id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006289-2k8c22u8	Chu, Shi-Jye	Systemic Administration of FC-77 Dampens Ischemia–Reperfusion-Induced Acute Lung Injury in Rats	2013-06-27		.txt	text/plain	4296	246	48	Systemic administration of perfluorocarbons (PFCs) reportedly attenuates acute lung injury induced by acid aspiration and phorbol myristate acetate. TNF-α and cytokine-induced neutrophil chemoattractant-1 concentrations in perfusate samples and MDA concentration and MPO activities in lung tissues were also significantly increased. As shown in Fig. 6 , MDA concentration and MPO activity in lung tissues significantly increased in the IR group compared with those in the control group (P< 0.05). In this study, we demonstrated that pretreatment with FC-77 had beneficial effects on IR-induced increases in PAP, K f , lung weight gain, LW/BW ratio, W/D lung ratio, protein concentration in BALF, and TNF-α and CINC-1 concentrations in perfusate; and MDA concentration, MPO activity, and neutrophil infiltration in lung tissues. These results are in agreement with recent findings of decreased neutrophil accumulation, MPO activity, and oxidative damage in lung tissues by systemic PFC administration in a rat lung injury model [15] .	./cache/cord-006289-2k8c22u8.txt	./txt/cord-006289-2k8c22u8.txt