id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005476-q6o5239w	Griesenbach, U	Gene therapy for cystic fibrosis: an example for lung gene therapy	2004-09-29		.txt	text/plain	5903	290	44	Over the last decade, the gene therapy community has recognized that there is not even one vector that is good for all applications, but that the gene transfer agent (GTA) has to be carefully chosen depending on the cell type to be targeted, the number of treatments (one versus repeat administration) required, and the size and nature (secreted versus cellular product) of the gene to be delivered. In an attempt to increase the transfection efficiency of adenoviral vectors in vivo, Gregory et al 17 assessed the effects of sodium caprate (a tight junction opener) application to the luminal surface of AECs in mouse lung, with the rationale that CAR expression is higher on the basolateral surface of epithelial cells. RSV and PIV3 target human ciliated airway epithelial cells: efficient gene transfer vectors for cystic fibrosis lung disease	./cache/cord-005476-q6o5239w.txt	./txt/cord-005476-q6o5239w.txt