id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252686-viz05uam	Dong, Qing	A signal-flexible gene diagnostic strategy coupling loop-mediated isothermal amplification with hybridization chain reaction	2019-11-04		.txt	text/plain	5051	262	52	Abstract Recent study proves that the combination of loop mediated isothermal nucleic acid amplification (LAMP) with one-step strand displacement (OSD) is of great help to improve the sequence specificity during genetic detection. With the purpose of improving the detection specificity and achieving more simple and reliable readout, we recently developed an innovation in which one-step nucleic strand displacement reaction (usually shortened as OSD) was adapted, instead of traditional fluorescent intercalating dyes, to probe the products of isothermal amplifications (e.g., LAMP). These results exhibited the MBs based LAMP-HCR strategy realized robust NoV detection and was more resistant to interference than the real-time fluorescence assay, where the fluorescence signal could be decreased with the increased concentrations of fecal samples ( Fig. 1D and Fig. S6 , in SI).	./cache/cord-252686-viz05uam.txt	./txt/cord-252686-viz05uam.txt