD
cord-333722-ndth5zne	219	5	agonists	agonist	NNS
cord-333722-ndth5zne	220	1	Reduced	reduce	VBN
cord-333722-ndth5zne	220	2	mortality	mortality	NN
cord-333722-ndth5zne	220	3	of	of	IN
cord-333722-ndth5zne	220	4	2009	2009	CD
cord-333722-ndth5zne	220	5	pandemic	pandemic	NN
cord-333722-ndth5zne	220	6	H1N1	H1N1	NNP
cord-333722-ndth5zne	220	7	influenza	influenza	NN
cord-333722-ndth5zne	220	8	-	-	HYPH
cord-333722-ndth5zne	220	9	infected	infect	VBN
cord-333722-ndth5zne	220	10	mice	mouse	NNS
cord-333722-ndth5zne	220	11	over	over	IN
cord-333722-ndth5zne	220	12	80	80	CD
cord-333722-ndth5zne	220	13	%	%	NN
cord-333722-ndth5zne	220	14	,	,	,
cord-333722-ndth5zne	220	15	compared	compare	VBN
cord-333722-ndth5zne	220	16	with	with	IN
cord-333722-ndth5zne	220	17	50	50	CD
cord-333722-ndth5zne	220	18	%	%	NN
cord-333722-ndth5zne	220	19	protection	protection	NN
cord-333722-ndth5zne	220	20	of	of	IN
cord-333722-ndth5zne	220	21	oseltamivir	oseltamivir	NNP
cord-333722-ndth5zne	220	22	.	.	.
cord-333722-ndth5zne	221	1	36	36	CD
cord-333722-ndth5zne	221	2	 	 	_SP
cord-333722-ndth5zne	221	3	Ineffective	Ineffective	NNP
cord-333722-ndth5zne	221	4	as	as	IN
cord-333722-ndth5zne	221	5	monotherapy	monotherapy	NN
cord-333722-ndth5zne	221	6	in	in	IN
cord-333722-ndth5zne	221	7	H5N1	H5N1	NNP
cord-333722-ndth5zne	221	8	influenza	influenza	NN
cord-333722-ndth5zne	221	9	-	-	HYPH
cord-333722-ndth5zne	221	10	infected	infect	VBN
cord-333722-ndth5zne	221	11	mice	mouse	NNS
cord-333722-ndth5zne	221	12	,	,	,
cord-333722-ndth5zne	221	13	while	while	IN
cord-333722-ndth5zne	221	14	effective	effective	JJ
cord-333722-ndth5zne	221	15	when	when	WRB
cord-333722-ndth5zne	221	16	in	in	IN
cord-333722-ndth5zne	221	17	combination	combination	NN
cord-333722-ndth5zne	221	18	with	with	IN
cord-333722-ndth5zne	221	19	neuraminidase	neuraminidase	NN
cord-333722-ndth5zne	221	20	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	221	21	.	.	.
cord-333722-ndth5zne	222	1	32	32	CD
cord-333722-ndth5zne	222	2	Antioxidants	antioxidant	NNS
cord-333722-ndth5zne	222	3	N	n	NN
cord-333722-ndth5zne	222	4	-	-	HYPH
cord-333722-ndth5zne	222	5	acetylcysteine	acetylcysteine	NN
cord-333722-ndth5zne	222	6	and	and	CC
cord-333722-ndth5zne	222	7	glycyrrhizin	glycyrrhizin	NNP
cord-333722-ndth5zne	222	8	inhibited	inhibit	VBD
cord-333722-ndth5zne	222	9	H5N1	H5N1	NNP
cord-333722-ndth5zne	222	10	replication	replication	NN
cord-333722-ndth5zne	222	11	and	and	CC
cord-333722-ndth5zne	222	12	pro	pro	JJ
cord-333722-ndth5zne	222	13	-	-	JJ
cord-333722-ndth5zne	222	14	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	222	15	gene	gene	NN
cord-333722-ndth5zne	222	16	expression	expression	NN
cord-333722-ndth5zne	222	17	in	in	IN
cord-333722-ndth5zne	222	18	vitro	vitro	FW
cord-333722-ndth5zne	222	19	39,40	39,40	CD
cord-333722-ndth5zne	222	20	but	but	CC
cord-333722-ndth5zne	222	21	ineffective	ineffective	JJ
cord-333722-ndth5zne	222	22	as	as	IN
cord-333722-ndth5zne	222	23	monotherapy	monotherapy	NN
cord-333722-ndth5zne	222	24	in	in	IN
cord-333722-ndth5zne	222	25	vivo	vivo	NNP
cord-333722-ndth5zne	222	26	.	.	.
cord-333722-ndth5zne	223	1	45	45	CD
cord-333722-ndth5zne	223	2	 	 	_SP
cord-333722-ndth5zne	223	3	Effective	Effective	NNP
cord-333722-ndth5zne	223	4	in	in	IN
cord-333722-ndth5zne	223	5	reducing	reduce	VBG
cord-333722-ndth5zne	223	6	the	the	DT
cord-333722-ndth5zne	223	7	cytokine	cytokine	NN
cord-333722-ndth5zne	223	8	production	production	NN
cord-333722-ndth5zne	223	9	and	and	CC
cord-333722-ndth5zne	223	10	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	223	11	cell	cell	NN
cord-333722-ndth5zne	223	12	infiltrates	infiltrate	VBZ
cord-333722-ndth5zne	223	13	in	in	IN
cord-333722-ndth5zne	223	14	influenza	influenza	NN
cord-333722-ndth5zne	223	15	-	-	HYPH
cord-333722-ndth5zne	223	16	infected	infect	VBN
cord-333722-ndth5zne	223	17	murine	murine	JJ
cord-333722-ndth5zne	223	18	lung	lung	NN
cord-333722-ndth5zne	223	19	but	but	CC
cord-333722-ndth5zne	223	20	ineffective	ineffective	JJ
cord-333722-ndth5zne	223	21	in	in	IN
cord-333722-ndth5zne	223	22	improving	improve	VBG
cord-333722-ndth5zne	223	23	survival	survival	NN
cord-333722-ndth5zne	223	24	of	of	IN
cord-333722-ndth5zne	223	25	infected	infected	JJ
cord-333722-ndth5zne	223	26	mice	mouse	NNS
cord-333722-ndth5zne	223	27	.	.	.
cord-333722-ndth5zne	224	1	47	47	CD
cord-333722-ndth5zne	225	1	Combined	combine	VBN
cord-333722-ndth5zne	225	2	with	with	IN
cord-333722-ndth5zne	225	3	caffeine	caffeine	NN
cord-333722-ndth5zne	225	4	or	or	CC
cord-333722-ndth5zne	225	5	antivirals	antiviral	NNS
cord-333722-ndth5zne	225	6	,	,	,
cord-333722-ndth5zne	225	7	alleviated	alleviate	VBD
cord-333722-ndth5zne	225	8	lung	lung	NN
cord-333722-ndth5zne	225	9	injury	injury	NN
cord-333722-ndth5zne	225	10	and	and	CC
cord-333722-ndth5zne	225	11	inhibited	inhibit	VBN
cord-333722-ndth5zne	225	12	viral	viral	JJ
cord-333722-ndth5zne	225	13	replication	replication	NN
cord-333722-ndth5zne	225	14	in	in	IN
cord-333722-ndth5zne	225	15	H1N1	H1N1	NNP
cord-333722-ndth5zne	225	16	,	,	,
cord-333722-ndth5zne	225	17	H3N2	H3N2	NNP
cord-333722-ndth5zne	225	18	,	,	,
cord-333722-ndth5zne	225	19	and	and	CC
cord-333722-ndth5zne	225	20	H5N1	H5N1	NNP
cord-333722-ndth5zne	225	21	influenza	influenza	NN
cord-333722-ndth5zne	225	22	-	-	HYPH
cord-333722-ndth5zne	225	23	infected	infect	VBN
cord-333722-ndth5zne	225	24	mice	mouse	NNS
cord-333722-ndth5zne	225	25	.	.	.
cord-333722-ndth5zne	226	1	54	54	CD
cord-333722-ndth5zne	227	1	Ineffective	ineffective	JJ
cord-333722-ndth5zne	227	2	in	in	IN
cord-333722-ndth5zne	227	3	protecting	protect	VBG
cord-333722-ndth5zne	227	4	2009	2009	CD
cord-333722-ndth5zne	227	5	pandemic	pandemic	NN
cord-333722-ndth5zne	227	6	H1N1-infected	h1n1-infecte	VBN
cord-333722-ndth5zne	227	7	patients	patient	NNS
cord-333722-ndth5zne	227	8	.	.	.
cord-333722-ndth5zne	228	1	55	55	CD
cord-333722-ndth5zne	228	2	 	 	_SP
cord-333722-ndth5zne	228	3	Increased	increase	VBN
cord-333722-ndth5zne	228	4	survival	survival	NN
cord-333722-ndth5zne	228	5	of	of	IN
cord-333722-ndth5zne	228	6	influenza	influenza	NN
cord-333722-ndth5zne	228	7	-	-	HYPH
cord-333722-ndth5zne	228	8	infected	infect	VBN
cord-333722-ndth5zne	228	9	mice	mouse	NNS
cord-333722-ndth5zne	228	10	by	by	IN
cord-333722-ndth5zne	228	11	75	75	CD
cord-333722-ndth5zne	228	12	%	%	NN
cord-333722-ndth5zne	228	13	.	.	.
cord-333722-ndth5zne	229	1	58	58	CD
cord-333722-ndth5zne	229	2	 	 	_SP
cord-333722-ndth5zne	230	1	Increased	increase	VBN
cord-333722-ndth5zne	230	2	survival	survival	NN
cord-333722-ndth5zne	230	3	for	for	IN
cord-333722-ndth5zne	230	4	influenza	influenza	NN
cord-333722-ndth5zne	230	5	-	-	HYPH
cord-333722-ndth5zne	230	6	infected	infect	VBN
cord-333722-ndth5zne	230	7	mice	mouse	NNS
cord-333722-ndth5zne	230	8	by	by	IN
cord-333722-ndth5zne	230	9	40	40	CD
cord-333722-ndth5zne	230	10	%	%	NN
cord-333722-ndth5zne	230	11	,	,	,
cord-333722-ndth5zne	230	12	while	while	IN
cord-333722-ndth5zne	230	13	a	a	DT
cord-333722-ndth5zne	230	14	combination	combination	NN
cord-333722-ndth5zne	230	15	with	with	IN
cord-333722-ndth5zne	230	16	pioglitazone	pioglitazone	NN
cord-333722-ndth5zne	230	17	improved	improve	VBN
cord-333722-ndth5zne	230	18	survival	survival	NN
cord-333722-ndth5zne	230	19	by	by	IN
cord-333722-ndth5zne	230	20	60	60	CD
cord-333722-ndth5zne	230	21	%	%	NN
cord-333722-ndth5zne	230	22	.	.	.
cord-333722-ndth5zne	231	1	59	59	CD
cord-333722-ndth5zne	231	2	OX40	OX40	NNP
cord-333722-ndth5zne	231	3	Imparted	impart	VBD
cord-333722-ndth5zne	231	4	a	a	DT
cord-333722-ndth5zne	231	5	survival	survival	NN
cord-333722-ndth5zne	231	6	signal	signal	NN
cord-333722-ndth5zne	231	7	to	to	IN
cord-333722-ndth5zne	231	8	the	the	DT
cord-333722-ndth5zne	231	9	T	T	NNP
cord-333722-ndth5zne	231	10	cell	cell	NN
cord-333722-ndth5zne	231	11	via	via	IN
cord-333722-ndth5zne	231	12	upregulating	upregulate	VBG
cord-333722-ndth5zne	231	13	anti	anti	JJ
cord-333722-ndth5zne	231	14	-	-	JJ
cord-333722-ndth5zne	231	15	apoptosis	apoptosis	JJ
cord-333722-ndth5zne	231	16	gene	gene	NN
cord-333722-ndth5zne	231	17	expression	expression	NN
cord-333722-ndth5zne	231	18	and	and	CC
cord-333722-ndth5zne	231	19	eliminated	eliminate	VBD
cord-333722-ndth5zne	231	20	weight	weight	NN
cord-333722-ndth5zne	231	21	loss	loss	NN
cord-333722-ndth5zne	231	22	in	in	IN
cord-333722-ndth5zne	231	23	influenza	influenza	NN
cord-333722-ndth5zne	231	24	-	-	HYPH
cord-333722-ndth5zne	231	25	infected	infect	VBN
cord-333722-ndth5zne	231	26	mice	mouse	NNS
cord-333722-ndth5zne	231	27	.	.	.
cord-333722-ndth5zne	232	1	60	60	CD
cord-333722-ndth5zne	232	2	 	 	_SP
cord-333722-ndth5zne	233	1	Participated	participate	VBN
cord-333722-ndth5zne	233	2	in	in	IN
cord-333722-ndth5zne	233	3	a	a	DT
cord-333722-ndth5zne	233	4	negative	negative	JJ
cord-333722-ndth5zne	233	5	feedback	feedback	NN
cord-333722-ndth5zne	233	6	loop	loop	NN
cord-333722-ndth5zne	233	7	in	in	IN
cord-333722-ndth5zne	233	8	the	the	DT
cord-333722-ndth5zne	233	9	JAK	JAK	NNP
cord-333722-ndth5zne	233	10	and	and	CC
cord-333722-ndth5zne	233	11	epidermal	epidermal	JJ
cord-333722-ndth5zne	233	12	growth	growth	NN
cord-333722-ndth5zne	233	13	factor	factor	NN
cord-333722-ndth5zne	233	14	receptor	receptor	NN
cord-333722-ndth5zne	233	15	pathway	pathway	NN
cord-333722-ndth5zne	233	16	to	to	TO
cord-333722-ndth5zne	233	17	protect	protect	VB
cord-333722-ndth5zne	233	18	against	against	IN
cord-333722-ndth5zne	233	19	severe	severe	JJ
cord-333722-ndth5zne	233	20	cytokine	cytokine	NN
cord-333722-ndth5zne	233	21	storm	storm	NN
cord-333722-ndth5zne	233	22	during	during	IN
cord-333722-ndth5zne	233	23	severe	severe	JJ
cord-333722-ndth5zne	233	24	influenza	influenza	NN
cord-333722-ndth5zne	233	25	.	.	.
cord-333722-ndth5zne	234	1	61	61	CD
cord-333722-ndth5zne	234	2	 	 	_SP
cord-333722-ndth5zne	235	1	Decreased	decrease	VBN
cord-333722-ndth5zne	235	2	mortality	mortality	NN
cord-333722-ndth5zne	235	3	,	,	,
cord-333722-ndth5zne	235	4	pro	pro	JJ
cord-333722-ndth5zne	235	5	-	-	JJ
cord-333722-ndth5zne	235	6	inflammation	inflammation	JJ
cord-333722-ndth5zne	235	7	,	,	,
cord-333722-ndth5zne	235	8	and	and	CC
cord-333722-ndth5zne	235	9	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	235	10	cell	cell	NN
cord-333722-ndth5zne	235	11	counts	count	NNS
cord-333722-ndth5zne	235	12	of	of	IN
cord-333722-ndth5zne	235	13	influenza	influenza	NN
cord-333722-ndth5zne	235	14	-	-	HYPH
cord-333722-ndth5zne	235	15	infected	infect	VBN
cord-333722-ndth5zne	235	16	mice	mouse	NNS
cord-333722-ndth5zne	235	17	.	.	.
cord-333722-ndth5zne	236	1	62	62	CD
cord-333722-ndth5zne	236	2	 	 	_SP
cord-333722-ndth5zne	237	1	Reduced	reduce	VBN
cord-333722-ndth5zne	237	2	the	the	DT
cord-333722-ndth5zne	237	3	mortality	mortality	NN
cord-333722-ndth5zne	237	4	,	,	,
cord-333722-ndth5zne	237	5	lung	lung	NN
cord-333722-ndth5zne	237	6	lesion	lesion	NN
cord-333722-ndth5zne	237	7	formation	formation	NN
cord-333722-ndth5zne	237	8	,	,	,
cord-333722-ndth5zne	237	9	and	and	CC
cord-333722-ndth5zne	237	10	inflammation	inflammation	NN
cord-333722-ndth5zne	237	11	of	of	IN
cord-333722-ndth5zne	237	12	severe	severe	JJ
cord-333722-ndth5zne	237	13	influenza	influenza	NN
cord-333722-ndth5zne	237	14	-	-	HYPH
cord-333722-ndth5zne	237	15	infected	infect	VBN
cord-333722-ndth5zne	237	16	mice	mouse	NNS
cord-333722-ndth5zne	237	17	.	.	.
cord-333722-ndth5zne	238	1	64	64	CD
cord-333722-ndth5zne	238	2	 	 	_SP
cord-333722-ndth5zne	239	1	Favorable	favorable	JJ
cord-333722-ndth5zne	239	2	in	in	IN
cord-333722-ndth5zne	239	3	laboratorial	laboratorial	JJ
cord-333722-ndth5zne	239	4	data	datum	NNS
cord-333722-ndth5zne	239	5	but	but	CC
cord-333722-ndth5zne	239	6	limited	limited	JJ
cord-333722-ndth5zne	239	7	clinical	clinical	JJ
cord-333722-ndth5zne	239	8	data	datum	NNS
cord-333722-ndth5zne	239	9	for	for	IN
cord-333722-ndth5zne	239	10	severe	severe	JJ
cord-333722-ndth5zne	239	11	influenza	influenza	NN
cord-333722-ndth5zne	239	12	.	.	.
cord-333722-ndth5zne	240	1	[	[	-LRB-
cord-333722-ndth5zne	240	2	65	65	CD
cord-333722-ndth5zne	240	3	]	]	-RRB-
cord-333722-ndth5zne	240	4	[	[	-LRB-
cord-333722-ndth5zne	240	5	66	66	CD
cord-333722-ndth5zne	240	6	]	]	-RRB-
cord-333722-ndth5zne	241	1	[	[	-LRB-
cord-333722-ndth5zne	241	2	67	67	CD
cord-333722-ndth5zne	241	3	]	]	-RRB-
cord-333722-ndth5zne	242	1	[	[	-LRB-
cord-333722-ndth5zne	242	2	68	68	CD
cord-333722-ndth5zne	242	3	]	]	-RRB-
cord-333722-ndth5zne	242	4	[	[	-LRB-
cord-333722-ndth5zne	242	5	69	69	CD
cord-333722-ndth5zne	242	6	]	]	-RRB-
cord-333722-ndth5zne	242	7	[	[	-LRB-
cord-333722-ndth5zne	242	8	70	70	CD
cord-333722-ndth5zne	242	9	]	]	-RRB-
cord-333722-ndth5zne	242	10	[	[	-LRB-
cord-333722-ndth5zne	242	11	71	71	CD
cord-333722-ndth5zne	242	12	]	]	-RRB-
cord-333722-ndth5zne	243	1	Several	several	JJ
cord-333722-ndth5zne	243	2	other	other	JJ
cord-333722-ndth5zne	243	3	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	243	4	agents	agent	NNS
cord-333722-ndth5zne	243	5	are	be	VBP
cord-333722-ndth5zne	243	6	being	be	VBG
cord-333722-ndth5zne	243	7	assessed	assess	VBN
cord-333722-ndth5zne	243	8	for	for	IN
cord-333722-ndth5zne	243	9	their	-PRON-	PRP$
cord-333722-ndth5zne	243	10	efficacy	efficacy	NN
cord-333722-ndth5zne	243	11	,	,	,
cord-333722-ndth5zne	243	12	both	both	CC
cord-333722-ndth5zne	243	13	in	in	IN
cord-333722-ndth5zne	243	14	vitro	vitro	FW
cord-333722-ndth5zne	243	15	and	and	CC
cord-333722-ndth5zne	243	16	in	in	IN
cord-333722-ndth5zne	243	17	vivo	vivo	NNP
cord-333722-ndth5zne	243	18	.	.	.
cord-333722-ndth5zne	244	1	Lin	Lin	NNP
cord-333722-ndth5zne	244	2	and	and	CC
cord-333722-ndth5zne	244	3	colleagues	colleague	NNS
cord-333722-ndth5zne	244	4	58	58	CD
cord-333722-ndth5zne	244	5	have	have	VBP
cord-333722-ndth5zne	244	6	confirmed	confirm	VBN
cord-333722-ndth5zne	244	7	that	that	IN
cord-333722-ndth5zne	244	8	CCR	CCR	NNP
cord-333722-ndth5zne	244	9	inhibitor	inhibitor	NN
cord-333722-ndth5zne	244	10	-	-	HYPH
cord-333722-ndth5zne	244	11	treated	treat	VBN
cord-333722-ndth5zne	244	12	mice	mouse	NNS
cord-333722-ndth5zne	244	13	had	have	VBD
cord-333722-ndth5zne	244	14	a	a	DT
cord-333722-ndth5zne	244	15	significant	significant	JJ
cord-333722-ndth5zne	244	16	increase	increase	NN
cord-333722-ndth5zne	244	17	in	in	IN
cord-333722-ndth5zne	244	18	survival	survival	NN
cord-333722-ndth5zne	244	19	(	(	-LRB-
cord-333722-ndth5zne	244	20	75	75	CD
cord-333722-ndth5zne	244	21	%	%	NN
cord-333722-ndth5zne	244	22	versus	versus	IN
cord-333722-ndth5zne	244	23	placebo	placebo	NN
cord-333722-ndth5zne	244	24	)	)	-RRB-
cord-333722-ndth5zne	244	25	after	after	IN
cord-333722-ndth5zne	244	26	being	be	VBG
cord-333722-ndth5zne	244	27	infected	infect	VBN
cord-333722-ndth5zne	244	28	with	with	IN
cord-333722-ndth5zne	244	29	influenza	influenza	NN
cord-333722-ndth5zne	244	30	.	.	.
cord-333722-ndth5zne	245	1	Adenosine	adenosine	NN
cord-333722-ndth5zne	245	2	59-monophosphate	59-monophosphate	CD
cord-333722-ndth5zne	245	3	-	-	HYPH
cord-333722-ndth5zne	245	4	activated	activate	VBN
cord-333722-ndth5zne	245	5	protein	protein	NN
cord-333722-ndth5zne	245	6	kinase	kinase	NN
cord-333722-ndth5zne	245	7	(	(	-LRB-
cord-333722-ndth5zne	245	8	AMPK	AMPK	NNP
cord-333722-ndth5zne	245	9	)	)	-RRB-
cord-333722-ndth5zne	245	10	is	be	VBZ
cord-333722-ndth5zne	245	11	an	an	DT
cord-333722-ndth5zne	245	12	enzyme	enzyme	NN
cord-333722-ndth5zne	245	13	that	that	WDT
cord-333722-ndth5zne	245	14	exerts	exert	VBZ
cord-333722-ndth5zne	245	15	antiinflammatory	antiinflammatory	JJ
cord-333722-ndth5zne	245	16	effects	effect	NNS
cord-333722-ndth5zne	245	17	after	after	IN
cord-333722-ndth5zne	245	18	activation	activation	NN
cord-333722-ndth5zne	245	19	.	.	.
cord-333722-ndth5zne	246	1	The	the	DT
cord-333722-ndth5zne	246	2	AMPK	AMPK	NNP
cord-333722-ndth5zne	246	3	activator	activator	NN
cord-333722-ndth5zne	246	4	aminoimidazole	aminoimidazole	NN
cord-333722-ndth5zne	246	5	carboxamide	carboxamide	NNP
cord-333722-ndth5zne	246	6	ribonucleotide	ribonucleotide	NN
cord-333722-ndth5zne	246	7	(	(	-LRB-
cord-333722-ndth5zne	246	8	AICAR	AICAR	NNP
cord-333722-ndth5zne	246	9	)	)	-RRB-
cord-333722-ndth5zne	246	10	was	be	VBD
cord-333722-ndth5zne	246	11	reported	report	VBN
cord-333722-ndth5zne	246	12	to	to	TO
cord-333722-ndth5zne	246	13	increase	increase	VB
cord-333722-ndth5zne	246	14	survival	survival	NN
cord-333722-ndth5zne	246	15	by	by	IN
cord-333722-ndth5zne	246	16	40	40	CD
cord-333722-ndth5zne	246	17	%	%	NN
cord-333722-ndth5zne	246	18	in	in	IN
cord-333722-ndth5zne	246	19	influenza	influenza	NN
cord-333722-ndth5zne	246	20	-	-	HYPH
cord-333722-ndth5zne	246	21	infected	infect	VBN
cord-333722-ndth5zne	246	22	mice	mouse	NNS
cord-333722-ndth5zne	246	23	,	,	,
cord-333722-ndth5zne	246	24	while	while	IN
cord-333722-ndth5zne	246	25	combination	combination	NN
cord-333722-ndth5zne	246	26	with	with	IN
cord-333722-ndth5zne	246	27	pioglitazone	pioglitazone	NN
cord-333722-ndth5zne	246	28	improved	improve	VBN
cord-333722-ndth5zne	246	29	survival	survival	NN
cord-333722-ndth5zne	246	30	by	by	IN
cord-333722-ndth5zne	246	31	60	60	CD
cord-333722-ndth5zne	246	32	%	%	NN
cord-333722-ndth5zne	246	33	.	.	.
cord-333722-ndth5zne	247	1	59	59	CD
cord-333722-ndth5zne	247	2	OX40	OX40	NNP
cord-333722-ndth5zne	247	3	(	(	-LRB-
cord-333722-ndth5zne	247	4	CD134	cd134	NN
cord-333722-ndth5zne	247	5	)	)	-RRB-
cord-333722-ndth5zne	247	6	could	could	MD
cord-333722-ndth5zne	247	7	impart	impart	VB
cord-333722-ndth5zne	247	8	a	a	DT
cord-333722-ndth5zne	247	9	survival	survival	NN
cord-333722-ndth5zne	247	10	signal	signal	NN
cord-333722-ndth5zne	247	11	to	to	IN
cord-333722-ndth5zne	247	12	T	t	NN
cord-333722-ndth5zne	247	13	cells	cell	NNS
cord-333722-ndth5zne	247	14	by	by	IN
cord-333722-ndth5zne	247	15	upregulating	upregulate	VBG
cord-333722-ndth5zne	247	16	anti	anti	JJ
cord-333722-ndth5zne	247	17	-	-	JJ
cord-333722-ndth5zne	247	18	apoptosis	apoptosis	JJ
cord-333722-ndth5zne	247	19	gene	gene	NN
cord-333722-ndth5zne	247	20	expression	expression	NN
cord-333722-ndth5zne	247	21	,	,	,
cord-333722-ndth5zne	247	22	which	which	WDT
cord-333722-ndth5zne	247	23	plays	play	VBZ
cord-333722-ndth5zne	247	24	a	a	DT
cord-333722-ndth5zne	247	25	critical	critical	JJ
cord-333722-ndth5zne	247	26	role	role	NN
cord-333722-ndth5zne	247	27	in	in	IN
cord-333722-ndth5zne	247	28	T	t	NN
cord-333722-ndth5zne	247	29	-	-	HYPH
cord-333722-ndth5zne	247	30	cell	cell	NN
cord-333722-ndth5zne	247	31	-	-	HYPH
cord-333722-ndth5zne	247	32	mediated	mediate	VBN
cord-333722-ndth5zne	247	33	immunopathology	immunopathology	NN
cord-333722-ndth5zne	247	34	in	in	IN
cord-333722-ndth5zne	247	35	the	the	DT
cord-333722-ndth5zne	247	36	lung	lung	NN
cord-333722-ndth5zne	247	37	during	during	IN
cord-333722-ndth5zne	247	38	viral	viral	JJ
cord-333722-ndth5zne	247	39	infection	infection	NN
cord-333722-ndth5zne	247	40	.	.	.
cord-333722-ndth5zne	248	1	60	60	CD
cord-333722-ndth5zne	249	1	The	the	DT
cord-333722-ndth5zne	249	2	OX40-immunoglobulin	ox40-immunoglobulin	CD
cord-333722-ndth5zne	249	3	fusion	fusion	NN
cord-333722-ndth5zne	249	4	protein	protein	NN
cord-333722-ndth5zne	249	5	(	(	-LRB-
cord-333722-ndth5zne	249	6	OX40-Igs	OX40-Igs	NNP
cord-333722-ndth5zne	249	7	)	)	-RRB-
cord-333722-ndth5zne	249	8	treatment	treatment	NN
cord-333722-ndth5zne	249	9	was	be	VBD
cord-333722-ndth5zne	249	10	shown	show	VBN
cord-333722-ndth5zne	249	11	to	to	TO
cord-333722-ndth5zne	249	12	block	block	VB
cord-333722-ndth5zne	249	13	the	the	DT
cord-333722-ndth5zne	249	14	interaction	interaction	NN
cord-333722-ndth5zne	249	15	of	of	IN
cord-333722-ndth5zne	249	16	OX40	OX40	NNP
cord-333722-ndth5zne	249	17	with	with	IN
cord-333722-ndth5zne	249	18	its	-PRON-	PRP$
cord-333722-ndth5zne	249	19	ligand	ligand	NN
cord-333722-ndth5zne	249	20	on	on	IN
cord-333722-ndth5zne	249	21	antigen	antigen	NN
cord-333722-ndth5zne	249	22	-	-	HYPH
cord-333722-ndth5zne	249	23	presenting	present	VBG
cord-333722-ndth5zne	249	24	cells	cell	NNS
cord-333722-ndth5zne	249	25	and	and	CC
cord-333722-ndth5zne	249	26	eliminate	eliminate	VB
cord-333722-ndth5zne	249	27	weight	weight	NN
cord-333722-ndth5zne	249	28	loss	loss	NN
cord-333722-ndth5zne	249	29	and	and	CC
cord-333722-ndth5zne	249	30	cachexia	cachexia	NN
cord-333722-ndth5zne	249	31	without	without	IN
cord-333722-ndth5zne	249	32	preventing	prevent	VBG
cord-333722-ndth5zne	249	33	viral	viral	JJ
cord-333722-ndth5zne	249	34	clearance	clearance	NN
cord-333722-ndth5zne	249	35	in	in	IN
cord-333722-ndth5zne	249	36	influenza	influenza	NN
cord-333722-ndth5zne	249	37	-	-	HYPH
cord-333722-ndth5zne	249	38	infected	infect	VBN
cord-333722-ndth5zne	249	39	murine	murine	JJ
cord-333722-ndth5zne	249	40	models	model	NNS
cord-333722-ndth5zne	249	41	.	.	.
cord-333722-ndth5zne	250	1	60	60	CD
cord-333722-ndth5zne	251	1	It	-PRON-	PRP
cord-333722-ndth5zne	251	2	should	should	MD
cord-333722-ndth5zne	251	3	be	be	VB
cord-333722-ndth5zne	251	4	noted	note	VBN
cord-333722-ndth5zne	251	5	that	that	IN
cord-333722-ndth5zne	251	6	some	some	DT
cord-333722-ndth5zne	251	7	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	251	8	of	of	IN
cord-333722-ndth5zne	251	9	interferon	interferon	NN
cord-333722-ndth5zne	251	10	c	c	NN
cord-333722-ndth5zne	251	11	signaling	signal	VBG
cord-333722-ndth5zne	251	12	,	,	,
cord-333722-ndth5zne	251	13	such	such	JJ
cord-333722-ndth5zne	251	14	as	as	IN
cord-333722-ndth5zne	251	15	suppressors	suppressor	NNS
cord-333722-ndth5zne	251	16	of	of	IN
cord-333722-ndth5zne	251	17	cytokine	cytokine	NN
cord-333722-ndth5zne	251	18	signaling	signaling	NN
cord-333722-ndth5zne	251	19	(	(	-LRB-
cord-333722-ndth5zne	251	20	SOCSs	socs	NNS
cord-333722-ndth5zne	251	21	)	)	-RRB-
cord-333722-ndth5zne	251	22	,	,	,
cord-333722-ndth5zne	251	23	were	be	VBD
cord-333722-ndth5zne	251	24	shown	show	VBN
cord-333722-ndth5zne	251	25	to	to	TO
cord-333722-ndth5zne	251	26	have	have	VB
cord-333722-ndth5zne	251	27	negative	negative	JJ
cord-333722-ndth5zne	251	28	regulatory	regulatory	JJ
cord-333722-ndth5zne	251	29	properties	property	NNS
cord-333722-ndth5zne	251	30	and	and	CC
cord-333722-ndth5zne	251	31	participated	participate	VBD
cord-333722-ndth5zne	251	32	in	in	IN
cord-333722-ndth5zne	251	33	a	a	DT
cord-333722-ndth5zne	251	34	negative	negative	JJ
cord-333722-ndth5zne	251	35	feedback	feedback	NN
cord-333722-ndth5zne	251	36	loop	loop	NN
cord-333722-ndth5zne	251	37	in	in	IN
cord-333722-ndth5zne	251	38	the	the	DT
cord-333722-ndth5zne	251	39	JAK	JAK	NNP
cord-333722-ndth5zne	251	40	and	and	CC
cord-333722-ndth5zne	251	41	epidermal	epidermal	JJ
cord-333722-ndth5zne	251	42	growth	growth	NN
cord-333722-ndth5zne	251	43	factor	factor	NN
cord-333722-ndth5zne	251	44	receptor	receptor	NN
cord-333722-ndth5zne	251	45	tyrosine	tyrosine	NN
cord-333722-ndth5zne	251	46	kinase	kinase	NN
cord-333722-ndth5zne	251	47	pathways	pathway	NNS
cord-333722-ndth5zne	251	48	.	.	.
cord-333722-ndth5zne	252	1	61	61	CD
cord-333722-ndth5zne	253	1	These	these	DT
cord-333722-ndth5zne	253	2	proteins	protein	NNS
cord-333722-ndth5zne	253	3	are	be	VBP
cord-333722-ndth5zne	253	4	also	also	RB
cord-333722-ndth5zne	253	5	potential	potential	JJ
cord-333722-ndth5zne	253	6	agents	agent	NNS
cord-333722-ndth5zne	253	7	that	that	WDT
cord-333722-ndth5zne	253	8	protect	protect	VBP
cord-333722-ndth5zne	253	9	against	against	IN
cord-333722-ndth5zne	253	10	cytokine	cytokine	NN
cord-333722-ndth5zne	253	11	storm	storm	NN
cord-333722-ndth5zne	253	12	during	during	IN
cord-333722-ndth5zne	253	13	severe	severe	JJ
cord-333722-ndth5zne	253	14	influenza	influenza	NN
cord-333722-ndth5zne	253	15	.	.	.
cord-333722-ndth5zne	254	1	61	61	CD
cord-333722-ndth5zne	255	1	All	all	PDT
cord-333722-ndth5zne	255	2	these	these	DT
cord-333722-ndth5zne	255	3	findings	finding	NNS
cord-333722-ndth5zne	255	4	offer	offer	VBP
cord-333722-ndth5zne	255	5	a	a	DT
cord-333722-ndth5zne	255	6	great	great	JJ
cord-333722-ndth5zne	255	7	deal	deal	NN
cord-333722-ndth5zne	255	8	of	of	IN
cord-333722-ndth5zne	255	9	encouragement	encouragement	NN
cord-333722-ndth5zne	255	10	for	for	IN
cord-333722-ndth5zne	255	11	treating	treat	VBG
cord-333722-ndth5zne	255	12	influenza	influenza	NN
cord-333722-ndth5zne	255	13	-	-	HYPH
cord-333722-ndth5zne	255	14	induced	induce	VBN
cord-333722-ndth5zne	255	15	cytokine	cytokine	NN
cord-333722-ndth5zne	255	16	storm	storm	NN
cord-333722-ndth5zne	255	17	with	with	IN
cord-333722-ndth5zne	255	18	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	255	19	agents	agent	NNS
cord-333722-ndth5zne	255	20	.	.	.
cord-333722-ndth5zne	256	1	Some	some	DT
cord-333722-ndth5zne	256	2	antibiotics	antibiotic	NNS
cord-333722-ndth5zne	256	3	and	and	CC
cord-333722-ndth5zne	256	4	antivirals	antiviral	NNS
cord-333722-ndth5zne	256	5	are	be	VBP
cord-333722-ndth5zne	256	6	also	also	RB
cord-333722-ndth5zne	256	7	known	know	VBN
cord-333722-ndth5zne	256	8	to	to	TO
cord-333722-ndth5zne	256	9	possess	possess	VB
cord-333722-ndth5zne	256	10	anti	anti	JJ
cord-333722-ndth5zne	256	11	-	-	JJ
cord-333722-ndth5zne	256	12	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	256	13	effects	effect	NNS
cord-333722-ndth5zne	256	14	and	and	CC
cord-333722-ndth5zne	256	15	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	256	16	properties	property	NNS
cord-333722-ndth5zne	256	17	in	in	IN
cord-333722-ndth5zne	256	18	addition	addition	NN
cord-333722-ndth5zne	256	19	to	to	IN
cord-333722-ndth5zne	256	20	their	-PRON-	PRP$
cord-333722-ndth5zne	256	21	anti	anti	JJ
cord-333722-ndth5zne	256	22	-	-	JJ
cord-333722-ndth5zne	256	23	pathogenic	pathogenic	JJ
cord-333722-ndth5zne	256	24	actions	action	NNS
cord-333722-ndth5zne	256	25	.	.	.
cord-333722-ndth5zne	257	1	Both	both	DT
cord-333722-ndth5zne	257	2	in	in	IN
cord-333722-ndth5zne	257	3	vitro	vitro	FW
cord-333722-ndth5zne	257	4	and	and	CC
cord-333722-ndth5zne	257	5	in	in	IN
cord-333722-ndth5zne	257	6	vivo	vivo	NNP
cord-333722-ndth5zne	257	7	studies	study	NNS
cord-333722-ndth5zne	257	8	have	have	VBP
cord-333722-ndth5zne	257	9	provided	provide	VBN
cord-333722-ndth5zne	257	10	ample	ample	JJ
cord-333722-ndth5zne	257	11	evidence	evidence	NN
cord-333722-ndth5zne	257	12	for	for	IN
cord-333722-ndth5zne	257	13	the	the	DT
cord-333722-ndth5zne	257	14	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	257	15	and	and	CC
cord-333722-ndth5zne	257	16	anti	anti	JJ
cord-333722-ndth5zne	257	17	-	-	JJ
cord-333722-ndth5zne	257	18	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	257	19	activity	activity	NN
cord-333722-ndth5zne	257	20	of	of	IN
cord-333722-ndth5zne	257	21	macrolides	macrolide	NNS
cord-333722-ndth5zne	257	22	(	(	-LRB-
cord-333722-ndth5zne	257	23	e.g.	e.g.	RB
cord-333722-ndth5zne	257	24	,	,	,
cord-333722-ndth5zne	257	25	erythromycin	erythromycin	NN
cord-333722-ndth5zne	257	26	,	,	,
cord-333722-ndth5zne	257	27	clarithromycin	clarithromycin	NNP
cord-333722-ndth5zne	257	28	,	,	,
cord-333722-ndth5zne	257	29	roxithromycin	roxithromycin	NNS
cord-333722-ndth5zne	257	30	,	,	,
cord-333722-ndth5zne	257	31	and	and	CC
cord-333722-ndth5zne	257	32	azithromycin	azithromycin	NN
cord-333722-ndth5zne	257	33	)	)	-RRB-
cord-333722-ndth5zne	257	34	.	.	.
cord-333722-ndth5zne	258	1	62	62	CD
cord-333722-ndth5zne	259	1	Macrolides	macrolide	NNS
cord-333722-ndth5zne	259	2	can	can	MD
cord-333722-ndth5zne	259	3	interfere	interfere	VB
cord-333722-ndth5zne	259	4	with	with	IN
cord-333722-ndth5zne	259	5	the	the	DT
cord-333722-ndth5zne	259	6	replication	replication	NN
cord-333722-ndth5zne	259	7	cycle	cycle	NN
cord-333722-ndth5zne	259	8	of	of	IN
cord-333722-ndth5zne	259	9	influenza	influenza	NN
cord-333722-ndth5zne	259	10	virus	virus	NN
cord-333722-ndth5zne	259	11	,	,	,
cord-333722-ndth5zne	259	12	resulting	result	VBG
cord-333722-ndth5zne	259	13	in	in	IN
cord-333722-ndth5zne	259	14	the	the	DT
cord-333722-ndth5zne	259	15	inhibition	inhibition	NN
cord-333722-ndth5zne	259	16	of	of	IN
cord-333722-ndth5zne	259	17	viral	viral	JJ
cord-333722-ndth5zne	259	18	production	production	NN
cord-333722-ndth5zne	259	19	from	from	IN
cord-333722-ndth5zne	259	20	infected	infected	JJ
cord-333722-ndth5zne	259	21	cells	cell	NNS
cord-333722-ndth5zne	259	22	.	.	.
cord-333722-ndth5zne	260	1	Moreover	moreover	RB
cord-333722-ndth5zne	260	2	,	,	,
cord-333722-ndth5zne	260	3	macrolide	macrolide	JJ
cord-333722-ndth5zne	260	4	treatment	treatment	NN
cord-333722-ndth5zne	260	5	of	of	IN
cord-333722-ndth5zne	260	6	influenza	influenza	NN
cord-333722-ndth5zne	260	7	virus	virus	NN
cord-333722-ndth5zne	260	8	-	-	HYPH
cord-333722-ndth5zne	260	9	infected	infect	VBN
cord-333722-ndth5zne	260	10	mice	mouse	NNS
cord-333722-ndth5zne	260	11	increased	increase	VBD
cord-333722-ndth5zne	260	12	survival	survival	NN
cord-333722-ndth5zne	260	13	,	,	,
cord-333722-ndth5zne	260	14	suppressed	suppress	VBN
cord-333722-ndth5zne	260	15	inflammation	inflammation	NN
cord-333722-ndth5zne	260	16	,	,	,
cord-333722-ndth5zne	260	17	and	and	CC
cord-333722-ndth5zne	260	18	reduced	reduce	VBN
cord-333722-ndth5zne	260	19	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	260	20	cell	cell	NN
cord-333722-ndth5zne	260	21	counts	count	NNS
cord-333722-ndth5zne	260	22	.	.	.
cord-333722-ndth5zne	261	1	62	62	CD
cord-333722-ndth5zne	262	1	Arbidol	Arbidol	NNP
cord-333722-ndth5zne	262	2	is	be	VBZ
cord-333722-ndth5zne	262	3	an	an	DT
cord-333722-ndth5zne	262	4	antiviral	antiviral	JJ
cord-333722-ndth5zne	262	5	that	that	WDT
cord-333722-ndth5zne	262	6	has	have	VBZ
cord-333722-ndth5zne	262	7	complicated	complicate	VBN
cord-333722-ndth5zne	262	8	mechanisms	mechanism	NNS
cord-333722-ndth5zne	262	9	.	.	.
cord-333722-ndth5zne	263	1	Both	both	DT
cord-333722-ndth5zne	263	2	membranefusion	membranefusion	NN
cord-333722-ndth5zne	263	3	-	-	HYPH
cord-333722-ndth5zne	263	4	inhibition	inhibition	NN
cord-333722-ndth5zne	263	5	and	and	CC
cord-333722-ndth5zne	263	6	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	263	7	activity	activity	NN
cord-333722-ndth5zne	263	8	may	may	MD
cord-333722-ndth5zne	263	9	contribute	contribute	VB
cord-333722-ndth5zne	263	10	to	to	IN
cord-333722-ndth5zne	263	11	its	-PRON-	PRP$
cord-333722-ndth5zne	263	12	effects	effect	NNS
cord-333722-ndth5zne	263	13	.	.	.
cord-333722-ndth5zne	264	1	63	63	CD
cord-333722-ndth5zne	265	1	Our	-PRON-	PRP$
cord-333722-ndth5zne	265	2	current	current	JJ
cord-333722-ndth5zne	265	3	research	research	NN
cord-333722-ndth5zne	265	4	confirmed	confirm	VBD
cord-333722-ndth5zne	265	5	that	that	IN
cord-333722-ndth5zne	265	6	post	post	JJ
cord-333722-ndth5zne	265	7	-	-	NN
cord-333722-ndth5zne	265	8	treatment	treatment	JJ
cord-333722-ndth5zne	265	9	with	with	IN
cord-333722-ndth5zne	265	10	arbidol	arbidol	NN
cord-333722-ndth5zne	265	11	-	-	HYPH
cord-333722-ndth5zne	265	12	reduced	reduce	VBN
cord-333722-ndth5zne	265	13	mortality	mortality	NN
cord-333722-ndth5zne	265	14	,	,	,
cord-333722-ndth5zne	265	15	lung	lung	NN
cord-333722-ndth5zne	265	16	lesion	lesion	NN
cord-333722-ndth5zne	265	17	formation	formation	NN
cord-333722-ndth5zne	265	18	,	,	,
cord-333722-ndth5zne	265	19	and	and	CC
cord-333722-ndth5zne	265	20	viral	viral	RB
cord-333722-ndth5zne	265	21	-	-	HYPH
cord-333722-ndth5zne	265	22	induced	induce	VBN
cord-333722-ndth5zne	265	23	inflammation	inflammation	NN
cord-333722-ndth5zne	265	24	by	by	IN
cord-333722-ndth5zne	265	25	modulating	modulate	VBG
cord-333722-ndth5zne	265	26	the	the	DT
cord-333722-ndth5zne	265	27	expression	expression	NN
cord-333722-ndth5zne	265	28	of	of	IN
cord-333722-ndth5zne	265	29	pro	pro	JJ
cord-333722-ndth5zne	265	30	-	-	JJ
cord-333722-ndth5zne	265	31	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	265	32	cytokines	cytokine	NNS
cord-333722-ndth5zne	265	33	in	in	IN
cord-333722-ndth5zne	265	34	influenzainfected	influenzainfected	JJ
cord-333722-ndth5zne	265	35	mice	mouse	NNS
cord-333722-ndth5zne	265	36	.	.	.
cord-333722-ndth5zne	266	1	64	64	CD
cord-333722-ndth5zne	267	1	These	these	DT
cord-333722-ndth5zne	267	2	data	datum	NNS
cord-333722-ndth5zne	267	3	suggest	suggest	VBP
cord-333722-ndth5zne	267	4	that	that	IN
cord-333722-ndth5zne	267	5	arbidol	arbidol	NN
cord-333722-ndth5zne	267	6	might	may	MD
cord-333722-ndth5zne	267	7	also	also	RB
cord-333722-ndth5zne	267	8	be	be	VB
cord-333722-ndth5zne	267	9	effective	effective	JJ
cord-333722-ndth5zne	267	10	in	in	IN
cord-333722-ndth5zne	267	11	the	the	DT
cord-333722-ndth5zne	267	12	treatment	treatment	NN
cord-333722-ndth5zne	267	13	of	of	IN
cord-333722-ndth5zne	267	14	severe	severe	JJ
cord-333722-ndth5zne	267	15	influenza	influenza	NN
cord-333722-ndth5zne	267	16	infections	infection	NNS
cord-333722-ndth5zne	267	17	in	in	IN
cord-333722-ndth5zne	267	18	humans	human	NNS
cord-333722-ndth5zne	267	19	.	.	.
cord-333722-ndth5zne	268	1	Herbs	herb	NNS
cord-333722-ndth5zne	268	2	may	may	MD
cord-333722-ndth5zne	268	3	also	also	RB
cord-333722-ndth5zne	268	4	be	be	VB
cord-333722-ndth5zne	268	5	a	a	DT
cord-333722-ndth5zne	268	6	potential	potential	JJ
cord-333722-ndth5zne	268	7	choice	choice	NN
cord-333722-ndth5zne	268	8	for	for	IN
cord-333722-ndth5zne	268	9	patients	patient	NNS
cord-333722-ndth5zne	268	10	hospitalized	hospitalize	VBN
cord-333722-ndth5zne	268	11	with	with	IN
cord-333722-ndth5zne	268	12	severe	severe	JJ
cord-333722-ndth5zne	268	13	influenza	influenza	NN
cord-333722-ndth5zne	268	14	.	.	.
cord-333722-ndth5zne	269	1	Several	several	JJ
cord-333722-ndth5zne	269	2	Chinese	chinese	JJ
cord-333722-ndth5zne	269	3	herbal	herbal	JJ
cord-333722-ndth5zne	269	4	prescriptions	prescription	NNS
cord-333722-ndth5zne	269	5	were	be	VBD
cord-333722-ndth5zne	269	6	recommended	recommend	VBN
cord-333722-ndth5zne	269	7	and	and	CC
cord-333722-ndth5zne	269	8	authorized	authorize	VBN
cord-333722-ndth5zne	269	9	by	by	IN
cord-333722-ndth5zne	269	10	the	the	DT
cord-333722-ndth5zne	269	11	Chinese	chinese	JJ
cord-333722-ndth5zne	269	12	government	government	NN
cord-333722-ndth5zne	269	13	during	during	IN
cord-333722-ndth5zne	269	14	the	the	DT
cord-333722-ndth5zne	269	15	2009	2009	CD
cord-333722-ndth5zne	269	16	H1N1	H1N1	NNP
cord-333722-ndth5zne	269	17	and	and	CC
cord-333722-ndth5zne	269	18	2013	2013	CD
cord-333722-ndth5zne	269	19	H7N9	H7N9	NNP
cord-333722-ndth5zne	269	20	pandemics	pandemic	NNS
cord-333722-ndth5zne	269	21	.	.	.
cord-333722-ndth5zne	270	1	65	65	CD
cord-333722-ndth5zne	271	1	,	,	,
cord-333722-ndth5zne	271	2	66	66	CD
cord-333722-ndth5zne	271	3	Systematic	systematic	JJ
cord-333722-ndth5zne	271	4	reviews	review	NNS
cord-333722-ndth5zne	271	5	for	for	IN
cord-333722-ndth5zne	271	6	clinical	clinical	JJ
cord-333722-ndth5zne	271	7	trials	trial	NNS
cord-333722-ndth5zne	271	8	of	of	IN
cord-333722-ndth5zne	271	9	these	these	DT
cord-333722-ndth5zne	271	10	herbs	herb	NNS
cord-333722-ndth5zne	271	11	used	use	VBN
cord-333722-ndth5zne	271	12	in	in	IN
cord-333722-ndth5zne	271	13	influenza	influenza	NN
cord-333722-ndth5zne	271	14	treatment	treatment	NN
cord-333722-ndth5zne	271	15	have	have	VBP
cord-333722-ndth5zne	271	16	revealed	reveal	VBN
cord-333722-ndth5zne	271	17	that	that	IN
cord-333722-ndth5zne	271	18	few	few	JJ
cord-333722-ndth5zne	271	19	herbal	herbal	JJ
cord-333722-ndth5zne	271	20	medicines	medicine	NNS
cord-333722-ndth5zne	271	21	showed	show	VBD
cord-333722-ndth5zne	271	22	a	a	DT
cord-333722-ndth5zne	271	23	positive	positive	JJ
cord-333722-ndth5zne	271	24	effect	effect	NN
cord-333722-ndth5zne	271	25	on	on	IN
cord-333722-ndth5zne	271	26	viral	viral	JJ
cord-333722-ndth5zne	271	27	shedding	shedding	NN
cord-333722-ndth5zne	271	28	,	,	,
cord-333722-ndth5zne	271	29	but	but	CC
cord-333722-ndth5zne	271	30	they	-PRON-	PRP
cord-333722-ndth5zne	271	31	had	have	VBD
cord-333722-ndth5zne	271	32	a	a	DT
cord-333722-ndth5zne	271	33	positive	positive	JJ
cord-333722-ndth5zne	271	34	effect	effect	NN
cord-333722-ndth5zne	271	35	on	on	IN
cord-333722-ndth5zne	271	36	resolution	resolution	NN
cord-333722-ndth5zne	271	37	or	or	CC
cord-333722-ndth5zne	271	38	relief	relief	NN
cord-333722-ndth5zne	271	39	of	of	IN
cord-333722-ndth5zne	271	40	symptoms	symptom	NNS
cord-333722-ndth5zne	271	41	.	.	.
cord-333722-ndth5zne	272	1	67	67	CD
cord-333722-ndth5zne	272	2	,	,	,
cord-333722-ndth5zne	272	3	68	68	CD
cord-333722-ndth5zne	273	1	Moreover	moreover	RB
cord-333722-ndth5zne	273	2	,	,	,
cord-333722-ndth5zne	273	3	many	many	JJ
cord-333722-ndth5zne	273	4	herbs	herb	NNS
cord-333722-ndth5zne	273	5	exhibit	exhibit	VBP
cord-333722-ndth5zne	273	6	beneficial	beneficial	JJ
cord-333722-ndth5zne	273	7	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	273	8	effects	effect	NNS
cord-333722-ndth5zne	273	9	for	for	IN
cord-333722-ndth5zne	273	10	the	the	DT
cord-333722-ndth5zne	273	11	rapid	rapid	JJ
cord-333722-ndth5zne	273	12	recovery	recovery	NN
cord-333722-ndth5zne	273	13	of	of	IN
cord-333722-ndth5zne	273	14	viral	viral	JJ
cord-333722-ndth5zne	273	15	infections	infection	NNS
cord-333722-ndth5zne	273	16	and	and	CC
cord-333722-ndth5zne	273	17	might	may	MD
cord-333722-ndth5zne	273	18	be	be	VB
cord-333722-ndth5zne	273	19	effective	effective	JJ
cord-333722-ndth5zne	273	20	treatments	treatment	NNS
cord-333722-ndth5zne	273	21	for	for	IN
cord-333722-ndth5zne	273	22	infection	infection	NN
cord-333722-ndth5zne	273	23	with	with	IN
cord-333722-ndth5zne	273	24	severe	severe	JJ
cord-333722-ndth5zne	273	25	influenza	influenza	NN
cord-333722-ndth5zne	273	26	.	.	.
cord-333722-ndth5zne	274	1	69	69	CD
cord-333722-ndth5zne	275	1	We	-PRON-	PRP
cord-333722-ndth5zne	275	2	have	have	VBP
cord-333722-ndth5zne	275	3	reported	report	VBN
cord-333722-ndth5zne	275	4	that	that	IN
cord-333722-ndth5zne	275	5	extracts	extract	NNS
cord-333722-ndth5zne	275	6	from	from	IN
cord-333722-ndth5zne	275	7	Jiawei	Jiawei	NNP
cord-333722-ndth5zne	275	8	-	-	HYPH
cord-333722-ndth5zne	275	9	Yupingfeng	Yupingfeng	NNP
cord-333722-ndth5zne	275	10	-	-	HYPH
cord-333722-ndth5zne	275	11	Tang	Tang	NNP
cord-333722-ndth5zne	275	12	(	(	-LRB-
cord-333722-ndth5zne	275	13	a	a	DT
cord-333722-ndth5zne	275	14	traditional	traditional	JJ
cord-333722-ndth5zne	275	15	Chinese	chinese	JJ
cord-333722-ndth5zne	275	16	herbal	herbal	JJ
cord-333722-ndth5zne	275	17	formula	formula	NN
cord-333722-ndth5zne	275	18	)	)	-RRB-
cord-333722-ndth5zne	275	19	can	can	MD
cord-333722-ndth5zne	275	20	alleviate	alleviate	VB
cord-333722-ndth5zne	275	21	influenzainduced	influenzainduce	VBN
cord-333722-ndth5zne	275	22	lung	lung	NN
cord-333722-ndth5zne	275	23	lesions	lesion	NNS
cord-333722-ndth5zne	275	24	with	with	IN
cord-333722-ndth5zne	275	25	both	both	DT
cord-333722-ndth5zne	275	26	antiviral	antiviral	JJ
cord-333722-ndth5zne	275	27	and	and	CC
cord-333722-ndth5zne	275	28	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	275	29	activity	activity	NN
cord-333722-ndth5zne	275	30	.	.	.
cord-333722-ndth5zne	276	1	70	70	CD
cord-333722-ndth5zne	277	1	We	-PRON-	PRP
cord-333722-ndth5zne	277	2	also	also	RB
cord-333722-ndth5zne	277	3	have	have	VBP
cord-333722-ndth5zne	277	4	confirmed	confirm	VBN
cord-333722-ndth5zne	277	5	that	that	IN
cord-333722-ndth5zne	277	6	epigallocatechin	epigallocatechin	NNP
cord-333722-ndth5zne	277	7	gallate	gallate	NNP
cord-333722-ndth5zne	277	8	(	(	-LRB-
cord-333722-ndth5zne	277	9	EGCG	EGCG	NNP
cord-333722-ndth5zne	277	10	)	)	-RRB-
cord-333722-ndth5zne	277	11	,	,	,
cord-333722-ndth5zne	277	12	a	a	DT
cord-333722-ndth5zne	277	13	green	green	JJ
cord-333722-ndth5zne	277	14	tea	tea	NN
cord-333722-ndth5zne	277	15	-	-	HYPH
cord-333722-ndth5zne	277	16	derived	derive	VBN
cord-333722-ndth5zne	277	17	polyphenol	polyphenol	NN
cord-333722-ndth5zne	277	18	,	,	,
cord-333722-ndth5zne	277	19	can	can	MD
cord-333722-ndth5zne	277	20	inhibit	inhibit	VB
cord-333722-ndth5zne	277	21	the	the	DT
cord-333722-ndth5zne	277	22	pathogenesis	pathogenesis	NN
cord-333722-ndth5zne	277	23	of	of	IN
cord-333722-ndth5zne	277	24	influenza	influenza	NN
cord-333722-ndth5zne	277	25	-	-	HYPH
cord-333722-ndth5zne	277	26	infected	infect	VBN
cord-333722-ndth5zne	277	27	cells	cell	NNS
cord-333722-ndth5zne	277	28	due	due	IN
cord-333722-ndth5zne	277	29	to	to	IN
cord-333722-ndth5zne	277	30	its	-PRON-	PRP$
cord-333722-ndth5zne	277	31	antioxidant	antioxidant	JJ
cord-333722-ndth5zne	277	32	activity	activity	NN
cord-333722-ndth5zne	277	33	.	.	.
cord-333722-ndth5zne	278	1	71	71	CD
cord-333722-ndth5zne	278	2	Polyphenols	Polyphenols	NNPS
cord-333722-ndth5zne	278	3	,	,	,
cord-333722-ndth5zne	278	4	triterpenoids	triterpenoid	NNS
cord-333722-ndth5zne	278	5	,	,	,
cord-333722-ndth5zne	278	6	and	and	CC
cord-333722-ndth5zne	278	7	flavonoids	flavonoid	NNS
cord-333722-ndth5zne	278	8	,	,	,
cord-333722-ndth5zne	278	9	all	all	DT
cord-333722-ndth5zne	278	10	from	from	IN
cord-333722-ndth5zne	278	11	herbs	herb	NNS
cord-333722-ndth5zne	278	12	,	,	,
cord-333722-ndth5zne	278	13	may	may	MD
cord-333722-ndth5zne	278	14	potentially	potentially	RB
cord-333722-ndth5zne	278	15	be	be	VB
cord-333722-ndth5zne	278	16	active	active	JJ
cord-333722-ndth5zne	278	17	components	component	NNS
cord-333722-ndth5zne	278	18	in	in	IN
cord-333722-ndth5zne	278	19	protecting	protect	VBG
cord-333722-ndth5zne	278	20	against	against	IN
cord-333722-ndth5zne	278	21	cytokine	cytokine	NN
cord-333722-ndth5zne	278	22	storm	storm	NN
cord-333722-ndth5zne	278	23	during	during	IN
cord-333722-ndth5zne	278	24	severe	severe	JJ
cord-333722-ndth5zne	278	25	influenza	influenza	NN
cord-333722-ndth5zne	278	26	(	(	-LRB-
cord-333722-ndth5zne	278	27	unpublished	unpublished	JJ
cord-333722-ndth5zne	278	28	data	datum	NNS
cord-333722-ndth5zne	278	29	)	)	-RRB-
cord-333722-ndth5zne	278	30	.	.	.
cord-333722-ndth5zne	279	1	However	however	RB
cord-333722-ndth5zne	279	2	,	,	,
cord-333722-ndth5zne	279	3	confirmation	confirmation	NN
cord-333722-ndth5zne	279	4	in	in	IN
cord-333722-ndth5zne	279	5	a	a	DT
cord-333722-ndth5zne	279	6	larger	large	JJR
cord-333722-ndth5zne	279	7	series	series	NN
cord-333722-ndth5zne	279	8	of	of	IN
cord-333722-ndth5zne	279	9	clinical	clinical	JJ
cord-333722-ndth5zne	279	10	studies	study	NNS
cord-333722-ndth5zne	279	11	is	be	VBZ
cord-333722-ndth5zne	279	12	required	require	VBN
cord-333722-ndth5zne	279	13	.	.	.
cord-333722-ndth5zne	280	1	The	the	DT
cord-333722-ndth5zne	280	2	persistent	persistent	JJ
cord-333722-ndth5zne	280	3	outbreaks	outbreak	NNS
cord-333722-ndth5zne	280	4	of	of	IN
cord-333722-ndth5zne	280	5	avian	avian	JJ
cord-333722-ndth5zne	280	6	influenza	influenza	NN
cord-333722-ndth5zne	280	7	in	in	IN
cord-333722-ndth5zne	280	8	Asia	Asia	NNP
cord-333722-ndth5zne	280	9	and	and	CC
cord-333722-ndth5zne	280	10	parts	part	NNS
cord-333722-ndth5zne	280	11	of	of	IN
cord-333722-ndth5zne	280	12	Africa	Africa	NNP
cord-333722-ndth5zne	280	13	suggest	suggest	VBP
cord-333722-ndth5zne	280	14	that	that	IN
cord-333722-ndth5zne	280	15	severe	severe	JJ
cord-333722-ndth5zne	280	16	influenza	influenza	NN
cord-333722-ndth5zne	280	17	,	,	,
cord-333722-ndth5zne	280	18	such	such	JJ
cord-333722-ndth5zne	280	19	as	as	IN
cord-333722-ndth5zne	280	20	avian	avian	JJ
cord-333722-ndth5zne	280	21	influenza	influenza	NN
cord-333722-ndth5zne	280	22	,	,	,
cord-333722-ndth5zne	280	23	poses	pose	VBZ
cord-333722-ndth5zne	280	24	a	a	DT
cord-333722-ndth5zne	280	25	major	major	JJ
cord-333722-ndth5zne	280	26	threat	threat	NN
cord-333722-ndth5zne	280	27	to	to	IN
cord-333722-ndth5zne	280	28	public	public	JJ
cord-333722-ndth5zne	280	29	health	health	NN
cord-333722-ndth5zne	280	30	.	.	.
cord-333722-ndth5zne	281	1	Many	many	JJ
cord-333722-ndth5zne	281	2	severe	severe	JJ
cord-333722-ndth5zne	281	3	-	-	HYPH
cord-333722-ndth5zne	281	4	influenzainfected	influenzainfecte	VBN
cord-333722-ndth5zne	281	5	patients	patient	NNS
cord-333722-ndth5zne	281	6	died	die	VBD
cord-333722-ndth5zne	281	7	from	from	IN
cord-333722-ndth5zne	281	8	overwhelming	overwhelming	JJ
cord-333722-ndth5zne	281	9	viral	viral	JJ
cord-333722-ndth5zne	281	10	pneumonia	pneumonia	NN
cord-333722-ndth5zne	281	11	and	and	CC
cord-333722-ndth5zne	281	12	serious	serious	JJ
cord-333722-ndth5zne	281	13	complications	complication	NNS
cord-333722-ndth5zne	281	14	caused	cause	VBN
cord-333722-ndth5zne	281	15	by	by	IN
cord-333722-ndth5zne	281	16	cytokine	cytokine	NN
cord-333722-ndth5zne	281	17	storm	storm	NN
cord-333722-ndth5zne	281	18	.	.	.
cord-333722-ndth5zne	282	1	In	in	IN
cord-333722-ndth5zne	282	2	this	this	DT
cord-333722-ndth5zne	282	3	review	review	NN
cord-333722-ndth5zne	282	4	,	,	,
cord-333722-ndth5zne	282	5	we	-PRON-	PRP
cord-333722-ndth5zne	282	6	have	have	VBP
cord-333722-ndth5zne	282	7	highlighted	highlight	VBN
cord-333722-ndth5zne	282	8	the	the	DT
cord-333722-ndth5zne	282	9	pathology	pathology	NN
cord-333722-ndth5zne	282	10	of	of	IN
cord-333722-ndth5zne	282	11	cytokine	cytokine	NN
cord-333722-ndth5zne	282	12	storm	storm	NN
cord-333722-ndth5zne	282	13	and	and	CC
cord-333722-ndth5zne	282	14	,	,	,
cord-333722-ndth5zne	282	15	in	in	IN
cord-333722-ndth5zne	282	16	particular	particular	JJ
cord-333722-ndth5zne	282	17	,	,	,
cord-333722-ndth5zne	282	18	how	how	WRB
cord-333722-ndth5zne	282	19	an	an	DT
cord-333722-ndth5zne	282	20	enhanced	enhanced	JJ
cord-333722-ndth5zne	282	21	broad	broad	JJ
cord-333722-ndth5zne	282	22	immune	immune	JJ
cord-333722-ndth5zne	282	23	response	response	NN
cord-333722-ndth5zne	282	24	can	can	MD
cord-333722-ndth5zne	282	25	sometimes	sometimes	RB
cord-333722-ndth5zne	282	26	worsen	worsen	VB
cord-333722-ndth5zne	282	27	the	the	DT
cord-333722-ndth5zne	282	28	outcome	outcome	NN
cord-333722-ndth5zne	282	29	of	of	IN
cord-333722-ndth5zne	282	30	disease	disease	NN
cord-333722-ndth5zne	282	31	.	.	.
cord-333722-ndth5zne	283	1	Although	although	IN
cord-333722-ndth5zne	283	2	the	the	DT
cord-333722-ndth5zne	283	3	precise	precise	JJ
cord-333722-ndth5zne	283	4	molecular	molecular	JJ
cord-333722-ndth5zne	283	5	events	event	NNS
cord-333722-ndth5zne	283	6	surrounding	surround	VBG
cord-333722-ndth5zne	283	7	cytokine	cytokine	NN
cord-333722-ndth5zne	283	8	storm	storm	NN
cord-333722-ndth5zne	283	9	have	have	VBP
cord-333722-ndth5zne	283	10	not	not	RB
cord-333722-ndth5zne	283	11	been	be	VBN
cord-333722-ndth5zne	283	12	clarified	clarify	VBN
cord-333722-ndth5zne	283	13	,	,	,
cord-333722-ndth5zne	283	14	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	283	15	strategies	strategy	NNS
cord-333722-ndth5zne	283	16	and	and	CC
cord-333722-ndth5zne	283	17	novel	novel	NN
cord-333722-ndth5zne	283	18	approaches	approach	NNS
cord-333722-ndth5zne	283	19	in	in	IN
cord-333722-ndth5zne	283	20	targeting	target	VBG
cord-333722-ndth5zne	283	21	the	the	DT
cord-333722-ndth5zne	283	22	host	host	NN
cord-333722-ndth5zne	283	23	's	's	POS
cord-333722-ndth5zne	283	24	response	response	NN
cord-333722-ndth5zne	283	25	to	to	IN
cord-333722-ndth5zne	283	26	severe	severe	JJ
cord-333722-ndth5zne	283	27	influenza	influenza	NN
cord-333722-ndth5zne	283	28	have	have	VBP
cord-333722-ndth5zne	283	29	been	be	VBN
cord-333722-ndth5zne	283	30	advocated	advocate	VBN
cord-333722-ndth5zne	283	31	.	.	.
cord-333722-ndth5zne	284	1	Considering	consider	VBG
cord-333722-ndth5zne	284	2	that	that	IN
cord-333722-ndth5zne	284	3	these	these	DT
cord-333722-ndth5zne	284	4	agents	agent	NNS
cord-333722-ndth5zne	284	5	work	work	VBP
cord-333722-ndth5zne	284	6	on	on	IN
cord-333722-ndth5zne	284	7	different	different	JJ
cord-333722-ndth5zne	284	8	intracellular	intracellular	JJ
cord-333722-ndth5zne	284	9	pathways	pathway	NNS
cord-333722-ndth5zne	284	10	,	,	,
cord-333722-ndth5zne	284	11	they	-PRON-	PRP
cord-333722-ndth5zne	284	12	might	may	MD
cord-333722-ndth5zne	284	13	ideally	ideally	RB
cord-333722-ndth5zne	284	14	be	be	VB
cord-333722-ndth5zne	284	15	used	use	VBN
cord-333722-ndth5zne	284	16	in	in	IN
cord-333722-ndth5zne	284	17	combination	combination	NN
cord-333722-ndth5zne	284	18	to	to	TO
cord-333722-ndth5zne	284	19	obtain	obtain	VB
cord-333722-ndth5zne	284	20	a	a	DT
cord-333722-ndth5zne	284	21	better	well	JJR
cord-333722-ndth5zne	284	22	outcome	outcome	NN
cord-333722-ndth5zne	284	23	.	.	.
cord-333722-ndth5zne	285	1	Based	base	VBN
cord-333722-ndth5zne	285	2	on	on	IN
cord-333722-ndth5zne	285	3	the	the	DT
cord-333722-ndth5zne	285	4	promising	promising	JJ
cord-333722-ndth5zne	285	5	results	result	NNS
cord-333722-ndth5zne	285	6	mentioned	mention	VBN
cord-333722-ndth5zne	285	7	above	above	RB
cord-333722-ndth5zne	285	8	,	,	,
cord-333722-ndth5zne	285	9	combination	combination	NN
cord-333722-ndth5zne	285	10	therapies	therapy	NNS
cord-333722-ndth5zne	285	11	pairing	pair	VBG
cord-333722-ndth5zne	285	12	S1PR	S1PR	NNP
cord-333722-ndth5zne	285	13	and	and	CC
cord-333722-ndth5zne	285	14	PPAR	PPAR	NNP
cord-333722-ndth5zne	285	15	agonists	agonist	NNS
cord-333722-ndth5zne	285	16	,	,	,
cord-333722-ndth5zne	285	17	COX-2	COX-2	NNP
cord-333722-ndth5zne	285	18	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	285	19	,	,	,
cord-333722-ndth5zne	285	20	and	and	CC
cord-333722-ndth5zne	285	21	antioxidants	antioxidant	NNS
cord-333722-ndth5zne	285	22	with	with	IN
cord-333722-ndth5zne	285	23	conventional	conventional	JJ
cord-333722-ndth5zne	285	24	antiviral	antiviral	JJ
cord-333722-ndth5zne	285	25	agents	agent	NNS
cord-333722-ndth5zne	285	26	are	be	VBP
cord-333722-ndth5zne	285	27	promising	promising	JJ
cord-333722-ndth5zne	285	28	treatments	treatment	NNS
cord-333722-ndth5zne	285	29	that	that	WDT
cord-333722-ndth5zne	285	30	deserve	deserve	VBP
cord-333722-ndth5zne	285	31	further	further	JJ
cord-333722-ndth5zne	285	32	study	study	NN
cord-333722-ndth5zne	285	33	in	in	IN
cord-333722-ndth5zne	285	34	randomized	randomized	JJ
cord-333722-ndth5zne	285	35	clinical	clinical	JJ
cord-333722-ndth5zne	285	36	trials	trial	NNS
cord-333722-ndth5zne	285	37	.	.	.
cord-333722-ndth5zne	286	1	Other	other	JJ
cord-333722-ndth5zne	286	2	approaches	approach	NNS
cord-333722-ndth5zne	286	3	,	,	,
cord-333722-ndth5zne	286	4	especially	especially	RB
cord-333722-ndth5zne	286	5	those	those	DT
cord-333722-ndth5zne	286	6	therapeutic	therapeutic	JJ
cord-333722-ndth5zne	286	7	strategies	strategy	NNS
cord-333722-ndth5zne	286	8	that	that	WDT
cord-333722-ndth5zne	286	9	can	can	MD
cord-333722-ndth5zne	286	10	target	target	VB
cord-333722-ndth5zne	286	11	signaling	signal	VBG
cord-333722-ndth5zne	286	12	pathways	pathway	NNS
cord-333722-ndth5zne	286	13	,	,	,
cord-333722-ndth5zne	286	14	either	either	CC
cord-333722-ndth5zne	286	15	to	to	TO
cord-333722-ndth5zne	286	16	suppress	suppress	VB
cord-333722-ndth5zne	286	17	redundant	redundant	JJ
cord-333722-ndth5zne	286	18	immune	immune	JJ
cord-333722-ndth5zne	286	19	responses	response	NNS
cord-333722-ndth5zne	286	20	or	or	CC
cord-333722-ndth5zne	286	21	reduce	reduce	VB
cord-333722-ndth5zne	286	22	viral	viral	JJ
cord-333722-ndth5zne	286	23	replication	replication	NN
cord-333722-ndth5zne	286	24	,	,	,
cord-333722-ndth5zne	286	25	will	will	MD
cord-333722-ndth5zne	286	26	be	be	VB
cord-333722-ndth5zne	286	27	particularly	particularly	RB
cord-333722-ndth5zne	286	28	noteworthy	noteworthy	JJ
cord-333722-ndth5zne	286	29	.	.	.
cord-333722-ndth5zne	287	1	Host	host	NN
cord-333722-ndth5zne	287	2	response	response	NN
cord-333722-ndth5zne	287	3	to	to	IN
cord-333722-ndth5zne	287	4	influenza	influenza	NN
cord-333722-ndth5zne	287	5	virus	virus	NN
cord-333722-ndth5zne	287	6	:	:	:
cord-333722-ndth5zne	287	7	protection	protection	NN
cord-333722-ndth5zne	287	8	versus	versus	IN
cord-333722-ndth5zne	287	9	immunopathology	immunopathology	NN
cord-333722-ndth5zne	287	10	Into	into	IN
cord-333722-ndth5zne	287	11	the	the	DT
cord-333722-ndth5zne	287	12	eye	eye	NN
cord-333722-ndth5zne	287	13	of	of	IN
cord-333722-ndth5zne	287	14	the	the	DT
cord-333722-ndth5zne	287	15	cytokine	cytokine	NN
cord-333722-ndth5zne	287	16	storm	storm	NN
cord-333722-ndth5zne	287	17	Endothelial	endothelial	NN
cord-333722-ndth5zne	287	18	cells	cell	NNS
cord-333722-ndth5zne	287	19	are	be	VBP
cord-333722-ndth5zne	287	20	central	central	JJ
cord-333722-ndth5zne	287	21	orchestrators	orchestrator	NNS
cord-333722-ndth5zne	287	22	of	of	IN
cord-333722-ndth5zne	287	23	cytokine	cytokine	NN
cord-333722-ndth5zne	287	24	amplification	amplification	NN
cord-333722-ndth5zne	287	25	during	during	IN
cord-333722-ndth5zne	287	26	influenza	influenza	NN
cord-333722-ndth5zne	287	27	virus	virus	NN
cord-333722-ndth5zne	287	28	infection	infection	NN
cord-333722-ndth5zne	288	1	A	a	DT
cord-333722-ndth5zne	288	2	question	question	NN
cord-333722-ndth5zne	288	3	of	of	IN
cord-333722-ndth5zne	288	4	selfpreservation	selfpreservation	NN
cord-333722-ndth5zne	288	5	:	:	:
cord-333722-ndth5zne	288	6	immunopathology	immunopathology	NN
cord-333722-ndth5zne	288	7	in	in	IN
cord-333722-ndth5zne	288	8	influenza	influenza	NN
cord-333722-ndth5zne	288	9	virus	virus	NN
cord-333722-ndth5zne	288	10	infection	infection	NN
cord-333722-ndth5zne	288	11	Integrated	integrate	VBN
cord-333722-ndth5zne	288	12	clinical	clinical	JJ
cord-333722-ndth5zne	288	13	,	,	,
cord-333722-ndth5zne	288	14	pathologic	pathologic	JJ
cord-333722-ndth5zne	288	15	,	,	,
cord-333722-ndth5zne	288	16	virologic	virologic	NN
cord-333722-ndth5zne	288	17	,	,	,
cord-333722-ndth5zne	288	18	and	and	CC
cord-333722-ndth5zne	288	19	transcriptomic	transcriptomic	JJ
cord-333722-ndth5zne	288	20	analysis	analysis	NN
cord-333722-ndth5zne	288	21	of	of	IN
cord-333722-ndth5zne	288	22	H5N1	H5N1	NNP
cord-333722-ndth5zne	288	23	influenza	influenza	NN
cord-333722-ndth5zne	288	24	virus	virus	NN
cord-333722-ndth5zne	288	25	-	-	HYPH
cord-333722-ndth5zne	288	26	induced	induce	VBN
cord-333722-ndth5zne	288	27	viral	viral	JJ
cord-333722-ndth5zne	288	28	pneumonia	pneumonia	NN
cord-333722-ndth5zne	288	29	in	in	IN
cord-333722-ndth5zne	288	30	the	the	DT
cord-333722-ndth5zne	288	31	rhesus	rhesus	NN
cord-333722-ndth5zne	288	32	macaque	macaque	NN
cord-333722-ndth5zne	288	33	Structured	structured	JJ
cord-333722-ndth5zne	288	34	regulation	regulation	NN
cord-333722-ndth5zne	288	35	of	of	IN
cord-333722-ndth5zne	288	36	inflammation	inflammation	NN
cord-333722-ndth5zne	288	37	during	during	IN
cord-333722-ndth5zne	288	38	respiratory	respiratory	JJ
cord-333722-ndth5zne	288	39	viral	viral	JJ
cord-333722-ndth5zne	288	40	infection	infection	NN
cord-333722-ndth5zne	288	41	Innate	innate	VBP
cord-333722-ndth5zne	288	42	immune	immune	JJ
cord-333722-ndth5zne	288	43	responses	response	NNS
cord-333722-ndth5zne	288	44	to	to	TO
cord-333722-ndth5zne	288	45	influenza	influenza	VB
cord-333722-ndth5zne	288	46	A	a	DT
cord-333722-ndth5zne	288	47	H5N1	H5N1	NNP
cord-333722-ndth5zne	288	48	:	:	:
cord-333722-ndth5zne	288	49	friend	friend	NN
cord-333722-ndth5zne	288	50	or	or	CC
cord-333722-ndth5zne	288	51	foe	foe	NN
cord-333722-ndth5zne	288	52	?	?	.
cord-333722-ndth5zne	289	1	Recognition	recognition	NN
cord-333722-ndth5zne	289	2	of	of	IN
cord-333722-ndth5zne	289	3	microorganisms	microorganism	NNS
cord-333722-ndth5zne	289	4	and	and	CC
cord-333722-ndth5zne	289	5	activation	activation	NN
cord-333722-ndth5zne	289	6	of	of	IN
cord-333722-ndth5zne	289	7	the	the	DT
cord-333722-ndth5zne	289	8	immune	immune	JJ
cord-333722-ndth5zne	289	9	response	response	NN
cord-333722-ndth5zne	290	1	A	a	DT
cord-333722-ndth5zne	290	2	calculated	calculated	JJ
cord-333722-ndth5zne	290	3	response	response	NN
cord-333722-ndth5zne	290	4	:	:	:
cord-333722-ndth5zne	290	5	control	control	NN
cord-333722-ndth5zne	290	6	of	of	IN
cord-333722-ndth5zne	290	7	inflammation	inflammation	NN
cord-333722-ndth5zne	290	8	by	by	IN
cord-333722-ndth5zne	290	9	the	the	DT
cord-333722-ndth5zne	290	10	innate	innate	JJ
cord-333722-ndth5zne	290	11	immune	immune	JJ
cord-333722-ndth5zne	290	12	system	system	NN
cord-333722-ndth5zne	290	13	Genetic	genetic	JJ
cord-333722-ndth5zne	290	14	insights	insight	NNS
cord-333722-ndth5zne	290	15	into	into	IN
cord-333722-ndth5zne	290	16	sepsis	sepsis	NN
cord-333722-ndth5zne	290	17	:	:	:
cord-333722-ndth5zne	291	1	what	what	WP
cord-333722-ndth5zne	291	2	have	have	VBP
cord-333722-ndth5zne	291	3	we	-PRON-	PRP
cord-333722-ndth5zne	291	4	learned	learn	VBN
cord-333722-ndth5zne	291	5	and	and	CC
cord-333722-ndth5zne	291	6	how	how	WRB
cord-333722-ndth5zne	291	7	will	will	MD
cord-333722-ndth5zne	291	8	it	-PRON-	PRP
cord-333722-ndth5zne	291	9	help	help	VB
cord-333722-ndth5zne	291	10	?	?	.
cord-333722-ndth5zne	292	1	Avian	avian	JJ
cord-333722-ndth5zne	292	2	influenza	influenza	NN
cord-333722-ndth5zne	292	3	A	a	NN
cord-333722-ndth5zne	292	4	(	(	-LRB-
cord-333722-ndth5zne	292	5	H5N1	H5N1	NNP
cord-333722-ndth5zne	292	6	)	)	-RRB-
cord-333722-ndth5zne	292	7	infection	infection	NN
cord-333722-ndth5zne	292	8	in	in	IN
cord-333722-ndth5zne	292	9	humans	human	NNS
cord-333722-ndth5zne	292	10	Cerebrospinal	cerebrospinal	NN
cord-333722-ndth5zne	292	11	fluid	fluid	NN
cord-333722-ndth5zne	292	12	and	and	CC
cord-333722-ndth5zne	292	13	serum	serum	NN
cord-333722-ndth5zne	292	14	levels	level	NNS
cord-333722-ndth5zne	292	15	of	of	IN
cord-333722-ndth5zne	292	16	cytokines	cytokine	NNS
cord-333722-ndth5zne	292	17	and	and	CC
cord-333722-ndth5zne	292	18	soluble	soluble	JJ
cord-333722-ndth5zne	292	19	tumor	tumor	NN
cord-333722-ndth5zne	292	20	necrosis	necrosis	NN
cord-333722-ndth5zne	292	21	factor	factor	NN
cord-333722-ndth5zne	292	22	receptor	receptor	NN
cord-333722-ndth5zne	292	23	in	in	IN
cord-333722-ndth5zne	292	24	influenza	influenza	NN
cord-333722-ndth5zne	292	25	virus	virus	NN
cord-333722-ndth5zne	292	26	-	-	HYPH
cord-333722-ndth5zne	292	27	associated	associate	VBN
cord-333722-ndth5zne	292	28	encephalopathy	encephalopathy	NN
cord-333722-ndth5zne	292	29	Disease	Disease	NNP
cord-333722-ndth5zne	292	30	severity	severity	NN
cord-333722-ndth5zne	292	31	is	be	VBZ
cord-333722-ndth5zne	292	32	associated	associate	VBN
cord-333722-ndth5zne	292	33	with	with	IN
cord-333722-ndth5zne	292	34	differential	differential	JJ
cord-333722-ndth5zne	292	35	gene	gene	NN
cord-333722-ndth5zne	292	36	expression	expression	NN
cord-333722-ndth5zne	292	37	at	at	IN
cord-333722-ndth5zne	292	38	the	the	DT
cord-333722-ndth5zne	292	39	early	early	JJ
cord-333722-ndth5zne	292	40	and	and	CC
cord-333722-ndth5zne	292	41	late	late	JJ
cord-333722-ndth5zne	292	42	phases	phase	NNS
cord-333722-ndth5zne	292	43	of	of	IN
cord-333722-ndth5zne	292	44	infection	infection	NN
cord-333722-ndth5zne	292	45	in	in	IN
cord-333722-ndth5zne	292	46	nonhuman	nonhuman	NN
cord-333722-ndth5zne	292	47	primates	primate	NNS
cord-333722-ndth5zne	292	48	infected	infect	VBN
cord-333722-ndth5zne	292	49	with	with	IN
cord-333722-ndth5zne	292	50	different	different	JJ
cord-333722-ndth5zne	292	51	H5N1	H5N1	NNP
cord-333722-ndth5zne	292	52	highly	highly	RB
cord-333722-ndth5zne	292	53	pathogenic	pathogenic	JJ
cord-333722-ndth5zne	292	54	avian	avian	JJ
cord-333722-ndth5zne	292	55	influenza	influenza	NN
cord-333722-ndth5zne	292	56	viruses	viruse	VBZ
cord-333722-ndth5zne	292	57	Lethal	lethal	JJ
cord-333722-ndth5zne	292	58	dissemination	dissemination	NN
cord-333722-ndth5zne	292	59	of	of	IN
cord-333722-ndth5zne	292	60	H5N1	H5N1	NNP
cord-333722-ndth5zne	292	61	influenza	influenza	NN
cord-333722-ndth5zne	292	62	virus	virus	NN
cord-333722-ndth5zne	292	63	is	be	VBZ
cord-333722-ndth5zne	292	64	associated	associate	VBN
cord-333722-ndth5zne	292	65	with	with	IN
cord-333722-ndth5zne	292	66	dysregulation	dysregulation	NN
cord-333722-ndth5zne	292	67	of	of	IN
cord-333722-ndth5zne	292	68	inflammation	inflammation	NN
cord-333722-ndth5zne	292	69	and	and	CC
cord-333722-ndth5zne	292	70	lipoxin	lipoxin	NNP
cord-333722-ndth5zne	292	71	signaling	signal	VBG
cord-333722-ndth5zne	292	72	in	in	IN
cord-333722-ndth5zne	292	73	a	a	DT
cord-333722-ndth5zne	292	74	mouse	mouse	NN
cord-333722-ndth5zne	292	75	model	model	NN
cord-333722-ndth5zne	292	76	of	of	IN
cord-333722-ndth5zne	292	77	infection	infection	NN
cord-333722-ndth5zne	292	78	Fatal	fatal	JJ
cord-333722-ndth5zne	292	79	outcome	outcome	NN
cord-333722-ndth5zne	292	80	of	of	IN
cord-333722-ndth5zne	292	81	human	human	JJ
cord-333722-ndth5zne	292	82	influenza	influenza	NN
cord-333722-ndth5zne	292	83	A	a	NN
cord-333722-ndth5zne	292	84	(	(	-LRB-
cord-333722-ndth5zne	292	85	H5N1	H5N1	NNP
cord-333722-ndth5zne	292	86	)	)	-RRB-
cord-333722-ndth5zne	292	87	is	be	VBZ
cord-333722-ndth5zne	292	88	associated	associate	VBN
cord-333722-ndth5zne	292	89	with	with	IN
cord-333722-ndth5zne	292	90	high	high	JJ
cord-333722-ndth5zne	292	91	viral	viral	JJ
cord-333722-ndth5zne	292	92	load	load	NN
cord-333722-ndth5zne	292	93	and	and	CC
cord-333722-ndth5zne	292	94	hypercytokinemia	hypercytokinemia	NN
cord-333722-ndth5zne	292	95	Contrasting	contrasting	JJ
cord-333722-ndth5zne	292	96	effects	effect	NNS
cord-333722-ndth5zne	292	97	of	of	IN
cord-333722-ndth5zne	292	98	CCR5	CCR5	NNP
cord-333722-ndth5zne	292	99	and	and	CC
cord-333722-ndth5zne	292	100	CCR2	CCR2	NNP
cord-333722-ndth5zne	292	101	deficiency	deficiency	NN
cord-333722-ndth5zne	292	102	in	in	IN
cord-333722-ndth5zne	292	103	the	the	DT
cord-333722-ndth5zne	292	104	pulmonary	pulmonary	JJ
cord-333722-ndth5zne	292	105	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	292	106	response	response	NN
cord-333722-ndth5zne	292	107	to	to	TO
cord-333722-ndth5zne	292	108	influenza	influenza	VB
cord-333722-ndth5zne	292	109	A	a	DT
cord-333722-ndth5zne	292	110	virus	virus	NN
cord-333722-ndth5zne	292	111	Characterizing	characterize	VBG
cord-333722-ndth5zne	292	112	and	and	CC
cord-333722-ndth5zne	292	113	controlling	control	VBG
cord-333722-ndth5zne	292	114	the	the	DT
cord-333722-ndth5zne	292	115	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	292	116	network	network	NN
cord-333722-ndth5zne	292	117	during	during	IN
cord-333722-ndth5zne	292	118	influenza	influenza	NN
cord-333722-ndth5zne	292	119	A	a	DT
cord-333722-ndth5zne	292	120	virus	virus	NN
cord-333722-ndth5zne	292	121	infection	infection	NN
cord-333722-ndth5zne	292	122	Role	role	NN
cord-333722-ndth5zne	292	123	of	of	IN
cord-333722-ndth5zne	292	124	alveolar	alveolar	JJ
cord-333722-ndth5zne	292	125	epithelial	epithelial	JJ
cord-333722-ndth5zne	292	126	early	early	JJ
cord-333722-ndth5zne	292	127	growth	growth	NN
cord-333722-ndth5zne	292	128	response-1	response-1	NNP
cord-333722-ndth5zne	293	1	(	(	-LRB-
cord-333722-ndth5zne	293	2	Egr-1	Egr-1	NNP
cord-333722-ndth5zne	293	3	)	)	-RRB-
cord-333722-ndth5zne	293	4	in	in	IN
cord-333722-ndth5zne	293	5	CD8	CD8	NNP
cord-333722-ndth5zne	293	6	1	1	CD
cord-333722-ndth5zne	293	7	T	T	NNP
cord-333722-ndth5zne	293	8	cellmediated	cellmediate	VBN
cord-333722-ndth5zne	293	9	lung	lung	NN
cord-333722-ndth5zne	293	10	injury	injury	NN
cord-333722-ndth5zne	293	11	Th1	Th1	NNP
cord-333722-ndth5zne	293	12	and	and	CC
cord-333722-ndth5zne	293	13	Th17	Th17	NNP
cord-333722-ndth5zne	293	14	hypercytokinemia	hypercytokinemia	NNP
cord-333722-ndth5zne	293	15	as	as	IN
cord-333722-ndth5zne	293	16	early	early	JJ
cord-333722-ndth5zne	293	17	host	host	NN
cord-333722-ndth5zne	293	18	response	response	NN
cord-333722-ndth5zne	293	19	signature	signature	NN
cord-333722-ndth5zne	293	20	in	in	IN
cord-333722-ndth5zne	293	21	severe	severe	JJ
cord-333722-ndth5zne	293	22	pandemic	pandemic	NN
cord-333722-ndth5zne	293	23	influenza	influenza	NN
cord-333722-ndth5zne	293	24	Antigen	antigen	NN
cord-333722-ndth5zne	293	25	-	-	HYPH
cord-333722-ndth5zne	293	26	specific	specific	JJ
cord-333722-ndth5zne	293	27	memory	memory	NN
cord-333722-ndth5zne	293	28	regulatory	regulatory	JJ
cord-333722-ndth5zne	293	29	CD4	CD4	NNP
cord-333722-ndth5zne	293	30	1	1	CD
cord-333722-ndth5zne	293	31	Foxp	Foxp	NNP
cord-333722-ndth5zne	293	32	31	31	CD
cord-333722-ndth5zne	293	33	T	t	NN
cord-333722-ndth5zne	293	34	cells	cell	NNS
cord-333722-ndth5zne	293	35	control	control	VBP
cord-333722-ndth5zne	293	36	memory	memory	NN
cord-333722-ndth5zne	293	37	responses	response	NNS
cord-333722-ndth5zne	293	38	to	to	IN
cord-333722-ndth5zne	293	39	influenza	influenza	NN
cord-333722-ndth5zne	293	40	virus	virus	NN
cord-333722-ndth5zne	293	41	infection	infection	NN
cord-333722-ndth5zne	293	42	Immunomodulatory	Immunomodulatory	NNP
cord-333722-ndth5zne	293	43	therapy	therapy	NN
cord-333722-ndth5zne	293	44	for	for	IN
cord-333722-ndth5zne	293	45	severe	severe	JJ
cord-333722-ndth5zne	293	46	influenza	influenza	NN
cord-333722-ndth5zne	294	1	Early	early	JJ
cord-333722-ndth5zne	294	2	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	294	3	in	in	IN
cord-333722-ndth5zne	294	4	severe	severe	JJ
cord-333722-ndth5zne	294	5	influenza	influenza	NN
cord-333722-ndth5zne	294	6	A	A	NNP
cord-333722-ndth5zne	294	7	/	/	SYM
cord-333722-ndth5zne	294	8	H1N1	H1N1	NNP
cord-333722-ndth5zne	294	9	pneumonia	pneumonia	NN
cord-333722-ndth5zne	294	10	and	and	CC
cord-333722-ndth5zne	294	11	acute	acute	JJ
cord-333722-ndth5zne	294	12	respiratory	respiratory	JJ
cord-333722-ndth5zne	294	13	distress	distress	NN
cord-333722-ndth5zne	294	14	syndrome	syndrome	NN
cord-333722-ndth5zne	295	1	Clinical	clinical	JJ
cord-333722-ndth5zne	295	2	findings	finding	NNS
cord-333722-ndth5zne	295	3	in	in	IN
cord-333722-ndth5zne	295	4	111	111	CD
cord-333722-ndth5zne	295	5	cases	case	NNS
cord-333722-ndth5zne	295	6	of	of	IN
cord-333722-ndth5zne	295	7	influenza	influenza	NN
cord-333722-ndth5zne	295	8	A	a	NN
cord-333722-ndth5zne	295	9	(	(	-LRB-
cord-333722-ndth5zne	295	10	H7N9	H7N9	NNP
cord-333722-ndth5zne	295	11	)	)	-RRB-
cord-333722-ndth5zne	295	12	virus	virus	NN
cord-333722-ndth5zne	295	13	infection	infection	NN
cord-333722-ndth5zne	295	14	Effect	effect	NN
cord-333722-ndth5zne	295	15	of	of	IN
cord-333722-ndth5zne	295	16	dexamethasone	dexamethasone	NN
cord-333722-ndth5zne	295	17	on	on	IN
cord-333722-ndth5zne	295	18	acute	acute	JJ
cord-333722-ndth5zne	295	19	respiratory	respiratory	JJ
cord-333722-ndth5zne	295	20	distress	distress	NN
cord-333722-ndth5zne	295	21	syndrome	syndrome	NN
cord-333722-ndth5zne	295	22	induced	induce	VBN
cord-333722-ndth5zne	295	23	by	by	IN
cord-333722-ndth5zne	295	24	the	the	DT
cord-333722-ndth5zne	295	25	H5N1	H5N1	NNP
cord-333722-ndth5zne	295	26	virus	virus	NN
cord-333722-ndth5zne	295	27	in	in	IN
cord-333722-ndth5zne	295	28	mice	mouse	NNS
cord-333722-ndth5zne	295	29	Systemic	systemic	JJ
cord-333722-ndth5zne	295	30	corticosteroids	corticosteroid	NNS
cord-333722-ndth5zne	295	31	and	and	CC
cord-333722-ndth5zne	295	32	early	early	JJ
cord-333722-ndth5zne	295	33	administration	administration	NN
cord-333722-ndth5zne	295	34	of	of	IN
cord-333722-ndth5zne	295	35	antiviral	antiviral	JJ
cord-333722-ndth5zne	295	36	agents	agent	NNS
cord-333722-ndth5zne	295	37	for	for	IN
cord-333722-ndth5zne	295	38	pneumonia	pneumonia	NN
cord-333722-ndth5zne	295	39	with	with	IN
cord-333722-ndth5zne	295	40	acute	acute	JJ
cord-333722-ndth5zne	295	41	wheezing	wheeze	VBG
cord-333722-ndth5zne	295	42	due	due	IN
cord-333722-ndth5zne	295	43	to	to	IN
cord-333722-ndth5zne	295	44	influenza	influenza	NN
cord-333722-ndth5zne	295	45	A(H1N1)pdm09	A(H1N1)pdm09	NNP
cord-333722-ndth5zne	295	46	in	in	IN
cord-333722-ndth5zne	295	47	Japan	Japan	NNP
cord-333722-ndth5zne	295	48	Increased	increase	VBN
cord-333722-ndth5zne	295	49	survival	survival	NN
cord-333722-ndth5zne	295	50	after	after	IN
cord-333722-ndth5zne	295	51	gemfibrozil	gemfibrozil	NN
cord-333722-ndth5zne	295	52	treatment	treatment	NN
cord-333722-ndth5zne	295	53	of	of	IN
cord-333722-ndth5zne	295	54	severe	severe	JJ
cord-333722-ndth5zne	295	55	mouse	mouse	NN
cord-333722-ndth5zne	295	56	influenza	influenza	NN
cord-333722-ndth5zne	295	57	Delayed	delay	VBN
cord-333722-ndth5zne	295	58	antiviral	antiviral	JJ
cord-333722-ndth5zne	295	59	plus	plus	CC
cord-333722-ndth5zne	295	60	immunomodulator	immunomodulator	NNP
cord-333722-ndth5zne	295	61	treatment	treatment	NN
cord-333722-ndth5zne	295	62	still	still	RB
cord-333722-ndth5zne	295	63	reduces	reduce	VBZ
cord-333722-ndth5zne	295	64	mortality	mortality	NN
cord-333722-ndth5zne	295	65	in	in	IN
cord-333722-ndth5zne	295	66	mice	mouse	NNS
cord-333722-ndth5zne	295	67	infected	infect	VBN
cord-333722-ndth5zne	295	68	by	by	IN
cord-333722-ndth5zne	295	69	high	high	JJ
cord-333722-ndth5zne	295	70	inoculum	inoculum	NN
cord-333722-ndth5zne	295	71	of	of	IN
cord-333722-ndth5zne	295	72	influenza	influenza	NN
cord-333722-ndth5zne	295	73	A	A	NNP
cord-333722-ndth5zne	295	74	/	/	SYM
cord-333722-ndth5zne	295	75	H5N1	H5N1	NNP
cord-333722-ndth5zne	295	76	virus	virus	NN
cord-333722-ndth5zne	296	1	Bezafibrate	Bezafibrate	NNP
cord-333722-ndth5zne	296	2	upregulates	upregulate	VBZ
cord-333722-ndth5zne	296	3	carnitine	carnitine	NN
cord-333722-ndth5zne	296	4	palmitoyltransferase	palmitoyltransferase	NN
cord-333722-ndth5zne	296	5	II	ii	CD
cord-333722-ndth5zne	296	6	expression	expression	NN
cord-333722-ndth5zne	296	7	and	and	CC
cord-333722-ndth5zne	296	8	promotes	promote	VBZ
cord-333722-ndth5zne	296	9	mitochondrial	mitochondrial	JJ
cord-333722-ndth5zne	296	10	energy	energy	NN
cord-333722-ndth5zne	296	11	crisis	crisis	NN
cord-333722-ndth5zne	296	12	dissipation	dissipation	NN
cord-333722-ndth5zne	296	13	in	in	IN
cord-333722-ndth5zne	296	14	fibroblasts	fibroblast	NNS
cord-333722-ndth5zne	296	15	of	of	IN
cord-333722-ndth5zne	296	16	patients	patient	NNS
cord-333722-ndth5zne	296	17	with	with	IN
cord-333722-ndth5zne	296	18	influenza	influenza	NN
cord-333722-ndth5zne	296	19	-	-	HYPH
cord-333722-ndth5zne	296	20	associated	associate	VBN
cord-333722-ndth5zne	296	21	encephalopathy	encephalopathy	NN
cord-333722-ndth5zne	296	22	PPARgamma	PPARgamma	NNP
cord-333722-ndth5zne	296	23	activation	activation	NN
cord-333722-ndth5zne	296	24	as	as	IN
cord-333722-ndth5zne	296	25	an	an	DT
cord-333722-ndth5zne	296	26	anti	anti	JJ
cord-333722-ndth5zne	296	27	-	-	JJ
cord-333722-ndth5zne	296	28	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	296	29	therapy	therapy	NN
cord-333722-ndth5zne	296	30	for	for	IN
cord-333722-ndth5zne	296	31	respiratory	respiratory	JJ
cord-333722-ndth5zne	296	32	virus	virus	NN
cord-333722-ndth5zne	296	33	infections	infection	NNS
cord-333722-ndth5zne	296	34	Using	use	VBG
cord-333722-ndth5zne	296	35	complementary	complementary	JJ
cord-333722-ndth5zne	296	36	and	and	CC
cord-333722-ndth5zne	296	37	alternative	alternative	JJ
cord-333722-ndth5zne	296	38	medicines	medicine	NNS
cord-333722-ndth5zne	296	39	to	to	TO
cord-333722-ndth5zne	296	40	target	target	VB
cord-333722-ndth5zne	296	41	the	the	DT
cord-333722-ndth5zne	296	42	host	host	NN
cord-333722-ndth5zne	296	43	response	response	NN
cord-333722-ndth5zne	296	44	during	during	IN
cord-333722-ndth5zne	296	45	severe	severe	JJ
cord-333722-ndth5zne	296	46	influenza	influenza	NN
cord-333722-ndth5zne	297	1	Dissecting	dissect	VBG
cord-333722-ndth5zne	297	2	influenza	influenza	NN
cord-333722-ndth5zne	297	3	virus	virus	NN
cord-333722-ndth5zne	297	4	pathogenesis	pathogenesis	NN
cord-333722-ndth5zne	297	5	uncovers	uncover	VBZ
cord-333722-ndth5zne	297	6	a	a	DT
cord-333722-ndth5zne	297	7	novel	novel	JJ
cord-333722-ndth5zne	297	8	chemical	chemical	NN
cord-333722-ndth5zne	297	9	approach	approach	NN
cord-333722-ndth5zne	297	10	to	to	TO
cord-333722-ndth5zne	297	11	combat	combat	VB
cord-333722-ndth5zne	297	12	the	the	DT
cord-333722-ndth5zne	297	13	infection	infection	NN
cord-333722-ndth5zne	297	14	Pharmacologic	Pharmacologic	NNP
cord-333722-ndth5zne	297	15	inhibition	inhibition	NN
cord-333722-ndth5zne	297	16	of	of	IN
cord-333722-ndth5zne	297	17	COX-1	COX-1	NNP
cord-333722-ndth5zne	297	18	and	and	CC
cord-333722-ndth5zne	297	19	COX-2	COX-2	NNP
cord-333722-ndth5zne	297	20	in	in	IN
cord-333722-ndth5zne	297	21	influenza	influenza	NN
cord-333722-ndth5zne	297	22	A	a	DT
cord-333722-ndth5zne	297	23	viral	viral	JJ
cord-333722-ndth5zne	297	24	infection	infection	NN
cord-333722-ndth5zne	297	25	in	in	IN
cord-333722-ndth5zne	297	26	mice	mice	NN
cord-333722-ndth5zne	297	27	Drugs	drug	NNS
cord-333722-ndth5zne	297	28	to	to	TO
cord-333722-ndth5zne	297	29	cure	cure	VB
cord-333722-ndth5zne	297	30	avian	avian	JJ
cord-333722-ndth5zne	297	31	influenza	influenza	NN
cord-333722-ndth5zne	297	32	infection	infection	NN
cord-333722-ndth5zne	297	33	-multiple	-multiple	CD
cord-333722-ndth5zne	297	34	ways	way	NNS
cord-333722-ndth5zne	297	35	to	to	TO
cord-333722-ndth5zne	297	36	prevent	prevent	VB
cord-333722-ndth5zne	297	37	cell	cell	NN
cord-333722-ndth5zne	297	38	death	death	NN
cord-333722-ndth5zne	297	39	N	n	CD
cord-333722-ndth5zne	297	40	-	-	HYPH
cord-333722-ndth5zne	297	41	acetyl	acetyl	NNP
cord-333722-ndth5zne	297	42	-	-	HYPH
cord-333722-ndth5zne	297	43	L	l	NN
cord-333722-ndth5zne	297	44	-	-	HYPH
cord-333722-ndth5zne	297	45	cysteine	cysteine	NN
cord-333722-ndth5zne	297	46	(	(	-LRB-
cord-333722-ndth5zne	297	47	NAC	NAC	NNP
cord-333722-ndth5zne	297	48	)	)	-RRB-
cord-333722-ndth5zne	297	49	inhibits	inhibit	VBZ
cord-333722-ndth5zne	297	50	virus	virus	NN
cord-333722-ndth5zne	297	51	replication	replication	NN
cord-333722-ndth5zne	297	52	and	and	CC
cord-333722-ndth5zne	297	53	expression	expression	NN
cord-333722-ndth5zne	297	54	of	of	IN
cord-333722-ndth5zne	297	55	pro	pro	JJ
cord-333722-ndth5zne	297	56	-	-	JJ
cord-333722-ndth5zne	297	57	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	297	58	molecules	molecule	NNS
cord-333722-ndth5zne	297	59	in	in	IN
cord-333722-ndth5zne	297	60	A549	a549	JJ
cord-333722-ndth5zne	297	61	cells	cell	NNS
cord-333722-ndth5zne	297	62	infected	infect	VBN
cord-333722-ndth5zne	297	63	with	with	IN
cord-333722-ndth5zne	297	64	highly	highly	RB
cord-333722-ndth5zne	297	65	pathogenic	pathogenic	JJ
cord-333722-ndth5zne	297	66	H5N1	H5N1	NNP
cord-333722-ndth5zne	298	1	influenza	influenza	NN
cord-333722-ndth5zne	298	2	A	a	DT
cord-333722-ndth5zne	298	3	virus	virus	NN
cord-333722-ndth5zne	299	1	Glycyrrhizin	Glycyrrhizin	NNP
cord-333722-ndth5zne	299	2	exerts	exert	VBZ
cord-333722-ndth5zne	299	3	antioxidative	antioxidative	JJ
cord-333722-ndth5zne	299	4	effects	effect	NNS
cord-333722-ndth5zne	299	5	in	in	IN
cord-333722-ndth5zne	299	6	H5N1	H5N1	NNP
cord-333722-ndth5zne	299	7	influenza	influenza	NN
cord-333722-ndth5zne	299	8	A	a	DT
cord-333722-ndth5zne	299	9	virusinfected	virusinfecte	VBN
cord-333722-ndth5zne	299	10	cells	cell	NNS
cord-333722-ndth5zne	299	11	and	and	CC
cord-333722-ndth5zne	299	12	inhibits	inhibit	VBZ
cord-333722-ndth5zne	299	13	virus	virus	NN
cord-333722-ndth5zne	299	14	replication	replication	NN
cord-333722-ndth5zne	299	15	and	and	CC
cord-333722-ndth5zne	299	16	pro	pro	JJ
cord-333722-ndth5zne	299	17	-	-	JJ
cord-333722-ndth5zne	299	18	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	299	19	gene	gene	NN
cord-333722-ndth5zne	299	20	expression	expression	NN
cord-333722-ndth5zne	299	21	Ascorbic	ascorbic	NN
cord-333722-ndth5zne	299	22	acid	acid	NN
cord-333722-ndth5zne	299	23	role	role	NN
cord-333722-ndth5zne	299	24	in	in	IN
cord-333722-ndth5zne	299	25	containment	containment	NN
cord-333722-ndth5zne	299	26	of	of	IN
cord-333722-ndth5zne	299	27	the	the	DT
cord-333722-ndth5zne	299	28	world	world	NN
cord-333722-ndth5zne	299	29	avian	avian	JJ
cord-333722-ndth5zne	299	30	flu	flu	NN
cord-333722-ndth5zne	299	31	pandemic	pandemic	NN
cord-333722-ndth5zne	299	32	Inhibition	inhibition	NN
cord-333722-ndth5zne	299	33	of	of	IN
cord-333722-ndth5zne	299	34	influenza	influenza	NN
cord-333722-ndth5zne	299	35	A	a	DT
cord-333722-ndth5zne	299	36	virus	virus	NN
cord-333722-ndth5zne	299	37	replication	replication	NN
cord-333722-ndth5zne	299	38	by	by	IN
cord-333722-ndth5zne	299	39	resveratrol	resveratrol	NN
cord-333722-ndth5zne	299	40	Effects	effect	NNS
cord-333722-ndth5zne	299	41	of	of	IN
cord-333722-ndth5zne	299	42	flavonoid	flavonoid	NN
cord-333722-ndth5zne	299	43	-	-	HYPH
cord-333722-ndth5zne	299	44	induced	induce	VBN
cord-333722-ndth5zne	299	45	oxidative	oxidative	JJ
cord-333722-ndth5zne	299	46	stress	stress	NN
cord-333722-ndth5zne	299	47	on	on	IN
cord-333722-ndth5zne	299	48	anti	anti	NNP
cord-333722-ndth5zne	299	49	-	-	JJ
cord-333722-ndth5zne	299	50	H5N1	H5N1	NNP
cord-333722-ndth5zne	299	51	influenza	influenza	NN
cord-333722-ndth5zne	299	52	a	a	DT
cord-333722-ndth5zne	299	53	virus	virus	NN
cord-333722-ndth5zne	299	54	activity	activity	NN
cord-333722-ndth5zne	299	55	exerted	exert	VBN
cord-333722-ndth5zne	299	56	by	by	IN
cord-333722-ndth5zne	299	57	baicalein	baicalein	NNP
cord-333722-ndth5zne	299	58	and	and	CC
cord-333722-ndth5zne	299	59	biochanin	biochanin	NNP
cord-333722-ndth5zne	300	1	A	a	DT
cord-333722-ndth5zne	300	2	Nrf2	Nrf2	NNP
cord-333722-ndth5zne	300	3	expression	expression	NN
cord-333722-ndth5zne	300	4	modifies	modify	VBZ
cord-333722-ndth5zne	300	5	influenza	influenza	NN
cord-333722-ndth5zne	300	6	A	a	DT
cord-333722-ndth5zne	300	7	entry	entry	NN
cord-333722-ndth5zne	300	8	and	and	CC
cord-333722-ndth5zne	300	9	replication	replication	NN
cord-333722-ndth5zne	300	10	in	in	IN
cord-333722-ndth5zne	300	11	nasal	nasal	JJ
cord-333722-ndth5zne	300	12	epithelial	epithelial	JJ
cord-333722-ndth5zne	300	13	cells	cell	NNS
cord-333722-ndth5zne	300	14	N	n	CD
cord-333722-ndth5zne	300	15	-	-	HYPH
cord-333722-ndth5zne	300	16	acetylcysteine	acetylcysteine	NN
cord-333722-ndth5zne	300	17	synergizes	synergize	VBZ
cord-333722-ndth5zne	300	18	with	with	IN
cord-333722-ndth5zne	300	19	oseltamivir	oseltamivir	NNS
cord-333722-ndth5zne	300	20	in	in	IN
cord-333722-ndth5zne	300	21	protecting	protect	VBG
cord-333722-ndth5zne	300	22	mice	mouse	NNS
cord-333722-ndth5zne	300	23	from	from	IN
cord-333722-ndth5zne	300	24	lethal	lethal	JJ
cord-333722-ndth5zne	300	25	influenza	influenza	NN
cord-333722-ndth5zne	300	26	infection	infection	NN
cord-333722-ndth5zne	300	27	Pathogenesis	Pathogenesis	NNP
cord-333722-ndth5zne	300	28	of	of	IN
cord-333722-ndth5zne	300	29	septic	septic	JJ
cord-333722-ndth5zne	300	30	shock	shock	NN
cord-333722-ndth5zne	300	31	in	in	IN
cord-333722-ndth5zne	300	32	Pseudomonas	Pseudomonas	NNP
cord-333722-ndth5zne	300	33	aeruginosa	aeruginosa	VBZ
cord-333722-ndth5zne	300	34	pneumonia	pneumonia	NN
cord-333722-ndth5zne	300	35	Inhibition	inhibition	NN
cord-333722-ndth5zne	300	36	of	of	IN
cord-333722-ndth5zne	300	37	the	the	DT
cord-333722-ndth5zne	300	38	cytokine	cytokine	NN
cord-333722-ndth5zne	300	39	response	response	NN
cord-333722-ndth5zne	300	40	does	do	VBZ
cord-333722-ndth5zne	300	41	not	not	RB
cord-333722-ndth5zne	300	42	protect	protect	VB
cord-333722-ndth5zne	300	43	against	against	IN
cord-333722-ndth5zne	300	44	lethal	lethal	JJ
cord-333722-ndth5zne	300	45	H5N1	H5N1	NNP
cord-333722-ndth5zne	300	46	influenza	influenza	NN
cord-333722-ndth5zne	300	47	infection	infection	NN
cord-333722-ndth5zne	300	48	Role	role	NN
cord-333722-ndth5zne	300	49	of	of	IN
cord-333722-ndth5zne	300	50	host	host	NN
cord-333722-ndth5zne	300	51	cytokine	cytokine	NN
cord-333722-ndth5zne	300	52	responses	response	NNS
cord-333722-ndth5zne	300	53	in	in	IN
cord-333722-ndth5zne	300	54	the	the	DT
cord-333722-ndth5zne	300	55	pathogenesis	pathogenesis	NN
cord-333722-ndth5zne	300	56	of	of	IN
cord-333722-ndth5zne	300	57	avian	avian	JJ
cord-333722-ndth5zne	300	58	H5N1	H5N1	NNP
cord-333722-ndth5zne	300	59	influenza	influenza	NN
cord-333722-ndth5zne	300	60	viruses	virus	NNS
cord-333722-ndth5zne	300	61	in	in	IN
cord-333722-ndth5zne	300	62	mice	mouse	NNS
cord-333722-ndth5zne	300	63	Mechanisms	Mechanisms	NNPS
cord-333722-ndth5zne	300	64	of	of	IN
cord-333722-ndth5zne	300	65	action	action	NN
cord-333722-ndth5zne	300	66	of	of	IN
cord-333722-ndth5zne	300	67	intravenous	intravenous	JJ
cord-333722-ndth5zne	300	68	immunoglobulin	immunoglobulin	NN
cord-333722-ndth5zne	300	69	in	in	IN
cord-333722-ndth5zne	300	70	autoimmune	autoimmune	JJ
cord-333722-ndth5zne	300	71	and	and	CC
cord-333722-ndth5zne	300	72	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	300	73	diseases	disease	NNS
cord-333722-ndth5zne	301	1	Hyperimmune	Hyperimmune	NNP
cord-333722-ndth5zne	301	2	IV	IV	NNP
cord-333722-ndth5zne	301	3	immunoglobulin	immunoglobulin	NN
cord-333722-ndth5zne	301	4	treatment	treatment	NN
cord-333722-ndth5zne	301	5	:	:	:
cord-333722-ndth5zne	301	6	a	a	DT
cord-333722-ndth5zne	301	7	multicenter	multicenter	JJ
cord-333722-ndth5zne	301	8	double	double	JJ
cord-333722-ndth5zne	301	9	-	-	HYPH
cord-333722-ndth5zne	301	10	blind	blind	JJ
cord-333722-ndth5zne	301	11	randomized	randomize	VBN
cord-333722-ndth5zne	301	12	controlled	control	VBN
cord-333722-ndth5zne	301	13	trial	trial	NN
cord-333722-ndth5zne	301	14	for	for	IN
cord-333722-ndth5zne	301	15	patients	patient	NNS
cord-333722-ndth5zne	301	16	with	with	IN
cord-333722-ndth5zne	301	17	severe	severe	JJ
cord-333722-ndth5zne	301	18	2009	2009	CD
cord-333722-ndth5zne	301	19	influenza	influenza	NN
cord-333722-ndth5zne	301	20	A(H1N1	a(h1n1	NN
cord-333722-ndth5zne	301	21	)	)	-RRB-
cord-333722-ndth5zne	301	22	infection	infection	NN
cord-333722-ndth5zne	301	23	Analysis	analysis	NN
cord-333722-ndth5zne	301	24	of	of	IN
cord-333722-ndth5zne	301	25	deaths	death	NNS
cord-333722-ndth5zne	301	26	during	during	IN
cord-333722-ndth5zne	301	27	the	the	DT
cord-333722-ndth5zne	301	28	severe	severe	JJ
cord-333722-ndth5zne	301	29	acute	acute	JJ
cord-333722-ndth5zne	301	30	respiratory	respiratory	JJ
cord-333722-ndth5zne	301	31	syndrome	syndrome	NN
cord-333722-ndth5zne	301	32	(	(	-LRB-
cord-333722-ndth5zne	301	33	SARS	SARS	NNP
cord-333722-ndth5zne	301	34	)	)	-RRB-
cord-333722-ndth5zne	301	35	epidemic	epidemic	NN
cord-333722-ndth5zne	301	36	in	in	IN
cord-333722-ndth5zne	301	37	Singapore	Singapore	NNP
cord-333722-ndth5zne	301	38	:	:	:
cord-333722-ndth5zne	301	39	challenges	challenge	NNS
cord-333722-ndth5zne	301	40	in	in	IN
cord-333722-ndth5zne	301	41	determining	determine	VBG
cord-333722-ndth5zne	301	42	a	a	DT
cord-333722-ndth5zne	301	43	SARS	SARS	NNP
cord-333722-ndth5zne	301	44	diagnosis	diagnosis	NN
cord-333722-ndth5zne	301	45	Meta	Meta	NNP
cord-333722-ndth5zne	301	46	-	-	HYPH
cord-333722-ndth5zne	301	47	analysis	analysis	NN
cord-333722-ndth5zne	301	48	:	:	:
cord-333722-ndth5zne	301	49	convalescent	convalescent	JJ
cord-333722-ndth5zne	301	50	blood	blood	NN
cord-333722-ndth5zne	301	51	products	product	NNS
cord-333722-ndth5zne	301	52	for	for	IN
cord-333722-ndth5zne	301	53	Spanish	spanish	JJ
cord-333722-ndth5zne	301	54	influenza	influenza	NN
cord-333722-ndth5zne	301	55	pneumonia	pneumonia	NN
cord-333722-ndth5zne	301	56	:	:	:
cord-333722-ndth5zne	301	57	a	a	DT
cord-333722-ndth5zne	301	58	future	future	JJ
cord-333722-ndth5zne	301	59	H5N1	H5N1	NNP
cord-333722-ndth5zne	301	60	treatment	treatment	NN
cord-333722-ndth5zne	301	61	?	?	.
cord-333722-ndth5zne	302	1	Treating	treat	VBG
cord-333722-ndth5zne	302	2	influenza	influenza	NN
cord-333722-ndth5zne	302	3	with	with	IN
cord-333722-ndth5zne	302	4	statins	statin	NNS
cord-333722-ndth5zne	302	5	and	and	CC
cord-333722-ndth5zne	302	6	other	other	JJ
cord-333722-ndth5zne	302	7	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	302	8	agents	agent	NNS
cord-333722-ndth5zne	302	9	Evaluation	Evaluation	NNP
cord-333722-ndth5zne	302	10	of	of	IN
cord-333722-ndth5zne	302	11	the	the	DT
cord-333722-ndth5zne	302	12	efficacy	efficacy	NN
cord-333722-ndth5zne	302	13	and	and	CC
cord-333722-ndth5zne	302	14	safety	safety	NN
cord-333722-ndth5zne	302	15	of	of	IN
cord-333722-ndth5zne	302	16	a	a	DT
cord-333722-ndth5zne	302	17	statin	statin	NN
cord-333722-ndth5zne	302	18	/	/	SYM
cord-333722-ndth5zne	302	19	caffeine	caffeine	NN
cord-333722-ndth5zne	302	20	combination	combination	NN
cord-333722-ndth5zne	302	21	against	against	IN
cord-333722-ndth5zne	302	22	H5N1	H5N1	NNP
cord-333722-ndth5zne	302	23	,	,	,
cord-333722-ndth5zne	302	24	H3N2	H3N2	NNP
cord-333722-ndth5zne	302	25	and	and	CC
cord-333722-ndth5zne	302	26	H1N1	H1N1	NNP
cord-333722-ndth5zne	302	27	virus	virus	NN
cord-333722-ndth5zne	302	28	infection	infection	NN
cord-333722-ndth5zne	302	29	in	in	IN
cord-333722-ndth5zne	302	30	BALB	BALB	NNP
cord-333722-ndth5zne	302	31	/	/	SYM
cord-333722-ndth5zne	302	32	c	c	NN
cord-333722-ndth5zne	302	33	mice	mouse	NNS
cord-333722-ndth5zne	302	34	Effect	Effect	NNP
cord-333722-ndth5zne	302	35	of	of	IN
cord-333722-ndth5zne	302	36	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	302	37	therapies	therapy	NNS
cord-333722-ndth5zne	302	38	in	in	IN
cord-333722-ndth5zne	302	39	patients	patient	NNS
cord-333722-ndth5zne	302	40	with	with	IN
cord-333722-ndth5zne	302	41	pandemic	pandemic	NN
cord-333722-ndth5zne	302	42	influenza	influenza	NN
cord-333722-ndth5zne	302	43	A	a	NN
cord-333722-ndth5zne	302	44	(	(	-LRB-
cord-333722-ndth5zne	302	45	H1N1	H1N1	NNP
cord-333722-ndth5zne	302	46	)	)	-RRB-
cord-333722-ndth5zne	302	47	2009	2009	CD
cord-333722-ndth5zne	302	48	complicated	complicate	VBN
cord-333722-ndth5zne	302	49	by	by	IN
cord-333722-ndth5zne	302	50	pneumonia	pneumonia	NN
cord-333722-ndth5zne	302	51	Potential	potential	JJ
cord-333722-ndth5zne	302	52	mechanisms	mechanism	NNS
cord-333722-ndth5zne	302	53	of	of	IN
cord-333722-ndth5zne	302	54	AT1	at1	NN
cord-333722-ndth5zne	302	55	receptor	receptor	NN
cord-333722-ndth5zne	302	56	blockers	blocker	NNS
cord-333722-ndth5zne	302	57	on	on	IN
cord-333722-ndth5zne	302	58	reducing	reduce	VBG
cord-333722-ndth5zne	302	59	pneumonia	pneumonia	NN
cord-333722-ndth5zne	302	60	-	-	HYPH
cord-333722-ndth5zne	302	61	related	relate	VBN
cord-333722-ndth5zne	302	62	mortality	mortality	NN
cord-333722-ndth5zne	302	63	Population	population	NN
cord-333722-ndth5zne	302	64	-	-	HYPH
cord-333722-ndth5zne	302	65	based	base	VBN
cord-333722-ndth5zne	302	66	study	study	NN
cord-333722-ndth5zne	302	67	of	of	IN
cord-333722-ndth5zne	302	68	statins	statin	NNS
cord-333722-ndth5zne	302	69	,	,	,
cord-333722-ndth5zne	302	70	angiotensin	angiotensin	NN
cord-333722-ndth5zne	302	71	II	ii	CD
cord-333722-ndth5zne	302	72	receptor	receptor	NN
cord-333722-ndth5zne	302	73	blockers	blocker	NNS
cord-333722-ndth5zne	302	74	,	,	,
cord-333722-ndth5zne	302	75	and	and	CC
cord-333722-ndth5zne	302	76	angiotensin	angiotensin	NN
cord-333722-ndth5zne	302	77	-	-	HYPH
cord-333722-ndth5zne	302	78	converting	convert	VBG
cord-333722-ndth5zne	302	79	enzyme	enzyme	NN
cord-333722-ndth5zne	302	80	inhibitors	inhibitor	NNS
cord-333722-ndth5zne	302	81	on	on	IN
cord-333722-ndth5zne	302	82	pneumonia	pneumonia	NN
cord-333722-ndth5zne	302	83	-	-	HYPH
cord-333722-ndth5zne	302	84	related	relate	VBN
cord-333722-ndth5zne	302	85	outcomes	outcome	NNS
cord-333722-ndth5zne	303	1	CCR2-antagonist	CCR2-antagonist	NNP
cord-333722-ndth5zne	303	2	prophylaxis	prophylaxis	NN
cord-333722-ndth5zne	303	3	reduces	reduce	VBZ
cord-333722-ndth5zne	303	4	pulmonary	pulmonary	JJ
cord-333722-ndth5zne	303	5	immune	immune	JJ
cord-333722-ndth5zne	303	6	pathology	pathology	NN
cord-333722-ndth5zne	303	7	and	and	CC
cord-333722-ndth5zne	303	8	markedly	markedly	RB
cord-333722-ndth5zne	303	9	improves	improve	VBZ
cord-333722-ndth5zne	303	10	survival	survival	NN
cord-333722-ndth5zne	303	11	during	during	IN
cord-333722-ndth5zne	303	12	influenza	influenza	NN
cord-333722-ndth5zne	303	13	infection	infection	NN
cord-333722-ndth5zne	303	14	Peroxisome	Peroxisome	NNP
cord-333722-ndth5zne	303	15	proliferatoractivated	proliferatoractivated	JJ
cord-333722-ndth5zne	303	16	receptor	receptor	NN
cord-333722-ndth5zne	303	17	and	and	CC
cord-333722-ndth5zne	303	18	AMP	amp	NN
cord-333722-ndth5zne	303	19	-	-	HYPH
cord-333722-ndth5zne	303	20	activated	activate	VBN
cord-333722-ndth5zne	303	21	protein	protein	NN
cord-333722-ndth5zne	303	22	kinase	kinase	NN
cord-333722-ndth5zne	303	23	agonists	agonist	NNS
cord-333722-ndth5zne	303	24	protect	protect	VBP
cord-333722-ndth5zne	303	25	against	against	IN
cord-333722-ndth5zne	303	26	lethal	lethal	JJ
cord-333722-ndth5zne	303	27	influenza	influenza	NN
cord-333722-ndth5zne	303	28	virus	virus	NN
cord-333722-ndth5zne	303	29	challenge	challenge	NN
cord-333722-ndth5zne	303	30	in	in	IN
cord-333722-ndth5zne	303	31	mice	mouse	NNS
cord-333722-ndth5zne	304	1	A	a	DT
cord-333722-ndth5zne	304	2	critical	critical	JJ
cord-333722-ndth5zne	304	3	role	role	NN
cord-333722-ndth5zne	304	4	for	for	IN
cord-333722-ndth5zne	304	5	OX40	OX40	NNP
cord-333722-ndth5zne	304	6	in	in	IN
cord-333722-ndth5zne	304	7	T	T	NNP
cord-333722-ndth5zne	304	8	cell	cell	NN
cord-333722-ndth5zne	304	9	-	-	HYPH
cord-333722-ndth5zne	304	10	mediated	mediate	VBN
cord-333722-ndth5zne	304	11	immunopathology	immunopathology	NN
cord-333722-ndth5zne	304	12	during	during	IN
cord-333722-ndth5zne	304	13	lung	lung	NN
cord-333722-ndth5zne	304	14	viral	viral	JJ
cord-333722-ndth5zne	304	15	infection	infection	NN
cord-333722-ndth5zne	304	16	Suppressor	Suppressor	NNP
cord-333722-ndth5zne	304	17	of	of	IN
cord-333722-ndth5zne	304	18	cytokine	cytokine	NN
cord-333722-ndth5zne	304	19	signaling	signal	VBG
cord-333722-ndth5zne	304	20	4	4	CD
cord-333722-ndth5zne	304	21	(	(	-LRB-
cord-333722-ndth5zne	304	22	SOCS4	socs4	NN
cord-333722-ndth5zne	304	23	)	)	-RRB-
cord-333722-ndth5zne	304	24	protects	protect	VBZ
cord-333722-ndth5zne	304	25	against	against	IN
cord-333722-ndth5zne	304	26	severe	severe	JJ
cord-333722-ndth5zne	304	27	cytokine	cytokine	NN
cord-333722-ndth5zne	304	28	storm	storm	NN
cord-333722-ndth5zne	304	29	and	and	CC
cord-333722-ndth5zne	304	30	enhances	enhance	VBZ
cord-333722-ndth5zne	304	31	viral	viral	JJ
cord-333722-ndth5zne	304	32	clearance	clearance	NN
cord-333722-ndth5zne	304	33	during	during	IN
cord-333722-ndth5zne	304	34	influenza	influenza	NN
cord-333722-ndth5zne	304	35	infection	infection	NN
cord-333722-ndth5zne	304	36	Macrolides	macrolide	NNS
cord-333722-ndth5zne	304	37	:	:	:
cord-333722-ndth5zne	304	38	from	from	IN
cord-333722-ndth5zne	304	39	in	in	IN
cord-333722-ndth5zne	304	40	vitro	vitro	FW
cord-333722-ndth5zne	304	41	anti	anti	JJ
cord-333722-ndth5zne	304	42	-	-	JJ
cord-333722-ndth5zne	304	43	inflammatory	inflammatory	JJ
cord-333722-ndth5zne	304	44	and	and	CC
cord-333722-ndth5zne	304	45	immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	304	46	properties	property	NNS
cord-333722-ndth5zne	304	47	to	to	IN
cord-333722-ndth5zne	304	48	clinical	clinical	JJ
cord-333722-ndth5zne	304	49	practice	practice	NN
cord-333722-ndth5zne	304	50	in	in	IN
cord-333722-ndth5zne	304	51	respiratory	respiratory	JJ
cord-333722-ndth5zne	304	52	diseases	disease	NNS
cord-333722-ndth5zne	304	53	Arbidol	Arbidol	NNP
cord-333722-ndth5zne	304	54	as	as	IN
cord-333722-ndth5zne	304	55	a	a	DT
cord-333722-ndth5zne	304	56	broad	broad	JJ
cord-333722-ndth5zne	304	57	-	-	HYPH
cord-333722-ndth5zne	304	58	spectrum	spectrum	NN
cord-333722-ndth5zne	304	59	antiviral	antiviral	NN
cord-333722-ndth5zne	304	60	:	:	:
cord-333722-ndth5zne	304	61	an	an	DT
cord-333722-ndth5zne	304	62	update	update	NN
cord-333722-ndth5zne	304	63	Antiviral	antiviral	JJ
cord-333722-ndth5zne	304	64	and	and	CC
cord-333722-ndth5zne	304	65	antiinflammatory	antiinflammatory	JJ
cord-333722-ndth5zne	304	66	activity	activity	NN
cord-333722-ndth5zne	304	67	of	of	IN
cord-333722-ndth5zne	304	68	arbidol	arbidol	NN
cord-333722-ndth5zne	304	69	hydrochloride	hydrochloride	NN
cord-333722-ndth5zne	304	70	in	in	IN
cord-333722-ndth5zne	304	71	influenza	influenza	NNP
cord-333722-ndth5zne	304	72	A	A	NNP
cord-333722-ndth5zne	304	73	(	(	-LRB-
cord-333722-ndth5zne	304	74	H1N1	H1N1	NNP
cord-333722-ndth5zne	304	75	)	)	-RRB-
cord-333722-ndth5zne	304	76	virus	virus	NN
cord-333722-ndth5zne	304	77	infection	infection	NN
cord-333722-ndth5zne	304	78	Guidelines	Guidelines	NNPS
cord-333722-ndth5zne	304	79	for	for	IN
cord-333722-ndth5zne	304	80	Management	Management	NNP
cord-333722-ndth5zne	304	81	of	of	IN
cord-333722-ndth5zne	304	82	Avian	Avian	NNP
cord-333722-ndth5zne	304	83	H7N9	H7N9	NNP
cord-333722-ndth5zne	304	84	Influenza	Influenza	NNP
cord-333722-ndth5zne	304	85	Infection	Infection	NNP
cord-333722-ndth5zne	304	86	Guidelines	Guidelines	NNPS
cord-333722-ndth5zne	304	87	for	for	IN
cord-333722-ndth5zne	304	88	Management	Management	NNP
cord-333722-ndth5zne	304	89	of	of	IN
cord-333722-ndth5zne	304	90	Pandemic	Pandemic	NNP
cord-333722-ndth5zne	304	91	(	(	-LRB-
cord-333722-ndth5zne	304	92	H1N1	H1N1	NNP
cord-333722-ndth5zne	304	93	)	)	-RRB-
cord-333722-ndth5zne	305	1	Chinese	chinese	JJ
cord-333722-ndth5zne	305	2	medicinal	medicinal	JJ
cord-333722-ndth5zne	305	3	herbs	herb	NNS
cord-333722-ndth5zne	305	4	for	for	IN
cord-333722-ndth5zne	305	5	influenza	influenza	NN
cord-333722-ndth5zne	306	1	:	:	:
cord-333722-ndth5zne	306	2	a	a	DT
cord-333722-ndth5zne	306	3	systematic	systematic	JJ
cord-333722-ndth5zne	306	4	review	review	NN
cord-333722-ndth5zne	307	1	Chinese	chinese	JJ
cord-333722-ndth5zne	307	2	herbal	herbal	JJ
cord-333722-ndth5zne	307	3	medicines	medicine	NNS
cord-333722-ndth5zne	307	4	for	for	IN
cord-333722-ndth5zne	307	5	the	the	DT
cord-333722-ndth5zne	307	6	treatment	treatment	NN
cord-333722-ndth5zne	307	7	of	of	IN
cord-333722-ndth5zne	307	8	type	type	NN
cord-333722-ndth5zne	307	9	A	a	DT
cord-333722-ndth5zne	307	10	H1N1	H1N1	NNP
cord-333722-ndth5zne	307	11	influenza	influenza	NN
cord-333722-ndth5zne	307	12	:	:	:
cord-333722-ndth5zne	307	13	a	a	DT
cord-333722-ndth5zne	307	14	systematic	systematic	JJ
cord-333722-ndth5zne	307	15	review	review	NN
cord-333722-ndth5zne	307	16	of	of	IN
cord-333722-ndth5zne	307	17	randomized	randomized	JJ
cord-333722-ndth5zne	307	18	controlled	control	VBN
cord-333722-ndth5zne	307	19	trials	trial	NNS
cord-333722-ndth5zne	307	20	Immunomodulatory	immunomodulatory	JJ
cord-333722-ndth5zne	307	21	effects	effect	NNS
cord-333722-ndth5zne	307	22	of	of	IN
cord-333722-ndth5zne	307	23	a	a	DT
cord-333722-ndth5zne	307	24	traditional	traditional	JJ
cord-333722-ndth5zne	307	25	Chinese	chinese	JJ
cord-333722-ndth5zne	307	26	medicine	medicine	NN
cord-333722-ndth5zne	307	27	with	with	IN
cord-333722-ndth5zne	307	28	potential	potential	JJ
cord-333722-ndth5zne	307	29	antiviral	antiviral	JJ
cord-333722-ndth5zne	307	30	activity	activity	NN
cord-333722-ndth5zne	307	31	:	:	:
cord-333722-ndth5zne	307	32	a	a	DT
cord-333722-ndth5zne	307	33	self	self	NN
cord-333722-ndth5zne	307	34	-	-	HYPH
cord-333722-ndth5zne	307	35	control	control	NN
cord-333722-ndth5zne	307	36	study	study	NN
cord-333722-ndth5zne	307	37	Jiawei	Jiawei	NNP
cord-333722-ndth5zne	307	38	-	-	HYPH
cord-333722-ndth5zne	307	39	Yupingfeng	Yupingfeng	NNP
cord-333722-ndth5zne	307	40	-	-	HYPH
cord-333722-ndth5zne	307	41	Tang	Tang	NNP
cord-333722-ndth5zne	307	42	,	,	,
cord-333722-ndth5zne	307	43	a	a	DT
cord-333722-ndth5zne	307	44	Chinese	chinese	JJ
cord-333722-ndth5zne	307	45	herbal	herbal	JJ
cord-333722-ndth5zne	307	46	formula	formula	NN
cord-333722-ndth5zne	307	47	,	,	,
cord-333722-ndth5zne	307	48	inhibits	inhibit	VBZ
cord-333722-ndth5zne	307	49	respiratory	respiratory	JJ
cord-333722-ndth5zne	307	50	viral	viral	JJ
cord-333722-ndth5zne	307	51	infections	infection	NNS
cord-333722-ndth5zne	307	52	in	in	IN
cord-333722-ndth5zne	307	53	vitro	vitro	FW
cord-333722-ndth5zne	307	54	and	and	CC
cord-333722-ndth5zne	307	55	in	in	IN
cord-333722-ndth5zne	307	56	vivo	vivo	NNP
cord-333722-ndth5zne	307	57	Amelioration	amelioration	NN
cord-333722-ndth5zne	307	58	of	of	IN
cord-333722-ndth5zne	307	59	influenza	influenza	NN
cord-333722-ndth5zne	307	60	virus	virus	NN
cord-333722-ndth5zne	307	61	-	-	HYPH
cord-333722-ndth5zne	307	62	induced	induce	VBN
cord-333722-ndth5zne	307	63	reactive	reactive	JJ
cord-333722-ndth5zne	307	64	oxygen	oxygen	NN
cord-333722-ndth5zne	307	65	species	specie	NNS
cord-333722-ndth5zne	307	66	formation	formation	NN
cord-333722-ndth5zne	307	67	by	by	IN
cord-333722-ndth5zne	307	68	epigallocatechin	epigallocatechin	NNP
cord-333722-ndth5zne	307	69	gallate	gallate	NNP
cord-333722-ndth5zne	307	70	derived	derive	VBN
cord-333722-ndth5zne	307	71	from	from	IN
cord-333722-ndth5zne	307	72	green	green	JJ
cord-333722-ndth5zne	307	73	tea	tea	NN
cord-333722-ndth5zne	308	1	We	-PRON-	PRP
cord-333722-ndth5zne	308	2	acknowledge	acknowledge	VBP
cord-333722-ndth5zne	308	3	research	research	NN
cord-333722-ndth5zne	308	4	funding	funding	NN
cord-333722-ndth5zne	308	5	from	from	IN
cord-333722-ndth5zne	308	6	the	the	DT
cord-333722-ndth5zne	308	7	National	National	NNP
cord-333722-ndth5zne	308	8	Nature	Nature	NNP
cord-333722-ndth5zne	308	9	Science	Science	NNP
cord-333722-ndth5zne	308	10	Foundation	Foundation	NNP
cord-333722-ndth5zne	308	11	of	of	IN
cord-333722-ndth5zne	308	12	China	China	NNP
cord-333722-ndth5zne	308	13	(	(	-LRB-
cord-333722-ndth5zne	308	14	Grant	Grant	NNP
cord-333722-ndth5zne	308	15	Nos	Nos	NNP
cord-333722-ndth5zne	308	16	.	.	.
cord-333722-ndth5zne	309	1	81403163	81403163	CD
cord-333722-ndth5zne	309	2	and	and	CC
cord-333722-ndth5zne	309	3	81402404	81402404	CD
cord-333722-ndth5zne	309	4	)	)	-RRB-
cord-333722-ndth5zne	309	5	and	and	CC
cord-333722-ndth5zne	309	6	Yi	Yi	NNP
cord-333722-ndth5zne	309	7	Chang	Chang	NNP
cord-333722-ndth5zne	309	8	Scientific	Scientific	NNP
cord-333722-ndth5zne	309	9	and	and	CC
cord-333722-ndth5zne	309	10	Technological	Technological	NNP
cord-333722-ndth5zne	309	11	Bureau	Bureau	NNP
cord-333722-ndth5zne	310	1	(	(	-LRB-
cord-333722-ndth5zne	310	2	Grant	Grant	NNP
cord-333722-ndth5zne	310	3	Nos	Nos	NNP
cord-333722-ndth5zne	310	4	.	.	.
cord-333722-ndth5zne	311	1	A14301	a14301	NN
cord-333722-ndth5zne	311	2	-	-	HYPH
cord-333722-ndth5zne	311	3	04	04	CD
cord-333722-ndth5zne	311	4	and	and	CC
cord-333722-ndth5zne	311	5	A14301	A14301	NNP
cord-333722-ndth5zne	311	6	-	-	HYPH
cord-333722-ndth5zne	311	7	10	10	CD
cord-333722-ndth5zne	311	8	)	)	-RRB-
cord-333722-ndth5zne	311	9	.	.	.