id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002627-3jwu4pf2	Wu, Nan-Chun	Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation	2017-07-26		.txt	text/plain	8504	424	39	Cu/Zn SOD administered intravenously during HTV ventilation effectively reversed associated pulmonary oxidative stress and lung inflammation (P < 0.05); moreover, it preserved SP-A and SP-D expressions in the lung and increased serum nitric oxide (NO) level, enhancing vascular NO bioavailability. Cu/Zn SOD administered intravenously during HTV ventilation effectively reversed associated pulmonary oxidative stress and lung inflammation (P < 0.05); moreover, it preserved SP-A and SP-D expressions in the lung and increased serum nitric oxide (NO) level, enhancing vascular NO bioavailability. Intravenous administration of Cu/Zn SOD during HTV ventilation can prevent lung function impairment and lung injury via reducing pulmonary oxidative stress and lung inflammation, preserving pulmonary surfactant expression, and enhancing vascular NO bioavailability. In this study, HTV ventilation was shown to activate NF-κB and increase VCAM-1, MMP-9 and TNF-α protein expressions, whilst each factor plays a role in lung function impairment, and that was effectively attenuated by intravenous treatment of Cu/Zn SOD.	./cache/cord-002627-3jwu4pf2.txt	./txt/cord-002627-3jwu4pf2.txt