id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016757-3d320c0a	nan	Acute and chronic liver insufficiency	2008		.txt	text/plain	9786	705	46	Hepatic coma can be subdivided according to its aetiology as follows: (1.) hepatocyte disintegration coma (ϭ endogenous coma due to the loss of parenchyma), (2 ( ( .) liver cell failure coma (ϭ exogenous coma due to metabolic disorders, almost always in the presence of cirrhosis), (3.) electrolyte coma (ϭ so-called "false" coma due to dyselectrolytaemia, almost always iatrogenic), and (4.) mixed forms of coma. Acute liver failure (ALF) is defined as an acute clinical picture with jaundice due to a most severe disorder in the liver function and/or massive liver cell necrosis which, without any pre-existing liver disease, culminates in hepatic coma (ϭ endogenous coma) within 8 weeks. 11) Consequently, severe damage to liver cells and widespread necrosis are usually the result of a network of altered cellular and humoral reactions, which for their part are often the initial cause of acute liver failure due to their synergistic and interactive effects (H. Fulminant hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation	./cache/cord-016757-3d320c0a.txt	./txt/cord-016757-3d320c0a.txt