id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018086-klels5e3	Van der Kaaij, N.P.	Ischemia-reperfusion Injury of the Lung: Role of Surfactant	2005		.txt	text/plain	4315	231	40	Lung Ischemia-reperfusion Injury: Inactive ATP-dependent Membrane Pumps and Intracellular Calcium Accumulation Under normal conditions, the action of the Na + /K + -ATPase pump sets up a gradient of high extracellular Na + relative to intracellular levels, which in turn drives the Na + /Ca 2+exchanger, so that Ca 2+ is pumped out of the cell. Prostacyclin plays an important role in vascular function because it inhibits platelet adhe-Ischemia-reperfusion Injury of the Lung: Role of Surfactant 53 Fig. 3 . To study the complex pathophysiology of lung ischemia-reperfusion injury and to investigate surfactant treatment possibilities, an animal model is often used. Since surfactant is rate limiting for the transfer of proteins across the alveolo-capillary membrane and is either inactivated or lost due to the increased endothelial permeability after lung ischemia-reperfusion injury, a further influx of proteins is facilitated. Semik and colleagues showed that the decreased function of AT II cells after lung ischemia-reperfusion injury is prevented by surfactant treatment [42] .	./cache/cord-018086-klels5e3.txt	./txt/cord-018086-klels5e3.txt