id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-030130-n1x6gcn2	Hurtado, Daniel E.	Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation	2020-08-06		.txt	text/plain	5387	280	47	title: Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation BACKGROUND: Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. We hypothesize that regional deformation in lung injury progresses in time in spontaneous-breathing lungs, whereas it remains uniform in subjects under controlled MV. In this work, we studied the lung regional strain distribution, heterogeneity, and deformation progression in subjects spontaneously breathing and subjects on controlled low-V t MV in a murine lung-injury model. We found that a significant progression in regional volumetric strain and heterogeneity was observed after 3 h of spontaneous breathing in injured lungs. We identified a progression of regional deformation and heterogeneity in injured lungs under spontaneous breathing, but not in low V t MV subjects.	./cache/cord-030130-n1x6gcn2.txt	./txt/cord-030130-n1x6gcn2.txt