id sid tid token lemma pos cord-342150-dadc8whz 1 1 key key JJ cord-342150-dadc8whz 1 2 : : : cord-342150-dadc8whz 1 3 cord-342150-dadc8whz cord-342150-dadc8whz NN cord-342150-dadc8whz 1 4 authors author NNS cord-342150-dadc8whz 1 5 : : : cord-342150-dadc8whz 1 6 Lindahl Lindahl NNP cord-342150-dadc8whz 1 7 , , , cord-342150-dadc8whz 1 8 Sten Sten NNP cord-342150-dadc8whz 1 9 G. G. NNP cord-342150-dadc8whz 1 10 E. E. NNP cord-342150-dadc8whz 1 11 title title NN cord-342150-dadc8whz 1 12 : : : cord-342150-dadc8whz 1 13 Using use VBG cord-342150-dadc8whz 1 14 the the DT cord-342150-dadc8whz 1 15 prone prone JJ cord-342150-dadc8whz 1 16 position position NN cord-342150-dadc8whz 1 17 could could MD cord-342150-dadc8whz 1 18 help help VB cord-342150-dadc8whz 1 19 to to TO cord-342150-dadc8whz 1 20 combat combat VB cord-342150-dadc8whz 1 21 the the DT cord-342150-dadc8whz 1 22 development development NN cord-342150-dadc8whz 1 23 of of IN cord-342150-dadc8whz 1 24 fast fast JJ cord-342150-dadc8whz 1 25 hypoxia hypoxia NN cord-342150-dadc8whz 1 26 in in IN cord-342150-dadc8whz 1 27 some some DT cord-342150-dadc8whz 1 28 patients patient NNS cord-342150-dadc8whz 1 29 with with IN cord-342150-dadc8whz 1 30 COVID‐19 COVID‐19 NNP cord-342150-dadc8whz 1 31 date date NN cord-342150-dadc8whz 1 32 : : : cord-342150-dadc8whz 1 33 2020 2020 CD cord-342150-dadc8whz 1 34 - - HYPH cord-342150-dadc8whz 1 35 06 06 CD cord-342150-dadc8whz 1 36 - - SYM cord-342150-dadc8whz 1 37 17 17 CD cord-342150-dadc8whz 1 38 journal journal NN cord-342150-dadc8whz 1 39 : : : cord-342150-dadc8whz 2 1 Acta Acta NNP cord-342150-dadc8whz 2 2 Paediatr Paediatr NNP cord-342150-dadc8whz 2 3 DOI DOI NNP cord-342150-dadc8whz 2 4 : : : cord-342150-dadc8whz 3 1 10.1111 10.1111 CD cord-342150-dadc8whz 3 2 / / SYM cord-342150-dadc8whz 3 3 apa.15382 apa.15382 NNP cord-342150-dadc8whz 4 1 sha sha NNP cord-342150-dadc8whz 4 2 : : : cord-342150-dadc8whz 4 3 dcd6615504664c8b7f2cc7213a02ca0a63d5b418 dcd6615504664c8b7f2cc7213a02ca0a63d5b418 NNP cord-342150-dadc8whz 4 4 doc_id doc_id CD cord-342150-dadc8whz 4 5 : : : cord-342150-dadc8whz 4 6 342150 342150 CD cord-342150-dadc8whz 4 7 cord_uid cord_uid NNS cord-342150-dadc8whz 4 8 : : : cord-342150-dadc8whz 4 9 dadc8whz dadc8whz NN cord-342150-dadc8whz 5 1 The the DT cord-342150-dadc8whz 5 2 world world NN cord-342150-dadc8whz 5 3 is be VBZ cord-342150-dadc8whz 5 4 facing face VBG cord-342150-dadc8whz 5 5 an an DT cord-342150-dadc8whz 5 6 explosive explosive JJ cord-342150-dadc8whz 5 7 COVID‐19 covid‐19 NN cord-342150-dadc8whz 5 8 pandemic pandemic NN cord-342150-dadc8whz 5 9 . . . cord-342150-dadc8whz 6 1 Some some DT cord-342150-dadc8whz 6 2 cases case NNS cord-342150-dadc8whz 6 3 rapidly rapidly RB cord-342150-dadc8whz 6 4 develop develop VBP cord-342150-dadc8whz 6 5 deteriorating deteriorate VBG cord-342150-dadc8whz 6 6 lung lung NN cord-342150-dadc8whz 6 7 function function NN cord-342150-dadc8whz 6 8 , , , cord-342150-dadc8whz 6 9 which which WDT cord-342150-dadc8whz 6 10 causes cause VBZ cord-342150-dadc8whz 6 11 deep deep JJ cord-342150-dadc8whz 6 12 hypoxaemia hypoxaemia NN cord-342150-dadc8whz 6 13 and and CC cord-342150-dadc8whz 6 14 requires require VBZ cord-342150-dadc8whz 6 15 urgent urgent JJ cord-342150-dadc8whz 6 16 treatment treatment NN cord-342150-dadc8whz 6 17 . . . cord-342150-dadc8whz 7 1 Many many JJ cord-342150-dadc8whz 7 2 centres centre NNS cord-342150-dadc8whz 7 3 have have VBP cord-342150-dadc8whz 7 4 started start VBN cord-342150-dadc8whz 7 5 treating treat VBG cord-342150-dadc8whz 7 6 patients patient NNS cord-342150-dadc8whz 7 7 in in IN cord-342150-dadc8whz 7 8 the the DT cord-342150-dadc8whz 7 9 prone prone JJ cord-342150-dadc8whz 7 10 position position NN cord-342150-dadc8whz 7 11 , , , cord-342150-dadc8whz 7 12 and and CC cord-342150-dadc8whz 7 13 oxygenation oxygenation NN cord-342150-dadc8whz 7 14 has have VBZ cord-342150-dadc8whz 7 15 improved improve VBN cord-342150-dadc8whz 7 16 considerably considerably RB cord-342150-dadc8whz 7 17 in in IN cord-342150-dadc8whz 7 18 some some DT cord-342150-dadc8whz 7 19 cases case NNS cord-342150-dadc8whz 7 20 . . . cord-342150-dadc8whz 8 1 Questions question NNS cord-342150-dadc8whz 8 2 have have VBP cord-342150-dadc8whz 8 3 been be VBN cord-342150-dadc8whz 8 4 raised raise VBN cord-342150-dadc8whz 8 5 regarding regard VBG cord-342150-dadc8whz 8 6 the the DT cord-342150-dadc8whz 8 7 mechanisms mechanism NNS cord-342150-dadc8whz 8 8 behind behind IN cord-342150-dadc8whz 8 9 this this DT cord-342150-dadc8whz 8 10 . . . cord-342150-dadc8whz 9 1 The the DT cord-342150-dadc8whz 9 2 mini mini JJ cord-342150-dadc8whz 9 3 review review NN cord-342150-dadc8whz 9 4 provides provide VBZ cord-342150-dadc8whz 9 5 some some DT cord-342150-dadc8whz 9 6 insights insight NNS cord-342150-dadc8whz 9 7 into into IN cord-342150-dadc8whz 9 8 the the DT cord-342150-dadc8whz 9 9 role role NN cord-342150-dadc8whz 9 10 of of IN cord-342150-dadc8whz 9 11 supine supine JJ cord-342150-dadc8whz 9 12 and and CC cord-342150-dadc8whz 9 13 prone prone JJ cord-342150-dadc8whz 9 14 body body NN cord-342150-dadc8whz 9 15 positions position NNS cord-342150-dadc8whz 9 16 and and CC cord-342150-dadc8whz 9 17 summarises summarise VBZ cord-342150-dadc8whz 9 18 the the DT cord-342150-dadc8whz 9 19 latest late JJS cord-342150-dadc8whz 9 20 understanding understanding NN cord-342150-dadc8whz 9 21 of of IN cord-342150-dadc8whz 9 22 the the DT cord-342150-dadc8whz 9 23 responsible responsible JJ cord-342150-dadc8whz 9 24 mechanisms mechanism NNS cord-342150-dadc8whz 9 25 . . . cord-342150-dadc8whz 10 1 The the DT cord-342150-dadc8whz 10 2 scope scope NN cord-342150-dadc8whz 10 3 for for IN cord-342150-dadc8whz 10 4 discussion discussion NN cord-342150-dadc8whz 10 5 is be VBZ cord-342150-dadc8whz 10 6 outside outside IN cord-342150-dadc8whz 10 7 the the DT cord-342150-dadc8whz 10 8 neonatal neonatal JJ cord-342150-dadc8whz 10 9 period period NN cord-342150-dadc8whz 10 10 and and CC cord-342150-dadc8whz 10 11 entirely entirely RB cord-342150-dadc8whz 10 12 based base VBN cord-342150-dadc8whz 10 13 on on IN cord-342150-dadc8whz 10 14 experimental experimental JJ cord-342150-dadc8whz 10 15 and and CC cord-342150-dadc8whz 10 16 clinical clinical JJ cord-342150-dadc8whz 10 17 experiences experience NNS cord-342150-dadc8whz 10 18 related relate VBN cord-342150-dadc8whz 10 19 to to IN cord-342150-dadc8whz 10 20 adults adult NNS cord-342150-dadc8whz 10 21 . . . cord-342150-dadc8whz 11 1 The the DT cord-342150-dadc8whz 11 2 human human JJ cord-342150-dadc8whz 11 3 respiratory respiratory JJ cord-342150-dadc8whz 11 4 system system NN cord-342150-dadc8whz 11 5 is be VBZ cord-342150-dadc8whz 11 6 a a DT cord-342150-dadc8whz 11 7 complex complex JJ cord-342150-dadc8whz 11 8 interplay interplay NN cord-342150-dadc8whz 11 9 of of IN cord-342150-dadc8whz 11 10 many many JJ cord-342150-dadc8whz 11 11 different different JJ cord-342150-dadc8whz 11 12 variables variable NNS cord-342150-dadc8whz 11 13 . . . cord-342150-dadc8whz 12 1 Therefore therefore RB cord-342150-dadc8whz 12 2 , , , cord-342150-dadc8whz 12 3 this this DT cord-342150-dadc8whz 12 4 mini mini NN cord-342150-dadc8whz 12 5 review review NN cord-342150-dadc8whz 12 6 has have VBZ cord-342150-dadc8whz 12 7 prioritised prioritise VBN cord-342150-dadc8whz 12 8 previous previous JJ cord-342150-dadc8whz 12 9 and and CC cord-342150-dadc8whz 12 10 ongoing ongoing JJ cord-342150-dadc8whz 12 11 research research NN cord-342150-dadc8whz 12 12 to to TO cord-342150-dadc8whz 12 13 find find VB cord-342150-dadc8whz 12 14 explanations explanation NNS cord-342150-dadc8whz 12 15 based base VBN cord-342150-dadc8whz 12 16 on on IN cord-342150-dadc8whz 12 17 three three CD cord-342150-dadc8whz 12 18 scientific scientific JJ cord-342150-dadc8whz 12 19 areas area NNS cord-342150-dadc8whz 12 20 : : : cord-342150-dadc8whz 12 21 gravity gravity NN cord-342150-dadc8whz 12 22 , , , cord-342150-dadc8whz 12 23 lung lung NN cord-342150-dadc8whz 12 24 structure structure NN cord-342150-dadc8whz 12 25 and and CC cord-342150-dadc8whz 12 26 fractal fractal JJ cord-342150-dadc8whz 12 27 geometry geometry NN cord-342150-dadc8whz 12 28 and and CC cord-342150-dadc8whz 12 29 vascular vascular JJ cord-342150-dadc8whz 12 30 regulation regulation NN cord-342150-dadc8whz 12 31 . . . cord-342150-dadc8whz 13 1 It -PRON- PRP cord-342150-dadc8whz 13 2 concludes conclude VBZ cord-342150-dadc8whz 13 3 that that IN cord-342150-dadc8whz 13 4 gravity gravity NN cord-342150-dadc8whz 13 5 is be VBZ cord-342150-dadc8whz 13 6 one one CD cord-342150-dadc8whz 13 7 of of IN cord-342150-dadc8whz 13 8 the the DT cord-342150-dadc8whz 13 9 variables variable NNS cord-342150-dadc8whz 13 10 responsible responsible JJ cord-342150-dadc8whz 13 11 for for IN cord-342150-dadc8whz 13 12 ventilation ventilation NN cord-342150-dadc8whz 13 13 / / SYM cord-342150-dadc8whz 13 14 perfusion perfusion NN cord-342150-dadc8whz 13 15 matching matching NN cord-342150-dadc8whz 13 16 but but CC cord-342150-dadc8whz 13 17 in in IN cord-342150-dadc8whz 13 18 concert concert NN cord-342150-dadc8whz 13 19 with with IN cord-342150-dadc8whz 13 20 lung lung NN cord-342150-dadc8whz 13 21 structure structure NN cord-342150-dadc8whz 13 22 and and CC cord-342150-dadc8whz 13 23 fractal fractal JJ cord-342150-dadc8whz 13 24 geometry geometry NN cord-342150-dadc8whz 13 25 , , , cord-342150-dadc8whz 13 26 ventilation ventilation NN cord-342150-dadc8whz 13 27 and and CC cord-342150-dadc8whz 13 28 regulation regulation NN cord-342150-dadc8whz 13 29 of of IN cord-342150-dadc8whz 13 30 lung lung NN cord-342150-dadc8whz 13 31 vascular vascular JJ cord-342150-dadc8whz 13 32 tone tone NN cord-342150-dadc8whz 13 33 . . . cord-342150-dadc8whz 14 1 Since since IN cord-342150-dadc8whz 14 2 ventilation ventilation NN cord-342150-dadc8whz 14 3 distribution distribution NN cord-342150-dadc8whz 14 4 does do VBZ cord-342150-dadc8whz 14 5 not not RB cord-342150-dadc8whz 14 6 change change VB cord-342150-dadc8whz 14 7 between between IN cord-342150-dadc8whz 14 8 supine supine JJ cord-342150-dadc8whz 14 9 and and CC cord-342150-dadc8whz 14 10 prone prone JJ cord-342150-dadc8whz 14 11 positions position NNS cord-342150-dadc8whz 14 12 , , , cord-342150-dadc8whz 14 13 the the DT cord-342150-dadc8whz 14 14 higher high JJR cord-342150-dadc8whz 14 15 expression expression NN cord-342150-dadc8whz 14 16 of of IN cord-342150-dadc8whz 14 17 nitric nitric JJ cord-342150-dadc8whz 14 18 oxide oxide NN cord-342150-dadc8whz 14 19 in in IN cord-342150-dadc8whz 14 20 dorsal dorsal JJ cord-342150-dadc8whz 14 21 lung lung NN cord-342150-dadc8whz 14 22 vessels vessel NNS cord-342150-dadc8whz 14 23 than than IN cord-342150-dadc8whz 14 24 in in IN cord-342150-dadc8whz 14 25 ventral ventral JJ cord-342150-dadc8whz 14 26 vessels vessel NNS cord-342150-dadc8whz 14 27 is be VBZ cord-342150-dadc8whz 14 28 likely likely JJ cord-342150-dadc8whz 14 29 to to TO cord-342150-dadc8whz 14 30 be be VB cord-342150-dadc8whz 14 31 the the DT cord-342150-dadc8whz 14 32 most most RBS cord-342150-dadc8whz 14 33 important important JJ cord-342150-dadc8whz 14 34 mechanism mechanism NN cord-342150-dadc8whz 14 35 behind behind IN cord-342150-dadc8whz 14 36 enhanced enhanced JJ cord-342150-dadc8whz 14 37 oxygenation oxygenation NN cord-342150-dadc8whz 14 38 in in IN cord-342150-dadc8whz 14 39 the the DT cord-342150-dadc8whz 14 40 prone prone JJ cord-342150-dadc8whz 14 41 position position NN cord-342150-dadc8whz 14 42 . . . cord-342150-dadc8whz 15 1 Hence hence RB cord-342150-dadc8whz 15 2 , , , cord-342150-dadc8whz 15 3 the the DT cord-342150-dadc8whz 15 4 prone prone JJ cord-342150-dadc8whz 15 5 position position NN cord-342150-dadc8whz 15 6 in in IN cord-342150-dadc8whz 15 7 infants infant NNS cord-342150-dadc8whz 15 8 younger young JJR cord-342150-dadc8whz 15 9 than than IN cord-342150-dadc8whz 15 10 6 6 CD cord-342150-dadc8whz 15 11 months month NNS cord-342150-dadc8whz 15 12 is be VBZ cord-342150-dadc8whz 15 13 not not RB cord-342150-dadc8whz 15 14 recommended recommend VBN cord-342150-dadc8whz 15 15 . . . cord-342150-dadc8whz 16 1 However however RB cord-342150-dadc8whz 16 2 , , , cord-342150-dadc8whz 16 3 it -PRON- PRP cord-342150-dadc8whz 16 4 may may MD cord-342150-dadc8whz 16 5 be be VB cord-342150-dadc8whz 16 6 discussed discuss VBN cord-342150-dadc8whz 16 7 with with IN cord-342150-dadc8whz 16 8 regard regard NN cord-342150-dadc8whz 16 9 to to IN cord-342150-dadc8whz 16 10 toddlers toddler NNS cord-342150-dadc8whz 16 11 , , , cord-342150-dadc8whz 16 12 pre pre JJ cord-342150-dadc8whz 16 13 - - JJ cord-342150-dadc8whz 16 14 school school JJ cord-342150-dadc8whz 16 15 and and CC cord-342150-dadc8whz 16 16 school school NN cord-342150-dadc8whz 16 17 children child NNS cord-342150-dadc8whz 16 18 who who WP cord-342150-dadc8whz 16 19 suffer suffer VBP cord-342150-dadc8whz 16 20 from from IN cord-342150-dadc8whz 16 21 acute acute JJ cord-342150-dadc8whz 16 22 lung lung NN cord-342150-dadc8whz 16 23 insufficiency insufficiency NN cord-342150-dadc8whz 16 24 with with IN cord-342150-dadc8whz 16 25 deep deep JJ cord-342150-dadc8whz 16 26 hypoxaemia hypoxaemia NN cord-342150-dadc8whz 16 27 to to IN cord-342150-dadc8whz 16 28 such such PDT cord-342150-dadc8whz 16 29 an an DT cord-342150-dadc8whz 16 30 extent extent NN cord-342150-dadc8whz 16 31 that that IN cord-342150-dadc8whz 16 32 it -PRON- PRP cord-342150-dadc8whz 16 33 threatens threaten VBZ cord-342150-dadc8whz 16 34 their -PRON- PRP$ cord-342150-dadc8whz 16 35 life life NN cord-342150-dadc8whz 16 36 . . . cord-342150-dadc8whz 17 1 But but CC cord-342150-dadc8whz 17 2 these these DT cord-342150-dadc8whz 17 3 age age NN cord-342150-dadc8whz 17 4 groups group NNS cord-342150-dadc8whz 17 5 are be VBP cord-342150-dadc8whz 17 6 not not RB cord-342150-dadc8whz 17 7 so so RB cord-342150-dadc8whz 17 8 well well RB cord-342150-dadc8whz 17 9 studied study VBN cord-342150-dadc8whz 17 10 . . . cord-342150-dadc8whz 18 1 The the DT cord-342150-dadc8whz 18 2 subject subject NN cord-342150-dadc8whz 18 3 is be VBZ cord-342150-dadc8whz 18 4 highly highly RB cord-342150-dadc8whz 18 5 interesting interesting JJ cord-342150-dadc8whz 18 6 , , , cord-342150-dadc8whz 18 7 and and CC cord-342150-dadc8whz 18 8 it -PRON- PRP cord-342150-dadc8whz 18 9 will will MD cord-342150-dadc8whz 18 10 be be VB cord-342150-dadc8whz 18 11 a a DT cord-342150-dadc8whz 18 12 challenge challenge NN cord-342150-dadc8whz 18 13 in in IN cord-342150-dadc8whz 18 14 the the DT cord-342150-dadc8whz 18 15 future future NN cord-342150-dadc8whz 18 16 to to TO cord-342150-dadc8whz 18 17 design design NN cord-342150-dadc8whz 18 18 investigations investigation NNS cord-342150-dadc8whz 18 19 that that WDT cord-342150-dadc8whz 18 20 are be VBP cord-342150-dadc8whz 18 21 able able JJ cord-342150-dadc8whz 18 22 to to TO cord-342150-dadc8whz 18 23 evaluate evaluate VB cord-342150-dadc8whz 18 24 prone prone JJ cord-342150-dadc8whz 18 25 and and CC cord-342150-dadc8whz 18 26 supine supine JJ cord-342150-dadc8whz 18 27 positions position NNS cord-342150-dadc8whz 18 28 in in IN cord-342150-dadc8whz 18 29 a a DT cord-342150-dadc8whz 18 30 developing develop VBG cord-342150-dadc8whz 18 31 respiratory respiratory JJ cord-342150-dadc8whz 18 32 system system NN cord-342150-dadc8whz 18 33 . . . cord-342150-dadc8whz 19 1 This this DT cord-342150-dadc8whz 19 2 paper paper NN cord-342150-dadc8whz 19 3 reviews review VBZ cord-342150-dadc8whz 19 4 the the DT cord-342150-dadc8whz 19 5 use use NN cord-342150-dadc8whz 19 6 of of IN cord-342150-dadc8whz 19 7 supine supine JJ cord-342150-dadc8whz 19 8 and and CC cord-342150-dadc8whz 19 9 prone prone JJ cord-342150-dadc8whz 19 10 positions position NNS cord-342150-dadc8whz 19 11 in in IN cord-342150-dadc8whz 19 12 adult adult NN cord-342150-dadc8whz 19 13 patients patient NNS cord-342150-dadc8whz 19 14 with with IN cord-342150-dadc8whz 19 15 severe severe JJ cord-342150-dadc8whz 19 16 respiratory respiratory JJ cord-342150-dadc8whz 19 17 insufficiency insufficiency NN cord-342150-dadc8whz 19 18 . . . cord-342150-dadc8whz 20 1 It -PRON- PRP cord-342150-dadc8whz 20 2 aims aim VBZ cord-342150-dadc8whz 20 3 to to TO cord-342150-dadc8whz 20 4 reach reach VB cord-342150-dadc8whz 20 5 a a DT cord-342150-dadc8whz 20 6 conclusion conclusion NN cord-342150-dadc8whz 20 7 about about IN cord-342150-dadc8whz 20 8 the the DT cord-342150-dadc8whz 20 9 mechanisms mechanism NNS cord-342150-dadc8whz 20 10 that that WDT cord-342150-dadc8whz 20 11 explain explain VBP cord-342150-dadc8whz 20 12 the the DT cord-342150-dadc8whz 20 13 sometimes sometimes RB cord-342150-dadc8whz 20 14 dramatic dramatic JJ cord-342150-dadc8whz 20 15 improvements improvement NNS cord-342150-dadc8whz 20 16 in in IN cord-342150-dadc8whz 20 17 oxygenation oxygenation NN cord-342150-dadc8whz 20 18 when when WRB cord-342150-dadc8whz 20 19 these these DT cord-342150-dadc8whz 20 20 patients patient NNS cord-342150-dadc8whz 20 21 are be VBP cord-342150-dadc8whz 20 22 turned turn VBN cord-342150-dadc8whz 20 23 prone prone JJ cord-342150-dadc8whz 20 24 . . . cord-342150-dadc8whz 21 1 But but CC cord-342150-dadc8whz 21 2 it -PRON- PRP cord-342150-dadc8whz 21 3 has have VBZ cord-342150-dadc8whz 21 4 been be VBN cord-342150-dadc8whz 21 5 difficult difficult JJ cord-342150-dadc8whz 21 6 to to TO cord-342150-dadc8whz 21 7 demonstrate demonstrate VB cord-342150-dadc8whz 21 8 that that IN cord-342150-dadc8whz 21 9 the the DT cord-342150-dadc8whz 21 10 prone prone JJ cord-342150-dadc8whz 21 11 position position NN cord-342150-dadc8whz 21 12 used use VBN cord-342150-dadc8whz 21 13 for for IN cord-342150-dadc8whz 21 14 these these DT cord-342150-dadc8whz 21 15 sick sick JJ cord-342150-dadc8whz 21 16 patients patient NNS cord-342150-dadc8whz 21 17 also also RB cord-342150-dadc8whz 21 18 improves improve VBZ cord-342150-dadc8whz 21 19 mortality mortality NN cord-342150-dadc8whz 21 20 rates rate NNS cord-342150-dadc8whz 21 21 . . . cord-342150-dadc8whz 22 1 Such such JJ cord-342150-dadc8whz 22 2 studies study NNS cord-342150-dadc8whz 22 3 are be VBP cord-342150-dadc8whz 22 4 difficult difficult JJ cord-342150-dadc8whz 22 5 to to TO cord-342150-dadc8whz 22 6 perform perform VB cord-342150-dadc8whz 22 7 and and CC cord-342150-dadc8whz 22 8 interpret interpret VB cord-342150-dadc8whz 22 9 , , , cord-342150-dadc8whz 22 10 as as IN cord-342150-dadc8whz 22 11 the the DT cord-342150-dadc8whz 22 12 nature nature NN cord-342150-dadc8whz 22 13 of of IN cord-342150-dadc8whz 22 14 the the DT cord-342150-dadc8whz 22 15 disease disease NN cord-342150-dadc8whz 22 16 and and CC cord-342150-dadc8whz 22 17 the the DT cord-342150-dadc8whz 22 18 extremely extremely RB cord-342150-dadc8whz 22 19 complex complex JJ cord-342150-dadc8whz 22 20 intensive intensive JJ cord-342150-dadc8whz 22 21 care care NN cord-342150-dadc8whz 22 22 they -PRON- PRP cord-342150-dadc8whz 22 23 receive receive VBP cord-342150-dadc8whz 22 24 are be VBP cord-342150-dadc8whz 22 25 hard hard JJ cord-342150-dadc8whz 22 26 to to TO cord-342150-dadc8whz 22 27 control control VB cord-342150-dadc8whz 22 28 . . . cord-342150-dadc8whz 23 1 This this DT cord-342150-dadc8whz 23 2 makes make VBZ cord-342150-dadc8whz 23 3 it -PRON- PRP cord-342150-dadc8whz 23 4 hard hard JJ cord-342150-dadc8whz 23 5 to to TO cord-342150-dadc8whz 23 6 evaluate evaluate VB cord-342150-dadc8whz 23 7 comparable comparable JJ cord-342150-dadc8whz 23 8 patient patient JJ cord-342150-dadc8whz 23 9 groups group NNS cord-342150-dadc8whz 23 10 and and CC cord-342150-dadc8whz 23 11 collect collect VB cord-342150-dadc8whz 23 12 reliable reliable JJ cord-342150-dadc8whz 23 13 outcome outcome NN cord-342150-dadc8whz 23 14 data datum NNS cord-342150-dadc8whz 23 15 . . . cord-342150-dadc8whz 24 1 This this DT cord-342150-dadc8whz 24 2 point point NN cord-342150-dadc8whz 24 3 was be VBD cord-342150-dadc8whz 24 4 well well RB cord-342150-dadc8whz 24 5 made make VBN cord-342150-dadc8whz 24 6 in in IN cord-342150-dadc8whz 24 7 a a DT cord-342150-dadc8whz 24 8 2019 2019 CD cord-342150-dadc8whz 24 9 paper paper NN cord-342150-dadc8whz 24 10 by by IN cord-342150-dadc8whz 24 11 Gattinoni Gattinoni NNP cord-342150-dadc8whz 24 12 et et NNP cord-342150-dadc8whz 24 13 al al NNP cord-342150-dadc8whz 24 14 which which WDT cord-342150-dadc8whz 24 15 also also RB cord-342150-dadc8whz 24 16 highlighted highlight VBD cord-342150-dadc8whz 24 17 the the DT cord-342150-dadc8whz 24 18 impact impact NN cord-342150-dadc8whz 24 19 of of IN cord-342150-dadc8whz 24 20 protective protective JJ cord-342150-dadc8whz 24 21 ventilator ventilator NN cord-342150-dadc8whz 24 22 settings setting NNS cord-342150-dadc8whz 24 23 to to TO cord-342150-dadc8whz 24 24 avoid avoid VB cord-342150-dadc8whz 24 25 ventilator ventilator NN cord-342150-dadc8whz 24 26 - - HYPH cord-342150-dadc8whz 24 27 induced induce VBN cord-342150-dadc8whz 24 28 lung lung NN cord-342150-dadc8whz 24 29 injuries injury NNS cord-342150-dadc8whz 24 30 . . . cord-342150-dadc8whz 25 1 1 1 LS cord-342150-dadc8whz 26 1 Guérin Guérin NNP cord-342150-dadc8whz 26 2 et et NNP cord-342150-dadc8whz 26 3 al al NNP cord-342150-dadc8whz 26 4 examined examine VBD cord-342150-dadc8whz 26 5 a a DT cord-342150-dadc8whz 26 6 well well RB cord-342150-dadc8whz 26 7 - - HYPH cord-342150-dadc8whz 26 8 controlled control VBN cord-342150-dadc8whz 26 9 and and CC cord-342150-dadc8whz 26 10 carefully carefully RB cord-342150-dadc8whz 26 11 selected select VBN cord-342150-dadc8whz 26 12 patient patient JJ cord-342150-dadc8whz 26 13 population population NN cord-342150-dadc8whz 26 14 that that WDT cord-342150-dadc8whz 26 15 received receive VBD cord-342150-dadc8whz 26 16 intensive intensive JJ cord-342150-dadc8whz 26 17 care care NN cord-342150-dadc8whz 26 18 and and CC cord-342150-dadc8whz 26 19 assessed assess VBD cord-342150-dadc8whz 26 20 the the DT cord-342150-dadc8whz 26 21 mortality mortality NN cord-342150-dadc8whz 26 22 rates rate NNS cord-342150-dadc8whz 26 23 related relate VBN cord-342150-dadc8whz 26 24 to to IN cord-342150-dadc8whz 26 25 supine supine JJ cord-342150-dadc8whz 26 26 and and CC cord-342150-dadc8whz 26 27 prone prone JJ cord-342150-dadc8whz 26 28 positions position NNS cord-342150-dadc8whz 26 29 . . . cord-342150-dadc8whz 27 1 The the DT cord-342150-dadc8whz 27 2 authors author NNS cord-342150-dadc8whz 27 3 concluded conclude VBD cord-342150-dadc8whz 27 4 that that IN cord-342150-dadc8whz 27 5 mortality mortality NN cord-342150-dadc8whz 27 6 was be VBD cord-342150-dadc8whz 27 7 lower low JJR cord-342150-dadc8whz 27 8 in in IN cord-342150-dadc8whz 27 9 the the DT cord-342150-dadc8whz 27 10 group group NN cord-342150-dadc8whz 27 11 treated treat VBD cord-342150-dadc8whz 27 12 prone prone JJ cord-342150-dadc8whz 27 13 . . . cord-342150-dadc8whz 28 1 2 2 LS cord-342150-dadc8whz 29 1 The the DT cord-342150-dadc8whz 29 2 world world NN cord-342150-dadc8whz 29 3 is be VBZ cord-342150-dadc8whz 29 4 currently currently RB cord-342150-dadc8whz 29 5 experiencing experience VBG cord-342150-dadc8whz 29 6 an an DT cord-342150-dadc8whz 29 7 explosive explosive JJ cord-342150-dadc8whz 29 8 pandemic pandemic NN cord-342150-dadc8whz 29 9 caused cause VBN cord-342150-dadc8whz 29 10 by by IN cord-342150-dadc8whz 29 11 a a DT cord-342150-dadc8whz 29 12 new new JJ cord-342150-dadc8whz 29 13 coronavirus coronavirus NN cord-342150-dadc8whz 29 14 , , , cord-342150-dadc8whz 29 15 with with IN cord-342150-dadc8whz 29 16 a a DT cord-342150-dadc8whz 29 17 clinical clinical JJ cord-342150-dadc8whz 29 18 presentation presentation NN cord-342150-dadc8whz 29 19 of of IN cord-342150-dadc8whz 29 20 a a DT cord-342150-dadc8whz 29 21 somewhat somewhat RB cord-342150-dadc8whz 29 22 different different JJ cord-342150-dadc8whz 29 23 kind kind NN cord-342150-dadc8whz 29 24 . . . cord-342150-dadc8whz 30 1 In in IN cord-342150-dadc8whz 30 2 some some DT cord-342150-dadc8whz 30 3 cases case NNS cord-342150-dadc8whz 30 4 , , , cord-342150-dadc8whz 30 5 patients patient NNS cord-342150-dadc8whz 30 6 experience experience VBP cord-342150-dadc8whz 30 7 rapidly rapidly RB cord-342150-dadc8whz 30 8 deteriorating deteriorate VBG cord-342150-dadc8whz 30 9 The the DT cord-342150-dadc8whz 30 10 function function NN cord-342150-dadc8whz 30 11 of of IN cord-342150-dadc8whz 30 12 the the DT cord-342150-dadc8whz 30 13 human human JJ cord-342150-dadc8whz 30 14 respiratory respiratory JJ cord-342150-dadc8whz 30 15 system system NN cord-342150-dadc8whz 31 1 is be VBZ cord-342150-dadc8whz 31 2 a a DT cord-342150-dadc8whz 31 3 complex complex JJ cord-342150-dadc8whz 31 4 interplay interplay NN cord-342150-dadc8whz 31 5 of of IN cord-342150-dadc8whz 31 6 different different JJ cord-342150-dadc8whz 31 7 variables variable NNS cord-342150-dadc8whz 31 8 , , , cord-342150-dadc8whz 31 9 such such JJ cord-342150-dadc8whz 31 10 as as IN cord-342150-dadc8whz 31 11 the the DT cord-342150-dadc8whz 31 12 rib rib NN cord-342150-dadc8whz 31 13 cage cage NN cord-342150-dadc8whz 31 14 , , , cord-342150-dadc8whz 31 15 the the DT cord-342150-dadc8whz 31 16 diaphragm diaphragm NN cord-342150-dadc8whz 31 17 , , , cord-342150-dadc8whz 31 18 abdominal abdominal JJ cord-342150-dadc8whz 31 19 distension distension NN cord-342150-dadc8whz 31 20 , , , cord-342150-dadc8whz 31 21 pleural pleural JJ cord-342150-dadc8whz 31 22 pressure pressure NN cord-342150-dadc8whz 31 23 , , , cord-342150-dadc8whz 31 24 body body NN cord-342150-dadc8whz 31 25 fluids fluid NNS cord-342150-dadc8whz 31 26 , , , cord-342150-dadc8whz 31 27 heart heart NN cord-342150-dadc8whz 31 28 function function NN cord-342150-dadc8whz 31 29 , , , cord-342150-dadc8whz 31 30 pulmonary pulmonary JJ cord-342150-dadc8whz 31 31 and and CC cord-342150-dadc8whz 31 32 systemic systemic JJ cord-342150-dadc8whz 31 33 circulation circulation NN cord-342150-dadc8whz 31 34 , , , cord-342150-dadc8whz 31 35 lung lung NN cord-342150-dadc8whz 31 36 parenchyma parenchyma NN cord-342150-dadc8whz 31 37 , , , cord-342150-dadc8whz 31 38 the the DT cord-342150-dadc8whz 31 39 tracheobronchial tracheobronchial JJ cord-342150-dadc8whz 31 40 tree tree NN cord-342150-dadc8whz 31 41 , , , cord-342150-dadc8whz 31 42 alveoli alveolus NNS cord-342150-dadc8whz 31 43 and and CC cord-342150-dadc8whz 31 44 central central JJ cord-342150-dadc8whz 31 45 and and CC cord-342150-dadc8whz 31 46 peripheral peripheral JJ cord-342150-dadc8whz 31 47 innervation innervation NN cord-342150-dadc8whz 31 48 . . . cord-342150-dadc8whz 32 1 All all DT cord-342150-dadc8whz 32 2 of of IN cord-342150-dadc8whz 32 3 these these DT cord-342150-dadc8whz 32 4 act act NN cord-342150-dadc8whz 32 5 in in IN cord-342150-dadc8whz 32 6 concert concert NN cord-342150-dadc8whz 32 7 to to TO cord-342150-dadc8whz 32 8 achieve achieve VB cord-342150-dadc8whz 32 9 adequate adequate JJ cord-342150-dadc8whz 32 10 gas gas NN cord-342150-dadc8whz 32 11 exchange exchange NN cord-342150-dadc8whz 32 12 for for IN cord-342150-dadc8whz 32 13 the the DT cord-342150-dadc8whz 32 14 maintenance maintenance NN cord-342150-dadc8whz 32 15 of of IN cord-342150-dadc8whz 32 16 life life NN cord-342150-dadc8whz 32 17 . . . cord-342150-dadc8whz 33 1 Each each DT cord-342150-dadc8whz 33 2 of of IN cord-342150-dadc8whz 33 3 them -PRON- PRP cord-342150-dadc8whz 33 4 is be VBZ cord-342150-dadc8whz 33 5 a a DT cord-342150-dadc8whz 33 6 theoretical theoretical JJ cord-342150-dadc8whz 33 7 area area NN cord-342150-dadc8whz 33 8 in in IN cord-342150-dadc8whz 33 9 its -PRON- PRP$ cord-342150-dadc8whz 33 10 own own JJ cord-342150-dadc8whz 33 11 right right NN cord-342150-dadc8whz 33 12 , , , cord-342150-dadc8whz 33 13 with with IN cord-342150-dadc8whz 33 14 regard regard NN cord-342150-dadc8whz 33 15 to to IN cord-342150-dadc8whz 33 16 detailed detailed JJ cord-342150-dadc8whz 33 17 mechanistic mechanistic JJ cord-342150-dadc8whz 33 18 functions function NNS cord-342150-dadc8whz 33 19 . . . cord-342150-dadc8whz 34 1 It -PRON- PRP cord-342150-dadc8whz 34 2 would would MD cord-342150-dadc8whz 34 3 not not RB cord-342150-dadc8whz 34 4 be be VB cord-342150-dadc8whz 34 5 possible possible JJ cord-342150-dadc8whz 34 6 for for IN cord-342150-dadc8whz 34 7 a a DT cord-342150-dadc8whz 34 8 review review NN cord-342150-dadc8whz 34 9 like like IN cord-342150-dadc8whz 34 10 this this DT cord-342150-dadc8whz 34 11 to to TO cord-342150-dadc8whz 34 12 provide provide VB cord-342150-dadc8whz 34 13 a a DT cord-342150-dadc8whz 34 14 comprehensive comprehensive JJ cord-342150-dadc8whz 34 15 overarching overarching JJ cord-342150-dadc8whz 34 16 presentation presentation NN cord-342150-dadc8whz 34 17 of of IN cord-342150-dadc8whz 34 18 them -PRON- PRP cord-342150-dadc8whz 34 19 all all DT cord-342150-dadc8whz 34 20 . . . cord-342150-dadc8whz 35 1 Therefore therefore RB cord-342150-dadc8whz 35 2 , , , cord-342150-dadc8whz 35 3 it -PRON- PRP cord-342150-dadc8whz 35 4 was be VBD cord-342150-dadc8whz 35 5 necessary necessary JJ cord-342150-dadc8whz 35 6 to to TO cord-342150-dadc8whz 35 7 prioritise prioritise VB cord-342150-dadc8whz 35 8 key key JJ cord-342150-dadc8whz 35 9 scientific scientific JJ cord-342150-dadc8whz 35 10 areas area NNS cord-342150-dadc8whz 35 11 for for IN cord-342150-dadc8whz 35 12 this this DT cord-342150-dadc8whz 35 13 mini mini JJ cord-342150-dadc8whz 35 14 review review NN cord-342150-dadc8whz 35 15 . . . cord-342150-dadc8whz 36 1 That that DT cord-342150-dadc8whz 36 2 is be VBZ cord-342150-dadc8whz 36 3 why why WRB cord-342150-dadc8whz 36 4 the the DT cord-342150-dadc8whz 36 5 finding finding NN cord-342150-dadc8whz 36 6 on on IN cord-342150-dadc8whz 36 7 mechanisms mechanism NNS cord-342150-dadc8whz 36 8 and and CC cord-342150-dadc8whz 36 9 explanations explanation NNS cord-342150-dadc8whz 36 10 will will MD cord-342150-dadc8whz 36 11 focus focus VB cord-342150-dadc8whz 36 12 on on IN cord-342150-dadc8whz 36 13 three three CD cord-342150-dadc8whz 36 14 scientific scientific JJ cord-342150-dadc8whz 36 15 areas area NNS cord-342150-dadc8whz 36 16 : : : cord-342150-dadc8whz 36 17 gravity gravity NN cord-342150-dadc8whz 36 18 , , , cord-342150-dadc8whz 36 19 lung lung NN cord-342150-dadc8whz 36 20 structure structure NN cord-342150-dadc8whz 36 21 and and CC cord-342150-dadc8whz 36 22 fractal fractal JJ cord-342150-dadc8whz 36 23 geometry geometry NN cord-342150-dadc8whz 36 24 and and CC cord-342150-dadc8whz 36 25 vascular vascular JJ cord-342150-dadc8whz 36 26 regulation regulation NN cord-342150-dadc8whz 36 27 . . . cord-342150-dadc8whz 37 1 For for IN cord-342150-dadc8whz 37 2 many many JJ cord-342150-dadc8whz 37 3 years year NNS cord-342150-dadc8whz 37 4 , , , cord-342150-dadc8whz 37 5 pulmonary pulmonary JJ cord-342150-dadc8whz 37 6 circulation circulation NN cord-342150-dadc8whz 37 7 was be VBD cord-342150-dadc8whz 37 8 defined define VBN cord-342150-dadc8whz 37 9 according accord VBG cord-342150-dadc8whz 37 10 to to IN cord-342150-dadc8whz 37 11 gravity gravity NN cord-342150-dadc8whz 37 12 and and CC cord-342150-dadc8whz 37 13 based base VBN cord-342150-dadc8whz 37 14 on on IN cord-342150-dadc8whz 37 15 advanced advanced JJ cord-342150-dadc8whz 37 16 investigations investigation NNS cord-342150-dadc8whz 37 17 in in IN cord-342150-dadc8whz 37 18 upright upright JJ cord-342150-dadc8whz 37 19 humans human NNS cord-342150-dadc8whz 37 20 . . . cord-342150-dadc8whz 38 1 [ [ -LRB- cord-342150-dadc8whz 38 2 3 3 CD cord-342150-dadc8whz 38 3 ] ] -RRB- cord-342150-dadc8whz 38 4 [ [ -LRB- cord-342150-dadc8whz 38 5 4 4 CD cord-342150-dadc8whz 38 6 ] ] -RRB- cord-342150-dadc8whz 38 7 [ [ -LRB- cord-342150-dadc8whz 38 8 5 5 CD cord-342150-dadc8whz 38 9 ] ] -RRB- cord-342150-dadc8whz 39 1 According accord VBG cord-342150-dadc8whz 39 2 to to IN cord-342150-dadc8whz 39 3 these these DT cord-342150-dadc8whz 39 4 studies study NNS cord-342150-dadc8whz 39 5 , , , cord-342150-dadc8whz 39 6 pulmonary pulmonary JJ cord-342150-dadc8whz 39 7 circulation circulation NN cord-342150-dadc8whz 39 8 was be VBD cord-342150-dadc8whz 39 9 described describe VBN cord-342150-dadc8whz 39 10 in in IN cord-342150-dadc8whz 39 11 three three CD cord-342150-dadc8whz 39 12 zones zone NNS cord-342150-dadc8whz 39 13 . . . cord-342150-dadc8whz 40 1 This this DT cord-342150-dadc8whz 40 2 was be VBD cord-342150-dadc8whz 40 3 due due JJ cord-342150-dadc8whz 40 4 to to IN cord-342150-dadc8whz 40 5 relationships relationship NNS cord-342150-dadc8whz 40 6 between between IN cord-342150-dadc8whz 40 7 pulmonary pulmonary JJ cord-342150-dadc8whz 40 8 artery artery NN cord-342150-dadc8whz 40 9 pressure pressure NN cord-342150-dadc8whz 40 10 , , , cord-342150-dadc8whz 40 11 alveolar alveolar JJ cord-342150-dadc8whz 40 12 pressure pressure NN cord-342150-dadc8whz 40 13 and and CC cord-342150-dadc8whz 40 14 pulmonary pulmonary JJ cord-342150-dadc8whz 40 15 venous venous JJ cord-342150-dadc8whz 40 16 pressure pressure NN cord-342150-dadc8whz 40 17 from from IN cord-342150-dadc8whz 40 18 apical apical JJ cord-342150-dadc8whz 40 19 to to IN cord-342150-dadc8whz 40 20 basal basal NN cord-342150-dadc8whz 40 21 lung lung NN cord-342150-dadc8whz 40 22 regions region NNS cord-342150-dadc8whz 40 23 with with IN cord-342150-dadc8whz 40 24 increasing increase VBG cord-342150-dadc8whz 40 25 pulmonary pulmonary JJ cord-342150-dadc8whz 40 26 perfusion perfusion NN cord-342150-dadc8whz 40 27 down down IN cord-342150-dadc8whz 40 28 the the DT cord-342150-dadc8whz 40 29 lung lung NN cord-342150-dadc8whz 40 30 . . . cord-342150-dadc8whz 41 1 In in IN cord-342150-dadc8whz 41 2 addition addition NN cord-342150-dadc8whz 41 3 , , , cord-342150-dadc8whz 41 4 a a DT cord-342150-dadc8whz 41 5 fourth fourth JJ cord-342150-dadc8whz 41 6 zone zone NN cord-342150-dadc8whz 41 7 was be VBD cord-342150-dadc8whz 41 8 added add VBN cord-342150-dadc8whz 41 9 for for IN cord-342150-dadc8whz 41 10 basal basal NN cord-342150-dadc8whz 41 11 lung lung NN cord-342150-dadc8whz 41 12 regions region NNS cord-342150-dadc8whz 41 13 , , , cord-342150-dadc8whz 41 14 where where WRB cord-342150-dadc8whz 41 15 conditions condition NNS cord-342150-dadc8whz 41 16 allow allow VBP cord-342150-dadc8whz 41 17 pulmonary pulmonary JJ cord-342150-dadc8whz 41 18 interstitial interstitial JJ cord-342150-dadc8whz 41 19 pressure pressure NN cord-342150-dadc8whz 41 20 to to TO cord-342150-dadc8whz 41 21 exceed exceed VB cord-342150-dadc8whz 41 22 pulmonary pulmonary JJ cord-342150-dadc8whz 41 23 venous venous JJ cord-342150-dadc8whz 41 24 and and CC cord-342150-dadc8whz 41 25 alveolar alveolar JJ cord-342150-dadc8whz 41 26 pressures pressure NNS cord-342150-dadc8whz 41 27 . . . cord-342150-dadc8whz 42 1 These these DT cord-342150-dadc8whz 42 2 investigations investigation NNS cord-342150-dadc8whz 42 3 and and CC cord-342150-dadc8whz 42 4 physiological physiological JJ cord-342150-dadc8whz 42 5 interpretations interpretation NNS cord-342150-dadc8whz 42 6 have have VBP cord-342150-dadc8whz 42 7 played play VBN cord-342150-dadc8whz 42 8 an an DT cord-342150-dadc8whz 42 9 important important JJ cord-342150-dadc8whz 42 10 role role NN cord-342150-dadc8whz 42 11 in in IN cord-342150-dadc8whz 42 12 developing develop VBG cord-342150-dadc8whz 42 13 our -PRON- PRP$ cord-342150-dadc8whz 42 14 understanding understanding NN cord-342150-dadc8whz 42 15 of of IN cord-342150-dadc8whz 42 16 lung lung NN cord-342150-dadc8whz 42 17 function function NN cord-342150-dadc8whz 42 18 today today NN cord-342150-dadc8whz 42 19 . . . cord-342150-dadc8whz 43 1 This this DT cord-342150-dadc8whz 43 2 platform platform NN cord-342150-dadc8whz 43 3 created create VBD cord-342150-dadc8whz 43 4 new new JJ cord-342150-dadc8whz 43 5 knowledge knowledge NN cord-342150-dadc8whz 43 6 which which WDT cord-342150-dadc8whz 43 7 has have VBZ cord-342150-dadc8whz 43 8 , , , cord-342150-dadc8whz 43 9 step step NN cord-342150-dadc8whz 43 10 - - HYPH cord-342150-dadc8whz 43 11 by by IN cord-342150-dadc8whz 43 12 - - HYPH cord-342150-dadc8whz 43 13 step step NN cord-342150-dadc8whz 43 14 , , , cord-342150-dadc8whz 43 15 resulted result VBD cord-342150-dadc8whz 43 16 in in IN cord-342150-dadc8whz 43 17 advanced advanced JJ cord-342150-dadc8whz 43 18 treatment treatment NN cord-342150-dadc8whz 43 19 of of IN cord-342150-dadc8whz 43 20 the the DT cord-342150-dadc8whz 43 21 insufficient insufficient JJ cord-342150-dadc8whz 43 22 lung lung NN cord-342150-dadc8whz 43 23 . . . cord-342150-dadc8whz 44 1 • • NNP cord-342150-dadc8whz 45 1 Gravity gravity NN cord-342150-dadc8whz 45 2 is be VBZ cord-342150-dadc8whz 45 3 only only RB cord-342150-dadc8whz 45 4 one one CD cord-342150-dadc8whz 45 5 variable variable NN cord-342150-dadc8whz 45 6 responsible responsible JJ cord-342150-dadc8whz 45 7 for for IN cord-342150-dadc8whz 45 8 ventilation/ ventilation/ ADD cord-342150-dadc8whz 45 9 perfusion perfusion NN cord-342150-dadc8whz 45 10 matching matching NN cord-342150-dadc8whz 45 11 and and CC cord-342150-dadc8whz 45 12 is be VBZ cord-342150-dadc8whz 45 13 executed execute VBN cord-342150-dadc8whz 45 14 in in IN cord-342150-dadc8whz 45 15 concert concert NN cord-342150-dadc8whz 45 16 with with IN cord-342150-dadc8whz 45 17 lung lung NN cord-342150-dadc8whz 45 18 structure structure NN cord-342150-dadc8whz 45 19 and and CC cord-342150-dadc8whz 45 20 fractal fractal JJ cord-342150-dadc8whz 45 21 geometry geometry NN cord-342150-dadc8whz 45 22 , , , cord-342150-dadc8whz 45 23 gas gas NN cord-342150-dadc8whz 45 24 distribution distribution NN cord-342150-dadc8whz 45 25 and and CC cord-342150-dadc8whz 45 26 regulation regulation NN cord-342150-dadc8whz 45 27 of of IN cord-342150-dadc8whz 45 28 lung lung NN cord-342150-dadc8whz 45 29 vascular vascular JJ cord-342150-dadc8whz 45 30 tone tone NN cord-342150-dadc8whz 45 31 . . . cord-342150-dadc8whz 46 1 • • NNP cord-342150-dadc8whz 47 1 The the DT cord-342150-dadc8whz 47 2 most most RBS cord-342150-dadc8whz 47 3 important important JJ cord-342150-dadc8whz 47 4 mechanism mechanism NN cord-342150-dadc8whz 47 5 is be VBZ cord-342150-dadc8whz 47 6 the the DT cord-342150-dadc8whz 47 7 higher high JJR cord-342150-dadc8whz 47 8 expression expression NN cord-342150-dadc8whz 47 9 of of IN cord-342150-dadc8whz 47 10 nitric nitric JJ cord-342150-dadc8whz 47 11 oxide oxide NN cord-342150-dadc8whz 47 12 in in IN cord-342150-dadc8whz 47 13 dorsal dorsal JJ cord-342150-dadc8whz 47 14 lung lung NN cord-342150-dadc8whz 47 15 vessels vessel NNS cord-342150-dadc8whz 47 16 than than IN cord-342150-dadc8whz 47 17 in in IN cord-342150-dadc8whz 47 18 ventral ventral JJ cord-342150-dadc8whz 47 19 vessels vessel NNS cord-342150-dadc8whz 47 20 . . . cord-342150-dadc8whz 48 1 Chest chest NN cord-342150-dadc8whz 48 2 in in IN cord-342150-dadc8whz 48 3 1988 1988 CD cord-342150-dadc8whz 48 4 . . . cord-342150-dadc8whz 49 1 10 10 CD cord-342150-dadc8whz 49 2 _SP cord-342150-dadc8whz 50 1 Certainly certainly RB cord-342150-dadc8whz 50 2 , , , cord-342150-dadc8whz 50 3 gravity gravity NN cord-342150-dadc8whz 50 4 is be VBZ cord-342150-dadc8whz 50 5 of of IN cord-342150-dadc8whz 50 6 interest interest NN cord-342150-dadc8whz 50 7 for for IN cord-342150-dadc8whz 50 8 pulmonary pulmonary JJ cord-342150-dadc8whz 50 9 circulation circulation NN cord-342150-dadc8whz 50 10 and and CC cord-342150-dadc8whz 50 11 ventilation ventilation NN cord-342150-dadc8whz 50 12 and and CC cord-342150-dadc8whz 50 13 influences influence NNS cord-342150-dadc8whz 51 1 V V NNP cord-342150-dadc8whz 51 2 / / SYM cord-342150-dadc8whz 51 3 Q q NN cord-342150-dadc8whz 51 4 matching match VBG cord-342150-dadc8whz 51 5 along along IN cord-342150-dadc8whz 51 6 the the DT cord-342150-dadc8whz 51 7 vertical vertical JJ cord-342150-dadc8whz 51 8 axis axis NN cord-342150-dadc8whz 51 9 and and CC cord-342150-dadc8whz 51 10 , , , cord-342150-dadc8whz 51 11 more more RBR cord-342150-dadc8whz 51 12 so so RB cord-342150-dadc8whz 51 13 , , , cord-342150-dadc8whz 51 14 at at IN cord-342150-dadc8whz 51 15 the the DT cord-342150-dadc8whz 51 16 longer long JJR cord-342150-dadc8whz 51 17 distances distance NNS cord-342150-dadc8whz 51 18 down down IN cord-342150-dadc8whz 51 19 the the DT cord-342150-dadc8whz 51 20 lung lung NN cord-342150-dadc8whz 51 21 . . . cord-342150-dadc8whz 52 1 To to TO cord-342150-dadc8whz 52 2 extrapolate extrapolate VB cord-342150-dadc8whz 52 3 the the DT cord-342150-dadc8whz 52 4 importance importance NN cord-342150-dadc8whz 52 5 of of IN cord-342150-dadc8whz 52 6 gravity gravity NN cord-342150-dadc8whz 52 7 for for IN cord-342150-dadc8whz 52 8 pulmonary pulmonary JJ cord-342150-dadc8whz 52 9 circulation circulation NN cord-342150-dadc8whz 52 10 , , , cord-342150-dadc8whz 52 11 a a DT cord-342150-dadc8whz 52 12 study study NN cord-342150-dadc8whz 52 13 was be VBD cord-342150-dadc8whz 52 14 performed perform VBN cord-342150-dadc8whz 52 15 using use VBG cord-342150-dadc8whz 52 16 single single JJ cord-342150-dadc8whz 52 17 photon photon NN cord-342150-dadc8whz 52 18 emission emission NN cord-342150-dadc8whz 52 19 tomography tomography NN cord-342150-dadc8whz 52 20 in in IN cord-342150-dadc8whz 52 21 volunteers volunteer NNS cord-342150-dadc8whz 52 22 subjected subject VBN cord-342150-dadc8whz 52 23 to to IN cord-342150-dadc8whz 52 24 hypergravity hypergravity NN cord-342150-dadc8whz 52 25 of of IN cord-342150-dadc8whz 52 26 three three CD cord-342150-dadc8whz 52 27 times time NNS cord-342150-dadc8whz 52 28 normal normal JJ cord-342150-dadc8whz 52 29 gravity gravity NN cord-342150-dadc8whz 52 30 ( ( -LRB- cord-342150-dadc8whz 52 31 3 3 CD cord-342150-dadc8whz 52 32 G g NN cord-342150-dadc8whz 52 33 ) ) -RRB- cord-342150-dadc8whz 52 34 . . . cord-342150-dadc8whz 53 1 A a DT cord-342150-dadc8whz 53 2 human human JJ cord-342150-dadc8whz 53 3 centrifuge centrifuge NN cord-342150-dadc8whz 53 4 was be VBD cord-342150-dadc8whz 53 5 used use VBN cord-342150-dadc8whz 53 6 with with IN cord-342150-dadc8whz 53 7 the the DT cord-342150-dadc8whz 53 8 subjects subject NNS cord-342150-dadc8whz 53 9 in in IN cord-342150-dadc8whz 53 10 the the DT cord-342150-dadc8whz 53 11 supine supine JJ cord-342150-dadc8whz 53 12 position position NN cord-342150-dadc8whz 53 13 . . . cord-342150-dadc8whz 54 1 Interestingly interestingly RB cord-342150-dadc8whz 54 2 , , , cord-342150-dadc8whz 54 3 a a DT cord-342150-dadc8whz 54 4 paradoxical paradoxical JJ cord-342150-dadc8whz 54 5 result result NN cord-342150-dadc8whz 54 6 was be VBD cord-342150-dadc8whz 54 7 reached reach VBN cord-342150-dadc8whz 54 8 , , , cord-342150-dadc8whz 54 9 with with IN cord-342150-dadc8whz 54 10 a a DT cord-342150-dadc8whz 54 11 shift shift NN cord-342150-dadc8whz 54 12 of of IN cord-342150-dadc8whz 54 13 dominant dominant JJ cord-342150-dadc8whz 54 14 perfusion perfusion NN cord-342150-dadc8whz 54 15 from from IN cord-342150-dadc8whz 54 16 dependent dependent JJ cord-342150-dadc8whz 54 17 to to IN cord-342150-dadc8whz 54 18 independent independent JJ cord-342150-dadc8whz 54 19 lung lung NN cord-342150-dadc8whz 54 20 regions region NNS cord-342150-dadc8whz 54 21 when when WRB cord-342150-dadc8whz 54 22 the the DT cord-342150-dadc8whz 54 23 normal normal JJ cord-342150-dadc8whz 54 24 gravitational gravitational JJ cord-342150-dadc8whz 54 25 force force NN cord-342150-dadc8whz 54 26 ( ( -LRB- cord-342150-dadc8whz 54 27 0 0 CD cord-342150-dadc8whz 54 28 G G NNP cord-342150-dadc8whz 54 29 ) ) -RRB- cord-342150-dadc8whz 54 30 was be VBD cord-342150-dadc8whz 54 31 changed change VBN cord-342150-dadc8whz 54 32 to to IN cord-342150-dadc8whz 54 33 3 3 CD cord-342150-dadc8whz 54 34 G. G. NNP cord-342150-dadc8whz 54 35 16 16 CD cord-342150-dadc8whz 55 1 This this DT cord-342150-dadc8whz 55 2 paradoxical paradoxical JJ cord-342150-dadc8whz 55 3 finding finding NN cord-342150-dadc8whz 55 4 invited invite VBN cord-342150-dadc8whz 55 5 to to IN cord-342150-dadc8whz 55 6 thoughts thought NNS cord-342150-dadc8whz 55 7 on on IN cord-342150-dadc8whz 55 8 lung lung NN cord-342150-dadc8whz 55 9 structure structure NN cord-342150-dadc8whz 55 10 and and CC cord-342150-dadc8whz 55 11 to to IN cord-342150-dadc8whz 55 12 the the DT cord-342150-dadc8whz 55 13 experimental experimental JJ cord-342150-dadc8whz 55 14 study study NN cord-342150-dadc8whz 55 15 by by IN cord-342150-dadc8whz 55 16 Beck Beck NNP cord-342150-dadc8whz 55 17 and and CC cord-342150-dadc8whz 55 18 Rehder Rehder NNP cord-342150-dadc8whz 55 19 8 8 CD cord-342150-dadc8whz 55 20 using use VBG cord-342150-dadc8whz 55 21 microspheres microsphere NNS cord-342150-dadc8whz 55 22 in in IN cord-342150-dadc8whz 55 23 isolated isolated JJ cord-342150-dadc8whz 55 24 perfused perfuse VBN cord-342150-dadc8whz 55 25 dog dog NN cord-342150-dadc8whz 55 26 lungs lung NNS cord-342150-dadc8whz 55 27 . . . cord-342150-dadc8whz 56 1 They -PRON- PRP cord-342150-dadc8whz 56 2 concluded conclude VBD cord-342150-dadc8whz 56 3 that that IN cord-342150-dadc8whz 56 4 : : : cord-342150-dadc8whz 56 5 The the DT cord-342150-dadc8whz 56 6 distribution distribution NN cord-342150-dadc8whz 56 7 of of IN cord-342150-dadc8whz 56 8 regional regional JJ cord-342150-dadc8whz 56 9 vascular vascular JJ cord-342150-dadc8whz 56 10 conductances conductance NNS cord-342150-dadc8whz 56 11 were be VBD cord-342150-dadc8whz 56 12 related relate VBN cord-342150-dadc8whz 56 13 to to IN cord-342150-dadc8whz 56 14 the the DT cord-342150-dadc8whz 56 15 anatomic anatomic JJ cord-342150-dadc8whz 56 16 location location NN cord-342150-dadc8whz 56 17 and and CC cord-342150-dadc8whz 56 18 were be VBD cord-342150-dadc8whz 56 19 not not RB cord-342150-dadc8whz 56 20 related relate VBN cord-342150-dadc8whz 56 21 to to IN cord-342150-dadc8whz 56 22 gravity gravity NN cord-342150-dadc8whz 56 23 , , , cord-342150-dadc8whz 56 24 nor nor CC cord-342150-dadc8whz 56 25 were be VBD cord-342150-dadc8whz 56 26 they -PRON- PRP cord-342150-dadc8whz 56 27 caused cause VBN cord-342150-dadc8whz 56 28 by by IN cord-342150-dadc8whz 56 29 nonuniformities nonuniformity NNS cord-342150-dadc8whz 56 30 in in IN cord-342150-dadc8whz 56 31 regional regional JJ cord-342150-dadc8whz 56 32 lung lung NN cord-342150-dadc8whz 57 1 expan- expan- NNP cord-342150-dadc8whz 57 2 _SP cord-342150-dadc8whz 58 1 Like like IN cord-342150-dadc8whz 58 2 all all DT cord-342150-dadc8whz 58 3 organs organ NNS cord-342150-dadc8whz 58 4 , , , cord-342150-dadc8whz 58 5 the the DT cord-342150-dadc8whz 58 6 anatomy anatomy NN cord-342150-dadc8whz 58 7 and and CC cord-342150-dadc8whz 58 8 structure structure NN cord-342150-dadc8whz 58 9 of of IN cord-342150-dadc8whz 58 10 lungs lung NNS cord-342150-dadc8whz 58 11 are be VBP cord-342150-dadc8whz 58 12 genetically genetically RB cord-342150-dadc8whz 58 13 determined determined JJ cord-342150-dadc8whz 58 14 and and CC cord-342150-dadc8whz 58 15 are be VBP cord-342150-dadc8whz 58 16 important important JJ cord-342150-dadc8whz 58 17 pre pre JJ cord-342150-dadc8whz 58 18 - - JJ cord-342150-dadc8whz 58 19 requisite requisite JJ cord-342150-dadc8whz 58 20 conditions condition NNS cord-342150-dadc8whz 58 21 for for IN cord-342150-dadc8whz 58 22 function function NN cord-342150-dadc8whz 58 23 . . . cord-342150-dadc8whz 59 1 Embryologic Embryologic NNP cord-342150-dadc8whz 59 2 development development NN cord-342150-dadc8whz 59 3 of of IN cord-342150-dadc8whz 59 4 the the DT cord-342150-dadc8whz 59 5 lungs lung NNS cord-342150-dadc8whz 59 6 is be VBZ cord-342150-dadc8whz 59 7 characterised characterise VBN cord-342150-dadc8whz 59 8 by by IN cord-342150-dadc8whz 59 9 dichotomous dichotomous JJ cord-342150-dadc8whz 59 10 branching branching NN cord-342150-dadc8whz 59 11 of of IN cord-342150-dadc8whz 59 12 both both CC cord-342150-dadc8whz 59 13 the the DT cord-342150-dadc8whz 59 14 airways airway NNS cord-342150-dadc8whz 59 15 and and CC cord-342150-dadc8whz 59 16 vessels vessel NNS cord-342150-dadc8whz 59 17 . . . cord-342150-dadc8whz 60 1 The the DT cord-342150-dadc8whz 60 2 branching branching NN cord-342150-dadc8whz 60 3 follows follow VBZ cord-342150-dadc8whz 60 4 a a DT cord-342150-dadc8whz 60 5 genetically genetically RB cord-342150-dadc8whz 60 6 determined determine VBN cord-342150-dadc8whz 60 7 geometric geometric JJ cord-342150-dadc8whz 60 8 pattern pattern NN cord-342150-dadc8whz 60 9 , , , cord-342150-dadc8whz 60 10 such such JJ cord-342150-dadc8whz 60 11 as as IN cord-342150-dadc8whz 60 12 angles angle NNS cord-342150-dadc8whz 60 13 related relate VBN cord-342150-dadc8whz 60 14 to to IN cord-342150-dadc8whz 60 15 the the DT cord-342150-dadc8whz 60 16 common common JJ cord-342150-dadc8whz 60 17 stem stem NN cord-342150-dadc8whz 60 18 from from IN cord-342150-dadc8whz 60 19 which which WDT cord-342150-dadc8whz 60 20 the the DT cord-342150-dadc8whz 60 21 dichotomous dichotomous JJ cord-342150-dadc8whz 60 22 branching branching NN cord-342150-dadc8whz 60 23 originates originate VBZ cord-342150-dadc8whz 60 24 . . . cord-342150-dadc8whz 61 1 Also also RB cord-342150-dadc8whz 61 2 , , , cord-342150-dadc8whz 61 3 the the DT cord-342150-dadc8whz 61 4 development development NN cord-342150-dadc8whz 61 5 of of IN cord-342150-dadc8whz 61 6 airways airway NNS cord-342150-dadc8whz 61 7 and and CC cord-342150-dadc8whz 61 8 vessels vessel NNS cord-342150-dadc8whz 61 9 are be VBP cord-342150-dadc8whz 61 10 in in IN cord-342150-dadc8whz 61 11 parallel parallel NN cord-342150-dadc8whz 61 12 and and CC cord-342150-dadc8whz 61 13 happens happen VBZ cord-342150-dadc8whz 61 14 synchronously synchronously RB cord-342150-dadc8whz 61 15 . . . cord-342150-dadc8whz 62 1 This this DT cord-342150-dadc8whz 62 2 structural structural JJ cord-342150-dadc8whz 62 3 arrangement arrangement NN cord-342150-dadc8whz 62 4 will will MD cord-342150-dadc8whz 62 5 ensure ensure VB cord-342150-dadc8whz 62 6 laminar laminar JJ cord-342150-dadc8whz 62 7 transport transport NN cord-342150-dadc8whz 62 8 of of IN cord-342150-dadc8whz 62 9 both both DT cord-342150-dadc8whz 62 10 gas gas NN cord-342150-dadc8whz 62 11 and and CC cord-342150-dadc8whz 62 12 blood blood NN cord-342150-dadc8whz 62 13 to to IN cord-342150-dadc8whz 62 14 , , , cord-342150-dadc8whz 62 15 and and CC cord-342150-dadc8whz 62 16 from from IN cord-342150-dadc8whz 62 17 , , , cord-342150-dadc8whz 62 18 alveoli alveolus NNS cord-342150-dadc8whz 62 19 . . . cord-342150-dadc8whz 63 1 Altered altered JJ cord-342150-dadc8whz 63 2 angulations angulation NNS cord-342150-dadc8whz 63 3 of of IN cord-342150-dadc8whz 63 4 the the DT cord-342150-dadc8whz 63 5 fractal fractal JJ cord-342150-dadc8whz 63 6 geometry geometry NN cord-342150-dadc8whz 63 7 often often RB cord-342150-dadc8whz 63 8 cause cause VBP cord-342150-dadc8whz 63 9 turbulence turbulence NN cord-342150-dadc8whz 63 10 and and CC cord-342150-dadc8whz 63 11 increased increase VBN cord-342150-dadc8whz 63 12 resistance resistance NN cord-342150-dadc8whz 63 13 , , , cord-342150-dadc8whz 63 14 which which WDT cord-342150-dadc8whz 63 15 reduces reduce VBZ cord-342150-dadc8whz 63 16 oxygenation oxygenation NN cord-342150-dadc8whz 63 17 and and CC cord-342150-dadc8whz 63 18 gas gas NN cord-342150-dadc8whz 63 19 exchange exchange NN cord-342150-dadc8whz 63 20 ( ( -LRB- cord-342150-dadc8whz 63 21 Figure figure NN cord-342150-dadc8whz 63 22 1 1 CD cord-342150-dadc8whz 63 23 ) ) -RRB- cord-342150-dadc8whz 63 24 . . . cord-342150-dadc8whz 64 1 Fractal fractal JJ cord-342150-dadc8whz 64 2 geometry geometry NN cord-342150-dadc8whz 64 3 of of IN cord-342150-dadc8whz 64 4 the the DT cord-342150-dadc8whz 64 5 airways airway NNS cord-342150-dadc8whz 64 6 and and CC cord-342150-dadc8whz 64 7 vessels vessel NNS cord-342150-dadc8whz 64 8 has have VBZ cord-342150-dadc8whz 64 9 , , , cord-342150-dadc8whz 64 10 to to IN cord-342150-dadc8whz 64 11 a a DT cord-342150-dadc8whz 64 12 large large JJ cord-342150-dadc8whz 64 13 extent extent NN cord-342150-dadc8whz 64 14 , , , cord-342150-dadc8whz 64 15 been be VBN cord-342150-dadc8whz 64 16 clarified clarify VBN cord-342150-dadc8whz 64 17 by by IN cord-342150-dadc8whz 64 18 findings finding NNS cord-342150-dadc8whz 64 19 from from IN cord-342150-dadc8whz 64 20 the the DT cord-342150-dadc8whz 64 21 Washington Washington NNP cord-342150-dadc8whz 64 22 School School NNP cord-342150-dadc8whz 64 23 of of IN cord-342150-dadc8whz 64 24 Medicine Medicine NNP cord-342150-dadc8whz 64 25 in in IN cord-342150-dadc8whz 64 26 Seattle Seattle NNP cord-342150-dadc8whz 64 27 . . . cord-342150-dadc8whz 65 1 23 23 CD cord-342150-dadc8whz 65 2 , , , cord-342150-dadc8whz 65 3 24 24 CD cord-342150-dadc8whz 65 4 Investigations investigation NNS cord-342150-dadc8whz 65 5 using use VBG cord-342150-dadc8whz 65 6 microspheres microsphere NNS cord-342150-dadc8whz 65 7 found find VBD cord-342150-dadc8whz 65 8 that that IN cord-342150-dadc8whz 65 9 small small JJ cord-342150-dadc8whz 65 10 29 29 CD cord-342150-dadc8whz 65 11 Single single JJ cord-342150-dadc8whz 65 12 photon photon NN cord-342150-dadc8whz 65 13 emission emission NN cord-342150-dadc8whz 65 14 computed compute VBN cord-342150-dadc8whz 65 15 tomography tomography NN cord-342150-dadc8whz 65 16 image image NN cord-342150-dadc8whz 65 17 of of IN cord-342150-dadc8whz 65 18 pulmonary pulmonary JJ cord-342150-dadc8whz 65 19 perfusion perfusion NN cord-342150-dadc8whz 65 20 in in IN cord-342150-dadc8whz 65 21 one one CD cord-342150-dadc8whz 65 22 supine supine JJ cord-342150-dadc8whz 65 23 volunteer volunteer NN cord-342150-dadc8whz 65 24 before before IN cord-342150-dadc8whz 65 25 ( ( -LRB- cord-342150-dadc8whz 65 26 A a NN cord-342150-dadc8whz 65 27 ) ) -RRB- cord-342150-dadc8whz 65 28 and and CC cord-342150-dadc8whz 65 29 after after IN cord-342150-dadc8whz 65 30 ( ( -LRB- cord-342150-dadc8whz 65 31 B b NN cord-342150-dadc8whz 65 32 ) ) -RRB- cord-342150-dadc8whz 65 33 NOS NOS NNP cord-342150-dadc8whz 65 34 inhibition inhibition NN cord-342150-dadc8whz 65 35 using use VBG cord-342150-dadc8whz 65 36 L L NNP cord-342150-dadc8whz 65 37 - - HYPH cord-342150-dadc8whz 65 38 NMMA NMMA NNP cord-342150-dadc8whz 65 39 intravenously intravenously RB cord-342150-dadc8whz 65 40 . . . cord-342150-dadc8whz 66 1 R R NNP cord-342150-dadc8whz 66 2 indicates indicate VBZ cord-342150-dadc8whz 66 3 the the DT cord-342150-dadc8whz 66 4 right right JJ cord-342150-dadc8whz 66 5 lung lung NN cord-342150-dadc8whz 67 1 The the DT cord-342150-dadc8whz 67 2 finding finding NN cord-342150-dadc8whz 67 3 that that IN cord-342150-dadc8whz 67 4 vascular vascular JJ cord-342150-dadc8whz 67 5 conductance conductance NN cord-342150-dadc8whz 67 6 in in IN cord-342150-dadc8whz 67 7 dogs dog NNS cord-342150-dadc8whz 67 8 was be VBD cord-342150-dadc8whz 67 9 greater great JJR cord-342150-dadc8whz 67 10 in in IN cord-342150-dadc8whz 67 11 dorsal dorsal NN cord-342150-dadc8whz 67 12 than than IN cord-342150-dadc8whz 67 13 in in IN cord-342150-dadc8whz 67 14 ventral ventral JJ cord-342150-dadc8whz 67 15 lung lung NN cord-342150-dadc8whz 67 16 vasculature vasculature NN cord-342150-dadc8whz 67 17 clearly clearly RB cord-342150-dadc8whz 67 18 indicated indicate VBD cord-342150-dadc8whz 67 19 that that IN cord-342150-dadc8whz 67 20 there there EX cord-342150-dadc8whz 67 21 ought ought MD cord-342150-dadc8whz 67 22 to to TO cord-342150-dadc8whz 67 23 be be VB cord-342150-dadc8whz 67 24 vasoactive vasoactive JJ cord-342150-dadc8whz 67 25 mechanisms mechanism NNS cord-342150-dadc8whz 67 26 in in IN cord-342150-dadc8whz 67 27 the the DT cord-342150-dadc8whz 67 28 lungs lung NNS cord-342150-dadc8whz 67 29 that that WDT cord-342150-dadc8whz 67 30 were be VBD cord-342150-dadc8whz 67 31 counteracting counteract VBG cord-342150-dadc8whz 67 32 gravity gravity NN cord-342150-dadc8whz 67 33 . . . cord-342150-dadc8whz 68 1 8 8 CD cord-342150-dadc8whz 69 1 Another another DT cord-342150-dadc8whz 69 2 important important JJ cord-342150-dadc8whz 69 3 observation observation NN cord-342150-dadc8whz 69 4 was be VBD cord-342150-dadc8whz 69 5 in in IN cord-342150-dadc8whz 69 6 1996 1996 CD cord-342150-dadc8whz 69 7 , , , cord-342150-dadc8whz 69 8 when when WRB cord-342150-dadc8whz 69 9 Hlastala Hlastala NNP cord-342150-dadc8whz 69 10 et et NNP cord-342150-dadc8whz 69 11 al al NNP cord-342150-dadc8whz 69 12 , , , cord-342150-dadc8whz 69 13 found find VBD cord-342150-dadc8whz 69 14 that that IN cord-342150-dadc8whz 69 15 lung lung NN cord-342150-dadc8whz 69 16 perfusion perfusion NN cord-342150-dadc8whz 69 17 in in IN cord-342150-dadc8whz 69 18 standing stand VBG cord-342150-dadc8whz 69 19 horses horse NNS cord-342150-dadc8whz 69 20 was be VBD cord-342150-dadc8whz 69 21 not not RB cord-342150-dadc8whz 69 22 dominantly dominantly RB cord-342150-dadc8whz 69 23 governed govern VBN cord-342150-dadc8whz 69 24 by by IN cord-342150-dadc8whz 69 25 gravity gravity NN cord-342150-dadc8whz 69 26 . . . cord-342150-dadc8whz 70 1 27 27 CD cord-342150-dadc8whz 71 1 This this DT cord-342150-dadc8whz 71 2 was be VBD cord-342150-dadc8whz 71 3 a a DT cord-342150-dadc8whz 71 4 valuable valuable JJ cord-342150-dadc8whz 71 5 step step NN cord-342150-dadc8whz 71 6 as as IN cord-342150-dadc8whz 71 7 it -PRON- PRP cord-342150-dadc8whz 71 8 narrowed narrow VBD cord-342150-dadc8whz 71 9 down down RP cord-342150-dadc8whz 71 10 several several JJ cord-342150-dadc8whz 71 11 possibilities possibility NNS cord-342150-dadc8whz 71 12 that that WDT cord-342150-dadc8whz 71 13 might may MD cord-342150-dadc8whz 71 14 constitute constitute VB cord-342150-dadc8whz 71 15 the the DT cord-342150-dadc8whz 71 16 most most RBS cord-342150-dadc8whz 71 17 responsible responsible JJ cord-342150-dadc8whz 71 18 mechanism mechanism NN cord-342150-dadc8whz 71 19 for for IN cord-342150-dadc8whz 71 20 improved improved JJ cord-342150-dadc8whz 71 21 V V NNP cord-342150-dadc8whz 71 22 / / SYM cord-342150-dadc8whz 71 23 Q q NN cord-342150-dadc8whz 71 24 matching match VBG cord-342150-dadc8whz 71 25 in in IN cord-342150-dadc8whz 71 26 the the DT cord-342150-dadc8whz 71 27 prone prone JJ cord-342150-dadc8whz 71 28 position position NN cord-342150-dadc8whz 71 29 . . . cord-342150-dadc8whz 72 1 A a DT cord-342150-dadc8whz 72 2 next next JJ cord-342150-dadc8whz 72 3 step step NN cord-342150-dadc8whz 72 4 was be VBD cord-342150-dadc8whz 72 5 to to TO cord-342150-dadc8whz 72 6 explore explore VB cord-342150-dadc8whz 72 7 whether whether IN cord-342150-dadc8whz 72 8 NO no DT cord-342150-dadc8whz 72 9 production production NN cord-342150-dadc8whz 72 10 in in IN cord-342150-dadc8whz 72 11 human human JJ cord-342150-dadc8whz 72 12 lung lung NN cord-342150-dadc8whz 72 13 vasculature vasculature NN cord-342150-dadc8whz 72 14 could could MD cord-342150-dadc8whz 72 15 be be VB cord-342150-dadc8whz 72 16 responsible responsible JJ cord-342150-dadc8whz 72 17 for for IN cord-342150-dadc8whz 72 18 improved improved JJ cord-342150-dadc8whz 72 19 V v NN cord-342150-dadc8whz 72 20 / / SYM cord-342150-dadc8whz 72 21 Q q NN cord-342150-dadc8whz 72 22 matching match VBG cord-342150-dadc8whz 72 23 in in IN cord-342150-dadc8whz 72 24 the the DT cord-342150-dadc8whz 72 25 prone prone JJ cord-342150-dadc8whz 72 26 position position NN cord-342150-dadc8whz 72 27 . . . cord-342150-dadc8whz 73 1 An an DT cord-342150-dadc8whz 73 2 investigation investigation NN cord-342150-dadc8whz 73 3 was be VBD cord-342150-dadc8whz 73 4 designed design VBN cord-342150-dadc8whz 73 5 to to TO cord-342150-dadc8whz 73 6 challenge challenge VB cord-342150-dadc8whz 73 7 the the DT cord-342150-dadc8whz 73 8 hypothesis hypothesis NN cord-342150-dadc8whz 73 9 that that WDT cord-342150-dadc8whz 73 10 NO no DT cord-342150-dadc8whz 73 11 plays play VBZ cord-342150-dadc8whz 73 12 an an DT cord-342150-dadc8whz 73 13 important important JJ cord-342150-dadc8whz 73 14 role role NN cord-342150-dadc8whz 73 15 in in IN cord-342150-dadc8whz 73 16 the the DT cord-342150-dadc8whz 73 17 regulation regulation NN cord-342150-dadc8whz 73 18 of of IN cord-342150-dadc8whz 73 19 regional regional JJ cord-342150-dadc8whz 73 20 lung lung NN cord-342150-dadc8whz 73 21 perfusion perfusion NN cord-342150-dadc8whz 73 22 . . . cord-342150-dadc8whz 74 1 Nitric nitric NN cord-342150-dadc8whz 74 2 oxide oxide NN cord-342150-dadc8whz 74 3 synthase synthase NN cord-342150-dadc8whz 74 4 ( ( -LRB- cord-342150-dadc8whz 74 5 NOS NOS NNP cord-342150-dadc8whz 74 6 ) ) -RRB- cord-342150-dadc8whz 74 7 messenger messenger NN cord-342150-dadc8whz 74 8 ribonucleic ribonucleic NN cord-342150-dadc8whz 74 9 acid acid NN cord-342150-dadc8whz 74 10 ( ( -LRB- cord-342150-dadc8whz 74 11 mRNA mRNA NNP cord-342150-dadc8whz 74 12 ) ) -RRB- cord-342150-dadc8whz 74 13 and and CC cord-342150-dadc8whz 74 14 NOS NOS NNP cord-342150-dadc8whz 74 15 activity activity NN cord-342150-dadc8whz 74 16 using use VBG cord-342150-dadc8whz 74 17 citrulline citrulline NN cord-342150-dadc8whz 74 18 assay assay NN cord-342150-dadc8whz 74 19 were be VBD cord-342150-dadc8whz 74 20 analysed analyse VBN cord-342150-dadc8whz 74 21 in in IN cord-342150-dadc8whz 74 22 ventral ventral JJ cord-342150-dadc8whz 74 23 and and CC cord-342150-dadc8whz 74 24 dorsal dorsal JJ cord-342150-dadc8whz 74 25 lung lung NN cord-342150-dadc8whz 74 26 tissue tissue NN cord-342150-dadc8whz 74 27 samples sample NNS cord-342150-dadc8whz 74 28 from from IN cord-342150-dadc8whz 74 29 patients patient NNS cord-342150-dadc8whz 74 30 subjected subject VBN cord-342150-dadc8whz 74 31 to to IN cord-342150-dadc8whz 74 32 lung lung NN cord-342150-dadc8whz 74 33 surgery surgery NN cord-342150-dadc8whz 74 34 . . . cord-342150-dadc8whz 75 1 29 29 CD cord-342150-dadc8whz 76 1 In in IN cord-342150-dadc8whz 76 2 addition addition NN cord-342150-dadc8whz 76 3 , , , cord-342150-dadc8whz 76 4 the the DT cord-342150-dadc8whz 76 5 study study NN cord-342150-dadc8whz 76 6 also also RB cord-342150-dadc8whz 76 7 assessed assess VBD cord-342150-dadc8whz 76 8 regional regional JJ cord-342150-dadc8whz 76 9 lung lung NN cord-342150-dadc8whz 76 10 perfusion perfusion NN cord-342150-dadc8whz 76 11 in in IN cord-342150-dadc8whz 76 12 volunteers volunteer NNS cord-342150-dadc8whz 76 13 by by IN cord-342150-dadc8whz 76 14 single single JJ cord-342150-dadc8whz 76 15 photon photon NN cord-342150-dadc8whz 76 16 emission emission NN cord-342150-dadc8whz 76 17 computed compute VBN cord-342150-dadc8whz 76 18 tomography tomography NN cord-342150-dadc8whz 76 19 before before IN cord-342150-dadc8whz 76 20 and and CC cord-342150-dadc8whz 76 21 after after IN cord-342150-dadc8whz 76 22 NOS NOS NNP cord-342150-dadc8whz 76 23 inhibition inhibition NN cord-342150-dadc8whz 76 24 . . . cord-342150-dadc8whz 77 1 The the DT cord-342150-dadc8whz 77 2 hypothesis hypothesis NN cord-342150-dadc8whz 77 3 was be VBD cord-342150-dadc8whz 77 4 supported support VBN cord-342150-dadc8whz 77 5 , , , cord-342150-dadc8whz 77 6 and and CC cord-342150-dadc8whz 77 7 it -PRON- PRP cord-342150-dadc8whz 77 8 was be VBD cord-342150-dadc8whz 77 9 found find VBN cord-342150-dadc8whz 77 10 that that IN cord-342150-dadc8whz 77 11 mRNA mRNA NNP cord-342150-dadc8whz 77 12 expression expression NN cord-342150-dadc8whz 77 13 of of IN cord-342150-dadc8whz 77 14 endothelial endothelial JJ cord-342150-dadc8whz 77 15 NOS NOS NNP cord-342150-dadc8whz 77 16 was be VBD cord-342150-dadc8whz 77 17 higher high JJR cord-342150-dadc8whz 77 18 in in IN cord-342150-dadc8whz 77 19 dorsal dorsal NN cord-342150-dadc8whz 77 20 than than IN cord-342150-dadc8whz 77 21 in in IN cord-342150-dadc8whz 77 22 ventral ventral JJ cord-342150-dadc8whz 77 23 lung lung NN cord-342150-dadc8whz 77 24 regions region NNS cord-342150-dadc8whz 77 25 . . . cord-342150-dadc8whz 78 1 Moreover moreover RB cord-342150-dadc8whz 78 2 , , , cord-342150-dadc8whz 78 3 it -PRON- PRP cord-342150-dadc8whz 78 4 was be VBD cord-342150-dadc8whz 78 5 found find VBN cord-342150-dadc8whz 78 6 that that IN cord-342150-dadc8whz 78 7 calcium calcium NN cord-342150-dadc8whz 78 8 - - HYPH cord-342150-dadc8whz 78 9 dependent dependent JJ cord-342150-dadc8whz 78 10 NOS NOS NNP cord-342150-dadc8whz 78 11 activity activity NN cord-342150-dadc8whz 78 12 in in IN cord-342150-dadc8whz 78 13 citrulline citrulline NN cord-342150-dadc8whz 78 14 units unit NNS cord-342150-dadc8whz 78 15 was be VBD cord-342150-dadc8whz 78 16 higher high JJR cord-342150-dadc8whz 78 17 in in IN cord-342150-dadc8whz 78 18 dorsal dorsal NN cord-342150-dadc8whz 78 19 than than IN cord-342150-dadc8whz 78 20 ventral ventral JJ cord-342150-dadc8whz 78 21 lung lung NN cord-342150-dadc8whz 78 22 whereas whereas IN cord-342150-dadc8whz 78 23 calcium calcium NN cord-342150-dadc8whz 78 24 - - HYPH cord-342150-dadc8whz 78 25 independent independent JJ cord-342150-dadc8whz 78 26 NOS NOS NNP cord-342150-dadc8whz 78 27 activity activity NN cord-342150-dadc8whz 78 28 was be VBD cord-342150-dadc8whz 78 29 similar similar JJ cord-342150-dadc8whz 78 30 in in IN cord-342150-dadc8whz 78 31 ventral ventral JJ cord-342150-dadc8whz 78 32 and and CC cord-342150-dadc8whz 78 33 dorsal dorsal JJ cord-342150-dadc8whz 78 34 regions region NNS cord-342150-dadc8whz 78 35 ( ( -LRB- cord-342150-dadc8whz 78 36 Figure figure NN cord-342150-dadc8whz 78 37 2A 2a CD cord-342150-dadc8whz 78 38 _SP cord-342150-dadc8whz 79 1 Based base VBN cord-342150-dadc8whz 79 2 on on IN cord-342150-dadc8whz 79 3 this this DT cord-342150-dadc8whz 79 4 review review NN cord-342150-dadc8whz 79 5 , , , cord-342150-dadc8whz 79 6 it -PRON- PRP cord-342150-dadc8whz 79 7 is be VBZ cord-342150-dadc8whz 79 8 concluded conclude VBN cord-342150-dadc8whz 79 9 that that IN cord-342150-dadc8whz 79 10 gravity gravity NN cord-342150-dadc8whz 79 11 is be VBZ cord-342150-dadc8whz 79 12 one one CD cord-342150-dadc8whz 79 13 of of IN cord-342150-dadc8whz 79 14 the the DT cord-342150-dadc8whz 79 15 variables variable NNS cord-342150-dadc8whz 79 16 responsible responsible JJ cord-342150-dadc8whz 79 17 for for IN cord-342150-dadc8whz 79 18 V V NNP cord-342150-dadc8whz 79 19 / / SYM cord-342150-dadc8whz 79 20 Q q NN cord-342150-dadc8whz 79 21 matching matching NN cord-342150-dadc8whz 79 22 , , , cord-342150-dadc8whz 79 23 but but CC cord-342150-dadc8whz 79 24 in in IN cord-342150-dadc8whz 79 25 concert concert NN cord-342150-dadc8whz 79 26 with with IN cord-342150-dadc8whz 79 27 lung lung NN cord-342150-dadc8whz 79 28 structure structure NN cord-342150-dadc8whz 79 29 and and CC cord-342150-dadc8whz 79 30 fractal fractal JJ cord-342150-dadc8whz 79 31 geometry geometry NN cord-342150-dadc8whz 79 32 , , , cord-342150-dadc8whz 79 33 gas gas NN cord-342150-dadc8whz 79 34 distribution distribution NN cord-342150-dadc8whz 79 35 and and CC cord-342150-dadc8whz 79 36 regulation regulation NN cord-342150-dadc8whz 79 37 of of IN cord-342150-dadc8whz 79 38 lung lung NN cord-342150-dadc8whz 79 39 vascular vascular JJ cord-342150-dadc8whz 79 40 tone tone NN cord-342150-dadc8whz 79 41 . . . cord-342150-dadc8whz 80 1 This this DT cord-342150-dadc8whz 80 2 conclusion conclusion NN cord-342150-dadc8whz 80 3 is be VBZ cord-342150-dadc8whz 80 4 based base VBN cord-342150-dadc8whz 80 5 on on IN cord-342150-dadc8whz 80 6 a a DT cord-342150-dadc8whz 80 7 long long JJ cord-342150-dadc8whz 80 8 series series NN cord-342150-dadc8whz 80 9 of of IN cord-342150-dadc8whz 80 10 investigations investigation NNS cord-342150-dadc8whz 80 11 published publish VBN cord-342150-dadc8whz 80 12 in in IN cord-342150-dadc8whz 80 13 leading lead VBG cord-342150-dadc8whz 80 14 journals journal NNS cord-342150-dadc8whz 80 15 and and CC cord-342150-dadc8whz 80 16 illustrates illustrate VBZ cord-342150-dadc8whz 80 17 the the DT cord-342150-dadc8whz 80 18 essence essence NN cord-342150-dadc8whz 80 19 of of IN cord-342150-dadc8whz 80 20 science science NN cord-342150-dadc8whz 80 21 , , , cord-342150-dadc8whz 80 22 where where WRB cord-342150-dadc8whz 80 23 brick brick NN cord-342150-dadc8whz 80 24 is be VBZ cord-342150-dadc8whz 80 25 laid lay VBN cord-342150-dadc8whz 80 26 on on IN cord-342150-dadc8whz 80 27 brick brick NN cord-342150-dadc8whz 80 28 in in IN cord-342150-dadc8whz 80 29 a a DT cord-342150-dadc8whz 80 30 process process NN cord-342150-dadc8whz 80 31 of of IN cord-342150-dadc8whz 80 32 continued continue VBN cord-342150-dadc8whz 80 33 development development NN cord-342150-dadc8whz 80 34 . . . cord-342150-dadc8whz 81 1 In in IN cord-342150-dadc8whz 81 2 view view NN cord-342150-dadc8whz 81 3 of of IN cord-342150-dadc8whz 81 4 the the DT cord-342150-dadc8whz 81 5 unchanged unchanged JJ cord-342150-dadc8whz 81 6 ventilation ventilation NN cord-342150-dadc8whz 81 7 distribution distribution NN cord-342150-dadc8whz 81 8 of of IN cord-342150-dadc8whz 81 9 prone prone JJ cord-342150-dadc8whz 81 10 and and CC cord-342150-dadc8whz 81 11 supine supine JJ cord-342150-dadc8whz 81 12 , , , cord-342150-dadc8whz 81 13 it -PRON- PRP cord-342150-dadc8whz 81 14 currently currently RB cord-342150-dadc8whz 81 15 seems seem VBZ cord-342150-dadc8whz 81 16 that that IN cord-342150-dadc8whz 81 17 the the DT cord-342150-dadc8whz 81 18 most most RBS cord-342150-dadc8whz 81 19 important important JJ cord-342150-dadc8whz 81 20 mechanism mechanism NN cord-342150-dadc8whz 81 21 is be VBZ cord-342150-dadc8whz 81 22 different different JJ cord-342150-dadc8whz 81 23 regulation regulation NN cord-342150-dadc8whz 81 24 of of IN cord-342150-dadc8whz 81 25 lung lung NN cord-342150-dadc8whz 81 26 vascularity vascularity NN cord-342150-dadc8whz 81 27 in in IN cord-342150-dadc8whz 81 28 dorsal dorsal JJ cord-342150-dadc8whz 81 29 and and CC cord-342150-dadc8whz 81 30 ventral ventral JJ cord-342150-dadc8whz 81 31 lung lung NN cord-342150-dadc8whz 81 32 regions region NNS cord-342150-dadc8whz 81 33 , , , cord-342150-dadc8whz 81 34 due due IN cord-342150-dadc8whz 81 35 to to IN cord-342150-dadc8whz 81 36 expression expression NN cord-342150-dadc8whz 81 37 of of IN cord-342150-dadc8whz 81 38 the the DT cord-342150-dadc8whz 81 39 potent potent JJ cord-342150-dadc8whz 81 40 vasodilator vasodilator NN cord-342150-dadc8whz 81 41 NO no NN cord-342150-dadc8whz 81 42 . . . cord-342150-dadc8whz 82 1 This this DT cord-342150-dadc8whz 82 2 mechanism mechanism NN cord-342150-dadc8whz 82 3 is be VBZ cord-342150-dadc8whz 82 4 also also RB cord-342150-dadc8whz 82 5 present present JJ cord-342150-dadc8whz 82 6 in in IN cord-342150-dadc8whz 82 7 horses horse NNS cord-342150-dadc8whz 82 8 and and CC cord-342150-dadc8whz 82 9 in in IN cord-342150-dadc8whz 82 10 pigs pig NNS cord-342150-dadc8whz 82 11 making make VBG cord-342150-dadc8whz 82 12 it -PRON- PRP cord-342150-dadc8whz 82 13 likely likely JJ cord-342150-dadc8whz 82 14 that that IN cord-342150-dadc8whz 82 15 the the DT cord-342150-dadc8whz 82 16 enhanced enhanced JJ cord-342150-dadc8whz 82 17 NO no DT cord-342150-dadc8whz 82 18 production production NN cord-342150-dadc8whz 82 19 in in IN cord-342150-dadc8whz 82 20 dorsal dorsal JJ cord-342150-dadc8whz 82 21 lung lung NN cord-342150-dadc8whz 82 22 regions region NNS cord-342150-dadc8whz 82 23 is be VBZ cord-342150-dadc8whz 82 24 an an DT cord-342150-dadc8whz 82 25 evolutionary evolutionary JJ cord-342150-dadc8whz 82 26 trait trait NN cord-342150-dadc8whz 82 27 preserved preserve VBN cord-342150-dadc8whz 82 28 from from IN cord-342150-dadc8whz 82 29 the the DT cord-342150-dadc8whz 82 30 time time NN cord-342150-dadc8whz 82 31 when when WRB cord-342150-dadc8whz 82 32 we -PRON- PRP cord-342150-dadc8whz 82 33 walked walk VBD cord-342150-dadc8whz 82 34 on on IN cord-342150-dadc8whz 82 35 four four CD cord-342150-dadc8whz 82 36 legs leg NNS cord-342150-dadc8whz 82 37 . . . cord-342150-dadc8whz 83 1 It -PRON- PRP cord-342150-dadc8whz 83 2 is be VBZ cord-342150-dadc8whz 83 3 very very RB cord-342150-dadc8whz 83 4 likely likely JJ cord-342150-dadc8whz 83 5 that that IN cord-342150-dadc8whz 83 6 there there EX cord-342150-dadc8whz 83 7 is be VBZ cord-342150-dadc8whz 83 8 more more JJR cord-342150-dadc8whz 83 9 to to TO cord-342150-dadc8whz 83 10 know know VB cord-342150-dadc8whz 83 11 , , , cord-342150-dadc8whz 83 12 and and CC cord-342150-dadc8whz 83 13 understand understand VB cord-342150-dadc8whz 83 14 , , , cord-342150-dadc8whz 83 15 about about IN cord-342150-dadc8whz 83 16 the the DT cord-342150-dadc8whz 83 17 complex complex JJ cord-342150-dadc8whz 83 18 lung lung NN cord-342150-dadc8whz 83 19 function function NN cord-342150-dadc8whz 83 20 which which WDT cord-342150-dadc8whz 83 21 will will MD cord-342150-dadc8whz 83 22 be be VB cord-342150-dadc8whz 83 23 further further RB cord-342150-dadc8whz 83 24 elucidated elucidate VBN cord-342150-dadc8whz 83 25 in in IN cord-342150-dadc8whz 83 26 future future JJ cord-342150-dadc8whz 83 27 investigations investigation NNS cord-342150-dadc8whz 83 28 . . . cord-342150-dadc8whz 84 1 Based base VBN cord-342150-dadc8whz 84 2 on on IN cord-342150-dadc8whz 84 3 the the DT cord-342150-dadc8whz 84 4 above above JJ cord-342150-dadc8whz 84 5 findings finding NNS cord-342150-dadc8whz 84 6 , , , cord-342150-dadc8whz 84 7 it -PRON- PRP cord-342150-dadc8whz 84 8 appears appear VBZ cord-342150-dadc8whz 84 9 that that IN cord-342150-dadc8whz 84 10 using use VBG cord-342150-dadc8whz 84 11 the the DT cord-342150-dadc8whz 84 12 prone prone JJ cord-342150-dadc8whz 84 13 position position NN cord-342150-dadc8whz 84 14 to to TO cord-342150-dadc8whz 84 15 combat combat VB cord-342150-dadc8whz 84 16 the the DT cord-342150-dadc8whz 84 17 fast fast JJ cord-342150-dadc8whz 84 18 development development NN cord-342150-dadc8whz 84 19 of of IN cord-342150-dadc8whz 84 20 deep deep JJ cord-342150-dadc8whz 84 21 hypoxia hypoxia NN cord-342150-dadc8whz 84 22 in in IN cord-342150-dadc8whz 84 23 some some DT cord-342150-dadc8whz 84 24 patients patient NNS cord-342150-dadc8whz 84 25 with with IN cord-342150-dadc8whz 84 26 COVID-19 COVID-19 NNP cord-342150-dadc8whz 84 27 is be VBZ cord-342150-dadc8whz 84 28 a a DT cord-342150-dadc8whz 84 29 useful useful JJ cord-342150-dadc8whz 84 30 tool tool NN cord-342150-dadc8whz 84 31 . . . cord-342150-dadc8whz 85 1 This this DT cord-342150-dadc8whz 85 2 could could MD cord-342150-dadc8whz 85 3 even even RB cord-342150-dadc8whz 85 4 be be VB cord-342150-dadc8whz 85 5 used use VBN cord-342150-dadc8whz 85 6 in in IN cord-342150-dadc8whz 85 7 spontaneously spontaneously RB cord-342150-dadc8whz 85 8 breathing breathe VBG cord-342150-dadc8whz 85 9 patients patient NNS cord-342150-dadc8whz 85 10 with with IN cord-342150-dadc8whz 85 11 deep deep JJ cord-342150-dadc8whz 85 12 hypoxaemia hypoxaemia NN cord-342150-dadc8whz 85 13 prior prior RB cord-342150-dadc8whz 85 14 to to IN cord-342150-dadc8whz 85 15 initiation initiation NN cord-342150-dadc8whz 85 16 of of IN cord-342150-dadc8whz 85 17 mechanical mechanical JJ cord-342150-dadc8whz 85 18 ventilation ventilation NN cord-342150-dadc8whz 85 19 and and CC cord-342150-dadc8whz 85 20 extra extra JJ cord-342150-dadc8whz 85 21 corporeal corporeal JJ cord-342150-dadc8whz 85 22 oxygenation oxygenation NN cord-342150-dadc8whz 85 23 . . . cord-342150-dadc8whz 86 1 The the DT cord-342150-dadc8whz 86 2 author author NN cord-342150-dadc8whz 86 3 has have VBZ cord-342150-dadc8whz 86 4 no no DT cord-342150-dadc8whz 86 5 conflicts conflict NNS cord-342150-dadc8whz 86 6 of of IN cord-342150-dadc8whz 86 7 interest interest NN cord-342150-dadc8whz 86 8 to to TO cord-342150-dadc8whz 86 9 declare declare VB cord-342150-dadc8whz 86 10 . . . cord-342150-dadc8whz 87 1 Prone prone JJ cord-342150-dadc8whz 87 2 positioning positioning NN cord-342150-dadc8whz 87 3 in in IN cord-342150-dadc8whz 88 1 acute acute JJ cord-342150-dadc8whz 88 2 respiratory respiratory JJ cord-342150-dadc8whz 88 3 distress distress NN cord-342150-dadc8whz 88 4 syndrome syndrome NN cord-342150-dadc8whz 88 5 Prone prone JJ cord-342150-dadc8whz 88 6 positioning positioning NN cord-342150-dadc8whz 88 7 in in IN cord-342150-dadc8whz 88 8 severe severe JJ cord-342150-dadc8whz 88 9 acute acute JJ cord-342150-dadc8whz 88 10 respiratory respiratory JJ cord-342150-dadc8whz 88 11 distress distress NN cord-342150-dadc8whz 88 12 syndrome syndrome NN cord-342150-dadc8whz 88 13 Distribution distribution NN cord-342150-dadc8whz 88 14 of of IN cord-342150-dadc8whz 88 15 blood blood NN cord-342150-dadc8whz 88 16 flow flow NN cord-342150-dadc8whz 88 17 in in IN cord-342150-dadc8whz 88 18 isolated isolated JJ cord-342150-dadc8whz 88 19 lung lung NN cord-342150-dadc8whz 88 20 ; ; : cord-342150-dadc8whz 88 21 relation relation NN cord-342150-dadc8whz 88 22 to to IN cord-342150-dadc8whz 88 23 vascular vascular JJ cord-342150-dadc8whz 88 24 and and CC cord-342150-dadc8whz 88 25 alveolar alveolar JJ cord-342150-dadc8whz 88 26 pressures pressure NNS cord-342150-dadc8whz 88 27 Effect Effect NNP cord-342150-dadc8whz 88 28 of of IN cord-342150-dadc8whz 88 29 lung lung NN cord-342150-dadc8whz 88 30 volume volume NN cord-342150-dadc8whz 88 31 on on IN cord-342150-dadc8whz 88 32 the the DT cord-342150-dadc8whz 88 33 distribution distribution NN cord-342150-dadc8whz 88 34 of of IN cord-342150-dadc8whz 88 35 pulmonary pulmonary JJ cord-342150-dadc8whz 88 36 blood blood NN cord-342150-dadc8whz 88 37 flow flow NN cord-342150-dadc8whz 88 38 in in IN cord-342150-dadc8whz 88 39 man man NN cord-342150-dadc8whz 88 40 Effect effect NN cord-342150-dadc8whz 88 41 of of IN cord-342150-dadc8whz 88 42 extra extra JJ cord-342150-dadc8whz 88 43 - - HYPH cord-342150-dadc8whz 88 44 alveolar alveolar JJ cord-342150-dadc8whz 88 45 vessels vessel NNS cord-342150-dadc8whz 88 46 on on IN cord-342150-dadc8whz 88 47 distribution distribution NN cord-342150-dadc8whz 88 48 of of IN cord-342150-dadc8whz 88 49 blood blood NN cord-342150-dadc8whz 88 50 flow flow NN cord-342150-dadc8whz 88 51 in in IN cord-342150-dadc8whz 88 52 the the DT cord-342150-dadc8whz 88 53 dog dog NN cord-342150-dadc8whz 88 54 lung lung NN cord-342150-dadc8whz 88 55 Use Use NNP cord-342150-dadc8whz 88 56 of of IN cord-342150-dadc8whz 88 57 extreme extreme JJ cord-342150-dadc8whz 88 58 position position NN cord-342150-dadc8whz 88 59 changes change NNS cord-342150-dadc8whz 88 60 in in IN cord-342150-dadc8whz 88 61 acute acute JJ cord-342150-dadc8whz 88 62 respiratory respiratory JJ cord-342150-dadc8whz 88 63 failure failure NN cord-342150-dadc8whz 89 1 Improved improved JJ cord-342150-dadc8whz 89 2 oxygenation oxygenation NN cord-342150-dadc8whz 89 3 in in IN cord-342150-dadc8whz 89 4 patients patient NNS cord-342150-dadc8whz 89 5 with with IN cord-342150-dadc8whz 89 6 acute acute JJ cord-342150-dadc8whz 89 7 respiratory respiratory JJ cord-342150-dadc8whz 89 8 failure failure NN cord-342150-dadc8whz 89 9 : : : cord-342150-dadc8whz 90 1 the the DT cord-342150-dadc8whz 90 2 prone prone JJ cord-342150-dadc8whz 90 3 position position NN cord-342150-dadc8whz 90 4 Differences difference NNS cord-342150-dadc8whz 90 5 in in IN cord-342150-dadc8whz 90 6 regional regional JJ cord-342150-dadc8whz 90 7 vascular vascular JJ cord-342150-dadc8whz 90 8 conductances conductance NNS cord-342150-dadc8whz 90 9 in in IN cord-342150-dadc8whz 90 10 isolated isolate VBN cord-342150-dadc8whz 90 11 dog dog NN cord-342150-dadc8whz 90 12 lungs lung NNS cord-342150-dadc8whz 90 13 Effect effect NN cord-342150-dadc8whz 90 14 of of IN cord-342150-dadc8whz 90 15 posture posture NN cord-342150-dadc8whz 90 16 on on IN cord-342150-dadc8whz 90 17 inter inter JJ cord-342150-dadc8whz 90 18 - - JJ cord-342150-dadc8whz 90 19 regional regional JJ cord-342150-dadc8whz 90 20 distribution distribution NN cord-342150-dadc8whz 90 21 of of IN cord-342150-dadc8whz 90 22 pulmonary pulmonary JJ cord-342150-dadc8whz 90 23 ventilation ventilation NN cord-342150-dadc8whz 90 24 in in IN cord-342150-dadc8whz 90 25 man man NN cord-342150-dadc8whz 91 1 The the DT cord-342150-dadc8whz 91 2 prone prone JJ cord-342150-dadc8whz 91 3 position position NN cord-342150-dadc8whz 91 4 in in IN cord-342150-dadc8whz 91 5 ARDS ARDS NNP cord-342150-dadc8whz 91 6 patients patient NNS cord-342150-dadc8whz 91 7 : : : cord-342150-dadc8whz 91 8 a a DT cord-342150-dadc8whz 91 9 clinical clinical JJ cord-342150-dadc8whz 91 10 study study NN cord-342150-dadc8whz 92 1 The the DT cord-342150-dadc8whz 92 2 prone prone JJ cord-342150-dadc8whz 92 3 positioning positioning NN cord-342150-dadc8whz 92 4 during during IN cord-342150-dadc8whz 92 5 general general JJ cord-342150-dadc8whz 92 6 anesthesia anesthesia NN cord-342150-dadc8whz 92 7 minimally minimally RB cord-342150-dadc8whz 92 8 affects affect VBZ cord-342150-dadc8whz 92 9 respiratory respiratory JJ cord-342150-dadc8whz 92 10 mechanics mechanic NNS cord-342150-dadc8whz 92 11 while while IN cord-342150-dadc8whz 92 12 improving improve VBG cord-342150-dadc8whz 92 13 functional functional JJ cord-342150-dadc8whz 92 14 residual residual JJ cord-342150-dadc8whz 92 15 capacity capacity NN cord-342150-dadc8whz 92 16 and and CC cord-342150-dadc8whz 92 17 increasing increase VBG cord-342150-dadc8whz 92 18 oxygen oxygen NN cord-342150-dadc8whz 92 19 tension tension NN cord-342150-dadc8whz 93 1 Prone prone JJ cord-342150-dadc8whz 93 2 positioning positioning NN cord-342150-dadc8whz 93 3 improves improve VBZ cord-342150-dadc8whz 93 4 pulmonary pulmonary JJ cord-342150-dadc8whz 93 5 function function NN cord-342150-dadc8whz 93 6 in in IN cord-342150-dadc8whz 93 7 obese obese JJ cord-342150-dadc8whz 93 8 patients patient NNS cord-342150-dadc8whz 93 9 during during IN cord-342150-dadc8whz 93 10 general general JJ cord-342150-dadc8whz 93 11 anesthesia anesthesia NN cord-342150-dadc8whz 93 12 Dramatic dramatic JJ cord-342150-dadc8whz 93 13 effect effect NN cord-342150-dadc8whz 93 14 on on IN cord-342150-dadc8whz 93 15 oxygenation oxygenation NN cord-342150-dadc8whz 93 16 in in IN cord-342150-dadc8whz 93 17 patients patient NNS cord-342150-dadc8whz 93 18 with with IN cord-342150-dadc8whz 93 19 severe severe JJ cord-342150-dadc8whz 93 20 acute acute JJ cord-342150-dadc8whz 93 21 lung lung NN cord-342150-dadc8whz 93 22 insufficiency insufficiency NN cord-342150-dadc8whz 93 23 treated treat VBN cord-342150-dadc8whz 93 24 in in IN cord-342150-dadc8whz 93 25 the the DT cord-342150-dadc8whz 93 26 prone prone JJ cord-342150-dadc8whz 93 27 position position NN cord-342150-dadc8whz 93 28 Pulmonary pulmonary JJ cord-342150-dadc8whz 93 29 gas gas NN cord-342150-dadc8whz 93 30 exchange exchange NN cord-342150-dadc8whz 93 31 improves improve VBZ cord-342150-dadc8whz 93 32 in in IN cord-342150-dadc8whz 93 33 the the DT cord-342150-dadc8whz 93 34 prone prone JJ cord-342150-dadc8whz 93 35 position position NN cord-342150-dadc8whz 93 36 with with IN cord-342150-dadc8whz 93 37 abdominal abdominal JJ cord-342150-dadc8whz 93 38 distension distension NN cord-342150-dadc8whz 93 39 Pulmonary pulmonary JJ cord-342150-dadc8whz 93 40 perfusion perfusion NN cord-342150-dadc8whz 93 41 is be VBZ cord-342150-dadc8whz 93 42 more more RBR cord-342150-dadc8whz 93 43 uniform uniform NN cord-342150-dadc8whz 93 44 in in IN cord-342150-dadc8whz 93 45 the the DT cord-342150-dadc8whz 93 46 prone prone JJ cord-342150-dadc8whz 93 47 than than IN cord-342150-dadc8whz 93 48 in in IN cord-342150-dadc8whz 93 49 the the DT cord-342150-dadc8whz 93 50 supine supine JJ cord-342150-dadc8whz 93 51 position position NN cord-342150-dadc8whz 93 52 : : : cord-342150-dadc8whz 93 53 scintigraphy scintigraphy NN cord-342150-dadc8whz 93 54 in in IN cord-342150-dadc8whz 93 55 healthy healthy JJ cord-342150-dadc8whz 93 56 humans human NNS cord-342150-dadc8whz 93 57 Paradoxical paradoxical JJ cord-342150-dadc8whz 93 58 redistribution redistribution NN cord-342150-dadc8whz 93 59 of of IN cord-342150-dadc8whz 93 60 pulmonary pulmonary JJ cord-342150-dadc8whz 93 61 blood blood NN cord-342150-dadc8whz 93 62 flow flow NN cord-342150-dadc8whz 93 63 in in IN cord-342150-dadc8whz 93 64 prone prone JJ cord-342150-dadc8whz 93 65 and and CC cord-342150-dadc8whz 93 66 supine supine JJ cord-342150-dadc8whz 93 67 humans human NNS cord-342150-dadc8whz 93 68 exposed expose VBN cord-342150-dadc8whz 93 69 to to IN cord-342150-dadc8whz 93 70 hypergravity hypergravity NNP cord-342150-dadc8whz 93 71 Fractal Fractal NNP cord-342150-dadc8whz 93 72 properties property NNS cord-342150-dadc8whz 93 73 of of IN cord-342150-dadc8whz 93 74 pulmonary pulmonary JJ cord-342150-dadc8whz 93 75 blood blood NN cord-342150-dadc8whz 93 76 flow flow NN cord-342150-dadc8whz 93 77 : : : cord-342150-dadc8whz 93 78 characterization characterization NN cord-342150-dadc8whz 93 79 of of IN cord-342150-dadc8whz 93 80 spatial spatial JJ cord-342150-dadc8whz 93 81 heterogeneity heterogeneity NN cord-342150-dadc8whz 93 82 High high JJ cord-342150-dadc8whz 93 83 - - HYPH cord-342150-dadc8whz 93 84 resolution resolution NN cord-342150-dadc8whz 93 85 maps map NNS cord-342150-dadc8whz 93 86 of of IN cord-342150-dadc8whz 93 87 regional regional JJ cord-342150-dadc8whz 93 88 ventilation ventilation NN cord-342150-dadc8whz 93 89 utilizing utilize VBG cord-342150-dadc8whz 93 90 inhaled inhale VBN cord-342150-dadc8whz 93 91 fluorescent fluorescent NN cord-342150-dadc8whz 93 92 microspheres microsphere NNS cord-342150-dadc8whz 93 93 Pulmonary pulmonary JJ cord-342150-dadc8whz 93 94 blood blood NN cord-342150-dadc8whz 93 95 flow flow NN cord-342150-dadc8whz 93 96 distribution distribution NN cord-342150-dadc8whz 93 97 has have VBZ cord-342150-dadc8whz 93 98 a a DT cord-342150-dadc8whz 93 99 hilar hilar JJ cord-342150-dadc8whz 93 100 - - HYPH cord-342150-dadc8whz 93 101 to to IN cord-342150-dadc8whz 93 102 - - HYPH cord-342150-dadc8whz 93 103 peripheral peripheral JJ cord-342150-dadc8whz 93 104 gradient gradient NN cord-342150-dadc8whz 93 105 in in IN cord-342150-dadc8whz 93 106 awake awake JJ cord-342150-dadc8whz 93 107 , , , cord-342150-dadc8whz 93 108 prone prone JJ cord-342150-dadc8whz 93 109 sheep sheep NN cord-342150-dadc8whz 93 110 Pulmonary pulmonary JJ cord-342150-dadc8whz 93 111 gas gas NN cord-342150-dadc8whz 93 112 - - HYPH cord-342150-dadc8whz 93 113 exchange exchange NN cord-342150-dadc8whz 93 114 analysis analysis NN cord-342150-dadc8whz 93 115 by by IN cord-342150-dadc8whz 93 116 using use VBG cord-342150-dadc8whz 93 117 simultaneous simultaneous JJ cord-342150-dadc8whz 93 118 deposition deposition NN cord-342150-dadc8whz 93 119 of of IN cord-342150-dadc8whz 93 120 aerosolized aerosolize VBN cord-342150-dadc8whz 93 121 and and CC cord-342150-dadc8whz 93 122 injected inject VBN cord-342150-dadc8whz 93 123 microspheres microsphere NNS cord-342150-dadc8whz 94 1 Gravity gravity NN cord-342150-dadc8whz 94 2 is be VBZ cord-342150-dadc8whz 94 3 a a DT cord-342150-dadc8whz 94 4 minor minor JJ cord-342150-dadc8whz 94 5 determinant determinant NN cord-342150-dadc8whz 94 6 of of IN cord-342150-dadc8whz 94 7 pulmonary pulmonary JJ cord-342150-dadc8whz 94 8 blood blood NN cord-342150-dadc8whz 94 9 flow flow NN cord-342150-dadc8whz 94 10 distribution distribution NN cord-342150-dadc8whz 94 11 Gravity gravity NN cord-342150-dadc8whz 94 12 is be VBZ cord-342150-dadc8whz 94 13 an an DT cord-342150-dadc8whz 94 14 important important JJ cord-342150-dadc8whz 94 15 but but CC cord-342150-dadc8whz 94 16 secondary secondary JJ cord-342150-dadc8whz 94 17 determinant determinant NN cord-342150-dadc8whz 94 18 of of IN cord-342150-dadc8whz 94 19 regional regional JJ cord-342150-dadc8whz 94 20 pulmonary pulmonary JJ cord-342150-dadc8whz 94 21 blood blood NN cord-342150-dadc8whz 94 22 flow flow NN cord-342150-dadc8whz 94 23 in in IN cord-342150-dadc8whz 94 24 upright upright JJ cord-342150-dadc8whz 94 25 primates primate NNS cord-342150-dadc8whz 95 1 Pulmonary pulmonary JJ cord-342150-dadc8whz 95 2 blood blood NN cord-342150-dadc8whz 95 3 flow flow NN cord-342150-dadc8whz 95 4 remains remain VBZ cord-342150-dadc8whz 95 5 fractal fractal JJ cord-342150-dadc8whz 95 6 down down RB cord-342150-dadc8whz 95 7 to to IN cord-342150-dadc8whz 95 8 the the DT cord-342150-dadc8whz 95 9 level level NN cord-342150-dadc8whz 95 10 of of IN cord-342150-dadc8whz 95 11 gas gas NN cord-342150-dadc8whz 95 12 exchange exchange NN cord-342150-dadc8whz 95 13 Regional regional JJ cord-342150-dadc8whz 95 14 ventilation ventilation NN cord-342150-dadc8whz 95 15 - - HYPH cord-342150-dadc8whz 95 16 perfusion perfusion NN cord-342150-dadc8whz 95 17 distribution distribution NN cord-342150-dadc8whz 95 18 is be VBZ cord-342150-dadc8whz 95 19 more more RBR cord-342150-dadc8whz 95 20 uniform uniform JJ cord-342150-dadc8whz 95 21 in in IN cord-342150-dadc8whz 95 22 the the DT cord-342150-dadc8whz 95 23 prone prone JJ cord-342150-dadc8whz 95 24 position position NN cord-342150-dadc8whz 95 25 Posture Posture NNP cord-342150-dadc8whz 95 26 primarily primarily RB cord-342150-dadc8whz 95 27 affects affect VBZ cord-342150-dadc8whz 95 28 the the DT cord-342150-dadc8whz 95 29 distribution distribution NN cord-342150-dadc8whz 95 30 of of IN cord-342150-dadc8whz 95 31 lung lung NN cord-342150-dadc8whz 95 32 tissue tissue NN cord-342150-dadc8whz 95 33 with with IN cord-342150-dadc8whz 95 34 minor minor JJ cord-342150-dadc8whz 95 35 effect effect NN cord-342150-dadc8whz 95 36 on on IN cord-342150-dadc8whz 95 37 regional regional JJ cord-342150-dadc8whz 95 38 blood blood NN cord-342150-dadc8whz 95 39 flow flow NN cord-342150-dadc8whz 95 40 and and CC cord-342150-dadc8whz 95 41 ventilation ventilation NN cord-342150-dadc8whz 95 42 Lung lung NN cord-342150-dadc8whz 95 43 ventilation ventilation NN cord-342150-dadc8whz 95 44 and and CC cord-342150-dadc8whz 95 45 perfusion perfusion NN cord-342150-dadc8whz 95 46 in in IN cord-342150-dadc8whz 95 47 prone prone JJ cord-342150-dadc8whz 95 48 and and CC cord-342150-dadc8whz 95 49 supine supine JJ cord-342150-dadc8whz 95 50 postures posture NNS cord-342150-dadc8whz 95 51 with with IN cord-342150-dadc8whz 95 52 reference reference NN cord-342150-dadc8whz 95 53 to to IN cord-342150-dadc8whz 95 54 anesthetized anesthetized JJ cord-342150-dadc8whz 95 55 and and CC cord-342150-dadc8whz 95 56 mechanically mechanically RB cord-342150-dadc8whz 95 57 ventilated ventilate VBN cord-342150-dadc8whz 95 58 healthy healthy JJ cord-342150-dadc8whz 95 59 volunteers volunteer NNS cord-342150-dadc8whz 95 60 Pulmonary pulmonary JJ cord-342150-dadc8whz 95 61 blood blood NN cord-342150-dadc8whz 95 62 flow flow NN cord-342150-dadc8whz 95 63 distribution distribution NN cord-342150-dadc8whz 95 64 in in IN cord-342150-dadc8whz 95 65 standing stand VBG cord-342150-dadc8whz 95 66 horses horse NNS cord-342150-dadc8whz 95 67 is be VBZ cord-342150-dadc8whz 95 68 not not RB cord-342150-dadc8whz 95 69 dominated dominate VBN cord-342150-dadc8whz 95 70 by by IN cord-342150-dadc8whz 95 71 gravity gravity NN cord-342150-dadc8whz 95 72 Regional regional JJ cord-342150-dadc8whz 95 73 differences difference NNS cord-342150-dadc8whz 95 74 in in IN cord-342150-dadc8whz 95 75 endothelial endothelial JJ cord-342150-dadc8whz 95 76 function function NN cord-342150-dadc8whz 95 77 in in IN cord-342150-dadc8whz 95 78 horse horse NN cord-342150-dadc8whz 95 79 lungs lung NNS cord-342150-dadc8whz 95 80 : : : cord-342150-dadc8whz 96 1 possible possible JJ cord-342150-dadc8whz 96 2 role role NN cord-342150-dadc8whz 96 3 in in IN cord-342150-dadc8whz 96 4 blood blood NN cord-342150-dadc8whz 96 5 flow flow NN cord-342150-dadc8whz 96 6 distribution distribution NN cord-342150-dadc8whz 96 7 ? ? . cord-342150-dadc8whz 97 1 Regulation regulation NN cord-342150-dadc8whz 97 2 of of IN cord-342150-dadc8whz 97 3 regional regional JJ cord-342150-dadc8whz 97 4 lung lung NN cord-342150-dadc8whz 97 5 perfusion perfusion NN cord-342150-dadc8whz 97 6 by by IN cord-342150-dadc8whz 97 7 nitric nitric NN cord-342150-dadc8whz 97 8 oxide oxide NN cord-342150-dadc8whz 97 9 Using use VBG cord-342150-dadc8whz 97 10 the the DT cord-342150-dadc8whz 97 11 prone prone JJ cord-342150-dadc8whz 97 12 position position NN cord-342150-dadc8whz 97 13 could could MD cord-342150-dadc8whz 97 14 help help VB cord-342150-dadc8whz 97 15 to to TO cord-342150-dadc8whz 97 16 combat combat VB cord-342150-dadc8whz 97 17 the the DT cord-342150-dadc8whz 97 18 development development NN cord-342150-dadc8whz 97 19 of of IN cord-342150-dadc8whz 97 20 fast fast JJ cord-342150-dadc8whz 97 21 hypoxia hypoxia NN cord-342150-dadc8whz 97 22 in in IN cord-342150-dadc8whz 97 23 some some DT cord-342150-dadc8whz 97 24 patients patient NNS cord-342150-dadc8whz 97 25 with with IN cord-342150-dadc8whz 97 26 COVID-19 COVID-19 NNP