id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328266-bjs6ywlf	Gunasekaran, Muthukumar	Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection	2020-04-30		.txt	text/plain	4909	251	46	CONCLUSIONS Circulating exosomes isolated from lung transplant recipients diagnosed with respiratory viral infections contained lung self-antigens, viral antigens, and 20S proteasome and elicited immune responses to lung self-antigens that resulted in development of chronic lung allograft dysfunction in immunized mice. Previously reported risk factors for CLAD include acute rejection, 4−6 cytomegalovirus (CMV) pneumonitis, 7 antibodies (Abs) to donor human leukocyte antigen (HLA), 8, 9 Abs to non-HLA lung-associated self-antigens (SAgs), 10−12 primary graft dysfunction, 13 and respiratory viral infections (RVIs). In this study, we tested the hypothesis that RVI-induced allograft injury may induce circulating exosomes that contain donor HLA, SAgs, and viral antigens, which may activate donor-specific immune responses and increase the risk of CLAD. Col-V, collagen-V; Ka1T, K-alpha-1 tubulin; LTxR, lung transplant recipient; OD, optical density; RVI, respiratory viral infection; SAg, self-antigen. Exosomes isolated from serum samples of patients with RVI and from stable LTxRs were used to detect the presence of lung-associated SAgs and viral antigens using immunoblot.	./cache/cord-328266-bjs6ywlf.txt	./txt/cord-328266-bjs6ywlf.txt