id author title date pages extension mime words sentences flesch summary cache txt cord-283349-9x2d1qip Paolino, Jonathan Peripheral blood smears of children with multisystem inflammatory syndrome demonstrate prominence of early myeloid forms with morphologic evidence of toxic change 2020-07-24 .txt text/plain 864 55 44 title: Peripheral blood smears of children with multisystem inflammatory syndrome demonstrate prominence of early myeloid forms with morphologic evidence of toxic change There is a growing body of evidence that suggests that children have largely been spared of much of the morbidity associated with the ongoing SARS-CoV-2 pandemic 1,2 Over the last several weeks, however, there has been an increasing awareness and understanding of a hyperinflammatory shock syndrome that appears to mimic some aspects of Kawasaki disease in some pediatric patients. While the role that neutrophils play in the development of Kawasaki disease continues to be clarified, it is described in the literature that higher neutrophil to lymphocyte ratios (NLRs) may portend an increased risk of resistance to treatment with intravenous immunoglobulin as well as development of coronary aneurysms 6, 7 Indeed, there is also evidence that suggests that higher NLRs in patients with COVID-19 are associated with increased levels of inflammation and clinical severity. ./cache/cord-283349-9x2d1qip.txt ./txt/cord-283349-9x2d1qip.txt